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Sample records for candidate younger dryas

  1. Cometary airbursts and atmospheric chemistry: Tunguska and a candidate Younger Dryas event

    CERN Document Server

    Melott, Adrian L; Dreschhoff, Gisela; Johnson, Carey K

    2009-01-01

    We estimate atmospheric chemistry changes from ionization at the 1908 Tunguska airburst event, finding agreement with nitrate enhancement in GIS2PH and GISP2 ice cores and noting an unexplained accompanying ammonium spike. We then consider the candidate Younger Dryas comet impact. The estimated NOx production and O3 depletion are large, beyond accurate extrapolation. A modest nitrate deposition signal exists in ice core data. The predicted very large impulsive deposition might be visible in higher resolution data. Ammonium has been attributed to biomass burning, and found coincident with nitrate spikes at YD onset in both the GRIP and GISP2 ice cores. A similar result is well-resolved in Tunguska ice core data, but the Tunguska forest fire was far too small to account for this. Direct input of ammonia from a comet into the atmosphere is consistent with the spike for the candidate YD object, but also inadequate for Tunguska. An analog of the Haber process with hydrogen contributed by the cometary or surface wa...

  2. The atmosphere during the younger dryas.

    Science.gov (United States)

    Mayewski, P A; Meeker, L D; Whitlow, S; Twickler, M S; Morrison, M C; Alley, R B; Bloomfield, P; Taylor, K

    1993-07-09

    One of the most dramatic climate change events observed in marine and ice core records is the Younger Dryas, a return to near-glacial conditions that punctuated the last deglaciation. High-resolution, continuous glaciochemical records, newly retrieved from central Greenland, record the chemical composition of the arctic atmosphere at this time. This record shows that both the onset and the termination of the Younger Dryas occurred within 10 to 20 years and that massive, frequent, and short-term (decadal or less) changes in atmospheric composition occurred throughout this event. Changes in atmospheric composition are attributable to changes in the size of the polar atmospheric cell and resultant changes in source regions and to the growth and decay of continental biogenic source regions.

  3. PALEOCLIMATE: The Younger Dryas: Cold, Cold Everywhere?

    Science.gov (United States)

    Rodbell, D T

    2000-10-13

    The transition from the last ice age to the current warm period was interupted by a ~1000-year return to glacial conditions. Most of the evidence for this Younger Dryas (YD) event comes from in and around the North Atlantic, and the geographical extent of the event remains uncertain. In his Perspective, Rodbell reviews the evidence for and against a YD event in the Southern Hemisphere and highlights the study by Bennett et al., who have found no evidence for a YD event in four lake records from southern Chile.

  4. Meltwater routing and the Younger Dryas.

    Science.gov (United States)

    Condron, Alan; Winsor, Peter

    2012-12-04

    The Younger Dryas--the last major cold episode on Earth--is generally considered to have been triggered by a meltwater flood into the North Atlantic. The prevailing hypothesis, proposed by Broecker et al. [1989 Nature 341:318-321] more than two decades ago, suggests that an abrupt rerouting of Lake Agassiz overflow through the Great Lakes and St. Lawrence Valley inhibited deep water formation in the subpolar North Atlantic and weakened the strength of the Atlantic Meridional Overturning Circulation (AMOC). More recently, Tarasov and Peltier [2005 Nature 435:662-665] showed that meltwater could have discharged into the Arctic Ocean via the Mackenzie Valley ~4,000 km northwest of the St. Lawrence outlet. Here we use a sophisticated, high-resolution, ocean sea-ice model to study the delivery of meltwater from the two drainage outlets to the deep water formation regions in the North Atlantic. Unlike the hypothesis of Broecker et al., freshwater from the St. Lawrence Valley advects into the subtropical gyre ~3,000 km south of the North Atlantic deep water formation regions and weakens the AMOC by 30%. We conclude that meltwater discharge from the Arctic, rather than the St. Lawrence Valley, was more likely to have triggered the Younger Dryas cooling.

  5. Analysis of the Younger Dryas Impact Layer

    Energy Technology Data Exchange (ETDEWEB)

    Firestone, Richard B.; West, Allen; Revay, Zsolt; Hagstrum, Jonathon T,; Belgya, Thomas; Hee, Shane S. Que; Smith, Alan R.

    2010-02-27

    We have uncovered a thin layer of magnetic grains and microspherules, carbon spherules, and glass-like carbon at nine sites across North America, a site in Belgium, and throughout the rims of 16 Carolina Bays. It is consistent with the ejecta layer from an impact event and has been dated to 12.9 ka BP coinciding with the onset of Younger Dryas (YD) cooling and widespread megafaunal extinctions in North America. At many locations the impact layer is directly below a black mat marking the sudden disappearance of the megafauna and Clovis people. The distribution pattern of the Younger Dryas boundary (YDB) ejecta layer is consistent with an impact near the Great Lakes that deposited terrestrial-like ejecta near the impact site and unusual, titanium-rich projectile-like ejecta further away. High water content associated with the ejecta, up to 28 at. percent hydrogen (H), suggests the impact occurred over the Laurentide Ice Sheet. YDB microspherules and magnetic grains are highly enriched in TiO{sub 2}. Magnetic grains from several sites are enriched in iridium (Ir), up to 117 ppb. The TiO{sub 2}/FeO, K/Th, TiO{sub 2}/Zr, Al{sub 2}O{sub 3}/FeO+MgO, CaO/Al{sub 2}O{sub 3}, REE/ chondrite, FeO/MnO ratios and SiO{sub 2}, Na{sub 2}O, K{sub 2}O, Cr{sub 2}O{sub 3}, Ni, Co, U, Th and other trace element abundances are inconsistent with all terrestrial and extraterrestrial (ET) sources except for KREEP, a lunar igneous rock rich in potassium (K), rare-earth elements (REE), phosphorus (P), and other incompatible elements including U and Th. Normal Fe, Ti, and {sup 238}U/{sup 235}U isotopic abundances were found in the magnetic grains, but {sup 234}U was enriched over equilibrium values by 50 percent in Murray Springs and by 130 percent in Belgium. 40K abundance is enriched by up to 100 percent in YDB sediments and Clovis chert artifacts. Highly vesicular carbon spherules containing nanodiamonds, glass-like carbon, charcoal and soot found in large quantities in the YDB layer are

  6. Younger Dryas glaciers in the High Atlas, Morocco

    Science.gov (United States)

    Hughes, Philip; Fink, David

    2016-04-01

    Twelve cirque glaciers formed during the Younger Dryas on the mountains of Aksoual (3912 m a.s.l.) and Adrar el Hajj (3129 m a.s.l.) in the Marrakesh High Atlas. Moraines in two separate cirques on these mountains have been dated using 10Be and 36Cl exposure dating. In both cirques the age scatter is relatively small (13.8-10.1 ka) and all ages overlap within error with the Younger Dryas (12.9-11.7 ka). The glaciers were small and covered ELAs) ranging from 2470 and 3560 m. This large range is attributed to local topoclimatic factors with the lowest glacier (confirmed as Younger Dryas in age by 3 exposure ages) occupying a very steep cirque floor where a combination of steep glacier gradient and a large potential avalanche catchment enabled its low-lying position. This indicates that caution should be taken when using single glacier sites for reconstructing regional palaeoclimate, especially those formed in steep catchments that have strong topoclimatic controls. The average ELA of the twelve Younger Dryas glaciers was c. 3109 m a.s.l. (St Dev = 325 m) and this represents an ELA depression of > 1000 m from the modern theoretical regional ELA. Under precipitation values similar to today this would require a mean annual temperature depression of 9°C. Moreover, the glacier-climate modelling indicates that it is very unlikely that climate was drier than today during the Younger Dryas in the Marrakesh High Atlas.

  7. Glacier retreat in New Zealand during the Younger Dryas stadial.

    Science.gov (United States)

    Kaplan, Michael R; Schaefer, Joerg M; Denton, George H; Barrell, David J A; Chinn, Trevor J H; Putnam, Aaron E; Andersen, Bjørn G; Finkel, Robert C; Schwartz, Roseanne; Doughty, Alice M

    2010-09-09

    Millennial-scale cold reversals in the high latitudes of both hemispheres interrupted the last transition from full glacial to interglacial climate conditions. The presence of the Younger Dryas stadial (approximately 12.9 to approximately 11.7 kyr ago) is established throughout much of the Northern Hemisphere, but the global timing, nature and extent of the event are not well established. Evidence in mid to low latitudes of the Southern Hemisphere, in particular, has remained perplexing. The debate has in part focused on the behaviour of mountain glaciers in New Zealand, where previous research has found equivocal evidence for the precise timing of increased or reduced ice extent. The interhemispheric behaviour of the climate system during the Younger Dryas thus remains an open question, fundamentally limiting our ability to formulate realistic models of global climate dynamics for this time period. Here we show that New Zealand's glaciers retreated after approximately 13 kyr bp, at the onset of the Younger Dryas, and in general over the subsequent approximately 1.5-kyr period. Our evidence is based on detailed landform mapping, a high-precision (10)Be chronology and reconstruction of former ice extents and snow lines from well-preserved cirque moraines. Our late-glacial glacier chronology matches climatic trends in Antarctica, Southern Ocean behaviour and variations in atmospheric CO(2). The evidence points to a distinct warming of the southern mid-latitude atmosphere during the Younger Dryas and a close coupling between New Zealand's cryosphere and southern high-latitude climate. These findings support the hypothesis that extensive winter sea ice and curtailed meridional ocean overturning in the North Atlantic led to a strong interhemispheric thermal gradient during late-glacial times, in turn leading to increased upwelling and CO(2) release from the Southern Ocean, thereby triggering Southern Hemisphere warming during the northern Younger Dryas.

  8. Atlantic Warm Pool Trigger for the Younger Dryas Climate Event

    Science.gov (United States)

    Abdul, N. A.; Mortlock, R. A.; Wright, J. D.; Fairbanks, R. G.; Teneva, L. T.

    2011-12-01

    There is growing evidence that variability in the size and heat content of the tropical Atlantic Warm Pool impacts circum-North Atlantic climate via the Atlantic Multi-decadal Oscillation mode (Wang et al., 2008). The Atlantic Warm Pool spans the Gulf of Mexico, Caribbean Sea and the western tropical North Atlantic. Barbados is located near the center of the tropical Atlantic Warm Pool and coupled ocean models suggest that Barbados remains near the center of the tropical Atlantic Warm Pool under varying wind stress simulations. Measurements of the oxygen isotope paleothermometer in Acropora palmata coral species recovered from cores offshore Barbados, show a 3oC monotonic decrease in sea surface temperature from 13106 ± 83 to 12744 ± 61 years before present (errors given as 2 sigma). This interval corresponds to a sea level rise from 71.4 meters to 67.1 meters below present levels at Barbados. The 3oC temperature decrease is captured in eight A. palmata specimens that are in stratigraphic sequence, 230Th/234U dated, and analyzed for oxygen isotopes. All measurements are replicated. We are confident that this is the warm pool equivalent of the Younger Dryas climate event. The initiation of this temperature drop in the Atlantic Warm Pool predates the Younger Dryas start in Greenland ice cores, reported to start at 12896 ± 138 years (relative to AD 2000) (Rasmussen et al., 2006), while few other Younger Dryas climate records are dated with similar accuracy to make the comparison. Rasmussen, S.O., Andersen, K.K., Svensson, A.M., Steffensen, J.P., Vinther, B.M., Clausen, H.B., Siggaard-Andersen, M.L., Johnsen, S.J., Larsen, L.B., Dahl-Jensen, D., Bigler, M., Röthlisberger, R., Fischer, H., Goto-Azuma, K., Hansson, M.E., and Ruth, U., 2006, A new Greenland ice core chronology for the last glacial termination: J. Geophys. Res., v. 111, p. D06102. Wang, C., Lee, S.-K., and Enfield, D.B., 2008, Atlantic Warm Pool acting as a link between Atlantic Multidecadal

  9. Glacier-derived climate for the Younger Dryas in Europe

    Science.gov (United States)

    Pellitero, Ramon; Rea, Brice R.; Spagnolo, Matteo; Hughes, Philip; Braithwaite, Roger; Renssen, Hans; Ivy-Ochs, Susan; Ribolini, Adriano; Bakke, Jostein; Lukas, Sven

    2016-04-01

    We have reconstructed and calculated the glacier equilibrium line altitudes (ELA) for 120 Younger Dryas palaeoglaciers from Morocco in the south to Svalbard in the north and from Ireland in the west to Turkey in the east. The chronology of these landform were checked and, when derived from cosmogenic dates, these were recalculated based on newer production rates. Frontal moraines/limits for the palaeoglaciers were used to reconstruct palaeoglacier extent by using a GIS tool which implements a discretised solution for the assumption of perfect-plasticity ice rheology for a single flowline and extents this out to a 3D ice surface. From the resulting equilibrium profile, palaeoglaciers palaeo-ELAs were calculated using another GIS tool. Where several glaciers were reconstructed in a region, a single ELA value was generated following the methodology of Osmaston (2005). In order to utilise these ELAs for quantitative palaeo-precipitation reconstructions an independent regional temperature analysis was undertaken. A database of 121 sites was compiled where the temperature was determined from palaeoproxies other than glaciers (e.g. pollen, diatoms, choleoptera, chironimids…) in both terrestrial and offshore environments. These proxy data provides estimates of average annual, summer and winter temperatures. These data were merged and interpolated to generate maps of average temperature for the warmest and coldest months and annual average temperature. From these maps the temperature at the ELA was obtained using a lapse rate of 0.65°C/100m. Using the ELA temperature range and summer maximum in a degree-day model allows determination of the potential melt which can be taken as equivalent to precipitation given the assumption a glacier is in equilibrium with climate. Results show that during the coldest part of the Younger Dryas precipitation was high in the British Isles, the NW of the Iberian Peninsula and the Vosges. There is a general trend for declining precipitation

  10. Warm summers during Younger Dryas cold reversal over Eurasia

    Science.gov (United States)

    Schenk, Frederik; Muschitiello, Francesco; Heikkilä, Miaja; Väliranta, Minna; Tarasov, Lev; Brandefelt, Jenny; Johansson, Arne; Näslund, Jens-Ove; Wohlfarth, Barbara

    2016-04-01

    The Younger Dryas cold reversal (GS-1) sticks out as a major stadial interrupting the mid to late deglaciation with a sharp temperature drop of several degrees around the North Atlantic with global teleconnections. The abrupt return to a very cold glacial-like ocean state introduces a strong temperature anomaly to the climate system contrasting the high solar radiation received by northern summers. Here we show that, in contrast to earlier coarse resolution climate simulations of the Younger Dryas, these competing factors result in rather warm summer conditions over Eurasia comparable to the preceding warm period of the late Allerød (GI-1a). Despite up to 10 K colder sea-surface-temperatures in summer, our high resolution simulation with the Community Earth System Model 1 (CESM1.0.5) suggests that the presence of large ice sheets over Scandinavia, Spitsbergen and the Kara Sea significantly modifies atmospheric flow in summer preventing cold westerly winds from the Atlantic to impact the continent. Instead, fluid dynamics around ice sheets deflect winds to the north or south along the coasts supported by divergent flow from ice domes, stratification and increased tendency to high pressure and atmospheric blocking. Consistent with our model simulation, we show that temperature reconstructions derived from an extended compilation of multi-proxy lake records (chironomids, aquatic pollen, macrofossils) suggest warm July conditions of 13-17° C for continental Europe with exception of coastal and high elevation sites. The analysis of simulated growing degree days, season length and first results from paleo lake modelling driven by climate model output suggests that severe winter to spring conditions significantly delay and shorten the vegetation season but do not produce cold summers as previously simulated.

  11. North Atlantic Storm Activity During the Younger Dryas

    Science.gov (United States)

    Toomey, M.

    2015-12-01

    The risks posed to cities along the Eastern Seaboard by a potential intensification of tropical cyclone activity over the coming decades remain poorly constrained, in part, due to a lack of available storm proxy records that extend beyond the relatively stable climates of the late Holocene. Previous work in the Bahamas shows that coarse-grained, high-energy event layers in carbonate bank margin sediments: (1) closely track recent historic hurricane events and (2) that the sensitivity of this proxy may be less affected by the deglacial changes in sea level that have limited our ability to reconstruct past hurricane activity using overwash records from back-barrier beach settings. Here we present a record of storm triggered turbidite deposition from a suite of well dated (e.g. Lynch-Stieglitz et al., 2011, Paleoceanography) jumbo piston cores taken offbank (300-500 mbsl) the Dry Tortugas, Florida, that spans abrupt transitions in North Atlantic sea surface temperature and thermohaline circulation during the Younger Dryas (12.9 - 11.5 kyr BP). This record, along with General Circulation Model output (TraCE: NCAR-CGD), indicates strong hurricane activity may have occurred along Southeastern US coasts through this interval despite considerably colder North Atlantic SSTs.

  12. The Younger Dryas in the West Pacific marginal seas

    Institute of Scientific and Technical Information of China (English)

    汪品先; 卞云华; 李保华; 黄奇瑜

    1996-01-01

    The occurrence and nature of the Younger Dryas (YD) abrupt climatic event in the West Pacific marginal seas are discussed on the basis of 15 sediment cores. This event has been found in all these cores studied with a high-resolution stratigraphy and proved to be common to the West Pacific region. As shown by the isotopic and micropaleontologic analyses, the YD, dated by C-14 at about 11000 to 10000 a B.P., is a brief event of sea surface cooling in winter season following a fresh-water pulse about 12000 a B.P. The "apparent regression" of the YD recorded in the Changjiang River delta and the Sea of Japan agrees with the interpretation that the YD is a period of slowed sea level rising between two phases of rapid rising. Both the winter surface water cooling and the increasing salinity in the YD imply a strengthening of the winter, but not summer monsoon circulation. This major climatic event in the marginal seas must have had profound impact on the adjacent continent.

  13. Heinrich 0 at the Younger Dryas Termination Offshore Newfoundland

    Science.gov (United States)

    Pearce, C.; Andrews, J. T.; Jennings, A. E.; Bouloubassi, I.; Seidenkrantz, M. S.; Kuijpers, A.; Hillaire-Marcel, C.

    2014-12-01

    The last deglaciation was marked by intervals of rapid climatic fluctuations accompanied by glacial advances and retreats along the eastern edge of the Laurentide ice sheet. The most severe of these events, the Younger Dryas cold reversal, was accompanied by the major detrital carbonate (DC) event generally referred to as "Heinrich event 0" (H0) in the westernmost and southern Labrador Sea. A detrital carbonate layer was observed in a high resolution marine sediment record from southern Newfoundland and the onset of the event was dated to 11,600 ± 70 cal. yrs. BP (local ΔR = 140 yrs.). A variety of different proxies was applied to investigate the transport mechanisms for deposition of the layer and provenance of the carbonates. Elevated concentrations of dolomite and calcite based on quantitative X-ray diffraction measurements, combined with the presence of several mature petrogenic biomarkers limit the source of the H0 detrital input to Palaeozoic carbonate outcrops in north-eastern Canada. The event is attributed to the rapid ice retreat from the Hudson Strait directly following the warming at the onset of the Holocene. Based on additional proxy data published earlier from the same record, the event succeeded the early Holocene resumption of the Atlantic Meridional Overturning Circulation (AMOC), indicating that the Hudson Strait meltwater event had probably no significant impact on the AMOC. The detrital carbonate layer can be found in other marine sediment records along the Labrador Current pathway, from Hudson Strait to the Grand Banks and the southern Newfoundland slope. By using the onset of deposition of the carbonates as a time-synchronous marker, the DC layer has great potential for improving marine chronologies of late glacial age in the region and evaluating spatial variations in ΔR values.

  14. Subtropical freshwater event at the onset of Younger Dryas

    Science.gov (United States)

    Weinelt, M.; Repschläger, J.; Balmer, S.; Schwab, C.; Andersen, N.; Blanz, T.; Sarnthein, M.

    2012-12-01

    The Younger Dryas (YD) (12.79-11.6 ka BP) cold spell during the last deglaciation is associated with a major breakdown of the Atlantic meridional overturning circulation (AMOC), the details of which are still controversial. Catastrophic events like a bolide impact or a major outflow of meltwater stored in the proglacial Lake Agassiz, which led to the capping of North Atlantic deep water convection sites, have been suggested to trigger the AMOC shutdown. However the geomorphological evidence for such a meltwater flood is not in agreement with the timing of the YD. Also, the YD was postulated to be part of a deglacial sequence of events generally characteristic of glacial terminations involving the displacement of major climatic zones and oceanographic fronts. We present detailed paleoceanographic records from sediment cores MD08-3180/ GEOFAR KF16 (38°N; 31.13°W, 3050 m w.d.) retrieved immediately east of the Mid Atlantic ridge south of the Azores Islands. At present, this site is located at the northern rim of the Azores Current, which delineates the subtropical gyre, recirculating warm waters of the North Atlantic Current. Due to its position at the boundary between temperate North East Atlantic waters and subtropical gyre waters, the site is ideally suited to trace past changes in the alternating influence of both water masses. Parallel stable-oxygen isotope records of surface water dwelling foraminifera Globigerinoides ruber w. (habitat depth 0-25m) and Globigerina bulloides (habitat depth 0-300m) may document the structure of surface waters. Sea Surface Temperatures (SST) were derived from the UK'37 index and from planktonic foraminifera (PF) assemblages using transfer functions. d18Ow-ice and Sea Surface Salinities were estimated using the d18O G.ruber w. record corrected for SST and changes in global ice volume. The d18O records of G.ruber w. and G.bulloides diverge between 13.4 ka and 12.95 ka BP. d18Ow data show a gradual increase in the freshening of

  15. Enhanced sea-ice export from the Arctic during the Younger Dryas.

    Science.gov (United States)

    Not, Christelle; Hillaire-Marcel, Claude

    2012-01-31

    The Younger Dryas cold spell of the last deglaciation and related slowing of the Atlantic meridional overturning circulation have been linked to a large array of processes, notably an influx of fresh water into the North Atlantic related to partial drainage of glacial Lake Agassiz. Here we observe a major drainage event, in marine sediment cores raised from the Lomonosov Ridge, in the central Arctic Ocean marked by a pulse in detrital dolomitic-limestones. This points to an Arctic-Canadian sediment source area with about fivefold higher Younger Dryas ice-rafting deposition rate, in comparison with the Holocene. Our findings thus support the hypothesis of a glacial drainage event in the Canadian Arctic area, at the onset of the Younger Dryas, enhancing sea-ice production and drifting through the Arctic, then export through Fram Strait, towards Atlantic meridional overturning circulation sites of the northern North Atlantic.

  16. Gradual onset and recovery of the Younger Dryas abrupt climate event in the tropics.

    Science.gov (United States)

    Partin, J W; Quinn, T M; Shen, C-C; Okumura, Y; Cardenas, M B; Siringan, F P; Banner, J L; Lin, K; Hu, H-M; Taylor, F W

    2015-01-01

    Proxy records of temperature from the Atlantic clearly show that the Younger Dryas was an abrupt climate change event during the last deglaciation, but records of hydroclimate are underutilized in defining the event. Here we combine a new hydroclimate record from Palawan, Philippines, in the tropical Pacific, with previously published records to highlight a difference between hydroclimate and temperature responses to the Younger Dryas. Although the onset and termination are synchronous across the records, tropical hydroclimate changes are more gradual (>100 years) than the abrupt (10-100 years) temperature changes in the northern Atlantic Ocean. The abrupt recovery of Greenland temperatures likely reflects changes in regional sea ice extent. Proxy data and transient climate model simulations support the hypothesis that freshwater forced a reduction in the Atlantic meridional overturning circulation, thereby causing the Younger Dryas. However, changes in ocean overturning may not produce the same effects globally as in Greenland.

  17. Nanodiamonds and wildfire evidence in the Usselo horizon postdate the Allerød-Younger Dryas boundary

    NARCIS (Netherlands)

    Van Hoesel, Annelies; Hoek, Wim Z.; Braadbaart, Freek; Van Der Plicht, Johannes; Pennock, Gillian M.; Drury, Martyn R.

    2012-01-01

    The controversial Younger Dryas impact hypothesis suggests that at the onset of the Younger Dryas an extraterrestrial impact over North America caused a global catastrophe. The main evidence for this impact - after the other markers proved to be neither reproducible nor consistent with an impact - i

  18. Reduced solar activity as a trigger for the start of the Younger Dryas?

    NARCIS (Netherlands)

    Renssen, H; van Geel, B; van der Plicht, J; Magny, M

    2000-01-01

    It is generally assumed that changes in ocean circulation forced the abrupt climate changes during the Late Pleistocene, including the Younger Dryas event. Recently, however, it was proposed that variations in solar irradiance could have played a much more prominent role in forcing Pleistocene clima

  19. A Younger Dryas plateau icefield in the Monadhliath, Scotland, and implications for regional palaeoclimate

    Science.gov (United States)

    Boston, Clare M.; Lukas, Sven; Carr, Simon J.

    2015-01-01

    A record of Younger Dryas glaciation in Scotland is well established. However, the role of the Monadhliath, a significant plateau area extending over 840 km2 in central Scotland, has never been investigated systematically. We present the first systematic glacial geomorphological mapping across the whole region, which has led to the identification of hitherto-unrecorded glacial and associated landforms. The spatial distribution of these landforms indicates that the last phase of glaciation in the area was that of a local plateau icefield. In addition, a clear morphostratigraphical signature provides a strong indication that the icefield dates to the Younger Dryas (12.9-11.7 ka), which is supported by numerical ages in the southeast of the study area. Based on the geomorphological evidence and 2D glacier surface profile modelling, a 280 km2 icefield is reconstructed. A novel approach is introduced to quantify plateau icefield thickness for equilibrium line altitude (ELA) and palaeoprecipitation calculations, resulting in greater overall data confidence compared to traditional reconstruction methods. The ELA for the whole icefield is calculated to be 714 ± 25 m, whilst the ELAs of individual outlet glaciers range from 560 m in the west to 816 m in the east, demonstrating a significant W-E precipitation gradient across the region during the Younger Dryas. These ELAs compare well with those calculated for Younger Dryas ice masses reconstructed in neighbouring regions and are in good agreement with overall precipitation patterns suggested for Scotland during this time. Whilst the total amount of precipitation calculated from these ELAs is highly dependent on the method used, irrespective of this, the study suggests a more arid Younger Dryas climate in the region compared to the present day.

  20. Identification of Younger Dryas outburst flood path from Lake Agassiz to the Arctic Ocean.

    Science.gov (United States)

    Murton, Julian B; Bateman, Mark D; Dallimore, Scott R; Teller, James T; Yang, Zhirong

    2010-04-01

    The melting Laurentide Ice Sheet discharged thousands of cubic kilometres of fresh water each year into surrounding oceans, at times suppressing the Atlantic meridional overturning circulation and triggering abrupt climate change. Understanding the physical mechanisms leading to events such as the Younger Dryas cold interval requires identification of the paths and timing of the freshwater discharges. Although Broecker et al. hypothesized in 1989 that an outburst from glacial Lake Agassiz triggered the Younger Dryas, specific evidence has so far proved elusive, leading Broecker to conclude in 2006 that "our inability to identify the path taken by the flood is disconcerting". Here we identify the missing flood path-evident from gravels and a regional erosion surface-running through the Mackenzie River system in the Canadian Arctic Coastal Plain. Our modelling of the isostatically adjusted surface in the upstream Fort McMurray region, and a slight revision of the ice margin at this time, allows Lake Agassiz to spill into the Mackenzie drainage basin. From optically stimulated luminescence dating we have determined the approximate age of this Mackenzie River flood into the Arctic Ocean to be shortly after 13,000 years ago, near the start of the Younger Dryas. We attribute to this flood a boulder terrace near Fort McMurray with calibrated radiocarbon dates of over 11,500 years ago. A large flood into the Arctic Ocean at the start of the Younger Dryas leads us to reject the widespread view that Agassiz overflow at this time was solely eastward into the North Atlantic Ocean.

  1. Oxygen Isotopes and Meltwater: Younger Dryas and 8.2 ka Event

    Science.gov (United States)

    Keigwin, L. D.

    2015-12-01

    Delta 18-O is one of our most powerful and widely used proxies, with, arguably, the fewest likely unknown unknowns. Here I will consider the d18-O evidence for the two best-known floods of mostly liquid water to the ocean, the Younger Dryas (YD) and the 8.2 ka event. The first d18-O signal of a meltwater flood in the ocean was reported 40 years ago by Kennett and Shackleton (1975) and that paper led directly to the meltwater diversion hypothesis for the origin of the YD cooling. It was later suggested by Rooth (1982) that such a flood could interrupt Nordic seas convection and trigger the YD cold episode. It was reported at this meeting last year that a candidate flood has been found in the Mackenzie River region of the western Arctic based on low d18-O and multiple other lines of evidence. The 8.2 ka event was about one-tenth the duration of the YD but with possibly higher transport, and is more difficult to detect in open marine sediments. As with the YD, it has been modeled by hosing and low salinities have been derived by temperature correcting the d18-O. The resulting low salinity was shown not to follow the prediction of the highest resolution modeling, and theory, that the fresh water would be transported mostly equatorward along the continental shelf. However, I report here that the low d18-O signal of the 8.2 ka flooding is present in new cores from near Logan Canyon on the Scotian shelf break, and in Jordan Basin, Gulf of Maine. These results substantially validate the modeling of Condron and Winsor that fresh water transport must have been along the continental shelf.

  2. Abrupt release of terrigenous organic carbon to the Laptev Sea at termination of the Younger Dryas

    Science.gov (United States)

    Tesi, T.; Muschitiello, F.; Smittenberg, R.; Jakobsson, M.; Vonk, J.; Hill, P.; Dudarev, O.; Semiletov, I. P.; Kirchner, N.; Noormets, R.; Andersson, A.; Gustafsson, O.

    2015-12-01

    Based on analysis of a piston core collected in 2014 from the Lena River paleo delta, now Laptev Sea, we show that rapid and massive organic carbon (OC) deposition took place into the marine system at the termination of the Younger Dryas when the Arctic region experienced a large and extremely fast climate change. The highly laminated strata with absence of bioturbation further confirm the rapid event-driven emplacement of this deposit which was largely dominated by terrigenous OC as indicated by depleted δ13C values and high concentrations of terrestrial fossil biomarkers (lignin phenols and cutin-derived products). Moreover, the hydrogen isotopic composition (δ2H) of HMW n-alkanes indicates that this terrestrially-derived translocated OC was produced in the watershed during a relatively cold period. The OC appears to be a few thousand years old at time of deposition (ca. 4-5000 radiocarbon years; reservoir age corrected), consistent with the radiocarbon age of pre-aged OC currently supplied by the Lena river. Altogether our results indicate that fast climate warming exerts first-order control on large-scale carbon redistribution. Because the Younger Dryas-Preboreal transition occurred within a few decades, we infer that the abrupt and large release of terrigenous OC was essentially driven by rapid changes in the permafrost stability (i.e., thermal collapse/thawing) and increase in precipitation over the Siberian watershed. Interestingly, only surface and sub-surface carbon pools (i.e., active layer) were remobilized while deep and old sources (radiocarbon dead) did not seem to have substantially contributed to the total land-to-ocean flux during the Younger Dryas-Preboreal transition.

  3. Mountain glacier evolution in the Iberian Peninsula during the Younger Dryas

    Science.gov (United States)

    García-Ruiz, J. M.; Palacios, D.; González-Sampériz, P.; de Andrés, N.; Moreno, A.; Valero-Garcés, B.; Gómez-Villar, A.

    2016-04-01

    We review the evolution of glaciers in the Iberian Mountains during the Younger Dryas (12.9-11.7 ka, following the chronology of Greenland Stadial 1 - GS1) and compare with available environmental and climate data to investigate glacier dynamics during cold stadial episodes. The best examples of Younger Dryas moraines are found in the Central Pyrenees, involving short ice tongues up to 4 km in length in the highest massifs (above 3000 m a.s.l.) of the southern versant. Small cirque glaciers and rock glaciers formed during the YD occurred in other Pyrenean massifs, in the Cantabrian Range and in the Gredos and Guadarrama sierras (Central Range), as indicated by several rocky, polished thresholds that were ice-free at the beginning of the Holocene. Although some former rock glaciers were re-activated during the Younger Dryas, glacial activity was limited in the southernmost part of the Iberian Peninsula (Sierra Nevada). Most Iberian records show vegetation changes during the YD characterized by a forest decline and an expansion of shrubs (mainly Juniperus) and steppe herbs, although the vegetation response was not homogeneous because of variable resilience among ecosystems. Available records also document a variable lake response in terms of hydrology and productivity, with a decrease in sedimentation rates and organic productivity in most high altitude lakes and increases in salinity and relatively lower lake levels at lower altitudes. The impact of the Younger Dryas on the coastal environment was almost negligible, but it was responsible for a brief cessation in sea level rise. High-resolution analyses of new speleothem records have documented a double structure for the YD with an earlier drier phase followed by a relatively more humid period. The review of geomorphological evidence demonstrates a strong latitudinal control of glacial activity during the YD, with more intense development in the northern than in the southern regions. The increase in humidity during

  4. The micromorphology of Younger Dryas-aged black mats from Nevada, Arizona, Texas and New Mexico

    Science.gov (United States)

    Harris-Parks, Erin

    2016-01-01

    Black mats are organic-rich sediments and soils that form in wet environments associated with spring discharge. Micromorphological and geochemical analyses of 25 black mats dating to the Younger Dryas Chronozone (12.9-11.7 ka) and early Holocene were conducted to determine their composition and depositional environment. Samples were collected from Arizona, New Mexico, Texas and Nevada. Micromorphological analyses were conducted on thin sections using polarized and blue fluorescent light. These analyses determined that black mats contain humic acids, fine (5-20 μm) plant fragments, diatoms, phytoliths, and gastropods. The dominant type of organic matter in black mats is derived from herbaceous plants, contradicting previous studies that supported algal or charcoal sources. Differences in the micromorphological characteristics of the samples revealed that black mats formed as three different types, organic horizons, moist soils and, ponded sediments, depending on their topographic position in relation to the water table. The microscopic evidence found in black mats supports the presence of widespread wet environments in Nevada and Arizona during the Younger Dryas Chronozone, clearly indicating a sustained period of greater effective moisture, optimal for spring discharge and black mat formation.

  5. Glacier equilibrium line altitudes as palaeoclimatic information sources - examples from the Alpine Younger Dryas.

    Science.gov (United States)

    Kerschner, H.; Sailer, R.; Hertl, A.; Schuh, M.

    2003-04-01

    Equilibrium line altitudes (ELA) and flucutations of the ELA (dELA) of well dated glacial advances are valuable terrestrial sources for palaeoclimatic information, which are physically well understood (Kuhn 1981, Kaser and Osmaston 2001). Values of dELA can be used to infer quantitatively standard climatic parameters like precipitation and precipitation change. ELAs of former glaciers are usually calculated from maps of the glacier topography based on the moraines and related geomorphological features. Then either the analytical glacial-meterological model for ELA fluctuations by Kuhn (1981) or the statistical parameterization of the climate at the ELA in terms of "summer temperature" and "precipitation" by Ohmura et al. (1992) can be used for palaeoclimatic interpretation. As dELA is influenced both by factors governing accumulation and ablation, some external climatic information on one parameter is necessary to obtain the other. Moraines of the Younger Dryas "Egesen-Stadial" can be found throughout the Alps. Early Younger Dryas (Egesen-I, Ivy-Ochs et al. 1996) dELAs show a distinct spatial pattern. They were highest (ca. 450-600 m against "present-day") in areas exposed towards the West and Northwest. In the central valleys, it was in the order of -300 m and less. Presently, almost 200 data points are available. Summer temperature depression (dTs) can be derived from the Younger Dryas timberline depression and other proxy data (Ammann and Oldfield 2000). It seems to be in the order of -3.5 K in the central Alps. Along the northern and western fringe of the Alps, it may be somewhat larger (-4 to -4.5 K). dELA and dTs values are then used to calculate precipitation change (dP). Early Younger Dryas climate in the central valleys of the Alps seems to have been considerably drier than today (dP -30%). In areas open to the West and Northwest, precipitation seems to have been the same as today or even slightly higher (dP 0 - +10%). These results agree well with the

  6. Absence of Cooling in New Zealand and the Adjacent Ocean During the Younger Dryas Chronozone

    Science.gov (United States)

    Barrows, Timothy T.; Lehman, Scott J.; Fifield, L. Keith; De Deckker, Patrick

    2007-10-01

    As the climate warmed at the end of the last glacial period, a rapid reversal in temperature, the Younger Dryas (YD) event, briefly returned much of the North Atlantic region to near full-glacial conditions. The event was associated with climate reversals in many other areas of the Northern Hemisphere and also with warming over and near Antarctica. However, the expression of the YD in the mid- to low latitudes of the Southern Hemisphere (and the southwest Pacific region in particular) is much more controversial. Here we show that the Waiho Loop advance of the Franz Josef Glacier in New Zealand was not a YD event, as previously thought, and that the adjacent ocean warmed throughout the YD.

