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Sample records for canonical low-hard state

  1. A magnetic model for low/hard state of black hole binaries

    CERN Document Server

    Ye, Yong-Chun; Huang, Chang-Yin; Cao, Xiao-Feng

    2015-01-01

    A magnetic model for low/hard state (LHS) of black hole X-ray binaries (BHXBs),H1743-322 and GX 339-4, is proposed based on the transportation of magnetic field from a companion into an accretion disk around a black hole (BH). This model consists of a truncated thin disk with an inner advection-dominated accretion flow (ADAF). The spectral profiles of the sources are fitted in agreement with the data observed at four different dates corresponding to the rising phase of the LHS. In addition, the association of the LHS with quasi-steady jet is modelled based on transportation of magnetic field, where the Blandford-Znajek (BZ) and Blandford-Payne (BP) processes are invoked to drive the jets from BH and inner ADAF. It turns out that the steep radio/X-ray correlations observed in H1743-322 and GX 339-4 can be interpreted based on our model.

  2. Spectral and Timing Studies of Cyg X-1 in the Low/Hard State with Suzaku

    CERN Document Server

    Torii, Shunsuke; Makishima, Kazuo; Sakurai, Soki; Nakazawa, Kazuhiro; Noda, Hirofumi; Done, Chris; Takahashi, Hiromitsu; Gandhi, Poshak

    2011-01-01

    From 2005 to 2009, 25 observations of Cyg X-1 were performed with Suzaku, achieving a total exposure of 446 ks. In all observations, the source was found in the low/hard state, while the 1.5--12.0 keV count rate of the All-Sky Monitor onboard RXTE varied by a factor of ~ 3. In each observation, the 10--60 keV HXD-PIN spectrum and the 60--400 keV HXD-GSO spectrum were fitted successfully by a thermal Comptonization model plus reflection by a thick neutral material. As the soft X-ray intensity increased, the Compton y-parameter was found to decrease from 1.0 to 0.6, while the solid angle of reflection to increase by ~ 30%. Also conducted was timing analysis over a frequency range of 0.001--10 Hz. As the source became brighter in soft X-rays, the characteristic frequency of hard X-ray variation increased from 0.03 to 0.3 Hz, while the fractional hard X-ray variation integrated over 0.001--0.01 Hz decreased by a factor of ~ 5. The signals in the 60--200 keV band were generally found to vary on shorter time scales...

  3. Confirming the thermal Comptonization model for black hole X-ray emission in the low-hard state

    CERN Document Server

    Castro, M; Braga, J; Maiolino, T; Pottschmidt, K; Wilms, J

    2014-01-01

    Hard X-ray spectra of black hole binaries in the low/hard state are well modeled by thermal Comptonization of soft seed photons by a corona-type region with $kT$\\thinspace$\\sim 50${\\thinspace}keV and optical depth around 1. Previous spectral studies of 1E{\\thinspace}1740.7$-$2942, including both the soft and the hard X-ray bands, were always limited by gaps in the spectra or by a combination of observations with imaging and non-imaging instruments. In this study, we have used three rare nearly-simultaneous observations of 1E{\\thinspace}1740.7$-$1942 by both XMM-Newton and INTEGRAL satellites to combine spectra from four different imaging instruments with no data gaps, and we successfully applied the Comptonization scenario to explain the broadband X-ray spectra of this source in the low/hard state. For two of the three observations, our analysis also shows that, models including Compton reflection can adequately fit the data, in agreement with previous reports. We show that the observations can also be modele...

  4. Simultaneous independent measurements of a truncated inner accretion disc in the low/hard state of GX 399$-$4

    CERN Document Server

    Plant, D S; Fender, R P

    2014-01-01

    We present results from three recent XMM-Newton observations of GX 339$-$4 in the low/hard state, taken during the decay of a bright (peak $\\sim 0.05$ L$_{\\rm Edd}$) failed outburst. Uniquely, these are the first XMM-Newton EPIC-pn observations of this source using an imaging mode, which significantly enhances the quality of the data at hand. In particular, thanks to the larger available bandpass, this allows an unprecedented constraint of the thermal accretion disc component, and the level of photoelectric absorption. We simultaneously measured the inner radius of the accretion disc via the broadened Fe K$\\alpha$ line and the disc component. The two methods agree, and the measured radii show good consistency over the three epochs. We find that the inner radius is at 20-30 $r_{\\rm g}$, adding to the growing direct evidence for truncation of the inner accretion disc in the low/hard state.

  5. A disk-corona model for low/hard state of black hole X-ray binaries

    CERN Document Server

    Wang, Jiu-Zhou; Huang, Chang-Yin

    2013-01-01

    A disk-corona model for fitting low/hard (LH) state of associated steady jet of black hole X-ray binaries (BHXBs) is proposed based on the large-scale magnetic field configuration of the coexistence of the Blandford-Znajek (BZ) and Blandford-Payne (BP) processes,where the magnetic field configuration for the BP process is determined by the requirement of energy conversion from Poynting energy flux into kinetic energy flux in the jet. It is found that corona current is crucial to guarantee the consistency of the jet launching from accretion disk. The relative importance of the BZ to BP processes in powering jets from black hole accretion disk is discussed, and the LH state of several BHXBs is fitted based on our model.In addition, we suggest that magnetic field configuration could be regarded as the second parameter for governing the state transition of BHXBs.

  6. NuSTAR and INTEGRAL observations of a low/hard state of 1E1740.7-2942

    DEFF Research Database (Denmark)

    Natalucci, Lorenzo; Tomsick, John A.; Bazzano, Angela

    2014-01-01

    The microquasar 1E1740.7-2942, also known as the "Great Annihilator", was observed by NuSTAR in the Summer of 2012. We have analyzed in detail two observations taken ~2 weeks apart, for which we measure hard and smooth spectra typical of the low/hard state. A few weeks later the source flux......STAR, with the measurements being compatible with a change in flux with no spectral variability. We present a detailed analysis of the NuSTAR spectral and timing data and upper limits for reflection of the high energy emission. We show that the high energy spectrum of this X-ray binary is well described by thermal...

  7. NuSTAR and integral observations of a low/hard state of 1E1740.7-2942

    Energy Technology Data Exchange (ETDEWEB)

    Natalucci, Lorenzo; Bazzano, Angela; Fiocchi, Mariateresa; Ubertini, Pietro [Istituto di Astrofisica e Planetologia Spaziali, INAF, via del Fosso del Cavaliere, I-00133 Roma (Italy); Tomsick, John A.; Boggs, Steven E.; Craig, William W.; Krivonos, Roman [Space Sciences Laboratory, 7 Gauss Way, University of California, Berkeley, CA 94720-7450 (United States); Smith, David M. [Physics Department and Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, CA 95064 (United States); Bachetti, Matteo; Barret, Didier [Université de Toulouse, UPS-OMP, IRAP, Toulouse (France); Christensen, Finn E. [DTU Space, National Space Institute, Technical University of Denmark, Elektrovej 327, DK-2800 Lyngby (Denmark); Fürst, Felix; Grefenstette, Brian W.; Harrison, Fiona A. [Cahill Center for Astronomy and Astrophysics, California Institute of Technology, Pasadena, CA 91125 (United States); Hailey, Charles J. [Columbia Astrophysics Laboratory, Columbia University, New York, NY 10027 (United States); Kuulkers, Erik [European Space Astronomy Centre (ESA/ESAC), Science Operations Department, E-28691 Villanueva de la Cañada (Madrid) (Spain); Miller, Jon M. [Department of Astronomy, University of Michigan, 500 Church Street, Ann Arbor, MI 48109 (United States); Pottschmidt, Katja [CRESST and NASA Goddard Space Flight Center, Astrophysics Science Division, Code 661, Greenbelt, MD 20771 (United States); Stern, Daniel, E-mail: lorenzo.natalucci@iaps.inaf.it [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); and others

    2014-01-01

    The microquasar 1E1740.7-2942, also known as the 'Great Annihilator,' was observed by NuSTAR in the summer of 2012. We have analyzed in detail two observations taken ∼2 weeks apart, for which we measure hard and smooth spectra typical of the low/hard state. A few weeks later the source flux declined significantly. Nearly simultaneous coverage by INTEGRAL is available from its Galactic Center monitoring campaign lasting ∼2.5 months. These data probe the hard state spectrum from 1E1740.7-2942 before the flux decline. We find good agreement between the spectra taken with IBIS/ISGRI and NuSTAR, with the measurements being compatible with a change in flux with no spectral variability. We present a detailed analysis of the NuSTAR spectral and timing data and upper limits for reflection of the high energy emission. We show that the high energy spectrum of this X-ray binary is well described by thermal Comptonization.

  8. NuSTAR and INTEGRAL observations of a low/hard state of 1E1740.7-2942

    CERN Document Server

    Natalucci, Lorenzo; Bazzano, Angela; Smith, David M; Bachetti, Matteo; Barret, Didier; Boggs, Steven E; Christensen, Finn E; Craig, William W; Fiocchi, Mariateresa; Fuerst, Felix; Grefenstette, Brian W; Hailey, Charles J; Harrison, Fiona A; Krivonos, Roman; Kuulkers, Erik; Miller, Jon M; Pottschmidt, Katja; Stern, Daniel; Ubertini, Pietro; Walton, Dominic J; Zhang, William W

    2013-01-01

    The microquasar 1E1740.7-2942, also known as the "Great Annihilator", was observed by NuSTAR in the Summer of 2012. We have analyzed in detail two observations taken ~2 weeks apart, for which we measure hard and smooth spectra typical of the low/hard state. A few weeks later the source flux declined significantly. Nearly simultaneous coverage by INTEGRAL is available from its Galactic Center monitoring campaign lasting ~2.5 months. These data probe the hard state spectrum from 1E1740.7-2942 before the flux decline. We find good agreement between the spectra taken with IBIS/ISGRI and NuSTAR, with the measurements being compatible with a change in flux with no spectral variability. We present a detailed analysis of the NuSTAR spectral and timing data and upper limits for reflection of the high energy emission. We show that the high energy spectrum of this X-ray binary is well described by thermal Comptonization.

  9. New Constraints on the Black Hole Low/Hard State Inner Accretion Flow with NuSTAR

    CERN Document Server

    Miller, J M; Bachetti, M; Wilkins, D; Boggs, S E; Chistensen, F E; Craig, W W; Fabian, A C; Grefenstette, B W; Hailey, C J; Harrison, F A; Kara, E; King, A L; Stern, D K; Zhang, W W

    2014-01-01

    We report on an observation of the Galactic black hole candidate GRS 1739-278 during its 2014 outburst, obtained with NuSTAR. The source was captured at the peak of a rising "low/hard" state, at a flux of ~0.3 Crab. A broad, skewed iron line and disk reflection spectrum are revealed. Fits to the sensitive NuSTAR spectra with a number of relativistically blurred disk reflection models yield strong geometrical constraints on the disk and hard X-ray "corona". Two models that explicitly assume a "lamppost" corona find its base to have a vertical height above the black hole of h = 5 (+7, -2) GM/c^2 and h = 18 +/-4 GM/c^2 (90% confidence errors); models that do not assume a "lamppost" return emissivity profiles that are broadly consistent with coronae of this size. Given that X-ray microlensing studies of quasars and reverberation lags in Seyferts find similarly compact coronae, observations may now signal that compact coronae are fundamental across the black hole mass scale. All of the models fit to GRS 1739-278 f...

  10. MAXI observations of long-term variations of Cygnus X-1 in the low/hard and the high/soft states

    CERN Document Server

    Sugimoto, Juri; Kitamoto, Shunji; Matsuoka, Masaru; Sugizaki, Mutsumi; Negoro, Hitoshi; Nakahira, Satoshi; Makishima, Kazuo

    2016-01-01

    Long-term X-ray variability of the black hole binary, Cygnus X-1, was studied with five years of MAXI data from 2009 to 2014, which include substantial periods of the high/soft state, as well as the low/hard state. In each state, Normalized Power Spectrum densities (NPSDs) were calculated in three energy bands of 2-4 keV, 4-10 keV and 10-20 keV. The NPSDs in a frequency from 1e-7 Hz to 1e-4 Hz are all approximated by a power-law function with an index -1.35 ~ -1.29. The fractional RMS variation ($\\eta$), calculated in the above frequency range, was found to show the following three properties; (1) $\\eta$ slightly decreases with energy in the low/hard state; (2) $\\eta$ increases towards higher energies in the high/soft state; and (3) in the 10-20 keV band, $\\eta$ is 3 times higher in the high/soft state than in the low/hard state. These properties were confirmed through studies of intensity-correlated changes of the MAXI spectra. Of these three findings, the first one is consistent with that seen in the short-...

  11. Low-Luminosity AGN as analogues of Galactic Black Holes in the low/hard state: Evidence from X-ray timing of NGC 4258

    CERN Document Server

    Markowitz, A

    2005-01-01

    We present a broadband power spectral density function (PSD) measured from extensive RXTE monitoring data of the low-luminosity AGN NGC 4258, which has an accurate, maser-determined black hole mass of 3.9+/-0.1 * 10^7 solar masses. We constrain the PSD break timescale to be greater than 4.5 d at >90% confidence, which appears to rule out the possibility that NGC 4258 is an analogue of black hole X-ray binaries (BHXRBs) in the high/soft state. In this sense, the PSD of NGC 4258 is different to those of some more-luminous Seyferts, which appear similar to the PSDs of high/soft state X-ray binaries. This result supports previous analogies between LLAGN and X-ray binaries in the low/hard state based on spectral energy distributions, indicating that the AGN/BHXRB analogy is valid across a broad range of accretion rates.

  12. Canonical Quantum Teleportation of Two-Particle Arbitrary State

    Institute of Scientific and Technical Information of China (English)

    HAO Xiang; ZHU Shi-Qun

    2005-01-01

    The canonical quantum teleportation of two-particle arbitrary state is realized by means of phase operator and number operator. The maximally entangled eigenstates between the difference of phase operators and the sum of number operators are considered as the quantum channels. In contrast to the standard quantum teleportation, the different unitary local operation of canonical teleportation can be simplified by a general expression.

  13. Low-Luminosity AGN As Analogues of Galactic Black Holes in the Low/Hard State: Evidence from X-Ray Timing of NGC 4258

    Science.gov (United States)

    Markowitz, A.; Uttley, P.

    2005-01-01

    We present a broadband power spectral density function (PSD) measured from extensive RXTE monitoring data of the low-luminosity AGN NGC 4258, which has an accurate, maser-determined black hole mass of (3.9 plus or minus 0.1) x 10(exp 7) solar mass. We constrain the PSD break time scale to be greater than 4.5 d at greater than 90% confidence, which appears to rule out the possibility that NGC 4258 is an analogue of black hole X-ray binaries (BHXRBs) in the high/soft state. In this sense, the PSD of NGC 4258 is different to that of some more-luminous Seyferts, which appear similar to the PSDs of high/soft state X-ray binaries. This result supports previous analogies between LLAGN and X-ray binaries in the low/hard state based on spectral energy distributions, indicating that the AGN/BHXRB analogy is valid across a broad range of accretion rates.

  14. Repeated Short-term Spectral Softening in the Low/Hard State of the Galactic Black-Hole Candidate Swift J1753.5-0127

    CERN Document Server

    Yoshikawa, Akifumi; Nakahira, Satoshi; Matsuoka, Masaru; Negoro, Hitoshi; Mihara, Tatehiro; Tamagawa, Toru

    2015-01-01

    We report MAXI and Swift observations of short-term spectral softenings of the galactic black-hole X-ray binary Swift J1753.5-0127 in the low/hard state. These softening events are characterized by a simultaneous increase of soft X-rays (2-4 keV) and a decrease of hard X-rays (15-50 keV) lasting for a few tens of days. The X-ray energy spectra during the softening periods can be reproduced with a model consisting of a multi-color disk blackbody and its Comptonized component. The fraction of the Comptonized component decreased from 0.30 to 0.15 when the spectrum became softer; meanwhile the inner disk temperature (Tin) increased from 0.2 to 0.45 keV. These results imply that the softening events are triggered by a short-term increase of the mass accretion rate. During the observed spectral softening events, the disk flux (F) and Tin did not obey the relation: F is proportional to Tin^4, suggesting that the inner disk radius does not reach the innermost stable circular orbit.

  15. Rapid optical and X-ray timing observations of GX 339-4: flux correlations at the onset of a low/hard state

    CERN Document Server

    Gandhi, P; Durant, M; Fabian, A C; Dhillon, V S; Marsh, T R; Miller, J M; Shahbaz, T; Spruit, H C

    2008-01-01

    We present the discovery of optical/X-ray flux correlations on rapid timescales in the low/hard state of the Galactic black hole GX 339-4. The source had recently emerged from outburst and was associated with a relatively-faint counterpart with mag V~17. The optical (VLT/ULTRACAM) and X-ray (RXTE/PCA) data show a clear positive cross-correlation function (CCF) signal, with the optical peak lagging X-rays by ~ 150 ms, preceded by a shallow rise and followed by a steep decline along with broad anti-correlation dips. Examination of the light curves shows that the main CCF features are reproduced in superpositions of flares and dips. The CCF peak is narrow and the X-ray auto-correlation function (ACF) is broader than the optical ACF, arguing against reprocessing as the origin for the rapid optical emission. X-ray flaring is associated with spectral hardening, but no corresponding changes are detected around optical peaks and dips. The variability may be explained in the context of synchrotron emission with intera...

  16. Quantum oscillators in the canonical coherent states

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, R. de Lima [Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro, RJ (Brazil); Lima, A.F. de; Ferreira, K. de Araujo [Paraiba Univ., Campina Grande, PB (Brazil). Dept. de Fisica; Vaidya, A.N. [Universidade Federal, Rio de Janeiro, RJ (Brazil). Inst. de Fisica

    2001-11-01

    The main characteristics of the quantum oscillator coherent states including the two-particle Calogero interaction are investigated. We show that these Calogero coherent states are the eigenstates of the second-order differential annihilation operator which is deduced via Wigner-Heisenberg algebraic technique and correspond exactly to the pure uncharged-bosonic states. They posses the important properties of non-orthogonality and completeness. The minimum uncertainty relation for the Wigner oscillator coherent states are investigated. New sets of even and odd coherent states are point out. (author)

  17. Representations of Canonical Commutation Relations Describing Infinite Coherent States

    Science.gov (United States)

    Joye, Alain; Merkli, Marco

    2016-10-01

    We investigate the infinite volume limit of quantized photon fields in multimode coherent states. We show that for states containing a continuum of coherent modes, it is mathematically and physically natural to consider their phases to be random and identically distributed. The infinite volume states give rise to Hilbert space representations of the canonical commutation relations which we construct concretely. In the case of random phases, the representations are random as well and can be expressed with the help of Itô stochastic integrals. We analyze the dynamics of the infinite state alone and the open system dynamics of small systems coupled to it. We show that under the free field dynamics, initial phase distributions are driven to the uniform distribution. We demonstrate that coherences in small quantum systems, interacting with the infinite coherent state, exhibit Gaussian time decay. The decoherence is qualitatively faster than the one caused by infinite thermal states, which is known to be exponentially rapid only. This emphasizes the classical character of coherent states.

  18. The optimal pure Gaussian state canonically associated to a Gaussian quantum state

    Energy Technology Data Exchange (ETDEWEB)

    Gosson, Maurice de [Blekinge Institute of Technology, Karlskrona 371 79 (Sweden)]. E-mail: mdg@bth.se

    2004-09-20

    We show, using the symplectically invariant notion of 'quantum blob', that it is possible to attach a canonical optimal Gaussian pure state to an arbitrary quantum state. When at least one pair of conjugate variables satisfies the minimum uncertainty condition, then the associated Gaussian is uniquely determined up to an overall phase factor.

  19. Chandra X-ray spectroscopy of the focused wind in the Cygnus X-1 system I. The non-dip spectrum in the low/hard state

    CERN Document Server

    Hanke, Manfred; Nowak, Michael A; Pottschmidt, Katja; Schulz, Norbert S; Lee, Julia C

    2008-01-01

    We present analyses of a 50 ks observation of the supergiant X-ray binary system Cygnus X-1/HDE 226868 taken with the Chandra High Energy Transmission Grating Spectrometer (HETGS). Cyg X-1 was in its spectrally hard state and the observation was performed during superior conjunction of the black hole, allowing for the spectroscopic analysis of the accreted stellar wind along the line of sight. A significant part of the observation covers X-ray dips as commonly observed for Cyg X-1 at this orbital phase, however, here we only analyze the high count rate non-dip spectrum. The full 0.5-10 keV continuum can be described by a single model consisting of a disk, a narrow and a relativistically broadened Fe Kalpha line, and a power law component, which is consistent with simultaneous RXTE broad band data. We detect absorption edges from overabundant neutral O, Ne and Fe, and absorption line series from highly ionized ions and infer column densities and Doppler shifts. With emission lines of He-like Mg XI, we detect t...

  20. Spectral analysis of the XMM-Newton data of GX 339-4 in the low/hard state: disc truncation and reflection

    CERN Document Server

    Basak, Rupal

    2015-01-01

    We analyse all available observations of GX 339--4 by XMM-Newton in the hard spectral state. We jointly fit the spectral data by Comptonisation and the currently best reflection code, relxill. We consider in detail a contribution from a standard blackbody accretion disc, testing whether its inner radius can be set equal to that of the reflector. However, this leads to an unphysical behaviour of the disc truncation radius, implying the soft X-ray component is not a standard blackbody disc. This is due to irradiation by the hard X-rays, which strongly dominate the total emission. We thus treat the soft component phenomenologically. We consider a large array of models, testing, e.g., the effects of the chosen energy range, the radial irradiation profile, adding unblurred reflection, and assuming a lamppost geometry. We find the effects of relativistic broadening to be relatively weak in all cases. In the coronal models, we find the inner radius to be large. In the lamppost model, the inner radius is unconstraine...

  1. Spontaneous conscious covert cognition states and brain electric spectral states in canonical correlations.

    Science.gov (United States)

    Lehmann, D; Grass, P; Meier, B

    1995-02-01

    Correlations between subjective, conscious, spontaneous cognitions and EEG power spectral profiles were investigated in 20 normal volunteers (2 sessions each) during relaxation-drowsiness-sleep onset. Four-channel EEG (temporal-parietal and parietal-central, left and right) was continuously recorded. The subjects were prompted 15 times per session to give brief reports of their ongoing thoughts. The reports were rated on 23 scales, and the 16 seconds of EEG recording preceding the prompts were spectral analyzed. Canonical correlation analysis was applied to the data (23 cognition ratings and 124 EEG spectral values for each of the 538 prompts). Four of the 23 pairs of canonical EEG variables and cognition variables were significant (p covert, cognitive-emotional states in a no-input, no-task, no-response paradigm.

  2. State-Vector Space and Canonical Coherent States in Noncommutative Plane

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The structure of the state-vector space of identical bosons in noncommutative spaces is investigated. To maintain Bose-Einstein statistics the commutation relations of phase space variables should simultaneously include coordinate-coordinate non-commutativity and momentum-momentum non-commutativity, which leads to a kind of de-formed Heisenberg-Weyl algebra. Although there is no ordinary number representation in this state-vector space, several set of orthogonal and complete state-vectors can be derived which are common eigenvectors of corresponding pairs of commuting Hermitian operators. As a simple application of this state-vector space, an explicit form of two-dimensional canonical coherent state is constructed and its properties are discussed.

  3. Source Localization of Brain States Associated with Canonical Neuroimaging Postures.

    Science.gov (United States)

    Lifshitz, Michael; Thibault, Robert T; Roth, Raquel R; Raz, Amir

    2017-02-14

    Cognitive neuroscientists rarely consider the influence that body position exerts on brain activity; yet, postural variation holds important implications for the acquisition and interpretation of neuroimaging data. Whereas participants in most behavioral and EEG experiments sit upright, many prominent brain imaging techniques (e.g., fMRI) require participants to lie supine. Here we demonstrate that physical comportment profoundly alters baseline brain activity as measured by magnetoencephalography (MEG)-an imaging modality that permits multipostural acquisition. We collected resting-state MEG data from 12 healthy participants in three postures (lying supine, reclining at 45°, and sitting upright). Source-modeling analysis revealed a broadly distributed influence of posture on resting brain function. Sitting upright versus lying supine was associated with greater high-frequency (i.e., beta and gamma) activity in widespread parieto-occipital cortex. Moreover, sitting upright and reclined postures correlated with dampened activity in prefrontal regions across a range of bandwidths (i.e., from alpha to low gamma). The observed effects were large, with a mean Cohen's d of 0.95 (SD = 0.23). In addition to neural activity, physiological parameters such as muscle tension and eye blinks may have contributed to these posture-dependent changes in brain signal. Regardless of the underlying mechanisms, however, the present results have important implications for the acquisition and interpretation of multimodal imaging data (e.g., studies combining fMRI or PET with EEG or MEG). More broadly, our findings indicate that generalizing results-from supine neuroimaging measurements to erect positions typical of ecological human behavior-would call for considering the influence that posture wields on brain dynamics.

  4. The canonical versrus path integral quantization approach to generalized Kodama states (Part I)

    CERN Document Server

    Ita, Eyo Eyo

    2007-01-01

    This is the fifth paper in the series outlining an algorithm to consistently quantize four-dimensional gravity. We derive the pure Kodama state in analogy to the no-boundary proposal for constructing quantum gravitational wavefunctions, checking at each stage of the process the equivalence of the canonical and path integral approaches. A family of additional pure Kodama states is identified via the canonical approach and a criterion for their suitability as a basis of states is examined. We provide an interpretation for the problem of time within the context of the generalized Kodama states and propose a possible method of resolution. We also develop different techniques for solving the Gauss' law constraintsd at the kinematical level, in preparation for future work in this series.

  5. Hamiltonian models of multiphoton processes and four--photon squeezed states via nonlinear canonical transformations

    CERN Document Server

    De Siena, S; Illuminati, F; Siena, Silvio De; Lisi, Antonio Di; Illuminati, Fabrizio

    2002-01-01

    We introduce nonlinear canonical transformations that yield effective Hamiltonians of multiphoton down conversion processes, and we define the associated non-Gaussian multiphoton squeezed states as the coherent states of the multiphoton Hamiltonians. We study in detail the four-photon processes and the associated non-Gaussian four-photon squeezed states. The realization of squeezing, the behavior of the field statistics, and the structure of the phase space distributions show that these states realize a natural four-photon generalization of the two-photon squeezed states.

  6. Structure of multiphoton quantum optics. I. Canonical formalism and homodyne squeezed states

    Science.gov (United States)

    dell'Anno, Fabio; de Siena, Silvio; Illuminati, Fabrizio

    2004-03-01

    We introduce a formalism of nonlinear canonical transformations for general systems of multiphoton quantum optics. For single-mode systems the transformations depend on a tunable free parameter, the homodyne local-oscillator angle; for n -mode systems they depend on n heterodyne mixing angles. The canonical formalism realizes nontrivial mixing of pairs of conjugate quadratures of the electromagnetic field in terms of homodyne variables for single-mode systems, and in terms of heterodyne variables for multimode systems. In the first instance the transformations yield nonquadratic model Hamiltonians of degenerate multiphoton processes and define a class of non-Gaussian, nonclassical multiphoton states that exhibit properties of coherence and squeezing. We show that such homodyne multiphoton squeezed states are generated by unitary operators with a nonlinear time evolution that realizes the homodyne mixing of a pair of conjugate quadratures. Tuning of the local-oscillator angle allows us to vary at will the statistical properties of such states. We discuss the relevance of the formalism for the study of degenerate (up-)down-conversion processes. In a companion paper [ F. Dell’Anno, S. De Siena, and F. Illuminati, 69, 033813 (2004) ], we provide the extension of the nonlinear canonical formalism to multimode systems, we introduce the associated heterodyne multiphoton squeezed states, and we discuss their possible experimental realization.

  7. Structure of multiphoton quantum optics. I. Canonical formalism and homodyne squeezed states

    CERN Document Server

    Dell'Anno, F; Illuminati, F; Anno, Fabio Dell'; Siena, Silvio De; Illuminati, Fabrizio

    2004-01-01

    We introduce a formalism of nonlinear canonical transformations for general systems of multiphoton quantum optics. For single-mode systems the transformations depend on a tunable free parameter, the homodyne local oscillator angle; for n-mode systems they depend on n heterodyne mixing angles. The canonical formalism realizes nontrivial mixings of pairs of conjugate quadratures of the electromagnetic field in terms of homodyne variables for single-mode systems; and in terms of heterodyne variables for multimode systems. In the first instance the transformations yield nonquadratic model Hamiltonians of degenerate multiphoton processes and define a class of non Gaussian, nonclassical multiphoton states that exhibit properties of coherence and squeezing. We show that such homodyne multiphoton squeezed states are generated by unitary operators with a nonlinear time evolution that realizes the homodyne mixing of a pair of conjugate quadratures. Tuning of the local oscillator angle allows to vary at will the statist...

  8. Probing Gravitational Cat States in Canonical Quantum Theory vs Objective Collapse Theories

    OpenAIRE

    Derakhshani, Maaneli

    2016-01-01

    Using as a testbed the recently proposed "gravcat" experimental scheme in [1], we compare the properties of gravitational cat states in three descriptions: (1) canonical quantum theory (CQT) combined with the Newtonian limit of GR, (2) objective collapse theories (OCTs) extended to the regime of semiclassical Newtonian gravity, and (3) OCTs extended to incorporate quantized Newtonian gravity. For the CQT approach, we follow the treatment of Hu and Anastopoulos in [2]. For the OCTs, we conside...

  9. Physical states in the canonical tensor model from the perspective of random tensor networks

    Science.gov (United States)

    Narain, Gaurav; Sasakura, Naoki; Sato, Yuki

    2015-01-01

    Tensor models, generalization of matrix models, are studied aiming for quantum gravity in dimensions larger than two. Among them, the canonical tensor model is formulated as a totally constrained system with first-class constraints, the algebra of which resembles the Dirac algebra of general relativity. When quantized, the physical states are defined to be vanished by the quantized constraints. In explicit representations, the constraint equations are a set of partial differential equations for the physical wave-functions, which do not seem straightforward to be solved due to their non-linear character. In this paper, after providing some explicit solutions for N = 2 , 3, we show that certain scale-free integration of partition functions of statistical systems on random networks (or random tensor networks more generally) provides a series of solutions for general N. Then, by generalizing this form, we also obtain various solutions for general N. Moreover, we show that the solutions for the cases with a cosmological constant can be obtained from those with no cosmological constant for increased N. This would imply the interesting possibility that a cosmological constant can always be absorbed into the dynamics and is not an input parameter in the canonical tensor model. We also observe the possibility of symmetry enhancement in N = 3, and comment on an extension of Airy function related to the solutions.

  10. Physical states in the canonical tensor model from the perspective of random tensor networks

    CERN Document Server

    Narain, Gaurav; Sato, Yuki

    2014-01-01

    Tensor models, generalization of matrix models, are studied aiming for quantum gravity in dimensions larger than two. Among them, the canonical tensor model is formulated as a totally constrained system with first-class constraints, the algebra of which resembles the Dirac algebra of general relativity. When quantized, the physical states are defined to be vanished by the quantized constraints. In explicit representations, the constraint equations are a set of partial differential equations for physical wave-functions, which do not seem straightforward to solve due to their non-linear character. In this paper, after providing some explicit solutions for N = 2,3, we show that certain scale-free integration of partition functions of statistical systems on random networks, or random tensor networks more generally, provides a series of solutions for general N. Then, by generalizing this form, we also obtain various solutions for general N. Moreover, we show that the solutions for the cases with a cosmological con...

  11. Non-Canonical and Sexually Dimorphic X Dosage Compensation States in the Mouse and Human Germline.

    Science.gov (United States)

    Sangrithi, Mahesh N; Royo, Helene; Mahadevaiah, Shantha K; Ojarikre, Obah; Bhaw, Leena; Sesay, Abdul; Peters, Antoine H F M; Stadler, Michael; Turner, James M A

    2017-02-06

    Somatic X dosage compensation requires two mechanisms: X inactivation balances X gene output between males (XY) and females (XX), while X upregulation, hypothesized by Ohno and documented in vivo, balances X gene with autosomal gene output. Whether X dosage compensation occurs in germ cells is unclear. We show that mouse and human germ cells exhibit non-canonical X dosage states that differ from the soma and between the sexes. Prior to genome-wide reprogramming, X upregulation is present, consistent with Ohno's hypothesis. Subsequently, however, it is erased. In females, erasure follows loss of X inactivation, causing X dosage excess. Conversely, in males, erasure leads to permanent X dosage decompensation. Sex chromosomally abnormal models exhibit a "sex-reversed" X dosage state: XX males, like XX females, develop X dosage excess, while XO females, like XY males, develop X dosage decompensation. Thus, germline X dosage compensation states are determined by X chromosome number, not phenotypic sex. These unexpected differences in X dosage compensation states between germline and soma offer unique perspectives on sex chromosome infertility.

  12. Canonical Typicality

    OpenAIRE

    Goldstein, Sheldon; Lebowitz, Joel L.; Tumulka, Roderich; Zanghi, Nino

    2005-01-01

    It is well known that a system, S, weakly coupled to a heat bath, B, is described by the canonical ensemble when the composite, S+B, is described by the microcanonical ensemble corresponding to a suitable energy shell. This is true both for classical distributions on the phase space and for quantum density matrices. Here we show that a much stronger statement holds for quantum systems. Even if the state of the composite corresponds to a single wave function rather than a mixture, the reduced ...

  13. Chandra X-Ray Spectroscopy of the Focused Wind in the Cygnus X-1 System. II. The Nondip Spectrum in the Low/Hard State - Modulations with Orbital Phase

    CERN Document Server

    Miškovičová, Ivica; Hanke, Manfred; Nowak, Michael A; Pottschmidt, Katja; Schulz, Norbert S; Grinberg, Victoria; Duro, Refiz; Madej, Oliwia K; Lohfink, Anne M; Rodriguez, Jérôme; Bel, Marion Cadolle; Bodaghee, Arash; Tomsick, John A; Lee, Julia C; Brown, Gregory V; Wilms, Jörn

    2016-01-01

    The accretion onto the black hole in the system HDE 226868/Cygnus X-1 is powered by the strong line driven stellar wind of the O-type donor star. We study the X-ray properties of the stellar wind in the hard state of Cyg X-1 as determined with data from the Chandra High Energy Transmission Gratings. Large density and temperature inhomogeneities are present in the wind, with a fraction of the wind consisting of clumps of matter with higher density and lower temperature embedded in a photoionized gas. Absorption dips observed in the light curve are believed to be caused by these clumps. This work concentrates on the non-dip spectra as a function of orbital phase. The spectra show lines of H-like and He-like ions of S, Si, Na, Mg, Al and highly ionized Fe (Fe xvii-Fe xxiv). We measure velocity shifts, column densities, and thermal broadening of the line series. The excellent quality of these five observations allows us to investigate the orbital phase dependence of these parameters. We show that the absorber is ...

  14. Communication: Reduced density matrices in molecular systems: Grand-canonical electron states

    Energy Technology Data Exchange (ETDEWEB)

    Bochicchio, Roberto C., E-mail: rboc@df.uba.ar [Departamento de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and IFIBA, CONICET, Ciudad Universitaria, 1428 Buenos Aires (Argentina); Miranda-Quintana, Ramón A. [Laboratory of Computational and Theoretical Chemistry, Faculty of Chemistry, University of Havana, Zapata e G y Mazón, 10400 Havana (Cuba); Rial, Diego [Departamento de Matemática, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and IMAS, CONICET, Ciudad Universitaria, 1428 Buenos Aires (Argentina)

    2013-11-21

    Grand-canonical like descriptions of many electron atomic and molecular open systems which are characterized by a non-integer number of electrons are presented. Their associated reduced density matrices (RDMs) are obtained by introducing the contracting mapping for this type of distributions. It is shown that there is loss of information when connecting RDMs of different order by partial contractions. The energy convexity property of these systems simplifies the description. Consequently, this formulation opens the possibility to a new look for chemical descriptors such as chemical potential and reactivity among others. Examples are presented to discuss the theoretical aspects of this work.

  15. Study of non-canonical scalar field model using various parametrizations of dark energy equation of state

    Energy Technology Data Exchange (ETDEWEB)

    Al Mamon, Abdulla; Das, Sudipta [Visva-Bharati, Department of Physics, Santiniketan (India)

    2015-06-15

    In this present work, we try to build up a cosmological model using a non-canonical scalar field within the framework of a spatially flat FRW space-time. In this context, we have considered four different parametrizations of the equation of state parameter of the non-canonical scalar field. Under this scenario, analytical solutions for various cosmological parameters have been found out. It has been found that the deceleration parameter shows a smooth transition from a positive value to some negative value which indicates that the universe was undergoing an early deceleration followed by late time acceleration which is essential for the structure formation of the universe. With these four parametrizations, the future evolution of the models are also discussed. It has been found that one of the models (Generalized Chaplygin gas model, GCG) mimics the concordance ΛCDM in the near future, whereas two other models (CPL and JBP) diverge due to future singularity. Finally, we have studied these theoretical models with the latest datasets from SN Ia + H(z) + BAO/CMB. (orig.)

  16. Grand canonical finite size numerical approaches in one and two dimensions: Real space energy renormalization and edge state generation

    Science.gov (United States)

    Hotta, Chisa; Nishimoto, Satoshi; Shibata, Naokazu

    2013-03-01

    The grand canonical numerical analysis recently developed for quantum many-body systems on a finite cluster [C. Hotta and N. Shibata, Phys. Rev. BPRBMDO1098-012110.1103/PhysRevB.86.041108 86, 041108(R) (2012)] is the technique to efficiently obtain the physical quantities in an applied field. There, the observables are the continuous and real functions of fields, mimicking their thermodynamic limit, even when a small cluster is adopted. We develop a theory to explain the mechanism of this analysis based on the deformation of the Hamiltonian. The deformation spatially scales down the energy unit from the system center toward zero at the open edge sites, which introduces the renormalization of the energy levels in a way reminiscent of Wilson's numerical renormalization group. However, compared to Wilson's case, our deformation generates a number of far well-localized edge states near the chemical potential level, which are connected via a very small quantum fluctuation in k space with the “bulk” states which spread at the center of the system. As a response to the applied field, the particles on the cluster are self-organized to tune the particle number of the bulk states to their thermodynamic limit by using the “edges” as a buffer. We demonstrate the present analysis in two-dimensional quantum spin systems on square and triangular lattices, and determine the smooth magnetization curve with a clear (1)/(3) plateau structure in the latter.

  17. Canonical Information Analysis

    DEFF Research Database (Denmark)

    Vestergaard, Jacob Schack; Nielsen, Allan Aasbjerg

    2015-01-01

    Canonical correlation analysis is an established multivariate statistical method in which correlation between linear combinations of multivariate sets of variables is maximized. In canonical information analysis introduced here, linear correlation as a measure of association between variables is ...... airborne data. The simulation study shows that canonical information analysis is as accurate as and much faster than algorithms presented in previous work, especially for large sample sizes. URL: http://www.imm.dtu.dk/pubdb/p.php?6270...

  18. Canonical-ensemble state-averaged complete active space self-consistent field (SA-CASSCF) strategy for problems with more diabatic than adiabatic states: Charge-bond resonance in monomethine cyanines

    Science.gov (United States)

    Olsen, Seth

    2015-01-01

    This paper reviews basic results from a theory of the a priori classical probabilities (weights) in state-averaged complete active space self-consistent field (SA-CASSCF) models. It addresses how the classical probabilities limit the invariance of the self-consistency condition to transformations of the complete active space configuration interaction (CAS-CI) problem. Such transformations are of interest for choosing representations of the SA-CASSCF solution that are diabatic with respect to some interaction. I achieve the known result that a SA-CASSCF can be self-consistently transformed only within degenerate subspaces of the CAS-CI ensemble density matrix. For uniformly distributed ("microcanonical") SA-CASSCF ensembles, self-consistency is invariant to any unitary CAS-CI transformation that acts locally on the ensemble support. Most SA-CASSCF applications in current literature are microcanonical. A problem with microcanonical SA-CASSCF models for problems with "more diabatic than adiabatic" states is described. The problem is that not all diabatic energies and couplings are self-consistently resolvable. A canonical-ensemble SA-CASSCF strategy is proposed to solve the problem. For canonical-ensemble SA-CASSCF, the equilibrated ensemble is a Boltzmann density matrix parametrized by its own CAS-CI Hamiltonian and a Lagrange multiplier acting as an inverse "temperature," unrelated to the physical temperature. Like the convergence criterion for microcanonical-ensemble SA-CASSCF, the equilibration condition for canonical-ensemble SA-CASSCF is invariant to transformations that act locally on the ensemble CAS-CI density matrix. The advantage of a canonical-ensemble description is that more adiabatic states can be included in the support of the ensemble without running into convergence problems. The constraint on the dimensionality of the problem is relieved by the introduction of an energy constraint. The method is illustrated with a complete active space valence

  19. Canonical-ensemble state-averaged complete active space self-consistent field (SA-CASSCF) strategy for problems with more diabatic than adiabatic states: Charge-bond resonance in monomethine cyanines

    Energy Technology Data Exchange (ETDEWEB)

    Olsen, Seth, E-mail: seth.olsen@uq.edu.au [School of Mathematics and Physics, The University of Queensland, Brisbane QLD 4072 (Australia)

    2015-01-28

    This paper reviews basic results from a theory of the a priori classical probabilities (weights) in state-averaged complete active space self-consistent field (SA-CASSCF) models. It addresses how the classical probabilities limit the invariance of the self-consistency condition to transformations of the complete active space configuration interaction (CAS-CI) problem. Such transformations are of interest for choosing representations of the SA-CASSCF solution that are diabatic with respect to some interaction. I achieve the known result that a SA-CASSCF can be self-consistently transformed only within degenerate subspaces of the CAS-CI ensemble density matrix. For uniformly distributed (“microcanonical”) SA-CASSCF ensembles, self-consistency is invariant to any unitary CAS-CI transformation that acts locally on the ensemble support. Most SA-CASSCF applications in current literature are microcanonical. A problem with microcanonical SA-CASSCF models for problems with “more diabatic than adiabatic” states is described. The problem is that not all diabatic energies and couplings are self-consistently resolvable. A canonical-ensemble SA-CASSCF strategy is proposed to solve the problem. For canonical-ensemble SA-CASSCF, the equilibrated ensemble is a Boltzmann density matrix parametrized by its own CAS-CI Hamiltonian and a Lagrange multiplier acting as an inverse “temperature,” unrelated to the physical temperature. Like the convergence criterion for microcanonical-ensemble SA-CASSCF, the equilibration condition for canonical-ensemble SA-CASSCF is invariant to transformations that act locally on the ensemble CAS-CI density matrix. The advantage of a canonical-ensemble description is that more adiabatic states can be included in the support of the ensemble without running into convergence problems. The constraint on the dimensionality of the problem is relieved by the introduction of an energy constraint. The method is illustrated with a complete active space

  20. Classifying Linear Canonical Relations

    OpenAIRE

    Lorand, Jonathan

    2015-01-01

    In this Master's thesis, we consider the problem of classifying, up to conjugation by linear symplectomorphisms, linear canonical relations (lagrangian correspondences) from a finite-dimensional symplectic vector space to itself. We give an elementary introduction to the theory of linear canonical relations and present partial results toward the classification problem. This exposition should be accessible to undergraduate students with a basic familiarity with linear algebra.

  1. Canonical and micro-canonical typical entanglement of continuous variable systems

    Energy Technology Data Exchange (ETDEWEB)

    Serafini, A [Institute for Mathematical Sciences, 53 Prince' s Gate, Imperial College London, London SW7 2PG (United Kingdom); Dahlsten, O C O [Institute for Mathematical Sciences, 53 Prince' s Gate, Imperial College London, London SW7 2PG (United Kingdom); Gross, D [Institute for Mathematical Sciences, 53 Prince' s Gate, Imperial College London, London SW7 2PG (United Kingdom); Plenio, M B [Institute for Mathematical Sciences, 53 Prince' s Gate, Imperial College London, London SW7 2PG (United Kingdom)

    2007-08-03

    We present a framework, compliant with the general canonical principle of statistical mechanics, to define measures on the set of pure Gaussian states of continuous variable systems. Within such a framework, we define two specific measures, referred to as 'micro-canonical' and 'canonical', and apply them to study systematically the statistical properties of the bipartite entanglement of n-mode pure Gaussian states at, respectively, given maximal energy and given temperature. We prove the 'concentration of measure' around a finite average, occurring for the entanglement in the thermodynamical limit in both the canonical and the micro-canonical approach. For finite n, we determine analytically the average and standard deviation of the entanglement (as quantified by the reduced purity) between one mode and all the other modes. Furthermore, we numerically investigate more general situations, clearly showing that the onset of the concentration of measure already occurs at relatively small n.

  2. Resting-state test-retest reliability of a priori defined canonical networks over different preprocessing steps.

    Science.gov (United States)

    Varikuti, Deepthi P; Hoffstaedter, Felix; Genon, Sarah; Schwender, Holger; Reid, Andrew T; Eickhoff, Simon B

    2016-08-22

    Resting-state functional connectivity analysis has become a widely used method for the investigation of human brain connectivity and pathology. The measurement of neuronal activity by functional MRI, however, is impeded by various nuisance signals that reduce the stability of functional connectivity. Several methods exist to address this predicament, but little consensus has yet been reached on the most appropriate approach. Given the crucial importance of reliability for the development of clinical applications, we here investigated the effect of various confound removal approaches on the test-retest reliability of functional-connectivity estimates in two previously defined functional brain networks. Our results showed that gray matter masking improved the reliability of connectivity estimates, whereas denoising based on principal components analysis reduced it. We additionally observed that refraining from using any correction for global signals provided the best test-retest reliability, but failed to reproduce anti-correlations between what have been previously described as antagonistic networks. This suggests that improved reliability can come at the expense of potentially poorer biological validity. Consistent with this, we observed that reliability was proportional to the retained variance, which presumably included structured noise, such as reliable nuisance signals (for instance, noise induced by cardiac processes). We conclude that compromises are necessary between maximizing test-retest reliability and removing variance that may be attributable to non-neuronal sources.

  3. [Canon Busting and Cultural Literacy.

    Science.gov (United States)

    National Forum: Phi Kappa Phi Journal, 1989

    1989-01-01

    Articles on literary canon include: "Educational Anomie" (Stephen W. White); "Why Western Civilization?" (William J. Bennett); "Peace Plan for Canon Wars" (Gerald Graff, William E. Cain); "Canons, Cultural Literacy, and Core Curriculum" (Lynne V. Cheney); "Canon Busting: Basic Issues" (Stanley Fish); "A Truce in Curricular Wars" (Chester E. Finn,…

  4. Covariant canonical quantization

    Energy Technology Data Exchange (ETDEWEB)

    Hippel, G.M. von [University of Regina, Department of Physics, Regina, Saskatchewan (Canada); Wohlfarth, M.N.R. [Universitaet Hamburg, Institut fuer Theoretische Physik, Hamburg (Germany)

    2006-09-15

    We present a manifestly covariant quantization procedure based on the de Donder-Weyl Hamiltonian formulation of classical field theory. This procedure agrees with conventional canonical quantization only if the parameter space is d=1 dimensional time. In d>1 quantization requires a fundamental length scale, and any bosonic field generates a spinorial wave function, leading to the purely quantum-theoretical emergence of spinors as a byproduct. We provide a probabilistic interpretation of the wave functions for the fields, and we apply the formalism to a number of simple examples. These show that covariant canonical quantization produces both the Klein-Gordon and the Dirac equation, while also predicting the existence of discrete towers of identically charged fermions with different masses. Covariant canonical quantization can thus be understood as a ''first'' or pre-quantization within the framework of conventional QFT. (orig.)

  5. Covariant canonical quantization

    CERN Document Server

    Von Hippel, G M; Hippel, Georg M. von; Wohlfarth, Mattias N.R.

    2006-01-01

    We present a manifestly covariant quantization procedure based on the de Donder-Weyl Hamiltonian formulation of classical field theory. Covariant canonical quantization agrees with conventional canonical quantization only if the parameter space is d=1 dimensional time. In d>1 quantization requires a fundamental length scale, and any bosonic field generates a spinorial wave function, leading to the purely quantum-theoretical emergence of spinors as a byproduct. We provide a probabilistic interpretation of the wave functions for the fields, and apply the formalism to a number of simple examples. These show that covariant canonical quantization produces both the Klein-Gordon and the Dirac equation, while also predicting the existence of discrete towers of identically charged fermions with different masses.

  6. Revisiting Canonical Quantization

    CERN Document Server

    Klauder, John R

    2012-01-01

    Conventional canonical quantization procedures directly link various c-number and q-number quantities. Here, we advocate a different association of classical and quantum quantities that renders classical theory a natural subset of quantum theory with \\hbar>0. While keeping the good results of conventional procedures, some examples are noted where the new procedures offer better results than conventional ones.

  7. Hopfion canonical quantization

    CERN Document Server

    Acus, A; Norvaisas, E; Shnir, Ya

    2012-01-01

    We study the effect of the canonical quantization of the rotational mode of the charge Q=1 and Q=2 spinning Hopfions. The axially-symmetric solutions are constructed numerically, it is shown the quantum corrections to the mass of the configurations are relatively large.

  8. Hopfion canonical quantization

    Energy Technology Data Exchange (ETDEWEB)

    Acus, A. [Vilnius University, Institute of Theoretical Physics and Astronomy, Gostauto 12, Vilnius 01108 (Lithuania); Halavanau, A. [Department of Theoretical Physics and Astrophysics, BSU, Minsk (Belarus); Norvaisas, E. [Vilnius University, Institute of Theoretical Physics and Astronomy, Gostauto 12, Vilnius 01108 (Lithuania); Shnir, Ya., E-mail: shnir@maths.tcd.ie [Department of Theoretical Physics and Astrophysics, BSU, Minsk (Belarus); Institute of Physics, Carl von Ossietzky University Oldenburg (Germany)

    2012-05-03

    We study the effect of the canonical quantization of the rotational mode of the charge Q=1 and Q=2 spinning Hopfions. The axially-symmetric solutions are constructed numerically, it is shown the quantum corrections to the mass of the configurations are relatively large.

  9. The canonical and grand canonical models for nuclear multifragmentation

    Indian Academy of Sciences (India)

    G Chaudhuri; S Das Gupta

    2010-08-01

    Many observables seen in intermediate energy heavy-ion collisions can be explained on the basis of statistical equilibrium. Calculations based on statistical equilibrium can be implemented in microcanonical ensemble, canonical ensemble or grand canonical ensemble. This paper deals with calculations with canonical and grand canonical ensembles. A recursive relation developed recently allows calculations with arbitrary precision for many nuclear problems. Calculations are done to study the nature of phase transition in nuclear matter.

  10. Higher Derivatives and Canonical Formalism

    OpenAIRE

    HAMAMOTO, Shinji

    1995-01-01

    A canonical formalism for higher-derivative theories is presented on the basis of Dirac's method for constrained systems. It is shown that this formalism shares a path integral expression with Ostrogradski's canonical formalism.

  11. Realizations of the Canonical Representation

    Indian Academy of Sciences (India)

    M K Vemuri

    2008-02-01

    A characterisation of the maximal abelian subalgebras of the bounded operators on Hilbert space that are normalised by the canonical representation of the Heisenberg group is given. This is used to classify the perfect realizations of the canonical representation.

  12. Canonical quantization of macroscopic electromagnetism

    Energy Technology Data Exchange (ETDEWEB)

    Philbin, T G, E-mail: tgp3@st-andrews.ac.u [School of Physics and Astronomy, University of St Andrews, North Haugh, St Andrews, Fife KY16 9SS (United Kingdom)

    2010-12-15

    Application of the standard canonical quantization rules of quantum field theory to macroscopic electromagnetism has encountered obstacles due to material dispersion and absorption. This has led to a phenomenological approach to macroscopic quantum electrodynamics where no canonical formulation is attempted. In this paper macroscopic electromagnetism is canonically quantized. The results apply to any linear, inhomogeneous, magnetodielectric medium with dielectric functions that obey the Kramers-Kronig relations. The prescriptions of the phenomenological approach are derived from the canonical theory.

  13. Canonical quantization of macroscopic electromagnetism

    CERN Document Server

    Philbin, T G

    2010-01-01

    Application of the standard canonical quantization rules of quantum field theory to macroscopic electromagnetism has encountered obstacles due to material dispersion and absorption. This has led to a phenomenological approach to macroscopic quantum electrodynamics where no canonical formulation is attempted. In this paper macroscopic electromagnetism is canonically quantized. The results apply to any linear, inhomogeneous, magnetoelectric medium with dielectric functions that obey the Kramers-Kronig relations. The prescriptions of the phenomenological approach are derived from the canonical theory.

  14. Canonical Strangeness Enhancement

    CERN Document Server

    Sollfrank, J; Redlich, Krzysztof; Satz, Helmut

    1998-01-01

    According to recent experimental data and theoretical developments we discuss three distinct topics related to strangeness enhancement in nuclear reactions. We investigate the compatibility of multi-strange particle ratios measured in a restricted phase space with thermal model parameters extracted recently in 4pi. We study the canonical suppression as a possible reason for the observed strangeness enhancement and argue that a connection between QGP formation and the undersaturation of strangeness is not excluded.

  15. Middleton beyond the Canon

    OpenAIRE

    2015-01-01

    The traditional vision of Middleton as a playwright depicted him as an author of city comedies and tragicomedies, who in his very last years suddenly approached the tragic genre. Among his last four plays, three composed in succession are tragedies: Hengist, 1620, Women Beware Women, 1621 and The Changeling, 1622; the last two are recognized as masterpieces. In the last forty years, Middleton’s canon has changed with new attributions. This paper analyses the new pattern emerging in Middleton’...

  16. Canonical Transformations of Kepler Trajectories

    Science.gov (United States)

    Mostowski, Jan

    2010-01-01

    In this paper, canonical transformations generated by constants of motion in the case of the Kepler problem are discussed. It is shown that canonical transformations generated by angular momentum are rotations of the trajectory. Particular attention is paid to canonical transformations generated by the Runge-Lenz vector. It is shown that these…

  17. Green's Conjecture for the generic canonical curve

    OpenAIRE

    Teixidor-I-Bigas, Montserrat

    1998-01-01

    Green's Conjecture states the following : syzygies of the canonical model of a curve are simple up to the p^th stage if and only if the Clifford index of C is greater than p. We prove that the generic curve of genus g satisfies Green's conjecture.

