WorldWideScience

Sample records for cantilever-actuated peristaltic micropump

  1. Development of a high performance peristaltic micropump

    Science.gov (United States)

    Pham, My; Goo, Nam Seo

    2008-03-01

    In this study, a high performance peristaltic micropump has been developed and investigated. The micropump has three cylinder chambers which are connected through micro-channels for high pumping pressure performance. A circular-shaped mini LIPCA has been designed and manufactured for actuating diaphragm. In this LIPCA, a 0.1mm thickness PZT ceramic is used as an active layer. As a result, the actuator has shown to produce large out of plane deflection and consumed low power. During the design process, a coupled field analysis was conducted to predict the actuating behavior of a diaphragm and pumping performance. MEMS technique was used to fabricate the peristaltic micropump. Pumping performance of the present micropump was investigated both numerically and experimentally. The present peristaltic micropump was shown to have higher performance than the same kind of micropump developed else where.

  2. Development and characterization of thermopneumatic peristaltic micropumps

    International Nuclear Information System (INIS)

    In this paper, the development and characterization of thermopneumatic peristaltic micropumps are presented. Micropumps with three different designs are fabricated using soft lithography techniques. The equivalent circuit models of a thermopneumatic actuation cell are formulated. The analytical solutions for predicting the device transient behavior are also derived. The dynamical responses of the diaphragms are measured using an interferometer, and are in good agreement with the modeled results. Tiny drive circuits, which require only 5 V, are implemented for driving the pumps. The dimension of an integrated 3-chamber micropump system, which consists of a pump and a drive circuit, is 16 mm × 18 mm × 5.5 mm. The optimal operating conditions, such as actuation sequences, operating frequencies and duty ratios, are obtained. The maximum flow rate occurs at a driving frequency of 1.5 Hz with a duty ratio of 40% using a three-phase actuation sequence. A simplified pseudo thermo-fluid-structure-interaction (pT-FSI) model is also proposed to estimate the pumping characteristic. The model gives reasonable results under low operation frequency. Under zero backpressure, the maximum flow rates for the 3, 5 and 7-chamber devices are very close, whereas the devices with larger numbers of pumping chambers exhibit better pumping performance under higher backpressure

  3. Development and characterization of thermopneumatic peristaltic micropumps

    Science.gov (United States)

    Yang, Yao-Joe; Liao, Hsin-Hung

    2009-02-01

    In this paper, the development and characterization of thermopneumatic peristaltic micropumps are presented. Micropumps with three different designs are fabricated using soft lithography techniques. The equivalent circuit models of a thermopneumatic actuation cell are formulated. The analytical solutions for predicting the device transient behavior are also derived. The dynamical responses of the diaphragms are measured using an interferometer, and are in good agreement with the modeled results. Tiny drive circuits, which require only 5 V, are implemented for driving the pumps. The dimension of an integrated 3-chamber micropump system, which consists of a pump and a drive circuit, is 16 mm × 18 mm × 5.5 mm. The optimal operating conditions, such as actuation sequences, operating frequencies and duty ratios, are obtained. The maximum flow rate occurs at a driving frequency of 1.5 Hz with a duty ratio of 40% using a three-phase actuation sequence. A simplified pseudo thermo-fluid-structure-interaction (pT-FSI) model is also proposed to estimate the pumping characteristic. The model gives reasonable results under low operation frequency. Under zero backpressure, the maximum flow rates for the 3, 5 and 7-chamber devices are very close, whereas the devices with larger numbers of pumping chambers exhibit better pumping performance under higher backpressure.

  4. A vacuum-driven peristaltic micropump with valved actuation chambers

    International Nuclear Information System (INIS)

    This paper presents a simple peristaltic micropump design incorporated with valved actuation chambers and propelled by a pulsed vacuum source. The vacuum-driven peristaltic micropump offers high pumping rates, low backflow, appreciable tolerance to air bubbles, and minimal destruction to fluid contents. The pumping device, fabricated by laser micromachining and plasma bonding of three polydimethylsiloxane (PDMS) layers, includes a pneumatic network, actuation membranes, and microfluidic channels. As the key to peristaltic motion, the sequential deflection of the elastic membranes is achieved by periodic pressure waveforms (negative) traveling through the pneumatic network, provided by a vacuum source regulated by an electromagnetic valve. This configuration eliminates the complicated control logic typically required in peristaltic motion. Importantly, the valved actuation chambers substantially reduce backflow and improve the pumping rates. In addition, the pneumatic network with negative pressure provides a means to effectively remove air bubbles present in the microflow through the gas-permeable PDMS membrane, which can be highly desired in handling complex fluidic samples. Experimental characterization of the micropump performance has been conducted by controlling the resistance of the pneumatic network, the number of normally closed valves, the vacuum pressure, and the frequency of pressure pulses. A maximal flow rate of 600 µL min−1 has been optimized at the pulsed vacuum frequency of 30 Hz with a vacuum pressure of 50 kPa, which is comparable to that of compressed air-actuated peristaltic micropumps

  5. A peristaltic micropump using traveling waves on a polymer membrane

    International Nuclear Information System (INIS)

    We demonstrate a peristaltic micropump that utilizes traveling waves on polymer membranes to transport liquids. This micropump requires no valves and, more importantly, the traveling waves can be generated by a single actuator. These features enable the design of simple, compact devices. This micropump has a hydraulic displacement amplification mechanism (HDAM) that encapsulates an incompressible fluid with flexible polymer membranes made of polydimethyl siloxane. A microchannel is attached to the top side of the HDAM. We used a cantilever-type piezoelectric actuator to oscillate the flexible membrane at the bottom of the HDAM, while the top-side membrane drives the liquid in the channel. This format enables rectangular parallelepiped micropumps as compact as 36 mm long, 10 mm wide and several millimeters high, depending on the channel height. Experiments using the fabricated micropumps equipped with microchannels of various heights revealed that the flow rate was dependent on the ratio of the amplitude of the traveling waves to the height of the fluidic channel. The manufactured micropump could successfully generate a maximum flow rate of 1.5 ml min−1 at 180 mW. (paper)

  6. PDMS Based Thermopnuematic Peristaltic Micropump for Microfluidic Systems

    International Nuclear Information System (INIS)

    A thermopnuematic peristaltic micropump for controlling micro litters of fluid was designed and fabricated from multi-stack PDMS structure on glass substrate. Pump structure consists of inlet and outlet, microchannel, three thermopneumatic actuation chambers, and three heaters. In microchannel, fluid is controlled and pumped by peristaltic motion of actuation diaphragm. Actuation diaphragm can bend up and down by exploiting air expansion that is induced by increasing heater temperature. The micropump characteristics were measured as a function of applied voltage and frequency. The flow rate was determined by periodically recording the motion of fluid at Nanoport output and computing flow volume from height difference between consecutive records. From the experiment, an optimum flow rate of 0.82 μl/min is obtained under 14 V three-phase input voltages at 0.033 Hz operating frequency

  7. Portable Valve-less Peristaltic Micro-pump Design and Fabrication

    CERN Document Server

    Yang, H; Hu, C -C

    2008-01-01

    This paper is to describe a design and fabrication method for a valve-less peristaltic micro-pump. The valve-less peristaltic micro-pump with three membrane chambers in a serial is actuated by three piezoelectric (PZT) actuators. With the fluidic flow design, liquid in the flow channel is pumped to a constant flow speed ranged from 0.4 to 0.48 mm/s. In term of the maximum flow rate of the micro-pump is about 365 mircoliters/min, when the applied voltage is 24V and frequency 50 Hz. Photolithography process was used to fabricate the micro-pump mold. PDMS molding and PDMS bonding method were used to fabricate the micro-channel and actuator chambers. A portable drive controller was designed to control three PZT actuators in a proper sequence to drive the chamber membrane. Then, all parts were integrated into the portable valve-less peristaltic micro-pump system.

  8. Portable Valve-less Peristaltic Micro-pump Design and Fabrication

    OpenAIRE

    Yang, H.; Tsai, T.-H.; Hu, C.-C.

    2008-01-01

    This paper is to describe a design and fabrication method for a valve-less peristaltic micro-pump. The valve-less peristaltic micro-pump with three membrane chambers in a serial is actuated by three piezoelectric (PZT) actuators. With the fluidic flow design, liquid in the flow channel is pumped to a constant flow speed ranged from 0.4 to 0.48 mm/s. In term of the maximum flow rate of the micro-pump is about 365 mircoliters/min, when the applied voltage is 24V and frequency 50 Hz. Photolithog...

  9. Experimental analysis of time-phase-shift flow sensing based on a piezoelectric peristaltic micropump

    Science.gov (United States)

    Huang, Pao-Cheng; Wang, Min-Haw; Chen, Ming-Kun; Jang, Ling-Sheng

    2016-05-01

    Flow rate sensing is a critical issue for piezoelectric-based micropump systems. This paper describes experimental analysis of flow rate sensing in a peristaltic micropump system. Sensing can be integrated with such a pump using piezoelectric actuators based on the time-phase-shift (TPS) method. To do this, an evaluation-window is added on the falling edge of the driving pulse to help detect the flow velocity without affecting the flow rate. We fabricate a prototype piezoelectric peristaltic micropump with three chambers and three piezoelectric actuators. The middle actuator works not only as an actuator for driving fluid but also as a transducer for sensing flow rate. An evaluation-window is performed to ascertain the relationship between the flow rate and the phase shift of output-signal responses from the transducer. The experimental results show that the evaluation-window response of flow rates in a piezoelectric peristaltic micropump has rates of from 5.56‒33.36 μl s-1. The results are extended to propose a practical flow rate sensor, the design of which can be realized easily in the piezoelectric peristaltic micropump system for sensorless responses that can detect flow rate without any sensors or circuits. The proposed TPS method is real-time, integrated, fast, efficient, and suitable for flow rate detection in piezoelectric peristaltic micropumps.

  10. Development of a peristaltic gas micropump with a single chamber and multiple electrodes

    International Nuclear Information System (INIS)

    This paper reports on the development of a multi-electrode electrostatically driven peristaltic gas micropump. The micropump consists of a single chamber and a flexible diaphragm with a multi-electrode pattern. The single-chamber design is divided into smaller cells by the electrodes; the characteristic operating frequency of the micropump increases as the number of electrodes increases. The flow rate is also observed to increase to maximum before decreasing for larger numbers of electrodes. Whereas the maximum flow rate of a 4-electrode micropump is about 40 µl min−1 at 14 Hz, the maximum flow rate of the 16-electrode micropump is about 250 µl min−1 at 1400 Hz and that of the 32-electrode micropump is 150 µl min−1 at 4000 Hz. (paper)

  11. Development of a peristaltic micropump for bio-medical applications based on mini LIPCA

    OpenAIRE

    Pham, My; Nguyen, Thanh Tung; Goo, Nam Seo

    2008-01-01

    This paper presents the design, fabrication, and experimental characterization of a peristaltic micropump. The micropump is composed of two layers fabricated from polydimethylsiloxane (PDMS) material. The first layer has a rectangular channel and two valve seals. Three rectangular mini lightweight piezo-composite actuators are integrated in the second layer, and used as actuation parts. Two layers are bonded, and covered by two polymethyl methacrylate (PMMA) plates, which help increase the st...

  12. Dynamic simulation of a peristaltic micropump considering coupled fluid flow and structural motion

    OpenAIRE

    Lin, Qiao; Yang, Bozhi; Xie, Jun; Tai, Yu-Chong

    2007-01-01

    This paper presents lumped-parameter simulation of dynamic characteristics of peristaltic micropumps. The pump consists of three pumping cells connected in series, each of which is equipped with a compliant diaphragm that is electrostatically actuated in a peristaltic sequence to mobilize the fluid. Diaphragm motion in each pumping cell is first represented by an effective spring subjected to hydrodynamic and electrostatic forces. These cell representations are then used to construct a system...

  13. Development of a peristaltic micropump for bio-medical applications based on mini LIPCA

    CERN Document Server

    Pham, My; Goo, Nam Seo

    2008-01-01

    This paper presents the design, fabrication, and experimental characterization of a peristaltic micropump. The micropump is composed of two layers fabricated from polydimethylsiloxane (PDMS) material. The first layer has a rectangular channel and two valve seals. Three rectangular mini lightweight piezo-composite actuators are integrated in the second layer, and used as actuation parts. Two layers are bonded, and covered by two polymethyl methacrylate (PMMA) plates, which help increase the stiffness of the micropump. A maximum flow rate of 900 mokroliter per min and a maximum backpressure of 1.8 kPa are recorded when water is used as pump liquid. We measured the power consumption of the micropump. The micropump is found to be a promising candidate for bio-medical application due to its bio-compatibility, portability, bidirectionality, and simple effective design.

  14. Development of a Peristaltic Micropump for Bio-Medical Applications Based on Mini LIPCA

    Institute of Scientific and Technical Information of China (English)

    Thanh Tung Nguyen; My Pham; Nam Seo Goo

    2008-01-01

    This paper presents the design, fabrication, and experimental characterization of a peristaltic micropump. The micropump is composed of two layers fabricated from Polydimethylsiloxane (PDMS) material. The first layer has a rectangular channel and two valve seals. Three rectangular mini lightweight piezo-composite actuators are integrated in the second layer, and used as actuation parts.Two layers are bonded, and covered by two Polymethyl Methacrylate (PMMA) plates, which help increase the stiffness of the micropump.A maximum flow rate of 900 uL·min-1 and a maximum backpressure of 1.8 kPa are recorded when water is used as pump liquid. We measured the power consumption of the micropump. The micropump is found to be a prom- ising candidate for bio-medical application due to its bio-compatibility, portability, bidirectionality, and simple effective design.

  15. Design and dynamic characterization of "single-stroke" peristaltic PDMS micropumps.

    Science.gov (United States)

    Lai, Hoyin; Folch, Albert

    2011-01-21

    In this paper, we present a monolithic PDMS micropump that generates peristaltic flow using a single control channel that actuates a group of different-sized microvalves. An elastomeric microvalve design with a raised seat, which improves bonding reliability, is incorporated into the micropump. Pump performance is evaluated based on several design parameters--size, number, and connection of successive microvalves along with control channel pressure at various operating frequencies. Flow rates ranging 0-5.87 µL min(-1) were observed. The micropump design demonstrated here represents a substantial reduction in the number of/real estate taken up by the control lines that are required to run a peristaltic pump, hence it should become a widespread tool for parallel fluid processing in high-throughput microfluidics. PMID:20957288

  16. Effect of actuation sequence on flow rates of peristaltic micropumps with PZT actuators.

    Science.gov (United States)

    Jang, Ling-Sheng; Shu, Kuan; Yu, Yung-Chiang; Li, Yuan-Jie; Chen, Chiun-Hsun

    2009-02-01

    Many biomedical applications require the administration of drugs at a precise and preferably programmable rate. The flow rate generated by the peristaltic micropumps used in such applications depends on the actuation sequence. Accordingly, the current study performs an analytical and experimental investigation to determine the correlation between the dynamic response of the diaphragms in the micropump and the actuation sequence. A simple analytical model of a peristaltic micropump is established to analyze the shift in the resonant frequency of the diaphragms caused by the viscous damping effect. The analytical results show that this damping effect increases as the oscillation frequency of the diaphragm increases. A peristaltic micropump with three piezoelectric actuators is fabricated on a silicon substrate and is actuated using 2-, 3-, 4- and 6-phase actuation sequences via a driving system comprising a microprocessor and a phase controller. A series of experiments is conducted using de-ionized water as the working fluid to determine the diaphragm displacement and the flow rates induced by each of the different actuation sequences under phase frequencies ranging from 50 Hz to 1 MHz. The results show that the damping effect of actuation sequences influences diaphragm resonant frequency, which in turn affects the profiles of flow rates. PMID:18821016

  17. Dynamic simulation of a peristaltic micropump considering coupled fluid flow and structural motion

    Science.gov (United States)

    Lin, Qiao; Yang, Bozhi; Xie, Jun; Tai, Yu-Chong

    2007-02-01

    This paper presents lumped-parameter simulation of dynamic characteristics of peristaltic micropumps. The pump consists of three pumping cells connected in series, each of which is equipped with a compliant diaphragm that is electrostatically actuated in a peristaltic sequence to mobilize the fluid. Diaphragm motion in each pumping cell is first represented by an effective spring subjected to hydrodynamic and electrostatic forces. These cell representations are then used to construct a system-level model for the entire pump, which accounts for both cell- and pump-level interactions of fluid flow and diaphragm vibration. As the model is based on first principles, it can be evaluated directly from the device's geometry, material properties and operating parameters without using any experimentally identified parameters. Applied to an existing pump, the model correctly predicts trends observed in experiments. The model is then used to perform a systematic analysis of the impact of geometry, materials and pump loading on device performance, demonstrating its utility as an efficient tool for peristaltic micropump design.

  18. Rotary Peristaltic Micro-Pump Based on the Nano-Magnetic Fluid%基于纳米磁性液体的旋转式蠕动微泵

    Institute of Scientific and Technical Information of China (English)

    吴健; 刘同冈; 张亮

    2013-01-01

    A rotary peristaltic micro-pump based on the nano-magnetic fluid was designed,which was composed of an upper substrate,a lower substrate and an elastic film positioned between the two substrates.A micro-channel was machined on each substrate,the magnetic fluid in the upper micro-channel was gathered by a permanent magnet to deform the elastic film in order to push the sample liquid in the lower micro-channel.Both micro-channels were designed with the ring structure to pump the liquid continuously.The operational result indicates that the flow rate and output pressure are the combination result of the positive pressure generated by the gradient magnetic field and the driving force produced by the moving magnetic field.When the rotational speed of the magnetic field is 6 r/min,the maximum output pressure and flow rate of the micro-pump are 1 600 Pa and 1.8 mL/min,respectively.%设计了一种基于纳米磁性液体的旋转式蠕动微泵.泵体由上、下基板和弹性薄膜组成,弹性薄膜位于上、下基板的中间位置.在上、下基板上分别加工出微型管道,上管道中的纳米磁性液体在磁场作用下压迫弹性薄膜变形,从而推动下管道中的液体流动,并且采用环形结构,实现连续泵送的目的.运行结果显示:泵送流量和泵送压力是梯度磁场产生的正压力与移动磁场产生的驱动力共同作用的结果.当磁场旋转速度达到6 r/min时,微泵产生的最大泵送压力达1 600 Pa,此时的流量为1.8 mL/min.

  19. Deformation Analysis of a Pneumatically-Activated Polydimethylsiloxane (PDMS) Membrane and Potential Micro-Pump Applications

    OpenAIRE

    Chi-Han Chiou; Tai-Yen Yeh; Jr-Lung Lin

    2015-01-01

    This study presents a double-side diaphragm peristaltic pump for efficient medium transport without the unwanted backflow and the lagging effect of a diaphragm. A theoretical model was derived to predict the important parameter of the micropump, i.e., the motion of the valves at large deformations, for a variety of air pressures. Accordingly, we proposed an easy and robust design to fabricate a Polydimethylsiloxane (PDMS)-based micropump. The theoretical model agrees with a numerical model an...

  20. Deformation Analysis of a Pneumatically-Activated Polydimethylsiloxane (PDMS Membrane and Potential Micro-Pump Applications

    Directory of Open Access Journals (Sweden)

    Chi-Han Chiou

    2015-01-01

    Full Text Available This study presents a double-side diaphragm peristaltic pump for efficient medium transport without the unwanted backflow and the lagging effect of a diaphragm. A theoretical model was derived to predict the important parameter of the micropump, i.e., the motion of the valves at large deformations, for a variety of air pressures. Accordingly, we proposed an easy and robust design to fabricate a Polydimethylsiloxane (PDMS-based micropump. The theoretical model agrees with a numerical model and experimental data for the deformations of the PDMS membrane. Furthermore, variations of the generated flow rate, including pneumatic frequencies, actuated air pressures, and operation modes were evaluated experimentally for the proposed micropumps. In future, the theoretical equation could provide the optimal parameters for the scientists working on the fabrication of the diaphragm peristaltic pump for applications of cell-culture.

  1. All Polymer Micropump

    OpenAIRE

    Hansen, Thomas Steen; Larsen, Niels Bent; Hassager, Ole

    2008-01-01

    In this thesis an all polymer micropump, and the fabrication method required to fabricate this, are examined. Polymer microfluidic. devices are of major scientific interest because they can combine complicated chemical and biological analys~s in cheap and disposable devices. The electrode system in the micropump is based on the conducting polymer poly(3,4 ethylenedioxythiophene) (PEDOT). The majority of the work conducted was therefore aimed at developing methods for patterning and processing...

  2. Magnetically actuated micropumps

    OpenAIRE

    Yamahata, Christophe

    2005-01-01

    "Lab-On-a-Chip" (LOC) systems are intended to transpose complete laboratory instrumentations on the few square centimetres of a single microfluidic chip. With such devices the objective is to minimize the time and cost associated with routine biological analysis while improving reproducibility. At the heart of these systems, a fluid delivery unit controls and transfers tiny quantities of liquids enabling the biological assays. This explains the need for robust integrated micropumps as a preco...

  3. Magnetically actuated micropumps

    OpenAIRE

    Yamahata, Christophe; Gijs, Martin

    2007-01-01

    "Lab-On-a-Chip" (LOC) systems are intended to transpose complete laboratory instrumentations on the few square centimetres of a single microfluidic chip. With such devices the objective is to minimize the time and cost associated with routine biological analysis while improving reproducibility. At the heart of these systems, a fluid delivery unit controls and transfers tiny quantities of liquids enabling the biological assays. This explains the need for robust integrated micropumps as a preco...

  4. Design of an implantable micropump

    OpenAIRE

    Smal, Olivier; Merken, Patrick; Croquet, Vincent; Raucent, Benoît; Debongnie, Jean-François; Delchambre, Alain

    2004-01-01

    The implantable programmable micropump is an interesting solution to treat chronic diseases such as diabetes with regular micro-injections of medicine. However, current applications of micropumps are limited by their rather expensive cost. The challenge is therefore to develop a low cost alternative by reducing the number of parts and by simplifying the assembly. As the pump and its tank will be placed under the skin in order to increase comfort, such a system should be small and reliable. In...

  5. All Polymer Micropump

    DEFF Research Database (Denmark)

    Hansen, Thomas Steen

    2008-01-01

    In this thesis an all polymer micropump, and the fabrication method required to fabricate this, are examined. Polymer microfluidic. devices are of major scientific interest because they can combine complicated chemical and biological analys~s in cheap and disposable devices. The electrode system...... room techniques. The conductive blend was coated with a layer of photoresist, exposed and developed. The resulting pattern was etched in a reactive ion etcher, yielding a well defined patterned with a resolution of approximately 2 J..lm. This technique was utilised to fabricate an ac electroosmotic...... a new short chained polyurethane. The resolution of the inkjet printer was in the order of 200 J-tm. The inkjet printed pattern is compared with the agarose stamping technique in a setup where the conductivity perpendicular to the stretching direction is measured on two electrodes fabricated by the two...

  6. Peristaltic ion source

    International Nuclear Information System (INIS)

    Conventional ion sources generate energetic ion beams by accelerating the plasma-produced ions through a voltage drop at the extractor, and since it is usual that the ion beam is to propagate in a space which is at ground potential, the plasma source is biased at extractor voltage. For high ion beam energy the plasma source and electrical systems need to be raised to high voltage, a task that adds considerable complexity and expense to the total ion source system. The authors have developed a system which though forming energetic ion beams at ground potential as usual, operates with the plasma source and electronics at ground potential also. Plasma produced by a nearby source streams into a grided chamber that is repetitively pulsed from ground to high positive potential, sequentially accepting plasma into its interior region and ejecting it energetically. They call the device a peristaltic ion source. In preliminary tests they've produced nitrogen and titanium ion beams at energies from 1 to 40 keV. Here they describe the philosophy behind the approach, the test embodiment that they have made, and some preliminary results

  7. Towards an Implantable, Low Flow Micropump That Uses No Power in the Blocked-Flow State

    Directory of Open Access Journals (Sweden)

    Dean G. Johnson

    2016-06-01

    Full Text Available Low flow rate micropumps play an increasingly important role in drug therapy research. Infusions to small biological structures and lab-on-a-chip applications require ultra-low flow rates and will benefit from the ability to expend no power in the blocked-flow state. Here we present a planar micropump based on gallium phase-change actuation that leverages expansion during solidification to occlude the flow channel in the off-power state. The presented four chamber peristaltic micropump was fabricated with a combination of Micro Electro Mechanical System (MEMS techniques and additive manufacturing direct write technologies. The device is 7 mm × 13 mm × 1 mm (<100 mm3 with the flow channel and exterior coated with biocompatible Parylene-C, critical for implantable applications. Controllable pump rates from 18 to 104 nL/min were demonstrated, with 11.1 ± 0.35 nL pumped per actuation at an efficiency of 11 mJ/nL. The normally-closed state of the gallium actuator prevents flow and diffusion between the pump and the biological system or lab-on-a-chip, without consuming power. This is especially important for implanted applications with periodic drug delivery regimens.

  8. A Magnetic Micropump Based on Ferrofluidic Actuation

    Directory of Open Access Journals (Sweden)

    Lung-Ming Fu

    2014-05-01

    Full Text Available A circular ferrofluidic micropump for biomedical applications is proposed comprising two ferrofluidic plugs contained within a PMMA (Polymethyl-Methacrylate microchannel and driven by a rotating stepping motor. Orthogonal and tangent-type micropumps are developed. The circular ferrofluidic micropump chip is patterned using a commercially-available CO2 laser scriber. The operation of the micropump relies on the use of magnetically-actuated ferrofluidic plugs. The ferrofluid contacts the pumped fluid but is immiscible with it. The flow rate in the two types of proposed devices can be easily controlled by adjusting the rotational velocity of the stepping motor. Results show that a maximum flow rate of 128 μl/min is obtained using the tangent-type micropump with a channel width of 1000 μm and a rotational velocity of 10 rpm with zero pressure head.

  9. Multi-path peristaltic pump

    Science.gov (United States)

    Chandler, Joseph A. (Inventor)

    1986-01-01

    The instant invention is directed to a peristaltic pump for critical laboratory or hospital applications requiring precise flow rates over an extended period of time. Within the cylindrical barrel pump housing is a single-piece, molded, elastometric, cylindrical liner with a multiplicity of flattened helical channels created therein from one end of the liner to the other. Three cylindrical rollers rotate about the center axis of the pump around the inside surface of the liner selectively compressing the liner, and hence the helical channels between the rollers and the barrel housing, creating a pumping action by forcing trapped fluid in the helical channels axially from one end of the liner to the opposite end. The novelty of the invention appears to lie in the provision of the special liner with multiple helical channels as the pumping chamber, rather than the standard single elastomeric tubing which is squeezed repeatedly by rollers to move the liquid through a typical peristaltic pump. Large, repeated deflections on the standard tubing causes a permanent set in the tubing, thus either changing the flow rate, or requiring a new section of tubing to be positioned in the pump head. Further, this configuration minimizes the amount of outflow pulsation which is characteristic of a typical single tubing peristaltic pump.

  10. Induction electrohydrodynamics micropump forhigh heat flux cooling

    OpenAIRE

    Singhal, Vishal; Garimella, S V

    2007-01-01

    Induction electrohydrodynamics (EHD) has been investigated as a possible means of pumping liquids through microchannel heat sinks for cooling microprocessors. A pump utilizing induction EHD has been microfabricated and tested. The experimental results matched the predictions from correlations to within 30%. Based on this, a micropump has been designed which is miniaturizable to a level where it can be integrated into the microchannels. The micropump utilizes a vibrating diaphragm along with i...

  11. A Micropump Driven by Marangoni Effect

    Science.gov (United States)

    Sugimoto, Kenji; Iwamoto, Kaoru; Kawamura, Hiroshi

    A micropump driven by the thermocapillary convection is proposed. The purpose of this study is to examine the flow structure in liquid region and the effect of the geometry on the performance of the present micropump. There are two significant advantages in the thermocapillary-driven system. First, the surface forces become more dominant than the volume forces with decreasing scale. The present micropump driven by the surface forces shows an advantage in the micro scale over a diaphragm pump driven by the volume forces. Secondary, the thermocapillary driven system contains no movable parts; thus, it allows a very simple structure compared to the diaphragm one. In the present micropump system, a number of ribs are distributed along the flow circuit between a heater and a cooler. Since heat transfer from these ribs to the working liquid imposes temperature gradients along the gas-liquid interfaces, the flow from the hot to the cold side is induced by the Marangoni effect. Fundamental characteristics of the present micropump are studied on the basis of three-dimensional simulation conducted taking the gas, liquid and ribs into account. In this study, the flow structure corresponding to the temperature field was observed. The present calculation has revealed that the flow field exhibits a transition from steady flow to oscillatory flow when the Marangoni number exceeds a critical value of about 2,000-2,500. An experiment was also performed. The liquid flow driven by the present micropump system was confirmed through the experiment.

  12. Valveless micropump driven by acoustic streaming

    International Nuclear Information System (INIS)

    This paper describes two valveless micropumps built on a 260 µm thick PZT with 20 µm thick parylene acoustic Fresnel lenses with air cavities. The micropumps produce in-plane body force through acoustic streaming effect of high-intensity acoustic beam that is generated by acoustic wave interference. The fabricated micropumps were shown to move microspheres, which have a diameter of 70–90 µm and a density of 0.99 g cm−3, on the water surface to form U-shape streams of microspheres with a drift velocity of 7.3 cm s−1 when the micropumps were located 4 mm below the water surface and driven by 160 Vpeak-to-peak pulsed sinusoidal waves. The driven microspheres formed U-shape streaming even without any fluidic channel according to the serial connection of the pie-shaped lenses and top electrodes. A micropump with a straight-lined fluidic channel was also fabricated and tested to show a 9.2 cm s−1 microspheres' drift velocity and a 9.5 mL min−1 volume pumping rate when combined with the acrylic acoustic wave reflector. Both the Fresnel lens and top electrode were patterned in a pie-shape with its apex angle of 90° to form asymmetric acoustic pressure distribution at the focal plane of the acoustic Fresnel lenses in order to push water in one direction. (paper)

  13. Design,fabrication and experimental research for an electrohydrodynamic micropump

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    This paper presented a novel electrohydrodynamic (EHD) micropump based on MEMS technology. The working mechanisms and classification of EHD micropump were introduced. The fabrication process of EHD micropump was presented with the material selection,optimal design of microelectrode and assembly process. Static pressure experiments and flow experiments were carried out using different fluid and the channel depth. The results indicated that the micropump could achieve a maximum static pressure head of 268 Pa at an applied voltage of 90 V. The maximum flow rate of the micropump-driven fluid could reach 106 μL/min. This paper analyzed the future of combining micropump with heat pipe to deal with heat dissipation of high power electronic chips. The maximum heat dissipation capacity of 87 W/cm2 can be realized by vaporizing the micropump-driven liquid on vaporizing section of the heat pipe.

  14. Carbon Nanotube Amperometric Chips with Pneumatic Micropumps

    Science.gov (United States)

    Tsujita, Yuichi; Maehashi, Kenzo; Matsumoto, Kazuhiko; Chikae, Miyuki; Torai, Soichiro; Takamura, Yuzuru; Tamiya, Eiichi

    2008-04-01

    We fabricated carbon nanotube (CNT) amperometric chips with pneumatic micropumps by the combination of amperometric biosensors based on CNT-arrayed electrodes and microchannels with pneumatic micropumps made of poly(dimethylsiloxane). On the chip, phosphate buffer solution and potassium ferricyanide, K3[Fe(CN)6], were introduced into the CNT electrodes using each pneumatic micropump and electrochemically measured by differential pulse voltammetry. The results indicate that our chip can automatically exchange reagents on the CNT electrodes and clearly detect molecules. Moreover, by modifying the CNT electrodes with enzyme glucose oxidase, glucose molecules could be detected using our chips by cyclic voltammetry and chronoamperometry. We conclude that microfluidic chips with CNT-arrayed electrodes are a promising candidate for the development of hand-held electrochemical biosensors.

  15. Performance characteristics of valveless and cantilever-valve micropump

    Science.gov (United States)

    Shukur, A. F. M.; Sabani, N.; Taib, B. N.; Azidin, M. A. M.; Shahimin, M. M.

    2013-12-01

    This paper presents comparison between two classes of micropump which are valveless micropump and cantilever-valve micropump. These micropumps consist of basic components which are diaphragm, pumping chamber, actuation mechanism, inlet and outlet. Piezoelectric actuation is carried out by applying pressure on the micropump diaphragm to produce deflection. The micropumps studied in this paper had been designed with specific diaphragm thickness and diameter; while varying the materials, pressure applied and liquid types used. The outer dimension for both micropumps is 4mm × 4mm × 0.5mm with diameter and thickness of the diaphragm are 3.8mm and 20μm respectively. Valveless micropump was shown in this paper to have better performance in mechanical and fluid analysis in terms of maximum deflection and maximum flow rate at actuation pressure 30kPa vis-à-vis cantilever-valve micropump. Valveless micropump was shown in this study to have maximum diaphragm deflection of 183.06μm and maximum flow rate with 191.635μL/s at actuation pressure 30kPa using silicon dioxide as material.

  16. High precision innovative micropump for artificial pancreas

    Science.gov (United States)

    Chappel, E.; Mefti, S.; Lettieri, G.-L.; Proennecke, S.; Conan, C.

    2014-03-01

    The concept of artificial pancreas, which comprises an insulin pump, a continuous glucose meter and a control algorithm, is a major step forward in managing patient with type 1 diabetes mellitus. The stability of the control algorithm is based on short-term precision micropump to deliver rapid-acting insulin and to specific integrated sensors able to monitor any failure leading to a loss of accuracy. Debiotech's MEMS micropump, based on the membrane pump principle, is made of a stack of 3 silicon wafers. The pumping chamber comprises a pillar check-valve at the inlet, a pumping membrane which is actuated against stop limiters by a piezo cantilever, an anti-free-flow outlet valve and a pressure sensor. The micropump inlet is tightly connected to the insulin reservoir while the outlet is in direct communication with the patient skin via a cannula. To meet the requirement of a pump dedicated to closed-loop application for diabetes care, in addition to the well-controlled displacement of the pumping membrane, the high precision of the micropump is based on specific actuation profiles that balance effect of pump elasticity in low-consumption push-pull mode.

  17. LIQUID-SOLID COUPLED SYSTEM OF MICROPUMP

    Institute of Scientific and Technical Information of China (English)

    Wu Jiankang; Lu Lijun

    2006-01-01

    This paper employs the integral-averaged method of thickness to approximate the periodical flows in a piezoelectric micropump, with a shallow water equation including nonlinearity and viscous damp presented to characterize the flows in micropump. The finite element method is used to obtain a matrix equation of fluid pressure. The fluid pressure equation is combined with the vibration equation of a silicon diaphragm to construct a liquid-solid coupled equation for reflecting the interaction between solid diaphragm and fluid motion in a micropump. Numerical results of a mode analysis of the coupled system indicate that the natural frequencies of the coupled system are much lower than those of the non-coupled system. The influence of additional mass and viscous damp of fluid on the natural frequencies of the coupled system is more significant as the pump thickness is small. It is found that the vibration shape functions of silicon diaphragm of the coupled system are almost the same as those of the non-coupled system. This paper also gives the first-order amplitude-frequency relationship of the silicon diaphragm, which is necessary for the flow-rate-frequency analysis of a micropump.

  18. Modular Architecture of a Non-Contact Pinch Actuation Micropump

    OpenAIRE

    Ruzairi Abdul Rahim; Pei Ling Leow; Uda Hashim; Tijjani Adam; Rashidah Arsat; Pei Song Chee

    2012-01-01

    This paper demonstrates a modular architecture of a non-contact actuation micropump setup. Rapid hot embossing prototyping was employed in micropump fabrication by using printed circuit board (PCB) as a mold material in polymer casting. Actuator-membrane gap separation was studied, with experimental investigation of three separation distances: 2.0 mm, 2.5 mm and 3.5 mm. To enhance the micropump performance, interaction surface area between plunger and membrane was modeled via finite element a...

  19. Surface micromachined electrostatically actuated micro peristaltic pump

    OpenAIRE

    Xie, Jun; Shih, Jason; Lin, Qiao; Yang, Bozhi; Tai, Yu-Chong

    2004-01-01

    An electrostatically actuated micro peristaltic pump is reported. The micro pump is entirely surface micromachined using a multilayer parylene technology. Taking advantage of the multilayer technology, the micro pump design enables the pumped fluid to be isolated from the electric field. Electrostatic actuation of the parylene membrane using both DC and AC voltages was demonstrated and applied to fluid pumping based on a 3-phase peristaltic sequence. A maximum flow rate of 1.7 nL min^–1 and a...

  20. Wettability-gradient-driven micropump for transporting discrete liquid drops

    International Nuclear Information System (INIS)

    In this paper, we report our efforts toward building a microelectromechanical system-based micropump. The micropump is driven by a wettability gradient and used to transport discrete drops. The gradient in wettability is distributed axisymmetrically, with hydrophobicity of the micropump surface decreasing radially toward the center. Both physical and chemical properties of the surface are altered to obtain the wettability gradient needed for driving the drops. The surface of the micropump is, first, patterned with pre-designed micro-features that define the roughness of the surface and, then, coated with a low-energy interface film. Results show that drops deposited on the surface of the micropump move, in a directional way, along the wettability gradient. The average velocity of the deposited drops is 5 mm s−1. Measured contact angles decrease gradually from 157.0° to 124.2° toward the center of the micropump surface. Maximum driving force exerted by the solid surface on the drops is 12.82 µN. The average size of the drops transported on the surface of the micropump is 2 µL. (paper)

  1. Linear peristaltic pump based on electromagnetic actuators

    Directory of Open Access Journals (Sweden)

    Maddoui Lotfi

    2014-01-01

    Full Text Available In this paper a study and design of a linear peristaltic pump are presented. A set of electromagnetic (solenoid actuators is used as the active tools to drag the liquid by crushing an elastic tube. The pump consists of six serially-connected electromagnetic actuators controlled via an electronic board. This may be considered as a simulated peristalsis action of intestines. The dynamic performances of the pump are investigated analytically and experimentally.

  2. Continuous dynamic flow micropumps for microfluid manipulation

    International Nuclear Information System (INIS)

    Recent years have seen considerable progress in the development of microfabricated systems for use in the chemical and biological sciences. The term micro total analytical system (µTAS) is now a well-accepted concept. Much development has been driven by a need to perform effective manipulation of chemical and biological liquids with small volumes at micro and/or nano flowrate level in these systems. In this review, the focus will be on the pumping techniques used for delivery and control of liquids, especially those physical-chemical 'continuous dynamic flow micropumps'. The principles of these pumping techniques are mainly based on one or several well-known phenomena such as electrical, light, magnetic, thermal and other actuated mechanisms. Electrokinetically-driven continuous flow pumps such as the electrophoretic pump and electroosmotic pump, surface chemistry based continuous flow micropumps such as the opto-electrowetting-based pump, optically-driven pump, electrochemical pump and constant gravity-driven pump, and combination-driven techniques such as hydrodynamic flow and electrokinetic/gravity/magnetophoretic pumping will be summarized. The focus will be on the research highlights, trends and future of these pump techniques. Finally, mixing techniques on the microscale are briefly reviewed. (topical review)

  3. The dynamic characteristics of a valve-less micropump

    Institute of Scientific and Technical Information of China (English)

    Jiang Dan; Li Song-Jing

    2012-01-01

    The aim of this paper is to investigate the dynamic characteristics of a valve-less micropump.A dynamic mathematical model of the micropump based on a hydraulic analogue system and a simulation method using AMESim software are developed.By using the finite-element analysis method,the static analysis of the diaphragm is carried out to obtain the maximum deflection and volumetric displacement.Dynamic characteristics of the valve-less micropump under different excitation voltages and frequencies are simulated and tested.Because of the discrepancy between simulation results and experimental data at frequencies other than the natural frequency,the revised model for the diaphragm maximum volumetric displacement is presented.Comparison between the simulation results based on the revised model and experimental data shows that the dynamic mathematical model based on the hydraulic analogue system is capable of predicting dynamic characteristics of the valve-less micropump at any excitation voltage and frequency.

  4. A global assessment of piezoelectric actuated micro-pumps

    OpenAIRE

    Hernandez, C.; Bernard, Y; Razek, A.

    2010-01-01

    Abstract This article provides an extensive outlook of different types of piezoelectric actuated micro-pumps published in the literature recently. We start by reminding the reader about the conventional operating parameters used to quantify the capabilities of these devices. After this introductory stage, we describe and classify the most prominent micro-pump's geometries found with piezoelectric actuation. At this point we identify the parameters given ...

  5. Design and modeling of a light powered biomimicry micropump

    Science.gov (United States)

    Sze, Tsun-kay Jackie; Liu, Jin; Dutta, Prashanta

    2015-06-01

    The design of compact micropumps to provide steady flow has been an on-going challenge in the field of microfluidics. In this work, a novel micropump concept is introduced utilizing bacteriorhodopsin and sugar transporter proteins. The micropump utilizes light energy to activate the transporter proteins, which create an osmotic pressure gradient and drive the fluid flow. The capability of the bio inspired micropump is demonstrated using a quasi 1D numerical model, where the contributions of bacteriorhodopsin and sugar transporter proteins are taken care of by appropriate flux boundary conditions in the flow channel. Proton flux created by the bacteriorhodopsin proteins is compared with experimental results to obtain the appropriate working conditions of the proteins. To identify the pumping capability, we also investigate the influences of several key parameters, such as the membrane fraction of transporter proteins, membrane proton permeability and the presence of light. Our results show that there is a wide bacteriorhodopsin membrane fraction range (from 0.2 to 10%) at which fluid flow stays nearly at its maximum value. Numerical results also indicate that lipid membranes with low proton permeability can effectively control the light source as a method to turn on/off fluid flow. This capability allows the micropump to be activated and shut off remotely without bulky support equipment. In comparison with existing micropumps, this pump generates higher pressures than mechanical pumps. It can produce peak fluid flow and shutoff head comparable to other non-mechanical pumps.

  6. Peristaltic pumps work in nano scales

    OpenAIRE

    Farahpour, Farnoush; Ejtehadi, Mohammad Reza

    2013-01-01

    A design for a pump is suggested which is based on well-known peristaltic pumps. In order to simply describe the operation of the proposed pump, an innovative interpretation of low Reynolds number swimmers is presented and thereafter a similar theoretical model would be suggested to quantify the behavior of the pumps. A coarse-grained molecular dynamic simulation is used to examine the theoretical predictions and measure the efficiency of the pump in nano scales. It is shown that this pump wi...

  7. Peristaltic Transport through Eccentric Cylinders: Mathematical Model

    Directory of Open Access Journals (Sweden)

    Kh. S. Mekheimer

    2013-01-01

    Full Text Available This paper discusses the effect of peristaltic transport on the fluid flow in the gap between two eccentric tubes (eccentric-annulus flows. The inner tube is uniform, rigid, while the outer tube has a sinusoidal wave traveling down its wall. The flow analysis has been developed for low Reynolds number and long wave length approximation. The velocity and the pressure gradient have been obtained in terms of the dimensionless flow rate Q¯, time t, azimuthal coordinate θ and eccentricity parameter ϵ (the parameter that controls of the eccentricity of the inner tube position. The results show that there is a significant deference between eccentric and concentric annulus flows.

  8. Geometrical tuning of microdiffuser/nozzle for valveless micropumps

    International Nuclear Information System (INIS)

    Valveless micropumps require the integration of microdiffusers/nozzles for flow rectification in microfluidic systems. The flow directing capability of a micropump is determined by the efficiency of the diffuser. With the reduction in size of the micropump, conventional microdiffuser geometrical parameters are not suitable for obtaining high flow efficiencies due to several fluidic effects such as channel friction, wall shear stress, vena contracta, etc, and therefore it is important to modify the diffuser geometry according to the requirements of the pressure coefficients in order to obtain improved flow rates. This paper presents a simple and microfabrication friendly geometrical tuning method which offers the user a broad range of dependent tunable geometric parameters to improve the performance of the microdiffuser for valveless micropumps. Herein, for a given flow condition, the flow behaviour and the variation of pressure coefficients of the microdiffuser/nozzle with geometric tuning have been studied for different diffuser angles using finite element modelling (FEM). The results show that the proposed method is highly suitable for tuning the geometry of microdiffusers for a wide range of operating conditions of valveless micropumps. The performances of the best diffuser geometries for different diffuser angles have been experimentally verified, and the test results are used for the validation of the results of the FEM. The comparison between the FEM and experimental results shows a close agreement.

  9. Piezoelectric diffuser/nozzle micropump with double pump chambers

    Institute of Scientific and Technical Information of China (English)

    Wei WANG; Ying ZHANG; Li TIAN; Xiaojie CHEN; Xiaowei LIU

    2008-01-01

    To eliminate check valve fatigue and valve clogging, diffuser/nozzle elements are used for flow rec-tification in a valveless diffuser/nozzle micropump instead of valves. However, the application of this type of micro-pump is restricted because of its pulsating or periodic flow and low pump flux. In this paper, a diffuser/nozzle Si/ Glass micropump with two pump chambers by IC and MEMS technology is designed. The fabrication process requires only one mask and one etch step, so that the fabrication has the advantages of low cost, short proces-sing period, and facilitation of miniaturization. The pump is equipped with a glass cover board so as to conveniently observe the flow status. Pump-chambers and diffuser ele-ments are fabricated by the anisotropic KOH-etch tech-nique on the silicone substrate, and the convex corner is designed to compensate for an anisotropic etch. The driv-ing force of the micropump is produced by the PZT piezo-electric actuator, The pump performance with both actuators actuated in anti- or same-phase mode is also researched. The result indicates that the micropump achieves great performance with the actuators working at anti-phase. This may be because the liquid flows stead-ily, pulse phenomenon is very weak, and the optimal working frequency, pump back pressure, and flow rate are both double that of the pump driven in same-phase.

  10. A linear peristaltic MRF/foam actuator

    Science.gov (United States)

    Larsen, J. J.; Jenkins, C. H.; Korde, U. A.

    2007-04-01

    , peristaltic pumps in industry are common for a variety of material handling applications, particularly involving the movement of sterile fluids (for example, blood). The peristaltic pump is usually circular in configuration, relying on external rollers to move fluid within a tube. Some linear configuration pumps have been proposed and developed, however they are complicated than their circular counterparts. In the remaining part of the present work, we discuss the development of a linear peristaltic actuator based upon the deformation of MRF/foam. The actuator consists of an open-cell polymer foam substrate infused with MRF. To one side of the foam substrate resides a translating magnet, such that a magnetic field can be propagated down its length. The linear peristaltic action is generated as the transversely propagating field shapes the MRF/foam substrate in a corresponding way. Experimental results are discussed, an outline of on-going theoretical modeling is presented, and conclusions are provided.

  11. Swimming and peristaltic pumping between two plane parallel walls

    International Nuclear Information System (INIS)

    Swimming at low Reynolds number in a fluid confined between two plane walls is studied for an infinite plane sheet located midway between the walls and distorted with a transverse propagating wave. It is shown that the flow pattern is closely related to that for peristaltic pumping. The hydrodynamic interaction between two flexible sheets swimming parallel in infinite space is related to the problem of peristaltic pumping in a planar channel with two wavy walls.

  12. Analysis, design and experimental characterization of electrostatically actuated gas micropumps

    Science.gov (United States)

    Astle, Aaron A.

    This work goal is to realize a high-performance, multi-stage micropump integrated within a wireless micro gas chromatograph (muGC) for measuring airborne environment pollutants. The work described herein focuses on the development of high-fidelity mathematical and physical design models, and the testing and validation of the most promising models with large-scale and micro-scale (MEMS) pump prototypes. It is shown that an electrostatically-actuated, multistage, diaphragm micropump with active valve control provides the best expected performance for this application. A hierarchy of models is developed to characterize the various factors governing micropump performance. This includes a thermodynamic model, an idealized reduced-order model and a reduced-order model that incorporates realistic valve flow effects and accounts for fluidic load. The reduced-order models are based on fundamental fluid dynamic principles and allow predictions of flow rate and pressure rise as a function of geometric design variables, and drive signal. The reduced order models are validated in several tests. Two-stage, 20x scale pump results reveal the need to incorporate realistic valve flow effects and the output load for accurate modeling. The more realistic reduced order model is then validated using micropumps with two and four pumping stages. The reduced order model captures the micropump performance accurately, provided that separate measurements of valve pressure losses and pump geometry are used. The four-stage micropump fabricated using theoretical model guidelines from this research provides a maximum flow rate and pressure rise of 3 cm 3/min and 1.75 kPa/stage respectively with a power consumption of only 4 mW per stage. The four-stage micropump occupies and area of 54 mm 2. Each pumping cavity has a volume of 6x10-6 m 3. This performance indicates that this pump design will be sufficient to meet the requirements for extended field operation of a wireless integrated muGC. During

  13. Valveless Thermally-Driven Phase-Change Micropump

    Institute of Scientific and Technical Information of China (English)

    王沫然; 李志信

    2004-01-01

    A dynamic model with moving heat sources was developed to analyze the pumping mechanism of a valveless thermally-driven phase-change micropump. The coupled equations were solved to determine the pumping characteristics. The numerical results agree with experimental data from micropumps with different diameter microtubes. The maximum flow rate reached 33 μL / min and the maximum pump pressure was over 20 kPa for a 200-μm diameter microtube. Analysis of the pumping mechanism shows that the main factors affecting the flow come from the large density difference between the liquid and vapor phases and the choking effect of the vapor region.

  14. Modular Architecture of a Non-Contact Pinch Actuation Micropump

    Directory of Open Access Journals (Sweden)

    Ruzairi Abdul Rahim

    2012-09-01

    Full Text Available This paper demonstrates a modular architecture of a non-contact actuation micropump setup. Rapid hot embossing prototyping was employed in micropump fabrication by using printed circuit board (PCB as a mold material in polymer casting. Actuator-membrane gap separation was studied, with experimental investigation of three separation distances: 2.0 mm, 2.5 mm and 3.5 mm. To enhance the micropump performance, interaction surface area between plunger and membrane was modeled via finite element analysis (FEA. The micropump was evaluated against two frequency ranges, which comprised a low driving frequency range (0–5 Hz, with 0.5 Hz step increments and a nominal frequency range (0–80 Hz, with 10 Hz per step increments. The low range frequency features a linear relationship of flow rate with the operating frequency function, while two magnitude peaks were captured in the flow rate and back pressure characteristic in the nominal frequency range. Repeatability and reliability tests conducted suggest the pump performed at a maximum flow rate of 5.78 mL/min at 65 Hz and a backpressure of 1.35 kPa at 60 Hz.

  15. A high current density DC magnetohydrodynamic (MHD) micropump

    NARCIS (Netherlands)

    Homsy, Alexandra; Koster, Sander; Eijkel, Jan C.T.; Berg, van den Albert; Lucklum, F.; Verpoorte, E.; Rooij, de Nico F.

    2005-01-01

    This paper describes the working principle of a DC magnetohydrodynamic (MHD) micropump that can be operated at high DC current densities (J) in 75-µm-deep microfluidic channels without introducing gas bubbles into the pumping channel. The main design feature for current generation is a micromachined

  16. A high current density DC magnetohydrodynamic (MHD) micropump

    NARCIS (Netherlands)

    Homsy, A; Koster, Sander; Eijkel, JCT; van den Berg, A; Lucklum, F; Verpoorte, E; de Rooij, NF

    2005-01-01

    This paper describes the working principle of a DC magnetohydrodynamic (MHD) micropump that can be operated at high DC current densities (J) in 75-mu m-deep microfluidic channels without introducing gas bubbles into the pumping channel. The main design feature for current generation is a micromachin

  17. Optofluidic modulator based on peristaltic nematogen microflows

    Science.gov (United States)

    Cuennet, J. G.; Vasdekis, A. E.; de Sio, L.; Psaltis, D.

    2011-04-01

    Nematogens rotate by the application of external fields, thereby enabling optical modulation. This principle has had a profound impact on our daily lives through the plethora of liquid-crystal displays in use around us. However, the wider use of nematic liquid crystals, particularly in microdisplays and information processing, has been hampered by their slow response times. In nematogens, rotational and translational molecular motions are coupled, so flow is inevitably linked with optical modulation. This linkage motivated us to fuse microfluidics with anisotropic liquids and introduce an optofluidic modulator that exhibits a submillisecond (250 µs) symmetric response and can operate at frequencies up to 1 kHz. The modulator is based on peristaltic nematogen microflows realized in polydimethylsiloxane microfluidics. The latter simultaneously permits peristalsis by means of elastomeric deformation, nematogen alignment and rapid prototyping through cast-moulding. Together with large-scale, vertical integration and piezoelectric nanotechnologies, this optofluidic paradigm can enable high-density and three-dimensional architectures of fast modulators.

  18. A magnetically driven PDMS micropump with ball check-valves

    Science.gov (United States)

    Pan, Tingrui; McDonald, Scott J.; Kai, Eleanor M.; Ziaie, Babak

    2005-05-01

    In this paper, we present a low-cost, PDMS-membrane micropump with two one-way ball check-valves for lab-on-a-chip and microfluidic applications. The micropump consists of two functional PDMS layers, one holding the ball check-valves and an actuating chamber, and the other covering the chamber and holding a miniature permanent magnet on top for actuation. An additional PDMS layer is used to cover the top magnet, and thereby encapsulate the entire device. A simple approach was used to assemble a high-performance ball check-valve using a micropipette and heat shrink tubing. The micropump can be driven by an external magnetic force provided by another permanent magnet or an integrated coil. In the first driving scheme, a small dc motor (6 mm in diameter and 15 mm in length) with a neodymium-iron-boron permanent magnet embedded in its shaft was used to actuate the membrane-mounted magnet. This driving method yielded a large pumping rate with very low power consumption. A maximum pumping rate of 774 µL min-1 for deionized water was achieved at the input power of 13 mW, the highest pumping rate reported in the literature for micropumps at such power consumptions. Alternatively, we actuated the micropump with a 10-turn planar coil fabricated on a PC board. This method resulted in a higher pumping rate of 1 mL min-1 for deionized water. Although more integratable and compact, the planar microcoil driving technique has a much higher power consumption.

  19. Dielectric elastomer peristaltic pump module with finite deformation

    Science.gov (United States)

    Mao, Guoyong; Huang, Xiaoqiang; Liu, Junjie; Li, Tiefeng; Qu, Shaoxing; Yang, Wei

    2015-07-01

    Inspired by various peristaltic structures existing in nature, several bionic peristaltic actuators have been developed. In this study, we propose a novel dielectric elastomer peristaltic pump consisting of short tubular modules, with the saline solution as the electrodes. We investigate the performance of this soft pump module under hydraulic pressure and voltage via experiments and an analytical model based on nonlinear field theory. It is observed that the individual pump module undergoes finite deformation and may experience electromechanical instability during operations. The driving pressure and displaced volume of the peristaltic pump module can be modulated by applied voltage. The efficiency of the pump module is enhanced by alternating current voltage, which can suppress the electromechanical pull-in instability. An analytical model is developed within the framework of the nonlinear field theory, and its predictive capacity is checked by experimental observations. The effects of the prestretch, aspect ratio, and voltage on the performance of the pump modules are characterized by the analytical model. This work can guide the designs of soft active peristaltic pumps in the field of artificial organs and industrial conveying systems.

  20. Optimization design of multi-material micropump using finite element method

    OpenAIRE

    Zhu, Meiling; Kirby, Paul B.; Wacklerle, M.; Herz, M; Richter, M.

    2009-01-01

    This paper presents a micropump fabricated from low-cost materials with specific goal of cost reduction. The micropump does not require any valve flap and comprises of one plastic pump polyether-ether-ketone (PEEK) body, one metal diaphragm, and three piezoelectric ceramics to form piezoelectrically actuated diaphragm valves. The valve actuation simplifies micropump structural designs and assembly processes to make the pump attractive for low cost bio-medical drug delivery a...

  1. Postprandial transduodenal bolus transport is regulated by complex peristaltic sequence

    Institute of Scientific and Technical Information of China (English)

    Huan Nam Nguyen; Ron Winograd; Gerson Ricardo Souza Domingues; Frank Lammert

    2006-01-01

    AIM: To study the relationship between the patterns of postprandial peristalsis and transduodenal bolus transport in healthy subjects.METHODS: Synchronous recording of chyme transport and peristaltic activity was performed during the fasting state and after administration of a test meal using a special catheter device with cascade configuration of impedance electrodes and solid-state pressure transducers. The catheter was placed into the duodenum,where the first channel was located in the first part of the duodenum and the last channel at the duodenojejunal junction. After identification of previously defined chyme transport patterns the associated peristaltic patterns were analyzed.RESULTS: The interdigestive phase 3 complex was reliably recorded with both techniques. Of 497 analyzed impedance bolus transport events, 110 (22%) were short-spanned propulsive, 307 (62%) long-spanned propulsive, 70 (14%)complex propulsive, and 10 (2%) retrograde transport.Short-spanned chyme transports were predominantly associated with stationary or propagated contractions propagated over short distance. Long-spanned and complex chyme transports were predominantly associated with propulsive peristaltic patterns, which were frequently complex and comprised multiple contractions. Propagated double wave contraction, propagated contraction with a clustered contraction, and propagated cluster of contractions have been identified to be an integralted part of a peristaltic sequence in human duodenum.CONCLUSION: Combined impedancometry andmanometry improves the analysis of the peristaltic patterns that are associated with postprandial transduodenal chyme transport. Postprandial transduodenal bolus transport is regulated by propulsive peristaltic patterns, which are frequently complex but well organized. This finding should be taken into consideration in the analysis of intestinal motility studies.

  2. Heat Transfer Analysis for Peristaltic Mechanism in Variable Viscosity Fluid

    Institute of Scientific and Technical Information of China (English)

    T.Hayat; F.M.Abbasi; Awatif A.Hendi

    2011-01-01

    An analysis is carried out for a peristaltic flow of a third-order fluid with heat transfer and variable viscosity when no-slip condition does not hold. Perturbation solution is discussed and a comparative study between the cases of constant and variable viscosities is presented and analyzed.%@@ An analysis is carried out for a peristaltic flow of a third-order fluid with heat transfer and variable viscosity when no-slip condition does not hold.Perturbation solution is discussed and a comparative stuity between the cases of constant and variable viscosities is presented and analyzed.

  3. Concepts for a new class of all-polymer micropumps.

    Science.gov (United States)

    Loverich, Jacob J; Kanno, Isaku; Kotera, Hidetoshi

    2006-09-01

    This paper presents a polymer-based micropump addressing the cost, performance, and system compatibility issues that have limited the integration of on-chip micropumps into microanalysis systems. This pump uses dielectric elastomer actuation to periodically displace fluid, and a pair of elastomeric check valves to rectify the fluid's resulting movement. Its significant features include the use of a transparent substrate, self-priming capability, insensitivity to gas bubbles, and the ability to admit particles. A pump occupying less than 10 mm2 of chip space produced a 77 microl min(-1) flow rate. The pump has a high thermodynamic efficiency and exhibits little performance degradation over 10 hours of operation. In addition to its notable performance, the pump can be fabricated at low cost and directly integrated into microfluidic chips that use planar softlithography-formed structures. The new pump concept, fabrication, and experimental performance are discussed herein. PMID:16929393

  4. A novel reciprocating micropump based on Lorentz force

    Science.gov (United States)

    Salari, Alinaghi; Hakimsima, Abbas; Shafii, Mohammad Behshad

    2015-03-01

    Lorentz force is the pumping basis of many electromagnetic micropumps used in lab-on-a-chip. In this paper a novel reciprocating single-chamber micropump is proposed, in which the actuation technique is based on Lorentz force acting on an array of microwires attached on a membrane surface. An alternating current is applied through the microwires in the presence of a magnetic field. The resultant force causes the membrane to oscillate and pushes the fluid to flow through microchannel using a ball-valve. The pump chamber (3 mm depth) was fabricated on a Polymethylmethacrylate (PMMA) substrate using laser engraving technique. The chamber was covered by a 60 μm thick hyper-elastic latex rubber diaphragm. Two miniature permanent magnets capable of providing magnetic field of 0.09 T at the center of the diaphragm were mounted on each side of the chamber. Square wave electric current with low-frequencies was generated using a function generator. Cylindrical copper microwires (250 μm diameter and 5 mm length) were attached side-by-side on top surface of the diaphragm. Thin loosely attached wires were used as connectors to energize the electrodes. Due to large displacement length of the diaphragm (~3 mm) a high efficiency (~90%) ball valve (2 mm diameter stainless steel ball in a tapered tubing structure) was used in the pump outlet. The micropump exhibits a flow rate as high as 490 μl/s and pressure up to 1.5 kPa showing that the pump is categorized among high-flow-rate mechanical micropumps.

  5. Peristaltic pump-based low range pressure sensor calibration system

    Science.gov (United States)

    Vinayakumar, K. B.; Naveen Kumar, G.; Nayak, M. M.; Dinesh, N. S.; Rajanna, K.

    2015-11-01

    Peristaltic pumps were normally used to pump liquids in several chemical and biological applications. In the present study, a peristaltic pump was used to pressurize the chamber (positive as well negative pressures) using atmospheric air. In the present paper, we discuss the development and performance study of an automatic pressurization system to calibrate low range (millibar) pressure sensors. The system includes a peristaltic pump, calibrated pressure sensor (master sensor), pressure chamber, and the control electronics. An in-house developed peristaltic pump was used to pressurize the chamber. A closed loop control system has been developed to detect and adjust the pressure leaks in the chamber. The complete system has been integrated into a portable product. The system performance has been studied for a step response and steady state errors. The system is portable, free from oil contaminants, and consumes less power compared to existing pressure calibration systems. The veracity of the system was verified by calibrating an unknown diaphragm based pressure sensor and the results obtained were satisfactory.