  7. A new concept for paleohydrological evolution of the Younger Dryas in NE Brazil

    Science.gov (United States)

    Bouimetarhan, Ilham; Prange, Matthias; Gonzalez, Catalina; Dupont, Lydie

    2016-04-01

    The late deglacial interval from approximately 13 to 11 kyr BP contains some of the best documented abrupt climate changes in the Past, the Younger Dryas (YD). It is also an interval when the bipolar climatic signature of millennial-scale changes in the Atlantic meridional overturning circulation (AMOC) is well expressed. Here we present a high-resolution palynological record from core GeoB16205-4 (1°21.11'N, 43°05.80'W), retrieved off the Parnaíba River mouth, southeast of the Amazon River (~1955 m water depth). Pollen and organic-walled dinoflagellate cyst assemblages indicate a predominantly wet climate during the YD in the nowadays semi-arid Nordeste, whereby a second phase between ~12.3 and 11.7 kyr BP is wetter than the period before. This is recorded by a strong increase in the concentrations of river plume dinoflagellate cyst assemblages indicative of a stratified surface water column and reduced salinity environments, as well as a drop in grass pollen and microcharcoal particle concentrations along with strong fluctuations in the representation of rain forest, gallery forest and tree ferns suggesting year-round humid conditions. This shift from a relatively wet first phase to a much wetter second phase is in agreement with the transient TRACE-21k coupled climate model simulation which shows a first pluvial Parnaíba stage from ~12.8 to 12.3 kyr BP and a second stronger pluvial stage between ~12.3 and 11.7 kyr BP to be related to a very weak AMOC due to meltwater pulses in the North Atlantic. The AMOC variation induces a steep temperature gradient between the Southern and the Northern Hemisphere which forces a southward shift of the Intertropical Convergence Zone (ITCZ) and its associated rainfall. The two-step hydroclimatic and environmental evolution during the Younger Dryas has not been documented previously in this region.

  8. Younger Dryas To Mid-Holocene Environmental History Of The Lowlands Of NW Transylvania, Romania

    Science.gov (United States)

    Feurdean, A.; Mosbrugger, V.; Onac, B. P.; Polyak, V.; Veres, D.

    2007-12-01

    Pollen, micro-charcoal and total carbon analyses on sediments from the Turbuta profile located in the Transylvanian Basin (NW Romania) reveal information on previously unknown Younger Dryas to mid-Holocene environmental changes. The chronostratigraphy relies on AMS 14C measurements on organic matter and U/Th TIMS datings of snail shells. Results indicate the presence of Pinus and Betula open woodlands with small populations of Picea, Ulmus, Alnus and Salix before 12,000 cal yr BP, correlates well with the environmental developments expected for Younger Dryas stadial. A fairly abrupt replacement of Pinus and Betula by Ulmus dominated woodlands at ca. 11,900 cal. yr BP, likely represents competition effects of vegetation driven by climate warming at the onset of the Holocene. By 11,000 cal yr BP, the woodlands were increasingly diverse and dense with the expansion of Quercus, Fraxinus and Tilia, the establishment of Corylus, and the decline of upland herbaceous and shrubs taxa. The marked expansion of Quercus accompanied by Tilia between 10,500 and 8,000 cal yr BP could be the result of low effective moisture associated with both low elevation of the site and with regional change towards a drier climate. At 10,000 cal. yr BP Corylus spread across the region, and by 8,000 cal yr BP it replaced Quercus as a dominant forest constituent, with only little representation of Picea abies. Carpinus became established around 5,500 cal yr BP, but it was only a minor constituent in local woodlands until ca. 5,000 cal yr BP. Results from this study also indicate that the woodlands in the lowlands of Turbuta were never closed.

  9. Bayesian chronological analyses consistent with synchronous age of 12,835-12,735 Cal BP for Younger Dryas boundary on four continents

    DEFF Research Database (Denmark)

    Kennett, James P.; Kennett, Douglas J.; Culleton, Brendan J.

    2015-01-01

    The Younger Dryas impact hypothesis posits that a cosmic impact across much of the Northern Hemisphere deposited the Younger Dryas boundary (YDB) layer, containing peak abundances in a variable assemblage of proxies, including magnetic and glassy impact-related spherules, high-temperature mineral...

  10. Rapid response of alpine timberline vegetation to the Younger Dryas climate oscillation in the Colorado Rocky Mountains, USA

    Science.gov (United States)

    Reasoner, Mel A.; Jodry, Margret A.

    2000-01-01

    Paleobotanical records from two high-altitude (>3300 m) sites in Colorado show a clear and immediate response to the Younger Dryas climate oscillation. The Black Mountain Lake and Sky Pond records indicate that alpine timberline migrated upslope to near-modern elevations during the late Bølling-Allerød (13.6 12.9 ka). Subsequent declines in arboreal pollen percentages and accumulation rates during the Younger Dryas interval (12.9 11.7 ka) reflect a downslope displacement of the alpine timberline ecotone of 60 120 m in elevation. This change translates to a cooling of summer temperature by ˜0.4 0.9 °C and is consistent with proposed Younger Dryas advances of alpine glaciers in the Rocky Mountains to positions close to Little Ice Age maxima. Alpine timberline readvanced upslope to elevations above both sites between 11.7 and 11.4 ka. The concomitant response of temperature-sensitive alpine timberline vegetation in Colorado and late-glacial changes in North Atlantic thermohaline circulation implicates a rapid, widespread atmospheric transmission of the Younger Dryas climate oscillation.

  11. Younger Dryas equilibrium line altitudes and precipitation patterns in the Alps

    Science.gov (United States)

    Kerschner, Hanns; Moran, Andrew; Ivy-Ochs, Susan

    2016-04-01

    Moraine systems of the "Egesen Stadial" are widespread and easily identifiable features in the Alps. Absolute dating with terrestrial cosmogenic radionuclides shows that the maximum extent was reached during the early Younger Dryas (YD), probably as a reaction to the intense climatic downturn subsequent to Lateglacial Interstadial. In recent years, several new studies and the availability of high-quality laser-scan hillshades and orthophotos allowed a significant extension of the database of YD glaciers as "palaeoprecipitation gauges" to large hitherto unmapped regions in the Austrian and Swiss Alps. The equilibrium line altitude (ELA) of the glaciers and its lowering relative to the Little Ice Age ELA (dELA) shows a distinct and systematic spatial pattern. Along the northern slope of the Alps, dELAs are usually large (around 400 m and perhaps even more), while dELAs range around 200 m in the well sheltered areas of the central Alps, e.g. in the Engadine and in western Tyrol. Both stochastic glacier-climate models (e.g. Ohmura et al. 1992) and the heat- and mass balance equation (Kuhn 1981) allow the reconstruction of precipitation change under the assumption of a spatially constant summer temperature depression, which in turn can be estimated from biological proxies. This allows to draw the spatial pattern of precipitation change with considerable detail. Precipitation change is clearly controlled by the local relief like high mountain chains, deeply incised and long valleys and mountain passes. Generally the contrast between the northern fringe of the Alps and the interior was more pronounced than today. Climate in the Northern and and Northwestern Alps was rather wet with precipitation totals eventually exceeding modern annual sums. The central Alps received 20 - 30% less precipitation than today, mainly due to reduced winter precipitation. In the southern Alps, still scarce spatial information points to precipitation sums which were approximately similar to

  12. Late Pleistocene Megafaunal Extinction Consistent With YDB Impact Hypothesis at Younger Dryas Onset

    Science.gov (United States)

    Kennett, J. P.; Kennett, D. J.

    2008-12-01

    At least 35 mammal and 19 bird genera became extinct across North America near the end of the Pleistocene. Modern increases in stratigraphic and dating resolution suggest that this extinction occurred relatively rapidly near 12.9 ka (11 radiocarbon kyrs). Within the context of a long-standing debate about its cause, Firestone et al., (2007) proposed that this extinction resulted from an extraterrestrial (ET) impact over North America at 12.9 ka. This hypothesis predicts that the extinction of most of these animals should have occurred abruptly at 12.9 ka. To test this hypothesis, we have critically examined radiocarbon ages and the extinction stratigraphy of these taxa. From a large data pool, we selected only radiocarbon dates with low error margins with a preference for directly dated biological materials (e.g., bone, dung, etc.) and modern chemical purification techniques. A relatively small number of acceptable dates indicate that at least 16 animal genera and several other species became extinct close to 12.9 ka. These taxa include the most common animals of the late Pleistocene such as horses, camels, and mammoths. Also, the remains of extinct taxa are reportedly found up to, but not above, the base of a widely distributed carbon-rich layer called the black mat. This stratum forms an abrupt, major biostratigraphic boundary at the Younger Dryas onset (12.9 ka), which also contains multiple ET markers comprising the impact layer (the YDB). Surviving animal populations were abruptly reduced at the YDB (e.g., Bison), with major range restrictions and apparent evolutionary bottlenecks. The abruptness of this major extinction is inconsistent with the hypotheses of human overkill and climatic change. We argue that extinction ages older than 12.9 ka for many less common species result from the Signor-Lipps effect, but the impact hypothesis predicts that as new dates are acquired, they will approach ever closer to 12.9 ka. The megafaunal extinction is strongly

  13. Comment on 'Was Scotland deglaciated during the Younger Dryas?' by Small and Fabel (2016)

    Science.gov (United States)

    Bromley, Gordon R. M.; Putnam, Aaron E.; Lowell, Thomas V.; Hall, Brenda L.; Schaefer, Joerg M.

    2016-11-01

    The course of climatic events in Scotland and the broader North Atlantic region during the glacial termination has important implications for our understanding of the causes and mechanisms of abrupt climate change but remains in debate. One example is the timing of the late-glacial 'Loch Lomond Readvance' (LLR), during which an ice cap and numerous cirque glaciers were nourished in the Scottish Highlands. Exactly when the LLR occurred and culminated has been disputed for several decades and has been addressed via several different types of chronologic evidence (e.g., Lowe and Walker, 1976; Golledge et al., 2007; MacLeod et al., 2011; Bromley et al., 2014). Recently, Small and Fabel (2016) presented a suite of six 10Be surface-exposure ages from moraine ridges on Rannoch Moor, central Scottish Highlands, that questioned whether two different dating techniques - 10Be and 14C - yield the same result for the timing of final deglaciation of the Scottish ice cap. In that study, Small and Fabel (2016) concluded that the 10Be data show deglaciation occurred at the close of the Younger Dryas (YD) stadial (∼11.6 kyr), as much as a millennium later than the scenario presented by Bromley et al. (2014) based on minimum-limiting 14C data. While the issue of which, if either, is a more reliable age for deglaciation cannot be resolved fully in a short note, we comment on several points raised by Small and Fabel (2016) and suggest a means to resolve this question.

  14. Exploring the Human Ecology of the Younger Dryas Extraterrestrial Impact Event

    Science.gov (United States)

    Kennett, D. J.; Erlandson, J. M.; Braje, T. J.; Culleton, B. J.

    2007-05-01

    Several lines of evidence now exist for a major extraterrestrial impact event in North America at 12.9 ka (the YDB). This impact partially destabilized the Laurentide and Cordilleran ice sheets, triggered abrupt Younger Dryas cooling and extensive wildfires, and contributed to megafaunal extinction. This event also occurred soon after the well established colonization of the Americas by anatomically modern humans. Confirmation of this event would represent the first near-time extraterrestrial impact with significant effects on human populations. These likely included widespread, abrupt human mortality, population displacement, migration into less effected or newly established habitats, loss of cultural traditions, and resource diversification in the face of the massive megafaunal extinction and population reductions in surviving animal populations. Ultimately, these transformations established the context for the special character of plant and animal domestication and the emergence of agricultural economies in North America. We explore the Late Pleistocene archaeological record in North America within the context of documented major biotic changes associated with the YDB in North America and of the massive ecological affects hypothesized for this event.

  15. Lacustrine lignin biomarker record reveals a severe drought during the late Younger Dryas in southern Taiwan

    Science.gov (United States)

    Ding, Xiaodong; Bao, Hongyan; Zheng, Liwei; Li, Dawei; Kao, Shuh-Ji

    2017-03-01

    The Younger Dryas (YD) event, which punctuated the last glacial-Holocene transition period and had a profound impact on global climate, is the most well studied millennial-scale climate event although the triggering mechanism remains debate. Weakened Asian summer monsoon during the YD is recorded in oxygen isotopes of stalagmite from Mainland China. However, lacustrine climate record of the YD event has not been reported from the subtropical land-ocean boundary of the Asian continent near the Pacific warm pool. We provide a lignin biomarker record covering the last deglaciation and early Holocene (17-9 ka BP) from the Dongyuan Lake, southern Taiwan, located at the frontal zone of typhoon invasion. The lignin phenol ratio S/V shows that the vegetation in the catchments had shifted from gymnosperm dominant to angiosperm dominant plants since 12.2 ka BP. Significantly decreased lignin concentrations (TLP and λ8) and elevated lignin degradation parameters ((Ad/Al)v, P/(V + S), DHBA/V) in combination with other organic proxies (TOC, δ13Corg) during the late YD suggest a severe drought had occurred in southern Taiwan during this specific period. Changes in the lignin proxies from the Dongyuan Lake lagged the climate changes registered in stalagmite records by around 500-800 years, suggesting a slow response of vegetation and soil processes to rapid climate changes.

  16. Field-Analytical approach of land-sea records for elucidating the Younger Dryas Boundary syndrome

    Science.gov (United States)

    Ge, T.; Courty, M. M.; Guichard, F.

    2009-12-01

    contrast, microfacies and debris composition of the recurrent fine dust/wildfire events would trace a series of a low energy airburst. Their record is expressed in the Audenge sequence by a series of water-laid laminae of charred pine residues formed of carbonaceous spherules wrapped by carbonaceous polymers that includes lonsdaleite crystals as detected by high resolution in situ micro-Raman analysis. This association suggests recurrent flash forest wildfires ignited by hot spray of carbon-rich debris, followed by heavy snow falls. The record from the Peruvian desert suggests a possible linkage between the repeated debris fall/wildfires during the Younger Dryas and the following irreversible aridity along the Peruvian cost. In contrast the Caspian record of the Younger Dryas period indicates more gradual changes, possibly buffered by the hydrological functioning of the Caspian sea in a complex region. The Audenge context offers the amplified signal needed to understand at local to global scales the spatio-temporal pattern of impact-airburst events.

  17. The Tintah-Campbell gap and implications for glacial Lake Agassiz drainage during the Younger Dryas cold interval

    Science.gov (United States)

    Breckenridge, Andy

    2015-06-01

    Reconstructions of glacial Lake Agassiz paleogeography and drainage have been an important contribution to formulating a hypothesis in which glacial Lake Agassiz drainage to the Atlantic Ocean initiated the Younger Dryas cold interval. This study evaluates the lake level and outlet history of Lake Agassiz as recorded by strandlines visible on lidar digital elevation models from North Dakota and Minnesota. The former lake levels are warped due to glacial isostatic adjustment. Older levels have experienced more uplift and therefore have more curvature. The strandline data establish that the Moorhead lowstand of Lake Agassiz was bracketed by the strongly diverging Campbell and Tintah lake levels, which creates a vertical gap between the former lake levels. This gap exists due to a lake level drop of ˜90 m when the Laurentide Ice Sheet retreat opened a lower outlet, which must have been a northwest outlet to the Arctic Ocean. By applying an exponential decay rebound model, this event dates to 12,180 ± 480 cal yr BP, post-dating the beginning of the Younger Dryas at 12,900 cal yr BP. Eastern drainage outlets to the Atlantic Ocean through the Laurentian Great Lakes that were contemporaneous with the onset of the Younger Dryas cannot be ruled out, but if these outlets existed, their duration of occupation was short-lived and not characterized by significant drawdown events within glacial Lake Agassiz.

  18. Climate change, patch choice, and intensification at Pont d'Ambon (Dordogne, France) during the Younger Dryas

    Science.gov (United States)

    Jones, Emily Lena

    2009-11-01

    This paper considers the impact of the Younger Dryas on the prehistoric inhabitants of Pont d'Ambon, a site in the Dordogne region of southwestern France, through an examination of the zooarchaeological remains from this site. An investigation of patch choice indicates that patch choice evenness declines during the Younger Dryas due to increasing local dominance of the grassland patch. Analyses of demographic composition, cutmark frequency, and marrow processing in the wild European rabbit ( Oryctolagus cuniculus) assemblage suggest intensified rabbit use during this period. This study thus supports the hypothesis that changing climate had significant impacts on the prehistoric inhabitants of Pont d'Ambon. However, the traditional climate hypothesis—that changing climate negatively impacted the availability of larger fauna, forcing a switch to smaller, lower-ranked prey items—is not supported here. The inhabitants of Pont d'Ambon seem to have adapted to changing climate by efficiently exploiting the new species available to them, and possibly, during the Younger Dryas, by intensifying their use of one of these new species, the European rabbit.

  19. A Younger Dryas re-advance of local glaciers in north Greenland

    Science.gov (United States)

    Larsen, Nicolaj K.; Funder, Svend; Linge, Henriette; Möller, Per; Schomacker, Anders; Fabel, Derek; Xu, Sheng; Kjær, Kurt H.

    2016-09-01

    The Younger Dryas (YD) is a well-constrained cold event from 12,900 to 11,700 years ago but it remains unclear how the cooling and subsequent abrupt warming recorded in ice cores was translated into ice margin fluctuations in Greenland. Here we present 10Be surface exposure ages from three moraines in front of local glaciers on a 50 km stretch along the north coast of Greenland, facing the Arctic Ocean. Ten ages range from 11.6 ± 0.5 to 27.2 ± 0.9 ka with a mean age of 12.5 ± 0.7 ka after exclusion of two outliers. We consider this to be a minimum age for the abandonment of the moraines. The ages of the moraines are furthermore constrained using Optically Stimulated Luminescence (OSL) dating of epishelf sediments, which were deposited prior to the ice advance that formed the moraines, yielding a maximum age of 12.4 ± 0.6 ka, and bracketing the formation and subsequent abandonment of the moraines to within the interval 11.8-13.0 ka ago. This is the first time a synchronous YD glacier advance and subsequent retreat has been recorded for several independent glaciers in Greenland. In most other areas, there is no evidence for re-advance and glaciers were retreating during YD. We explain the different behaviour of the glaciers in northernmost Greenland as a function of their remoteness from the Atlantic Meridional Overturning Circulation (AMOC), which in other areas has been held responsible for modifying the YD drop in temperatures.

  20. How Synchronous was the Transition into the Younger Dryas across the Euro-Atlantic Region?

    Science.gov (United States)

    Schenk, F.; Muschitiello, F.; Heikkilä, M. P.; Väliranta, M.; Tarasov, L.; Brandefelt, J.; Johansson, A. V.; Naslund, J. O.; Wohlfarth, B.

    2015-12-01

    Observations of a currently weakening subpolar gyre south of Greenland has again increased scientific attention regarding the role of the Atlantic Meridional Overturning Circulation (AMOC) for the regional to global climate. The rapid climate shift of the Younger Dryas (YD, GS-1) cold reversal during the last deglaciation is attributed to an abrupt slowdown or collapse of the AMOC due to a strong meltwater pulse and/or the rapid disintegration of the Laurentide Ice sheet. Although such a dramatic event is not expected for the future, the spatiotemporal climatic response to such a slowdown is an interesting test case. Two recently well dated proxy records around the North Sea region suggest a non-synchronous early cooling/onset of the YD compared to Greenland (NGRIP). Presentation #61803 discusses the hypothesis of a local cooling as a response to increased ice berg calving and/or meltwater from Fenno-Scandinavian Ice Sheet (FIS) during the late Alleröd warm phase (GI-1a). Here we study CCSM3 model output from the quasi-transient atmosphere-ocean simulation (TraCE) where no strong contribution from FIS is considered from the late Alleröd into the YD. We evaluate to which extent the spatiotemporal temperature response to the AMOC slowdown of the simulation is synchronous over the Euro-Atlantic region and how atmospheric teleconnections reorganize during the rapid shift into the YD. In addition, we run time-slice experiments at high spatial resolution of around 100 km with the Community Earth System Model CESM1.0.5 for the late Alleröd and YD to compare spatial climatic differences for both periods taking into account the regional influence from continental ice sheets in more detail.

  1. Decadal resolved leaf wax δD records of the Younger Dryas in central and eastern Europe

    Science.gov (United States)

    Aichner, Bernhard; Słowiński, Michał; Ott, Florian; Noryśkiewicz, Agnieszka M.; Wulf, Sabine; Brauer, Achim; Sachse, Dirk

    2015-04-01

    Annually laminated (varved) sediments with defined event-based age anchor points such as tephra layers enable the establishment of precise chronologies in lacustrine climate archives. This is especially useful to study subtle temporal differences in the consequences of mechanisms and feedbacks during abrupt climatic changes such as the Younger Dryas over larger spatial areas. To decipher the drivers of ecological changes across the Allerød/Younger Dryas transition in central Europe, we analyzed leaf wax biomarkers from Trzechowskie paleolake in northern Poland. Samples were taken in 10 years intervals across the onset of the Younger Dryas, with the Laacher See Tephra (12,880 yrs BP) as anchor point for age-calibration. Further, we applied compound specific hydrogen isotope analysis to infer past hydrological changes, in comparison to results from the well-dated Meerfelder Maar record located up 900 km to the southwest [1]. Between 12,750 and 12,600 yrs BP, ratios of terrestrial n-alkanes show a transition from a tree-dominated lake catchment (Pinus, Betula) to an environment mainly covered by Juniperus and grasses, which is in agreement with palynological data. δD values of n-alkanes indicate a rapid cooling and/or a change of moisture source together with a slight aridification between 12,680 and 12,600 yrs BP. This is synchronous to a rapid and strong aridification inferred for the beginning of the Younger Dryas at Meerfelder Maar (western Germany) [1] but ca. 170 yrs after the inferred onset of cooling at both Meerfelder Maar and the NGRIP ice core at 12,850 yrs BP. This highlights a different temporal succession and impact of hydrological and climatic changes in eastern compared to western Europe which could potentially be related to the stronger influence of the Fennoscandian icesheets and/or the Siberian High on atmospheric circulation patterns in the more continental climate influenced parts of eastern Europe. [1] Rach O, Brauer A, Wilkes H, Sachse D

  2. Testing Younger Dryas ET Impact (YDB) Evidence at Hall’s Cave, Texas

    Science.gov (United States)

    Stafford, T. W.; Lundelius, E.; Kennett, J.; Kennett, D. J.; West, A.; Wolbach, W. S.

    2009-12-01

    soot at 2400 ppm, magnetic spherules, and carbon spherules, all of which we interpret as evidence for a unique chronostratigraphic marker (YDB) in the Western Hemisphere. Because the age of this horizon is ~ 13,000 CAL BP, we interpret the age of the event as the beginning of the Younger Dryas cooling. Regional soil erosion began ~15,000 CAL BP and continued until 7000 CAL BP, but dating suggests that there is no discontinuity or hiatus in deposition, and thus, the exotic materials in that layer are not considered to be erosional accumulations. Future analyses include sub-centimeter sampling over the YD boundary, quantification of nanodiamonds and other event-proxies within 1000 yr of the boundary and in sediments several 1000 years older and younger, continued refinement of the AMS 14C record to determine within 50 yr the location of 12,900 CAL BP datum and high resolution analysis of small animal biostratigraphy.

  3. Proliferation and demise of deep-sea corals in the Mediterranean during the Younger Dryas

    Science.gov (United States)

    McCulloch, Malcolm; Taviani, Marco; Montagna, Paolo; López Correa, Matthias; Remia, Alessandro; Mortimer, Graham

    2010-09-01

    Uranium-series and radiocarbon ages are reported for deep-sea corals Madrepora oculata, Desmophyllum dianthus, Lophelia pertusa and Caryophyllia smithii from the Mediterranean Sea. U-series dating indicates that deep-sea corals have persisted in the Mediterranean for over 480,000 years, especially during cool interstadial periods. The most prolific period of growth however appears to have occurred within the Younger Dryas (YD) period from 12,900 to 11,700 years BP followed by a short (~ 330 years) phase of post-YD coral growth from 11,230 to 10,900 years BP. This indicates that deep-sea corals were prolific in the Mediterranean not only during the return to the more glacial-like conditions of the YD, but also following the rapid deglaciation and transition to warmer conditions that followed the end of the YD. Surprisingly, there is a paucity Last Glacial Maximum (LGM) coral ages, implying they were largely absent during this period when cold-water conditions were more prevalent. Radiocarbon ages show that the intermediate depth waters of the Mediterranean generally had Δ 14C compositions similar to surface waters, indicating that these waters were extremely well ventilated. The only exception is a narrow period in the YD (12,500 ± 100 years BP) when several samples of Lophelia pertusa from the Ionian Sea had Δ 14C values falling significantly below the marine curve. Using a refined approach, isolation ages (τ isol) of 300 years to 500 years are estimated for these intermediate (800-1000 m) depth waters relative to surface marine waters, indicating a reduction or absence of deep-water formation in the Ionian and adjacent Adriatic Seas during the YD. Contrary to previous findings, we find no evidence for widespread intrusion of low Δ 14C Atlantic waters into the Mediterranean. Prolific growth of deep-sea corals in the Mediterranean ended abruptly at ~ 10,900 years BP, with many of the coral-bearing mounds on the continental slopes being draped in a thin veneer

  4. Proliferation and demise of deep-sea corals in the Mediterranean during the Younger Dryas

    Energy Technology Data Exchange (ETDEWEB)

    McCulloch, Malcolm [ARC Centre of Excellence for Coral Reef Studies, School of Earth and Environment, The University of Western Australian, Crawley, 6009, Western Australia (Australia); Research School of Earth Sciences, Australian National University, Canberra, 0200 (Australia); Taviani, Marco; Lopez Correa, Matthias; Remia, Alessandro [ISMAR-CNR, via Gobetti 101, I-40129 Bologna (Italy); Montagna, Paolo [LSCE, Av. de la Terrasse, 91198 Gif-sur-Yvette, France, ISMAR-CNR, via Gobetti 101, I-40129 Bologna (Italy); Mortimer, Graham [Research School of Earth Sciences, Australian National University, Canberra, 0200 (Australia)

    2010-07-01

    Uranium-series and radiocarbon ages are reported for deep-sea corals Madrepora oculata, Desmophyllum dianthus, Lophelia pertusa and Caryophyllia smithii from the Mediterranean Sea. U-series dating indicates that deep-sea corals have persisted in the Mediterranean for over 480, 000 years, especially during cool inter-stadial periods. The most prolific period of growth however appears to have occurred within the Younger Dryas (YD) period from 12, 900 to 11, 700 years BP followed by a short ({approx} 330 years) phase of post-YD coral growth from 11, 230 to 10, 900 years BP. This indicates that deep-sea corals were prolific in the Mediterranean not only during the return to the more glacial-like conditions of the YD, but also following the rapid deglaciation and transition to warmer conditions that followed the end of the YD. Surprisingly, there is a paucity Last Glacial Maximum (LGM) coral ages, implying they were largely absent during this period when cold-water conditions were more prevalent. Radiocarbon ages show that the intermediate depth waters of the Mediterranean generally had {Delta}{sup 14}C compositions similar to surface waters, indicating that these waters were extremely well ventilated. The only exception is a narrow period in the YD (12, 500 {+-} 100 years BP) when several samples of Lophelia pertusa from the Ionian Sea had {Delta}{sup 14}C values falling significantly below the marine curve. Using a refined approach, isolation ages (T{sub isol}) of 300 years to 500 years are estimated for these intermediate (800-1000 m) depth waters relative to surface marine waters, indicating a reduction or absence of deep-water formation in the Ionian and adjacent Adriatic Seas during the YD. Contrary to previous findings, we find no evidence for widespread intrusion of low {Delta}{sup 14}C Atlantic waters into the Mediterranean. Prolific growth of deep-sea corals in the Mediterranean ended abruptly at {approx} 10, 900 years BP, with many of the coral-bearing mounds

  5. Stable isotope record from Seneca Lake, New York: Evidence for a cold paleoclimate following the Younger Dryas

    Science.gov (United States)

    Anderson, William T.; Mullins, Henry T.; Ito, Emi

    1997-02-01

    A radiocarbon controlled stable isotope record from Seneca Lake, New York, has defined a relatively cold paleoclimate (10.1 8.2 ka) that was younger, and regionally of greater magnitude, than the well-known Younger Dryas cold interval. These new isotope results are supported by published pollen records, from throughout the Great Lakes region, that also define a relatively cold paleoclimate at this time. This cold paleoclimate occurred during global meltwater pulse IB when large volumes of cold, isotopically light (low δ18O) meltwater flowed into the Great Lakes from the rapidly retreating Laurentide ice sheet. The discharge of cold glacial meltwaters into the Great Lakes during pulse IB suppressed downwind summer temperatures in the Finger Lakes region and provided a source of isotopically light precipitation. Published proxy data from Greenland, Norway, and Alaska also record relatively cold paleoclimates following the Younger Dryas, suggesting widespread Northern Hemisphere cooling as a direct result of the rapid melting of the Laurentide ice sheet between 10 and 8 ka.

  6. A quantitative reconstruction of changes in relative humidity during the Younger Dryas in Western Europe

    Science.gov (United States)

    Rach, O.; Kahmen, A.; Brauer, A.; Sachse, D.

    2013-12-01

    Hydroclimatic changes have a profound effect on terrestrial ecosystems from regional to continental scales. However, past hydrological changes linked to abrupt climate shifts and their effect on terrestrial ecosystems are not well understood due to the lack of direct quantitative hydrological reconstructions. In addition, most paleoclimate proxies record the environmental response to hydrological variations, such as vegetation changes inferred by changes in pollen abundance, rather than hydroclimatic change itself. Over the last decade hydrogen isotope ratios (δD value) of lipid biomarkers have emerged as a novel and direct hydrological proxy, since it aims to reconstruct the δD values of the water source used by photosynthetic organisms. However, the hydrogen isotope ratio of source water (such as precipitation) is an integrated signal of condensation temperature, moisture pathway, precipitation amount and evaporation. As such, it is difficult to separate a single parameter, for example relative humidity, required for a true quantitative interpretation. Here we present a novel approach to quantify changes in relative humidity (Δrh) based on the hydrogen isotope composition of terrestrial and aquatic n-alkanes. In this proof-of-concept study we generate a high-resolution Δrh record for the Younger Dryas period (YD) of Western Europe from Lake Meerfelder Maar, (MFM, Germany). We use aquatic macrophyte biomarker δD values as a recorder of lake water δD (aq), which represents an integrated annual precipitation signal, and terrestrial leaf wax n-alkane δD values (terr) as a record of leaf-water evapotranspiration. Therefore we consider the isotopic difference between δDterr and δDaq (ɛterr-aq) as a measure of mean leaf water enrichment (ΔL), which is mainly controlled by relative humidity and temperature. By employing a modified and parameterized Craig-Gordon leaf-water model we are able to extract past changes in relative humidity from a sedimentary record

  7. Younger Dryas thermohaline circulation in the N-Atlantic: Irminger Sea versus Norwegian Sea Basin

    Science.gov (United States)

    Kuijpers, Antoon; Seidenkrantz, Marit-Solveig; Luise Knudsen, Karen; Knutz, Paul C.; Sicre, Marie-Alexandrine; Andresen, Camilla S.; Pearce, Christof

    2016-04-01

    Oceanographic observations from the early 1990's show a marked cooling and freshening of the Nordic Seas due to eastward expansion of East Greenland Current derived Polar Waters under influence of strong zonal atmospheric circulation(1). For the cold Younger Dryas (YD) period, ca 12,900 - 11,600 years ago, the impact of Northern Hemisphere late glacial melt water pulses on N- Atlantic thermohaline circulation has been discussed as a likely mechanism for cooling. Melt water discharge sources have been a matter of much debate, but recent evidence point to important melt water pulses emanating from the Arctic region (2, e.g. MacKenzie Valley discharge). The largest volume of these fresh water masses reached the North Atlantic via Fram Strait, less through the Canadian archipelago. During preceding Bølling-Allerød warming, the size of the Laurentide Ice Sheet may have been still large enough to have influenced atmospheric planetary waves resulting in a more zonal Atlantic jet axis(3). In addition, Northern Hemisphere high summer insolation favored a northward displaced west wind belt forcing surface waters away from the Greenland coast. Hence, in analogue to recent observations, ice-loaded meltwater masses in the western Greenland Sea were forced eastward, creating a pool of cold,low salinity (ice-loaded) surface water masses in the Norwegian Sea(4), while transport of cold Polar Water via Denmark Strait to the Irminger Sea would be suppressed. Our own sediment core data from offshore Iceland, Greenland and Davis Strait(5,6,7)together with results from lake studies in southern Greenland(8) point to an active Irminger Current and well-developed Irminger Sea Water subsurface transport towards Davis Strait. Subsequent incorporation of the latter water mass into the south-flowing Labrador Current may have contributed to tidewater glacier melting in eastern Canada and eventually triggering of the H0 meltwater pulse. The sediment core data indicate Irminger Sea deep

  8. Early-Warning Signals for the onsets of Greenland Interstadials and the Younger Dryas-Preboreal transition

    CERN Document Server

    Rypdal, M

    2015-01-01

    The high-frequency band of the $\\delta^{18}\\mbox{O}$ variations in the North Greenland Ice Core Project displays fluctuation levels that increase as one approaches the onset of an interstadial (warm) period. For some of the events it is possible to establish statistical significance using Monte-Carlo simulations with a non-parametric null model with random phases and the same spectral density as the $\\delta^{18}\\mbox{O}$ record during the stadial periods. Similar results are found for the locally estimated Hurst exponent for the high-frequency fluctuations, and it is therefore natural to interpret these findings as so-called "critical slowing down" signatures, i.e. early-warning signs of tipping points. The observed "slowing down" is found to be similar (and perhaps even stronger) in the Younger Dryas, suggesting that there are some similarities between mechanisms of the Younger Dryas-Preboreal transition and the onsets of the Greenland interstadials. It is also verified that the temperature fluctuations duri...