  18. Matrix product purifications for canonical ensembles and quantum number distributions

    Science.gov (United States)

    Barthel, Thomas

    2016-09-01

    Matrix product purifications (MPPs) are a very efficient tool for the simulation of strongly correlated quantum many-body systems at finite temperatures. When a system features symmetries, these can be used to reduce computation costs substantially. It is straightforward to compute an MPP of a grand-canonical ensemble, also when symmetries are exploited. This paper provides and demonstrates methods for the efficient computation of MPPs of canonical ensembles under utilization of symmetries. Furthermore, we present a scheme for the evaluation of global quantum number distributions using matrix product density operators (MPDOs). We provide exact matrix product representations for canonical infinite-temperature states, and discuss how they can be constructed alternatively by applying matrix product operators to vacuum-type states or by using entangler Hamiltonians. A demonstration of the techniques for Heisenberg spin-1 /2 chains explains why the difference in the energy densities of canonical and grand-canonical ensembles decays as 1 /L .

  19. Canonical quantization of constrained systems

    Energy Technology Data Exchange (ETDEWEB)

    Bouzas, A.; Epele, L.N.; Fanchiotti, H.; Canal, C.A.G. (Laboratorio de Fisica Teorica, Departamento de Fisica, Universidad Nacional de La Plata, Casilla de Correo No. 67, 1900 La Plata, Argentina (AR))

    1990-07-01

    The consideration of first-class constraints together with gauge conditions as a set of second-class constraints in a given system is shown to be incorrect when carrying out its canonical quantization.

  20. Uncertainty relations, zero point energy and the linear canonical group

    Science.gov (United States)

    Sudarshan, E. C. G.

    1993-01-01

    The close relationship between the zero point energy, the uncertainty relations, coherent states, squeezed states, and correlated states for one mode is investigated. This group-theoretic perspective enables the parametrization and identification of their multimode generalization. In particular the generalized Schroedinger-Robertson uncertainty relations are analyzed. An elementary method of determining the canonical structure of the generalized correlated states is presented.

  1. Observables in classical canonical gravity: folklore demystified

    CERN Document Server

    Pons, J M; Sundermeyer, K A

    2010-01-01

    We give an overview of some conceptual difficulties, sometimes called paradoxes, that have puzzled for years the physical interpetation of classical canonical gravity and, by extension, the canonical formulation of generally covariant theories. We identify these difficulties as stemming form some terminological misunderstandings as to what is meant by "gauge invariance", or what is understood classically by a "physical state". We make a thorough analysis of the issue and show that all purported paradoxes disappear when the right terminology is in place. Since this issue is connected with the search of observables - gauge invariant quantities - for these theories, we formally show that time evolving observables can be constructed for every observer. This construction relies on the fixation of the gauge freedom of diffeomorphism invariance by means of a scalar coordinatization. We stress the condition that the coordinatization must be made with scalars. As an example of our method for obtaining observables we d...

  2. AN APOLOGY OF THE LITERARY CANON IN A LINGUISTIC STUDY

    Directory of Open Access Journals (Sweden)

    Alexey Vladimirovich Sosnin

    2015-01-01

    Full Text Available The article highlights the principles of selecting practical material for a linguistic study aspiring to objectivity and states that in such a study orientation to the literary text is absolutely essential, as a solid corpus of literary texts is indispensable for describing complicated linguistic phenomena and mental structures standing behind them. The article puts forward the postulate that any serious study into the English language should be constructed on the English literary canon – a global textual corpus on the basis of which the greatest part of the educated speakers’ conceptual sphere is formed. At the same time, the article considers certain problems related to the Anglicist’s orientation towards the canon – its definition, limits, central and peripheral authors, the criteria of a literary work canonic status, arguments of those opposing any canonicity in literature, reconstruction of the canon in other cultures. The article also analyzes the cognitive aspect and tells about the key transformation of the English mentality, which gave rise to thinking in the terms of the time, cause-and-effect, and probability in canonic literature. The author of the article comes up with a principal conclusion: orientation to the literary canon in a linguistic study allows reconciling of linguistics and literature studies and including into the analysis nonlinguistic semiotic systems as well as idiolectal systems of conceptualizing the world in literary works.

  3. Using Canonical Forms for Isomorphism Reduction in Graph-based Model Checking

    NARCIS (Netherlands)

    Kant, Gijs

    2010-01-01

    Graph isomorphism checking can be used in graph-based model checking to achieve symmetry reduction. Instead of one-to-one comparing the graph representations of states, canonical forms of state graphs can be computed. These canonical forms can be used to store and compare states. However, computing

  4. Canonical Approaches to Applications of the Virial Theorem.

    Science.gov (United States)

    Walton, Jay R; Rivera-Rivera, Luis A; Lucchese, Robert R; Bevan, John W

    2016-02-11

    Canonical approaches are applied for investigation of the extraordinarily accurate electronic ground state potentials of H2(+), H2, HeH(+), and LiH using the virial theorem. These approaches will be dependent on previous investigations involving the canonical nature of E(R), the Born-Oppenheimer potential, and F(R), the associated force of E(R), that have been demonstrated to be individually canonical to high accuracy in the case of the systems investigated. Now, the canonical nature of the remaining functions in the virial theorem [the electronic kinetic energy T(R), the electrostatic potential energy V(R), and the function W(R) = RF(R)] are investigated and applied to H2, HeH(+), and LiH with H2(+) chosen as reference. The results will be discussed in the context of a different perspective of molecular bonding that goes beyond previous direct applications of the virial theorem.

  5. Periodicity, the Canon and Sport

    Directory of Open Access Journals (Sweden)

    Thomas F. Scanlon

    2015-10-01

    Full Text Available The topic according to this title is admittedly a broad one, embracing two very general concepts of time and of the cultural valuation of artistic products. Both phenomena are, in the present view, largely constructed by their contemporary cultures, and given authority to a great extent from the prestige of the past. The antiquity of tradition brings with it a certain cachet. Even though there may be peripheral debates in any given society which question the specifics of periodization or canonicity, individuals generally accept the consensus designation of a sequence of historical periods and they accept a list of highly valued artistic works as canonical or authoritative. We will first examine some of the processes of periodization and of canon-formation, after which we will discuss some specific examples of how these processes have worked in the sport of two ancient cultures, namely Greece and Mesoamerica.

  6. Spin Foams and Canonical Quantization

    CERN Document Server

    Alexandrov, Sergei; Noui, Karim

    2011-01-01

    This review is devoted to the analysis of the mutual consistency of the spin foam and canonical loop quantizations in three and four spacetime dimensions. In the three-dimensional context, where the two approaches are in good agreement, we show how the canonical quantization \\`a la Witten of Riemannian gravity with a positive cosmological constant is related to the Turaev-Viro spin foam model, and how the Ponzano-Regge amplitudes are related to the physical scalar product of Riemannian loop quantum gravity without cosmological constant. In the four-dimensional case, we recall a Lorentz-covariant formulation of loop quantum gravity using projected spin networks, compare it with the new spin foam models, and identify interesting relations and their pitfalls. Finally, we discuss the properties which a spin foam model is expected to possess in order to be consistent with the canonical quantization, and suggest a new model illustrating these results.

  7. Thermodynamic extension of density-functional theory. I. Canonical Massieu-Planck function, its Legendre and Massieu-Planck transforms for equilibrium state in terms of density matrix

    CERN Document Server

    Balawender, Robert

    2009-01-01

    A unified formulation of the equilibrium state of a many-electron system in terms of an ensemble (mixed-state) density matrix, which applies the maximum entropy principle combined with the use of Massieu-Planck function, is presented. The properties of the characteristic functionals for macrocanonical ensemble are established. Their extension to other ensembles is accomplished via a Legendre transform. The relations between equilibrium states defined by a formal mathematical procedure and by criteria adopted for traditional (Gibbs, Helmholtz) potentials are investigated using Massieu-Planck transform. The preeminence of the Massieu-Planck function over the traditional thermodynamic potentials is discussed in detail on an example of their second derivatives. Introduced functions are suitable for application to the extensions of the density functional theory, both at finite and zero temperatures.

  8. Resistant multiple sparse canonical correlation.

    Science.gov (United States)

    Coleman, Jacob; Replogle, Joseph; Chandler, Gabriel; Hardin, Johanna

    2016-04-01

    Canonical correlation analysis (CCA) is a multivariate technique that takes two datasets and forms the most highly correlated possible pairs of linear combinations between them. Each subsequent pair of linear combinations is orthogonal to the preceding pair, meaning that new information is gleaned from each pair. By looking at the magnitude of coefficient values, we can find out which variables can be grouped together, thus better understanding multiple interactions that are otherwise difficult to compute or grasp intuitively. CCA appears to have quite powerful applications to high-throughput data, as we can use it to discover, for example, relationships between gene expression and gene copy number variation. One of the biggest problems of CCA is that the number of variables (often upwards of 10,000) makes biological interpretation of linear combinations nearly impossible. To limit variable output, we have employed a method known as sparse canonical correlation analysis (SCCA), while adding estimation which is resistant to extreme observations or other types of deviant data. In this paper, we have demonstrated the success of resistant estimation in variable selection using SCCA. Additionally, we have used SCCA to find multiple canonical pairs for extended knowledge about the datasets at hand. Again, using resistant estimators provided more accurate estimates than standard estimators in the multiple canonical correlation setting. R code is available and documented at https://github.com/hardin47/rmscca.

  9. Romanticism, Sexuality, and the Canon.

    Science.gov (United States)

    Rowe, Kathleen K.

    1990-01-01

    Traces the Romanticism in the work and persona of film director Jean-Luc Godard. Examines the contradictions posed by Godard's politics and representations of sexuality. Asserts, that by bringing an ironic distance to the works of such canonized directors, viewers can take pleasure in those works despite their contradictions. (MM)

  10. 15N and 1H Solid-State NMR Investigation of a Canonical Low-Barrier Hydrogen-Bond Compound: 1,8-bis(dimethylamino) naphthalene

    OpenAIRE

    White, Paul B.; Hong, Mei

    2015-01-01

    Strong or low-barrier hydrogen bonds have been often proposed in proteins to explain enzyme catalysis and proton transfer reactions. So far 1H chemical shifts and scalar couplings have been used as the main NMR spectroscopic signatures for strong H-bonds. In this work, we report simultaneous measurements of 15N and 1H chemical shifts and N-H bond lengths by solid-state NMR in 15N-labeled 1,8-bis(dimethylamino) naphthalene (DMAN), which contains a well known strong NHN H-bond. We complexed DMA...

  11. Canonical transforms, quantumness and probability representation of quantum mechanics

    CERN Document Server

    Man'ko, Margarita A

    2011-01-01

    The linear canonical transforms of position and momentum are used to construct the tomographic probability representation of quantum states where the fair probability distribution determines the quantum state instead of the wave function or density matrix. The example of Moshinsky shutter problem is considered.

  12. The Transport of Relative Canonical Helicity

    CERN Document Server

    You, Setthivoine

    2012-01-01

    The evolution of relative canonical helicity is examined in the two-fluid magnetohydrodynamic formalism. Canonical helicity is defined here as the helicity of the plasma species' canonical momentum. The species' canonical helicity are coupled together and can be converted from one into the other while the total gauge-invariant relative canonical helicity remains globally invariant. The conversion is driven by enthalpy differences at a surface common to ion and electron canonical flux tubes. The model provides an explanation for why the threshold for bifurcation in counter-helicity merging depends on the size parameter. The size parameter determines whether magnetic helicity annihilation channels enthalpy into the magnetic flux tube or into the vorticity flow tube components of the canonical flux tube. The transport of relative canonical helicity constrains the interaction between plasma flows and magnetic fields, and provides a more general framework for driving flows and currents from enthalpy or inductive b...

  13. Titchmarsh-Weyl theory for canonical systems

    Directory of Open Access Journals (Sweden)

    Keshav Raj Acharya

    2014-11-01

    Full Text Available The main purpose of this paper is to develop Titchmarsh- Weyl theory of canonical systems. To this end, we first observe the fact that Schrodinger and Jacobi equations can be written into canonical systems. We then discuss the theory of Weyl m-function for canonical systems and establish the relation between the Weyl m-functions of Schrodinger equations and that of canonical systems which involve Schrodinger equations.

  14. Modern Canonical Quantum General Relativity

    Science.gov (United States)

    Thiemann, Thomas

    2008-11-01

    Preface; Notation and conventions; Introduction; Part I. Classical Foundations, Interpretation and the Canonical Quantisation Programme: 1. Classical Hamiltonian formulation of general relativity; 2. The problem of time, locality and the interpretation of quantum mechanics; 3. The programme of canonical quantisation; 4. The new canonical variables of Ashtekar for general relativity; Part II. Foundations of Modern Canonical Quantum General Relativity: 5. Introduction; 6. Step I: the holonomy-flux algebra [P]; 7. Step II: quantum-algebra; 8. Step III: representation theory of [A]; 9. Step IV: 1. Implementation and solution of the kinematical constraints; 10. Step V: 2. Implementation and solution of the Hamiltonian constraint; 11. Step VI: semiclassical analysis; Part III. Physical Applications: 12. Extension to standard matter; 13. Kinematical geometrical operators; 14. Spin foam models; 15. Quantum black hole physics; 16. Applications to particle physics and quantum cosmology; 17. Loop quantum gravity phenomenology; Part IV. Mathematical Tools and their Connection to Physics: 18. Tools from general topology; 19. Differential, Riemannian, symplectic and complex geometry; 20. Semianalytical category; 21. Elements of fibre bundle theory; 22. Holonomies on non-trivial fibre bundles; 23. Geometric quantisation; 24. The Dirac algorithm for field theories with constraints; 25. Tools from measure theory; 26. Elementary introduction to Gel'fand theory for Abelean C* algebras; 27. Bohr compactification of the real line; 28. Operatir -algebras and spectral theorem; 29. Refined algebraic quantisation (RAQ) and direct integral decomposition (DID); 30. Basics of harmonic analysis on compact Lie groups; 31. Spin network functions for SU(2); 32. + Functional analytical description of classical connection dynamics; Bibliography; Index.

  15. Derivation of Mayer Series from Canonical Ensemble

    Science.gov (United States)

    Wang, Xian-Zhi

    2016-02-01

    Mayer derived the Mayer series from both the canonical ensemble and the grand canonical ensemble by use of the cluster expansion method. In 2002, we conjectured a recursion formula of the canonical partition function of a fluid (X.Z. Wang, Phys. Rev. E 66 (2002) 056102). In this paper we give a proof for this formula by developing an appropriate expansion of the integrand of the canonical partition function. We further derive the Mayer series solely from the canonical ensemble by use of this recursion formula.

  16. Face hallucination using orthogonal canonical correlation analysis

    Science.gov (United States)

    Zhou, Huiling; Lam, Kin-Man

    2016-05-01

    A two-step face-hallucination framework is proposed to reconstruct a high-resolution (HR) version of a face from an input low-resolution (LR) face, based on learning from LR-HR example face pairs using orthogonal canonical correlation analysis (orthogonal CCA) and linear mapping. In the proposed algorithm, face images are first represented using principal component analysis (PCA). Canonical correlation analysis (CCA) with the orthogonality property is then employed, to maximize the correlation between the PCA coefficients of the LR and the HR face pairs to improve the hallucination performance. The original CCA does not own the orthogonality property, which is crucial for information reconstruction. We propose using orthogonal CCA, which is proven by experiments to achieve a better performance in terms of global face reconstruction. In addition, in the residual-compensation process, a linear-mapping method is proposed to include both the inter- and intrainformation about manifolds of different resolutions. Compared with other state-of-the-art approaches, the proposed framework can achieve a comparable, or even better, performance in terms of global face reconstruction and the visual quality of face hallucination. Experiments on images with various parameter settings and blurring distortions show that the proposed approach is robust and has great potential for real-world applications.

  17. Observables in classical canonical gravity: Folklore demystified

    Science.gov (United States)

    Pons, J. M.; Salisbury, D. C.; Sundermeyer, K. A.

    2010-04-01

    We give an overview of some conceptual difficulties, sometimes called paradoxes, that have puzzled for years the physical interpetation of classical canonical gravity and, by extension, the canonical formulation of generally covariant theories. We identify these difficulties as stemming form some terminological misunderstandings as to what is meant by "gauge invariance", or what is understood classically by a "physical state". We make a thorough analysis of the issue and show that all purported paradoxes disappear when the right terminology is in place. Since this issue is connected with the search of observables - gauge invariant quantities - for these theories, we formally show that time evolving observables can be constructed for every observer. This construction relies on the fixation of the gauge freedom of diffeomorphism invariance by means of a scalar coordinatization. We stress the condition that the coordinatization must be made with scalars. As an example of our method for obtaining observables we discuss the case of the massive particle in AdS spacetime.

  18. Observables in classical canonical gravity: Folklore demystified

    Energy Technology Data Exchange (ETDEWEB)

    Pons, J M [Departament d' Estructura i Constituents de la Materia and Institut de Ciencies del Cosmos, Universitat de Barcelona, Diagonal 647, 08028 Barcelona, Catalonia (Spain); Salisbury, D C [Department of Physics, Austin College, Sherman, Texas 75090-4440, USA, and Max-Planck-Institut fuer Wissenschaftsgeschichte, Boltzmannstrasse 22, 14195 Berlin (Germany); Sundermeyer, K A, E-mail: pons@ecm.ub.e, E-mail: dsalisbury@austincollege.ed, E-mail: ksun@gmx.d [Freie Universitaet Berlin, Fachbereich Physik, Institute for Theoretical Physics, Arnimallee 14, 14195 Berlin (Germany)

    2010-04-01

    We give an overview of some conceptual difficulties, sometimes called paradoxes, that have puzzled for years the physical interpetation of classical canonical gravity and, by extension, the canonical formulation of generally covariant theories. We identify these difficulties as stemming form some terminological misunderstandings as to what is meant by 'gauge invariance', or what is understood classically by a 'physical state'. We make a thorough analysis of the issue and show that all purported paradoxes disappear when the right terminology is in place. Since this issue is connected with the search of observables - gauge invariant quantities - for these theories, we formally show that time evolving observables can be constructed for every observer. This construction relies on the fixation of the gauge freedom of diffeomorphism invariance by means of a scalar coordinatization. We stress the condition that the coordinatization must be made with scalars. As an example of our method for obtaining observables we discuss the case of the massive particle in AdS spacetime.

  19. Canonical metrics on complex manifold

    Institute of Scientific and Technical Information of China (English)

    YAU Shing-Tung

    2008-01-01

    @@ Complex manifolds are topological spaces that are covered by coordinate charts where the Coordinate changes are given by holomorphic transformations. For example, Riemann surfaces are one dimensional complex manifolds. In order to understand complex manifolds, it is useful to introduce metrics that are compatible with the complex structure. In general, we should have a pair (M, ds2M) where ds2M is the metric. The metric is said to be canonical if any biholomorphisms of the complex manifolds are automatically isometries. Such metrics can naturally be used to describe invariants of the complex structures of the manifold.

  20. Canonical metrics on complex manifold

    Institute of Scientific and Technical Information of China (English)

    YAU; Shing-Tung(Yau; S.-T.)

    2008-01-01

    Complex manifolds are topological spaces that are covered by coordinate charts where the coordinate changes are given by holomorphic transformations.For example,Riemann surfaces are one dimensional complex manifolds.In order to understand complex manifolds,it is useful to introduce metrics that are compatible with the complex structure.In general,we should have a pair(M,ds~2_M)where ds~2_M is the metric.The metric is said to be canonical if any biholomorphisms of the complex manifolds are automatically isometries.Such metrics can naturally be used to describe invariants of the complex structures of the manifold.

  1. Grand canonical Molecular Dynamics Simulations

    CERN Document Server

    Fritsch, S; Junghans, C; Ciccotti, G; Site, L Delle; Kremer, K

    2011-01-01

    For simulation studies of (macro-) molecular liquids it would be of significant interest to be able to adjust/increase the level of resolution within one region of space, while allowing for the free exchange of molecules between (open) regions of different resolution/representation. In the present work we generalize the adaptive resolution idea in terms of a generalized Grand Canonical approach. This provides a robust framework for truly open Molecular Dynamics systems. We apply the method to liquid water at ambient conditions.

  2. What is "Relativistic Canonical Quantization"?

    OpenAIRE

    Arbatsky, D. A.

    2005-01-01

    The purpose of this review is to give the most popular description of the scheme of quantization of relativistic fields that was named relativistic canonical quantization (RCQ). I do not give here the full exact account of this scheme. But with the help of this review any physicist, even not a specialist in the relativistic quantum theory, will be able to get a general view of the content of RCQ, of its connection with other known approaches, of its novelty and of its fruitfulness.

  3. Canonical and alternative MAPK signaling.

    Science.gov (United States)

    Pimienta, Genaro; Pascual, Jaime

    2007-11-01

    The archetype of MAPK cascade activation is somewhat challenged by the most recent discovery of unexpected phosphorylation patterns, alternative activation mechanisms and sub-cellular localization, in various members of this protein kinase family. In particular, activation by autophosphorylation pathways has now been described for the three best understood MAPK subgroups: ERK1/2; JNK1/2 and p38 alpha/beta. Also, a form of dosage compensation between homologs has been shown to occur in the case of ERK1/2 and JNK1/2. In this paper we summarize the MAPK activation pathway, with an emphasis on non-canonical examples. We use this information to propose a model for MAPK signal transduction that considers a cross-talk between MAPKs with different activation loop sequence motifs and unique C-terminal extensions. We highlight the occurrence of non-canonical substrate specificity during MAPK auto-activation, in strong connection with MAPK homo- and hetero-dimerization events.

  4. The Deuteron as a Canonically Quantized Biskyrmion

    CERN Document Server

    Acus, A; Norvaisas, E; Riska, D O

    2003-01-01

    The ground state configurations of the solution to Skyrme's topological soliton model for systems with baryon number larger than 1 are well approximated with rational map ans"atze, without individual baryon coordinates. Here canonical quantization of the baryon number 2 system, which represents the deuteron, is carried out in the rational map approximation. The solution, which is described by the 6 parameters of the chiral group SU(2)$times$SU(2), is stabilized by the quantum corrections. The matter density of the variational quantized solution has the required exponential large distance falloff and the quantum numbers of the deuteron. Similarly to the axially symmetric semiclassical solution, the radius and the quadrupole moment are, however, only about half as large as the corresponding empirical values. The quantized deuteron solution is constructed for representations of arbitrary dimension of the chiral group.

  5. Process modelling on a canonical basis[Process modelling; Canonical modelling

    Energy Technology Data Exchange (ETDEWEB)

    Siepmann, Volker

    2006-12-20

    Based on an equation oriented solving strategy, this thesis investigates a new approach to process modelling. Homogeneous thermodynamic state functions represent consistent mathematical models of thermodynamic properties. Such state functions of solely extensive canonical state variables are the basis of this work, as they are natural objective functions in optimisation nodes to calculate thermodynamic equilibrium regarding phase-interaction and chemical reactions. Analytical state function derivatives are utilised within the solution process as well as interpreted as physical properties. By this approach, only a limited range of imaginable process constraints are considered, namely linear balance equations of state variables. A second-order update of source contributions to these balance equations is obtained by an additional constitutive equation system. These equations are general dependent on state variables and first-order sensitivities, and cover therefore practically all potential process constraints. Symbolic computation technology efficiently provides sparsity and derivative information of active equations to avoid performance problems regarding robustness and computational effort. A benefit of detaching the constitutive equation system is that the structure of the main equation system remains unaffected by these constraints, and a priori information allows to implement an efficient solving strategy and a concise error diagnosis. A tailor-made linear algebra library handles the sparse recursive block structures efficiently. The optimisation principle for single modules of thermodynamic equilibrium is extended to host entire process models. State variables of different modules interact through balance equations, representing material flows from one module to the other. To account for reusability and encapsulation of process module details, modular process modelling is supported by a recursive module structure. The second-order solving algorithm makes it

  6. Self-consistent thermodynamics for the Tsallis statistics in the grand canonical ensemble: Nonrelativistic hadron gas

    Energy Technology Data Exchange (ETDEWEB)

    Parvan, A.S. [Joint Institute for Nuclear Research, Bogoliubov Laboratory of Theoretical Physics, Dubna (Russian Federation); Horia Hulubei National Institute of Physics and Nuclear Engineering, Department of Theoretical Physics, Bucharest (Romania); Moldova Academy of Sciences, Institute of Applied Physics, Chisinau (Moldova, Republic of)

    2015-09-15

    In the present paper, the Tsallis statistics in the grand canonical ensemble was reconsidered in a general form. The thermodynamic properties of the nonrelativistic ideal gas of hadrons in the grand canonical ensemble was studied numerically and analytically in a finite volume and the thermodynamic limit. It was proved that the Tsallis statistics in the grand canonical ensemble satisfies the requirements of the equilibrium thermodynamics in the thermodynamic limit if the thermodynamic potential is a homogeneous function of the first order with respect to the extensive variables of state of the system and the entropic variable z = 1/(q - 1) is an extensive variable of state. The equivalence of canonical, microcanonical and grand canonical ensembles for the nonrelativistic ideal gas of hadrons was demonstrated. (orig.)

  7. Canonical curves with low apolarity

    CERN Document Server

    Ballico, Edoardo; Notari, Roberto

    2010-01-01

    Let $k$ be an algebraically closed field and let $C$ be a non--hyperelliptic smooth projective curve of genus $g$ defined over $k$. Since the canonical model of $C$ is arithmetically Gorenstein, Macaulay's theory of inverse systems allows to associate to $C$ a cubic form $f$ in the divided power $k$--algebra $R$ in $g-2$ variables. The apolarity of $C$ is the minimal number $t$ of linear form in $R$ needed to write $f$ as sum of their divided power cubes. It is easy to see that the apolarity of $C$ is at least $g-2$ and P. De Poi and F. Zucconi classified curves with apolarity $g-2$ when $k$ is the complex field. In this paper, we give a complete, characteristic free, classification of curves $C$ with apolarity $g-1$ (and $g-2$).

  8. The Psalter in the Canon

    Directory of Open Access Journals (Sweden)

    Knud Jeppesen

    2003-11-01

    Full Text Available The Psalter, read as a coherent book instead of being read as 150 independent poems, reveals some patterns and a continuum of ideas, which might not express the editors’ original intention, but support the readers’ understanding of this canonical book. The article suggests that, even if the majority of texts are laments, the Psalter is a book of praise, underlined for instance by the endings of the Psalter’s five books. The five books relate the Psalter to the Pentateuch, and a form of competition between David and Moses is found (see esp Book 4, of which David was the winner. This is one of the reasons why the Christians were able to read the Psalter as a Christian book.

  9. Revisiting Interpretation of Canonical Correlation Analysis: A Tutorial and Demonstration of Canonical Commonality Analysis

    Science.gov (United States)

    Nimon, Kim; Henson, Robin K.; Gates, Michael S.

    2010-01-01

    In the face of multicollinearity, researchers face challenges interpreting canonical correlation analysis (CCA) results. Although standardized function and structure coefficients provide insight into the canonical variates produced, they fall short when researchers want to fully report canonical effects. This article revisits the interpretation of…

  10. CANONICAL EXTENSIONS OF SYMMETRIC LINEAR RELATIONS

    NARCIS (Netherlands)

    Sandovici, Adrian; Davidson, KR; Gaspar, D; Stratila, S; Timotin, D; Vasilescu, FH

    2006-01-01

    The concept of canonical extension of Hermitian operators has been recently introduced by A. Kuzhel. This paper deals with a generalization of this notion to the case of symmetric linear relations. Namely, canonical regular extensions of symmetric linear relations in Hilbert spaces are studied. The

  11. De canon : een oude katholieke kerkstructuur?

    NARCIS (Netherlands)

    Smit, P.B.A.

    2011-01-01

    Op 30 november 2011 houdt theoloog prof. dr. Peter-Ben Smit zijn oratie aan de Universiteit Utrecht. Daarin gaat hij na hoe de canon van het Nieuwe Testament tot stand kwam binnen de vroege kerk, en wat de functie van de canon was bij de uitleg - oftewel exegese - van de Schrift. Dit onderwerp kwam

  12. The Current Canon in British Romantics Studies.

    Science.gov (United States)

    Linkin, Harriet Kramer

    1991-01-01

    Describes and reports on a survey of 164 U.S. universities to ascertain what is taught as the current canon of British Romantic literature. Asserts that the canon may now include Mary Shelley with the former standard six major male Romantic poets, indicating a significant emergence of a feminist perspective on British Romanticism in the classroom.…

  13. Subsets of configurations and canonical partition functions

    DEFF Research Database (Denmark)

    Bloch, J.; Bruckmann, F.; Kieburg, M.;

    2013-01-01

    We explain the physical nature of the subset solution to the sign problem in chiral random matrix theory: the subset sum over configurations is shown to project out the canonical determinant with zero quark charge from a given configuration. As the grand canonical chiral random matrix partition...

  14. Canonical structure of 2D black holes

    CERN Document Server

    Navarro-Salas, J; Talavera, C F

    1994-01-01

    We determine the canonical structure of two-dimensional black-hole solutions arising in $2D$ dilaton gravity. By choosing the Cauchy surface appropriately we find that the canonically conjugate variable to the black hole mass is given by the difference of local (Schwarzschild) time translations at right and left spatial infinities. This can be regarded as a generalization of Birkhoff's theorem.

  15. Canon, Jubilees 23 and Psalm 90

    Directory of Open Access Journals (Sweden)

    Pieter M. Venter

    2014-02-01

    Full Text Available There never existed only one form of the biblical canon. This can be seen in the versions as well as editions of the Hebrew and Greek Bibles. History and circumstances played a central role in the gradual growth of eventually different forms of the biblical canon. This process can be studied using the discipline of intertextuality. There always was a movement from traditum to traditio in the growth of these variant forms of biblical canon. This can be seen in an analysis of the intertextuality in Jubilees 23:8–32. The available canon of the day was interpreted there, not according to a specific demarcated volume of canonical scriptures, but in line with the theology presented in those materials, especially that of Psalm 90.

  16. Multiplicity fluctuations in heavy-ion collisions using canonical and grand-canonical ensemble

    Energy Technology Data Exchange (ETDEWEB)

    Garg, P. [Indian Institute of Technology Indore, Discipline of Physics, School of Basic Science, Simrol (India); Mishra, D.K.; Netrakanti, P.K.; Mohanty, A.K. [Bhabha Atomic Research Center, Nuclear Physics Division, Mumbai (India)

    2016-02-15

    We report the higher-order cumulants and their ratios for baryon, charge and strangeness multiplicity in canonical and grand-canonical ensembles in ideal thermal model including all the resonances. When the number of conserved quanta is small, an explicit treatment of these conserved charges is required, which leads to a canonical description of the system and the fluctuations are significantly different from the grand-canonical ensemble. Cumulant ratios of total-charge and net-charge multiplicity as a function of collision energies are also compared in grand-canonical ensemble. (orig.)

  17. Canonical Noncommutativity Algebra for the Tetrad Field in General Relativity

    CERN Document Server

    Kober, Martin

    2011-01-01

    General relativity under the assumption of noncommuting components of the tetrad field is considered in this paper. Since the algebraic properties of the tetrad field representing the gravitational field are assumed to correspond to the noncommutativity algebra of the coordinates in the canonical case of noncommutative geometry, this idea is closely related to noncommutative geometry as well as to canonical quantization of gravity. According to this presupposition there are derived generalized field equations for general relativity which are obtained by replacing the usual tetrad field by the tetrad field operator within the actions and then building expectation values of the corresponding field equations between coherent states. These coherent states refer to creation and annihilation operators created from the components of the tetrad field operator. In this sense the obtained theory could be regarded as a kind of semiclassical approximation of a complete quantum description of gravity. The consideration pr...

  18. The canonical form of the Rabi hamiltonian

    CERN Document Server

    Szopa, M; Ceulemans, A; Szopa, Marek; Mys, Geert; Ceulemans, Arnout

    1996-01-01

    The Rabi Hamiltonian, describing the coupling of a two-level system to a single quantized boson mode, is studied in the Bargmann-Fock representation. The corresponding system of differential equations is transformed into a canonical form in which all regular singularities between zero and infinity have been removed. The canonical or Birkhoff-transformed equations give rise to a two-dimensional eigenvalue problem, involving the energy and a transformational parameter which affects the coupling strength. The known isolated exact solutions of the Rabi Hamiltonian are found to correspond to the uncoupled form of the canonical system.

  19. Comparison of canonical and microcanonical definitions of entropy

    Science.gov (United States)

    Matty, Michael; Lancaster, Lachlan; Griffin, William; Swendsen, Robert H.

    2017-02-01

    For more than 100 years, one of the central concepts in statistical mechanics has been the microcanonical ensemble, which provides a way of calculating the thermodynamic entropy for a specified energy. A controversy has recently emerged between two distinct definitions of the entropy based on the microcanonical ensemble: (1) The Boltzmann entropy, defined by the density of states at a specified energy, and (2) The Gibbs entropy, defined by the sum or integral of the density of states below a specified energy. A critical difference between the consequences of these definitions pertains to the concept of negative temperatures, which by the Gibbs definition cannot exist. In this paper, we call into question the fundamental assumption that the microcanonical ensemble should be used to define the entropy. We base our analysis on a recently proposed canonical definition of the entropy as a function of energy. We investigate the predictions of the Boltzmann, Gibbs, and canonical definitions for a variety of classical and quantum models. Our results support the validity of the concept of negative temperature, but not for all models with a decreasing density of states. We find that only the canonical entropy consistently predicts the correct thermodynamic properties, while microcanonical definitions of entropy, including those of Boltzmann and Gibbs, are correct only for a limited set of models. For models which exhibit a first-order phase transition, we show that the use of the thermodynamic limit, as usually interpreted, can conceal the essential physics.

  20. Canonical equations of Hamilton with beautiful symmetry

    CERN Document Server

    Liang, Guo

    2012-01-01

    The Hamiltonian formulation plays the essential role in constructing the framework of modern physics. In this paper, a new form of canonical equations of Hamilton with the complete symmetry is obtained, which are valid not only for the first-order differential system, but also for the second-order differential system. The conventional form of the canonical equations without the symmetry [Goldstein et al., Classical Mechanics, 3rd ed, Addison-Wesley, 2001] are only for the second-order differential system. It is pointed out for the first time that the number of the canonical equations for the first-order differential system is half of that for the second-order differential system. The nonlinear Schr\\"{o}dinger equation, a universal first-order differential system, can be expressed with the new canonical equations in a consistent way.

  1. Regularized canonical correlation analysis with unlabeled data

    Institute of Scientific and Technical Information of China (English)

    Xi-chuan ZHOU; Hai-bin SHEN

    2009-01-01

    In standard canonical correlation analysis (CCA), the data from definite datasets are used to estimate their canonical correlation. In real applications, for example in bilingual text retrieval, it may have a great portion of data that we do not know which set it belongs to. This part of data is called unlabeled data, while the rest from definite datasets is called labeled data. We propose a novel method called regularized canonical correlation analysis (RCCA), which makes use of both labeled and unlabeled samples. Specifically, we learn to approximate canonical correlation as if all data were labeled. Then. we describe a generalization of RCCA for the multi-set situation. Experiments on four real world datasets, Yeast, Cloud, Iris, and Haberman, demonstrate that,by incorporating the unlabeled data points, the accuracy of correlation coefficients can be improved by over 30%.

  2. An $OSp$ extension of Canonical Tensor Model

    CERN Document Server

    Narain, Gaurav

    2015-01-01

    Tensor models are generalizations of matrix models, and are studied as discrete models of quantum gravity for arbitrary dimensions. Among them, the canonical tensor model (CTM for short) is a rank-three tensor model formulated as a totally constrained system with a number of first-class constraints, which have a similar algebraic structure as the constraints of the ADM formalism of general relativity. In this paper, we formulate a super-extension of CTM as an attempt to incorporate fermionic degrees of freedom. The kinematical symmetry group is extended from $O(N)$ to $OSp(N,\\tilde N)$, and the constraints are constructed so that they form a first-class constraint super-Poisson algebra. This is a straightforward super-extension, and the constraints and their algebraic structure are formally unchanged from the purely bosonic case, except for the additional signs associated to the order of the fermionic indices and dynamical variables. However, this extension of CTM leads to the existence of negative norm state...

  3. Canonical equations of Hamilton with beautiful symmetry

    OpenAIRE

    Liang, Guo; Guo, Qi

    2012-01-01

    The Hamiltonian formulation plays the essential role in constructing the framework of modern physics. In this paper, a new form of canonical equations of Hamilton with the complete symmetry is obtained, which are valid not only for the first-order differential system, but also for the second-order differential system. The conventional form of the canonical equations without the symmetry [Goldstein et al., Classical Mechanics, 3rd ed, Addison-Wesley, 2001] are only for the second-order differe...

  4. Investigating the Dynamics of Canonical Flux Tubes

    Science.gov (United States)

    von der Linden, Jens; Sears, Jason; Intrator, Thomas; You, Setthivoine

    2016-10-01

    Canonical flux tubes are flux tubes of the circulation of a species' canonical momentum. They provide a convenient generalization of magnetic flux tubes to regimes beyond magnetohydrodynamics (MHD). We hypothesize that hierarchies of instabilities which couple disparate scales could transfer magnetic pitch into helical flows and vice versa while conserving the total canonical helicity. This work first explores the possibility of a sausage instability existing on top of a kink as mechanism for coupling scales, then presents the evolution of canonical helicity in a gyrating kinked flux rope. Analytical and numerical stability spaces derived for magnetic flux tubes with core and skin currents indicate that, as a flux tube lengthens and collimates, it may become kink unstable with a sausage instability developing on top of the kink. A new analysis of 3D magnetic field and ion flow data on gyrating kinked magnetic flux ropes from the Reconnection Scaling Experiment tracks the evolution of canonical flux tubes and their helicity. These results and methodology are being developed as part of the Mochi experiment specifically designed to observe the dynamics of canonical flux tubes. This work is supported by DOE Grant DE-SC0010340 and the DOE Office of Science Graduate Student Research Program and prepared in part by LLNL under Contract DE-AC52-07NA27344. LLNL-ABS-697161.

  5. Both canonical and non-canonical Wnt signaling independently promote stem cell growth in mammospheres.

    Directory of Open Access Journals (Sweden)

    Alexander M Many

    Full Text Available The characterization of mammary stem cells, and signals that regulate their behavior, is of central importance in understanding developmental changes in the mammary gland and possibly for targeting stem-like cells in breast cancer. The canonical Wnt/β-catenin pathway is a signaling mechanism associated with maintenance of self-renewing stem cells in many tissues, including mammary epithelium, and can be oncogenic when deregulated. Wnt1 and Wnt3a are examples of ligands that activate the canonical pathway. Other Wnt ligands, such as Wnt5a, typically signal via non-canonical, β-catenin-independent, pathways that in some cases can antagonize canonical signaling. Since the role of non-canonical Wnt signaling in stem cell regulation is not well characterized, we set out to investigate this using mammosphere formation assays that reflect and quantify stem cell properties. Ex vivo mammosphere cultures were established from both wild-type and Wnt1 transgenic mice and were analyzed in response to manipulation of both canonical and non-canonical Wnt signaling. An increased level of mammosphere formation was observed in cultures derived from MMTV-Wnt1 versus wild-type animals, and this was blocked by treatment with Dkk1, a selective inhibitor of canonical Wnt signaling. Consistent with this, we found that a single dose of recombinant Wnt3a was sufficient to increase mammosphere formation in wild-type cultures. Surprisingly, we found that Wnt5a also increased mammosphere formation in these assays. We confirmed that this was not caused by an increase in canonical Wnt/β-catenin signaling but was instead mediated by non-canonical Wnt signals requiring the receptor tyrosine kinase Ror2 and activity of the Jun N-terminal kinase, JNK. We conclude that both canonical and non-canonical Wnt signals have positive effects promoting stem cell activity in mammosphere assays and that they do so via independent signaling mechanisms.

  6. The dark sector from interacting canonical and non-canonical scalar fields

    Energy Technology Data Exchange (ETDEWEB)

    De Souza, Rudinei C; Kremer, Gilberto M, E-mail: kremer@Fisica.ufpr.b [Departamento de Fisica, Universidade Federal do Parana, Curitiba (Brazil)

    2010-09-07

    In this work general models with interactions between two canonical scalar fields and between one non-canonical (tachyon type) and one canonical scalar field are investigated. The potentials and couplings to the gravity are selected through the Noether symmetry approach. These general models are employed to describe interactions between dark energy and dark matter, with the fields being constrained by the astronomical data. The cosmological solutions of some cases are compared with the observed evolution of the late Universe.

  7. Dark Sector from Interacting Canonical and Non-Canonical Scalar Fields

    CERN Document Server

    de Souza, Rudinei C

    2010-01-01

    In this work it is investigated general models with interactions between two canonical scalar fields and between one non-canonical (tachyon-type) and one canonical scalar field. The potentials and couplings to the gravity are selected through the Noether symmetry approach. These general models are employed to describe interactions between dark energy and dark matter, with the fields being constrained by the astronomical data. The cosmological solutions of some cases are compared with the observed evolution of the late Universe.

  8. Towards a conceptual history of canonization in totalitarian societies

    DEFF Research Database (Denmark)

    Postoutenko, Kirill

    2016-01-01

    . Roosevelt unprecedented media exposure). It turns out that Stalin’s discursive canonization has multiple reasons including his reliance on rigid radial networks of power and communication (as opposed to rotation of political and social roles in democracies), his interactional detachment from listeners and......Although totalitarian societies, by and large, have uneasy relationships with religion, they tend to produce their own “Messiahs” (people whose knowledge of the future is free from all kinds of uncertainty) and “Bibles” (texts containing explanations for each and every context imaginable...... a reference to his slogans and speeches. The article compares such a canonization in Soviet Union with parallel processes in Nazi Germany (where Adolf Hitler and his texts are revered to a much lesser degree) and United States of America (where this development is missing altogether despite Franklin D...

  9. BOOK REVIEW: Modern Canonical Quantum General Relativity

    Science.gov (United States)

    Kiefer, Claus

    2008-06-01

    the geometrical nature of gravity, no such background exists in quantum gravity. Instead, the notion of a background is supposed to emerge a posteriori as an approximate notion from quantum states of geometry. As a consequence, the standard ultraviolet divergences of quantum field theory do not show up because there is no limit of Δx → 0 to be taken in a given spacetime. On the other hand, it is open whether the theory is free of any type of divergences and anomalies. A central feature of any canonical approach, independent of the choice of variables, is the existence of constraints. In geometrodynamics, these are the Hamiltonian and diffeomorphism constraints. They also hold in loop quantum gravity, but are supplemented there by the Gauss constraint, which emerges due to the use of triads in the formalism. These constraints capture all the physics of the quantum theory because no spacetime is present anymore (analogous to the absence of trajectories in quantum mechanics), so no additional equations of motion are needed. This book presents a careful and comprehensive discussion of these constraints. In particular, the constraint algebra is calculated in a transparent and explicit way. The author makes the important assumption that a Hilbert-space structure is still needed on the fundamental level of quantum gravity. In ordinary quantum theory, such a structure is needed for the probability interpretation, in particular for the conservation of probability with respect to external time. It is thus interesting to see how far this concept can be extrapolated into the timeless realm of quantum gravity. On the kinematical level, that is, before the constraints are imposed, an essentially unique Hilbert space can be constructed in terms of spin-network states. Potentially problematic features are the implementation of the diffeomorphism and Hamiltonian constraints. The Hilbert space Hdiff defined on the diffeomorphism subspace can throw states out of the kinematical

  10. Sl$_{q}$(2) realizations for Kepler and oscillator potentials and q-canonical transformations

    CERN Document Server

    Dayi, O F; Dayi, O F; Duru, I H

    1994-01-01

    The realizations of the Lie algebra corresponding to the dynamical symmetry group SO(2,1) of the Kepler and oscillator potentials are q-deformed. The q-canonical transformation connecting two realizations is given and a general definition for q-canonical transformation is deduced. q-Schr\\"{o}dinger equation for a Kepler like potential is obtained from the q-oscillator Schr\\"{o}dinger equation. Energy spectrum and the ground state wave function are calculated.

  11. Agonistic and antagonistic roles for TNIK and MINK in non-canonical and canonical Wnt signalling.

    Directory of Open Access Journals (Sweden)

    Alexander Mikryukov

    Full Text Available Wnt signalling is a key regulatory factor in animal development and homeostasis and plays an important role in the establishment and progression of cancer. Wnt signals are predominantly transduced via the Frizzled family of serpentine receptors to two distinct pathways, the canonical ß-catenin pathway and a non-canonical pathway controlling planar cell polarity and convergent extension. Interference between these pathways is an important determinant of cellular and phenotypic responses, but is poorly understood. Here we show that TNIK (Traf2 and Nck-interacting kinase and MINK (Misshapen/NIKs-related kinase MAP4K signalling kinases are integral components of both canonical and non-canonical pathways in Xenopus. xTNIK and xMINK interact and are proteolytically cleaved in vivo to generate Kinase domain fragments that are active in signal transduction, and Citron-NIK-Homology (CNH Domain fragments that are suppressive. The catalytic activity of the Kinase domain fragments of both xTNIK and xMINK mediate non-canonical signalling. However, while the Kinase domain fragments of xTNIK also mediate canonical signalling, the analogous fragments derived from xMINK strongly antagonize this signalling. Our data suggest that the proteolytic cleavage of xTNIK and xMINK determines their respective activities and is an important factor in controlling the balance between canonical and non-canonical Wnt signalling in vivo.

  12. Concept maps and canonical models in neuropsychiatry.

    Science.gov (United States)

    Marin-Sanguino, A; del Rosario, R C H; Mendoza, E R

    2009-05-01

    Most bioscientists engage in informal modelling in their research and explicitly document this activity's results in diagrams or "concept maps". While canonical modelling approaches such as Biochemical Systems Theory (BST) immediately allow the construction of a corresponding system of equations, the problem of determining appropriate parameter values remains. Goel et al. introduced Concept Map Modelling (CMM) as a framework to address this problem through an interactive dialogue between experimenters and modellers. The CMM dialogue extracts the experimenters' implicit knowledge about dynamical behaviour of the parts of the system being modelled in form of rough sketches and verbal statements, e.g. value ranges. These are then used as inputs for parameter and initial value estimates for the symbolic canonical model based on the diagram. Canonical models have the big advantage that a great variety of parameter estimation methods have been developed for them in recent years. The paper discusses the suitability of this approach for neuropsychiatry using recent work of Qi et al. on a canonical model of presynaptic dopamine metabolism. Due to the complexity of systems encountered in neuropsychiatry, hybrid models are often used to complement the canonical models discussed here.

  13. Chondrules: The canonical and noncanonical views

    Science.gov (United States)

    Connolly, Harold C.; Jones, Rhian H.

    2016-10-01

    Millimeter-scale rock particles called chondrules are the principal components of the most common meteorites, chondrites. Hence, chondrules were arguably the most abundant components of the early solar system at the time of planetesimal accretion. Despite their fundamental importance, the existence of chondrules would not be predicted from current observations and models of young planetary systems. There are many different models for chondrule formation, but no single model satisfies the many constraints determined from their mineralogical and chemical properties and from chondrule analog experiments. Significant recent progress has shown that several models can satisfy first-order constraints and successfully reproduce chondrule thermal histories. However, second- and third-order constraints such as chondrule size ranges, open system behavior, oxidation states, reheating, and chemical diversity have not generally been addressed. Chondrule formation models include those based on processes that are known to occur in protoplanetary disk environments, including interactions with the early active Sun, impacts and collisions between planetary bodies, and radiative heating. Other models for chondrule heating mechanisms are based on hypothetical processes that are possible but have not been observed, like shock waves, planetesimal bow shocks, and lightning. We examine the evidence for the canonical view of chondrule formation, in which chondrules were free-floating particles in the protoplanetary disk, and the noncanonical view, in which chondrules were the by-products of planetesimal formation. The fundamental difference between these approaches has a bearing on the importance of chondrules during planet formation and the relevance of chondrules to interpreting the evolution of protoplanetary disks and planetary systems.

  14. Universal canonical entropy for gravitating systems

    Indian Academy of Sciences (India)

    Ashok Chatterjee; Parthasarathi Majumdar

    2004-10-01

    The thermodynamics of general relativistic systems with boundary, obeying a Hamiltonian constraint in the bulk, is determined solely by the boundary quantum dynamics, and hence by the area spectrum. Assuming, for large area of the boundary, (a) an area spectrum as determined by non-perturbative canonical quantum general relativity (NCQGR), (b) an energy spectrum that bears a power law relation to the area spectrum, (c) an area law for the leading order microcanonical entropy, leading thermal fluctuation corrections to the canonical entropy are shown to be logarithmic in area with a universal coefficient. Since the microcanonical entropy also has universal logarithmic corrections to the area law (from quantum space-time fluctuations, as found earlier) the canonical entropy then has a universal form including logarithmic corrections to the area law. This form is shown to be independent of the index appearing in assumption (b). The index, however, is crucial in ascertaining the domain of validity of our approach based on thermal equilibrium.

  15. Global canonical symmetry in a quantum system

    Institute of Scientific and Technical Information of China (English)

    李子平

    1996-01-01

    Based on the phase-space path integral for a system with a regular or singular Lagrangian the generalized canonical Ward identities under the global symmetry transformation in extended phase space are deduced respectively, thus the relations among Green functions can be found. The connection between canonical symmetries and conservation laws at the quantum level is established. It is pointed out that this connection in classical theories, in general, is no longer always preserved in quantum theories. The advantage of our formulation is that we do not need to carry out the integration over the canonical momenta in phase-space generating functional as usually performed. A precise discussion of quantization for a nonlinear sigma model with Hopf and Chern-Simons terms is reexamined. The property of fractional spin at quantum level has been clarified.

  16. Jordan Canonical Form Theory and Practice

    CERN Document Server

    Weintraub, Steven H

    2009-01-01

    Jordan Canonical Form (JCF) is one of the most important, and useful, concepts in linear algebra. The JCF of a linear transformation, or of a matrix, encodes all of the structural information about that linear transformation, or matrix. This book is a careful development of JCF. After beginning with background material, we introduce Jordan Canonical Form and related notions: eigenvalues, (generalized) eigenvectors, and the characteristic and minimum polynomials. We decide the question of diagonalizability, and prove the Cayley-Hamilton theorem. Then we present a careful and complete proof of t

  17. Dispersion Operators Algebra and Linear Canonical Transformations

    Science.gov (United States)

    Andriambololona, Raoelina; Ranaivoson, Ravo Tokiniaina; Hasimbola Damo Emile, Randriamisy; Rakotoson, Hanitriarivo

    2017-02-01

    This work intends to present a study on relations between a Lie algebra called dispersion operators algebra, linear canonical transformation and a phase space representation of quantum mechanics that we have introduced and studied in previous works. The paper begins with a brief recall of our previous works followed by the description of the dispersion operators algebra which is performed in the framework of the phase space representation. Then, linear canonical transformations are introduced and linked with this algebra. A multidimensional generalization of the obtained results is given.

  18. Canonical Transform Method for Treating Strongly Anisotropy Magnets

    DEFF Research Database (Denmark)

    Cooke, J. F.; Lindgård, Per-Anker

    1977-01-01

    An infinite-order perturbation approach to the theory of magnetism in magnets with strong single-ion anisotropy is given. This approach is based on a canonical transformation of the system into one with a diagonal crystal field, an effective two-ion anisotropy, and reduced ground-state corrections....... A matrix-element matching procedure is used to obtain an explicit expression for the spin-wave energy to second order. The consequences of this theory are illustrated by an application to a simple example with planar anisotropy and an external magnetic field. A detailed comparison between the results...

  19. Canonical conjugated Dirac equation in a curved space

    CERN Document Server

    Dzhunushaliev, Vladimir

    2012-01-01

    It is shown that the calculation of Dirac operator for the spherical coordinate system with spherical Dirac matrices and using the spin connection formalism is in the contradiction with the definition of standard Dirac operator in the spherical Minkowski coordinate system. It is shown that such contradiction one can avoid by introducing a canonical conjugated covariant derivative for the spinor field. The Dirac equation solution on the Reissner - Nordstr\\"om background is obtained. The solution describes a bound state of a charged particle.

  20. Canonical Ensemble Model for Black Hole Radiation

    Indian Academy of Sciences (India)

    Jingyi Zhang

    2014-09-01

    In this paper, a canonical ensemble model for the black hole quantum tunnelling radiation is introduced. In this model the probability distribution function corresponding to the emission shell is calculated to second order. The formula of pressure and internal energy of the thermal system is modified, and the fundamental equation of thermodynamics is also discussed.

  1. Canonical equivalence between massive spin 1 theories

    CERN Document Server

    Arias, P J; Arias, Pio J.; Perez-Mosquera, Jean C.

    2004-01-01

    The model of Cremmer-Scherck and Proca are considered in dimensions greater than 3+1. It is obtained that the Proca model correspond to a gauged fixed version of the Cremmer-Scherck one, and we show their canonical equivalence.

  2. Generalized canonical correlation analysis with missing values

    NARCIS (Netherlands)

    M. van de Velden (Michel); Y. Takane

    2009-01-01

    textabstractTwo new methods for dealing with missing values in generalized canonical correlation analysis are introduced. The first approach, which does not require iterations, is a generalization of the Test Equating method available for principal component analysis. In the second approach, missing

  3. Canonical transformation method in classical electrodynamics

    Science.gov (United States)

    Pavlenko, Yu. G.

    1983-08-01

    The solutions of Maxwell's equations in the parabolic equation approximation is obtained on the basis of the canonical transformation method. The Hamiltonian form of the equations for the field in an anisotropic stratified medium is also examined. The perturbation theory for the calculation of the wave reflection and transmission coefficients is developed.

  4. Scalar potentials out of canonical quantum cosmology

    CERN Document Server

    Guzman, W; Socorro, J; Urena-Lopez, L A

    2005-01-01

    Using canonical quantization of a flat FRW cosmological model containing a real scalar field $\\phi$ endowed with a scalar potential $V(\\phi)$, we are able to obtain exact and semiclassical solutions of the so called Wheeler-DeWitt equation for a particular family of scalar potentials. Some features of the solutions and their classical limit are discussed.

  5. Canonical analysis based on mutual information

    DEFF Research Database (Denmark)

    Nielsen, Allan Aasbjerg; Vestergaard, Jacob Schack

    2015-01-01

    combinations with the information theoretical measure mutual information (MI). We term this type of analysis canonical information analysis (CIA). MI allows for the actual joint distribution of the variables involved and not just second order statistics. While CCA is ideal for Gaussian data, CIA facilitates...

  6. Regularized Multiple-Set Canonical Correlation Analysis

    Science.gov (United States)

    Takane, Yoshio; Hwang, Heungsun; Abdi, Herve

    2008-01-01

    Multiple-set canonical correlation analysis (Generalized CANO or GCANO for short) is an important technique because it subsumes a number of interesting multivariate data analysis techniques as special cases. More recently, it has also been recognized as an important technique for integrating information from multiple sources. In this paper, we…

  7. Infants' Recognition of Objects Using Canonical Color

    Science.gov (United States)

    Kimura, Atsushi; Wada, Yuji; Yang, Jiale; Otsuka, Yumiko; Dan, Ippeita; Masuda, Tomohiro; Kanazawa, So; Yamaguchi, Masami K.