  6. Peristaltic pump-based low range pressure sensor calibration system

    International Nuclear Information System (INIS)

    Peristaltic pumps were normally used to pump liquids in several chemical and biological applications. In the present study, a peristaltic pump was used to pressurize the chamber (positive as well negative pressures) using atmospheric air. In the present paper, we discuss the development and performance study of an automatic pressurization system to calibrate low range (millibar) pressure sensors. The system includes a peristaltic pump, calibrated pressure sensor (master sensor), pressure chamber, and the control electronics. An in-house developed peristaltic pump was used to pressurize the chamber. A closed loop control system has been developed to detect and adjust the pressure leaks in the chamber. The complete system has been integrated into a portable product. The system performance has been studied for a step response and steady state errors. The system is portable, free from oil contaminants, and consumes less power compared to existing pressure calibration systems. The veracity of the system was verified by calibrating an unknown diaphragm based pressure sensor and the results obtained were satisfactory

  7. Long Wavelength Peristaltic Transport of Non-Newton Fluids

    OpenAIRE

    Devanathan, R; Parvathamma, S.

    1980-01-01

    Solutions are obtained for the stream function and the pressure field for the flow of non-Newtonian fluids in a tube by long peristaltic waves of arbitrary shape. The axial velocity profiles and stress distributions on the wall are discussed for particular waves of some practical interest. The effect of non- Newtonian character of the fluid is examined.

  8. Electroosmosis-modulated peristaltic transport in microfluidic channels

    Science.gov (United States)

    Bandopadhyay, Aditya; Tripathi, Dharmendra; Chakraborty, Suman

    2016-05-01

    We analyze the peristaltic motion of aqueous electrolytes altered by means of applied electric fields. Handling electrolytes in typical peristaltic channel material such as polyvinyl chloride and Teflon leads to the generation of a net surface charge on the channel walls, which attracts counter-ions and repels co-ions from the aqueous solution, thus leading to the formation of an electrical double layer—a region of net charges near the wall. We analyze the spatial distribution of pressure and wall shear stress for a continuous wave train and single pulse peristaltic wave in the presence of an electrical (electroosmotic) body force, which acts on the net charges in the electrical double layer. We then analyze the effect of the electroosmotic body force on the particle reflux as elucidated through the net displacement of neutrally buoyant particles in the flow as the peristaltic waves progress. The impact of combined electroosmosis and peristalsis on trapping of a fluid volume (e.g., bolus) inside the travelling wave is also discussed. The present analysis goes beyond the traditional analysis, which neglects the possibility of coupling the net pumping of fluids due to peristalsis and allows us to derive general expressions for the pressure drop and flow rate in order to set up a general framework for incorporating flow control and actuation by simultaneous peristalsis and application of electric fields to aqueous solutions. It is envisaged that the results presented here may act as a model for the design of lab-on-a-chip devices.

  9. Peristaltic pump-based low range pressure sensor calibration system.

    Science.gov (United States)

    Vinayakumar, K B; Naveen Kumar, G; Nayak, M M; Dinesh, N S; Rajanna, K

    2015-11-01

    Peristaltic pumps were normally used to pump liquids in several chemical and biological applications. In the present study, a peristaltic pump was used to pressurize the chamber (positive as well negative pressures) using atmospheric air. In the present paper, we discuss the development and performance study of an automatic pressurization system to calibrate low range (millibar) pressure sensors. The system includes a peristaltic pump, calibrated pressure sensor (master sensor), pressure chamber, and the control electronics. An in-house developed peristaltic pump was used to pressurize the chamber. A closed loop control system has been developed to detect and adjust the pressure leaks in the chamber. The complete system has been integrated into a portable product. The system performance has been studied for a step response and steady state errors. The system is portable, free from oil contaminants, and consumes less power compared to existing pressure calibration systems. The veracity of the system was verified by calibrating an unknown diaphragm based pressure sensor and the results obtained were satisfactory. PMID:26628178

  10. Peristaltic pump-based low range pressure sensor calibration system

    Energy Technology Data Exchange (ETDEWEB)

    Vinayakumar, K. B. [Department of Instrumentation and Applied Physics, Indian Institute of Science, Bangalore 5600012 (India); Department of Electronic Systems Engineering, Indian Institute of Science, Bangalore 5600012 (India); Naveen Kumar, G.; Rajanna, K., E-mail: kraj@isu.iisc.ernet.in, E-mail: krajanna2011@gmail.com [Department of Instrumentation and Applied Physics, Indian Institute of Science, Bangalore 5600012 (India); Nayak, M. M. [Centre for Nano Science and Engineering, Indian Institute of Science, Bangalore 5600012 (India); Dinesh, N. S. [Department of Electronic Systems Engineering, Indian Institute of Science, Bangalore 5600012 (India)

    2015-11-15

    Peristaltic pumps were normally used to pump liquids in several chemical and biological applications. In the present study, a peristaltic pump was used to pressurize the chamber (positive as well negative pressures) using atmospheric air. In the present paper, we discuss the development and performance study of an automatic pressurization system to calibrate low range (millibar) pressure sensors. The system includes a peristaltic pump, calibrated pressure sensor (master sensor), pressure chamber, and the control electronics. An in-house developed peristaltic pump was used to pressurize the chamber. A closed loop control system has been developed to detect and adjust the pressure leaks in the chamber. The complete system has been integrated into a portable product. The system performance has been studied for a step response and steady state errors. The system is portable, free from oil contaminants, and consumes less power compared to existing pressure calibration systems. The veracity of the system was verified by calibrating an unknown diaphragm based pressure sensor and the results obtained were satisfactory.

  11. SU8 diaphragm micropump with monolithically integrated cantilever check valves.

    Science.gov (United States)

    Ezkerra, Aitor; Fernández, Luis José; Mayora, Kepa; Ruano-López, Jesús Miguel

    2011-10-01

    This paper presents a SU8 unidirectional diaphragm micropump with embedded out-of-plane cantilever check valves. The device represents a reliable and low-cost solution for integration of microfluidic control in lab-on-a-chip devices. Its planar architecture allows monolithic definition of its components in a single step and potential integration with previously reported PCR, electrophoresis and flow-sensing SU8 microdevices. Pneumatic actuation is applied on a PDMS diaphragm, which is bonded to the SU8 body at wafer level, further enhancing its integration and mass production capabilities. The cantilever check valves move synchronously with the diaphragm, feature fast response (10ms), low dead volume (86nl) and a 94% flow blockage up to 300kPa. The micropump achieves a maximum flow rate of 177 μl min(-1) at 6 Hz and 200 kPa with an effective area of 10 mm(2). The device is reliable, self-priming and tolerant to particles and big bubbles. To the knowledge of the authors, this is the first micropump in SU8 with monolithically integrated cantilever check valves. PMID:21853192

  12. A polymer chip-integrable piezoelectric micropump with low backpressure dependence

    DEFF Research Database (Denmark)

    Conde, A. J.; Bianchetti, A.; Veiras, F. E.;

    2015-01-01

    We describe a piezoelectric micropump constructed in polymers with conventional machining methods. The micropump is self-contained and can be built as an independent device or as an on-chip module within laminated microfluidic chips. We demonstrate on-chip integrability by the fabrication...

  13. Development of a solenoid actuated planar valveless micropump with single and multiple inlet–outlet arrangements

    Science.gov (United States)

    Kumar, N.; George, D.; Sajeesh, P.; Manivannan, P. V.; Sen, A. K.

    2016-07-01

    We report a planar solenoid actuated valveless micropump with multiple inlet–outlet configurations. The self-priming characteristics of the multiple inlet–multiple outlet micropump are studied. The filling dynamics of the micropump chamber during start-up and the effects of fluid viscosity, voltage and frequency on the dynamics are investigated. Numerical simulations for multiple inlet–multiple outlet micropumps are carried out using fluid structure algorithm. With DI water and at 5.0 Vp-p, 20 Hz frequency, the two inlet–two outlet micropump provides a maximum flow rate of 336 μl min‑1 and maximum back pressure of 441 Pa. Performance characteristics of the two inlet–two outlet micropump are studied for aqueous fluids of different viscosity. Transport of biological cell lines and diluted blood samples are demonstrated; the flow rate-frequency characteristics are studied. Viability of cells during pumping with multiple inlet multiple outlet configuration is also studied in this work, which shows 100% of cells are viable. Application of the proposed micropump for simultaneous pumping, mixing and distribution of fluids is demonstrated. The proposed integrated, standalone and portable micropump is suitable for drug delivery, lab-on-chip and micro-total-analysis applications.

  14. A Numerical Investigation of Peristaltic Waves in Circular Tubes

    Science.gov (United States)

    Xiao, Q.; Damodaran, M.

    Peristaltic pumping is a process of fluid transport arising from the progressive waves, which travel along the walls of a flexible channel. It is a primary physiological transport mechanism that is inherent in many tubular organs of the human body such as the ureter, the gastro-intestinal tract, the urethra, and so on. Many studies exist in literature with the aim of understanding the characteristics of peristaltic flow under the assumption of low Reynolds number and infinitely long wavelength in a two-dimensional channel. However, peristaltic pumping is also the mechanism used in other industrial applications such as the blood pump for which the Reynolds number has a moderately high value. As studies concerning moderate to high Reynolds number flow in the circular tube are rare in literature, in the present study, the peristaltic flow of an incompressible fluid is numerically simulated using the finite volume method for solving the incompressible Navier-Stokes equations in primitive variable formulation by means of an infinite train of sinusoidal waves traveling along the wall of an axi-symmetric tube. The computational model presented in this work covers a wider range of Reynolds number (0.01-100), wave amplitude (0-0.8), and wavelength (0.01-0.4) than the those attempted in previous studies reported in literature and some new results pertaining to the distribution of velocity, pressure, wall shear stress for different peristaltic flow conditions characterizing flow at moderately higher Reynolds number have been obtained. The effect of the wave amplitude, wavelength, and Reynolds number on the "flow trapping" mechanism induced by peristalsis has also been investigated here for higher ranges of values of the parameters characterizing peristalsis.

  15. A modeling and vibration analysis of a piezoelectric micro-pump diaphragm

    Science.gov (United States)

    Kaviani, Samira; Bahrami, Mohsen; Esfahani, Amir Monemian; Parsi, Behzad

    2014-12-01

    The vibration analysis of a micro-pump diaphragm is presented. A piezoelectric micro-pump is studied. For this purpose, a dynamic model of the micro-pump is derived. The micro-pump diaphragm is modeled as circular double membranes, a piezoelectric one as actuator and a silicon one for representing the membrane for pumping action. The damping effect of the fluid is introduced into the equations. Vibration analysis is established by explicitly solving the dynamic model. The natural frequencies and mode shapes are calculated. The orthogonality conditions of the system are discussed. To verify the results, the finite-element micro-pump model is developed in ANSYS software package. The results show that the two methods are well comparable.

  16. Pneumatically Actuated Miniature Peristaltic Vacuum Pumps

    Science.gov (United States)

    Feldman, Sabrina; Feldman, Jason; Svehla, Danielle

    2003-01-01

    Pneumatically actuated miniature peristaltic vacuum pumps have been proposed for incorporation into advanced miniature versions of scientific instruments that depend on vacuum for proper operation. These pumps are expected to be capable of reaching vacuum-side pressures in the torr to millitorr range (from .133 down to .0.13 Pa). Vacuum pumps that operate in this range are often denoted roughing pumps. In comparison with previously available roughing pumps, these pumps are expected to be an order of magnitude less massive and less power-hungry. In addition, they would be extremely robust, and would operate with little or no maintenance and without need for oil or other lubricants. Portable mass spectrometers are typical examples of instruments that could incorporate the proposed pumps. In addition, the proposed pumps could be used as roughing pumps in general laboratory applications in which low pumping rates could be tolerated. The proposed pumps could be designed and fabricated in conventionally machined and micromachined versions. A typical micromachined version (see figure) would include a rigid glass, metal, or plastic substrate and two layers of silicone rubber. The bottom silicone layer would contain shallow pump channels covered by silicone arches that could be pushed down pneumatically to block the channels. The bottom silicone layer would be covered with a thin layer of material with very low gas permeability, and would be bonded to the substrate everywhere except in the channel areas. The top silicone layer would be attached to the bottom silicone layer and would contain pneumatic- actuation channels that would lie crosswise to the pump channels. This version is said to be micromachined because the two silicone layers containing the channels would be fabricated by casting silicone rubber on micromachined silicon molds. The pneumatic-actuation channels would be alternately connected to a compressed gas and (depending on pump design) either to atmospheric

  17. Magnetic cantilever actuator with sharpened magnetic thin film ellipses

    Science.gov (United States)

    Huang, Chen-Yu; Ger, Tzong-Rong; Lai, Mei-Feng; Chen, We-Yun; Huang, Hao-Ting; Chen, Jiann-Yeu; Wang, Pei-Jen; Wei, Zung-Hang

    2015-05-01

    A SiO2 cantilever covered by elliptical magnetic thin films was designed as an actuator. Under magnetic field, the elliptical magnetic film with sharp ends would exhibit single-domain structures and generate torque to push or pull the two arms of the cantilever. The cantilever could then stretch or compress and the displacement could be controlled by adjusting the magnitude and direction of the external magnetic field. The combination between micromagnetism of patterned films and actuator was successfully demonstrated. The magnetic actuator can be applied for future application in the biological field and would be valuable for microelectromechanical systems (MEMS).

  18. Vibration analysis of magnetostrictive thin-film composite cantilever actuator

    Science.gov (United States)

    Xu, Yan; Shang, Xinchun

    2016-09-01

    The transverse vibration of a composed cantilever beam with magnetostrictive layer is analyzed, which is employed to simulate dynamic response of an actuator. The high-order shear deformation theory of beam and the coupling magnetoelastic constitutive relationship are introduced to construct the governing equations, all interface conditions between magnetostrictive film and elastic substrate as well as the free stress condition on the top and bottom surfaces of the beam can be satisfied. In order to demonstrate validity of the presented mathematical modeling, the verification examples are also given. Furthermore, the effect of geometry and material parameters on dynamic characteristics of magnetostrictive cantilever beam, such as the nature frequency and amplitude, is discussed. Moreover, through computing the magneto-mechanical coupling factor of the beam structure, the variation tendency curves of the factor along with different parameters and frequencies of magnetostrictive cantilever beam actuator have been presented. These numerical results should be useful for the design of beam-type with magnetostrictive thin-film actuators.

  19. DESIGN AND OPTIMIZATION OF VALVELESS MICROPUMPS BY USING GENETIC ALGORITHMS APPROACH

    Directory of Open Access Journals (Sweden)

    AIDA F. M. SHUKUR

    2015-10-01

    Full Text Available This paper presents a design optimization of valveless micropump using Genetic Algorithms (GA. The micropump is designed with a diaphragm, pumping chamber and diffuser/nozzle element functions as inlet and outlet of micropump with outer dimension of (5×1.75×5 mm3. The main objectives of this research are to determine the optimum pressure to be applied at micropump’s diaphragm and to find the optimum coupling parameters of the micropump to achieve high flow rate with low power consumption. In order to determine the micropump design performance, the total deformation, strain energy density, equivalent stress for diaphragm, velocity and net flow rate of micropump are investigated. An optimal resonant frequency range for the diaphragm of valveless micropump is obtained through the result assessment. With the development of GA-ANSYS model, a maximum total displacement of diaphragm, 5.3635 µm, with 12 kPa actuation pressure and optimum net flowrate of 7.467 mL/min are achieved.

  20. Effects of Magnetic Field and an Endoscope on Peristaltic Motion

    Directory of Open Access Journals (Sweden)

    V. P. Rathod

    2011-01-01

    Full Text Available The Problem of peristaltic transport of a magnetic fluid with variable viscosity through the gap between coaxial tubes where the outer tube is nonuniform with sinusoidal wave traveling down its wall and the inner tube is rigid. The relation between the pressure gradient and friction force on the inner and outer tubes is obtained in terms of magnetic and viscosity parameter. The numerical solutions of pressure gradient, outer friction and inner friction force, and flow rate are shown graphically.

  1. Peristaltic particle transport using the Lattice Boltzmann method

    Energy Technology Data Exchange (ETDEWEB)

    Connington, Kevin William [Los Alamos National Laboratory; Kang, Qinjun [Los Alamos National Laboratory; Viswanathan, Hari S [Los Alamos National Laboratory; Abdel-fattah, Amr [Los Alamos National Laboratory; Chen, Shiyi [JOHNS HOPKINS UNIV.

    2009-01-01

    Peristaltic transport refers to a class of internal fluid flows where the periodic deformation of flexible containing walls elicits a non-negligible fluid motion. It is a mechanism used to transport fluid and immersed solid particles in a tube or channel when it is ineffective or impossible to impose a favorable pressure gradient or desirous to avoid contact between the transported mixture and mechanical moving parts. Peristaltic transport occurs in many physiological situations and has myriad industrial applications. We focus our study on the peristaltic transport of a macroscopic particle in a two-dimensional channel using the lattice Boltzmann method. We systematically investigate the effect of variation of the relevant dimensionless parameters of the system on the particle transport. We find, among other results, a case where an increase in Reynolds number can actually lead to a slight increase in particle transport, and a case where, as the wall deformation increases, the motion of the particle becomes non-negative only. We examine the particle behavior when the system exhibits the peculiar phenomenon of fluid trapping. Under these circumstances, the particle may itself become trapped where it is subsequently transported at the wave speed, which is the maximum possible transport in the absence of a favorable pressure gradient. Finally, we analyze how the particle presence affects stress, pressure, and dissipation in the fluid in hopes of determining preferred working conditions for peristaltic transport of shear-sensitive particles. We find that the levels of shear stress are most hazardous near the throat of the channel. We advise that shear-sensitive particles should be transported under conditions where trapping occurs as the particle is typically situated in a region of innocuous shear stress levels.

  2. Augmentation of peristaltic microflows through electro-osmotic mechanisms

    International Nuclear Information System (INIS)

    The present work aims to theoretically establish that the employment of an axial electric field can substantially augment the rate of microfluidic transport occurring in peristaltic microtubes. For theoretical analysis, shape evolution of the tube is taken to be arbitrary, except for the fact that the characteristic wavelength is assumed to be significantly greater than the average radius of cross section. First, expressions for the velocity profile within the tube are derived and are subsequently utilized to obtain variations in the net flow rate across the same, as a function of the pertinent system parameters. Subsequently, the modes of interaction between the electro-osmotic and peristaltic mechanisms are established through the variations in the time-averaged flow rates for zero pressure rise and the pressure rise for zero time-averaged flow rates, as expressed in terms of the occlusion number, characteristic electro-osmotic velocity and the peristaltic wave speed. From the simulation predictions, it is suggested that a judicious combination of peristalsis and an axial electrokinetic body force can drastically enhance the time-averaged flow rate, provided that the occlusion number is relatively small

  3. Metal additive manufacturing of a high-pressure micro-pump

    OpenAIRE

    Wits, Wessel W.; Weitkamp, Sander J.; Es, van, J.M.

    2013-01-01

    For the thermal control of future space applications pumped two-phase loops are an essential part to handle the increasing thermal power densities. This study investigates the design of a reliable, leak tight, low-weight and high-pressure micro-pump for small satellite applications. The developed micro-pump uses a piezoelectric disk to create a pressure head and propel the working fluid. The micro-pumps are produced from Titanium alloy (Ti6Al4 V) using Selective Laser Melting (SLM) as a metal...

  4. A dynamic model of valveless micropumps with a fluid damping effect

    International Nuclear Information System (INIS)

    A simple fluid–diaphragm coupling model for studying the dynamic performance of valveless micropumps is presented. The model includes fluid inertia and a squeeze film effect by solving the coupling equation simultaneously with the Reynolds equation. The model is validated with a valveless diffuser micropump actuated by either a piezoelectric or electromagnetic diaphragm. The performance of the pump is considered for pumping liquid and air. The resonant frequency and dynamic performance of the micropumps obtained by the model are in good agreement with the experimental data. The model can predict well the damping behavior of the pump.

  5. A dynamic model of valveless micropumps with a fluid damping effect

    Science.gov (United States)

    Dinh, T. X.; Ogami, Y.

    2011-11-01

    A simple fluid-diaphragm coupling model for studying the dynamic performance of valveless micropumps is presented. The model includes fluid inertia and a squeeze film effect by solving the coupling equation simultaneously with the Reynolds equation. The model is validated with a valveless diffuser micropump actuated by either a piezoelectric or electromagnetic diaphragm. The performance of the pump is considered for pumping liquid and air. The resonant frequency and dynamic performance of the micropumps obtained by the model are in good agreement with the experimental data. The model can predict well the damping behavior of the pump.

  6. Design of T-Shaped Micropump Based on Induced Charge Electroosmotic

    OpenAIRE

    Bingying Sheng; Xiaojing Mi; Kai Zhang

    2013-01-01

    The fluid-driven efficiency of the micropump based on induced charge electroosmotic was studied by numerical simulation method. In this paper, we propose to make some improvement against the T-shaped piping design of micropump, and we embed a janus cylinder in the junction of the T-shaped pipe for the micropump design. We offer different voltage to the inlet of the pipe and carry out the numerical study of the fluid field induced by the cylinder, and the comparison of the velocity and flux of...

  7. A dynamic model for studying valveless electromagnetic micropumps

    International Nuclear Information System (INIS)

    In this paper, a fluid–diaphragm coupling model is proposed for studying the dynamic performance of a valveless micropump. In the model, fluid inertia is included and fluid pressure is obtained by solving the coupling equation simultaneously with Navier–Stokes equations through a transient dynamic mesh simulation. This process avoids the omission of the phase shift between the pressure force on the diaphragm and the flow rate of the pump. Furthermore, in this model, empirical parameters are almost eliminated. The model was applied to study the dynamic performance of a valveless electromagnetic micropump which uses a new working principle. The obtained results show that the flow rate attains its maximum value for a range of driving frequency. For instance, the flow rate reaches 1.6 ml min−1 for frequencies of 26–30 Hz when the electromagnetic force is 20 mN. The simulation results demonstrate that the flow rate of the proposed pump is much larger than that of the diffuser pump counterpart. A MEMS prototype has been fabricated and the attained backpressure validates the new pumping principle of the pump.

  8. A dynamic model for studying valveless electromagnetic micropumps

    Science.gov (United States)

    Dinh, T. X.; Le, N. T. M.; Dau, V. T.; Ogami, Y.

    2011-02-01

    In this paper, a fluid-diaphragm coupling model is proposed for studying the dynamic performance of a valveless micropump. In the model, fluid inertia is included and fluid pressure is obtained by solving the coupling equation simultaneously with Navier-Stokes equations through a transient dynamic mesh simulation. This process avoids the omission of the phase shift between the pressure force on the diaphragm and the flow rate of the pump. Furthermore, in this model, empirical parameters are almost eliminated. The model was applied to study the dynamic performance of a valveless electromagnetic micropump which uses a new working principle. The obtained results show that the flow rate attains its maximum value for a range of driving frequency. For instance, the flow rate reaches 1.6 ml min-1 for frequencies of 26-30 Hz when the electromagnetic force is 20 mN. The simulation results demonstrate that the flow rate of the proposed pump is much larger than that of the diffuser pump counterpart. A MEMS prototype has been fabricated and the attained backpressure validates the new pumping principle of the pump.

  9. Dual independent displacement-amplified micropumps with a single actuator

    Science.gov (United States)

    Tracey, M. C.; Johnston, I. D.; Davis, J. B.; Tan, C. K. L.

    2006-08-01

    We report a dual-micropump structure operated by a single actuator element. The constituent micropumps are a form of micro throttle pump (MTP) comprising a narrow flow channel incorporating two microthrottles. We term this a 'linear MTP' (LMTP). The LMTP's narrowness, in conjunction with an elastomeric substrate, allows multiple, independent, LMTPs to be actuated by a single piezoelectric actuator thereby suiting it to parallel microfluidic architectures. Furthermore, LMTP elements can be combined into parallel or series composites yielding increased maximum pumping rates or back pressures, respectively, when compared to a single LMTP element. The LMTP's flow-channel-like, linear pump chamber minimizes the development of recirculatory flows associated with circular pump chambers which, in part, determine their frequency response and hence maximum pumping rates. We have modelled, fabricated and evaluated a dual-LMTP. We report operation in three modes: as two distinct pumps, as a series composite pump, and as a parallel composite pump. Operating at about 1.6 kHz, with both pumps under identical load conditions, each pump yielded maximum pumping rates of about 750 µl min-1 and back pressures of 18 kPa, both with close matching. Configured as a series composite, a 35 kPa back pressure was achieved, and configured as a parallel composite, a maximum pumping rate of 1.4 ml min-1 resulted. Images of 5 µm polystyrene beads flowing within an LMTP confirm minimal recirculatory behaviour consistent with the LMTP's increased operating frequencies compared to circular pump chamber MTPs.

  10. Flow behavior of liquid-solid coupled system of piezoelectric micropump

    Institute of Scientific and Technical Information of China (English)

    Lijun LU; Jiankang WU

    2008-01-01

    This paper employs a shallow water model and the finite element method to approximate periodical flows of a micropump to a two-dimensional thickness-averaged flow. A liquid-solid coupled system equation of the micropump is presented. Through the mode analysis of the liquid-solid coupled system, the first-order natural frequency, diaphragm vibration shape and amplitude-frequency relationship are obtained. The vibration response of the diaphragm is calculated when an external electric field is applied. Based on the thickness-averaged flow equation, the periodical flow of the micropump is studied using the finite volume method to investigate the flow behavior and flow rate-frequency characteristics. Numerical results indicate that an optimal working frequency can be obtained, at which the flow rate of the micropump achieves the maximum when the external electric voltage is fixed.

  11. Performance of miniaturized direct methanol fuel cell (DMFC) devices using micropump for fuel delivery

    Science.gov (United States)

    Zhang, Tao; Wang, Qing-Ming

    A fuel cell is a device that can convert chemical energy into electricity directly. Among various types of fuel cells, both polymer electrolyte membrane fuel cells (PEMFCs) and direct methanol fuel cells (DMFCs) can work at low temperature (mini pumps, the size of the piezoelectric micropump is much smaller and the energy consumption is much lower. Thus, it is very viable and effective to use a piezoelectric valveless micropump for fuel delivery in miniaturized DMFC power systems.

  12. Two way fluid structure interaction analysis of a valveless micropump by CFD

    Science.gov (United States)

    Cǎlimǎnescu, Ioan; Dumitrache, Constantin L.; Grigorescu, Lucian

    2015-02-01

    In the microfluid control system, a valve-less micropump is a necessary component. It has the ability to pump a wide variety of fluids automatically and accurately on a micro scale. The dynamic characteristics of a valve-less micropump influence the performance of the microfluid control system. Consequently, it is of great importance to be able to accurately predict the dynamic characteristics of micropumps for appropriate design and usage of the microfluid control system. In this paper, we describe a corrugated diaphragm valveless micropump approached from the Computational Fluid Dynamics point of view in which the Fluid Structure Interaction is based on the Two Way principle, meaning that the diaphragm is moving and the fluid (water like fluid) is sucked from the inlet and pushed back to the outlet using the nozzle effect. The technical solution of micropumps without valves is a very clever idea to replace the custom valves with nozzles, with the same effect but virtually without any components beside the inlet and the outlet nozzles. The paperwork is demonstrating via a complex simulation involving the structural-fluid interaction the nozzle effects and the functioning of this kind of micropumps.

  13. Modeling and design of light powered biomimicry micropump utilizing transporter proteins

    Science.gov (United States)

    Liu, Jin; Sze, Tsun-Kay Jackie; Dutta, Prashanta

    2014-11-01

    The creation of compact micropumps to provide steady flow has been an on-going challenge in the field of microfluidics. We present a mathematical model for a micropump utilizing Bacteriorhodopsin and sugar transporter proteins. This micropump utilizes transporter proteins as method to drive fluid flow by converting light energy into chemical potential. The fluid flow through a microchannel is simulated using the Nernst-Planck, Navier-Stokes, and continuity equations. Numerical results show that the micropump is capable of generating usable pressure. Designing parameters influencing the performance of the micropump are investigated including membrane fraction, lipid proton permeability, illumination, and channel height. The results show that there is a substantial membrane fraction region at which fluid flow is maximized. The use of lipids with low membrane proton permeability allows illumination to be used as a method to turn the pump on and off. This capability allows the micropump to be activated and shut off remotely without bulky support equipment. This modeling work provides new insights on mechanisms potentially useful for fluidic pumping in self-sustained bio-mimic microfluidic pumps. This work is supported in part by the National Science Fundation Grant CBET-1250107.

  14. Actuation method and apparatus, micropump, and PCR enhancement method

    Energy Technology Data Exchange (ETDEWEB)

    Ullakko, Kari; Mullner, Peter; Hampikian, Greg; Smith, Aaron

    2015-07-28

    An actuation apparatus includes at least one magnetic shape memory (MSM) element containing a material configured to expand and/or contract in response to exposure to a magnetic field. Among other things, the MSM element may be configured to pump fluid through a micropump by expanding and/or contracting in response to the magnetic field. The magnetic field may rotate about an axis of rotation and exhibit a distribution having a component substantially perpendicular to the axis of rotation. Further, the magnetic field distribution may include at least two components substantially orthogonal to one another lying in one or more planes perpendicular to the axis of rotation. The at least one MSM element may contain nickel, manganese, and gallium. A polymerase chain reaction (PCR) may be enhanced by contacting a PCR reagent and DNA material with the MSM element.

  15. Backward flow in a surface tension driven micropump

    International Nuclear Information System (INIS)

    A surface tension driven micropump harnessing the pressure difference generated by drops of different curvature radii proves to be a simple and attractive passive method to drive fluid flow in microdevices. Here we observed the appearance of backward flow when the initial sizes of the droplets at the inlet and outlet ports are similar. To explain this phenomenon several hypotheses have been investigated. Consideration of the inertia of the fluid in the channel revealed that it alone is insufficient to explain the observed backward flow. We discovered that rotational flow inside the outlet droplet could be a source of inertia, explaining the generation of the backward flow. In addition, we have experimentally determined that the ratio of the volumes of the initial outlet drop and inlet drop correlates with the occurrence of the backward flow. (note)

  16. In vivo organ specific drug delivery with implantable peristaltic pumps.

    Science.gov (United States)

    Speed, Joshua S; Hyndman, Kelly A

    2016-01-01

    Classic methods for delivery of agents to specific organs are technically challenging and causes superfluous stress. The current study describes a method using programmable, implantable peristaltic pumps to chronically deliver drugs in vivo, while allowing animals to remain undisturbed for accurate physiological measurements. In this study, two protocols were used to demonstrate accurate drug delivery to the renal medulla. First, the vasopressin receptor-2 agonist, dDAVP, was delivered to the renal medulla resulting in a significant increase in water retention, urine osmolality and aquaporin-2 expression and phosphorylation. Second, in a separate group of rats, the histone deacetylase (HDAC) inhibitor, MS275, was delivered to the renal medulla. HDAC inhibition resulted in a significant increase in histone H3-acetylation, the hallmark for histone deacetylase inhibition. However, this was confined to the medulla, as the histone H3-acetylation was similar in the cortex of vehicle and MS275 infused rats, suggesting targeted drug delivery without systemic spillover. Thus, implantable, peristaltic pumps provide a number of benefits compared to externalized chronic catheters and confer specific delivery to target organs. PMID:27185292

  17. Design, fabrication, and characterization of a valveless magnetic travelling-wave micropump

    International Nuclear Information System (INIS)

    In this paper, we propose a valveless magnetic micropump for lab-on-a-chip and microfluidic applications. The micropump, based on polydimethylsiloxane (PDMS) and polymethylmethacrylate (PMMA), consists primarily of a saw-toothed microchannel, two substrates, and two integrated NdFeB permanent magnetic arrays. The travelling wave beneath the top wall of the elastic microchannel can be induced by the proper magnetic pole orientation arrangement of these magnetic arrays, and the liquid particles are then transported along with the travelling wave in the microchannel. Appropriate geometry of the saw-toothed microchannel was also studied for optimizing the performance of the micropump. Experimental characterization of the micropump has been performed in terms of the frequency response of the flow rate and backpressure. The results demonstrate that this micropump is capable of reliably generating a maximum flow rate of 342.4 μL min−1 and operating against a high backpressure of 1.67 kPa. (paper)

  18. An Electromagnetically-Actuated All-PDMS Valveless Micropump for Drug Delivery

    Directory of Open Access Journals (Sweden)

    Farid Amirouche

    2011-07-01

    Full Text Available This paper presents the fabrication process of a single-chamber planar valveless micropump driven by an external electromagnetic actuator. This micropump features a pair of micro diffuser and nozzle elements used to rectify the fluid flow, and an elastic magnetic membrane used to regulate the pressure in the enclosed fluid chamber. Polydimethylsiloxane (PDMS is used as the main construction material of this proposed micropump, including the structural substrate and the planar actuation membrane embedded with a thin micro magnet. Both the Finite Element Method and experimental analysis are used to assess the PDMS-membrane actuation under the applied electromagnetic forces and characterize the pump performance at variable working conditions. The resonant frequency of this micropump is identified experimentally and de-ionized (DI water is loaded to account for the coupling effects of the working fluid. The experimental data was used to demonstrate the reliability of flow rates and how it can be controlled by consistently adjusting the driving frequencies and currents. The proposed micropump is capable of delivering a maximum flow rate of 319.6 μL/min and a maximum hydrostatic backpressure of 950 Pa (9.5 cm H2O. The planar design feature of the pump allows for potential integration of the pump with other PDMS-based microfluidic systems for biomedical applications.

  19. Design, fabrication, and characterization of a valveless magnetic travelling-wave micropump

    Science.gov (United States)

    Yu, Huawei; Ye, Weixiang; Zhang, Wei; Yue, Zhao; Liu, Guohua

    2015-06-01

    In this paper, we propose a valveless magnetic micropump for lab-on-a-chip and microfluidic applications. The micropump, based on polydimethylsiloxane (PDMS) and polymethylmethacrylate (PMMA), consists primarily of a saw-toothed microchannel, two substrates, and two integrated NdFeB permanent magnetic arrays. The travelling wave beneath the top wall of the elastic microchannel can be induced by the proper magnetic pole orientation arrangement of these magnetic arrays, and the liquid particles are then transported along with the travelling wave in the microchannel. Appropriate geometry of the saw-toothed microchannel was also studied for optimizing the performance of the micropump. Experimental characterization of the micropump has been performed in terms of the frequency response of the flow rate and backpressure. The results demonstrate that this micropump is capable of reliably generating a maximum flow rate of 342.4 μL min-1 and operating against a high backpressure of 1.67 kPa.

  20. Peristaltic Transport of a Couple Stress Fluid : Some Physiological Applications

    CERN Document Server

    Maiti, S

    2010-01-01

    The present paper deals with a theoretical investigation of the peristaltic transport of a couple stress fluid in a porous channel. The study is motivated towards the physiological flow of blood in the micro-circulatory system, by taking account of the particle size effect. The velocity, pressure gradient, stream function and frictional force of blood are investigated, when the Reynolds number is small and the wavelength is large, by using appropriate analytical and numerical methods. Effects of different physical parameters reflecting porosity, Darcy number, couple stress parameter as well as amplitude ratio on velocity profiles, pumping action and frictional force, streamlines pattern and trapping of blood are studied with particular emphasis. The computational results are presented in graphical form. The results are found to be in good agreement with those of Shapiro et. al \\cite{r25} that was carried out for a non-porous channel in the absence of couple stress effect. The present study puts forward an imp...

  1. Fabrication and study of AC electro-osmotic micropumps

    Science.gov (United States)

    Guo, Xin

    In this thesis, microelectrode arrays of micropumps have been designed, fabricated and characterized for transporting microfluid by AC electro-osmosis (ACEO). In particular, the 3D stepped electrode design which shows superior performance to others in literature is adopted for making micropumps, and the performance of such devices has been studied and explored. A novel fabrication process has also been developed in the work, realizing 3D stepped electrodes on a flexible substrate, which is suitable for biomedical use, for example glaucoma implant. There are three major contributions to ACEO pumping in the work. First, a novel design of 3D "T-shaped" discrete electrode arrays was made using PolyMUMPsRTM process. The breakthrough of this work was discretizing the continuous 3D stepped electrodes which were commonly seen in the past research. The "T-shaped" electrodes did not only create ACEO flows on the top surfaces of electrodes but also along the side walls between separated electrodes. Secondly, four 3D stepped electrode arrays were designed, fabricated and tested. It was found from the experiment that PolyMUMPsRTM ACEO electrodes usually required a higher driving voltage than gold electrodes for operation. It was also noticed that a simulation based on the modified model taking into account the surface oxide of electrodes showed a better agreement with the experimental results. It thus demonstrated the possibility that the surface oxide of electrodes had impact on fluidic pumping. This methodology could also be applied to metal electrodes with a native oxide layer such as titanium and aluminum. Thirdly, a prototype of the ACEO pump with 3D stepped electrode arrays was first time realized on a flexible substrate using Kapton polyimide sheets and packaged with PDMS encapsulants. Comprehensive experimental testing was also conducted to evaluate the mechanical properties as well as the pumping performance. The experimental findings indicated that this fabrication

  2. Static characteristic analysis on a hydrodynamic bearing of a hydraulic suspended micropump

    International Nuclear Information System (INIS)

    A hydraulic suspended micropump was designed based on the conception of double suction impeller. To study the running performance of the micropump, three dimensional simulation of the static characteristic of the hydrodynamic bearing at rated condition was performed. Parameters such as the eccentricity and rotational speed, having effect on the bearing capacity, were analyzed. Results show that the eccentricity and rotational speed have a certain effect on the bearing capacity. The region of the maximum static pressure and the positive pressure changes as the eccentricity increases. The bearing capacity improves as the rotational speed increases. All the results can provide a academic basis for the improvement and application of a hydrodynamic bearing of a micropump

  3. Development of Stepper motor based Two DOF Robotic Arm Transferring Liquid using Peristaltic Pump

    OpenAIRE

    Padma Thiagarajan; Sudha Ramasamy; Karthikesh.R; Manikandan.P

    2013-01-01

    The aim of this work is to transfer liquid contents from one micro cell to another using two stepper motors and a peristaltic pump. There are two objectives here. One is to develop a low cost roboticarm using stepper motors. The second objective is the control and calibration of the peristaltic pump. All parts are controlled and operated by their respective microcontrollers. Fulfillment of both the objectives leads to an integrated system to transfer liquids from one cell to another. The end ...

  4. Peristaltic Flow of Phan-Thien-Tanner Fluid in an Asymmetric Channel with Porous Medium

    OpenAIRE

    Kuppalapalle Vajravelu; S.Sreenadh; Lakshminarayana, P; G. Sucharitha; Rashidi, M. M.

    2016-01-01

    This paper deals with peristaltic transport of Phan-Thien-Tanner fluid in an asymmetric channel induced by sinusoidal peristaltic waves traveling down the flexible walls of the channel. The flow is investigated in a wave frame of reference moving with the velocity of the waveby using the long wavelength and low Reynolds number approximations.The nonlinear governing equations are solved employing a perturbation method by choosing as the perturbation parameter. The expressions for velocity, s...

  5. A membrane-based serpentine-shape pneumatic micropump with pumping performance modulated by fluidic resistance

    International Nuclear Information System (INIS)

    This paper reports a new membrane-based pneumatic micropump with new serpentine-shape (S-shape) pneumatic channels intended for achieving high-throughput pumping in a microfluidic system at a relatively low pumping rate and a board flow rate range. The key feature of this design is the ability to modulate the pumping rates by fine-tuning the fluidic resistance of injected compressed air in the designed pneumatic microchannels and the chambers of the micropump. In the study, several S-shape pneumatic micropumps with various layouts were designed and fabricated based on thick-film photoresist lithography and polydimethylsiloxane (PDMS) replication processes. To investigate designs with a suitable pumping performance, S-shape pneumatic micropumps with varied lengths (1000, 5000 and 10 000 µm), varied widths (20, 40 and 200 µm) of the pneumatic microchannel bridging two rectangular pneumatic chambers, and different numbers of pneumatic channel bends (two and four U-shape bends) were designed and evaluated experimentally by using high-speed CCD-coupled microscopic observation of the movement of PDMS membrane pulsation and pumping rate measurements. The results revealed that under the experimental conditions studied, the layout of the S-shape pneumatic micropump with three rectangular pneumatic chambers, 5000 µm long and 40 µm wide pneumatic microchannel and four U-shape bends in the pneumatic microchannel was found to be capable of providing a broader pumping rate range from 0 to 539 µl h−1 compared to the other designs. As a whole, the experimental results demonstrate the use of fluidic resistance of injected air in a pneumatic micropump with S-shape layout to control its pumping performance, which largely expands the flexibility of its pumping application in a microfluidic system

  6. Simulations of Micropumps Based on Tilted Flexible Fibers

    Science.gov (United States)

    Hancock, Matthew; Elabbasi, Nagi; Demirel, Melik

    2015-11-01

    Pumping liquids at low Reynolds numbers is challenging because of the principle of reversibility. We report here a class of microfluidic pump designs based on tilted flexible structures that combines the concepts of cilia (flexible elastic elements) and rectifiers (e.g., Tesla valves, check valves). We demonstrate proof-of-concept with 2D and 3D fluid-structure interaction (FSI) simulations in COMSOL Multiphysics®of micropumps consisting of a source for oscillatory fluidic motion, e.g. a piston, and a channel lined with tilted flexible rods or sheets to provide rectification. When flow is against the rod tilt direction, the rods bend backward, narrowing the channel and increasing flow resistance; when flow is in the direction of rod tilt, the rods bend forward, widening the channel and decreasing flow resistance. The 2D and 3D simulations involve moving meshes whose quality is maintained by prescribing the mesh displacement on guide surfaces positioned on either side of each flexible structure. The prescribed displacement depends on structure bending and maintains mesh quality even for large deformations. Simulations demonstrate effective pumping even at Reynolds numbers as low as 0.001. Because rod rigidity may be specified independently of Reynolds number, in principle, rod rigidity may be reduced to enable pumping at arbitrarily low Reynolds numbers.

  7. Design, modeling and fabrication of a constant flow pneumatic micropump

    Science.gov (United States)

    Inman, Walker; Domansky, Karel; Serdy, James; Owens, Bryan; Trumper, David; Griffith, Linda G.

    2007-05-01

    This paper characterizes a bi-directional pneumatic diaphragm micropump and presents a model for performance of an integrated fluidic capacitor. The fluidic capacitor is used to convert pulsatile flow into a nearly continuous flow stream. The pump was fabricated in acrylic using a CNC mill. The stroke volume of the pump is ~1 µL. The pump is self-priming, bubble tolerant and insensitive to changes in head pressure and pneumatic pressure within its operating range. The pump achieves a maximum flow rate of 5 mL min-1 against zero head pressure. With pneumatic pressure set to 40 kPa, the pump can provide flow at 2.6 mL min-1 against a head pressure of 25 kPa. A nonlinear model for the capacitor was developed and compared with experimental results. The ratio of the time constant of the capacitor to the cycle time of the pump is shown to be an accurate indicator of capacitor performance and a useful design tool.

  8. Treating gastrointestinal cancer by intervention, intraperitoneal hyperthermic perfusion chemotherapy, intravenous micro-pump chemotherapy

    International Nuclear Information System (INIS)

    157 cases of gastrointestinal cancer patients after resection were randomly divided into treated group and control group. The treated group (intraperitoneal hyperthermic perfusion chemotherapy combined with postoperative continuous intraarterial infusion and intravenous micro-pump chemotherapy) consisted of 72 cases, the control group (Intravenous chemotherapy), 85 cases. The peritoneal and hepatic metastasis rates and 3 a survival rate were studied. The intraperitoneal hyperthermic perfusion chemotherapy combined with the postoperative continuous intraarterial infusion and intravenous micro-pump chemotherapy is an effective way to control the recurrence on the peritoneal and hepatic metastasis of advanced gastrointestinal neoplasms after operation. (authors)

  9. Design of IPMC actuator-driven valve-less micropump and its flow rate estimation at low Reynolds numbers

    Science.gov (United States)

    Lee, Sangki; Kim, Kwang J.

    2006-08-01

    This paper presents the design and flow rate predictions of an IPMC (ionic polymer-metal composite) actuator-driven valve-less micropump. It should be noted that IPMC is a promising material candidate for micropump applications since it can be operated with low input voltages and can produce large stroke volumes, while having controllable flow rates. The micropump manufacturing process with IPMC is also convenient; it is anticipated that the manufacturing cost of the IPMC micropump is competitive with other technologies. In order to design an effective IPMC diaphragm that functions as an actuating motor for a micropump, a finite element analysis (FEA) was utilized to optimize the electrode shape of the IPMC diaphragm and estimate its stroke volumes. In addition, the effect of the pump chamber pressure on the stroke volume was numerically investigated. Appropriate inlet and outlet nozzle/diffuser elements were also studied for the valve-less micropump. Based on the selected geometry of nozzle/diffuser elements and the estimated stroke volume of the IPMC diaphragm, the flow rate of the micropump was estimated at a low Reynolds number of about 50.

  10. A self-priming, high performance, check valve diaphragm micropump made from SOI wafers

    Science.gov (United States)

    Kang, Jianke; Mantese, Joseph V.; Auner, Gregory W.

    2008-12-01

    In this paper, we describe a self-priming high performance piezoelectrically actuated check valve diaphragm micropump. The micropump was fabricated from three wafers: two silicon-on-insulator (SOI) wafers and one silicon wafer. A process named 'SOI/SOI wafer bonding and etching back followed by a second wafer bonding' was developed in order to make the core components of this device which included an inlet check valve, an outlet check valve, a diaphragm and a chamber. The movable structures of this device, i.e. the check valves and the diaphragm, were fabricated from the device layers of the two bonded SOI wafers. Taking advantages of SOI wafer technology and etch-stop layers, the vertical parameters of the movable structures were precisely controlled in fabrication. The micropump was self-priming without any pre-filling process. The pumping rate of the micropump was linearly adjustable from 0 to 650l µm min-1 by adjusting frequency. The maximum pumping rate was 860 µl min-1 and the maximum pumping pressure was approximately 10.5 psi. The power consumption of the device was less than 1.2 mW.

  11. A self-priming, high performance, check valve diaphragm micropump made from SOI wafers

    International Nuclear Information System (INIS)

    In this paper, we describe a self-priming high performance piezoelectrically actuated check valve diaphragm micropump. The micropump was fabricated from three wafers: two silicon-on-insulator (SOI) wafers and one silicon wafer. A process named 'SOI/SOI wafer bonding and etching back followed by a second wafer bonding' was developed in order to make the core components of this device which included an inlet check valve, an outlet check valve, a diaphragm and a chamber. The movable structures of this device, i.e. the check valves and the diaphragm, were fabricated from the device layers of the two bonded SOI wafers. Taking advantages of SOI wafer technology and etch-stop layers, the vertical parameters of the movable structures were precisely controlled in fabrication. The micropump was self-priming without any pre-filling process. The pumping rate of the micropump was linearly adjustable from 0 to 650l µm min−1 by adjusting frequency. The maximum pumping rate was 860 µl min−1 and the maximum pumping pressure was approximately 10.5 psi. The power consumption of the device was less than 1.2 mW

  12. Characteristic of TiNi(Cu) shape memory thin film based on micropump

    Science.gov (United States)

    Zhang, Huijun; Qiu, Chengjun

    2009-07-01

    Shape memory thin films offer a unique combination of novel properties and have the potential to become a primary actuating mechanism for micropumps. In this study, a micropump driven by TiNiCu shape memory thin film is designed and fabricated. The micropump is composed of a TiNiCu/Si bimorph driving membrane, a pump chamber and two inlet and outlet check valves. The property of TiNiCu films and driving capacity of TiNiCu/Si bimorph driving membrane are investigated. By using the recoverable force of TiNiCu thin film and biasing force of silicon membrane, the actuation diaphragm realizes reciprocating motion effectively. Experimental results show that the film surface appears a smooth and featureless morphology without any cracks, and the hysteresis width ΔT of TiNiCu film is about 2-3°C, the micropump driving by TiNiCu film has good performance, such as high pumping yield, high working frequency, stable driving capacity, and long fatigue life time.

  13. Metal additive manufacturing of a high-pressure micro-pump

    NARCIS (Netherlands)

    Wits, Wessel W.; Weitkamp, Sander J.; Es, van J.

    2013-01-01

    For the thermal control of future space applications pumped two-phase loops are an essential part to handle the increasing thermal power densities. This study investigates the design of a reliable, leak tight, low-weight and high-pressure micro-pump for small satellite applications. The developed mi

  14. Peristaltic motion of third grade fluid in curved channel

    Institute of Scientific and Technical Information of China (English)

    S.HINA; M.MUSTAFA; T.HAYAT; F.E.ALSAADI

    2014-01-01

    Analysis is performed to study the slip effects on the peristaltic flow of non-Newtonian fluid in a curved channel with wall properties. The resulting nonlinear partial differential equations are transformed to a single ordinary differential equation in a stream function by using the assumptions of long wavelength and low Reynolds number. This differential equation is solved numerically by employing the built-in routine for solving nonlinear boundary value problems (BVPs) through the software Mathematica. In addition, the analytic solutions for small Deborah number are computed with a regular perturbation technique. It is noticed that the symmetry of bolus is destroyed in a curved channel. An intensification in the slip effect results in a larger magnitude of axial velocity. Further, the size and circulation of the trapped boluses increase with an increase in the slip parameter. Different from the case of planar channel, the axial velocity profiles are tilted towards the lower part of the channel. A comparative study between analytic and numerical solutions shows excellent agreement.

  15. Peristaltic Pumping of Blood in micro-vessels of Non-uniform Cross-section

    CERN Document Server

    Misra, J C

    2010-01-01

    The paper is devoted to a study of the peristaltic motion of blood in the micro-circulatory system. The vessel is considered of non-uniform cross-section. The progressive peristaltic waves are taken to be of sinusoidal nature. The Reynolds number is considered to be small. Blood is considered to be a Herschel-Bulkley fluid. Of particular concern here is to investigate the effects of amplitude ratio, mean pressure gradient, yield stress and the power law index on the velocity distribution, streamline pattern and wall shear stress. Basing upon the study, extensive numerical calculations has been made. The study reveals that peristaltic pumping as well as velocity and wall shear stress are appreciably affected due to the non-uniform geometry of blood vessels. They are also highly sensitive to the magnitude of the amplitude of the amplitude ratio and the value of the fluid index.

  16. Peristaltic transport of Carreau-Yasuda fluid in a curved channel with slip effects.

    Directory of Open Access Journals (Sweden)

    Tasawar Hayat

    Full Text Available The wide occurrence of peristaltic pumping should not be surprising at all since it results physiologically from neuro-muscular properties of any tubular smooth muscle. Of special concern here is to predict the rheological effects on the peristaltic motion in a curved channel. Attention is focused to develop and simulate a nonlinear mathematical model for Carreau-Yasuda fluid. The progressive wave front of peristaltic flow is taken sinusoidal (expansion/contraction type. The governing problem is challenge since it has nonlinear differential equation and nonlinear boundary conditions even in the long wavelength and low Reynolds number regime. Numerical solutions for various flow quantities of interest are presented. Comparison for different flow situations is also made. Results of physical quantities are interpreted with particular emphasis to rheological characteristics.

  17. Analysis of Entropy Generation in the Flow of Peristaltic Nanofluids in Channels With Compliant Walls

    Directory of Open Access Journals (Sweden)

    Munawwar Ali Abbas

    2016-03-01

    Full Text Available Entropy generation during peristaltic flow of nanofluids in a non-uniform two dimensional channel with compliant walls has been studied. The mathematical modelling of the governing flow problem is obtained under the approximation of long wavelength and zero Reynolds number (creeping flow regime. The resulting non-linear partial differential equations are solved with the help of a perturbation method. The analytic and numerical results of different parameters are demonstrated mathematically and graphically. The present analysis provides a theoretical model to estimate the characteristics of several Newtonian and non-Newtonian fluid flows, such as peristaltic transport of blood.

  18. Flow Rate Driven by Peristaltic Movement in Plasmodial Tube of Physarum Polycephalum

    Science.gov (United States)

    Yamada, Hiroyasu; Nakagaki, Toshiyuki

    2008-07-01

    We report a theoretical analysis of protoplasmic streaming driven by peristaltic movement in an elastic tube of an amoeba-like organism. The Plasmodium of Physarum polycephalum, a true slime mold, is a large amoeboid organism that adopts a sheet-like form with a tubular network. The network extends throughout the Plasmodium and enables the transport and circulation of chemical signals and nutrients. This tubular flow is driven by periodically propagating waves of active contraction of the tube cortex, a process known as peristaltic movement. We derive the relationship between the phase velocity of the contraction wave and the flow rate, and we discuss the physiological implications of this relationship.

  19. Analysis on and Optimization of a Circular Piezoelectric Composite Laminate for a Micro-Pump Driver

    International Nuclear Information System (INIS)

    Among the various micro-pump actuation devices, piezoelectric composite laminate actuation has become an effective method. Due to lacking of analysis treatments, the design of this type micro-pump is in a great limitation. In this paper, an electromechanical-coupled mechanics model is established for the circle-flake micro-actuator. A kind of analysis and design method is presented that piezoelectric plate's radial strain induced by inverse piezoelectric effect is equivalently substituted with transverse stress on piezoelectric composite laminates. It is pointed out that the equivalent transverse load depends on the edge electric field distribution of parallel plate capacitor. The question has been solved that where the neutral plane in the piezoelectric composite laminates lies. Finally, an optimization design is developed on the radius ratio of piezoelectric-to-silicon plate radius by utilizing of FEA modeling

  20. Magnetohydrodynamic flow of generalized Maxwell fluids in a rectangular micropump under an AC electric field

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Guangpu [School of Mathematical Science, Inner Mongolia University, Hohhot, Inner Mongolia 010021 (China); Jian, Yongjun, E-mail: jianyj@imu.edu.cn [School of Mathematical Science, Inner Mongolia University, Hohhot, Inner Mongolia 010021 (China); Chang, Long [School of Mathematics and Statistics, Inner Mongolia University of Finance and Economics, Hohhot, Inner Mongolia 010051 (China); Buren, Mandula [School of Mathematical Science, Inner Mongolia University, Hohhot, Inner Mongolia 010021 (China)

    2015-08-01

    By using the method of separation of variables, an analytical solution for the magnetohydrodynamic (MHD) flow of the generalized Maxwell fluids under AC electric field through a two-dimensional rectangular micropump is reduced. By the numerical computation, the variations of velocity profiles with the electrical oscillating Reynolds number Re, the Hartmann number Ha, the dimensionless relaxation time De are studied graphically. Further, the comparison with available experimental data and relevant researches is presented. - Highlights: • MHD flow of the generalized Maxwell fluids under AC electric field is analyzed. • The MHD flow is confined to a two-dimensional rectangular micropump. • Analytical solution is obtained by using the method of separation of variables. • The influences of related parameters on the MHD velocity are discussed.

  1. Magnetohydrodynamic flow of generalized Maxwell fluids in a rectangular micropump under an AC electric field

    International Nuclear Information System (INIS)

    By using the method of separation of variables, an analytical solution for the magnetohydrodynamic (MHD) flow of the generalized Maxwell fluids under AC electric field through a two-dimensional rectangular micropump is reduced. By the numerical computation, the variations of velocity profiles with the electrical oscillating Reynolds number Re, the Hartmann number Ha, the dimensionless relaxation time De are studied graphically. Further, the comparison with available experimental data and relevant researches is presented. - Highlights: • MHD flow of the generalized Maxwell fluids under AC electric field is analyzed. • The MHD flow is confined to a two-dimensional rectangular micropump. • Analytical solution is obtained by using the method of separation of variables. • The influences of related parameters on the MHD velocity are discussed

  2. A novel micropump with fixed-geometry valves and low leakage flow

    Science.gov (United States)

    Hwang, Il-Han; An, Jae-Yong; Ko, Kwang-Hee; Shin, Sang-Mo; Lee, Jong-Hyun

    2007-08-01

    A novel micropump with fixed-geometry valves was designed and tested with a leakage barrier to reduce leakage flow. Conventional micropumps with fixed-geometry valves have achieved net positive fluid flow from different fluid resistances in diffuser/nozzle channels. However, those micropumps are susceptible to leakage flow even at low pressure differences between the inlet and the outlet because the channels remain normally open state when the pumps are not in operation. Therefore, a leakage barrier in the chamber was designed to reduce leakage flow without interfering with the net positive fluid flow of the diffuser/nozzle channels. The diffuser/nozzle channels, the chamber and the leakage barrier were fabricated on the silicon substrate by KOH etching and the silicon substrate was anodically bonded with a Pyrex glass plate. A PZT disk was bonded on the glass plate by epoxy and was actuated to oscillate the glass diaphragm for flow generation. When the micropump is not operating, the leakage barrier removes most of the gap between the glass plate and the bottom of the chamber. It was experimentally confirmed that the leakage barrier reduced the leakage flow by 96% compared to the case of no leakage barrier at a pressure difference of -400 Pa. Moreover, by applying the holding dc voltage to the PZT disk, a smaller gap can be obtained reducing the leakage flow further down to 0.043 µL min-1 at a holding dc voltage of 100 V. The maximum flow rate was 3.9 µL min-1 at a peak-to-peak driving voltage of 150 V at 20 Hz with a maximum back pressure of around 800 Pa. The approximate device size was 18 × 25 mm2.

  3. A novel fabrication process to release a valveless micropump on a flexible substrate

    OpenAIRE

    Wei, Yang; Torah, R.N.; Yang, Kai; Beeby, S. P.; Tudor, John

    2013-01-01

    This paper reports, for the first time, the design, fabrication and testing of a valveless micropump, entirely screen printed onto a flexible polyimide (Kapton) substrate by using sacrificial, polymer-structural and piezoelectric layers. The sacrificial layer, used to achieve a pump chamber and inlet/outlet channels, is thermally removed, analogous to a standard MEMS sacrificial process. Applying a sinusoidal AC voltage to the piezoelectric layer drives a flexible membrane which pumps liquid...

  4. The self-generated peristaltic motion of cascaded pneumatic actuators for micro pumps

    International Nuclear Information System (INIS)

    This paper presents a new actuation mechanism for the self-generated peristaltic motion of cascaded actuators and its application to micro pumps. The operational method is based on the fluidic circuit of an elastic tube. The elastic tube is modeled as a ladder network consisting of fluidic resistances in series and fluidic capacitances in parallel like multi-stage low-pass filters in an electrical circuit. All segments of the lumped model of the elastic tube have different dynamic characteristics because their time constants are different. In other words, all segments should be deformed sequentially like peristaltic motion. This phenomenon has good potential to cause peristaltic motion of the cascaded actuators in response to the application of single-phase pneumatic signals. Analogues between the electrical and fluidic circuits were applied to a pneumatic micro pump with a micro fluidic channel and three pneumatic actuators connecting a unique micro channel for supplying the compressed air. The polymeric micro pumps were fabricated with soft lithography using only polyimethylsiloxsane. The proposed working principle was verified through simulation of the static deformation of the cascaded actuator diaphragms and the actuator, as well as tested experimentally. The dual operational modes of the proposed device (i.e., rubber-seal valve and peristaltic pumping mode) were also verified and successfully demonstrated in a liquid pumping test of the single and double pumps

  5. Development of Stepper motor based Two DOF Robotic Arm Transferring Liquid using Peristaltic Pump

    Directory of Open Access Journals (Sweden)

    Padma Thiagarajan

    2013-02-01

    Full Text Available The aim of this work is to transfer liquid contents from one micro cell to another using two stepper motors and a peristaltic pump. There are two objectives here. One is to develop a low cost roboticarm using stepper motors. The second objective is the control and calibration of the peristaltic pump. All parts are controlled and operated by their respective microcontrollers. Fulfillment of both the objectives leads to an integrated system to transfer liquids from one cell to another. The end effecter of the robotic arm is connected to the peristaltic pump. The pump has two pipes connected to it. Through one pipe it takes in the liquid and through the other pipe it delivers the liquid into the second cell. After transferring one sample of liquid, the arm moves to a cleaning module where the end effecter is cleaned to avoid cross contamination. The robotic arm is built using stepper motors and controlled using Atmega32 microcontroller whereas the peristaltic pump is controlled and calibrated using 8051 microcontroller. The pumping is done with the help of DC motors. As a result, the working of the robotic arm and theperistaltic pump is verified experimentally.

  6. The self-generated peristaltic motion of cascaded pneumatic actuators for micro pumps

    Science.gov (United States)

    Jeong, Ok Chan; Konishi, Satoshi

    2008-08-01

    This paper presents a new actuation mechanism for the self-generated peristaltic motion of cascaded actuators and its application to micro pumps. The operational method is based on the fluidic circuit of an elastic tube. The elastic tube is modeled as a ladder network consisting of fluidic resistances in series and fluidic capacitances in parallel like multi-stage low-pass filters in an electrical circuit. All segments of the lumped model of the elastic tube have different dynamic characteristics because their time constants are different. In other words, all segments should be deformed sequentially like peristaltic motion. This phenomenon has good potential to cause peristaltic motion of the cascaded actuators in response to the application of single-phase pneumatic signals. Analogues between the electrical and fluidic circuits were applied to a pneumatic micro pump with a micro fluidic channel and three pneumatic actuators connecting a unique micro channel for supplying the compressed air. The polymeric micro pumps were fabricated with soft lithography using only polyimethylsiloxsane. The proposed working principle was verified through simulation of the static deformation of the cascaded actuator diaphragms and the actuator, as well as tested experimentally. The dual operational modes of the proposed device (i.e., rubber-seal valve and peristaltic pumping mode) were also verified and successfully demonstrated in a liquid pumping test of the single and double pumps.