  9. Absence of geochemical evidence for an impact event at the Bølling-Allerød/Younger Dryas transition.

    Science.gov (United States)

    Paquay, François S; Goderis, Steven; Ravizza, Greg; Vanhaeck, Frank; Boyd, Matthew; Surovell, Todd A; Holliday, Vance T; Haynes, C Vance; Claeys, Philippe

    2009-12-22

    High concentrations of iridium have been reported in terrestrial sediments dated at 12.9 ka and are interpreted to support an extraterrestrial impact event as the cause of the observed extinction in the Rancholabrean fauna, changes in the Paleoindian cultures, and the onset of the Younger Dryas cooling [Firestone RB, et al. (2007) Proc Natl Acad Sci USA 104:16016-16021]. Here, we report platinum group element (PGE: Os, Ir, Ru, Rh, Pt, Pd), gold (Au) concentrations, and (187)Os/(188)Os ratios in time-equivalent terrestrial, lacustrine, and marine sections to seek robust evidence of an extraterrestrial contribution. First, our results do not reproduce the previously reported elevated Ir concentrations. Second, (187)Os/(188)Os isotopic ratios in the sediment layers investigated are similar to average crustal values, indicating the absence of a significant meteoritic Os contribution to these sediments. Third, no PGE anomalies distinct from crustal signatures are present in the marine record in either the Gulf of California (DSDP 480, Guaymas Basin) or the Cariaco Basin (ODP 1002C). Our data show no evidence of an extraterrestrial (ET)-PGE enrichment anomaly in any of the investigated depositional settings investigated across North America and in one section in Belgium. The lack of a clear ET-PGE signature in this sample suite is inconsistent with the impact of a large chondritic projectile at the Bølling-Allerød/Younger Dryas transition.

  10. Hydrological and vegetational response to the Younger Dryas climatic oscillations: a high resolution case study from Quoyloo Meadow, Orkney, Scotland

    Science.gov (United States)

    Maas, David; Abrook, Ashley; Timms, Rhys; Matthews, Ian; Palmer, Adrian; Milner, Alice; Candy, Ian; Sachse, Dirk

    2016-04-01

    The Younger Dryas (Loch Lomond) Stadial is a well defined period of cold climate that in North West Europe punctuated the climatic amelioration during the Last Glacial - Interglacial Transition (LGIT ca. 16-8 ka). A palaeolake record from Quoyloo Meadow, Orkney Islands (N59.067, E-3.309) has been analysed for pollen and stable isotopes on biomarker lipids. n-Alkanes from terrestrial and aquatic sources are present throughout the core. The average chain length (ACL) is relatively low during the interstadial (~28.0) and shows a distinct increase during the Younger Dryas (to 29.0 +), attributed to an increase in grasses and drought resistant shrubs (e.g. Artemisia, Castañeda et al., 2009, Bunting, 1994). At the beginning of the Holocene, the ACL rapidly drops to 28.3 and from thereon gently increases again to ~29.0. There is a continued odd-over-even n-alkane predominance, although even n-alkanes are present in greater quantities in the interstadial, indicating an increasing terrestrial contribution in the Holocene. Ongoing deuterium isotope measurements of the n-alkanes will give independent evidence for palaeohydrological changes and can be compared to the other proxy evidence within the same core. Using a combination of nC29 and nC23 (terrestrial and aquatic end-members, respectively), a change in relative humidity (rH) can be qualified. This is based on the idea that terrestrial vegetation is affected by evapotranspiration processes, whereas aquatic vegetation is not (Rach et al., 2014). This data is supported by a high resolution palynological study; the contiguously sampled record demonstrates ecosystem/environmental responses to millennial-scale climatic change and allows for the possible detection of vegetation shifts at the sub-millennial scale. Vegetation aside, the pollen data can further aid in the interpretation of the recorded n-alkanes and isotopic analyses. This data is placed within a chronological framework derived from a high resolution crypto- and

  11. Environment and paleoecology of a 12 ka mid-North American Younger Dryas forest chronicled in tree rings

    Science.gov (United States)

    Panyushkina, Irina P.; Leavitt, Steven W.; Thompson, Todd A.; Schneider, Allan F.; Lange, Todd

    2008-01-01

    Until now, availability of wood from the Younger Dryas abrupt cooling event (YDE) in N. America ca. 12.9 to 11.6 ka has been insufficient to develop high-resolution chronologies for refining our understanding of YDE conditions. Here we present a multi-proxy tree-ring chronology (ring widths, “events” evidenced by microanatomy and macro features, stable isotopes) from a buried black spruce forest in the Great Lakes area (Liverpool East site), spanning 116 yr at ca. 12,000 cal yr BP. During this largely cold and wet period, the proxies convey a coherent and precise forest history including frost events, tilting, drowning and burial in estuarine sands as the Laurentide Ice Sheet deteriorated. In the middle of the period, a short mild interval appears to have launched the final and largest episode of tree recruitment. Ultimately the tops of the trees were sheared off after death, perhaps by wind-driven ice floes, culminating an interval of rising water and sediment deposition around the base of the trees. Although relative influences of the continental ice sheet and local effects from ancestral Lake Michigan are indeterminate, the tree-ring proxies provide important insight into environment and ecology of a N. American YDE boreal forest stand.

  12. A coupled D/18O approach to reconstruct the paleohumidity during the Younger Dryas in the Eifel, Germany

    Science.gov (United States)

    Wüthrich, Lorenz; Hepp, Johannes; Bromm, Tobias; Kathrin Schäfer, Imke; Zech, Jana; Sirocko, Frank; Zech, Michael; Zech, Roland

    2016-04-01

    Leaf waxes, such as long-chain n-alkanes and n-alkanoic acids, and their D/H isotopic composition, are increasingly used in lake, marine and eolian sediments to reconstruct past changes in vegetation, as well as the isotopic composition of precipitation. However, evaporative enrichment of leaf water might compromise such reconstructions, and it remains difficult to quantitatively reconstruct past climate changes. For the present study, we have analyzed samples from the Gemündener Maar, a lake situated in the western Eifel, Germany, for their isotopic composition of n-alkanes (D) and sugars (18O). Combination of both isotopes allows calculating not only the isotopic composition of paleo-precipitation, but also relative humidity (rh), based on reconstructed d-excess of leaf water. Our results suggest that the Younger Dryas was not particularly dry compared to the Alleröd. The onset of the Holocene, on the other hand, seems to have been very dry, except for one humid spell. Only with the transition Preboreal/Boreal, rh increased again.

  13. Carbon isotopes from fossil packrat pellets and elevational movements of Utah agave plants reveal the Younger Dryas cold period in Grand Canyon, Arizona

    Science.gov (United States)

    Cole, Kenneth L.; Arundel, Samantha T.

    2005-09-01

    Carbon isotopes in rodent fecal pellets were measured on packrat (Neotoma spp.) middens from the Grand Canyon, Arizona. The pellet samples reflect the abundance of cold-intolerant C4 and Crassulacean acid metabolism (CAM) plant species relative to the predominant C3 vegetation in the packrat diet. The temporal sequence of isotopic results suggests a temperature decline followed by a sharp increase corresponding to the Bølling/ Allerød Younger Dryas early Holocene sequence. This pattern was then tested using the past distribution of Utah agave (Agave utahensis). Spatial analyses of the range of this temperature-sensitive CAM species demonstrate that its upper elevational limit is controlled by winter minimum temperature. Applying this paleotemperature proxy to the past elevational limits of Utah agave suggests that minimum winter temperatures were ˜8 °C below modern values during the Last Glacial Maximum, 4.5 6.5 °C below modern during the Bølling/Allerød, and 7.5 8.7 °C below modern during the early Younger Dryas. As the Younger Dryas terminated, temperatures warmed ˜4 °C between ca. 11.8 ka and 11.5 ka. These extreme fluctuations in winter minimum temperature have not been generally accepted for terrestrial paleoecological records from the arid southwestern United States, likely because of large statistical uncertainties of older radiocarbon results and reliance on proxies for summer temperatures, which were less affected.

  14. Strong middepth warming and weak radiocarbon imprints in the equatorial Atlantic during Heinrich 1 and Younger Dryas

    Science.gov (United States)

    Weldeab, Syee; Friedrich, Tobias; Timmermann, Axel; Schneider, Ralph R.

    2016-08-01

    We present a benthic foraminiferal multiproxy record of eastern equatorial Atlantic (EEA) middepth water (1295 m) covering the last deglacial. We show that EEA middepth water temperatures were elevated by 3.9 ± 0.5°C and 5.2 ± 1.2°C during Heinrich event 1 (H1) and Younger Dryas (YD), respectively. The radiocarbon content of the EEA middepth during H1 and YD is relatively low and comparable to the values of the pre-H1 episode and Bølling-Allerød, respectively. A transient Earth system model simulation, which mimics the observed deglacial Atlantic Meridional Overturning Circulation (AMOC) history, qualitatively reproduces the major features of the EEA proxy records. The simulation results suggest that fresh water-induced weakening of the AMOC leads to a vertical shift of the horizon of Southern Ocean-sourced water and a stronger influence of EEA sea surface temperatures via mixing. Our findings reaffirm the lack of a distinctive signature of radiocarbon depletion and therefore do not support the notion of interhemispheric exchanges of strongly radiocarbon-depleted middepth water across the tropical Atlantic during H1 and YD. Our temperature reconstruction presents a critical zonal and water depth extension of existing tropical Atlantic data and documents a large-scale and basin-wide warming across the thermocline and middepth of the tropical Atlantic during H1 and YD. Significant difference in the timing and pace of H1 middepth warming between tropical Atlantic and North Atlantic likely points to a limited role of the tropical Atlantic middepth warming in the rapid heat buildup in the North Atlantic middepth.

  15. Wildfire and abrupt ecosystem disruption on California's Northern Channel Islands at the Ållerød-Younger Dryas boundary (13.0-12.9 ka)

    Science.gov (United States)

    Kennett, D. J.; Kennett, J. P.; West, G. J.; Erlandson, J. M.; Johnson, J. R.; Hendy, I. L.; West, A.; Culleton, B. J.; Jones, T. L.; Stafford, Thomas W., Jr.

    2008-12-01

    Sedimentary records from California's Northern Channel Islands and the adjacent Santa Barbara Basin (SBB) indicate intense regional biomass burning (wildfire) at the Ållerød-Younger Dryas boundary (˜13.0-12.9 ka) (All age ranges in this paper are expressed in thousands of calendar years before present [ka]. Radiocarbon ages will be identified and clearly marked " 14C years".). Multiproxy records in SBB Ocean Drilling Project (ODP) Site 893 indicate that these wildfires coincided with the onset of regional cooling and an abrupt vegetational shift from closed montane forest to more open habitats. Abrupt ecosystem disruption is evident on the Northern Channel Islands at the Ållerød-Younger Dryas boundary with the onset of biomass burning and resulting mass sediment wasting of the landscape. These wildfires coincide with the extinction of Mammuthus exilis [pygmy mammoth]. The earliest evidence for human presence on these islands at 13.1-12.9 ka (˜11,000-10,900 14C years) is followed by an apparent 600-800 year gap in the archaeological record, which is followed by indications of a larger-scale colonization after 12.2 ka. Although a number of processes could have contributed to a post 18 ka decline in M. exilis populations (e.g., reduction of habitat due to sea-level rise and human exploitation of limited insular populations), we argue that the ultimate demise of M. exilis was more likely a result of continental scale ecosystem disruption that registered across North America at the onset of the Younger Dryas cooling episode, contemporaneous with the extinction of other megafaunal taxa. Evidence for ecosystem disruption at 13-12.9 ka on these offshore islands is consistent with the Younger Dryas boundary cosmic impact hypothesis [Firestone, R.B., West, A., Kennett, J.P., Becker, L., Bunch, T.E., Revay, Z.S., Schultz, P.H., Belgya, T., Kennett, D.J., Erlandson, J.M., Dickenson, O.J., Goodyear, A.A., Harris, R.S., Howard, G.A., Kloosterman, J.B., Lechler, P

  16. Hydrological Influence on the Dead Carbon Fraction in a Tropical Speleothem During the Younger Dryas and the Last Millennium

    Science.gov (United States)

    Griffiths, M. L.; Hua, Q.; Drysdale, R.; Bajo, P.; Jenkins, D.; Hellstrom, J. C.; Johnson, K. R.; Gagan, M. K.; Zhao, J. X.

    2015-12-01

    The number of paleoclimate records derived from speleothems has increased significantly in recent years. In addition, speleothems have been used for calibration of the radiocarbon timescale beyond the range of the tree-ring record. One critical issue for reliable speleothem-based radiocarbon calibration and 14C dating of speleothems is constraining the temporal variations in the radioactively dead carbon (i.e. dead carbon fraction (DCF)) that is incorporated into this archive and to determine the potential mechanisms driving such changes. While some studies have shown insignificant variations in DCF through time and highlighted the potential utility of speleothems to extend/improve the radiocarbon calibration curve, others have reported significant temporal variability in speleothem DCF associated with changes in cave recharge. To further assess the potential hydrological control on speleothem radiocarbon variability, we constructed a new high-resolution DCF record from a speleothem from Flores, Indonesia for two different time periods, the Younger Dryas (YD) chronozone and the Last Millennium. A total of thirty-four 14C analyses (twenty for the YD and fourteen for the Last Millennium) were conducted on pieces of calcite extracted from stalagmite LR06-B1, which was well-dated by ~90 U-Th ages. To better characterize the paleoclimate and environmental changes, high-resolution stable-isotope (δ18O, δ13C) and trace-element (Mg/Ca, Sr/Ca) measurements were also conducted along the same sections of stalagmite. Broad comparison of the DCF record with the hydrologically-controlled proxy data suggests that increases in rainfall were matched by DCF increases. In line with a previous interpretation of DCF variability for the same specimen, but during the time interval 2.4-2.8 cal kyr BP and the post-bomb period, we interpret the DCF during the YD and the Last Millennium to have been primarily controlled by limestone dissolution associated with changes in open- versus

  17. A detailed comparison of Asian Monsoon intensity and Greenland temperature during the Allerød and Younger Dryas events

    Science.gov (United States)

    Liu, Dianbing; Wang, Yongjin; Cheng, Hai; Edwards, R. Lawrence; Kong, Xinggong; Wang, Xianfeng; Wu, Jiangying; Chen, Shitao

    2008-08-01

    An annual layer-counted and 230Th-dated stalagmite oxygen isotope record from Qingtian Cave in Hubei province, central China, provides an Asian Monsoon (AM) history across the Allerød to Younger Dryas (YD) transition, with an average 2.5-year resolution. Seasonal δ18O profiles indicate that the calcite δ18O is a sensitive proxy for AM changes, and the close similarity between the Qingtian and other cave records from eastern China suggests a large-scale regional coherence of monsoonal precipitation δ18O variations associated with the temperature changes in high-northern latitudes. The annually-resolved chronology with a U-Th age uncertainty of less than 100 yr defines the timing, duration and transition of the early Allerød, the intra-Allerød cold period (IACP), the late Allerød, and the start of the YD. The 160-yr-long IACP, with two brief reversals, is clearly shown in both δ18O and lamina thickness records. The early and late Allerød, separated by the IACP, are characterized by several decadal to centennial cycles of δ18O variations, each punctuated by sub-cycles. These decadal to centennial monsoon variations correlate with the Greenland temperature changes, supporting a model simulation that the decadal North Atlantic Oscillation (NAO) and North Pacific Oscillation (NPO) are coupled via atmospheric circulation under glacial boundary conditions, perhaps affecting tropical/subtropical monsoon changes. However, the monsoon transition between the late Allerød and YD lasted 380 yr, longer than the analogous Greenland temperature shift by at least 130 yr [Stuiver, M., Grootes, P.M., GISP2 oxygen isotope ratios. Quat. Res. 53 (2000) 277-284]. This implicates other links besides the direct link between Greenland and the AM, which is now well documented. One possibility is the influence by Southern Hemisphere climate via cross-equatorial air flow [An, Z.S., The history and variability of the East Asian paleomonsoon climate. Quat. Sci. Rev. 19 (2000) 171-187].

  18. Differential proxy responses to late Allerød and early Younger Dryas climatic change recorded in varved sediments of the Trzechowskie palaeolake in Northern Poland

    Science.gov (United States)

    Słowiński, Michał; Zawiska, Izabela; Ott, Florian; Noryśkiewicz, Agnieszka M.; Plessen, Birgit; Apolinarska, Karina; Rzodkiewicz, Monika; Michczyńska, Danuta J.; Wulf, Sabine; Skubała, Piotr; Kordowski, Jarosław; Błaszkiewicz, Mirosław; Brauer, Achim

    2017-02-01

    High-resolution biological proxies (pollen, macrofossils, Cladocera and diatoms), geochemical data (μ-XRF element scans, TOC, C/N ratios, δ18Ocarb and δ13Corg values) and a robust chronology based on varve counting, AMS 14C dating and tephrochronology were applied to reconstruct lake system responses to rapid climatic and environmental changes of the Trzechowskie palaeolake (TRZ; Northern Poland) during the late Allerød - Younger Dryas (YD) transition. Palaeoecological and geochemical data at 5-15 years temporal resolution allowed tracing the dynamics of short-term shifts of the ecosystem triggered by abrupt climate change. The robust age control together with the high-resolution sampling allowed the detection of leads and lags between different proxies to the climate shift at the Allerød-Younger Dryas transition. Our results indicate (1) a water level decrease and an increase in wind activities during the late Allerød and the Allerød-YD transition, which caused intensified erosion in the catchment, (2) a two-decades delayed vegetation response in comparison to the lake depositional system. Comparison with the Lake Meerfelder Maar record revealed slightly different vegetation responses of the Trzechowskie palaeolake at the YD onset.

  19. Behaviour of the lake district ice lobe of the Scandinavian ice sheet during the younger dryas chronozone (ca. 12 800 - 11 500 years ago)

    Energy Technology Data Exchange (ETDEWEB)

    Lunkka, J.P.; Erikkilae, A. [Oulu Univ. (Finland)

    2012-04-15

    It is highly relevant to picture the conditions that prevailed under and in front of the ice sheets as they were stationary or in equilibrium for many hundreds of years. This knowledge is particularly relevant when planning to dispose of spent nuclear fuel in a repository underground. For estimating what kind of conditions might exist at the ice margin basic knowledge is needed from the palaeoice sheets that remained stationary for long periods of time. During Younder Dryas Stadial (c. 12 800 - 11 500 years ago) glaciers remained stationary or advanced worldwide as a result of climate cooling. The major end moraine complexes that run around Fennoscandia, Russian Karelia and the Kola Peninsula were deposited at that time and mark the former Younger Dryas ice margin. It this work the palaeoenvironments have been reconstructed in order to reveal the conditions that existed for more than 1000 years in the area where the former Lake District Ice Lobe of the Scandinavian Ice Sheet was in the Salpausselkae zone in southern Finland. Work was carried out using GIS-based reconstruction tools, sedimentological and geophysical (ground penetrating radar) methods. In addition, a detailed palaeoenvironmental reconstruction was produced for the Kylaeniemi area which forms a part of the Salpausselkae II end moraine. The GIS-based reconstructions clearly indicate that the ice grounding line of the Lake District Ice Lobe was standing in shallow water depth in the Baltic Ice Lake. The water depth in front of Salpausselkae I, which marks the ice margin at c. 12 500 years ago was mainly between 20-40 metres. When the ice margin was in Salpausselkae II at around 11 700 years ago the water depth in front of the ice margin was on average less than 20 metres. Although the surface profile of ice was not possible to calculate subgalcial and ice frontal landforms indicate that subgalcial tunnel systems were responsible for releasing melt water and sediment to the ice margin throughout the

  20. Climate Reconstructions of the Younger Dryas: An ELA Model Investigating Variability in ELA Depressions, Temperature, and Precipitation Changes for the Graubϋnden Alps

    Science.gov (United States)

    Keeler, D. G.; Rupper, S.; Schaefer, J. M.; Finkel, R. C.

    2015-12-01

    The high sensitivity of mountain glaciers to even small perturbations in climate, combined with a near global distribution, make alpine glaciers an important target for terrestrial paleoclimate reconstructions. The geomorphic remnant of past glaciers can yield important insights into past climate, particularly in regions where other methods of reconstruction are not possible. The quantitative conversion of these changes in geomorphology to a climate signal, however, presents a significant challenge. A particular need exists for a versatile climate reconstruction method applicable to diverse glacierized regions around the globe. Because the glacier equilibrium line altitude (ELA) provides a more explicit comparison of climate than properties such as glacier length or area, ELA methods lend themselves well to such a need, and allow for a more direct investigation of the primary drivers of mountain glaciations during specific events. Here, we present an ELA model for quantifying changes in climate based on changes in glacier extent, while accounting for differences in glacier width, glacier shape, bed topography, ice thickness, and glacier length. The model furthermore provides bounds on the ΔELA using Monte Carlo simulations. These methods are validated using published mass balances and ELA measurements from 4 modern glaciers in the European Alps. We then use this ELA model, combined with a surface mass and energy balance model, to estimate the changes in temperature/precipitation between the Younger Dryas (constrained by 10Be surface exposure ages) and the present day for three glacier systems in the Graubϋnden Alps. Our results indicate an ELA depression in this area of 257 m ±45 m during the Younger Dryas (YD) relative to today. This corresponds to a 1.3 °C ±0.36 °C decrease in temperature or a 156% ±30% increase in precipitation relative to today. These results indicate the likelihood of a predominantly temperature-driven change rather than a strong

  1. Tree-ring records of near-Younger Dryas time in central North America - Preliminary results from the Lincoln quarry site, central Illinois, USA

    Science.gov (United States)

    Panyushkina, Irina P.; Leavitt, Steven W.; Wiedenhoeft, A.; Noggle, S.; Curry, B.; Grimm, E.

    2004-01-01

    The abrupt millennial-scale changes associated with the Younger Dryas (YD) event ("chronozone") near the dawn of the Holocene are at least hemispheric, if not global, in extent. Evidence for the YD cold excursion is abundant in Europe but fairly meager in central North America. We are engaged in an investigation of high-resolution environmental changes in mid-North America over several millennia (about 10,000 to 14,000 BP) during the Late Glacial-Early Holocene transition, including the YD interval. Several sites containing logs or stumps have been identified and we are in the process of initial sampling or re-sampling them for this project. Here, we report on a site in central Illinois containing a deposit of logs initially thought to be of YD age preserved in alluvial sands. The assemblage of wood represents hardwood (angiosperm) trees, and the ring-width characteristics are favorable to developing formal tree-ring chronologies. However, 4 new radiocarbon dates indicate deposition of wood may have taken place over at least 8000 14C yr (6000-14,000 BP). This complicates the effort to develop a single floating chronology of several hundred years at this site, but it may provide wood from a restricted region over a long period of time from which to develop a sequence of floating chronologies, the timing of deposition and preservation of which could be related to paleoclimatic events and conditions.

  2. Younger Dryas and Holocene oceanography of the western Labrador Sea region based on foraminifera and sediment proxies from Placentia Bay, Newfoundland

    Science.gov (United States)

    Sheldon, Christina; Pearce, Christof; Seidenkrantz, Marit-Solveig; Kuijpers, Antoon; Reynisson, Njáll F.; Zilmer Christensen, Eva; Juncker Hansen, Mette

    2014-05-01

    Benthic foraminiferal assemblages and geochemical analyses from three marine sediment cores from Placentia Bay on the southwest coast of Newfoundland captured the evolving surface and subsurface environment of the eastern Labrador Sea during the late glacial and Holocene. The area, which is today located in the boundary zone between the Arctic Labrador current and the warm Gulf Stream in the eastern margin of the Labrador Sea was during the early part of the Younger Dryas (13.0-12.3 cal. kyr BP) dominated by cold, Arctic conditions and heavy sea-ice cover linked to a strong Polar Water component of the Inner Labrador Current. In the later part of the Younger Dryas (12.3-11.5 kyr BP) the influence of the Labrador Current (LC) became less pronounced resulting in more unstable conditions with varying sea-ice cover and increased influence of Gulf Stream water, presumably linked to an increased strength of the Atlantic Meridional Overturning Circulation (AMOC). The earliest Holocene (11.5-10.4 kyr BP) saw slightly warmer subsurface conditions in Placentia Bay and increased productivity, presumably caused by a decreased southward transport of Polar Water via the LC. The onset of a strong AMOC caused the northward movement of the frontal zone between the Subpolar Gyre and the North Atlantic Subtropical Gyre in the western North Atlantic region to closer proximity to the southern coast of Newfoundland compared to previously. From ca. 10.4-9.65 kyr BP increased bottom-current speeds and the presence of species often found in connection to oceanic fronts, suggest a further strengthening of the AMOC causing inflow of Atlantic-source water into Placentia Bay. This tendency was further strengthened at 9.65-7.3 kyr BP, which saw a relatively strong inflow of Atlantic-source Gulf Stream water into Placentia Bay, evidenced by high frequencies of Cassidulina neoteretis. This inflow of Atlantic was however temporarily halted around 8.2 kyr BP, when a short-lived, extreme peak in

  3. Subglacial hydrology of the lake district ice lobe during the Younger Dryas (ca. 12 500 - 11 600 years ago) in the Kylaeniemi area, SE Finland

    Energy Technology Data Exchange (ETDEWEB)

    Lunkka, J. P.; Moisio, K.; Vainio, A. [Univ. of Oulu (Finland)

    2013-07-15

    It is essential to gain knowledge on the subglacial hydrological conditions at the glacier bed / bedrock interface when assessing how bedrock fracture zones affect subglacial melt water flow and in which subglacial zones pressurized and oxygen-rich melt water penetrates into the bedrock fracture systems. In the warm-based glacier zones, a part of subglacial melt water will penetrate deep into the fracture systems although the major part of melt water is drained to and beyond the ice margin via subglacial tunnel networks especially in the areas where ice is flowing on the crystalline bedrock. During the last deglaciation phase of the former Scandinavian Ice Sheet, glaciofluvial accumulations were deposited and these sediment accumulations are highly important when picturing the subglacial hydrology of different ice streams during deglaciation in the crystalline bedrock area. The aim of the present work was to map the bedrock fracture zones in the Kylaeniemi area and to shed light on the subglacial hydrology of the Scandinavian Ice Sheet's Lake District Ice Stream that occupied the Kylaeniemi area during the Younger Dryas between ca. 12 500 - 11 600 years ago. The special emphasis within this general aim was to study the relationship between bedrock fracture zones and the routes of subglacial drainage paths. The methods used to map and study bedrock fracture zones and subglacial drainage paths included remotes sensing methods, field observations, ground penetrating radar (GPR) investigations and GIS-based reconstructions. Conventional geological field methods aided by the GPR-method were also used to map bedrock exposures and their structures and to define the type of glaciofluvial sediments and glaciofluvial landform associations. Two main fracture zone sets occur in the study area. The most prominent bedrock fracture zone set trends NW-SE while the other, less prominent fracture zone set is aligned in NE-SW direction. The majority of the minor joint sets in

  4. Biomarker Records of Lake Albano (central Italy) and Lake Constance (southern Germany)- Implications for environmental change in the Holocene and Younger Dryas

    Science.gov (United States)

    Hanisch, S.; Schwalb, A.; Ariztegui, D.; Wessels, M.; Puettmann, W.

    2003-12-01

    Steroids, triterpenoids and n-alkanes from a 13 m Holocene sediment core from Lake Albano and a 7 m Late Pleistocene/Holocene core from Lake Constance (13,000 to 650 years BP) as well as pigments, pollen and stable isotopes from benthic ostracodes, are used to reconstruct climatic changes and human impact on the lake systems and their catchments. Dinosterol, isoarborinol, hopanoids, and tetrahymanol in Lake Albano sediments indicate changes in the biological assemblages and enhanced lake mixing and thus stronger wind activity at around 6,500 and 3,800 years BP. A development from forest to a more open landscape in the Lake Albano catchment from 5,000 years BP is suggested by a decrease of n-alkanes derived from deciduous trees (C27 and C29). N-alkanes, friedelin and amyrenones show a close correspondence with the percentage of broadleaf-tree pollen, indicating deforestation after 5,000 and 6,500 years BP,. High concentrations of land-plant derived β -sitosterol in Lake Constance sediments during the Younger Dryas indicate erosive input due to sparse vegetation. The increase of β -sitosterol after 7,000 years BP suggests terrigenous input as a result of enhanced precipitation. Dinosterol distribution traces a period of high productivity between 11,600 and 7,000 years BP. Tetrahymanol, a biomarker for ciliates and possibly an indicator for water column stratification, shows relatively high concentrations at approximately 9,000 years BP. This coincides with a 4 ‰ shift to more negative values of δ 13C in the ostracode L. mirabilis, suggesting hydromechanic changes in Lake Constance.

  5. Climate Reconstructions for the Younger Dryas in Graubünden, Swiss Alps: Using Glacier Geometry and Hypsometry to Estimate Equilibrium Line Altitude

    Science.gov (United States)

    Keeler, D. G.; Rupper, S.; Schaefer, J. M.; Finkel, R. C.

    2014-12-01

    Mountain glaciers serve as important paleoclimate records due to the direct physical link between glacier extent and climate. The high sensitivity of mountain glaciers to even small perturbations in the climate has the potential to provide very detailed records of regional glacier and climate histories. Recent progress in age determination techniques such as surface exposure dating has greatly improved the temporal precision of glacial records. The conversion of changes in glacier geometries to a climate signal, however, remains a significant challenge. A particular need exists for a versatile method easily applicable to diverse regions and conditions around the globe. Because the equilibrium line altitude (ELA) provides a more explicit comparison of climate than properties such as glacier length or area, ELA methods lend themselves well to such a need, and allow for a more direct investigation of the primary drivers of mountain glaciations during specific events. Here we present a new, robust ELA model for quantifying changes in climate directly from glacier geometry. The model derives from a linear flow model based on Glen's Flow law while fully accounting for glacier hypsometry. As a preliminary application, we combined our modeled ELA reconstructions with a new 10Be chronology of late glacial culminations in Graubünden in the Swiss Alps. These glacier culminations occurred during the Egesen Stadial, which has been correlated to the Younger Dryas (YD) interval. Results for two related glacier systems in Graubünden reveal an ELA depression of 365-401 m (depending on the moraines chosen) during the Egesen stage/YD compared to the modern ELA. This agrees well both with established estimates for ELA depressions in the region and an additional application performed using our model and previously determined ages on the nearby Lagrev Glacier (a 370 m ELA depression). We then reconstruct the temperature and precipitation changes required to explain the ELA changes for

  6. Enhanced sea-ice export from the Arctic to the GIN seas during the Younger Dryas: A "Canadian" source from radiogenic isotope signatures

    Science.gov (United States)

    Hillaire-Marcel, C.; Maccali, J.; Not, C.; Poirier, A.

    2012-04-01

    The Younger Dryas (YD) cooling event and the related slowing of the Atlantic Meridional Overturning Circulation (AMOC) have been linked to a large array of processes. The most widely supported causal mechanism involves an influx of freshwater into the North Atlantic Ocean linked to a partial drainage of glacial Lake Agassiz. Recently, a northward drainage route, through the Mackenzie River outlet into the Arctic Ocean, has been suggested from land-based studies [Murton et al., Nature 464, 740-743]. Sedimentological and geochemical analysis of cores raised from Lomonosov Ridge and the Fram Strait area, yield relatively robust evidence for enhanced ice-rafting deposition -IRD- (with a 5-fold increase -) during the critical interval. At Lomonosov, the corresponding sedimentary layer (from ca. 13 to 12 ka) is marked by a pulse of detrital carbonates in the silt to sand fractions, with approximately equal amounts of calcite and dolomite, pointing towards an Arctic Canadian sediment source area [Not & Hillaire-Marcel, Nature Communication, Jan. 31, 2012]. The layer also depicts a 5 fold increase 230Th-excess, which we link to an enhanced flux of scavenging particles. At both sites, the geochemical signatures of the YD-layer, based on elemental (Zr/Al) and isotopic (Sr, Nd and Pb) data on bulk sediments and residues ensuing from the removal of exchangeable fractions (Zr/Al, Nd, Pb, Sr), are used to identify detrital sediment source areas. Whereas three major source areas variably contributed to IRD during the MIS 3-Present interval (i.e., the Russian, Canadian and Greenland margins), the YD interval singles out by strongelemental and isotopic excursions, notably a peak in radiogenic Sr, indicating prominent supplies from the Canadian end-member. This suggests enhanced sea-ice production and drifting along the BeaufordGyre, then the Trans-Polar Drift. A major drainage event along the Mackenzie outlet area, as proposed in the above reference,would be a suitable trigger for

  7. Beringian Megafaunal Extinctions at ~37 ka B.P.: Do Micrometeorites Embedded in Fossil Tusks and Skulls Indicate an Extraterrestial Precursor to the Younger Dryas Event?

    Science.gov (United States)

    Hagstrum, J. T.; Firestone, R. B.; West, A.

    2009-12-01

    Studies of Late Pleistocene megafaunal fossils and their ancient DNA from Beringia (eastern Siberia, Alaska, and the emerged Bering Strait) indicate sharp declines in steppe bison population diversity and horse body size, extinction of the Alaskan wild ass, and local extinctions of brown bear and woolly mammoth genetic lines beginning at about 37 ka B.P. Beringia is also well known for its remarkably preserved Late Pleistocene frozen animal mummies. 14C ages of these mummies are bimodally distributed, having peaks coincident with the earlier ~37 ka B.P., and ~13 ka B.P. Younger Dryas, onset extinction events. Associated with the ~37 ka B.P. event are, for example, the Berezovka mammoth, headless Selerikan horse, steppe bison “Blue Babe”, and baby mammoths “Dima” and “Lyuba”. Analyses of these and other mummies indicate that they died instantly, in mostly healthy condition, with gut contents and high fat reserves indicative of a late summer to autumn season. An assortment of uneaten limbs and other body parts from a variety of species have also been found. Uniformitarian death scenarios inadequately account for the lack of evidence of normal predation and scavenging. Extensive internal injuries (e.g. large bone fractures, hemorrhaging) and apparent rapid burial of the mummies also indicate that something truly unusual happened at the time of these extinction events. We have discovered what appear to be micrometeorites embedded in seven Alaskan mammoth tusks and a Siberian bison skull acquired from commercial sources. 14C ages for five of these fossils have a weighted mean age of 33 ± 2 ka B.P. Laser ablation ICP-MS and XRF analyses of the particles indicate high Fe contents with compositions enriched in Ni and depleted in Ti, similar to Fe meteorites and unlike any natural terrestrial sources. Microprobe analyses of a Fe-Ni sulfide grain from tusk 2 also show that it contains between 3 and 20 weight percent Ni. SEM images and XRF analyses of a bison

  8. Reply to comment by E. Bard et al. on "Younger Dryas sea level and meltwater pulse 1B recorded in Barbados reef crest coral Acropora palmata" by N. A. Abdul et al.

    Science.gov (United States)

    Mortlock, Richard A.; Abdul, Nicole A.; Wright, James D.; Fairbanks, Richard G.

    2016-12-01

    Abdul et al. (2016) presented a detailed record of sea level at Barbados (13.9-9 kyr B.P.) tightly constraining the timing and amplitude during the Younger Dryas and Meltwater Pulse 1B (MWP-1B) based on U-Th dated reef crest coral species Acropora palmata. The Younger Dryas slow stand and the large (14 m) rapid sea level jump are not resolved in the Tahiti record. Tahiti sea level estimates are remarkably close to the Barbados sea level curve between 13.9 and 11.6 kyr but fall below the Barbados sea level curve for a few thousand years following MWP-1B. By 9 kyr the Tahiti sea level estimates again converge with the Barbados sea level curve. Abdul et al. (2016) concluded that Tahiti reefs at the core sites did not keep up with intervals of rapidly rising sea level during MWP-1B. We counter Bard et al. (2016) by showing (1) that there is no evidence for a hypothetical fault in Oistins Bay affecting one of the Barbados coring locations, (2) that the authors confuse the rare occurrences of A. palmata at depths >5 m with the "thickets" of A. palmata fronds representing the reef-crest facies, and (3) that uncertainties in depth habitat proxies largely account for differences in Barbados and Tahiti sea level differences curves with A. palmata providing the most faithful proxy. Given the range in Tahiti paleodepth uncertainties at the cored sites, the most parsimonious explanation remains that Tahiti coralgal ridges did not keep up with the sea level rise of MWP-1B.