    2010-01-01

    We explored infants' ability to recognize the canonical colors of daily objects, including two color-specific objects (human face and fruit) and a non-color-specific object (flower), by using a preferential looking technique. A total of 58 infants between 5 and 8 months of age were tested with a stimulus composed of two color pictures of an object…

  8. Canonical duties, liabilities of trustees and administrators.

    Science.gov (United States)

    Morrisey, F G

    1985-06-01

    The new Code of Canon Law outlines a number of duties of those who have responsibility for administering the Church's temporal goods. Before assuming office, administrators must pledge to be efficient and faithful, and they must prepare an inventory of goods belonging to the juridic person they serve. Among their duties, administrators must: Ensure that adequate insurance is provided; Use civilly valid methods to protect canonical ownership of the goods; Observe civil and canon law prescriptions as well as donors' intentions; Collect and safeguard revenues, repay debts, and invest funds securely; Maintain accurate records, keep documents secure, and prepare an annual budget; Prepare an annual report and present it to the Ordinary where prescribed; Observe civil law concerning labor and social policy, and pay employees a just and decent wage. Administrators who carry out acts that are invalid canonically are liable for such acts. The juridic person is not liable, unless it derived benefit from the transaction. Liability is especially high when the sale of property is involved or when a contract is entered into without proper cannonical consent. Although Church law is relatively powerless to punish those who have been negligent, stewards, administrators, and trustees must do all they can to be truthful to the responsibility with which they have been entrusted.

  9. Probing the small distance structure of canonical

    NARCIS (Netherlands)

    t Hooft, G.

    2010-01-01

    In canonical quantum gravity, the formal functional integral includes an integration over the local conformal factor, and we propose to perform the functional integral over this factor before doing any of the other functional integrals. By construction, the resulting effective theory would be expect

  10. Kuidas Canon suureks kasvas / Andres Eilart

    Index Scriptorium Estoniae

    Eilart, Andres

    2004-01-01

    Jaapani kaamerate ja büroomasinate tootja Canon Groupi arengust, tegevusest kolmes regioonis - USA-s, Euroopas ja Aasias ning ettevõtte pikaajalise edu põhjustest - ärifilosoofiast ning ajastatud tootearendusest. Vt. samas: Firma esialgne nimi oli Kwanon; Konkurendid koonduvad

  11. Discovery of a broad iron line in the black hole candidate Swift J1753.5-0127, and the disc emission in the low/hard state revisited

    NARCIS (Netherlands)

    Hiemstra, Beike; Soleri, Paolo; Mendez, Mariano; Belloni, Tomaso; Mostafa, Reham; Wijnands, Rudy

    2009-01-01

    We analysed simultaneous archival XMM-Newton and Rossi X-ray Timing Explorer observations of the X-ray binary and black hole candidate Swift J1753.5-0127. In a previous analysis of the same data, a soft thermal component was found in the X-ray spectrum, and the presence of an accretion disc extendin

  12. Dragline roller track improvement. Volume I. Evaluation of low hardness dragline track materials in rolling contact. Final report, September 30, 1976-July 30, 1980

    Energy Technology Data Exchange (ETDEWEB)

    Dunfee, J.; Leonard, L.; Rumbarger, J.

    1980-01-01

    The Franklin Research Center (FRC), a Division of the Franklin Institute, was contracted by the Bureau of Mines to improve walking dragline roller tracks. The contract was subsequently transferred to the Department of Energy. The period from September 1977 to September 1978 covered laboratory rolling contact rig tests to evaluate typical low hardness dragline track materials. The results of this work are covered by DOE/ET/9121-1 Final Report, Volume I. The period from September 1978 to July 1980 covered field measurements of dragline roller circle loadings. The results of this work are covered by DOE/ET/9121-2 Final Report, Volume II. The laboratory rolling contact rig test results indicate that forged vacuum degassed air melt steel materials are recommended over air-melt cast materials for rollers and tracks. The steels tested exhibited good freedom from sensitivity to stress raisers like brinell marks and small holes or discontinuities (Volume I). The largest unknown in a recommended method for life testing roller tracks is the condition of the upper rotating frame structure and the lower tub supporting structure.

  13. Canonical Nonlinear Viscous Core Solution in pipe and elliptical geometry

    Science.gov (United States)

    Ozcakir, Ozge

    2016-11-01

    In an earlier paper (Ozcakir et al. (2016)), two new nonlinear traveling wave solutions were found with collapsing structure towards the center of the pipe as Reynolds number R -> ∞ , which were called Nonlinear Viscous Core (NVC) states. Asymptotic scaling arguments suggested that the NVC state collapse rate scales as R - 1 / 4 where axial, radial and azimuthal velocity perturbations from Hagen-Poiseuille flow scale as R - 1 / 2, R - 3 / 4 and R - 3 / 4 respectively, while (1 - c) = O (R - 1 / 2) where c is the traveling wave speed. The theoretical scaling results were roughly consistent with full Navier-Stokes numerical computations in the range 105 NVC states for pipes with elliptical cross-section and identify similar canonical structure in these cases. National Science Foundation NSF-DMS-1515755, EPSRC Grant EP/1037948/1.

  14. An introduction to the theory of canonical matrices

    CERN Document Server

    Turnbull, H W

    2004-01-01

    Thorough and self-contained, this penetrating study of the theory of canonical matrices presents a detailed consideration of all the theory's principal features. Topics include elementary transformations and bilinear and quadratic forms; canonical reduction of equivalent matrices; subgroups of the group of equivalent transformations; and rational and classical canonical forms. The final chapters explore several methods of canonical reduction, including those of unitary and orthogonal transformations. 1952 edition. Index. Appendix. Historical notes. Bibliographies. 275 problems.

  15. Microcanonical and canonical approach to traffic flow

    CERN Document Server

    Surda, Anton

    2007-01-01

    A system of identical cars on a single-lane road is treated as a microcanonical and canonical ensemble. Behaviour of the cars is characterized by the probability of car velocity as a function of distance and velocity of the car ahead. The calculations a performed on a discrete 1D lattice with discrete car velocities. Probability of total velocity of a group of cars as a function of density is calculated in microcanonical approach. For a canonical ensemble, fluctuations of car density as a function of total velocity is found. Phase transitions between free and jammed flow for large deceleration rate of cars and formation of queues of cars with the same velocity for low deceleration rate are described.

  16. Canonical Quantum Gravity on Noncommutative Spacetime

    CERN Document Server

    Kober, Martin

    2014-01-01

    In this paper canonical quantum gravity on noncommutative space-time is considered. The corresponding generalized classical theory is formulated by using the moyal star product, which enables the representation of the field quantities depending on noncommuting coordinates by generalized quantities depending on usual coordinates. But not only the classical theory has to be generalized in analogy to other field theories. Besides, the necessity arises to replace the commutator between the gravitational field operator and its canonical conjugated quantity by a corresponding generalized expression on noncommutative space-time. Accordingly the transition to the quantum theory has also to be performed in a generalized way and leads to extended representations of the quantum theoretical operators. If the generalized representations of the operators are inserted to the generalized constraints, one obtains the corresponding generalized quantum constraints including the Hamiltonian constraint as dynamical constraint. Af...

  17. Deformed Special Relativity in a Canonical Framework

    CERN Document Server

    Ghosh, S; Ghosh, Subir; Pal, Probir

    2007-01-01

    In this paper we have studied the nature of kinematical and dynamical laws in $\\kappa $-Minkowski spacetime from a new perspective: the canonical phase space approach. We have introduced a new form of $\\kappa$-Minkowski phase space algebra from which we recover the $\\kappa$-extended finite Lorentz transformations derived in \\cite{kim}. This is a particular form of a Deformed Special Relativity model that admits a modified energy-momentum dispersion law as well as noncommutative $\\kappa$-Minkowski phase space. We show that this system can be completely mapped to a set of phase space variables that obey canonical (and {\\it{not}} $\\kappa$-Minkowski) phase space algebra and Special Relativity Lorentz transformation (and {\\it{not}} $\\kappa$-extended Lorentz transformation). We demonstrate the usefulness and simplicity of this approach through a number of applications both in classical and quantum mechanics. We also construct a Lagrangian for the $\\kappa$-particle.

  18. Non-canonical modulators of nuclear receptors.

    Science.gov (United States)

    Tice, Colin M; Zheng, Ya-Jun

    2016-09-01

    Like G protein-coupled receptors (GPCRs) and protein kinases, nuclear receptors (NRs) are a rich source of pharmaceutical targets. Over 80 NR-targeting drugs have been approved for 18 NRs. The focus of drug discovery in NRs has hitherto been on identifying ligands that bind to the canonical ligand binding pockets of the C-terminal ligand binding domains (LBDs). Due to the development of drug resistance and selectivity concerns, there has been considerable interest in exploring other, non-canonical ligand binding sites. Unfortunately, the potencies of compounds binding at other sites have generally not been sufficient for clinical development. However, the situation has changed dramatically over the last 3years, as compounds with sufficient potency have been reported for several NR targets. Here we review recent developments in this area from a medicinal chemistry point of view in the hope of stimulating further interest in this area of research.

  19. Baby Skyrmions stabilized by canonical quantization

    Energy Technology Data Exchange (ETDEWEB)

    Acus, A.; Norvaisas, E. [Vilnius University, Institute of Theoretical Physics and Astronomy, Gostauto 12, Vilnius 01108 (Lithuania); Shnir, Ya., E-mail: shnir@maths.tcd.i [School of Theoretical Physics - DIAS, 10 Burlington Road, Dublin 4 (Ireland); Institute of Physics, Jagiellonian University, Krakow (Poland)

    2009-11-23

    We analyse the effect of the canonical quantization of the rotational mode of the O(3)sigma-model which includes the Skyrme term. Numerical evidence is presented that the quantum correction to the mass of the rotationally-invariant charge n=1,2 configurations may stabilize the solution even in the limit of vanishing potential. The corresponding range of values of the parameters is discussed.

  20. Baby Skyrmions stabilized by canonical quantization

    CERN Document Server

    Acus, A; Shnir, Ya

    2009-01-01

    We analyse the effect of the canonical quantization of the rotational mode of the O(3) $\\sigma$-model which includes the Skyrme term. Numerical evidence is presented that the quantum correction to the mass of the rotationally-invariant charge $n=1,2$ configurations may stabilize the solution even in the limit of vanishing potential. The corresponding range of values of the parameters is discussed.

  1. Cluster expansion in the canonical ensemble

    CERN Document Server

    Pulvirenti, Elena

    2011-01-01

    We consider a system of particles confined in a box $\\La\\subset\\R^d$ interacting via a tempered and stable pair potential. We prove the validity of the cluster expansion for the canonical partition function in the high temperature - low density regime. The convergence is uniform in the volume and in the thermodynamic limit it reproduces Mayer's virial expansion providing an alternative and more direct derivation which avoids the deep combinatorial issues present in the original proof.

  2. On Complex Supermanifolds with Trivial Canonical Bundle

    CERN Document Server

    Groeger, Josua

    2016-01-01

    We give an algebraic characterisation for the triviality of the canonical bundle of a complex supermanifold in terms of a certain Batalin-Vilkovisky superalgebra structure. As an application, we study the Calabi-Yau case, in which an explicit formula in terms of the Levi-Civita connection is achieved. Our methods include the use of complex integral forms and the recently developed theory of superholonomy.

  3. CANONICAL FORMULATION OF NONHOLONOMIC CONSTRAINED SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    GUO YONG-XIN; YU YING; HUANG HAI-JUN

    2001-01-01

    Based on the Ehresmann connection theory and symplectic geometry, the canonical formulation of nonholonomic constrained mechanical systems is described. Following the Lagrangian formulation of the constrained system, the Hamiltonian formulation is given by Legendre transformation. The Poisson bracket defined by an anti-symmetric tensor does not satisfy the Jacobi identity for the nonintegrability of nonholonomic constraints. The constraint manifold can admit symplectic submanifold for some cases, in which the Lie algebraic structure exists.

  4. Il Canone Linguistico Boccacciano, Non Senza Dissenso

    Directory of Open Access Journals (Sweden)

    Cecilia Casini

    2015-06-01

    Full Text Available Author of prose’s greatest masterpiece of medieval literature in the vernacular, Giovanni Boccaccio was crucial to defining the Italian language canon, especially since Pietro Bembo proposed its coding in the sixteenth century. Not without controversy, however, since shortly after the publication of Prose Della Volgar Language, Bembo presents the first contrasting theories that support the linguistic model presented by Machiavelli

  5. Canonical approach to 2D induced gravity

    CERN Document Server

    Popovic, D

    2001-01-01

    Using canonical method the Liouville theory has been obtained as a gravitational Wess-Zumino action of the Polyakov string. From this approach it is clear that the form of the Liouville action is the consequence of the bosonic representation of the Virasoro algebra, and that the coefficient in front of the action is proportional to the central charge and measures the quantum braking of the classical symmetry.

  6. Canonical Sets of Best L1-Approximation

    Directory of Open Access Journals (Sweden)

    Dimiter Dryanov

    2012-01-01

    Full Text Available In mathematics, the term approximation usually means either interpolation on a point set or approximation with respect to a given distance. There is a concept, which joins the two approaches together, and this is the concept of characterization of the best approximants via interpolation. It turns out that for some large classes of functions the best approximants with respect to a certain distance can be constructed by interpolation on a point set that does not depend on the choice of the function to be approximated. Such point sets are called canonical sets of best approximation. The present paper summarizes results on canonical sets of best L1-approximation with emphasis on multivariate interpolation and best L1-approximation by blending functions. The best L1-approximants are characterized as transfinite interpolants on canonical sets. The notion of a Haar-Chebyshev system in the multivariate case is discussed also. In this context, it is shown that some multivariate interpolation spaces share properties of univariate Haar-Chebyshev systems. We study also the problem of best one-sided multivariate L1-approximation by sums of univariate functions. Explicit constructions of best one-sided L1-approximants give rise to well-known and new inequalities.

  7. Point Canonical Transformation for Solving Five-Parameter Exponential-Type Potential

    Institute of Scientific and Technical Information of China (English)

    YANGJin; XIANGAn-Ping; YUWan-Lun

    2003-01-01

    Using the approach of mapping of shape invariant potentials under point canonical transformations, the energy spectra and wave functions are most easily determined for the bound states of the five-parameter exponential-type potential with a little extra effort.

  8. System Identification and Filtering of Nonlinear Controlled Markov Processes by Canonical Variate Analysis

    Science.gov (United States)

    1989-10-30

    In this Phase I SBIR study, new methods are developed for the system identification and stochastic filtering of nonlinear controlled Markov processes...state space Markov process models and canonical variate analysis (CVA) for obtaining optimal nonlinear procedures for system identification and stochastic

  9. Canonical group quantization and boundary conditions

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Florian

    2012-07-16

    In the present thesis, we study quantization of classical systems with non-trivial phase spaces using the group-theoretical quantization technique proposed by Isham. Our main goal is a better understanding of global and topological aspects of quantum theory. In practice, the group-theoretical approach enables direct quantization of systems subject to constraints and boundary conditions in a natural and physically transparent manner -- cases for which the canonical quantization method of Dirac fails. First, we provide a clarification of the quantization formalism. In contrast to prior treatments, we introduce a sharp distinction between the two group structures that are involved and explain their physical meaning. The benefit is a consistent and conceptually much clearer construction of the Canonical Group. In particular, we shed light upon the 'pathological' case for which the Canonical Group must be defined via a central Lie algebra extension and emphasise the role of the central extension in general. In addition, we study direct quantization of a particle restricted to a half-line with 'hard wall' boundary condition. Despite the apparent simplicity of this example, we show that a naive quantization attempt based on the cotangent bundle over the half-line as classical phase space leads to an incomplete quantum theory; the reflection which is a characteristic aspect of the 'hard wall' is not reproduced. Instead, we propose a different phase space that realises the necessary boundary condition as a topological feature and demonstrate that quantization yields a suitable quantum theory for the half-line model. The insights gained in the present special case improve our understanding of the relation between classical and quantum theory and illustrate how contact interactions may be incorporated.

  10. Canonical energy and linear stability of Schwarzschild

    Science.gov (United States)

    Prabhu, Kartik; Wald, Robert

    2017-01-01

    Consider linearised perturbations of the Schwarzschild black hole in 4 dimensions. Using the linearised Newman-Penrose curvature component, which satisfies the Teukolsky equation, as a Hertz potential we generate a `new' metric perturbation satisfying the linearised Einstein equation. We show that the canonical energy, given by Hollands and Wald, of the `new' metric perturbation is the conserved Regge-Wheeler-like energy used by Dafermos, Holzegel and Rodnianski to prove linear stability and decay of perturbations of Schwarzschild. We comment on a generalisation of this strategy to prove the linear stability of the Kerr black hole.

  11. Kato expansion in quantum canonical perturbation theory

    Science.gov (United States)

    Nikolaev, Andrey

    2016-06-01

    This work establishes a connection between canonical perturbation series in quantum mechanics and a Kato expansion for the resolvent of the Liouville superoperator. Our approach leads to an explicit expression for a generator of a block-diagonalizing Dyson's ordered exponential in arbitrary perturbation order. Unitary intertwining of perturbed and unperturbed averaging superprojectors allows for a description of ambiguities in the generator and block-diagonalized Hamiltonian. We compare the efficiency of the corresponding computational algorithm with the efficiencies of the Van Vleck and Magnus methods for high perturbative orders.

  12. Women and Textiles: Warping the Architectural Canon

    OpenAIRE

    Aron, Jamie

    2012-01-01

    Textiles have long been a part of the canon of Western architecture—from the folds of draped female forms in ancient Greek temples to the abstract Mayan patterns “knitted” together in Frank Lloyd Wright’s textile block houses of the 1920s. Yet just as any façade may conceal what’s inside, architecture’s shared history with weaving is often obscured. Today architecture sits at the top alongside the “fine arts” of painting and sculpture, while woven textiles occupy a less prominent position in ...

  13. Canonical formalism for coupled beam optics

    Energy Technology Data Exchange (ETDEWEB)

    Kheifets, S.A.

    1989-09-01

    Beam optics of a lattice with an inter-plane coupling is treated using canonical Hamiltonian formalism. The method developed is equally applicable both to a circular (periodic) machine and to an open transport line. A solution of the equation of a particle motion (and correspondingly transfer matrix between two arbitrary points of the lattice) are described in terms of two amplitude functions (and their derivatives and corresponding phases of oscillations) and four coupling functions, defined by a solution of the system of the first-order nonlinear differential equations derived in the paper. Thus total number of independent parameters is equal to ten. 8 refs.

  14. Kato expansion in quantum canonical perturbation theory

    CERN Document Server

    Nikolaev, A S

    2015-01-01

    This work establishes a connection between canonical perturbation series in quantum mechanics and a Kato expansion for the resolvent of the Liouville superoperator. Our approach leads to an explicit expression for a generator of a block-diagonalizing Dyson ordered exponential in arbitrary perturbation order. Unitary intertwining of perturbed and unperturbed averaging superprojectors allows for a description of ambiguities in the generator and block-diagonalized Hamiltonian. The corresponding computational algorithm is more efficient for high perturbative orders than the algorithms of Van Vleck and Magnus methods.

  15. Rate coefficients and reaction mechanism for the reaction of OH radicals with (E)-CF3CH═CHF, (Z)-CF3CH═CHF, (E)-CF3CF═CHF, and (Z)-CF3CF═CHF between 200 and 400 K: hybrid density functional theory and canonical variational transition state theory calculations.

    Science.gov (United States)

    Balaganesh, M; Rajakumar, B

    2012-10-11

    The rate coefficients of ((E)-CF(3)CH═CHF, (Z)-CF(3)CH═CHF, (E)-CF(3)CF═CHF, and (Z)-CF(3)CF═CHF) + OH reactions were computed using M06-2X/6-31+G(d,p) theory in the temperature range of 200 and 400 K. The possible reaction mechanisms of the ((E)-CF(3)CH═CHF, (Z)-CF(3)CH═CHF, (E)-CF(3)CF═CHF, and (Z)-CF(3)CF═CHF) + OH reactions were examined. The rate coefficients for the addition and abstraction reactions were calculated using canonical variational transition state theory (CVT) and conventional transition state theory (CTST), respectively, and we concluded that abstraction reactions are negligible within the temperature range and addition reactions take the lead role. The small curvature tunnelling (SCT) was included in the computation of the rate coefficients. The temperature dependent rate expressions (in cm(3) molecule(-1) s(-1)) of the (E)-CF(3)CH═CHF, (Z)-CF(3)CH═CHF, (E)-CF(3)CF═CHF, and (Z)-CF(3)CF═CHF + OH reactions between 200 and 400 K are presented. The atmospheric lifetimes and global warming potentials (GWPs) of the test molecules were computed using the rate coefficients obtained in this study, and it is concluded that these molecules are very short-lived in the Earth's atmosphere with low GWPs.

  16. Canonical Transformations can Dramatically Simplify Supersymmetry

    CERN Document Server

    Dixon, John

    2016-01-01

    A useful way to keep track of the SUSY invariance of a theory is by formulating it with a BRST Poisson Bracket. It turns out that there is a crucial subtlety that is hidden in this formulation. When the theory contains a Chiral Multiplet, the relevant BRST Poisson Bracket has a very important Canonical Transformation that leaves it invariant. This Canonical Transformation takes all or part of the Scalar Field $A$ and replaces it with a Zinn Source $J_A$, and also takes the related Zinn Source $\\Gamma_A$ and replaces it with an `Antighost' Field $\\eta_A$. Naively, this looks like it is just a change of notation. But in fact the interpretation means that one has moved some of the conserved Noether SUSY current from the Field Action, and placed it partly in the Zinn Sources Action, and so the SUSY current in the Field part of the Action is no longer conserved, because the Zinn Sources do not satisfy any equations of motion. They are not quantized, because they are Sources. So it needs to be recognized that SUSY ...

  17. Canon Fodder: Young Adult Literature as a Tool for Critiquing Canonicity

    Science.gov (United States)

    Hateley, Erica

    2013-01-01

    Young adult literature is a tool of socialisation and acculturation for young readers. This extends to endowing "reading" with particular significance in terms of what literature should be read and why. This paper considers some recent young adult fiction with an eye to its engagement with canonical literature and its representations of…

  18. Non-canonical RAN Translation of CGG Repeats Has Canonical Requirements.

    Science.gov (United States)

    Cox, Diana C; Cooper, Thomas A

    2016-04-21

    Repeat expansions cause dominantly inherited neurological disorders. In this issue of Molecular Cell, Kearse et al. (2016) examine the requirements for RAN translation of the CGG repeats that cause fragile X-associated tremor/ataxia syndrome, revealing similarities and differences with canonical translation.

  19. When Canonical Quantization Fails, Here is How to Fix It

    OpenAIRE

    Klauder, John R.

    2016-01-01

    Following Dirac, the rules of canonical quantization include classical and quantum contact transformations of classical and quantum phase space variables. While arbitrary classical canonical coordinate transformations exist that is not the case for some analogous quantum canonical coordinate transformations. This failure is due to the rigid connection of quantum variables arising by promoting the corresponding classical variable from a $c$-number to a $q$-number. A different relationship of $...

  20. Canonical symmetry properties of the constrained singular generalized mechanical system

    Institute of Scientific and Technical Information of China (English)

    李爱民; 江金环; 李子平

    2003-01-01

    Based on generalized Apell-Chetaev constraint conditions and to take the inherent constrains for singular Lagrangian into account, the generalized canonical equations for a general mechanical system with a singular higher-order Lagrangian and subsidiary constrains are formulated. The canonical symmetries in phase space for such a system are studied and Noether theorem and its inversion theorem in the generalized canonical formalism have been established.

  1. Canonical symmetry properties of the constrained singular generalized mechanical system

    Institute of Scientific and Technical Information of China (English)

    LiAi-Min; JiangJin-Huan; LiZi-Ping

    2003-01-01

    Based on generalized Apell-Chetaev constraint conditions and to take the inherent constrains for singular Lagrangian into account,the generalized canonical equations for a general mechanical system with a singular higher-order Lagrangian and subsidiary constrains are formulated. The canonical symmetries in phase space for such a system are studied and Noether theorem and its inversion theorem in the generalized canonical formalism have been established.

  2. Canonical terminal patterning is an evolutionary novelty.

    Science.gov (United States)

    Duncan, Elizabeth J; Benton, Matthew A; Dearden, Peter K

    2013-05-01

    Patterning of the terminal regions of the Drosophila embryo is achieved by an exquisitely regulated signal that passes between the follicle cells of the ovary, and the developing embryo. This pathway, however, is missing or modified in other insects. Here we trace the evolution of this pathway by examining the origins and expression of its components. The three core components of this pathway: trunk, torso and torso-like have different evolutionary histories and have been assembled step-wise to form the canonical terminal patterning pathway of Drosophila and Tribolium. Trunk, torso and a gene unrelated to terminal patterning, prothoraciotrophic hormone (PTTH), show an intimately linked evolutionary history, with every holometabolous insect, except the honeybee, possessing both PTTH and torso genes. Trunk is more restricted in its phylogenetic distribution, present only in the Diptera and Tribolium and, surprisingly, in the chelicerate Ixodes scapularis, raising the possibility that trunk and torso evolved earlier than previously thought. In Drosophila torso-like restricts the activation of the terminal patterning pathway to the poles of the embryo. Torso-like evolved in the pan-crustacean lineage, but based on expression of components of the canonical terminal patterning system in the hemimetabolous insect Acyrthosiphon pisum and the holometabolous insect Apis mellifera, we find that the canonical terminal-patterning system is not active in these insects. We therefore propose that the ancestral function of torso-like is unrelated to terminal patterning and that torso-like has become co-opted into terminal patterning in the lineage leading to Coleoptera and Diptera. We also show that this co-option has not resulted in changes to the molecular function of this protein. Torso-like from the pea aphid, honeybee and Drosophila, despite being expressed in different patterns, are functionally equivalent. We propose that co-option of torso-like into restricting the activity

  3. Update on non-canonical microRNAs

    OpenAIRE

    2014-01-01

    Non-canonical microRNAs are a recently-discovered subset of microRNAs. They structurally and functionally resemble canonical miRNAs, but were found to follow distinct maturation pathways, typically bypassing one or more steps of the classic canonical biogenesis pathway. Non-canonical miRNAs were found to have diverse origins, including introns, snoRNAs, endogenous shRNAs and tRNAs. Our knowledge about their functions remains relatively primitive; however, many interesting discoveries have tak...

  4. The Topology of Canonical Flux Tubes in Flared Jet Geometry

    Science.gov (United States)

    Sander Lavine, Eric; You, Setthivoine

    2017-01-01

    Magnetized plasma jets are generally modeled as magnetic flux tubes filled with flowing plasma governed by magnetohydrodynamics (MHD). We outline here a more fundamental approach based on flux tubes of canonical vorticity, where canonical vorticity is defined as the circulation of the species’ canonical momentum. This approach extends the concept of magnetic flux tube evolution to include the effects of finite particle momentum and enables visualization of the topology of plasma jets in regimes beyond MHD. A flared, current-carrying magnetic flux tube in an ion-electron plasma with finite ion momentum is thus equivalent to either a pair of electron and ion flow flux tubes, a pair of electron and ion canonical momentum flux tubes, or a pair of electron and ion canonical vorticity flux tubes. We examine the morphology of all these flux tubes for increasing electrical currents, different radial current profiles, different electron Mach numbers, and a fixed, flared, axisymmetric magnetic geometry. Calculations of gauge-invariant relative canonical helicities track the evolution of magnetic, cross, and kinetic helicities in the system, and show that ion flow fields can unwind to compensate for an increasing magnetic twist. The results demonstrate that including a species’ finite momentum can result in a very long collimated canonical vorticity flux tube even if the magnetic flux tube is flared. With finite momentum, particle density gradients must be normal to canonical vorticities, not to magnetic fields, so observations of collimated astrophysical jets could be images of canonical vorticity flux tubes instead of magnetic flux tubes.

  5. The Literary Canon in the Age of New Media

    DEFF Research Database (Denmark)

    Backe, Hans-Joachim

    2015-01-01

    and mediality of the canon. In a development that has largely gone unnoticed outside German speaking countries, new approaches for discussing current and future processes of canonization have been developed in recent years. One pivotal element of this process has been a thorough re-evaluation new media...... as a touchstone for both defining literature in the digital age and inquiring into the mechanisms of contemporary canon formation. The article is thus aimed at introducing both the specifically German approach to canon developed in recent years and its results to a larger scholarly community....

  6. Consistency of canonical formulation of Horava gravity

    Energy Technology Data Exchange (ETDEWEB)

    Soo, Chopin, E-mail: cpsoo@mail.ncku.edu.tw [Department of Physics, National Cheng Kung University, Tainan, Taiwan (China)

    2011-09-22

    Both the non-projectable and projectable version of Horava gravity face serious challenges. In the non-projectable version, the constraint algebra is seemingly inconsistent. The projectable version lacks a local Hamiltonian constraint, thus allowing for an extra graviton mode which can be problematic. A new formulation (based on arXiv:1007.1563) of Horava gravity which is naturally realized as a representation of the master constraint algebra (instead of the Dirac algebra) studied by loop quantum gravity researchers is presented. This formulation yields a consistent canonical theory with first class constraints; and captures the essence of Horava gravity in retaining only spatial diffeomorphisms as the physically relevant non-trivial gauge symmetry. At the same time the local Hamiltonian constraint is equivalently enforced by the master constraint.

  7. Linear canonical transforms theory and applications

    CERN Document Server

    Kutay, M; Ozaktas, Haldun; Sheridan, John

    2016-01-01

    This book provides a clear and accessible introduction to the essential mathematical foundations of linear canonical transforms from a signals and systems perspective. Substantial attention is devoted to how these transforms relate to optical systems and wave propagation. There is extensive coverage of sampling theory and fast algorithms for numerically approximating the family of transforms. Chapters on topics ranging from digital holography to speckle metrology provide a window on the wide range of applications. This volume will serve as a reference for researchers in the fields of image and signal processing, wave propagation, optical information processing and holography, optical system design and modeling, and quantum optics. It will be of use to graduate students in physics and engineering, as well as for scientists in other areas seeking to learn more about this important yet relatively unfamiliar class of integral transformations.

  8. New Canonical Variables for d=11 Supergravity

    CERN Document Server

    Melosch, S; Melosch, Stephan; Nicolai, Hermann

    1998-01-01

    A set of new canonical variables for $d=11$ supergravity is proposed which renders the supersymmetry variations and the supersymmetry constraint polynomial. The construction is based on the $SO(1,2)\\times SO(16)$ invariant reformulation of $d=11$ supergravity given in previous work, and has some similarities with Ashtekar's reformulation of Einstein's theory. The new bosonic variables fuse the gravitational degrees of freedom with those of the three-index photon $A_{MNP}$ in accordance with the hidden symmetries of the dimensionally reduced theory. Although $E_8$ is not a symmetry of the theory, the bosonic sector exhibits a remarkable $E_8$ structure, hinting at the existence of a novel type of ``exceptional geometry''.

  9. Families of Log Canonically Polarized Varieties

    CERN Document Server

    Dundon, Ariana

    2011-01-01

    Determining the number of singular fibers in a family of varieties over a curve is a generalization of Shafarevich's Conjecture and has implications for the types of subvarieties that can appear in the corresponding moduli stack. We consider families of log canonically polarized varieties over $\\P^1$, i.e. families $g:(Y,D)\\to \\P^1$ where $D$ is an effective snc divisor and the sheaf $\\omega_{Y/\\P^1}(D)$ is $g$-ample. After first defining what it means for fibers of such a family to be singular, we show that with the addition of certain mild hypotheses (the fibers have finite automorphism group, $\\sO_Y(D)$ is semi-ample, and the components of $D$ must avoid the singular locus of the fibers and intersect the fibers transversely), such a family must either be isotrivial or contain at least 3 singular fibers.

  10. Canonical Quantization of $(2+1)$ Dimensional Qed with Topological Mass Term

    CERN Document Server

    Haller, K; Haller, Kurt; Lombridas, Edwin

    1992-01-01

    We discuss the canonical quantization of Quantum Electrodynamics in $2+1$ dimensions, with a Chern-Simons topological mass term and gauge-covariant coupling to a Dirac spinor field. A gauge-fixing term is used which generates a canonical momentum for $A_0$, so that there are no primary constraints on operator-valued fields. Gauss's Law and the gauge condition, $A_0=0$, are implemented by embedding the formulation in an appropriate physical subspace, in which state vectors remain naturally, in the course of time evolution. The photon propagator is derived from the canonical theory. The electric and magnetic fields are separated into parts that reflect the presence of massive photons, and other parts that are rigidly attached to charged fermions and do not consist of any observable, propagating particle excitations. The effect of rotations on charged particle states is analyzed, and the relation between the canonical and the Belinfante ``symmetric'' angular momentum is discussed. It is shown that the rotation o...

  11. Theory of extreme correlations using canonical Fermions and path integrals

    Energy Technology Data Exchange (ETDEWEB)

    Shastry, B. Sriram, E-mail: sriram@physics.ucsc.edu

    2014-04-15

    The  t–J  model is studied using a novel and rigorous mapping of the Gutzwiller projected electrons, in terms of canonical electrons. The mapping has considerable similarity to the Dyson–Maleev transformation relating spin operators to canonical Bosons. This representation gives rise to a non Hermitian quantum theory, characterized by minimal redundancies. A path integral representation of the canonical theory is given. Using it, the salient results of the extremely correlated Fermi liquid (ECFL) theory, including the previously found Schwinger equations of motion, are easily rederived. Further, a transparent physical interpretation of the previously introduced auxiliary Greens function and the ‘caparison factor’, is obtained. The low energy electron spectral function in this theory, with a strong intrinsic asymmetry, is summarized in terms of a few expansion coefficients. These include an important emergent energy scale Δ{sub 0} that shrinks to zero on approaching the insulating state, thereby making it difficult to access the underlying very low energy Fermi liquid behavior. The scaled low frequency ECFL spectral function, related simply to the Fano line shape, has a peculiar energy dependence unlike that of a Lorentzian. The resulting energy dispersion obtained by maximization is a hybrid of a massive and a massless Dirac spectrum E{sub Q}{sup ∗}∼γQ−√(Γ{sub 0}{sup 2}+Q{sup 2}), where the vanishing of Q, a momentum type variable, locates the kink minimum. Therefore the quasiparticle velocity interpolates between (γ∓1) over a width Γ{sub 0} on the two sides of Q=0, implying a kink there that strongly resembles a prominent low energy feature seen in angle resolved photoemission spectra (ARPES) of cuprate materials. We also propose novel ways of analyzing the ARPES data to isolate the predicted asymmetry between particle and hole excitations. -- Highlights: •Spectral function of the Extremely Correlated Fermi Liquid theory at low energy.

  12. CERN Photo Club (CPC) / Canon Contest - My View of CERN

    CERN Multimedia

    Steyaert, Didier

    2016-01-01

    The CERN Photo Club has organized in collaboration with Canon Switzerland a photo contest open to all members of the CERN (Persons with a CERN access card). The only restriction is that the photos must have been taken with a CANON camera (DSLR, bridge or compact) between 1 and 31 October 2016.

  13. Iterative algorithms to approximate canonical Gabor windows: Computational aspects

    DEFF Research Database (Denmark)

    Janssen, A.J.E.M; Søndergaard, Peter Lempel

    In this paper we investigate the computational aspects of some recently proposed iterative methods for approximating the canonical tight and canonical dual window of a Gabor frame (g,a,b). The iterations start with the window g while the iteration steps comprise the window g, the k^th iterand...

  14. The Literary Canon in the Age of New Media

    DEFF Research Database (Denmark)

    Backe, Hans-Joachim

    2015-01-01

    and mediality of the canon. In a development that has largely gone unnoticed outside German speaking countries, new approaches for discussing current and future processes of canonization have been developed in recent years. One pivotal element of this process has been a thorough re-evaluation new media...

  15. Canonical connection on a class of Riemannian almost product manifolds

    CERN Document Server

    Mekerov, Dimitar

    2009-01-01

    The canonical connection on a Riemannian almost product manifolds is an analogue to the Hermitian connection on an almost Hermitian manifold. In this paper we consider the canonical connection on a class of Riemannian almost product manifolds with nonintegrable almost product structure.

  16. Critical Literature Pedagogy: Teaching Canonical Literature for Critical Literacy

    Science.gov (United States)

    Borsheim-Black, Carlin; Macaluso, Michael; Petrone, Robert

    2014-01-01

    This article introduces Critical Literature Pedagogy (CLP), a pedagogical framework for applying goals of critical literacy within the context of teaching canonical literature. Critical literacies encompass skills and dispositions to understand, question, and critique ideological messages of texts; because canonical literature is often…

  17. Three-order pseudo-Hamilton canonical equations

    Institute of Scientific and Technical Information of China (English)

    Ma Shan-Jun; Huang Pei-Tian; Yan Rong; Zhao Hong-Xia

    2006-01-01

    Based on the three-order Lagrangian equations, Hamilton's function ofacceleration H* and generalized acceleration momentum P*α are defined, and pseudo-Hamilton canonical equations corresponding to three-order Lagrangian equations are obtained. The equations are similar to Hamilton's canonical equations of analytical mechanics in form.

  18. Enabling grand-canonical Monte Carlo: extending the flexibility of GROMACS through the GromPy python interface module.

    Science.gov (United States)

    Pool, René; Heringa, Jaap; Hoefling, Martin; Schulz, Roland; Smith, Jeremy C; Feenstra, K Anton

    2012-05-01

    We report on a python interface to the GROMACS molecular simulation package, GromPy (available at https://github.com/GromPy). This application programming interface (API) uses the ctypes python module that allows function calls to shared libraries, for example, written in C. To the best of our knowledge, this is the first reported interface to the GROMACS library that uses direct library calls. GromPy can be used for extending the current GROMACS simulation and analysis modes. In this work, we demonstrate that the interface enables hybrid Monte-Carlo/molecular dynamics (MD) simulations in the grand-canonical ensemble, a simulation mode that is currently not implemented in GROMACS. For this application, the interplay between GromPy and GROMACS requires only minor modifications of the GROMACS source code, not affecting the operation, efficiency, and performance of the GROMACS applications. We validate the grand-canonical application against MD in the canonical ensemble by comparison of equations of state. The results of the grand-canonical simulations are in complete agreement with MD in the canonical ensemble. The python overhead of the grand-canonical scheme is only minimal.

  19. A Canonical Approach to the Argument/Adjunct Distinction

    Directory of Open Access Journals (Sweden)

    Diana Forker

    2014-01-01

    Full Text Available This paper provides an account of the argument/adjunct distinction implementing the 'canonical approach'. I identify five criteria (obligatoriness, latency, co-occurrence restrictions, grammatical relations, and iterability and seven diagnostic tendencies that can be used to distinguish canonical arguments from canonical adjuncts. I then apply the criteria and tendencies to data from the Nakh-Daghestanian language Hinuq. Hinuq makes extensive use of spatial cases for marking adjunct-like and argument-like NPs. By means of the criteria and tendencies it is possible to distinguish spatial NPs that come close to canonical arguments from those that are canonical adjuncts, and to place the remaining NPs bearing spatial cases within the argument-adjunct continuum.

  20. Canonical correlations between chemical and energetic characteristics of lignocellulosic wastes

    Directory of Open Access Journals (Sweden)

    Thiago de Paula Protásio

    2012-09-01

    Full Text Available Canonical correlation analysis is a statistical multivariate procedure that allows analyzing linear correlation that may exist between two groups or sets of variables (X and Y. This paper aimed to provide canonical correlation analysis between a group comprised of lignin and total extractives contents and higher heating value (HHV with a group of elemental components (carbon, hydrogen, nitrogen and sulfur for lignocellulosic wastes. The following wastes were used: eucalyptus shavings; pine shavings; red cedar shavings; sugar cane bagasse; residual bamboo cellulose pulp; coffee husk and parchment; maize harvesting wastes; and rice husk. Only the first canonical function was significant, but it presented a low canonical R². High carbon, hydrogen and sulfur contents and low nitrogen contents seem to be related to high total extractives contents of the lignocellulosic wastes. The preliminary results found in this paper indicate that the canonical correlations were not efficient to explain the correlations between the chemical elemental components and lignin contents and higher heating values.

  1. The canon as text for a biblical theology

    Directory of Open Access Journals (Sweden)

    James A. Loader

    2005-10-01

    Full Text Available The novelty of the canonical approach is questioned and its fascination at least partly traced to the Reformation, as well as to the post-Reformation’s need for a clear and authoritative canon to perform the function previously performed by the church. This does not minimise the elusiveness and deeply contradictory positions both within the canon and triggered by it. On the one hand, the canon itself is a centripetal phenomenon and does play an important role in exegesis and theology. Even so, on the other hand, it not only contains many difficulties, but also causes various additional problems of a formal as well as a theological nature. The question is mooted whether the canonical approach alleviates or aggravates the dilemma. Since this approach has become a major factor in Christian theology, aspects of the Christian canon are used to gauge whether “canon” is an appropriate category for eliminating difficulties that arise by virtue of its own existence. Problematic uses and appropriations of several Old Testament canons are advanced, as well as evidence in the New Testament of a consciousness that the “old” has been surpassed(“Überbietungsbewußtsein”. It is maintained that at least the Childs version of the canonical approach fails to smooth out these and similar difficulties. As a method it can cater for the New Testament’s (superior role as the hermeneutical standard for evaluating the Old, but flounders on its inability to create the theological unity it claims can solve religious problems exposed by Old Testament historical criticism. It is concluded that canon as a category cannot be dispensed with, but is useful for the opposite of the purpose to which it is conventionally put: far from bringing about theological “unity” or producing a standard for “correct” exegesis, it requires different readings of different canons.

  2. Ein Kanon ganz für uns allein? A Canon of Our Own?

    Directory of Open Access Journals (Sweden)

    Annette Kliewer

    2007-11-01

    Full Text Available Die Gender-Studies haben sich immer wieder damit hervorgetan, dass sie den traditionellen Kanon im Wissenschaftsbetrieb kritisierten. Nun veranstaltete das Referat Genderforschung der Universität Wien vom 28. bis 29. 11. 2005 eine internationale Tagung, bei der nach Existenz, Entwicklung und Sinn eines Kanons für die Frauen- und Geschlechterforschung selbst gefragt wurde. Mit dieser wissenschaftspolitischen Tagung wurde das Thema einer Ringvorlesung „Ein Kanon ganz für uns allein?“ (Sommersemester 2005 auf Fragen des internationalen Wissenschaftstransfers ausgedehnt. Auch in den Gender Studies gibt es Kanonisierungen, die Wissenschaftlerinnen ausschließen, vor allem aus nichtwestlichen Zusammenhängen, seien es postkoloniale oder postsozialistische Staaten. Eingeladen waren deshalb Referentinnen aus 15 verschiedenen Ländern.Gender Studies always took pride in criticizing the traditional scholarly canon. The Referat Genderforschung (Gender Research Facilities at the University of Vienna, however, hosted an international conference from November 28-29, 2005, which directly questioned themes such as the existence, development, and meaning of a canon for women’s and gender studies. A successful lecture series with the title “A Canon of Our Own” (spring 2005 and the ever-increasing demand for scholarly exchange provided the inspiration for the conference. But canonization exists in Gender Studies as well, which excludes certain female scholars, particularly those from a non-western background, whether from postcolonial or postsocialist states. To combat this, the hosts invited speakers from 15 different countries.

  3. El Escritor y las Normas del Canon Literario (The Writer and the Norms of the Literary Canon).

    Science.gov (United States)

    Policarpo, Alcibiades

    This paper speculates about whether a literary canon exists in contemporary Latin American literature, particularly in the prose genre. The paper points to Carlos Fuentes, Gabriel Garcia Marquez, and Mario Vargas Llosa as the three authors who might form this traditional and liberal canon with their works "La Muerte de Artemio Cruz"…

  4. Finite Canonical Measure for Nonsingular Cosmologies

    CERN Document Server

    Page, Don N

    2011-01-01

    The total canonical (Liouville-Henneaux-Gibbons-Hawking-Stewart) measure is finite for completely nonsingular Friedmann-Robertson-Walker classical universes with a minimally coupled massive scalar field and a positive cosmological constant. For a cosmological constant very small in units of the square of the scalar field mass, most of the measure is for nearly de Sitter solutions with no inflation at a much more rapid rate. However, if one restricts to solutions in which the scalar field energy density is ever more than twice the equivalent energy density of the cosmological constant, then the number of e-folds of rapid inflation must be large, and the fraction of the measure is low in which the spatial curvature is comparable to the cosmological constant at the time when it is comparable to the energy density of the scalar field. The measure for such classical FRW-Lambda-phi models with both a big bang and a big crunch is also finite. Only the solutions with a big bang that expand forever, or the time-revers...

  5. Canonical Coordinates for Retino-Cortical Magnification

    Directory of Open Access Journals (Sweden)

    Luc Florack

    2014-02-01

    Full Text Available A geometric model for a biologically-inspired visual front-end is proposed, based on an isotropic, scale-invariant two-form field. The model incorporates a foveal property typical of biological visual systems, with an approximately linear decrease of resolution as a function of eccentricity, and by a physical size constant that measures the radius of the geometric foveola, the central region characterized by maximal resolving power. It admits a description in singularity-free canonical coordinates generalizing the familiar log-polar coordinates and reducing to these in the asymptotic case of negligibly-sized geometric foveola or, equivalently, at peripheral locations in the visual field. It has predictive power to the extent that quantitative geometric relationships pertaining to retino-cortical magnification along the primary visual pathway, such as receptive field size distribution and spatial arrangement in retina and striate cortex, can be deduced in a principled manner. The biological plausibility of the model is demonstrated by comparison with known facts of human vision.

  6. Canonical quantum gravity in the Vassiliev invariants arena; 2, Constraints, habitats and consistency of the constraint algebra

    CERN Document Server

    Di Bartolo, C; Griego, J R; Pullin, J; Bartolo, Cayetano Di; Gambini, Rodolfo; Griego, Jorge; Pullin, Jorge

    2000-01-01

    In a companion paper we introduced a kinematical arena for the discussion of the constraints of canonical quantum gravity in the spin network representation based on Vassiliev invariants. In this paper we introduce the Hamiltonian constraint, extend the space of states to non-diffeomorphism invariant ``habitats'' and check that the off-shell quantum constraint commutator algebra reproduces the classical Poisson algebra of constraints of general relativity without anomalies. One can therefore consider the resulting set of constraints and space of states as a consistent theory of canonical quantum gravity.

  7. Exact Discrete Analogs of Canonical Commutation and Uncertainty Relations

    Directory of Open Access Journals (Sweden)

    Vasily E. Tarasov

    2016-06-01

    Full Text Available An exact discretization of the canonical commutation and corresponding uncertainty relations are suggested. We prove that the canonical commutation relations of discrete quantum mechanics, which is based on standard finite difference, holds for constant wave functions only. In this paper, we use the recently proposed exact discretization of derivatives, which is based on differences that are represented by infinite series. This new mathematical tool allows us to build sensible discrete quantum mechanics based on the suggested differences and includes the correct canonical commutation and uncertainty relations.

  8. Canonical approach to finite density QCD with multiple precision computation

    CERN Document Server

    Fukuda, Ryutaro; Oka, Shotaro

    2015-01-01

    We calculate the baryon chemical potential ($\\mu_B$) dependence of thermodynamic observables, i.e., pressure, baryon number density and susceptibility by lattice QCD using the canonical approach. We compare the results with those by the multi parameter reweighting (MPR) method; Both methods give very consistent values in the regions where errors of the MPR are under control. The canonical method gives reliable results over $\\mu_ B/T=3$,with $T$ being temperature. Multiple precision operations play an important roll in the evaluation of canonical partition functions.

  9. MBARI CANON Experiment Visualization and Analysis

    Science.gov (United States)

    Fatland, R.; Oscar, N.; Ryan, J. P.; Bellingham, J. G.

    2013-12-01

    We describe the task of understanding a marine drift experiment conducted by MBARI in Fall 2012 ('CANON'). Datasets were aggregated from a drifting ADCP, from the MBARI Environmental Sample Processor, from Long Range Autonomous Underwater Vehicles (LRAUVs), from other in situ sensors, from NASA and NOAA remote sensing platforms, from moorings, from shipboard CTD casts and from post-experiment metagenomic analysis. We seek to combine existing approaches to data synthesis -- visual inspection, cross correlation and co.-- with three new ideas. This approach has the purpose of differentiating biological signals into three causal categories: Microcurrent advection, physical factors and microbe metabolism. Respective examples are aberrance from Lagrangian frame drift due to windage, changes in solar flux over several days, and microbial population responses to shifts in nitrate concentration. The three ideas we implemented are as follows: First, we advect LRAUV data to look for patterns in time series data for conserved quanitities such as salinity. We investigate whether such patterns can be used to support or undermine the premise of Lagrangian motion of the experiment ensemble. Second we built a set of configurable filters that enable us to visually isolate segments of data: By type, value, time, anomaly and location. Third we associated data hypotheses with a Bayesian inferrence engine for the purpose of model validation, again across sections taken from within the complete data complex. The end result is towards a free-form exploration of experimental data with low latency: from question to view, from hypothesis to test (albeit with considerable preparatory effort.) Preliminary results show the three causal categories shifting in relative influence.

  10. Canonical and non-canonical barriers facing antimiR cancer therapeutics.

    Science.gov (United States)

    Cheng, Christopher J; Saltzman, W Mark; Slack, Frank J

    2013-01-01

    Once considered genetic "oddities", microRNAs (miRNAs) are now recognized as key epigenetic regulators of numerous biological processes, including some with a causal link to the pathogenesis, maintenance, and treatment of cancer. The crux of small RNA-based therapeutics lies in the antagonism of potent cellular targets; the main shortcoming of the field in general, lies in ineffective delivery. Inhibition of oncogenic miRNAs is a relatively nascent therapeutic concept, but as with predecessor RNA-based therapies, success hinges on delivery efficacy. This review will describes the canonical (e.g. pharmacokinetics and clearance, cellular uptake, endosome escape, etc.) and non-canonical (e.g. spatial localization and accessibility of miRNA, technical limitations of miRNA inhibition, off-target impacts, etc.) challenges to the delivery of antisense-based anti-miRNA therapeutics (i.e. antimiRs) for the treatment of cancer. Emphasis will be placed on how the current leading antimiR platforms-ranging from naked chemically modified oligonucleotides to nanoscale delivery vehicles-are affected by and overcome these barriers. The perplexity of antimiR delivery presents both engineering and biological hurdles that must be overcome in order to capitalize on the extensive pharmacological benefits of antagonizing tumor-associated miRNAs.

  11. Log canonical thresholds of quasi-ordinary hypersurface singularities

    CERN Document Server

    Budur, Nero; Villa, Manuel González

    2011-01-01

    The log canonical thresholds of irreducible quasi-ordinary hypersurface singularities are computed, using an explicit list of pole candidates for the motivic zeta function found by the last two authors.

  12. The Canonical Expanding Soliton and Harnack inequalities for Ricci flow

    CERN Document Server

    Cabezas-Rivas, Esther

    2009-01-01

    We introduce the notion of Canonical Expanding Ricci Soliton, and use it to derive new Harnack inequalities for Ricci flow. This viewpoint also gives geometric insight into the existing Harnack inequalities of Hamilton and Brendle.

  13. ORDERED ANALYTIC REPRESENTATION OF PDES BY HAMILTONIAN CANONICAL SYSTEM

    Institute of Scientific and Technical Information of China (English)

    ZhengYu; ChenYong

    2002-01-01

    Based on the method of symplectic geometry and variational calculation,the method for some PDEs to be ordered and analytically represented by Hamiltonian canonical system is discussed. Meanwhile some related necessary and sufficient conditions are obtained.

  14. Asymptotic distributions in the projection pursuit based canonical correlation analysis

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    In this paper, associations between two sets of random variables based on the projection pursuit (PP) method are studied. The asymptotic normal distributions of estimators of the PP based canonical correlations and weighting vectors are derived.

  15. Nitric oxide synthase: non-canonical expression patterns

    Directory of Open Access Journals (Sweden)

    Mattila eJoshua

    2014-10-01

    Full Text Available Science can move ahead by questioning established or canonical views and, so it may be with the enzymes, nitric oxide synthases (NOS. Nitric oxide (NO is generated by NOS isoforms that are often described by their tissue-specific expression patterns. NOS1 (nNOS is abundant in neural tissue, NOS2 is upregulated in activated macrophages and known as inducible NOS (iNOS, and NOS3 (eNOS is abundant in endothelium where it regulates vascular tone. These isoforms are described as constitutive or inducible, but in this Perspective we question the broad application of these labels. Are there instances where ‘constitutive’ NOS (NOS1 and NOS3 are inducibly expressed; conversely, are there instances where NOS2 is constitutively expressed? NOS1 and NOS3 inducibility may be linked to post-translational regulation, making their actual patterns activity much more difficult to detect. Constitutive NOS2 expression has been observed several tissues, especially the human pulmonary epithelium where it may regulate airway tone. These data suggest expression of the three NOS enzymes may include non-established patterns. Such information should be useful in designing strategies to modulate these important enzymes in different disease states.

  16. Canonical quantization of a string describing N branes at angles

    Science.gov (United States)

    Pesando, Igor

    2014-12-01

    We study the canonical quantization of a bosonic string in presence of N twist fields. This generalizes the quantization of the twisted string in two ways: the in and out states are not necessarily twisted and the number of twist fields N can be bigger than 2. In order to quantize the theory we need to find the normal modes. Then we need to define a product between two modes which is conserved. Because of this we need to use the Klein-Gordon product and to separate the string coordinate into the classical and the quantum part. The quantum part has different boundary conditions than the original string coordinates but these boundary conditions are precisely those which make the operator describing the equation of motion self adjoint. The splitting of the string coordinates into a classical and quantum part allows the formulation of an improved overlap principle. Using this approach we then proceed in computing the generating function for the generic correlator with L untwisted operators and N (excited) twist fields for branes at angles. We recover as expected the results previously obtained using the path integral. This construction explains why these correlators are given by a generalization of the Wick theorem.

  17. Canonical and Irish Gothic Features in Melmoth the Wanderer

    OpenAIRE

    González Rodríguez, Julia

    2016-01-01

    In the eighteenth century, a Gothic literary canon emerged. This B.A. Thesis aims to show that there is not a unique type of Gothic literary tradition. To illustrate this, a variant of the canonical Gothic, namely the Irish Gothic, is presented, with an Irish novel, Melmoth the Wanderer (1820) by Charles Robert Maturin, as an illustration of its main traits. Following an analytic method, the distinctive features of each Gothic tradition are explained separately. Then, an analysis of the major...