  7. A mathematical model for the peristaltic flow of chyme movement in small intestine.

    Science.gov (United States)

    Tripathi, Dharmendra

    2011-10-01

    A mathematical model based on viscoelastic fluid (fractional Oldroyd-B model) flow is considered for the peristaltic flow of chyme in small intestine, which is assumed to be in the form of an inclined cylindrical tube. The peristaltic flow of chyme is modeled more realistically by assuming that the peristaltic rush wave is a sinusoidal wave, which propagates along the tube. The governing equations are simplified by making the assumptions of long wavelength and low Reynolds number. Analytical approximate solutions of problem are obtained by using homotopy analysis method and convergence of the obtained series solution is properly checked. For the realistic values of the emerging parameters such as fractional parameters, relaxation time, retardation time, Reynolds number, Froude number and inclination of tube, the numerical results for the pressure difference and the frictional force across one wavelength are computed and discussed the roles played by these parameters during the peristaltic flow. On the basis of this study, it is found that the first fractional parameter, relaxation time and Froude number resist the movement of chyme, while, the second fractional parameter, retardation time, Reynolds number and inclination of tube favour the movement of chyme through the small intestine during pumping. It is further revealed that size of trapped bolus reduces with increasing the amplitude ratio whereas it is unaltered with other parameters. PMID:21802431

  8. Peristaltic flow of a Maxwell fluid in a channel with compliant walls

    Energy Technology Data Exchange (ETDEWEB)

    Ali, Nasir [Department of Mathematics, Quaid-i-Azam University 45320, Islamabad 44000 (Pakistan)], E-mail: nasirali_qau@yahoo.com; Hayat, Tasawar [Department of Mathematics, Quaid-i-Azam University 45320, Islamabad 44000 (Pakistan); Asghar, Saleem [Department of Mathematical Sciences, COMSATS Institute of Information Technology, Islamabad (Pakistan)

    2009-01-15

    This paper describes the peristaltic motion of a non-Newtonian fluid in a channel having compliant boundaries. Constitutive equations for a Maxwell fluid have been used. Perturbation method has been used for the analytic solution. The influence of pertinent parameters is analyzed. Comparison of the present analysis of Maxwell fluid is made with the existing results of viscous fluid.

  9. Slip and heat transfer effects on peristaltic motion of a Carreau fluid in an asymmetric channel

    Energy Technology Data Exchange (ETDEWEB)

    Hayat, Tasawar [Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Mathematics; King Saud Univ., Riyadh (Saudi Arabia). Dept. of Mathematics; Saleem, Najma [Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Mathematics; Hendi, Awatif A. [Dept. of Physics, Riyadh (Saudi Arabia). Faculty of Science

    2010-12-15

    An analysis has been carried out for peristaltic flow and heat transfer of a Carreau fluid in an asymmetric channel with slip effect. The governing problem is solved under long wavelength approximation. The variations of pertinent dimensionless parameters on temperature are discussed. Pumping and trapping phenomena are studied. (orig.)

  10. Slip effects on the magnetohydrodynamic peristaltic flow of a maxwell fluid

    Energy Technology Data Exchange (ETDEWEB)

    Hayat, Tasawar [Quiad-I-Azam Univ., Islamabad (Pakistan). Dept. of Mathematics; King Saud Univ., Riyadh (Saudi Arabia). Dept. of Mathematics; Hina, Sadia [Quiad-I-Azam Univ., Islamabad (Pakistan). Dept. of Mathematics; Hendi, Awatif A. [Dept. of Physics, Riyadh (Saudi Arabia). Faculty of Science

    2010-12-15

    The influence of slip on the magnetohydrodynamic (MHD) peristaltic flow in a planar channel with compliant walls is examined. An incompressible Maxwell fluid saturates the porous medium. An established solution is valid for small wave number. The mathematical expression of the stream function is presented. Several interesting flow parameters are sketched and examined. (orig.)

  11. Deformation analysis of a film-overlapped micro-pump membrane structure

    International Nuclear Information System (INIS)

    A novel approach is developed to study a film-overlapped membrane structure. Meanwhile, the established model is employed to design the micro-pump membrane structure and to evaluate its pumping efficiency. Two-dimensional coupling effects between the overlapping actuator films and the deformable membrane are thoroughly investigated, including the influences on the membrane from the overlapping films' elongation effects, Poisson's ratio effects and shear strain effects. Overall deformations and interactions for the three-layer membrane structures are accurately calculated through exercising the developed model, in contrast to what difficulties are usually encountered in carrying out FEM methods with very thin elements meshed for the actuator films. Furthermore, this study demonstrates that the high stiffness of the actuating metal films needs to be reflected in the equivalent stiffness of the membrane structures, especially when the sizes of the actuator films become compatible with the sizes of the membranes. Hence, the optimal micro-pumping efficiency of a membrane structure is acquired upon exercising the developed model, and larger sizes of the actuating films do not definitely obtain larger pumping efficiencies for the electromagnetically actuated micro-pumps

  12. Caterpillar locomotion-inspired valveless pneumatic micropump using a single teardrop-shaped elastomeric membrane

    KAUST Repository

    So, Hongyun

    2014-01-01

    This paper presents a microfluidic pump operated by an asymmetrically deformed membrane, which was inspired by caterpillar locomotion. Almost all mechanical micropumps consist of two major components of fluid halting and fluid pushing parts, whereas the proposed caterpillar locomotion-inspired micropump has only a single, bilaterally symmetric membrane-like teardrop shape. A teardrop-shaped elastomeric membrane was asymmetrically deformed and then consecutively touched down to the bottom of the chamber in response to pneumatic pressure, thus achieving fluid pushing. Consecutive touchdown motions of the teardrop-shaped membrane mimicked the propagation of a caterpillar\\'s hump during its locomotory gait. The initial touchdown motion of the teardrop-shaped membrane at the centroid worked as a valve that blocked the inlet channel, and then, the consecutive touchdown motions pushed fluid in the chamber toward the tail of the chamber connected to the outlet channel. The propagation of the touchdown motion of the teardrop-shaped membrane was investigated using computational analysis as well as experimental studies. This caterpillar locomotion-inspired micropump composed of only a single membrane can provide new opportunities for simple integration of microfluidic systems. © the Partner Organisations 2014.

  13. Caterpillar locomotion-inspired valveless pneumatic micropump using a single teardrop-shaped elastomeric membrane.

    Science.gov (United States)

    So, Hongyun; Pisano, Albert P; Seo, Young Ho

    2014-07-01

    This paper presents a microfluidic pump operated by an asymmetrically deformed membrane, which was inspired by caterpillar locomotion. Almost all mechanical micropumps consist of two major components of fluid halting and fluid pushing parts, whereas the proposed caterpillar locomotion-inspired micropump has only a single, bilaterally symmetric membrane-like teardrop shape. A teardrop-shaped elastomeric membrane was asymmetrically deformed and then consecutively touched down to the bottom of the chamber in response to pneumatic pressure, thus achieving fluid pushing. Consecutive touchdown motions of the teardrop-shaped membrane mimicked the propagation of a caterpillar's hump during its locomotory gait. The initial touchdown motion of the teardrop-shaped membrane at the centroid worked as a valve that blocked the inlet channel, and then, the consecutive touchdown motions pushed fluid in the chamber toward the tail of the chamber connected to the outlet channel. The propagation of the touchdown motion of the teardrop-shaped membrane was investigated using computational analysis as well as experimental studies. This caterpillar locomotion-inspired micropump composed of only a single membrane can provide new opportunities for simple integration of microfluidic systems. PMID:24812661

  14. The NeuroMedicator—a micropump integrated with silicon microprobes for drug delivery in neural research

    International Nuclear Information System (INIS)

    The NeuroMedicator is a micropump integrated with application-specific silicon microprobes aimed for drug delivery in neural research with small animals. The micropump has outer dimensions of 11 × 15 × 3 mm3 and contains 16 reservoirs each having a capacity of 0.25 µL. Thereby, the reservoirs are interconnected in a pearl-chain-like manner and are connected to two 8 mm long silicon microprobes. Each microprobe has a cross-sectional area of 250 × 250 µm2 and features an integrated drug delivery channel of 50 × 50 µm2 with an outlet of 25 µm in diameter. The drug is loaded to the micropump prior to implantation. After implantation, individual 0.25 µL portions of drug can be sequentially released by short heating pulses applied to a polydimethylsiloxane (PDMS) layer containing Expancel® microspheres. Due to local, irreversible thermal expansion of the elastic composite material, the drug is displaced from the reservoirs and released through the microprobe outlet directly to the neural tissue. While implanted, leakage of drug by diffusion occurs due to the open microprobe outlets. The maximum leakage within the first three days after implantation is calculated to be equivalent to 0.06 µL of drug solution. (paper)

  15. Development of micropump-actuated negative pressure pinched injection for parallel electrophoresis on array microfluidic chip.

    Science.gov (United States)

    Li, Bowei; Jiang, Lei; Xie, Hua; Gao, Yan; Qin, Jianhua; Lin, Bingcheng

    2009-09-01

    A micropump-actuated negative pressure pinched injection method is developed for parallel electrophoresis on a multi-channel LIF detection system. The system has a home-made device that could individually control 16-port solenoid valves and a high-voltage power supply. The laser beam is excitated and distributes to the array separation channels for detection. The hybrid Glass-PDMS microfluidic chip comprises two common reservoirs, four separation channels coupled to their respective pneumatic micropumps and two reference channels. Due to use of pressure as a driving force, the proposed method has no sample bias effect for separation. There is only one high-voltage supply needed for separation without relying on the number of channels, which is significant for high-throughput analysis, and the time for sample loading is shortened to 1 s. In addition, the integrated micropumps can provide the versatile interface for coupling with other function units to satisfy the complicated demands. The performance is verified by separation of DNA marker and Hepatitis B virus DNA samples. And this method is also expected to show the potential throughput for the DNA analysis in the field of disease diagnosis. PMID:19681052

  16. Study of valveless electromagnetic micropump by volume-of-fluid and OpenFOAM

    Science.gov (United States)

    Quang Dich, Nguyen; Dinh, Thien Xuan; Pham, Phuc Hong; Thanh Dau, Van

    2015-05-01

    The paper reports the first study on the backpressure of a valveless electromagnetic micropump using the volume-of-fluid (VOF) technique and open-source code OpenFOAM. The micropump consists of a vibrating diaphragm and fluidic microchannel connected to inlet and outlet tubes. The imbalance in fluid resistance of the fluidic microchannel during a vibration cycle of the diaphragm creates backpressure in the pump, which in turn produces a difference in water level between the inlet and outlet tubes. In this study, VOF was used in a transient simulation to obtain this difference in water level and then the backpressure. The obtained backpressure showed a slight discrepancy with the experimental data. The discrepancy was probably due to the difference in the wall surface quality of the fluidic microchannel between the simulation model and experimental device. These results are useful for analytical and numerical research on these types of micropumps and can easily be applied in an open-source code simulator with almost zero cost.

  17. Peristaltic Pumping of Blood Through Small Vessels of Varying Cross-Section

    Science.gov (United States)

    Misra, J. C.; Maiti, S.

    2012-11-01

    The paper is devoted to a study of the peristaltic motion of blood in the micro-circulatory system. The vessel is considered to be of varying cross-section. The progressive peristaltic waves are taken to be of sinusoidal nature. Blood is considered to be a Herschel-Bulkley fluid. Of particular concern here is to investigate the effects of amplitude ratio, mean pressure gradient, yield stress and the power law index on the velocity distribution, streamline pattern and wall shear stress. On the basis of the derived analytical expression, extensive numerical calculations have been made. The study reveals that velocity of blood and wall shear stress are appreciably affected due to the non-uniform geometry of blood vessels. They are also highly sensitive to the magnitude of the amplitude ratio and the value of the fluid index.

  18. Magnetic Field and Gravity Effects on Peristaltic Transport of a Jeffrey Fluid in an Asymmetric Channel

    Directory of Open Access Journals (Sweden)

    A. M. Abd-Alla

    2014-01-01

    Full Text Available In this paper, the peristaltic flow of a Jeffrey fluid in an asymmetric channel has been investigated. Mathematical modeling is carried out by utilizing long wavelength and low Reynolds number assumptions. Closed form expressions for the pressure gradient, pressure rise, stream function, axial velocity, and shear stress on the channel walls have been computed numerically. Effects of the Hartmann number, the ratio of relaxation to retardation times, time-mean flow, the phase angle and the gravity field on the pressure gradient, pressure rise, streamline, axial velocity, and shear stress are discussed in detail and shown graphically. The results indicate that the effect of Hartmann number, ratio of relaxation to retardation times, time-mean flow, phase angle, and gravity field are very pronounced in the peristaltic transport phenomena. Comparison was made with the results obtained in the presence and absence of magnetic field and gravity field.

  19. Efficient worm-like locomotion: slip and control of soft-bodied peristaltic robots

    International Nuclear Information System (INIS)

    In this work, we present a dynamic simulation of an earthworm-like robot moving in a pipe with radially symmetric Coulomb friction contact. Under these conditions, peristaltic locomotion is efficient if slip is minimized. We characterize ways to reduce slip-related losses in a constant-radius pipe. Using these principles, we can design controllers that can navigate pipes even with a narrowing in radius. We propose a stable heteroclinic channel controller that takes advantage of contact force feedback on each segment. In an example narrowing pipe, this controller loses 40% less energy to slip compared to the best-fit sine wave controller. The peristaltic locomotion with feedback also has greater speed and more consistent forward progress. (paper)

  20. Peristaltic Creeping Flow of Power Law Physiological Fluids through a Nonuniform Channel with Slip Effect

    OpenAIRE

    M. K. Chaube; Tripathi, D.; O. Anwar Bég; Shashi Sharma; PANDEY, V.S.

    2015-01-01

    A mathematical study on creeping flow of non-Newtonian fluids (power law model) through a nonuniform peristaltic channel, in which amplitude is varying across axial displacement, is presented, with slip effects included. The governing equations are simplified by employing the long wavelength and low Reynolds number approximations. The expressions for axial velocity, stream function, pressure gradient, and pressure difference are obtained. Computational and numerical results for velocity profi...

  1. PERISTALTIC TRASPORTATION WITH EFFECT OF MAGNETIC FIELD IN A FLEXIBLE CHANNEL UNDER AN OSCILATORY FLUX

    OpenAIRE

    Dr.S.Ravi kumar

    2013-01-01

    In this paper we have analyzed the flow of a couple stress fluids in a channel bounded by flexible walls over which a traveling wave of contraction and expansion is imposed resulting in a peristaltic motion. An oscillatory time dependent flow is also imposed on this flow. The non-linear equations governing the flow through magnetic field are solved under long wavelength approximation. The existence of separation in the flow field is discussed for different values of the governing parameters. ...

  2. Effect of induced magnetic field on peristaltic flow of a micropolar fluid in an asymmetric channel

    OpenAIRE

    Shit, G. C.; Roy, M.; E. Y. K. Ng

    2010-01-01

    Of concern in this paper is an investigation of peristaltic transport of a physiological fluid in an asymmetric channel under long wave length and low-Reynolds number assumptions. The flow is assumed to be incompressible, viscous, electrically conducting micropolar fluid and the effect of induced magnetic field is taken into account. Exact analytical solutions obtained for the axial velocity, microrotation component, stream line pattern, magnetic force function, axial-induced magnetic field a...

  3. Peristaltic transport of Johnson-Segalman fluid under effect of a magnetic field

    Directory of Open Access Journals (Sweden)

    Moustafa Elshahed

    2005-01-01

    Full Text Available The peristaltic transport of Johnson-Segalman fluid by means of an infinite train of sinusoidal waves traveling along the walls of a two-dimensional flexible channel is investigated. The fluid is electrically conducted by a transverse magnetic field. A perturbation solution is obtained for the case in which amplitude ratio is small. Numerical results are reported for various values of the physical parameters of interest.

  4. Non-Newtonian effects in the peristaltic flow of a Maxwell fluid

    OpenAIRE

    Tsiklauri, D.; Beresnev, I.

    2001-01-01

    We analyzed the effect of viscoelasticity on the dynamics of fluids in porous media by studying the flow of a Maxwell fluid in a circular tube, in which the flow is induced by a wave traveling on the tube wall. The present study investigates novelties brought about into the classic peristaltic mechanism by inclusion of non-Newtonian effects that are important, for example, for hydrocarbons. This problem has numerous applications in various branches of science, including stimulation of fluid f...

  5. A Mathematical Model for Studying the Slip Effect on Peristaltic Motion with Heat and Mass Transfer

    Institute of Scientific and Technical Information of China (English)

    Tasawar Hayat; Najma Saleem; Awatif A. Hendi

    2011-01-01

    A mathematical model is presented with an interest to examine the peristaltic motion in an asymmetric channel by taking into account the slip, heat and mass transfer. Constitutive relationships for a micropolar fluid are used. The solution procedure for nonlinear analysis is given under long wavelength and low Reynolds number approximations. The effects of sundry parameters entering into the expressions of axial velocity,temperature and concentration are explored. Pumping and trapping phenomena are discussed.

  6. Particle motion in unsteady two-dimensional peristaltic flow with application to the ureter

    Science.gov (United States)

    Jiménez-Lozano, Joel; Sen, Mihir; Dunn, Patrick F.

    2009-04-01

    Particle motion in an unsteady peristaltic fluid flow is analyzed. The fluid is incompressible and Newtonian in a two-dimensional planar geometry. A perturbation method based on a small ratio of wave height to wavelength is used to obtain a closed-form solution for the fluid velocity field. This analytical solution is used in conjunction with an equation of motion for a small rigid sphere in nonuniform flow taking Stokes drag, virtual mass, Faxén, Basset, and gravity forces into account. Fluid streamlines and velocity profiles are calculated. Theoretical values for pumping rates are compared with available experimental data. An application to ureteral peristaltic flow is considered since fluid flow in the ureter is sometimes accompanied by particles such as stones or bacteriuria. Particle trajectories for parameters that correspond to calcium oxalates for calculosis and Escherichia coli type for bacteria are analyzed. The findings show that retrograde or reflux motion of the particles is possible and bacterial transport can occur in the upper urinary tract when there is a partial occlusion of the wave. Dilute particle mixing is also investigated, and it is found that some of the particles participate in the formation of a recirculating bolus, and some of them are delayed in transit and eventually reach the walls. This can explain the failure of clearing residuals from the upper urinary tract calculi after successful extracorporeal shock wave lithotripsy. The results may also be relevant to the transport of other physiological fluids and industrial applications in which peristaltic pumping is used.

  7. Peristaltic flow in non-uniform vessels of the micro-circulatory system

    CERN Document Server

    Maiti, S

    2013-01-01

    Of concern in the paper is generalized a theoretical study concerning the peristaltic flow of blood in the micro-circulatory system. The vessel is considered to be of non-uniform cross-section and blood to be a non-Newtonian fluid. The progressive wave front of the peristaltic flow is supposed sinusoidal/straight section dominated (SSD) (expansion/contraction type); Reynolds number is considered to be small with reference to the flow of physiological fluids. The non-Newtonian behaviour of blood is illustrated by considering the Herschel-Bulkley fluid model. The objective of the study has been to examine the effect of the effects of amplitude ratio, mean pressure gradient, yield stress and the power law index on the velocity distribution, wall shear stress, streamline pattern and trapping. Considerable quantitative differences between the results obtained for transport in two dimensional channel and an axisymmetric circular tube are noticed. The study shows that peristaltic pumping, flow velocity and wall shea...

  8. Gastrointestinal monitor: automatic titration of jejunal inflow to match peristaltic outflow.

    Science.gov (United States)

    Moss, Gerald; Posada, Jose G

    2007-06-15

    A peristaltic gradient insures that chyme normally removed from the jejunal feeding site continues to be propelled caudad. The trigger for iatrogenic "feeding intolerance" is the inadvertently overwhelming of the jejunum's peristaltic outflow, even momentarily. Even minimum local stasis can stimulate a vagal reflex response. Motility of the sluggish gut further slows, leading to generalized abdominal distention, malaise, immobility, and impaired respiratory mechanics. Vagal vascular reflexes could explain the 1:1000 incidence of bowel necrosis for jejunally fed patients. We developed a clinical regimen that continuously "checks for residual" at the enteral feeding site, monitoring the adequacy of emptying. The jejunal inflow automatically is titrated to match peristaltic outflow if the latter cannot keep up. Intermittent suction aspirates the feeding catheter into a plastic chamber for 30 s. All swallowed air is removed efficiently within the close confines of the jejunal segment, without wasting digestive juices. The degassed aspirate is returned by gravity with the feedings during the second half of the 1-min cycle, unless incipient excess (>or=20 mL) fluid overflows. Only this relatively small volume of potentially excess fluid is discarded, forestalling the local distention. All patients tolerated immediate feeding without discomfort or abdominal distention, including three that had esophageal resection (including vagotomy) for carcinoma. Postoperative full enteral nutrition can be achieved quickly and safely with minimum attention, despite initially marginal gastrointestinal function. PMID:17509263

  9. The Structure of Wheel Check Valve Influence on Air Block Phenomenon of Piezoelectric Micro-Pump

    OpenAIRE

    Song Chen; Yong Liu; Yanhu Shen; Jiantao Wang; Zhigang Yang

    2015-01-01

    To improve the stability and reliability of the piezoelectric micro-pump, the cause of air block phenomenon is analyzed on the structure of wheel check valve. During the movement of the bubble in the micro-channel, pressure drop occurs, the main factor which influences the bubble going through is opening height of the wheel check valve. Five groups of wheel check valves with different structures are used to test the wheel check valve opening height and air block probability. The experiment re...

  10. Development and Application of a Diaphragm Micro-Pump with Piezoelectric Device

    OpenAIRE

    Ma, H K; Hou, B.R.; Wu, H Y; Lin, C.Y.; Gao, J. J.; Kou, M. C.

    2008-01-01

    In this study, a new type of thin, compact, and light weighed diaphragm micro-pump has been successfully developed to actuate the liquid by the vibration of a diaphragm. The micro-diaphragm pump with two valves is fabricated in an aluminum case by using highly accurate CNC machine, and the cross-section dimension is 5mm x 8mm. Both valves and diaphragm are manufactured from PDMS. The amplitude of vibration by a piezoelectric device produces an oscillating flow which may change the chamber vol...

  11. Finite Element analysis of a shape memory alloy actuator for a micropump

    OpenAIRE

    Merzouki, Tarek; Duval, Arnaud; BEN ZINEB, Tarak

    2012-01-01

    This paper deals with a Finite Element (FE) behavior analysis of a shape memory alloy actuator for a micropump. It is composed of two membranes of NiTi shape memory alloy (SMA) in a martensitic state at room temperature. They have an initial flat shape and are bonded together with an intermediate spacer. The thermal loading allows the actuator to move up and down in the membrane normal direction. A detailed analysis of sensibility to material and geometric parameters of the SMA actuator is un...

  12. Development of an electrohydrodynamic ion-drag micropump using three-dimensional carbon micromesh electrodes

    International Nuclear Information System (INIS)

    An electrohydrodynamic (EHD) ion-drag micropump using three-dimensional carbon micromesh electrodes was developed. The carbon micromesh electrodes were created by the pyrolysis of SU-8 structures. The carbon electrodes and microchannel were formed on a quartz substrate, and the microchannel was sealed by an SU-8 slab structure. The pumping behaviors were evaluated using Fluorinert as a non-conductive sample solution. The maximum pressure and volume flow rate were approximately 23 Pa and 400 nL/min, respectively, under an applied voltage of 500 V. (paper)

  13. ac electrokinetic micropumps: The effect of geometrical confinement, Faradaic current injection, and nonlinear surface capacitance

    DEFF Research Database (Denmark)

    Olesen, Laurits Højgaard; Bruus, Henrik; Ajdari, A.

    2006-01-01

    Recent experiments have demonstrated that ac electrokinetic micropumps permit integrable, local, and fast pumping (velocities similar to mm/s) with low driving voltage of a few volts only. However, they also displayed many quantitative and qualitative discrepancies with existing theories. We...... therefore extend the latter theories to account for three experimentally relevant effects: (i) vertical confinement of the pumping channel, (ii) Faradaic currents from electrochemical reactions at the electrodes, and (iii) nonlinear surface capacitance of the Debye layer. We report here that these effects...... indeed affect the pump performance in a way that we can rationalize by physical arguments....

  14. Simulation of the fluidic features for diffuser/nozzle involved in a PZT-based valveless micropump

    Institute of Scientific and Technical Information of China (English)

    HouWensheng; Zheng Xiaolin; Biswajit Das; Jiang Yingtao; Qian Shizhi; Wu Xiaoying; Zheng Zhigao

    2008-01-01

    PZT-based valveless micropump is a microactuator that can be used for controlling and delivering tiny amounts of fluids, and diffuser/nozzle plays an important role when this type of micropump drives the fluid flowing along a specific direction. In this paper, a numerical model of micropump has been proposed, and the fluidic properties of diffuser/nozzle have been simulated with ANSYS. With the method of finite-element analysis, the increased pressure drop between inlet and outlet of diffuser/nozzle induces the increment of flow rate in both diffuser and nozzle simultaneously, but the increasing rate of diffuser is faster than that of nozzle. The L/R, ratio of L (length of cone pipe) and R (radius of minimal cross section of cone pipe) plays an important role in fluidic performance of diffuser and nozzle as well, and the mean flow rate will decrease with increment of L/R. The mean flow rate reaches its peak value when L/R with the value of 10 regardless the divergence angle of diffuser or nozzle. The simulation results indicate that the fluidic properties of diffuser/nozzle can be defined by its geometric structure, and accordingly determine the efficiency of micropump.

  15. A Comparative Study of Nozzle/Diffuser Micropumps with Novel Valves

    Directory of Open Access Journals (Sweden)

    Jin-Cherng Shyu

    2012-02-01

    Full Text Available This study conducts an experimental study concerning the improvement of nozzle/diffuser micropump design using some novel no-moving-part valves. A total of three micropumps, including two enhancement structures having two-fin or obstacle structure and one conventional micro nozzle/diffuser design, are made and tested in this study. It is found that dramatic increase of the pressure drops across the designed micro nozzles/diffusers are seen when the obstacle or fin structure is added. The resultant maximum flow rates are 47.07 mm3/s and 53.39 mm3/s, respectively, for the conventional micro nozzle/diffuser and the added two-fin structure in micro nozzle/diffuser operated at a frequency of 400 Hz. Yet the mass flow rate for two-fin design surpasses that of conventional one when the frequency is below 425 Hz but the trend is reversed with a further increase of frequency. This is because the maximum efficiency ratio improvement for added two-fin is appreciably higher than the other design at a lower operating frequency. In the meantime, despite the efficiency ratio of the obstacle structure also reveals a similar trend as that of two-fin design, its significant pressure drop (flow resistance had offset its superiority at low operating frequency, thereby leading to a lesser flow rate throughout the test range.

  16. Study on an alternating current electrothermal micropump for microneedle-based fluid delivery systems

    Science.gov (United States)

    Zhang, Rumi; Jullien, Graham A.; Dalton, Colin

    2013-07-01

    In this paper, we report on a modeling study of an AC electrothermal (ACET) micropump with high operating pressures as well as fast flow rates. One specific application area is for fluid delivery using microneedle arrays which require higher pressures and faster flow rates than have been previously reported with ACET devices. ACET is very suitable for accurate actuation and control of fluid flow, since the technique has been shown to be very effective in high conductivity fluids and has the ability to create a pulsation free flow. However, AC electrokinetic pumps usually can only generate low operating pressures of 1 to 100 Pa, where flow reversal is likely to occur with an external load. In order to realize a high performance ACET micropump for continuous fluid delivery, applying relatively high AC operating voltages (20 to 36 Vrms) to silicon substrate ACET actuators and using long serpentine channel allows the boosting of operating pressure as well as increasing the flow rates. Fast pumping flow rates (102-103 nl/s) and high operating pressures (1-12 kPa) can be achieved by applying both methods, making them of significant importance for continuous fluid delivery applications using microneedle arrays and other such biomedical devices.

  17. Numerical and analytical treatment on peristaltic flow of Williamson fluid in the occurrence of induced magnetic field

    International Nuclear Information System (INIS)

    In this paper the effects of induced magnetic field on the peristaltic transport of a Williamson fluid model in an asymmetric channel has been investigated. The problem is simplified by using long wave length and low Reynolds number approximations. The perturbation and numerical solutions have been presented. The expressions for pressure rise, pressure gradient, stream function, magnetic force function, current density distribution have been computed. The results of pertinent parameters have been discussed graphically. The trapping phenomena for different wave forms have been also discussed. - highlights: • The main motivation of this work is that we want to see the behavior of peristaltic flow of Williamson fluid in the occurrence of induced magnetic field. In literature no attempt is taken to discuss the lateral Numerical and analytical treatment on peristaltic flow of Williamson fluid in the occurrence of induced magnetic field. • We do not want to fill the gap in literature after studying this

  18. A Peristaltic Micro Pump Driven by a Rotating Motor with Magnetically Attracted Steel Balls

    OpenAIRE

    Zhaoying Zhou; Kang Wu; Xiongying Ye; Min Du

    2009-01-01

    In this paper, we present a membrane peristaltic micro pump driven by a rotating motor with magnetically attracted steel balls for lab-on-a-chip applications. The fabrication process is based on standard soft lithography technology and bonding of a PDMS layer with a PMMA substrate. A linear flow rate range ~490 μL/min was obtained by simply varying the rotation speed of a DC motor, and a maximum back pressure of 592 Pa was achieved at a rotation speed of 43 rpm. The flow rate of the pump can ...

  19. Peristaltic transport of Conducting Bingham fluid in contact with a Newtonian fluid in a channel

    Directory of Open Access Journals (Sweden)

    M.Arun kumar

    2013-04-01

    Full Text Available Peristaltic pumping by a sinusoidal traveling wave in the walls of a two dimensional channel filled with two immiscible fluids with magnetic effect is investigated. The core region of the channel is occupied by a Bingham fluid where as the peripheral region is occupied by a Newtonian fluid. The flow is examined in a wave frame of reference moving with the velocity of the wave. The expressions for the stream function, the velocity and the pressure rise are obtained. The equation for the interface separating the two fluids is obtained. Numerical results are reported for several of the physical parameters of interest. We observed that the lower values of

  20. Magnetohydrodynamic Peristaltic Flow of a Pseudoplastic Fluid in a Curved Channel

    Science.gov (United States)

    Noreen, Saima; Hayat, Tasawar; Alsaedi, Ahmed

    2013-05-01

    A mathematical model is developed to examine the effects of an induced magnetic field on the peristaltic flow in a curved channel. The non-Newtonian pseudoplastic fluid model is used to depict the combined elastic and viscous properties. The analysis has been carried out in the wave frame of reference, long wavelength and low Reynolds scheme are implemented. A series solution is obtained through perturbation analysis. Results for stream function, pressure gradient, magnetic force function, induced magnetic field, and current density are constructed. The effects of significant parameters on the flow quantities are sketched and discussed.

  1. Influence of convective conditions in radiative peristaltic flow of pseudoplastic nanofluid in a tapered asymmetric channel

    Science.gov (United States)

    Hayat, T.; Iqbal, Rija; Tanveer, Anum; Alsaedi, A.

    2016-06-01

    This paper looks at the influences of magnetohydrodynamics (MHD) and thermal radiation on peristaltic transport of a pseudoplastic nanofluid in a tapered asymmetric channel. The tapered channel walls satisfy convective boundary conditions. The governing equations for the balance of mass, momentum, temperature and volume fraction for pseudoplastic nanofluid are first formulated and then utilized for long wavelength and small Reynolds number considerations. Effects of involved parameters on the flow characteristics have been plotted and examined. It is observed that the heat transfer Biot number shows a dual behavior on the temperature of nanofluid particles whereas the mass transfer Biot number with its increasing values enhances the fluid temperature.

  2. Peristaltic flow in an asymmetric channel with convective boundary conditions and Joule heating

    Institute of Scientific and Technical Information of China (English)

    Abbasi Fahad Munir; Hayat Tasawar; Ahmad Bashir

    2014-01-01

    The peristaltic transport of viscous fluid in an asymmetric channel is concentrated. The channel walls exhibit convective boundary conditions. Both cases of hydrodynamic and magnetohydrodynamic (MHD) fluids are considered. Mathematical analysis has been presented in a wave frame of reference. The resulting problems are non-dimensionalized. Long wavelength and low Reynolds number approximations are employed. Joule heating effect on the thermal equation is retained. Analytic solutions for stream function and temperature are constructed. Numerical integration is carried out for pressure rise per wavelength. Effects of influential flow parameters have been pointed out through graphs.

  3. Magnetohydrodynamic peristaltic flow of a hyperbolic tangent fluid in a vertical asymmetric channel with heat transfer

    Institute of Scientific and Technical Information of China (English)

    Sohail Nadeem; Safia Akram

    2011-01-01

    In the present paper we discuss the magnetohydrodynamic (MHD) peristaltic flow of a hyperbolic tangent fluid model in a vertical asymmetric channel under a zero Reynolds number and long wavelength approximation. Exact solution of the temperature equation in the absence of dissipation term has been computed and the analytical expression for stream function and axial pressure gradient are established. The flow is analyzed in a wave frame of reference moving with the velocity of wave. The expression for pressure rise has been computed numerically. The physical features of pertinent parameters are analyzed by plotting graphs and discussed in detail.

  4. Peristaltic transport of a fractional Burgers' fluid with variable viscosity through an inclined tube

    Science.gov (United States)

    Rachid, Hassan

    2015-12-01

    In the present study,we investigate the unsteady peristaltic transport of a viscoelastic fluid with fractional Burgers' model in an inclined tube. We suppose that the viscosity is variable in the radial direction. This analysis has been carried out under low Reynolds number and long-wavelength approximations. An analytical solution to the problem is obtained using a fractional calculus approach. Figures are plotted to show the effects of angle of inclination, Reynolds number, Froude number, material constants, fractional parameters, parameter of viscosity and amplitude ratio on the pressure gradient, pressure rise, friction force, axial velocity and on the mechanical efficiency.

  5. Mixed convection peristaltic flow of third order nanofluid with an induced magnetic field.

    Directory of Open Access Journals (Sweden)

    Saima Noreen

    Full Text Available This research is concerned with the peristaltic flow of third order nanofluid in an asymmetric channel. The governing equations of third order nanofluid are modelled in wave frame of reference. Effect of induced magnetic field is considered. Long wavelength and low Reynolds number situation is tackled. Numerical solutions of the governing problem are computed and analyzed. The effects of Brownian motion and thermophoretic diffusion of nano particles are particularly emphasized. Physical quantities such as velocity, pressure rise, temperature, induced magnetic field and concentration distributions are discussed.

  6. Peristaltic flow of Johnson-Segalman fluid in asymmetric channel with convective boundary conditions

    Institute of Scientific and Technical Information of China (English)

    H YASMIN; T HAYAT; A ALSAEDI; HH ALSULAMI

    2014-01-01

    This work is concerned with the peristaltic transport of the Johnson-Segalman fluid in an asymmetric channel with convective boundary conditions. The mathematical modeling is based upon the conservation laws of mass, linear momentum, and energy. The resulting equations are solved after long wavelength and low Reynolds number are used. The results for the axial pressure gradient, velocity, and temperature profiles are obtained for small Weissenberg number. The expressions of the pressure gra-dient, velocity, and temperature are analyzed for various embedded parameters. Pumping and trapping phenomena are also explored.

  7. Effect of Slip on Peristaltic Flow of Powell-Eyring Fluid in a Symmetric Channel

    Directory of Open Access Journals (Sweden)

    T. Hayat

    2014-01-01

    Full Text Available Peristaltic flow of non-Newtonian fluid in a symmetric channel with partial slip effect is examined. The non-Newtonian behavior of fluid is characterized by the constitutive equations of Powell-Eyring fluid. The motion is induced by a sinusoidal wave traveling along the flexible walls of channel. The flow is analyzed in a wave frame of reference moving with the velocity of wave. The equations governing the flow are solved by adopting lubrication approach. Series solutions for the stream function and axial pressure gradient are obtained. Impact of slip and other emerging flow parameters is plotted and analyzed graphically.

  8. Radiative Peristaltic Flow of Jeffrey Nanofluid with Slip Conditions and Joule Heating

    Science.gov (United States)

    Hayat, Tasawar; Shafique, Maryam; Tanveer, Anum; Alsaedi, Ahmed

    2016-01-01

    Mixed convection peristaltic flow of Jeffrey nanofluid in a channel with compliant walls is addressed here. The present investigation includes the viscous dissipation, thermal radiation and Joule heating. Whole analysis is performed for velocity, thermal and concentration slip conditions. Related problems through long wavelength and low Reynolds number are examined for stream function, temperature and concentration. Impacts of thermal radiation, Hartman number, Brownian motion parameter, thermophoresis, Joule heating and slip parameters are explored in detail. Clearly temperature is a decreasing function of Hartman number and radiation parameter. PMID:26886919

  9. Influence of thermal and velocity slip on the peristaltic flow of Cu-water nanofluid with magnetic field

    Science.gov (United States)

    Akbar, Noreen Sher

    2016-03-01

    The peristaltic flow of an incompressible viscous fluid containing copper nanoparticles in an asymmetric channel is discussed with thermal and velocity slip effects. The copper nanoparticles for the peristaltic flow water as base fluid is not explored so far. The equations for the purposed fluid model are developed first time in literature and simplified using long wavelength and low Reynolds number assumptions. Exact solutions have been calculated for velocity, pressure gradient, the solid volume fraction of the nanoparticles and temperature profile. The influence of various flow parameters on the flow and heat transfer characteristics is obtained.

  10. Influence of magnetic field on peristaltic flow of a Casson fluid in an asymmetric channel: Application in crude oil refinement

    Science.gov (United States)

    Sher Akbar, Noreen

    2015-03-01

    The influence of magnetic field on peristaltic flow of a Casson fluid model is considered. The model for peristaltic literature is modelled first time. The governing coupled equations are constructed under long wavelength and low Reynold's number approximation. Exact solutions are evaluated for stream function and pressure gradient. The important findings in this study are the variation of the Hartmann number M, Casson fluid parameter ζ and amplitudes a, b, d and ϕ. The velocity field increases due to increase in Hartmann number M near the channel walls while velocity field decreases at the centre of the channel.

  11. Soret and Dufour Effects on MHD Peristaltic Flow of Jeffrey Fluid in a Rotating System with Porous Medium

    Science.gov (United States)

    Hayat, Tasawar; Rafiq, Maimona; Ahmad, Bashir

    2016-01-01

    The objective of present paper is to examine the peristaltic flow of magnetohydrodynamic (MHD) Jeffrey fluid saturating porous space in a channel through rotating frame. Unlike the previous attempts, the flow formulation is based upon modified Darcy's law porous medium effect in Jeffrey fluid situation. In addition the impacts due to Soret and Dufour effects in the radiative peristaltic flow are accounted. Rosseland’s approximation has been utilized for the thermal radiative heat flux. Lubrication approach is implemented for the simplification. Resulting problems are solved for the stream function, temperature and concentration. Graphical results are prepared and analyzed for different parameters of interest entering into the problems. PMID:26808387

  12. Soret and Dufour Effects on MHD Peristaltic Flow of Jeffrey Fluid in a Rotating System with Porous Medium.

    Science.gov (United States)

    Hayat, Tasawar; Rafiq, Maimona; Ahmad, Bashir

    2016-01-01

    The objective of present paper is to examine the peristaltic flow of magnetohydrodynamic (MHD) Jeffrey fluid saturating porous space in a channel through rotating frame. Unlike the previous attempts, the flow formulation is based upon modified Darcy's law porous medium effect in Jeffrey fluid situation. In addition the impacts due to Soret and Dufour effects in the radiative peristaltic flow are accounted. Rosseland's approximation has been utilized for the thermal radiative heat flux. Lubrication approach is implemented for the simplification. Resulting problems are solved for the stream function, temperature and concentration. Graphical results are prepared and analyzed for different parameters of interest entering into the problems. PMID:26808387

  13. Design and Analysis of Piezoelectric Micro-Pump Using Traveling-Wave

    International Nuclear Information System (INIS)

    Since the development of microelectromechanical systems (MEMS) technology for the medical field, various micro-fluid transfer systems have been studied. This paper proposes a micro-piezoelectric pump that imitates a stomach's peristalsis by using two separate piezoelectric elements, in contrast to existing micro-pumps. This piezoelectric pump is operated by using the valve-less traveling wave of peristalsis movement. If the piezoelectric plates at the two separated plates are actuated at the input voltage, a traveling wave occurs between the two plates. Then, the fluid migrates by the pressure difference generated by the traveling wave. Finite element analysis was performed to understand the mechanics of the combined system with piezoelectric elements, elastic structures, and fluids. The effects of design variables such as the chamber height and number of ceramics on the flow rate of the fluid were examined

  14. Centrifugal Force Based Magnetic Micro-Pump Driven by Rotating Magnetic Fields

    International Nuclear Information System (INIS)

    This paper presents a centrifugal force based magnetic micro-pump for the pumping of blood. Most blood pumps are driven by an electrical motor with wired control. To develop a wireless and battery-free blood pump, the proposed pump is controlled by external rotating magnetic fields with a synchronized impeller. Synchronization occurs because the rotor is divided into multi-stage impeller parts and NdFeB permanent magnet. Finally, liquid is discharged by the centrifugal force of multi-stage impeller. The proposed pump length is 30 mm long and 19 mm in diameter which much smaller than currently pumps; however, its pumping ability satisfies the requirement for a blood pump. The maximum pressure is 120 mmHg and the maximum flow rate is 5000ml/min at 100 Hz. The advantage of the proposed pump is that the general mechanical problems of a normal blood pump are eliminated by the proposed driving mechanism.

  15. Characteristics of electrostatic gas micro-pump with integrated polyimide passive valves

    International Nuclear Information System (INIS)

    We report on the fabrication and characterization of electrostatic gas micro-pumps integrated with polyimide check valves. Touch-mode capacitance actuation, enabled by a fixed silicon electrode and a metal/polyimide diaphragm, creates the suction and push-out of the ambient gas; the gas flow is rectified by the check valves located at the inlet and outlet of the pump. The fabricated pumps were tested with various actuation voltages at different frequencies and duty cycles; an emphasis was placed on investigating the effect of valve flow conductance on the gas pumping characteristics. The pump with higher valve conductance could increase the operating frequency of the pump and affect the pumping characteristics from a pulsating flow to a continuous flow, leading to a higher gas flow rate. This electrostatic pump has a flow control resolution of 1 µL min−1; it could generate a gas flow up to 106 µL min−1. (paper)

  16. Characteristics of electrostatic gas micro-pump with integrated polyimide passive valves

    Science.gov (United States)

    Han, Jeahyeong; Yeom, Junghoon; Mensing, Glennys; Flachsbart, Bruce; Shannon, Mark A.

    2012-09-01

    We report on the fabrication and characterization of electrostatic gas micro-pumps integrated with polyimide check valves. Touch-mode capacitance actuation, enabled by a fixed silicon electrode and a metal/polyimide diaphragm, creates the suction and push-out of the ambient gas; the gas flow is rectified by the check valves located at the inlet and outlet of the pump. The fabricated pumps were tested with various actuation voltages at different frequencies and duty cycles; an emphasis was placed on investigating the effect of valve flow conductance on the gas pumping characteristics. The pump with higher valve conductance could increase the operating frequency of the pump and affect the pumping characteristics from a pulsating flow to a continuous flow, leading to a higher gas flow rate. This electrostatic pump has a flow control resolution of 1 µL min-1 it could generate a gas flow up to 106 µL min-1.

  17. NUMERICAL STUDY OF PERIODICAL FLOWS OF PIEZOELECTRIC VALVELESS MICROPUMP FOR BIOCHIPS

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yong-li; WU Jian-kang

    2005-01-01

    Shallow water model was employed to approximate the three-dimensional flows of a thin micropump to a two-dimensional thickness-averaged flows. The finite element method and pressure correction algorithm were used to solve the twodimensional flows of the pump and calculate the pump flow rate. The numerical results indicate that: 1 ) Phase differences in time of flow velocities and backflows occur across section of diffuser connecting to pump chamber; 2 ) A pair of symmetric vortexes appear inside the pump chamber at the end of suction flow phase; 3) The directional flow rate of the pump is dominated by nonlinearity of Navier-Stokes equations.Quantitative relations of the pump flow rate versus the ratio of diffuser length to width,the ratio of diffuser thickness to width, fluid viscosity and backpressure were also given. Possibly maximal flow rate can be achieved by optimizing the pump parameters.

  18. A magnetic shape memory micropump: contact-free, and compatible with PCR and human DNA profiling

    Science.gov (United States)

    Ullakko, K.; Wendell, L.; Smith, A.; Müllner, P.; Hampikian, G.

    2012-11-01

    Magnetic shape memory (MSM) Ni-Mn-Ga elements are relatively new materials with a variety of remarkable properties. They respond to changes in magnetic fields by elongating and shortening up to 6%. We have constructed a micropump which consists principally of a single component, the MSM element. The pump can be driven by the rotation of a diametrically magnetized cylindrical magnet or by an electrical rotation of the magnetic field; it is reversible, and can be effectively operated by hand without any electrical power. The MSM element does not inhibit the polymerase chain reaction. We demonstrate that it is compatible with forensic applications and show that it does not inhibit human DNA profiling. This novel pump is suitable for lab-on-a-chip applications that require microfluidics.

  19. A novel fabrication process to realize a valveless micropump on a flexible substrate

    Science.gov (United States)

    Wei, Yang; Torah, Russel; Yang, Kai; Beeby, Steve; Tudor, John

    2014-02-01

    This paper reports, for the first time, on the design, fabrication and testing of a planar valveless micropump, entirely screen printed onto a flexible polyimide (Kapton) substrate using sacrificial, structural, conductive and piezoelectric layers. The sacrificial layer, used to achieve a pump chamber and inlet/outlet channels, is removed using water followed by a 140 ° C heat treatment to evaporate the water from the structure. The fabrication process is analogous to a standard silicon based micro-electro-mechanical system sacrificial process. Applying a sinusoidal AC voltage to the piezoelectric layer drives a flexible membrane which pumps a liquid through the chamber. A maximum flow rate of 38 μl min-1 was achieved using a drive frequency of 3 kHz.

  20. A magnetic shape memory micropump: contact-free, and compatible with PCR and human DNA profiling

    International Nuclear Information System (INIS)

    Magnetic shape memory (MSM) Ni–Mn–Ga elements are relatively new materials with a variety of remarkable properties. They respond to changes in magnetic fields by elongating and shortening up to 6%. We have constructed a micropump which consists principally of a single component, the MSM element. The pump can be driven by the rotation of a diametrically magnetized cylindrical magnet or by an electrical rotation of the magnetic field; it is reversible, and can be effectively operated by hand without any electrical power. The MSM element does not inhibit the polymerase chain reaction. We demonstrate that it is compatible with forensic applications and show that it does not inhibit human DNA profiling. This novel pump is suitable for lab-on-a-chip applications that require microfluidics. (paper)

  1. Topology and shape optimization of induced-charge electro-osmotic micropumps

    DEFF Research Database (Denmark)

    Gregersen, Misha Marie; Okkels, Fridolin; Bazant, M. Z.; Bruus, Henrik

    2009-01-01

    For a dielectric solid surrounded by an electrolyte and positioned inside an externally biased parallel-plate capacitor, we study numerically how the resulting induced-charge electro-osmotic (ICEO) flow depends on the topology and shape of the dielectric solid. In particular, we extend existing...... conventional electrokinetic models with an artificial design field to describe the transition from the liquid electrolyte to the solid dielectric. Using this design field, we have succeeded in applying the method of topology optimization to find system geometries with non-trivial topologies that maximize the...... design field. Our results show the importance of the topology and shape of the dielectric solid in ICEO systems and point to new designs of ICEO micropumps with significantly improved performance....

  2. Experimental study of thermally-driven micro-pump using stepped laser

    Institute of Scientific and Technical Information of China (English)

    ZHOU Hong; HUAI Xiulan; LI Huazhi; LIU Dengying; MENG Qun

    2004-01-01

    The stepped pulse-laser is used to heat the fluid in a micro-tube with the diameter less than 1 mm, and a phase change and a directional flow of the fluid are induced. Based on many experimental observations, the mechanism of thermally-driven MEMS is studied and the technical approaches of the efficient and steady thermally-driven flow is given. The experimental results show that the hypostasis of the thermally-driven micro-pump is a kind of erratic liquid-vapor two-phase flow, and the liquid movement and the change rate of the pressure is closely related to the bubbles' behavior in the micro-tube.

  3. Nanoporous-Gold-Based Hybrid Cantilevered Actuator Dealloyed and Driven by A Modified Rotary Triboelectric Nanogenerator

    Science.gov (United States)

    Li, Xuequan; Liu, Mengmeng; Huang, Baisheng; Liu, Hong; Hu, Weiguo; Shao, Li-Hua; Wang, Zhong Lin

    2016-01-01

    We firstly designed an electrochemical system for dealloying to synthesize nanoporous gold (NPG) and also driving the novel NPG based actuator by utilizing a modified rotary triboelectric nanogenerator (TENG). Compared to the previous reported TENG whose outputs decline due to temperature rising resulting from electrodes friction, the modified TENG with a cooling system has stable output current and voltage increased by 14% and 20%, respectively. The novel cantilevered hybrid actuator characterised by light-weight (ca. 3 mg) and small volume (ca. 30 mm × 2 mm × 10 μm) is driven by a microcontroller modulated TENG with the displacement of 2.2 mm, which is about 106 times larger than that of traditional cantilever using planar surfaces. The energy conversion efficiencies defined as the energy consumed during dealloying and actuation compared with the output of TENG are 47% and 56.7%, respectively. PMID:27063987

  4. Magnetic field and rotation effects on peristaltic transport of a Jeffrey fluid in an asymmetric channel

    International Nuclear Information System (INIS)

    In this paper, the peristaltic flow of a Jeffrey fluid in an asymmetric rotating channel is studied. Mathematical modeling is carried out by utilizing long wavelength and low Reynolds number assumptions. Closed form expressions for the pressure gradient, pressure rise, streamlines, axial velocity and shear stress on the channel walls have been computed numerically. Effects of Hartmann number, the ratio of relaxation to retardation times, time-mean flow, rotation and the phase angle on the pressure gradient, pressure rise, streamline, axial velocity and shear stress are discussed in detail and shown graphically. The results indicate that the effect of the Hartmann number, the ratio of relaxation to retardation times, time-mean flow, rotation and the phase angle are very pronounced in the phenomena. Comparison was made with the results obtained in the asymmetric channel and symmetric channel. - Highlights: • The peristaltic flow of a Jeffrey fluid in an asymmetric rotating channel with magnetic field. • Mathematical modeling for long wavelength and low Reynolds number assumptions. • Closed form expressions for the pressure gradient, pressure rise, stream function, axial velocity and shear stress

  5. Williamson Fluid Model for the Peristaltic Flow of Chyme in Small Intestine

    Directory of Open Access Journals (Sweden)

    Sohail Nadeem

    2012-01-01

    Full Text Available Mathematical model for the peristaltic flow of chyme in small intestine along with inserted endoscope is considered. Here, chyme is treated as Williamson fluid, and the flow is considered between the annular region formed by two concentric tubes (i.e., outer tube as small intestine and inner tube as endoscope. Flow is induced by two sinusoidal peristaltic waves of different wave lengths, traveling down the intestinal wall with the same speed. The governing equations of Williamson fluid in cylindrical coordinates have been modeled. The resulting nonlinear momentum equations are simplified using long wavelength and low Reynolds number approximations. The resulting problem is solved using regular perturbation method in terms of a variant of Weissenberg number We. The numerical solution of the problem is also computed by using shooting method, and comparison of results of both solutions for velocity field is presented. The expressions for axial velocity, frictional force, pressure rise, stream function, and axial pressure gradient are obtained, and the effects of various emerging parameters on the flow characteristics are illustrated graphically. Furthermore, the streamlines pattern is plotted, and it is observed that trapping occurs, and the size of the trapped bolus varies with varying embedded flow parameters.

  6. Slip Effects on Peristaltic Transport of a Particle-Fluid Suspension in a Planar Channel

    Directory of Open Access Journals (Sweden)

    Mohammed H. Kamel

    2015-01-01

    Full Text Available Peristaltic pumping induced by a sinusoidal traveling wave in the walls of a two-dimensional channel filled with a viscous incompressible fluid mixed with rigid spherical particles is investigated theoretically taking the slip effect on the wall into account. A perturbation solution is obtained which satisfies the momentum equations for the case in which amplitude ratio (wave amplitude/channel half width is small. The analysis has been carried out by duly accounting for the nonlinear convective acceleration terms and the slip condition for the fluid part on the wavy wall. The governing equations are developed up to the second order of the amplitude ratio. The zeroth-order terms yield the Poiseuille flow and the first-order terms give the Orr-Sommerfeld equation. The results show that the slip conditions have significant effect within certain range of concentration. The phenomenon of reflux (the mean flow reversal is discussed under slip conditions. It is found that the critical reflux pressure is lower for the particle-fluid suspension than for the particle-free fluid and is affected by slip condition. A motivation of the present analysis has been the hope that such theory of two-phase flow process under slip condition is very useful in understanding the role of peristaltic muscular contraction in transporting biofluid behaving like a particle-fluid mixture. Also the theory is important to the engineering applications of pumping solid-fluid mixture by peristalsis.

  7. Peristaltic Transport of a Rheological Fluid: Model for Movement of Food Bolus Through Esophagus

    CERN Document Server

    Misra, J C

    2011-01-01

    Fluid mechanical peristaltic transport through esophagus has been of concern in the paper. A mathematical model has been developed with an aim to study the peristaltic transport of a rheological fluid for arbitrary wave shapes and tube lengths. The Ostwald-de Waele power law of viscous fluid is considered here to depict the non-Newtonian behaviour of the fluid. The model is formulated and analyzed with the specific aim of exploring some important information concerning the movement of food bolus through the esophagus. The analysis has been carried out by using lubrication theory. The study is particularly suitable for cases where the Reynolds number is small. The esophagus is treated as a circular tube through which the transport of food bolus takes places by periodic contraction of the esophageal wall. Variation of different variables concerned with the transport phenomena such as pressure, flow velocity, particle trajectory and reflux are investigated for a single wave as well as for a train of periodic per...

  8. A study of unsteady physiological magneto-fluid flow and heat transfer through a finite length channel by peristaltic pumping.

    Science.gov (United States)

    Tripathi, Dharmendra; Bég, O Anwar

    2012-08-01

    Magnetohydrodynamic peristaltic flows arise in controlled magnetic drug targeting, hybrid haemodynamic pumps and biomagnetic phenomena interacting with the human digestive system. Motivated by the objective of improving an understanding of the complex fluid dynamics in such flows, we consider in the present article the transient magneto-fluid flow and heat transfer through a finite length channel by peristaltic pumping. Reynolds number is small enough and the wavelength to diameter ratio is large enough to negate inertial effects. Analytical solutions for temperature field, axial velocity, transverse velocity, pressure gradient, local wall shear stress, volume flowrate and averaged volume flowrate are obtained. The effects of the transverse magnetic field, Grashof number and thermal conductivity on the flow patterns induced by peristaltic waves (sinusoidal propagation along the length of channel) are studied using graphical plots. The present study identifies that greater pressure is required to propel the magneto-fluid by peristaltic pumping in comparison to a non-conducting Newtonian fluid, whereas, a lower pressure is required if heat transfer is effective. The analytical solutions further provide an important benchmark for future numerical simulations. PMID:23057236

  9. Influence of magnetic field on peristaltic flow of a Casson fluid in an asymmetric channel: Application in crude oil refinement

    International Nuclear Information System (INIS)

    The influence of magnetic field on peristaltic flow of a Casson fluid model is considered. The model for peristaltic literature is modelled first time. The governing coupled equations are constructed under long wavelength and low Reynold's number approximation. Exact solutions are evaluated for stream function and pressure gradient. The important findings in this study are the variation of the Hartmann number M, Casson fluid parameter ζ and amplitudes a, b, d and ϕ. The velocity field increases due to increase in Hartmann number M near the channel walls while velocity field decreases at the centre of the channel. - Highlights: • The influence of magnetic field on peristaltic flow of a Casson fluid model is considered. • The model for peristaltic literature is modelled first time. • The governing coupled equations are constructed under long wavelength and low Reynold's number approximation. • Exact solutions are evaluated for stream function and pressure gradient. • The velocity field increases due to increase in Hartmann number M near the channel walls while velocity field decreases at the centre of the channel

  10. Investigation of a piezoelectric valveless micropump with an integrated stainless-steel diffuser/nozzle bulge-piece design

    Science.gov (United States)

    Tseng, Li-Yu; Yang, An-Shik; Lee, Chun-Ying; Cheng, Chiang-Ho

    2013-08-01

    To meet a growing need in biological and medical applications, innovative micro-electro-mechanical system (MEMS) technologies have realized important progress on the micropump as one of the essential fluid handling devices to deliver and control precise amounts of fluid flowing along a specific direction. This research proposes a piezoelectric (PZT) valveless micropump adopting an integrated diffuser/nozzle bulge-piece design. The pump mainly consisted of a stainless-steel structured chamber with dimensions of 8 mm in diameter and 70 μm in depth to enhance its long-term reliability, low-cost production, and maximized liquid compatibility. A PZT diaphragm was also used as a driving source to propel the liquid stream under actuation. As commonly used indices to describe pump operation, the delivered volumetric flow rates and pressures were determined at bulge-piece diameters of 2, 4 and 6 mm, with a driving voltage of 160 Vpp and frequency ranging from 50 to 550 Hz. Measurements and simulations have successfully shown that this micropump is capable of operating at a greater volumetric flow rate of up to 1.2 ml min-1 with a maximum back pressure of 5.3 kPa. In addition, the time-recurring flow behavior in the chamber and its relationship to the pumping performance were examined in detail.

  11. Investigation of a piezoelectric valveless micropump with an integrated stainless-steel diffuser/nozzle bulge-piece design

    International Nuclear Information System (INIS)

    To meet a growing need in biological and medical applications, innovative micro-electro-mechanical system (MEMS) technologies have realized important progress on the micropump as one of the essential fluid handling devices to deliver and control precise amounts of fluid flowing along a specific direction. This research proposes a piezoelectric (PZT) valveless micropump adopting an integrated diffuser/nozzle bulge-piece design. The pump mainly consisted of a stainless-steel structured chamber with dimensions of 8 mm in diameter and 70 μm in depth to enhance its long-term reliability, low-cost production, and maximized liquid compatibility. A PZT diaphragm was also used as a driving source to propel the liquid stream under actuation. As commonly used indices to describe pump operation, the delivered volumetric flow rates and pressures were determined at bulge-piece diameters of 2, 4 and 6 mm, with a driving voltage of 160 Vpp and frequency ranging from 50 to 550 Hz. Measurements and simulations have successfully shown that this micropump is capable of operating at a greater volumetric flow rate of up to 1.2 ml min−1 with a maximum back pressure of 5.3 kPa. In addition, the time-recurring flow behavior in the chamber and its relationship to the pumping performance were examined in detail. (paper)

  12. A Mathematical Model for Peristaltic Transport of Micro-Polar Fluids

    Directory of Open Access Journals (Sweden)

    S. K. Pandey

    2011-01-01

    Full Text Available A mathematical model has been constructed for peristaltic transport of micro-polar fluid in a circular cylindrical tube of finite length by letting sinusoidal waves propagate along the wall that induce contraction and relaxation but not expansion beyond the natural boundary. Axial and radial velocities and micro-rotation components are formulated for micro-polar fluid transportations by applying the method of long wavelength and low Reynolds number approximations in the analysis. Pressure distribution along the tube length is studied to investigate temporal effects. An in-depth study has been done to learn the effects of coupling number and micro-polar parameter. The effects of coupling number and micro-polar parameter are investigated also on mechanical efficiency, reflux and trapping. A significant difference observed is that unlike integral wave-trains propagating along the tube walls that have identical peaks of pressure, non-integral wave-trains have peaks of different sizes.

  13. Simulations of peristaltic slip-flow of hydromagnetic bio-fluid in a curved channel

    Directory of Open Access Journals (Sweden)

    N. Ali

    2016-02-01

    Full Text Available The influence of slip and magnetic field on transport characteristics of a bio-fluid are analyzed in a curved channel. The problem is modeled in curvilinear coordinate system under the assumption that the wavelength of the peristaltic wave is larger in magnitude compared to the width of the channel. The resulting nonlinear boundary value problem (BVP is solved using an implicit finite difference technique (FDT. The flow velocity, pressure rise per wavelength and stream function are illustrated through graphs for various values of rheological and geometrical parameters of the problem. The study reveals that a thin boundary layer exists at the channel wall for strong magnetic field. Moreover, small values of Weissenberg number counteract the curvature and make the velocity profile symmetric. It is also observed that pressure rise per wavelength in pumping region increases (decreases by increasing magnetic field, Weissenberg number and curvature of the channel (slip parameter.