  9. Abrupt sea surface pH change at the end of the Younger Dryas in the central sub-equatorial Pacific inferred from boron isotope abundance in corals (Porites

    Directory of Open Access Journals (Sweden)

    A. Juillet-Leclerc

    2010-08-01

    Full Text Available The "δ11B-pH" technique was applied to modern and ancient corals Porites from the sub-equatorial Pacific areas (Tahiti and Marquesas spanning a time interval from 0 to 20.720 calendar years to determine the amplitude of pH changes between the Last Glacial Period and the Holocene. Boron isotopes were measured by Multi-Collector – Inductively Coupled Plasma Mass Spectrometry (MC-ICPMS with an external reproducibility of 0.25‰, allowing a precision of about ±0.03 pH-units for pH values between 8 and 8.3. The boron concentration [B] and isotopic composition of modern samples indicate that the temperature strongly controls the partition coefficient KD for different aragonite species. Modern coral δ11B values and the reconstructed sea surface pH values for different Pacific areas match the measured pH expressed on the seawater scale and confirm the calculation parameters that were previously determined by laboratory calibration exercises. Most ancient sea surface pH reconstructions near Marquesas are higher than modern values. These values range between 8.19 and 8.27 for the Holocene and reached 8.30 at the end of the last glacial period (20.7 kyr BP. At the end of the Younger Dryas (11.50±0.1 kyr BP, the central sub-equatorial Pacific experienced a dramatic drop of up to 0.2 pH-units from the average pH of 8.2 before and after this short event. Using the marine carbonate algorithms, we recalculated the aqueous pCO2 to be 440±25 ppmV at around 11.5 kyr BP for corals at Marquesas and ~500 ppmV near Tahiti where it was assumed that pCO2 in the atmosphere was 250 ppmV. Throughout the Holocene, the difference in pCO2 between the ocean and the atmosphere at Marquesas (ΔpCO2 indicates that the surface waters behave as a moderate CO2 sink or source (−53 to 20 ppmV during El Niño-like conditions. By contrast, during the last glacial/interglacial transition, this area was a marked source of CO2 (21 to 92 ppmV for the atmosphere, highlighting

  10. Spatiotemporal patterns of hydrological changes during the onset of the Younger Dryas along a W-E transect in Europe from decadal resolved lacustrine lipid biomarker D/H records

    Science.gov (United States)

    Sachse, Dirk; Aichner, Bernhard; Maas, David; Neugebauer, Ina; Ott, Florian; Slowinski, Michal; Wulf, Sabine; Brauer, Achim

    2016-04-01

    To better understand mechanisms and feedbacks of hydrological changes during abrupt climatic changes, such as the onset of the Younger Dryas (YD) cold period, we applied biomarker based paleohydrological proxies to three well dated, high-resolution lacustrine sediment profiles along a 900km W-E transect from Western Germany to Eastern Poland. Here we present biomarker hydrogen isotope records (δD values) from terrestrial and aquatic sources from three sites (Meerfelder Maar, western Germany [MFM]; Rehwiese, eastern Germany [RW]; Trzechowskie, central Poland [TRZ]) that contain annually laminated sediments and common tephra layers, allowing the identification of leads and lags in the response of the hydrological cycle to YD cooling on decadal timescales. We observed a decrease in biomarker δD values 170 and 100 years before the biostratigraphically defined onset of the YD at 12,679 in western (MFM) and eastern Germany (RW), respectively. These changes coincide with the onset of Greenland Stadial 1 in the NGRIP icecore at 12,846 years BP and imply a common climatic forcing, likely cooling. In eastern Poland however, at TRZ biomarker δD values start to decrease only at the YD onset. Further, we observed that the onset of aridification at all three sites coincided with the onset of the YD. A decrease in the magnitude of changes in biomarker δD values and aridification from W to E suggests a more gradual and less strong aridification in eastern Europe. Our results suggest that hydrological changes at the onset of the YD were strongest and most abrupt in western Europe, where a substantial increase in aridity occurred over just 80 years, resulting in widespread environmental changes [1]. These differences in magnitude and the distinct temporal succession could be related to the influence of the Fennoscandian ice sheets and/or the Siberian High on atmospheric circulation in eastern Europe. [1] Rach O, Brauer A, Wilkes H, Sachse D. Delayed hydrological response to

  11. DYNAMICAL SIMULATION ON TIDAL CURRENT FIELD IN ANCIENT YELLOW SEA DURING YOUNGER DRYAS EPISODE%新仙女木期古黄海潮流场的数值模拟

    Institute of Scientific and Technical Information of China (English)

    韩喜彬; 史经昊; 李家彪; 李广雪

    2009-01-01

    During Younger Dryas episode (12. 9 ~11. 6 cal. Ka), the sea level oscillated at about - 66 m depth contour in the continental shelf seas in eastern China and the seawater got into the south of the present North Yellow Sea,so Yellow Sea became a long narrow channel gulf. To simulate the tidal current of this special gulf, Environmental Fluid Dynamics Computer Code is used in this paper. The calculation combines curvilinear orthogonal coordinates in the horizontal direction with Sigma mapping coordinates in the vertical direction, and it uses a method which transforms a problem from three-dimension into two-dimension. The results show that the tidal current was still very strong in Yellow Sea during Younger Dryas episode, entering the special gulf along the right side entrance. From both shallow sides to deep centre, rotating flow changes reciprocating flow. Under the effect of reciprocating flow, the floor is eroded and the mud and sand are carried away. Progressive wave turns into rotating wave and two ateliotic amphidromic points appear on the western side of the gulf after tidal wave coming into Yellow Sea. At the same time, tidal residual current flows to southeast and east with relatively great velocity at the west and interior gulf and it becomes weakly near the entrance. The current may carry the bottom sediments and discharge them to the present mud sediment zone in north East China Sea. But at eastern Yellow Sea the tidal residual current flows to north and forms an anticlockwise circulation at centre of the eastern gulf which is corresponding to the eddy mud zone in Southeast Yellow Sea (Heishan mud zone). The anticlockwise circulation captures suspended sediment and may gestate the present mud sediment zone. The extension direction of tidal sand ridges and the size composition of the tidal current sand in eastern South Yellow Sea have a close relationship with the tidal current field of the ancient Yellow Sea, so the less fluctuating sea level changing

  12. North Pacific-wide spreading of isotopically heavy nitrogen from intensified denitrification during the Bølling/Allerød and post-younger dryas periods: evidence from the Western Pacific

    Directory of Open Access Journals (Sweden)

    S. J. Kao

    2008-03-01

    Full Text Available Sedimentary δ15N record for the past 30 ka buried in the Okinawa Trough in the western North Pacific mimicking the pattern from the Eastern Tropical North Pacific (ETNP, but the values (4.4–5.8‰ and the amplitude of the variation were much smaller than those (9–17‰ of the previous site. All but three values in the record were lower than the mean δ15N (5.6‰ of nitrate in the upper 800 m of the Kuroshio water suggesting additional inputs of isotopically light nitrogen from N2-fixation. The peak values of δ15N occurred during the Bølling/Allerød period and the warming period right after the Younger Dryas, synchronous to those found in the Eastern North Pacific. It is highly probable the high δ15N values are originated from the influence of the intensified denitrification in the ETNP during the warming periods. These new data represent the sedimentary record most distant from the intensive denitrifying zone in the ETNP and may serve as critical constraints to better quantify the nitrogen budget in the last climate cycle.

  13. Younger Dryas Event and Cold Events in Early-Mid Holocene: Record from the sediment of Erhai Lake%新仙女木事件及全新世早中期降温事件——来自洱海湖泊沉积的记录

    Institute of Scientific and Technical Information of China (English)

    周静; 王苏民; 杨桂山

    2007-01-01

    Three cold events (the Younger Dryas, 9.4 ka cal BP, 5.8 ka cal BP) since the 13 ka cal BP in Erhai (EH) Lake catchment, Yunnan Province, were analyzed using the Total Organic Carbon (TOC) series of the EH core. By comparison of the EH core, Qinghai Lake core and Guliya ice core, differences of these cold events were determined. Erhai Lake's responses to the global cold events were lagged in time and weakened in intensity in comparison with Qinghai Lake's. The latitude location of Erhai Lake and the obstruction of Tibetan Plateau may in part explain the differences. However, the remarkable cold event of 8.2 ka cal BP in the Guliya ice core was absent in the records of Erhai Lake and Qinghai Lake. Power spectrum analysis of the TOC proxy series shows that there were three kinds of millennial cycles, i.e. 5 ka, 2.3 ka, and 1.5 ka, in climate changes in Erhai Lake, which reveal the responses of climate to suborbit cycles.

  14. A Younger Dryas re-advance of local glaciers in north Greenland

    DEFF Research Database (Denmark)

    Larsen, Nicolaj K.; Funder, Svend; Linge, Henriette

    2016-01-01

    in front of local glaciers on a 50 km stretch along the north coast of Greenland, facing the Arctic Ocean. Ten ages range from 11.6 ± 0.5 to 27.2 ± 0.9 ka with a mean age of 12.5 ± 0.7 ka after exclusion of two outliers. We consider this to be a minimum age for the abandonment of the moraines. The ages...... of the glaciers in northernmost Greenland as a function of their remoteness from the Atlantic Meridional Overturning Circulation (AMOC), which in other areas has been held responsible for modifying the YD drop in temperatures....

  15. Evidence from Central Mexico Supporting the Younger Dryas Extraterrestrial Impact Hypothesis

    Science.gov (United States)

    2012-03-05

    Steven M. Stanley, University of Hawaii , Honolulu, HI, and approved January 31, 2012 (received for review July 13, 2011) We report the discovery in...second largest lake in Mexico, located at high elevation of 1,820 m in the northern part of the state of Michoacán within the tectonically active...and Fe, concentrated in the rind. They reach a significant peak of approximately 680∕kg at 2.75 m within the YDB layer. Above 2.75 m, the CSp persist

  16. A Late Younger Dryas-Early Holocene tephrostratigraphy for Fosen, Central Norway

    DEFF Research Database (Denmark)

    Lind, Ewa M.; Wastegard, Stefan; Larsen, Jeppe J.

    2013-01-01

    a tephrostratigraphy for Fosen peninsula, Central Norway. Both the Vedde Ash ca.12.1 ka BP and the Saksunarvatn Ash approximate to 10.3 ka BP are important isochrones for correlations of Late Quaternary palaeoenvironmental records in the North Atlantic region and have been assigned ages in GICC05. Beside these tephras...

  17. The deglaciaton of the Pyreenes: from the Oldest Dryas to the Little Ice Age

    Science.gov (United States)

    Palacios, David; de Andrés, Nuria; López-Moreno, Juan I.; García-Ruiz, José M.

    2014-05-01

    The main purpose of the paper is to study the deglaciation process, including the retreat of the glaciers and the occurrence of short advances with the deposition of new, relatively recent tills in two head valleys of the central-southern Pyrenees: The Upper Gállego Valley, with the main peak Balaitus (42°46'0' N, 0° 15'0'W, 3151 m), and the Marbore Cirque, at the head of the Cinca Valley, on the north face of the Monte Perdido Peak (42º400' N; 0.5º0'W; 3355 m). The deglaciation process was studied through geomorphological mapping and 36Cl cosmogenic exposure ages obtained from morainic and rock glacier boulders and polished bedrocks. Even though the exact position of the front glacier during the global Last Glacial Maximum is not known, there is evidence that the different ice tongues retreated until headwater positions, causing the subdivision of the main glaciers into various individual glaciers. Two clear climate reversals within the general trend to deglaciation have been detected: First of all, the Oldest Dryas, coinciding with the Heinrich Event 1 (ca 17-15 ka) and, secondly, the Younger Dryas (ca 13-11.7 ka). Between both stadials, the Bølling/Allerød Interstadial (ca 15-13 ka) represented an intense glacial retreat up to the cirque headwalls. During the Bølling/Allerød Interstadial the retreat was very rapid, although the occurrence of a short readvance of small glaciers during the Older Dryas must not be ruled out. The Younger Dryas is represented by a new glacial push with the deposition of distinct types of tills. During these late glacier advances, small glaciers and rock glaciers developed close to the cirque headwalls, and coexisted under the same climatic conditions. After the Younger Dryas, new glacial advances has not been detected until the Little Ice Age, except in the Marbore Cirque, where glacial expansion occurred during the Mid and Late Holocene (5.1 ± 0.1 ka), represented by a large push moraine. A melting phase occurred at

  18. Floodplain environmental change during the younger dryas and holocene: Evidence from the lower kennet valley, south central England

    OpenAIRE

    Collins, PEF; Worsley, P.; Keith-Lucas, DM; Fenwick, IM

    2006-01-01

    Many lowland rivers across northwest Europe exhibit broadly similar behavioural responses to glacial-interglacial transitions and landscape development. Difficulties exist in assessing these, largely because the evidence from many rivers remains limited and fragmentary. Here we address this issue in the context of the river Kennet, a tributary of the Thames, since c. 13,000 cal. BP). Some similarities with other rivers are present, suggesting that regional climatic shifts are important con...

  19. Exposed: younger mothers and breastfeeding.

    Science.gov (United States)

    Noble-Carr, Debbie; Bell, Catherine

    2012-11-01

    This qualitative study, conducted by volunteers from the Australian Capital Territory/Southern New South Wales (ACT/SNSW) Branch of the Australian Breastfeeding Association (ABA), explored the breastfeeding experiences of younger mothers (under the age of 26 years) in the ACT by conducting three focus groups. The study aimed to gain an understanding of how, when and where younger mothers want and need to receive breastfeeding information and support. Younger mothers provided important insights into their breastfeeding experiences, which were often characterised by judgement from health professionals and the wider public. A number of key issues were identified including: breastfeeding is far from a cultural norm in our society and as such the risks of artificial baby milk are not clearly understood by many younger mothers; younger mothers are strongly influenced by their partners, mothers and peers and they rely upon them for breastfeeding information and support. Younger mothers indicated that a number of improvements could be made to the way that breastfeeding information and support is currently provided within the ACT. The findings indicated that younger mothers (and their significant others) would benefit from receiving clear, concise and consistent breastfeeding information early on in their pregnancy, that is positive in tone, not necessarily 'young mum' specific and consistent with a 'less is more' approach. Younger mothers indicated that after the birth of their baby this breastfeeding information needs to be complemented by readily accessible, seamless, respectful support for as long as they need to establish breastfeeding and overcome any breastfeeding challenges. The focus group findings were largely consistent with the existing literature available on younger mothers and breastfeeding and provide valuable insights to all stakeholders responsible for providing breastfeeding information and support to younger mothers.

  20. The presence of the Oldest Dryas in Spanish mountain landscapes

    Science.gov (United States)

    Palacios, David; Andres, Nuria

    2015-04-01

    The important advances in our understanding of the Oldest Dryas (OD) in the evolution of the continental ice caps and the oceanic basin have not yet reached the European mountains, or have only affected a small part of them. In practice, research into the impact of this period on European mountains has focused on the Alps, where the Gschnitz stadial, a glacial re-advance phase, has been clearly differentiated. This is shown in the landscape by families of moraines present in many valleys, above all in small and medium ones, with minimum age 15.9 ka, but which may represent glacial advances of at least a thousand years older. Traces of this same phase are gradually appearing in other European mountains, including some mountains in Spain. The aim of this paper is to emphasise the importance of the Oldest Dryas in the configuration of high mountain landscape in Spain: (Sierra Nevada, Central System and Pyrenees), through the analysis of the latest studies of glacial chronology. In Sierra Nevada, in the SE sector of the Iberian Peninsula, the definitive deglaciation occurred just at the end of the OD, between 15 and 14.5 ka, according to dates obtained from many polished thresholds. There are moraines which obtain dates between 17 and 16 ka, very close to those of the Maximum Ice Extent (MIE), although as there are still only a few of these and because of slope instability they may be morainic boulders from the MIE phase which have been destabilized, disturbed or exhumed, so that more detailed research is required. Nevertheless, it is known for certain that the end of the OD was accompanied by the massive formation of rock glaciers, resting on the polished thresholds mentioned above and with their fronts stabilized at the end of the OD, around 14.5 ka, although their roots remained active until the Holocene. In the Central System, in both Gredos and Guadarrama, the OD was a phase of great advance after almost disappearing after the MIE. During the OD the glaciers

  1. Lung cancer in younger patients

    DEFF Research Database (Denmark)

    Abbasowa, Leda; Madsen, Poul Henning

    2016-01-01

    INTRODUCTION: Lung cancer remains a leading cause of cancer-related death. The incidence increases with age and the occurrence in young patients is relatively low. The clinicopathological features of lung cancer in younger patients have not been fully explored previously. METHODS: To assess the age...... differences in the clinical characteristics of lung cancer, we conducted a retrospective analysis comparing young patients ≤ 65 years of age with an elderly group > 65 years of age. Among 1,232 patients evaluated due to suspicion of lung cancer in our fast-track setting from January-December 2013, 312 newly...... diagnosed lung cancer patients were included. RESULTS: Patients ≤ 65 years had a significantly higher representation of females (p = 0.0021), more frequent familial cancer aggregation (p = 0.028) and a lower incidence of squamous cell carcinoma (p = 0.0133). When excluding pure carcinoid tumours...

  2. Older Siblings Influence Younger Siblings' Motor Development

    Science.gov (United States)

    Berger, Sarah E.; Nuzzo, Katie

    2008-01-01

    Evidence exists for two competing theories about the effects of having an older sibling on development. Previous research has found that having an older sibling has both advantages and disadvantages for younger siblings' development. This study examined whether and how older siblings influenced the onset of their own younger siblings' motor…

  3. Comment on "Younger Dryas sea level and meltwater pulse 1B recorded in Barbados reefal crest coral Acropora palmata" by N. A. Abdul et al.

    Science.gov (United States)

    Bard, Edouard; Hamelin, Bruno; Deschamps, Pierre; Camoin, Gilbert

    2016-12-01

    Based on new U-Th ages of corals drilled offshore Barbados, Abdul et al. (2016) have confirmed the existence of the abrupt stratigraphic feature called meltwater pulse 1B (MWP-1B), which they interpret as being due to a very large and global sea level step change dated at about 11.3 kyr before present (approximately 15 m and equivalent to twice the amount of water stored in the present Greenland ice sheet). This contrasts with the Tahiti record, in which MWP-1B is essentially absent or very small, as Carlson and Clark (2012) and Lambeck et al. (2014) also conclude in their recent reviews of deglacial sea levels at the global scale. However, the evidence provided by Abdul et al. and their main conclusions are not convincing as they are affected by the following three main problems, which may explain the apparent discrepancies: Problem #1/Barbados is located in a subduction zone, which was also active throughout the Late Glacial period. Furthermore, the Barbados cores studied by Abdul et al. were drilled on both sides of the extension of a tectonic feature identified at the southern tip of Barbados (South Point) as underlined by several studies of the Barbados stratigraphy. Problem #2/Fossil samples of Acropora palmata may not be reliable sea level markers during rapid and large sea level rises. Indeed, the asexual reproduction strategy of this species may not be optimal to keep up when the water depth is increasing very rapidly. This may in part explain why the living depth of A. palmata at Barbados was significantly greater than 5 m during some periods of the last deglaciation, notably between 14.5 and 14 kyr B.P. and possibly between 14 and 11.5 kyr B.P. Problem #3/The slow glacio-isostatic adjustment and the rapid responses due to gravitational changes of ice and water masses complicate the interpretation of individual relative sea level (RSL) records at specific locations. Therefore, the Barbados and Tahiti record cannot be compared directly in terms of absolute sea level values as done by Abdul et al. In addition, different glaciohydroisostatic adjustments at the two sites may also have contributed to the observed discrepancy between their deglacial RSL records.

  4. Evidence for phase-locked changes in climate between Scotland and Greenland during GS-1 (Younger Dryas) using micromorphology of glaciolacustrine varves from Glen Roy

    DEFF Research Database (Denmark)

    Palmer, Adrian P.; Rose, Jim; Rasmussen, Sune Olander

    2012-01-01

    There is a current need to develop annual/decadal chronologies from periods of rapid climate change in order to understand the rate and timing of climate events and identify how other proxies either lead or lag this climate forcing. Annually-laminated or varved sediments are key proxies for under...

  5. Youger Dryas and Heinrich events recorded by magnetic susceptibility of sediments from the central temperature area of Western Pacific Warm Pool

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Three short geomagnetic excursions, the Go thenburg, Mono Lake and Mungo (or Maelifell) in the Brunhes Positive Polarity period, were revealed based on the studies of magnetostratigraphy, susceptibility (x) and δ18O of sediments in core WP 92-5 from the central temperature area of the Western Pacific Warm Pool (WPWP), and the ages of them are 12.1-11.3 kaBP, 25.0-24.0 kaBP, and 31.0-28.0 kaBP respectively. Furthermore, the Younger Dryas (YD) and Heinrich (H) cold events were also discov-ered in this core by the susceptibility record. The YD cold event occurred at the depth of 30-22 cm with an age of 11.5-10.6 kaBP; H1, H2 and H3 cold events occurred at depths of 51-39 cm, 108-91 cm and 140-126 cm with ages of 15.1-13.0 kaBP, 25.0-22.1 kaBP and 30.6-28.2 kaBP respectively, which well correspond to the H1, H2, H3 events recorded by susceptibility of core SU90-09 from middle At-lantic, indicating that the susceptibility change of marine sediments can be an important sign of climatic frequent fluc- tuations.

  6. Utilization and Outcomes of Breast Brachytherapy in Younger Women

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Grace L. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Huo, Jinhai [Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Giordano, Sharon H. [Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Hunt, Kelly K. [Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Buchholz, Thomas A. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Smith, Benjamin D., E-mail: bsmith3@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2015-09-01

    .4%; HR 1.71, 95% CI 1.16-2.51). Conclusion: In this younger cohort, endocrine status was a valuable discriminatory factor predicting subsequent mastectomy risk after brachytherapy versus WBI and therefore may be useful for selecting appropriate younger brachytherapy candidates.

  7. Identifying the Relationship of Teacher Candidates' Humor Styles with Anxiety and Self-Compassion Levels

    Science.gov (United States)

    Aydin, Aydan

    2015-01-01

    Problem Statement: Teacher candidates who will soon be responsible for educating the future generations should possess certain characteristics. Specific teacher candidates should have specific characteristics taken into consideration: pre-school and primary teacher candidates should be seen as role models by younger students; psychological…

  8. GASTROINTESTINAL MALIGNANCIES: GETTING A DECADE YOUNGER?

    Directory of Open Access Journals (Sweden)

    Sushmitha

    2014-06-01

    Full Text Available INTRODUCTION: Gastrointestinal malignancies are one of the most common malignancies encountered frequently, with rising incidence in young age due to the changing lifestyle and food habits in India. Oesophagus, stomach and colonic cancers are the commonly affected regions of the GI tract. These malignancies is known to occur in older age of fifth decade onwards. This is a study intended to highlight the rising incidence of such malignancies in the younger age in second to third decade as observed in and around Mangalore. Upper gastrointestinal malignancies are common in oesophagus and stomach, whereas lower gastrointestinal malignancies occur more commonly seen in colon. Colorectal cancer (CRC is one of the most common of all familial malignancies with peak incidence in 60 to 70 years of age, 90% of cases occur in people aged 50 or older.Risk factors include a genetic predisposition, diet and lifestyle changes in the current era. Inheritance plays a role in the pathogenesis of upto a third of CRC cases. AIMS AND OBJECTIVE: To study the prevalence of gastrointestinal malignancies in patients less than fifty years and the association of positive family history and polyps with colorectal carcinomas. MATERIAL AND METHODS: This is a retrospective study of 128 cases of gastrointestinal malignancies from June 2010 to May 2012 received in and around Mangalore. The study includes endoscopic biopsies, colonoscopic biopsies partial and total colectomy specimens with growth seen anywhere from oesophagus to rectum. Representative sections are taken, processed routinely and stained with H & E. The pathological findings are then correlated with clinical data like age and sex distribution, site, family history and presence of other malignancies. RESULTS: In this study gastrointestinal malignancies were studied as upper and lower gastrointestinal lesions. Upper gastrointestinal (GI lesions were those in oesophagus, stomach, and duodenum. A total of 128 cases

  9. [Choice of hip prosthesis in patients younger than 50 years

    NARCIS (Netherlands)

    Schreurs, B.W.; Busch, V.J.; Veth, R.P.H.

    2007-01-01

    There is no agreement about the most ideal type of hip prosthesis to be used in patients younger than 50 years. The most commonly used hip prostheses in patients younger than 50 years are uncemented or resurfacing prostheses and to a lesser extent cemented prostheses. A good result of a hip prosthes

  10. Metacomprehension and Comprehension Performance in Younger and Older Adults.

    Science.gov (United States)

    Moore, DeWayne; And Others

    1997-01-01

    The Metacomprehension Scale was completed by 30 younger and 30 older adults. Younger adults reported greater use of strategies to resolve comprehension failures and valued good comprehension more. The regulation dimension of metacomprehension was a reliable predictor of comprehension performance. (SK)

  11. Cognitive Control and Lexical Access in Younger and Older Bilinguals

    Science.gov (United States)

    Bialystok, Ellen; Craik, Fergus; Luk, Gigi

    2008-01-01

    Ninety-six participants, who were younger (20 years) or older (68 years) adults and either monolingual or bilingual, completed tasks assessing working memory, lexical retrieval, and executive control. Younger participants performed most of the tasks better than older participants, confirming the effect of aging on these processes. The effect of…

  12. Treatment of younger patients with chronic lymphocytic leukemia.

    Science.gov (United States)

    Ferrajoli, Alessandra

    2010-01-01

    Younger patients (defined as patients younger than 50-55 years of age) represent a small group of newly diagnosed patients with chronic lymphocytic leukemia, accounting only for 10% to 20% of newly diagnosed cases. However, once these patients become symptomatic and require treatment, their life expectancy is significantly reduced. Therapeutic approaches for younger patients should be directed at improving survival by achieving a complete remission and, where possible, eradicating minimal residual disease. Chemoimmunotherapy combinations carry the highest response rates and are commonly offered to younger patients. Additional strategies that should be considered for younger patients include early referral for stem-cell transplantation and clinical trials of consolidation therapy to eliminate minimal residual disease.

  13. Stress May Take Greatest Toll on Younger Women's Hearts

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_160597.html Stress May Take Greatest Toll on Younger Women's Hearts: ... 24, 2016 WEDNESDAY, Aug. 24, 2016 (HealthDay News) -- Stress may be especially hard on the hearts of ...

  14. Obesity and sexual dysfunction in younger Danish men

    DEFF Research Database (Denmark)

    Andersen, Ingelise; Heitman, B. L.; Wagner, Gorm

    2008-01-01

    INTRODUCTION: Proportion of populations that are overweight and obese are on the rise and generally affecting more than 50% of the adult Western male population. It is, therefore, of interest to look at possible associations between obesity and sexual function in a homogeneous population. AIM......: To examine a possible association between sexual disorders (erectile dysfunction, ejaculatory disorders, and sexual desire disorders) and obesity among younger men born and living in Denmark. METHODS: A community-based cross-sectional study of sexual health among Danish younger men. Questionnaires were...... the younger obese nonsmokers than obese smokers. Premature ejaculation, retarded ejaculation, and sexual desire disorders were all unrelated to overweight or obesity. CONCLUSION: Obesity (BMI > or = 30 kg/m(2)) seems associated with ED among younger men aged 20-45 years. Health programs directed toward...

  15. CDC Vital Signs: Preventing Pregnancies in Younger Teens

    Science.gov (United States)

    ... AIDS Motor Vehicle Safety Obesity Prescription Drug Overdoses Teen Pregnancy Tobacco Other Digital Media Tools About Vital Signs ... Report (MMWR) CDC Feature - Breaking the Cycle of Teen Pregnancy Vital Signs – Preventing Pregnancy in Younger Teens [ ...

  16. Is Chemo Overused in Younger Colon Cancer Patients?

    Science.gov (United States)

    ... fullstory_163245.html Is Chemo Overused in Younger Colon Cancer Patients? Study found the treatment often wasn't ... 25, 2017 (HealthDay News) -- Young and middle-aged colon cancer patients may be getting chemotherapy more often than ...

  17. Subchondral insufficiency fracture of the femoral head in younger adults

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Takuaki; Nakashima, Yasuharu; Shuto, Toshihide; Jingushi, Seiya; Iwamoto, Yukihide [Graduate School of Medical Sciences, Kyushu University, Department of Orthopaedic Surgery, Fukuoka (Japan)

    2007-06-15

    We report two cases of subchondral insufficiency fracture of the femoral head observed in younger adults without any history of overexertion. In both cases, MRI revealed an irregular, discontinuous low-intensity band on the T1-weighted images. Both patients were treated operatively, and histological examination confirmed the diagnosis of subchondral fracture. A diagnosis of subchondral insufficiency fracture needs to be put in as one of the diagnoses in younger patients with a hip pain. (orig.)

  18. Clinical presentation of urolithiasis in older and younger population

    Directory of Open Access Journals (Sweden)

    Murat Dursun

    2014-12-01

    Full Text Available Aim of the study: We compared stone size, localization, complaint at the time of applying, comorbidity, treatment and complications between older (60 years of age and older and younger patients with urolithiasis (59 years of age and younger. Materials and Methods: We retrospectively reviewed the records of 950 consecutive patients who presented to our clinic and underwent surgery for urolithiasis from January 2007 to March 2012. The patients were divided into two groups: patients ≥ 60 years an patients < 60 years. Results: There were 174 men and 61 women in elderly group, 528 men and 187 women in younger group. Ureteral stones were found more often in the younger group compared to elderly patients (p < 0.05. Conversely, bladder stone was more frequent in the elderly group. In the elderly group comorbidities are more frequent (diabetes mellitus, hypertension, ischemic heart disease, congestive heart disease, osteoarthritis and chronic obstructive lung. Patients ≥ 60 years significantly had larger kidney and bladder stones compared the younger, but ureteral stone sizes were not statistically different between the two groups. Older patients had a higher postoperative complication rate than younger patients (16% versus 3%, p < 0.05 although postoperative complications (e.g. urinary retention, cardiac dysrythmia, fever, constipation were not serious and resolved with medical treatment. The average length of stay in hospital was longer in the elderly group, but the difference was not statistically significant. Conclusions: Elderly patients with urolithiasis usually have larger and more complex stone disease, more comorbidities and atypical presentation.

  19. Backward compatibility effects in younger and older adults.

    Science.gov (United States)

    Hartley, Alan A; Maquestiaux, François; Festini, Sara B; Frazier, Kathryn; Krimmer, Patricia J

    2016-07-01

    In many dual-task situations, responses to the second of two tasks are slowed when the time between tasks is short. The response-selection bottleneck model of dual-task performance accounts for this phenomenon by assuming that central processing of the second task is blocked by a bottleneck until central processing of Task 1 is complete. This assumption could be called into question if it could be demonstrated that the response to Task 2 affected the central processing of Task 1, a backward response compatibility effect. Such effects are well-established in younger adults. Backward compatibility effects in older (as well as younger) adults were explored in two experiments. The first experiment found clear backward response compatibility effects for younger adults but no evidence of them for older adults. The second experiment explored backward stimulus compatibility and found similar effects in both younger and older adults. Evidence possibly consistent with some pre-bottleneck processing of Task 2 central stages also was found in the second experiment in both age groups. For younger adults, the results provide further evidence falsifying the claim of an immutable response selection bottleneck. For older adults, the evidence suggested that Task 2 affects Task 1 when there is stimulus compatibility but not when there is response compatibility.

  20. Independent candidates in Mexico

    OpenAIRE

    Campos, Gonzalo Santiago

    2014-01-01

    In this paper we discuss the issue of independent candidates in Mexico, because through the so-called political reform of 2012 was incorporated in the Political Constitution of the Mexican United States the right of citizens to be registered as independent candidates. Also, in September 2013 was carried out a reform of Article 116 of the Political Constitution of the Mexican United States in order to allow independent candidates in each state of the Republic. However, prior to the constitutio...

  1. Differences in reasons for smoking between younger and older smokers.

    Science.gov (United States)

    Oei, T P; Tilley, D; Gow, K

    1991-01-01

    The reasons why older people smoke have not been examined in the literature. This paper attempted to examine the differences in motivation and maintenance factors of elderly and young smokers using the Horn-Waingrow Why do you smoke questionnaire. One hundred and thirteen clinical patients and 112 non-patient controls were used in this study. The clinical group was divided into an elderly group (n = 58) and a younger group (n = 55). The results of a discriminant analysis showed that patients significantly differed from non-patients on 'automatic habit and stimulation', and 'crutch/tension reduction' factors. Elderly patients were found to be significantly differentiated from both younger patients and the control group on the 'pleasurable relaxation' factor. These findings offer support for the US Surgeon Generals' report that elderly smokers do have different motivating factors for their smoking behaviours from younger smokers.

  2. Body Image in Younger Breast Cancer Survivors: A Systematic Review

    Science.gov (United States)

    Paterson, Carly; Lengacher, Cecile A.; Donovan, Kristine A.; Kip, Kevin E.; Tofthagen, Cindy S.

    2015-01-01

    Background Body image is a complex issue with the potential to impact many aspects of cancer survivorship, particularly for the younger breast cancer survivor. Objective The purpose of this review is to synthesize the current state of the science for body image in younger women with breast cancer. Intervention/Methods Combinations of the terms “body image,” “sexuality intervention,” “women,” “younger women,” and “breast cancer” were searched in the PubMed, PsycInfo, CINAHL, Web of Knowledge and Science Direct databases through January 2014. Inclusion criteria for this review were: 1) original research; 2) published in English from the year 2000 forward; 3) measuring body image as an outcome variable; and 4) results included reporting of age-related outcomes. Results Thirty-six articles met the inclusion criteria. The majority of studies were cross-sectional, with extensive variation in body image assessment tools. Age and treatment type had a significant impact on body image, and poorer body image was related to physical and psychological distress, sex and intimacy, and the partnered relationship among younger women. Only one intervention study found a significant improvement in body image post-intervention. Conclusions Findings suggest body image is a complex post-treatment concern for breast cancer survivors, particularly younger women. The findings of this review are limited by the high level of variation in the methods for assessing body image. Implications for Practice Further research of interventions to address body image concerns following treatment for breast cancer is warranted. Improvement of body image may improve the quality of life of younger breast cancer survivors. PMID:25881807

  3. Media use by children younger than 2 years.

    Science.gov (United States)

    Brown, Ari

    2011-11-01

    In 1999, the American Academy of Pediatrics (AAP) issued a policy statement addressing media use in children. The purpose of that statement was to educate parents about the effects that media--both the amount and the content--may have on children. In one part of that statement, the AAP recommended that "pediatricians should urge parents to avoid television viewing for children under the age of two years." The wording of the policy specifically discouraged media use in this age group, although it is frequently misquoted by media outlets as no media exposure in this age group. The AAP believed that there were significantly more potential negative effects of media than positive ones for this age group and, thus, advised families to thoughtfully consider media use for infants. This policy statement reaffirms the 1999 statement with respect to media use in infants and children younger than 2 years and provides updated research findings to support it. This statement addresses (1) the lack of evidence supporting educational or developmental benefits for media use by children younger than 2 years, (2) the potential adverse health and developmental effects of media use by children younger than 2 years, and (3) adverse effects of parental media use (background media) on children younger than 2 years.