  18. Hojman's conservation theorems for generalized Raitzin canonical equations of motion

    Institute of Scientific and Technical Information of China (English)

    Qiao Yong-Fen; Li Ren-Jie; Zhao Shu-Hong

    2005-01-01

    Using the Lie symmetry under infinitesimal transformations in which the time is not variable, Hojman's conservation theorems for Raitzin's canonical equations of motion in generalized classical mechanics are studied. The generalized Raitzin's canonical equations of motion are established. The determining equations of Lie symmetry under infinitesimal transformations are given. The Hojman conservation theorems of the system are established. Finally, an example is also presented to illustrate the application of the result.

  19. Update on non-canonical microRNAs

    Science.gov (United States)

    Abdelfattah, Ahmed Maher; Park, Chanhyun

    2015-01-01

    Non-canonical microRNAs are a recently-discovered subset of microRNAs. They structurally and functionally resemble canonical miRNAs, but were found to follow distinct maturation pathways, typically bypassing one or more steps of the classic canonical biogenesis pathway. Non-canonical miRNAs were found to have diverse origins, including introns, snoRNAs, endogenous shRNAs and tRNAs. Our knowledge about their functions remains relatively primitive; however, many interesting discoveries have taken place in the past few years. They have been found to take part in several cellular processes, such as immune response and stem cell proliferation. Adversely, their deregulation has pathologic effects on several different tissues, which strongly suggests an integral role for non-canonical miRNAs in disease pathogenesis. In this review, we discuss the recently-discovered functional characteristics of non-canonical miRNAs and illustrate their principal maturation pathways as well as debating their potential role in multiple cellular processes. PMID:25372759

  20. The role of the Wnt canonical signaling in neurodegenerative diseases.

    Science.gov (United States)

    Libro, Rosaliana; Bramanti, Placido; Mazzon, Emanuela

    2016-08-01

    The Wnt/β-catenin or Wnt canonical pathway controls multiple biological processes throughout development and adult life. Growing evidences have suggested that deregulation of the Wnt canonical pathway could be involved in the pathogenesis of neurodegenerative diseases. The Wnt canonical signaling is a pathway tightly regulated, which activation results in the inhibition of the Glycogen Synthase Kinase 3β (GSK-3β) function and in increased β-catenin activity, that migrates into the nucleus, activating the transcription of the Wnt target genes. Conversely, when the Wnt canonical pathway is turned off, increased levels of GSK-3β promote β-catenin degradation. Hence, GSK-3β could be considered as a key regulator of the Wnt canonical pathway. Of note, GSK-3β has also been involved in the modulation of inflammation and apoptosis, determining the delicate balance between immune tolerance/inflammation and neuronal survival/neurodegeneration. In this review, we have summarized the current acknowledgements about the role of the Wnt canonical pathway in the pathogenesis of some neurodegenerative diseases including Alzheimer's disease, cerebral ischemia, Parkinson's disease, Huntington's disease, multiple sclerosis and amyotrophic lateral sclerosis, with particular regard to the main in vitro and in vivo studies in this field, by reviewing 85 research articles about.

  1. Accretion of the Moon from non-canonical discs.

    Science.gov (United States)

    Salmon, J; Canup, R M

    2014-09-13

    Impacts that leave the Earth-Moon system with a large excess in angular momentum have recently been advocated as a means of generating a protolunar disc with a composition that is nearly identical to that of the Earth's mantle. We here investigate the accretion of the Moon from discs generated by such 'non-canonical' impacts, which are typically more compact than discs produced by canonical impacts and have a higher fraction of their mass initially located inside the Roche limit. Our model predicts a similar overall accretional history for both canonical and non-canonical discs, with the Moon forming in three consecutive steps over hundreds of years. However, we find that, to yield a lunar-mass Moon, the more compact non-canonical discs must initially be more massive than implied by prior estimates, and only a few of the discs produced by impact simulations to date appear to meet this condition. Non-canonical impacts require that capture of the Moon into the evection resonance with the Sun reduced the Earth-Moon angular momentum by a factor of 2 or more. We find that the Moon's semi-major axis at the end of its accretion is approximately 7R⊕, which is comparable to the location of the evection resonance for a post-impact Earth with a 2.5 h rotation period in the absence of a disc. Thus, the dynamics of the Moon's assembly may directly affect its ability to be captured into the resonance.

  2. Accretion of the Moon from non-canonical disks

    CERN Document Server

    Salmon, Julien

    2014-01-01

    Impacts that leave the Earth-Moon system with a large excess in angular momentum have recently been advocated as a means of generating a protolunar disc with a composition that is nearly identical to that of the Earth's mantle. We here investigate the accretion of the Moon from discs generated by such "non-canonical" impacts, which are typically more compact than discs produced by canonical impacts and have a higher fraction of their mass initially located inside the Roche limit. Our model predicts a similar overall accretional history for both canonical and non-canonical discs, with the Moon forming in three consecutive steps over hundreds of years. However, we find that, to yield a lunar-mass Moon, the more compact non-canonical discs must initially be more massive than implied by prior estimates, and only a few of the discs produced by impact simulations to date appear to meet this condition. Non-canonical impacts require that capture of the Moon into the evection resonance with the Sun reduced the Earth-M...

  3. A Comparative Study of Kernel and Robust Canonical Correlation Analysis

    Directory of Open Access Journals (Sweden)

    Ashad M. Alam

    2010-02-01

    Full Text Available A number of measures of canonical correlation coefficient are now used in multimedia related fields like object recognition, image segmentation facial expression recognition and pattern recognition in the different literature. Some robust forms of classical canonical correlation coefficient are introduced recently to address the robustness issue of the canonical coefficient in the presence of outliers and departure from normality. Also a few number of kernels are used in canonical analysis to capture nonlinear relationship in data space, which is linear in some higher dimensional feature space. But not much work has been done to investigate their relative performances through i simulation from the view point of sensitivity, breakdown analysis as well as ii using real data sets. In this paper an attempt has been made to compare performances of kernel canonical correlation coefficients (Gaussian function, Laplacian function and Polynomial function with that of robust and classical canonical correlation coefficient measures using simulation with five sample sizes (50, 500, 1000, 1500 and 2000, influence function, breakdown point along with several real data and a multi-modal data sets, focusing on the specific case of segmented images with associated text. We investigate the bias, mean square error(MISE, qualitative robustness index (RI, sensitivity curve of each estimator under a variety of situations and also employ box plots and scatter plots of canonical variates to judge their performances. We have observed that the class of kernel estimators perform better than the class of classical and robust estimators in general and the kernel estimator with Laplacian function has shown the best performance for large sample size and break down is high in case of nonlinear data.

  4. Components of the canonical and non-canonical Wnt pathways are not mis-expressed in pituitary tumors.

    Directory of Open Access Journals (Sweden)

    Leandro Machado Colli

    Full Text Available INTRODUCTION: Canonical and non-canonical Wnt pathways are involved in the genesis of multiple tumors; however, their role in pituitary tumorigenesis is mostly unknown. OBJECTIVE: This study evaluated gene and protein expression of Wnt pathways in pituitary tumors and whether these expression correlate to clinical outcome. MATERIALS AND METHODS: Genes of the WNT canonical pathway: activating ligands (WNT11, WNT4, WNT5A, binding inhibitors (DKK3, sFRP1, β-catenin (CTNNB1, β-catenin degradation complex (APC, AXIN1, GSK3β, inhibitor of β-catenin degradation complex (AKT1, sequester of β-catenin (CDH1, pathway effectors (TCF7, MAPK8, NFAT5, pathway mediators (DVL-1, DVL-2, DVL-3, PRICKLE, VANGL1, target genes (MYB, MYC, WISP2, SPRY1, TP53, CCND1; calcium dependent pathway (PLCB1, CAMK2A, PRKCA, CHP; and planar cell polarity pathway (PTK7, DAAM1, RHOA were evaluated by QPCR, in 19 GH-, 18 ACTH-secreting, 21 non-secreting (NS pituitary tumors, and 5 normal pituitaries. Also, the main effectors of canonical (β-catenin, planar cell polarity (JNK, and calcium dependent (NFAT5 Wnt pathways were evaluated by immunohistochemistry. RESULTS: There are no differences in gene expression of canonical and non-canonical Wnt pathways between all studied subtypes of pituitary tumors and normal pituitaries, except for WISP2, which was over-expressed in ACTH-secreting tumors compared to normal pituitaries (4.8x; p = 0.02, NS pituitary tumors (7.7x; p = 0.004 and GH-secreting tumors (5.0x; p = 0.05. β-catenin, NFAT5 and JNK proteins showed no expression in normal pituitaries and in any of the pituitary tumor subtypes. Furthermore, no association of the studied gene or protein expression was observed with tumor size, recurrence, and progressive disease. The hierarchical clustering showed a regular pattern of genes of the canonical and non-canonical Wnt pathways randomly distributed throughout the dendrogram. CONCLUSIONS: Our data reinforce previous reports

  5. The effects of colloidal SiO2 and inhibitor on the solid deposit formation in geothermal water of low hardness

    Directory of Open Access Journals (Sweden)

    Stanković Novica J.

    2011-01-01

    Full Text Available Low solubility of SiO2 and its occurrence in geothermal waters in the form of ionic, colloidal and suspended state are the main cause of the solid deposit occurrence. Certain chemical types of silica, under the influence of Fe2+, Al3+, F−, OH- ions and other micro-constituents, and due to significantly decreased solubility of SiO2, stimulate nucleation, particle growth and solid deposit formation. The aim of this paper is to inhibit the process of nucleation and solid deposit formation by adding originally designed inhibitor in the form of an emulsion, when the total concentration of the present and added colloidal SiO2 is beyond the solubility limit (120 mg/dm3. By turbidimetric, SEM, EDS and XRD analysis, the processes of solid deposit formation were investigated in Vranjska Banja (Serbia spa geothermal water source (water hardness of 4ºdH, and theoretical and practical conclusions were made.

  6. Canonical Wnt Signaling Regulates Atrioventricular Junction Programming and Electrophysiological Properties

    Science.gov (United States)

    Gillers, Benjamin S; Chiplunkar, Aditi; Aly, Haytham; Valenta, Tomas; Basler, Konrad; Christoffels, Vincent M.; Efimov, Igor R; Boukens, Bastiaan J; Rentschler, Stacey

    2014-01-01

    Rationale Proper patterning of the atrioventricular canal (AVC) is essential for delay of electrical impulses between atria and ventricles, and defects in AVC maturation can result in congenital heart disease. Objective To determine the role of canonical Wnt signaling in the myocardium during AVC development. Methods and Results We utilized a novel allele of β-catenin that preserves β-catenin’s cell adhesive functions but disrupts canonical Wnt signaling, allowing us to probe the effects of Wnt loss of function independently. We show that loss of canonical Wnt signaling in the myocardium results in tricuspid atresia with hypoplastic right ventricle associated with loss of AVC myocardium. In contrast, ectopic activation of Wnt signaling was sufficient to induce formation of ectopic AV junction-like tissue as assessed by morphology, gene expression, and electrophysiologic criteria. Aberrant AVC development can lead to ventricular preexcitation, a characteristic feature of Wolff-Parkinson-White syndrome. We demonstrate that postnatal activation of Notch signaling downregulates canonical Wnt targets within the AV junction. Stabilization of β-catenin protein levels can rescue Notch-mediated ventricular preexcitation and dysregulated ion channel gene expression. Conclusions Our data demonstrate that myocardial canonical Wnt signaling is an important regulator of AVC maturation and electrical programming upstream of Tbx3. Our data further suggests that ventricular preexcitation may require both morphologic patterning defects, as well as myocardial lineage reprogramming, to allow robust conduction across accessory pathway tissue. PMID:25599332

  7. Variation principle of piezothermoelastic bodies, canonical equation and homogeneous equation

    Institute of Scientific and Technical Information of China (English)

    LIU Yan-hong; ZHANG Hui-ming

    2007-01-01

    Combining the symplectic variations theory, the homogeneous control equation and isoparametric element homogeneous formulations for piezothermoelastic hybrid laminates problems were deduced. Firstly, based on the generalized Hamilton variation principle, the non-homogeneous Hamilton canonical equation for piezothermoelastic bodies was derived. Then the symplectic relationship of variations in the thermal equilibrium formulations and gradient equations was considered, and the non-homogeneous canonical equation was transformed to homogeneous control equation for solving independently the coupling problem of piezothermoelastic bodies by the incensement of dimensions of the canonical equation. For the convenience of deriving Hamilton isoparametric element formulations with four nodes, one can consider the temperature gradient equation as constitutive relation and reconstruct new variation principle. The homogeneous equation simplifies greatly the solution programs which are often performed to solve nonhomogeneous equation and second order differential equation on the thermal equilibrium and gradient relationship.

  8. Canonical Entropy and Phase Transition of Rotating Black Hole

    Institute of Scientific and Technical Information of China (English)

    ZHAO Ren; WU Yue-Qin; ZHANG Li-Chun

    2008-01-01

    Recently, the Hawking radiation of a black hole has been studied using the tunnel effect method. The radiation spectrum of a black hole is derived. By discussing the correction to spectrum of the rotating black hole, we obtain the canonical entropy. The derived canonical entropy is equal to the sum of Bekenstein-Hawking entropy and correction term. The correction term near the critical point is different from the one near others. This difference plays an important role in studying the phase transition of the black hole. The black hole thermal capacity diverges at the critical point. However, the canonical entropy is not a complex number at this point. Thus we think that the phase transition created by this critical point is the second order phase transition. The discussed black hole is a five-dimensional Kerr-AdS black hole. We provide a basis for discussing thermodynamic properties of a higher-dimensional rotating black hole.

  9. Quantum canonical tensor model and an exact wave function

    CERN Document Server

    Sasakura, Naoki

    2013-01-01

    Tensor models in various forms are being studied as models of quantum gravity. Among them the canonical tensor model has a canonical pair of rank-three tensors as dynamical variables, and is a pure constraint system with first-class constraints. The Poisson algebra of the first-class constraints has structure functions, and provides an algebraically consistent way of discretizing the Dirac first-class constraint algebra for general relativity. This paper successfully formulates the Wheeler-DeWitt scheme of quantization of the canonical tensor model; the ordering of operators in the constraints is determined without ambiguity by imposing Hermiticity and covariance on the constraints, and the commutation algebra of constraints takes essentially the same from as the classical Poisson algebra, i.e. is first-class. Thus one could consistently obtain, at least locally in the configuration space, wave functions of "universe" by solving the partial differential equations representing the constraints, i.e. the Wheeler...

  10. Convolution theorems for the linear canonical transform and their applications

    Institute of Scientific and Technical Information of China (English)

    DENG Bing; TAO Ran; WANG Yue

    2006-01-01

    As generalization of the fractional Fourier transform (FRFT), the linear canonical transform (LCT) has been used in several areas, including optics and signal processing. Many properties for this transform are already known, but the convolution theorems, similar to the version of the Fourier transform, are still to be determined. In this paper, the authors derive the convolution theorems for the LCT, and explore the sampling theorem and multiplicative filter for the band limited signal in the linear canonical domain. Finally, the sampling and reconstruction formulas are deduced, together with the construction methodology for the above mentioned multiplicative filter in the time domain based on fast Fourier transform (FFT), which has much lower computational load than the construction method in the linear canonical domain.

  11. Kernel canonical-correlation Granger causality for multiple time series

    Science.gov (United States)

    Wu, Guorong; Duan, Xujun; Liao, Wei; Gao, Qing; Chen, Huafu

    2011-04-01

    Canonical-correlation analysis as a multivariate statistical technique has been applied to multivariate Granger causality analysis to infer information flow in complex systems. It shows unique appeal and great superiority over the traditional vector autoregressive method, due to the simplified procedure that detects causal interaction between multiple time series, and the avoidance of potential model estimation problems. However, it is limited to the linear case. Here, we extend the framework of canonical correlation to include the estimation of multivariate nonlinear Granger causality for drawing inference about directed interaction. Its feasibility and effectiveness are verified on simulated data.

  12. Discrete canonical analysis of three dimensional gravity with cosmological constant

    CERN Document Server

    Berra-Montiel, J

    2014-01-01

    We discuss the interplay between standard canonical analysis and canonical discretization in three-dimensional gravity with cosmological constant. By using the Hamiltonian analysis, we find that the continuum local symmetries of the theory are given by the on-shell space-time diffeomorphisms, which at the action level, corresponds to the Kalb-Ramond transformations. At the time of discretization, although this symmetry is explicitly broken, we prove that the theory still preserves certain gauge freedom generated by a constant curvature relation in terms of holonomies and the Gauss's law in the lattice approach.

  13. Canonical extensions of the Johnson homomorphisms to the Torelli groupoid

    DEFF Research Database (Denmark)

    Bene, Alex; Kawazumi, Nariya; Penner, Robert

    2009-01-01

    We prove that every trivalent marked bordered fatgraph comes equipped with a canonical generalized Magnus expansion in the sense of Kawazumi. This Magnus expansion is used to give canonical extensions of the higher Johnson homomorphisms τm , for m 1 , to the Torelli groupoid, and we provide...... a recursive combinatorial formula for tensor representatives of these extensions. In particular, we give an explicit 1-cocycle in the dual fatgraph complex which extends τ2 and thus answer affirmatively a question of Morita and Penner. To illustrate our techniques for calculating higher Johnson homomorphisms...

  14. Catechistic Teaching, National Canons, and the Regimentation of Students' Voice

    Science.gov (United States)

    Kroon, Sjaak

    2013-01-01

    Drawing on key incident analysis of classroom transcripts from Bashkortostan, France, North Korea, and Suriname, this article discusses the relationship between an increasingly canonical content of education and the discursive organization of teaching processes at the expense of both teachers' and students' voice. It argues that canonical…

  15. Canonical enhancement as a result of Poisson distribution

    CERN Document Server

    Biro, T S

    2002-01-01

    We point out that a certain finite size effect in heavy ion physics, the canonical enhancement, is based on the difference of conservation constrained pair statistics for Poisson and Gauss distributions, respectively. Consequently it should occur in a wide range of phenomena, whenever comparing rare and frequent events.

  16. Universal critical wrapping probabilities in the canonical ensemble

    Directory of Open Access Journals (Sweden)

    Hao Hu

    2015-09-01

    Full Text Available Universal dimensionless quantities, such as Binder ratios and wrapping probabilities, play an important role in the study of critical phenomena. We study the finite-size scaling behavior of the wrapping probability for the Potts model in the random-cluster representation, under the constraint that the total number of occupied bonds is fixed, so that the canonical ensemble applies. We derive that, in the limit L→∞, the critical values of the wrapping probability are different from those of the unconstrained model, i.e. the model in the grand-canonical ensemble, but still universal, for systems with 2yt−d>0 where yt=1/ν is the thermal renormalization exponent and d is the spatial dimension. Similar modifications apply to other dimensionless quantities, such as Binder ratios. For systems with 2yt−d≤0, these quantities share same critical universal values in the two ensembles. It is also derived that new finite-size corrections are induced. These findings apply more generally to systems in the canonical ensemble, e.g. the dilute Potts model with a fixed total number of vacancies. Finally, we formulate an efficient cluster-type algorithm for the canonical ensemble, and confirm these predictions by extensive simulations.

  17. Connecting the Canon to Current Young Adult Literature

    Science.gov (United States)

    Rybakova, Katie; Roccanti, Rikki

    2016-01-01

    In this article we discuss the respective roles of young adult literature and literary texts in the secondary level English Language Arts classroom and explore the connections that can be made between popular young adult books and the traditional canon. We provide examples showing how young adult literature bestsellers such as "The Book…

  18. A canonical trace associated with certain spectral triples

    CERN Document Server

    Paycha, Sylvie

    2010-01-01

    In the abstract pseudodifferential set up of Connes and Moscovici, we prove a general formula for discrepancies of zeta-regularised traces associated with certain spectral triples and we introduce a canonical trace on operators whose order lies outside (minus) the dimension spectrum of the spectral triple.

  19. A Canonical Trace Associated with Certain Spectral Triples

    Directory of Open Access Journals (Sweden)

    Sylvie Paycha

    2010-09-01

    Full Text Available In the abstract pseudodifferential setup of Connes and Moscovici, we prove a general formula for the discrepancies of zeta-regularised traces associated with certain spectral triples, and we introduce a canonical trace on operators, whose order lies outside (minus the dimension spectrum of the spectral triple.

  20. A Canonical Trace Associated with Certain Spectral Triples

    Science.gov (United States)

    Paycha, Sylvie

    2010-09-01

    In the abstract pseudodifferential setup of Connes and Moscovici, we prove a general formula for the discrepancies of zeta-regularised traces associated with certain spectral triples, and we introduce a canonical trace on operators, whose order lies outside (minus) the dimension spectrum of the spectral triple.

  1. Non‐Canonical Replication Initiation: You’re Fired!

    Directory of Open Access Journals (Sweden)

    Bazilė Ravoitytė

    2017-01-01

    Full Text Available The division of prokaryotic and eukaryotic cells produces two cells that inherit a perfect copy of the genetic material originally derived from the mother cell. The initiation of canonical DNA replication must be coordinated to the cell cycle to ensure the accuracy of genome duplication. Controlled replication initiation depends on a complex interplay of cis‐acting DNA sequences, the so‐called origins of replication (ori, with trans‐acting factors involved in the onset of DNA synthesis. The interplay of cis‐acting elements and trans‐acting factors ensures that cells initiate replication at sequence‐specific sites only once, and in a timely order, to avoid chromosomal endoreplication. However, chromosome breakage and excessive RNA:DNA hybrid formation can cause breakinduced (BIR or transcription‐initiated replication (TIR, respectively. These non‐canonical replication events are expected to affect eukaryotic genome function and maintenance, and could be important for genome evolution and disease development. In this review, we describe the difference between canonical and non‐canonical DNA replication, and focus on mechanistic differences and common features between BIR and TIR. Finally, we discuss open issues on the factors and molecular mechanisms involved in TIR.

  2. Reputation, Canon-Formation, Pedagogy: George Orwell in the Classroom.

    Science.gov (United States)

    Rodden, John

    1991-01-01

    Investigates the process by which books become canonized in British and U.S. schools and universities. Uses the case of George Orwell to examine the institutional and historical factors which condition the inclusion and exclusion of writer's work in Anglo-American classrooms. (SR)

  3. Publication bias and the canonization of false facts

    DEFF Research Database (Denmark)

    Nissen, Silas Boye; Magidson, Tali; Gross, Kevin;

    2016-01-01

    canonized as fact. Data-dredging, p-hacking, and similar behaviors exacerbate the problem. Should negative results become easier to publish as a claim approaches acceptance as a fact, however, true and false claims would be more readily distinguished. To the degree that the model reflects the real world...

  4. Boundary-value problems for two-dimensional canonical systems

    NARCIS (Netherlands)

    Hassi, Seppo; De Snoo, H; Winkler, Henrik

    2000-01-01

    The two-dimensional canonical system Jy' = -lHy where the nonnegative Hamiltonian matrix function H(x) is trace-normed on (0,∞) has been studied in a function-theoretic way by L. de Branges. We show that the Hamiltonian system induces a closed symmetric relation which can be reduced to a, not necess

  5. Magnetic phase diagrams from non-collinear canonical band theory

    DEFF Research Database (Denmark)

    Shallcross, Sam; Nordstrom, L.; Sharma, S.

    2007-01-01

    to construct phase diagrams of magnetic order for the fcc and bcc lattices. Several examples of non-collinear magnetism are seen to be canonical in origin, in particular, that of gamma-Fe. In this approach, the determination of magnetic stability results solely from changes in kinetic energy due to spin...

  6. AN ALGORITHM FOR JORDAN CANONICAL FORM OF A QUATERNION MATRIX

    Institute of Scientific and Technical Information of China (English)

    姜同松; 魏木生

    2003-01-01

    In this paper, we first introduce a concept of companion vector, and studythe Jordan canonical forms of quaternion matrices by using the methods of complex representation and companion vector, not only give out a practical algorithm for Jordancanonical form J of a quaternion matrix A, but also provide a practical algorithm forcorresponding nonsingular matrix P with P- 1 AP = J.

  7. Testing the significance of canonical axes in redundancy analysis

    NARCIS (Netherlands)

    Legendre, P.; Oksanen, J.; Braak, ter C.J.F.

    2011-01-01

    1. Tests of significance of the individual canonical axes in redundancy analysis allow researchers to determine which of the axes represent variation that can be distinguished from random. Variation along the significant axes can be mapped, used to draw biplots or interpreted through subsequent anal

  8. Canonical realization of Bondi-Metzner-Sachs symmetry: Quadratic Casimir

    Science.gov (United States)

    Gomis, Joaquim; Longhi, Giorgio

    2016-01-01

    We study the canonical realization of Bondi-Metzner-Sacks symmetry for a massive scalar field introduced by Longhi and Materassi [J. Math. Phys. 40, 480 (1999)]. We construct an invariant scalar product for the generalized momenta. As a consequence we introduce a quadratic Casimir with the supertranslations.

  9. Canonical derivation of the Vlasov-Coulomb noncanonical Poisson structure

    Energy Technology Data Exchange (ETDEWEB)

    Kaufman, A.N.; Dewar, R.L.

    1983-09-01

    Starting from a Lagrangian formulation of the Vlasov-Coulomb system, canonical methods are used to define a Poisson structure for this system. Successive changes of representation then lead systematically to the noncanonical Lie-Poisson structure for functionals of the Vlasov distribution.

  10. Canonical averaging of the equations of quantum mechanics

    OpenAIRE

    Chirkov, A. G.

    2005-01-01

    The representation of a Schrodinger equations as a classic Hamiltonian system allows to construct a unified perturbation theory both in classic, and in a quantum mechanics grounded on the theory of canonical transformations, and also to receive asymptotic estimations of affinity of the precisian approximated solutions of Schrodinger equations

  11. CANONICAL COMPUTATIONAL FORMS FOR AR 2-D SYSTEMS

    NARCIS (Netherlands)

    ROCHA, P; WILLEMS, JC

    1990-01-01

    A canonical form for AR 2-D systems representations is introduced. This yields a method for computing the system trajectories by means of a line-by-line recursion, and displays some relevant information about the system structure such as the choice of inputs and initial conditions.

  12. The Hamiltonian Canonical Form for Euler-Lagrange Equations

    Institute of Scientific and Technical Information of China (English)

    ZHENG Yu

    2002-01-01

    Based on the theory of calculus of variation, some suffcient conditions are given for some Euler-Lagrangcequations to be equivalently represented by finite or even infinite many Hamiltonian canonical equations. Meanwhile,some further applications for equations such as the KdV equation, MKdV equation, the general linear Euler Lagrangeequation and the cylindric shell equations are given.

  13. IDENTIFICATION OF IDEOTYPES BY CANONICAL ANALYSIS IN Panicum maximum

    Directory of Open Access Journals (Sweden)

    Janaina Azevedo Martuscello

    2015-04-01

    Full Text Available Grouping of genotypes by canonical variable analysis is an important tool in breeding. It allows the grouping of individuals with similar characteristics that are associated with superior agronomic performance and may indicate the ideal profile of a plant for the region. The objective of the present study was to define, by canonical analysis, the agronomic profile of Panicum maximum plants adapted to the Agreste region. The experiment was conducted in a completely randomized design with 28 treatments, 22 genotypes of Panicum maximum, and cultivars Mombasa, Tanzania, Massai, Milenio, BRS Zuri, and BRS Tamani in triplicate in 4-m² plots. Plots were harvested five times and the following traits were evaluated: plant height; total, leaf, and stem; dead dry matter yields; leaf:stem ratio; leaf percentage; and volumetric density of forage. The analysis of canonical variables was performed based on the phenotypic means of the evaluated traits and on the residual variance and covariance matrix. Genotype PM34 showed higher mean leaf dry matter yield under the conditions of the Agreste of Alagoas (on average 53% higher than cultivars Mombasa, Tanzania, Milenio and Massai. It was possible to summarize the variation observed in eight agronomic characteristics in only two canonical variables accounting for 81.44 % of the data variation. The ideotype plant adapted to the conditions of the Agreste should be tall and present high leaf yield, leaf percentage, and leaf:stem ratio, and intermediate values ​​of volumetric density of forage.

  14. The Problematics of Postmodernism: The Double-Voiced Honors Canon.

    Science.gov (United States)

    McCracken, Tim

    Honors education is not immune from the current controversy concerning the role of the literary canon. Indeed, the problem seems especially crucial for honors programs, for their curriculums are often multi-disciplinary in their approaches to culture and history. The solution may lie in what Linda Hutcheon calls the "poetics of the…

  15. Imagined Victorians, Real Victorians, and the Literary Canon.

    Science.gov (United States)

    Fenstermaker, John J.

    1989-01-01

    Considers the issue of literary canons, raised in the context of a week-long series of lectures and discussions on "the Victorians" in an Elderhostel program, with participants for whom these texts were the product of their parents' generation and of their own childhood reading. Raises substantive questions about the meaning of a…

  16. Canonical Wnt signaling is necessary for object recognition memory consolidation.

    Science.gov (United States)

    Fortress, Ashley M; Schram, Sarah L; Tuscher, Jennifer J; Frick, Karyn M

    2013-07-31

    Wnt signaling has emerged as a potent regulator of hippocampal synaptic function, although no evidence yet supports a critical role for Wnt signaling in hippocampal memory. Here, we sought to determine whether canonical β-catenin-dependent Wnt signaling is necessary for hippocampal memory consolidation. Immediately after training in a hippocampal-dependent object recognition task, mice received a dorsal hippocampal (DH) infusion of vehicle or the canonical Wnt antagonist Dickkopf-1 (Dkk-1; 50, 100, or 200 ng/hemisphere). Twenty-four hours later, mice receiving vehicle remembered the familiar object explored during training. However, mice receiving Dkk-1 exhibited no memory for the training object, indicating that object recognition memory consolidation is dependent on canonical Wnt signaling. To determine how Dkk-1 affects canonical Wnt signaling, mice were infused with vehicle or 50 ng/hemisphere Dkk-1 and protein levels of Wnt-related proteins (Dkk-1, GSK3β, β-catenin, TCF1, LEF1, Cyclin D1, c-myc, Wnt7a, Wnt1, and PSD95) were measured in the dorsal hippocampus 5 min or 4 h later. Dkk-1 produced a rapid increase in Dkk-1 protein levels and a decrease in phosphorylated GSK3β levels, followed by a decrease in β-catenin, TCF1, LEF1, Cyclin D1, c-myc, Wnt7a, and PSD95 protein levels 4 h later. These data suggest that alterations in Wnt/GSK3β/β-catenin signaling may underlie the memory impairments induced by Dkk-1. In a subsequent experiment, object training alone rapidly increased DH GSK3β phosphorylation and levels of β-catenin and Cyclin D1. These data suggest that canonical Wnt signaling is regulated by object learning and is necessary for hippocampal memory consolidation.

  17. Point canonical transformation versus deformed shape invariance for position-dependent mass Schrodinger equation

    CERN Document Server

    Quesne, C

    2008-01-01

    On using the known equivalence between the presence of a position-dependent mass (PDM) in the Schr\\"odinger equation and a deformation of the canonical commutation relations, a method based on deformed shape invariance has recently been devised for generating pairs of potential and PDM for which the Schr\\"odinger equation is exactly solvable. This approach has provided the bound-state energy spectrum, as well as the ground-state and the first few excited-state wavefunctions. The general wavefunctions have however remained unknown in explicit form because for their determination one would need the solutions of a rather tricky differential-difference equation. Here we show that solving this equation may be avoided by combining the deformed shape invariance technique with the point canonical transformation method in a novel way. It consists in employing our previous knowledge of the PDM problem energy spectrum to construct a constant-mass Schr\\"odinger equation with similar characteristics and in deducing the PD...

  18. Canonical sound speed profile and related ray acoustic parameters in the Bay of Bengal

    Digital Repository Service at National Institute of Oceanography (India)

    Murty, T.V.R.; Sadhuram, Y.; Rao, M.M.M.; Rao, B.P.; SuryaPrakash, S.; Chandramouli, P.; Murthy, K.S.R.; Prasad, K.V.S.R.

    Following Munk's canonical theory, canonical parameters (i.e., B the stratification scale and epsilon the perturbation coefficient) in adiabatic ocean are obtained using SOFAR channel parameters (i.e., C sound velocity at the channel axis, Z sub(1...

  19. Climate Prediction Center(CPC)Ensemble Canonical Correlation Analysis Forecast of Temperature

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Ensemble Canonical Correlation Analysis (ECCA) temperature forecast is a 90-day (seasonal) outlook of US surface temperature anomalies. The ECCA uses Canonical...

  20. Cosmopolitan sociology and the classical canon: Ferdinand Tönnies and the emergence of global Gesellschaft.

    Science.gov (United States)

    Inglis, David

    2009-12-01

    How relevant are figures from the classical sociological canon for present day efforts to found cosmopolitan forms of sociological thought? According to the critique of Ulrich Beck, the classical sociologists remain far too wedded to nation-state-centred ways of thinking to play an important role in the development of cosmopolitan sociology. This paper argues that such a critique fails to account for the ways in which certain classical sociologists were attuned to the emerging cosmopolitical conditions of their own time, were not wholly wedded to nation-state-based conceptualizations, and thus can function as both groundings of, and inspirations for, cosmopolitan sociological endeavours. The apparently unpromising case of Tönnies is focused on, the paper showing how he outlined an account of how and why a planet-spanning condition of Gesellschaft developed a position which diverges from and counterpoints Marx's analysis of similar phenomena in important ways. The stereotype of Tönnies as an arch-conservative is also dissolved, allowing him to be considered as one of the most important antecedents of contemporary cosmopolitan sociological practice and a canonical figure still relevant for present-day purposes.

  1. Web bases for sl(3) are not dual canonical

    CERN Document Server

    Khovanov, M; Khovanov, Michael; Kuperberg, Greg

    1997-01-01

    We compare two natural bases for the invariant space of a tensor product of irreducible representations of A2, or sl(3). One basis is the web basis, defined from a skein theory called the combinatorial A2 spider. The other basis is the dual canonical basis, the dual of the basis defined by Lusztig and Kashiwara. For sl(2) or A1, the web bases have been discovered many times and were recently shown to be dual canonical by Frenkel and Khovanov. We prove that for sl(3), the two bases eventually diverge even though they agree in many small cases. The first disagreement comes in the invariant space Inv((V^+ tensor V^+ tensor V^- tensor V^-)^{tensor 3)), where V^+ and V^- are the two 3-dimensional representations of sl(3); if the tensor factors are listed in the indicated order, only 511 of the 512 invariant basis vectors coincide.

  2. Some reference formulas for the generating functions of canonical transformations

    CERN Document Server

    Anselmi, Damiano

    2015-01-01

    We study some properties of the canonical transformations in classical mechanics and quantum field theory and give a number of practical formulas concerning their generating functions. First, we give a diagrammatic formula for the perturbative expansion of the composition law around the identity map. Then, we propose a standard way to express the generating function of a canonical transformation by means of a certain "componential" map, which obeys the Baker-Campbell-Hausdorff formula. We derive the diagrammatic interpretation of the componential map, work out its relation with the solution of the Hamilton-Jacobi equation and derive its time-ordered version. Finally, we generalize the results to the Batalin-Vilkovisky formalism, where the conjugate variables may have both bosonic and fermionic statistics, and describe applications to quantum field theory.

  3. A Top-Down Account of Linear Canonical Transforms

    Directory of Open Access Journals (Sweden)

    Kurt Bernardo Wolf

    2012-06-01

    Full Text Available We contend that what are called Linear Canonical Transforms (LCTs should be seen as a part of the theory of unitary irreducible representations of the '2+1' Lorentz group. The integral kernel representation found by Collins, Moshinsky and Quesne, and the radial and hyperbolic LCTs introduced thereafter, belong to the discrete and continuous representation series of the Lorentz group in its parabolic subgroup reduction. The reduction by the elliptic and hyperbolic subgroups can also be considered to yield LCTs that act on functions, discrete or continuous in other Hilbert spaces. We gather the summation and integration kernels reported by Basu and Wolf when studiying all discrete, continuous, and mixed representations of the linear group of 2×2 real matrices. We add some comments on why all should be considered canonical.

  4. Publication bias and the canonization of false facts

    CERN Document Server

    Nissen, Silas B; Gross, Kevin; Bergstrom, Carl T

    2016-01-01

    In the process of scientific inquiry, certain claims accumulate enough support to be established as facts. Unfortunately, not every claim accorded the status of fact turns out to be true. In this paper, we model the dynamic process by which claims are canonized as fact through repeated experimental confirmation. The community's confidence in a claim constitutes a Markov process: each successive published result shifts the degree of belief, until sufficient evidence accumulates to accept the claim as fact or to reject it as false. In our model, publication bias --- in which positive results are published preferentially over negative ones --- influences the distribution of published results. We find that when readers do not know the degree of publication bias and thus cannot condition on it, false claims often can be canonized as facts. Unless a sufficient fraction of negative results are published, the scientific process will do a poor job at discriminating false from true claims. This problem is exacerbated w...

  5. A canonical correlation neural network for multicollinearity and functional data.

    Science.gov (United States)

    Gou, Zhenkun; Fyfe, Colin

    2004-03-01

    We review a recent neural implementation of Canonical Correlation Analysis and show, using ideas suggested by Ridge Regression, how to make the algorithm robust. The network is shown to operate on data sets which exhibit multicollinearity. We develop a second model which not only performs as well on multicollinear data but also on general data sets. This model allows us to vary a single parameter so that the network is capable of performing Partial Least Squares regression (at one extreme) to Canonical Correlation Analysis (at the other)and every intermediate operation between the two. On multicollinear data, the parameter setting is shown to be important but on more general data no particular parameter setting is required. Finally, we develop a second penalty term which acts on such data as a smoother in that the resulting weight vectors are much smoother and more interpretable than the weights without the robustification term. We illustrate our algorithms on both artificial and real data.

  6. Some reference formulas for the generating functions of canonical transformations

    Energy Technology Data Exchange (ETDEWEB)

    Anselmi, Damiano [Universita di Pisa, Dipartimento di Fisica ' ' Enrico Fermi' ' , Pisa (Italy); INFN, Sezione di Pisa, Pisa (Italy)

    2016-02-15

    We study some properties of the canonical transformations in classical mechanics and quantum field theory and give a number of practical formulas concerning their generating functions. First, we give a diagrammatic formula for the perturbative expansion of the composition law around the identity map. Then we propose a standard way to express the generating function of a canonical transformation by means of a certain ''componential'' map, which obeys the Baker-Campbell-Hausdorff formula. We derive the diagrammatic interpretation of the componential map, work out its relation with the solution of the Hamilton-Jacobi equation and derive its time-ordered version. Finally, we generalize the results to the Batalin-Vilkovisky formalism, where the conjugate variables may have both bosonic and fermionic statistics, and describe applications to quantum field theory. (orig.)

  7. Canonical reduction for dilatonic gravity in 3+1 dimensions

    CERN Document Server

    Scott, T C; Mann, R B; Fee, G J

    2016-01-01

    We generalize the 1+1-dimensional gravity formalism of Ohta and Mann to 3+1 dimensions by developing the canonical reduction of a proposed formalism applied to a system coupled with a set of point particles. This is done via the Arnowitt-Deser-Misner method and by eliminating the resulting constraints and imposing coordinate conditions. The reduced Hamiltonian is completely determined in terms of the particles' canonical variables (coordinates, dilaton field and momenta). It is found that the equation governing the dilaton field under suitable gauge and coordinate conditions, including the absence of transverse-traceless metric components, is a logarithmic Schroedinger equation. Thus, although different, the 3+1 formalism retains some essential features of the earlier 1+1 formalism, in particular the means of obtaining a quantum theory for dilatonic gravity.

  8. Canonically Transformed Detectors Applied to the Classical Inverse Scattering Problem

    CERN Document Server

    Jung, C; Torres, J M

    2005-01-01

    The concept of measurement in classical scattering is interpreted as an overlap of a particle packet with some area in phase space that describes the detector. Considering that usually we record the passage of particles at some point in space, a common detector is described e.g. for one-dimensional systems as a narrow strip in phase space. We generalize this concept allowing this strip to be transformed by some, possibly non-linear, canonical transformation, introducing thus a canonically transformed detector. We show such detectors to be useful in the context of the inverse scattering problem in situations where recently discovered scattering echoes could not be seen without their help. More relevant applications in quantum systems are suggested.

  9. Canonically Transformed Detectors Applied to the Classical Inverse Scattering Problem

    Science.gov (United States)

    Jung, C.; Seligman, T. H.; Torres, J. M.

    The concept of measurement in classical scattering is interpreted as an overlap of a particle packet with some area in phase space that describes the detector. Considering that usually we record the passage of particles at some point in space, a common detector is described e.g. for one-dimensional systems as a narrow strip in phase space. We generalize this concept allowing this strip to be transformed by some, possibly non-linear, canonical transformation, introducing thus a canonically transformed detector. We show such detectors to be useful in the context of the inverse scattering problem in situations where recently discovered scattering echoes could not be seen without their help. More relevant applications in quantum systems are suggested.

  10. Lorentz Covariant Canonical Symplectic Algorithms for Dynamics of Charged Particles

    CERN Document Server

    Wang, Yulei; Qin, Hong

    2016-01-01

    In this paper, the Lorentz covariance of algorithms is introduced. Under Lorentz transformation, both the form and performance of a Lorentz covariant algorithm are invariant. To acquire the advantages of symplectic algorithms and Lorentz covariance, a general procedure for constructing Lorentz covariant canonical symplectic algorithms (LCCSA) is provided, based on which an explicit LCCSA for dynamics of relativistic charged particles is built. LCCSA possesses Lorentz invariance as well as long-term numerical accuracy and stability, due to the preservation of discrete symplectic structure and Lorentz symmetry of the system. For situations with time-dependent electromagnetic fields, which is difficult to handle in traditional construction procedures of symplectic algorithms, LCCSA provides a perfect explicit canonical symplectic solution by implementing the discretization in 4-spacetime. We also show that LCCSA has built-in energy-based adaptive time steps, which can optimize the computation performance when th...

  11. Canonical Strangeness and Distillation Effects in Hadron Production

    CERN Document Server

    Toneev, V D

    2004-01-01

    Strangeness canonical ensemble for Maxwell-Boltzmann statistics is reconsidered for excited nuclear systems with non-vanishing net strangeness. A new recurrence relation method is applied to find the partition function. The method is first generalized to the case of quantum strangeness canonical ensemble. Uncertainties in calculation of the K+/pi+ excitation function are discussed. A new scenario based on the strangeness distillation effect is put forward for a possible explanation of anomalous strangeness production observed at the bombarding energy near 30 AGeV. The peaked maximum in the K+/pi+ ratio is considered as a sign of the critical end-point reached in evolution of the system rather than a latent heat jump emerging from the onset of the first order deconfinement phase transition.

  12. Some reference formulas for the generating functions of canonical transformations

    Science.gov (United States)

    Anselmi, Damiano

    2016-02-01

    We study some properties of the canonical transformations in classical mechanics and quantum field theory and give a number of practical formulas concerning their generating functions. First, we give a diagrammatic formula for the perturbative expansion of the composition law around the identity map. Then we propose a standard way to express the generating function of a canonical transformation by means of a certain "componential" map, which obeys the Baker-Campbell-Hausdorff formula. We derive the diagrammatic interpretation of the componential map, work out its relation with the solution of the Hamilton-Jacobi equation and derive its time-ordered version. Finally, we generalize the results to the Batalin-Vilkovisky formalism, where the conjugate variables may have both bosonic and fermionic statistics, and describe applications to quantum field theory.

  13. New QCD sum rules based on canonical commutation relations

    Science.gov (United States)

    Hayata, Tomoya

    2012-04-01

    New derivation of QCD sum rules by canonical commutators is developed. It is the simple and straightforward generalization of Thomas-Reiche-Kuhn sum rule on the basis of Kugo-Ojima operator formalism of a non-abelian gauge theory and a suitable subtraction of UV divergences. By applying the method to the vector and axial vector current in QCD, the exact Weinberg’s sum rules are examined. Vector current sum rules and new fractional power sum rules are also discussed.

  14. Conformal invariance and Hojman conserved quantities of canonical Hamilton systems

    Institute of Scientific and Technical Information of China (English)

    Liu Chang; Liu Shi-Xing; Mei Feng-Xiang; Guo Yong-Xin

    2009-01-01

    This paper discusses the conformal invariance by infinitesimal transformations of canonical Hamilton systems. The necessary and sufficient conditions of conformal invariance being Lie symmetrical simultaneously by the action of infinitesimal transformations are given. The determining equations of the conformal invariance are gained. Then the Hojman conserved quantities of conformal invariance by special infinitesimal transformations are obtained. Finally an illustrative example is given to verify the results.

  15. On Black Hole Entropy Corrections in the Grand Canonical Ensemble

    CERN Document Server

    Mahapatra, Subhash; Sarkar, Tapobrata

    2011-01-01

    We study entropy corrections due to thermal fluctuations for asymptotically AdS black holes in the grand canonical ensemble. To leading order, these can be expressed in terms of the black hole response coefficients via fluctuation moments. We also analyze entropy corrections due to mass and charge fluctuations of R-charged black holes, and our results indicate an universality in the logarithmic corrections to charged AdS black hole entropy in various dimensions.

  16. Generic uniqueness conditions for the canonical polyadic decomposition and INDSCAL

    OpenAIRE

    Domanov, Ignat; De Lathauwer, Lieven

    2014-01-01

    We find conditions that guarantee that a decomposition of a generic third-order tensor in a minimal number of rank-$1$ tensors (canonical polyadic decomposition (CPD)) is unique up to permutation of rank-$1$ tensors. Then we consider the case when the tensor and all its rank-$1$ terms have symmetric frontal slices (INDSCAL). Our results complement the existing bounds for generic uniqueness of the CPD and relax the existing bounds for INDSCAL. The derivation makes use of algebraic geometry. We...

  17. The canonical Kravchuk basis for discrete quantum mechanics

    Science.gov (United States)

    Hakioglu, Tugrul; Wolf, Kurt Bernardo

    2000-04-01

    The well known Kravchuk formalism of the harmonic oscillator obtained from the direct discretization method is shown to be a new way of formulating discrete quantum phase space. It is shown that the Kravchuk oscillator Hamiltonian has a well defined unitary canonical partner which we identify with the quantum phase of the Kravchuk oscillator. The generalized discrete Wigner function formalism based on the action and angle variables is applied to the Kravchuk oscillator and its continuous limit is examined.

  18. Improved Dictionary Formation and Search for Synthetic Aperture Radar Canonical Shape Feature Extraction

    Science.gov (United States)

    2014-03-27

    IMPROVED DICTIONARY FORMATION AND SEARCH FOR SYNTHETIC APERTURE RADAR CANONICAL SHAPE FEATURE EXTRACTION THESIS Matthew P. Crosser, Captain, USAF... SYNTHETIC APERTURE RADAR CANONICAL SHAPE FEATURE EXTRACTION THESIS Presented to the Faculty Department of Electrical and Computer Engineering Graduate School...APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED AFIT-ENG-14-M-21 IMPROVED DICTIONARY FORMATION AND SEARCH FOR SYNTHETIC APERTURE RADAR CANONICAL

  19. Variational principle and phase space measure in non-canonical coordinates

    Directory of Open Access Journals (Sweden)

    Sergi, A

    2005-11-01

    Full Text Available Non-canonical equations of motion are derived from a variational principle written in symplectic form. The invariant measure of phase space and the covariant expression for the entropy are derived from non-canonical transformations of coordinates. This shows that the geometry of non-canonical phase space is non trivial even if dynamics has no compressibility.

  20. Study of parametrized dark energy models with a general non-canonical scalar field

    Energy Technology Data Exchange (ETDEWEB)

    Al Mamon, Abdulla; Das, Sudipta [Visva-Bharati, Department of Physics, Santiniketan (India)

    2016-03-15

    In this paper, we consider various dark energy models in the framework of a non-canonical scalar field with a Lagrangian density of the form L(φ, X) = f(φ)X ((X)/(M{sup 4}{sub Pl})){sup α-1} - V(φ), which provides the standard canonical scalar field model for α = 1 and f(φ) = 1. In this particular non-canonical scalar field model, we carry out the analysis for α = 2. We then obtain cosmological solutions for constant as well as variable equation of state parameter (ω{sub φ}(z)) for dark energy. We also perform the data analysis for three different functional forms of ω{sub φ}(z) by using the combination of SN Ia, BAO, and CMB datasets.We have found that for all the choices of ω{sub φ}(z), the SN Ia + CMB/BAO dataset favors the past decelerated and recent accelerated expansion phase of the universe. Furthermore, using the combined dataset, we have observed that the reconstructed results of ω{sub φ}(z) and q(z) are almost choice independent and the resulting cosmological scenarios are in good agreement with the ΛCDM model (within the 1σ confidence contour). We have also derived the form of the potentials for each model and the resulting potentials are found to be a quartic potential for constant ω{sub φ} and a polynomial in φ for variable ω{sub φ}. (orig.)

  1. A canonical theory of dynamic decision-making

    Directory of Open Access Journals (Sweden)

    John eFox

    2013-04-01

    Full Text Available Decision-making behaviour is studied in many very different fields, from medicine and economics to psychology and neuroscience, with major contributions from mathematics and statistics, computer science, AI and other technical disciplines. However the conceptualisation of what decision-making is and methods for studying it vary greatly and this has resulted in fragmentation of the field. A theory that can accommodate various perspectives may facilitate interdisciplinary working. We present such a theory in which decision-making is articulated as a set of canonical functions that are sufficiently general to accommodate diverse viewpoints, yet sufficiently precise that they can be instantiated in different ways for specific theoretical or practical purposes. The canons cover the whole decision cycle, from the framing of a decision based on the goals, beliefs, and background knowledge of the decision maker to the formulation of decision options, establishing preferences over them, and making commitments. Commitments can lead to the initiation of new decisions and any step in the cycle can incorporate reasoning about previous decisions and the rationales for them, and lead to revising or abandoning existing commitments. The theory situates decision making with respect to other high-level cognitive capabilities like problem-solving, planning and collaborative decision-making. The canonical approach is assessed in three domains: cognitive and neuro-psychology, artificial intelligence, and decision engineering.

  2. A canonical theory of dynamic decision-making.

    Science.gov (United States)

    Fox, John; Cooper, Richard P; Glasspool, David W

    2013-01-01

    Decision-making behavior is studied in many very different fields, from medicine and economics to psychology and neuroscience, with major contributions from mathematics and statistics, computer science, AI, and other technical disciplines. However the conceptualization of what decision-making is and methods for studying it vary greatly and this has resulted in fragmentation of the field. A theory that can accommodate various perspectives may facilitate interdisciplinary working. We present such a theory in which decision-making is articulated as a set of canonical functions that are sufficiently general to accommodate diverse viewpoints, yet sufficiently precise that they can be instantiated in different ways for specific theoretical or practical purposes. The canons cover the whole decision cycle, from the framing of a decision based on the goals, beliefs, and background knowledge of the decision-maker to the formulation of decision options, establishing preferences over them, and making commitments. Commitments can lead to the initiation of new decisions and any step in the cycle can incorporate reasoning about previous decisions and the rationales for them, and lead to revising or abandoning existing commitments. The theory situates decision-making with respect to other high-level cognitive capabilities like problem solving, planning, and collaborative decision-making. The canonical approach is assessed in three domains: cognitive and neuropsychology, artificial intelligence, and decision engineering.

  3. Alla ricerca di un canone europeo tra plurilinguismo e multiculturalità

    Directory of Open Access Journals (Sweden)

    Michaela Böhmig

    2004-12-01

    Full Text Available In Search of a European Canon between Multilingualism and Multiculturalism The article's aim is to point out a series of problems related to 1 the “new” Europe, 2 the “European” canon, and 3 multilingualism and multiculturalism. The author moves from the evidence that the political priority of redesigning the enlarged European Union’s new borders involves the risk to let aside the equally or even more important task to redefine the “European” roots and to establish shared cultural values, and she raises the question of what is to be considered “Europe” and “European”. Reviewing the fundamental works, which in an centripetal effort try to collect the basic myths and themes of the Western and/or European cultural space, such as Stoffe der Weltliteratur by Elisabeth Frenzel (Stuttgart 19887, Dictionnaire des Mythes Littéraires, edited by Pierre Brunel (Paris 1988, The Western Canon by Harold Bloom (New York 1994, and Europa: tema y variaciones (Madrid 2000 by José Antonio Jáuregui, the author remarks that the contribution of the Eastern European countries to what should be a common inheritance seems to be very small or even non-existent. Since this disproportion cannot be ascribed to an inadequate cultural production, the only explanation remains a prevailing one-way influence from West to East . and not vice versa . and a consequent one-sided perception by European scholars. In order to establish a complete “European” canon, it is therefore necessary to enlarge the borders toward East and to include the Slavic area. An opposite approach can be observed in language policy, which in a centrifugal effort, due to the objective difficulty to choose or produce a common European language, insists on an equal status for all European languages, from the major national languages to those of ethnic minorities, all to be preserved by means of “positive discrimination”. Besides the difficulty to govern a federation of countries

  4. Application of canonical coordinates for solving single-freedom constraint mechanical systems

    Institute of Scientific and Technical Information of China (English)

    高芳; 张晓波; 傅景礼

    2014-01-01

    This paper introduces the canonical coordinates method to obtain the first integral of a single-degree freedom constraint mechanical system that contains conserva-tive and non-conservative constraint homonomic systems. The definition and properties of canonical coordinates are introduced. The relation between Lie point symmetries and the canonical coordinates of the constraint mechanical system are expressed. By this re-lation, the canonical coordinates can be obtained. Properties of the canonical coordinates and the Lie symmetry theory are used to seek the first integrals of constraint mechanical system. Three examples are used to show applications of the results.

  5. Canonical Acoustics and Its Application to Surface Acoustic Wave on Acoustic Metamaterials

    Science.gov (United States)

    Shen, Jian Qi

    2016-08-01

    In a conventional formalism of acoustics, acoustic pressure p and velocity field u are used for characterizing acoustic waves propagating inside elastic/acoustic materials. We shall treat some fundamental problems relevant to acoustic wave propagation alternatively by using canonical acoustics (a more concise and compact formalism of acoustic dynamics), in which an acoustic scalar potential and an acoustic vector potential (Φ ,V), instead of the conventional acoustic field quantities such as acoustic pressure and velocity field (p,u) for characterizing acoustic waves, have been defined as the fundamental variables. The canonical formalism of the acoustic energy-momentum tensor is derived in terms of the acoustic potentials. Both the acoustic Hamiltonian density and the acoustic Lagrangian density have been defined, and based on this formulation, the acoustic wave quantization in a fluid is also developed. Such a formalism of acoustic potentials is employed to the problem of negative-mass-density assisted surface acoustic wave that is a highly localized surface bound state (an eigenstate of the acoustic wave equations). Since such a surface acoustic wave can be strongly confined to an interface between an acoustic metamaterial (e.g., fluid-solid composite structures with a negative dynamical mass density) and an ordinary material (with a positive mass density), it will give rise to an effect of acoustic field enhancement on the acoustic interface, and would have potential applications in acoustic device design for acoustic wave control.