  14. A peristaltic micro pump driven by a rotating motor with magnetically attracted steel balls.

    Science.gov (United States)

    Du, Min; Ye, Xiongying; Wu, Kang; Zhou, Zhaoying

    2009-01-01

    In this paper, we present a membrane peristaltic micro pump driven by a rotating motor with magnetically attracted steel balls for lab-on-a-chip applications. The fabrication process is based on standard soft lithography technology and bonding of a PDMS layer with a PMMA substrate. A linear flow rate range ∼490 μL/min was obtained by simply varying the rotation speed of a DC motor, and a maximum back pressure of 592 Pa was achieved at a rotation speed of 43 rpm. The flow rate of the pump can also be adjusted by using steel balls with different diameters or changing the number of balls. Nevertheless, the micro pump can also work in high speed mode. A high back pressure up to 10 kPa was achieved at 500 rpm using a high speed DC motor, and an utmost flow rate up to 5 mL/min was reached. PMID:22574035

  15. Simulations of peristaltic slip-flow of hydromagnetic bio-fluid in a curved channel

    Science.gov (United States)

    Ali, N.; Javid, K.; Sajid, M.

    2016-02-01

    The influence of slip and magnetic field on transport characteristics of a bio-fluid are analyzed in a curved channel. The problem is modeled in curvilinear coordinate system under the assumption that the wavelength of the peristaltic wave is larger in magnitude compared to the width of the channel. The resulting nonlinear boundary value problem (BVP) is solved using an implicit finite difference technique (FDT). The flow velocity, pressure rise per wavelength and stream function are illustrated through graphs for various values of rheological and geometrical parameters of the problem. The study reveals that a thin boundary layer exists at the channel wall for strong magnetic field. Moreover, small values of Weissenberg number counteract the curvature and make the velocity profile symmetric. It is also observed that pressure rise per wavelength in pumping region increases (decreases) by increasing magnetic field, Weissenberg number and curvature of the channel (slip parameter).

  16. Effect of induced magnetic field on peristaltic flow of a micropolar fluid in an asymmetric channel

    CERN Document Server

    Shit, G C; Ng, E Y K; 10.1002/cnm.1397

    2010-01-01

    Of concern in this paper is an investigation of peristaltic transport of a physiological fluid in an asymmetric channel under long wave length and low-Reynolds number assumptions. The flow is assumed to be incompressible, viscous, electrically conducting micropolar fluid and the effect of induced magnetic field is taken into account. Exact analytical solutions obtained for the axial velocity, microrotation component, stream line pattern, magnetic force function, axial-induced magnetic field as well as the current density distribution across the channel. The flow phenomena for the pumping characteristics, trapping and reflux are also investigated. The results presented reveal that the velocity decreases with the increase of magnetic field as well as the coupling parameter. Moreover, the trapping fluid can be eliminated by the application of an external magnetic field. Thus, the study bears the promise of important applications in physiological systems.

  17. Convective boundary conditions effect on peristaltic flow of a MHD Jeffery nanofluid

    Science.gov (United States)

    Kothandapani, M.; Prakash, J.

    2016-03-01

    This work is aimed at describing the influences of MHD, chemical reaction, thermal radiation and heat source/sink parameter on peristaltic flow of Jeffery nanofluids in a tapered asymmetric channel along with slip and convective boundary conditions. The governing equations of a nanofluid are first formulated and then simplified under long-wavelength and low-Reynolds number approaches. The equation of nanoparticles temperature and concentration is coupled; hence, homotopy perturbation method has been used to obtain the solutions of temperature and concentration of nanoparticles. Analytical solutions for axial velocity, stream function and pressure gradient have also constructed. Effects of various influential flow parameters have been pointed out through with help of the graphs. Analysis indicates that the temperature of nanofluids decreases for a given increase in heat transfer Biot number and chemical reaction parameter, but it possesses converse behavior in respect of mass transfer Biot number and heat source/sink parameter.

  18. Non-Newtonian effects in the peristaltic flow of a Maxwell fluid

    CERN Document Server

    Tsiklauri, D

    2001-01-01

    We analyzed the effect of viscoelasticity on the dynamics of fluids in porous media by studying the flow of a Maxwell fluid in a circular tube, in which the flow is induced by a wave traveling on the tube wall. The present study investigates novelties brought about into the classic peristaltic mechanism by inclusion of non-Newtonian effects that are important, for example, for hydrocarbons. This problem has numerous applications in various branches of science, including stimulation of fluid flow in porous media under the effect of elastic waves. We have found that in the extreme non-Newtonian regime there is a possibility of a fluid flow in the direction {\\it opposite} to the propagation of the wave traveling on the tube wall.

  19. Peristaltic motion of Johnson-Segalman fluid in a curved channel with slip conditions.

    Directory of Open Access Journals (Sweden)

    Sadia Hina

    Full Text Available Slip effects on the peristaltic transport of Johnson-Segalman fluid through a curved channel have been addressed. The influence of wall properties is also analyzed. Long wavelength and low Reynolds number assumptions have been utilized in the mathematical formulation of the problem. The equations so formed have been solved numerically by shooting method through computational software Mathematica 8. In addition the analytic solution for small Weissenberg number (elastic parameter is computed through a regular perturbation method. An excellent agreement is noticed between the two solutions. The results indicate an increase in the magnitude of velocity with an intensification in the slip effect. Moreover the size and circulation of the trapped boluses increase with an increase in the slip parameter. Unlike the planar channel, the profiles of axial velocity are not symmetric about the central line of the channel.

  20. Simultaneous effects of slip and wall properties on MHD peristaltic motion of nanofluid with Joule heating

    Energy Technology Data Exchange (ETDEWEB)

    Hayat, T. [Department of Mathematics, Quaid-I-Azam University 45320, Islamabad 44000 (Pakistan); Nonlinear Analysis and Applied Mathematics (NAAM) Research Group, Department of Mathematics, King Abdulaziz University, P.O. Box 80257, Jeddah 21589 (Saudi Arabia); Nisar, Z. [Department of Mathematics, Quaid-I-Azam University 45320, Islamabad 44000 (Pakistan); Ahmad, B. [Nonlinear Analysis and Applied Mathematics (NAAM) Research Group, Department of Mathematics, King Abdulaziz University, P.O. Box 80257, Jeddah 21589 (Saudi Arabia); Yasmin, H., E-mail: qau2011@gmail.com [Department of Mathematics, COMSATS Institute of Information Technology, G.T. Road, Wah Cantt 47040 (Pakistan)

    2015-12-01

    This paper is devoted to the magnetohydrodynamic (MHD) peristaltic transport of nanofluid in a channel with wall properties. Flow analysis is addressed in the presence of viscous dissipation, partial slip and Joule heating effects. Mathematical modelling also includes the salient features of Brownian motion and thermophoresis. Both analytic and numerical solutions are provided. Comparison between the solutions is shown in a very good agreement. Attention is focused to the Brownian motion parameter, thermophoresis parameter, Hartman number, Eckert number and Prandtl number. Influences of various parameters on skin friction coefficient, Nusselt and Sherwood numbers are also investigated. It is found that both the temperature and nanoparticles concentration are increasing functions of Brownian motion and thermophoresis parameters. - Highlights: • Temperature rises when Brownian motion and thermophoresis effects intensify. • Temperature profile increases when thermal slip parameter increases. • Concentration field is a decreasing function of concentration slip parameter. • Temperature decreases whereas concentration increases for Hartman number.

  1. Peristaltic Transport of Prandtl-Eyring Liquid in a Convectively Heated Curved Channel.

    Science.gov (United States)

    Hayat, Tasawar; Bibi, Shahida; Alsaadi, Fuad; Rafiq, Maimona

    2016-01-01

    Here peristaltic activity for flow of a Prandtl-Eyring material is modeled and analyzed for curved geometry. Heat transfer analysis is studied using more generalized convective conditions. The channel walls satisfy complaint walls properties. Viscous dissipation in the thermal equation accounted. Unlike the previous studies is for uniform magnetic field on this topic, the radial applied magnetic field has been utilized in the problems development. Solutions for stream function (ψ), velocity (u), and temperature (θ) for small parameter β have been derived. The salient features of heat transfer coefficient Z and trapping are also discussed for various parameters of interest including magnetic field, curvature, material parameters of fluid, Brinkman, Biot and compliant wall properties. Main observations of present communication have been included in the conclusion section. PMID:27304458

  2. Mixed Convective Peristaltic Flow of Water Based Nanofluids with Joule Heating and Convective Boundary Conditions.

    Science.gov (United States)

    Hayat, Tasawar; Nawaz, Sadaf; Alsaedi, Ahmed; Rafiq, Maimona

    2016-01-01

    Main objective of present study is to analyze the mixed convective peristaltic transport of water based nanofluids using five different nanoparticles i.e. (Al2O3, CuO, Cu, Ag and TiO2). Two thermal conductivity models namely the Maxwell's and Hamilton-Crosser's are used in this study. Hall and Joule heating effects are also given consideration. Convection boundary conditions are employed. Furthermore, viscous dissipation and heat generation/absorption are used to model the energy equation. Problem is simplified by employing lubrication approach. System of equations are solved numerically. Influence of pertinent parameters on the velocity and temperature are discussed. Also the heat transfer rate at the wall is observed for considered five nanofluids using the two phase models via graphs. PMID:27104596

  3. Simultaneous effects of slip and wall properties on MHD peristaltic motion of nanofluid with Joule heating

    International Nuclear Information System (INIS)

    This paper is devoted to the magnetohydrodynamic (MHD) peristaltic transport of nanofluid in a channel with wall properties. Flow analysis is addressed in the presence of viscous dissipation, partial slip and Joule heating effects. Mathematical modelling also includes the salient features of Brownian motion and thermophoresis. Both analytic and numerical solutions are provided. Comparison between the solutions is shown in a very good agreement. Attention is focused to the Brownian motion parameter, thermophoresis parameter, Hartman number, Eckert number and Prandtl number. Influences of various parameters on skin friction coefficient, Nusselt and Sherwood numbers are also investigated. It is found that both the temperature and nanoparticles concentration are increasing functions of Brownian motion and thermophoresis parameters. - Highlights: • Temperature rises when Brownian motion and thermophoresis effects intensify. • Temperature profile increases when thermal slip parameter increases. • Concentration field is a decreasing function of concentration slip parameter. • Temperature decreases whereas concentration increases for Hartman number

  4. Peristaltic Pumping near Post-CME Supra-Arcade Current Sheets

    CERN Document Server

    Scott, Roger B; McKenzie, David E

    2013-01-01

    Measurements of temperature and density near supra-arcade current sheets suggest that plasma on unreconnected field lines may experience some degree of "pre-heating" and "pre-densification" prior to their reconnection. Models of patchy reconnection allow for heating and acceleration of plasma along reconnected field lines but do not offer a mechanism for transport of thermal energy across field lines. Here we present a model in which a reconnected flux tube retracts, deforming the surrounding layer of unreconnected field. The deformation creates constrictions that act as peristaltic pumps, driving plasma flow along affected field lines. Under certain circumstances these flows lead to shocks that can extend far out into the unreconnected field, altering the plasma properties in the affected region. These findings have direct implications for observations in the solar corona, particularly in regard to such phenomena as high temperatures near current sheets in eruptive solar flares and wakes seen in the form of ...

  5. A Peristaltic Micro Pump Driven by a Rotating Motor with Magnetically Attracted Steel Balls

    Directory of Open Access Journals (Sweden)

    Zhaoying Zhou

    2009-04-01

    Full Text Available In this paper, we present a membrane peristaltic micro pump driven by a rotating motor with magnetically attracted steel balls for lab-on-a-chip applications. The fabrication process is based on standard soft lithography technology and bonding of a PDMS layer with a PMMA substrate. A linear flow rate range ~490 μL/min was obtained by simply varying the rotation speed of a DC motor, and a maximum back pressure of 592 Pa was achieved at a rotation speed of 43 rpm. The flow rate of the pump can also be adjusted by using steel balls with different diameters or changing the number of balls. Nevertheless, the micro pump can also work in high speed mode. A high back pressure up to 10 kPa was achieved at 500 rpm using a high speed DC motor, and an utmost flow rate up to 5 mL/min was reached.

  6. Dry actuation testing of viscous drag micropumping systems for determination of optimal drive waveforms

    Science.gov (United States)

    Sosnowchik, Brian D.; Galambos, Paul C.; Sharp, Kendra V.; Jenkins, Mark W.; Horn, Mark W.; Hendrix, Jason R.

    2004-01-01

    This paper presents the dry actuation testing procedures and results for novel viscous drag micropumping systems. To overcome the limitations of previously developed mechanical pumps, we have developed pumps that are surface micromachined for efficient mass production which utilize viscous drag (dominant at low Reynolds numbers typical of microfluidics) to move fluid. The SUMMiT (www.sandia.gov/micromachine) fabricated pumps, presented first by Kilani et al., are being experimentally and computationally analyzed. In this paper we will describe the development of optimal waveforms to drive the electrostatic pumping mechanism while dry. While wet actuation will be significantly different, dry testing provides insight into how to optimally move the mechanism and differences between dry and wet actuation can be used to isolate fluid effects. Characterization began with an analysis of the driving voltage waveforms for the torsional ratcheting actuator (TRA), a micro-motor that drove the gear transmission for the pump, actuated with SAMA (Sandia"s Arbitrary waveform MEMS Actuator), a new waveform generating computer program with the ability to generate and output arbitrary voltage signals. Based upon previous research, a 50% duty cycle half-sine wave was initially selected for actuation of the TRA. However, due to the geometry of the half-sine waveform, the loaded micromotor could not transmit the motion required to pump the tested liquids. Six waveforms were then conceived, constructed, and selected for device actuation testing. Dry actuation tests included high voltage, low voltage, high frequency, and endurance/reliability testing of the TRA, gear transmission and pump assembly. In the SUMMiT process, all of the components of the system are fabricated together on one silicon chip already assembled in a monolithic microfabrication process. A 40% duty cycle quarter-sine waveform with a 20% DC at 60V has currently proved to be the most reliable, allowing for an 825Hz

  7. 微量注射泵的质量检测及误差探究%Quality Inspection and Error Inquiry of the Injection Micro-pump

    Institute of Scientific and Technical Information of China (English)

    杨康为; 胡世辉; 龚婷婷

    2016-01-01

    通过对不同型号的微量注射泵进行质量控制检测,研究它们的瞬时流速、平均流速的相对误差和绝对误差,以期为日后质量控制工作的开展提供些许帮助,为临床在注射泵上的使用提供安全保障。%The research explores the relative and absolute error under the instantaneous velocity and the average velocity based on the quality control testing of different models of injection micro-pump. The research aims to help with the process of quality control of the injection micro-pump so as to enhance the reliability of the injection micro-pump in clinical practice.

  8. 微量注射泵的质量检测及误差探究%Quality Inspection and Error Inquiry of the Injection Micro-pump

    Institute of Scientific and Technical Information of China (English)

    杨康为; 胡世辉; 龚婷婷

    2016-01-01

    The research explores the relative and absolute error under the instantaneous velocity and the average velocity based on the quality control testing of different models of injection micro-pump. The research aims to help with the process of quality control of the injection micro-pump so as to enhance the reliability of the injection micro-pump in clinical practice.%通过对不同型号的微量注射泵进行质量控制检测,研究它们的瞬时流速、平均流速的相对误差和绝对误差,以期为日后质量控制工作的开展提供些许帮助,为临床在注射泵上的使用提供安全保障。

  9. Multi-Phase Flow and Heat Transfer of a Micro-Pump Thermally Driven by a Multi-Output Pulse Laser

    Institute of Scientific and Technical Information of China (English)

    HUAI Xiu-Lan; TANG Zhi-Wei; WANG Guo-Xiang; WANG Wei-Wei

    2005-01-01

    @@ We present an experimental study of multi-phase flow and heat transfer in a micro-tube induced by a multi-output pulse laser. Extensive flow and heat transfer measurements and visualization experiments have been carried out to characterize the micro-pump behaviour under various conditions. The experiments reveal extremely unsteady and complex flow patterns in the micro tube with the flow closely related with generation and collapse of bubbles.It is found that the flow rates are controlled by the heating and condensation conditions within the tube. The laser pulse duration, pulse interval and output-power as well as the tube diameter all show a strong influence on the flow rate of the micro-pump. This study provides a basis for the design of thermally-driven micro-pump induced by a pulsed laser beam.

  10. A new working principle for ac electro-hydrodynamic on-chip micro-pumps

    International Nuclear Information System (INIS)

    Our new type of on-chip micro-pump exploits the ac electro-kinetic forces acting in the volume of a fluid in the presence of a temperature gradient. No mechanically movable parts are used. The velocity of the pump flow observed depends on the frequency and strength of the driving ac field and on the temperature gradient across the pump channel. An integrated heating element allows the temperature gradient to be adjusted. Both ac field electrodes and heating element are platinum structures processed on a glass chip. The pump-channel walls and cover are made from polymer and thin-glass, respectively. In this paper, we present measurements of the fluid velocity as functions of the medium conductivity (0.1-1.3 S m-1) and field frequency (300 kHz-52 MHz), voltage across the field-electrode voltage (0-35 Vrms) and the heating element (1.1-3.6 V). Velocities of up to 120 μm s-1 were observed in the pump channel. The advantage of our new design is an evenly shaped cross-section of the pump channel, which reduces the risk of the channel becoming clogged by debris. Ac-electro-osmosis is not a predominant effect in our structures. Pumping could only be observed when the heating current and ac-pump field were applied simultaneously. The effects observed were simulated with the COMSOL Multiphysics program

  11. Development and Application of a Diaphragm Micro-Pump with Piezoelectric Device

    CERN Document Server

    Ma, H K; Wu, H Y; Lin, C Y; Gao, J J; Kou, M C

    2008-01-01

    In this study, a new type of thin, compact, and light weighed diaphragm micro-pump has been successfully developed to actuate the liquid by the vibration of a diaphragm. The micro-diaphragm pump with two valves is fabricated in an aluminum case by using highly accurate CNC machine, and the cross-section dimension is 5mm x 8mm. Both valves and diaphragm are manufactured from PDMS. The amplitude of vibration by a piezoelectric device produces an oscillating flow which may change the chamber volume by changing the curvature of a diaphragm. Several experimental set-ups for performance test in a single micro-diaphragm pump, isothermal flow open system, and a closed liquid cooling system is designed and implemented. The performance of one-side actuating micro-diaphragm pump is affected by the design of check valves, diaphragm, piezoelectric device, chamber volume, input voltage and frequency. The measured maximum flow rate of present design is 72 ml/min at zero total pump head in the range of operation frequency 70...

  12. The Structure of Wheel Check Valve Influence on Air Block Phenomenon of Piezoelectric Micro-Pump

    Directory of Open Access Journals (Sweden)

    Song Chen

    2015-11-01

    Full Text Available To improve the stability and reliability of the piezoelectric micro-pump, the cause of air block phenomenon is analyzed on the structure of wheel check valve. During the movement of the bubble in the micro-channel, pressure drop occurs, the main factor which influences the bubble going through is opening height of the wheel check valve. Five groups of wheel check valves with different structures are used to test the wheel check valve opening height and air block probability. The experiment results show that reducing the wheel check valve thickness or diameter ratio can both increase the wheel check valve opening height, and decrease the air block probability. Through experiment, the optimum combination of the wheel check valve structure is obtained within the samples: as the thickness is 0.02 mm, the diameter ratio is 1.2, the wheel check valve opening height gets 252 µm, and within the given bubble volume, the air block probability is less than 2%.

  13. A MEMS-based silicon micropump with intersecting channels and integrated hotwires

    International Nuclear Information System (INIS)

    This paper presents the development of a gas-jet micropump with different cross-junctions and integrated hotwire. The device is actuated by a piezoelectric lead zirconate titanate (PZT) diaphragm at its resonant frequency. The design focuses on a cross-junction formed by the intersection of the channels and neck of the pump chamber, which allows differences in fluidic resistance and fluidic momentum during each PZT diaphragm vibration cycle and thus enables rectification of the gas without valves. Three different designs were investigated by utilizing the ANSYS-FLUENT software. Simulations and experimental data revealed that the step nozzle structure with anti-choking space has much more advantages than the others. The device has been fabricated by the standard MEMS process, and the tiny hotwire has been realized together with the fluidic network. Experiments have been carried out. At a driven frequency of 7.9 kHz, a flow rate of 5.2 ml min−1 was obtained with an applied sinusoidal voltage of 50 Vp-p. The output voltage on the hotwire was measured to be 130 mV at a constant current of I = 0.1 mA

  14. A MEMS-based silicon micropump with intersecting channels and integrated hotwires

    Science.gov (United States)

    Thanh Dau, Van; Dinh, Thien Xuan; Sugiyama, Susumu

    2009-12-01

    This paper presents the development of a gas-jet micropump with different cross-junctions and integrated hotwire. The device is actuated by a piezoelectric lead zirconate titanate (PZT) diaphragm at its resonant frequency. The design focuses on a cross-junction formed by the intersection of the channels and neck of the pump chamber, which allows differences in fluidic resistance and fluidic momentum during each PZT diaphragm vibration cycle and thus enables rectification of the gas without valves. Three different designs were investigated by utilizing the ANSYS-FLUENT software. Simulations and experimental data revealed that the step nozzle structure with anti-choking space has much more advantages than the others. The device has been fabricated by the standard MEMS process, and the tiny hotwire has been realized together with the fluidic network. Experiments have been carried out. At a driven frequency of 7.9 kHz, a flow rate of 5.2 ml min-1 was obtained with an applied sinusoidal voltage of 50 Vp-p. The output voltage on the hotwire was measured to be 130 mV at a constant current of I = 0.1 mA.

  15. PV-Li-ion-micropump membrane systems for portable personal desalination

    Directory of Open Access Journals (Sweden)

    Mark P. McHenry

    2016-03-01

    Full Text Available This research presents a technical simulation of theoretically portable desalination systems utilising low-energy and lightweight components that are either commercially available or currently in development. The commercially available components are small-scale flexible and portable photovoltaic (PV modules, Li-ion battery-converter units, and high pressure low voltage brushless DC motor-powered micropumps. The theoretical and conventional small-scale desalination membranes are compared against each other: low-pressure reverse osmosis (RO, nanofilters, graphene, graphene oxide, and graphyne technology. The systems were designed with the identical PV-Li-ion specifications and simulation data to quantify the energy available to power the theoretical energy demand for desalinating a saline water at 30,000–40,000 ppm total dissolved solid (TDS to reliably supply the minimum target of 3.5 L d−1 of freshwater for one theoretical year. The results demonstrate that modern portable commercially available PV-battery systems and new generations of energy-efficient membranes under development have the potential to enable users to sustainably procure daily drinking water needs from saline/contaminated water resources, with the system exhibiting a net reduction in weight than carrying water itself.

  16. Insulin Micropump with Embedded Pressure Sensors for Failure Detection and Delivery of Accurate Monitoring

    Directory of Open Access Journals (Sweden)

    Dimitry Dumont-Fillon

    2014-11-01

    Full Text Available Improved glycemic control with insulin pump therapy in patients with type 1 diabetes mellitus has shown gradual reductions in nephropathy and retinopathy. More recently, the emerging concept of the artificial pancreas, comprising an insulin pump coupled to a continuous glucose meter and a control algorithm, would become the next major breakthrough in diabetes care. The patient safety and the efficiency of the therapy are directly derived from the delivery accuracy of rapid-acting insulin. For this purpose, a specific precision-oriented design of micropump has been built. The device, made of a stack of three silicon wafers, comprises two check valves and a pumping membrane that is actuated against stop limiters by a piezo actuator. Two membranes comprising piezoresistive strain gauges have been implemented to measure the pressure in the pumping chamber and at the outlet of the pump. Their high sensitivity makes possible the monitoring of the pumping accuracy with a tolerance of ±5% for each individual stroke of 200 nL. The capability of these sensors to monitor priming, reservoir overpressure, reservoir emptying, outlet occlusion and valve leakage has also been studied.

  17. Numerical analysis of thermal creep flow in curved channels for designing a prototype of Knudsen micropump

    International Nuclear Information System (INIS)

    The possibility to generate a gas flow inside a channel just by imposing a tangential temperature gradient along the walls without the existence of an initial pressure difference is well known. The gas must be under rarefied conditions, meaning that the system must operate between the slip and the free molecular flow regimes, either at low pressure or/and at micro/nano-scale dimensions. This phenomenon is at the basis of the operation principle of Knudsen pumps, which are actually compressors without any moving parts. Nowadays, gas flows in the slip flow regime through microchannels can be modeled using commercial Computational Fluid Dynamics softwares, because in this regime the compressible Navier-Stokes equations with appropriate boundary conditions are still valid. A simulation procedure has been developed for the modeling of thermal creep flow using ANSYS Fluent®. The implementation of the boundary conditions is achieved by developing User Defined Functions (UDFs) by means of C++ routines. The complete first order velocity slip boundary condition, including the thermal creep effects due to the axial temperature gradient and the effect of the wall curvature, and the temperature jump boundary condition are applied. The developed simulation tool is used for the preliminary design of Knudsen micropumps consisting of a sequence of curved and straight channels.

  18. Wireless programmable electrochemical drug delivery micropump with fully integrated electrochemical dosing sensors.

    Science.gov (United States)

    Sheybani, Roya; Cobo, Angelica; Meng, Ellis

    2015-08-01

    We present a fully integrated implantable electrolysis-based micropump with incorporated EI dosing sensors. Wireless powering and data telemetry (through amplitude and frequency modulation) were utilized to achieve variable flow control and a bi-directional data link with the sensors. Wireless infusion rate control (0.14-1.04 μL/min) and dose sensing (bolus resolution of 0.55-2 μL) were each calibrated separately with the final circuit architecture and then simultaneous wireless flow control and dose sensing were demonstrated. Recombination detection using the dosing system, as well as, effects of coil separation distance and misalignment in wireless power and data transfer were studied. A custom-made normally closed spring-loaded ball check valve was designed and incorporated at the reservoir outlet to prevent backflow of fluids as a result of the reverse pressure gradient caused by recombination of electrolysis gases. Successful delivery, infusion rate control, and dose sensing were achieved in simulated brain tissue. PMID:26149696

  19. Design and fabrication of a screw-driven multi-channel peristaltic pump for portable microfluidic devices

    International Nuclear Information System (INIS)

    A novel peristaltic pump for portable microfluidic devices has been recently designed and fabricated. The operation principle is based on the peristaltic motion of eight elastic pumping channels that are occluded by a screw shaft. The screw shaft rotating inside the pumping channel unit has a spirally arranged projection which deforms and closes down the channels as a normally closed valve. While the shaft rotates, the pinched locations in the channels move either way according to the direction of rotation, squeezing out the fluid inside. It features unlimited and quantitative fluid feeding with a wide range of flow rates for one channel from 3.5 µL min−1 at 3 rpm to 280.2 µL min−1 at 180 rpm. It was demonstrated that pulsation can be drastically reduced by merging two anti-phase channels.

  20. Effects of heat transfer on peristaltic motion of Oldroyd fluid in the presence of inclined magnetic field

    International Nuclear Information System (INIS)

    In this study the peristaltic motion of Oldroyd fluid in an asymmetric channel is investigated. Mathematical analysis has been carried out in the presence of an inclined magnetic field. Heat transfer is also taken into account. The physical problem is first modeled and then the analytical solutions of coupled equations are developed by regular perturbation method. Assumptions of long wavelength approximation are used. Effects of inclined magnetic field on the axial velocity and temperature are presented. Physical features of pertinent parameters such as wave number δ, Reynolds number Re, Weissenberg number Wi, Prandtl number Pr and Hartmann number M are also discussed graphically at the end of the paper. - Highlights: • This paper analyses heat transfer and inclined magnetic effects in peristaltic motion of Oldroyd fluid. • An asymmetric channel under long wavelength approximation is considered. • Regular perturbation method is used to find analytical solutions. • Effects of sundry parameters are presented through graphs

  1. Consequence of nanofluid on peristaltic transport of a hyperbolic tangent fluid model in the occurrence of apt (tending) magnetic field

    International Nuclear Information System (INIS)

    In the current study, sway of nanofluid on peristaltic transport of a hyperbolic tangent fluid model in the incidence of tending magnetic field has been argued. The governing equations of a nanofluid are first modeled and then simplified under lubrication approach. The coupled nonlinear equations of temperature and nano particle volume fraction are solved analytically using a homotopy perturbation technique. The analytical solution of the stream function and pressure gradient are carried out using perturbation technique. The graphical results of the problem under discussion are also being brought under consideration to see the behavior of various physical parameters. - Highlights: • The main motivation of this work is that we want to see the behavior of nanofluids in peristaltic flows. • In literature few articles are available on this, but no article is available in asymmetric channel on the new fluid model hyperbolic tangent fluid. • So we want to fill the gap in literature studying this

  2. An analytical and numerical study of peristaltic transport of a Johnson—Segalman fluid in an endoscope

    International Nuclear Information System (INIS)

    In the present study, we discuss the peristaltic flow of a Johnson—Segalman fluid in an endoscope. Perturbation, homotopy, and numerical solutions are found for the non-linear differential equation. The comparative study is also made to check the validity of the solutions. The expressions for pressure rise frictional forces, pressure gradient, and stream lines are presented to interpret the behavior of various physical quantities of the Johnson—Segalman fluid. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  3. Peristaltic Transport of a Physiological Fluid in an Asymmetric Porous Channel in the Presence of an External Magnetic Field

    OpenAIRE

    Misra, J. C.; Maiti, S.; Shit, G. C.

    2010-01-01

    The paper deals with a theoretical investigation of the peristaltic transport of a physiological fluid in a porous asymmetric channel under the action of a magnetic field. The stream function, pressure gradient and axial velocity are studied by using appropriate analytical and numerical techniques. Effects of different physical parameters such as permeability, phase difference, wave amplitude and magnetic parameter on the velocity, pumping characteristics, streamline pattern and trapping are ...

  4. Effect of slip on heat transfer to peristaltic transport in the presence of magnetic field with wall effects

    OpenAIRE

    A. V. Ramana Kumari; G. Radhakrishnamacharya

    2011-01-01

    The effects of slip and elasticity of flexible walls on peristaltic transport of an incompressible viscous fluid in a two dimensional uniform channel, with heat transfer in the presence of magnetic field is investigated. Using long wavelength approximation, a perturbation solution has been obtained in terms of wall slope parameter and closed form expressions are derived for average velocity, temperature and heat transfer. The effects of various pertinent parameters on average velocity and hea...

  5. Simultaneous effects of Hall and convective conditions on peristaltic flow of couple-stress fluid in an inclined asymmetric channel

    Indian Academy of Sciences (India)

    T Hayat; Maryam Iqbal; Humaira Yasmin; Fuad E Alsaadi; Huijun Gao

    2015-07-01

    A mathematical model is developed to analyse the peristaltic flow of couple-stress fluid in an inclined asymmetric channel with convective conditions. Soret and Dufour and Hall effects are taken into account. Analysis has been carried out in a wave frame of reference. Expressions for velocity, pressure gradient, temperature and concentration are constructed. Pumping and trapping phenomena are examined. Impact of sundry parameters on the velocity, temperature and concentration is discussed.

  6. Transient magneto-peristaltic flow of couple stress biofluids: a magneto-hydro-dynamical study on digestive transport phenomena.

    Science.gov (United States)

    Tripathi, Dharmendra; Anwar Bég, O

    2013-11-01

    Magnetic fields are increasingly being utilized in endoscopy and gastric transport control. In this regard, the present study investigates the influence of a transverse magnetic field in the transient peristaltic rheological transport. An electrically-conducting couple stress non-Newtonian model is employed to accurately simulate physiological fluids in peristaltic flow through a sinusoidally contracting channel of finite length. This model is designed for computing the intra-bolus oesophageal and intestinal pressures during the movement of food bolus in the digestive system under magneto-hydro-dynamic effects. Long wavelength and low Reynolds number approximations have been employed to reduce the governing equations from nonlinear to linear form, this being a valid approach for creeping flows which characterizes physiological dynamics. Analytical approximate solutions for axial velocity, transverse velocity, pressure gradient, local wall shear stress and volumetric flow rate are obtained for the non-dimensional conservation equations subject to appropriate boundary conditions. The effects of couple stress parameter and transverse magnetic field on the velocity profile, pressure distribution, local wall shear stress and the averaged flow rate are discussed with the aid of computational results. The comparative study of non-integral and integral number of waves propagating along the finite length channel is also presented. Magnetic field and non-Newtonian properties are found to strongly influence peristaltic transport. PMID:23911695

  7. Peristaltic flow of a Jeffrey fluid under the effect of radially varying magnetic field in a tube with an endoscope

    International Nuclear Information System (INIS)

    The influence of an endoscope on peristaltic flow of a Jeffrey fluid through the cylindrical cavity between concentric tubes with variable magnetic field has been investigated. The governing equations of two dimensional fluid have been simplified under the consideration of long wavelength and low Reynolds number approximation. Exact analytical calculations are carried out for the pressure gradient, velocity, pressure rise, friction force on the inner and outer tubes and shear stress. The effect of the non-dimensional wave amplitude, the variable magnetic field, the ratio of relaxation of retardation time, the radius ratio and the non-dimensional volume flow are analyzed theoretically and computed numerically. Comparison was made with the results obtained in the presence and absence of variable magnetic field and an endoscope. The results indicate that the effect of the non-dimensional wave amplitude, variable magnetic field, ratio of relaxation to retardation time, radius ratio and non-dimensional volume flow on peristaltic flow are very pronounced. - Highlights: • The peristaltic flow of a Jeffrey fluid through the cylindrical cavity between concentric tubes with variable magnetic field. • Mathematical modeling is carried out by utilizing long wavelength and low Reynolds number assumptions. • Closed form expressions for the entered parameters have been computed numerically

  8. ZnO film based surface acoustic wave micro-pump

    International Nuclear Information System (INIS)

    In this study, a micro-pump unit based on surface acoustic wave (SAW) on piezoelectric ZnO film is designed and fabricated as a micro-fluidic device. It employs a mechanical wave, which is generated electrically using an aluminum interdigital transducer (IDT), and propagates on the surface of the ZnO film. The ZnO film was used in this study because it has a high electromechanical coefficient and an excellent bonding with various substrate materials, in particular silicon. The sputtering parameters for ZnO film deposition have been optimized, and the ZnO films with different thickness from 1 micron to 5.5 microns were prepared. The film properties have been characterized using different methods, such as scanning electron microscopy, X-ray diffraction and atomic force microscopy. Aluminum IDT with a finger width and spacing of 8 microns was patterned on the ZnO film using a lift-off process. The frequency generated was measured using a network analyzer, and it varies from 130 MHz to 180 MHz as a function of film thickness. A signal generator was used to generate the frequency with a power amplifier to amplify the signal, which was then applied to aluminum IDT to generate the surface acoustic wave. If a liquid droplet exists on the surface carrying the acoustic wave, the energy and the momentum of the SAW will be coupled into the fluid, causing the liquid to vibrate and move on film surface. The strength of this movement is determined by the applied voltage and frequency. The volume of the liquid drop loaded on the SAW device in this study is of several hundreds of nanoliters. The movement of the liquid inside the droplet and also on the ZnO film surface can be demonstrated. The performance of ZnO SAW device was characterized as a function of film thickness

  9. Studies on spectroscopy of glycerol in THz range using microfluidic chip-integrated micropump

    Science.gov (United States)

    Su, Bo; Han, Xue; Wu, Ying; Zhang, Cunlin

    2014-11-01

    Terahertz time-domain spectroscopy (THz-TDS) is a detection method of biological molecules with label-free, non-ionizing, non-intrusive, no pollution and real-time monitoring. But owing to the strong THz absorption by water, it is mainly used in the solid state detection of biological molecules. In this paper, we present a microfluidic chip technique for detecting biological liquid samples using the transmission type of THz-TDS system. The microfluidic channel of the microfluidic chip is fabricated in the quartz glass using Micro-Electro-Mechanical System (MEMS) technology and sealed with polydimethylsiloxane (PDMS) diaphragm. The length, width and depth of the microfluidic channel are 25mm, 100μm and 50μm, respectively. The diameter of THz detection zone in the microfluidic channel is 4mm. The thicknesses of quartz glass and PDMS diaphragm are 1mm and 250μm, individually. Another one of the same quartz glass is used to bond with the PDMS for the rigidity and air tightness of the microfluidic chip. In order to realize the automation of sampling and improve the control precise of fluid, a micropump, which comprises PDMS diaphragm, pump chamber, diffuser and nozzle and flat vibration motor, is integrated on the microfluidic chip. The diffuser and nozzle are fabricated on both sides of the pump chamber, which is covered with PDMS diaphragm. The flat vibration motor is stuck on the PDMS diaphragm as the actuator. We study the terahertz absorption spectroscopy characteristics of glycerol with the concentration of 98% in the microfluidic chip by the aid of the THz-TDS system, and the feasibility of the microfluidic chip for the detection of liquid samples is proved.

  10. Design and experimental characterization of a NiTi-based, high-frequency, centripetal peristaltic actuator

    International Nuclear Information System (INIS)

    Development and experimental testing of a peristaltic device actuated by a single shape-memory NiTi wire are described. The actuator is designed to radially shrink a compliant silicone pipe, and must work on a sustained basis at an actuation frequency that is higher than those typical of NiTi actuators. Four rigid, aluminum-made circular sectors are sitting along the pipe circumference and provide the required NiTi wire housing. The aluminum assembly acts as geometrical amplifier of the wire contraction and as heat sink required to dissipate the thermal energy of the wire during the cooling phase. We present and discuss the full experimental investigation of the actuator performance, measured in terms of its ability to reduce the pipe diameter, at a sustained frequency of 1.5 Hz. Moreover, we investigate how the diameter contraction is affected by various design parameters as well as actuation frequencies up to 4 Hz. We manage to make the NiTi wire work at 3% in strain, cyclically providing the designed pipe wall displacement. The actuator performance is found to decay approximately linearly with actuation frequencies up to 4 Hz. Also, the interface between the wire and the aluminum parts is found to be essential in defining the functional performance of the actuator. (paper)

  11. Motion generation of peristaltic mobile robot with particle swarm optimization algorithm

    Science.gov (United States)

    Homma, Takahiro; Kamamichi, Norihiro

    2015-03-01

    In developments of robots, bio-mimetics is attracting attention, which is a technology for the design of the structure and function inspired from biological system. There are a lot of examples of bio-mimetics in robotics such as legged robots, flapping robots, insect-type robots, fish-type robots. In this study, we focus on the motion of earthworm and aim to develop a peristaltic mobile robot. The earthworm is a slender animal moving in soil. It has a segmented body, and each segment can be shorted and lengthened by muscular actions. It can move forward by traveling expanding motions of each segment backward. By mimicking the structure and motion of the earthworm, we can construct a robot with high locomotive performance against an irregular ground or a narrow space. In this paper, to investigate the motion analytically, a dynamical model is introduced, which consist of a series-connected multi-mass model. Simple periodic patterns which mimic the motions of earthworms are applied in an open-loop fashion, and the moving patterns are verified through numerical simulations. Furthermore, to generate efficient motion of the robot, a particle swarm optimization algorithm, one of the meta-heuristic optimization, is applied. The optimized results are investigated by comparing to simple periodic patterns.

  12. A Peristaltic Pump Integrated on a 100% Glass Microchip Using Computer Controlled Piezoelectric Actuators

    Directory of Open Access Journals (Sweden)

    Yo Tanaka

    2014-05-01

    Full Text Available Lab-on-a-chip technology is promising for the miniaturization of chemistry, biochemistry, and/or biology researchers looking to exploit the advantages of a microspace. To manipulate fluid on a microchip, on-chip pumps are indispensable. To date, there have been several types of on-chip pumps including pneumatic, electroactive, and magnetically driven. However these pumps introduce polymers, metals, and/or silicon to the microchip, and these materials have several disadvantages, including chemical or physical instability, or an inherent optical detection limit. To overcome/avoid these issues, glass has been one of the most commonly utilized materials for the production of multi-purpose integrated chemical systems. However, glass is very rigid, and it is difficult to incorporate pumps onto glass microchips. This paper reports the use of a very flexible, ultra-thin glass sheet (minimum thickness of a few micrometers to realize a pump installed on an entirely glass-based microchip. The pump is a peristaltic-type, composed of four serial valves sealing a cavity with two penetrate holes using ultra-thin glass sheet. By this pump, an on-chip circulating flow was demonstrated by directly observing fluid flow, visualized via polystyrene tracking particles. The flow rate was proportional to the pumping frequency, with a maximum flow rate of approximately 0.80 μL/min. This on-chip pump could likely be utilized in a wide range of applications which require the stability of a glass microchip.

  13. Hall and ion slip effects on peristaltic flow and heat transfer analysis with Ohmic heating

    Institute of Scientific and Technical Information of China (English)

    S ASGHAR; Q HUSSAIN; T HAYAT; F ALSAADI

    2014-01-01

    The peristaltic transport of a magnetohydrodynamic (MHD) fluid is exam-ined for both symmetric and asymmetric channels. Hall and ion slip effects are taken into account. The heat transfer is analyzed by considering the effects of viscous and Ohmic dissipations. The relevant flow problems are first modeled, and then the closed form solutions are constructed under the assumptions of long wavelength and low Reynolds number. The solutions are analyzed through graphical illustration. It is noted that the velocity increases but the temperature decreases with the increases in the Hall and ion slip parameters. The axial pressure gradient is less in magnitude in the presence of Hall and ion slip currents. The Hall and ion slip effects are to decrease the maximum pres-sure against which peristalsis works as a pump. The free pumping flux decreases with the increases in the Hall and ion slip parameters. The increases in the Hall and ion slip parameters result in an increase in the size of the trapped bolus.

  14. Peristaltic flow of a micropolar fluid through a porous medium in the presence of an external magnetic field

    Science.gov (United States)

    Pandey, S. K.; Chaube, M. K.

    2011-09-01

    This paper presents an analytical study of the MHD flow of a micropolar fluid through a porous medium induced by sinusoidal peristaltic waves traveling down the channel walls. Low Reynolds number and long wavelength approximations are applied to solve the non-linear problem in the closed form and expressions for axial velocity, pressure rise per wavelength, mechanical efficiency and stream function are obtained. The impacts of pertinent parameters on the aforementioned quantities are examined by plotting graphs on the basis of computational results. It is found that the pumping improves with Hartman number but degrades with permeability of the porous medium.

  15. Numerical Analysis for Peristaltic Motion of MHD Eyring-Prandtl Fluid in an Inclined Symmetric Cannel with Inclined Magnetic Field

    Directory of Open Access Journals (Sweden)

    Fahad Abbasi

    2016-01-01

    Full Text Available This article addresses the peristaltic transport of Eyring-Prandtl fluid in an inclined asymmetric channel. Heat and mass transfer phenomena along with Soret and Dufour effects is analyzed. Effects of inclined magnetic field and Joule heating are also discussed. Long wavelength approximation is adopted. Numerical computations for flow quantities of interest are analyzed. It is found that the parabolic velocity profile tends to shift from center of the channel towards the channel walls in the case of opposing flow. Velocity and temperature decrease whereas concentration increases by increasing the non-Newtonian parameter. Further the dependence of magnetic field on the angle is quite significant

  16. Analytical Analysis of Peristaltic Flow of a Six Constant Jeffreys Model of Fluid in an Inclined Planar Channel

    Directory of Open Access Journals (Sweden)

    Safia AKRAM

    2013-01-01

    Full Text Available In this paper we have investigated the peristaltic flow of an incompressible six constant Jeffreys model of fluid in an asymmetric channel. The flow is investigated in a wave frame of reference moving with the velocity of the wave. We have modeled the governing equations of a two dimensional six constant Jeffreys model of fluid under long wave length and low Reynolds number approximation. The analytical and numerical solutions of the proposed problem are discussed. The expression for the pressure rise is calculated using numerical integration. The Graphical results are presented to interpret various physical parameters of interest.

  17. Copper oxide nanoparticles analysis with water as base fluid for peristaltic flow in permeable tube with heat transfer.

    Science.gov (United States)

    Akbar, Noreen Sher; Raza, M; Ellahi, R

    2016-07-01

    The peristaltic flow of a copper oxide water fluid investigates the effects of heat generation and magnetic field in permeable tube is studied. The mathematical formulation is presented, the resulting equations are solved exactly. The obtained expressions for pressure gradient, pressure rise, temperature, velocity profile are described through graphs for various pertinent parameters. It is found that pressure gradient is reduce with enhancement of particle concentration and velocity profile is upturn, beside it is observed that temperature increases as more volume fraction of copper oxide. The streamlines are drawn for some physical quantities to discuss the trapping phenomenon. PMID:27208518

  18. Peristaltic Transport of a Physiological Fluid in an Asymmetric Porous Channel in the Presence of an External Magnetic Field

    CERN Document Server

    Misra, J C; Shit, G C; 10.1142/S0219519408002784

    2010-01-01

    The paper deals with a theoretical investigation of the peristaltic transport of a physiological fluid in a porous asymmetric channel under the action of a magnetic field. The stream function, pressure gradient and axial velocity are studied by using appropriate analytical and numerical techniques. Effects of different physical parameters such as permeability, phase difference, wave amplitude and magnetic parameter on the velocity, pumping characteristics, streamline pattern and trapping are investigated with particular emphasis. The computational results are presented in graphical form. The results are found to be in perfect agreement with those of a previous study carried out for a non-porous channel in the absence of a magnetic field.

  19. Mixed convective heat and mass transfer analysis for peristaltic transport in an asymmetric channel with Soret and Dufour effects

    Institute of Scientific and Technical Information of China (English)

    F M Abbasi; A Alsaedi; T Hayat

    2014-01-01

    The present investigation addresses the simultaneous effects of heat and mass transfer in the mixed convection peristaltic flow of viscous fluid in an asymmetric channel. The channel walls exhibit the convective boundary conditions. In addition, the effects due to Soret and Dufour are taken into consideration. Resulting problems are solved for the series solutions. Numerical values of heat and mass transfer rates are displayed and studied. Results indicate that the concentration and temperature of the fluid increase whereas the mass transfer rate at the wall decreases with increase of the mass transfer Biot number. Furthermore, it is observed that the temperature decreases with the increase of the heat transfer Biot number.

  20. On-demand wireless infusion rate control in an implantable micropump for patient-tailored treatment of chronic conditions.

    Science.gov (United States)

    Sheybani, Roya; Meng, Ellis

    2014-01-01

    Wireless infusion rate control and programmability for an implantable, low power, electrochemical micropump is presented. Flow rate control was achieved through adjustment of the wiper position of a current potentiometer in the wireless receiver (0.6-3.2 mA output current with a resolution of 0.2 mA per step). An off-the-shelf Bluetooth module and Basic Stamp microcontroller kit was used to initiate amplitude-shift keying (ASK) modulation of the inductive power signal. Accurate flow control of two model regimens was achieved on benchtop. Wireless transmission (power transfer and control) was not affected by simulated tissue material placed between the transmitter and receiver. PMID:25570100

  1. Effect of radiation and magnetic field on peristaltic transport of nanofluids through a porous space in a tapered asymmetric channel

    Energy Technology Data Exchange (ETDEWEB)

    Kothandapani, M., E-mail: mkothandapani@gmail.com [Department of Mathematics, University College of Engineering Arni, (A Constituent College of Anna University Chennai), Arni 632326, Tamil Nadu (India); Prakash, J., E-mail: prakashjayavel@yahoo.co.in [Department of Mathematics, Arulmigu Meenakshi Amman College of Engineering, Vadamavandal 604410, Tamil Nadu (India)

    2015-03-15

    Theoretical analyses on the effect of radiation and MHD on the peristaltic flow of a nanofluid through a porous medium in a two dimensional tapered asymmetric channel has been made. The nanofluid is assumed to be electrically conducting in the presence of a uniform magnetic field. The transport equation accounts the both Brownian motion and thermophoresis along with the radiation reaction. The problem has been further simplified with the authentic assumptions of long wavelength and small Reynolds number. The analytical expressions obtained for the axial velocity, stream function, temperature field, nanoparticle fraction field and pressure gradient provide satisfactory explanation. Influence of various parameters on the flow characteristics have been discussed with the help of graphical results. The trapping phenomenon has also been discussed in detail. - Highlights: • Combine effect of thermal radiation and MHD on the peristaltic flow of a Newtonian nanofluid are discussed. • This work may be first attempt dealing the study of Newtonian nanofluid flow in the porous tapered asymmetric channel. • The velocity, stream function, temperature field and nanoparticle fraction field provide satisfactory explanation with help of graphs.

  2. Effect of radiation and magnetic field on peristaltic transport of nanofluids through a porous space in a tapered asymmetric channel

    International Nuclear Information System (INIS)

    Theoretical analyses on the effect of radiation and MHD on the peristaltic flow of a nanofluid through a porous medium in a two dimensional tapered asymmetric channel has been made. The nanofluid is assumed to be electrically conducting in the presence of a uniform magnetic field. The transport equation accounts the both Brownian motion and thermophoresis along with the radiation reaction. The problem has been further simplified with the authentic assumptions of long wavelength and small Reynolds number. The analytical expressions obtained for the axial velocity, stream function, temperature field, nanoparticle fraction field and pressure gradient provide satisfactory explanation. Influence of various parameters on the flow characteristics have been discussed with the help of graphical results. The trapping phenomenon has also been discussed in detail. - Highlights: • Combine effect of thermal radiation and MHD on the peristaltic flow of a Newtonian nanofluid are discussed. • This work may be first attempt dealing the study of Newtonian nanofluid flow in the porous tapered asymmetric channel. • The velocity, stream function, temperature field and nanoparticle fraction field provide satisfactory explanation with help of graphs

  3. Peristaltic transport of MHD Williamson fluid in an inclined asymmetric channel through porous medium with heat transfer

    Institute of Scientific and Technical Information of China (English)

    K. Ramesh; M. Devakar

    2015-01-01

    The intention of this investigation is to study the effects of heat transfer and inclined magnetic field on the peristaltic flow of Williamson fluid in an asymmetric channel through porous medium. The governing two-dimensional equations are simplified under the assumption of long wavelength approximation. The simplified equations are solved for the stream function, temperature, and axial pressure gradient by using a regular perturbation method. The expression for pressure rise is computed numerically. The profiles of velocity, pressure gradient, temperature, heat transfer coefficient and stream function are sketched and interpreted for various embedded parameters and also the behavior of stream function for various wave forms is discussed through graphs. It is observed that the peristaltic velocity increases from porous medium to non-porous medium, the magnetic effects have increasing effect on the temperature, and the size of the trapped bolus decreases with the increasing of magnetic effects while the trend is reversed with the increasing of Darcy number. Moreover, limiting solutions of our problem are in close agreement with the corresponding results of the Newtonian fluid model.

  4. Peristaltic hemodynamic flow of couple stress fluid through a porous medium under the influence of magnetic field with slip effect

    Science.gov (United States)

    Swarnalathamma, B. V.; Krishna, M. Veera

    2016-05-01

    In this paper, we discussed the theoretical and computational study of peristaltic hemodynamic flow of couple stress fluids through a porous medium under the influence of magnetic field with wall slip condition. Actually this study is motivated towards the physiological flow of the blood in the micro circulatory system by taking account of the particle size effect. We consider the Reynolds number is small enough and the wave length to diameter ratio is large enough to negate inertial effects. The governing equations for the couple stress fluid flow through porous medium based on stoke constitutive equations and Brinkman model. The exact solutions for axial velocity, pressure gradient, frictional force, stream function and mechanical efficiency are obtained analytically, its behaviour computationally discussed with reference to different physical parameters reflecting couple stress parameter, Hartmann number, permeability parameter, slip parameter as well as amplitude ratio on pumping characteristics and frictional force, stream lines pattern and trapping of peristaltic flow pattern are studied with particular emphasis making use of graphs.

  5. Detection of Crohn's disease: Comparison of CT and MR enterography without anti-peristaltic agents performed on the same day

    International Nuclear Information System (INIS)

    Objective: To directly compare CT enterography (CTE) and MR enterography (MRE) without antiperistaltic agents. Materials/methods: 26 patients referred for CTE underwent CTE immediately followed by MRE without use of an anti-peristaltic agent. Each study was evaluated on a 10 point scale for exam quality, level of diagnostic confidence, and presence of Crohn's disease. Kappa analysis was performed to determine the degree of agreement between the CTE and MRE of each patient. Results: 25 patients completed the MRE. The quality of the CTEs was judged as excellent by both readers (reader 1 = average 9.5/10, reader 2 = average 9.1/10). The quality of the MREs was ranked lower than the CTEs by both readers (reader 1 = average 8.9/10, reader 2 = average 7.2/10), which was statistically significant (p < 0.05). The level of confidence in interpretation was not significantly different between CTE and MRE for reader 1 or 2 (p = 0.3). There was substantial agreement between readers for the presence or absence of Crohn's disease on both CTE (kappa = 0.75) and MRE (kappa = 0.67). Conclusion: MR enterography without anti-peristaltic agents results in high diagnostic confidence and excellent agreement for the presence of Crohn's disease.

  6. Effect of cross sectional geometry on PDMS micro peristaltic pump performance: comparison of SU-8 replica molding vs. micro injection molding.

    Science.gov (United States)

    Graf, Neil J; Bowser, Michael T

    2013-10-01

    Two different fabrication methods were employed to fabricate micropumps with different cross-sectional channel geometries. The first was to fabricate rectangular cross-sectional microchannel geometries using the well known fabrication method of replica molding (REM). The second, and far less utilized fabrication technique, was to create microchannel molds using an in-house fabricated handheld micro injection molding apparatus. The injection mold apparatus was designed for use with elastomeric room temperature vulcanization (RTV) polymers, as opposed to most other injection molding machines, which are designed for use with thermoplastic polymers. The injection mold's bottom plate was used as a microchannel molding template. The molding template was created by threading a small-diameter wire (150 μm or less) through the injection mold's bottom plate, with subsequent adhesion and smoothing of a thin piece of aluminum foil over the wire-raised injection mold template. When molded against, the template produced a rounded/Gaussian-shaped PDMS microchannel. The design of the injection mold will be presented, along with a direct comparison for micropump performance metrics such as flow rate, valving characteristics, and maximum backpressures attainable for each of the respective micropump channel geometries. PMID:23917263

  7. The Influence of a Micropolar Fluid on Peristaltic Transport in an Annulus: Application of the Clot Model

    Directory of Open Access Journals (Sweden)

    Kh. S. Mekheimer

    2008-01-01

    Full Text Available A serious pathological condition is encountered when some blood constituents deposited on the blood vessels get detached from the wall, join the blood stream again and form a clot. Study of the peristaltic transport of a micropolar fluid in an annular region is investigated under low Reynolds number and long wavelength approximations. We model a small artery as a tube having a sinusoidal wave travelling down its wall and a clot model inside it. Closed form solutions are obtained for the velocity and the microrotation components, as well as the stream function, and they contain new additional parameters, namely, δ, the height of the clot, N, the coupling number and m, the micropolar parameter. The pressure rise and friction force on the inner and the outer tubes have been discussed for various values of the physical parameters of interest.

  8. Numerical analysis for MHD peristaltic transport of Carreau-Yasuda fluid in a curved channel with Hall effects

    Science.gov (United States)

    Abbasi, F. M.; Hayat, T.; Alsaedi, A.

    2015-05-01

    Impact of applied magnetic field on the peristaltic transport of Carreau-Yasuda fluid in a curved conduit is analyzed in this article. Hall effects are also taken into consideration. Lubrication approach is utilized in problem formulation. Resulting nonlinear system is solved numerically. Results for axial velocity, pressure gradient, pressure rise per wavelength and stream function are obtained and studied graphically. Results revealed that for small values of curvature parameter the fluid velocity is not symmetric about the centerline. Also increase in the value of Hall parameter balances the magnetic influence of applied magnetic field by some extent. Further, the Carreau-Yasuda fluid possesses large size of trapped bolus when compared with the Newtonian fluid.

  9. Numerical analysis for MHD peristaltic transport of Carreau–Yasuda fluid in a curved channel with Hall effects

    Energy Technology Data Exchange (ETDEWEB)

    Abbasi, F.M., E-mail: abbasisarkar@gmail.com [Department of Mathematics, Comsats Institute of Information Technology, Islamabad 44000 (Pakistan); Hayat, T. [Department of Mathematics, Quaid-I-Azam University, 45320 Islamabad 44000 (Pakistan); Nonlinear Analysis and Applied Mathematics (NAAM) Research Group, Faculty of Science, King Abdulaziz University, Jeddah 21589 (Saudi Arabia); Alsaedi, A. [Nonlinear Analysis and Applied Mathematics (NAAM) Research Group, Faculty of Science, King Abdulaziz University, Jeddah 21589 (Saudi Arabia)

    2015-05-15

    Impact of applied magnetic field on the peristaltic transport of Carreau–Yasuda fluid in a curved conduit is analyzed in this article. Hall effects are also taken into consideration. Lubrication approach is utilized in problem formulation. Resulting nonlinear system is solved numerically. Results for axial velocity, pressure gradient, pressure rise per wavelength and stream function are obtained and studied graphically. Results revealed that for small values of curvature parameter the fluid velocity is not symmetric about the centerline. Also increase in the value of Hall parameter balances the magnetic influence of applied magnetic field by some extent. Further, the Carreau–Yasuda fluid possesses large size of trapped bolus when compared with the Newtonian fluid.

  10. Effects of magnetic field and wall slip conditions on the peristaltic transport of a Newtonian fluid in an asymmetric channel

    International Nuclear Information System (INIS)

    The effects of both magnetic field and wall slip conditions on the peristaltic transport of a Newtonian fluid in an asymmetric channel are studied analytically and numerically. The channel asymmetry is generated by propagation of waves on the channel walls travelling with different amplitudes, phases but with the same speed. The long wavelength and low Reynolds number assumptions are considered in obtaining solution for the flow. The flow is investigated in a wave frame of reference moving with velocity of the wave. Closed form expressions have been obtained for the stream function and the axial velocity component in fixed frame. The effects of phase difference, Knudsen number and magnetic field on the pumping characteristics and velocity field are discussed. Several known results of interest are found to follow as particular cases of the solution of the problem considered

  11. Influences of rotation and thermophoresis on MHD peristaltic transport of Jeffrey fluid with convective conditions and wall properties

    Science.gov (United States)

    Hayat, T.; Rafiq, M.; Ahmad, B.

    2016-07-01

    This article aims to predict the effects of convective condition and particle deposition on peristaltic transport of Jeffrey fluid in a channel. The whole system is in a rotating frame of reference. The walls of channel are taken flexible. The fluid is electrically conducting in the presence of uniform magnetic field. Non-uniform heat source/sink parameter is also considered. Mass transfer with chemical reaction is considered. Relevant equations for the problems under consideration are first modeled and then simplified using lubrication approach. Resulting equations for stream function and temperature are solved exactly whereas mass transfer equation is solved numerically. Impacts of various involved parameters appearing in the solutions are carefully analyzed.

  12. Influence of Magnetic Field on the Peristaltic Flow of a Viscous Fluid through a Finite-Length Cylindrical Tube

    Directory of Open Access Journals (Sweden)

    S. K. Pandey

    2010-01-01

    Full Text Available The paper presents an analytical investigation of the peristaltic transport of a viscous fluid under the influence of a magnetic field through a tube of finite length in a dimensionless form. The expressions of pressure gradient, volume flow rate, average volume flow rate and local wall shear stress have been obtained. The effects of the transverse magnetic field and electrical conductivity (i.e. the Hartmann number on the mechanical efficiency of a peristaltic pump have also been studied. The reflux phenomenon is also investigated. It is concluded, on the basis of the pressure distribution along the tubular length and pumping efficiency, that if the transverse magnetic field and the electric conductivity increase, the pumping machinery exerts more pressure for pushing the fluid forward. There is a linear relation between the averaged flow rate and the pressure applied across one wavelength that can restrain the flow due to peristalsis. It is found that there is a particular value of the averaged flow rate corresponding to a particular pressure that does not depend on the Hartmann number. Naming these values ‘critical values’, it is concluded that the pressure required for checking the flow increases with the Hartmann number above the critical value and decreases with it below the critical value. It is also inferred that magneto-hydrodynamic parameters make the fluid more prone to flow reversal. The conclusion applied to oesophageal swallowing reveals that normal water is easier to swallow than saline water. The latter is more prone to flow reversal. A significant difference between the propagation of the integral and non-integral number of waves along the tube is that pressure peaks are identical in the former and different in the latter cases.

  13. Effects of flow properties on the performance of a diffuser-nozzle element of a valveless micropump

    Science.gov (United States)

    Das, Partha Kumar; Hasan, A. B. M. Toufique

    2016-07-01

    The flow behaviour and performance parameters of a diffuser-nozzle element of a valveless micropump have been investigated for different driving pressure frequencies. When a fluctuating pressure is imposed on the inlet boundary of a diffuser-nozzle element, there is a net flow in diffuser direction due to the dynamic effect. The variation of this net flow along with rectification capacity, and diffuser efficiency has been investigated for different frequencies of driving pressure. Flow behaviour and recirculation region due to dynamic effect have been studied as qualitative study. Pressure and velocity have been analyzed for quantitative analysis and for validation with results found in literature. 2-D geometry has been used in the present study. 3-D geometry has been modeled to justify the results obtained from 2-D analysis. Five different pressure frequencies ranging from 5 kHz to 50 kHz have been used to investigate their effects on the performance of diffuser-nozzle element in high frequency ranges. The net flow and performance of the nozzle-diffuser element are found to be decreasing with the increasing frequency. The performance is found to be less sensitive to frequency at high pressure range (above 30 kHz).