  4. Older and Younger Workers: The Equalling Effects of Health

    Science.gov (United States)

    Beck, Vanessa; Quinn, Martin

    2012-01-01

    Purpose: The purpose of this paper is to consider the statistical evidence on the effects that ill health has on labour market participation and opportunities for younger and older workers in the East Midlands (UK). Design/methodology/approach: A statistical analysis of Labour Force Survey data was undertaken to demonstrate that health issues…

  5. Memory Dynamics and Decision Making in Younger and Older Adults

    Science.gov (United States)

    Lechuga, M. Teresa; Gomez-Ariza, Carlos J.; Iglesias-Parro, Sergio; Pelegrina, Santiago

    2012-01-01

    The main aim of this research was to study whether memory dynamics influence older people's choices to the same extent as younger's ones. To do so, we adapted the retrieval-practice paradigm to produce variations in memory accessibility of information on which decisions were made later. Based on previous results, we expected to observe…

  6. On Younger Stakeholders and Decommissioning of Nuclear Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Tyszkiewicz, Bogumila; Labor, Bea

    2009-08-15

    In modern democratic countries, information sharing and effective and open communication concerning dismantling and decommissioning of of nuclear facilities as well as the management of nuclear waste are essential for the task to build the confidence required for any further development of nuclear energy. At the same time, it is often perceived that all decision making processes about nuclear energy policies are probably increasingly influenced by public opinion. Nuclear and radiation safety Authorities have a clear role in this regard to provide unbiased information on any health and safety related issues. In order to meet this need, it is necessary for Authorities and others to understand the values and opinions of the citizens, and especially the younger ones. They hold the key to the future at the same time as their perspective on these issues is the least understood. The need of greater public participation in decision making is becoming increasingly recognised the scientific as well as the political community. Many activities are carried out in order to stimulate to higher levels of public involvement in decision making in this active research area. Younger citizens is a stakeholder group that is often excluded in decision- making processes. The existence of large gaps between the involvement of older and younger stakeholders in decision making processes needs to be addressed, since such imbalances might otherwise lead to unequal opportunities between generations and limit the future consumption level of the coming generations. Another demanding task for the present generation is to assure that appropriate financial resources are injected into the Swedish Nuclear Waste Fund. It will thereby be possible for coming generations to undertake efficient measures in the decommissioning and dismantling of older nuclear facilities. To undertake such measures in line with the environmental and health codex is essential. An appropriate balance in this regard must be

  7. Clinical Analysis of Lung Cancer Patients Younger Than 30 Years

    Directory of Open Access Journals (Sweden)

    Guangjie HOU

    2011-05-01

    Full Text Available Background and objective It is common recognized that young patients of lung cancer have poor prognosis due to relatively higher malignancy and more invasive growth. In the past most studies on young patients of lung cancer selected patients younger than 40 or 45 years old, and there were few clinical materials for younger patients under 30 years. This study retrospectively described the the disease history, stage, treatment and pathology features of lung cancer patients younger than 30 years and aimed to provide references for these patients. Methods Those patients younger than 30 years, once admitted in the General Hospital of the People's Liberation Army for lung cancer from 1993 to date, were sought in medical record system, and 53 patients were found in total. In this group, there were 34 non-small cell lung cancer (NSCLC patients and 19 small cell lung cacer (SCLC patients. The male/female ratio was 1.5:1. In the NSCLC patients, there were 27 adenocarcinomas, 6 squamous carcinomas and 1 adenosquamous carcinoma, with no large cell carcinoma involved. In these patients, 12 patients received operations while 38 patients got chemo- and/or radiotherapy and 3 quited any treatment. Results There was no death in hospital, however, in the 12 patients who got operation, only 8 patients got complete resection while 4 patients got palliative resection. Conclusion Lung cancer patients younger than 30 years had a high fraction of adenocarcinoma and small cell type pathologically and most of them were in late stage when presenting with symptoms in hospital and would have a dismal prognosis. The routine health examination and early diagnosis should be emphasized to improve the prognosis of these patients.

  8. Inferring the Provenance of an Alien Species with DNA Barcodes: The Neotropical Butterfly Dryas iulia in Thailand

    Science.gov (United States)

    Burg, Noah A.; Pradhan, Ashman; Gonzalez, Rebecca M.; Morban, Emely Z.; Zhen, Erica W.; Sakchoowong, Watana; Lohman, David J.

    2014-01-01

    The Neotropical butterfly Dryas iulia has been collected from several locations in Thailand and Malaysia since 2007, and has been observed breeding in the wild, using introduced Passiflora foetida as a larval host plant. The butterfly is bred by a butterfly house in Phuket, Thailand, for release at weddings and Buddhist ceremonies, and we hypothesized that this butterfly house was the source of wild, Thai individuals. We compared wing patterns and COI barcodes from two, wild Thai populations with individuals obtained from this butterfly house. All Thai individuals resemble the subspecies D. iulia modesta, and barcodes from wild and captive Thai specimens were identical. This unique, Thai barcode was not found in any of the 30 specimens sampled from the wild in the species' native range, but is most similar to specimens from Costa Rica, where many exporting butterfly farms are located. These data implicate the butterfly house as the source of Thailand's wild D. iulia populations, which are currently so widespread that eradication efforts are unlikely to be successful. PMID:25119899

  9. Older (but not younger) siblings facilitate false belief understanding.

    Science.gov (United States)

    Ruffman, T; Perner, J; Naito, M; Parkin, L; Clements, W A

    1998-01-01

    Results from 4 experiments and an analysis in which all data from 444 English and Japanese children are pooled show (a) a linear increase in understanding false belief with the number of older siblings, (b) no such effect for children younger than 3 years 2 months, (c) no helpful effect of younger siblings at any age (despite the large sample), (d) no effect of siblings' gender, and (e) no helpful effect of siblings on a task measuring children's understanding of how they know something. Discussion involves speculation about how older siblings may assist children (e.g., through pretend play and mental state language) and how different aspects of a theory of mind may develop through different means.

  10. Hip and Knee Osteoarthritis Affects Younger People, Too.

    Science.gov (United States)

    Ackerman, Ilana N; Kemp, Joanne L; Crossley, Kay M; Culvenor, Adam G; Hinman, Rana S

    2017-02-01

    Synopsis Although osteoarthritis (OA) has traditionally been considered a disease of older age, hip and knee OA can and does affect younger adults, with a profound impact on psychosocial well-being and work capacity. Obesity and a history of traumatic knee injury (eg, anterior cruciate ligament rupture and/or meniscal tear) are key risk factors for the accelerated development of knee OA, while structural hip deformities (including those contributing to femoroacetabular impingement syndrome) are strong predictors of early-onset hip OA. In view of these associations, rising rates of obesity and sports injuries are concerning, and may signal a future surge in OA incidence among younger people. Assessment of hip and knee OA in younger people should focus on a patient-centered history, comprehensive physical examination, performance-based measures, and patient-reported outcome measures to enable monitoring of symptoms and function over time. Referral for imaging should be reserved for people presenting with atypical signs or symptoms that may indicate diagnoses other than OA. Nonpharmacological approaches are core strategies for the management of hip and knee OA in younger people, and these include appropriate disease-related education, activity modification (including for work-related tasks), physical therapist- prescribed exercise programs to address identified physical impairments, and weight control or weight loss. High-quality evidence has shown no benefit of arthroscopy for knee OA, and there are no published clinical trials to support the use of hip arthroscopy for OA. Referral for joint-conserving or joint replacement surgery should be considered when nonpharmacological and pharmacological management strategies are no longer effective. J Orthop Sports Phys Ther 2017;47(2):67-79. doi:10.2519/jospt.2017.7286.

  11. Attachment and Aggressive Manifestations in Younger Adulthood - "Preliminary Findings"

    OpenAIRE

    Tatiana Lorincová

    2014-01-01

    The main topic of the contribution was comparison between retrospective attachment (emocional warmth and rejection) and aggressive manifestations (physical aggressivness, verbal aggressivness, anger and hostility) among younger adulthood. Bowlby's theory of attachment was that once a core attachment style develops in an infant, it will influence and shape the nature of all intimate relations for the individual moving forward throughout the infant's life cycle. Authors Mikulincer and Shaver...

  12. Are Younger or Older Cohorts Hurt the Most?

    OpenAIRE

    Raymundo M. Campos-Vazquez; Luis F. Lopez-Calva; Lustig, Nora

    2016-01-01

    Wage inequality has declined in Mexico since 2000. Using data from Mexican labor surveys for the period between 2000 and 2014, this paper investigates whether the decline was driven by wages declining more sharply for younger or older workers. The analysis finds that the wages of older workers declined and the decline was more pronounced in the older cohort. This would seem to support the ...

  13. Root tensile strength assessment of Dryas octopetala L. and implications for its engineering mechanism on lateral moraine slopes (Turtmann Valley, Switzerland)

    Science.gov (United States)

    Eibisch, Katharina; Eichel, Jana; Dikau, Richard

    2015-04-01

    Geomorphic processes and properties are influenced by vegetation. It has been shown that vegetation cover intercepts precipitation, enhances surface detention and storage, traps sediment and provides additional surface roughness. Plant roots impact the soil in a mechanical and hydrological manner and affect shear strength, infiltration capacity and moisture content. Simultaneously, geomorphic processes disturb the vegetation development. This strong coupling of the geomorphic and ecologic system is investigated in Biogeomorphology. Lateral moraine slopes are characterized by a variety of geomorphic processes, e. g. sheet wash, solifluction and linear erosion. However, some plant species, termed engineer species, possess specific functional traits which allow them to grow under these conditions and also enable them to influence the frequency, magnitude and even nature of geomorphic processes. For lateral moraine slopes, Dryas octopetala L., an alpine dwarf shrub, was identified as a potential engineer species. The engineering mechanism of D. octopetala, based on its morphological (e.g., growth form) and biomechanical (e.g., root strength) traits, yet remains unclear and only little research has been conducted on alpine plant species. The objectives of this study are to fill this gap by (A) quantifying D. octopetala root tensile strength as an important trait considering anchorage in and stabilization of the slope and (B) linking plant traits to the geomorphic process they influence on lateral moraine slopes. D. octopetala traits were studied on a lateral moraine slope in Turtmann glacier forefield, Switzerland. (A) Root strength of single root threads of Dryas octopetala L. were tested using the spring scale method (Schmidt et al., 2001; Hales et al., 2013). Measurement equipment was modified to enable field measurements of roots shortly after excavation. Tensile strength of individual root threads was calculated and statistically analyzed. First results show that

  14. Stress modulates reinforcement learning in younger and older adults.

    Science.gov (United States)

    Lighthall, Nichole R; Gorlick, Marissa A; Schoeke, Andrej; Frank, Michael J; Mather, Mara

    2013-03-01

    Animal research and human neuroimaging studies indicate that stress increases dopamine levels in brain regions involved in reward processing, and stress also appears to increase the attractiveness of addictive drugs. The current study tested the hypothesis that stress increases reward salience, leading to more effective learning about positive than negative outcomes in a probabilistic selection task. Changes to dopamine pathways with age raise the question of whether stress effects on incentive-based learning differ by age. Thus, the present study also examined whether effects of stress on reinforcement learning differed for younger (age 18-34) and older participants (age 65-85). Cold pressor stress was administered to half of the participants in each age group, and salivary cortisol levels were used to confirm biophysiological response to cold stress. After the manipulation, participants completed a probabilistic learning task involving positive and negative feedback. In both younger and older adults, stress enhanced learning about cues that predicted positive outcomes. In addition, during the initial learning phase, stress diminished sensitivity to recent feedback across age groups. These results indicate that stress affects reinforcement learning in both younger and older adults and suggests that stress exerts different effects on specific components of reinforcement learning depending on their neural underpinnings.

  15. On Younger Stakeholders and Decommissioning of Nuclear Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Tyszkiewicz, Bogumila; Labor, Bea

    2009-08-15

    In modern democratic countries, information sharing and effective and open communication concerning dismantling and decommissioning of of nuclear facilities as well as the management of nuclear waste are essential for the task to build the confidence required for any further development of nuclear energy. At the same time, it is often perceived that all decision making processes about nuclear energy policies are probably increasingly influenced by public opinion. Nuclear and radiation safety Authorities have a clear role in this regard to provide unbiased information on any health and safety related issues. In order to meet this need, it is necessary for Authorities and others to understand the values and opinions of the citizens, and especially the younger ones. They hold the key to the future at the same time as their perspective on these issues is the least understood. The need of greater public participation in decision making is becoming increasingly recognised the scientific as well as the political community. Many activities are carried out in order to stimulate to higher levels of public involvement in decision making in this active research area. Younger citizens is a stakeholder group that is often excluded in decision- making processes. The existence of large gaps between the involvement of older and younger stakeholders in decision making processes needs to be addressed, since such imbalances might otherwise lead to unequal opportunities between generations and limit the future consumption level of the coming generations. Another demanding task for the present generation is to assure that appropriate financial resources are injected into the Swedish Nuclear Waste Fund. It will thereby be possible for coming generations to undertake efficient measures in the decommissioning and dismantling of older nuclear facilities. To undertake such measures in line with the environmental and health codex is essential. An appropriate balance in this regard must be

  16. The influence of political candidates’ facial appearance on older and younger adults’ voting choices and actual electoral success

    Directory of Open Access Journals (Sweden)

    Robert G. Franklin

    2016-12-01

    Full Text Available Younger adults (YA judgments of political candidates’ competence from facial appearance accurately predict electoral success. Whether this is true for older adults (OA has not been investigated despite the fact that OA are more likely to vote than YA and may respond differently to particular facial qualities. We examined whether OA and YA ratings of competence, trustworthiness, attractiveness, and babyfaceness of opposing candidates in US Senate elections independently predicted their own vote choices and actual election outcomes. OA and YA ratings of attractiveness, competence, and trustworthiness positively predicted their choices, but the effect of competence was weaker for OA. Babyfaceness negatively predicted OA, but not YA, choices. OA and YA competence ratings equally predicted the actual election winners, while OA, but not YA, attractiveness ratings did so. Trustworthy and babyface ratings did not predict actual winners. These findings have implications for understanding age differences in candidate preferences and the prediction of election outcomes.

  17. Primary and Presidential Candidates

    DEFF Research Database (Denmark)

    Goddard, Joseph

    2012-01-01

    This article looks at primary and presidential candidates in 2008 and 2012. Evidence suggests that voters are less influenced by candidates’ color, gender, or religious observation than previously. Conversely, markers of difference remain salient in the imaginations of pollsters and journalists...

  18. MBM12 A Younger Version of the TW Hydrae Association?

    CERN Document Server

    Wolk, S J; Jayawardhana, R; Hearty, T J; Wolk, Scott J.; Cover, Rebecca T.; Jayawardhana, Ray; Hearty, Thomas J.

    2000-01-01

    We present optical and infrared photometry of stars near the MBM 12 dark cloud. The optical data indicate that there are about 40 candidate pre-main sequence stars in the same area currently occupied by eight bona-fide PMS stars. Analysis of 2MASS data suggests that 60% of PMS candidates have been detected. Some of these show evidence of optically thick disks. Our study of the 2MASS data also reveals a large enhancement of sources within the MBM 12 cloud, indicating that it is still actively forming stars.

  19. Leg Strength Comparison between Younger and Middle-age Adults.

    Science.gov (United States)

    Kim, Sukwon; Lockhart, Thurmon; Nam, Chang S

    2010-05-01

    Although a risk of occupational musculoskeletal diseases has been identified with age-related strength degradation, strength measures from working group are somewhat sparse. This is especially true for the lower extremity strength measures in dynamic conditions (i.e., isokinetic). The objective of this study was to quantify the lower extremity muscle strength characteristics of three age groups (young, middle, and the elderly). Total of 42 subjects participated in the study: 14 subjects for each age group. A commercial dynamometer was used to evaluate isokinetic and isometric strength at ankle and knee joints. 2 × 2 (Age group (younger, middle-age, and older adult groups) × Gender (male and female)) between-subject design and Post-hoc analysis were performed to evaluate strength differences among three age groups. Post-hoc analysis indicated that, overall, middle-age workers' leg strengths (i.e. ankle and knee muscles) were significantly different from younger adults while middle-age workers' leg strengths were virtually identical to older adults' leg strengths. These results suggested that, overall, 14 middle-age workers in the present study could be at a higher risk of musculoskeletal injuries. Future studies looking at the likelihood of musculoskeletal injuries at different work places and from different working postures at various age levels should be required to validate the current findings. The future study would be a valuable asset in finding intervention strategies such that middle-age workers could stay healthier longer.

  20. Attachment and Aggressive Manifestations in Younger Adulthood - "Preliminary Findings"

    Directory of Open Access Journals (Sweden)

    Tatiana Lorincová

    2014-07-01

    Full Text Available The main topic of the contribution was comparison between retrospective attachment (emocional warmth and rejection and aggressive manifestations (physical aggressivness, verbal aggressivness, anger and hostility among younger adulthood. Bowlby's theory of attachment was that once a core attachment style develops in an infant, it will influence and shape the nature of all intimate relations for the individual moving forward throughout the infant's life cycle. Authors Mikulincer and Shaver (2011 explain how these primary attachment experiences would affect future emotional, cognitive and behavioral processes. Secure adolescents, in comparison to insecure ones are perceived as being less aggressive. Research has pointed out that secure parental attachment promotes adaptive psychological functioning. The direct relationship between attachment security and aggressive/delinquent behaviour is in line with prior evidence that secure adolescents rate higher in terms of emotional and social adjustment, enjoy more positive relationships with their family and peers, and are less likely to engage in externalizing problems, such as antisocial and aggressive behaviours. On the other hand, insecure attachment is connected with aggressive and externalizing behaviour. Hypotheses were formulated on the base of theoretical background and our assumption was, that younger adults with emocional warmth attachment will have lower level of aggressive manifestations (physical aggression, verbal aggression, anger and hostility than younger adults with rejectional attachment. We used two standardized questionnaires for data collection, s.E.M.B.U. Questionnaire, which measured retrospective attachment (emocional warmth and rejection and Questionnaire of Aggressivness, which measured aggressive manifestations. We used statistical analysis and we found statistically significant differencies, which are preliminary findings from broader research, between emocional warmth

  1. Pilot Candidate Selection

    Science.gov (United States)

    1989-05-01

    pilot selection system and to best support up-front track selection for SUPT? Assumptions The USAF Trainer Masterplan does not include a plan to...replace the T-41 with a new flight screening aircraft. In addition, the Masterplan states that candidates will be track selected prior to entry into primary...training. (3:10) While the Masterplan is not a static document and aircraft procurement plans and/or the timing of track selection are subject to

  2. Kids 14 and Younger Only Need 2 HPV Vaccine Shots: CDC

    Science.gov (United States)

    ... html Kids 14 and Younger Only Need 2 HPV Vaccine Shots: CDC But agency's revised guidelines still recommend ... and younger require only two doses of the HPV vaccine rather than the previously recommended three shots, U.S. ...

  3. How do older netcitizens compare with their younger counterparts?

    Science.gov (United States)

    Bucur, A; Renold, C; Henke, M

    1999-01-01

    The Internet is modifying the lives of people around the world. Although many talk about the democratization of knowledge and information, differences remain among users as older netcitizens are under-represented and less involved. We use national and representative U.S. data, the Current Population Survey, to show age-based differences. We complement our analysis with web-based data, the Georgia Tech World Wide Web User Surveys, to show Internet characteristics and trends by age for netcitizens. Results show that older users compose a lower share of Internet users than that of the total U.S. population; however, once they join the ranks of avid Internet users, older netcitizens are similar to their younger counterparts.

  4. Habitual fat intake predicts memory function in younger women

    Directory of Open Access Journals (Sweden)

    Edward Leigh eGibson

    2013-12-01

    Full Text Available High intakes of fat have been linked to greater cognitive decline in old age, but such associations may already occur in younger adults. We tested memory and learning in 38 women (25-45 years old, recruited for a larger observational study in women with polycystic ovary syndrome. These women varied in health status, though not significantly between cases (n=23 and controls (n=15. Performance on tests sensitive to medial temporal lobe function (CANTABeclipse, Cambridge Cognition Ltd., i.e. verbal memory, visuo-spatial learning and delayed pattern matching, were compared with intakes of macronutrients from 7-day diet diaries and physiological indices of metabolic syndrome. Partial correlations were adjusted for age, activity and verbal IQ (National Adult Reading Test. Greater intakes of saturated and trans fats, and higher saturated to unsaturated fat ratio (Sat:UFA, were associated with more errors on the visuo-spatial task and with poorer word recall and recognition. Unexpectedly, higher UFA intake predicted poorer performance on the word recall and recognition measures. Fasting insulin was positively correlated with poorer word recognition only, whereas higher blood total cholesterol was associated only with visuo-spatial learning errors. None of these variables predicted performance on a delayed pattern matching test. The significant nutrient-cognition relationships were tested for mediation by total energy intake: saturated and trans fat intakes, and Sat:UFA, remained significant predictors specifically of visuo-spatial learning errors, whereas total fat and UFA intakes now predicted only poorer word recall. Examination of associations separately for mono- (MUFA and polyunsaturated fats suggested that only MUFA intake was predictive of poorer word recall. Saturated and trans fats, and fasting insulin, may already be associated with cognitive deficits in younger women. The findings need extending but may have important implications for public

  5. Otitis media with effusion in children younger than 1 year

    Science.gov (United States)

    Di Francesco, Renata Cantisani; Barros, Vivian Boschesi; Ramos, Rafael

    2016-01-01

    Abstract Objective: To determine the prevalence of otitis media with effusion in children younger than 1 year and its association with the season of the year, artificial feeding, environmental and perinatal factors. Methods: Retrospective study of 184 randomly included medical records from a total of 982 healthy infants evaluated for hearing screening tests. Diagnosis of otitis media with effusion was based on otoscopy (amber-gold color, fluid level, handle of malleus position), type B tympanometric curves and absence of otoacoustic emissions. Incomplete medical records or those describing acute otitis media, upper respiratory tract infections on the assessment day or in the last 3 months, neuropathies and craniofacial anomalies were excluded. Data such as gestational age, birth weight, Apgar score, type of feeding and day care attendance were compared between children with and without otitis media with effusion through likelihood tests and multivariate analysis. Results: 25.3% of 184 infants had otitis media with bilateral effusion; 9.2% had unilateral. In infants with otitis media, the following were observed: chronological age of 9.6±1.7 months; gestational age >38 weeks in 43.4% and birth weight >2500g in 48.4%. Otitis media with effusion was associated with winter/fall, artificial feeding, Apgar score <7 and day care attendance. The multivariate analysis showed that artificial feeding is the factor most often associated to otitis media with effusion. Conclusions: Otitis media with effusion was found in about one third of children younger than 1 year and was mainly associated with artificial feeding. PMID:26559603

  6. Otitis media with effusion in children younger than 1 year

    Directory of Open Access Journals (Sweden)

    Renata Cantisani Di Francesco

    2016-06-01

    Full Text Available Abstract Objective: To determine the prevalence of otitis media with effusion in children younger than 1 year and its association with the season of the year, artificial feeding, environmental and perinatal factors. Methods: Retrospective study of 184 randomly included medical records from a total of 982 healthy infants evaluated for hearing screening tests. Diagnosis of otitis media with effusion was based on otoscopy (amber-gold color, fluid level, handle of malleus position, type B tympanometric curves and absence of otoacoustic emissions. Incomplete medical records or those describing acute otitis media, upper respiratory tract infections on the assessment day or in the last 3 months, neuropathies and craniofacial anomalies were excluded. Data such as gestational age, birth weight, Apgar score, type of feeding and day care attendance were compared between children with and without otitis media with effusion through likelihood tests and multivariate analysis. Results: 25.3% of 184 infants had otitis media with bilateral effusion; 9.2% had unilateral. In infants with otitis media, the following were observed: chronological age of 9.6±1.7 months; gestational age >38 weeks in 43.4% and birth weight >2500g in 48.4%. Otitis media with effusion was associated with winter/fall, artificial feeding, Apgar score <7 and day care attendance. The multivariate analysis showed that artificial feeding is the factor most often associated to otitis media with effusion. Conclusions: Otitis media with effusion was found in about one third of children younger than 1 year and was mainly associated with artificial feeding.

  7. Immunization Uptake in Younger Siblings of Children with Autism Spectrum Disorder

    Science.gov (United States)

    Kuwaik, Ghassan Abu; Roberts, Wendy; Zwaigenbaum, Lonnie; Bryson, Susan; Smith, Isabel M.; Szatmari, Peter; Modi, Bonnie M.; Tanel, Nadia; Brian, Jessica

    2014-01-01

    Background: Parental concerns persist that immunization increases the risk of autism spectrum disorder, resulting in the potential for reduced uptake by parents of younger siblings of children with autism spectrum disorder ("younger sibs"). Objective: To compare immunization uptake by parents for their younger child relative to their…

  8. Younger and Older Users’ Recognition of Virtual Agent Facial Expressions

    Science.gov (United States)

    Beer, Jenay M.; Smarr, Cory-Ann; Fisk, Arthur D.; Rogers, Wendy A.

    2015-01-01

    As technology advances, robots and virtual agents will be introduced into the home and healthcare settings to assist individuals, both young and old, with everyday living tasks. Understanding how users recognize an agent’s social cues is therefore imperative, especially in social interactions. Facial expression, in particular, is one of the most common non-verbal cues used to display and communicate emotion in on-screen agents (Cassell, Sullivan, Prevost, & Churchill, 2000). Age is important to consider because age-related differences in emotion recognition of human facial expression have been supported (Ruffman et al., 2008), with older adults showing a deficit for recognition of negative facial expressions. Previous work has shown that younger adults can effectively recognize facial emotions displayed by agents (Bartneck & Reichenbach, 2005; Courgeon et al. 2009; 2011; Breazeal, 2003); however, little research has compared in-depth younger and older adults’ ability to label a virtual agent’s facial emotions, an import consideration because social agents will be required to interact with users of varying ages. If such age-related differences exist for recognition of virtual agent facial expressions, we aim to understand if those age-related differences are influenced by the intensity of the emotion, dynamic formation of emotion (i.e., a neutral expression developing into an expression of emotion through motion), or the type of virtual character differing by human-likeness. Study 1 investigated the relationship between age-related differences, the implication of dynamic formation of emotion, and the role of emotion intensity in emotion recognition of the facial expressions of a virtual agent (iCat). Study 2 examined age-related differences in recognition expressed by three types of virtual characters differing by human-likeness (non-humanoid iCat, synthetic human, and human). Study 2 also investigated the role of configural and featural processing as a

  9. Hiding its age: the case for a younger bulge

    CERN Document Server

    Haywood, M; Snaith, O; Calamida, A

    2016-01-01

    The determination of the age of the bulge has led to two contradictory results. On the one side, the color-magnitude diagrams in different bulge fields seem to indicate a uniformly old ($>$10 Gyr) population. On the other side, individual ages derived from dwarfs observed through microlensing events seem to indicate a large spread, from $\\sim$ 2 to $\\sim$ 13 Gyr. Because the bulge is now recognised as being mainly a boxy peanut-shaped bar, it is suggested that disk stars are one of its main constituents, and therefore also stars with ages significantly younger than 10 Gyr. Other arguments as well point to the fact that the bulge cannot be exclusively old, and in particular cannot be a burst population, as it is usually expected if the bulge was the fossil remnant of a merger phase in the early Galaxy. In the present study, we show that given the range of metallicities observed in the bulge, a uniformly old population would be reflected into a significant spread in color at the turn-off which is not observed. ...

  10. Parkin gene mutations in younger onset Parkinson's disease

    Institute of Scientific and Technical Information of China (English)

    Piu Chan; Hua Bai; Rong Chen; J Willian Langston

    2000-01-01

    Objective': To screen for exonic and point mutations in the Parkin gene in both Chinese and American Caucasian younger onset Parkinson's disease (YOPD) patients.Background: Recently, the Autosomal recessive juvenile parkinsonism (ARJP) gene was first mapped to chromosome 6q25.2-27 and was late cloned and designated as Parkin. A wide variety of mutations, including homozygous exonic deletions and point mutations,have been found in at least more than 50 ARJP families of Japanese, European and Jewish origins. However, the distribution of Parkin gene mutations is not known in the Chinese and American Caucasians, It is also not clear how frequent the Parkin gene mutations occur in YOPD patients. Method and Material: Twenty-one Chinese subjects were selected from 121 Chinese PD inpatients who were admitted to the Xuanwu Hospital in Beijing between August of 1998 and April of 1999 and had an onset before age 51. Thirty-eight American subjects were PD patients with an onset before age 41 from the Tissue Bank of the Parkinson′s Institute at California. Homozygous exonic deletion and point mutations in all 12 exons of the Parkin gene were screened using PCR, SSCP and direct sequencing methods. Mutations identified by sequencing were further confirmed by restriction enzyme digestion. Results: Five different types of homozygous deletion mutations (exons 1, 4, 6, 7 and 12) were found in 7 out of 21 Chinese cases but none of the 37 American Caucasian patients in all 12 exons of Parkin gene. One novel and four polymorphic mutationswere found in the American Caucasian YOPD cases.Conclusion: our results suggest that homozygous exonic deletions in the Parkin gene may account for a significant amount of YOPD in the Chinese but not in the American Caucasian YOPD.

  11. Factors associated with younger adolescents' exposure to online alcohol advertising.

    Science.gov (United States)

    D'Amico, Elizabeth J; Martino, Steven C; Collins, Rebecca L; Shadel, William G; Tolpadi, Anagha; Kovalchik, Stephanie; Becker, Kirsten M

    2017-03-01

    Little is known about the extent and nature of youth exposure to online alcohol advertising, or factors that may be associated with exposure. The current study recruited middle school students who completed a paper survey and then logged each alcohol advertisement that they encountered over a 2-week period using cell phones as part of an ecological momentary assessment design. We examined the percentage of youth who reported exposure to online alcohol advertising in the past 2 weeks, average weekly rate of exposure, types of online alcohol advertisements youth reported seeing, and factors that increased youths' risk of exposure to online alcohol advertising. Analyses are based on 485 participants (47% female; 25% Hispanic, 25% White, 27% Black; 6% Asian, 16% other). Youth logged exposures to a total of 3,966 (16,018 weighted for underreporting) alcohol advertisements across the monitoring period; 154 (568 weighted) or 3.6% were online ads. Seventeen percent of youth reported seeing any online alcohol ad; the majority of online ads seen were video commercials (44.8%) and banner/side ads (26.6%). Factors associated with greater ad exposure were being older, rebellious, and Black race; greater parental monitoring and more hours spent on social media were associated with less exposure. Findings provide important information about adolescents' exposure to online alcohol advertising and what might contribute to a greater likelihood of exposure. Given that online ad exposure is linked to drinking behavior, prevention programming for younger adolescents should continue to address this issue to help youth make healthy choices regarding alcohol use. (PsycINFO Database Record

  12. Younger Children's (Three to Five Years) Perceptions of Being in a Health-Care Situation

    Science.gov (United States)

    Stålberg, Anna; Sandberg, Anette; Söderbäck, Maja

    2016-01-01

    Younger children are common users of health-care services. Their perspective on a health-care situation and their ways of communication differ from that of adults. There is a shortness of research of younger children's perceptions of health-care situations. The knowledge that exists indicates the importance of involving the child's perspective to…

  13. A Group-Based Program of Emotional Recovery for Younger Women Following Myocardial Infarction

    Science.gov (United States)

    Bowers, Michele J.; Buchanan, Marla J.

    2007-01-01

    Heart disease is the leading cause of illness, disability, and death among women in Canada. Myocardial infarction (MI) accounts for almost half of these deaths yearly. The purpose of this study was to understand younger women's experience of recovery from MI. A purposive sample consisting of six younger women diagnosed with MI participated in …

  14. The role of prior knowledge in error correction for younger and older adults.

    Science.gov (United States)

    Sitzman, Danielle M; Rhodes, Matthew G; Tauber, Sarah K; Liceralde, Van Rynald T

    2015-01-01

    Previous work has demonstrated that, when given feedback, younger adults are more likely to correct high-confidence errors compared with low-confidence errors, a finding termed the hypercorrection effect. Research examining the hypercorrection effect in both older and younger adults has demonstrated that the relationship between confidence and error correction was stronger for younger adults compared with older adults. Their results demonstrated that the relationship between confidence and error correction was stronger for younger adults compared with older adults. However, recent work suggests that error correction is largely related to prior knowledge, while confidence may primarily serve as a proxy for prior knowledge. Prior knowledge generally remains stable or increases with age; thus, the current experiment explored how both confidence and prior knowledge contributed to error correction in younger and older adults. Participants answered general knowledge questions, rated how confident they were that their response was correct, received correct answer feedback, and rated their prior knowledge of the correct response. Overall, confidence was related to error correction for younger adults, but this relationship was much smaller for older adults. However, prior knowledge was strongly related to error correction for both younger and older adults. Confidence alone played little unique role in error correction after controlling for the role of prior knowledge. These data demonstrate that prior knowledge largely predicts error correction and suggests that both older and younger adults can use their prior knowledge to effectively correct errors in memory.

  15. Neurocognitive and Behavioral Outcomes of Younger Siblings of Children with Autism Spectrum Disorder at Age Five

    Science.gov (United States)

    Warren, Zachary E.; Foss-Feig, Jennifer H.; Malesa, Elizabeth E.; Lee, Evon Batey; Taylor, Julie Lounds; Newsom, Cassandra R.; Crittendon, Julie; Stone, Wendy L.

    2012-01-01

    Later-born siblings of children with Autism Spectrum Disorders (ASD) are at increased risk for ASD as well as qualitatively similar traits not meeting clinical cutoffs for the disorder. This study examined age five neurocognitive and behavioral outcomes of 39 younger siblings of children with ASD (Sibs-ASD) and 22 younger siblings of typically…

  16. Emotion in younger and older adults: retrospective and prospective associations with sleep and physical activity.

    Science.gov (United States)

    Ready, Rebecca E; Marquez, David X; Akerstedt, Anna

    2009-01-01

    Older adults may have superior emotion regulation skills than younger adults and the authors suggest that as emotion regulation capacities increase with age, emotions may be less swayed by external events or even by internal traits. The current retrospective and prospective study further tested this hypothesis by determining if the emotions of younger adults were more reactive to two behaviors (i.e., physical activity, sleep) than for older adults. Results supported predictions. Specifically, retrospective self-reports and prospective diary data about physical activity and sleep exhibited stronger associations with emotion for younger than older persons. Implications for emotional well-being across the life span are discussed.

  17. Development and evaluation of a hospital-based peer support group for younger individuals with stroke.

    Science.gov (United States)

    Muller, Melissa; Toth-Cohen, Susan; Mulcahey, M J

    2014-07-01

    The incidence of stroke in younger individuals is rising, producing unique challenges due to loss of productive roles and long-term impact in the survivor's life. This paper reports the results of a hospital-based program based on occupational therapy principles that was designed to provide support and education for 13 younger individuals (<65) with stroke. Participants demonstrated improved socialization, healthy coping, and role attainment as measured by the Stroke Impact Scale (SIS), the Community Integration Questionnaire (CIQ), and a member satisfaction questionnaire. Key factors for successful implementation and considerations for future programs to meet the needs of younger adults with stroke are discussed.

  18. Normal reference value of forced vital capacity of Chinese younger women and geographical factors

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Objective To supply a scientific basis for standardizing the normal reference value of forced vital capacity(FVC)of Chinese younger women.Methods We studied the relationship between the normal reference value of 21767 samples of FVC of younger women and eight geographical factors in 157 areas in China.Results It was found that the correlation between geographical factors and the normal reference value of FVC of younger women was quite significant(F=5.884,P=0.000).By adopting the method of mathematical regre...

  19. Decision-making quality of younger and older adults in familiar and unfamiliar domains.

    Science.gov (United States)

    Wayde, Ernest N; Black, Sheila R; Gilpin, Ansley

    2017-03-01

    Age-related differences in purchasing decisions were examined as a function of age and familiarity. On each trial, participants received purchasing options which varied in quality but ultimately cost the same amount of money. On half the trials, participants made decisions about items familiar to younger adults and on the other half of the trials, participants made decisions about products familiar to older adults. The participants' task was to choose the option that provided the best value for the money. We were particularly interested in participants' performance when inferencing was required to select the optimal option from the two choices. Younger adults outperformed older adults in unfamiliar but not familiar domains. It appeared that both younger and older adults used inferencing and elaborative processing to make the best decision in familiar domains but that only younger adults used inferencing and elaborative processing in unfamiliar domains.