  6. The Resurrection of Jesus: do extra-canonical sources change the landscape?

    Directory of Open Access Journals (Sweden)

    F P Viljoen

    2005-10-01

    Full Text Available The resurrection of Jesus is assumed by the New Testament to be a historical event. Some scholars argue, however, that there was no empty tomb, but that the New Testament accounts are midrashic or mythological stories about Jesus.� In this article extra-canonical writings are investigated to find out what light it may throw on intra-canonical tradition. Many extra-canonical texts seemingly have no knowledge of the passion and resurrection, and such traditions may be earlier than the intra-canonical traditions. Was the resurrection a later invention?� Are intra-canonical texts developments of extra-canonical tradition, or vice versa?� This article demonstrates that extra-canonical texts do not materially alter the landscape of enquiry.

  7. Canonical charges and asymptotic symmetry algebra of conformal gravity

    CERN Document Server

    Irakleidou, Maria; Preis, Florian

    2014-01-01

    We study canonical conformal gravity in four dimensions and construct the gauge generators and the associated charges. Using slightly generalized boundary conditions compared to those in \\cite{Grumiller:2013mxa} we find that the charges associated with space-time diffeomorphisms are finite and conserved in time. They are also shown to agree with the Noether charges found in \\cite{Grumiller:2013mxa}. However, there exists no charge associated with Weyl transformations. Consequently the asymptotic symmetry algebra is isomorphic to the Lie algebra of the boundary condition preserving diffeomorphisms. For illustrative purposes we apply the results to the Mannheim--Kazanas--Riegert solution of conformal gravity.

  8. Origins and canons: medicine and the history of sociology.

    Science.gov (United States)

    Collyer, Fran

    2010-01-01

    Differing accounts are conventionally given of the origins of medical sociology and its parent discipline sociology. These distinct "histories" are justified on the basis that the sociological founders were uninterested in medicine, mortality and disease. This article challenges these "constructions" of the past, proposing the theorization of health not as a "late development of sociology" but an integral part of its formation. Drawing on a selection of key sociological texts, it is argued that evidence of the founders' sustained interest in the infirmities of the individual, of mortality, and in medicine, have been expunged from the historical record through processes of "canonization" and "medicalization."

  9. Alatriste y Quevedo: nación y canon literario

    OpenAIRE

    Otero Blanco, Ángel

    2011-01-01

    Arturo Pérez-Reverte concibe la lengua y la literatura españolas como emblemas nacionales, como monumentos indiscutibles del patrimonio cultural de España. En Pérez- Reverte, el canon de la literatura española es, como sostiene Pierre Nora (2001: xix) a propósito de la cultura material de Francia, uno de los «lugares de memoria» del imaginario histórico español, un inmenso monumento nacional de obligada visita (lectura). Pérez-Reverte, igual que Itamar Even-Zohar (1994: 357-8),...

  10. Nucleon form factors in the canonically quantized Skyrme model

    Energy Technology Data Exchange (ETDEWEB)

    Acus, A.; Norvaisas, E. [Lithuanian Academy of Sciences, Vilnius (Lithuania). Inst. of Theoretical Physics and Astronomy; Riska, D.O. [Helsinki Univ. (Finland). Dept. of Physics; Helsinki Univ. (Finland). Helsinki Inst. of Physics

    2001-08-01

    The explicit expressions for the electric, magnetic, axial and induced pseudoscalar form factors of the nucleons are derived in the ab initio quantized Skyrme model. The canonical quantization procedure ensures the existence of stable soliton solutions with good quantum numbers. The form factors are derived for representations of arbitrary dimension of the SU(2) group. After fixing the two parameters of the model, f{sub {pi}} and e, by the empirical mass and electric mean square radius of the proton, the calculated electric and magnetic form factors are fairly close to the empirical ones, whereas the the axial and induced pseudoscalar form factors fall off too slowly with momentum transfer. (orig.)

  11. The $\\alpha$ particle as a canonically quantized multiskyrmion

    CERN Document Server

    Acus, A; Riska, D O

    2006-01-01

    The rational map approximation to the solution to the SU(2) Skyrme model with baryon number B=4 is canonically quantized. The quantization procedure leads to anomalous breaking of the chiral symmetry, and exponential falloff of the energy density of the soliton at large distances. The model is extended to SU(2) representations of arbitrary dimension. These soliton solutions capture the double node feature of the empirical $\\alpha$ particle charge form factor, but as expected lead to a too compact matter distribution. Comparison to phenomenology indicates a preference for the fundamental representation.

  12. Nucleon form factors in the canonically quantized Skyrme model

    CERN Document Server

    Acus, A; Riska, D O

    2001-01-01

    The explicit expressions for the electric, magnetic, axial and induced pseudoscalar form factors of the nucleons are derived in the {\\it ab initio} quantized Skyrme model. The canonical quantization procedure ensures the existence of stable soliton solutions with good quantum numbers. The form factors are derived for representations of arbitrary dimension of the SU(2) group. After fixing the two parameters of the model, $f_\\pi$ and $e$, by the empirical mass and electric mean square radius of the proton, the calculated electric and magnetic form factors are fairly close to the empirical ones, whereas the the axial and induced pseudoscalar form factors fall off too slowly with momentum transfer.

  13. Estimation of the Heteroskedastic Canonical Contagion Model with Instrumental Variables

    Science.gov (United States)

    2016-01-01

    Knowledge of contagion among economies is a relevant issue in economics. The canonical model of contagion is an alternative in this case. Given the existence of endogenous variables in the model, instrumental variables can be used to decrease the bias of the OLS estimator. In the presence of heteroskedastic disturbances this paper proposes the use of conditional volatilities as instruments. Simulation is used to show that the homoscedastic and heteroskedastic estimators which use them as instruments have small bias. These estimators are preferable in comparison with the OLS estimator and their asymptotic distribution can be used to construct confidence intervals. PMID:28030628

  14. The Algebraic Riccati Matrix Equation for Eigendecomposition of Canonical Forms

    Directory of Open Access Journals (Sweden)

    M. Nouri

    2013-01-01

    Full Text Available The algebraic Riccati matrix equation is used for eigendecomposition of special structured matrices. This is achieved by similarity transformation and then using the algebraic Riccati matrix equation to the triangulation of matrices. The process is the decomposition of matrices into small and specially structured submatrices with low dimensions for easy finding of eigenpairs. Here, we show that previous canonical forms I, II, III, and so on are special cases of the presented method. Numerical and structural examples are included to show the efficiency of the present method.

  15. El canon literario mexicano en Los detectives salvajes

    Directory of Open Access Journals (Sweden)

    Carmen de Mora

    2015-02-01

    Full Text Available En el presente artículo se examina el canon personal de Bolaño en Los detectives salvajes acerca de la literatura mexicana, a partir de la intertextualidad entendida como un rasgo característico de la narrativa postmoderna del autor. Para ello se han tenido en cuenta tanto las citas explícitas que aparecen en la novela como algunas citas implícitas fundamentales. A través del análisis de las mismas se pretende demostrar que para entender el alcance de esta obra es preciso enfrentarse a su escritura en palimpsesto.

  16. Mapping of shape invariant potentials by the point canonical transformation

    CERN Document Server

    Setare, M R

    2008-01-01

    In this paper by using the method of point canonical transformation we find that the Coulomb and Kratzer potentials can be mapped to the Morse potential. Then we show that the P\\"{o}schl-Teller potential type I belongs to the same subclass of shape invariant potentials as Hulth\\'{e}n potential. Also we show that the shape-invariant algebra for Coulomb, Kratzer, and Morse potentials is SU(1,1), while the shape-invariant algebra for P\\"{o}schl-Teller type I and Hulth\\'{e}n is SU(2).

  17. Why Canonical Disks Cannot Produce Advection Dominated Flows

    CERN Document Server

    Molteni, D; Valenza, M A

    2001-01-01

    Using simple arguments we show that the canonical thin keplerian accretion disks cannot smoothly match any plain advection dominated flow (ADAF) model. By 'plain' ADAF model we mean the ones with zero cooling. The existence of sonic points in exact solutions is critical and imposes constraints that cannot be surpassed adopting 'reasonable' physical conditions at the hypothetical match point. Only the occurrence of new critical physical phenomena may produce a transition. We propose that exact advection models are a class of solutions which don't necessarily involve the standard thin cool disks and suggest a different scenario in which good ADAF solutions could eventually occur.

  18. 3d mirror symmetry as a canonical transformation

    CERN Document Server

    Drukker, Nadav

    2015-01-01

    We generalize the free Fermi-gas formulation of certain 3d ${\\cal N}=3$ supersymmetric Chern-Simons-matter theories by allowing Fayet-Iliopoulos couplings as well as mass terms for bifundamental matter fields. The resulting partition functions are given by simple modifications of the argument of the Airy function found previously. With these extra parameters it is easy to see that mirror-symmetry corresponds to linear canonical transformations on the phase space (or operator algebra) of the 1-dimensional fermions.

  19. Canonical ensemble approach to graded-response perceptrons

    Science.gov (United States)

    Bollé, D.; Erichsen, R., Jr.

    1999-03-01

    Perceptrons with graded input-output relations and a limited output precision are studied within the Gardner-Derrida canonical ensemble approach. Soft non-negative error measures are introduced allowing for extended retrieval properties. In particular, the performance of these systems for a linear (quadratic) error measure, corresponding to the perceptron (adaline) learning algorithm, is compared with the performance for a rigid error measure, simply counting the number of errors. Replica-symmetry-breaking effects are evaluated, and the analytic results are compared with numerical simulations.

  20. The canonical ring of a 3-connected curve

    CERN Document Server

    Franciosi, Marco

    2011-01-01

    Let C be a Gorenstein curve which is either reduced or contained in a smooth algebraic surface. We show that the canonical ring R(C, \\omega_C)=\\oplus_{k \\geq 0} H^0(C, \\omega_C^k) is generated in degree 1 if C is 3-connected and not (honestly) hyperelliptic; we show moreover that R(C, L)=\\oplus_{k \\geq 0} H^0(C,L^k) is generated in degree 1 if C is reduced and L is an invertible sheaf such that deg L_{|B} \\geq 2p_a(B)+1 for every subcurve B \\subset C.

  1. Canonical energy and hairy AdS black holes

    CERN Document Server

    Hyun, Seungjoon; Yi, Sang-Heon

    2016-01-01

    We propose the modified version of the canonical energy which was introduced originally by Hollands and Wald. Our construction depends only on the Euler-Lagrange expression of the system and thus is independent of the ambiguity in the Lagrangian. After some comments on our construction, we briefly mention on the relevance of our construction to the boundary information metric in the context of the AdS/CFT correspondence. We also study the stability of three-dimensional hairy extremal black holes by using our construction.

  2. Parametric Potential Determination by the Canonical Function Method

    CERN Document Server

    Tannous, C; Langlois, J M

    1999-01-01

    The canonical function method (CFM) is a powerful means for solving the Radial Schrodinger Equation. The mathematical difficulty of the RSE lies in the fact it is a singular boundary value problem. The CFM turns it into a regular initial value problem and allows the full determination of the spectrum of the Schrodinger operator without calculating the eigenfunctions. Following the parametrisation suggested by Klapisch and Green, Sellin and Zachor we develop a CFM to optimise the potential parameters in order to reproduce the experimental Quantum Defect results for various Rydberg series of He, Ne and Ar as evaluated from Moore's data.

  3. Canon musical y canon musicológico desde una perspectiva de la música chilena

    Directory of Open Access Journals (Sweden)

    Luis Merino Montero

    2006-06-01

    Full Text Available El canon y el acto de canonizar forman parte de un juicio de valor aplicable a la música de arte europea, en una tripartición que involucra al creador, su obra y el impacto de la música en un receptor o público como resultado del proceso social de comunicación. Durante muchos años la música centroeuropea y su canon representó en Latinoamérica el lenguaje musical por excelencia, al cual se subordinaban todos los otros lenguajes musicales cultivados en el continente. El proceso de canonizar lo realizaba el musicólogo, el compositor o, más raramente, los intérpretes, de manera generalmente disociada. Con la conformación de una cultura de masas de base industrial en la década de los 50, característica de la así llamada modernidad latinoamericana, y el desarrollo masivo de la creatividad en la pluralidad de tradiciones musicales cultivadas en el continente, la música de arte no constituye hoy día el único posible referente canónico. Por el contrario, los referentes canónicos en Chile y Latinoamérica están, en muchos casos, fuera de la música de arte. Esto plantea un desafío formidable a la musicología, el cual debe ser abordado mediante la convergencia disciplinaria intra y extra musicológica, además de la generación de una crítica musicológica, que sirva de base para la formulación del juicio de valor, en que se interactúen el musicólogo, el compositor y el intérpretemusic, within a tripartition involving the composer, his work and the impact of music upon an audience as a result of the social process of music comunication. For many years the music from Central Europe and its canon was considered in Latin America as the musical language par excellence. All other musics were valued by the yardstick of European art music. The canonizing was carried out by musicologists, composers or less frequently by performers, usually in a totally unrelated manner. With the establishment of a mass culture in the fifties, typical

  4. 低硬、低碱度水的再矿化对管道腐蚀的控制效果%Remineralization of Low Hardness and Low Alkalinity Water for Pipeline Corrosion Control

    Institute of Scientific and Technical Information of China (English)

    许仕荣; 赵伟; 王长平; 徐洪福

    2012-01-01

    The efficiencies of two remineralization alternatives for controlling pipeline corrosion caused by water with low hardness and low alkalinity in the Shenzhen area were investigated. One alternative dosed lime to raise the pH, and the other dosed lime and CO2. Dosing lime alone did not result in a significant improvement in the water' s corrosiveness, but dosing lime with CO2 was effective in controlling pipeline corrosion. The corrosion rates on A3 steel, galvanized steel, grey and nodular cast irons, compared to the rates in non-remineralized water, were reduced by 73. 3% , 70. 0% , 59. 7% and 67. 9% respectively when the alkalinity of remineralized water increased to 80 mg/L as CaCO3. The content of calcium carbonate in the corrosion products was more than 60% , and a calcium carbonate layer was formed on the pipe interior to protect against corrosion.%以深圳市的低硬、低碱度水为研究对象,考察单独投加石灰或CO2/石灰联用的两种再矿化工艺对管道腐蚀的控制效果.结果表明:当单独投加石灰提高水样的pH值时,水的腐蚀性并未有明显改变,而CO2/石灰再矿化工艺控制腐蚀的效果较明显.与未矿化的出厂水相比,当再矿化后水的碱度提高到80 mg/L(以CaC03计)时,对A3钢、镀锌钢、灰口铸铁和球墨铸铁的腐蚀速率分别降低了73.3%、70.0%、59.7%和67.9%,并且此时腐蚀产物中碳酸钙的含量超过了60%,能很好地形成碳酸钙保护膜以抑制管道腐蚀.

  5. Canonical Huffman code based full-text index

    Institute of Scientific and Technical Information of China (English)

    Yi Zhang; Zhili Pei; Jinhui Yang; Yanchun Liang

    2008-01-01

    Full-text indices are data structures that can be used to find any substring of a given string. Many full-text indices require space larger than the original string. In this paper, we introduce the canonical Huffman code to the wavelet tree of a string T[1...n]. Compared with Huffman code based wavelet tree, the memory space used to represent the shape of wavelet tree is not needed. In case of large alphabet, this part of memory is not negligible. The operations of wavelet tree are also simpler and more efficient due to the canonical Huffman code. Based on the resulting structure, the multi-key rank and select functions can be performed using at most nH0 + |X|(lglgn + lgn - lg|Σ|)+O(nH0) bits and in O(H0) time for average cases, where H0 is the zeroth order empirical entropy of T. In the end, we present an efficient construction algorithm for this index, which is on-line and linear.

  6. A non-canonical mismatch repair pathway in prokaryotes

    Science.gov (United States)

    Castañeda-García, A.; Prieto, A. I.; Rodríguez-Beltrán, J.; Alonso, N.; Cantillon, D.; Costas, C.; Pérez-Lago, L.; Zegeye, E. D.; Herranz, M.; Plociński, P.; Tonjum, T.; García de Viedma, D.; Paget, M.; Waddell, S. J.; Rojas, A. M.; Doherty, A. J.; Blázquez, J.

    2017-01-01

    Mismatch repair (MMR) is a near ubiquitous pathway, essential for the maintenance of genome stability. Members of the MutS and MutL protein families perform key steps in mismatch correction. Despite the major importance of this repair pathway, MutS–MutL are absent in almost all Actinobacteria and many Archaea. However, these organisms exhibit rates and spectra of spontaneous mutations similar to MMR-bearing species, suggesting the existence of an alternative to the canonical MutS–MutL-based MMR. Here we report that Mycobacterium smegmatis NucS/EndoMS, a putative endonuclease with no structural homology to known MMR factors, is required for mutation avoidance and anti-recombination, hallmarks of the canonical MMR. Furthermore, phenotypic analysis of naturally occurring polymorphic NucS in a M. smegmatis surrogate model, suggests the existence of M. tuberculosis mutator strains. The phylogenetic analysis of NucS indicates a complex evolutionary process leading to a disperse distribution pattern in prokaryotes. Together, these findings indicate that distinct pathways for MMR have evolved at least twice in nature. PMID:28128207

  7. Canonical quantum gravity on noncommutative space-time

    Science.gov (United States)

    Kober, Martin

    2015-06-01

    In this paper canonical quantum gravity on noncommutative space-time is considered. The corresponding generalized classical theory is formulated by using the Moyal star product, which enables the representation of the field quantities depending on noncommuting coordinates by generalized quantities depending on usual coordinates. But not only the classical theory has to be generalized in analogy to other field theories. Besides, the necessity arises to replace the commutator between the gravitational field operator and its canonical conjugated quantity by a corresponding generalized expression on noncommutative space-time. Accordingly the transition to the quantum theory has also to be performed in a generalized way and leads to extended representations of the quantum theoretical operators. If the generalized representations of the operators are inserted to the generalized constraints, one obtains the corresponding generalized quantum constraints including the Hamiltonian constraint as dynamical constraint. After considering quantum geometrodynamics under incorporation of a coupling to matter fields, the theory is transferred to the Ashtekar formalism. The holonomy representation of the gravitational field as it is used in loop quantum gravity opens the possibility to calculate the corresponding generalized area operator.

  8. Canonical force and electromagnetic geometrical phase in particle interference

    Energy Technology Data Exchange (ETDEWEB)

    Horsley, S A R; Babiker, M [Department of Physics, University of York, Heslington, York YO10 5DD (United Kingdom)

    2007-06-14

    We provide arguments which demonstrate that the Berry phase effects involving particle interference in the presence of external electric and magnetic fields-namely the Aharonov-Bohm (AB), Aharonov-Casher (AC) and the Roentgen (R) effects-cannot be unambiguously explained (as has been controversially argued) through the use of any classical mechanical force. In fact, in the three scenarios which we consider, the only means to reclaim the standard quantum mechanical results is to use the expressions for the force that fail to satisfy the necessary conditions of gauge invariance. Our arguments explain the foundation of the controversy and confirm the standard idea that the Berry phase effects in question are non-local phenomena which only arise in the application of quantum theory. We lay special emphasis on the use of the concept of a canonical force, this being the quantity which ensures the agreement between the classical and quantum formulations. It is shown that if the Aharonov-Bohm effect is interpreted as being due to a force, through the use of the Bohmian formulation of quantum mechanics, then this force is equal in magnitude to the canonical force.

  9. Canonical Sonic Hedgehog Signaling in Early Lung Development

    Directory of Open Access Journals (Sweden)

    Hugo Fernandes-Silva

    2017-03-01

    Full Text Available The canonical hedgehog (HH signaling pathway is of major importance during embryonic development. HH is a key regulatory morphogen of numerous cellular processes, namely, cell growth and survival, differentiation, migration, and tissue polarity. Overall, it is able to trigger tissue-specific responses that, ultimately, contribute to the formation of a fully functional organism. Of all three HH proteins, Sonic Hedgehog (SHH plays an essential role during lung development. In fact, abnormal levels of this secreted protein lead to severe foregut defects and lung hypoplasia. Canonical SHH signal transduction relies on the presence of transmembrane receptors, such as Patched1 and Smoothened, accessory proteins, as Hedgehog-interacting protein 1, and intracellular effector proteins, like GLI transcription factors. Altogether, this complex signaling machinery contributes to conveying SHH response. Pulmonary morphogenesis is deeply dependent on SHH and on its molecular interactions with other signaling pathways. In this review, the role of SHH in early stages of lung development, specifically in lung specification, primary bud formation, and branching morphogenesis is thoroughly reviewed.

  10. Havelock Ellis's literary criticism, canon formation, and the heterosexual Shakespeare.

    Science.gov (United States)

    Radel, Nicholas F

    2009-01-01

    Famous as the author of an early full-length scientific study of sexual inversion or homosexuality, English sexologist Havelock Ellis was also a literary critic responsible for initiating publication of the famous Mermaid Series of "The Best of Plays of the Old Dramatists" in the late-nineteenth century. Personally editing the first volume of plays by Christopher Marlowe and a later collection by tragedian John Ford, Ellis associated these playwrights here and in his scientific work, Sexual Inversion, with ideas about normative and so-called abnormal sexualities at the start of the twentieth century. Ellis, thus, helped give expression to a literary canon of early English dramatists in which modern, anachronistic ideas about sexual subjectivity play a part. While this article does not claim that Ellis was the necessary source for later criticism, it shows how, over the whole of the twentieth century, Shakespeare's priority in the literary canon came to be posited at least in part on his apparent sexual normality in contrast with a supposedly homosexual Christopher Marlowe and other playwrights such as Ford or Francis Beaumont and John Fletcher associated with varying degrees of sexual difference.

  11. The non-canonical functions of the heme oxygenases.

    Science.gov (United States)

    Vanella, Luca; Barbagallo, Ignazio; Tibullo, Daniele; Forte, Stefano; Zappalà, Agata; Li Volti, Giovanni

    2016-10-18

    Heme oxygenase (HO) isoforms catalyze the conversion of heme to carbon monoxide (CO) and biliverdin with a concurrent release of iron, which can drive the synthesis of ferritin for iron sequestration. Most of the studies so far were directed at evaluating the protective effect of these enzymes because of their ability to generate antioxidant and antiapoptotic molecules such as CO and bilirubin. Recent evidences are suggesting that HO may possess other important physiological functions, which are not related to its enzymatic activity and for which we would like to introduce for the first time the term "non canonical functions". Recent evidence suggest that both HO isoforms may form protein-protein interactions (i.e. cytochrome P450, adiponectin, CD91) thus serving as chaperone-like protein. In addition, truncated HO-1 isoform was localized in the nuclear compartment under certain experimental conditions (i.e. excitotoxicity, hypoxia) regulating the activity of important nuclear transcription factors (i.e. Nrf2) and DNA repair. In the present review, we discuss three potential signaling mechanisms that we refer to as the non-canonical functions of the HO isoforms: protein-protein interaction, intracellular compartmentalization, and extracellular secretion. The aim of the present review is to describe each of this mechanism and all the aspects warranting additional studies in order to unravel all the functions of the HO system.

  12. Geometric integrator for simulations in the canonical ensemble

    Science.gov (United States)

    Tapias, Diego; Sanders, David P.; Bravetti, Alessandro

    2016-08-01

    We introduce a geometric integrator for molecular dynamics simulations of physical systems in the canonical ensemble that preserves the invariant distribution in equations arising from the density dynamics algorithm, with any possible type of thermostat. Our integrator thus constitutes a unified framework that allows the study and comparison of different thermostats and of their influence on the equilibrium and non-equilibrium (thermo-)dynamic properties of a system. To show the validity and the generality of the integrator, we implement it with a second-order, time-reversible method and apply it to the simulation of a Lennard-Jones system with three different thermostats, obtaining good conservation of the geometrical properties and recovering the expected thermodynamic results. Moreover, to show the advantage of our geometric integrator over a non-geometric one, we compare the results with those obtained by using the non-geometric Gear integrator, which is frequently used to perform simulations in the canonical ensemble. The non-geometric integrator induces a drift in the invariant quantity, while our integrator has no such drift, thus ensuring that the system is effectively sampling the correct ensemble.

  13. Canonical RNA Pseudoknot Structures with Arc Length $\\geq 4$

    CERN Document Server

    Reidys, Christian M; Zhao, Albus Y Y

    2010-01-01

    In this paper, we compute the generating function of the arguably most important target class of folding algorithms into RNA pseudoknot structures. This class consists of $k$-noncrossing, canonical RNA structures having minimum arc length four and generalizes directly the canonical secondary structures, studied by Schuster {\\it et al.} \\cite{Schuster:98}. The combinatorics of this class is important since, in analogy to the case of secondary structures, generic properties of genotype phenotype maps into RNA pseudoknot structures, like shape space covering \\cite{Schuster:94} and neutral networks \\cite{Reidys:97a} are a result of the combinatorics and not of the particulars of energy parameters. Let ${\\sf Q}_k(n)$ denote the number of these structures over $n$ vertices. We derive exact enumeration results as well as the asymptotic formula ${\\sf Q}_k(n)\\sim c_k n^{-(k-1)^2-\\frac{k-1}{2}}(\\gamma_{\\theta,k})^{-n}$ for $k=3, ..., 9$ and derive a new proof of Schuster's result, ${\\sf Q}_2(n)\\sim 1.4848\\, n^{-3/2}\\,1...

  14. Improving the sampling efficiency of the Grand Canonical Simulated Quenching approach

    Energy Technology Data Exchange (ETDEWEB)

    Perez, Danny [Los Alamos National Laboratory; Vernon, Louis J. [Los Alamos National Laboratory

    2012-04-04

    attempted to equilibrate the chemical potential between two cells and hence allow for the calculation of coexistence curves, exploit the same idea: particle insertion (or exchange) is attempted and accepted with a Metropolis-like rule that depends exponentially on the energy change upon insertion. A well known limitation of this kind of approach is that the probability of accepting such a move decreases extremely rapidly with increasing density, due to the extremely large short-range repulsion between atoms. In response to these difficulties it became apparent that a solution to the problem might be to avoid abrupt insertions but instead to proceed gradually, so as to allow the system to react and make way for the incoming particle. In this view of things, the 'occupation' of a certain atomic site can be viewed as a continuous variable, ranging between 0 and 1, representing 'how much' of the particle is present at any given time. These ideas proved ideal in Molecular Dynamics (MD) settings because equations of motions for these occupation variables can sometimes be obtained. For example, in the case of Grand Canonical Molecular Dynamics [Cagin91], one special particle is allowed to have a fractional occupation. This can lead to either its destruction (occupation = 0) or its complex creation (occupation = 1) so as to enforce a given chemical potential. These approaches proved useful, but mostly in the liquid state where the probability of successfully inserting a new particle is sufficiently high. At higher densities, convergence proved to be hampered by very inefficient sampling. In this work, we explore the use of a related MD-based grand canonical technique, the Grand Canonical Simulated Quenching (GCSQ) of Phillpot and Rickman [Phillpot92,Phillpot94], and explore its application to the grand canonical sampling of solid state systems. We show that, in conjunction with advanced sampling techniques, GCSQ can be a useful tool to sample conformations of

  15. Engineering Stable Discrete-Time Quantum Dynamics via a Canonical QR Decomposition

    CERN Document Server

    Bolognani, Saverio

    2009-01-01

    We analyze the asymptotic behavior of discrete-time, Markovian quantum systems with respect to a subspace of interest. Global asymptotic stability of subspaces is relevant to quantum information processing, in particular for initializing the system in pure states or subspace codes. We provide a linear-algebraic characterization of the dynamical properties leading to invariance and attractivity of a given quantum subspace. We then construct a design algorithm for discrete-time feedback control that allows to stabilize a target subspace, proving that if the control problem is feasible, then the algorithm returns an effective control choice. In order to prove this result, a canonical QR matrix decomposition is derived, and also used to establish the control scheme potential for the simulation of open-system dynamics.

  16. Canonical finite element method for solving nonconvex variational problems to post buckling beam problem

    Science.gov (United States)

    Ali, Elaf Jaafar; Gao, David Yang

    2016-10-01

    The goal of this paper is to solve the post buckling phenomena of a large deformed elastic beam by a canonical dual mixed finite element method (CD-FEM). The total potential energy of this beam is a nonconvex functional which can be used to model both pre-and post-buckling problems. Different types of dual stress interpolations are used in order to verify the triality theory. Applications are illustrated with different boundary conditions and external loads by using semi-definite programming (SDP) algorithm. The results show that the global minimum of the total potential energy is stable buckled configuration, the local maximum solution leads to the unbuckled state, and both of these two solutions are numerically stable. While the local minimum is unstable buckled configuration and very sensitive to both stress interpolations and the external loads.

  17. Output feedback stabilization for stochastic nonlinear systems in observer canonical form with stable zero-dynamics

    Institute of Scientific and Technical Information of China (English)

    潘子刚; 刘允刚; 施颂椒

    2001-01-01

    In this paper, we study the problem of output feedback stabilization for stochastic nonlinear systems. We consider a class of stochastic nonlinear systems in observer canonical form with stable zero-dynamics. We introduce a sequence of state transformations that transform the system into a lower triangular structure that is amenable for integrator backstepping design. Then we design the output-feedback controller and prove that the closed-loop system is bounded in probability. Furthermore, when the disturbance vector field vanishes at the origin, the closed-loop system is asymptotically stable in the large. With special care, the controller preserves the equilibrium of the nonlinear system. An example is included to illustrate the theoretical findings.

  18. Thermalization and Canonical Typicality in Translation-Invariant Quantum Lattice Systems

    Science.gov (United States)

    Müller, Markus P.; Adlam, Emily; Masanes, Lluís; Wiebe, Nathan

    2015-12-01

    It has previously been suggested that small subsystems of closed quantum systems thermalize under some assumptions; however, this has been rigorously shown so far only for systems with very weak interaction between subsystems. In this work, we give rigorous analytic results on thermalization for translation-invariant quantum lattice systems with finite-range interaction of arbitrary strength, in all cases where there is a unique equilibrium state at the corresponding temperature. We clarify the physical picture by showing that subsystems relax towards the reduction of the global Gibbs state, not the local Gibbs state, if the initial state has close to maximal population entropy and certain non-degeneracy conditions on the spectrumare satisfied.Moreover,we showthat almost all pure states with support on a small energy window are locally thermal in the sense of canonical typicality. We derive our results from a statement on equivalence of ensembles, generalizing earlier results by Lima, and give numerical and analytic finite size bounds, relating the Ising model to the finite de Finetti theorem. Furthermore, we prove that global energy eigenstates are locally close to diagonal in the local energy eigenbasis, which constitutes a part of the eigenstate thermalization hypothesis that is valid regardless of the integrability of the model.

  19. Biodegradation of tetramethylammonium hydroxide (TMAH) in completely autotrophic nitrogen removal over nitrite (CANON) process.

    Science.gov (United States)

    Chen, Shen-Yi; Lu, Li-An; Lin, Jih-Gaw

    2016-06-01

    This study conducted a completely autotrophic nitrogen removal over nitrite (CANON) process in a continuous anoxic upflow bioreactor to treat synthetic wastewater with TMAH (tetramethylammonium hydroxide) ranging from 200 to 1000mg/L. The intermediates were analyzed for understanding the metabolic pathway of TMAH biodegradation in CANON process. In addition, (15)N-labeled TMAH was used as the substrate in a batch anoxic bioreactor to confirm that TMAH was converted to nitrogen gas in CANON process. The results indicated that TMAH was almost completely biodegraded in CANON system at different influent TMAH concentrations of 200, 500, and 1000mg/L. The average removal efficiencies of total nitrogen were higher than 90% during the experiments. Trimethylamine (TMA) and methylamine (MA) were found to be the main biodegradation intermediates of TMAH in CANON process. The production of nitrogen gas with (15)N-labeled during the batch anaerobic bioreactor indicated that CANON process successfully converted TMAH into nitrogen gas.

  20. Canonical and Non-Canonical Aspects of JAK–STAT Signaling: Lessons from Interferons for Cytokine Responses

    Science.gov (United States)

    Majoros, Andrea; Platanitis, Ekaterini; Kernbauer-Hölzl, Elisabeth; Rosebrock, Felix; Müller, Mathias; Decker, Thomas

    2017-01-01

    Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signal transduction mediates cytokine responses. Canonical signaling is based on STAT tyrosine phosphorylation by activated JAKs. Downstream of interferon (IFN) receptors, activated JAKs cause the formation of the transcription factors IFN-stimulated gene factor 3 (ISGF3), a heterotrimer of STAT1, STAT2 and interferon regulatory factor 9 (IRF9) subunits, and gamma interferon-activated factor (GAF), a STAT1 homodimer. In recent years, several deviations from this paradigm were reported. These include kinase-independent JAK functions as well as extra- and intranuclear activities of U-STATs without phosphotyrosines. Additionally, transcriptional control by STAT complexes resembling neither GAF nor ISGF3 contributes to transcriptome changes in IFN-treated cells. Our review summarizes the contribution of non-canonical JAK–STAT signaling to the innate antimicrobial immunity imparted by IFN. Moreover, we touch upon functions of IFN pathway proteins beyond the IFN response. These include metabolic functions of IRF9 as well as the regulation of natural killer cell activity by kinase-dead TYK2 and different phosphorylation isoforms of STAT1. PMID:28184222

  1. An algorithm and its application for obtaining some kind of infinite-dimensional Hamiltonian canonical formulation

    Institute of Scientific and Technical Information of China (English)

    Ren Wen-Xiu; Alatancang

    2007-01-01

    Using factorization viewpoint of differential operator, this paper discusses how ti transform a nonlinear evolution equation to infinite-dimensional Hamiltonian linear canonical formulation. It proves a sufficient condition of canonical factorization of operator, and provides a kind of mechanical algebraic method to achieve canonical '(δ)/(δ)x'-type expression, correspondingly. Then three examples are given, which show the application of the obtained algorithm. Thus a novel idea for inverse problem can be derived fegibly.

  2. Transcriptional oscillation of canonical clock genes in mouse peripheral tissues

    Directory of Open Access Journals (Sweden)

    Nakahata Yasukazu

    2004-10-01

    Full Text Available Abstract Background The circadian rhythm of about 24 hours is a fundamental physiological function observed in almost all organisms from prokaryotes to humans. Identification of clock genes has allowed us to study the molecular bases for circadian behaviors and temporal physiological processes such as hormonal secretion, and has prompted the idea that molecular clocks reside not only in a central pacemaker, the suprachiasmatic nuclei (SCN of hypothalamus in mammals, but also in peripheral tissues, even in immortalized cells. Furthermore, previous molecular dissection revealed that the mechanism of circadian oscillation at a molecular level is based on transcriptional regulation of clock and clock-controlled genes. Results We systematically analyzed the mRNA expression of clock and clock-controlled genes in mouse peripheral tissues. Eight genes (mBmal1, mNpas2, mRev-erbα, mDbp, mRev-erbβ, mPer3, mPer1 and mPer2; given in the temporal order of the rhythm peak showed robust circadian expressions of mRNAs in all tissues except testis, suggesting that these genes are core molecules of the molecular biological clock. The bioinformatics analysis revealed that these genes have one or a combination of 3 transcriptional elements (RORE, DBPE, and E-box, which are conserved among human, mouse, and rat genome sequences, and indicated that these 3 elements may be responsible for the biological timing of expression of canonical clock genes. Conclusions The observation of oscillatory profiles of canonical clock genes is not only useful for physiological and pathological examination of the circadian clock in various organs but also important for systematic understanding of transcriptional regulation on a genome-wide basis. Our finding of the oscillatory expression of canonical clock genes with a temporal order provides us an interesting hypothesis, that cyclic timing of all clock and clock-controlled genes may be dependent on several transcriptional elements

  3. The quantum general linear supergroup, canonical bases and Kazhdan-Lusztig polynomials

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Canonical bases of the tensor powers of the natural Uq(glm|n)-module V are constructed by adapting the work of Frenkel, Khovanov and Kirrilov to the quantum supergroup setting. This result is generalized in several directions. We first construct the canonical bases of the Z2-graded symmetric algebra of V and tensor powers of this superalgebra; then construct canonical bases for the superalgebra Oq(Mm|n) of a quantum (m, n) × (m, n)-supermatrix; and finally deduce from the latter result the canonical basis of every irreducible tensor module for Uq(glm|n) by applying a quantum analogue of the Borel-Weil construction.

  4. Controlled levels of canonical Wnt signaling are required for neural crest migration.

    Science.gov (United States)

    Maj, Ewa; Künneke, Lutz; Loresch, Elisabeth; Grund, Anita; Melchert, Juliane; Pieler, Tomas; Aspelmeier, Timo; Borchers, Annette

    2016-09-01

    Canonical Wnt signaling plays a dominant role in the development of the neural crest (NC), a highly migratory cell population that generates a vast array of cell types. Canonical Wnt signaling is required for NC induction as well as differentiation, however its role in NC migration remains largely unknown. Analyzing nuclear localization of β-catenin as readout for canonical Wnt activity, we detect nuclear β-catenin in premigratory but not migratory Xenopus NC cells suggesting that canonical Wnt activity has to decrease to basal levels to enable NC migration. To define a possible function of canonical Wnt signaling in Xenopus NC migration, canonical Wnt signaling was modulated at different time points after NC induction. This was accomplished using either chemical modulators affecting β-catenin stability or inducible glucocorticoid fusion constructs of Lef/Tcf transcription factors. In vivo analysis of NC migration by whole mount in situ hybridization demonstrates that ectopic activation of canonical Wnt signaling inhibits cranial NC migration. Further, NC transplantation experiments confirm that this effect is tissue-autonomous. In addition, live-cell imaging in combination with biophysical data analysis of explanted NC cells confirms the in vivo findings and demonstrates that modulation of canonical Wnt signaling affects the ability of NC cells to perform single cell migration. Thus, our data support the hypothesis that canonical Wnt signaling needs to be tightly controlled to enable migration of NC cells.

  5. Canonical Group Quantization, Rotation Generators and Quantum Indistinguishability

    CERN Document Server

    Benavides, C

    2008-01-01

    Using the method of canonical group quantization, we construct the angular momentum operators associated to configuration spaces with the topology of (i) a sphere and (ii) a projective plane. In the first case, the obtained angular momentum operators are the quantum version of Poincare's vector, i.e., the physically correct angular momentum operators for an electron coupled to the field of a magnetic monopole. In the second case, the obtained operators represent the angular momentum operators of a system of two indistinguishable spin zero quantum particles in three spatial dimensions. We explicitly show how our formalism relates to the one developed by Berry and Robbins. The relevance of the proposed formalism for an advance in our understanding of the spin-statistics connection in non-relativistic quantum mechanics is discussed.

  6. Geometric integrator for simulations in the canonical ensemble

    CERN Document Server

    Tapias, Diego; Bravetti, Alessandro

    2016-01-01

    In this work we introduce a geometric integrator for molecular dynamics simulations of physical systems in the canonical ensemble. In particular, we consider the equations arising from the so-called density dynamics algorithm with any possible type of thermostat and provide an integrator that preserves the invariant distribution. Our integrator thus constitutes a unified framework that allows the study and comparison of different thermostats and of their influence on the equilibrium and non-equilibrium (thermo-)dynamic properties of the system. To show the validity and the generality of the integrator, we implement it with a second-order, time-reversible method and apply it to the simulation of a Lennard-Jones system with three different thermostats, obtaining good conservation of the geometrical properties and recovering the expected thermodynamic results.

  7. Paul Weiss and the genesis of canonical quantization

    Science.gov (United States)

    Rickles, Dean; Blum, Alexander

    2015-12-01

    This paper describes the life and work of a figure who, we argue, was of primary importance during the early years of field quantisation and (albeit more indirectly) quantum gravity. A student of Dirac and Born, he was interned in Canada during the second world war as an enemy alien and after his release never seemed to regain a good foothold in physics, identifying thereafter as a mathematician. He developed a general method of quantizing (linear and non-linear) field theories based on the parameters labelling an arbitrary hypersurface. This method (the `parameter formalism' often attributed to Dirac), though later discarded, was employed (and viewed at the time as an extremely important tool) by the leading figures associated with canonical quantum gravity: Dirac, Pirani and Schild, Bergmann, DeWitt, and others. We argue that he deserves wider recognition for this and other innovations.

  8. Garcilaso y Cervantes en la perspectiva del canon

    Directory of Open Access Journals (Sweden)

    Pablo Gálvez

    2015-06-01

    Full Text Available Este ensayo examina de modo sucinto la relación entre la obra de Miguel de Cervantes, en especial el Quijote, y la poesía de Garcilaso de la Vega en el horizonte de los valores consagrados en el canon literario de los Siglos de Oro. Para ello, primeramente se ofrece una breve semblanza biográfica e intelectual que busca establecer similitudes entre ambos autores; en segundo lugar, el texto registra diversas apariciones o “señales” garcilasianas en las páginas de la novela en sus dos partes (1605 y 1615 y las comenta con una visión al mismo tiempo crítica e histórica. El trabajo procura hacer una contribución sobre modos nuevos de analizar la tradición literaria y presta la mayor atención a las ideas cervantinas sobre la poesía.

  9. Field Theories on Canonical and Lie-Algebra Noncommutative Spacetimes

    CERN Document Server

    Amelino-Camelia, G; Doplicher, L; Amelino-Camelia, Giovanni; Arzano, Michele; Doplicher, Luisa

    2002-01-01

    Field theories on canonical noncommutative spacetimes, which are being studied also in connection with string theory, and on $\\kappa$-Minkowski spacetime, which is a popular example of Lie-algebra noncommutative spacetime, can be naturally constructed by introducing a suitable generating functional for Green functions in energy-momentum space. Direct reference to a star product is not necessary. It is sufficient to make use of the simple properties that the Fourier transform preserves in these spacetimes and establish the rules for products of wave exponentials that are dictated by the non-commutativity of the coordinates. The approach also provides an elementary description of "planar" and "non-planar" Feynman diagrams. We also comment on the rich phenomenology emerging from the analysis of these theories.

  10. Field Theories on Canonical and Lie-Algebra Noncommutative Spacetimes

    Science.gov (United States)

    Amelino-Camelia, G.; Arzano, M.; Doplicher, L.

    2003-01-01

    Field theories on canonical noncommutative spacetimes, which are being studied also in connection with string theory, and on k-Minkowski spacetime, which is a popular example of Lie-algebra noncommutative spacetime, can be naturally constructed by introducing a suitable generating functional for Green functions in energy-momentum space. Direct reference to a star product is not necessary. It is sufficient to make use of the simple properties that the Fourier transform preserves in these spacetimes and establish the rules for products of wave exponentials that are dictated by the non-commutativity of the coordinates. The approach also provides an elementary description of "planar" and "non-planar" Feynman diagrams. We also comment on the rich phenomenology emerging from the analysis of these theories.

  11. New Inequalities and Uncertainty Relations on Linear Canonical Transform Revisit

    Directory of Open Access Journals (Sweden)

    Xu Guanlei

    2009-01-01

    Full Text Available The uncertainty principle plays an important role in mathematics, physics, signal processing, and so on. Firstly, based on definition of the linear canonical transform (LCT and the traditional Pitt's inequality, one novel Pitt's inequality in the LCT domains is obtained, which is connected with the LCT parameters a and b. Then one novel logarithmic uncertainty principle is derived from this novel Pitt's inequality in the LCT domains, which is associated with parameters of the two LCTs. Secondly, from the relation between the original function and LCT, one entropic uncertainty principle and one Heisenberg's uncertainty principle in the LCT domains are derived, which are associated with the LCT parameters a and b. The reason why the three lower bounds are only associated with LCT parameters a and b and independent of c and d is presented. The results show it is possible that the bounds tend to zeros.

  12. Statistical mechanics of neocortical interactions Canonical momenta indicators of electroencephalography

    CERN Document Server

    Ingber, L

    1997-01-01

    A series of papers has developed a statistical mechanics of neocortical interactions (SMNI), deriving aggregate behavior of experimentally observed columns of neurons from statistical electrical-chemical properties of synaptic interactions. While not useful to yield insights at the single neuron level, SMNI has demonstrated its capability in describing large-scale properties of short-term memory and electroencephalographic (EEG) systematics. The necessity of including nonlinear and stochastic structures in this development has been stressed. Sets of EEG and evoked potential data were fit, collected to investigate genetic predispositions to alcoholism and to extract brain signatures of short-term memory. Adaptive Simulated Annealing (ASA), a global optimization algorithm, was used to perform maximum likelihood fits of Lagrangians defined by path integrals of multivariate conditional probabilities. Canonical momenta indicators (CMI) are thereby derived for individual's EEG data. The CMI give better signal recog...

  13. A Graphical representation of the grand canonical partition function

    CERN Document Server

    Smii, Boubaker

    2010-01-01

    In this paper we consider a stochastic partial differential equation defined on a Lattice $L_\\delta$ with coefficients of non-linearity with degree $p$. An analytic solution in the sense of formal power series is given. The obtained series can be re-expressed in terms of rooted trees with two types of leaves. Under the use of the so-called Cole-Hopf transformation and for the particular case $p=2$, one thus get the generalized Burger equation. A graphical representation of the solution and its logarithm is done in this paper. A discussion of the summability of the previous formal solutions is done in this paper using Borel sum. A graphical calculus of the correlation function is given. The special case when the noise is of L\\'evy type gives a simplified representations of the solution of the generalized Burger equation. From the previous results we recall a graphical representation of the grand canonical partition function.

  14. Canonical ensemble in non-extensive statistical mechanics, q > 1

    Science.gov (United States)

    Ruseckas, Julius

    2016-09-01

    The non-extensive statistical mechanics has been used to describe a variety of complex systems. The maximization of entropy, often used to introduce the non-extensive statistical mechanics, is a formal procedure and does not easily lead to physical insight. In this article we investigate the canonical ensemble in the non-extensive statistical mechanics by considering a small system interacting with a large reservoir via short-range forces and assuming equal probabilities for all available microstates. We concentrate on the situation when the reservoir is characterized by generalized entropy with non-extensivity parameter q > 1. We also investigate the problem of divergence in the non-extensive statistical mechanics occurring when q > 1 and show that there is a limit on the growth of the number of microstates of the system that is given by the same expression for all values of q.

  15. Linking covariant and canonical LQG II: Spin foam projector

    CERN Document Server

    Thiemann, Thomas

    2013-01-01

    In a seminal paper, Kaminski, Kisielowski an Lewandowski for the first time extended the definition of spin foam models to arbitrary boundary graphs. This is a prerequisite in order to make contact to the canonical formulation of Loop Quantum Gravity (LQG) and allows to investigate the question whether any of the presently considered spin foam models yield a rigging map for any of the presently defined Hamiltonian constraint operators. The KKL extension cannot be described in terms of Group Field Theory (GFT) since arbitrary foams are involved while GFT is tied to simplicial complexes. Therefore one has to define the sum over spin foams with given boundary spin networks in an independent fashion using natural axioms, most importantly a gluing property for 2-complexes. These axioms are motivated by the requirement that spin foam amplitudes should define a rigging map (physical inner product) induced by the Hamiltonian constraint. This is achieved by constructing a spin foam operator based on abstract 2-complex...

  16. Canon literario, educación y escritura femenina

    Directory of Open Access Journals (Sweden)

    Carmen Servén Díez

    2008-01-01

    Full Text Available La escasa presencia de mujeres en el canon literario habitualmente manejado se deriva de determinadas condiciones socio-históricas. La enseñanza de la Historia de la Literatura no consiste en repetir y transmitir una construcción heredada, sino en ajustar un repertorio de autores para inducir en nuestros estudiantes la curiosidad lectora y proponerles distintas versiones del mundo y de lo humano. La especial posición de las mujeres escritoras en el pasado, su peculiar forma de intervención en el diálogo social y en el mundo artístico, forman parte de las experiencias creativas a lo largo de la historia y deben ser objeto de revisión en clase, si queremos lograr una educación plural y una visión cabal de los hechos literarios. Necesitamos materiales didácticos adecuados a esta nueva perspectiva.

  17. Canonical momenta indicators of financial markets and neocortical EEG

    CERN Document Server

    Ingber, L

    1996-01-01

    A paradigm of statistical mechanics of financial markets (SMFM) is fit to multivariate financial markets using Adaptive Simulated Annealing (ASA), a global optimization algorithm, to perform maximum likelihood fits of Lagrangians defined by path integrals of multivariate conditional probabilities. Canonical momenta are thereby derived and used as technical indicators in a recursive ASA optimization process to tune trading rules. These trading rules are then used on out-of-sample data, to demonstrate that they can profit from the SMFM model, to illustrate that these markets are likely not efficient. This methodology can be extended to other systems, e.g., electroencephalography. This approach to complex systems emphasizes the utility of blending an intuitive and powerful mathematical-physics formalism to generate indicators which are used by AI-type rule-based models of management.

  18. Quasinormal modes and Regge poles of the canonical acoustic hole

    CERN Document Server

    Dolan, Sam R; Crispino, Luis C B

    2014-01-01

    We compute the quasinormal mode frequencies and Regge poles of the canonical acoustic hole (a black hole analogue), using three methods. First, we show how damped oscillations arise by evolving generic perturbations in the time domain using a simple finite-difference scheme. We use our results to estimate the fundamental QN frequencies of the low multipolar modes $l=1, 2, \\ldots$. Next, we apply an asymptotic method to obtain an expansion for the frequency in inverse powers of $l+1/2$ for low overtones. We test the expansion by comparing against our time-domain results, and (existing) WKB results. The expansion method is then extended to locate the Regge poles. Finally, to check the expansion of Regge poles we compute the spectrum numerically by direct integration in the frequency domain. We give a geometric interpretation of our results and comment on experimental verification.

  19. A Computer Program for a Canonical Problem in Underwater Shock

    Directory of Open Access Journals (Sweden)

    Thomas L. Geers

    1994-01-01

    Full Text Available Finite-element/boundary-element codes are widely used to analyze the response of marine structures to underwater explosions. An important step in verifying the correctness and accuracy of such codes is the comparison of code-generated results for canonical problems with corresponding analytical or semianalytical results. At the present time, such comparisons rely on hardcopy results presented in technical journals and reports. This article describes a computer program available from SAVIAC that produces user-selected numerical results for a step-wave-excited spherical shell submerged in and (optionally filled with an acoustic fluid. The method of solution employed in the program is based on classical expansion of the field quantities in generalized Fourier series in the meridional coordinate. Convergence of the series is enhanced by judicious application of modified Cesàro summation and partial closed-form solution.

  20. Absence of canonical active chromatin marks in developmentally regulated genes

    Science.gov (United States)

    Ruiz-Romero, Marina; Corominas, Montserrat; Guigó, Roderic

    2015-01-01

    The interplay of active and repressive histone modifications is assumed to play a key role in the regulation of gene expression. In contrast to this generally accepted view, we show that transcription of genes temporally regulated during fly and worm development occurs in the absence of canonically active histone modifications. Conversely, strong chromatin marking is related to transcriptional and post-transcriptional stability, an association that we also observe in mammals. Our results support a model in which chromatin marking is associated to stable production of RNA, while unmarked chromatin would permit rapid gene activation and de-activation during development. In this case, regulation by transcription factors would play a comparatively more important regulatory role. PMID:26280901

  1. Intersubject information mapping: revealing canonical representations of complex natural stimuli

    Directory of Open Access Journals (Sweden)

    Nikolaus Kriegeskorte

    2015-03-01

    Full Text Available Real-world time-continuous stimuli such as video promise greater naturalism for studies of brain function. However, modeling the stimulus variation is challenging and introduces a bias in favor of particular descriptive dimensions. Alternatively, we can look for brain regions whose signal is correlated between subjects, essentially using one subject to model another. Intersubject correlation mapping (ICM allows us to find brain regions driven in a canonical manner across subjects by a complex natural stimulus. However, it requires a direct voxel-to-voxel match between the spatiotemporal activity patterns and is thus only sensitive to common activations sufficiently extended to match up in Talairach space (or in an alternative, e.g. cortical-surface-based, common brain space. Here we introduce the more general approach of intersubject information mapping (IIM. For each brain region, IIM determines how much information is shared between the subjects' local spatiotemporal activity patterns. We estimate the intersubject mutual information using canonical correlation analysis applied to voxels within a spherical searchlight centered on each voxel in turn. The intersubject information estimate is invariant to linear transforms including spatial rearrangement of the voxels within the searchlight. This invariance to local encoding will be crucial in exploring fine-grained brain representations, which cannot be matched up in a common space and, more fundamentally, might be unique to each individual – like fingerprints. IIM yields a continuous brain map, which reflects intersubject information in fine-grained patterns. Performed on data from functional magnetic resonance imaging (fMRI of subjects viewing the same television show, IIM and ICM both highlighted sensory representations, including primary visual and auditory cortices. However, IIM revealed additional regions in higher association cortices, namely temporal pole and orbitofrontal cortex. These

  2. Red-Shifted Aequorin Variants Incorporating Non-Canonical Amino Acids: Applications in In Vivo Imaging.

    Directory of Open Access Journals (Sweden)

    Kristen M Grinstead

    Full Text Available The increased importance of in vivo diagnostics has posed new demands for imaging technologies. In that regard, there is a need for imaging molecules capable of expanding the applications of current state-of-the-art imaging in vivo diagnostics. To that end, there is a desire for new reporter molecules capable of providing strong signals, are non-toxic, and can be tailored to diagnose or monitor the progression of a number of diseases. Aequorin is a non-toxic photoprotein that can be used as a sensitive marker for bioluminescence in vivo imaging. The sensitivity of aequorin is due to the fact that bioluminescence is a rare phenomenon in nature and, therefore, it does not suffer from autofluorescence, which contributes to background emission. Emission of bioluminescence in the blue-region of the spectrum by aequorin only occurs when calcium, and its luciferin coelenterazine, are bound to the protein and trigger a biochemical reaction that results in light generation. It is this reaction that endows aequorin with unique characteristics, making it ideally suited for a number of applications in bioanalysis and imaging. Herein we report the site-specific incorporation of non-canonical or non-natural amino acids and several coelenterazine analogues, resulting in a catalog of 72 cysteine-free, aequorin variants which expand the potential applications of these photoproteins by providing several red-shifted mutants better suited to use in vivo. In vivo studies in mouse models using the transparent tissue of the eye confirmed the activity of the aequorin variants incorporating L-4-iodophehylalanine and L-4-methoxyphenylalanine after injection into the eye and topical addition of coelenterazine. The signal also remained localized within the eye. This is the first time that aequorin variants incorporating non-canonical amino acids have shown to be active in vivo and useful as reporters in bioluminescence imaging.