  14. Peristaltic Motion of Non-Newtonian Fluid with Heat and Mass Transfer through a Porous Medium in Channel under Uniform Magnetic Field

    OpenAIRE

    Eldabe, Nabil T. M.; Bothaina M. Agoor; Heba Alame

    2014-01-01

    This paper is devoted to the study of the peristaltic motion of non-Newtonian fluid with heat and mass transfer through a porous medium in the channel under the effect of magnetic field. A modified Casson non-Newtonian constitutive model is employed for the transport fluid. A perturbation series’ method of solution of the stream function is discussed. The effects of various parameters of interest such as the magnetic parameter, Casson parameter, and permeability parameter on the velocity, pre...

  15. Influence of magnetic field and heat transfer on peristaltic flow of Jeffrey fluid through a porous medium in an asymmetric channel

    OpenAIRE

    C. Vasudev; U.Rajeswara Rao; M. V. Subba Reddy; G. Prabhakara Rao

    2010-01-01

    In this paper, we studied the effects of heat transfer and magnetic field on the peristaltic flow of a Jeffrey fluid through a porous medium in an asymmetric channel under the assumptions of long wavelength and low Reynolds number. Expressions for the velocity and pressure gradient are obtained analytically. The effects of Hartmann number, Darcy number, phase shift, Jeffrey fluid parameter and upper and lower wave amplitudes on the pumping characteristics and the temperature field are discuss...

  16. Activation of the umami taste receptor (T1R1/T1R3) initiates the peristaltic reflex and pellet propulsion in the distal colon

    OpenAIRE

    Kendig, Derek M; Hurst, Norman R.; Bradley, Zachary L.; Mahavadi, Sunila; Kuemmerle, John F.; Lyall, Vijay; DeSimone, John; Murthy, Karnam S.; John R Grider

    2014-01-01

    Intraluminal nutrients in the gut affect the peristaltic reflex, although the mechanism is not well defined. Recent evidence supports the presence of taste receptors and their signaling components in enteroendocrine cells, although their function is unclear. This study aimed to determine if nutrients modify colonic motility through activation of taste receptors. Colonic sections were immunostained for the umami taste receptor T1R1/T1R3, which mediates the response to umami ligands, such as mo...

  17. Microfabricated reciprocating micropump for intracochlear drug delivery with integrated drug/fluid storage and electronically controlled dosing.

    Science.gov (United States)

    Tandon, Vishal; Kang, Woo Seok; Robbins, Tremaan A; Spencer, Abigail J; Kim, Ernest S; McKenna, Michael J; Kujawa, Sharon G; Fiering, Jason; Pararas, Erin E L; Mescher, Mark J; Sewell, William F; Borenstein, Jeffrey T

    2016-03-01

    The anatomical and pharmacological inaccessibility of the inner ear is a major challenge in drug-based treatment of auditory disorders. This also makes pharmacokinetic characterization of new drugs with systemic delivery challenging, because efficacy is coupled with how efficiently a drug can reach its target. Direct delivery of drugs to cochlear fluids bypasses pharmacokinetic barriers and helps to minimize systemic toxicity, but anatomical barriers make administration of multiple doses difficult without an automated delivery system. Such a system may be required for hair-cell regeneration treatments, which will likely require timed delivery of several drugs. To address these challenges, we have developed a micropump for controlled, automated inner-ear drug delivery with the ultimate goal of producing a long-term implantable/wearable delivery system. The current pump is designed to be used with a head mount for guinea pigs in preclinical drug characterization experiments. In this system, we have addressed several microfluidic challenges, including maintaining controlled delivery at safe, low flow rates and delivering drug without increasing the volume of fluid in the cochlea. By integrating a drug reservoir and all fluidic components into the microfluidic structure of the pump, we have made the drug delivery system robust compared to previous systems that utilized separate, tubing-connected components. In this study, we characterized the pump's unique infuse-withdraw and on-demand dosing capabilities on the bench and in guinea pig animal models. For the animal experiments, we used DNQX, a glutamate receptor antagonist, as a physiological indicator of drug delivery. DNQX suppresses compound action potentials (CAPs), so we were able to infer the distribution and spreading of the DNQX over time by measuring the changes in CAPs in response to stimuli at several characteristic frequencies. PMID:26778829

  18. Low-Power, Low-Voltage Electroosmotic Actuator for an Implantable Micropumping System Intended for Drug Delivery Applications

    Science.gov (United States)

    Getpreecharsawas, Jirachai

    An electroosmotic (EO) actuator offers a low-power, low-voltage alternative in a diaphragm-based periodic displacement micropump intended for an implantable drug delivery system. The actuator utilizes an electroosmosis mechanism to transport liquid across a membrane to deflect the pumping diaphragms in a reciprocating manner. In the study, the membrane made of porous nanocrystalline silicon (pnc-Si) tens of nanometers in thickness was used as the promising EO generator with low power consumption and small package size. This ultrathin membrane provides the opportunity for electrode integration such that the very high electric field can be generated across the membrane with the applied potential under 1 volt for low flow rate applications like drug delivery. Due to such a low applied voltage, the challenge, however, imposes on the capability of generating the pumping pressure high enough to deflect the pumping diaphragms and overcome the back pressure normally encountered in the biological tissue and organ. This research identified the cause of weak pumping pressure that the electric field inside the orifice-like nanopores of the ultrathin membrane is weaker than conventional theory would predict. It no longer scales uniformly with the thickness of membrane, but with the pore length-to-diameter aspect ratio for each nanopore. To enhance the pumping performance, the pnc-Si membrane was coated with an ultrathin Nafion film. As a result, the induced concentration difference across the Nafion film generates the osmotic pressure against the back pressure allowing the EO actuator to maintain the target pumping flow rate under 1 volt.

  19. A highly reproducible solenoid micropump system for the analysis of total inorganic carbon and ammonium using gas-diffusion with conductimetric detection.

    Science.gov (United States)

    Henríquez, Camelia; Horstkotte, Burkhard; Cerdà, Víctor

    2014-01-01

    In this work, a simple, economic, and miniaturized flow-based analyzer based on solenoid micropumps is presented. It was applied to determine two parameters of high environmental interest: ammonium and total inorganic carbon (TIC) in natural waters. The method is based on gas diffusion (GD) of CO₂ and NH3 through a hydrophobic gas permeable membrane from an acidic or alkaline donor stream, respectively. The analytes are trapped in an acceptor solution, being slightly alkaline for CO₂ and slightly acidic for NH₃. The analytes are quantified using a homemade stainless steel conductimetric cell. The proposed system required five solenoid micro-pumps, one for each reagent and sample. Two especially made air bubble traps were placed down-stream of the solendoid pumps, which provided the acceptor solutions, by this increasing the method's reproducibility. Values of RSD lower than 1% were obtained. Achieved limits of detection were 0.27 µmol L⁻¹ for NH₄⁺ and 50 µmol L⁻¹ for TIC. Add-recovery tests were used to prove the trueness of the method and recoveries of 99.5 ± 7.5% were obtained for both analytes. The proposed system proved to be adequate for monitoring purpose of TIC and NH₄⁺ due to its high sample throughput and repeatability. PMID:24274287

  20. 磁流体微泵研究进展及其关键问题%Research Progress on MHD Micro-Pump and its Key Problems

    Institute of Scientific and Technical Information of China (English)

    赵凌志; 李建; 彭燕

    2011-01-01

    Magnetohydrodynamics (MHD) micro-pump offers an elegant means to drive and control bio-micro-fluid flow without a need for mechanical components. In this paper, we present the theory, describe typical prototypes of AC MHD and DC MHD micro-pumps, and discuss the key problems, such as electrochemical reaction, magnetohydrodynamics under micro-and nano-scale, micro-processing technology and materials of MHD micro-pumps.%磁流体(magnetohydrodynamics,MHD)微泵没有机械部件,但能够产生连续的流动,是当前电磁生物的研究热点之一.本文在详细阐述MHD微泵的工作原理、介绍交流磁流体(AC MHD)微泵和直流磁流体(DC MHD)微泵典型样机的基础上,着重分析了MHD微泵的电化学反应、微尺度下的电磁流体动力学以及微加工技术和材料等关键科学技术问题.

  1. Design and fabrication process of a micropump using bulk Pb(Zr,Ti)O 3 for microfluidic devices

    Science.gov (United States)

    Sakamoto, Ryohei; Dau, Van Thanh; Dao, Dzung Viet; Tanaka, Katsuhiko; Sugiyama, Susumu

    2007-12-01

    This paper reports on the design and simulation of a new valve-less pump for use in microfluidic applications. The simple-structure micropump comprises a piezoelectric Pb(Zr,Ti)O 3 (PZT) - Si diaphragm and flow channels which are fabricated using silicon micromachining techniques. The silicon diaphragm (5×5×0.05mm 3) is driven by the PZT (45-μm thick) actuator that has quick response time and large driving force with low power consumption. A key technology to realize the pump diaphragm is the PZT-Si bonding process using a thin gold film as an intermediate layer. Under fabrication conditions of 550°C and 0.8 MPa, the strength of the bonding was experimentally validated to be 13 MPa. The maximum displacement of the diaphragm was measured to be 3 μm 0-P with driving voltage of 30 V p-p at resonance frequency of 10 kHz. Structural analysis of the diaphragm was done in terms of three-dimensional model using commercial software ANSYS. The flow channels are easily fabricated by silicon etching process. Design of flow channels focused on a cross junction formed by neck of the pump chamber, one outlet and two opposite inlet channels. This structure allows a difference in fluidic resistance and fluidic momentum to be created inside the channels during each pump vibration cycle. Two designs of the devices which have different channel depths, namely type A and type B, was investigated. Flow simulation was done by numerical transient model (using ANSYS-Fluent), in which only the measured deformation of the PZT diagram is applied and therefore no other assumptions are required. The results showed that the mass flow rate of the type A is 0.129×10 -6 kg/s (mean flow rate of 6.3 ml/min) and that of type B is 1.65×10 -6 kg/s (mean flow rate of 80.8 ml/min).

  2. Hall and radial magnetic field effects on radiative peristaltic flow of Carreau-Yasuda fluid in a channel with convective heat and mass transfer

    Science.gov (United States)

    Hayat, T.; Farooq, S.; Alsaedi, A.; Ahmad, B.

    2016-08-01

    The purpose of present investigation is to study the Hall and MHD effects on peristaltic flow of Carreau-Yasuda fluid in a convectively curved configuration. Thermal radiation, Soret and Dufour effects are also accounted. The channel walls comprised the no slip and compliant properties. Constitutive equations for mass, momentum, energy and concentration are first modeled in view of considered assumptions and then simplified under long wavelength and low Reynolds number approximation. Solution of the resulting system of equations is carried out via a regular perturbation technique. Physical behaviors of velocity, temperature, concentration and streamlines are discussed with the help of graphical representation.

  3. Effects of Slip Condition, Variable Viscosity and Inclined Magnetic Field on the Peristaltic Motion of a Non-Newtonian Fluid in an Inclined Asymmetric Channel

    Directory of Open Access Journals (Sweden)

    A. Afsar Khan

    2016-01-01

    Full Text Available The peristaltic motion of a third order fluid due to asymmetric waves propagating on the sidewalls of a inclined asymmetric channel is discussed. The key features of the problem includes longwavelength and low-Reynolds number assumptions. A mathematical analysis has been carried out to investigate the effect of slip condition, variable viscosity and magnetohydrodynamics (MHD. Followed by the nondimensionalization of the nonlinear governing equations along with the nonlinear boundary conditions, a perturbation analysis is made. For the validity of the approximate solution, a numerical solution is obtained using the iterative collocation technique.

  4. Peristaltic Motion of Non-Newtonian Fluid with Heat and Mass Transfer through a Porous Medium in Channel under Uniform Magnetic Field

    Directory of Open Access Journals (Sweden)

    Nabil T. M. Eldabe

    2014-01-01

    Full Text Available This paper is devoted to the study of the peristaltic motion of non-Newtonian fluid with heat and mass transfer through a porous medium in the channel under the effect of magnetic field. A modified Casson non-Newtonian constitutive model is employed for the transport fluid. A perturbation series’ method of solution of the stream function is discussed. The effects of various parameters of interest such as the magnetic parameter, Casson parameter, and permeability parameter on the velocity, pressure rise, temperature, and concentration are discussed and illustrated graphically through a set of figures.

  5. Effects of Heat and Mass Transfer on MHD Peristaltic Flow of a Non-Newtonian Fluid through a Porous Medium between Two Coaxial Cylinders

    Directory of Open Access Journals (Sweden)

    Abeer A. Shaaban

    2013-01-01

    Full Text Available We investigated the influence of heat and mass transfer on the peristaltic flow of magnetohydrodynamic Eyring-Powell fluid under low Reynolds number and long-wavelength approximation. The fluid flows between two infinite cylinders; the inner tube is uniform, rigid, and rest, while the outer flexible tube has a sinusoidal wave traveling down its wall. The governing equations are solved numerically using finite-difference technique. The velocity, temperature, and concentration distribution are obtained. The features of flow characteristics are analyzed by plotting graphs and discussed in detail.

  6. The influence of heat transfer and magnetic field on peristaltic transport of a Newtonian fluid in a vertical annulus: Application of an endoscope

    International Nuclear Information System (INIS)

    This Letter discusses the influence of heat transfer and magnetic field on the peristaltic flow of Newtonian fluid in a vertical annulus under a zero Reynolds number and long wavelength approximation. The inner tube is uniform, rigid, while the outer tube has a sinusoidal wave traveling down its wall. The flow is investigated in a wave frame of reference moving with velocity of the wave. Numerical calculations are carried out for the pressure rise and frictional forces. The features of the flow characteristics are analyzed by plotting graphs and discussed in detail

  7. Influence of magnetic field and heat transfer on peristaltic flow of Jeffrey fluid through a porous medium in an asymmetric channel

    Directory of Open Access Journals (Sweden)

    C. Vasudev

    2010-12-01

    Full Text Available In this paper, we studied the effects of heat transfer and magnetic field on the peristaltic flow of a Jeffrey fluid through a porous medium in an asymmetric channel under the assumptions of long wavelength and low Reynolds number. Expressions for the velocity and pressure gradient are obtained analytically. The effects of Hartmann number, Darcy number, phase shift, Jeffrey fluid parameter and upper and lower wave amplitudes on the pumping characteristics and the temperature field are discussed through graphs in detail.

  8. Influence of heat and mass transfer, initial stress and radially varying magnetic field on the peristaltic flow in an annulus with gravity field

    International Nuclear Information System (INIS)

    In this paper, the effects of both initial stress, radially varying and gravity field on the peristaltic flow of an incompressible MHD Newtonian fluid in a vertical annulus have been studied under the assumption of long wavelength and low-Reynolds number. The analytical solution has been derived for the temperature, concentration and velocity. The results for velocity, concentration and temperature obtained in the analytical form have been evaluated numerically and discussed briefly. The effect of the non-dimensional wave amplitude, the coefficient of viscosity, Sort number, Schmidt number, initial stress, gravitational field and the dimensionless time-mean flow in the wave frame are analyzed theoretically and computed numerically. The expressions for pressure rise, temperature, concentration field, velocity and pressure gradient are sketched for various embedded parameters and interpreted. Numerical results are given and illustrated graphically in each case considered. Comparison was made with the results obtained in the presence and absence of initial stress and gravitational field. - Highlights: • Initial stress, radially varying and gravity field on the peristaltic flow of MHD Newtonian fluid. • The analytical solution for the temperature, concentration and velocity. • Effect of wave amplitude, viscosity, Sort number, Schmidt number, initial stress, gravitational in the wave frame

  9. Influence of heat and mass transfer, initial stress and radially varying magnetic field on the peristaltic flow in an annulus with gravity field

    Energy Technology Data Exchange (ETDEWEB)

    Abd-Alla, A.M., E-mail: mohmrr@yahoo.com [Mathematics Department, Faculty of Science, Taif University 888 (Saudi Arabia); Mathematics Department, Faculty of Science, Sohag (Egypt); Abo-Dahab, S.M. [Mathematics Department, Faculty of Science, Taif University 888 (Saudi Arabia); Mathematics Department, Faculty of Science, SVU, Qena 83523 (Egypt); El-Shahrany, H.D. [Mathematics Department, Faculty of Science, Taif University 888 (Saudi Arabia)

    2014-08-01

    In this paper, the effects of both initial stress, radially varying and gravity field on the peristaltic flow of an incompressible MHD Newtonian fluid in a vertical annulus have been studied under the assumption of long wavelength and low-Reynolds number. The analytical solution has been derived for the temperature, concentration and velocity. The results for velocity, concentration and temperature obtained in the analytical form have been evaluated numerically and discussed briefly. The effect of the non-dimensional wave amplitude, the coefficient of viscosity, Sort number, Schmidt number, initial stress, gravitational field and the dimensionless time-mean flow in the wave frame are analyzed theoretically and computed numerically. The expressions for pressure rise, temperature, concentration field, velocity and pressure gradient are sketched for various embedded parameters and interpreted. Numerical results are given and illustrated graphically in each case considered. Comparison was made with the results obtained in the presence and absence of initial stress and gravitational field. - Highlights: • Initial stress, radially varying and gravity field on the peristaltic flow of MHD Newtonian fluid. • The analytical solution for the temperature, concentration and velocity. • Effect of wave amplitude, viscosity, Sort number, Schmidt number, initial stress, gravitational in the wave frame.

  10. Detection of Crohn's disease: Comparison of CT and MR enterography without anti-peristaltic agents performed on the same day

    Energy Technology Data Exchange (ETDEWEB)

    Grand, David J., E-mail: dgrand@lifespan.org [Department of Diagnostic Imaging, Warren Alpert School of Medicine, Brown University, 593 Eddy St., Providence, RI 02903 (United States); Beland, Michael D. [Department of Diagnostic Imaging, Warren Alpert School of Medicine, Brown University, 593 Eddy St., Providence, RI 02903 (United States); Machan, Jason T. [Department of Orthopaedics and Surgery, Warren Alpert School of Medicine, Brown University, 593 Eddy St., Providence, RI 02903 (United States); Mayo-Smith, William W. [Department of Diagnostic Imaging, Warren Alpert School of Medicine, Brown University, 593 Eddy St., Providence, RI 02903 (United States)

    2012-08-15

    Objective: To directly compare CT enterography (CTE) and MR enterography (MRE) without antiperistaltic agents. Materials/methods: 26 patients referred for CTE underwent CTE immediately followed by MRE without use of an anti-peristaltic agent. Each study was evaluated on a 10 point scale for exam quality, level of diagnostic confidence, and presence of Crohn's disease. Kappa analysis was performed to determine the degree of agreement between the CTE and MRE of each patient. Results: 25 patients completed the MRE. The quality of the CTEs was judged as excellent by both readers (reader 1 = average 9.5/10, reader 2 = average 9.1/10). The quality of the MREs was ranked lower than the CTEs by both readers (reader 1 = average 8.9/10, reader 2 = average 7.2/10), which was statistically significant (p < 0.05). The level of confidence in interpretation was not significantly different between CTE and MRE for reader 1 or 2 (p = 0.3). There was substantial agreement between readers for the presence or absence of Crohn's disease on both CTE (kappa = 0.75) and MRE (kappa = 0.67). Conclusion: MR enterography without anti-peristaltic agents results in high diagnostic confidence and excellent agreement for the presence of Crohn's disease.

  11. Influence of heat and mass transfer, initial stress and radially varying magnetic field on the peristaltic flow in an annulus with gravity field

    Science.gov (United States)

    Abd-Alla, A. M.; Abo-Dahab, S. M.; El-Shahrany, H. D.

    2014-08-01

    In this paper, the effects of both initial stress, radially varying and gravity field on the peristaltic flow of an incompressible MHD Newtonian fluid in a vertical annulus have been studied under the assumption of long wavelength and low-Reynolds number. The analytical solution has been derived for the temperature, concentration and velocity. The results for velocity, concentration and temperature obtained in the analytical form have been evaluated numerically and discussed briefly. The effect of the non-dimensional wave amplitude, the coefficient of viscosity, Sort number, Schmidt number, initial stress, gravitational field and the dimensionless time-mean flow in the wave frame are analyzed theoretically and computed numerically. The expressions for pressure rise, temperature, concentration field, velocity and pressure gradient are sketched for various embedded parameters and interpreted. Numerical results are given and illustrated graphically in each case considered. Comparison was made with the results obtained in the presence and absence of initial stress and gravitational field.

  12. Optimal Design and Operation for a No-Moving-Parts-Valve (NMPV Micro-Pump with a Diffuser Width of 500 µm

    Directory of Open Access Journals (Sweden)

    Jia-Ming Sun

    2009-05-01

    Full Text Available A no-moving-parts-valve (NMPV with a diffuser width of D = 500 microns was investigated in this study by numerical simulations at Reynolds numbers, ReD, ranging from 20 to 75, and expansion valve angles ranging from 30° < θ1 < 57° and 110° < θ2 < 120°. The D p,i value, 1.02 < D p,i < 1.14, is larger within the proposed range of the expansion valve angles. A flow channel structure with a depth of 500 micron is manufactured using yellow light lithography in this study. From prior analyses and experiments, it is found that piezoelectric films work better at a buzz driving frequency of f < 30Hz and the best operating frequency is at a driving frequency of f = 10Hz because it produces the largest net flow. In addition, the expansion angles θ1 = 30° and θ2 = 120° are the best expansion angles because they produce the largest net flow. These related results are very helpful for the actual design of no-moving-parts-valve micro-pump.

  13. The clinical monitoring and nursing of micro-pump potassium after surgery operation%外科术后微量泵经静脉补钾的临床监测及护理

    Institute of Scientific and Technical Information of China (English)

    李娟; 李勇兰; 党翠云; 曾小平

    2008-01-01

    To summarize the experience of clinical monitoring and nursing in patients who used the micro-pump potassium to rectify the hypokalemia after operation in ICU,heart surgery and common surgery department of our hospital.76 cases of hypokalemia were selected and used micro-pump to rectify the hypokalemia after surgery operation by intravenous infusion 10% liquids with original potassium chloride,the process was monitored and nursed closely.This prevented the occurrence of hypokalemia after operation effectively.During pumping potassium period,there was no phlebitis,no arrhythmia or other adverse effect occurred.Using micro-pump to supply potassium by vein to correct hypokalemia under tight clinical monitoring and nursing is effective and safe.%总结我院ICU、心脏外科、普外科病人术后使用微量泵泵钾纠正低钾血症的临床监测及护理体会.76例外科术后低钾血症患者使用微量注射泵经静脉输注浓度为10%氯化钾原液,以纠正低钾血症,补钾过程中进行严密监测和护理.有效预防了术后低血钾的发生.患者在泵钾期间无1例高钾血症发生,无静脉炎、心律失常等不良反应发生.严密的临床监测和护理下使用微量泵经静脉补钾纠正低钾血症的方法 是有效、安全的.

  14. Design and research of micro-pump based on photo-induced bending material%基于光致弯曲材料的微泵设计研究

    Institute of Scientific and Technical Information of China (English)

    朱玉田; 许溱; 陈茂林; 刘钊; 俞燕蕾

    2011-01-01

    Based on a photo-induced bending material which has two-way shape memory function,a novel micro-pump with valves was designed and made.Combined with material deformation principle,the micro-pump's finite element model was built by using the finite element software ANSYS,and the pumping capacity calculated by ANSYS was gained and compared with the one came from the pump prototype's experimental results,then the consistency of which validates this micro-pump design's rationality.The material application on micro-pump has some reference values for relative engineering application and the photo-induced bending effect equivalent also provides research methods for similar problems.%基于一种具有双向形状记忆功能的光致弯曲材料,设计了新型有阀微泵结构并制作了样机。结合材料的光致弯曲效应等效理论,采用ANSYS软件建立了微泵空腔结构的几何模型,并对所建模型的泵水体积进行了计算求解。对样机进行实验得到了微泵的实际泵水性能,将其与理论计算结果进行对比,得出两者基本一致的结论,从而验证了微泵结构设计的合理性。光致弯曲材料在微泵上的应用形式,对相关工程应用有一定的参考价值,光致效应的等效也为解决相关问题提供了研究方法。

  15. Efficacy of intravenous injection of urapidil by micro-pump in treatment of hypertensive emergency patients%经微量泵静脉注射乌拉地尔治疗高血压急症疗效观察

    Institute of Scientific and Technical Information of China (English)

    庄小静; 周朝虹

    2009-01-01

    目的 探讨乌拉地尔微量泵静脉注射治疗高血压急症的疗效和安全性.方法 对78例高血压急症患者用乌拉地尔50mg加入40ml液体中静脉微泵输注,监测并记录用药前及用药后5、10、30、60、120min血压(BP)、心率(HR)、伴随症状及不良反应.结果 应用乌拉地尔后各时段BP较用药前均明显下降,差异有统计学意义(P<0.05),而HR则无明显变化.结论 乌拉地尔微量泵静脉注射治疗高血压急症,疗效确切,不良反应少.%Objective To investigate the efficacy and safety of urapidil intravenous injected by micro-pump in treatment of hypertensive emergency patients. Methods There 78 cases with hypertensive, emergency werereated wih 50rag urapidil by intravenous micro-pump. The blood pressure (BP),heart rate (HR),adverse reactions were monitored and recorded before administration and 5min,10min,30min,60min,120min after administration. Results Compared to that before administration,blood pressure were significantly decreased after administration, showing a significant difference. While there was no significant difference in the heart rate. Conclusion Urapidil intravenous injected by micro-pump is effective for treatment of hypertensive emergency with fewer adverse reactions.

  16. Sewer Cleaning Inspection Robot Based on Peristaltic Walking%蠕动式污水管道清淤机器人

    Institute of Scientific and Technical Information of China (English)

    曹建树; 徐宝东; 鲁军; 刘强; 张义; 黄子茂

    2014-01-01

    采用模块化方法对污水管道清淤机器人中的管道清理单元、推进舱、阀组和控制单元等模块加以组合,并对其进行了总体方案设计,给出了机器人蠕动行走液压油路方案,分析了其蠕动行走过程。介绍了系统上、下位机联合控制方案,同时描述了下位机在控制系统中的功能及其对应程序流程。在此基础上,研制了一台污水管道清淤机器人,并对其进行了实验。结果表明:该机器人在现有方案下能够实现预定的设计目标,管道清理检测质量良好,可降低工人工作强度。%By combining pipe cleaning unit,propulsion module,valves and control with modularization method,the general scheme of a novel sewer cleaning inspection robot was designed. The peristaltic walking program based on hydraulic oil circuit of the ro-bot was given,and its peristaltic walking processes were analyzed. United control scheme of the system between host and lower comput-er was introduced. At the same time,the lower computer function in control system and its corresponding program flow were described. Upon this basis,a sewer cleaning inspection robot was developed and it was verified by testing experiments. The results show that the performances of robot have a good agreement with design aim in the scheme,and inspecting effect is good,which can reduce strength of worker.

  17. Influence of Heat Source, Thermal Radiation and Inclined Magnetic Field on Peristaltic Flow of a Hyperbolic Tangent Nanofluid in a Tapered Asymmetric Channel.

    Science.gov (United States)

    Kothandapani, Munirathinam; Prakash, Jayavel

    2014-10-31

    In the present analytic thinking, we have modeled the governing equations of a two dimensional peristaltic transport of a Hyperbolic tangent nanofluid in the presence of a heat source/sink with the combined effects of thermal radiation and inclined magnetic field in a tapered asymmetric channel. The propagation of waves on the non-uniform walls to have different amplitudes and phase but the same wave speed is produced the tapered asymmetric channel. The equations of dimensionless temperature and nanoparticle concentration are solved analytically under assumptions of long wavelength and low Reynolds number. The governing equations of momentum of a hyperbolic tangent nanofluid for the tapered asymmetric channel have also been solved analytically using the regular perturbation method. The expression for average rise in pressure has been figured using numerical integrations. The effects of various physical parameters entering into the problem are discussed numerically and graphically. The phenomenon of trapping is also investigated. Furthermore, the received results show that the maximum pressure rise gets increased in case of non-Newtonian fluid when equated with Newtonian fluid. PMID:25373110

  18. Effects of rotation and magnetic field on the nonlinear peristaltic flow of a second-order fluid in an asymmetric channel through a porous medium

    International Nuclear Information System (INIS)

    In this paper, the effects of both rotation and magnetic field of the peristaltic transport of a second-order fluid through a porous medium in a channel are studied analytically and computed numerically. The material is represented by the constitutive equations for a second-order fluid. Closed-form solutions under the consideration of long wavelength and low Reynolds number is presented. The analytical expressions for the pressure gradient, pressure rise, friction force, stream function, shear stress, and velocity are obtained in the physical domain. The effects of the non-dimensional wave amplitude, porosity, magnetic field, rotation, and the dimensionless time-mean flow in the wave frame are analyzed theoretically and computed numerically. Numerical results are given and illustrated graphically in each case considered. Comparison was made with the results obtained in the presence and absence of rotation, magnetic field, and porosity. The results indicate that the effects of the non-dimensional wave amplitude, porosity, magnetic field, rotation, and the dimensionless time-mean flow are very pronounced in the phenomena

  19. Comparison of a pulsatile blood pump and a peristaltic roller pump during hemoperfusion treatment in a canine model of paraquat poisoning.

    Science.gov (United States)

    Lee, Jung Chan; Park, Chan Young; Choi, Seong Wook; Kim, Jeong Chul; Lim, Ki Moo; Kim, Kyuseok; Jung, Sung Koo; Kwak, Young Ho; Shin, Sang Do; Jo, Ik Joon; Suh, Gil Joon; Min, Byoung Goo

    2008-07-01

    This study examined the treatment efficacy and the damage to the blood during hemoperfusion for treating paraquat poisoning using two blood pump mechanisms. Paraquat-poisoned animal models were prepared. A conventional hemodialysis machine, AK90, with a peristaltic roller pump and a cardiopulmonary support system, T-PLS, with a pulsatile blood pump were used during the animal experiments. A total of 12 dogs were treated with hemoperfusion using a charcoal column. Six dogs were treated with hemoperfusion and T-PLS, and the other six were treated with AK90. A paraquat dose of 30 mg/kg was administrated by an intravenous injection. Both pumps maintained blood flow rates of 125 mL/min measured by an ultrasonic flowmeter. For anticoagulation, heparin was administrated by an initial bolus (250 IU/kg) and a continuous injection (100 IU/kg/h). During the experiments, T-PLS and AK90 showed a similar toxin removal efficacy. Both devices decreased the plasma paraquat concentration to 10% of the initial dose within 4-h hemoperfusion. The two pumps showed similar hemolysis properties with acceptable levels. Although T-PLS was developed as a cardiopulmonary bypass system, it can also be used as a hemoperfusion treatment device. PMID:18638308

  20. Improvements in the technique of vascular perfusion-fixation employing a fluorocarbon-containing perfusate and a peristaltic pump controlled by pressure feedback

    DEFF Research Database (Denmark)

    Rostgaard, J; Qvortrup, K; Poulsen, Steen Seier

    1993-01-01

    elements. By adding oxygenated fluorocarbon to glutaraldehyde perfusate-fixatives, enough oxygen is made accessible for cellular respiration as well as for the oxygen-consuming chemical reactions of glutaraldehyde with the tissue. Data on anaesthesia, operative manoeuvres, mechanical components of the......A new improved technique for whole-body perfusion-fixation of rats and other small animals is described. The driving force is a peristaltic pump which is feedback regulated by a pressure transducer that monitors the blood-perfusion pressure in the left ventricle of the heart. The primary perfusate-fixative...... is composed of a blood substitute--13.3% oxygenated fluorocarbon FC-75--in 0.05 M cacodylate buffer (pH 7.4) with a 2% glutaraldehyde. The secondary perfusate-fixative is composed of 2% glutaraldehyde in 0.05 M cacodylate buffer (pH 7.4) with 20 mM CaCl2. A double-barrelled, self-holding cannula is...

  1. Cineradiography of the liquid bolus swallow. A study of the speed ot the bolus and peristaltic wave and of movement of the hyoid bone, larynx, and epiglottis

    International Nuclear Information System (INIS)

    In the evaluation of the dysphagic patient, radiology is crucial as a technique for monitoring morphology and function. In particular, high-speed cineradiography can reveal a variety of pharyngeal dysfunctions. However, in the literature and in practice the difference between normal and abnormal function is not always clear. This monography is based on high-speed cineradiographies of swallowing in 75 non-dysphagic volunteers and in 189 dysphagic patients. The purpose was to study whether differences in bolus volumes, patient position, age and gender had any effects on the following parameters: the speed of the peristaltic wave and apex of the liquid barium bolus, the length of movement and the movement pattern of the hyoid bone and larynx, and epiglottic function. The study disclosed that the speed of the bolus, the anterior-superior movement and net movement of the hyoid bone increased significantly with larger bolus volumes. The position of the individual in relation to gravity significantly influenced the speed of peristalsis. In most of the measured parameters there were no differences between non-dysphagic and dysphagic individuals expect for differences in the intrapersonal variations and in the anterior-superior movement of the hyoid bone. In patients with pharyngeal dysfunction the initial stage of the elevation of the larynx was significantly lower than in patients without dysfunction. The approximation of the thyroid cartilage to the hyoid bone was significantly greater in individuals with normal epiglottic function than in those with epiglottic dysmobility. It is suggested that abnormal speed of peristalsis may be a mild form of dysfunction. Measurements of the aforementioned speed and movements can be done if bolus volume, age and position of the patient, film speed and magnifications factors are known. Hypotheses concerning epiglottic function and central control of swallowing are proposed. (au)

  2. A New Concept of a Drug Delivery System with Improved Precision and Patient Safety Features

    OpenAIRE

    Florian Thoma; Frank Goldschmidtböing; Peter Woias

    2014-01-01

    This paper presents a novel dosing concept for drug delivery based on a peristaltic piezo-electrically actuated micro membrane pump. The design of the silicon micropump itself is straight-forward, using two piezoelectrically actuated membrane valves as inlet and outlet, and a pump chamber with a piezoelectrically actuated pump membrane in-between. To achieve a precise dosing, this micropump is used to fill a metering unit placed at its outlet. In the final design this metering unit will be ma...

  3. 流变学流体的蠕动传输:食道中食物块的运动模型%Peristaltic Transport of a Rheological Fluid:Model for Movement of Food Bolus Through Esophagus

    Institute of Scientific and Technical Information of China (English)

    J·C·密斯拉; S·麦蒂; 海治

    2012-01-01

    研究食道中蠕动传输的流体力学.对任意的波形和任意的管道长度,建立起流变学流体蠕动传输的数学模型.用粘性流体的Ostwald-de Waele幂定律,描述非Newton流体的流动特性.解析公式化模型,详细且精确地给出食物块在食道中蠕动传输相关的一些重要性质.分析中应用了润滑理论,本研究特别适合于Reynolds数不大的情况.将食道看作环形的管道,通过食道壁周期性的收缩来传输食物块.就单个波和周期性收缩一组波的传播,研究与传输过程有关变量的变化,如压力、流速、食物颗粒轨迹以及流量等.局部压力的变化,对流变指数n有着高度的敏感性.研究结果清晰地表明,食物块在食道中蠕动传输时,Newton流体或流变学流体构成的连续流体,以组合波传播比大间隔单波传播,传输效率要高得多.%Fluid mechanical peristaltic transport through esophagus had been of concern. A mathematical model had been developed with an aim to study the peristaltic transport of a rheo-logical fluid for arbitrary wave shapes and tube lengths. The Ostwald-de Waele power law of viscous fluid was considered here to depict the non-Newtonian behaviour of the fluid. The model was formulated and analyzed with the specific aim of exploring some important information concerning the movement of food bolus through the esophagus. The analysis had been carried out by using lubrication theory. The study was particularly suitable for cases where the Reynolds number was small. The esophagus was treated as a circular tube through which the transport of food bolus takes places by periodic contraction of the esophageal wall. Variation of different variables concerned with the transport phenomena such as pressure, flow velocity, particle trajectory and reflux were investigated for a single wave as well as for a train of periodic peristaltic waves. Locally variable pressure was seen to be highly sensitive to the flow index n

  4. 微极流体蠕动泵经由滑移边界管道输送的Stokes流动%Study on Stokes Flow of Micro-Polar Fluids by Peristaltic Pumping Through a Tube With Slip Boundary Condition

    Institute of Scientific and Technical Information of China (English)

    D·特里帕蒂; M·K·乔伯; P·K·古泊塔; 吴承平

    2011-01-01

    The Stokes flow of micro-polar fluids by peristaltic pumping through the cylindrical tube under the effect of slip boundary condition was studied. The motion of wall was governed by the sinusoidal wave equation. Analytical and numerical solutions for axial velocity, micro-polar vector, stream function, pressure gradient, friction force and mechanical efficiency were obtained by using the lubrication theory. The impacts of emerging parameters such as coupling number, micro-polar parameter and slip parameter on pumping characteristic, friction force and trapping phenomena were depicted graphically. Numerical computation infers that more pressure requires for peristaltic pumping when coupling number is large while opposite behavior is found for micro-polar parameter and the slip parameter. The size of trapped bolus reduces with coupling number and micro-polar parameter whereas it blows up with slip parameter.%计及管道边界条件滑移的影响,研究微极流体蠕动泵,经由圆柱形管道输运的Stokes流动.壁面运动的控制方程为正弦波方程.使用润滑理论,得到了轴向速度、微转动向量、流函数、压力梯度、摩擦力和机械效率的解析数值解.用图形表示出构成参数,如像耦合参数、微极参数和表征蠕流泵特性的滑移参数、摩擦力和俘获现象的影响.数值计算表明,当耦合参数较大时,需要蠕动泵的压力更大,而微极参数和滑移参数正相反.俘获团块的大小随耦合参数和微极参数的减小而缩小,而随滑移参数的增大而缩小.

  5. Analysis of flow characteristics in thermal-bubble actuated diffuser-nozzle valveless micropump%热汽泡驱动无阀微泵流动特性分析

    Institute of Scientific and Technical Information of China (English)

    潘良明; 岳万凤; 魏敬华; 陈德奇

    2013-01-01

    Based on the different flow resistance characteristic of diffuser/nozzle at the bubble growth and condensation stage, the flow characteristics of thermal-bubble actuated valveless micropump under different ratio of heating, driving frequency and diverging angle and different heating power are numerically investigated. Evaporation and condensation processes are accomplished by Volume of Fluid (VOF) multiphase flow model and User Defined Functions (UDF) interface. The results reveal that with the same ratio of heating time, the volume flow rate increases at first and then decreases with the increasing driving frequency. The micropump has a maximum flow rate of 5. 87 μL/min when the driving pulse is 250 Hz at 10% heating ratio. The volume flow rate increases at first then decreases with the enlarging diverging angle when keeping the aspect ratio constant, and it will reach the maximum when the diverging angle is 14°, and it has a higher pressure difference between the diffuser and the nozzle. The average velocity at the diffuser neck is always greater than the nozzle during the entire driving period, the pumping flow rate presents a trend of increasing at first and then flatting with the increasing heating power.%基于热汽泡生长和冷凝为微泵提供泵送压力源以及扩张管/收缩管流动阻力特性不同而实现差量流动的原理,对不同加热时间比例、驱动频率以及不同扩张角度及功率下热汽泡驱动无阀微泵流动特性进行了研究.蒸发和凝结过程通过流体体积函数(VOF)两相流模型及用户自定义函数(UDF)接口实现.结果表明:相同加热时间比例下,随着驱动频率增加,微泵泵送流量呈先增加后降低趋势;加热时间比例为10%,驱动频率为250 Hz时泵送流量达到最大值5.87 μL/min;在保持微泵扩张管/收缩管长宽比不变的情况下,泵送流量随扩张角也有先增后减的趋势,并在扩张角为14°时泵送流量达到最大,扩张管/收

  6. Design and Characterization of a Sensorized Microfluidic Cell-Culture System with Electro-Thermal Micro-Pumps and Sensors for Cell Adhesion, Oxygen, and pH on a Glass Chip

    Directory of Open Access Journals (Sweden)

    Sebastian M. Bonk

    2015-07-01

    Full Text Available We combined a multi-sensor glass-chip with a microfluidic channel grid for the characterization of cellular behavior. The grid was imprinted in poly-dimethyl-siloxane. Mouse-embryonal/fetal calvaria fibroblasts (MC3T3-E1 were used as a model system. Thin-film platinum (Pt sensors for respiration (amperometric oxygen electrode, acidification (potentiometric pH electrodes and cell adhesion (interdigitated-electrodes structures, IDES allowed us to monitor cell-physiological parameters as well as the cell-spreading behavior. Two on-chip electro-thermal micro-pumps (ETμPs permitted the induction of medium flow in the system, e.g., for medium mixing and drug delivery. The glass-wafer technology ensured the microscopic observability of the on-chip cell culture. Connecting Pt structures were passivated by a 1.2 μm layer of silicon nitride (Si3N4. Thin Si3N4 layers (20 nm or 60 nm were used as the sensitive material of the pH electrodes. These electrodes showed a linear behavior in the pH range from 4 to 9, with a sensitivity of up to 39 mV per pH step. The oxygen sensors were circular Pt electrodes with a sensor area of 78.5 μm2. Their sensitivity was 100 pA per 1% oxygen increase in the range from 0% to 21% oxygen (air saturated. Two different IDES geometries with 30- and 50-μm finger spacings showed comparable sensitivities in detecting the proliferation rate of MC3T3 cells. These cells were cultured for 11 days in vitro to test the biocompatibility, microfluidics and electric sensors of our system under standard laboratory conditions.

  7. 双压电驱动微泵泵膜的ANSYS仿真和结构优化分析%ANSYS Simulation and Structure Optimization of Double Piezoelectric Layers Driven Micro-Pump Membrane Structure

    Institute of Scientific and Technical Information of China (English)

    邓凯; 陈可娟

    2013-01-01

    A new kind of double piezoelectric layers driven pump membrane structure is introduced and the small deflection bending deformation theory pump membrane is analyzed.Using ANSYS software to establish the finite element model of the pump membrane,the static analysis and modal analysis is done.The pump membrane structure is optimized by using orthogonal test method.The results show that piezoelectric layer thickness influenced the deformation of pump membrane the most,and the driving voltage,pump membrane radius, electrode layer thickness,and basic level thickness followed.Pump membrane radius influenced the frequency of pump membrane the most,and the piezoelectric layer thickness, electrode layer thickness and basic level thickness followed.To optimize pump membrane structure can improve the efficiency of micro-pump, and the results provide the basis for the optimal design of micro-pump.%提出了一种新型的双压电泵膜结构,分析了泵膜小挠度弯曲形变理论.运用ANSYS软件建立了泵膜的有限元模型,并对泵膜进行了电压驱动静态分析和模态分析,通过正交试验法对泵膜结构进行了优化.分析表明,压电层厚度对膜片形变影响最大,其次依次是驱动电压、泵膜半径、电极层厚度、基层厚度;泵膜半径对膜片频率影响最大,其次依次是压电层厚度、电极层厚度、基层厚度;对泵膜结构进行优化,可以提高微泵的工作效率,研究结果为微泵的优化设计提供了依据.

  8. Application of RAGAZZINI Peristaltic Pump in the Production of New-process Mixiang Baijiu(Liquor)%RAGAZZINI蠕动泵在新工艺米香型白酒生产中的应用

    Institute of Scientific and Technical Information of China (English)

    朱旭平

    2015-01-01

    New-process Mixiang Baijiu(liquor) is the innovative program in Changle Distillery which won the 2nd Prize of Guangdong Light Industry Science and Technology and State Light Industry Science&Technology Excellent Prize. The difference between new-process produc-tion and traditional production were as follows:in the new process (raw materials in liquid&solid separation loose state), water was added di-rectly in cooked raw materials, then caky starter was added for saccharfication and fermentation in the same fermenter;in traditional process (raw materials in gelatinized state), cooked raw materials were saccharified in saccharifying tank at first, then water was added for fermentation in the fermenter. The use of new-process often induced pipe obstruction because the commonly-used pneumatic drive membrane pump drained liquid during the transportation of liquid&solid separation loose raw materials. Changle Distillery used peristaltic pump to settle such prob-lem, which could achieve continuous production and completely solve pipeline blocking from steam machine to fermenter.%新工艺米香型白酒生产线属长乐烧企业的创新项目,该项目获广东轻工科技二等奖、获国家轻工科技优秀奖。新工艺与传统工艺最大的区别在于,前者是将熟化后的原料直接加水、加曲输入发酵罐糖化、发酵同罐进行,后者是先将熟化的原料在糖化槽中糖化后加水再输入发酵罐。前者物料为液固松散分离状态,后者为糊化状态,因此常用的气动隔膜泵输送液固松散分离状态物料时就常常将液体抽走,造成管道阻塞。长乐烧酒业在新工艺生产线上利用蠕动泵实现了将熟化原料加水混合物料轻松输入发酵罐的目标,解决了管道阻塞问题,达到了连续生产目的,彻底改变了蒸饭机至发酵罐间物料自动输送的难题。

  9. Application of RAGAZZINI Peristaltic Pump in the Production of New-process Mixiang Baijiu(Liquor)%RAGAZZINI蠕动泵在新工艺米香型白酒生产中的应用

    Institute of Scientific and Technical Information of China (English)

    朱旭平

    2015-01-01

    新工艺米香型白酒生产线属长乐烧企业的创新项目,该项目获广东轻工科技二等奖、获国家轻工科技优秀奖。新工艺与传统工艺最大的区别在于,前者是将熟化后的原料直接加水、加曲输入发酵罐糖化、发酵同罐进行,后者是先将熟化的原料在糖化槽中糖化后加水再输入发酵罐。前者物料为液固松散分离状态,后者为糊化状态,因此常用的气动隔膜泵输送液固松散分离状态物料时就常常将液体抽走,造成管道阻塞。长乐烧酒业在新工艺生产线上利用蠕动泵实现了将熟化原料加水混合物料轻松输入发酵罐的目标,解决了管道阻塞问题,达到了连续生产目的,彻底改变了蒸饭机至发酵罐间物料自动输送的难题。%New-process Mixiang Baijiu(liquor) is the innovative program in Changle Distillery which won the 2nd Prize of Guangdong Light Industry Science and Technology and State Light Industry Science&Technology Excellent Prize. The difference between new-process produc-tion and traditional production were as follows:in the new process (raw materials in liquid&solid separation loose state), water was added di-rectly in cooked raw materials, then caky starter was added for saccharfication and fermentation in the same fermenter;in traditional process (raw materials in gelatinized state), cooked raw materials were saccharified in saccharifying tank at first, then water was added for fermentation in the fermenter. The use of new-process often induced pipe obstruction because the commonly-used pneumatic drive membrane pump drained liquid during the transportation of liquid&solid separation loose raw materials. Changle Distillery used peristaltic pump to settle such prob-lem, which could achieve continuous production and completely solve pipeline blocking from steam machine to fermenter.

  10. 基于微生物代谢成分的电化学多参数检测平台微泵设计∗%Design of Micropump for Parallel Multi-Parameter Detection of Microbial Metabolic Components Based on Electrochemical Platform

    Institute of Scientific and Technical Information of China (English)

    徐莹; 胡正添; 郭淼

    2015-01-01

    There are some crucial problems in design of parallel multi-parameter detection platform. This paper puts forward a parallel detection platform by electrochemistry method to analyze the antibiotic residue components in micro-bial metabolites,which quantitatively showed the influence of antibiotics on physiological environment,membrane ad-herence and metabolites of microorganism in real time. According to the required accuracy of antibiotic detection lim-it,the fluid volume for single detection should be controlled within 20 μL/min~100 μL/min. Therefore,this paper comprehensively analyzed the static field,dynamic field and fluid field of the micro pump by the finite element method to make sure that the precision and controllability of pump design meet the measurement requirements,which was the key point in the detection platform. Results showed that the micro-pump flow rate was 52.864μL/min when the pump was driven by 20 Hz,±40 V AC voltage,and the relations between frequency and voltage to control the real-time change of flow rate were also discussed. Moreover,the passive valve micro pump was further analyzed on mechanical characteristics and the optimized pump fix end size(0.4 mm×0.5 mm). Finally,verified experiment of the obtained simulation data for flow rate compared with PSS20 commercial micro-pump was done with the error rate of 6. 7%, which proved the feasibility and accuracy of the finite element method,and provided a good reference for the design and improvement of micro-pump as well as the parallel multi-parameter detection platform.%本文提出一种基于抗生素作用下的微生物膜阻抗及代谢液微量残留物分析的电化学并行检测平台,从量化角度实时反映抗生素对微生物的膜贴附变化及代谢成分的影响。根据现有抗生素电化学检测单元的检测精度,待测生理溶液的进样体积需控制在20μL/min~100μL/min,因此本文针对平台中的关键部分———微泵单元采用有限元

  11. Design of Micropump for Parallel Multi-Parameter Detection of Microbial Metabolic Components Based on Electrochemical Platform%基于微生物代谢成分的电化学多参数检测平台微泵设计∗

    Institute of Scientific and Technical Information of China (English)

    徐莹; 胡正添; 郭淼

    2015-01-01

    There are some crucial problems in design of parallel multi-parameter detection platform. This paper puts forward a parallel detection platform by electrochemistry method to analyze the antibiotic residue components in micro-bial metabolites,which quantitatively showed the influence of antibiotics on physiological environment,membrane ad-herence and metabolites of microorganism in real time. According to the required accuracy of antibiotic detection lim-it,the fluid volume for single detection should be controlled within 20 μL/min~100 μL/min. Therefore,this paper comprehensively analyzed the static field,dynamic field and fluid field of the micro pump by the finite element method to make sure that the precision and controllability of pump design meet the measurement requirements,which was the key point in the detection platform. Results showed that the micro-pump flow rate was 52.864μL/min when the pump was driven by 20 Hz,±40 V AC voltage,and the relations between frequency and voltage to control the real-time change of flow rate were also discussed. Moreover,the passive valve micro pump was further analyzed on mechanical characteristics and the optimized pump fix end size(0.4 mm×0.5 mm). Finally,verified experiment of the obtained simulation data for flow rate compared with PSS20 commercial micro-pump was done with the error rate of 6. 7%, which proved the feasibility and accuracy of the finite element method,and provided a good reference for the design and improvement of micro-pump as well as the parallel multi-parameter detection platform.%本文提出一种基于抗生素作用下的微生物膜阻抗及代谢液微量残留物分析的电化学并行检测平台,从量化角度实时反映抗生素对微生物的膜贴附变化及代谢成分的影响。根据现有抗生素电化学检测单元的检测精度,待测生理溶液的进样体积需控制在20μL/min~100μL/min,因此本文针对平台中的关键部分———微泵单元采用有限元

  12. A thermopneumatic micropump based on micro-engineering techniques

    OpenAIRE

    Pol, van der, P.; Lintel, van, H.T.G.; Elwenspoek, M; Fluitman, J.H.J.

    1990-01-01

    The design, working principle and realization of an electro-thermopneumatic liquid pump based on micro-engineering techniques are described. The pump, which is of the reciprocating displacement type, comprises a pump chamber, a thin silicon pump membrane and two silicon check valves to direct the flow. The dynamic pressure of an amount of gas contained in a cavity, controlled by resistive heating, actuates the pump membrane. The cavity, chambers, channels and valves are realized in silicon wa...

  13. Deterministic transport of particles in a micro-pump

    CERN Document Server

    Beltrame, Philippe; Hänggi, Peter

    2012-01-01

    We study the drift of suspended micro-particles in a viscous liquid pumped back and forth through a periodic lattice of pores (drift ratchet). In order to explain the particle drift observed in such an experiment, we present an one-dimensional deterministic model of Stokes' drag. We show that the stability of oscillations of particle is related to their amplitude. Under appropriate conditions, particles may drift and two mechanisms of transport are pointed out. The first one is due to an spatio-temporal synchronization between the fluid and particle motions. As results the velocity is locked by the ratio of the space periodicity over the time periodicity. The direction of the transport may switch by tuning the parameters. Noteworthy, its emergence is related to a lattice of 2-periodic orbits but not necessary to chaotic dynamics. The second mechanism is due to an intermittent bifurcation and leads to a slow transport composed by long time oscillations following by a relative short transport to the next pore. ...

  14. Micropump and venous valve by micro stereo lithography

    Science.gov (United States)

    Varadan, Vijay K.; Varadan, Vasundara V.

    2000-06-01

    Micro Stereo Lithography (MSL) is a poor man's LIGA for fabricating high aspect ratio MEMS devices in UV curable semiconducting polymers using either two computer-controlled low inertia galvanometric mirrors with the aid of focusing lens or an array of optical fibers. For 3D MEMS devices, the polymers need to have conductive and possibly piezoelectric or ferroelectric properties. Such polymers are being developed at Penn State resulting in microdevices for fluid and drug delivery. Applications may include implanted medical delivery system, artificial heart valves, chemical and biological instruments, fluid delivery in engines, pump coolants and refrigerants for local cooling of electronic components. With the invention of organic thin film transistor, now it is possible to fabricate 3D polymeric MEMS devices with built-in-electronics similar to silicon based microelectronics.

  15. Single-pulse dynamics and flow rates of inertial micropumps

    CERN Document Server

    Govyadinov, A N; Markel, D P; Torniainen, E D

    2015-01-01

    Bubble-driven inertial pumps are a novel method of moving liquids through microchannels. We combine high-speed imaging, computational fluid dynamics (CFD) simulations and an effective one-dimensional model to study the fundamentals of inertial pumping. Single-pulse flow through 22 x 17 um2 U-shaped channels containing 4-um polystyrene tracer beads has been imaged with a high-speed camera. The results are used to calibrate the CFD and one-dimensional models to extract an effective bubble strength. Then the frequency dependence of inertial pumping is studied both experimentally and numerically. The pump efficiency is found to gradually decrease once the successive pulses start to overlap in time.

  16. [Intensified insulin therapy and insulin micro-pumps during pregnancy].

    Science.gov (United States)

    Galuppi, V

    1994-06-01

    Before conception and during pregnancy in diabetic patients, every possible effort should be made in order to obtain a good, if not perfect, metabolic control and to warrant maternal and fetal health. Multiple daily injections are required to achieve a very strict glucose regulation in pregnant patients with insulin-dependent diabetes mellitus. The most usual intensive insulin administration patterns require 3 premeal doses of short-acting insulin and 1 (at bedtime) or 2 (one in the morning and one at bedtime) injections of intermediate or slow-acting insulin. As an alternative choice, insulin pumps allow a continuous subcutaneous infusion with short-acting insulin according to a basal rate which cover the insulin need during the night and between meals. Premeal and presnack surges of insulin are administrated by the patient herself. Home glucose monitoring must be used to adjust insulin doses. Target glucose levels every diabetic pregnant woman should try to achieve are lower than in non-pregnant women: fasting glycaemia should be below 100 mg/dl, 1 hour post-prandial value below 140 mg/dl and 2 hour post-prandial level below 120 mg/dl. The stricter the control and treatment goals are, the more frequently hypoglycaemia may occur. Hypoglycaemia may be harmful especially for patients with severe diabetic complications and may affect the fetus. Therefore, every pregnant diabetic woman should receive individualized treatment and glycaemic goals according to her clinical features, her compliance and her social and cultural background. PMID:7968932

  17. Rotational Efficiency of Photo-Driven Archimedes Screws for Micropumps

    Directory of Open Access Journals (Sweden)

    Chih-Lang Lin

    2015-06-01

    Full Text Available In this study, we characterized the rotational efficiency of the photo-driven Archimedes screw. The micron-sized Archimedes screws were fabricated using the two-photon polymerization technique. Free-floating screws trapped by optical tweezers align in the laser irradiation direction and rotate spontaneously. The influences of the screw pitch and the number of screw blades have been investigated in our previous studies. In this paper, the blade thickness and the central rod of the screw were further investigated. The experimental results indicate that the blade thickness contributes to rotational stability, but not to rotational speed, and that the central rod stabilizes the rotating screw but is not conducive to rotational speed. Finally, the effect of the numerical aperture (NA of the optical tweezers was investigated through a demonstration. The NA is inversely proportional to the rotational speed.

  18. Rotational Efficiency of Photo-Driven Archimedes Screws for Micropumps

    OpenAIRE

    Chih-Lang Lin; Yu-Sheng Lin; Baldeck, Patrice L.

    2015-01-01

    In this study, we characterized the rotational efficiency of the photo-driven Archimedes screw. The micron-sized Archimedes screws were fabricated using the two-photon polymerization technique. Free-floating screws trapped by optical tweezers align in the laser irradiation direction and rotate spontaneously. The influences of the screw pitch and the number of screw blades have been investigated in our previous studies. In this paper, the blade thickness and the central rod of the screw were ...

  19. Fabrication of a peristaltic micro pump with novel cascaded actuators

    International Nuclear Information System (INIS)

    This paper presents the fabrication of an all-PDMS (polydimethylsiloxane) micro pump with novel cascaded actuators as dynamic valves. The micro pump consists of three pneumatic actuators in series and a micro fluidic channel connecting two fluidic inlet and outlet ports. The three-layer bonded pump structure is fabricated through a typical moulding process of PDMS and a simple heating process for the PDMS-to-PDMS bonding. The total size of the micro pump is 5 mm × 5 mm. The dynamic valve pattern of the single actuator is observed under various operational conditions of the square-wave input signal for the estimation of its volume stroke. The maximum volume stroke of the pneumatic actuator for liquid is about 85% of the volume of the liquid chamber. Three types of liquid-pumping tests are performed for characterization of the micro pump such as backpressure, frequency and viscous liquids. The flow rate of the de-ionized (DI) water is about 73.9 nl min−1 at zero backpressure. As the hydraulic difference between inlet and outlet ports increases, the flow rate gradually decreases. In the case of the frequency responses, the micro pump has the maximum flow rate of the DI water at 2 Hz. The viscosity-dependent flow rate of the working fluids is also observed

  20. Evaluation of peristaltic micromixers for highly integrated microfluidic systems

    Science.gov (United States)

    Kim, Duckjong; Rho, Hoon Suk; Jambovane, Sachin; Shin, Soojeong; Hong, Jong Wook

    2016-03-01

    Microfluidic devices based on the multilayer soft lithography allow accurate manipulation of liquids, handling reagents at the sub-nanoliter level, and performing multiple reactions in parallel processors by adapting micromixers. Here, we have experimentally evaluated and compared several designs of micromixers and operating conditions to find design guidelines for the micromixers. We tested circular, triangular, and rectangular mixing loops and measured mixing performance according to the position and the width of the valves that drive nanoliters of fluids in the micrometer scale mixing loop. We found that the rectangular mixer is best for the applications of highly integrated microfluidic platforms in terms of the mixing performance and the space utilization. This study provides an improved understanding of the flow behaviors inside micromixers and design guidelines for micromixers that are critical to build higher order fluidic systems for the complicated parallel bio/chemical processes on a chip.

  1. Esophageal contractions in type 3 achalasia esophagus: simultaneous or peristaltic?

    Science.gov (United States)

    Kim, Tae Ho; Patel, Nirali; Ledgerwood-Lee, Melissa; Mittal, Ravinder K

    2016-05-01

    Absence of peristalsis and impaired relaxation of lower esophageal sphincter are the hallmarks of achalasia esophagus. Based on the pressurization patterns, achalasia has been subdivided into three subtypes. The goal of our study was to evaluate the esophageal contraction pattern and bolus clearance in type 3 achalasia esophagus. High-resolution manometry (HRM) recordings of all patients diagnosed with achalasia esophagus in our center between the years 2011 and 2013 were reviewed. Recordings of 36 patients with type 3 achalasia were analyzed for the characteristics of swallow-induced "simultaneous esophageal contraction." The HRM impedance recordings of 14 additional patients with type 3 achalasia were analyzed for bolus clearance from the impedance recording. Finally, the HRM impedance along with intraluminal ultrasound imaging was conducted in six patients to further characterize the simultaneous esophageal contractions. Among 187 achalasia patients, 30 were type 1, 121 type 2, and 36 type 3. A total of 434 swallows evaluated in type 3 achalasia patients revealed that 95% of the swallow-induced contractions met criteria for simultaneous esophageal contraction, based on the onset of contraction. Interestingly, the peak and termination of the majority of simultaneous esophageal contractions were sequential. The HRM impedance revealed that 94% of the "simultaneous contractions" were associated with complete bolus clearance. Ultrasound image analysis revealed that baseline muscle thickness of patients in type 3 achalasia is larger than normal but the pattern of axial shortening is similar to that in normal subjects. The majority of esophageal contractions in type 3 achalasia are not true simultaneous contractions because the peak and termination of contraction are sequential and they are associated with complete bolus clearance. PMID:26950858

  2. Evaluation of peristaltic micromixers for highly integrated microfluidic systems.

    Science.gov (United States)

    Kim, Duckjong; Rho, Hoon Suk; Jambovane, Sachin; Shin, Soojeong; Hong, Jong Wook

    2016-03-01

    Microfluidic devices based on the multilayer soft lithography allow accurate manipulation of liquids, handling reagents at the sub-nanoliter level, and performing multiple reactions in parallel processors by adapting micromixers. Here, we have experimentally evaluated and compared several designs of micromixers and operating conditions to find design guidelines for the micromixers. We tested circular, triangular, and rectangular mixing loops and measured mixing performance according to the position and the width of the valves that drive nanoliters of fluids in the micrometer scale mixing loop. We found that the rectangular mixer is best for the applications of highly integrated microfluidic platforms in terms of the mixing performance and the space utilization. This study provides an improved understanding of the flow behaviors inside micromixers and design guidelines for micromixers that are critical to build higher order fluidic systems for the complicated parallel bio/chemical processes on a chip. PMID:27036809

  3. A peristaltic pump driven 89Zr separation module

    DEFF Research Database (Denmark)

    Siikanen, J.; Peterson, M.; Tran, T.;

    2012-01-01

    To facilitate the separation of 89Zr produced in yttrium foils, an automated separation module was designed and assembled. The module separates more than 85% of produced 89Zr - activity in 3 g foils in less than 90 min. About 10 % remains in the dissolving vial. The quality of the separated 89Zr...