  20. Influence of broadcasting on Aggressive Behaviour of Younger School-Aged Children

    OpenAIRE

    RAJNOVÁ, Zuzana

    2011-01-01

    The thesis is aimed at influence of broadcasting on the level of aggressive behaviour of younger school-aged children. The basic concepts are explained in general terms; the basic way aggressive behaviour and mass media can be divided is given; psyche of a younger school-aged child is explained; television violence, its forms and both negative and positive effects and health consequences of excessive television-watching are described and prevention of adverse ffects of TV programmes on childr...

  1. 76 FR 4896 - Call for Candidates

    Science.gov (United States)

    2011-01-27

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ACCOUNTING STANDARDS ADVISORY BOARD Call for Candidates AGENCY: Federal Accounting Standards Advisory Board. ACTION: Notice... Federal Accounting Standards Advisory Board (FASAB) is currently seeking candidates (candidates must...

  2. Appendicitis in Children: Evaluation of the Pediatric Appendicitis Score in Younger and Older Children

    Directory of Open Access Journals (Sweden)

    Martin Salö

    2014-01-01

    Full Text Available Background. This study aimed to evaluate Pediatric Appendicitis Score (PAS, diagnostic delay, and factors responsible for possible late diagnosis in children <4 years compared with older children who were operated on for suspected appendicitis. Method. 122 children, between 1 and 14 years, operated on with appendectomy for suspected appendicitis, were retrospectively analyzed. The cohort was divided into two age groups: ≥4 years (n=102 and <4 years (n=20. Results. The mean PAS was lower among the younger compared with the older patients (5.3 and 6.6, resp.; P=0.005, despite the fact that younger children had more severe appendicitis (75.0% and 33.3%, resp.; P=0.001. PAS had low sensitivity in both groups, with a significantly lower sensitivity among the younger patients. Parent and doctor delay were confirmed in children <4 years of age with appendicitis. PAS did not aid in patients with doctor delay. Parameters in patient history, symptoms, and abdominal examination were more diffuse in younger children. Conclusion. PAS should be used with caution when examining children younger than 4 years of age. Diffuse symptoms in younger children with acute appendicitis lead to delay and to later diagnosis and more complicated appendicitis.

  3. Characteristic muscle activity patterns during gait initiation in the healthy younger and older adults.

    Science.gov (United States)

    Khanmohammadi, Roya; Talebian, Saeed; Hadian, Mohammad Reza; Olyaei, Gholamreza; Bagheri, Hossein

    2016-01-01

    It is thought that gait initiation (GI) might be an optimal task for identifying postural control deficiencies. Thus, the aim of this study was to clarify the strategies adopted by older subjects during this task. 16 healthy younger and 15 healthy older adults participated in the study. Subjects were instructed to begin forward stepping with their dominant limb in response to an auditory stimulus. The mean muscle activity, co-contraction index, and intra-subject coefficients of variation (intra-subject CVs) of dominant limb muscles in different phases of GI were measured. The level of association between the co-contraction index and intra-subject CV of muscles was also explored. This study showed that in the anticipatory phase, the younger group had larger amplitudes and more intra-subject CVs than older the group, particularly for the tibialis anterior muscle. However, the co-contraction index was greater in older subjects relative to younger subjects. During the weight transition phase, tibialis anterior, semitendinosus and vastus lateralis muscles of older adults had a lower amplitude as compared to younger adults. However, during the locomotor phase, the activity of tibialis anterior was greater in comparison to younger adults. Also, during this phase, similar to the anticipatory phase, the co-contraction index between tibialis anterior and gastrocnemius muscles was greater in older subjects relative to younger subjects. Additionally, the larger co-contraction index of some muscles was associated with smaller intra-subject CV. These findings suggest that muscle behaviors are altered with aging and older adults employ different strategies in the different phases of GI as compared to younger adults.

  4. Candidate Prediction Models and Methods

    DEFF Research Database (Denmark)

    Nielsen, Henrik Aalborg; Nielsen, Torben Skov; Madsen, Henrik

    2005-01-01

    This document lists candidate prediction models for Work Package 3 (WP3) of the PSO-project called ``Intelligent wind power prediction systems'' (FU4101). The main focus is on the models transforming numerical weather predictions into predictions of power production. The document also outlines...

  5. Candidate gene prioritization with Endeavour.

    Science.gov (United States)

    Tranchevent, Léon-Charles; Ardeshirdavani, Amin; ElShal, Sarah; Alcaide, Daniel; Aerts, Jan; Auboeuf, Didier; Moreau, Yves

    2016-07-08

    Genomic studies and high-throughput experiments often produce large lists of candidate genes among which only a small fraction are truly relevant to the disease, phenotype or biological process of interest. Gene prioritization tackles this problem by ranking candidate genes by profiling candidates across multiple genomic data sources and integrating this heterogeneous information into a global ranking. We describe an extended version of our gene prioritization method, Endeavour, now available for six species and integrating 75 data sources. The performance (Area Under the Curve) of Endeavour on cross-validation benchmarks using 'gold standard' gene sets varies from 88% (for human phenotypes) to 95% (for worm gene function). In addition, we have also validated our approach using a time-stamped benchmark derived from the Human Phenotype Ontology, which provides a setting close to prospective validation. With this benchmark, using 3854 novel gene-phenotype associations, we observe a performance of 82%. Altogether, our results indicate that this extended version of Endeavour efficiently prioritizes candidate genes. The Endeavour web server is freely available at https://endeavour.esat.kuleuven.be/.

  6. Candidate cave entrances on Mars

    Science.gov (United States)

    Cushing, Glen E.

    2012-01-01

    This paper presents newly discovered candidate cave entrances into Martian near-surface lava tubes, volcano-tectonic fracture systems, and pit craters and describes their characteristics and exploration possibilities. These candidates are all collapse features that occur either intermittently along laterally continuous trench-like depressions or in the floors of sheer-walled atypical pit craters. As viewed from orbit, locations of most candidates are visibly consistent with known terrestrial features such as tube-fed lava flows, volcano-tectonic fractures, and pit craters, each of which forms by mechanisms that can produce caves. Although we cannot determine subsurface extents of the Martian features discussed here, some may continue unimpeded for many kilometers if terrestrial examples are indeed analogous. The features presented here were identified in images acquired by the Mars Odyssey's Thermal Emission Imaging System visible-wavelength camera, and by the Mars Reconnaissance Orbiter's Context Camera. Select candidates have since been targeted by the High-Resolution Imaging Science Experiment. Martian caves are promising potential sites for future human habitation and astrobiology investigations; understanding their characteristics is critical for long-term mission planning and for developing the necessary exploration technologies.

  7. Pioglitazone is equally effective for diabetes prevention in older versus younger adults with impaired glucose tolerance.

    Science.gov (United States)

    Espinoza, Sara E; Wang, Chen-Pin; Tripathy, Devjit; Clement, Stephen C; Schwenke, Dawn C; Banerji, Mary Ann; Bray, George A; Buchanan, Thomas A; Henry, Robert R; Kitabchi, Abbas E; Mudaliar, Sunder; Stentz, Frankie B; Reaven, Peter D; DeFronzo, Ralph A; Musi, Nicolas

    2016-12-01

    To determine the efficacy of pioglitazone to prevent type 2 diabetes in older compared to younger adults with pre-diabetes. Six hundred two participants with impaired glucose tolerance (IGT) were randomized in double blind fashion to placebo or pioglitazone for diabetes prevention in the ACT NOW study (NEJM 364:1104-1115, 2011). Cox proportional hazard regression was used to compare time to development of diabetes over a mean of 2 years between older (≥61 years) and younger participants. We compared effects of pioglitazone versus placebo on metabolic profiles, inflammatory markers, adipokines, β cell function (disposition index), insulin sensitivity (Matsuda index), and body composition by ANOVA. Diabetes incidence was reduced by 85 % in older and 69 % in younger subjects (p = 0.41). β cell function (disposition index) increased by 35.0 % in the older and 26.7 % in younger subjects (p = 0.83). Insulin sensitivity (Matsuda index) increased by 3.07 (5.2-fold) in older and by 2.54 (3.8-fold) in younger participants (p = 0.58). Pioglitazone more effectively increased adiponectin in older versus younger subjects (22.9 ± 3.2 μg/mL [2.7-fold] vs. 12.7 ± 1.4 μg/mL [2.2-fold], respectively; p = 0.04). Younger subjects tended to have a greater increase in whole body fat mass compared to older subjects (3.6 vs. 3.1 kg; p = 0.061). Younger and older subjects had similar decreases in bone mineral density (0.018 ± 0.0071 vs. 0.0138 ± 0.021 g/cm(2)). Younger and older pre-diabetic adults taking pioglitazone had similar reductions in conversion to diabetes and older adults had similar or greater improvements in metabolic risk factors, demonstrating that pioglitazone is useful in preventing diabetes in older adults.

  8. Younger Cousin

    Institute of Scientific and Technical Information of China (English)

    俞鸿霄

    2009-01-01

    虫虫:Welcome back!大家假期过得怎么样啊?一定都很快乐,都玩出了新花样吧!不过,新学期到来了,大家还是收收心,将精力投入到学习中去吧。瞧瞧今天又轮到谁上台展示自我了?哦,原来是来自青海的俞鸿霄同学啊。有请——

  9. Time perspective and social preference in older and younger adults: Effects of self-regulatory fatigue.

    Science.gov (United States)

    Segerstrom, Suzanne C; Geiger, Paul J; Combs, Hannah L; Boggero, Ian A

    2016-09-01

    Socioemotional selectivity theory predicts that when perceived time in life is limited, people will prefer emotionally close social partners over less emotionally rewarding partners. Regulating social choices with regard to time perspective can make the best use of time with regard to well-being. However, doing so may depend on the self-regulatory capacity of the individual. Two studies, 1 with younger adults (N = 101) and 1 with younger (N = 42) and older (N = 39) adults, experimentally tested the effects of time perspective and self-regulatory fatigue on preferences for emotionally close partners and knowledgeable partners. In both studies and across younger and older adults, when self-regulatory fatigue was low, the perception of limited time resulted in a greater preference for close social partners relative to knowledgeable social partners. However, this shift was eliminated by self-regulatory fatigue. In Study 2, when fatigued, younger adults preferred close social partners to knowledgeable partners across time perspectives; older adults preferred close and knowledgeable partners more equally across time perspectives. These findings have implications for social decision-making and satisfaction among people who experience chronic self-regulatory fatigue. They also contradict previous suggestions that only younger adults are susceptible to self-regulatory fatigue. (PsycINFO Database Record

  10. Genotypic characterization and historical perspective of Mycobacterium tuberculosis among older and younger Finns, 2008-2011.

    Science.gov (United States)

    Smit, P W; Haanperä, M; Rantala, P; Couvin, D; Lyytikäinen, O; Rastogi, N; Ruutu, P; Soini, H

    2014-11-01

    The Mycobacterium tuberculosis genotypes obtained from elderly Finns were assessed and compared with those obtained from younger Finns to comprehend the epidemiology of tuberculosis (TB) in Finland. From 2008 to 2011, a total of 1021 M. tuberculosis isolates were characterized by spoligotyping and 15-locus mycobacterial interspersed repetitive units-variable number tandem repeat typing. In total, 733 Finnish-born cases were included in the study, of which 466 (64%) were born before 1945 (older Finns). Of these, 63 (14%) shared an M. tuberculosis genotype with foreign-born or younger Finnish cases (born after 1945), and 59 (13%) shared a genotype with older Finnish cases. Eighty-five per cent had a unique genotypic profile while 70% belonged to T or Haarlem families, suggesting that ongoing transmission is infrequent among young and elderly Finns. Simultaneous reactivation of TB among older Finns was the most likely cause for clustering. As most isolates belonged to Haarlem or T, Finland was most likely affected by a similar TB epidemic at the beginning of the twentieth century as that seen in Sweden and Norway. Younger Finns were significantly more likely to be clustered (56% versus 27%, ptuberculosis isolates from elderly Finns were associated with dominant lineages of the early twentieth century and differed from the heterogeneous lineages found among younger TB patients. Additionally, younger TB patients were more likely to transmit TB than elderly Finns.

  11. GENDER ORIENTATION FORMATION FEATURES OF YOUNGER PUPILS IN THE EDUCATIONAL PROCESS

    Directory of Open Access Journals (Sweden)

    Yulia V. KURBATOVA

    2015-01-01

    Full Text Available In the modern Russian society modernization of education, accompanied by a rethinking, re-evaluating and adopting new values and orientations. Significant changes have affected and General education, in which the system-activity approach is crucial. The subject of study in this paper is the development of gender orientations of younger students in the educational process. In the process of research used complex methods of research: analysis of scientific literature on the research problem, theoretical analysis and synthesis of interview and participant observation. Scientific novelty consists in the fact that the essence of gender identity and the features of its formation in primary school; the pedagogical potential of management of development of gender orientations of younger students in the educational process. Conducted scientific study of the problem of formation of a gender orientations of younger students in the educational process due to the value of a healthy gender identity to the full development of the person. An empirical study of gender identity younger students showed the existence of problems of formation of a gender orientations in the educational process. Most younger students recorded a rigid gender identity. 

  12. Understanding the gap in primary care access and use between teens and younger children.

    Science.gov (United States)

    Burns, Marguerite E; Leininger, Lindsey Jeanne

    2012-10-01

    Primary health care use among teenagers falls short of clinical recommendations and consistently lags behind that of younger children. Using the Medical Expenditure Panel Survey, the authors explore three explanations for this age-related gap: family composition, parental awareness of children's health care needs, and the relative role of predisposing, enabling, and need-based factors for teens and younger children. Teenagers are 64% more likely to have no usual source of care and 25% more likely to have had no health care visit in the prior year relative to younger children. The gap narrows in families with children from both age-groups and among children with special health care needs. The largest disparity in primary care access exists between teens in families with no younger sibling(s) and younger children in families with no teen(s). A resolution to the age-related access gap will likely require understanding of, and intervention into, family-level determinants of poor access.

  13. Automatic Classification of Kepler Planetary Transit Candidates

    OpenAIRE

    McCauliff, Sean D.; Jenkins, Jon M.; Catanzarite, Joseph; Burke, Christopher J.; Coughlin, Jeffrey L.; Twicken, Joseph D.; Tenenbaum, Peter; Seader, Shawn; Li, Jie; Cote, Miles

    2014-01-01

    In the first three years of operation the Kepler mission found 3,697 planet candidates from a set of 18,406 transit-like features detected on over 200,000 distinct stars. Vetting candidate signals manually by inspecting light curves and other diagnostic information is a labor intensive effort. Additionally, this classification methodology does not yield any information about the quality of planet candidates; all candidates are as credible as any other candidate. The torrent of exoplanet disco...

  14. Comparing urban form correlations of the travel patterns of older and younger adults

    DEFF Research Database (Denmark)

    Meza, Maria Josefina Figueroa; Nielsen, Thomas Alexander Sick; Siren, Anu Kristiina

    2014-01-01

    Using disaggregated data from the Danish National Travel Survey conducted between 2006 - 2011, this study compares the travel patterns of older (65 – 84 years of age) and younger (18 – 64 years of age) adults regarding land use, socio-economic conditions and urban structures. The results highlight...... significant differences between travel patterns and their urban form correlates for the older and younger adult populations. Spatial variables such as density and regional accessibility have different and potentially reverse associations with travel among older adults. The car use of older adults...... is not substituted by other modes in high-density settings, as is the case for younger adults. Older adults do not respond to high regional accessibility by reducing distance traveled, but travel longer and are also more likely to continue using a car in high-access conditions. Spatial structural conditions have...

  15. Cardiovascular reactivity of younger and older adults to positive-, negative-, and mixed-emotion cognitive challenge.

    Science.gov (United States)

    Hogan, Michael J; James, Jack E; McCabe, Tadhg R; Kilmartin, Liam; Howard, Siobhán; Noone, Chris

    2012-03-01

    Although aging is associated with progressive increases in blood pressure level, previous research has been inconsistent as to whether older adults show greater or lesser cardiovascular reactivity (CVR) to emotion than do younger adults. There is reason to believe that these inconsistencies could be clarified by examining age-related differences in hemodynamic profile revealed by measuring the pattern of cardiac output and total peripheral resistance associated with changes in blood pressure reactivity. Accordingly, the present study examined the performance, CVR, and hemodynamic profile of younger and older adults during encoding and recognition of word pairs involving four valence types: positive, negative, mixed (positive/negative), and neutral word pairs. Results revealed higher baseline blood pressure, increased CVR characterized by a vascular hemodynamic profile, and more rapid recovery (especially during encoding) for older than for younger participants. Results are discussed in light of research and theory on the relationship between aging and cardiovascular health.

  16. A fall-off in cervical screening coverage of younger women in developed countries

    DEFF Research Database (Denmark)

    Lancucki, L; Fender, M; Koukari, A;

    2010-01-01

    OBJECTIVES: To analyse cervical screening coverage data by age over time in a number of developed countries throughout the world, with specific emphasis on trends for younger women and on age differentials between younger and older women. METHODS: Routinely collected cervical screening statistics...... that generally the gap between coverage of younger women and coverage of older women increased, sometimes dramatically, between the mid-1990s and the mid-2000s. CONCLUSIONS: There is a general trend in developed countries towards lower coverage in young women (25-29 years old). No common underlying cause has...... and survey data were collected on the proportion of women who have undergone cervical screening with cytology in seven countries in the period 1995 to 2005. RESULTS: Data for the 25-29 age group were examined. Coverage fell in most countries, in three by more than 5 percentage points. In two countries while...

  17. Why are low-income teens more likely to lack health insurance than their younger peers?

    Science.gov (United States)

    Leininger, Lindsey Jeanne; Burns, Marguerite E

    2011-01-01

    Low-income teenagers are more likely to lack health insurance than younger children. Using data from the 2006, 2007, and 2008 rounds of the National Health Interview Survey, we examine whether differences between teens and younger children in socioeconomic factors, public health insurance eligibility, and observable family characteristics explain this apparent age-related coverage gap. Somewhat surprisingly, they do not. We find a highly robust age-coverage gradient among poor and near-poor children. Our results suggest the need to examine teen-specific insurance enrollment dynamics, particularly in families with no younger siblings, to optimize the effect of the newly enacted Patient Protection and Affordable Care Act on teens' insurance coverage.

  18. Effects of context expectation on prospective memory performance among older and younger adults.

    Science.gov (United States)

    Kominsky, Terrence K; Reese-Melancon, Celinda

    2017-01-01

    This experiment examined the impact of context expectation on prospective memory (PM) performance among older and younger adults. Participants responded to PM target words embedded in an ongoing lexical decision task (LDT). Older and younger adults performed similarly on the PM task. Regardless of age, PM was significantly better for participants in the correct context expectation condition and significantly worse in the incorrect context expectation condition relative to participants who held no expectations about the context in which targets would appear. Participants' LDT response latencies were used to assess cost of the PM task to the ongoing task. Latencies were discernibly longer in the LDT block where the PM targets were expected compared to the block where they were not expected. The findings provide new information about how context can be used to support PM aging and suggest that contextual information can be equally beneficial for older and younger adults.

  19. Enthalpy screen of drug candidates.

    Science.gov (United States)

    Schön, Arne; Freire, Ernesto

    2016-11-15

    The enthalpic and entropic contributions to the binding affinity of drug candidates have been acknowledged to be important determinants of the quality of a drug molecule. These quantities, usually summarized in the thermodynamic signature, provide a rapid assessment of the forces that drive the binding of a ligand. Having access to the thermodynamic signature in the early stages of the drug discovery process will provide critical information towards the selection of the best drug candidates for development. In this paper, the Enthalpy Screen technique is presented. The enthalpy screen allows fast and accurate determination of the binding enthalpy for hundreds of ligands. As such, it appears to be ideally suited to aid in the ranking of the hundreds of hits that are usually identified after standard high throughput screening.

  20. Leishmaniasis: vaccine candidates and perspectives.

    Science.gov (United States)

    Singh, Bhawana; Sundar, Shyam

    2012-06-06

    Leishmania is a protozoan parasite and a causative agent of the various clinical forms of leishmaniasis. High cost, resistance and toxic side effects of traditional drugs entail identification and development of therapeutic alternatives. The sound understanding of parasite biology is key for identifying novel drug targets, that can induce the cell mediated immunity (mainly CD4+ and CD8+ IFN-gamma mediated responses) polarized towards a Th1 response. These aspects are important in designing a new vaccine along with the consideration of the candidates with respect to their ability to raise memory response in order to improve the vaccine performance. This review is an effort to identify molecules according to their homology with the host and their ability to be used as potent vaccine candidates.

  1. Toward organometallic antischistosomal drug candidates.

    Science.gov (United States)

    Hess, Jeannine; Keiser, Jennifer; Gasser, Gilles

    2015-01-01

    In the recent years, there has been a growing interest in the use of novel approaches for the treatment of parasitic diseases such as schistosomiasis. Among the different approaches used, organometallic compounds were found to offer unique opportunities in the design of antiparasitic drug candidates. A ferrocenyl derivative, namely ferroquine, has even entered clinical trials as a novel antimalarial. In this short review, we report on the studies describing the use of organometallic compounds against schistosomiasis.

  2. The Younger Siblings of Teenage Mothers: A Follow-Up of Their Pregnancy Risk

    OpenAIRE

    East, Patricia L.; Jacobson, Leanne J.

    2001-01-01

    This study followed 243 younger brothers and younger sisters of parenting teens and nonparenting teens across a 1.5-year period. The average age of siblings was 13.6 years at Time 1 and 15 years at Time 2. Relative to other youths, the sisters of parenting teens exhibited a sharp increase in drug and alcohol use and partying behavior across time and had the highest pregnancy rate at Time 2 (15%). The siblings of parenting teens spent 10 hr a week caring for their sisters’ children, and, for g...

  3. Local Medicaid home- and community-based services spending and nursing home admissions of younger adults.

    Science.gov (United States)

    Thomas, Kali S; Keohane, Laura; Mor, Vincent

    2014-11-01

    We used fixed-effect models to examine the relationship between local spending on home- and community-based services (HCBSs) for cash-assisted Medicaid-only disabled (CAMOD) adults and younger adult admissions to nursing homes in the United States during 2001 through 2008, with control for facility and market characteristics and secular trends. We found that increased CAMOD Medicaid HCBS spending at the local level is associated with decreased admissions of younger adults to nursing homes. Our findings suggest that states' efforts to expand HCBS for this population should continue.

  4. Higher cumulative revision rate of knee arthroplasties in younger patients with osteoarthritis.

    Science.gov (United States)

    Harrysson, Ola L A; Robertsson, Otto; Nayfeh, Jamal F

    2004-04-01

    This study was designed to test the hypothesis that younger patients treated for osteoarthritis and similar conditions using total knee arthroplasty and unicompartmental knee arthroplasty have a lower implant survival rate when compared with older patients. Previous studies have been done on a small number of patients and only included the younger patients. In many cases patients treated for rheumatoid arthritis have been included in the studies and exceptional survival rates have been reported. The current study compared the cumulative revision rate of the components in 33,251 patients older than 60 years and 2606 patients younger than 60 years treated with total knee arthroplasty or unicompartmental knee arthroplasty for osteoarthritis or similar conditions. Cox regression was used to compare the risk for revision between the two age groups and between gender and the effect of year of operation. The results showed a higher cumulative revision rate for the group of younger patients in all statistical analyses and the risk ratio for revision was significantly lower for the group of older patients. The risk for revision decreased for both groups when considering the year of surgery. This is probably attributable to better implant components and surgical techniques.

  5. The ontogeny of human point following in dogs: When younger dogs outperform older.

    Science.gov (United States)

    Zaine, Isabela; Domeniconi, Camila; Wynne, Clive D L

    2015-10-01

    We investigated puppies' responsiveness to hand points differing in salience. Experiment 1 compared performance of younger (8 weeks old) and older (12 weeks) shelter pups in following pointing gestures. We hypothesized that older puppies would show better performance. Both groups followed the easy and moderate but not the difficult pointing cues. Surprisingly, the younger pups outperformed the older ones in following the moderate and difficult points. Investigation of subjects' backgrounds revealed that significantly more younger pups had experience living in human homes than did the older pups. Thus, we conducted a second experiment to isolate the variable experience. We collected additional data from older pet pups living in human homes on the same three point types and compared their performance with the shelter pups from Experiment 1. The pups living in homes accurately followed all three pointing cues. When comparing both experienced groups, the older pet pups outperformed the younger shelter ones, as predicted. When comparing the two same-age groups differing in background experience, the pups living in homes outperformed the shelter pups. A significant correlation between experience with humans and success in following less salient cues was found. The importance of ontogenetic learning in puppies' responsiveness to certain human social cues is discussed.

  6. Comparison between surgical outcomes of colorectal cancer in younger and elderly patients

    Institute of Scientific and Technical Information of China (English)

    Longxue Jin; Katsutoshi Kaneko; Norio Inoue; Naoki Sato; Susumu Matsumoto; Hitoshi Kanno; Yuko Hashimoto; Kazuhiro Tasaki; Kinya Sato; Shun Sato

    2011-01-01

    AIM: To compare the outcome of surgical treatment of colorectal adenocarcinoma in elderly and younger patients. METHODS: The outcomes of 122 patients with colorectal adenocarcinoma who underwent surgical treatment between January 2004 and June 2009 were analyzed. The clinicopathological and blood biochemistry data of the younger group (< 75 years) and the elderly group (≥ 75 years) were compared. RESULTS: There were no significant differences between the two groups in operation time, intraoperative blood loss, hospital stay, time to resumption of oral intake, or morbidity. The elderly group had a significantly higher rate of hypertension and cardiovascular disease. levels were significantly lower in the elderly than in the younger group. The serum carcinoembryonic antigen level was lower in the elderly than in the younger group, and there was a significant decreasing trend after the operation in the elderly group. CONCLUSION: The short-term outcomes of surgical treatment in elderly patients with colorectal adenocarcinoma were acceptable. Surgical treatment in elderly patients was considered a selectively effective approach.

  7. The effects of emotional television advertising on older and younger adults

    NARCIS (Netherlands)

    M.J. van der Goot; E.A. van Reijmersdal; M. Kleemans

    2016-01-01

    Understanding older adults’ responses to advertising is vital for the industry because older adults constitute a large and lucrative market: The world population is aging (United Nations, 2012) and consumers of 50 years and older have more disposable income than younger consumers (e.g., Ahmad, 2003;

  8. The effects of emotional television advertising on older and younger adults

    NARCIS (Netherlands)

    Goot, M.J. van der; Reijmersdal, E.A. van; Kleemans, M.

    2016-01-01

    Understanding older adults' responses to advertising is vital for the industry because older adults constitute a large and lucrative market: The world population is aging (United Nations, 2012) and consumers of 50 years and older have more disposable income than younger consumers (e.g., Ahmad, 2003;

  9. Comparable modulation of the late positive potential by emotion regulation in younger and older adults

    NARCIS (Netherlands)

    S.J.E. Langeslag (Sandra); J.W. van Strien (Jan)

    2010-01-01

    textabstractIt has been suggested that emotion regulation improves with aging. Here, we investigated age differences in emotion regulation by studying modulation of the late positive potential (LPP) by emotion regulation instructions. The electroencephalogram of younger (18-26 years) and older (60-7

  10. Changes in cognitive function after carotid endarterectomy in older patients: comparison with younger patients.

    Science.gov (United States)

    Takahashi, Yoshihiro; Ogasawara, Kuniaki; Matsumoto, Yuuki; Kobayashi, Masakazu; Yoshida, Kenji; Kubo, Yoshitaka; Beppu, Takaaki; Murakami, Toshiyuki; Nanba, Takamasa; Ogawa, Akira

    2013-01-01

    Objective and subjective assessments of changes in cognition after carotid endarterectomy (CEA) were compared between older patients (≥76 years old) and younger patients (cognitive assessment by a neurosurgeon and the patient's next of kin, and neuropsychological testing (five parameters) before and after surgery. Of 37 older patients studied, 4 (11%), 28 (75%), and 5 (14%) patients were defined as having subjectively improved, unchanged, and impaired cognition, respectively, following surgery. Differences in test scores (postoperative test score - preoperative test score: Δ score) in all neuropsychological tests were significantly lower in the older patients than in the 213 younger patients. The Δ score was able to statistically differentiate older patients with subjectively improved, unchanged, and impaired cognition after surgery. Receiver operating characteristic analysis showed that the Δ score cut-off point for detecting subjective improvement (upper cut-off point) and impairment (lower cut-off point) in cognition after surgery in older patients was identical to the mean or the mean +0.5 standard deviation (SD) and the mean -1.5 SD or the mean -1 SD, respectively, of the control value obtained from normal subjects. The upper and lower cut-off points were lower and higher, respectively, than those in younger patients. In conclusion, although neuropsychological test scores reflect the subjective assessment of postoperative change in cognition in older patients, the optimal cut-off points for the test scores to detect subjective improvement and impairment in cognition after CEA are different in older patients compared with younger patients.

  11. Immigrant Girls as Caregivers to Younger Siblings: A Transnational Feminist Analysis

    Science.gov (United States)

    Lee, Jo-Anne; Pacini-Ketchabaw, Veronica

    2011-01-01

    This article employs a transnational feminist lens to examine the experiences of racialised immigrant girls who provide care for their younger siblings. The article draws on findings from a participatory action research study in Victoria, British Columbia, Canada to examine the role that immigrant girls' caregiving practices play in transnational…

  12. Autologous transplantation and management of younger patients with mantle cell lymphoma

    DEFF Research Database (Denmark)

    Geisler, Christian H

    2012-01-01

    and molecular remission in younger patients with MCL, is now within reach, based on an integrated approach of intensive AraC containing immunochemotherapy with or without subsequent ASCT, and post-treatment maintenance with rituximab or lenalidomide are now being investigated. Such an integrated approach might...

  13. Predicting Spanking of Younger and Older Children by Mothers and Fathers.

    Science.gov (United States)

    Day, Randal D.; Peterson, Gary W.; McCracken, Coleen

    1998-01-01

    Parents' characteristics that influence the incidence of spanking are investigated. Differences between boys and girls, mothers and fathers, older and younger children, Black and White, and married versus single women, as well as attributes of the child, the parent, and the social context are explored using multiple regression analysis. Profiles…

  14. Mistakes as Stepping Stones: Effects of Errors on Episodic Memory among Younger and Older Adults

    Science.gov (United States)

    Cyr, Andrée-Ann; Anderson, Nicole D.

    2015-01-01

    The memorial costs and benefits of trial-and-error learning have clear pedagogical implications for students, and increasing evidence shows that generating errors during episodic learning can improve memory among younger adults. Conversely, the aging literature has found that errors impair memory among healthy older adults and has advocated for…

  15. Motivating Millennials: Improving Practices in Recruiting, Retaining, and Motivating Younger Library Staff

    Science.gov (United States)

    Smith, Sara D.; Galbraith, Quinn

    2012-01-01

    Working with younger staff and student employees can be a challenge for library supervisors in a multigenerational workplace. Because members of the Millennial Generation have different work expectations, managers need to adjust to best meet their needs. By surveying its five hundred student employees, Brigham Young University's Harold B. Lee…

  16. Employment Status and Perceived Health Status in Younger and Older People with Multiple Sclerosis

    Science.gov (United States)

    Krokavcova, Martina; Nagyova, Iveta; Rosenberger, Jaroslav; Gavelova, Miriam; Middel, Berrie; Gdovinova, Zuzana; Groothoff, Johan W.; van Dijk, Jitse P.

    2012-01-01

    This study explores how employment is associated with perceived physical and mental health status in people with multiple sclerosis (MS) adjusted for sociodemographic and clinical variables stratified by age. The sample consisted of 184 MS patients divided into a younger (less than 45 years) and an older (greater than or equal to 45 years) age…

  17. The Changing Construct of Computer Anxiety for Younger and Older Adults.

    Science.gov (United States)

    Dyck, Jennifer L.; Gee, Nancy R.; Smither, Janan Al-Awar

    1998-01-01

    A revalidation of a previously developed computer anxiety scale indicated changes in the factor structure for younger and older adults. Two factors emerged--"Direct Involvement" and "Indirect Involvement" with computers--as compared with the previous "General Computer Anxiety" and "Equipment Anxiety" factors, suggesting that the construct of…

  18. Hormone therapy affects plasma measures of factor VII-activating protease in younger postmenopausal women

    DEFF Research Database (Denmark)

    Mathiasen, Jørn Sidelmann; Skouby, S.O.; Vitzthum, F.;

    2010-01-01

    Objectives Current reviews indicate that hormone therapy (HT) has a protective role in coronary heart disease (CHD) in younger postmenopausal women, whereas HT contributes to CHD in older women Factor VII-activating protease (FSAP) is a serine protease that accumulates in unstable atherosclerotic...

  19. Longitudinal Links between Older Sibling Features and Younger Siblings' Academic Adjustment during Early Adolescence

    Science.gov (United States)

    Bouchey, Heather A.; Shoulberg, Erin K.; Jodl, Kathleen M.; Eccles, Jacquelynne S.

    2010-01-01

    This study investigated prospective relations between older siblings' support and academic engagement and younger siblings' academic adjustment from 7th to post-8th grade. The study was unique in that it incorporated a sample of both African American and European American adolescents. Also investigated was the extent to which the gender…

  20. Family and Friend Relationships among Older and Younger Adults: Interaction Motivation, Mood, and Quality.

    Science.gov (United States)

    O'Connor, Brian P.

    1995-01-01

    In a study of relationships and life satisfaction, 82 independently-living older adults and 91 younger adults completed measures of their relationships with family and friends. For elderly people, the quality of relationships with their friends was more important than the quality of relationships with their children. The discussion focuses on how…

  1. Discharge home after acute stroke : Differences between older and younger patients

    NARCIS (Netherlands)

    Dutrieux, Roy D.; Van Eijk, Monica; Van Mierlo, Marloes L.; Van Heugten, Caroline M.; Visser-Meily, Johanna M A; Achterberg, Wilco P.

    2016-01-01

    Objective: To identify determinants for discharge destination of older (≥ 70 years) and younger (<70 years) acute stroke patients. Design: Multicentre prospective cohort. Patients: A total of 395 patients, within 7 days of clinically evaluated stroke, were included from 6 hospital stroke units. Meth

  2. With Eyes of Equality: Older and Younger Students Learn in a Community College Senior Program.

    Science.gov (United States)

    Heinrich, June Sark

    In contrast to many senior education programs, the senior program at Triton College (TC) has as one of its aims bringing together younger and older students in both noncredit and credit courses without neglecting the need and desire of many older adults to learn in their own age group. The term "older students" is loosely defined at the college,…

  3. Connecting Younger Second-Language Learners and Older Bilinguals: Interconnectedness and Social Inclusion

    Science.gov (United States)

    Clyne, Michael; Cordella, Marisa; Schüpbach, Doris; Maher, Brigid

    2013-01-01

    This article reports on an inter-generational inter-cultural pilot project carried out in suburban Melbourne which supports the second-language acquisition of younger people and enhances the social inclusion of older people of migrant background. The article begins with an outline of the multilingual context in which the project is based. The…

  4. Suicide in patients suffering from late-life anxiety disorders; a comparison with younger patients

    NARCIS (Netherlands)

    Oude Voshaar, R.C.; Veen, D.C. van der; Kapur, N.; Hunt, I.; Williams, A.; Pachana, N.A.

    2015-01-01

    BACKGROUND: Anxiety disorders are assumed to increase suicide risk, although confounding by comorbid psychiatric disorders may be one explanation. This study describes the characteristics of older patients with an anxiety disorder who died by suicide in comparison to younger patients. METHOD: A 15-y

  5. Suicide in patients suffering from late-life anxiety disorders; a comparison with younger patients

    NARCIS (Netherlands)

    Oude Voshaar, R. C.; van der Veen, D.C.; Kapur, N.; Hunt, I.; Williams, A.; Pachana, N. A.