  3. Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension.

    Science.gov (United States)

    Uschner, Frank E; Ranabhat, Ganesh; Choi, Steve S; Granzow, Michaela; Klein, Sabine; Schierwagen, Robert; Raskopf, Esther; Gautsch, Sebastian; van der Ven, Peter F M; Fürst, Dieter O; Strassburg, Christian P; Sauerbruch, Tilman; Diehl, Anna Mae; Trebicka, Jonel

    2015-09-28

    Liver cirrhosis but also portal vein obstruction cause portal hypertension (PHT) and angiogenesis. This study investigated the differences of angiogenesis in cirrhotic and non-cirrhotic PHT with special emphasis on the canonical (Shh/Gli) and non-canonical (Shh/RhoA) hedgehog pathway. Cirrhotic (bile duct ligation/BDL; CCl4 intoxication) and non-cirrhotic (partial portal vein ligation/PPVL) rats received either atorvastatin (15 mg/kg; 7d) or control chow before sacrifice. Invasive hemodynamic measurement and Matrigel implantation assessed angiogenesis in vivo. Angiogenesis in vitro was analysed using migration and tube formation assay. In liver and vessel samples from animals and humans, transcript expression was analyzed using RT-PCR and protein expression using Western blot. Atorvastatin decreased portal pressure, shunt flow and angiogenesis in cirrhosis, whereas atorvastatin increased these parameters in PPVL rats. Non-canonical Hh was upregulated in experimental and human liver cirrhosis and was blunted by atorvastatin. Moreover, atorvastatin blocked the non-canonical Hh-pathway RhoA dependently in activated hepatic steallate cells (HSCs). Interestingly, hepatic and extrahepatic Hh-pathway was enhanced in PPVL rats, which resulted in increased angiogenesis. In summary, statins caused contrary effects in cirrhotic and non-cirrhotic portal hypertension. Atorvastatin inhibited the non-canonical Hh-pathway and angiogenesis in cirrhosis. In portal vein obstruction, statins enhanced the canonical Hh-pathway and aggravated PHT and angiogenesis.

  4. Creativity and Brain-Functioning in Product Development Engineers: A Canonical Correlation Analysis

    Science.gov (United States)

    Travis, Frederick; Lagrosen, Yvonne

    2014-01-01

    This study used canonical correlation analysis to explore the relation among scores on the Torrance test of figural and verbal creativity and demographic, psychological and physiological measures in Swedish product-development engineers. The first canonical variate included figural and verbal flexibility and originality as dependent measures and…

  5. Attenuation of the Squared Canonical Correlation Coefficient under Varying Estimates of Score Reliability

    Science.gov (United States)

    Wilson, Celia M.

    2010-01-01

    Research pertaining to the distortion of the squared canonical correlation coefficient has traditionally been limited to the effects of sampling error and associated correction formulas. The purpose of this study was to compare the degree of attenuation of the squared canonical correlation coefficient under varying conditions of score reliability.…

  6. Women Writers and the Canon. Focused Access to Selected Topics FAST Bib No. 72.

    Science.gov (United States)

    Hamilton, Melinda; Moke, Susan

    Reflecting educators' ongoing efforts to incorporate the female literary tradition into the canon that is commonly taught in high school and college classrooms, this bibliography derived from the ERIC database presents annotations of 21 journal articles and books concerning women writers and the canon published between 1984 and 1992. Sections of…

  7. Vocal Patterns in Infants with Autism Spectrum Disorder: Canonical Babbling Status and Vocalization Frequency

    Science.gov (United States)

    Patten, Elena; Belardi, Katie; Baranek, Grace T.; Watson, Linda R.; Labban, Jeffrey D.; Oller, D. Kimbrough

    2014-01-01

    Canonical babbling is a critical milestone for speech development and is usually well in place by 10 months. The possibility that infants with autism spectrum disorder (ASD) show late onset of canonical babbling has so far eluded evaluation. Rate of vocalization or "volubility" has also been suggested as possibly aberrant in infants with…

  8. Canonical osp(1,2) quantization of dynamical systems with constraints

    CERN Document Server

    Lavrov, P M; Oliveira, W; Lavrov, Petr M.; Neto, Jorge Ananias; Oliveira, Wilson

    1998-01-01

    The canonical version of osp(1,2) quantization is formulated for arbitrary dynamical systems with first-class constraints. The formalism generalizes the canonical scheme of extended BRST quantization proposed by Batalin, Lavrov and Tyutin a few years ago. The gauge dependence of Green's functions is studied. The Ward identities related to the osp(1,2) symmetry are derived.

  9. On the relationship between modifications to the Raychaudhuri equation and the canonical Hamiltonian structures

    Science.gov (United States)

    Singh, Parampreet; Soni, S. K.

    2016-06-01

    The problem of obtaining canonical Hamiltonian structures from the equations of motion, without any knowledge of the action, is studied in the context of the spatially flat Friedmann, ‘Robertson’, and Walker models. Modifications to the Raychaudhuri equation are implemented independently as quadratic and cubic terms of energy density without introducing additional degrees of freedom. Depending on their sign, modifications make gravity repulsive above a curvature scale for matter satisfying strong energy conditions, or more attractive than in the classical theory. The canonical structure of the modified theories is determined by demanding that the total Hamiltonian be a linear combination of gravity and matter Hamiltonians. In the quadratic repulsive case, the modified canonical phase space of gravity is a polymerized phase space with canonical momentum as inverse a trigonometric function of the Hubble rate; the canonical Hamiltonian can be identified with the effective Hamiltonian in loop quantum cosmology. The repulsive cubic modification results in a ‘generalized polymerized’ canonical phase space. Both the repulsive modifications are found to yield singularity avoidance. In contrast, the quadratic and cubic attractive modifications result in a canonical phase space in which canonical momentum is nontrigonometric and singularities persist. Our results hint at connections between the repulsive/attractive nature of modifications to gravity arising from the gravitational sector and polymerized/non polymerized gravitational phase space.

  10. Bach, Beethoven, Bourdieu: "Cultural Capital" and the Scholastic Canon in England's A-Level Examinations

    Science.gov (United States)

    Legg, Robert

    2012-01-01

    This article applies Bourdieu's notion of "cultural capital" to historical, documentary research which investigates the construction of a scholastic canon within England's A-level music examinations. A digest of the ways in which this canon evolved between 1951 and 1986 is presented in support of the idea that examiners' responses to…

  11. On the relationship between the modifications to the Raychaudhuri equation and the canonical Hamiltonian structures

    CERN Document Server

    Singh, Parampreet

    2015-01-01

    The problem of obtaining canonical Hamiltonian structures from the equations of motion is studied in the context of the spatially flat Friedmann-Robertson-Walker models. Modifications to Raychaudhuri equation are implemented independently as quadratic and cubic terms of energy density without introducing additional degrees of freedom. Depending on its sign, modifications make gravity repulsive above a curvature scale for matter satisfying strong energy condition, or more attractive than in the classical theory. Canonical structure of the modified theories is determined demanding that the total Hamiltonian be a linear combination of gravity and matter Hamiltonians. Both of the repulsive modifications are found to yield singularity avoidance. In the quadratic repulsive case, the modified canonical phase space of gravity is a polymerized phase space with canonical momentum as inverse trigonometric function of Hubble rate; the canonical Hamiltonian can be identified with the effective Hamiltonian in loop quantum ...

  12. Complete Hamiltonian analysis of cosmological perturbations at all orders II: non-canonical scalar field

    Science.gov (United States)

    Nandi, Debottam; Shankaranarayanan, S.

    2016-10-01

    In this work, we present a consistent Hamiltonian analysis of cosmological perturbations for generalized non-canonical scalar fields. In order to do so, we introduce a new phase-space variable that is uniquely defined for different non-canonical scalar fields. We also show that this is the simplest and efficient way of expressing the Hamiltonian. We extend the Hamiltonian approach of [1] to non-canonical scalar field and obtain an unique expression of speed of sound in terms of phase-space variable. In order to invert generalized phase-space Hamilton's equations to Euler-Lagrange equations of motion, we prescribe a general inversion formulae and show that our approach for non-canonical scalar field is consistent. We also obtain the third and fourth order interaction Hamiltonian for generalized non-canonical scalar fields and briefly discuss the extension of our method to generalized Galilean scalar fields.

  13. Complete Hamiltonian analysis of cosmological perturbations at all orders II: Non-canonical scalar field

    CERN Document Server

    Nandi, Debottam

    2016-01-01

    In this work, we present a consistent Hamiltonian analysis of cosmological perturbations for generalized non-canonical scalar fields. In order to do so, we introduce a new phase-space variable that is uniquely defined for different non-canonical scalar fields. We also show that this is the simplest and efficient way of expressing the Hamiltonian. We extend the Hamiltonian approach of [arXiv:1512.02539] to non-canonical scalar field and obtain a new definition of speed of sound in phase-space. In order to invert generalized phase-space Hamilton's equations to Euler-Lagrange equations of motion, we prescribe a general inversion formulae and show that our approach for non-canonical scalar field is consistent. We also obtain the third and fourth order interaction Hamiltonian for generalized non-canonical scalar fields and briefly discuss the extension of our method to generalized Galilean scalar fields.

  14. Canonical form of Nambu–Poisson bracket: A pedestrian approach

    Indian Academy of Sciences (India)

    S K Soni; Swami Nandan

    2011-12-01

    In the seventies, Nambu (Phys. Rev. D7, 2405 (1973)) proposed a new approach to classical dynamics based on an -dimensional Nambu–Poisson (NP) manifold replacing the primitive even-dimensional Poisson manifold and on –1 Hamiltonians in place of a single Hamiltonian. This approach has had many promoters including Bayen and Flato (Phys. Rev. D11, 3049 (1975)), Mukunda and Sudarshan (Phys. Rev. D13, 2846 (1976)), and Takhtajan (Comm. Math. Phys. 160, 295 (1994)) among others. While Nambu had originally considered = 3, the illustration of his ideas for = 4 and 6 was given by Chatterjee (Lett. Math. Phys. 36, 117 (1996)) who observed that the classical description of dynamical systems having dynamical symmetries is described elegantly by Nambu’s formalism of mechanics. However, his considerations do not quite yield the beautiful canonical form conjectured by Nambu himself for the -ary NP bracket. By making a judicious choice for the ‘extra constant of motion’ of namely, and , which are the orientation angles in Kepler problem and isotropic harmonic oscillator (HO) respectively, we show that the dynamical systems with dynamical symmetries can be recast in the beautiful form suggested by Nambu. We believe that the techniques used and the theorems suggested by us in this work are of general interest because of their involvement in the transition from Hamiltonian mechanics to Nambu mechanics.

  15. An optimization approach for fitting canonical tensor decompositions.

    Energy Technology Data Exchange (ETDEWEB)

    Dunlavy, Daniel M. (Sandia National Laboratories, Albuquerque, NM); Acar, Evrim; Kolda, Tamara Gibson

    2009-02-01

    Tensor decompositions are higher-order analogues of matrix decompositions and have proven to be powerful tools for data analysis. In particular, we are interested in the canonical tensor decomposition, otherwise known as the CANDECOMP/PARAFAC decomposition (CPD), which expresses a tensor as the sum of component rank-one tensors and is used in a multitude of applications such as chemometrics, signal processing, neuroscience, and web analysis. The task of computing the CPD, however, can be difficult. The typical approach is based on alternating least squares (ALS) optimization, which can be remarkably fast but is not very accurate. Previously, nonlinear least squares (NLS) methods have also been recommended; existing NLS methods are accurate but slow. In this paper, we propose the use of gradient-based optimization methods. We discuss the mathematical calculation of the derivatives and further show that they can be computed efficiently, at the same cost as one iteration of ALS. Computational experiments demonstrate that the gradient-based optimization methods are much more accurate than ALS and orders of magnitude faster than NLS.

  16. Canonical framework for multi-channel SAR-GMTI

    Institute of Scientific and Technical Information of China (English)

    Liu Congfeng; Liao Guisheng

    2008-01-01

    Synthetic aperture radar (SAR) systems have become an important tool for fine-resolution mapping and other remote sensing operations.The multi-channel SAR ground moving-target indication (GMTI) must process its data to produce not only the image of surveillance area but also the information of the ground moving-targets.The topic of moving-target detection in clutter has been extensively studied,and there are many methods that are used to detect moving targets,such as displaced phase center antenna (DPCA) method,along-track interfero-metric (ATI) phase,space-time adaptive processing (STAP),or some other metrics.A canonical framework is proposed that encompasses all the multi-channel SAR-GMT methods,namely,DPCA and ATI.The statistical test metric for multi-channel SAR-GMTI is established in a simple form,via the definition of the complex central Wishart distribution,to deduce the statistics of the test metric,and the probability distribution of the test metric for multichannel SAR-GMTI has the complex central Wishart distribution of 1×1 case,namely the x2 distribution.The theory foundation offers the possibility to construct the united multi-channel SAR-GMTI detector,and derives the constant false alarm rate (CFAR) detector tests for separating moving targets from clutter.

  17. Cuestionar el consenso: Ricardo Piglia reescribe el canon argentino

    Directory of Open Access Journals (Sweden)

    Ewa Kobylecka-Piwonska

    2013-02-01

    Full Text Available En el artículo, se investiga la cuestión del canon en la literatura argentina, según la interpretación que le da Ricardo Piglia. Primero, se distinguen las nociones de “canon” y “tradición”, usándose la primera para denotar una petrificada jerarquía de textos basada en los presuntos juicios de valor, y la segunda, un orden dinámico y productivo para la literatura actual. Luego, se aplica el término de “canon” en un contexto más amplio que el meramente literario, es decir, el lingüístico y el político, enfatizándose asimismo la relación que mantiene el estado con el  orden canónico. A este propósito, se echa mano de dos textos que Piglia dedica a la conferencia “Contra los poetas”, dictada en 1947 en Buenos Aires por el escritor polaco Witold Gombrowicz.

  18. Determination of the Reynolds stress in canonical flow geometries

    Science.gov (United States)

    Lee, T.-W.

    2016-11-01

    We present a new theoretical result for solving for the Reynolds stress in turbulent flows, and show how it works for canonical flow geometries: flow over a flat plate, channel flow, and axi-symmetric jets. The theory is based on fundamental physics of turbulence transport. Comparison of the current theoretical result with experimental and DNS (direct numerical simulation) data show good agreement, and various considerations of the results indicate that this is not a fortuitous coincidence, and point to radically new solutions for Reynolds stress. The theory leads to a closed-form formula for the Reynolds stress in terms of the root variables, such as the mean velocity, velocity gradient, turbulence kinetic energy and a viscous term. The form of the solution also provides insight on how the Reynolds stress is generated and distributed. This is not a modeling study, but a theoretical one based on physical principles although some of the nuances are still being examined. Details of the theory are submitted elsewhere, and also will be presented at the conference. The theoretical result for the Reynolds stress is compared with various experimental and DNS data. The agreement is nearly perfect at low Reynolds numbers, which gives some confidence that we have captured the true physics of turbulent transport, and that the results are not a fortuitous coincidence.

  19. Canon multifunction copier machines – now with onsite support!

    CERN Multimedia

    2013-01-01

    Following a retendering process in 2012, the IT Department is pleased to announce that leased multifunction copier machines are now covered by onsite support, provided by Canon technicians via the CERN Service Desk support system.   You can now contact the Service Desk regarding any problems or requests for toner: Telephone: 77777 Email: Service-Desk@cern.ch Please remember to quote the machine printer name and/or serial number (marked on the side of the machine). The following submission forms are available online: Report a failure with a printer or copier Request for network printer or copier installation or move Request toner/ink for my printer or copier The website below details the range of models available, all of which include print, photocopy and scan-to-mail functions as standard. These multifunction copier machines are leased subject to a monthly charge (minimum of 48 months) plus a “per click” charge to cover consumables (except staples), leaving you noth...

  20. Canonization in early twentieth-century Chinese art history’

    Directory of Open Access Journals (Sweden)

    Guo Hui

    2014-06-01

    Full Text Available Since the 1980s, the discussion of canons has been a dominant theme in the discipline of Western art history. Various concerns have emerged regarding ‘questions of artistic judgment’, ‘the history genesis of masterpieces’, ‘variations in taste’, ‘the social instruments of canonicity’, and ‘how canons disappear’. Western art historians have considered how the canon’s appearance in Western visual art embodies aesthetic, ideological, cultural, social, and symbolic values. In Chinese art history, the idea of a canon including masterpieces, important artists, and forms of art, dates back to the mid ninth century when Zhang Yanyuan wrote his painting history Record of Famous Painters of All the Dynasties. Faced with quite different political, economic, and social conditions amid the instability of the early twentieth century, Chinese scholars attempted to discover new canons for cultural orthodoxy and authority. Modern means for canonization, such as museums and exhibition displays, cultural and academic institutions, and massive art publications with image reproduction in good quality, brought the process up to an unprecedented speed. It is true that most of these means have comparable counterparts in pre-modern times. However, their enormous scope and overwhelming influence are far beyond the reach of their imperial counterparts. Through an inter-textual reading of the publications on Chinese art history in early twentieth-century China, this paper explores the transformation of canons in order to shed light on why and how canonical formation happened during the Republican period of China. Despite the diverse styles and strategies which Chinese writers used in their narratives, Chinese art historical books produced during the Republican period canonized and de-canonized artworks. In this paper, the discussion of these texts, with reference to other art historical works, comprises three parts: 1 canon formation of artistic forms

  1. Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca2+ in mitochondrial dynamics

    Science.gov (United States)

    Silva-Alvarez, Carmen; Arrázola, Macarena S.; Godoy, Juan A.; Ordenes, Daniela; Inestrosa, Nibaldo C.

    2013-01-01

    Alzheimer's disease (AD) is the most common type of age-related dementia. The disease is characterized by a progressive loss of cognitive abilities, severe neurodegeneration, synaptic loss and mitochondrial dysfunction. The Wnt signaling pathway participates in the development of the central nervous system and growing evidence indicates that Wnts also regulate the function of the adult nervous system. We report here, that indirect activation of canonical Wnt/β-catenin signaling using Bromoindirubin-30-Oxime (6-BIO), an inhibitor of glycogen synthase kinase-3β, protects hippocampal neurons from amyloid-β (Aβ) oligomers with the concomitant blockade of neuronal apoptosis. More importantly, activation with Wnt-5a, a non-canonical Wnt ligand, results in the modulation of mitochondrial dynamics, preventing the changes induced by Aβ oligomers (Aβo) in mitochondrial fission-fusion dynamics and modulates Bcl-2 increases induced by oligomers. The canonical Wnt-3a ligand neither the secreted Frizzled-Related Protein (sFRP), a Wnt scavenger, did not prevent these effects. In contrast, some of the Aβ oligomer effects were blocked by Ryanodine. We conclude that canonical Wnt/β-catenin signaling controls neuronal survival, and that non-canonical Wnt/Ca2+signaling modulates mitochondrial dysfunction. Since mitochondrial dysfunction is present in neurodegenerative diseases, the therapeutic possibilities of the activation of Wnt signaling are evident. PMID:23805073

  2. Unbiased Mitoproteome Analyses Confirm Non-canonical RNA, Expanded Codon Translations.

    Science.gov (United States)

    Seligmann, Hervé

    2016-01-01

    Proteomic MS/MS mass spectrometry detections are usually biased towards peptides cleaved by experimentally added digestion enzyme(s). Hence peptides resulting from spontaneous degradation and natural proteolysis usually remain undetected. Previous analyses of tryptic human proteome data (cleavage after K, R) detected non-canonical tryptic peptides translated according to tetra- and pentacodons (codons expanded by silent mono- and dinucleotides), and from transcripts systematically (a) deleting mono-, dinucleotides after trinucleotides (delRNAs), (b) exchanging nucleotides according to 23 bijective transformations. Nine symmetric and fourteen asymmetric nucleotide exchanges (X ↔ Y, e.g. A ↔ C; and X → Y → Z → X, e.g. A → C → G → A) produce swinger RNAs. Here unbiased reanalyses of these proteomic data detect preferentially non-canonical tryptic peptides despite assuming random cleavage. Unbiased analyses couldn't reconstruct experimental tryptic digestion if most detected non-canonical peptides were false positives. Detected non-tryptic non-canonical peptides map preferentially on corresponding, previously described non-canonical transcripts, as for tryptic non-canonical peptides. Hence unbiased analyses independently confirm previous trypsin-biased analyses that showed translations of del- and swinger RNA and expanded codons. Accounting for natural proteolysis completes trypsin-biased mitopeptidome analyses, independently confirms non-canonical transcriptions and translations.

  3. Unbiased Mitoproteome Analyses Confirm Non-canonical RNA, Expanded Codon Translations

    Directory of Open Access Journals (Sweden)

    Hervé Seligmann

    2016-01-01

    Full Text Available Proteomic MS/MS mass spectrometry detections are usually biased towards peptides cleaved by experimentally added digestion enzyme(s. Hence peptides resulting from spontaneous degradation and natural proteolysis usually remain undetected. Previous analyses of tryptic human proteome data (cleavage after K, R detected non-canonical tryptic peptides translated according to tetra- and pentacodons (codons expanded by silent mono- and dinucleotides, and from transcripts systematically (a deleting mono-, dinucleotides after trinucleotides (delRNAs, (b exchanging nucleotides according to 23 bijective transformations. Nine symmetric and fourteen asymmetric nucleotide exchanges (X ↔ Y, e.g. A ↔ C; and X → Y → Z → X, e.g. A → C → G → A produce swinger RNAs. Here unbiased reanalyses of these proteomic data detect preferentially non-canonical tryptic peptides despite assuming random cleavage. Unbiased analyses couldn't reconstruct experimental tryptic digestion if most detected non-canonical peptides were false positives. Detected non-tryptic non-canonical peptides map preferentially on corresponding, previously described non-canonical transcripts, as for tryptic non-canonical peptides. Hence unbiased analyses independently confirm previous trypsin-biased analyses that showed translations of del- and swinger RNA and expanded codons. Accounting for natural proteolysis completes trypsin-biased mitopeptidome analyses, independently confirms non-canonical transcriptions and translations.

  4. Canonical superenergy and angular supermomentum complexes in general relativity and some of their applications

    CERN Document Server

    Garecki, Janusz

    2016-01-01

    Many years ago we have introduced into general relativity, {\\bf GR}, the canonical superenergy tensors, $S_i^{~k}$, and the canonical angular supermomentum tensors, $S^{ikl}=(-)S^{kil}$, matter and gravitation. We have obtained these tensors by special averaging of the differences of the canonical energy-momentum and canonical angular momentum. The averaging was performed in Riemann normal coordinates, {\\bf RNC(P)}; {\\bf P} is beginning of these coordinates. About four years ago we have observed that these tensors can also be obtained in other, simpler way, by using the canonical superenergy and angular super momentum complexes, $_K S_i^{~k}$, and, $_K S~^{ikl}=(-)_K S^{kil}$, respectively. Such complexes can be introduced into {\\bf GR} in a natural way starting from canonical energy-momentum and angular momentum complexes. In this paper, at first, we define the canonical superenergy and angular supermomentum complexes in {\\bf GR} and then, we apply them to analyze of a closed system, {\\bf CS}, Trautman's rad...

  5. Canonical Force Distributions in Pairwise Interatomic Interactions from the Perspective of the Hellmann-Feynman Theorem.

    Science.gov (United States)

    Walton, Jay R; Rivera-Rivera, Luis A; Lucchese, Robert R; Bevan, John W

    2016-05-26

    Force-based canonical approaches have recently given a unified but different viewpoint on the nature of bonding in pairwise interatomic interactions. Differing molecular categories (covalent, ionic, van der Waals, hydrogen, and halogen bonding) of representative interatomic interactions with binding energies ranging from 1.01 to 1072.03 kJ/mol have been modeled canonically giving a rigorous semiempirical verification to high accuracy. However, the fundamental physical basis expected to provide the inherent characteristics of these canonical transformations has not yet been elucidated. Subsequently, it was shown through direct numerical differentiation of these potentials that their associated force curves have canonical shapes. However, this approach to analyzing force results in inherent loss of accuracy coming from numerical differentiation of the potentials. We now show that this serious obstruction can be avoided by directly demonstrating the canonical nature of force distributions from the perspective of the Hellmann-Feynman theorem. This requires only differentiation of explicitly known Coulombic potentials, and we discuss how this approach to canonical forces can be used to further explain the nature of chemical bonding in pairwise interatomic interactions. All parameter values used in the canonical transformation are determined through explicit physical based algorithms, and it does not require direct consideration of electron correlation effects.

  6. Relating the quantum mechanics of discrete systems to standard canonical quantum mechanics

    OpenAIRE

    Hooft, Gerard t

    2012-01-01

    Discrete quantum mechanics is here defined to be a quantum theory of wave functions defined on integers P_i and Q_i, while canonical quantum mechanics is assumed to be based on wave functions on the real numbers, R^n. We study reversible mappings from the position operators q_i and their quantum canonical operators p_i of a canonical theory, onto the discrete, commuting operators Q_i and P_i. In this paper we are particularly interested in harmonic oscillators. In the discrete system, these t...

  7. Linear response calculation using the canonical-basis TDHFB with a schematic pairing functional

    CERN Document Server

    Ebata, Shuichiro; Yabana, Kazuhiro

    2010-01-01

    A canonical-basis formulation of the time-dependent Hartree-Fock-Bogoliubov (TDHFB) theory is obtained with an approximation that the pair potential is assumed to be diagonal in the time-dependent canonical basis. The canonical-basis formulation significantly reduces the computational cost. We apply the method to linear-response calculations for even-even nuclei. E1 strength distributions for proton-rich Mg isotopes are systematically calculated. The calculation suggests strong Landau damping of giant dipole resonance for drip-line nuclei.

  8. Canonical pairs, Spatially Confined Motion and the Quantum Time of Arrival Problem

    CERN Document Server

    Galapon, E A

    2000-01-01

    It has always been believed that no self-adjoint and canonical time of arrival operator can be constructed within the confines of standard quantum mechanics. In this Letter we demonstrate the otherwise. We do so by pointing out that there is no a priori reason in demanding that canonical pairs form a system of imprimitivities. We then proceed to show that a class of self-adjoint and canonical time of arrival (TOA) operators can be constructed for a spatially confined free particle. And then discuss the relatiobship between the non-self-adjointess of the TOA operator for the unconfined particle and the self-adjointness of the confined one.

  9. Ground-water flow and quality near Canon City, Colorado

    Science.gov (United States)

    Hearne, G.A.; Litke, D.W.

    1987-01-01

    Water in aquifers that underlie the Lincoln Park area near Canon City, Colorado, contains measurable concentrations of chemical constituents that are similar to those in raffinate (liquid waste) produced by a nearby uranium ore processing mill. The objective of this study was to expand the existing geohydrologic data base by collecting additional geohydrologic and water quality, in order to refine the description of the geohydrologic and geochemical systems in the study area. Geohydrologic data were collected from nine tests wells drilled in the area between the U.S. Soil Conservation Service dam and Lincoln Park. Lithologic and geophysical logs of these wells indicated that the section of Vermejo Formation penetrated consisted of interbedded sandstone and shale. The sandstone beds had a small porosity and small hydraulic conductivity. Groundwater flow from the U.S. Soil Conservation Service dam to Lincoln Park seemed to be along an alluvium-filled channel in the irregular and relatively undescribed topography of the Vermejo Formation subcrop. North of the De Weese Dye Ditch, the alluvium becomes saturated and groundwater generally flows to the northeast. Water samples from 28 sites were collected and analyzed for major ions and trace elements; selected water samples also were analyzed for stable isotopes; samples were collected from wells near the uranium ore processing mill, from privately owned wells in Lincoln Park, and from the test wells drilled in the intervening area. Results from the quality assurance samples indicate that cross-contamination between samples from different wells was avoided and that the data are reliable. Water in the alluvial aquifer underlying Lincoln Park is mainly a calcium bicarbonate type. Small variations in the composition of water in the alluvial aquifer appears to result from a reaction of water leaking from the De Weese Dye Ditch with alluvial material. Upward leakage from underlying aquifers does not seem to be significant in

  10. Interpreting Canonical Correlation Analysis through Biplots of Structure Correlations and Weights.

    Science.gov (United States)

    ter Braak, Cajo J. F.

    1990-01-01

    Canonical weights and structure correlations are used to construct low dimensional views of the relationships between two sets of variables. These views, in the form of biplots, display familiar statistics: correlations between pairs of variables, and regression coefficients. (SLD)

  11. The quantum general linear supergroup,canonical bases and Kazhdan-Lusztig polynomials

    Institute of Scientific and Technical Information of China (English)

    ZHANG HeChun

    2009-01-01

    Canonical bases of the tensor powers of the natural Uq(glm|n)-module V are constructed by adapting the work of Frenkel,Khovanov and Kirrilov to the quantum supergroup setting.This result is generalized in several directions.We first construct the canonical bases of the Z2-graded symmetric algebra of V and tensor powers of this superalgebra;then construct canonical bases for the superalgebra Oq(Mm|n) of a quantum (m,n) x (m,n)-supermatrix;and finally deduce from the latter result the canonical basis of every irreducible tensor module for Uq(glm|n) by applying a quantum analogue of the Borel-Weil construction.

  12. A field theory approach to the evolution of canonical helicity and energy

    CERN Document Server

    You, Setthivoine

    2016-01-01

    A redefinition of the Lagrangian of a multi-particle system in fields reformulates the single-particle, kinetic, and fluid equations governing fluid and plasma dynamics as a single set of generalized Maxwell's equations and Ohm's law for canonical force-fields. The Lagrangian includes new terms representing the coupling between the motion of particle distributions, between distributions and electromagnetic fields, with relativistic contributions. The formulation shows that the concepts of self-organization and canonical helicity transport are applicable across single-particle, kinetic, and fluid regimes, at classical and relativistic scales. The theory gives the basis for comparing canonical helicity change to energy change in general systems. For example, in a fixed, isolated system subject to non-conservative forces, a species' canonical helicity changes less than total energy only if gradients in density or distribution function are shallow.

  13. A field theory approach to the evolution of canonical helicity and energy

    Science.gov (United States)

    You, S.

    2016-07-01

    A redefinition of the Lagrangian of a multi-particle system in fields reformulates the single-particle, kinetic, and fluid equations governing fluid and plasma dynamics as a single set of generalized Maxwell's equations and Ohm's law for canonical force-fields. The Lagrangian includes new terms representing the coupling between the motion of particle distributions, between distributions and electromagnetic fields, with relativistic contributions. The formulation shows that the concepts of self-organization and canonical helicity transport are applicable across single-particle, kinetic, and fluid regimes, at classical and relativistic scales. The theory gives the basis for comparing canonical helicity change to energy change in general systems. For example, in a fixed, isolated system subject to non-conservative forces, a species' canonical helicity changes less than total energy only if gradients in density or distribution function are shallow.

  14. One true threesome: Reconciling canon and fan desire in Star Trek: Voyager

    Directory of Open Access Journals (Sweden)

    Bridget Kies

    2011-09-01

    Full Text Available Fan-written stories that involve three-way relationships among the characters Tom Paris, Harry Kim, and B'Elanna Torres from Star Trek: Voyager capitalize on the homosocial bond between Paris and Kim and the canonical relationship between Paris and Torres to create a queer triangular relationship in which characterization, sexuality, and desire are all reoriented from the canon. Some of these stories relegate the nontraditional relationship to something approximating heteronormativity; in these instances, the story mirrors the canon in its often undesirable depiction of domesticity. In other stories, the triad moves away from dominant cultural expectations like marriage and children; in these stories, the triad seems to endure happily. The key to the stability of the erotic triangle therefore shifts the relationship or relationships away from the burden of hegemonic values, both in canon and in fan fiction.

  15. The use and origin of the (Old and New Testament as Christianity’s canon

    Directory of Open Access Journals (Sweden)

    Andries G. van Aarde

    2012-01-01

    Full Text Available This article explained the valuation of Christian believers with regard to the Christian Bible a ‘Holy Scripture’. In the article the notion ‘Scriptural authority’ was connected with an understanding of both the origin and use of the Christian canon. The article described the origin of the Bible in light of the supposition that the Bible functions as (1 book of theology, as well as (2 book of believers and as (3 book of the church. The article consisted of references to the role of the Old Testament and the New Testament canonical collections and the role of ecclesial synodal decisions. It also obtained a graphical overview of the history and dates of the New Testament writings as a canonical list. The article concluded with a reflection on the relevance for the use and authority of the Bible, seen from the perspective of the use and origin of the Bible as Christianity’s canon.

  16. The influence of canon law on ius commune in its formative period

    Directory of Open Access Journals (Sweden)

    Mehmeti Sami

    2015-12-01

    Full Text Available In the Medieval period, Roman law and canon law formed ius commune or the common European law. The similarity between Roman and canon law was that they used the same methods and the difference was that they relied on different authoritative texts. In their works canonists and civilists combined the ancient Greek achievements in philosophy with the Roman achievements in the field of law. Canonists were the first who carried out research on the distinctions between various legal sources and systematized them according to a hierarchical order. The Medieval civilists sought solutions in canon law for a large number of problems that Justinian’s Codification did not hinge on or did it only superficially. Solutions offered by canon law were accepted not only in the civil law of Continental Europe, but also in the English law.

  17. A Grand Canonical Monte Carlo Molecular Study of a Weak Polyampholyte

    KAUST Repository

    Jimenez, Arturo Martinez

    2016-05-01

    Over the last few decades, there has been an increasing interest in the study of charged polymers for applications such as desalination of water, flocculation, sewage treatment, and enhanced oil recovery. Polyelectrolyte chains containing both positively and negatively charged units (polyampholytes) have been recently studied as viscosity-control agents in enhanced oil recovery, and as entrapping macromolecules for protection and delayed release of enzymes in hydraulic fracturing. In this study we performed Monte Carlo molecular simulations in a grand canonical ensemble to study the behavior of a weak polyampholyte in a dilute regime. Weak polyampholytes have the ability to dissociate in a limited pH, which makes them interesting for applications that require a pH-triggerable response. The titration behaviors of diblock and random polyampholytes are simulated as a function of solvent quality, electrostatic strength, and salt concentration. For diblock polyampholyte chains in hydrophobic solvents, transition between tadpole-like and globule conformation occurs with variations in the solution pH. Random polyampholytes present extended, globule, and pearl-necklace conformations at different solvent conditions and pH values. At high ionic strength, electrostatic interactions in the polyampholytes become screened and the chains are mostly in globule state.

  18. Extended canonical Monte Carlo methods: Improving accuracy of microcanonical calculations using a reweighting technique

    Science.gov (United States)

    Velazquez, L.; Castro-Palacio, J. C.

    2015-03-01

    Velazquez and Curilef [J. Stat. Mech. (2010) P02002, 10.1088/1742-5468/2010/02/P02002; J. Stat. Mech. (2010) P04026, 10.1088/1742-5468/2010/04/P04026] have proposed a methodology to extend Monte Carlo algorithms that are based on canonical ensemble. According to our previous study, their proposal allows us to overcome slow sampling problems in systems that undergo any type of temperature-driven phase transition. After a comprehensive review about ideas and connections of this framework, we discuss the application of a reweighting technique to improve the accuracy of microcanonical calculations, specifically, the well-known multihistograms method of Ferrenberg and Swendsen [Phys. Rev. Lett. 63, 1195 (1989), 10.1103/PhysRevLett.63.1195]. As an example of application, we reconsider the study of the four-state Potts model on the square lattice L ×L with periodic boundary conditions. This analysis allows us to detect the existence of a very small latent heat per site qL during the occurrence of temperature-driven phase transition of this model, whose size dependence seems to follow a power law qL(L ) ∝(1/L ) z with exponent z ≃0 .26 ±0 .02. Discussed is the compatibility of these results with the continuous character of temperature-driven phase transition when L →+∞ .

  19. Canonical failure modes of real-time control systems: insights from cognitive theory

    Science.gov (United States)

    Wallace, Rodrick

    2016-04-01

    Newly developed necessary conditions statistical models from cognitive theory are applied to generalisation of the data-rate theorem for real-time control systems. Rather than graceful degradation under stress, automatons and man/machine cockpits appear prone to characteristic sudden failure under demanding fog-of-war conditions. Critical dysfunctions span a spectrum of phase transition analogues, ranging from a ground state of 'all targets are enemies' to more standard data-rate instabilities. Insidious pathologies also appear possible, akin to inattentional blindness consequent on overfocus on an expected pattern. Via no-free-lunch constraints, different equivalence classes of systems, having structure and function determined by 'market pressures', in a large sense, will be inherently unreliable under different but characteristic canonical stress landscapes, suggesting that deliberate induction of failure may often be relatively straightforward. Focusing on two recent military case histories, these results provide a caveat emptor against blind faith in the current path-dependent evolutionary trajectory of automation for critical real-time processes.

  20. A depression network of functionally connected regions discovered via multi-attribute canonical correlation graphs.

    Science.gov (United States)

    Kang, Jian; Bowman, F DuBois; Mayberg, Helen; Liu, Han

    2016-11-01

    To establish brain network properties associated with major depressive disorder (MDD) using resting-state functional magnetic resonance imaging (Rs-fMRI) data, we develop a multi-attribute graph model to construct a region-level functional connectivity network that uses all voxel level information. For each region pair, we define the strength of the connectivity as the kernel canonical correlation coefficient between voxels in the two regions; and we develop a permutation test to assess the statistical significance. We also construct a network based classifier for making predictions on the risk of MDD. We apply our method to Rs-fMRI data from 20 MDD patients and 20 healthy control subjects in the Predictors of Remission in Depression to Individual and Combined Treatments (PReDICT) study. Using this method, MDD patients can be distinguished from healthy control subjects based on significant differences in the strength of regional connectivity. We also demonstrate the performance of the proposed method using simulationstudies.

  1. Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site

    Science.gov (United States)

    Liu, Chuang; Perilla, Juan R.; Ning, Jiying; Lu, Manman; Hou, Guangjin; Ramalho, Ruben; Himes, Benjamin A.; Zhao, Gongpu; Bedwell, Gregory J.; Byeon, In-Ja; Ahn, Jinwoo; Gronenborn, Angela M.; Prevelige, Peter E.; Rousso, Itay; Aiken, Christopher; Polenova, Tatyana; Schulten, Klaus; Zhang, Peijun

    2016-03-01

    The host cell factor cyclophilin A (CypA) interacts directly with the HIV-1 capsid and regulates viral infectivity. Although the crystal structure of CypA in complex with the N-terminal domain of the HIV-1 capsid protein (CA) has been known for nearly two decades, how CypA interacts with the viral capsid and modulates HIV-1 infectivity remains unclear. We determined the cryoEM structure of CypA in complex with the assembled HIV-1 capsid at 8-Å resolution. The structure exhibits a distinct CypA-binding pattern in which CypA selectively bridges the two CA hexamers along the direction of highest curvature. EM-guided all-atom molecular dynamics simulations and solid-state NMR further reveal that the CypA-binding pattern is achieved by single-CypA molecules simultaneously interacting with two CA subunits, in different hexamers, through a previously uncharacterized non-canonical interface. These results provide new insights into how CypA stabilizes the HIV-1 capsid and is recruited to facilitate HIV-1 infection.

  2. A prototype symbolic model of canonical functional neuroanatomy of the motor system.

    Science.gov (United States)

    Talos, Ion-Florin; Rubin, Daniel L; Halle, Michael; Musen, Mark; Kikinis, Ron

    2008-04-01

    Recent advances in bioinformatics have opened entire new avenues for organizing, integrating and retrieving neuroscientific data, in a digital, machine-processable format, which can be at the same time understood by humans, using ontological, symbolic data representations. Declarative information stored in ontological format can be perused and maintained by domain experts, interpreted by machines, and serve as basis for a multitude of decision support, computerized simulation, data mining, and teaching applications. We have developed a prototype symbolic model of canonical neuroanatomy of the motor system. Our symbolic model is intended to support symbolic look up, logical inference and mathematical modeling by integrating descriptive, qualitative and quantitative functional neuroanatomical knowledge. Furthermore, we show how our approach can be extended to modeling impaired brain connectivity in disease states, such as common movement disorders. In developing our ontology, we adopted a disciplined modeling approach, relying on a set of declared principles, a high-level schema, Aristotelian definitions, and a frame-based authoring system. These features, along with the use of the Unified Medical Language System (UMLS) vocabulary, enable the alignment of our functional ontology with an existing comprehensive ontology of human anatomy, and thus allow for combining the structural and functional views of neuroanatomy for clinical decision support and neuroanatomy teaching applications. Although the scope of our current prototype ontology is limited to a particular functional system in the brain, it may be possible to adapt this approach for modeling other brain functional systems as well.

  3. Algebraic method for exact solution of canonical partition function in nuclear multifragmentation

    CERN Document Server

    Parvan, A S

    2002-01-01

    An algebraic method for the exact recursion formula for the calculation of canonical partition function of non-interaction finite systems of particles obeying Bose-Einstein, Fermi-Dirac, Maxwell-Boltzmann statistics or parastatistics is derived. A new exactly solvable multifragmentation model with baryon and electric charge conservation laws is developed. Recursion relations for this model are presented that allow exact calculation of canonical partition function for any statistics.

  4. Beyond or Below the Horizon? Sublime and Subliminal Challenges in Stewarding the Literary Canon

    DEFF Research Database (Denmark)

    Børch, Marianne

    2015-01-01

    The chapter discusses how certain texts may be excluded from canonical status by forms of resistance traceable to scholars' anxiety. Examples of such exiety are the 'fear of faith' and the 'fear of the literal.'......The chapter discusses how certain texts may be excluded from canonical status by forms of resistance traceable to scholars' anxiety. Examples of such exiety are the 'fear of faith' and the 'fear of the literal.'...

  5. Grand Canonical Ensemble Monte Carlo Simulation of Depletion Interactions in Colloidal Suspensions

    Institute of Scientific and Technical Information of China (English)

    GUO Ji-Yuan; XIAO Chang-Ming

    2008-01-01

    Depletion interactions in colloidal suspensions confined between two parallel plates are investigated by using acceptance ratio method with grand canonical ensemble Monte Carlo simulation.The numerical results show that both the depletion potential and depletion force are affected by the confinement from the two parallel plates.Furthermore,it is found that in the grand canonical ensemble Monte Carlo simulation,the depletion interactions are strongly affected by the generalized chemical potential.

  6. Development of Canonical Marine Aviation Logistics Support Program II (MALSP II) Deployment

    Science.gov (United States)

    2015-06-01

    logistics supply chain. A supply chain is a complex dynamic network involving the flow of information, material , and funds (Ahn, Lee, & Park, 2003, p...CANONICAL MARINE AVIATION LOGISTICS SUPPORT PROGRAM II (MALSP II) DEPLOYMENT by Brian M. Bagley June 2015 Thesis Advisor: Chad W. Seagren...3. REPORT TYPE AND DATES COVERED Master’s Thesis 4. TITLE AND SUBTITLE DEVELOPMENT OF CANONICAL MARINE AVIATION LOGISTICS SUPPORT PROGRAM II

  7. Canonical simulations of supersymmetric SU(N) Yang-Mills quantum mechanics

    CERN Document Server

    Bergner, Georg; Wenger, Urs

    2015-01-01

    The fermion loop formulation naturally separates partition functions into their canonical sectors. Here we discuss various strategies to make use of this for supersymmetric SU(N) Yang-Mills quantum mechanics obtained from dimensional reduction in various dimensions and present numerical results for the separate canonical sectors with fixed fermion numbers. We comment on potential problems due to the sign of the contributions from the fermions and due to flat directions.

  8. Deoxycholic acid mediates non-canonical EGFR-MAPK activation through the induction of calcium signaling in colon cancer cells.

    Science.gov (United States)

    Centuori, Sara M; Gomes, Cecil J; Trujillo, Jesse; Borg, Jamie; Brownlee, Joshua; Putnam, Charles W; Martinez, Jesse D

    2016-07-01

    Obesity and a western diet have been linked to high levels of bile acids and the development of colon cancer. Specifically, increased levels of the bile acid deoxycholic acid (DCA), an established tumor promoter, has been shown to correlate with increased development of colorectal adenomas and progression to carcinoma. Herein we investigate the mechanism by which DCA leads to EGFR-MAPK activation, a candidate mechanism by which DCA may promote colorectal tumorigenesis. DCA treated colon cancer cells exhibited strong and prolonged activation of ERK1/2 when compared to EGF treatment alone. We also showed that DCA treatment prevents EGFR degradation as opposed to the canonical EGFR recycling observed with EGF treatment. Moreover, the combination of DCA and EGF treatment displayed synergistic activity, suggesting DCA activates MAPK signaling in a non-canonical manner. Further evaluation showed that DCA treatment increased intracellular calcium levels and CAMKII phosphorylation, and that blocking calcium with BAPTA-AM abrogated MAPK activation induced by DCA, but not by EGF. Finally we showed that DCA-induced CAMKII leads to MAPK activation through the recruitment of c-Src. Taken together, we demonstrated that DCA regulates MAPK activation through calcium signaling, an alternative mechanism not previously recognized in human colon cancer cells. Importantly, this mechanism allows for EGFR to escape degradation and thus achieve a constitutively active state, which may explain its tumor promoting effects.

  9. Splitting K-symplectic methods for non-canonical separable Hamiltonian problems

    Science.gov (United States)

    Zhu, Beibei; Zhang, Ruili; Tang, Yifa; Tu, Xiongbiao; Zhao, Yue

    2016-10-01

    Non-canonical Hamiltonian systems have K-symplectic structures which are preserved by K-symplectic numerical integrators. There is no universal method to construct K-symplectic integrators for arbitrary non-canonical Hamiltonian systems. However, in many cases of interest, by using splitting, we can construct explicit K-symplectic methods for separable non-canonical systems. In this paper, we identify situations where splitting K-symplectic methods can be constructed. Comparative numerical experiments in three non-canonical Hamiltonian problems show that symmetric/non-symmetric splitting K-symplectic methods applied to the non-canonical systems are more efficient than the same-order Gauss' methods/non-symmetric symplectic methods applied to the corresponding canonicalized systems; for the non-canonical Lotka-Volterra model, the splitting algorithms behave better in efficiency and energy conservation than the K-symplectic method we construct via generating function technique. In our numerical experiments, the favorable energy conservation property of the splitting K-symplectic methods is apparent.

  10. Sparse canonical correlation analysis for identifying, connecting and completing gene-expression networks

    Directory of Open Access Journals (Sweden)

    Zwinderman Aeilko H

    2009-09-01

    Full Text Available Abstract Background We generalized penalized canonical correlation analysis for analyzing microarray gene-expression measurements for checking completeness of known metabolic pathways and identifying candidate genes for incorporation in the pathway. We used Wold's method for calculation of the canonical variates, and we applied ridge penalization to the regression of pathway genes on canonical variates of the non-pathway genes, and the elastic net to the regression of non-pathway genes on the canonical variates of the pathway genes. Results We performed a small simulation to illustrate the model's capability to identify new candidate genes to incorporate in the pathway: in our simulations it appeared that a gene was correctly identified if the correlation with the pathway genes was 0.3 or more. We applied the methods to a gene-expression microarray data set of 12, 209 genes measured in 45 patients with glioblastoma, and we considered genes to incorporate in the glioma-pathway: we identified more than 25 genes that correlated > 0.9 with canonical variates of the pathway genes. Conclusion We concluded that penalized canonical correlation analysis is a powerful tool to identify candidate genes in pathway analysis.

  11. Non-canonical distribution and non-equilibrium transport beyond weak system-bath coupling regime: A polaron transformation approach

    Science.gov (United States)

    Xu, Dazhi; Cao, Jianshu

    2016-08-01

    The concept of polaron, emerged from condense matter physics, describes the dynamical interaction of moving particle with its surrounding bosonic modes. This concept has been developed into a useful method to treat open quantum systems with a complete range of system-bath coupling strength. Especially, the polaron transformation approach shows its validity in the intermediate coupling regime, in which the Redfield equation or Fermi's golden rule will fail. In the polaron frame, the equilibrium distribution carried out by perturbative expansion presents a deviation from the canonical distribution, which is beyond the usual weak coupling assumption in thermodynamics. A polaron transformed Redfield equation (PTRE) not only reproduces the dissipative quantum dynamics but also provides an accurate and efficient way to calculate the non-equilibrium steady states. Applications of the PTRE approach to problems such as exciton diffusion, heat transport and light-harvesting energy transfer are presented.

  12. A review of the evidence for the canonical Wnt pathway in autism spectrum disorders

    Directory of Open Access Journals (Sweden)

    Kalkman Hans

    2012-10-01

    Full Text Available Abstract Microdeletion and microduplication copy number variations are found in patients with autism spectrum disorder and in a number of cases they include genes that are involved in the canonical Wnt signaling pathway (for example, FZD9, BCL9 or CDH8. Association studies investigating WNT2, DISC1, MET, DOCK4 or AHI1 also provide evidence that the canonical Wnt pathway might be affected in autism. Prenatal medication with sodium-valproate or antidepressant drugs increases autism risk. In animal studies, it has been found that these medications promote Wnt signaling, including among others an increase in Wnt2 gene expression. Notably, the available genetic information indicates that not only canonical Wnt pathway activation, but also inhibition seems to increase autism risk. The canonical Wnt pathway plays a role in dendrite growth and suboptimal activity negatively affects the dendritic arbor. In principle, this provides a logical explanation as to why both hypo- and hyperactivity may generate a similar set of behavioral and cognitive symptoms. However, without a validated biomarker to stratify for deviant canonical Wnt pathway activity, it is probably too dangerous to treat patients with compounds that modify pathway activity.

  13. Natural chymotrypsin-like-cleaved human mitochondrial peptides confirm tetra-, pentacodon, non-canonical RNA translations.

    Science.gov (United States)

    Seligmann, Hervé

    2016-09-01

    Mass spectra of human mitochondrial peptides match non-canonical transcripts systematically (a) deleting mono/dinucleotides after trinucleotides (delRNA), (b) exchanging nucleotides (swinger RNA), translated according to tri, (c) tetra- and pentacodons (codons expanded by a 4th (and 5th) silent nucleotide(s)). Swinger transcriptions are 23 bijective transformations, nine symmetric (XY, e.g. AC) and fourteen asymmetric exchanges (X->Y->Z->X, e.g. A->C->G->A). Here, proteomic analyses assuming cleavage after W,Y, F (chymotrypsin-like, for trypsinized samples) detect fewer chymotrypsinized than trypsinized peptides. Detected non-canonical peptides map preferentially on detected non-canonical RNAs for chymotrypsinized peptides, as previously found for trypsinized peptides. This suggests residual natural chymotrypsin-like digestion detectable within experimentally trypsinized peptide data. Some trypsinized peptides are detected twice, by analyses assuming trypsin, and those assuming chymotrypsin cleavages. They have higher spectra counts than peptides detected only once, meaning that abundant peptides are more frequently detected, but detection certainties resemble those for peptides detected only once. Analyses assuming 'incorrect' digestions are inadequate negative controls for digestion enzymes naturally active in biological samples. Chymotrypsin-analyses confirm non-canonical transcriptions/translations independently of results obtained assuming trypsinization, increase non-canonical peptidome coverage, indicating mitogenome-encoding of yet undetected proteins.

  14. Repeatability Using Automatic Tracing with Canon OCT- HS100 and Zeiss Cirrus HD-OCT 5000.

    Directory of Open Access Journals (Sweden)

    Rune Brautaset

    Full Text Available Optical coherence tomography (OCT, can be used in clinical practice to provide high resolution cross-sectional images of the retina, optic disc and macula structure. These measurements can be useful for early detection, diagnosis, monitoring and treatment guidance for retinal diseases. Therefore, repeatability of measurements in OCT is of great importance.Macula and optic disc parameters from the right eye of 30 healthy subjects were obtained twice with the Canon OCT-HS100 and Zeiss Cirrus HD-OCT 5000. Repeatability was evaluated by use of the coefficient of repeatability (CR and the coefficient of repeatability as a percentage of the mean (CR%, and the obtained measurements were compared between the instruments.CR% of optic disc parameters ranged between 0.90 and 22.22% and 0.00 and 16.00% with the Canon and Zeiss OCT respectively. For macular parameters CR% ranged between 0.62 and 2.81% and 0.99 and 1.81% with the Canon and Zeiss OCT respectively. No statistical difference could be found when comparing the CR of all macular and disc measurements between the instruments. Compared to our previously published data repeatability has significantly improved with the inclusion of automatic tracking systems with both the Canon and Zeiss OCT.Automatic tracking function improves repeatability in both Canon OCT-HS100 and Zeiss Cirrus HD-OCT 5000. However, measurements generated by the two instruments are still not interchangeable.

  15. Spatio-chromatic adaptation via higher-order canonical correlation analysis of natural images.

    Directory of Open Access Journals (Sweden)

    Michael U Gutmann

    Full Text Available Independent component and canonical correlation analysis are two general-purpose statistical methods with wide applicability. In neuroscience, independent component analysis of chromatic natural images explains the spatio-chromatic structure of primary cortical receptive fields in terms of properties of the visual environment. Canonical correlation analysis explains similarly chromatic adaptation to different illuminations. But, as we show in this paper, neither of the two methods generalizes well to explain both spatio-chromatic processing and adaptation at the same time. We propose a statistical method which combines the desirable properties of independent component and canonical correlation analysis: It finds independent components in each data set which, across the two data sets, are related to each other via linear or higher-order correlations. The new method is as widely applicable as canonical correlation analysis, and also to more than two data sets. We call it higher-order canonical correlation analysis. When applied to chromatic natural images, we found that it provides a single (unified statistical framework which accounts for both spatio-chromatic processing and adaptation. Filters with spatio-chromatic tuning properties as in the primary visual cortex emerged and corresponding-colors psychophysics was reproduced reasonably well. We used the new method to make a theory-driven testable prediction on how the neural response to colored patterns should change when the illumination changes. We predict shifts in the responses which are comparable to the shifts reported for chromatic contrast habituation.

  16. Rapid ecotoxicological assessment of heavy metal combined polluted soil using canonical analysis

    Institute of Scientific and Technical Information of China (English)

    CHEN Su-hua; ZHOU Qi-xing; SUN Tie-heng; LI Pei-jun

    2003-01-01

    Quick, simple to perform, and cheap biomarkers were combined in a rapid assessment approach to measure the effects of metal pollutants, Cu, Cd, Pb and Zn in meadow burozem on wheat. Analysis of orthogonal design showed that the significant zinc factor indicated both the inhibition rate of shoot mass and that of root elongation were affected by zinc( P < 0.05 and P < 0.01, respectively). The first toxicity canonical variable (TOXI), formed from the toxicity data set, explained 49% of the total variance in the toxicity data set; the first biological canonical variable(BIOL) explained 42% of the total variation in the biological data set. The correlation between the first canonical variables TOXI and BIOL (canonical correlation) was 0.94 ( P < 0.0001). Therefore, it is reliable and feasible to use the achievement to assess toxicity of heavy metal combined polluted soil using canonical analysis. Toxicity of soil combined polluted by heavy metals to plant community was estimated by comparing the IC50 values describing the concentration needed to cause 50% decrease with grow rate compared to no metal addition. Environmental quality standard for soils prescribe that all these tested concentration of heavy metals in soil should not cause hazard and pollution ultimately, whereas it indicated that the soils in second grade cause more or less than 50% inhibition rates of wheat growth. So environmental quality standard for soils can be modified to include other features.