  4. A New Concept of a Drug Delivery System with Improved Precision and Patient Safety Features

    Directory of Open Access Journals (Sweden)

    Florian Thoma

    2014-12-01

    Full Text Available This paper presents a novel dosing concept for drug delivery based on a peristaltic piezo-electrically actuated micro membrane pump. The design of the silicon micropump itself is straight-forward, using two piezoelectrically actuated membrane valves as inlet and outlet, and a pump chamber with a piezoelectrically actuated pump membrane in-between. To achieve a precise dosing, this micropump is used to fill a metering unit placed at its outlet. In the final design this metering unit will be made from a piezoelectrically actuated inlet valve, a storage chamber with an elastic cover membrane and a piezoelectrically actuated outlet valve, which are connected in series. During a dosing cycle the metering unit is used to adjust the drug volume to be dispensed before delivery and to control the actually dispensed volume. To simulate the new drug delivery concept, a lumped parameter model has been developed to find the decisive design parameters. With the knowledge taken from the model a drug delivery system is designed that includes a silicon micro pump and, in a first step, a silicon chip with the storage chamber and two commercial microvalves as a metering unit. The lumped parameter model is capable to simulate the maximum flow, the frequency response created by the micropump, and also the delivered volume of the drug delivery system.

  5. Finite element computation of electromechanical micro-switches and micro-pump actuators

    OpenAIRE

    Lejeune, Jean-Michel; Rochus, Véronique; Golinval, Jean-Claude

    2004-01-01

    a new methodology to model the electromechanical behavior of microscale system components is presented. The original approach proposed in this paper is based on a unified FE formulation of the strong electromechanical interaction problem, in which both the electric and the mechanical fields are considered simultaneously. To this aim, finite elements based on the Mindlin shell theory are implemented. In order to illustrate the proposed methodology, numerical results are presented on the mod...

  6. Particle and droplet dynamics and separation in AC electro-osmotic micropumps

    International Nuclear Information System (INIS)

    Typical tasks in life--sciences are the transport of small amounts of liquids as well as the segregation of suspended biological cells or particles in the microfluidic environment. In the last decade alternating-current electro-osmotic (ACEO) pumping has been found to be an effective means for transporting conductive fluids in microfluidic channels. The ACEO pumping channel is characterized by its configuration of periodic interdigitated electrode fingers on the channel bottom. If a harmonic voltage is applied, an electric double layer develops adjacent to the electrodes that electrically screens the applied potential. The motion of the charged surface layer due to the remaining electric field results in a net flow in the channel. This work proposes to use the ACEO pump not only for the transport of liquids but also for the systematic manipulation and separation of immersed particles. In order to achieve this an extensive study of the relevant forces and dynamics of particles and droplets in the resulting electro-kinetic channel flow is done. This work therefore analyzes the electric and the flow field by means of the finite element method and investigates the size and density dependent particle motion as a function of magnitude and frequency of the applied voltage. Furthermore, the deformation of droplets in the electrokinetic flow is investigated. Their motion is therefore analyzed by means of three-dimensional finite element computations of the respective two-phase flow, where surface tension forces and electrical stresses on the interface between droplet and carrier fluid are regarded. In the course of this work it is shown, that suspended particles and droplets are influenced by the interplay of viscous fluid drag, gravitation, surface tension and dielectrophoretic forces. Therein, the significant dependance of these forces on the particle properties allows for the separation with respect to mass--density and size. Based on this knowledge, channel designs are proposed which enable classical longitudinal separation by means of selective particle mobility in the channel. Devices are designed that separate immersed particles in terms of opposing motion directions. Furthermore, by inclining the electrodes, a continuous lateral separation is achieved, where different particle classes are sorted over the channel width. (author)

  7. A NEW TYPE OF MICROPUMP DRIVEN BY A LOW ELECTRIC VOLTAGE

    Institute of Scientific and Technical Information of China (English)

    Guo Shuxiang; ASAKA Kinji

    2004-01-01

    In this paper, we propose a new prototype model of a micro pump using ICPF (Ionic Conducting Polymer Film) actuator as the servo actuator. This micro pump consists of two active oneway valves that make use of the same ICPF actuator. The overall size of this micro pump prototype is 12mm in diameter and 20 mm in length. The actuating mechanism is as follows: (1) The ICPF actuator as the diaphragm is bent into anode side by application of electricity. Then the volume of the pump chamber increases, resulting in the inflow of liquid from the inlet to the chamber. (2) By changing the current direction, the volume of the pump chamber decreases, resulting in the liquid flow from the chamber to the outlet. (3) The ICPF actuator is put on a sine voltage, the micro pump provides liquid flow from the inlet to the outlet continuously. Characteristic of the micro pump is measured. The experimental results indicate that the micro pump has the satisfactory responses.

  8. Development of highly integrated magetically and electrostatically actuated micropumps : LDRD 64709 final report.

    Energy Technology Data Exchange (ETDEWEB)

    Sosnowchik, Brian D. (Pennsylvania State University, University Park, PA); Galambos, Paul C.; Hendrix, Jason R. (Florida State University, Tallahassee, FL); Zwolinski, Andrew (Florida State University, Tallahassee, FL)

    2003-12-01

    The pump and actuator systems designed and built in the SUMMiT{trademark} process, Sandia's surface micromachining polysilicon MEMS (Micro-Electro-Mechanical Systems) fabrication technology, on the previous campus executive program LDRD (SAND2002-0704P) with FSU/FAMU (Florida State University/Florida Agricultural and Mechanical University) were characterized in this LDRD. These results demonstrated that the device would pump liquid against the flow resistance of a microfabricated channel, but the devices were determined to be underpowered for reliable pumping. As a result a new set of SUMMiT{trademark} pumps with actuators that generate greater torque will be designed and submitted for fabrication. In this document we will report details of dry actuator/pump assembly testing, wet actuator/pump testing, channel resistance characterization, and new pump/actuator design recommendations.

  9. Remotely powered self-propelling particles and micropumps based on miniature diodes

    Science.gov (United States)

    Chang, Suk Tai; Paunov, Vesselin N.; Petsev, Dimiter N.; Velev, Orlin D.

    2007-03-01

    Microsensors and micromachines that are capable of self-propulsion through fluids could revolutionize many aspects of technology. Few principles to propel such devices and supply them with energy are known. Here, we show that various types of miniature semiconductor diodes floating in water act as self-propelling particles when powered by an external alternating electric field. The millimetre-sized diodes rectify the voltage induced between their electrodes. The resulting particle-localized electro-osmotic flow propels them in the direction of either the cathode or the anode, depending on their surface charge. These rudimentary self-propelling devices can emit light or respond to light and could be controlled by internal logic. Diodes embedded in the walls of microfluidic channels provide locally distributed pumping or mixing functions powered by a global external field. The combined application of a.c. and d.c. fields in such devices allows decoupling of the velocity of the particles and the liquid and could be used for on-chip separations.

  10. Micropump Fuel Mix Control for Novel Miniature Direct Methanol Fuel Cells Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Energies and Power Densities of Direct Methanol Fuel Cells (DMFCs) are limited by the size and weight associated with the liquid pump, which must circulate the...

  11. Highly Efficient and Robust Micropump for Small Spacecraft Thermal Control Project

    Data.gov (United States)

    National Aeronautics and Space Administration — With the introduction of low-cost, small, rapidly configurable spacecraft, the need for robust, versatile, readily deployable, and easily ground-testable thermal...

  12. Characterization of flowreversal in anodically bonded glass-based AC electrokinetic micropumps

    DEFF Research Database (Denmark)

    Gregersen, Misha Marie; Olesen, Laurits Højgaard; Brask, Anders;

    2007-01-01

    Microfluidic chips have been fabricated to study electrokinetic pumping generated by a low voltage AC signal applied to an asymmetric electrode array. A measurement procedure has been established and followed carefully resulting in a high degree of reproducibility of the measurements. Depending on...

  13. Highly Capable Micropump-fed Propulsion System for Proximity Operations, Landing and Ascent Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Flight Works is proposing to expand its work in micro-gear-pumps for propulsion applications in order to provide a highly capable propulsion and attitude control...

  14. MHD peristaltic motion of Johnson-Segalman fluid in a channel with compliant walls

    Energy Technology Data Exchange (ETDEWEB)

    Hayat, T. [Department of Mathematics, Quaid-i-Azam University, Islamabad 44000 (Pakistan)], E-mail: t_pensy@hotmail.com; Javed, Maryiam [Department of Mathematics, Quaid-i-Azam University, Islamabad 44000 (Pakistan); Asghar, S. [Department of Mathematical Sciences, COMSATS Institute of Information Technology, H-8, Islamabad (Pakistan)

    2008-07-21

    A mathematical model for magnetohydrodynamic (MHD) flow of a Johnson-Segalman fluid in a channel with compliant walls is analyzed. The flow is engendered due to sinusoidal waves on the channel walls. A series solution is developed for the case in which the amplitude ratio is small. Our computations show that the mean axial velocity of a Johnson-Segalman fluid is smaller than that of a viscous fluid. The variations of various interesting dimensionless parameters are graphed and discussed.

  15. Peristaltic Motion of Power-Law Fluid with Heat and Mass Transfer

    Institute of Scientific and Technical Information of China (English)

    T.Hayat; S.Hina; Awatif A.Hendi

    2011-01-01

    @@ The effects of wall properties and heat and mass transfer on the peristalsis in a power-law fluid are investigated.The solutions for the stream function, temperature, concentration and heat transfer coefficient are obtained.The axial velocity, temperature and mass concentration are studied for different emerging parameters.

  16. Peristaltic motion of a Johnson-Segalman fluid in a planar channel

    Directory of Open Access Journals (Sweden)

    Hayat T.

    2003-01-01

    Full Text Available This paper is devoted to the study of the two-dimensional flow of a Johnson-Segalman fluid in a planar channel having walls that are transversely displaced by an infinite, harmonic travelling wave of large wavelength. Both analytical and numerical solutions are presented. The analysis for the analytical solution is carried out for small Weissenberg numbers. (A Weissenberg number is the ratio of the relaxation time of the fluid to a characteristic time associated with the flow. Analytical solutions have been obtained for the stream function from which the relations of the velocity and the longitudinal pressure gradient have been derived. The expression of the pressure rise over a wavelength has also been determined. Numerical computations are performed and compared to the perturbation analysis. Several limiting situations with their implications can be examined from the presented analysis.

  17. Multi-channel peristaltic pump for microfluidic applications featuring monolithic PDMS inlay

    DEFF Research Database (Denmark)

    Skafte-Pedersen, Peder; Sabourin, David; Dufva, Martin;

    2009-01-01

    flow. Both use a monolithic PDMS pumping inlay featuring three-dimensional geometries favourable to pumping applications and 12 wholly integrated circular channels. Flow rates in the sub-µL min-1 to µL min-1 range were obtained. Channel-to-channel flow rate variability was comparable to a commercial...

  18. Fabrication of magnetoresistive actuators using rare-earth (Tb, Sm)-Fe thin films

    Science.gov (United States)

    Honda, T.; Arai, K. I.; Yamaguchi, M.

    1994-11-01

    A new concept is proposed for the microactuation based upon magnetostriction. Magnetostrictive bimorph cantilever actuators and a traveling machine, composed of the magnetostrictive amorphous Tb-Fe and Sm-Fe thin films on a polymide substrate, were fabricated. These actuators moved without power supply cables. The 3-mm-long cantilever actuator exhibited the large deflection above 100 microns in as low a magnetic field as 300 Oe and above 500 microns at resonant frequency in an alternating magnetic field of 300 Oe. Such unique characteristics suggest that magnetostriction is useful as the driving force of the microactuator.

  19. Mechano-optical switching in a mems integrated photonic crystal slab waveguide

    NARCIS (Netherlands)

    Abdulla, S.M.C.; Kauppinen, L.J.; Dijkstra, M.A.; Berenschot, J.W.; Boer, de M.J.; Ridder, de R.M.; Krijnen, G.J.M.

    2011-01-01

    A photonic crystal slab waveguide (PhC-WG) with an integrated MEMS bimorph cantilever actuator has been successfully fabricated using deep UV lithography and surface micromaching techniques. The cantilever is equipped with tips that are self-aligned with respect to the holes of the PhC-WG such that

  20. Electrohydrodynamic pumping in microsystems

    Energy Technology Data Exchange (ETDEWEB)

    Ramos, Antonio, E-mail: ramos@us.es [Deptartamento de Electronica y Electromagnetismo, Universidad de Sevilla, Avenida Reina Mercedes s/n, 41012-Sevilla (Spain)

    2011-06-23

    The physical principles behind the electrohydrodynamic (EHD) actuation in microsystems is presented by reviewing five different EHD micropumps. These are classified into two groups: micropumps that exert electric forces in the liquid bulk and micropumps that exert forces in the diffuse double layer. This review of five EHD micropumps allows us to analyse the EHD actuation ranging from very insulating liquids to electrolytic solutions.

  1. Design and Analysis of a High Force, Low Voltage and High Flow Rate Electro-Thermal Micropump

    Directory of Open Access Journals (Sweden)

    Ghader Yosefi

    2014-12-01

    Full Text Available This paper presents the design and simulation of an improved electro-thermal micromachined pump for drug delivery applications. Thermal actuators, which are a type of Micro Electro Mechanical system (MEMS device, are highly useful because of their ability to deliver with great force and displacement. Thus, our structure is based on a thermal actuator that exploits the Joule heating effect and has been improved using the springy length properties of MEMS chevron beams. The Joule heating effect results in a difference in temperature and therefore displacement in the beams (actuators. Simulation results show that a maximum force of 4.4 mN and a maximum flow rate of 16 μL/min can be obtained by applying an AC voltage as low as 8 V at different frequencies ranging from 1 to 32 Hz. The maximum temperature was a problem at the chevron beams and the center shaft. Thus, to locally increase the temperature of the chevron beams alone and not that of the pumping diaphragm: (1 The air gaps 2 μm underneath and above the device layer were optimized for heat transfer. (2 Release holes and providing fins were created at the center shaft and actuator, respectively, to decrease the temperature by approximately 10 °C. (3 We inserted and used a polymer tube to serve as an insulator and eliminate leakage problems in the fluidic channel.

  2. Design and Analysis of a High Force, Low Voltage and High Flow Rate Electro-Thermal Micropump

    OpenAIRE

    Ghader Yosefi; Sattar Mirzakuchaki; Farshid Raissi; Saeid Afrang

    2014-01-01

    This paper presents the design and simulation of an improved electro-thermal micromachined pump for drug delivery applications. Thermal actuators, which are a type of Micro Electro Mechanical system (MEMS) device, are highly useful because of their ability to deliver with great force and displacement. Thus, our structure is based on a thermal actuator that exploits the Joule heating effect and has been improved using the springy length properties of MEMS chevron beams. The Joule heating effec...

  3. An all-polymer micropump based on the conductive polymer poly(3,4-ethylenedioxythiophene) and a polyurethane channel system

    DEFF Research Database (Denmark)

    Hansen, Thomas Steen; West, Keld; Hassager, Ole;

    2007-01-01

    An all-polymer micropunlp was realized using the conductive polymer poly(3,4-ethylenedioxythiophene) (PEDT) as the active cODlponent. The pUlnping effect originated fronl an ac potential applied to an aSylnlnetric array of interdigitat.ed electrodes. The PEDT electrodes were fabricated using...... of t.he conducting polylner electrodes by an insulating polYlTIer layer prevented electrode break-down at the cost of puolping efficiency. Continuous punlping for 40 nlin at 20 fJ..,m s-l without detectable pump degradation was delTIOnstrated in this configuration....

  4. Isolation of Individual Egg Cells and Zygotes in Alstroemeria Followed by Manual Selection with a Microcapillary-connected Micropump

    OpenAIRE

    Hoshino, Yoichiro; MURATA, Naho; Shinoda, Koichi

    2006-01-01

    Aims: To develop a procedure for isolating living egg cells and zygotes from Alstroemeria ovules. Scope: We attempted to isolate egg cells and zygotes from the ovules of Alstroemeria aurea. The ovules were histologically observed using a clearing procedure which revealed the localization and sizes of the embryo sacs and egg apparatus within the ovules. For the isolation of egg cells, ovules were cut into sections with a surgical blade and treated with an enzyme solution. Subsequently, these o...

  5. A surface acoustic wave-driven micropump for particle uptake investigation under physiological flow conditions in very small volumes

    Directory of Open Access Journals (Sweden)

    Florian G. Strobl

    2015-02-01

    Full Text Available Static conditions represent an important shortcoming of many in vitro experiments on the cellular uptake of nanoparticles. Here, we present a versatile microfluidic device based on acoustic streaming induced by surface acoustic waves (SAWs. The device offers a convenient method for introducing fluid motion in standard cell culture chambers and for mimicking capillary blood flow. We show that shear rates over the whole physiological range in sample volumes as small as 200 μL can be achieved. A precise characterization method for the induced flow profile is presented and the influence of flow on the uptake of Pt-decorated CeO2 particles by endothelial cells (HMEC-1 is demonstrated. Under physiological flow conditions the particle uptake rates for this system are significantly lower than at low shear conditions. This underlines the vital importance of the fluidic environment for cellular uptake mechanisms.

  6. Experimental application of a vibration absorber in structural vibration reduction using tunable fluid mass driven by micropump

    Science.gov (United States)

    Lee, Chun-Ying; Chen, Chun-Yuan

    2015-07-01

    A new design of tuned mass damper was proposed in this study to reduce the structural vibration of a machine platform subjected to varying excitation frequency, e.g. disturbance from the unbalance mass of motor in different rotational speeds. The absorber mass was changed by pumping of fluid between the liquid chambers of the vibration absorber. With the stiffness remained unchanged, the absorber's natural frequency could be tuned accordingly. Thus, reduction in machine vibration could be obtained by tuning the natural frequency of the absorber according to the frequency of external harmonic disturbance. Firstly, the variations of natural frequency and damping ratio of the absorber with different tuned masses were measured experimentally. The natural frequency results showed that the adjustable ranges for the first two modes could all reach more than 30%. Then, the absorber was installed on a machine platform and its performance was investigated under external disturbance at the natural frequency of the platform. It was found that, due to the effect of damping increase originated from the fluid sloshing inside liquid chamber, the vibration reduction effect from the absorber was limited. To improve this situation, we added a horizontal separation panel inside the liquid chambers, and the experimental results showed that the liquid sloshing was alleviated, and effectively reduced the damping ratio of absorber. Thus, the system became more stable and the control efficiency was effectively improved.

  7. A feasibility study on using inkjet technology, micropumps, and MEMs as fuel injectors for bipropellant rocket engines

    OpenAIRE

    Glynne-Jones, Peter; Coletti, Michele; White, Neil M; Gabriel, Stephen; Bramanti, Cristina

    2008-01-01

    Control over drop size distributions, injection rates, and geometrical distribution of fuel and oxidizer sprays in bi-propellant rocket engines has the potential to produce more efficient, more stable, less polluting rocket engines. This control also offers the potential of an engine that can be throttled, working efficiently over a wide range of output thrusts. Inkjet printing technologies, MEMS fuel atomizers, and piezoelectric injectors similar in concept to those used in diesel engines ar...

  8. Buttressing staples with cholecyst-derived extracellular matrix (CEM) reinforces staple lines in an ex vivo peristaltic inflation model.

    LENUS (Irish Health Repository)

    Burugapalli, Krishna

    2008-11-01

    Staple line leakage and bleeding are the most common problems associated with the use of surgical staplers for gastrointestinal resection and anastomotic procedures. These complications can be reduced by reinforcing the staple lines with buttressing materials. The current study reports the potential use of cholecyst-derived extracellular matrix (CEM) in non-crosslinked (NCEM) and crosslinked (XCEM) forms, and compares their mechanical performance with clinically available buttress materials [small intestinal submucosa (SIS) and bovine pericardium (BP)] in an ex vivo small intestine model.

  9. Effect of subcutaneous butylscopolamine administration in the reduction of peristaltic artifacts in 1.5-T MR fast abdominal examinations

    International Nuclear Information System (INIS)

    In abdominal MR imaging, ghost artifacts from noncyclic bowel movements can reduce the quality of the images. Although pharmacologic suppression of motion is effective, no study has being conducted to analyze the influence of drug motion suppression on fast breath-hold 1.5-T examinations of the upper abdomen. A prospective, randomized, double-blind trial was conducted in 50 patients. Patients were randomly distributed into two groups: The control group received only an oral solution, whereas the other group received the oral solution plus a subcutaneous injection of 20 mg of butylscopolamine 10 min before the MR examination. Breath-hold T1-weighted gradient-recalled-echo (GRE) MR images were obtained in a 1.5-T superconductive unit. Quantitative image analysis was performed with region-of-interest (ROI) measurements of the signal intensity of the liver and in background air anterior and lateral to the patient. A qualitative analysis of the subjective quality of the T1-weighted images was also done, and the adverse reactions were registered. The groups were homogeneous regarding age, gender, and weight distribution. No significant differences in the signal intensity of the liver and in the incoherent noise measurements were found between the two groups. Gastrointestinal noise showed significant differences between groups, with lower values for the butylscopolamine group compared with the control group. There was also a statistically significant difference in the image quality between groups, and optimal studies were only found in the butylscopolamine group, where most patients had a good-quality evaluation. Regarding adverse events, there were non-significant differences between groups. In conclusion, administration of an antiperistaltic agent to reduce the movements of the gastrointestinal tract diminishes the motion artifacts generated on MR imaging of the abdomen, even at high field strength and with fast imaging sequences. Images of the upper abdomen obtained after pharmacologic suppression of the gastrointestinal movement are of significantly superior quality. (orig.)

  10. Effect of subcutaneous butylscopolamine administration in the reduction of peristaltic artifacts in 1.5-T MR fast abdominal examinations

    Energy Technology Data Exchange (ETDEWEB)

    Dosda, Rosa; Marti-Bonmati, Luis; Molla, Enrique; Arana, Estanislao [Department of Radiology, Clinica Quiron, Avda. Blasco Ibanez, 14, 46017 Valencia (Spain); Ronchera-Oms, Crisanto L. [Pharmacy University College, Fundacion Universitaria San Pablo CEU, Moncada, 46017 Valencia (Spain)

    2003-02-01

    In abdominal MR imaging, ghost artifacts from noncyclic bowel movements can reduce the quality of the images. Although pharmacologic suppression of motion is effective, no study has being conducted to analyze the influence of drug motion suppression on fast breath-hold 1.5-T examinations of the upper abdomen. A prospective, randomized, double-blind trial was conducted in 50 patients. Patients were randomly distributed into two groups: The control group received only an oral solution, whereas the other group received the oral solution plus a subcutaneous injection of 20 mg of butylscopolamine 10 min before the MR examination. Breath-hold T1-weighted gradient-recalled-echo (GRE) MR images were obtained in a 1.5-T superconductive unit. Quantitative image analysis was performed with region-of-interest (ROI) measurements of the signal intensity of the liver and in background air anterior and lateral to the patient. A qualitative analysis of the subjective quality of the T1-weighted images was also done, and the adverse reactions were registered. The groups were homogeneous regarding age, gender, and weight distribution. No significant differences in the signal intensity of the liver and in the incoherent noise measurements were found between the two groups. Gastrointestinal noise showed significant differences between groups, with lower values for the butylscopolamine group compared with the control group. There was also a statistically significant difference in the image quality between groups, and optimal studies were only found in the butylscopolamine group, where most patients had a good-quality evaluation. Regarding adverse events, there were non-significant differences between groups. In conclusion, administration of an antiperistaltic agent to reduce the movements of the gastrointestinal tract diminishes the motion artifacts generated on MR imaging of the abdomen, even at high field strength and with fast imaging sequences. Images of the upper abdomen obtained after pharmacologic suppression of the gastrointestinal movement are of significantly superior quality. (orig.)

  11. Numerical analysis for peristaltic transport of Carreau-Yasuda fluid with variable thermal conductivity and convective conditions

    Institute of Scientific and Technical Information of China (English)

    F M Abbasi; T Hayat; B Ahmad

    2015-01-01

    Peristalsis of Carreau-Yasuda fluid is investigated. Analysis is carried out in the presence of velocity slip and convective boundary conditions. Thermal conductivity of the fluid is taken to be temperature dependent. Lubrication analysis is used in the formulation of the problem. Resulting nonlinear system of equations is solved numerically. Impact of embedded parameters on the quantities of interest is examined through graphs and tables. Comparison of the behavior of the Carreau-Yasuda, Carreau and Newtonian fluid models is presented. Results show that the heat transfer rate at the wall for the Carreau fluid model is large when compared with the Newtonian or the Carreau-Yasuda fluid model. Also the heat transfer rate at the wall decreases with increase in the velocity slip and variable thermal conductivity parameters. Further, an increase in the Biot number reduces the fluid temperature by a considerable amount.

  12. Micro pumping methods based on AC electrokinetics and Electrorheologically actuated PDMS valves

    Science.gov (United States)

    Soni, Gaurav; Squires, Todd; Meinhart, Carl

    2006-11-01

    We have developed 2 different micropumping methods for transporting ionic fluids through microchannels. The first method is based on Induced Charge Electroosmosis (ICEO) and AC flow field-effect. We used an AC electric field to produce a symmetric ICEO flow on a planar electrode, called `gate'. In order to break the symmetry of ICEO, we applied an additional AC voltage to the gate electrode. Such modulation of the gate potential is called field effect and produces a unidirectional pumping over the gate surface. We used micro PIV to measure pumping velocities for a range of ionic concentration, AC frequency and gate voltage. We have also conducted numerical simulations to understand the deteriorating effect of lateral conduction of surface charge on the pumping velocities. The second method is based on vibration of a flexible PDMS diaphragm actuated by an electrorheological (ER) fluid. ER fluid is a colloidal suspension exhibiting a reversible liquid-to-solid transition under an electric field. This liquid-to-solid transition can yield very high shear stress and can be used to open and close a PDMS valve. Three such valves were fabricated and actuated in a peristaltic fashion in order to achieve positive displacement pumping of fluids.

  13. Towards a Multifunctional Electrochemical Sensing and Niosome Generation Lab-on-Chip Platform Based on a Plug-and-Play Concept.

    Science.gov (United States)

    Kara, Adnane; Rouillard, Camille; Mathault, Jessy; Boisvert, Martin; Tessier, Frédéric; Landari, Hamza; Melki, Imene; Laprise-Pelletier, Myriam; Boisselier, Elodie; Fortin, Marc-André; Boilard, Eric; Greener, Jesse; Miled, Amine

    2016-01-01

    In this paper, we present a new modular lab on a chip design for multimodal neurotransmitter (NT) sensing and niosome generation based on a plug-and-play concept. This architecture is a first step toward an automated platform for an automated modulation of neurotransmitter concentration to understand and/or treat neurodegenerative diseases. A modular approach has been adopted in order to handle measurement or drug delivery or both measurement and drug delivery simultaneously. The system is composed of three fully independent modules: three-channel peristaltic micropumping system, a three-channel potentiostat and a multi-unit microfluidic system composed of pseudo-Y and cross-shape channels containing a miniature electrode array. The system was wirelessly controlled by a computer interface. The system is compact, with all the microfluidic and sensing components packaged in a 5 cm × 4 cm × 4 cm box. Applied to serotonin, a linear calibration curve down to 0.125 mM, with a limit of detection of 31 μ M was collected at unfunctionalized electrodes. Added sensitivity and selectivity was achieved by incorporating functionalized electrodes for dopamine sensing. Electrode functionalization was achieved with gold nanoparticles and using DNA and o-phenylene diamine polymer. The as-configured platform is demonstrated as a central component toward an "intelligent" drug delivery system based on a feedback loop to monitor drug delivery. PMID:27240377

  14. Towards a Multifunctional Electrochemical Sensing and Niosome Generation Lab-on-Chip Platform Based on a Plug-and-Play Concept

    Science.gov (United States)

    Kara, Adnane; Rouillard, Camille; Mathault, Jessy; Boisvert, Martin; Tessier, Frédéric; Landari, Hamza; Melki, Imene; Laprise-Pelletier, Myriam; Boisselier, Elodie; Fortin, Marc-André; Boilard, Eric; Greener, Jesse; Miled, Amine

    2016-01-01

    In this paper, we present a new modular lab on a chip design for multimodal neurotransmitter (NT) sensing and niosome generation based on a plug-and-play concept. This architecture is a first step toward an automated platform for an automated modulation of neurotransmitter concentration to understand and/or treat neurodegenerative diseases. A modular approach has been adopted in order to handle measurement or drug delivery or both measurement and drug delivery simultaneously. The system is composed of three fully independent modules: three-channel peristaltic micropumping system, a three-channel potentiostat and a multi-unit microfluidic system composed of pseudo-Y and cross-shape channels containing a miniature electrode array. The system was wirelessly controlled by a computer interface. The system is compact, with all the microfluidic and sensing components packaged in a 5 cm × 4 cm × 4 cm box. Applied to serotonin, a linear calibration curve down to 0.125 mM, with a limit of detection of 31 μM was collected at unfunctionalized electrodes. Added sensitivity and selectivity was achieved by incorporating functionalized electrodes for dopamine sensing. Electrode functionalization was achieved with gold nanoparticles and using DNA and o-phenylene diamine polymer. The as-configured platform is demonstrated as a central component toward an “intelligent” drug delivery system based on a feedback loop to monitor drug delivery. PMID:27240377

  15. Towards a Multifunctional Electrochemical Sensing and Niosome Generation Lab-on-Chip Platform Based on a Plug-and-Play Concept

    Directory of Open Access Journals (Sweden)

    Adnane Kara

    2016-05-01

    Full Text Available In this paper, we present a new modular lab on a chip design for multimodal neurotransmitter (NT sensing and niosome generation based on a plug-and-play concept. This architecture is a first step toward an automated platform for an automated modulation of neurotransmitter concentration to understand and/or treat neurodegenerative diseases. A modular approach has been adopted in order to handle measurement or drug delivery or both measurement and drug delivery simultaneously. The system is composed of three fully independent modules: three-channel peristaltic micropumping system, a three-channel potentiostat and a multi-unit microfluidic system composed of pseudo-Y and cross-shape channels containing a miniature electrode array. The system was wirelessly controlled by a computer interface. The system is compact, with all the microfluidic and sensing components packaged in a 5 cm × 4 cm × 4 cm box. Applied to serotonin, a linear calibration curve down to 0.125 mM, with a limit of detection of 31 μ M was collected at unfunctionalized electrodes. Added sensitivity and selectivity was achieved by incorporating functionalized electrodes for dopamine sensing. Electrode functionalization was achieved with gold nanoparticles and using DNA and o-phenylene diamine polymer. The as-configured platform is demonstrated as a central component toward an “intelligent” drug delivery system based on a feedback loop to monitor drug delivery.

  16. Modeling and optimal design of multilayer thermal cantilever microactuators

    Institute of Scientific and Technical Information of China (English)

    FU JianYu; CHEN DaPeng; YE TianChun; JIAO BinBin; OU Yi

    2009-01-01

    A model of curvature and tip deflection of multilayer thermal cantilever actuators is derived. The sim-plified expression received from the model avoids inverting complex matrices enhances understanding and makes it easier to optimize the structure parameters. Experiment is performed, the modeled andexperimental results demonstrate the validity of the model, and it also indicates that ~oung's module makes great contribution to the deflection; therefore, thin layers cannot be ignored arbitrarily.

  17. 聚合物PMMA材料的无阀微泵研制%Valve-less Micropump Development of the Polymer PMMA Material

    Institute of Scientific and Technical Information of China (English)

    蒋希赟

    2015-01-01

    The valve-less micro pump is often used to directly control micro pump flow, and it avoids the micro pump failure caused by the instability of the valve. This paper described the method of making a microfluidic devices micro pump with polymer PMMA material, put forward some methods of microfluidic manufacturing process and chose the suitable PMMA micro pump manufacturing method, then conducted the valve-less micro pump production and testing, and made flow rate and back pressure test of the micro pump produced with PMMA material, finally combined the developed valve-less micro pump and the integrated free-flow electrophoresis chip to test the its function effect.%无阀微泵经常被使用是为了直接控制微泵的流量,它避免了阀片的不稳定性引起的微泵失效。文章叙述了以聚合物PMMA为材料来制作微流体器件微泵,给出微流体制作工艺的几种方法并从中选出适合于PMMA微泵制作方法,然后进行无阀微泵制作与测试,并对用PMMA材料制作的微泵进行了流量和背压的测试,最后把所研制的无阀微泵与集成化自由流电泳芯片结合测试其功能效果。

  18. Optimal Design and Operation for a No-Moving-Parts-Valve (NMPV) Micro-Pump with a Diffuser Width of 500 μm

    OpenAIRE

    Jia-Ming Sun; Tzong-Shyng Leu; Chin-Tsan Wang

    2009-01-01

    A no-moving-parts-valve (NMPV) with a diffuser width of D = 500 microns was investigated in this study by numerical simulations at Reynolds numbers, ReD, ranging from 20 to 75, and expansion valve angles ranging from 30° < θ1 < 57° and 110° < θ2 < 120°. The D p,i value, 1.02 < D p,i < 1.14, is larger within the proposed range of the expansion valve angles. A flow channel structure with a depth of 500 micron is manufactured using yellow light lithography in this study. From p...

  19. Numerical Simulation of a Colloidal Micropump by Dissipative Particle Dynamics%胶体微泵的耗散粒子动力学模拟

    Institute of Scientific and Technical Information of China (English)

    张光明; 陈硕

    2014-01-01

    应用耗散粒子动力学方法研究了胶体微泵.每个胶体小球按照既定的运动规律相继运动,从而可驱动流体.首先利用耗散粒子动力学方法计算了泊肃叶流动,验证了模拟的正确性.然后模拟了由六个胶体小球组成的周期性胶体微泵的工作过程.胶体颗粒与周围流体粒子之间采用了弹性碰撞模型;模拟中选择了合适的参数,从而可提高流体的粘度并保证DPD流体的不可压缩性.模拟结果与他人的实验数据进行了对比,两者很好吻合.模拟结果显示,胶体微泵的无量纲流量的绝对值随着小球运动ω的变小而增大;而随着ω的减小,无量纲流量的振幅也相应变大.

  20. Valve-less Micropump Development of the Polymer PMMA Material%聚合物PMMA材料的无阀微泵研制

    Institute of Scientific and Technical Information of China (English)

    蒋希赟

    2015-01-01

    The valve-less micro pump is often used to directly control micro pump flow, and it avoids the micro pump failure caused by the instability of the valve. This paper described the method of making a microfluidic devices micro pump with polymer PMMA material, put forward some methods of microfluidic manufacturing process and chose the suitable PMMA micro pump manufacturing method, then conducted the valve-less micro pump production and testing, and made flow rate and back pressure test of the micro pump produced with PMMA material, finally combined the developed valve-less micro pump and the integrated free-flow electrophoresis chip to test the its function effect.%无阀微泵经常被使用是为了直接控制微泵的流量,它避免了阀片的不稳定性引起的微泵失效。文章叙述了以聚合物PMMA为材料来制作微流体器件微泵,给出微流体制作工艺的几种方法并从中选出适合于PMMA微泵制作方法,然后进行无阀微泵制作与测试,并对用PMMA材料制作的微泵进行了流量和背压的测试,最后把所研制的无阀微泵与集成化自由流电泳芯片结合测试其功能效果。

  1. Peristaltic flow of a fluid in a porous channel: A study having relevance to flow of bile within ducts in a pathological state

    CERN Document Server

    Maiti, S; 10.1016/j.ijengsci.2011.05.006

    2011-01-01

    The paper deals with a theoretical study of the transport of a fluid in a channel, which takes place by the phenomenon of peristalsis. A mathematical analysis of the said problem has been presented. The analysis involves the application of a suitable perturbation technique. The velocity profile and the critical pressure for the occurrence of reflux are investigated with particular emphasis by using appropriate numerical methods. The effects of various parameters, such as Reynolds number, pressure gradient, porosity parameter, Darcy number, slip parameter, amplitude ratio and wave number on velocity and critical pressure for reflux are investigated in detail. The computed results are compared with a previous analytical work and an experimental investigation reported earlier in existing scientific literatures. The results of the present study are in conformity to both of them. The study has got some relevance to the physiological flow of bile in the common bile duct in a pathological state. It reveals that in t...

  2. Electronic micropipettor: A versatile fluid propulsion and injection device for micro-flow analysis

    International Nuclear Information System (INIS)

    The shortage of ready to use small sized liquid propulsion and switching devices for microfluidic cells (μ-cell) is a bottleneck in the dissemination of micro-flow analysis (μ-FA), now that microfluidic electrochemical cells can be designed and assembled in any laboratory by thermal transfer of laser printed masks and CD-Rs. Microprocessor-controlled electronic pipettors, commercially available with minimum capacity of 10 μL, represent a compromise solution between oversized peristaltic pumps and tiny 'on a chip' micropumps and valves. The versatility of the electronic pipette coupled with the μ-cell (13-μm deep longitudinal channel) was demonstrated in three operation modes: SIA like, FIA like and direct injection analysis (DIA). Injections of 100 nL K4Fe(China)6 (0.1 mol L-1 KCl) define a linear analytical curve (r = 0.999) in the range of 5 x 10-7 to 1.0 x 10-3 mol L-1 for flow amperometry at a gold electrode potentiostated at 0.4 V versus Ag/AgCl. Methods for the amperometric μ-flow determination of promethazine (FIA like), dipyrone (SIA like) and chlorpromazine (DIA) in pharmaceutical formulations were developed and applied to real samples. Excellent linearity of analytical curves and high repeatability (R.S.D. < 3.0%) at the low picomole range was obtained and all results for real samples were in agreement with reference methods. The results reflect the stability and the reliability of the setups envisioned for the electronic pipette coupled with amperometric μ-cell and the validity of the μ-FA methods

  3. An integrated microfluidic sensor for real-time detection of RNA in seawater using preserved reagents

    Science.gov (United States)

    Tsaloglou, M.-N.; Loukas, C. M.; Ruano-López, J. M.; Morgan, H.; Mowlem, M. C.

    2012-04-01

    Quantitation of RNA sequences coding either for key metabolic proteins or highly conserved ribosomal subunits can provide insight on cell abundance, speciation and viability. Nucleic sequence-based amplification (NASBA) is an isothermal alternative to traditional nucleic acid amplification methods, such as quantitative PCR. We present here an integrated microfluidic sensor for cell concentration and lysis, RNA extraction/purification and quantitative RNA detection for environmental applications. The portable system uses pre-loaded reagents, stored as a gel on a disposable microfluidic cartridge, which is manufactured using low-cost injection moulding. The NASBA reaction is monitored real-time using a bespoke control unit which includes: an external fluorescence detector, three peristaltic micro-pumps, two heaters and temperature sensors, a battery, seven pin actuated micro-motors (or valve actuators), and an automatic cartridge insertion mechanism. The system has USB connectivity and none of the expensive components require replacing between reactions. Long-term storage of reagents is critically important for any diagnostic tool that will be used in the field, whether for medical or environmental analysis and has not been previously demonstrated for NASBA reagents on-chip. We have shown effective amplification, for as little as 500 cells of the toxic microalga Karenia brevis using reagents which had been preserved as a gel for 45 days. This is the first reported real-time isothermal RNA amplification using with on-chip preservation. Annealing of primers, amplification at 41 °C and real-time fluorescence detection using, also for the first time, an internal control and sequence-specific molecular beacons was all performed on our microfluidic sensor. Our results show excellent promise as a future quantitative tool of in situ phytoplankton analysis and other environmental applications, where long-term reagent storage and low power consumption is essential.

  4. A batch-fabricated laser-micromachined PDMS actuator with stamped carbon grease electrodes

    International Nuclear Information System (INIS)

    In this note, we report on the development of a batch-fabricated laser-micromachined elastomeric cantilever actuator composed of a polydimethylsiloxane (PDMS) bilayer (active/inactive) and soft-lithographically patterned conductive carbon grease electrodes. The described unimorph structure has a low actuation voltage and large out-of-plane displacement. For a 4 mm long, 1 mm wide, and 80 µm thick actuator, an out-of-plane displacement of 1.2 mm and a maximum force of 25 µN were measured using 450 V actuation voltage. (technical note)

  5. Lorentz force actuation of a heated atomic force microscope cantilever

    International Nuclear Information System (INIS)

    We report Lorentz force-induced actuation of a silicon microcantilever having an integrated resistive heater. Oscillating current through the cantilever interacts with the magnetic field around a NdFeB permanent magnet and induces a Lorentz force that deflects the cantilever. The same current induces cantilever heating. With AC currents as low as 0.2 mA, the cantilever can be oscillated as much as 80 nm at resonance with a DC temperature rise of less than 5 °C. By comparison, the AC temperature variation leads to a thermomechanical oscillation that is about 1000 times smaller than the Lorentz deflection at the cantilever resonance. The cantilever position in the nonuniform magnetic field affects the Lorentz force-induced deflection, with the magnetic field parallel to the cantilever having the largest effect on cantilever actuation. We demonstrate how the cantilever actuation can be used for imaging, and for measuring the local material softening temperature by sensing the contact resonance shift. (paper)

  6. An Atomic Force Microscope with Dual Actuation Capability for Biomolecular Experiments

    Science.gov (United States)

    Sevim, Semih; Shamsudhin, Naveen; Ozer, Sevil; Feng, Luying; Fakhraee, Arielle; Ergeneman, Olgaç; Pané, Salvador; Nelson, Bradley J.; Torun, Hamdi

    2016-06-01

    We report a modular atomic force microscope (AFM) design for biomolecular experiments. The AFM head uses readily available components and incorporates deflection-based optics and a piezotube-based cantilever actuator. Jetted-polymers have been used in the mechanical assembly, which allows rapid manufacturing. In addition, a FeCo-tipped electromagnet provides high-force cantilever actuation with vertical magnetic fields up to 0.55 T. Magnetic field calibration has been performed with a micro-hall sensor, which corresponds well with results from finite element magnetostatics simulations. An integrated force resolution of 1.82 and 2.98 pN, in air and in DI water, respectively was achieved in 1 kHz bandwidth with commercially available cantilevers made of Silicon Nitride. The controller and user interface are implemented on modular hardware to ensure scalability. The AFM can be operated in different modes, such as molecular pulling or force-clamp, by actuating the cantilever with the available actuators. The electromagnetic and piezoelectric actuation capabilities have been demonstrated in unbinding experiments of the biotin-streptavidin complex.

  7. Analysis and Test of Piezoelectric Micropump for Drug Delivery%微型药品输送压电泵的性能分析与试验研究

    Institute of Scientific and Technical Information of China (English)

    阚君武; 宣明; 杨志刚; 吴一辉; 吴博达; 程光明

    2005-01-01

    微系统(泵)给药易于控制药品释放速度,进而提高药物疗效.研制了一种微型薄膜阀压电驱动微型泵,适用于内置式或便携式药品输送系统.分析压电振子及阀片动态特性的影响因素,给出了薄膜阀片谐振频率的计算方法.分析结果表明,阀和压电振子的耦合作用决定了压电泵的输出特性,对于确定的压电振子,通过阀片设计可提高压电泵的最佳工作频率和输出能力.制作了阀片尺寸不同的两个微型压电泵,进行了对比试验.小阀片微型压电泵输出的能力及最佳工作频率较高,且有两个最佳工作频率段(800 Hz和3 000 Hz),输出流量和压力分别为3.5 ml/min和27 KPa;大阀片压电泵的输出能力和最佳工作频率相对较低,只有一个最佳工作频率点(200 Hz左右),输出流量和压力分别为3.0 ml/min和9.5 KPa.这说明通过阀片的设计可提高药用微型压电泵的最佳工作频率及输出能力、减小输出脉动,以往认为有阀压电泵只能在低频状态工作的观点是错误的.

  8. 不对称柔性壁管道内幂律流体蠕动传输的精确解%Exact Solution for Peristaltic Transport of Power-Law Fluid in an Asymmetric Channel With Compliant Walls

    Institute of Scientific and Technical Information of China (English)

    T·哈亚特; M·贾佛德1; 黄绍红

    2010-01-01

    在不对称管道内,研究了壁面柔曲性对非Newton流体蠕动流的影响.流变学性质由幂律流体本构方程表征.在数学表达中,采用了长波和低Reynolds数近似.得到了流函数和速度的精确解.给出了流线图及其俘获现象.对所讨论的流动,陈列了关键参数的显著特征,并最后给出了主要结论.

  9. Getting Started with PEAs-Based Flapping-Wing Mechanisms for Micro Aerial Systems

    Directory of Open Access Journals (Sweden)

    José Carlos Durán Hernández

    2016-05-01

    Full Text Available This paper introduces recent advances on flapping-wing Micro and Nano Aerial Vehicles (MAVs and NAVs based on Piezoelectric Actuators (PEA. Therefore, this work provides essential information to address the development of such bio-inspired aerial robots. PEA are commonly used in micro-robotics and precise positioning applications (e.g., micro-positioning and micro-manipulation, whereas within the Unmanned Aerial Vehicles (UAVs domain, motors are the classical actuators used for rotary or fixed-wing configurations. Therefore, we consider it pertinent to provide essential information regarding the modeling and control of piezoelectric cantilever actuators to accelerate early design and development stages of aerial microrobots based on flapping-wing systems. In addition, the equations describing the aerodynamic behavior of a flapping-wing configuration are presented.

  10. A flexoelectric microelectromechanical system on silicon.

    Science.gov (United States)

    Bhaskar, Umesh Kumar; Banerjee, Nirupam; Abdollahi, Amir; Wang, Zhe; Schlom, Darrell G; Rijnders, Guus; Catalan, Gustau

    2016-03-01

    Flexoelectricity allows a dielectric material to polarize in response to a mechanical bending moment and, conversely, to bend in response to an electric field. Compared with piezoelectricity, flexoelectricity is a weak effect of little practical significance in bulk materials. However, the roles can be reversed at the nanoscale. Here, we demonstrate that flexoelectricity is a viable route to lead-free microelectromechanical and nanoelectromechanical systems. Specifically, we have fabricated a silicon-compatible thin-film cantilever actuator with a single flexoelectrically active layer of strontium titanate with a figure of merit (curvature divided by electric field) of 3.33 MV(-1), comparable to that of state-of-the-art piezoelectric bimorph cantilevers. PMID:26571008

  11. Mechanical behavior simulation of MEMS-based cantilever beam using COMSOL multiphysics

    Energy Technology Data Exchange (ETDEWEB)

    Acheli, A., E-mail: aacheli@cdta.dz; Serhane, R. [Centre de Développement des Technologies Avancées (CDTA). BP n°17 Baba Hassen, Alger (Algeria)

    2015-03-30

    This paper presents the studies of mechanical behavior of MEMS cantilever beam made of poly-silicon material, using the coupling of three application modes (plane strain, electrostatics and the moving mesh) of COMSOL Multi-physics software. The cantilevers playing a key role in Micro Electro-Mechanical Systems (MEMS) devices (switches, resonators, etc) working under potential shock. This is why they require actuation under predetermined conditions, such as electrostatic force or inertial force. In this paper, we present mechanical behavior of a cantilever actuated by an electrostatic force. In addition to the simplification of calculations, the weight of the cantilever was not taken into account. Different parameters like beam displacement, electrostatics force and stress over the beam have been calculated by finite element method after having defining the geometry, the material of the cantilever model (fixed at one of ends but is free to move otherwise) and his operational space.

  12. Novel Versatile Intelligent Drug Delivery Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR project will demonstrate and develop a novel micro-pump capable of controlled and selective chemical transport. Phase I will create, characterize, and...

  13. Continuous micro liquid delivery by evaporation on a gradient-capillary microstructure surface

    International Nuclear Information System (INIS)

    An evaporation-based micropump is proposed and fabricated for delivering liquid with constant flow rates of ∼100 nl s−1 continuously. The liquid is pumped by the surface transpiration in a micro evaporator, which consists of a gradient-capillary surface by microfabricating micropost arrays. The micropost arrays are patterned such that the gaps between microposts reduce gradually away from the center microwell to the surface edge, by which a capillary force is formed to pull the liquid spreading on the evaporator surface. A simple analytical model is proposed to obtain the primary characteristics of the micropump, by which the influences of the contact angle of fluid on the flow rate and also the corresponding parameters during the operation of micropump are analyzed. The most striking feature of the micropump is that it can be precisely and simply controlled only by varying the surface wall temperature. The results indicate that a very linear relationship between the flow rate and solid wall temperature can be achieved by the present design. Quite consistent variation trend of the flow rate with wall temperature can be obtained between the experimental tests and theoretical analysis. The present micropump concept may be potentially used in delivering a precisely controlled, continuous flow rate for many new applications in the fields of biotechnology, environmental testing and instrumentation for analytical chemistry

  14. Miniature ion-sorption vacuum pump with CNT field-emission electron source

    International Nuclear Information System (INIS)

    Generation and maintenance of the high vacuum in the MEMS-type (micro-electro-mechanical system) microsystems and vacuum nanoelectronics devices remain a major problem today. The phenomena of gas desorption from the surface of a microcavity and outgassing of materials limit the vacuum to the level of about 10−1 Pa. In this paper, a new MEMS-type micropump for generating a high vacuum in a microcavity is presented. The main component of the ion-sorption micropump is a carbon nanotube (CNT) field-emission electron source. Test structures of the electron source with electrophoretically deposited CNT have been fabricated and measured. A satisfactory value of the emission current and a low turn-on voltage have been obtained. The elaborated electron source has been applied to the micropump structure; it has enabled us to achieve a vacuum level below 10−3 Pa. (paper)

  15. System-in Package of Integrated Humidity Sensor Using CMOS-MEMS Technology.

    Science.gov (United States)

    Lee, Sung Pil

    2015-10-01

    Temperature/humidity microchips with micropump were fabricated using a CMOS-MEMS process and combined with ZigBee modules to implement a sensor system in package (SIP) for a ubiquitous sensor network (USN) and/or a wireless communication system. The current of a diode temperature sensor to temperature and a normalized current of FET humidity sensor to relative humidity showed linear characteristics, respectively, and the use of the micropump has enabled a faster response. A wireless reception module using the same protocol as that in transmission systems processed the received data within 10 m and showed temperature and humidity values in the display. PMID:26726359

  16. Three-dimensional study of a one-way, flexible magnetorheological elastomer-based micro fluid transport system

    Science.gov (United States)

    Behrooz, Majid; Gordaninejad, Faramarz

    2016-09-01

    This paper presents a three-dimensional study of a controllable flexible magnetically-activated micropump. The tubular micropump employs magnetically induced deformation of magnetorheological elastomer and one-way flexible conical valves for fluid transport. Three-dimensional magneto–fluid–solid interaction analysis is employed to investigate the performance of the system. The effects of key material, geometric, and magnetic parameters on the effectiveness of the system are examined. It is demonstrated that the proposed system can propel the fluid unidirectionally, and the volume of the transported fluid is significantly affected by some of the design parameters.

  17. A highly aromatic and sulfonated ionomer for high elastic modulus ionic polymer membrane micro-actuators

    International Nuclear Information System (INIS)

    A high modulus, sulfonated ionomer synthesized from 4,6-bis(4-hydroxyphenyl)-N,N-diphenyl-1,3,5-triazin-2-amine and 4,4′-biphenol with bis(4-fluorophenyl)sulfone (DPA-PS:BP) is investigated for ionic polymer actuators. The uniqueness of DPA-PS:BP is that it can have a high ionic liquid (IL) uptake and consequently generates a high intrinsic strain response, which is >1.1% under 1.6 V while maintaining a high elastic modulus (i.e. 600 MPa for 65 vol% IL uptake). Moreover, such a high modulus of the active ionomer, originating from the highly aromatic backbone and side-chain-free structure, allows for the fabrication of free-standing thin film micro-actuators (down to 5 µm thickness) via the solution cast method and focused-ion-beam milling, which exhibits a much higher bending actuation, i.e. 43 µm tip displacement and 180 kPa blocking stress for a 200 µm long and 5 µm thick cantilever actuator, compared with the ionic actuators based on traditional ionomers such as Nafion, which has a much lower elastic modulus (50 MPa) and actuation strain. (paper)

  18. Analytical solutions to flexural vibration of slender piezoelectric multilayer cantilevers

    International Nuclear Information System (INIS)

    The modeling of vibration of piezoelectric cantilevers has often been based on passive cantilevers of a homogeneous material. Although piezoelectric cantilevers and passive cantilevers share certain characteristics, this method has caused confusion in incorporating the piezoelectric moment into the differential equation of motion. The extended Hamilton’s principle is a fundamental approach to modeling flexural vibration of multilayer piezoelectric cantilevers. Previous works demonstrated derivation of the differential equation of motion using this approach; however, proper analytical solutions were not reported. This was partly due to the fact that the differential equation derived by the extended Hamilton’s principle is a boundary-value problem with nonhomogeneous boundary conditions which cannot be solved by modal analysis. In the present study, an analytical solution to the boundary-value problem was obtained by transforming it into a new problem with homogeneous boundary conditions. After the transformation, modal analysis was used to solve the new boundary-value problem. The analytical solutions for unimorphs and bimorphs were verified with three-dimensional finite element analysis (FEA). Deflection profiles and frequency response functions under voltage, uniform pressure and tip force were compared. Discrepancies between the analytical results and FEA results were within 3.5%. Following model validation, parametric studies were conducted to investigate the effects of thickness of electrodes and piezoelectric layers, and the piezoelectric coupling coefficient d 31 on the performance of piezoelectric cantilever actuators. (paper)

  19. Biocompatible circuit-breaker chip for thermal management of biomedical microsystems

    International Nuclear Information System (INIS)

    This paper presents a thermoresponsive micro circuit breaker for biomedical applications specifically targeted at electronic intelligent implants. The circuit breaker is micromachined to have a shape-memory-alloy cantilever actuator as a normally closed temperature-sensitive switch to protect the device of interest from overheating, a critical safety feature for smart implants including those that are electrothermally driven with wireless micro heaters. The device is fabricated in a size of 1.5  ×  2.0  ×  0.46 mm3 using biocompatible materials and a chip-based titanium package, exhibiting a nominal cold-state resistance of 14 Ω. The breaker rapidly enters the full open condition when the chip temperature exceeds 63 °C, temporarily breaking the circuit of interest to lower its temperature until chip temperature drops to 51 °C, at which the breaker closes the circuit to allow current to flow through it again, physically limiting the maximum temperature of the circuit. This functionality is tested in combination with a wireless resonant heater powered by radio-frequency electromagnetic radiation, demonstrating self-regulation of heater temperature. The developed circuit-breaker chip operates in a fully passive manner that removes the need for active sensor and circuitry to achieve temperature regulation in a target device, contributing to the miniaturization of biomedical microsystems including electronic smart implants where thermal management is essential. (paper)

  20. Nonlinear analysis of RAINBOW actuator characteristics

    International Nuclear Information System (INIS)

    This paper discusses an investigation into deformations of rectangular RAINBOW actuators, which are classified as a type of laminated actuator. The actuators consist of a piezoelectric active layer and a reduced passive layer formed in an elevated temperature reduction process. An energy-based Rayleigh–Ritz model is used to approximate the thermally induced deformations with 23-term polynomials. Due to large out-of-plane displacements of the RAINBOW actuators after cooling down to room temperature, inclusion of geometric nonlinearities in the kinematic relations is taken into consideration. Actuation characteristics of these actuators caused by a quasi-static electric field applied to the piezoelectric layer are also modeled with the Rayleigh–Ritz approach. Material nonlinearities in the piezoelectric layer are included in the constitutive equation to capture the effects of a strong electric field. Piezoelectrically induced tip deflections of a series of RAINBOW cantilever actuators are calculated and compared with experiment. With the geometrical and material nonlinearities taken into account, numerical simulation reveals the computed tip deflections agree very well with the experimental data. In addition, tip blocking forces representing the load-carrying capability of the RAINBOW actuators are approximately evaluated by equating the magnitude of force-induced displacement to that of the piezoelectrically induced tip deflection. Again, good agreement between numerical results and experiment can be observed in the case of the tip blocking force. This evidently shows that the pertinent nonlinearities have very crucial effects on the responses and performances of the RAINBOW actuators

  1. Multifunctional atomic force microscope cantilevers with Lorentz force actuation and self-heating capability

    International Nuclear Information System (INIS)

    This paper reports the development of microcantilevers capable of self-heating and Lorentz-force actuation, and demonstrates applications to thermal topography imaging. Electrical current passing through a U-shaped cantilever in the presence of a magnetic field induces a Lorentz force on the cantilever free end, resulting in cantilever actuation. This same current flowing through a resistive heater induces a controllable temperature increase. We present cantilevers designed for large actuation forces for a given cantilever temperature increase. We analyze the designs of two new cantilevers, along with a legacy cantilever design. The cantilevers are designed to have a spring constant of about 1.5 N m−1, a resonant frequency near 100 kHz, and self-heating capability with temperature controllable over the range 25–600 °C. Compared to previous reports on self-heating cantilevers, the Lorentz–thermal cantilevers generate up to seven times as much Lorentz force and two times as much oscillation amplitude. When used for thermal topography imaging, the Lorentz–thermal cantilevers can measure topography with a vertical resolution of 0.2 nm. (paper)

  2. Moving-part-free microfluidic systems for lab-on-a-chip

    International Nuclear Information System (INIS)

    Microfluidic systems are part of an emerging technology which deals with minute amounts of liquids (biological samples and reagents) on a small scale. They are fast, compact and can be made into a highly integrated system to deliver sample purification, separation, reaction, immobilization, labelling, as well as detection, thus are promising for applications such as lab-on-a-chip and handheld healthcare devices. Miniaturized micropumps typically consist of a moving-part component, such as a membrane structure, to deliver liquids, and are often unreliable, complicated in structure and difficult to be integrated with other control electronics circuits. The trend of new-generation micropumps is moving-part-free micropumps operated by advanced techniques, such as electrokinetic force, surface tension/energy, acoustic waves. This paper reviews the development and advances of relevant technologies, and introduces electrowetting-on-dielectrics and acoustic wave-based microfluidics. The programmable electrowetting micropump has been realized to dispense and manipulate droplets in 2D with up to 1000 addressable electrodes and electronics built underneath. The acoustic wave-based microfluidics can be used not only for pumping, mixing and droplet generation but also for biosensors, suitable for single-mechanism-based lab-on-a-chip applications

  3. Modeling and Simulation Framework for Flow-Based Microfluidic Biochips

    DEFF Research Database (Denmark)

    Schmidt, Morten Foged; Minhass, Wajid Hassan; Pop, Paul;

    2013-01-01

    several microvalves, more complex units, such as micropumps, switches, mixers, and multiplexers, can be built. Such biochips are becoming increasingly complex, with thousands of components, but are still designed manually using a bottom-up full-custom design approach, which is extremely labor intensive...

  4. Advances In Mesoscale Thermal Management Technologies for Microelectronics

    OpenAIRE

    Garimella, S V

    2005-01-01

    This paper presents recent advances in a number of novel, high-performance cooling techniques for emerging electronics applications Critical enabling thermal management technologies covered include microchannel transport and micropumps, jet impingement, miniatur flat heat pipes, transient phase change energy storage systems, piezoelectric fans, and prediction of interface contact conductance. (c) 2005 Elsevier Ltd. All rights reserved.

  5. Experimental characterization of novel microdiffuser elements

    Science.gov (United States)

    Ehrlich, L.; Punch, J.; Jeffers, N.; Stafford, J.

    2014-07-01

    Micropumps can play a significant role in thermal management applications, as a component of microfluidic cooling systems. For next-generation high density optical communication systems, in particular, heat flux levels are sufficiently high to require a microfluidic circuit for cooling. Valveless piezoelectrically-actuated micropumps are a particularly promising technology to be deployed for this application. These pumps exploit the asymmetric flow behaviour of microdiffusers to achieve net flow. They feature no rotating or contacting parts, which make them intrinsically reliable in comparison to micropumps with active valves. In this paper, two novel microdiffuser elements are reported and characterized. The micropumps were fabricated using a 3D Printer. Each single diffuser had a length of 1800 pm and a depth of 400 pm. An experimental characterization was conducted in which the flow rate and differential pressure were measured as a function of operating frequency. In comparison with standard diffuser, both elements showed an increase in differential pressure in the range of 40 - 280 %, but only one of the elements exhibited an improved flow rate, of about 85 %.

  6. The maximum life expectancy for a micro-fabricated diaphragm

    Science.gov (United States)

    Cǎlimǎnescu, Ioan; Stan, Liviu-Constantin; Popa, Viorica

    2015-02-01

    Micro-fabricated diaphragms can be used to provide pumping action in microvalve and microfluidic applications. The functionality of the microdiaphragm in a wirelessly actuated micropump plays a major role in low-powered device actuation. In developing micropumps and their components, it is becoming an increasing trend to predict the performance before the prototype is fabricated. Because performance prediction allows for an accurate estimation of yield and lifetime, in addition to developing better understanding of the device while taking into account the details of the device structure and second order effects. Hence avoid potential pitfalls in the device operation in a practical environment. The goal of this research is to determine via FEA the life expectancy for a corrugated circular diaphragm made out of an aluminum alloy. The geometry of the diaphragm is given below being generated within SolidWorks 2010, all the calculations were made using Ansys 13TM . The sound design of a micropump is heavily depending on the lifetime expectancy of the working part of the device which is the diaphragm. This will be subjected on cyclic loading and the fatigue will limit the life of this part. Once the diaphragm is breaking, the micropump is no more able to fulfill its scope. Any micropump manufacturer will then be very concerned on the life expectancy from the fatigue point of view of the diaphragms. The diaphragm circular and corrugated and made of Al alloy, showed a very good behavior from the fatigue point of view, the maximum life expectancy being 1.9 years of continuous functioning with 100 cycles per second. This work showed an simple and forward application of FEA analysis methods in order to estimate the fatigue behavior of corrugated circular microdiaphragms.