    2015-01-01

    Background: Anxiety disorders are assumed to increase suicide risk, although confounding by comorbid psychiatric disorders may be one explanation. This study describes the characteristics of older patients with an anxiety disorder who died by suicide in comparison to younger patients. Method: A 15-y

  6. Feelings towards Older vs. Younger Adults: Results from the European Social Survey

    Science.gov (United States)

    Ayalon, Liat

    2013-01-01

    The study evaluated the association of modernization (at the macro/societal-level) and modernity (at the micro/individual-level) with feelings towards older vs. younger adults. Analysis was based on the fourth wave of the European Social Survey, which includes a rotated module on ageism. The sample consisted of 28 countries and a total of 54,988…

  7. The correlation between a passion for computer games and the school performance of younger schoolchildren.

    Directory of Open Access Journals (Sweden)

    Maliy D.V.

    2015-07-01

    Full Text Available Today computer games occupy a significant place in children’s lives and fundamentally affect the process of the formation and development of their personalities. A number of present-day researchers assert that computer games have a developmental effect on players. Others share the point of view that computer games have negative effects on the cognitive and emotional spheres of a child and claim that children with low self-esteem who neglect their schoolwork and have difficulties in communication are particularly passionate about computer games. This article reviews theoretical and experimental pedagogical and psychological studies of the nature of the correlation between a passion for computer games and the school performance of younger schoolchildren. Our analysis of foreign and Russian psychology studies regarding the problem of playing activities mediated by information and computer technologies allowed us to single out the main criteria for children’s passion for computer games and school performance. This article presents the results of a pilot study of the nature of the correlation between a passion for computer games and the school performance of younger schoolchildren. The research involved 32 pupils (12 girls and 20 boys aged 10-11 years in the 4th grade. The general hypothesis was that there are divergent correlations between the passion of younger schoolchildren for computer games and their school performance. A questionnaire survey administered to the pupils allowed us to obtain information about the amount of time they devoted to computer games, their preferences for computer-game genres, and the extent of their passion for games. To determine the level of school performance we analyzed class registers. To establish the correlation between a passion for computer games and the school performance of younger schoolchildren, as well as to determine the effect of a passion for computer games on the personal qualities of the children

  8. Category learning strategies in younger and older adults: Rule abstraction and memorization.

    Science.gov (United States)

    Wahlheim, Christopher N; McDaniel, Mark A; Little, Jeri L

    2016-06-01

    Despite the fundamental role of category learning in cognition, few studies have examined how this ability differs between younger and older adults. The present experiment examined possible age differences in category learning strategies and their effects on learning. Participants were trained on a category determined by a disjunctive rule applied to relational features. The utilization of rule- and exemplar-based strategies was indexed by self-reports and transfer performance. Based on self-reported strategies, the frequencies of rule- and exemplar-based learners were not significantly different between age groups, but there was a significantly higher frequency of intermediate learners (i.e., learners not identifying with a reliance on either rule- or exemplar-based strategies) in the older than younger adult group. Training performance was higher for younger than older adults regardless of the strategy utilized, showing that older adults were impaired in their ability to learn the correct rule or to remember exemplar-label associations. Transfer performance converged with strategy reports in showing higher fidelity category representations for younger adults. Younger adults with high working memory capacity were more likely to use an exemplar-based strategy, and older adults with high working memory capacity showed better training performance. Age groups did not differ in their self-reported memory beliefs, and these beliefs did not predict training strategies or performance. Overall, the present results contradict earlier findings that older adults prefer rule- to exemplar-based learning strategies, presumably to compensate for memory deficits. (PsycINFO Database Record

  9. Old and Unemployable? How Age‐Based Stereotypes Affect Willingness to Hire Job Candidates

    Science.gov (United States)

    Swift, Hannah J.; Drury, Lisbeth

    2016-01-01

    Across the world, people are required, or want, to work until an increasingly old age. But how might prospective employers view job applicants who have skills and qualities that they associate with older adults? This article draws on social role theory, age stereotypes and research on hiring biases, and reports three studies using age‐diverse North American participants. These studies reveal that: (1) positive older age stereotype characteristics are viewed less favorably as criteria for job hire, (2) even when the job role is low‐status, a younger stereotype profile tends to be preferred, and (3) an older stereotype profile is only considered hirable when the role is explicitly cast as subordinate to that of a candidate with a younger age profile. Implications for age‐positive selection procedures and ways to reduce the impact of implicit age biases are discussed. PMID:27635102

  10. Screw fixation for atlantoaxial dislocation related to Down syndrome in children younger than 5 years.

    Science.gov (United States)

    Ito, Kenyu; Imagama, Shiro; Ito, Zenya; Ando, Kei; Kobayashi, Kazuyoshi; Hida, Tetsuro; Ishikawa, Yoshimoto; Ishiguro, Naoki

    2017-01-01

    The aim of this study was to present cases of upper cervical fixation in Down syndrome patients younger than 5 years. In two cases, C1 lateral mass screws were installed. However, owing to the irreducible atlantoaxial dislocation, the screw backed out and fractured. Therefore, O-C2 fusion was performed. Furthermore, C2 bilateral lamina screws were added to the C2 pedicle screw for reinforcement. C1-C2 fusion is an option for Down syndrome patients younger than 5 years with atlantoaxial dislocation, when the dislocation is reducible. If the dislocation is irreducible, or the implant cannot be firmly secured, the fixation range should be expanded to O-C2 or below.

  11. Breast cancer in younger women: effects on interpersonal and family relations.

    Science.gov (United States)

    Northouse, L L

    1994-01-01

    Although breast cancer can have a stressful impact on women of all ages, young women may be particularly vulnerable to the negative effects of the disease. Based on a developmental perspective, this article reviews studies on the emotional impact of breast cancer on young women, their spouses, children, and the marital relationship. Studies indicate that younger women experience more emotional distress than older women, although the inverse relationship between age and emotional distress is not consistent across all studies. Although age does not appear to have a direct relationship to husbands' adjustments, younger husbands reported more problems carrying out domestic roles and a greater number of life stresses than older husbands. Studies on the impact of breast cancer on children are limited in number and scope but indicate that the effects of breast cancer vary according to the developmental level of the child. Directions for further research on young women and their families are suggested.

  12. Younger and Older learners'Advantages on Language Acquisition in Different Learning Settings

    Institute of Scientific and Technical Information of China (English)

    赖信含

    2015-01-01

    The question of whether, and how, age affects L2 outcomes has been a major issue in SLA for several decades, and a number of recent publications provide reviews from different points of view. The author has made a comprehensive survey on the researches on the relationship between age and attainment in second language acquisition. Based on age differences theory, the author agrees the opinion that younger learners are more successful in informal and naturalistic L2 learning contexts, and older learners are more successful in formal instructional settings. Then, the younger learners' and older learners' advantages are discussed and put into contrastive analysis. Therefore, in second language teaching and learning, it is necessary to exert the learning advantages of different age groups, have a specific focus on listening, speaking, reading and writing, select teaching strategies suitable for different ages, and make a scientific teaching and learning plan.

  13. Global Coherence in Younger and Older Adults: Influence of Cognitive Processes and Discourse Type

    Science.gov (United States)

    Wright, Heather Harris; Koutsoftas, Anthony D.; Capilouto, Gilson J.; Fergadiotis, Gerasimos

    2013-01-01

    The purpose of the present research was to examine the influence of cognitive processes on discourse global coherence ability measured across different discourse tasks and collected from younger (n = 40; 20–39 y.o.) and older (n = 40; 70–87 y.o.) cognitively healthy adults. Study participants produced oral language samples in response to five commonly used discourse elicitation tasks and they were analyzed for maintenance of global coherence. Participants also completed memory and attention measures. Group differences on the global coherence scale were found for only one type of discourse – recounts. Across discourse elicitation tasks the lowest global coherence scores were found for recounts compared to the other discourse elicitation tasks. The influence of cognitive processes on maintenance of global coherence differed for the two age groups. For the younger group, there were no observed significant relationships. For the older group, cognitive measures were related to global coherence of stories and procedures. PMID:23656430

  14. Loss of control eating disorder in children age 12 years and younger: proposed research criteria.

    Science.gov (United States)

    Tanofsky-Kraff, Marian; Marcus, Marsha D; Yanovski, Susan Z; Yanovski, Jack A

    2008-08-01

    Binge eating is common in middle childhood (6-12 years) and often presents in concert with disordered eating attitudes, emotional distress, overweight and adiposity. Binge eating is also predictive of excessive weight gain and is associated with energy intake. However, few children meet DSM-IV-TR criteria for binge eating disorder, thereby making treatment recommendations a challenge. We propose criteria for a new diagnosis, Loss of Control Eating Disorder in Children age 12 years and younger, for further study. The criteria put forward are a revision of Marcus and Kalarchian's [Marcus, M.D., & Kalarchian, M.A. (2003). Binge eating in children and adolescents. International Journal of Eating Disorders, 34 Suppl, S47-S57.] provisional binge eating disorder research criteria for children 14 years and younger, and are based upon the evolving literature in children with binge and loss of control eating episodes. A rationale for the new criteria set is provided, and future research directions are proposed.

  15. Below-baseline suppression of competitors during interference resolution by younger but not older adults.

    Science.gov (United States)

    Healey, M Karl; Ngo, K W Joan; Hasher, Lynn

    2014-01-01

    Resolving interference from competing memories is a critical factor in efficient memory retrieval, and several accounts of cognitive aging suggest that difficulty resolving interference may underlie memory deficits such as those seen in the elderly. Although many researchers have suggested that the ability to suppress competitors is a key factor in resolving interference, the evidence supporting this claim has been the subject of debate. Here, we present a new paradigm and results demonstrating that for younger adults, a single retrieval attempt is sufficient to suppress competitors to below-baseline levels of accessibility even though the competitors are never explicitly presented. The extent to which individual younger adults suppressed competitors predicted their performance on a memory span task. In a second experiment, older adults showed no evidence of suppression, which supports the theory that older adults' memory deficits are related to impaired suppression.

  16. Typography manipulations can affect priming of word stem completion in older and younger adults.

    Science.gov (United States)

    Gibson, J M; Brooks, J O; Friedman, L; Yesavage, J A

    1993-12-01

    The experiments reported here investigated whether changes of typography affected priming of word stem completion performance in older and younger adults. Across all experiments, the typeface in which a word appeared at presentation either did or did not match that of its 3-letter stem at test. In Experiment 1, no significant evidence of a typography effect was found when words were presented with a sentence judgment or letter judgment task. However, subsequent experiments revealed that, in both older and younger adults, only words presented with a syllable judgment task gave rise to the typography effect (Experiments 2-4). Specifically, performance was greater, when the presentation and test typeface matched than when they did not. Experiment 5, which used stem-cued recall, did not reveal a difference between syllable and letter judgment tasks. These findings highlight the complex nature of word stem completion performance.

  17. Perceptions of younger single adults as a function of their gender and number of children.

    Science.gov (United States)

    Sommer, Shannon; Plumm, Karyn M; Terrance, Cheryl A; Tubré, Travis

    2013-01-01

    Research suggests that children may interfere with single parents' romantic experiences. Although both male and female single parents face these challenges, they have stronger associations with the romantic satisfaction of single mothers as compared to single fathers. The two current studies examined aspects of attractiveness and dating across various dimensions for both younger single women and men, with and without children. Results of Study 1 indicated interactive effects of target gender and parental status on perceptions of both attractiveness and dating potential. Results of Study 2 indicated differential ratings on multiple dimensions (i.e., attractiveness, stress, motivation for dating, and positive qualities) of younger single adults on the basis of gender, parental status, and the number of children single parents were reported as having. Implications for importance of social support and difficulty of repartnering are discussed.

  18. Expressive Suppression and Enhancement During Music-Elicited Emotions in Younger and Older Adults

    Directory of Open Access Journals (Sweden)

    Sandrine eVieillard

    2015-02-01

    Full Text Available When presented with emotional visual scenes, older adults have been found to be equally capable to regulate emotion expression as younger adults, corroborating the view that emotion regulation skills are maintained or even improved in later adulthood. However, the possibility that gaze direction might help achieve an emotion control goal has not been taken into account, raising the question whether the effortful processing of expressive regulation is really spared from the general age-related decline. Since it does not allow perceptual attention to be redirected away from the emotional source, music provides a useful way to address this question. In the present study, affective, behavioral and physiological consequences of free expression of emotion, expressive suppression and expressive enhancement were measured in 31 younger and 30 older adults while they listened to positive and negative musical excerpts. The main results indicated that compared to younger adults, older adults reported experiencing less emotional intensity in response to negative music during the free expression of emotion condition. No age difference was found in the ability to amplify or reduce emotional expressions. However, an age-related decline in the ability to reduce the intensity of emotional state and an age-related increase in physiological reactivity were found when participants were instructed to suppress negative expression. Taken together, the current data support previous findings suggesting an age-related change in response to music. They also corroborate the observation that older adults are as efficient as younger adults at controlling behavioral expression. But most importantly, they suggest that when faced with auditory sources of negative emotion, older age does not always confer a better ability to regulate emotions.

  19. Superior recognition performance for happy masked and unmasked faces in both younger and older adults.

    Directory of Open Access Journals (Sweden)

    Joakim eSvard

    2012-11-01

    Full Text Available In the aging literature it has been shown that even though emotion recognition performance decreases with age, the decrease is less for happiness than other facial expressions. Studies in younger adults have also revealed that happy faces are more strongly attended to and better recognized than other emotional facial expressions. Thus, there might be a more age independent happy face advantage in facial expression recognition. By using a backward masking paradigm and varying stimulus onset asynchronies (17–267 ms the temporal development of a happy face advantage, on a continuum from low to high levels of visibility, was examined in younger and older adults. Results showed that across age groups, recognition performance for happy faces was better than for neutral and fearful faces at durations longer than 50 ms. Importantly, the results showed a happy face advantage already during early processing of emotional faces in both younger and older adults. This advantage is discussed in terms of processing of salient perceptual features and elaborative processing of the happy face. We also investigate the combined effect of age and neuroticism on emotional face processing. The rationale was previous findings of age related differences in physiological arousal to emotional pictures and a relation between arousal and neuroticism. Across all durations, there was an interaction between age and neuroticism, showing that being high in neuroticism might be disadvantageous for younger, but not older adults’ emotion recognition performance during arousal enhancing tasks. These results indicate that there is a relation between aging, neuroticism, and performance, potentially related to physiological arousal.

  20. Food consumption of children younger than 6 years according to the degree of food processing

    Directory of Open Access Journals (Sweden)

    Ediana Volz Neitzke Karnopp

    Full Text Available Abstract: Objective: To evaluate food intake according to the degree of processing, stratified by family income and age, in a representative sample of children younger than 6 years in the city of Pelotas, RS, Brazil. Methods: Cross-sectional population-based study carried out with 770 children aged 0-72 months of age living in the urban area of Pelotas. The dietary intake of children was assessed by 24-h recall administered to mothers or guardians. The energy intake was estimated and each food item was classified according to the food processing degree. Food consumption was stratified by age (younger than 24 months; 24 months or older and associations between quintiles of family income and relative contribution of each food to total energy were performed by linear regression. The Wald test was applied to test linear trend across groups. Results: The mean energy intake was 1725.7 kcal/day. The mean contribution of processed and ultraprocessed foods was 19.7% among children younger than 24 months and 37% in those aged 24 months or older, while the mean consumption of natural and minimally processed food was 61% and 44%, respectively. Among children aged 24 months or older, a greater consumption of canned foods, cheese and sweets was observed as family income quintiles increased, while breads were more consumed by those children belonging to the lower income quintiles. Conclusion: A high caloric contribution of ultraprocessed foods in detriment to a lower consumption of natural and minimally processed foods was observed in the diet of children younger than 6 years.

  1. Positive outcomes enhance incidental learning for both younger and older adults

    Directory of Open Access Journals (Sweden)

    Mara eMather

    2011-11-01

    Full Text Available Previous studies suggest that memory encoding is enhanced when people are anticipating a potential reward, consistent with the idea that dopaminergic systems that respond to motivationally relevant information also enhance memory for that information. In the current study, we examined how anticipating and receiving rewards versus losses affect incidental learning of information. In addition, we compared the modulatory effects of reward anticipation and outcome on memory for younger and older adults. Forty-two younger (aged 18 - 33 years and 44 older (aged 66 - 92 years adults played a game involving pressing a button as soon as they saw a target. Gain trials began with a cue that they would win $.25 if they pressed the button fast enough, loss trials began with a cue that they would avoid losing $.25 if they pressed the button fast enough, and no-outcome trials began with a cue indicating no monetary outcome. The target was a different photo object on each trial (e.g., balloon, dolphin and performance outcomes were displayed after the photo disappeared. Both younger and older adults recalled and recognized pictures from trials with positive outcomes (either rewarding or loss avoiding better than from trials with negative outcomes. Positive outcomes were associated with not only enhanced memory for the picture just seen in that trial, but also with enhanced memory for the picture shown on the next two trials. Although anticipating a reward also enhanced incidental memory, this effect was seen only in recognition memory of positive pictures and was a smaller effect than the outcome effect. The fact that older adults showed similar incidental memory effects of reward anticipation and outcome as younger adults suggests that reward-memory system interactions remain intact in older age.

  2. The issues of the intellectual and cognitive activity stimulation of younger pupils

    Directory of Open Access Journals (Sweden)

    Repko I.P.

    2012-02-01

    Full Text Available Some means of stimulating the intellectual and cognitive activity of younger pupils are considered: the creation of favourable educational environment (organization of the pedagogically rational dialogue with the children; using the ways of intellectual and emotional stimulating of the pupils, the use of active teaching methods and form (methods of empathy and figurative vision, didactical games, discussions, conducting of the non standard lessons est., personality-oriented evaluation of the study-cognitive activity of pupils.

  3. Action prediction in younger versus older adults: neural correlates of motor familiarity.

    Directory of Open Access Journals (Sweden)

    Nadine Diersch

    Full Text Available Generating predictions during action observation is essential for efficient navigation through our social environment. With age, the sensitivity in action prediction declines. In younger adults, the action observation network (AON, consisting of premotor, parietal and occipitotemporal cortices, has been implicated in transforming executed and observed actions into a common code. Much less is known about age-related changes in the neural representation of observed actions. Using fMRI, the present study measured brain activity in younger and older adults during the prediction of temporarily occluded actions (figure skating elements and simple movement exercises. All participants were highly familiar with the movement exercises whereas only some participants were experienced figure skaters. With respect to the AON, the results confirm that this network was preferentially engaged for the more familiar movement exercises. Compared to younger adults, older adults recruited visual regions to perform the task and, additionally, the hippocampus and caudate when the observed actions were familiar to them. Thus, instead of effectively exploiting the sensorimotor matching properties of the AON, older adults seemed to rely predominantly on the visual dynamics of the observed actions to perform the task. Our data further suggest that the caudate played an important role during the prediction of the less familiar figure skating elements in better-performing groups. Together, these findings show that action prediction engages a distributed network in the brain, which is modulated by the content of the observed actions and the age and experience of the observer.

  4. Younger Age Is an Independent Predictor for Poor Survival in Patients with Signet Ring Prostate Carcinoma

    Directory of Open Access Journals (Sweden)

    Jue Wang

    2011-01-01

    Full Text Available Objective. The aim of this study was to examine the epidemiology, natural history, treatment pattern, and predictors of long-term survival of signet ring prostate carcinoma (SRPC patients based on the analysis of the national Surveillance, Epidemiology, and End Results (SEER database. Methods & Results. Between 1980 and 2004, a total of 93 patients with pathologically confirmed SRPC were identified. The mean age was 70±11 years old. 82.8% of the patients had poorly or undifferentiated histology grade. 13.9% patients presented with metastatic disease. The 1-, 3-, and 5-year cancer-specific survival rates were 94.6%, 89.6%, and 83.8%, respectively. Using multivariate Cox proportional hazard model, younger age (40–50 versus age >70 yrs, =.01, advanced tumor stage (distant versus local/regional, =.02, and earlier diagnosis year (before 1995 versus after 1995, =.01 were predictors of worse cancer specific survival. Conclusions. Despite more aggressive cancer therapy, younger SRPC patients had a worse cancer specific survival. This information could be useful when counseling these patients and emphasizes the need for new strategies and molecular-based therapeutic approaches for younger patients with SRPC.

  5. Inertial Sensor Based Analysis of Lie-to-Stand Transfers in Younger and Older Adults.

    Science.gov (United States)

    Schwickert, Lars; Boos, Ronald; Klenk, Jochen; Bourke, Alan; Becker, Clemens; Zijlstra, Wiebren

    2016-08-12

    Many older adults lack the capacity to stand up again after a fall. Therefore, to analyse falls it is relevant to understand recovery patterns, including successful and failed attempts to get up from the floor in general. This study analysed different kinematic features of standing up from the floor. We used inertial sensors to describe the kinematics of lie-to-stand transfer patterns of younger and healthy older adults. Fourteen younger (20-50 years of age, 50% men) and 10 healthy older community dwellers (≥60 years; 50% men) conducted four lie-to-stand transfers from different initial lying postures. The analysed temporal, kinematic, and elliptic fitting complexity measures of transfer performance were significantly different between younger and older subjects (i.e., transfer duration, angular velocity (RMS), maximum vertical acceleration, maximum vertical velocity, smoothness, fluency, ellipse width, angle between ellipses). These results show the feasibility and potential of analysing kinematic features to describe the lie-to-stand transfer performance, to help design interventions and detection approaches to prevent long lies after falls. It is possible to describe age-related differences in lie-to-stand transfer performance using inertial sensors. The kinematic analysis remains to be tested on patterns after real-world falls.

  6. Allograft Anterior Cruciate Ligament Reconstruction in Patients Younger than 25 Years.

    Science.gov (United States)

    Carter, Thomas R; Rabago, Michael T

    2016-05-01

    Purpose The purpose of this study was to evaluate the outcomes for patients younger than 25 years who had anterior cruciate ligament (ACL) reconstructions with allograft tissue. Methods A total of 52 ACL reconstructions performed with fresh-frozen, nonirradiated tibialis or Achilles allografts in active patients younger than 25 years. Outcome evaluations included the International Knee Documentation Committee (IKDC) objective and subjective forms, KT-1000 arthrometry and Lysholm. Results Forty-two patients were available for follow-up at an average follow-up of 65 months (range, 33-99 months). The average age at surgery was 17 years and 7 months (range, 11 years 10 months-24 years 8 months). Objective and subjective data were obtained from 37 patients with 1 requiring revision, and 5 patients had only subjective data. IKDC objective results were 29-A and 5-B. KT-1000 differences were 0 mm for 4 patients, 1 mm for 23, 2 mm for 8, 3 mm for 1, and > 5 mm for 1 patient. The average IKDC subjective score was 90.2 ± 15.0 and average Lysholm score was 90.0 ± 11. Conclusion The result of our study found that using nonirradiated Achilles or tibialis tendon allografts for ACL reconstructions in active patients younger than 25 years can achieve good outcomes, with a low rate of failure.

  7. Goal-setting, self-efficacy, and memory performance in older and younger adults.

    Science.gov (United States)

    West, R L; Thorn, R M

    2001-01-01

    Research in field and laboratory settings has shown that goals lead to improved self-efficacy and performance, especially when individuals also receive positive feedback. The present study extended goal-setting theory to examine self-set goals and feedback in relation to younger and older adults' memory performance and self-efficacy. Following a baseline recall trial, participants completed three shopping list recall trials. Half of the participants were instructed to set goals for the three experimental trials, and half in each goal condition received performance feedback after each trial. Young adults' self-efficacy, clustering, and recall exceeded that of older adults. Goal setting increased self-efficacy for younger but not older adults, and it did not affect performance. Younger adults and participants in the feedback condition increased their goals across trials, as did participants for whom feedback indicated success. These data provide a first look at the motivational impact of feedback and self-set recall goals in memory aging. Additional study is needed to understand the interactive effects of type of feedback, memory task difficulty, and type of goal setting at different ages.

  8. Expiratory flow limitation and operating lung volumes during exercise in older and younger adults.

    Science.gov (United States)

    Smith, Joshua R; Kurti, Stephanie P; Meskimen, Kayla; Harms, Craig A

    2017-02-20

    We determined the effect of aging on expiratory flow limitation (EFL) and operating lung volumes when matched for lung size. We hypothesized that older adults will exhibit greater EFL and increases in EELV during exercise compared to younger controls. Ten older (5M/5W; >60years old) and nineteen height-matched young adults (10M/9W) were recruited. Young adults were matched for%predicted forced vital capacity (FVC) (Y-matched%Pred FVC; n=10) and absolute FVC (Y-matched FVC; n=10). Tidal flow-volume loops were recorded during the incremental exercise test with maximal flow-volume loops measured pre- and post-exercise. Compared to younger controls, older adults exhibited more EFL at ventilations of 26, 35, 51, and 80L/min. The older group had higher end-inspiratory lung volume compared to Y-matched%Pred FVC group during submaximal ventilations. The older group increased EELV during exercise, while EELV stayed below resting in the Y-matched%Pred FVC group. These data suggest older adults exhibit more EFL and increase EELV earlier during exercise compared to younger adults.

  9. Comparing Effects of Intrinsic and Extrinsic Social Values Between Younger and Older Employees.

    Science.gov (United States)

    Yeung, Dannii Y; Fung, Helene H; Chan, Darius K-S

    2016-08-17

    Socioemotional selectivity theory proposes that older adults emphasize emotional goals and interpersonal closeness to a greater extent than do younger adults, suggesting that holding social work-related values (SWVs) may be beneficial to older employees. This project aimed at examining two dimensions of SWVs, intrinsic and extrinsic SWVs, and tested whether age and work situation would moderate their effects on self-rated job performance. A cross-sectional survey (Study 1, N = 357) and a 14-day experience sampling study (Study 2, N = 77) were conducted among Chinese managerial employees. Study 1 showed that the direct effect of intrinsic SWVs on self-rated job performance was stronger in older employees than in younger employees. Study 2 demonstrated that older employees who valued intrinsic SWVs while being in social situations performed much better than when they did not value intrinsic SWVs but being in social situations; however such positive effect was not shown in younger employees. Findings of this project reveal that the effect of SWVs varies across locus of effect (intrinsic versus extrinsic), age, and work situation. Among older employees, the positive effect of intrinsic SWVs is more crucial than that of extrinsic SWVs on self-rated job performance. Findings of this project imply that intrinsically rewarding incentives would be more effective in motivating older employees to reach peak performance.

  10. Teacher Candidates' Communication Skills and Communicator Styles

    OpenAIRE

    Cem ÇUHADAR; Özgür, Hasan; Akgün, Fatma; GÜNDÜZ, Şemseddin

    2015-01-01

    The purpose of this study is to find out the relationship between the communication skills and the communicator styles of teacher candidates. This research was conducted among the senior class students, studying at Trakya University, Faculty of Education in the fall semester of the 2012-2013 academic year. 205 women and 110 men, in a total of 315 teacher candidates participated in the research. As a result, it has been observed that the teacher candidates bear animated/expressive features the...

  11. State-based versus reward-based motivation in younger and older adults.

    Science.gov (United States)

    Worthy, Darrell A; Cooper, Jessica A; Byrne, Kaileigh A; Gorlick, Marissa A; Maddox, W Todd

    2014-12-01

    Recent decision-making work has focused on a distinction between a habitual, model-free neural system that is motivated toward actions that lead directly to reward and a more computationally demanding goal-directed, model-based system that is motivated toward actions that improve one's future state. In this article, we examine how aging affects motivation toward reward-based versus state-based decision making. Participants performed tasks in which one type of option provided larger immediate rewards but the alternative type of option led to larger rewards on future trials, or improvements in state. We predicted that older adults would show a reduced preference for choices that led to improvements in state and a greater preference for choices that maximized immediate reward. We also predicted that fits from a hybrid reinforcement-learning model would indicate greater model-based strategy use in younger than in older adults. In line with these predictions, older adults selected the options that maximized reward more often than did younger adults in three of the four tasks, and modeling results suggested reduced model-based strategy use. In the task where older adults showed similar behavior to younger adults, our model-fitting results suggested that this was due to the utilization of a win-stay-lose-shift heuristic rather than a more complex model-based strategy. Additionally, within older adults, we found that model-based strategy use was positively correlated with memory measures from our neuropsychological test battery. We suggest that this shift from state-based to reward-based motivation may be due to age related declines in the neural structures needed for more computationally demanding model-based decision making.

  12. Septic Arthritis in Infants Younger Than 3 Months: A Retrospective Review.

    Science.gov (United States)

    Bono, Kenneth T; Samora, Julie Balch; Klingele, Kevin E

    2015-09-01

    Septic arthritis in infants is rare and can be difficult to diagnose. This study reviewed a series of patients younger than 3 months to identify factors that may assist in early diagnosis and treatment. A query of records at a large Midwestern pediatric hospital (1994-2010) was performed to identify all patients younger than 3 months at the time of diagnosis. Analysis included birth history, joint involvement, physical examination findings, laboratory results, imaging results, method of treatment, and outcome. In 14 cases (11 boys, 3 girls; mean age at diagnosis, 42.2 days), complete records were available for review. Involved joints included the knee, hip, and shoulder. The most common findings on physical examination were decreased range of motion (100%), tenderness (100%), and swelling (71.4%). Mean temperature was 38.5°C. Mean white blood cell count was 18.5 K/µL, mean erythrocyte sedimentation rate was 48.9 mm/h, and mean C-reactive protein level was 6.1 mg/dL. More than half (57.1%) of joint aspirates grew positive cultures, and 41.7% of blood cultures had positive results. Causative organisms were group B streptococcus, methicillin-sensitive Staphylococcus aureus, Haemophilus influenzae, Streptococcus pneumoniae, Salmonella enterica, and Candida albicans. The most common physical examination findings in infants younger than 3 months with septic arthritis include tenderness, decreased range of motion, and swelling. White blood cell count, C-reactive protein level, and erythrocyte sedimentation rate are likely to be elevated, but these findings should be used in combination with findings on physical examination and radiographic studies to aid in diagnosis.

  13. Diabetes Mellitus and Younger Age Are Risk Factors for Hyperphosphatemia in Peritoneal Dialysis Patients

    Science.gov (United States)

    Imtiaz, Rameez; Hawken, Steven; McCormick, Brendan B.; Leung, Simon; Hiremath, Swapnil; Zimmerman, Deborah L.

    2017-01-01

    Hyperphosphatemia has been associated with adverse outcomes in patients with end stage kidney disease (ESKD). The purpose of this study was to determine risk factors for hyperphosphatemia in ESKD patients treated with peritoneal dialysis (PD). This information will be used to develop a patient specific phosphate binder application to facilitate patient self-management of serum phosphate. Adult PD patients documented their food, beverage, and phosphate binder intake for three days using a dietitian developed food journal. Phosphate content of meals was calculated using the ESHA Food Processor SQL Software (ESHA Research, Salem, UT, USA). Clinic biochemistry tests and an adequacy assessment (Baxter Adequest program) were done. Univariate logistic regression was used to determine predictors of serum phosphate >1.78 mmol/L. A multivariable logistic regression model was then fit including those variables that achieved a significance level of p 1.78 mmol/L). In univariate analysis, the variables associated with an increased risk of hyperphosphatemia with a p-value carbonate (0.08), higher parathyroid serum concentration (0.08), lower phosphate intake (0.03), lower measured glomerular filtration rate (0.15), higher phosphate excretion (0.11), and a higher body mass index (0.15). After multivariable logistic regression analysis, younger age (odds ratio (OR) 0.023 per decade, 95% confidence interval (CI) 0.00065 to 0.455; p = 0.012), presence of diabetes (OR 11.40, 95 CI 2.82 to 61.55; p = 0.0003), and measured GFR (OR 0.052 per mL/min decrease; 95% CI 0.0025 to 0.66) were associated with hyperphosphatemia. Our results support that younger age and diabetes mellitus are significant risk factors for hyperphosphatemia. These findings warrant further investigation to determine the potential mechanisms that predispose younger patients and those with DM to hyperphosphatemia. PMID:28218647

  14. Younger but not older adults benefit from salient feedback during learning

    Directory of Open Access Journals (Sweden)

    Michael eHerbert

    2011-08-01

    Full Text Available Older adults are impaired in reinforcement learning (RL when feedback is partially ambiguous (e.g., Eppinger and Kray, 2011. In this study we examined whether older adults benefit from salient feedback information during learning. We used an electrophysiological approach and investigated 15 younger and 15 older adults with a RL task in which they had to learn stimulus-response associations under two learning conditions. In the positive learning conditions, participants could gain 50 Cents for a correct response but did not gain or lose money (*00 Cent for an incorrect response. In negative learning conditions, they could lose 50 Cents for an incorrect response but did not gain or lose money (*00 Cent for a correct response. As the identical outcome 00 Cent is either better or worse than the alternative outcome depending on the learning condition, this feedback type is ambiguous. To examine the influence of feedback salience we compared this condition with a condition in which positive and negative outcomes were color-coded and thereby clearly separable. The behavioral results indicated that younger adults reached higher accuracy levels under salient feedback conditions. Moreover, the error-related negativity (ERN and the feedback-related negativity (FRN for losses were larger if the good-bad dimension of feedback was salient. Hence, in younger adults salient feedback facilitates the rapid evaluation of outcomes on a good-bad dimension and by this supports learning. In contrast, for older adults we obtained neither behavioral nor electrophysiological effects of feedback salience. The older adults’ performance monitoring system therefore appears less flexible in integrating additional information in this evaluation process.

  15. Histopathological correlation of oral squamous cell carcinoma among younger and older patients

    Directory of Open Access Journals (Sweden)

    Syed Mukith Ur Rahaman

    2014-01-01

    Full Text Available Background: Oral Squamous Cell Carcinoma (OSCC is commonly noted in elder men, when occurring in younger individuals, its aggression and prognosis is questioned due to biased data in literature. Traditionally, various histopathological grading systems have been used for assessing aggression and prognosis of OSCC. However, multifactorial grading of Anneroth et al., is considered effective. Materials and Methods: In this retro-prospective study, files of 75 OSCC patients were retrieved from Oral Pathology Department; among this 50 patients were >40 years and 25 patients were ≤40 years of age. Archival formalin fixed paraffin embedded tissue blocks of these patients were used to prepare hematoxylin and eosin (H and E stained sections for grading OSCC based on Broder′s and Anneroth et al., criteria. Further, recurrence of OSCC among study subjects within 5 years of treatment was evaluated. Chi-square test was used to compare the disease in patients who were >40 years with ≤40 years. Results: Comparison according to Broder′s classification didn′t show any relevant variation. Three of the six parameters and overall grading according to Anneroth et al., criteria showed statistically higher grades of OSCC in the younger age-group; however, there was no significant difference in 5-year recurrence rate. Interpretation and Conclusion: Results of the study are suggestive of aggressive OSCC among young patients when compared to older. Conversely, this aggression didn′t affect the recurrence in younger patients. Further studies on genetics, diet and demographics of patients below 40 years of age affected by OSCC will be of greater value.