  17. Low hardness EPDM/PP thermoplastic dynamic vulcanizates Ⅱ. Effect on micromorphology of preparation technological conditions%低硬度EPDM/PP热塑性动态硫化胶Ⅱ.制备工艺条件对微观相态结构的影响

    Institute of Scientific and Technical Information of China (English)

    吴崇刚; 朱玉俊; 孙亚娟; 冯予星; 张飞; 郭杰

    2001-01-01

    通过正交试验设计,研究了低硬度EPDM/PP共混型热塑性动态硫化胶的反应挤出动态硫化制备工艺,初步探讨了机筒温度、喂料螺杆驱动电压及主机螺杆转速等主要工艺因素对挤出物徽观相态结构的影响。%Through orthogonal experiment design,the preparation technology of reactive extrusion dy-namic vulcanization for low hardness EPDM/PPblend thermoplastic dynamic vulcanizates was stud-ied,and the effects on micromorphology of extrudedvulcanizates of such main technological factors asbarrel temperature,feed screw driven voltage andhost machine screw rotation rate were discussed.

  18. Graded algebraic structure in the canonical formulation of N = 3 chiral supergravity

    CERN Document Server

    Tsuda, M

    2004-01-01

    We focus on N = 3 chiral supergravity (SUGRA) which is the lowest N theory involving a spin-1/2 field, and derive the Ashtekar's canonical formulation of N = 3 SUGRA starting with the chiral Lagrangian constructed by closely following the standard SUGRA. The polynomiality of constraints in terms of canonical variables and the graded algebraic structure of constraints are discussed in the canonical formulation. In particular, we show the polynomiality of the {\\it rescaled} right- and left-handed SUSY constraints by a nonpolynomial factor. And also we show the graded algebraic structure of Osp(3/2) in the constraint algebra by calculating the Poisson brackets of Gauss, SU(2) gauge and right-handed SUSY constraints, although the algebra among only those three types of constraints does not closed.

  19. Transforming differential equations of multi-loop Feynman integrals into canonical form

    CERN Document Server

    Meyer, Christoph

    2016-01-01

    The method of differential equations has been proven to be a powerful tool for the computation of multi-loop Feynman integrals appearing in quantum field theory. It has been observed that in many instances a canonical basis can be chosen, which drastically simplifies the solution of the differential equation. In this paper, an algorithm is presented that computes the transformation to a canonical basis, starting from some basis that is, for instance, obtained by the usual integration-by-parts reduction techniques. The algorithm requires the existence of a rational transformation to a canonical basis, but is otherwise completely agnostic about the differential equation. In particular, it is applicable to problems involving multiple scales and allows for a rational dependence on the dimensional regulator. It is demonstrated that the algorithm is suitable for current multi-loop calculations by presenting its successful application to a number of non-trivial examples.

  20. Canonical Wnt signalling regulates epithelial patterning by modulating levels of laminins in zebrafish appendages.

    Science.gov (United States)

    Nagendran, Monica; Arora, Prateek; Gori, Payal; Mulay, Aditya; Ray, Shinjini; Jacob, Tressa; Sonawane, Mahendra

    2015-01-15

    The patterning and morphogenesis of body appendages - such as limbs and fins - is orchestrated by the activities of several developmental pathways. Wnt signalling is essential for the induction of limbs. However, it is unclear whether a canonical Wnt signalling gradient exists and regulates the patterning of epithelium in vertebrate appendages. Using an evolutionarily old appendage - the median fin in zebrafish - as a model, we show that the fin epithelium exhibits graded changes in cellular morphology along the proximo-distal axis. This epithelial pattern is strictly correlated with the gradient of canonical Wnt signalling activity. By combining genetic analyses with cellular imaging, we show that canonical Wnt signalling regulates epithelial cell morphology by modulating the levels of laminins, which are extracellular matrix components. We have unravelled a hitherto unknown mechanism involved in epithelial patterning, which is also conserved in the pectoral fins - evolutionarily recent appendages that are homologous to tetrapod limbs.

  1. Classifications and canonical forms of tensor product expressions in the presence of permutation symmetries

    CERN Document Server

    Li, Zhendong; Liu, Wenjian

    2016-01-01

    Complicated mathematical equations involving tensors with permutation symmetries are frequently encountered in fields such as quantum chemistry, e.g., those in coupled cluster theories and derivatives of wavefunction parameters. In automatic derivations of these equations, a key step is the collection of product terms that can be found identical by using permutation symmetries or relabelling dummy indices. In the present work, we define a canonical form for a general tensor product in the presence of permutation symmetries as a result of the classification of all tensor products from a group theoretical point of view. To make such definition of practical use, we provide an efficient algorithm to compute the canonical form by combining the classical backtrack search for permutation groups and the idea of partitions used in graph isomorphism algorithms. The resulted algorithm can compute canonical forms and generators of the automorphism groups of tensor expressions. Moreover, for tensor products with external ...

  2. The Canonical Correlation Analysis on Semen Quality and Serum Heavy Metals in Chinese Young Men

    Institute of Scientific and Technical Information of China (English)

    Jun-qing WU; Jiang ZHU; Zhan-hai FU; Yin-mei DU; Cui-ling LIANG; Er-sheng GAO; Jian-guo TAO; Qiu-ying YANG; Xiao XU; Wen-juan CAI; Jian GUO; Feng TANG

    2003-01-01

    Objective To explore the correlation between serum heavy metal and semen quality in normal Chinese young menMethods This study was designed as a multi-center cross-sectional investigation. The subjects consisted of 562 male vomunteers who had undergone premarital physical examination in maternal and children health centers in 7 provinces in China.Results Results from Spearman rank correlation analysis (partial variable: region) show that serum lead and cadmium are negatively related to percentage of morphological normal sperm, but canonical correlation between semen quality and serum heavy metal are not significant. Canonical correlation analysis among the subjects from Guizhou shows cadmium is harmful to sperm morphology. In Henan, furthermore, results show lead and cadmium could negatively affect sperm viability and morphology.Conclusion Among all study subjects, canonical correlation between semen quality and serum heavy metal were not significant; however, results in some region showed serum cadmium and lead might be harmful to sperm quality.

  3. Domain walls, $Z(N)$ charge and $A_0$ condensate a canonical ensemble study

    CERN Document Server

    Borisenko, O A; Zinovjev, G M; Petrov, K V

    1996-01-01

    The deconfinement phase transition is studied in the ensemble canonical with respect to triality. Since this ensemble implies a projection to the zero triality sector of the theory we introduce a quantity which is insensitive to $Z(N_c)$ symmetry but can reveal a critical behaviour in the theory with dynamical quarks. Further, we argue that in the canonical ensemble description of full QCD there exist domains of different $Z(N_c)$ phases which are degenerate and possess normal physical properties. This contradicts the predictions of the grand canonical ensemble. We propose a new order parameter to test the realization of the discrete $Z(N_c)$ symmetry at finite temperature and calculate it for the case of $Z(2)$ gauge fields coupled to fundamental fermions.

  4. Generalized second law of thermodynamics for non-canonical scalar field model with corrected-entropy

    Science.gov (United States)

    Das, Sudipta; Debnath, Ujjal; Mamon, Abdulla Al

    2015-10-01

    In this work, we have considered a non-canonical scalar field dark energy model in the framework of flat FRW background. It has also been assumed that the dark matter sector interacts with the non-canonical dark energy sector through some interaction term. Using the solutions for this interacting non-canonical scalar field dark energy model, we have investigated the validity of generalized second law (GSL) of thermodynamics in various scenarios using first law and area law of thermodynamics. For this purpose, we have assumed two types of horizons viz apparent horizon and event horizon for the universe and using first law of thermodynamics, we have examined the validity of GSL on both apparent and event horizons. Next, we have considered two types of entropy-corrections on apparent and event horizons. Using the modified area law, we have examined the validity of GSL of thermodynamics on apparent and event horizons under some restrictions of model parameters.

  5. Generalized Second Law of Thermodynamics for Non-canonical Scalar Field Model with Corrected-Entropy

    CERN Document Server

    Das, Sudipta; Mamon, Abdulla Al

    2015-01-01

    In this work, we have considered a non-canonical scalar field dark energy model in the framework of flat FRW background. It has also been assumed that the dark matter sector interacts with the non-canonical dark energy sector through some interaction term. Using the solutions for this interacting non-canonical scalar field dark energy model, we have investigated the validity of generalized second law (GSL) of thermodynamics in various scenarios using first law and area law of thermodynamics. For this purpose, we have assumed two types of horizons viz apparent horizon and event horizon for the universe and using first law of thermodynamics, we have examined the validity of GSL on both apparent and event horizons. Next, we have considered two types of entropy-corrections on apparent and event horizons. Using the modified area law, we have examined the validity of GSL of thermodynamics on apparent and event horizons under some restrictions of model parameters.

  6. Generalized second law of thermodynamics for non-canonical scalar field model with corrected-entropy

    Energy Technology Data Exchange (ETDEWEB)

    Das, Sudipta; Mamon, Abdulla Al [Visva-Bharati, Department of Physics, Santiniketan (India); Debnath, Ujjal [Indian Institute of Engineering Science and Technology, Department of Mathematics, Shibpur, Howrah (India)

    2015-10-15

    In this work, we have considered a non-canonical scalar field dark energy model in the framework of flat FRW background. It has also been assumed that the dark matter sector interacts with the non-canonical dark energy sector through some interaction term. Using the solutions for this interacting non-canonical scalar field dark energy model, we have investigated the validity of generalized second law (GSL) of thermodynamics in various scenarios using first law and area law of thermodynamics. For this purpose, we have assumed two types of horizons viz apparent horizon and event horizon for the universe and using first law of thermodynamics, we have examined the validity of GSL on both apparent and event horizons. Next, we have considered two types of entropy-corrections on apparent and event horizons. Using the modified area law, we have examined the validity of GSL of thermodynamics on apparent and event horizons under some restrictions of model parameters. (orig.)

  7. Distribution and genetic diversity of functional microorganisms in different CANON reactors.

    Science.gov (United States)

    Liu, Tao; Li, Dong; Zeng, Huiping; Li, Xiangkun; Liang, Yuhai; Chang, Xiaoyan; Zhang, Jie

    2012-11-01

    Completely autotrophic nitrogen removal over nitrite (CANON) has been regarded as an efficient and economical process for nitrogen removal from wastewater. The distribution and genetic diversity of the functional microorganisms in five lab-scale CANON reactors have been investigated by using some molecular biology methods. Nitrosomonas-like aerobic ammonium oxidizing bacteria (AerAOB) and Candidatus Brocadia-related anaerobic ammonium oxidizing bacteria (AnAOB) were detected as predominant functional microbes in the five reactors while Nitrobacter-like nitrite oxidizing bacteria (NOB) existed only in the systems operated at ambient temperature. Communities of AerAOB and AnAOB were almost similar among the five reactors while the distribution of the functional microbes was either scattered or densely packed. Meanwhile, this study has demonstrated the feasibility of starting up CANON by inoculating conventional activated sludge in low ammonium content at ambient temperature.

  8. Compositional and functional diversity of canonical PRC1 complexes in mammals.

    Science.gov (United States)

    Connelly, Katelyn E; Dykhuizen, Emily C

    2017-02-01

    The compositional complexity of Polycomb Repressive Complex 1 (PRC1) increased dramatically during vertebrate evolution. What is considered the "canonical" PRC1 complex consists of four subunits originally identified as regulators of body segmentation in Drosophila. In mammals, each of these four canonical subunits consists of two to six paralogs that associate in a combinatorial manner to produce over a hundred possible distinct PRC1 complexes with unknown function. Genetic studies have begun to define the phenotypic roles for different PRC1 paralogs; however, relating these phenotypes to unique biochemical and transcriptional function for the different paralogs has been challenging. In this review, we attempt to address how the compositional diversity of canonical PRC1 complexes relates to unique roles for individual PRC1 paralogs in transcriptional regulation. This review focuses primarily on PRC1 complex composition, genome targeting, and biochemical function.

  9. A switch from canonical to noncanonical autophagy shapes B cell responses.

    Science.gov (United States)

    Martinez-Martin, Nuria; Maldonado, Paula; Gasparrini, Francesca; Frederico, Bruno; Aggarwal, Shweta; Gaya, Mauro; Tsui, Carlson; Burbage, Marianne; Keppler, Selina Jessica; Montaner, Beatriz; Jefferies, Harold B J; Nair, Usha; Zhao, Yan G; Domart, Marie-Charlotte; Collinson, Lucy; Bruckbauer, Andreas; Tooze, Sharon A; Batista, Facundo D

    2017-02-10

    Autophagy is important in a variety of cellular and pathophysiological situations; however, its role in immune responses remains elusive. Here, we show that among B cells, germinal center (GC) cells exhibited the highest rate of autophagy during viral infection. In contrast to mechanistic target of rapamycin complex 1-dependent canonical autophagy, GC B cell autophagy occurred predominantly through a noncanonical pathway. B cell stimulation was sufficient to down-regulate canonical autophagy transiently while triggering noncanonical autophagy. Genetic ablation of WD repeat domain, phosphoinositide-interacting protein 2 in B cells alone enhanced this noncanonical autophagy, resulting in changes of mitochondrial homeostasis and alterations in GC and antibody-secreting cells. Thus, B cell activation prompts a temporal switch from canonical to noncanonical autophagy that is important in controlling B cell differentiation and fate.

  10. Non-Canonical Hh Signaling in Cancer—Current Understanding and Future Directions

    Directory of Open Access Journals (Sweden)

    Dongsheng Gu

    2015-08-01

    Full Text Available As a major regulatory pathway for embryonic development and tissue patterning, hedgehog signaling is not active in most adult tissues, but is reactivated in a number of human cancer types. A major milestone in hedgehog signaling in cancer is the Food and Drug Administration (FDA approval of a smoothened inhibitor Vismodegib for treatment of basal cell carcinomas. Vismodegib can block ligand-mediated hedgehog signaling, but numerous additional clinical trials have failed to show significant improvements in cancer patients. Amounting evidence indicate that ligand-independent hedgehog signaling plays an essential role in cancer. Ligand-independent hedgehog signaling, also named non-canonical hedgehog signaling, generally is not sensitive to smoothened inhibitors. What we know about non-canonical hedgehog signaling in cancer, and how should we prevent its activation? In this review, we will summarize recent development of non-canonical hedgehog signaling in cancer, and will discuss potential ways to prevent this type of hedgehog signaling.

  11. Primary cilia are not required for normal canonical Wnt signaling in the mouse embryo.

    Directory of Open Access Journals (Sweden)

    Polloneal Jymmiel R Ocbina

    Full Text Available Sonic hedgehog (Shh signaling in the mouse requires the microtubule-based organelle, the primary cilium. The primary cilium is assembled and maintained through the process of intraflagellar transport (IFT and the response to Shh is blocked in mouse mutants that lack proteins required for IFT. Although the phenotypes of mouse IFT mutants do not overlap with phenotypes of known Wnt pathway mutants, recent studies report data suggesting that the primary cilium modulates responses to Wnt signals.We therefore carried out a systematic analysis of canonical Wnt signaling in mutant embryos and cells that lack primary cilia because of loss of the anterograde IFT kinesin-II motor (Kif3a or IFT complex B proteins (Ift172 or Ift88. We also analyzed mutant embryos with abnormal primary cilia due to defects in retrograde IFT (Dync2h1. The mouse IFT mutants express the canonical Wnt target Axin2 and activate a transgenic canonical Wnt reporter, BAT-gal, in the normal spatial pattern and to the same quantitative level as wild type littermates. Similarly, mouse embryonic fibroblasts (MEFs derived from IFT mutants respond normally to added Wnt3a. The switch from canonical to non-canonical Wnt also appears normal in IFT mutant MEFs, as both wild-type and mutant cells do not activate the canonical Wnt reporter in the presence of both Wnt3a and Wnt5a.We conclude that loss of primary cilia or defects in retrograde IFT do not affect the response of the midgestation embryo or embryo-derived fibroblasts to Wnt ligands.

  12. Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells.

    Directory of Open Access Journals (Sweden)

    Laura Corbett

    Full Text Available The Wnt system is highly complex and is comprised of canonical and non-canonical pathways leading to the activation of gene expression. Our aim was to examine changes in the expression of Wnt ligands and regulators during hepatic stellate cell (HSC transdifferentiation and assess the relative contributions of the canonical and non-canonical Wnt pathways in fibrogenic activated HSC. The expression profile of Wnt ligands and regulators in HSC was not supportive for a major role for β-catenin-dependent canonical Wnt signalling, this verified by inability to induce Topflash reporter activity in HSC even when expressing a constitutive active β-catenin. We detected expression of Wnt5a in activated HSC which can signal via non-canonical mechanisms and showed evidence for non-canonical signalling in these cells involving phosphorylation of Dvl2 and pJNK. Stimulation of HSC or Kupffer cells with Wnt5a regulated HSC apoptosis and expression of TGF-β1 and MCP1 respectively. We were unable to confirm a role for β-catenin-dependent canonical Wnt in HSC and instead propose autocrine and paracrine functions for Wnts expressed by activated HSC via non-canonical pathways. The data warrant detailed investigation of Wnt5a in liver fibrosis.

  13. Generalized BF state in quantum gravity

    CERN Document Server

    Yamashita, Shinji; Fukuda, Makoto

    2014-01-01

    The BF state is known as a simple wave function which satisfies three constraints in canonical quantum gravity without a cosmological constant. It is constructed from a product of the group delta functions. Applying the chiral asymmetric extension, the BF state is generalized to the state for the real values of the Barbero-Immirzi parameter.

  14. Do cysteine residues regulate transient receptor potential canonical type 6 (TRPC6) channel protein expression?

    DEFF Research Database (Denmark)

    Thilo, Florian; Liu, Ying; Krueger, Katharina;

    2012-01-01

    The regulation of calcium influx through transient receptor potential canonical type 6 channel is mandatory for the activity of human monocytes. We submit the first evidence that cysteine residues of homocysteine or acetylcysteine affect TRPC6 expression in human monocytes. We observed that patie......The regulation of calcium influx through transient receptor potential canonical type 6 channel is mandatory for the activity of human monocytes. We submit the first evidence that cysteine residues of homocysteine or acetylcysteine affect TRPC6 expression in human monocytes. We observed...... to control conditions. We therefore hypothesize that cysteine residues increase TRPC6 channel protein expression in humans....

  15. Discrete canonical analysis of three-dimensional gravity with cosmological constant

    Science.gov (United States)

    Berra-Montiel, J.; E. Rosales-Quintero, J.

    2015-05-01

    We discuss the interplay between standard canonical analysis and canonical discretization in three-dimensional gravity with cosmological constant. By using the Hamiltonian analysis, we find that the continuum local symmetries of the theory are given by the on-shell space-time diffeomorphisms, which at the action level, correspond to the Kalb-Ramond transformations. At the time of discretization, although this symmetry is explicitly broken, we prove that the theory still preserves certain gauge freedom generated by a constant curvature relation in terms of holonomies and the Gauss's law in the lattice approach.

  16. An algorithm for calculation of the Jordan canonical form of a matrix

    Science.gov (United States)

    Sridhar, B.; Jordan, D.

    1973-01-01

    Jordan canonical forms are used extensively in the literature on control systems. However, very few methods are available to compute them numerically. Most numerical methods compute a set of basis vectors in terms of which the given matrix is diagonalized when such a change of basis is possible. Here, a simple and efficient method is suggested for computing the Jordan canonical form and the corresponding transformation matrix. The method is based on the definition of a generalized eigenvector, and a natural extension of Gauss elimination techniques.

  17. BRST quantization and canonical Ward identity of the supersymmetric electromagnetic interaction system

    Institute of Scientific and Technical Information of China (English)

    HUANG YongChang; JIANG YunGuo; LI XinGuo

    2007-01-01

    According to the method of path integral quantization for the canonical constrained system in Becchi-Rouet-Stora-Tyutin scheme, the supersymmetric electromagnetic interaction system was quantized. Both the Hamiltonian of the supersymmetric electromagnetic interaction system in phase space and the quantization procedure were simplified. The BRST generator was constructed, and the BRST transformations of supersymmetric fields were gotten; the effective action was calculated, and the generating functional for the Green function was achieved; also, the gauge generator was constructed, and the gauge transformation of the system was obtained. Finally, the Ward-Takahashi identities based on the canonical Noether theorem were calculated, and two relations between proper vertices and propagators were obtained.

  18. Gauge-covariant canonical formalism revisited with application to the proton spin decomposition

    CERN Document Server

    Lorcé, Cédric

    2013-01-01

    We revisit the gauge-covariant canonical formalism by separating explicitly physical and gauge degrees of freedom. We show in particular that the gauge-invariant linear and angular momentum operators proposed by Chen et al. can consistently be derived from the standard procedure based on the Noether's theorem. Finally, we demonstrate that this approach is essentially equivalent to the gauge-invariant canonical formalism based on the concept of Dirac variables. Because of many similarities with the background field method, the formalism developed here should also be relevant to general relativity and any metric theories.

  19. The difference between the Weil height and the canonical height on elliptic curves

    Science.gov (United States)

    Silverman, Joseph H.

    1990-10-01

    Estimates for the difference of the Weil height and the canonical height of points on elliptic curves are used for many purposes, both theoretical and computational. In this note we give an explicit estimate for this difference in terms of the j-invariant and discriminant of the elliptic curve. The method of proof, suggested by Serge Lang, is to use the decomposition of the canonical height into a sum of local heights. We illustrate one use for our estimate by computing generators for the Mordell-Weil group in three examples.

  20. Full canonical information from grand-potential density-functional theory.

    Science.gov (United States)

    de Las Heras, Daniel; Schmidt, Matthias

    2014-12-05

    We present a general and formally exact method to obtain the canonical one-body density distribution and the canonical free energy from direct decomposition of classical density functional results in the grand ensemble. We test the method for confined one-dimensional hard-core particles for which the exact grand potential density functional is explicitly known. The results agree to within high accuracy with those from exact methods and our Monte Carlo many-body simulations. The method is relevant for treating finite systems and for dynamical density functional theory.

  1. ‘Dancing through the Minefield’: Canon Reinstatement Strategies for Women Authors

    Directory of Open Access Journals (Sweden)

    Dascăl Reghina

    2015-12-01

    Full Text Available The paper explores the limiting and detrimental effects of biographical criticism and exceptionalism in the efforts of reinstating women authors into the Renaissance canon, by looking into the literary merits of Elizabeth Cary’s The Tragedy of Mariam, The Fair Queen of Jewry and The History of The Life, Reign and Death of Edward II. Whereas the conflation of biography and fiction is a successful recipe for canonization and for the production of feminist icons, it renders the text impotent because of its resulting inability to compete with or to be seen in correlation and interplay with other contemporary texts.

  2. A canonical formalism of f(R)-type gravity in terms of Lie derivatives

    Energy Technology Data Exchange (ETDEWEB)

    Ezawa, Y [Department of Physics, Ehime University, Matsuyama 790-8577 (Japan); Iwasaki, H [Department of Physics, Ehime University, Matsuyama 790-8577 (Japan); Ohkuwa, Y [Section of Mathematical Science, Department of Social Medicine, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889-1692 (Japan); Watanabe, S [Department of Physics, Ehime University, Matsuyama 790-8577 (Japan); Yamada, N [Department of Physics, Ehime University, Matsuyama 790-8577 (Japan); Yano, T [Department of Electrical Engineering, Ehime University, Matsuyama 790-8577 (Japan)

    2006-05-07

    We propose a canonical formalism of f(R)-type gravity using a set of phase variables which is partly different from that used in the formalism of Buchbinder and Lyakhovich (BL). The new coordinates corresponding to the time derivatives of the metric are taken to be the Lie derivatives of the metric, which is the same as in BL. The momenta canonically conjugate to the new coordinates and Hamiltonian density are defined similarly to the formalism of Ostrogradski. It is shown that, in our formalism, the Hamiltonian is invariant under the change of the original coordinates, which is not the case in the formalism of BL.

  3. Power Spectra beyond the Slow Roll Approximation in Theories with Non-Canonical Kinetic Terms

    CERN Document Server

    van de Bruck, Carsten

    2014-01-01

    We derive analytical expressions for the power spectra at the end of inflation in theories with two inflaton fields and non-canonical kinetic terms. We find that going beyond the slow-roll approximation is necessary and that the nature of the non-canonical terms have an important impact on the final power spectra at the end of inflation. We study five models numerically and find excellent agreement with our analytical results. Our results emphasise the fact that going beyond the slow-roll approximation is important in times of high-precision data coming from cosmological observations.

  4. Renormalization procedure for random tensor networks and the canonical tensor model

    CERN Document Server

    Sasakura, Naoki

    2015-01-01

    We discuss a renormalization procedure for random tensor networks, and show that the corresponding renormalization-group flow is given by the Hamiltonian vector flow of the canonical tensor model, which is a discretized model of quantum gravity. The result is the generalization of the previous one concerning the relation between the Ising model on random networks and the canonical tensor model with N=2. We also prove a general theorem which relates discontinuity of the renormalization-group flow and the phase transitions of random tensor networks.

  5. A Critique of Grossman's Canonical Model of Health Capital.

    Science.gov (United States)

    Sepehri, Ardeshir

    2015-01-01

    In the health economics literature, the demand for health and market health inputs is dominated by adaptations of Grossman's health capital model. The model has been widely used to explore a wide range of issues related to health, socioeconomic inequalities in health, demand for medical care, health preventions, occupational choice, and retirement decisions. The commodity of health is viewed as a durable capital stock that yields a flow of healthy time or illness-free time, that depreciates with age, and that can be augmented with the help of market health inputs and own time. The purpose of this article is to provide a comprehensive critical review of the model. Underlying Grossman's model are a faulty conceptual framework and assumptions that tend to exaggerate the degree of control consumers/patients may have over their state of health and survival. The assumption of full information about one's state of health and the efficacy of various health inputs abstracts away from the problems posed by the agency relationship under uncertainty and informational asymmetry. Grossman's individualistic and mechanistic view of health strips health capital and its production of much of their biological/physiological content and their interactions with the individual's social and physical environment.

  6. Canonical FGFs Prevent Osteogenic Lineage Commitment and Differentiation of Human Bone Marrow Stromal Cells Via ERK1/2 Signaling.

    Science.gov (United States)

    Simann, Meike; Le Blanc, Solange; Schneider, Verena; Zehe, Viola; Lüdemann, Martin; Schütze, Norbert; Jakob, Franz; Schilling, Tatjana

    2017-02-01

    Controlling the adipo-osteogenic lineage decision of trabecular human bone marrow stromal cells (hBMSCs) in favor of osteogenesis represents a promising approach for osteoporosis therapy and prevention. Previously, Fibroblast Growth Factor 1 (FGF1) and its subfamily member FGF2 were scored as leading candidates to exercise control over skeletal precursor commitment and lineage decision albeit literature results are highly inconsistent. We show here that FGF1 and 2 strongly prevent the osteogenic commitment and differentiation of hBMSCs. Mineralization of extracellular matrix (ECM) and mRNA expression of osteogenic marker genes Alkaline Phosphatase (ALP), Collagen 1A1 (COL1A1), and Integrin-Binding Sialoprotein (IBSP) were significantly reduced. Furthermore, master regulators of osteogenic commitment like Runt-Related Transcription Factor 2 (RUNX2) and Bone Morphogenetic Protein 4 (BMP4) were downregulated. When administered under adipogenic culture conditions, canonical FGFs did not support osteogenic marker expression. Moreover despite the presence of osteogenic differentiation factors, FGFs even disabled the pro-osteogenic lineage decision of pre-differentiated adipocytic cells. In contrast to FGF Receptor 2 (FGFR2), FGFR1 was stably expressed throughout osteogenic and adipogenic differentiation and FGF addition. Moreover, FGFR1 and Extracellular Signal-Regulated Kinases 1 and 2 (ERK1/2) were found to be responsible for underlying signal transduction using respective inhibitors. Taken together, we present new findings indicating that canonical FGFR-ERK1/2 signaling entrapped hBMSCs in a pre-committed state and arrested further maturation of committed precursors. Our results might aid in unraveling and controlling check points relevant for ageing-associated aberrant adipogenesis with consequences for the treatment of degenerative diseases such as osteoporosis and for skeletal tissue engineering strategies. J. Cell. Biochem. 118: 263-275, 2017. © 2016 Wiley

  7. The Ideology of Canons and Cultural Concerns in the Literature Curriculum. Report Series.

    Science.gov (United States)

    Purves, Alan C.

    Educators who are responsible for planning curricula in literature should wish to do so with a full respect for the diverse groups that comprise U.S. society. The current way of thinking about this problem in setting policy for literature instruction is in terms of the canon: that is, the traditional works and the order in which they are to be…

  8. From Classical to Quantum: New Canonical Tools for the Dynamics of Gravity

    NARCIS (Netherlands)

    Höhn, P.A.

    2012-01-01

    In a gravitational context, canonical methods offer an intuitive picture of the dynamics and simplify an identification of the degrees of freedom. Nevertheless, extracting dynamical information from background independent approaches to quantum gravity is a highly non-trivial challenge. In this thesi

  9. Canonical transformations and loop formulation of SU(N) lattice gauge theories

    Science.gov (United States)

    Mathur, Manu; Sreeraj, T. P.

    2015-12-01

    We construct canonical transformations to reformulate SU(N) Kogut-Susskind lattice gauge theory in terms of a set of fundamental loop and string flux operators along with their canonically conjugate loop and string electric fields. The canonical relations between the initial SU(N) link operators and the final SU(N) loop and string operators, consistent with SU(N) gauge transformations, are explicitly constructed over the entire lattice. We show that as a consequence of SU(N) Gauss laws all SU(N) string degrees of freedom become cyclic and decouple from the physical Hilbert space Hp. The Kogut-Susskind Hamiltonian rewritten in terms of the fundamental physical loop operators has global SU(N) invariance. There are no gauge fields. We further show that the (1 /g2 ) magnetic field terms on plaquettes create and annihilate the fundamental plaquette loop fluxes while the (g2 ) electric field terms describe all their interactions. In the weak coupling (g2→0 ) continuum limit the SU(N) loop dynamics is described by SU(N) spin Hamiltonian with nearest neighbor interactions. In the simplest SU(2) case, where the canonical transformations map the SU(2) loop Hilbert space into the Hilbert spaces of hydrogen atoms, we analyze the special role of the hydrogen atom dynamical symmetry group S O (4 ,2 ) in the loop dynamics and the spectrum. A simple tensor network ansatz in the SU(2) gauge invariant hydrogen atom loop basis is discussed.

  10. Interpreting canonical correlation analysis through biplots of stucture correlations and weights

    NARCIS (Netherlands)

    Braak, ter C.J.F.

    1990-01-01

    This paper extends the biplot technique to canonical correlation analysis and redundancy analysis. The plot of structure correlations is shown to the optimal for displaying the pairwise correlations between the variables of the one set and those of the second. The link between multivariate regressio

  11. Refined tropical curve counts and canonical bases for quantum cluster algebras

    DEFF Research Database (Denmark)

    Mandel, Travis

    We express the (quantizations of the) Gross-Hacking-Keel-Kontsevich canonical bases for cluster algebras in terms of certain (Block-Göttsche) weighted counts of tropical curves. In the process, we obtain via scattering diagram techniques a new invariance result for these Block-Göttsche counts....

  12. Donne's "The Token": A Lesson in the Fashion(ing) of Canon.

    Science.gov (United States)

    Baumlin, James S.

    1997-01-01

    Argues for the canonicity of "Sonnet: The Token," a John Donne poem whose authorship has been in doubt for some decades. Employs deconstruction as its critical approach, though that approach is nearly passe in Renaissance studies, and it calls the issue of authorship into question. (TB)

  13. Rational design of a non-canonical "sticky-ended" collagen triple helix.

    Science.gov (United States)

    Jalan, Abhishek A; Jochim, Katherine A; Hartgerink, Jeffrey D

    2014-05-28

    In a canonical collagen triple helix, three peptides self-assemble into a supercoiled motif with a one-amino-acid offset between the peptide chains. Design of triple helices that contain more than one residue offset is lucrative, as it leaves the non-covalent interactions unsatisfied at the termini and renders the termini "sticky" to further self-assemble into collagen-like nanofibers. Here we use lysine-glutamate axial salt-bridges to design a heterotrimeric collagen triple helix, ABC-1, containing a non-canonical offset of four residues between the peptide chains. The four-residue offset is necessary to prevent aggregation, which would prevent characterization of the non-canonical chain arrangement at the molecular level by NMR spectroscopy. A second heterotrimer, ABC-2, also stabilized by axial salt-bridges, is designed containing a canonical one-amino-acid offset to facilitate comparison of structure and stability by CD and NMR. ABC-1 and ABC-2 demonstrate our ability to modulate chain offset in a collagen triple helix. This lays the groundwork to design longer, and therefore stickier, offsets allowing access to a new class of collagen-related nanostructures.

  14. A canonical approach to electromagnetic field quantization in a nonhomogeneous and anisotropic magnetodielectric medium

    Energy Technology Data Exchange (ETDEWEB)

    Kheirandish, Fardin; Amooshahi, Majid; Soltani, Morteza [Department of Physics, University of Isfahan, Hezar Jarib Ave., Isfahan (Iran, Islamic Republic of)], E-mail: fardinkh@phys.ui.ac.ir, E-mail: amooshahi@phys.ui.ac.ir, E-mail: m.soltani@phys.ui.ac.ir

    2009-04-14

    In this paper, by extending the Lagrangian of the Huttner-Barnett model an electromagnetic field in a nonhomogeneous and anisotropic magnetodielectric medium is quantized canonically. In this model, Maxwell equations in the medium are obtained and solved using the Green function technique. The noise operators are found and the results are compared with the phenomenological method.

  15. New challenges of literary reading: canon and mediation in the readings of future teachers

    Directory of Open Access Journals (Sweden)

    José D. Dueñas

    2014-05-01

    Full Text Available Based on an analysis of more than sixty reports on own path reading students teachers of pre-school and primary education second during the courses 2011/12 and 2012/13, we have appreciated some relationships relevant between forms of mediation, canon reader and reading habits. Thus, we have observed some mediation styles that seem to lead with greater guarantees to reading success paths. We have classified our informants in three major groups, in accordance with Reader canon in which are installed: social canon readers and readers of academic canon, not readers. The better or worse quality mediation seems to be decisive in most of the cases. So much in the academic field as in the familiar, the mediation acquires, in our view, more efficiency when it translates into models of behaviour and not only in verbal recommendations, when it is accompanied by emotional complicity or when the substantive aspects of one’s life. University teaching practices have to provide to the students rewarding experiences of reading.

  16. Towards a covariant canonical formulation for closed topological defects without boundaries

    CERN Document Server

    Cartas-Fuentevilla, R

    2002-01-01

    On the basis of the covariant description of the canonical formalism for quantization, we present the basic elements of the symplectic geometry for a restricted class of topological defects propagating on a curved background spacetime. We discuss the future extensions of the present results.

  17. Canonical Correlational Models of Students' Perceptions of Assessment Tasks, Motivational Orientations, and Learning Strategies

    Science.gov (United States)

    Alkharusi, Hussain

    2013-01-01

    The present study aims at deriving correlational models of students' perceptions of assessment tasks, motivational orientations, and learning strategies using canonical analyses. Data were collected from 198 Omani tenth grade students. Results showed that high degrees of authenticity and transparency in assessment were associated with positive…

  18. Association of transient receptor potential canonical type 3 (TRPC3) channel transcripts with proinflammatory cytokines

    DEFF Research Database (Denmark)

    Thilo, Florian; Scholze, Alexandra; Liu, Dao Yan;

    2008-01-01

    We investigated whether expression of non-selective cation channels of the transient receptor potential canonical (TRPC) channel family are associated with proinflammatory cytokines in monocytes. Using quantitative RT-PCR we studied the expression of TRPC3, interleukin-1beta (IL-1beta), and tumor...

  19. Canonical systems of differential equations with self-adjoint interface conditions on graphs

    NARCIS (Netherlands)

    de Snoo, H; Winkler, Henrik

    2005-01-01

    For n canonical systems of differential equations, the corresponding n copies of their domain [0,∞) are thought of as a graph with vertex 0. An interface condition at 0 is given by a so-called Nevanlinna pair. Explicit formulae are deduced for the spectral representation of the corresponding underly

  20. Square-integrable solutions and Weyl functions for singular canonical systems

    NARCIS (Netherlands)

    Behrndt, Jussi; Hassi, Seppo; de Snoo, Henk; Wietsma, Rudi

    2011-01-01

    Boundary value problems for singular canonical systems of differential equations of the form Jf'(t) - H(t)f(t) = lambda Delta(t)f(t), t is an element of i, lambda is an element of C, are studied in the associated Hilbert space L(Delta)(2)(i). With the help of a monotonicity principle for matrix func

  1. Two-dimensional trace-normed canonical systems of differential equations and selfadjoint interface conditions

    NARCIS (Netherlands)

    de Snoo, H; Winkler, Henrik

    2005-01-01

    The class of two-dimensional trace-normed canonical systems of differential equations on R is considered with selfadjoint interface conditions at 0. If one or both of the intervals around 0 are H-indivisible the interface conditions which give rise to selfadjoint relations (multi-valued operators) a

  2. Canons and Communities: Children and Social Cohesion in Sweden and the Netherlands

    Science.gov (United States)

    Stoltz, Pauline

    2011-01-01

    In this article I compare the lines of argumentation that are used in two public debates about the introduction of national canons in Sweden and the Netherlands. These arguments illustrate how different political actors understand the balance they think should be struck between the interests of individual children and society in obtaining social…

  3. Change detection in bi-temporal data by canonical information analysis

    DEFF Research Database (Denmark)

    Nielsen, Allan Aasbjerg; Vestergaard, Jacob Schack

    2015-01-01

    combinations with the information theoretical measure mutual information (MI). We term this type of analysis canonical information analysis (CIA). MI allows for the actual joint distribution of the variables involved and not just second order statistics. Where CCA is ideal for Gaussian data, CIA facilitates...

  4. Osteogenesis on nanoparticulate mineralized collagen scaffolds via autogenous activation of the canonical BMP receptor signaling pathway.

    Science.gov (United States)

    Ren, Xiaoyan; Bischoff, David; Weisgerber, Daniel W; Lewis, Michael S; Tu, Victor; Yamaguchi, Dean T; Miller, Timothy A; Harley, Brendan A C; Lee, Justine C

    2015-05-01

    Skeletal regenerative medicine frequently incorporates deliverable growth factors to stimulate osteogenesis. However, the cost and side effects secondary to supraphysiologic dosages of growth factors warrant investigation of alternative methods of stimulating osteogenesis for clinical utilization. In this work, we describe growth factor independent osteogenic induction of human mesenchymal stem cells (hMSCs) on a novel nanoparticulate mineralized collagen glycosaminoglycan scaffold (MC-GAG). hMSCs demonstrated elevated osteogenic gene expression and mineralization on MC-GAG with minimal to no effect upon addition of BMP-2 when compared to non-mineralized scaffolds (Col-GAG). To investigate the intracellular pathways responsible for the increase in osteogenesis, we examined the canonical and non-canonical pathways downstream from BMP receptor activation. Constitutive Smad1/5 phosphorylation with nuclear translocation occurred on MC-GAG independent of BMP-2, whereas Smad1/5 phosphorylation depended on BMP-2 stimulation on Col-GAG. When non-canonical BMPR signaling molecules were examined, ERK1/2 phosphorylation was found to be decreased in MC-GAG but elevated in Col-GAG. No differences in Smad2/3 or p38 activation were detected. Collectively, these results demonstrated that MC-GAG scaffolds induce osteogenesis without exogenous BMP-2 addition via endogenous activation of the canonical BMP receptor signaling pathway.

  5. On canonical cylinder sections for accurate determination of contact angle in microgravity

    Science.gov (United States)

    Concus, Paul; Finn, Robert; Zabihi, Farhad

    1992-01-01

    Large shifts of liquid arising from small changes in certain container shapes in zero gravity can be used as a basis for accurately determining contact angle. Canonical geometries for this purpose, recently developed mathematically, are investigated here computationally. It is found that the desired nearly-discontinuous behavior can be obtained and that the shifts of liquid have sufficient volume to be readily observed.

  6. Generalized canonical correlation analysis of matrices with missing rows : A simulation study

    NARCIS (Netherlands)

    van de Velden, Michel; Bijmolt, Tammo H. A.

    2006-01-01

    A method is presented for generalized canonical correlation analysis of two or more matrices with missing rows. The method is a combination of Carroll's (1968) method and the missing data approach of the OVERALS technique (Van der Burg, 1988). In a simulation study we assess the performance of the m

  7. Optimal Class Separation in Hyperspectral Image Data: Iterated Canonical Discriminant Analysis

    DEFF Research Database (Denmark)

    Nielsen, Allan Aasbjerg; Müller, Andreas

    This paper describes canonical discriminant analysis and sketches an iterative version which is then applied to obtain optimal separation between a region, here examplified by either “water” or “wood/trees” and the rest of a HyMap image. We show that the iterative version greatly enhances the sep...

  8. From canon to fanon and back again: The epic journey of "Supernatural" and its fans

    Directory of Open Access Journals (Sweden)

    Melissa Gray

    2010-03-01

    Full Text Available The relationship between Supernatural and its fans is tested through the suspension of disbelief with its evolving mythos and through its canonical portrayal of fandom. This testing has allowed the relationship to grow deeper and more extensive than most similar relationships, and while it is not always smooth, it remains largely positive.

  9. Testing the Canon: Student Responses to Texts by Medieval Women in English Literature Surveys.

    Science.gov (United States)

    Hawkins, Ann R.

    While there has been a great deal of debate about enlarging the canon, less attention has been paid to how students respond to "new" literary figures such as Margery Kempe and Julian of Norwich, or to how instructors should incorporate them into an already cramped literature survey course. Instructors must consider some questions that…

  10. Edward Said's Worldliness, Amateurism and Heterotopia: Negotiating the Interdisciplinarity of Literary Theory, Canonicity, and Paradigm

    Science.gov (United States)

    Abu-Shomar, Ayman

    2016-01-01

    Literary criticism nowadays is essentially crossing the boundaries of disciplinarity and canonicity where literary theory has increasingly been shaped by overlapping concepts and branching out of theories as well as whipping out the limitations imposed by theory itself. The post-conditions of contemporaneity have imposed a view of reading and…

  11. Bäcklund-Darboux Transformation for Non-Isospectral Canonical System and Riemann-Hilbert Problem

    Directory of Open Access Journals (Sweden)

    Alexander Sakhnovich

    2007-03-01

    Full Text Available A GBDT version of the Bäcklund-Darboux transformation is constructed for a non-isospectral canonical system, which plays essential role in the theory of random matrix models. The corresponding Riemann-Hilbert problem is treated and some explicit formulas are obtained. A related inverse problem is formulated and solved.

  12. Hard, charged spheres in spherical pores. Grand canonical ensemble Monte Carlo calculations

    DEFF Research Database (Denmark)

    Sloth, Peter; Sørensen, T. S.

    1992-01-01

    A model consisting of hard charged spheres inside hard spherical pores is investigated by grand canonical ensemble Monte Carlo calculations. It is found that the mean ionic density profiles in the pores are almost the same when the wall of the pore is moderately charged as when it is uncharged...

  13. Canonical Analysis of the WISC and ITPA: A Reanalysis of the Wakefield and Carlson Data

    Science.gov (United States)

    Pielstick, N. L.; Thorndike, Robert M.

    1976-01-01

    Reanalysis of Wakefield and Carlson's data confirmed canonical correlations of .84 and .69, but analysis of redundancies revealed that only 34 percent of the total WISC subtest variance is redundant with the ITPA and 39 percent of the ITPA subtest variance is redundant with the WISC. (Author)

  14. Transient receptor potential canonical type 3 channels and blood pressure in humans

    DEFF Research Database (Denmark)

    Thilo, Florian; Baumunk, Daniel; Krause, Hans;

    2009-01-01

    There is evidence that transient receptor potential canonical type 3 (TRPC3) cation channels are involved in the regulation of blood pressure, but this has not been studied using human renal tissue. We tested the hypothesis that the expression of TRPC3 in human renal tissue is associated with blood...

  15. Canonical quantization of the WZW model with defects and Chern-Simons theory

    DEFF Research Database (Denmark)

    Sarkissian, Gor

    2010-01-01

    We perform canonical quantization of the WZW model with defects and permutation branes. We establish symplectomorphism between phase space of WZW model with $N$ defects on cylinder and phase space of Chern-Simons theory on annulus times $R$ with $N$ Wilson lines, and between phase space of WZW mo...

  16. Canonical quantization of lattice Higgs-Yang-Mills fields: Krein essential selfadjointness of the Hamiltonian

    Science.gov (United States)

    Challifour, John L.; Timko, Edward J.

    2016-06-01

    Using a Krein indefinite metric in Fock space, the Hamiltonian for cut-off models of canonically quantized Higgs-Yang-Mills fields interpolating between the Gupta-Bleuler-Feynman and Landau gauges is shown to be essentially maximal accretive and essentially Krein selfadjoint.

  17. THE EXISTENCE AND MOMENTS OF CANONICAL BRANCHING CHAIN IN RANDOM ENVIRONMENT

    Institute of Scientific and Technical Information of China (English)

    胡迪鹤

    2004-01-01

    The concepts of branching chain in random environmnet and canonical branching chain in random environment axe introduced. Moreover the existence of these chains is proved. Finally the exact formulas of mathematical expectation and variance of branching chain in random environment axe also given.

  18. Canonical BMP Signaling Pathway And Mammalian Lung Development%经典BMP信号通路与哺乳动物肺器官发育

    Institute of Scientific and Technical Information of China (English)

    肖爱平; 滕鸿琦; 李小兵; 张明凤

    2012-01-01

      肺器官发育是上皮和间充质相互作用的过程,由多条信号通路共同调控。已知经典BMP信号通路调控了细胞的增殖、凋亡及分化过程,对哺乳动物肺器官形态发生极为重要。在小鼠等模式生物上研究发现,它参与了哺乳动物肺器官发育的调控过程。本文综合了近年来经典BMP信号通路成员在哺乳动物肺器官发育过程中的表达变化、作用功能及表达异常可能诱发的肺部疾病,以期为研究经典BMP信号通路调控人类肺器官发育的分子机制及相关肺部疾病的诊治奠定基础。%  Lung development is a consequence of interaction between epithelium and mesenchyme,which is regulated by several sig-naling pathways. It is well known that the canonical BMP signal pathway plays an important role in the regulation of cell proliferation, apoptosis and differentiation. They are also found to play pivotal roles in morphogenesis of mammalian lung. Recent studies on model organisms,such as mouse and rat,verified that the canonical BMP signal pathway participated in the regulation of mammalian lung development. This review has summarized the main recent research findings on the role of canonical BMP signaling components in the regulation of mammalian lung development. The gene expression and function in all members of canonical BMP signaling pathway, and the possible lung diseases induced by abnormal expression of canonical BMP signaling components during the mammalian lung development were emphasized to state. It’s anticipated to provide valuable information for further illustration of the molecular mecha-nisms of BMP signals in the regulation of human lung development,as well as will be in favor of finding the way to diagnose and cure human lung diseases.

  19. 经典WNT信号通路与哺乳动物肺器官发育%Canonical WNT signaling pathway and mammalian lung development

    Institute of Scientific and Technical Information of China (English)

    施珏平; 滕鸿琦; 肖爱平; 李小兵; 张明凤

    2011-01-01

    Lung development is a consequence of interaction between epithelium and mesenchyme, which is regulated by several signaling pathways. It is well known that the canonical WNT signal pathway plays an important role in the regulation of cell proliferation, apoptosis and differentiation. Recent studies on model organisms, such as mouse and rat, verified that the canonical WNT signal pathway participated in the regulation of mammalian lung development. This review has summarized the main recent research findings on the role of canonical WNT signaling components in the regulation of mammalian lung development. The gene expression and function in all members of canonical WNT signaling pathway, and the possible lung diseases induced by abnormal expression of canonical WNT signaling components during the mammalian lung development were emphasized to state. This review will provide valuable information for further illustration of the molecular mechanisms of WNT signals in the regulation of human lung development, as well as will be in favor of finding the way to diagnose and cure human lung diseases.%肺器官发育是上皮和间充质相互作用的过程,由多条信号通路共同调控.已知经典WNT信号通路对细胞的增殖、凋亡和分化起着重要的调控作用,在小鼠等模式生物上研究发现,它也参与了哺乳动物肺器官发育的调控过程.综述近年来经典WNT信号通路成员在哺乳动物肺器官发育过程中的表达变化、作用功能及表达异常可能诱发的肺部疾病,以期为研究经典WNT信号通路调控人类肺器官发育的分子机制及相关肺部疾病的诊治奠定基础.

  20. Coherent state quantization of quaternions

    Energy Technology Data Exchange (ETDEWEB)

    Muraleetharan, B., E-mail: bbmuraleetharan@jfn.ac.lk, E-mail: santhar@gmail.com [Department of Mathematics and Statistics, University of Jaffna, Thirunelveli (Sri Lanka); Thirulogasanthar, K., E-mail: bbmuraleetharan@jfn.ac.lk, E-mail: santhar@gmail.com [Department of Computer Science and Software Engineering, Concordia University, 1455 De Maisonneuve Blvd. West, Montreal, Quebec H3G 1M8 (Canada)

    2015-08-15

    Parallel to the quantization of the complex plane, using the canonical coherent states of a right quaternionic Hilbert space, quaternion field of quaternionic quantum mechanics is quantized. Associated upper symbols, lower symbols, and related quantities are analyzed. Quaternionic version of the harmonic oscillator and Weyl-Heisenberg algebra are also obtained.

  1. Canonical Genetic Signatures of the Adult Human Brain

    Science.gov (United States)

    Hawrylycz, Michael; Miller, Jeremy A.; Menon, Vilas; Feng, David; Dolbeare, Tim; Guillozet-Bongaarts, Angela L.; Jegga, Anil G.; Aronow, Bruce J.; Lee, Chang-Kyu; Bernard, Amy; Glasser, Matthew F.; Dierker, Donna L.; Menche, Jörge; Szafer, Aaron; Collman, Forrest; Grange, Pascal; Berman, Kenneth A.; Mihalas, Stefan; Yao, Zizhen; Stewart, Lance; Barabási, Albert-László; Schulkin, Jay; Phillips, John; Ng, Lydia; Dang, Chinh; Haynor, David R.; Jones, Allan; Van Essen, David C.; Koch, Christof; Lein, Ed

    2015-01-01

    The structure and function of the human brain are highly stereotyped, implying a conserved molecular program responsible for its development, cellular structure, and function. We applied a correlation-based metric of “differential stability” (DS) to assess reproducibility of gene expression patterning across 132 structures in six individual brains, revealing meso-scale genetic organization. The highest DS genes are highly biologically relevant, with enrichment for brain-related biological annotations, disease associations, drug targets, and literature citations. Using high DS genes we identified 32 anatomically diverse and reproducible gene expression signatures, which represent distinct cell types, intracellular components, and/or associations with neurodevelopmental and neurodegenerative disorders. Genes in neuron-associated compared to non-neuronal networks showed higher preservation between human and mouse; however, many diversely-patterned genes displayed dramatic shifts in regulation between species. Finally, highly consistent transcriptional architecture in neocortex is correlated with resting state functional connectivity, suggesting a link between conserved gene expression and functionally relevant circuitry. PMID:26571460

  2. The traditional diagnosis and treatment of respiratory diseases: a description from Avicenna's Canon of Medicine.

    Science.gov (United States)

    Hashemi, Seyyed Mehdi; Raza, Mohsin

    2009-12-01

    This article presents selected text on respiratory medicine from the famous book of medicine, Al-Qanun fi al-Tibb (the Canon of Medicine) by Avicenna (981-1037 AD), which was taught for 600 years as a standard text of medicine across medieval Europe. The authentic manuscript of the Canon of Medicine is located in the Central Library of the Tehran University of Medical Sciences, and the section on respiratory diseases was studied for the most relevant information - information that would be informative and interesting for present day physicians and pulmonologists. The results of the analysis are presented in the article. Respiratory diseases are discussed in depth in volume 3 of the Canon of Medicine. Avicenna discusses in detail the functional anatomy and physiopathology of the pulmonary diseases that were known in his time. He also describes the signs and symptoms of various respiratory diseases and conditions in the five chapters of volume 3 (breathing, voice, cough and hemoptysis, internal wounds and inflammations and principles of treatments) that are remarkably similar to those of modern pulmonary medicine. In addition, the herbal and nonherbal treatment of respiratory diseases and their signs and symptoms, mentioned in volume 2 of the Canon of Medicine, is also presented. In the time of Avicenna, the presentation of respiratory diseases, their treatment and their prognosis was much different than in modern times. There was more reliance on history, physical examination (which was mostly based on visual observation), individual variation, environmental factors, diet, and so on, for diagnosis and treatment. Nevertheless, going through a popular historic text such as the Canon of Medicine adds to our knowledge of the developments in the area of respiratory medicine at the time of Avicenna.