  7. Development of wearable medical device for Bio-MEMS

    Science.gov (United States)

    Nakanishi, Naoyuki; Yamamoto, Hidetake; Tsuchiya, Kazuyoshi; Uetsuji, Yasutomo; Nakamachi, Eiji

    2006-01-01

    Biomedical Micro Electro Mechanical Systems (Bio-MEMS) have been applied to the development of a variety of health care related products including health Monitoring Systems (HMS) and Drug Delivery Systems (DDS). We focus on research to develop the new type compact medical device used for blood sugar control. The new type compact medical device comprises (1) a micropump system to extract blood using a pressure change occurred by electrolysis, (2) a platinum (Pt) electrode as a blood sugar sensor immobilized Glucose Oxidase (GOx) and attached to the gate electrode of Metal-Oxide-Semiconductor Field Effect Transistor (MOSFET) to detect the amount of glucose in extracted blood, and (3) a micropump system to inject insulin using a pressure change occurred by electrolysis. The device can extract blood in a few microliter through a painless microneedle with the micropump, which used the pressure change occurred by electrolysis. The liquid extraction ability of the micropump system through a microneedle, which is 3.8 mm in length and 100 μm in internal diameter, was measured. The wearable medical device with using the micropump controlled by electrolysis could extract human blood at the speed of 0.15 μl/sec. If the wearable medical device extracts human blood for 6 seconds, it is enough human blood volume to measure a glucose level, compared to the amount of commercial based glucose level monitor. The compact medical device with the air bubble that occurred by electrolysis could inject insulin at the speed of 6.15μl/sec.

  8. Microfluidic pumping, routing and metering by contactless metal-based electro-osmosis.

    Science.gov (United States)

    Fu, Xiaotong; Mavrogiannis, Nicholas; Doria, Steven; Gagnon, Zachary

    2015-09-01

    Over the past decade, many microfluidic platforms for fluid processing have been developed in order to perform on-chip fluidic manipulations. Many of these methods, however, require expensive and bulky external supporting equipment, which are not typically applicable for microsystems requiring portability. We have developed a new type of portable contactless metal electro-osmotic micropump capable of on-chip fluid pumping, routing and metering. The pump operates using two pairs of gallium metal electrodes, which are activated using an external voltage source, and separated from a main flow channel by a thin micron-scale PDMS membrane. The thin contactless membrane allows for field penetration and electro-osmotic (EO) flow within the microchannel, but eliminates electrode damage and sample contamination commonly associated with traditional DC electro-osmotic pumps that utilize electrodes in direct contact with the working fluid. The maximum flow rates and pressures generated by the pump using DI water as a working buffer are 10 nL min(-1) and 30 Pa, respectively. With our current design, the maximum operational conductivity where fluid flow is observed is 0.1 mS cm(-1). Due to the small size and simple fabrication procedure, multiple micropump units can be integrated into a single microfluidic device for automated on-chip routing and sample metering applications. We experimentally demonstrated the ability to quantify micropump electro-osmotic flowrate and pressure as a function of applied voltage, and developed a mathematical model capable of predicting the performance of a contactless micropump for a given external load and internal hydrodynamic microchannel resistance. Finally, we showed that by activating specific pumps within a microchannel network, our micropumps are capable of routing microchannel fluid flow and generating plugs of solute. PMID:26053965

  9. Stimuli-responsive cylindrical hydrogels mimic intestinal peristalsis to propel a solid object.

    Science.gov (United States)

    Nistor, V; Cannell, J; Gregory, J; Yeghiazarian, L

    2016-04-13

    The emerging field of soft robotics relies on soft, stimuli-responsive materials to enable load transport, manipulation, and mobility in complex unconstrained environments. These materials often need to replicate biological functionality such as muscle contractions and flexibility. Here we demonstrate a soft actuator prototype based on thermosensitive PNIPAAM hydrogels that can transport and manipulate objects. A hollow cylindrical hydrogel was selectively heated and cooled with Peltier devices to yield a traveling wave of shrinking and swelling akin to intestinal peristalsis. A 4 mm diameter bead was placed inside the cylinder and propelled 19.5 mm, equal to distance traveled by the peristaltic wave. We derived conditions that enable peristaltic transport as a function of transporter-cargo design parameters. We conclude that hydrogel-based peristaltic manipulators covering 2 orders of magnitude in stiffness (1-10(2) kPa) could transport cargo spanning 4 orders of magnitude in size (μm-m). PMID:26971454

  10. Physiological breakdown of Jeffrey six constant nanofluid flow in an endoscope with nonuniform wall

    Directory of Open Access Journals (Sweden)

    S. Nadeem

    2015-12-01

    Full Text Available This paper analyse the endoscopic effects of peristaltic nanofluid flow of Jeffrey six-constant fluid model in the presence of magnetohydrodynamics flow. The current problem is modeled in the cylindrical coordinate system and exact solutions are managed (where possible under low Reynolds number and long wave length approximation. The influence of emerging parameters on temperature and velocity profile are discussed graphically. The velocity equation is solved analytically by utilizing the homotopy perturbation technique strongly, while the exact solutions are computed from temperature equation. The obtained expressions for velocity , concentration and temperature is sketched during graphs and the collision of assorted parameters is evaluate for transform peristaltic waves. The solution depend on thermophoresis number Nt, local nanoparticles Grashof number Gr, and Brownian motion number Nb. The obtained expressions for the velocity, temperature, and nanoparticles concentration profiles are plotted and the impact of various physical parameters are investigated for different peristaltic waves.

  11. Instrumental modification intended to save time, and volumes of sample and reagent solutions, in the atomic fluorescence spectrometric determination of mercury.

    Science.gov (United States)

    Pérez-Sirvent, Carmen; Martínez-Sánchez, María J; García-Lorenzo, Mariluz; López-García, Ignacio; Hernández-Córdoba, Manuel

    2007-05-01

    Use of small membrane pumps, instead of peristaltic pumps, to introduce sample and reagent solutions into the spectrometer has several advantages in atomic fluorescence spectrometric determination of mercury. This simple modification results in a substantial saving in the time required for the measurements and so 90% of reagent solution volumes and 95% of sample solution volumes are saved, with a consequent decrease in the volume of waste generated. The sampling frequency is almost tripled, with no deterioration in sensitivity, which is similar to that obtained by use of peristaltic pumps. The relative standard deviation for ten consecutive measurements of a 1 microg L-1 mercury solution was approximately 2%. PMID:17351707

  12. Vibration energy harvesting in railway tunnels with a wireless sensor node application

    Energy Technology Data Exchange (ETDEWEB)

    Wischke, Martin

    2012-07-01

    Vibration harvesting is a promising concept to prolong the lifetime of batterypowered stand-alone systems, or even to enable their energy-autonomy. This thesis focuses on ambient vibrations converted by electromechanical transducers into electricity. The final goal is energy scavenging from train-induced vibrations in railway tunnels. This is achieved via the development of a suitable harvester for this environment and the practical demonstration of a vibrationpowered wireless sensor node (WSN). At the beginning of this thesis, extensive vibration measurements were performed in several traffic tunnels. The obtained unique data set formed the basis for the design and test of several harvesters. The railway sleeper was chosen as usable harvester location. A shock-resistant double-side suspended piezoelectric cantilever was developed. Several cantilevers with different eigenfrequencies are combined in an array, creating a robust harvester with a broad bandwidth. A field test of 7 days in the Loetschbergbasis-tunnel verified that, on average the sufficient energy for powering a virtual wireless sensor node was scavenged. For application in a real WSN, the harvester array was scaled up to 10 cantilevers. The power management for the sensor node was developed concurrently. The central component is a power switch that monitors the energy level in the system's storage capacitor and only triggers the wireless interface when sufficient energy is available. Combined with a train detection circuit, the presented energy-autonomous WSN reliably reports every passing vehicle. In addition to the development of an energy-autonomous fully integrated WSN, this work investigates nonlinear properties of PZT ceramics. Consideration of the elastostriction and the electrostriction enables a more precises prediction of the tip displacement of a piezoelectric cantilever actuator. Further, the elastostriction is exploited to modify the resonance frequency of a bimorph cantilever. Basing

  13. Design and characterisation of micro-diaphragm for low power drug delivery applications

    Science.gov (United States)

    Dissanayake, Don W.; Al-Sarawi, Said F.; Lu, Tien-Fu; Abbott, Derek

    2008-03-01

    Micro-fabricated diaphragms can be used to provide pumping action in microvalve and microfluidic applications. In this paper, a design for a micro-diaphragm that features low power and small area is presented. The diaphragm is actuated using a Surface Acoustic Wave (SAW) device that is interrogated from an RF signal to provide secure actuation operation. The micropump is targeted for in vivo nano-scale drug delivery and similar applications. For low power micropump operation, it is important to design the diaphragm with a higher flexibility while maintaining the stability. Analysis is carried out using ANSYS simulation tools with different design methods and materials. Results achieved from analytical and Finite Element Modeling (FEM) methods are compared and discussed to decide on optimal dimensions for the diaphragm.

  14. Capillary electrophoresis microchip coupled with on-line chemiluminescence detection

    International Nuclear Information System (INIS)

    In the present work, chemiluminescence detection was integrated with capillary electrophoresis microchip. The microchip was designed on the principle of flow-injection chemiluminescence system and capillary electrophoresis. It has three main channels, five reservoirs and a detection cell. As model samples, dopamine and catechol were separated and detected using a permanganate chemiluminescent system on the prepared microchip. The samples were electrokinetically injected into the double-T cross section, separated in the separation channel, and then oxidized by chemiluminescent reagent delivered by a home-made micropump to produce light in the detection cell. The electroosmotic flow could be smoothly coupled with the micropump flow. The detection limits for dopamine and catechol were 20.0 and 10.0 μM, respectively. Successful separation and detection of dopamine and catechol demonstrated the distinct advantages of integration of chemiluminescent detection on a microchip for rapid and sensitive analysis

  15. A microspray-based cooling system for high powered LEDs

    International Nuclear Information System (INIS)

    Highlights: • Microspray-based cooling system for the thermal management of LEDs. • The spray exited the nozzle using piezo-electric micropumping. • The effect of cooling in a non-boiling regime was quantitatively studied. - Abstract: We propose a microspray-based cooling system for the thermal management of high-power, light emitting diodes (LEDs). Experiments were performed by applying a single microspray to a single and a four LED system. The spray exited the nozzle using piezo-electric micropumping. The effect of cooling in a non-boiling regime was quantitatively studied within a range of relevant operating parameters. Furthermore, both μPIV flow visualizations, infrared thermal image observation and flow field measurements were first made to investigate the heat transfer mechanisms involved in this complex process

  16. Effect of esophageal emptying and saliva on clearance of acid from the esophagus

    International Nuclear Information System (INIS)

    The clearance of acid from the esophagus and esophageal emptying in normal subjects was studied. A 15-ml bolus of 0.1 N hydrochloric acid (pH 1.2) radiolabeled with [/sup 99m/Tc]sulfur colloid was injected into the esophagus, and the subject swallowed every 30 seconds. Concurrent manometry and radionuclide imaging showed nearly complete emptying of acid from the esophagus by an immediate secondary peristaltic sequence, although esophageal pH did not rise until the first swallow 30 seconds later. Esophageal pH then returned to normal by a series of step increases, each associated with a swallow-induced peristaltic sequence. Saliva stimulation by an oral lozenge shortened the time required for acid clearance, whereas aspiration of saliva from the mouth abolished acid clearance. Saliva stimulation or aspiration did not affect the virtually complete emptying of acid volume by the initial peristaltic sequence. It was concluded that esophageal acid clearance normally occurs as a two-step process: (1) Virtually all acid volume is emptied from the esophagus by one or two peristaltic sequences, leaving a minimal residual amount that sustains a low pH, and (2) residual acid is neutralized by swallowed saliva

  17. Gastric pH distribution and mixing of soft and rigid food particles in the stomach using a dual-marker technique

    Science.gov (United States)

    Mixing of a particle-laden material during peristaltic flow in the stomach has not been quantified in vivo. Gastric mixing plays a key role in the overall gastric digestion process; it determines the availability of acid and enzymes to individual solid food particles and controls the length of time ...

  18. Dead Waters: Large amplitude interfacial waves generated by a boat in a stratified fluid

    CERN Document Server

    Vasseur, Romain; Dauxois, Thierry

    2008-01-01

    We present fluid dynamics videos of the motion of a boat on a two-layer or three-layer fluid. Under certain specific conditions, this setup generates large amplitude interfacial waves, while no surface waves are visible. The boat is slowed down leading to a peristaltic effect and sometimes even stopped: this is the so-called dead water phenomenon.

  19. Physiology of heartbeat reversal in adult Drosophila melanogaster (Diptera: Drosophilidae)

    Czech Academy of Sciences Publication Activity Database

    Sláma, Karel

    2010-01-01

    Roč. 107, č. 1 (2010), s. 13-31. ISSN 1210-5759 Institutional research plan: CEZ:AV0Z50070508 Keywords : peristaltic heart beat * synchronic heart beat * pulse-light optocardiography Subject RIV: ED - Physiology Impact factor: 0.945, year: 2010 http://www.eje.cz/scripts/viewabstract.php?abstract=1504

  20. Functional structural similarity between insect and human hearts: Electrocardiography of insect hearts for screening of new cardioactive drugs

    Czech Academy of Sciences Publication Activity Database

    Sláma, Karel; Aulický, R.; Lukáš, J.

    Bristol : IOP Publishing Ltd, 2013, s. 5-12. ISBN 978-989-8565-78-5. [Cardiotechnik 2013: International Congress on Cardiomuscular Technologies. Algarve (PT), 19.09.2013-21.09.2013] Grant ostatní: GA ČR(CZ) QJI310057 Institutional support: RVO:60077344 Keywords : peristaltic myocardial contractions * tubular heart * heart beat reversal Subject RIV: ED - Physiology

  1. [Two steps elution method FI on-line adsorption and preconcentration coupled with FAAS for the determination of trace zinc].

    Science.gov (United States)

    Wang, Zhong-yuan; Zhang, Hong-kang; Fang, Hong-da; Su, Yao-dong; Mittal, Gauri S

    2011-12-01

    A flow injection two steps elution method on-line sorption and preconcentration system coupled to flame atomic absorption spectrometry (FAAS) was developed for the determination of trace Zn in water samples. The conventional elution procedure was divided into two steps: elution procedure and detection procedure. During the elution procedure, the eluent was pumped into KR by the suction of the peristaltic pump and through PTFE tube instead of peristaltic pump tube. By the new method, the dispersion of the analyte was decreased notably, and high absorbance peak value was achieved. Because the eluent was not through the peristaltic pump tube, the peristaltic pump tube was protected from being eroded. Emptying procedure was added in order to insure the veracity and repeatability of the experiment of every time. With 60 s (sample throughput of 37 x h(-1)) of sampling at a flow rate of 6.0 mL x min(-1), an enhancement factor (EF) of 28 (higher than 9 achieved by conventional elution method) and a detection limit (3sigma) of 0.35 x L(-1) were obtained. The precision (RSD, n=11) was 2.1% at the 20 microg x L(-1) level. When 0.1% phi triethannolamine was used as masking reagent, the recovery rate was from 98.7% to 99.6%. PMID:22295800

  2. Long wavelength flow analysis in a curved channel

    Energy Technology Data Exchange (ETDEWEB)

    Ali, Nasir [Dept. of Mathematics, International Islamic Univ., Islamabad (Pakistan); Sajid, Muhammad [Theoretical Plasma Physics Div., PINSTECH, P.O. Nilore, Islamabad (Pakistan); Hayat, Tasawar [Dept. of Mathematics, Quaid-i-Azam Univ., Islamabad (Pakistan)

    2010-03-15

    This study is concerned with the peristaltic flow of a viscous fluid in a curved channel. Mathematically the problem is governed by two partial differential equations. Closed form solutions of the stream function, axial velocity, and pressure gradient are developed under long wavelength and low Reynolds number assumptions. The influence of curvature is analyzed on various flow quantities of interest. (orig.)

  3. Functional obstruction: the renal pelvis rules

    OpenAIRE

    Mendelsohn, Cathy

    2004-01-01

    Failure in the peristaltic mechanism that conducts urine from the kidney to the bladder can lead to hydronephrosis, a common birth defect associated with obstructive nephropathy. New animal models reveal molecular pathways important for peristalsis and point to the central role of the renal pelvis in urine transport.

  4. MR urography (MRU of non-dilated ureter with diuretic administration: Static fluid 2D FSE T2-weighted versus 3D gadolinium T1-weighted GE excretory MR

    Directory of Open Access Journals (Sweden)

    C. Roy

    2014-01-01

    Conclusion: T2-weighted MRU with multiple orientations and diuretic is sufficient to identify the non-dilated ureter. It offers information on ureteral peristaltism. It can be suggested that this sequence is able to detect an initial obstruction before hydronephrosis occurs.

  5. A valveless micro impedance pump driven by electromagnetic actuation

    OpenAIRE

    Rinderknecht, Derek; Hickerson, Anna Iwaniec; Gharib, Morteza

    2005-01-01

    Over the past two decades, a variety of micropumps have been explored for various applications in microfluidics such as control of pico- and nanoliter flows for drug delivery as well as chemical mixing and analysis. We present the fabrication and preliminary experimental studies of flow performance on the micro impedance pump, a previously unexplored method of pumping fluid on the microscale. The micro impedance pump was constructed of a simple thin-walled tube coupled at either end to glass ...

  6. Integrated micro-liquid dosing systems

    OpenAIRE

    Theo S.J. Lammerink; Elwenspoek, Miko; Fluitman, Jan H.J

    1993-01-01

    An integrated micro-liquid dosing system consisting of a micropump and a microliquid flow sensor is demonstrated. The dosing system allows accurate dosing of liquid in the microliter regime and can easily be integrated with components such as mixers and detectors in micro-liquid handling systems. The liquid pump is of the reciprocating type with a thermopneumatic actuator. The microliquid flow sensor is based on the thermal anemometer type. Both pump and flow sensor are realized in a 3-in (10...

  7. Experience with structural elements for controlling flow of radioactive and corrosive liquids

    International Nuclear Information System (INIS)

    A description is presented of manually operated cocks 2 mm in inner diameter, electromagnetic valves, tube bushings and plastic tube bushings, elements for joining tubes, a six-throw diaphragm pump with a separate delivery head, and micropumps. Operating experience is reported. The equipment described comprises the basic elements for the construction of laboratory facilities where corrosion or radioactive gases and liquids are handled. (J.P.)

  8. Performances analysis of a piezo-pump

    OpenAIRE

    Belkhiat S.; Benaissa A.

    2012-01-01

    Piezo-pumps, in the last decade, have received extensive attention because of their potential applications in biomedical devices, biological and chemical analysis, micro-electronics cooling and space exploration. In this paper an analytical model is developed to analysis the parameters effect on the pump flow. The micro-pump driven by piezostack (PZT alloy multilayer) as actuator is studied as function size and working middle. This one is compared with SCMCP pump actuated by PZT alloy as piez...

  9. A novel monolithic microactuator fabricated by 3D rapid direct manufacture

    OpenAIRE

    King, Philip; Covington, James

    2009-01-01

    In this paper we present the world’s first micropump entirely fabricated using a 3D direct manufacture process based on microstereolithography. The device employs a single pneumatically actuated membrane, with flow rectification provided by a nozzle/diffuser arrangement. A maximum flow rate of just over 2,000 ?l/min was achieved with a pneumatic pressure of 2 PSIG and a stroke rate of 96 Hz. The fabrication of actuator components using stereolithography apparatus (SLA) is a potentially major ...

  10. Design, characterization, and modeling of microcirculation systems with integrated oxygenators

    OpenAIRE

    Busek, Mathias; Gruenzner, Stefan; Steege, Tobias; Schmieder, Florian; Klotzbach, Udo; Sonntag, Frank

    2016-01-01

    Here, we describe a microfluidic system for hypoxia assays on human cell culture models. These systems are developed to replace or reduce animal testing in biomedical basic research. The presented system uses a gas-permeable membrane as a gas–liquid interface and a micropump for media actuation to influence the oxygen content in two cell culture chambers. To apply well-defined hypoxic conditions to the cells, a good understanding of the mass transport phenomena is necessary....

  11. A novel miniature dynamic microfluidic cell culture platform using electro-osmosis diode pumping

    OpenAIRE

    Chang, Jen-Yung; Wang, Shuo; Allen, Jeffrey S.; Lee, Seong Hyuk; Chang, Suk Tai; Choi, Young-Ki; Friedrich, Craig; Choi, Chang Kyoung

    2014-01-01

    An electro-osmosis (EOS) diode pumping platform capable of culturing cells in fluidic cellular micro-environments particularly at low volume flow rates has been developed. Diode pumps have been shown to be a viable alternative to mechanically driven pumps. Typically electrokinetic micro-pumps were limited to low-concentration solutions (≤10 mM). In our approach, surface mount diodes were embedded along the sidewalls of a microchannel to rectify externally applied alternating current into puls...

  12. High-speed pulsed mixing in a short distance with high-frequency switching of pumping from three inlets

    Science.gov (United States)

    Sugano, K.; Nakata, A.; Tsuchiya, T.; Tabata, O.

    2015-08-01

    In this study, we propose a mixing method using alternate pulsed flows from three inlets with flow direction control. In conventional pulsed mixing, a residual flow near the sidewalls inhibits the rapid mixing of two solutions at high switching frequency. In this study, we addressed this issue in order to perform rapid mixing in a short distance with a low Reynolds number. We fabricated a microfluidic mixing device consisting of a cross-shaped mixing channel with three inlet microchannels and three valveless micropumps. In conventional T-shaped or Y-shaped mixing channels, a residual flow is observed because of the incomplete switching of solutions. The three inlet configuration enabled us to split the residual flow at a switching frequency of pumping of up to 200 Hz, thus resulting in rapid mixing. Furthermore, by controlling the flow direction at the confluent area using the reverse flow of the micropump, the mixing speed was dramatically increased because of the complete switching of the two solutions. As a result, we achieved the mixing time of 3.6 ms and the mixing length of 20.7 µm, which were necessary to achieve a 90% mixing ratio at a high micropump switching frequency of 400 Hz and reverse flow ratio of 1/4.

  13. A microfluidic pump/valve inspired by xylem embolism and transpiration in plants.

    Directory of Open Access Journals (Sweden)

    Li Jingmin

    Full Text Available In plants, transpiration draws the water upward from the roots to the leaves. However, this flow can be blocked by air bubbles in the xylem conduits, which is called xylem embolism. In this research, we present the design of a biomimetic microfluidic pump/valve based on water transpiration and xylem embolism. This micropump/valve is mainly composed of three parts: the first is a silicon sheet with an array of slit-like micropores to mimic the stomata in a plant leaf; the second is a piece of agarose gel to mimic the mesophyll cells in the sub-cavities of a stoma; the third is a micro-heater which is used to mimic the xylem embolism and its self-repairing. The solution in the microchannels of a microfluidic chip can be driven by the biomimetic "leaf" composed of the silicon sheet and the agarose gel. The halting and flowing of the solution is controlled by the micro-heater. Results have shown that a steady flow rate of 1.12 µl/min can be obtained by using this micropump/valve. The time interval between the turning on/off of the micro-heater and the halt (or flow of the fluid is only 2∼3 s. This micropump/valve can be used as a "plug and play" fluid-driven unit. It has the potential to be used in many application fields.

  14. High-speed pulsed mixing in a short distance with high-frequency switching of pumping from three inlets

    International Nuclear Information System (INIS)

    In this study, we propose a mixing method using alternate pulsed flows from three inlets with flow direction control. In conventional pulsed mixing, a residual flow near the sidewalls inhibits the rapid mixing of two solutions at high switching frequency. In this study, we addressed this issue in order to perform rapid mixing in a short distance with a low Reynolds number. We fabricated a microfluidic mixing device consisting of a cross-shaped mixing channel with three inlet microchannels and three valveless micropumps. In conventional T-shaped or Y-shaped mixing channels, a residual flow is observed because of the incomplete switching of solutions. The three inlet configuration enabled us to split the residual flow at a switching frequency of pumping of up to 200 Hz, thus resulting in rapid mixing. Furthermore, by controlling the flow direction at the confluent area using the reverse flow of the micropump, the mixing speed was dramatically increased because of the complete switching of the two solutions. As a result, we achieved the mixing time of 3.6 ms and the mixing length of 20.7 µm, which were necessary to achieve a 90% mixing ratio at a high micropump switching frequency of 400 Hz and reverse flow ratio of 1/4. (paper)

  15. Miniature solid-state gas compressor

    Science.gov (United States)

    Lawless, William N.; Cross, Leslie E.; Steyert, William A.

    1985-01-01

    A miniature apparatus for compressing gases is disclosed in which an elastomer disposed between two opposing electrostrictive or piezoelectric ceramic blocks, or between a single electrostrictive or piezoelectric ceramic block and a rigid surface, is caused to extrude into or recede from a channel defined adjacent to the elastomer in response to application or removal of an electric field from the blocks. Individual cells of blocks and elastomer are connected to effect a gas compression by peristaltic activation of the individual cells. The apparatus is self-valving in that the first and last cells operate as inlet and outlet valves, respectively. Preferred electrostrictive and piezoelectric ceramic materials are disclosed, and an alternative, non-peristaltic embodiment of the apparatus is described.

  16. A kinematic study of pulsation in the dorsal blood vessel of the blackworm, Lumbriculus variegatus

    Directory of Open Access Journals (Sweden)

    Kameko Halfmann

    2011-01-01

    Full Text Available The aquatic oligochaete Lumbriculus variegatus has a segmented, dorsal blood vessel (DBV that acts as a peristaltic pump to move blood through the animal's closed circulatory system. We conducted a kinematic study using videography and computational modeling as a first step toward understanding the control of DBV pulsation. Results suggested that pulse rates were highest in the posterior segments, while interpulse intervals and intersegmental delays were longest in the midbody segments. Differences in the interpulse interval distributions across regions suggest that some peristaltic waves initiated in the posterior segments do not propagate all the way to the anterior segments. A simple model consisting of a chain of excitable neuromuscular units replicated these kinetics. This model may be useful in future research aimed at understanding the modulatory effect of biogenic amines on peristalsis of the DBV. Moreover, research into the mechanisms of peristalsis of the DBV may lead to insights into disorders of peristalsis in human and veterinary medicine

  17. A mathematical model of motorneuron dynamics in the heartbeat of the leech

    Science.gov (United States)

    Buono, Pietro-Luciano; Palacios, A.

    2004-02-01

    The heartbeat of the medicinal leech is driven by direct contact between two arrays of motorneurons and two lateral blood vessels. At any given time, motorneurons exhibit one of two alternating states so that, on one side of the animal, the heart beats in a rear-to-front fashion (peristaltic), while on the other side the heart beats synchronously. Every 20 heartbeats, approximately, the two sides switch modes. It is known that the heartbeat rhythm is generated through burst of oscillatory activity produced by a central pattern generator (CPG) network of neurons. However, to the best of our knowledge, how the CPG activity is translated into peristaltic and synchronous rhythms in the motorneurons is yet unknown. In this work, we use symmetric systems of differential equations, accompanied with computational simulations, to investigate possible mechanisms for generating the motorneuron activity that characterizes the heartbeat of leeches and in particular the switching scenario.

  18. Study of the Gastric Emptying in Humans: Biomagnetic Assessments

    Science.gov (United States)

    Hernández, E.; Córdova, T.; Huerta-Franco, R.; Sosa, M.; Vargas-Luna, M.

    2006-09-01

    Biomagnetic studies of the gastrointestinal system can be carried out in two ways. Recording the magnetic field produced by the myenteric nervous system or created by any oral contrast mean as magnetic tracers or markers. In the first case, a SQUID magnetometer is demanded while a fluxgate magnetometer is enough in the second case. In this work, a magnetic marker was ingested by 8 healthy volunteers, in three gastric volume conditions, to measure the luminal content volume effect in the gastric emptying and to perform the quantification of the peristaltic frequencies in gastric and duodenum tract segments. The average emptying times for low luminal content, relative to the emptying time when the intake was the highest, were 43.6 ± 15.6 % and 77.3 ± 47.0 %. These results show that the biomagnetic technique is a powerful modality to estimate the effects of the gastric volume in the gastric emptying and a way to record the peristaltic frequencies.

  19. New deep glass etching technology

    OpenAIRE

    Bu, M.; Melvin, T; Ensell, G; J. S. Wilkinson; Evans, A.G.R.

    2003-01-01

    A new masking technology useful for wet etching of glass, to a depth of more than 300 ?m, is reported; multilayers of metal in combination with thick SPRT220 photoresist, are used. This new method was successfully developed for fabricating a 200 ?m thick diaphragm for a micro peristaltic pump. Various mask materials, which can be patterned by standard photolithography and metal etching processes, were investigated. The main advantage of this newly developed method was the application of hydro...

  20. Collection of islets of Langerhans using an equilibrium method

    OpenAIRE

    Koh, Duk-Su; Moody, Mark; Jo, Junghyo

    2013-01-01

    Here we present a convenient method for easy hand-selection of enzymatically isolated small tissues such as islets. This method using a micropipette tip connected to a peristaltic pump collects islets in the tip continuously. After entering a conical micropipette tip, islets are quickly dragged up by solution flow, and this movement subsequently decreases as the flow rate decreases. The islets are trapped at a specific height when downward gravitation balances upward buoyancy and drag provide...

  1. Evaluation of blood compatibility of plasma deposited heparin-like films and SF6 plasma treated surfaces

    OpenAIRE

    Ivanira Antunes Perrenoud; Elidiane Cipriano Rangel; Rogério Pinto Mota; Steven Frederick Durrant; Nilson Cristino da Cruz

    2010-01-01

    In devices used in open-heart surgery and dialysis, blood must be continuously processed using extracorporeal circuits composed of peristaltic pumps and active components such as specific filters and oxygenators. Several procedures have been employed to avoid blood coagulation induced by contact with the artificial surfaces of such devices. Often heparin, a bioactive protein able to prevent clot formation, is employed. In this work, we have used heparin-containing gas plasmas to evaluate the ...

  2. Effects of cisapride on parameters of oesophageal motility and on the prolonged intraoesophageal pH test in infants with gastro-oesophageal reflux disease.

    OpenAIRE

    Cucchiara, S; Staiano, A.; Boccieri, A; De Stefano, M; Capozzi, C; Manzi, G.; Camerlingo, F; Paone, F M

    1990-01-01

    The effect of cisapride, a new gastrointestinal prokinetic drug, on oesophageal motility and acid reflux was studied in 14 children with gastro-oesophageal reflux disease, receiving either placebo or cisapride 0.15 mg/kg intravenously. Cisapride significantly (p less than 0.01) increased the lower oesophageal sphincter pressure (+124%), the amplitude (+84%) and duration (+24%) of oesophageal peristaltic waves, whereas the placebo treatment did not produce any changes. Subsequently, all 14 chi...

  3. Development of a auto-loading system for radioisotope liquor

    International Nuclear Information System (INIS)

    A loading system with computer distant control for radioisotope liquor is developed. It's arm to avoid close operating to the radioactive in the radioisotope liquor. Microcontroller is used as control center, step motor and peristaltic pump as manipulator in this system. The product process is performed with real-time measurement and control. The system has many function including data storage, data query, printing, operator information management, et al. (authors)

  4. Lactate dehydrogenase activity of rat epididymis and spermatozoa: Effect of constant light

    OpenAIRE

    RH Ponce; CS Carriazo; NT Vermouth

    2009-01-01

    During its passage through the epididymis, the gamete undergoes a process of “maturation” leading to the acquisition of its fertilizing ability. The epididymis displays regional variations in the morphology and metabolic properties of its epithelium which are relevant for the progressive development of mature sperm characteristics. The epididymis has spontaneous peristaltic contractions and receives sympathetic innervation that is modulated by melatonin, a hormone synthesized and ...

  5. Design of an Automated Flow Injection-Chemiluminescence Instrument Incorporating a Miniature Photomultiplier Tube for Monitoring Picomolar Concentrations of Iron in Seawater

    OpenAIRE

    Worsfold, Paul J.; Bowie, Andrew R.; Achterberg, Eric P.; Simon Ussher

    2005-01-01

    A flow-injection (FI)-based instrument under Lab VIEW control for monitoring iron in marine waters is described. The instrument incorporates a miniature, low-power photomultiplier tube (PMT), and a number of microelectric and solenoid actuated valves and peristaltic pumps. The software allows full control of all flow injection components and processing of the data from the PMT. The optimised system is capable of 20 injections per hour, including preconcentration and wash steps. The detection ...

  6. Flexible gastrointestinal motility pressure sensors based on aluminum thin-film strain-gauge arrays

    OpenAIRE

    Silva, Luís Rebelo; Sousa, Paulo J.; L.M. Gonçalves; Minas, Graça

    2015-01-01

    This paper reports on an innovative approach to measuring intraluminal pressure in the upper gastrointestinal (GI) tract, especially monitoring GI motility and peristaltic movements. The proposed approach relies on thin-film aluminum strain gauges deposited on top of a Kapton membrane, which in turn lies on top of an SU-8 diaphragm-like structure. This structure enables the Kapton membrane to bend when pressure is applied, thereby affecting the strain gauges and effectively cha...

  7. Multi-column step-gradient chromatography system for automated ion exchange separations

    International Nuclear Information System (INIS)

    A multi-column step-gradient chromatography system has been designed to perform automated sequential separations of radionuclides by ion exchange chromatography. The system consists of a digital programmer with automatic stream selection valve, two peristaltic pumps, ten columns, and a fraction collector. The automation allows complicated separations of radionuclides to be made with minimal analyst attention and allows for increased productivity and reduced cost of analyses. Results are reported for test separations on mixtures of radionuclides by the system

  8. Organ culture of fetal rat small intestine for testing gluten toxicity: a reappraisal.

    OpenAIRE

    Wood, G. M.; Howdle, P. D.; Losowsky, M. S.

    1987-01-01

    Jejunal segments from fetal rats of 18 days gestation were maintained in an organ culture system for up to 72 h. During this period, villi developed within the intestinal lumen and the epithelium changed from stratified to simple columnar. Peristaltic activity was observed during in-vitro culture. Alkaline phosphatase specific activity of the bowel segments fell after 48 hours culture, compared with pre-culture values (P less than 0.05), but that of alpha-glucosidase increased. The addition o...

  9. Sensitive and Real-Time Method for Evaluating Corneal Barrier Considering Tear Flow

    OpenAIRE

    Nakamura, Tadahiro; Teshima, Mugen; Kitahara, Takashi; Sasaki, Hitoshi; Uematsu, Masafumi; Kitaoka, Takashi; Nakashima, Mikiro; Nishida, Koyo; Nakamura, Junzo; Higuchi, Shun

    2010-01-01

    We developed a new electrophysiological method mimicking tear flow to evaluate the epithelial tight junction of rabbit cornea quantitatively. We investigated the effect of tear flow on the corneal damage induced by ophthalmic preservatives using this method. An Ussing chamber system with Ag/AgCl electrodes was used in the electrophysiological experiment. The excised rabbit cornea was mounted in the Ussing chamber and the precorneal solution in the chamber was perfused with a peristaltic pump ...

  10. Successful in vitro expansion and Characterization of Human Enteric Neuronal cells- A step towards Cell based therapies for Hirschsprung’s disease

    OpenAIRE

    Balamurugan M.; Preethy SP; Tholcopiyan L; Thamaraikannan; Srinivasan V; Murugan P; Manjunath S; Srinivasan T; Krishnamohan J; Abraham S

    2010-01-01

    BACKGROUND: The Enteric Nervous system (ENS) is a part of the Peripheral nervous system (PNS) that controls the peristaltic activity of the gut wall which is essential for propulsion of food in the digestive tract. It is composed of a large number of neurons and glial cells, distributed throughout the length of the gut. These ganglion cells develop from the neural crest in the embryo. Failure of complete colonization of the gut by these enteric neural crest cells during early development of l...

  11. Dynamic Theory of Pearling Instability in Cylindrical Vesicles

    OpenAIRE

    Nelson, Philip; Powers, Thomas; Seifert, Udo

    1994-01-01

    We give a simple theory for recent experiments of Bar-Ziv and Moses% Phys. Rev. Lett. {\\bf73} (1994) 1392, in which tubular vesicles are excited using laser tweezers to a ``peristaltic'' state. Considering the hydrodynamics of a bilayer membrane under tension, we reproduce some of the qualitative behavior seen and find a value for the wavelength of the instability in terms of independently measured material parameters, in rough agreement with the experimental values.

  12. A model of Stokesian peristalsis and vesicle transport in a three-dimensional closed cavity.

    Science.gov (United States)

    Aranda, Vivian; Cortez, Ricardo; Fauci, Lisa

    2015-06-25

    The complexity of the mechanics involved in the mammalian reproductive process is evident. Neither an ovum nor an embryo is self-propelled, but move through the oviduct or uterus due to the peristaltic action of the tube walls, imposed pressure gradients, and perhaps ciliary motion. Here we use the method of regularized Stokeslets to model the transport of an ovum or an embryo within a peristaltic tube. We represent the ovum or the embryo as a spherical vesicle of finite volume - not a massless point particle. The outer membrane of the neutrally buoyant vesicle is discretized by nodes that are joined by a network of springs. The elastic moduli of these springs are chosen large enough so that a spherical shape is maintained. For simplicity, here we choose an axisymmetric tube where the geometry of the two-dimensional cross-section along the tube axis reflects that of the sagittal cross-section of the uterine cavity. Although the tube motion is axisymmetric, the presence of the vesicle within the tube requires a fully three-dimensional model. As was found in Yaniv et al. (2009, 2012) for a 2D closed channel, we find that the flow dynamics in a 3D peristaltic tube are strongly influenced by the closed end and the manner in which the peristaltic wave damps out towards the closure. In addition, we demonstrate that the trajectory of a vesicle of finite volume can greatly differ from the trajectory of a massless fluid particle initially placed at the vesicle׳s centroid. PMID:25817334

  13. A Continuous Flow System for the Measurement of Ambient Nitrogen Oxides [NO + NO2] Using Rhodamine B Hydrazide as a Chemosensor

    OpenAIRE

    Pandurangappa Malingappa; Venkataramanappa Yarradoddappa

    2014-01-01

    A new chemosensor has been used to monitor atmospheric nitrogen oxides [NO + NO2] at parts per billion (ppb) level. It is based on the catalytic reaction of nitrogen oxides with rhodamine B hydrazide (RBH) to produce a colored compound through the hydrolysis of the amide bond of the molecule. A simple colorimeter has been used to monitor atmospheric nitrogen dioxide at ppb level. The air samples were purged through a sampling cuvette containing RBH solution using peristaltic pump. The propose...

  14. Oesophageal food impaction in achalasia treated with Coca-Cola and nifedipine

    OpenAIRE

    Koumi, Andriani; Panos, Marios Zenon

    2010-01-01

    Achalasia is characterised by the loss of peristaltic movement in the distal oesophagus and failure of the lower oesophageal sphincter relaxation, which results in impaired oesophageal emptying. We report a case of a 92-year-old frail woman with a history of achalasia, who presented with acute oesophageal obstruction due to impaction of a large amount of food material. She was treated successfully with nifedipine, in combination with Coca-Cola (original product, not sugar free), so avoiding t...

  15. Magnetohydrodynamic flow of a Carreau fluid in an channel with different wave forms

    Energy Technology Data Exchange (ETDEWEB)

    Hayat, Tasawar [Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Mathematics; King Saud Univ., Riyadh (Saudi Arabia). Dept. of Mathematics; Saleem, Najma [Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Mathematics; Mesloub, Said [King Saud Univ., Riyadh (Saudi Arabia). Dept. of Mathematics; Ali, Nasir [International Islamic Univ., Islamabad (Pakistan). Faculty of Basic and Applied Sciences

    2011-03-15

    In this investigation, we discuss the peristaltic motion based on the constitutive equations of a Carreau fluid in a channel. The fluid is electrically conducting in the presence of a uniform applied magnetic field. Four different wave forms are chosen. The fluid behaviour is studied using long wavelength approximation. Detailed analysis is performed for various emerging parameters on pumping and trapping phenomena. The present results reduce favourably with the currently available results of hydrodynamic case when the Hartman number is chosen zero. (orig.)

  16. Flow of MHD Carreau Fluid in a Curved Channel

    Directory of Open Access Journals (Sweden)

    Saima Noreen

    2013-01-01

    Full Text Available Analysis has been made for the curvature effects on the MHD peristaltic flow of an incompressible Carreau fluid in a channel. The flow problem is first reduced in the wave frame of reference and then solved after employing the long wavelength and low Reynolds number approximations. Expressions of stream function, pressure gradient, magnetic force function, induced magnetic field and current density are derived and then examined for various parameters of interest.

  17. Single column sequential extraction of Ra, Nd, Th, Pa and U from a natural sample

    OpenAIRE

    Jeandel, C.; Venchiarutti, C.; Bourquin, M.; Pradoux, C; Lacan, F.; P. van Beek; Riotte, Jean

    2011-01-01

    A new procedure allowing the sequential extraction of Ra, Nd, Th, Pa and U from the same initial natural sample (sea or river waters, particles, sediments, rocks) is proposed. Extraction recoveries were better than 90%. Procedural blanks ranged from 80 pg (for Nd) to below 1 fg, the detection limit of the MC-ICP-MS used (for Pa); all were negligible compared with the amounts of elements currently determined. Based on classical anionic resins attached to a peristaltic pump allowing precise flo...

  18. Slime mould electronic oscillators

    OpenAIRE

    Adamatzky, Andrew

    2014-01-01

    We construct electronic oscillator from acellular slime mould Physarum polycephalum. The slime mould oscillator is made of two electrodes connected by a protoplasmic tube of the living slime mould. A protoplasmic tube has an average resistance of 3~MOhm. The tube's resistance is changing over time due to peristaltic contractile activity of the tube. The resistance of the protoplasmic tube oscillates with average period of 73~sec and average amplitude of 0.6~MOhm. We present experimental labor...

  19. Bidirectional Propulsion of Devices Along the Gastrointestinal Tract Using Electrostimulation

    OpenAIRE

    Burke, M. P. D.

    2013-01-01

    This thesis describes a method for propelling devices such as video capsule endoscopes in either direction along the small intestines using electrostimulation-induced muscular contractions. When swallowed, passive diagnostic ‘one-shot’ devices rely on sporadic peristaltic movement, possibly missing vital ‘areas of interest’. This bidirectional propulsion method provides active control for that all-important ‘second look’. Design considerations, within the dimensional constraints, required a d...

  20. Analysis and Implementation of Multiple Bionic Motion Patterns for Caterpillar Robot Driven by Sinusoidal Oscillator

    OpenAIRE

    Yanhe Zhu; Xiaolu Wang; Jizhuang Fan; Sajid Iqbal; Dongyang Bie; Jie Zhao

    2014-01-01

    Articulated caterpillar robot has various locomotion patterns—which make it adaptable to different tasks. Generally, the researchers have realized undulatory (transverse wave) and simple rolling locomotion. But many motion patterns are still unexplored. In this paper, peristaltic locomotion and various additional rolling patterns are achieved by employing sinusoidal oscillator with fixed phase difference as the joint controller. The usefulness of the proposed method is verified using simulati...

  1. On the Feasibility of Steering Swallowable Microsystem Capsules Using Computer-Aided Magnetic Levitation

    OpenAIRE

    Wu, Billy; Mintchev, Martin

    2008-01-01

    Swallowable capsule endoscopy is used for non-invasive diagnosis of some gastrointestinal (GI) organs. However, control over the position of the capsule is a major unresolved issue. This study presents a design for steering the capsule based on magnetic levitation. The levitation is stabilized with the aid of a computer-aided feedback control system and diamagnetism. Peristaltic and gravitational forces to be overcome were calculated. A levitation setup was built to analyze the fe...

  2. In Vitro Testing of a Novel Blood Pump Designed for Temporary Extracorporeal Support

    OpenAIRE

    Spurlock, DJ; Ranney, DN; Fracz, E; Mazur,; Bartlett, RH; Haft, JW

    2012-01-01

    Extracorporeal blood pumps are used as temporary ventricular assist devices or for extracorporeal membrane oxygenation. The ideal pump would be intrinsically self-regulating, carry no risk of cavitation or excessive inlet suction, be afterload insensitive, and valveless thus reducing thrombogenicity. Currently used technology, including roller, centrifugal, and pneumatic pulsatile pumps, does not meet these requirements. We studied a non-occlusive peristaltic pump (M-Pump) in two mock circula...

  3. Frequency Behavior of a Quartz Crystal Microbalance (Qcm) in Contact with Selected Solutions

    OpenAIRE

    Z. A. Talib; Z. Baba; Kurosawa, S.; H. A.A. Sidek; A. Kassimb; W. M.M. Yunus

    2006-01-01

    A device was constructed to monitor viscosity of solutions using fundamental frequency of 9 MHz and 10 MHz quartz crystal. Piezoelectric quartz crystals with gold electrodes were mounted by O-ring in between liquid flow cell. Only one side of the crystal was exposed to the solutions which were pumped through silicon tube by a peristaltic pump. The measured frequency shift was observed in order to investigate the interfacial behavior of some selected solution in contact with one surface of Qua...

  4. LabVIEW-based sequential-injection analysis system for the determination of trace metals by square-wave anodic and adsorptive stripping voltammetry on mercury-film electrodes

    OpenAIRE

    Anastasios Economou; Anastasios Voulgaropoulos

    2003-01-01

    The development of a dedicated automated sequential-injection analysis apparatus for anodic stripping voltammetry (ASV) and adsorptive stripping voltammetry (AdSV) is reported. The instrument comprised a peristaltic pump, a multiposition selector valve and a home-made potentiostat and used a mercury-film electrode as the working electrodes in a thin-layer electrochemical detector. Programming of the experimental sequence was performed in LabVIEW 5.1. The sequence of operations included format...

  5. Effects of anti-hypertensive drugs on esophageal body contraction

    Institute of Scientific and Technical Information of China (English)

    Koichi; Yoshida; Kenji; Furuta; Kyoichi; Adachi; Shunji; Ohara; Terumi; Morita; Takashi; Tanimura; Shuji; Nakata; Masaharu; Miki; Kenji; Koshino; Yoshikazu; Kinoshita

    2010-01-01

    AIM:To clarify the effects of anti-hypertensive drugs on esophageal contraction and determine their possi-ble relationship with gastro-esophageal reflux disease.METHODS:Thirteen healthy male volunteers were enrolled. Esophageal body peristaltic contractions and lower esophageal sphincter (LES) pressure were measured using high resolution manometry. All subjects were randomly examined on four separate occasions following administrations of nifedipine,losartan,and atenolol,as well as without any drug administ...

  6. Function of longitudinal vs circular muscle fibers in esophageal peristalsis, deduced with mathematical modeling

    Institute of Scientific and Technical Information of China (English)

    James G Brasseur; Mark A Nicosia; Anupam Pal; Larr S Miller

    2007-01-01

    We summarize from previous works the functions of circular vs. longitudinal muscle in esophageal peristaltic bolus transport using a mix of experimental data, the conservation laws of mechanics and mathematical modeling. Whereas circular muscle tone generates radial closure pressure to create a local peristaltic closure wave, longitudinal muscle tone has two functions, one physiological with mechanical implications, and one purely mechanical. Each of these functions independently reduces the tension of individual circular muscle fibers to maintain closure as a consequence of shortening of longitudinal muscle locally coordinated with increasing circular muscle tone. The physiological function is deduced by combining basic laws of mechanics with concurrent measurements of intraluminal pressure from manometry, and changes in cross sectional muscle area from endoluminal ultrasound from which local longitudinal shortening (LLS) can be accurately obtained. The purely mechanical function of LLS was discovered from mathematical modeling of peristaltic esophageal transport with the axial wall motion generated by LLS. Physiologically, LLS concentrates circular muscle fibers where closure pressure is highest.However, the mechanical function of LLS is to reduce the level of pressure required to maintain closure. The combined physiological and mechanical consequences of LLS are to reduce circular muscle fiber tension and power by as much as 1/10 what would be required for peristalsis without the longitudinal muscle layer, a tremendous benefit that may explain the existence of longitudinal muscle fiber in the gut. We also review what is understood of the role of longitudinal muscle in esophageal emptying, reflux and pathology.

  7. STUDY ON 52 PATIENTS WITH ACUTE SEVERE ORGANOPHOSPHORUS PESTICIDE POISONING%急性重度有机磷中毒52例临床研究

    Institute of Scientific and Technical Information of China (English)

    孟瑞; 卢敏

    2011-01-01

    Objective To evaluate the clinical application of hemoperfusion combined with hemodialysis and continuous micropump infusion of atropine in the treatment of acute severe organophosphorus pesticide poisoning( ASOPP ). Methods A total of 104 patients with ASOPP were retrospectively analysed, all patients were treated with gastric lavage and so on, the treated group adopted hemoperfusion combined with hemodialysis and continuous micropump infusion of atropine in addition to basic therapy. The clinical data was compared. Results The treated group was superior to the control group in time from coma to consciousness, total amount of atropine and recovery time of cholinesterase etc. The recovery rate was 84.6%. Conclusion It is effective to apply hemoperfusion combined with hemodialysis and continuous micropump iffusion of atropine in rescuing the acute severe organophosphorus pesticide poisoning.%目的 评价血液灌流联合血液透析、阿托品微量泵持续泵入治疗急性重度有机磷中毒(acute severe organophosphorus pesticide poisoning,ASOPP)的临床应用价值.方法 对104例ASOPP患者进行回顾性分析,所有患者均给予洗胃等治疗,治疗组在对照组基础上加用血液灌流联合血液透析、阿托品微量泵治疗,比较2组各项临床资料.结果 治疗组昏迷至清醒时间、阿托品总量、胆碱酯酶恢复时间等明显优于对照组,治愈率为84.6%.结论 应用血液灌流联合血液透析、阿托品微量泵治疗ASOPP效果较好.

  8. A Microfluidic Pump/Valve Inspired by Xylem Embolism and Transpiration in Plants

    OpenAIRE

    Li Jingmin; Liu Chong; Xu Zheng; Zhang Kaiping; Ke Xue; Wang Liding

    2012-01-01

    In plants, transpiration draws the water upward from the roots to the leaves. However, this flow can be blocked by air bubbles in the xylem conduits, which is called xylem embolism. In this research, we present the design of a biomimetic microfluidic pump/valve based on water transpiration and xylem embolism. This micropump/valve is mainly composed of three parts: the first is a silicon sheet with an array of slit-like micropores to mimic the stomata in a plant leaf; the second is a piece of ...

  9. Analysis of Asymmetric Piezoelectric Composite Beam

    CERN Document Server

    Chen, J -S; Wu, K -C

    2008-01-01

    This paper deals with the vibration analysis of an asymmetric composite beam composed of glass a piezoelectric material. The Bernoulli's beam theory is adopted for mechanical deformations, and the electric potential field of the piezoelectric material is assumed such that the divergence-free requirement of the electrical displacements is satisfied. The accuracy of the analytic model is assessed by comparing the resonance frequencies obtained by the analytic model with those obtained by the finite element method. The model developed can be used as a tool for designing piezoelectric actuators such as micro-pumps.

  10. Topology optimisation of natural convection problems

    DEFF Research Database (Denmark)

    Alexandersen, Joe; Aage, Niels; Andreasen, Casper Schousboe;

    2014-01-01

    This paper demonstrates the application of the density-based topology optimisation approach for the design of heat sinks and micropumps based on natural convection effects. The problems are modelled under the assumptions of steady-state laminar flow using the incompressible Navier-Stokes equations...... coupled to the convection-diffusion equation through the Boussinesq approximation. In order to facilitate topology optimisation, the Brinkman approach is taken to penalise velocities inside the solid domain and the effective thermal conductivity is interpolated in order to accommodate differences in...

  11. Modeling and Simulation Framework for Flow-Based Microfluidic Biochips

    DEFF Research Database (Denmark)

    Schmidt, Morten Foged; Minhass, Wajid Hassan; Pop, Paul; Madsen, Jan

    2013-01-01

    several microvalves, more complex units, such as micropumps, switches, mixers, and multiplexers, can be built. Such biochips are becoming increasingly complex, with thousands of components, but are still designed manually using a bottom-up full-custom design approach, which is extremely labor intensive...... and error prone. In this paper, we present an Integrated Development Environment (IDE), which addresses (i) schematic capture of the biochip architecture and biochemical application, (ii) logic simulation of an application running on a biochip, and is able to integrate the high level synthesis tasks...

  12. Pin count-aware biochemical application compilation for mVLSI biochips

    DEFF Research Database (Denmark)

    Lander Raagaard, Michael; Pop, Paul

    2015-01-01

    are controlled from external pressure sources, connected to “control pins”. By combining several microvalves, more complex units, such as micropumps, switches, mixers, and multiplexers, can be built. The current practice is to design these biochips by hand in drawing tools such as AutoCAD, and to program them...... manually by individually controlling each valve. Recent research has proposed top-down physical synthesis Computer- Aided Design tools, and programming languages and compilation techniques to automatically derive the control signals for the valve actuations. However, researchers have so far assumed...

  13. A Disposable Polymer Lab-On-A-Slide For Point-Of-Care Diagnostics Of Methicillin-Resistant Staphylococcus Aureus (Mrsa)

    DEFF Research Database (Denmark)

    Bu, Minqiang; R. Perch-Nielsen, Ivan; Skov, Julia;

    2013-01-01

    This paper reports the design, fabrication and experimental verification of a polymer microfluidic labon-a-slide for rapid detection of methicillin-resistant Staphylococcus aureus (MRSA). MRSA cells were captured in a lysis chamber using magnetic beads, followed by thermal lysis. The released DNA...... was transferred into a second chamber for polymerase chain reaction (PCR) amplification. Fluidic control in the device was accomplished by pneumatic actuation of a micropump and five microvalves integrated on the device. The mecA gene from MRSA was successfully amplified by real-time PCR within 35 min...

  14. A Digitally Controllable Polymer-Based Microfluidic Mixing Module Array

    Directory of Open Access Journals (Sweden)

    Raymond H. W. Lam

    2012-03-01

    Full Text Available This paper presents an integrated digitally controllable microfluidic system for continuous solution supply with a real-time concentration control. This system contains multiple independently operating mixing modules, each integrated with two vortex micropumps, two Tesla valves and a micromixer. The interior surface of the system is made of biocompatible materials using a polymer micro-fabrication process and thus its operation can be applied to chemicals and bio-reagents. In each module, pumping of fluid is achieved by the vortex micropump working with the rotation of a micro-impeller. The downstream fluid mixing is based on mechanical vibrations driven by a lead zirconate titanate ceramic diaphragm actuator located below the mixing chamber. We have conducted experiments to prove that the addition of the micro-pillar structures to the mixing chamber further improves the mixing performance. We also developed a computer-controlled automated driver system to control the real-time fluid mixing and concentration regulation with the mixing module array. This research demonstrates the integration of digitally controllable polymer-based microfluidic modules as a fully functional system, which has great potential in the automation of many bio-fluid handling processes in bio-related applications.

  15. Microactuator using fluid materialization of high output micro machines

    International Nuclear Information System (INIS)

    Many kinds of microactuators using functional fluids such as ERF (Electro-Rheological Fluids), MRF (Magneto-Rheological Fluids) and ECF (Electro-Conjugate Fluids) have been studied. Some examples of them are stated. A valve-integrated microactuator using particle dispersion ER fluids, homogeneous ER fluids, and EC fluids and micropump, which were investigated by authors, are stated. The flow characteristics of ERF, micro ER valve with 3 ports, the valve-integrated microactuator using ER fluids, the control system of micro position using homogeneous ERF, structure of 3kinds of EFC motors and micro-pumps are illustrated and explained. The particle dispersion ERF, of which coefficient of viscosity is 0.22 Pa ·s at 26degC, consists of the high specific gravity silicon oil with 30wt% composite materials having diameter of 8μm. The micro ER valve showed 0.25MPa pressure change under the conditions of 0.4 MPa pressure and 5.0 kV/mm sum of electric field strength of electrode between the upper and the lower stream. (S.Y.)

  16. Implementation of Synchronous Micromotor in Developing Integrated Microfluidic Systems

    Directory of Open Access Journals (Sweden)

    Ala'aldeen Al-Halhouli

    2014-07-01

    Full Text Available This paper introduces the synchronous micromotor concept and presents new investigations on its application as an integrated driving mechanism in microfluidic systems. A spiral channel viscous micropump and a microstirrer are considered and tested as examples to verify the concept. The fabrication technology of such integrated systems is based on UV depth lithography, electroplating and soft lithography. The synchronous micromotor consists of a stator including double layer coils, and a rotor disk containing alternate permanent magnets. The coils are distributed evenly around the stator and arranged in three phases. The phases are excited by sinusoidal currents with a corresponding phase shift resulting in a rotating magnetic field. Regarding the spiral channel viscous micropump, a spiral disk was fixed onto the rotor disk and run at different rotational speeds. Tests showed very promising results, with a flow rate up to 1023 µL·min−1 at a motor rotational speed of 4500 rpm. Furthermore, for the application of a microstirred-tank bioreactor, the rotor disk design was modified to work as a stirrer. The performance of the developed microbioreactor was tested over a time period of approximately 10 h under constant stirring. Tests demonstrated the successful cultivation of S. cerevisiae through the integration of the microstirrer in a microbioreactor system. These systems prove that synchronous micromotors are well suited to serve as integrated driving mechanisms of active microfluidic components.

  17. Two-photon induced polymerization of photo-driven microsensors

    Science.gov (United States)

    Lin, Chih-Lang; Wang, Irene; Bouriau, Michel; Casalegno, Roger; Andraud, Chantal; Baldeck, Patrice L.

    2004-10-01

    We report on the fabrication of photo-driven polymer microsensors for viscosimetry, velocimetry and micropump applications. They are readily made with a low-cost polymerization technique based on two-photon absorption. Microsensors are free-floating in the liquid to be characterized. A linearly-polarized optical tweezers is used to trap one sensor at the laser focal point and to generate the optical torque needed for local hydrodynamic measurements. Viscosity and velocity microsensors have slab shapes that align in the polarization direction. The local viscosity is deduced from the maximum rotation frequency generated by the rotating linear polarization, while the fluid velocity is obtained by measuring the maximum angle that equilibrates the optical torque and drag torque. Experimental results are in good agreement with theoretical calculations. The micropump is based on a micron-size Archimedes screw that rotates around its long axis when it is trapped at the focal point. The laser-induced rotation is due to the optical torque that is transferred by the laser scattering on the screw.

  18. Contactless microfluidic pumping using microchannel-integrated carbon black composite membranes.

    Science.gov (United States)

    Fu, Xiaotong; Gagnon, Zachary

    2015-09-01

    The ability to pump and manipulate fluid at the micron-scale is a basic requirement for microfluidic platforms. Many current manipulation methods, however, require expensive and bulky external supporting equipment, which are not typically compatible for portable applications. We have developed a contactless metal electro-osmotic micropump capable of pumping conductive buffers. The pump operates using two pairs of gallium metal electrodes, which are activated using an external voltage source and separated from a main flow channel by a thin micron-scale polydimethylsiloxane (PDMS) membrane. The thin contactless membrane allows for field penetration and electro-osmotic flow within the microchannel, but eliminates electrode damage and sample contamination commonly associated with traditional DC electro-osmotic pumps that utilize electrodes in direct contact with the working fluid. Our previous work has demonstrated the effectiveness of this method in pumping deionized water. However, due to the high resistivity of PDMS, this method proved difficult to apply towards manipulating conductive buffers. To overcome this limitation, we fabricated conductive carbon black (CB) powder directly into the contactless PDMS membranes. The increased electrical conductivity of the contactless PDMS membrane significantly increased micropump performance. Using a microfluidic T-channel device and an electro-osmotic flow model, we determined the influence that CB has on pump pressure for CB weight percents varying between 0 and 20. The results demonstrate that the CB increases pump pressure by two orders of magnitude and enables effective operations with conductive buffers. PMID:26543514

  19. A pulsed sequential injection analysis flow system for the fluorimetric determination of indomethacin in pharmaceutical preparations

    International Nuclear Information System (INIS)

    This works reports the development of a pulsed flow sequential injection analysis (SIA) system based on the utilisation of pulse generating solenoid micro-pumps, which replace the conventional solutions propelling units commonly used in SIA systems. The influence on sample/reagent zones interpenetration and reaction zone formation of the reproducible pulsed flow produced by micro-pumps operation, which is characterised by a chaotic solutions movement, was comparatively evaluated with the typical laminar flow conditions of conventional SIA systems. The enhanced sample/reagent mixing provided by the controlled pulsed flow was favourably applied in the implementation of a SIA methodology for the fluorimetric determination of indomethacin in pharmaceutical preparations upon alkaline hydrolysis in micellar medium. Linear calibration plots were obtained for indomethacin concentrations up to 10-5 mol l-1 with a 3σ detection limit of about 1.6 x 10-8 mol l-1. The obtained results complied with those furnished by the reference procedure (RD ≤ 2.3%) and exhibited good reproducibility (RSD < 1.2%, n = 15). Sampling rate was about 30 samples per hour

  20. Automated microfluidic DNA/RNA extraction with both disposable and reusable components

    International Nuclear Information System (INIS)

    An automated microfluidic nucleic extraction system was fabricated with a multilayer polydimethylsiloxane (PDMS) structure that consists of sample wells, microvalves, a micropump and a disposable microfluidic silica cartridge. Both the microvalves and micropump structures were fabricated in a single layer and are operated pneumatically using a 100 µm PDMS membrane. To fabricate the disposable microfluidic silica cartridge, two-cavity structures were made in a PDMS replica to fit the stacked silica membranes. A handheld controller for the microvalves and pumps was developed to enable system automation. With purified ribonucleic acid (RNA), whole blood and E. coli samples, the automated microfluidic nucleic acid extraction system was validated with a guanidine-based solid phase extraction procedure. An extraction efficiency of ∼90% for deoxyribonucleic acid (DNA) and ∼54% for RNA was obtained in 12 min from whole blood and E. coli samples, respectively. In addition, the same quantity and quality of extracted DNA was confirmed by polymerase chain reaction (PCR) amplification. The PCR also presented the appropriate amplification and melting profiles. Automated, programmable fluid control and physical separation of the reusable components and the disposable components significantly decrease the assay time and manufacturing cost and increase the flexibility and compatibility of the system with downstream components

  1. Fabrication of plastic microfluidic components

    Science.gov (United States)

    Martin, Peter M.; Matson, Dean W.; Bennett, Wendy D.; Hammerstrom, D. J.

    1998-09-01

    Plastic components have many advantages, including ease of fabrication, low cost, chemical inertness, lightweight, and disposability. We report on the fabrication of three plastics-based microfluidic components: a motherboard, a dialysis unit, and a metal sensor. Microchannels, headers, and interconnects were produced in thin sheets (>=50 microns) of polyimide, PMMA, polyethylene, and polycarbonate using a direct-write excimer laser micromachining system. Machined sheets were laminated by thermal and adhesive bonding to form leak-tight microfluidic components. The microfluidic motherboard borrowed the `functionality on a chip' concept from the electronics industry and was the heart of a complex microfluidic analytical device. The motherboard platform was designed to be tightly integrated and self-contained (i.e., liquid flows are all confined within machined microchannels), reducing the need for tubing with fluid distribution and connectivity. This concept greatly facilitated system integration and miniaturization. As fabricated, the motherboard consisted of three fluid reservoirs connected to micropumps by microchannels. The fluids could either be pumped independently or mixed in microchannels prior to being directed to exterior analytical components via outlet ports. The microdialysis device was intended to separate electrolytic solutes from low volume samples prior to mass spectrometric analysis. The device consisted of a dialysis membrane laminated between opposed serpentine microchannels containing the sample fluid and a buffer solution. The laminated metal sensor consisted of fluid reservoirs, micro-flow channels, micropumps, mixing channels, reaction channels, and detector circuitry.

  2. Use of Buckling Instabilities in Micro Pumps, Valves, and Mixers

    Science.gov (United States)

    Tavakol, Behrouz; Chawan, Aschvin; Holmes, Douglas

    2014-03-01

    We use the buckling of thin, flexible plates for pumping fluids, controlling the flow rate, and mixing different media within a microfluidic channel. A dielectric elastomeric film with a confined geometry buckles out of the plane when exposed to an electric field. Solid or grease electrodes have traditionally been used as conductive materials to aid in voltage application to both sides of the film. In this work, we use an electrolytic fluid solution as the electrode to enable buckling at relatively low voltages, and to enhance the rate of deformation. We show that this mechanism can be implemented as a microvalve that controls flow rate, or as a micropump that operates over a range of frequencies. A similar mechanism can be used to aid diffusion between two adjacent laminar streams and improve mixing. These low-cost micropumps, microvalves, and micromixers rely on the reversible buckling of thin plates, are easily embeddable in a microfluidic chip, and can potentially be used in variety of applications to accurately control and manipulate fluid flow in a microchannel.

  3. High-throughput and clogging-free microfluidic filtration platform for on-chip cell separation from undiluted whole blood.

    Science.gov (United States)

    Cheng, Yinuo; Ye, Xiongying; Ma, Zengshuai; Xie, Shuai; Wang, Wenhui

    2016-01-01

    Rapid separation of white blood cells from whole blood sample is often required for their subsequent analyses of functions and phenotypes, and many advances have been made in this field. However, most current microfiltration-based cell separation microfluidic chips still suffer from low-throughput and membrane clogging. This paper reports on a high-throughput and clogging-free microfluidic filtration platform, which features with an integrated bidirectional micropump and commercially available polycarbonate microporous membranes. The integrated bidirectional micropump enables the fluid to flush micropores back and forth, effectively avoiding membrane clogging. The microporous membrane allows red blood cells passing through high-density pores in a cross-flow mixed with dead-end filtration mode. All the separation processes, including blood and buffer loading, separation, and sample collection, are automatically controlled for easy operation and high throughput. Both microbead mixture and undiluted whole blood sample are separated by the platform effectively. In particular, for white blood cell separation, the chip recovered 72.1% white blood cells with an over 232-fold enrichment ratio at a throughput as high as 37.5 μl/min. This high-throughput, clogging-free, and highly integrated platform holds great promise for point-of-care blood pretreatment, analysis, and diagnosis applications. PMID:26909124

  4. Micro space power system using MEMS fuel cell for nano-satellites

    Science.gov (United States)

    Lee, Jongkwang; Kim, Taegyu

    2014-08-01

    A micro space power system using micro fuel cell was developed for nano-satellites. The power system was fabricated using microelectromechanical system (MEMS) fabrication technologies. Polymer electrolyte membrane (PEM) fuel cell was selected in consideration of space environment. Sodium borohydride (NaBH4) was selected as a hydrogen source while hydrogen peroxide (H2O2) was selected as an oxygen source. The power system consists of a micro fuel cell, micro-reactor, micro-pump, and fuel cartridges. The micro fuel cell was fabricated on a light-weight and corrosion-resistant glass plates. The micro-reactor was used to generate hydrogen from NaBH4 alkaline solution via a catalytic hydrolysis reaction. All components such as micro-pump, fuel cartridges, and auxiliary battery were integrated for a complete power system. The storability of NaBH4 solution was evaluated at -25 °C and the performance of the micro power system was measured at various operating conditions. The power output of micro power system reasonably followed up the given electric load conditions.

  5. A conductivity-based interface tracking method for microfluidic application

    Science.gov (United States)

    Salgado, Juan David; Horiuchi, Keisuke; Dutta, Prashanta

    2006-05-01

    A novel conductivity-based interface tracking method is developed for 'lab-on-a-chip' applications to measure the velocity of the liquid-gas boundary during the filling process. This interface tracking system consists of two basic components: a fluidic circuit and an electronic circuit. The fluidic circuit is composed of a microchannel network where a number of very thin electrodes are placed in the flow path to detect the location of the liquid-gas interface in order to quantify the speed of a traveling liquid front. The electronic circuit is placed on a microelectronic chip that works as a logical switch. This interface tracking method is used to evaluate the performance of planar electrokinetic micropumps formed on a hybrid poly-di-methyl-siloxane (PDMS)-glass platform. In this study, the thickness of the planar micropump is set to be 10 µm, while the externally applied electric field is ranged from 100 V mm-1 to 200 V mm-1. For a particular geometric and electrokinetic condition, repeatable flow results are obtained from the speed of the liquid-gas interface. Flow results obtained from this interface tracking method are compared to those of other existing flow measuring techniques. The maximum error of this interface tracking sensor is less than 5%, even in an ultra low flow velocity.

  6. Automated microfluidic DNA/RNA extraction with both disposable and reusable components

    Science.gov (United States)

    Kim, Jungkyu; Johnson, Michael; Hill, Parker; Sonkul, Rahul S.; Kim, Jongwon; Gale, Bruce K.

    2012-01-01

    An automated microfluidic nucleic extraction system was fabricated with a multilayer polydimethylsiloxane (PDMS) structure that consists of sample wells, microvalves, a micropump and a disposable microfluidic silica cartridge. Both the microvalves and micropump structures were fabricated in a single layer and are operated pneumatically using a 100 µm PDMS membrane. To fabricate the disposable microfluidic silica cartridge, two-cavity structures were made in a PDMS replica to fit the stacked silica membranes. A handheld controller for the microvalves and pumps was developed to enable system automation. With purified ribonucleic acid (RNA), whole blood and E. coli samples, the automated microfluidic nucleic acid extraction system was validated with a guanidine-based solid phase extraction procedure. An extraction efficiency of ~90% for deoxyribonucleic acid (DNA) and ~54% for RNA was obtained in 12 min from whole blood and E. coli samples, respectively. In addition, the same quantity and quality of extracted DNA was confirmed by polymerase chain reaction (PCR) amplification. The PCR also presented the appropriate amplification and melting profiles. Automated, programmable fluid control and physical separation of the reusable components and the disposable components significantly decrease the assay time and manufacturing cost and increase the flexibility and compatibility of the system with downstream components.

  7. Nanofluid transport in a living soft microtube

    International Nuclear Information System (INIS)

    The mechanism of hydrodynamic transport of nanoparticles in living tissues by intrinsic lymphatic pumping remains one of the fundamental questions in the field of nanomedicine. However, despite its importance, direct visualization of the nanofluid transport mechanism has not been achieved. In this article, we report a novel in situ fluorescence bioimaging method for observing real-time microflow patterns of nanofluids confined in a contracting and expanding soft microtube. This method allows for physiological monitoring of spatiotemporally resolved microfluidic behaviour and channel undulation during the peristaltic transport of fluorescent nanoparticle suspensions by lymph vessels embedded in bulky tissues at the location of the hindlimb. The fluorescent nanofluid conferred a high optical contrast for the visualization of the lymphatic microtube, with which the concentration and viscosity of the nanofluid could be determined. The nanofluid and microtube mechanics of the hindlimb lymph vessels exhibited similar behaviours as the previously described base fluid flow of peristaltic mesenteric lymph vessels. Specifically, the microtube contraction and expansion induced increased forward flows, and a reverse flow developed at the maximum contraction, all of which corresponded to Poiseuille flow and implied that higher tube wall shear stress was related to increased axial flow velocity. On the other hand, our study identified a highly heterogeneous flow pattern that could appear during the microtube expansion phase, whose axial velocity profile remarkably deviated from the Hagen–Poiseuille equation. In addition, the peristaltic pumping power was estimated to be on the nanowatt order of magnitude. Finally, we discuss the possible applications of this nanofluidic model system in the context of nanobiotechnology. (paper)

  8. Uterine contractions evaluated on cine MR imaging in patients with uterine leiomyomas

    International Nuclear Information System (INIS)

    Purpose: Submucosal leiomyoma is one of the most recognized causes of infertility and habitual abortion. The purpose of this study is to evaluate uterine peristalsis, a cycle-related inherent contractility of uterus probably responsible for sperm transport and conservation of pregnancy, in patients with uterine leiomyomas using cine magnetic resonance (MR) imaging. Materials and methods: Study population consisted of 26 female patients (age range: 19-51 years, mean: 41 years), in which 16 patients had submucosal leiomyomas and 10 patients had intramural or subserosal leiomyomas. We prospectively performed MR imaging of the midsagittal plane of uterus using 1.5 T magnet (Symphony, Siemens Medical Systems) with a body array coil, and obtained 60 half-Fourier acquisition single shot turbo spin echo (HASTE) images (Echo time=80 ms, FOV=300 mm, slice thickness 5 mm, matrix 256x256) within 2 min, and displayed them on cine mode at 12x faster than real speed. Evaluated were peristaltic movements at the endometral-myometrial junction and focal myometrial movements, adjacent to leiomyomas, regarding presence, direction, frequency, and conduction. Results: The peristaltic movements were identified in 12/16 patients with submucosal lesions and 10/10 with other leiomyomas. The frequency and direction were cycle-related. Loss of peristalsis was noted adjacent to submucosal myomas in 4/12 patients, but was not in others. Focal myometrial movements were noted in 9/16 patients with submucosal myomas, but not in others. Conclusions: Uterine peristaltic movements were partly interrupted by submucosal leiomoymas, but not by myometrial or subserosal leiomyomas. Loss of peristalsis and focal myometrial movements was noted only adjacent to submucosal leiomyomas. These findings are considered to represent dysfunctional contractility, and may be related with pregnancy loss

  9. Nanofluid transport in a living soft microtube

    Science.gov (United States)

    Sung, Baeckkyoung; Kim, Se Hoon; Lee, Sungwoo; Lim, Jaekwan; Lee, Jin-Kyu; Soh, Kwang-Sup

    2015-09-01

    The mechanism of hydrodynamic transport of nanoparticles in living tissues by intrinsic lymphatic pumping remains one of the fundamental questions in the field of nanomedicine. However, despite its importance, direct visualization of the nanofluid transport mechanism has not been achieved. In this article, we report a novel in situ fluorescence bioimaging method for observing real-time microflow patterns of nanofluids confined in a contracting and expanding soft microtube. This method allows for physiological monitoring of spatiotemporally resolved microfluidic behaviour and channel undulation during the peristaltic transport of fluorescent nanoparticle suspensions by lymph vessels embedded in bulky tissues at the location of the hindlimb. The fluorescent nanofluid conferred a high optical contrast for the visualization of the lymphatic microtube, with which the concentration and viscosity of the nanofluid could be determined. The nanofluid and microtube mechanics of the hindlimb lymph vessels exhibited similar behaviours as the previously described base fluid flow of peristaltic mesenteric lymph vessels. Specifically, the microtube contraction and expansion induced increased forward flows, and a reverse flow developed at the maximum contraction, all of which corresponded to Poiseuille flow and implied that higher tube wall shear stress was related to increased axial flow velocity. On the other hand, our study identified a highly heterogeneous flow pattern that could appear during the microtube expansion phase, whose axial velocity profile remarkably deviated from the Hagen-Poiseuille equation. In addition, the peristaltic pumping power was estimated to be on the nanowatt order of magnitude. Finally, we discuss the possible applications of this nanofluidic model system in the context of nanobiotechnology.

  10. Uterine contractions evaluated on cine MR imaging in patients with uterine leiomyomas

    Energy Technology Data Exchange (ETDEWEB)

    Nishino, Mizuki E-mail: mizuki@mbox.kyoto-inet.or.jpnishinomizuki@hotmail.com; Togashi, Kaori; Nakai, Asako; Hayakawa, Katsumi; Kanao, Shotarou; Iwasaku, Kazuhiro; Fujii, Shingo

    2005-01-01

    Purpose: Submucosal leiomyoma is one of the most recognized causes of infertility and habitual abortion. The purpose of this study is to evaluate uterine peristalsis, a cycle-related inherent contractility of uterus probably responsible for sperm transport and conservation of pregnancy, in patients with uterine leiomyomas using cine magnetic resonance (MR) imaging. Materials and methods: Study population consisted of 26 female patients (age range: 19-51 years, mean: 41 years), in which 16 patients had submucosal leiomyomas and 10 patients had intramural or subserosal leiomyomas. We prospectively performed MR imaging of the midsagittal plane of uterus using 1.5 T magnet (Symphony, Siemens Medical Systems) with a body array coil, and obtained 60 half-Fourier acquisition single shot turbo spin echo (HASTE) images (Echo time=80 ms, FOV=300 mm, slice thickness 5 mm, matrix 256x256) within 2 min, and displayed them on cine mode at 12x faster than real speed. Evaluated were peristaltic movements at the endometral-myometrial junction and focal myometrial movements, adjacent to leiomyomas, regarding presence, direction, frequency, and conduction. Results: The peristaltic movements were identified in 12/16 patients with submucosal lesions and 10/10 with other leiomyomas. The frequency and direction were cycle-related. Loss of peristalsis was noted adjacent to submucosal myomas in 4/12 patients, but was not in others. Focal myometrial movements were noted in 9/16 patients with submucosal myomas, but not in others. Conclusions: Uterine peristaltic movements were partly interrupted by submucosal leiomoymas, but not by myometrial or subserosal leiomyomas. Loss of peristalsis and focal myometrial movements was noted only adjacent to submucosal leiomyomas. These findings are considered to represent dysfunctional contractility, and may be related with pregnancy loss.

  11. Homogeneous-heterogeneous reaction effects in peristalsis through curved geometry

    Science.gov (United States)

    Hayat, Tasawar; Tanveer, Anum; Alsaadi, Fuad; Alotaibi, Naif D.

    2015-06-01

    This paper looks at the influence of homogeneous-heterogeneous reactions on the peristaltic transport of non-Newtonian fluid in a curved channel with wall properties. Constitutive relations for thermodynamic third grade material are utilized in the problem development. An electrically conducting fluid in the presence of radial applied magnetic field is considered. The governing flow equations are developed in the presence of viscous heating. Mathematical computations are simplified employing long wavelength and low Reynolds number considerations. The solutions for velocity, temperature, concentration and heat transfer coefficient are obtained and examined. The features of sundry parameters are analyzed by plotting graphs.

  12. Homogeneous-heterogeneous reaction effects in peristalsis through curved geometry

    Directory of Open Access Journals (Sweden)

    Tasawar Hayat

    2015-06-01

    Full Text Available This paper looks at the influence of homogeneous-heterogeneous reactions on the peristaltic transport of non-Newtonian fluid in a curved channel with wall properties. Constitutive relations for thermodynamic third grade material are utilized in the problem development. An electrically conducting fluid in the presence of radial applied magnetic field is considered. The governing flow equations are developed in the presence of viscous heating. Mathematical computations are simplified employing long wavelength and low Reynolds number considerations. The solutions for velocity, temperature, concentration and heat transfer coefficient are obtained and examined. The features of sundry parameters are analyzed by plotting graphs.

  13. Homogeneous-heterogeneous reaction effects in peristalsis through curved geometry

    Energy Technology Data Exchange (ETDEWEB)

    Hayat, Tasawar [Department of Mathematics, Quaid-I-Azam University 45320, Islamabad 44000 (Pakistan); Department of Electrical and Computer Engineering, Faculty of Engineering, King Abdulaziz University, Jeddah 21589 (Saudi Arabia); Tanveer, Anum, E-mail: qau14@yahoo.com; Alsaadi, Fuad [Department of Mathematics, Quaid-I-Azam University 45320, Islamabad 44000 (Pakistan); Alotaibi, Naif D. [Department of Electrical and Computer Engineering, Faculty of Engineering, King Abdulaziz University, Jeddah 21589 (Saudi Arabia)

    2015-06-15

    This paper looks at the influence of homogeneous-heterogeneous reactions on the peristaltic transport of non-Newtonian fluid in a curved channel with wall properties. Constitutive relations for thermodynamic third grade material are utilized in the problem development. An electrically conducting fluid in the presence of radial applied magnetic field is considered. The governing flow equations are developed in the presence of viscous heating. Mathematical computations are simplified employing long wavelength and low Reynolds number considerations. The solutions for velocity, temperature, concentration and heat transfer coefficient are obtained and examined. The features of sundry parameters are analyzed by plotting graphs.

  14. Mixed convection flow of nanofluid in presence of an inclined magnetic field.

    Directory of Open Access Journals (Sweden)

    Saima Noreen

    Full Text Available This research is concerned with the mixed convection peristaltic flow of nanofluid in an inclined asymmetric channel. The fluid is conducting in the presence of inclined magnetic field. The governing equations are modelled. Mathematical formulation is completed through long wavelength and low Reynolds number approach. Numerical solution to the nonlinear analysis is made by shooting technique. Attention is mainly focused to the effects of Brownian motion and thermophoretic diffusion of nanoparticle. Results for velocity, temperature, concentration, pumping and trapping are obtained and analyzed in detail.

  15. On-line monitoring of Glucose and penicillin by sequential injection analysis

    DEFF Research Database (Denmark)

    Min, R.W.; Nielsen, Jens Bredal; Villadsen, John

    1996-01-01

    A sequential injection analysis (SIA) system has been developed for on-line monitoring of glucose and penicillin during cultivations of the filamentous fungus Penicillium chrysogenum. The SIA system consists of a peristaltic pump, an injection valve, two piston pumps, two multi-position valves and...... a detector. The glucose analyzer is based on an enzymatic reaction using glucose oxidase, which converts glucose to glucono-lactone with formation of hydrogen peroxide and subsequent detection of H2O2 by a chemiluminescence reaction involving luminol. The penicillin analysis is based on formation of...

  16. Technique for injection into the sciatic nerve of the mouse for quantitative in vivo metabolic studies

    International Nuclear Information System (INIS)

    In this paper we describe a technique for intraneural injections, applicable to mouse peripheral nerves, which, compared with previous techniques, reduces trauma to the nerves and increases the level and reduces the variability of label recovery. Our technique employs glass needles (tip diameter, 50 micron) linked to a peristaltic pump by polyethylene tubing to inject small volumes (in the microliter range) of radiolabeled substrate solutions into mouse sciatic nerves, and allows the recovery of 20.9 +/- 1.9% (mean +/- standard deviation) and 30.5 +/- 4.8% of the injected radioactivity for 2 microliter [3H]acetate and 0.5 microliter of [3H]stearate, respectively

  17. Role of cineoesophageal scintigraphy in primary and secondary oesophageal motility disorders. About a 12000 radionuclide transit study experience; Place de la cine-oesophagoscintigraphie dans les troubles moteurs oesophagiens primitifs et secondaires. A propos de 12000 explorations

    Energy Technology Data Exchange (ETDEWEB)

    Guillet, J.; Role, C.; Imbert, Y.

    1996-12-31

    Cineoesophageal scintigraphy (COS) and evaluation of oesophageal motility disorders. A 12 000 COS experience with {sup 99m}TC-sulfur colloid radiolabeled liquids is detailed. Functional qualitative and quantitative isotopic imaging parameters describe the propulsion abnormalities: mainly achalasia, diffuse esophageal spasm, nutcracker esophagus, non-specific motor disorders, systemic sclerosis, diabetes. Respective advantages and drawbacks of manometry and scintigraphy are discussed. Manometry only can measure pressures, scintigraphy only can measure bolus propulsion by peristaltic waves. Physiological and comfortable conditions, sensitivity, quantitative functional imaging, evidence of lung aspiration when swallowing advantage. (authors). 117 refs., 14 figs., 3 tabs.

  18. Role of cineoesophageal scintigraphy in primary and secondary oesophageal motility disorders. About a 12000 radionuclide transit study experience

    International Nuclear Information System (INIS)

    Cineoesophageal scintigraphy (COS) and evaluation of oesophageal motility disorders. A 12 000 COS experience with 99mTC-sulfur colloid radiolabeled liquids is detailed. Functional qualitative and quantitative isotopic imaging parameters describe the propulsion abnormalities: mainly achalasia, diffuse esophageal spasm, nutcracker esophagus, non-specific motor disorders, systemic sclerosis, diabetes. Respective advantages and drawbacks of manometry and scintigraphy are discussed. Manometry only can measure pressures, scintigraphy only can measure bolus propulsion by peristaltic waves. Physiological and comfortable conditions, sensitivity, quantitative functional imaging, evidence of lung aspiration when swallowing advantage. (authors). 117 refs., 14 figs., 3 tabs

  19. Polychlorinated biphenyls (PCB) analysis report for solid sample from 219S tank 101

    Energy Technology Data Exchange (ETDEWEB)

    Diaz, L.A.

    1998-02-04

    One waste sample that was obtained with solids from tank 101 of 219S via a peristaltic pump equipped with a stainless steel tube and Norprene tubing (Phthalate free) was obtained in a glass jar with teflon lid was analyzed (with duplicate, matrix spike, and matrix spike duplicate) for PCBs as Aroclor mixtures by the Inorganic/Organic Chemistry Group. A soxhlet extraction procedure was used for extraction of the Aroclors from the sample. Analysis was performed using dual column confirmation gas chromatography/electron capture detection (GC/ECD). Results are presented.

  20. Modelling and simulation of diffusive processes methods and applications

    CERN Document Server

    Basu, SK

    2014-01-01

    This book addresses the key issues in the modeling and simulation of diffusive processes from a wide spectrum of different applications across a broad range of disciplines. Features: discusses diffusion and molecular transport in living cells and suspended sediment in open channels; examines the modeling of peristaltic transport of nanofluids, and isotachophoretic separation of ionic samples in microfluidics; reviews thermal characterization of non-homogeneous media and scale-dependent porous dispersion resulting from velocity fluctuations; describes the modeling of nitrogen fate and transport

  1. Homogeneous-heterogeneous reaction effects in peristalsis through curved geometry

    International Nuclear Information System (INIS)

    This paper looks at the influence of homogeneous-heterogeneous reactions on the peristaltic transport of non-Newtonian fluid in a curved channel with wall properties. Constitutive relations for thermodynamic third grade material are utilized in the problem development. An electrically conducting fluid in the presence of radial applied magnetic field is considered. The governing flow equations are developed in the presence of viscous heating. Mathematical computations are simplified employing long wavelength and low Reynolds number considerations. The solutions for velocity, temperature, concentration and heat transfer coefficient are obtained and examined. The features of sundry parameters are analyzed by plotting graphs

  2. Complex radioisotopic examination of renal functions using SOPHA MEDICAL program system

    International Nuclear Information System (INIS)

    Repeated isotopic scanning of the kidneys were made on a patient with complex renal diseases, on two consecutive days, in sitting and in lying position, resp. The scanning was done with 99mTc-MAG3 administered intravenously to the patient, starting computer scanning of gamma camera frames simultaneously. The data were evaluated by the SOPHA MEDICAL software of Sopha Medical GmbH, Frankfurt, Germany. It was observed that, in sitting position, the kidney perfusion, the early uptake, the tubular clearance and the ureter peristaltic are disturbed because of the compression of renal artery and ureter. These functions were recovered in the lying position. (R.P.) 14 refs.; 8 figs

  3. Polychlorinated biphenyls (PCB) analysis report for solid sample from 219S tank 101

    International Nuclear Information System (INIS)

    One waste sample that was obtained with solids from tank 101 of 219S via a peristaltic pump equipped with a stainless steel tube and Norprene tubing (Phthalate free) was obtained in a glass jar with teflon lid was analyzed (with duplicate, matrix spike, and matrix spike duplicate) for PCBs as Aroclor mixtures by the Inorganic/Organic Chemistry Group. A soxhlet extraction procedure was used for extraction of the Aroclors from the sample. Analysis was performed using dual column confirmation gas chromatography/electron capture detection (GC/ECD). Results are presented

  4. Space Station Environmental Control and Life Support System Purge Control Pump Assembly Modeling and Analysis

    Science.gov (United States)

    Schunk, R. Gregory; Hunt, Patrick L. (Technical Monitor)

    2001-01-01

    Preliminary results from a thermal/flow analysis of the Purge Control Pump Assembly (PCPA) indicate that pump performance (mass flow rate) is enhanced via cooling of the housing and lowering of the inlet vapor quality. Under a nominal operational profile (25% duty cycle or less), at the maximum motor dissipation, it appears that the peristaltic tubing temperature will still remain significantly below the expected UPA condenser temperature (78 F max versus approximately 105 F in the condenser) permitting condensation in the pump head.

  5. The Application of Flow Injection Technology to Automating Cold Vapor Mercury Analyses in Aquatic Ecosystems

    Directory of Open Access Journals (Sweden)

    TEODOROF, L.

    2009-02-01

    Full Text Available Based on flow injection techniques, FIMS is fully automated, fast, and cost-effective. The FIMS uses a high-performance single-beam optical system with a low pressure mercury lamp and solar-blind detector for maximum performance. The FIMS-400 has two stepper motor-driven peristaltic pumps for greater flexibility when used with optional accessories. FIMS is fully controlled from a personal computer using WinLab32 for AA software, a true Microsoft Windows-based program with an unparalleled offering of standard features, including a full range of analytical checks and quality control functions.

  6. Oesophageal food impaction in achalasia treated with Coca-Cola and nifedipine.

    Science.gov (United States)

    Koumi, Andriani; Panos, Marios Zenon

    2010-01-01

    Achalasia is characterised by the loss of peristaltic movement in the distal oesophagus and failure of the lower oesophageal sphincter relaxation, which results in impaired oesophageal emptying. We report a case of a 92-year-old frail woman with a history of achalasia, who presented with acute oesophageal obstruction due to impaction of a large amount of food material. She was treated successfully with nifedipine, in combination with Coca-Cola (original product, not sugar free), so avoiding the risks associated with repeated endoscopic intubation and piecemeal removal of the oesophageal content. PMID:22242073

  7. Computed tomography studies of human brain movements

    International Nuclear Information System (INIS)

    Rhythmic brain movements have been revealed by sets of sequential computed tomography scans of human brains (seen retrospectively to be normal). These scans have shown that both (unenhanced) brain parenchymal density and the shapes of the elements of the supratentorial ventricular/cisternal system are subject to wave motions having similar periods - ranging from 26 s through 56 s, 77-96 s, 109 s and 224 s to 224 X 2 s (or even longer), with good correlation between peak values. These motions, as well as phase variations between the waves, suggest a peristaltic movement of cerebrospinal fluid through the ventricular/cisternal system with progressive axial damping

  8. Slow rhythmic ventricular oscillations and parenchymal density variations shown by sequential CT scanning

    International Nuclear Information System (INIS)

    Rhythmic brain movements have been revealed by sets of sequential computerised tomography scans of human brains (seen retrospectively to be normal). These scans have shown that both (unenhanced) brain parenchymal density and the shapes of the elements of the supratentorial ventricular/cisternal system are subject to wave motions having similar periods-ranging from 26 s through 56 s, 77-96 s, 109 s, and 224 s to 224 x 2 s (or even longer), with good correlation between peak values. These motions, as well as phase variations between the waves suggest a peristaltic movement of CSF through the ventricular/cisternal system with progressive axial damping

  9. The MainSTREAM Component Platform: A Holistic Approach to Microfluidic System Design

    DEFF Research Database (Denmark)

    Sabourin, David; Skafte-Pedersen, Peder; Søe, Martin Jensen;

    2013-01-01

    A microfluidic component library for building systems driving parallel or serial microfluidic-based assays is presented. The components are a miniaturized eight-channel peristaltic pump, an eight-channel valve, sample-to-waste liquid management, and interconnections. The library of components was...... reaction chips; (2) highly parallel pumping and routing/valving capability; (3) methods to interface pumps and chip-to-liquid management systems; (4) means to construct a portable system; (5) reconfigurability/flexibility in system design; (6) means to interface to microscopes; and (7) compatibility with...

  10. Bioengineering fluid mechanics

    CERN Document Server

    Hung, Tin-kan

    2013-01-01

    This book highlights the basic concepts and equations for bioengineering flow processes. Physical concepts and meanings are emphasized while rigorous derivations are simplified, making it easier for self learning on some biological and medical flow processes. The well known Bernoulli equation in hydraulics is extended for pulsating flows, peristaltic flows and cardiac pumping. The dimensional analysis, model law and dimensionless equations can be related to computational models and experimental observations. The velocity vector imaging stored in echocardiograms can be used to analyze the pumping characteristics of the ventricular contraction. New topics included oxygen transport in membrane oxygenator and micro mixing of blood flow in capillary channels.

  11. Backflushing Filters for Field Processing of Water Samples Prior to Trace-Element Analyses

    Science.gov (United States)

    Kennedy, V.C.; Jenne, E.A.; Burchard, J.M.

    1976-01-01

    A portable unit is described for filtering water samples at field sites in such a manner that the filtrate is suitable for analysis not only of major constituents but also of trace elments at the mocrogram-per-liter level. A battery-operated peristaltic pump forces the water sample through medical-grade silicone tubing into and through an all-plastic in-line filter which can be backflushed when sediment clogs the filter membrane. Initial filtration rate exceeds 500 milliliter/minute and, because of the backflushing feature, a total time for filtering high-sediment-bearing waster samples is greatly reduced. (Woodard-USGS)

  12. Silicon micromachined pumps employing piezoelectric membrane actuation for microfluidic systems

    Science.gov (United States)

    Koch, Michael

    Microsystems technology is a rapidly expanding area that comprises electronics, mechanics and optics. In this field, physical/chemical sensing, fluid handling and optical communication are emerging as potential markets. Microfluidic systems like an implantable insulin pump, a drug delivery system and a total chemical analysis system are currently being developed by academia and industry around the world. This project contributes to the area of microfluidics in that a novel thick-film-on-silicon membrane actuator has been developed to allow inexpensive mass production of micropumps. To date piezoelectric plates have been surface mounted onto a silicon membrane. This single chip fabrication method can now be replaced by screen printing thick piezoelectric layers onto 4 inch silicon substrates. Two different pump types have been developed. These are membrane pumps with either cantilever valves or diffuser/nozzle valves. Pump rates between 100 and 200 μl min-1 and backpressures up to 4 kPa have been achieved with these pumps. Along with the technology of micropumps, simulators have been developed. A novel coupled FEM-CFD solver was realised by a computer controlled coupling of two commercially available packages (ANSYS and CFX-Flow3D). The results of this simulator were in good agreement with measurements on micromachined cantilever valves. CFX- Flow3D was also used to successfully model the behaviour of the diffuser/nozzle valve. Finally, the pump has been simulated using a continuity equation. A behavioural dynamic extension of the cantilever valve was necessary to achieve better prediction of the pump rates for higher frequencies. As well, a common process has been developed for microfluidic devices like micromixers, particle counters and sorters as well as flow sensors. The micromixer has been tested already and achieves mixing for input pressures between 2 and 7 kPa. This agrees with simulations of the diffusive mixing with CFX-Flow3D. Together with the micropump

  13. Performances analysis of a piezo-pump

    Directory of Open Access Journals (Sweden)

    Belkhiat S.

    2012-06-01

    Full Text Available Piezo-pumps, in the last decade, have received extensive attention because of their potential applications in biomedical devices, biological and chemical analysis, micro-electronics cooling and space exploration. In this paper an analytical model is developed to analysis the parameters effect on the pump flow. The micro-pump driven by piezostack (PZT alloy multilayer as actuator is studied as function size and working middle. This one is compared with SCMCP pump actuated by PZT alloy as piezomembrane. The flow change as a function frequency, the chamber diameter and control voltage are analyzed. The simulation results obtained with two different liquids (water and blood as working middle are discussed and compared with experimental results. The results are satisfactory.

  14. Pumping by flapping in a viscoelastic fluid

    CERN Document Server

    Pak, On Shun

    2010-01-01

    In a world without inertia, Purcell's scallop theorem states that in a Newtonian fluid a time-reversible motion cannot produce any net force or net flow. Here we consider the extent to which the nonlinear rheological behavior of viscoelastic fluids can be exploited to break the constraints of the scallop theorem in the context of fluid pumping. By building on previous work focusing on force generation, we consider a simple, biologically-inspired geometrical example of a flapper in a polymeric (Oldroyd-B) fluid, and calculate asymptotically the time-average net fluid flow produced by the reciprocal flapping motion. The net flow occurs at fourth order in the flapping amplitude, and suggests the possibility of transporting polymeric fluids using reciprocal motion in simple geometries even in the absence of inertia. The induced flow field and pumping performance are characterized and optimized analytically. Our results may be useful in the design of micro-pumps handling complex fluids.

  15. Photothermal generation of microbubbles on plasmonic nanostructures inside microfluidic channels

    Science.gov (United States)

    Li, Jingting; Li, Ming; Santos, Greggy M.; Zhao, Fusheng; Shih, Wei-Chuan

    2016-03-01

    Microbubbles have been utilized as micro-pumps, micro-mixers, micro-valves, micro-robots and surface cleaners. Various generation techniques can be found in the literature, including resistive heating, hydrodynamic methods, illuminating patterned metal films and noble metal nanoparticles of Au or Ag. We present photothermal microbubble generation by irradiating nanoporous gold disk covered microfluidic channels. The size of the microbubble can be controlled by adjusting the laser power. The dynamics of both bubble growth and shrinkage are studied. The advantages of this technique are flexible bubble generation locations, long bubble lifetimes, no need for light-adsorbing dyes, high controllability over bubble size, low power consumption, etc. This technique has the potential to provide new flow control functions in microfluidic devices.

  16. Biomedical monitoring of phosphate removal by hemodialysis.

    Science.gov (United States)

    Michalec, Michał; Fiedoruk-Pogrebniak, Marta; Matuszkiewicz-Rowińska, Joanna; Tymecki, Łukasz; Koncki, Robert

    2016-07-15

    A compact flow analysis system for non-invasive, dialysate-side monitoring of phosphate removal in the course of clinical hemodialysis treatment is presented. The monitor is based on solenoid operated micro-pumps and extremely cheap optoelectronic flow-through detector allowing photometric determination of phosphate in spent dialysate using a molybdenum blue method. The monitor can operate in both, discrete and continuous modes of measurement. The analytical utility of monitor has been tested with samples of spent dialysate produced by artificial kidney in the course of real hemodialysis sessions. The results of monitoring are comparable with those obtained using reference off-line method recommended for clinical analysis. Additionally, the possibility of two-side (dialysate and blood) monitoring of hemodialysis treatments with optoelectronic flow-through detectors has been announced. PMID:27136282

  17. Nursing care of indwelling catheter thrombolysis for acute thrombosis in the arteriovenous fistula in hemodialysis patients

    International Nuclear Information System (INIS)

    Objective: To summarize the experience of the nursing care of indwelling catheter thrombolysis for acute thrombosis in the arteriovenous fistula in eight hemodialysis patients. Methods: After breaking thrombus through indwelling catheter, both bolus injection and micro-pump continuous infusion of urokinase was employed in eight hemodialysis patients with acute thrombosis in the arteriovenous fistula. The necessary nursing measures were carried out to assist the whole therapeutic procedure. Results: All the patients could well cooperate with the procedure of indwelling catheter thrombolysis and urokinase infusion. The reopening rate of the obstructed fistula was 100%. Conclusion: Indwelling catheter thrombolysis with urokinase infusion is a simple, effective and safe treatment for acute thrombosis in the arteriovenous fistula in hemodialysis patients. In order to obtain optimal results, necessary nursing measures must be carried out. (authors)

  18. Mechanical Stress Downregulates MHC Class I Expression on Human Cancer Cell Membrane

    DEFF Research Database (Denmark)

    La Rocca, Rosanna; Tallerico, Rossana; Hassan, Almosawy Talib;

    2014-01-01

    treated either with mechanical stress delivered by a micropump (fabricated by deep X-ray nanolithography) or by ultrasound wave stimuli. A specific down-regulation of Major Histocompatibility Complex (MHC) class I molecules expression on cancer cell membrane compared to different kinds of healthy cells......In our body, cells are continuously exposed to physical forces that can regulate different cell functions such as cell proliferation, differentiation and death. In this work, we employed two different strategies to mechanically stress cancer cells. The cancer and healthy cell populations were...... (fibroblasts, macrophages, dendritic and lymphocyte cells) was observed, stimulating the cells with forces in the range of nano-newton, and pressures between 1 and 10 bar (1 bar5100.000 Pascal), depending on the devices used. Moreover, Raman spectroscopy analysis, after mechanical treatment, in the range...

  19. SmartBuild-a truly plug-n-play modular microfluidic system.

    Science.gov (United States)

    Yuen, Po Ki

    2008-08-01

    In this Technical Note, for the first time, a truly "plug-n-play" modular microfluidic system (SmartBuild Plug-n-Play Modular Microfluidic System) is presented for designing and building integrated modular microfluidic systems for biological and chemical applications. The modular microfluidic system can be built by connecting multiple microfluidic components together to form a larger integrated system. The SmartBuild System comprises of a motherboard with interconnect channels/grooves, fitting components, microchannel inserts with different configurations and microchips/modules with different functionalities. Also, heaters, micropumps and valving systems can be designed and used in the system. Examples of an integrated mixing system and reaction systems are presented here to demonstrate the versatility of the SmartBuild System. PMID:18651081

  20. Rarefaction effects in microchannel gas flow driven by rhythmic wall contractions

    Science.gov (United States)

    Chatterjee, Krishnashis; Staples, Anne; Department of Biomedical Engineering; Mechanics, Virginia Tech Collaboration

    2015-11-01

    Current state of the art microfluidic devices employ precise and timely operation of a complex arrangement of micropumps and valves for fluid transport. A much more novel flow transport mechanism is found in entomological respiratory systems, which involve rhythmic wall contractions for driving the fluid flow. The practical viability of using this technique in future microfluidic devices has been studied earlier. The present study investigates the incorporation of rarefaction effects in the above model of microscale gas flow by including slip boundary conditions. The Navier Stokes equations for gas flow in rectangular microchannel are solved analytically with microscale and lubrication theory assumptions. First order slip boundary conditions are incorporated to account for the rarefaction effects. The dependence of fluid velocities and pressure gradient on the slip boundary conditions is studied. Time averaged unidirectional fluid flow rates are plotted for different phase lags between the contractions, with and without slip in order to obtain an optimum range under different conditions.

  1. Design of Fault-Tolerant and Dynamically-Reconfigurable Microfluidic Biochips

    CERN Document Server

    Su, Fei

    2011-01-01

    Microfluidics-based biochips are soon expected to revolutionize clinical diagnosis, DNA sequencing, and other laboratory procedures involving molecular biology. Most microfluidic biochips are based on the principle of continuous fluid flow and they rely on permanently-etched microchannels, micropumps, and microvalves. We focus here on the automated design of "digital" droplet-based microfluidic biochips. In contrast to continuous-flow systems, digital microfluidics offers dynamic reconfigurability; groups of cells in a microfluidics array can be reconfigured to change their functionality during the concurrent execution of a set of bioassays. We present a simulated annealing-based technique for module placement in such biochips. The placement procedure not only addresses chip area, but it also considers fault tolerance, which allows a microfluidic module to be relocated elsewhere in the system when a single cell is detected to be faulty. Simulation results are presented for a case study involving the polymeras...

  2. Microfluidic in-channel multi-electrode platform for neurotransmitter sensing

    Science.gov (United States)

    Kara, A.; Mathault, J.; Reitz, A.; Boisvert, M.; Tessier, F.; Greener, J.; Miled, A.

    2016-03-01

    In this project we present a microfluidic platform with in-channel micro-electrodes for in situ screening of bio/chemical samples through a lab-on-chip system. We used a novel method to incorporate electrochemical sensors array (16x20) connected to a PCB, which opens the way for imaging applications. A 200 μm height microfluidic channel was bonded to electrochemical sensors. The micro-channel contains 3 inlets used to introduce phosphate buffer saline (PBS), ferrocynide and neurotransmitters. The flow rate was controlled through automated micro-pumps. A multiplexer was used to scan electrodes and perform individual cyclic voltammograms by a custom potentiostat. The behavior of the system was linear in terms of variation of current versus concentration. It was used to detect the neurotransmitters serotonin, dopamine and glutamate.

  3. Clinical microdialysis in neuro-oncology: principles and applications

    Institute of Scientific and Technical Information of China (English)

    J. Clay Goodman

    2011-01-01

    Clinical microdialysis allows a discrete volume of the brain to be sampled for neurochemical analysis of neurotransmitters, metabolites, biomarkers, and drugs. The technique can be safely used in humans intraoperatively, in the intensive care unit, and in ambulatory settings. Microdialysis probes, micropumps, and analytical equipment are commercially available and have been used extensively for neurochemical monitoring in traumatic brain injury, stroke, and subarachnoid hemorrhage. There has been very limited use of micredialysis in neuro-oncology, but this technique has groat promise in the study of the basic neurochemistry of brain tumors, alterations in neurochemistry in response to therapy, and the pharmacokinetics of chemotherapeutic agents. Microdialysis probes may also be used to deliver drugs while simultaneously permitting monitoring of neurochemical changes induced by this therapy.

  4. Fully Automated Quantification of Insulin Concentration Using a Microfluidic-Based Chemiluminescence Immunoassay.

    Science.gov (United States)

    Yao, Ping; Liu, Zhu; Tung, Steve; Dong, Zaili; Liu, Lianqing

    2016-06-01

    A fully automated microfluidic-based detection system for the rapid determination of insulin concentration through a chemiluminescence immunoassay has been developed. The microfluidic chip used in the system is a double-layered polydimethylsiloxane device embedded with interconnecting micropumps, microvalves, and a micromixer. At a high injection rate of the developing solution, the chemiluminescence signal can be excited and measured within a short period of time. The integral value of the chemiluminescence light signal is used to determine the insulin concentration of the samples, and the results indicate that the measurement is accurate in the range from 1.5 pM to 391 pM. The entire chemiluminescence assay can be completed in less than 10 min. The fully automated microfluidic-based insulin detection system provides a useful platform for rapid determination of insulin in clinical diagnostics for diabetes, which is expected to become increasingly important for future point-of-care applications. PMID:25824205

  5. Osmotically driven flows in microchannels separated by a semipermeable membrane

    Science.gov (United States)

    Bruus, Henrik; Hartvig Jensen, Kaare; Bohr, Tomas

    2008-11-01

    Osmotically driven flows in microchannels are studied experimentally and theoretically. The propagation of the front of sugar solutions has been measured using dye and particle tracking in 200 μm wide and 50, 100, and 200 μm high polymer-based microchannels. Each of these microchannels was separated by a semipermeable membrane from a reservoir containing pure water. We have also established a theoretical model of this system. In the limit of low axial flow resistance, our model predicts the propagation speed of the sugar front as a function of sugar concentration and channel geometry. The theoretical predictions agree well with the measurements. Our motivations for studying osmotically driven flows are that they are believed to be responsible for the translocation of sugar in plants and that they can be used as the driving mechanism in micropumps with no moveable parts.[5mm] This work was supported by the Danish National Research Foundation, Grant No. 74.

  6. Observations and temporal model of a honeybee's hairy tongue in microfluid transport

    Science.gov (United States)

    Zhao, Chenjia; Wu, Jianing; Yan, Shaoze

    2015-11-01

    Nectarivorous insects are endowed with specific mouthparts, which provide an inspiration for the design of micropumps. We combined the postmortem examination and high-speed imaging to observe the kinematics of the honeybee's tongue. We found an asynchronization between the tongue movement and the glossa hair erection. We propose a physical model to describe the feeding process considering the trade-off between nectar-intake volume and energy consumption. This asynchronization is validated to be effective in maximizing the nectar-intake amount by theoretically figuring out the optimal moment when the glossal hairs began to erect. Our results reveal that the honeybee not only develops a subtle tongue with erectable glossal hairs but also preforms a highly evolved scheduled coordination between tongue movements and hair erection, which could serve as valuable models for developing miniature pumps that are both extendable and have dynamic surfaces.

  7. Silicon Micromachining

    Science.gov (United States)

    Elwenspoek, Miko; Jansen, Henri V.

    2004-08-01

    This comprehensive book provides an overview of the key techniques used in the fabrication of micron-scale structures in silicon. Recent advances in these techniques have made it possible to create a new generation of microsystem devices, such as microsensors, accelerometers, micropumps, and miniature robots. The authors underpin the discussion of each technique with a brief review of the fundamental physical and chemical principles involved. They pay particular attention to methods such as isotropic and anisotropic wet chemical etching, wafer bonding, reactive ion etching, and surface micromachining. There is a special section on bulk micromachining, and the authors also discuss release mechanisms for movable microstructures. The book is a blend of detailed experimental and theoretical material, and will be of great interest to graduate students and researchers in electrical engineering and materials science whose work involves the study of micro-electromechanical systems (MEMS).

  8. Distributed Cooling in Cryogenics with Miniaturized Fluid Circuits

    CERN Document Server

    Grohmann, Steffen

    This work presents the development of miniaturized cryogenic fluid circuits for cooling of low temperature tracking detectors in High Energy Physics (HEPI. The system development comprises the circuit layout and control, and the design of major circuit components. It includes the development of a prototype cryogenic micropump compatible with cooling powers of about l0 W to l00 W, and capable of producing pressure heads of several bars. Focus is given to the design of microtube heat exchangers for direct evaporative cooling of sensors and electronic devices. Extensive experimental investigations on heat transfer in microtubes of 250 $\\mu m$ and 500 $\\mu m$ diameter are presented, carried out with argon at about 120 K. A new relative roughness parameter is introduced to model the effect of macroscopic surface roughness on convective heat transfer. An extension of the diameter function in the VDI Heat Atlas correlation for nucleate boiling in vertical tubes is proposed. Besides HEP, potential applications are es...

  9. System-Level Modeling and Synthesis of Flow-Based Microfluidic Biochips

    DEFF Research Database (Denmark)

    Minhass, Wajid Hassan; Pop, Paul; Madsen, Jan

    Microfluidic biochips are replacing the conventional biochemical analyzers and are able to integrate the necessary functions for biochemical analysis on-chip. There are several types of microfluidic biochips, each having its advantages and limitations. In this paper we are interested in flow......-based biochips, in which the flow of liquid is manipulated using integrated microvalves. By combining several microvalves, more complex units, such as micropumps, switches, mixers, and multiplexers, can be built. Although researchers have proposed significant work on the system-level synthesis of droplet......-based biochips, which manipulate droplets on a two-dimensional array of electrodes, no research on system-level synthesis of flow-based biochips has been reported so far. The focus has been on application modeling and component-level simulation. Therefore, for the first time to our knowledge, we propose a system...

  10. Buckling instability of thin films as a means to control or enhance fluid flow within microchannel

    Science.gov (United States)

    Tavakol, Behrouz; Chawan, Aschvin; Holmes, Douglas

    2014-11-01

    Here we show that the buckling of thin, flexible plates can be used for pumping fluids, controlling the flow rate, and mixing different media within a microfluidic channel. A confined, dielectric elastomeric film buckles out of the plane when exposed to an electric field. We use an electrolytic fluid solution as the electrode to enable buckling at relatively low voltages, and to enhance the rate of deformation. When embedded in a microfluidic channel, this mechanism can be used as a microvalve that controls the flow rate, or as a micropump that alters the flow rate. A similar mechanism can be used to aid diffusion between two adjacent laminar streams and improve mixing. This novel means for dielectric actuation may improve voltage application, and the buckling microstructures may be used in variety of applications to accurately control and manipulate fluid flow in a microchannel.

  11. Pump it up

    Science.gov (United States)

    Maffli, Luc; O'Brien, Benjamin; Rosset, Samuel; Shea, Herbert

    2012-04-01

    We report on the use of zipping actuation applied to dielectric elastomer actuators to microfabricate mm-sized pumps. The zipping actuators presented here use electrostatic attraction to deform an elastomeric membrane by pulling it into contact with a rigid counter electrode. We present several actuation schemes using either conventional DEA actuation, zipping, or a combination of both in order to realize microfluidic devices. A zipping design in which the electric field is applied across the elastomer membrane was explored theoretically and experimentally. Single zipping chambers and a micropump body made of a three chambers connected by an embedded channel were wet-etched into a silicon wafer and subsequently covered by a gold-implanted silicone membrane. We measured static deflections of up to 300 μm on chambers with square openings of 1.8 and 2.6 mm side, in very good agreement with our model.

  12. Web-Based Synthetic Optimization Design System of Micro-Components

    Institute of Scientific and Technical Information of China (English)

    GONG Xiao-yan; JIANG Ping-yu

    2005-01-01

    In order to meet the requirement of network synthesis optimization design for a micro component, a three-level information frame and functional module based on web was proposed. Firstly, the finite element method (FEM) was used to analyze the dynamic property of coupled-energy-domain of virtual prototype instances and to obtain some optimal information data. Secondly, the rough set theory (RST) and the genetic algorithm (GA) were used to work out the reduction of attributes and the acquisition of principle of optimality and to confirm key variable and restriction condition in the synthesis optimization design. Finally, the regression analysis (RA) and GA were used to establish the synthesis optimization design model and carry on the optimization design. A corresponding prototype system was also developed and the synthesis optimization design of a thermal actuated micro-pump was carried out as a demonstration in this paper.

  13. 不同输注法治疗急性胰腺炎的临床效果%Effect of different phleboclysis on acute pancreatitis patients

    Institute of Scientific and Technical Information of China (English)

    张志达; 张茂; 刘春玲; 胡江; 李明章; 侯瑞生

    2010-01-01

    目的 探讨不同输入方法治疗急性胰腺炎的综合疗效.方法 110例急性胰腺炎患者随机分为传统输液组(50例)、微量泵24 h持续泵入组(30例)和微量泵12 h持续泵入组(30例).观察统计临床治疗效果、不良反应、满意度、平均住院日等.结果 泵入组与传统组比较其临床治疗效果无差异性;药物不良反应泵入组明显低于传统组(P<0.01);满意度泵入组明显高于传统组(P<0.05).12 h泵入组与24 h泵入组比较其临床治疗效果、药物不良反应均无差异性;满意度12 h泵入组高于24 h泵入组(P<0.05).三组平均住院日传统组18 d、24 h泵入组16 d、12 h泵入组12 d.结论 12 h泵入组各项指标优于其它组,住院天数缩短,减少了病人的经济负担,扩大了社会效益.%Objective To explore the effect of different phleboclysis on acute pancreatitis patients. Methods One hundred and ten acute pancreatitis patients were randomly divided into traditional infusion group, micro-pump 24 hours continuous infusion group and 12hours continuous infusion group. The therapeutic effect, adverse reactions, the degree of satisfaction, average length of stay were observed. Results ① The therapeutic effect had no significant difference between micro-pump group and traditional group ( P > 0. 05 ) .Adverse drug reaction in micro-pump groups were significantly lower than that in traditional group ( P <0. 01 ) . The degree of satisfaction in micro-pump groups were significantly higher than that in traditional group ( P < 0. 05 ) . ②The therapeutic effect and adverse drug reactions had no significant different between the 12 hours pump group and 24 hours pump group (P > 0. 05 ) . The degree of satisfaction in 12hours pump group was higher than that of 24 hours pump group (P <0. 05) . ③The average length of stay were 18 d, 16 d, 12 d in traditional group, 24 hours pump group and 12 hours pump group respectively. Conclusions 12 hours pump group

  14. Rapid chemiluminometric determination of gabapentin in pharmaceutical formulations exploiting pulsed-flow analysis.

    Science.gov (United States)

    Manera, Matías; Miró, Manuel; Ribeiro, Marta F T; Estela, José Manuel; Cerdà, Víctor; Santos, João L M; Lima, José L F C

    2009-01-01

    In this study, a straightforward and automated pulsed flow-based procedure was developed for the chemiluminometric determination of gabapentin [1-(aminomethyl)cyclo-hexaneacetic acid], a new generation antiepileptic drug, in different formulated dosage forms. The software-controlled time-based injection method capitalizes on the decrease of the background chemiluminescence (CL) readout of the luminol-hypochlorite reaction in the presence of gabapentin. In short, gabapentin works as a hypochlorite scavenger. The analytical procedure was implemented in a multi-pumping flow network furnished with a suite of microdispensing solenoid-actuated pumps. The diaphragm-type micropumps might be configured to operate as fluid propellers, commutation units and metering injectors. A dynamic linear working range for gabapentin concentrations in the range 60-350 micromol/L was obtained, with an estimated detection limit of 40 micromol/L. The flow analyser handles about 41 injections/h and yields precise results (RSD pharmaceutical companies. PMID:18780326

  15. Topology Optimisation for Coupled Convection Problems

    DEFF Research Database (Denmark)

    Alexandersen, Joe; Andreasen, Casper Schousboe; Aage, Niels;

    in the solid are [3-6]. The developed methodology is applied to several two-dimensional solid-fluid thermal interaction problems, such as cooling of electronic components and heat exchangers, as well as to the design of micropumping devices based on natural convection effects. The implementation utilises......The work focuses on applying topology optimisation to forced and natural convection problems in fluid dynamics and conjugate (fluid-structure) heat transfer. To the authors' knowledge, topology optimisation has not yet been applied to natural convection flow problems in the published literature...... and the current work is thus seen as contributing new results to the field. In the literature, most works on the topology optimisation of weakly coupled convection-diffusion problems focus on the temperature distribution of the fluid, but a selection of notable exceptions also focusing on the temperature...

  16. Solution of Two-Dimensional Viscous Flow Driven by Motion of Flexible Walls

    Directory of Open Access Journals (Sweden)

    Mohamed Gad-el-Hak

    2010-03-01

    Full Text Available An exact solution of the Navier–Stokes equations for a flow driven by motion of flexible wall is developed. A simple two-dimensional channel with deforming walls is considered as domain. The governing equations are linearized for low Reynolds number and large Womersley number Newtonian flows. Appropriate boundary conditions for general deformation are decomposed into harmonic excitations in space by Fourier series decomposition. A model of harmonic boundary deformation is considered and results are compared with computational fluid dynamics predictions. The results of velocity profiles across the channel and the centerline velocities of the channel are in good agreement with CFD solution. The analytical model developed provides quantitative descriptions of the flow field for a wide spectrum of actuating frequnecy and boundary conditions. The presented model can be used as an effective framework for preliminary design and optimization of displacement micropumps and other miniature applications.

  17. Hyperpolarised sup 3 He gas production for magnetic resonance imaging of the human air ways

    CERN Document Server

    Fichele, S

    2002-01-01

    This thesis describes the experimental techniques, and methods employed in hyperpolarised sup 3 He gas production and magnetic resonance imaging of the human air-ways, using spin-echo sequences and MR tagging techniques. An in-house polariser utilising the metastability optical pumping technique was constructed. The main results of this work are concerned with engineering difficulties involved in compressing HP sup 3 He and a large proportion of this PhD thesis details the design, construction, and performance of an in-house built peristaltic compressor. In preliminary imaging experiments using RARE, high signal to noise projection images of the lungs were acquired using less than 0.5 cm sup 3 (STP) of purely polarised HP gas. Later, increased HP gas quantities (typically 10 cm sup 3) were obtained by employing the peristaltic compressor. Consequently we could acquire 10 mm thick slices spanning the entire lung following a single sup 3 He gas bolus administration. Finally, the first results using MR tagging t...

  18. Automation of cells of radiopharmaceuticals production

    International Nuclear Information System (INIS)

    The 67Ga is an important radiopharmaceutical used to identify inflammatory processes in chronic illnesses, diagnosis by image of tumors in soft tissues and the possibility to evaluate the result for therapeutic intervention. In the present work a module of 67Ga processing was developed with the objective to reduce the interventions in the hot cell, in order to avoid oxidation caused by metallic materials, and consuming in hoses of the peristaltic pumps, that release residues that blocked the valves used in the process. With materials such as: acrylic, PVC, PEEK e teflon and they are used vacuum as method (way) of fluid transferences instead of peristaltic pump in the majority of the procedures, with this improvements the system can make shorter the lengths of transference hoses, increasing the yield in the process with less interventions for maintenance and time exposure of the workers, guaranteeing the quality and reducing the time of the processing. using a mobile system for displacement of the processing module making in the cleanness and maintenance of the cell that works with radioactive material. Reducing the time of exposure dose of the workers in compliance with RDC-17 of ANVISA, which ruling the Good Manufacturing Practice Procedures. (author)

  19. A flow-batch analyzer with piston propulsion applied to automatic preparation of calibration solutions for Mn determination in mineral waters by ET AAS.

    Science.gov (United States)

    Almeida, Luciano F; Vale, Maria G R; Dessuy, Morgana B; Silva, Márcia M; Lima, Renato S; Santos, Vagner B; Diniz, Paulo H D; Araújo, Mário C U

    2007-10-31

    The increasing development of miniaturized flow systems and the continuous monitoring of chemical processes require dramatically simplified and cheap flow schemes and instrumentation with large potential for miniaturization and consequent portability. For these purposes, the development of systems based on flow and batch technologies may be a good alternative. Flow-batch analyzers (FBA) have been successfully applied to implement analytical procedures, such as: titrations, sample pre-treatment, analyte addition and screening analysis. In spite of its favourable characteristics, the previously proposed FBA uses peristaltic pumps to propel the fluids and this kind of propulsion presents high cost and large dimension, making unfeasible its miniaturization and portability. To overcome these drawbacks, a low cost, robust, compact and non-propelled by peristaltic pump FBA is proposed. It makes use of a lab-made piston coupled to a mixing chamber and a step motor controlled by a microcomputer. The piston-propelled FBA (PFBA) was applied for automatic preparation of calibration solutions for manganese determination in mineral waters by electrothermal atomic-absorption spectrometry (ET AAS). Comparing the results obtained with two sets of calibration curves (five by manual and five by PFBA preparations), no significant statistical differences at a 95% confidence level were observed by applying the paired t-test. The standard deviation of manual and PFBA procedures were always smaller than 0.2 and 0.1mugL(-1), respectively. By using PFBA it was possible to prepare about 80 calibration solutions per hour. PMID:19073119

  20. Effect of oral contraceptives on uterine peristalsis. Evaluation with MR imaging

    International Nuclear Information System (INIS)

    The purpose of this study was to evaluate the effects of oral contraceptives (OCs) on uterine contractility using cine MR imaging. Thirty-six healthy female volunteers of reproductive age, 20 of whom were taking OCs, were evaluated at mid-cycle. MR images were acquired with a 1.5T magnet unit; 60 serial images were obtained every 3 s over 3 min by HASTE (half-Fourier acquired single-shot turbo spin-echo) in a mid-sagittal plane of the uterus. HASTE images were taken twice for each study and displayed in cine mode at 17 times real speed. Assessments were based on: a) detectability of uterine peristalsis on cine mode and b) peristaltic frequency and direction. Correlation between subjects taking OCs and the controls was examined. MR imaging demonstrated a marked decrease in the ability to identify uterine peristalsis in the subjects taking OCs (3/20 versus 16/16). Peristaltic frequency was less in OC users (0.4±0.2/min) than in the control group (2.3±0.5/mim). OCs markedly suppressed uterine peristalsis at mid-cycle. Suppressed peristalsis may result in suppression of sperm transport through the uterine cavity. (author)