  3. The “Mostra del Quarantennio” and the Canon of Modern Art at the Venice Biennale in the Interwar Period

    Directory of Open Access Journals (Sweden)

    Laura Moure Cecchini

    2016-12-01

    Full Text Available In 1935 the Venice Biennale organized an atypical exhibition commemorating its 40th anniversary. The “Mostra dei Quarant’anni” was mostly devoted to art from the Triveneto. Yet four rooms showed works by European artists who had exhibited in the Biennale, and were part of the collections of the Gallerie d’Arte Moderna in Rome and Venice. The show refl ected on the evolution of modern art and of the Biennale between 1895 and 1935, exemplifying the aesthetic criteria of Italian public collections at the time. It included many artists that are still considered part of the modernist canon but most of them are now all but forgotten. It thus represents an optimal case study to analyze renegotiations of the artistic canon. Furthermore, the “Mostra” played a key role in re-defi ning the international role of Venice within fascist artistic organization. As the “Mostra” took place in the gap year between two Biennales and received little support from governmental institutions, it is generally overlooked in the literature on the period. Yet, on the basis of unpublished archival documentation and of the digital reconstruction of these rooms, this paper argues that the “Mostra dei Quarant’anni” is crucial for our understanding of the history of the Biennale and of the cultural policies of the fascist state. Nel 1935 la Biennale di Venezia ha organizzato una mostra atipica per commemorare il proprio 40° anniversario. La “Mostra dei Quarant’anni” era in gran parte dedicata all’arte dal Triveneto. Eppure quattro sale espongono opere di artisti europei che furono in mostra alla Biennale, e divennero parte delle collezioni della galleria d’Arte Moderna di Roma e Venezia. La Mostra rifl ette sull’evoluzione dell’arte moderna e della Biennale tra il 1895 e il 1935, esemplifi cando i criteri estetici adottati a quell’epoca in collezioni pubbliche italiane. Vengono esposti molti artisti ancora considerati parte del canone

  4. Non-Canonical Statistics of a Spin-Boson Model: Theory and Exact Monte-Carlo Simulations

    CERN Document Server

    Lee, Chee Kong; Gong, Jiangbin

    2012-01-01

    Equilibrium canonical distribution in statistical mechanics assumes weak system-bath coupling (SBC). In real physical situations this assumption can be invalid and equilibrium quantum statistics of the system may be non-canonical. By exploiting both polaron transformation and perturbation theory in a spin-boson model, an analytical treatment is advocated to study non-canonical statistics of a two-level system at arbitrary temperature and for arbitrary SBC strength, yielding theoretical results in agreement with exact Monte-Carlo simulations. In particular, the eigen-representation of system's reduced density matrix is used to quantify non-canonical statistics as well as the quantumness of the open system. For example, it is found that irrespective of SBC strength, non-canonical statistics enhances as temperature decreases but vanishes at high temperature.

  5. Manganese toxicity to tropical freshwater species in low hardness water.

    Science.gov (United States)

    Harford, Andrew J; Mooney, Thomas J; Trenfield, Melanie A; van Dam, Rick A

    2015-12-01

    Elevated manganese (Mn) is a common contaminant issue for mine water discharges, and previous studies have reported that its toxicity is ameliorated by H(+), Ca(2+), and Mg(2+) ions. In the present study, the toxicity of Mn was assessed in a high risk scenario, that is, the slightly acidic, soft waters of Magela Creek, Kakadu National Park, Northern Territory, Australia. Toxicity estimates were derived for 6 tropical freshwater species (Chlorella sp., Lemna aequinoctialis, Amerianna cumingi, Moinodaphnia macleayi, Hydra viridissima, and Mogurnda mogurnda). Low effect chronic inhibition concentration (IC10) and acute lethal concentration (LC05) values ranged between 140 μg L(-1) and 80,000 μg L(-1), with 3 of the species tested (M. macleayi, A. cumingi, and H. viridissima) being more sensitive to Mn than all but 1 species in the international literature (Hyalella azteca). A loss of Mn was observed on the final day for 2 of the H. viridissima toxicity tests, which may be a result of the complex speciation of Mn and biological oxidation. International data from toxicity tests conducted in natural water with a similar physicochemistry to Magela Creek water were combined with the present study's data to increase the sample size to produce a more reliable species sensitivity distribution. A 99% protection guideline value of 73 μg L(-1) (33-466 μg L(-1)) was derived; the low value of this guideline value reflects the higher toxicity of Mn in slightly acidic soft waters.

  6. Storage of hydrogen at 303 K in graphite slitlike pores from grand canonical Monte Carlo simulation.

    Science.gov (United States)

    Kowalczyk, Piotr; Tanaka, Hideki; Hołyst, Robert; Kaneko, Katsumi; Ohmori, Takumi; Miyamoto, Junichi

    2005-09-15

    Grand canonical Monte Carlo (GCMC) simulations were used for the modeling of the hydrogen adsorption in idealized graphite slitlike pores. In all simulations, quantum effects were included through the Feynman and Hibbs second-order effective potential. The simulated surface excess isotherms of hydrogen were used for the determination of the total hydrogen storage, density of hydrogen in graphite slitlike pores, distribution of pore sizes and volumes, enthalpy of adsorption per mole, total surface area, total pore volume, and average pore size of pitch-based activated carbon fibers. Combining experimental results with simulations reveals that the density of hydrogen in graphite slitlike pores at 303 K does not exceed 0.014 g/cm(3), that is, 21% of the liquid-hydrogen density at the triple point. The optimal pore size for the storage of hydrogen at 303 K in the considered pore geometry depends on the pressure of storage. For lower storage pressures, p optimal pore width is equal to a 2.2 collision diameter of hydrogen (i.e., 0.65 nm), whereas, for p congruent with 50MPa, the pore width is equal to an approximately 7.2 collision diameter of hydrogen (i.e., 2.13 nm). For the wider pores, that is, the pore width exceeds a 7.2 collision diameter of hydrogen, the surface excess of hydrogen adsorption is constant. The importance of quantum effects is recognized in narrow graphite slitlike pores in the whole range of the hydrogen pressure as well as in wider ones at high pressures of bulk hydrogen. The enthalpies of adsorption per mole for the considered carbonaceous materials are practically constant with hydrogen loading and vary within the narrow range q(st) congruent with 7.28-7.85 kJ/mol. Our systematic study of hydrogen adsorption at 303 K in graphite slitlike pores gives deep insight into the timely problem of hydrogen storage as the most promising source of clean energy. The calculated maximum storage of hydrogen is equal to approximately 1.4 wt %, which is far from

  7. Quantum states with strong positive partial transpose

    Science.gov (United States)

    Chruściński, Dariusz; Jurkowski, Jacek; Kossakowski, Andrzej

    2008-02-01

    We construct a large class of bipartite M⊗N quantum states which defines a proper subset of states with positive partial transposes (PPTs). Any state from this class has PPT but the positivity of its partial transposition is recognized with respect to canonical factorization of the original density operator. We propose to call elements from this class states with strong positive partial transposes (SPPTs). We conjecture that all SPPT states are separable.

  8. Relationship between organisational commitment and burnout syndrome: a canonical correlation approach.

    Science.gov (United States)

    Enginyurt, Ozgur; Cankaya, Soner; Aksay, Kadir; Tunc, Taner; Koc, Bozkurt; Bas, Orhan; Ozer, Erdal

    2016-04-01

    Objective Burnout syndrome can significantly reduce the performance of health workers. Although many factors have been identified as antecedents of burnout, few studies have investigated the role of organisational commitment in its development. The purpose of the present study was to examine the relationships between subdimensions of burnout syndrome (emotional exhaustion, depersonalisation and personal accomplishment) and subdimensions of organisational commitment (affective commitment, continuance commitment and normative commitment). Methods The present study was a cross-sectional survey of physicians and other healthcare employees working in the Ministry of Health Ordu University Education and Research Hospital. The sample consisted of 486 healthcare workers. Data were collected using the Maslach Burnout Inventory and the Organisation Commitment Scale, and were analysed using the canonical correlation approach. Results The first of three canonical correlation coefficients between pairs of canonical variables (Ui , burnout syndrome and Vi, organisational commitment) was found to be statistically significant. Emotional exhaustion was found to contribute most towards the explanatory capacity of canonical variables estimated from the subdimensions of burnout syndrome, whereas affective commitment provided the largest contribution towards the explanatory capacity of canonical variables estimated from the subdimensions of organisational commitment. Conclusions The results of the present study indicate that affective commitment is the primary determinant of burnout syndrome in healthcare professionals. What is known about the topic? Organisational commitment and burnout syndrome are the most important criteria in predicting health workforce performance. An increasing number of studies in recent years have clearly indicated the field's continued relevance and importance. Conversely, canonical correlation analysis (CCA) is a technique for describing the relationship

  9. BOOK REVIEW: Canonical Gravity and Applications: Cosmology, Black Holes, and Quantum Gravity Canonical Gravity and Applications: Cosmology, Black Holes, and Quantum Gravity

    Science.gov (United States)

    Husain, Viqar

    2012-03-01

    Research on quantum gravity from a non-perturbative 'quantization of geometry' perspective has been the focus of much research in the past two decades, due to the Ashtekar-Barbero Hamiltonian formulation of general relativity. This approach provides an SU(2) gauge field as the canonical configuration variable; the analogy with Yang-Mills theory at the kinematical level opened up some research space to reformulate the old Wheeler-DeWitt program into what is now known as loop quantum gravity (LQG). The author is known for his work in the LQG approach to cosmology, which was the first application of this formalism that provided the possibility of exploring physical questions. Therefore the flavour of the book is naturally informed by this history. The book is based on a set of graduate-level lectures designed to impart a working knowledge of the canonical approach to gravitation. It is more of a textbook than a treatise, unlike three other recent books in this area by Kiefer [1], Rovelli [2] and Thiemann [3]. The style and choice of topics of these authors are quite different; Kiefer's book provides a broad overview of the path integral and canonical quantization methods from a historical perspective, whereas Rovelli's book focuses on philosophical and formalistic aspects of the problems of time and observables, and gives a development of spin-foam ideas. Thiemann's is much more a mathematical physics book, focusing entirely on the theory of representing constraint operators on a Hilbert space and charting a mathematical trajectory toward a physical Hilbert space for quantum gravity. The significant difference from these books is that Bojowald covers mainly classical topics until the very last chapter, which contains the only discussion of quantization. In its coverage of classical gravity, the book has some content overlap with Poisson's book [4], and with Ryan and Shepley's older work on relativistic cosmology [5]; for instance the contents of chapter five of the

  10. Parameter and State Estimator for State Space Models

    Directory of Open Access Journals (Sweden)

    Ruifeng Ding

    2014-01-01

    Full Text Available This paper proposes a parameter and state estimator for canonical state space systems from measured input-output data. The key is to solve the system state from the state equation and to substitute it into the output equation, eliminating the state variables, and the resulting equation contains only the system inputs and outputs, and to derive a least squares parameter identification algorithm. Furthermore, the system states are computed from the estimated parameters and the input-output data. Convergence analysis using the martingale convergence theorem indicates that the parameter estimates converge to their true values. Finally, an illustrative example is provided to show that the proposed algorithm is effective.

  11. Gluing together Proof Environments: Canonical extensions of LF Type Theories featuring Locks

    Directory of Open Access Journals (Sweden)

    Furio Honsell

    2015-07-01

    Full Text Available We present two extensions of the LF Constructive Type Theory featuring monadic locks. A lock is a monadic type construct that captures the effect of an external call to an oracle. Such calls are the basic tool for gluing together diverse Type Theories and proof development environments. The oracle can be invoked either to check that a constraint holds or to provide a suitable witness. The systems are presented in the canonical style developed by the CMU School. The first system, CLLFP, is the canonical version of the system LLFP, presented earlier by the authors. The second system, CLLFP?, features the possibility of invoking the oracle to obtain a witness satisfying a given constraint. We discuss encodings of Fitch-Prawitz Set theory, call-by-value lambda-calculi, and systems of Light Linear Logic. Finally, we show how to use Fitch-Prawitz Set Theory to define a type system that types precisely the strongly normalizing terms.

  12. Canonical structure of BHT massive gravity in warped AdS3 sector

    Science.gov (United States)

    Mahdavian Yekta, Davood

    2016-08-01

    We investigate the asymptotic structure of the three dimensional Warped Anti-de Sitter (WAdS3) black holes in the Bergshoeff-Hohm-Townsend (BHT) massive gravity using the canonical Hamiltonian formalism. We define the canonical asymptotic gauge generators, which produce the conserved charges and the asymptotic symmetry group for the WAdS3 black holes. The attained symmetry group is described by a semi-direct sum of a Virasoro and a Kač-Moody algebra. Using the Sugawara construction, we obtain a direct sum of two Virasoro algebras. We show that not only the asymptotic conserved charges satisfy the first law of black hole thermodynamics, but also they lead to the expected Smarr formula for the WAdS3 black holes. We also show that the black hole's entropy obeys the Cardy formula of the dual conformal field theory (CFT).

  13. Canonical structure of BHT massive gravity in warped AdS3 sector

    CERN Document Server

    Yekta, Davood Mahdavian

    2016-01-01

    We investigate the asymptotic structure of the three dimensional warped anti de sitter black holes in the Bergshoeff, Hohm and Townsend massive gravity using the canonical Hamiltonian formalism. We define the canonical asymptotic guage generators, which produce the conserved charges and the asymptotic symmetry group for the warped anti de sitter black holes. The attained symmetry group is described by a semi direct sum of a Virasoro and a KacMoody algebra. Using the Sugawara construction, we obtain a direct sum of two Virasoro algebras. We show that not only the asymptotic conserved charges satisfy the first law of black hole thermodynamics, but also they lead to the expected Smarr formula for the warped anti de sitter black holes. We also show that the black hole entropy obeys the Cardy formula of the dual conformal field theory .

  14. Dark Matter as a Relativistic Inertial Effect in Einstein Canonical Gravity?

    CERN Document Server

    Lusanna, Luca

    2010-01-01

    After the study of non-inertial frames in special relativity with emphasis on the problem of clock synchronization (i.e. of how to define 3-space), an overview is given of Einstein canonical gravity in the York canonical basis and of its Hamiltonian Post-Minkowskian (PM) linearization in 3-orthogonal gauges. It is shown that the York time (the trace of the extrinsic curvature of 3-spaces) is the inertial gauge variable describing the general relativistic remnant of the clock synchronization gauge freedom. The dark matter implied by the rotation curves of galaxies can be explained with a choice of the York time implying a PM extension of the Newtonian celestial frame ICRS.

  15. Blind Identification of SIMO Wiener Systems Based on Kernel Canonical Correlation Analysis

    Science.gov (United States)

    Van Vaerenbergh, Steven; Via, Javier; Santamaria, Ignacio

    2013-05-01

    We consider the problem of blind identification and equalization of single-input multiple-output (SIMO) nonlinear channels. Specifically, the nonlinear model consists of multiple single-channel Wiener systems that are excited by a common input signal. The proposed approach is based on a well-known blind identification technique for linear SIMO systems. By transforming the output signals into a reproducing kernel Hilbert space (RKHS), a linear identification problem is obtained, which we propose to solve through an iterative procedure that alternates between canonical correlation analysis (CCA) to estimate the linear parts, and kernel canonical correlation (KCCA) to estimate the memoryless nonlinearities. The proposed algorithm is able to operate on systems with as few as two output channels, on relatively small data sets and on colored signals. Simulations are included to demonstrate the effectiveness of the proposed technique.

  16. El Canon en el Arte. Reglas y Prescripciones en Torno a la Figura Humana

    OpenAIRE

    Bautista Durán, Antonio

    1994-01-01

    El objetivo de nuestra tesis es la aclaración, conceptualización y definición más correcta del concepto canon para el arte plástico figurativo: la justificación de este objetivo es el interés docente dentro de los estudios de bellas artes, que tiene este tema para la enseñanza de la anatomía artística. La incorrecta conceptualización general del término canon, que siempre lo reduce a proporción, no explica que los resultados plásticos figurativos canónicos, sean tan semejantes, e implica que ...

  17. Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth.

    Science.gov (United States)

    Waaler, Jo; Machon, Ondrej; von Kries, Jens Peter; Wilson, Steven Ray; Lundenes, Elsa; Wedlich, Doris; Gradl, Dietmar; Paulsen, Jan Erik; Machonova, Olga; Dembinski, Jennifer L; Dinh, Huyen; Krauss, Stefan

    2011-01-01

    Canonical Wnt signaling is deregulated in several types of human cancer where it plays a central role in tumor cell growth and progression. Here we report the identification of 2 new small molecules that specifically inhibit canonical Wnt pathway at the level of the destruction complex. Specificity was verified in various cellular reporter systems, a Xenopus double-axis formation assay and a gene expression profile analysis. In human colorectal cancer (CRC) cells, the new compounds JW67 and JW74 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1. Notably, AXIN2 protein levels were strongly increased after compound exposure. Long-term treatment with JW74 inhibited the growth of tumor cells in both a mouse xenograft model of CRC and in Apc(Min) mice (multiple intestinal neoplasia, Min). Our findings rationalize further preclinical and clinical evaluation of these new compounds as novel modalities for cancer treatment.

  18. Canonical transfer and multiscale energetics for primitive and quasi-geostrophic atmospheres

    CERN Document Server

    Liang, X San

    2016-01-01

    The past years have seen the success of a novel multiscale energetic formalism in a variety of ocean and engineering fluid applications. In a self-contained way, this study introduces it to the atmospheric dynamical diagnostics, with important theoretical updates. Multiscale energy equations are derived using a new analysis apparatus, namely, multiscale window transform, with respect to both the primitive equation and quasi-geostrophic models. A reconstruction of the "atomic" energy fluxes on the multiple scale windows allows for a natural and unique separation of the in-scale transports and cross-scale transfers from the intertwined nonlinear processes. The resulting energy transfers bear a Lie bracket form, reminiscent of the Poisson bracket in Hamiltonian mechanics, we hence would call them "canonical". A canonical transfer process is a mere redistribution of energy among scale windows, without generating or destroying energy as a whole. By classification, a multiscale energetic cycle comprises of availabl...

  19. Nitrogen removal and microbial characteristics in CANON biofilters fed with different ammonia levels.

    Science.gov (United States)

    Liang, Yuhai; Li, Dong; Zhang, Xiaojing; Zeng, Huiping; Yang, Zhuo; Cui, Shaoming; Zhang, Jie

    2014-11-01

    The nitrogen removal performance and microbial characteristics of four completely autotrophic nitrogen removal over nitrite (CANON) biofilters were investigated. These four reactors were simultaneously seeded from a stable CANON biofilter with a seeding ratio of 1:1, which were fed with different ammonia levels. Results suggested that with the ammonia of 200-400 mg L(-1), aerobic ammonia-oxidizing bacteria (AerAOB) and anaerobic ammonia-oxidizing bacteria (AnAOB) could perform harmonious work. The bioactivity and population of the two groups of bacteria were both high, which then resulted in excellent nitrogen removal, while too low or too high ammonia would both lead to worse performance. When ammonia was too high, the bioactivity, biodiversity and population of AerAOB all decreased and then resulted in the lowest nitrogen removal. Nitrosomonas and Candidatus Brocadia were detected as predominant functional microbes in all the four reactors. Finally, strategies for treating sewage with different ammonia levels were proposed.

  20. Ambiguities in second-order cosmological perturbations for non-canonical scalar fields

    CERN Document Server

    Appignani, Corrado; Shankaranarayanan, S

    2010-01-01

    Over the last few years, it was realised that non-canonical scalar fields can lead to the accelerated expansion in the early universe. The primordial spectrum in these scenarios not only shows near scale-invariance consistent with CMB observations,but also large primordial non-Gaussianity. Second-order perturbation theory is the primary theoretical tool to investigate such non-Gaussianity. However, it is still uncertain which quantities are gauge-invariant at second-order and their physical understanding therefore remains unclear. As an attempt to understand second order quantities, we consider a general non-canonical scalar field, minimally coupled to gravity, on the unperturbed FRW background where metric fluctuations are neglected a priori. In this simplified set-up, we show that there arise ambiguities in the expressions of physically relevant quantities, such as the effective speeds of the perturbations. Further, the stress tensor and energy density display a potential instability which is not present at...

  1. Microbial community distribution and activity dynamics of granular biomass in a CANON reactor

    DEFF Research Database (Denmark)

    Vázquez-Padín, Jose; Mosquera-Corral, Anuska; Campos, Jose Luis

    2010-01-01

    The application of microelectrodes to measure oxygen and nitrite concentrations inside granules operated at 20 °C in a CANON (Complete Autotrophic Nitrogen-removal Over Nitrite) reactor and the application of the FISH (Fluorescent In Situ Hybridization) technique to cryosectioned slices of these ......The application of microelectrodes to measure oxygen and nitrite concentrations inside granules operated at 20 °C in a CANON (Complete Autotrophic Nitrogen-removal Over Nitrite) reactor and the application of the FISH (Fluorescent In Situ Hybridization) technique to cryosectioned slices...... (Lgranule)-1 d-1. Anammox activity was registered between 400 and 1000 μm depth inside the granules. The nitrogen removal capacity of the studied sequencing batch reactor containing the granular biomass was of 0.5 g N L-1 d-1. This value is similar to the mean nitrogen removal rate obtained from...... time of the reactor....

  2. Non-Canonical EZH2 Transcriptionally Activates RelB in Triple Negative Breast Cancer

    Science.gov (United States)

    Lawrence, Cortney L.; Baldwin, Albert S.

    2016-01-01

    Enhancer of zeste homology 2 (EZH2) is the methyltransferase component of the polycomb repressive complex (PRC2) which represses gene transcription via histone H3 trimethylation at lysine 23 (H3K27me3). EZH2 activity has been linked with oncogenesis where it is thought to block expression of certain tumor suppressors. Relative to a role in cancer, EZH2 functions to promote self-renewal and has been shown to be important for the tumor-initiating cell (TIC) phenotype in breast cancer. Recently a non-canonical role for EZH2 has been identified where it promotes transcriptional activation of certain genes. Here we show that EZH2, through a methyltransferase-independent mechanism, promotes the transcriptional activation of the non-canonical NF-κB subunit RelB to drive self-renewal and the TIC phenotype of triple-negative breast cancer cells. PMID:27764181

  3. Canonical integration and analysis of periodic maps using non-standard analysis and life methods

    Energy Technology Data Exchange (ETDEWEB)

    Forest, E.; Berz, M.

    1988-06-01

    We describe a method and a way of thinking which is ideally suited for the study of systems represented by canonical integrators. Starting with the continuous description provided by the Hamiltonians, we replace it by a succession of preferably canonical maps. The power series representation of these maps can be extracted with a computer implementation of the tools of Non-Standard Analysis and analyzed by the same tools. For a nearly integrable system, we can define a Floquet ring in a way consistent with our needs. Using the finite time maps, the Floquet ring is defined only at the locations s/sub i/ where one perturbs or observes the phase space. At most the total number of locations is equal to the total number of steps of our integrator. We can also produce pseudo-Hamiltonians which describe the motion induced by these maps. 15 refs., 1 fig.

  4. Canonical quantization of macroscopic electrodynamics in a linear, inhomogeneous magneto-electric medium

    CERN Document Server

    Judge, A C; Sipe, J E; de Sterke, C M

    2012-01-01

    We present a canonical quantization of macroscopic electrodynamics. The results apply to inhomogeneous media with a broad class of linear magneto-electric responses which are consistent with the Kramers-Kronig and Onsager relations. Through its ability to accommodate strong dispersion and loss, our theory provides a rigorous foundation for the study of quantum optical processes in structures incorporating metamaterials, provided these may be modeled as magneto-electric media. Previous canonical treatments of dielectric and magneto-dielectric media have expressed the electromagnetic field operators in either a Green function or mode expansion representation. Here we present our results in the mode expansion picture with a view to applications in guided wave and cavity quantum optics.

  5. Multireference quantum chemistry through a joint density matrix renormalization group and canonical transformation theory

    Science.gov (United States)

    Yanai, Takeshi; Kurashige, Yuki; Neuscamman, Eric; Chan, Garnet Kin-Lic

    2010-01-01

    We describe the joint application of the density matrix renormalization group and canonical transformation theory to multireference quantum chemistry. The density matrix renormalization group provides the ability to describe static correlation in large active spaces, while the canonical transformation theory provides a high-order description of the dynamic correlation effects. We demonstrate the joint theory in two benchmark systems designed to test the dynamic and static correlation capabilities of the methods, namely, (i) total correlation energies in long polyenes and (ii) the isomerization curve of the [Cu2O2]2+ core. The largest complete active spaces and atomic orbital basis sets treated by the joint DMRG-CT theory in these systems correspond to a (24e,24o) active space and 268 atomic orbitals in the polyenes and a (28e,32o) active space and 278 atomic orbitals in [Cu2O2]2+.

  6. Canonical-Dissipative Nonequilibrium Energy Distributions: Parameter Estimation via Implicit Moment Method, Implementation and Application

    Science.gov (United States)

    Frank, T. D.; Kim, S.; Dotov, D. G.

    2013-11-01

    Canonical-dissipative nonequilibrium energy distributions play an important role in the life sciences. In one of the most fundamental forms, such energy distributions correspond to two-parametric normal distributions truncated to the left. We present an implicit moment method involving the first and second energy moments to estimate the distribution parameters. It is shown that the method is consistent with Cohen's 1949 formula. The implementation of the algorithm is discussed and the range of admissible parameter values is identified. In addition, an application to an earlier study on human oscillatory hand movements is presented. In this earlier study, energy was conceptualized as the energy of a Hamiltonian oscillator model. The canonical-dissipative approach allows for studying the systematic change of the model parameters with oscillation frequency. It is shown that the results obtained with the implicit moment method are consistent with those derived in the earlier study by other means.

  7. Canonical structure of BHT massive gravity in warped AdS{sub 3} sector

    Energy Technology Data Exchange (ETDEWEB)

    Mahdavian Yekta, Davood, E-mail: d.mahdavian@hsu.ac.ir

    2016-08-10

    We investigate the asymptotic structure of the three dimensional Warped Anti-de Sitter (WAdS{sub 3}) black holes in the Bergshoeff–Hohm–Townsend (BHT) massive gravity using the canonical Hamiltonian formalism. We define the canonical asymptotic gauge generators, which produce the conserved charges and the asymptotic symmetry group for the WAdS{sub 3} black holes. The attained symmetry group is described by a semi-direct sum of a Virasoro and a Kač–Moody algebra. Using the Sugawara construction, we obtain a direct sum of two Virasoro algebras. We show that not only the asymptotic conserved charges satisfy the first law of black hole thermodynamics, but also they lead to the expected Smarr formula for the WAdS{sub 3} black holes. We also show that the black hole's entropy obeys the Cardy formula of the dual conformal field theory (CFT).

  8. Canonical quantum gravity in the Vassiliev invariants arena; 1, Kinematical structure

    CERN Document Server

    Di Bartolo, C; Griego, J R; Pullin, J; Bartolo, Cayetano Di; Gambini, Rodolfo; Griego, Jorge; Pullin, Jorge

    2000-01-01

    We generalize the idea of Vassiliev invariants to the spin network context, with the aim of using these invariants as a kinematical arena for a canonical quantization of gravity. This paper presents a detailed construction of these invariants (both ambient and regular isotopic) requiring a significant elaboration based on the use of Chern-Simons perturbation theory which extends the work of Kauffman, Martin and Witten to four-valent networks. We show that this space of knot invariants has the crucial property -from the point of view of the quantization of gravity- of being loop differentiable in the sense of distributions. This allows the definition of diffeomorphism and Hamiltonian constraints. We show that the invariants are annihilated by the diffeomorphism constraint. In a companion paper we elaborate on the definition of a Hamiltonian constraint, discuss the constraint algebra, and show that the construction leads to a consistent theory of canonical quantum gravity.

  9. Exploring finite density QCD phase transition with canonical approach -Power of multiple precision computation-

    CERN Document Server

    Oka, Shotaro

    2015-01-01

    The canonical approach for finite density lattice QCD has a numerical instability. This instability makes it difficult to use the method reliably at the finite real chemical potential region. We studied this instability in detail and found that it is caused by the cancellation of significant digits. In order to reduce the effect of this cancellation, we adopt the multiple precision calculation for our discrete Fourier transformation (DFT) program, and we get the canonical partition function Zc(n,T) with required accuracy. From the obtained Zc(n,T), we calculate Lee--Yang zero distribution varying the number of significant digits. As a result, some curves surround the origin in the fugacity plane, but they are moved by varying the number of significant digits. Hence, we conclude that these curves are pseudo phase transition lines, and not real ones.

  10. BRST quantization and canonical Ward identity of the supersymmetric electromagnetic interaction system

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    According to the method of path integral quantization for the canonical constrained system in Becchi-Rouet-Stora-Tyutin scheme, the supersymmetric electromagnetic interaction system was quantized. Both the Hamiltonian of the supersymmetric electromagnetic interaction system in phase space and the quantization procedure were simplified. The BRST generator was constructed, and the BRST transforma- tions of supersymmetric fields were gotten; the effective action was calculated, and the generating functional for the Green function was achieved; also, the gauge generator was constructed, and the gauge transformation of the system was ob- tained. Finally, the Ward-Takahashi identities based on the canonical Noether theorem were calculated, and two relations between proper vertices and propaga- tors were obtained.

  11. Stationary waves on nonlinear quantum graphs. II. Application of canonical perturbation theory in basic graph structures

    Science.gov (United States)

    Gnutzmann, Sven; Waltner, Daniel

    2016-12-01

    We consider exact and asymptotic solutions of the stationary cubic nonlinear Schrödinger equation on metric graphs. We focus on some basic example graphs. The asymptotic solutions are obtained using the canonical perturbation formalism developed in our earlier paper [S. Gnutzmann and D. Waltner, Phys. Rev. E 93, 032204 (2016), 10.1103/PhysRevE.93.032204]. For closed example graphs (interval, ring, star graph, tadpole graph), we calculate spectral curves and show how the description of spectra reduces to known characteristic functions of linear quantum graphs in the low-intensity limit. Analogously for open examples, we show how nonlinear scattering of stationary waves arises and how it reduces to known linear scattering amplitudes at low intensities. In the short-wavelength asymptotics we discuss how genuine nonlinear effects may be described using the leading order of canonical perturbation theory: bifurcation of spectral curves (and the corresponding solutions) in closed graphs and multistability in open graphs.

  12. Image encryption algorithm based on wavelet packet decomposition and discrete linear canonical transform

    Science.gov (United States)

    Sharma, K. K.; Jain, Heena

    2013-01-01

    The security of digital data including images has attracted more attention recently, and many different image encryption methods have been proposed in the literature for this purpose. In this paper, a new image encryption method using wavelet packet decomposition and discrete linear canonical transform is proposed. The use of wavelet packet decomposition and DLCT increases the key size significantly making the encryption more robust. Simulation results of the proposed technique are also presented.

  13. El cobro del canon por préstamo en el CSIC

    OpenAIRE

    Cottereau, Mario

    2008-01-01

    En otras ocasiones se ha hablado desde estas páginas del pago del canon por préstamo (por ejemplo, Enredadera 13 y 14) y de las acciones que se llevan a cabo desde distintos ámbitos para intentar que no se aplique en España y que la directiva europea que lo regula (Directiva 2006/115/CE) sea derogada o modificada para que no se grave un servicio bibliotecario básico.

  14. Canonical Duality Theory and Algorithms for Solving Some Challenging Problems in Global Optimization and Decision Science

    Science.gov (United States)

    2015-09-24

    19. Colloquium lecture at College of Management , National Chiao Tung University, June 22, 2012. Title: Unified Framework in Global Supply Chain and...the well-known logistic equation in population dynamical systems can be reformulated as a global optimization problem, which could have at most 2n...making, supply chain , scheduling problems, and computational mechanics, etc. Impacts to the communities: The canonical duality theory is now

  15. An actin cytoskeleton with evolutionarily conserved functions in the absence of canonical actin-binding proteins

    OpenAIRE

    Paredez, Alexander R.; Assaf, Zoe June; Sept, David; Timofejeva, Ljudmilla; Dawson, Scott C.; Wang, Chung-Ju Rachel; Cande, W. Z.

    2011-01-01

    Giardia intestinalis, a human intestinal parasite and member of what is perhaps the earliest-diverging eukaryotic lineage, contains the most divergent eukaryotic actin identified to date and is the first eukaryote known to lack all canonical actin-binding proteins (ABPs). We sought to investigate the properties and functions of the actin cytoskeleton in Giardia to determine whether Giardia actin (giActin) has reduced or conserved roles in core cellular processes. In vitro polymerization of gi...

  16. Queueing analysis of a canonical model of real-time multiprocessors

    Science.gov (United States)

    Krishna, C. M.; Shin, K. G.

    1983-01-01

    A logical classification of multiprocessor structures from the point of view of control applications is presented. A computation of the response time distribution for a canonical model of a real time multiprocessor is presented. The multiprocessor is approximated by a blocking model. Two separate models are derived: one created from the system's point of view, and the other from the point of view of an incoming task.

  17. Momentum-dependent symmetries and non-Noether conserved quantities for nonholonomic nonconservative Hamilton canonical systems

    Institute of Scientific and Technical Information of China (English)

    Fu Jing-Li; Chen Li-Qun; Chen Xian-Wei

    2006-01-01

    This paper investigates the momentum-dependent symmetries for nonholonomic nonconservative Hamilton canonical systems. The definition and determining equations of the momentum-dependent symmetries are presented, based on the invariance of differential equations under infinitesimal transformations with respect to the generalized coordinates and generalized momentums. The structure equation and the non-Noether conserved quantities of the systems are obtained. The inverse issues associated with the momentum-dependent symmetries are discussed. Finally, an example is discussed to further illustrate the applications.

  18. Repeatability Using Automatic Tracing with Canon OCT- HS100 and Zeiss Cirrus HD-OCT 5000

    OpenAIRE

    Rune Brautaset; Ulrika Birkeldh; Petra Frehr Alstig; Petra Wikén; Maria Nilsson

    2016-01-01

    Background Optical coherence tomography (OCT), can be used in clinical practice to provide high resolution cross-sectional images of the retina, optic disc and macula structure. These measurements can be useful for early detection, diagnosis, monitoring and treatment guidance for retinal diseases. Therefore, repeatability of measurements in OCT is of great importance. Methods Macula and optic disc parameters from the right eye of 30 healthy subjects were obtained twice with the Canon OCT-HS10...

  19. The monadic second-order logic of graphs XVI : Canonical graph
    decompositions

    OpenAIRE

    Courcelle, Bruno

    2005-01-01

    This article establishes that the split decomposition of graphs introduced by Cunnigham, is definable in Monadic Second-Order Logic.This result is actually an instance of a more general result covering canonical graph decompositions like the modular decomposition and the Tutte decomposition of 2-connected graphs into 3-connected components. As an application, we prove that the set of graphs having the same cycle matroid as a given 2-connected graph can be defined from this graph by Monadic Se...

  20. Canonical Wnt Signaling as a Specific Marker of Normal and Tumorigenic Mammary Stem Cells

    Science.gov (United States)

    2013-02-01

    mammary epithelium impacts glandular development . We found ductal abnormali ties; however, the phenotype was not as severe as expected. Approximately...In previous reports we have clearly showed that cells w ith activated canonical Wnt signaling are present within the mammary epithelium starting at...Wnt1 transgenic cells. We generated a mouse line in which ~-catenin is conditionally deleted in the mammary epithelium of MMTV-Wnt1 transgenic

  1. On the Problems of Construction and Statistical Inference Associated with a Generalization of Canonical Variables.

    Science.gov (United States)

    1982-02-01

    marketing 𔃻 and in most of the behavorial and social sciences. Hotelling noted the need for the extension of his canonical variables to the case of...gives the i t h minimum value of lErI among the values of r, r = r 1,...,p) of (1) , (q) the determinantal equation IS - (k-l)rSdI - 0 and a ( I

  2. Study of lattice QCD at finite chemical potential using canonical ensemble approach

    CERN Document Server

    Bornyakov, V G; Goy, V A; Molochkov, A V; Nakamura, Atsushi; Nikolaev, A A; Zakharov, V I

    2016-01-01

    New approach to computation of canonical partition functions in $N_f=2$ lattice QCD is presented. We compare results obtained by new method with results obtained by known method of hopping parameter expansion. We observe agreement between two methods indicating validity of the new method. We use results for the number density obtained in the confining and deconfining phases at imaginary chemical potential to determine the phase transition line at real chemical potential.

  3. Consistent canonical quantization of general relativity in the space of Vassiliev knot invariants

    CERN Document Server

    Di Bartolo, C; Griego, J R; Pullin, J

    2000-01-01

    We present a quantization of the Hamiltonian and diffeomorphism constraint of canonical quantum gravity in the spin network representation. The novelty consists in considering a space of wavefunctions based on the Vassiliev knot invariants. The constraints are finite, well defined, and reproduce at the level of quantum commutators the Poisson algebra of constraints of the classical theory. A similar construction can be carried out in 2+1 dimensions leading to the correct quantum theory.

  4. Quantum Deformed Canonical Transformations, W_{\\infty}-algebras and Unitary Transformations

    OpenAIRE

    Gozzi, E.; Reuter, M.

    2003-01-01

    We investigate the algebraic properties of the quantum counterpart of the classical canonical transformations using the symbol-calculus approach to quantum mechanics. In this framework we construct a set of pseudo-differential operators which act on the symbols of operators, i.e., on functions defined over phase-space. They act as operatorial left- and right- multiplication and form a $W_{\\infty}\\times W_{\\infty}$- algebra which contracts to its diagonal subalgebra in the classical limit. We ...

  5. Canonical Wnt signaling promotes early hematopoietic progenitor formation and erythroid specification during embryonic stem cell differentiation.

    Directory of Open Access Journals (Sweden)

    Anuradha Tarafdar

    Full Text Available The generation of hematopoietic stem cells (HSCs during development is a complex process linked to morphogenic signals. Understanding this process is important for regenerative medicine applications that require in vitro production of HSC. In this study we investigated the effects of canonical Wnt/β-catenin signaling during early embryonic differentiation and hematopoietic specification using an embryonic stem cell system. Our data clearly demonstrates that following early differentiation induction, canonical Wnt signaling induces a strong mesodermal program whilst maintaining a degree of stemness potential. This involved a complex interplay between β-catenin/TCF/LEF/Brachyury/Nanog. β-catenin mediated up-regulation of TCF/LEF resulted in enhanced brachyury levels, which in-turn lead to Nanog up-regulation. During differentiation, active canonical Wnt signaling also up-regulated key transcription factors and cell specific markers essential for hematopoietic specification, in particular genes involved in establishing primitive erythropoiesis. This led to a significant increase in primitive erythroid colony formation. β-catenin signaling also augmented early hematopoietic and multipotent progenitor (MPP formation. Following culture in a MPP specific cytokine cocktail, activation of β-catenin suppressed differentiation of the early hematopoietic progenitor population, with cells displaying a higher replating capacity and a propensity to form megakaryocytic erythroid progenitors. This bias towards erythroid lineage commitment was also observed when hematopoietic progenitors were directed to undergo myeloid colony formation. Overall this study underscores the importance of canonical Wnt/β-catenin signaling in mesodermal specification, primitive erythropoiesis and early hematopietic progenitor formation during hematopoietic induction.

  6. Canonical Wnt signaling promotes early hematopoietic progenitor formation and erythroid specification during embryonic stem cell differentiation.

    Science.gov (United States)

    Tarafdar, Anuradha; Dobbin, Edwina; Corrigan, Pamela; Freeburn, Robin; Wheadon, Helen

    2013-01-01

    The generation of hematopoietic stem cells (HSCs) during development is a complex process linked to morphogenic signals. Understanding this process is important for regenerative medicine applications that require in vitro production of HSC. In this study we investigated the effects of canonical Wnt/β-catenin signaling during early embryonic differentiation and hematopoietic specification using an embryonic stem cell system. Our data clearly demonstrates that following early differentiation induction, canonical Wnt signaling induces a strong mesodermal program whilst maintaining a degree of stemness potential. This involved a complex interplay between β-catenin/TCF/LEF/Brachyury/Nanog. β-catenin mediated up-regulation of TCF/LEF resulted in enhanced brachyury levels, which in-turn lead to Nanog up-regulation. During differentiation, active canonical Wnt signaling also up-regulated key transcription factors and cell specific markers essential for hematopoietic specification, in particular genes involved in establishing primitive erythropoiesis. This led to a significant increase in primitive erythroid colony formation. β-catenin signaling also augmented early hematopoietic and multipotent progenitor (MPP) formation. Following culture in a MPP specific cytokine cocktail, activation of β-catenin suppressed differentiation of the early hematopoietic progenitor population, with cells displaying a higher replating capacity and a propensity to form megakaryocytic erythroid progenitors. This bias towards erythroid lineage commitment was also observed when hematopoietic progenitors were directed to undergo myeloid colony formation. Overall this study underscores the importance of canonical Wnt/β-catenin signaling in mesodermal specification, primitive erythropoiesis and early hematopietic progenitor formation during hematopoietic induction.

  7. Getting full control of canonical correlation analysis with the AutoBiplot.CCA function

    Science.gov (United States)

    Alves, M. Rui

    2016-06-01

    Function AutoBiplot.CCA was built in R language. Given two multivariate data sets, this function carries out a conventional canonical correlation analysis, followed by the automatic production of predictive biplots based on the accuracy of readings as assessed by a mean standard predictive error and a user defined tolerance value. As the user's intervention is mainly restricted to the choice of the magnitude of the t.axis value, common misinterpretations, overestimations and adjustments between outputs and personal beliefs are avoided.

  8. THERMODYNAMICS OF THE SLOWLY ROTATING KERR-NEWMAN BLACK HOLE IN THE GRAND CANONICAL ENSEMBLE

    Institute of Scientific and Technical Information of China (English)

    CHEN JU-HUA; JING JI-LIANG

    2001-01-01

    We investigate the thermodynamics of the slowly rotating Kerr-Newman (K-N) black hole in the grand canonical ensemble with York's formalism. Some thermodynamical properties, such as the thermodynamical action, entropy,thermodynamical energy and heat capacity are studied, and solutions of the slowly rotating K-N black hole with different boundary conditions are analysed. We find stable solutions and instantons under certain boundary conditions.

  9. Expression of canonical WNT/β-CATENIN signaling components in the developing human lung

    Directory of Open Access Journals (Sweden)

    Zhang Mingfeng

    2012-07-01

    Full Text Available Abstract Background The WNT/β-CATENIN signaling cascade is crucial for the patterning of the early lung morphogenesis in mice, but its role in the developing human lung remains to be determined. In this study, expression patterns of canonical WNT/β-CATENIN signaling components, including WNT ligands (WNT2, WNT7B, receptors ( FZD4, FZD7, LRP5, LRP6, transducers ( DVL2, DVL3, GSK-3β, β-CATENIN, APC, AXIN2, transcription factors ( TCF4, LEF1 and antagonists ( SOSTDC1 were examined in human embryonic lung at 7, 12, 17 and 21 weeks of gestation (W by real-time qRT-PCR and in situ hybridization. Results qRT-PCR analysis showed that some of these components were gradually upregulated, while some were significantly downregulated from the 7 W to the 12 W. However, most components reached a high level at 17 W, with a subsequent decrease at 21 W. In situ hybridization showed that the canonical WNT ligands and receptors were predominantly located in the peripheral epithelium, whereas the canonical WNT signal transducers and transcription factors were not only detected in the respiratory epithelium, but some were also scattered at low levels in the surrounding mesenchyme in the developing human lung. Furthermore, Western blot, qRT-PCR and histological analysis demonstrated that the β-CATENIN-dependent WNT signaling in embryonic human lung was activated in vitro by CHIR 99021 stimulation. Conclusions This study of the expression patterns and in vitro activity of the canonical WNT/β-CATENIN pathways suggests that these components play an essential role in regulation of human lung development.

  10. Non-adiabatic molecular Hamiltonian: Canonical transformation coupling electronic and vibrational motions

    OpenAIRE

    Hubac, Ivan; Babinec, Peter; Polasek, Martin; Urban, Jan; Mach, Pavel; Masik, Jozef; Leszczynski, Jerzy

    1998-01-01

    The coupling of electronic and vibrational motion is studied by two canonical transformations namely normal coordinate transformation and momentum transformation on molecular Hamiltonian. It is shown that by these transformations we can pass from crude approximation to adiabatic approximation and then to non-adiabatic (diabatic) Hamiltonian. This leads to renormalized fermions and renormalized diabatic phonons. Simple calculations on $H_{2}$, $HD$, and $D_{2}$ systems are performed and compar...

  11. Analytical functions in non-canonical two dimensional algebras; Funzioni analitiche nelle algebre a due componenti

    Energy Technology Data Exchange (ETDEWEB)

    Catoni, Francesco; Zampetti, Paolo [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dipt. Energia; Cannata, Roberto [ENEA, Centro Ricerche Casaccia, Rome (Italy). Funzione Centrale INFO; Nichelatti, Enrico [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dipt. Innovazione

    1997-10-01

    Systems of two-dimensional hypercomplex numbers are usually studied in their canonical form, i.e. according to the multiplicative rule for the ``imaginary``versor i{sup 2} = {+-} 1, 0. In this report those systems for which i{sup 2} = {alpha} + {beta}i are studied and expressions are derived for functions given by series expansion as well as for some elementary functions. The results obtained for systems which can be decomposed are then extended to all systems.

  12. Canonical formalism of action-at-a-distance electrodynamics and many-particle potential among charged particles

    Science.gov (United States)

    Ohta, Tadayuki; Kimura, Toshiei

    1993-10-01

    The second post-Coulombian Lagrangian of Wheeler-Feynman electrodynamics for a many-particle system is treated according to a canonical formalism of a singular Lagrangian with higher derivatives. The canonical equations are given in terms of a reduced Hamiltonian with Dirac brackets, but they are transformed to be expressed in terms of ordinary Poisson brackets by redefinition of canonical variables. The reduced Hamiltonian includes a characteristic form of three-particle and four-particle potentials. Finally a direct pathway to the reduced Hamiltonian is presented via first-order formalism of the Maxwell theory with charged particles.

  13. Canonical Transformations and Loop Formulation of SU(N) Lattice Gauge Theories

    CERN Document Server

    Mathur, Manu

    2015-01-01

    We construct canonical transformations to reformulate SU(N) Kogut-Susskind lattice gauge theory in terms of a set of fundamental loop & string flux operators along with their canonically conjugate loop & string electric fields. We show that as a consequence of SU(N) Gauss laws all SU(N) string degrees of freedom become cyclic and decouple from the physical Hilbert space ${\\cal H}^p$. The canonical relations between the initial SU(N) link operators and the final SU(N) loop & string operators over the entire lattice are worked out in a self consistent manner. The Kogut-Susskind Hamiltonian rewritten in terms of the fundamental physical loop operators has global SU(N) invariance. There are no gauge fields. We further show that the $(1/g^2)$ magnetic field terms on plaquettes create and annihilate the fundamental plaquette loop fluxes while the $(g^2)$ electric field terms describe all their interactions. In the weak coupling ($g^2 \\rightarrow 0$) continuum limit the SU(N) loop dynamics is described b...

  14. Thermodynamic signatures of an underlying quantum phase transition: A grand canonical approach

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez, Kevin, E-mail: kfjimenezfals@gmail.com; Reslen, Jose, E-mail: reslenjo@yahoo.com

    2016-08-06

    Highlights: • The grand-canonical statistics of a quantum phase transition is studied. • Thermodynamic quantities display features related to the quantum phase transition. • A mean field approach allows to obtain the partition function analytically. - Abstract: The grand canonical formalism is employed to study the thermodynamic structure of a model displaying a quantum phase transition when studied with respect to the canonical formalism. A numerical survey shows that the grand partition function diverges following a power law when the interaction parameter approaches a limiting constant. The power-law exponent takes a distinctive value when such limiting constant coincides with the critical point of the subjacent quantum phase transition. An approximated expression for the grand partition function is derived analytically implementing a mean field scheme and a number of thermodynamic observables are obtained. The system observables show signatures that can be used to track the critical point of the underlying transition. This result provides a simple fact that can be exploited to verify the existence of a quantum phase transition avoiding the zero temperature regime.

  15. Canonical correlation between LFP network and spike network during working memory task in rat.

    Science.gov (United States)

    Yi, Hu; Zhang, Xiaofan; Bai, Wenwen; Liu, Tiaotiao; Tian, Xin

    2015-08-01

    Working memory refers to a system to temporary holding and manipulation of information. Previous studies suggested that local field potentials (LFPs) and spikes as well as their coordination provide potential mechanism of working memory. Popular methods for LFP-spike coordination only focus on the two modality signals, isolating each channel from multi-channel data, ignoring the entirety of the networked brain. Therefore, we investigated the coordination between the LFP network and spike network to achieve a better understanding of working memory. Multi-channel LFPs and spikes were simultaneously recorded in rat prefrontal cortex via microelectrode array during a Y-maze working memory task. Functional connectivity in the LFP network and spike network was respectively estimated by the directed transfer function (DTF) and maximum likelihood estimation (MLE). Then the coordination between the two networks was quantified via canonical correlation analysis (CCA). The results show that the canonical correlation (CC) varied during the working memory task. The CC-curve peaked before the choice point, describing the coordination between LFP network and spike network enhanced greatly. The CC value in working memory showed a significant higher level than inter-trial interval. Our results indicate that the enhanced canonical correlation between the LFP network and spike network may provide a potential network integration mechanism for working memory.

  16. Intra-epithelial requirement of canonical Wnt signaling for tooth morphogenesis.

    Science.gov (United States)

    Zhu, XiaoJing; Zhao, Pan; Liu, YuDong; Zhang, XiaoYun; Fu, Jiang; Ivy Yu, H-M; Qiu, Mengsheng; Chen, YiPing; Hsu, Wei; Zhang, Zunyi

    2013-04-26

    Multiple Wnt ligands are expressed in the developing tooth and play important and redundant functions during odontogenesis. However, the source of Wnt ligands and their targeting cells and action mechanism in tooth organogenesis remain largely elusive. Here we show that epithelial inactivation of Gpr177, the mouse Wntless (Wls) whose product regulates Wnt sorting and secretion, leads to arrest of tooth development at the early cap stage and abrogates tooth-forming capability of the dental epithelium. Gpr177 in the epithelium is necessary for the activation of canonical Wnt signaling in the dental epithelium and formation of a functional enamel knot. Epithelial deletion of Gpr177 results in defective gene expression and cellular behavior in the dental epithelium but does not alter odontogenic program in the mesenchyme. Furthermore, deletion of Axin2, a negative intracellular regulator of canonical Wnt signaling, rescues the tooth defects in mice carrying Gpr177 mutation in the dental epithelium. Together with the fact that active Wnt canonical signaling is present predominantly in the dental epithelium during tooth development, our results demonstrate that Gpr177-mediated Wnt ligands in the dental epithelium act primarily in an intra-epithelial context to regulate enamel knot formation and subsequent tooth development.

  17. Canonical Correlation between the Leaf Quality Indicators of "Moderate Aroma" Flue-cured Tobacco

    Institute of Scientific and Technical Information of China (English)

    Lin; MENG; Yuangang; DAI; Chengdong; WANG; Shusheng; WANG; Wenjing; SONG; Yuanhua; WU; Yimin; XU

    2015-01-01

    In order to find out the correlation between tobacco quality evaluation indicators in China’s traditional " moderate aroma" tobaccoproducing areas and simplify the tobacco quality evaluation indicators,we evaluate the appearance quality and smoking quality of 143 flue-cured tobacco leaf samples in China’s " moderate aroma" tobacco-producing areas,test the physical traits and chemical component,and analyze the canonical correlation between four quality evaluation indicators. The results show that there is significant or extremely significant canonical correlation between four evaluation indicators( tobacco smoking quality,chemical component,appearance quality and physical trait quality); the cumulative variance contribution rate of evaluation indicators is in the order of chemical component( 69. 17%) > appearance quality( 68. 76%) > physical traits( 64. 13%); appearance quality is most closely related to physical traits( 93. 84%). The individual indicators for tobacco quality evaluation make different contribution to the correlation between quality evaluation indicators. The chemical component evaluation indicators mainly include total sugar and ratio of total sugar to betaine; sensory taste indicators mainly include aroma volume,smoke concentration,irritation and softness degree; physical trait evaluation indicators mainly include leaf weight,leaf length and leaf density; appearance quality indicators mainly include leaf organizational structure,color,maturity and identity. Studies have shown that in the large-scale ecoregion,using canonical correlation analysis to simplify tobacco quality evaluation indicators is feasible.

  18. Canonical Formalism for a 2n-Dimensional Model with Topological Mass Generation

    CERN Document Server

    Deguchi, Shinichi

    2008-01-01

    The 4-dimensional model with topological mass generation that was found by Dvali, Jackiw and Pi has recently been generalized to any even number of dimensions (2n-dimensions) in a nontrivial manner in which a Stueckelberg-type mass term is introduced [S. Deguchi and S. Hayakawa, Phys. Rev. D77, 045003 (2008), arXiv:0711.1446]. The present paper deals with a self-contained model, called here modified hybrid model, proposed in this 2n-dimensional generalization and considers the canonical formalism for this model. For the sake of convenience, the canonical formalism itself is studied for a model equivalent to the modified hybrid model by following the recipe for treating constrained Hamiltonian systems. This formalism is applied to the canonical quantization of the equivalent model in order to clarify observable and unobservable particles in the model. The equivalent model (with a gauge-fixing term) is converted to the modified hybrid model (with a corresponding gauge-fixing term) in a BRST-invariant manner. Th...

  19. Canonical transformations relating the oscillator and Coulomb problems and their relevance for collective motions

    Energy Technology Data Exchange (ETDEWEB)

    Moshinsky, M.; Seligman, T.H.

    1981-08-01

    The present paper can be viewed from two standpoints. The first is that it derives the canonical transformation that takes the Hamiltonian of the Coulomb problem (in the Fock--Bargmann formulation) into that of the harmonic oscillator, while transforming the angular momenta of both problems into each other. The second is the one in which the solution of the previous problem is required if we wish to find the canonical transformation relating microscopic and macroscopic collective models, where the former is derived from a system of A particles moving in two dimensions and interacting through harmonic oscillator forces. The canonical transformation shows the existence of a U(3) symmetry group in the microscopic collective model corresponding to that of the three-dimensional oscillator which is the Hamiltonian of the macroscopic collective model. The importance of this result rests on the fact that had the motion of the particles taken place in the physical three-dimensional space, rather than the hypothetical two-dimensional one discussed here, the symmetry group would have been U(6) rather than U(3). Thus, the group theoretical structure of an s-d boson picture or, equivalently, of a generalized Bohr--Mottelson approach, is present implicitly in an A-body system interacting through harmonic oscillator forces.

  20. Structure of multiphoton quantum optics. II. Bipartite systems, physical processes, and heterodyne squeezed states

    CERN Document Server

    Dell'Anno, F; Illuminati, F; Anno, Fabio Dell'; Siena, Silvio De; Illuminati, Fabrizio

    2004-01-01

    Extending the scheme developed for a single mode of the electromagnetic field in the preceding paper ``Structure of multiphoton quantum optics. I. Canonical formalism and homodyne squeezed states'', we introduce two-mode nonlinear canonical transformations depending on two heterodyne mixing angles. They are defined in terms of hermitian nonlinear functions that realize heterodyne superpositions of conjugate quadratures of bipartite systems. The canonical transformations diagonalize a class of Hamiltonians describing non degenerate and degenerate multiphoton processes. We determine the coherent states associated to the canonical transformations, which generalize the non degenerate two--photon squeezed states. Such heterodyne multiphoton squeezed are defined as the simultaneous eigenstates of the transformed, coupled annihilation operators. They are generated by nonlinear unitary evolutions acting on two-mode squeezed states. They are non Gaussian, highly non classical, entangled states. For a quadratic nonline...