  16. An fMRI investigation on simple multiplication in younger and older adults

    Directory of Open Access Journals (Sweden)

    Li SUN

    2014-03-01

    Full Text Available Objective To investigate the cortical activation patterns and their correlation with behavioristics during simple multiplication in Chinese younger and older adults. Methods Functional magnetic resonance imaging (fMRI was performed as healthy younger and older participants resolving arithmetic and control problems. Results Totally 39 right-handed healthy adults were recruited in this study, including 19 (11 females, 8 males younger and 20 (12 females, 8 males older subjects. Age (P = 0.000 was significantly different between 2 groups, and no significant difference was observed in years of education (P = 0.125 and IQ scores (P = 0.921. The accuracy for simple multiplication (P = 0.880 and control task (P = 0.142 were not significantly different between 2 groups, however differences were observed in reaction time for experimental (P = 0.005 and control (P = 0.000 tasks. In younger group, activation in right hemisphere included inferior parietal lobule with an extending to the intraparietal sulcus and superior/middle temporal gyrus, precentral gyrus, premotor cortex and prefrontal cortex. Activation of supramarginal gyrus, angular gyrus, temporal lobe was found in the left. And activation in medial cingulate gyrus, precuneus, parahippocampal gyrus, uncus, and supplementary motor area (SMA was also observed. In older group, supramarginal gyrus, inferior parietal lobule, precentral gyrus, premotor cortex and prefrontal cortex were activated in the right hemisphere. Left angular gyrus, supramarginal gyrus, precentral gyrus, premotor cortex, insula and prefrontal cortex were also activated, as well as cingulate gyrus, paracentral lobule and prefrontal cortex in the medial part. The conjunction analysis of the fMRI data revealed in a distributed network consisting of inferior parietal area, precuneus, precentral/postcentral gyrus and prefrontal lobe, as well as some subcortical areas. Conclusions The major components of the network subserving simple

  17. Malnutrition Among Children Younger Than 5 Years-Old in Conflict Zones of Chiapas, Mexico

    Science.gov (United States)

    Sánchez-Pérez, Héctor Javier; Hernán, Miguel A.; Ríos-González, Adriana; Arana-Cedeño, Marcos; Navarro, Albert; Ford, Douglas; Micek, Mark A.; Brentlinger, Paula

    2007-01-01

    We performed a cross-sectional, community-based survey, supplemented by interviews with community leaders in Chiapas, Mexico, to examine the prevalence and predictors of child malnutrition in regions affected by the Zapatista conflict. The prevalence rates of stunting, wasting, and underweight were 54.1%, 2.9%, and 20.3%, respectively, in 2666 children aged younger than 5 years. Stunting was associated with indigenous ethnicity, poverty, region of residence, and intracommunity division. The results indicate that malnutrition is a serious public health problem in the studied regions. PMID:17194868

  18. Malnutrition among children younger than 5 years-old in conflict zones of Chiapas, Mexico.

    Science.gov (United States)

    Sánchez-Pérez, Héctor Javier; Hernán, Miguel A; Ríos-González, Adriana; Arana-Cedeño, Marcos; Navarro, Albert; Ford, Douglas; Micek, Mark A; Brentlinger, Paula

    2007-02-01

    We performed a cross-sectional, community-based survey, supplemented by interviews with community leaders in Chiapas, Mexico, to examine the prevalence and predictors of child malnutrition in regions affected by the Zapatista conflict. The prevalence rates of stunting, wasting, and underweight were 54.1%, 2.9%, and 20.3%, respectively, in 2666 children aged younger than 5 years. Stunting was associated with indigenous ethnicity, poverty, region of residence, and intracommunity division. The results indicate that malnutrition is a serious public health problem in the studied regions.

  19. Lower extremity venous thrombosis in patients younger than 50 years of age

    Directory of Open Access Journals (Sweden)

    Kreidy R

    2012-03-01

    Full Text Available Raghid Kreidy1, Pascale Salameh2, Mirna Waked31Department of Vascular Surgery, Saint George Hospital, University Medical Center, University of Balamand, 2Laboratory of Clinical and Epidemiological Research, Faculty of Pharmacy, Lebanese University, 3Department of Pulmonary Medicine, Saint George Hospital, University Medical Center, University of Balamand, Beirut, LebanonAim: Lower extremity deep venous thrombosis in the young adult is uncommon and has not been well studied in the literature. The aim of this study is to define risk factors for deep venous thrombosis among patients younger than 50 years of age, to compare them with a control group, and to suggest recommendations for the management and treatment of venous thrombosis in this particular group of patients.Methods: From January 2003 to January 2011, 66 consecutive Lebanese patients (29 males and 37 females younger than 50 years, diagnosed in an academic tertiary-care center with lower extremity deep venous thrombosis by color flow duplex scan, were retrospectively reviewed. Their age varied between 21 and 50 years (mean 38.7 years. The control group included 217 patients (86 males and 131 females older than 50 years (range: 50–96 years; mean 72.9 years.Results: The most commonly reported risk factors in the younger age group were inherited thrombophilia (46.9% compared with 13.8% in the control group; P < 0.001, pregnancy (18.2% compared with 0.5%; P < 0.001, treatment with estrogen drugs (13.6% compared with 2.3%; P = 0.001, and family history of venous thromboembolism (9.1% compared with 3.8%; P = 0.084.Conclusion: Inherited thrombophilia is the most commonly observed risk factor among patients younger than 50 years, with a prevalence of three times more than the control group. Young adults should be screened for thrombophilia even in the presence of transient acquired risk factors. Pregnancy and treatment with estrogen drugs essentially when associated with inherited thrombophilia

  20. High-Resolution Observations of a Binary Black Hole Candidate

    Science.gov (United States)

    Tsai, Chao-Wei; Phillips, Chris; Norris, Ray; Jarrett, Thomas; Emonts, Bjorn; Cluver, Michelle; Eisenhardt, Peter; Stern, Daniel; Assef, Roberto

    2012-10-01

    We propose a 12-hour 2.3 GHz continuum Long Baseline Array (LBA) observation of WISE J2332-5056, a newly discovered supermassive black hole (SMBH) merger candidate that is located in the nearby universe (z = 0.3447). Our recently acquired 9 GHz ATCA map shows unusual radio morphology: a one-sided, smaller (and likely younger) FR-I jet perpendicular to a larger, Doppler-boosted FR-II jet. Follow-up Gemini-S/GMOS spectroscopy of this WISE-selected radio galaxy reveals broad emission lines blue-shifted by > 3,500 km/s with respect to the narrow lines and host galaxy, hallmarks of a dual AGN system. Combined, the optical spectroscopy and radio morphology of this object are strongly suggestive of a black hole merger system. Even in the local universe these systems are extremely difficult to identify; yet the process of supermassive blackhole growth is vital toward understanding galaxy evolution from the early to the current universe. Moreover, nearby merging SMBHs may serve as outstanding targets for gravitational wave studies. The proposed high resolution LBA map, reaching 50 pc resolution at the source redshift will allow us to investigate the SMBH merger scenario hypothesis.

  1. Evaluating historical candidate genes for schizophrenia

    DEFF Research Database (Denmark)

    Farrell, M S; Werge, T; Sklar, P

    2015-01-01

    Prior to the genome-wide association era, candidate gene studies were a major approach in schizophrenia genetics. In this invited review, we consider the current status of 25 historical candidate genes for schizophrenia (for example, COMT, DISC1, DTNBP1 and NRG1). The initial study for 24 of thes...

  2. Exercise holds immediate benefits for affect and cognition in younger and older adults.

    Science.gov (United States)

    Hogan, Candice L; Mata, Jutta; Carstensen, Laura L

    2013-06-01

    Physical activity is associated with improved affective experience and enhanced cognitive processing. Potential age differences in the degree of benefit, however, are poorly understood because most studies examine either younger or older adults. The present study examined age differences in cognitive performance and affective experience immediately following a single bout of moderate exercise. Participants (144 community members aged 19 to 93) were randomly assigned to one of two experimental conditions: (a) exercise (15 min of moderate intensity stationary cycling) or (b) control (15 min completing ratings of neutral IAPS images). Before and after the manipulation, participants completed tests of working memory and momentary affect experience was measured. Results suggest that exercise is associated with increased levels of high-arousal positive affect (HAP) and decreased levels of low-arousal positive affect (LAP) relative to control condition. Age moderated the effects of exercise on LAP, such that younger age was associated with a drop in reported LAP postexercise, whereas the effects of exercise on HAP were consistent across age. Exercise also led to faster RTs on a working memory task than the control condition across age. Self-reported negative affect was unchanged. Overall, findings suggest that exercise may hold important benefits for both affective experience and cognitive performance regardless of age.

  3. Biceps Tenotomy Versus Tenodesis in Active Patients Younger Than 55 Years

    Science.gov (United States)

    Friedman, Jamie L.; FitzPatrick, Jennifer L.; Rylander, Lucas S.; Bennett, Christine; Vidal, Armando F.; McCarty, Eric C.

    2015-01-01

    Background: Proximal biceps pathology is a significant factor in shoulder pain. Surgical treatment options include biceps tenotomy and subpectoral biceps tenodesis. Tenotomy is a simple procedure, but it may produce visible deformity, subjective cramping, or loss of supination strength. Tenodesis is a comparatively technical procedure involving a longer recovery, but it has been hypothesized to achieve better outcomes in younger active patients (Popeye” deformity, compared with 18.2% (4/22) of tenodesis patients. Strength prior to fatiguing exercise was similar between tenodesis and tenotomy for FS (6.9 vs 7.3 lbs; P < .05), EF in neutral (35.4 vs 35.4 lbs), and EF in supination (33.8 vs 34.2 lbs). Strength was not significantly different between groups for isometric strength and endurance measures. Subjective functional outcome measured by the DASH, ASES, and VAS scores were similar between groups. Frequency of complaints of cramping was higher in the tenotomy group (4/20 vs 1/22), and complaints of pain were higher in the tenodesis group (11/22 vs 5/20). Conclusion: Despite increased demands and activity placed on biceps function in a younger population, this study showed no differences in functional and subjective outcome measurements. The choice between biceps tenotomy and tenodesis for pathology of the proximal biceps tendon can continue to be based on surgeon and patient preference. PMID:26535382

  4. Acute diverticulitis in younger patients: Any rationale for a different approach?

    Institute of Scientific and Technical Information of China (English)

    Gil R Faria; Ana B Almeida; Herculano Moreira; Jo(a)o Pinto-de-Sousa; Pedro Correia-da-Silva; Amadeu P Pimenta

    2011-01-01

    AIM: To compare the natural history and course of acute diverticulitis in a younger age group with an older population and to evaluate whether younger patients should be managed differently.METHODS: This study was a retrospective review of 157 patients treated with acute diverticulitis between January 1, 2004 and December 31, 2007. Diverticulitis was stratified according to the Hinchey classification.Patients were divided into 2 populations: group A ≤50 years (n = 31); group B > 50 years (n = 126). Mean patient follow-up was 15 mo.RESULTS: The median age was 60 years. A significantly higher proportion of patients in group B presented with complicated diverticulitis (36.5% vs 12.9%,P = 0.01). Recurrence was more frequent in group A (25.8% vs 11.1%, P = 0.03) and the mean time-torecurrence was shorter (12 mo vs 28 mo, P = 0.26).The most severe recurrent episodes of acute diverticulitis were classified as Hinchey stage Ⅰ and none of the patients required emergency surgery. In multivariate analysis, only age (P = 0.024) was identified as an independent prognostic factor for recurrence.CONCLUSION: Based on the results of this study, we recommend that diverticulitis management should be based on the severity of the disease and not on the age of the patient.

  5. Effects of resistance training on testosterone metabolism in younger and older men.

    Science.gov (United States)

    Ahtiainen, Juha P; Nyman, Kai; Huhtaniemi, Ilpo; Parviainen, Tapani; Helste, Mika; Rannikko, Antti; Kraemer, William J; Häkkinen, Keijo

    2015-09-01

    This study investigated the effects of resistance training (RT) on the metabolism of testosterone (T) in younger (n=5, 28±3yrs.) and older (n=8, 70±2yrs.) men. Experimental heavy resistance exercises (5×10RM leg presses) were performed before and after a 12-month of RT. No age differences were found in the production or metabolic clearance rate of T (determined by stable isotope dilution method), skeletal muscle androgen receptor content or serum LH concentrations due to acute or chronic RT. The T production capacity response to gonadotropin stimulation and the concentrations of the urinary T metabolites (androsterone and etiocholanolone) were lower in the older compared to younger men (p<0.05-0.01). This study further showed that RT may have acute effect on T production and clearance rates, while the exercise-induced increases in serum T appeared to be induced by decreased metabolic clearance rate of T. Attenuated T production capacity and urinary excretion of T metabolites in older men may reflect the known reduction in testicular steroidogenesis upon aging. No changes were observed in T metabolism due to RT indicating a homeostatic stability for this hormone in men of different ages.

  6. Urinary tract infections in febrile infants younger than 8 weeks of age.

    Science.gov (United States)

    Crain, E F; Gershel, J C

    1990-09-01

    In this prospective study of 442 infants younger than 8 weeks of age who attended a pediatric emergency department with temperature greater than or equal to 100.6 degrees F (38.1 degrees C), urinary tract infections (UTIs) were found in 33 patients (7.5%), 2 of whom were bacteremic. Clinical and laboratory data were not helpful for identifying UTIs. Of the 33 patients with UTIs, 32 had urinalyses recorded; 16 were suggestive of a UTI (more than five white blood cells per high-power field or any bacteria present). Of the 16 infants with apparently normal urinalysis results, three had an emergency department diagnosis suggesting an alternative bacterial focus of infection. If the physician had decided on the basis of apparently normal urinalysis results to forgo obtaining a urine culture, more than half of the UTIs would have been missed. Bag-collected specimens were significantly more likely to yield indeterminate urine culture results than either catheter or suprapubic specimens. In addition, uncircumcised males were significantly more likely to have a UTI than circumcised boys. These results suggest that a suprapubic or catheter-obtained urine specimen for culture is a necessary part of the evaluation of all febrile infants younger than 8 weeks of age, regardless of the urinalysis findings or another focus of presumed bacterial infection.

  7. The Difference between Right and Wrong: Accuracy of Older and Younger Adults’ Story Recall

    Directory of Open Access Journals (Sweden)

    Danielle K. Davis

    2015-09-01

    Full Text Available Sharing stories is an important social activity in everyday life. This study used fine-grained content analysis to investigate the accuracy of recall of two central story elements: the gist and detail of socially-relevant stories. Younger (M age = 28.06 and older (M age = 75.03 American men and women (N = 63 recalled fictional stories that were coded for (i accuracy of overall gist and specific gist categories and (ii accuracy of overall detail and specific detail categories. Findings showed no age group differences in accuracy of overall gist or detail, but differences emerged for specific categories. Older adults more accurately recalled the gist of when the event occurred whereas younger adults more accurately recalled the gist of why the event occurred. These differences were related to episodic memory ability and education. For accuracy in recalling details, there were some age differences, but gender differences were more robust. Overall, women remembered details of these social stories more accurately than men, particularly time and perceptual details. Women were also more likely to accurately remember the gist of when the event occurred. The discussion focuses on how accurate recall of socially-relevant stories is not clearly age-dependent but is related to person characteristics such as gender and episodic memory ability/education.

  8. "Feeling younger, walking faster": subjective age and walking speed in older adults.

    Science.gov (United States)

    Stephan, Yannick; Sutin, Angelina R; Terracciano, Antonio

    2015-10-01

    Walking speed is a key vital sign in older people. Given the implications of slower gait speed, a large literature has identified health-related, behavioral, cognitive, and biological factors that moderate age-related decline in mobility. The present study aims to contribute to existing knowledge by examining whether subjective age, how old or young individuals experience themselves to be relative to their chronological age, contributes to walking speed. Participants were drawn from the 2008 and 2012 waves of the Health and Retirement Study (HRS, N = 2970) and the 2011 and 2013 waves of the National Health and Aging Trends Study (NHATS, N = 5423). In both the HRS and the NHATS, linear regression analysis revealed that a younger subjective age was associated with faster walking speed at baseline and with less decline over time, controlling for age, sex, education, and race. These associations were partly accounted for by depressive symptoms, disease burden, physical activity, cognition, body mass index, and smoking. Additional analysis revealed that feeling younger than one's age was associated with a reduced risk of walking slower than the frailty-related threshold of 0.6 m/s at follow-up in the HRS. The present study provides novel and consistent evidence across two large prospective studies for an association between the subjective experience of age and walking speed of older adults. Subjective age may help identify individuals at risk for mobility limitations in old age and may be a target for interventions designed to mitigate functional decline.

  9. Hospital-Acquired Infections in Elderly Versus Younger Patients in an Acute Care Hospital

    Directory of Open Access Journals (Sweden)

    Solis-Hernandez

    2015-11-01

    Full Text Available Background A growing number of elderly patients are hospitalized for various causes and age has been described inconsistently as a risk factor for acquiring nosocomial infections with a subsequent higher mortality rate compared to younger patients. Objectives To describe the incidence, type, and microbiological characteristics of nosocomial infections in elderly and non-elderly patients. Patients and Methods Retrospective analysis of all hospital-acquired infections (HAIs in an academic community hospital. Patients were stratified into two groups: non-elderly (18 - 64 years and elderly (> 65 years. Results A total of 18469 patients were included (108555 hospital days in this study. About 79.6% of HAI were infected non-elderly and 20.3% elderly (P 0.05. Hospital mortality increased with every HAI diagnosed per patient. Conclusions The study showed that HAIs were more frequent in elderly population predominately with respect to VAP and infections by Gram-negative pathogens. Overall mortally was greater in the elderly group although the odds ratio for death was higher in younger patients and increased with every HAI diagnosed.

  10. The role of play in pre-school and younger school age children

    Directory of Open Access Journals (Sweden)

    Kopas-Vukašinović Emina

    2006-01-01

    Full Text Available The paper deals with the importance of play for children’s development and learning in institutionalized preschool education, as well as the opportunities it provides concerning the organization of teaching activities with younger school age children. The paper is based on the theoretical framework emphasizing educational character of children’s play, as a specific form of learning. Notwithstanding occasional attempts within pedagogic theory to deny educational values of children’s play and to emphasize instruction as the only form of systematic learning, contemporary pedagogic views consider play an important part of school education. Learning through play at younger school age helps overcome the discontinuity between preschool and school education. Curriculum subject matter can be covered through carefully selected and prepared play activities within the existing system, providing the support, encouragement and guidance by the adults involved, including their proper knowledge of children’ age-related and psycho-physical characteristics. Play facilitates gradual change over from preschool to school developmental stage, free, spontaneous and creative expression and the development of children’s potential.

  11. How Are Online Health Messages Processed? Using Eye Tracking to Predict Recall of Information in Younger and Older Adults

    NARCIS (Netherlands)

    Bol, Nadine; Van Weert, Julia C M; Loos, Eugène F.; Romano Bergstrom, Jennifer C.; Bolle, Sifra; Smets, Ellen M A

    2016-01-01

    Little research has focused on what precedes the processing of health messages to predict recall of information and whether age matters in this regard. To address this gap, this study investigates the relationship between attention and recall among younger (

  12. Early reconstruction should be considered in younger patients with symptomatic mucoid degeneration of the anterior cruciate ligament

    Directory of Open Access Journals (Sweden)

    Masashi Kusano

    2015-07-01

    Conclusion: Considering the rupture of residual ACL fibres after partial resection and the inevitability of total ACL resection due to degeneration of the entire ligament, ACL reconstruction should be considered in younger patients with symptomatic mucoid degeneration of the ACL.

  13. Results of total joint arthroplasty and joint preserving surgery in younger patients evaluated by alternative outcome measures

    DEFF Research Database (Denmark)

    Klit, Jakob

    2013-01-01

    in younger PAO, TKA, and THA patients our aims were, to explore patient satisfaction, fulfillment of expectations, symptoms of depression, the effect on socioeconomic status, and abilities in sex-life in younger PAO, TKA, and THA patients using PROMs. These alternative endpoints were collected in addition...... to traditional measures of function and HRQoL. Our aims were: 1. To investigate the consequences of TKA, and THA treatment in younger patients in regard to patient satisfaction, expectations, symptoms of depression, socioeconomic effects, and abilities in sex-life. To generate important new information......, important to both patients and surgeons during the decision making process prior to TKA and THA surgery. 2. To create a database that can follow this well-defined high-demanding younger patient group over years, and reveal complications and revision rates due to a higher wear in this group. To support...

  14. Aeroradiometric and photogeologic characterizations Of the younger granites in the north eastern desert, Egypt and implications for mineral deposits

    OpenAIRE

    Abdel Maksoud, M. A. [محمد علي عبدالمقصود; Meguid, Ahmed A. Abdel; Abuzied, Hassan T.; Rakaiby, Magid L.; Bishta, Adel Z.

    1995-01-01

    Photogeologic studies of the younger granites in the North Eastern Desert of Egypt using both aerial photographs and satellite images revealed the separation of three successive phases of younger granites with different photogeological radiometrical and gcologiical characteristics. The first phase plutons (YG1) are charactlerizcd by brown colour, dark tone, fine surface texture, low relief with gentle slopes, elongated ridges, large size (3 km3), and high density -dendritic to parallcd-dra...

  15. Combined oral contraceptives' influence on weight, body composition, height, and bone mineral density in girls younger than 18 years

    DEFF Research Database (Denmark)

    Warholm, Lina; Petersen, Kresten R; Ravn, Pernille

    2012-01-01

    Combined oral contraceptives (COCs) are increasingly used by adolescents. The aim of this review is to investigate the evidence regarding COCs' influence on weight, height and bone mineral density (BMD) in girls younger than 18 years.......Combined oral contraceptives (COCs) are increasingly used by adolescents. The aim of this review is to investigate the evidence regarding COCs' influence on weight, height and bone mineral density (BMD) in girls younger than 18 years....

  16. Undercover Stars Among Exoplanet Candidates

    Science.gov (United States)

    2005-03-01

    events by monitoring the brightness of a very large number of stars over extended time intervals. During the past years, it has also included a search for periodic, very shallow "dips" in the brightness of stars, caused by the regular transit of small orbiting objects (small stars, brown dwarfs [2] or Jupiter-size planets). The OGLE team has since announced 177 "planetary transit candidates" from their survey of several hundred thousand stars in three southern sky fields, one in the direction of the Galactic Centre, another within the Carina constellation and the third within the Centaurus/Musca constellations. The nature of the transiting object can however only be established by subsequent radial-velocity observations of the parent star. The size of the velocity variations (the amplitude) is directly related to the mass of the companion object and therefore allows discrimination between stars and planets as the cause of the observed brightness "dip". A Bonanza of Low-Mass Stars An international team of astronomers [3] has made use of the 8.2-m VLT Kueyen telescope for this work. Profiting from the multiplex capacity of the FLAMES/UVES facility that permits to obtain high-resolution spectra of up to 8 objects simultaneously, they have looked at 60 OGLE transit candidate stars, measuring their radial velocities with an accuracy of about 50 m/s [4]. This ambitious programme has so far resulted in the discovery of five new transiting exoplanets (see, e.g., ESO PR 11/04 for the announcement of two of those). Most of the other transit candidates identified by OGLE have turned out to be eclipsing binaries, that is, in most cases common, small and low-mass stars passing in front of a solar-like star. This additional wealth of data on small and light stars is a real bonanza for the astronomers. Constraining the Relation Between Mass and Radius Low-mass stars are exceptionally interesting objects, also because the physical conditions in their interiors have much in common with

  17. Performance of First Mammography Examination in Women Younger Than 40 Years

    Science.gov (United States)

    Haneuse, Sebastien; Kapp, Julie M.; Kerlikowske, Karla; Geller, Berta; Buist, Diana S. M.

    2010-01-01

    Background Few data have been published on mammography performance in women who are younger than 40 years. Methods We pooled data from six mammography registries across the United States from the Breast Cancer Surveillance Consortium. We included 117 738 women who were aged 18–39 years when they had their first screening or diagnostic mammogram during 1995–2005 and followed them for 1 year to determine accuracy of mammography assessment. We measured the recall rate for screening examinations and the sensitivity, specificity, positive predictive value, and cancer detection rate for all mammograms. Results For screening mammograms, no cancers were detected in 637 mammograms for women aged 18–24 years. For women aged 35–39 years who had the largest number of screening mammograms (n = 73 335) in this study, the recall rate was 12.7% (95% confidence interval [CI] = 12.4% to 12.9%), sensitivity was 76.1% (95% CI = 69.2% to 82.6%), specificity was 87.5% (95% CI = 87.2% to 87.7%), positive predictive value was 1.3% (95% CI = 1.1% to 1.5%), and cancer detection rate was 1.6 cancers per 1000 mammograms (95% CI = 1.3 to 1.9 cancers per 1000 mammograms). Most (67 468 [77.7%]) of the 86 871 women screened reported no family history of breast cancer. For diagnostic mammograms, the age-adjusted rates across all age groups were: sensitivity of 85.7% (95% CI = 82.7% to 88.7%), specificity of 88.8% (95% CI = 88.4% to 89.1%), positive predictive value of 14.6% (95% CI = 13.3% to 15.8%), and cancer detection rate of 14.3 cancers per 1000 mammograms (95% CI = 13.0 to 15.7 cancers per 1000 mammograms). Mammography performance, except for specificity, improved in the presence of a breast lump. Conclusions Younger women have very low breast cancer rates but after mammography experience high recall rates, high rates of additional imaging, and low cancer detection rates. We found no cancers in women younger than 25 years and poor performance for the large group of women aged

  18. Relative age effect and soccer refereeing: a 'strategic adaptation' of relatively younger children?

    Science.gov (United States)

    Delorme, Nicolas; Radel, Rémi; Raspaud, Michel

    2013-01-01

    Previous research suggested that the relative age effect (RAE) has a psychological influence on children and their decision to engage in a particular sport. Relatively younger children seem to have lower self-esteem. Indeed, because of the disadvantages of being younger, it is assumed that these players experience more situations of failure and inferiority. Because of these negative performance cues, it is likely that these young players feel less competent, which eventually leads to a higher dropout rate. These children can also decide to participate in sports in which physical attributes are less important. This shift from one sport to another can be interpreted as a 'strategic adaptation'. The purpose of this study was thus to investigate whether refereeing could be another form of 'strategic adaptation'. If a child chooses a specific sport but then does not feel competent enough to be a player, refereeing might be an alternate path followed to stay in the environment of a sport they like. Given the minimal age limits for refereeing, two hypotheses were formulated: (1) 'reversed' RAE would be observed in district referees younger than 18 years old and (2) no RAE would be observed in district referees older than 18 years old, regional referees and national referees. The birthdates of all official male soccer referees (n=13,952) were collected from the federation database. Results show that the distribution of all district referees was significantly unbalanced (χ(2)=18.73, df=3, P<0.001) with an over-representation of individuals who were born in the second half of the competitive year. As expected, this imbalance was exclusively located in district referees of 18 years old and less (χ(2)=8.03, df=3, P<0.05), while the distribution was uniform for adults (χ(2)=5.17, df=3, P<0.16). Concerning regional referees (χ(2)=2.09, df=3, P<0.554) and national referees (χ(2)=3.75, df=3, P<0.290), the results also provide support for our initial hypothesis as uniform

  19. Total Knee Arthroplasty in Younger Patients Evaluated by Alternative Outcome Measures

    DEFF Research Database (Denmark)

    Klit, Jakob; Jacobsen, Steffen; Rosenlund, Signe

    2014-01-01

    In this prospective multicenter study we included subjects younger than 60 years of age and scheduled for primary total knee arthroplasty (TKA). The study assessed patients’ overall satisfaction, fulfillment of pre-operative expectations, the effect on socioeconomic parameters, and quality...... of sexual life. Questionnaires including Oxford Knee Score (OKS) and SF-36 were evaluated preoperatively and three, six, and twelve months postoperatively. OKS and SF-36 showed significant improvements. However, patient satisfaction and fulfillment of personal expectations did not reflect these scores....... Overall, TKA did not affect the patients’ socioeconomic status, and overall, patients did not experience impairment of sexual life, but decreased frequency and negative affection of sexual practice should be anticipated. Alternative outcome measurements of TKA surgery not focusing on implants and surgical...

  20. The ironic effect of guessing: increased false memory for mediated lists in younger and older adults.

    Science.gov (United States)

    Coane, Jennifer H; Huff, Mark J; Hutchison, Keith A

    2016-01-01

    Younger and older adults studied lists of words directly (e.g., creek, water) or indirectly (e.g., beaver, faucet) related to a nonpresented critical lure (CL; e.g., river). Indirect (i.e., mediated) lists presented items that were only related to CLs through nonpresented mediators (i.e., directly related items). Following study, participants completed a condition-specific task, math, a recall test with or without a warning about the CL, or tried to guess the CL. On a final recognition test, warnings (vs. math and recall without warning) decreased false recognition for direct lists, and guessing increased mediated false recognition (an ironic effect of guessing) in both age groups. The observed age-invariance of the ironic effect of guessing suggests that processes involved in mediated false memory are preserved in aging and confirms the effect is largely due to activation in semantic networks during encoding and to the strengthening of these networks during the interpolated tasks.

  1. Some geochemical characteristics of alkaline rocks of the Mada Younger Granite complex, Nigeria

    Science.gov (United States)

    Abaa, S. I.

    Some geochemical aspects of the Mada Younger Granite complex are considered. The granites are petrologically classified as A-type, of long time duration, with chemical differences arising from the variation in the A/CNK ratio. The CPW norms show a decrease in anorthite and an increase in corundum in the granites associated with disseminated and vein type cassiterite mineralization. The KRb diagram shows that rocks of the Mada massif crystallized within a pegmatitic-hydrothermal trend. Some chondrite-normalized transition elements indicate that the rocks unaffected by fluid reaction were derived by fractional crystallization. The enhancement of some LIL elements, heavy rare-earths and a decrease in the magnitude of Eu depletion, particularly in the albitized variants of the granites, point to postmagmatic rock-fluid metasomatism and accompanying mineralization.

  2. Diagnosis of the Level of Development of Theoretical Thinking in Intellectually Gifted Younger Students

    Directory of Open Access Journals (Sweden)

    Ermakov S.S.

    2014-08-01

    Full Text Available We describe the development of the theoretical thinking in primary school students and its relationship with intellectual ability in gifted children in elementary school (I-IV classes. We analyze the relation of theoretical thinking development to general intellectual abilities in gifted younger students (students of the Moscow school № 1514 and in general secondary school pupils. Based on this study, we obtained an idea of the extent to which the development of the theoretical level of thinking among primary school students may be an indicator of their general intellectual abilities, both present and potential. The author suggests that the result of solving problems in theoretical thought is directly linked with the level of intelligence in gifted students. Diagnostic techniques of theoretical way of thinking can be used to identify elementary school students with a high level of intellectual development and to predict the further development of their intellectual abilities.

  3. Audio-Visual and Meaningful Semantic Context Enhancements in Older and Younger Adults.

    Science.gov (United States)

    Smayda, Kirsten E; Van Engen, Kristin J; Maddox, W Todd; Chandrasekaran, Bharath

    2016-01-01

    Speech perception is critical to everyday life. Oftentimes noise can degrade a speech signal; however, because of the cues available to the listener, such as visual and semantic cues, noise rarely prevents conversations from continuing. The interaction of visual and semantic cues in aiding speech perception has been studied in young adults, but the extent to which these two cues interact for older adults has not been studied. To investigate the effect of visual and semantic cues on speech perception in older and younger adults, we recruited forty-five young adults (ages 18-35) and thirty-three older adults (ages 60-90) to participate in a speech perception task. Participants were presented with semantically meaningful and anomalous sentences in audio-only and audio-visual conditions. We hypothesized that young adults would outperform older adults across SNRs, modalities, and semantic contexts. In addition, we hypothesized that both young and older adults would receive a greater benefit from a semantically meaningful context in the audio-visual relative to audio-only modality. We predicted that young adults would receive greater visual benefit in semantically meaningful contexts relative to anomalous contexts. However, we predicted that older adults could receive a greater visual benefit in either semantically meaningful or anomalous contexts. Results suggested that in the most supportive context, that is, semantically meaningful sentences presented in the audiovisual modality, older adults performed similarly to young adults. In addition, both groups received the same amount of visual and meaningful benefit. Lastly, across groups, a semantically meaningful context provided more benefit in the audio-visual modality relative to the audio-only modality, and the presence of visual cues provided more benefit in semantically meaningful contexts relative to anomalous contexts. These results suggest that older adults can perceive speech as well as younger adults when both

  4. Perception of Emotion in Conversational Speech by Younger and Older Listeners

    Directory of Open Access Journals (Sweden)

    Juliane eSchmidt

    2016-05-01

    Full Text Available This study investigated whether age and/or differences in hearing sensitivity influence the perception of the emotion dimensions arousal (calm vs. aroused and valence (positive vs. negative attitude in conversational speech. To that end, this study specifically focused on the relationship between participants’ ratings of short affective utterances and the utterances’ acoustic parameters (pitch, intensity, and articulation rate known to be associated with the emotion dimensions arousal and valence. Stimuli consisted of short utterances taken from a corpus of conversational speech. In two rating tasks, younger and older adults either rated arousal or valence using a 5-point scale. Mean intensity was found to be the main cue participants used in the arousal task (i.e., higher mean intensity cueing higher levels of arousal while mean F0 was the main cue in the valence task (i.e., higher mean F0 being interpreted as more negative. Even though there were no overall age group differences in arousal or valence ratings, compared to younger adults, older adults responded less strongly to mean intensity differences cueing arousal and responded more strongly to differences in mean F0 cueing valence. Individual hearing sensitivity among the older adults did not modify the use of mean intensity as an arousal cue. However, individual hearing sensitivity generally affected valence ratings and modified the use of mean F0. We conclude that age differences in the interpretation of mean F0 as a cue for valence are likely due to age-related hearing loss, whereas age differences in rating arousal do not seem to be driven by hearing sensitivity differences between age groups (as measured by pure-tone audiometry.

  5. The impact of augmented information on visuo-motor adaptation in younger and older adults.

    Directory of Open Access Journals (Sweden)

    Mathias Hegele

    Full Text Available BACKGROUND: Adjustment to a visuo-motor rotation is known to be affected by ageing. According to previous studies, the age-related differences primarily pertain to the use of strategic corrections and the generation of explicit knowledge on which strategic corrections are based, whereas the acquisition of an (implicit internal model of the novel visuo-motor transformation is unaffected. The present study aimed to assess the impact of augmented information on the age-related variation of visuo-motor adjustments. METHODOLOGY/PRINCIPAL FINDINGS: Participants performed aiming movements controlling a cursor on a computer screen. Visual feedback of direction of cursor motion was rotated 75 degrees relative to the direction of hand motion. Participants had to adjust to this rotation in the presence and absence of an additional hand-movement target that explicitly depicted the input-output relations of the visuo-motor transformation. An extensive set of tests was employed in order to disentangle the contributions of different processes to visuo-motor adjustment. Results show that the augmented information failed to affect the age-related variations of explicit knowledge, adaptive shifts, and aftereffects in a substantial way, whereas it clearly affected initial direction errors during practice and proprioceptive realignment. CONCLUSIONS: Contrary to expectations, older participants apparently made no use of the augmented information, whereas younger participants used the additional movement target to reduce initial direction errors early during practice. However, after a first block of trials errors increased, indicating a neglect of the augmented information, and only slowly declined thereafter. A hypothetical dual-task account of these findings is discussed. The use of the augmented information also led to a selective impairment of proprioceptive realignment in the younger group. The mere finding of proprioceptive realignment in adaptation to a visuo

  6. Younger age as a prognostic indicator in breast cancer: A cohort study

    LENUS (Irish Health Repository)

    Kheirelseid, Elrasheid A.H.

    2011-08-28

    Abstract Background The debate continues as to whether younger women who present with breast cancer have a more aggressive form of disease and a worse prognosis. The objectives of this study were to determine the incidence of breast cancer in women under 40 years old and to analyse the clinicopathological characteristics and outcome compared to an older patient cohort. Methods Data was acquired from a review of charts and the prospectively reviewed GUH Department of Surgery database. Included in the study were 276 women diagnosed with breast cancer under the age of forty and 2869 women over forty. For survival analysis each women less than 40 was matched with two women over forty for both disease stage and grade. Results The proportion of women diagnosed with breast cancer under the age of forty in our cohort was 8.8%. In comparison to their older counterparts, those under forty had a higher tumour grade (p = 0.044) and stage (p = 0.046), a lower incidence of lobular tumours (p < 0.001), higher estrogen receptor negativity (p < 0.001) and higher HER2 over-expression (p = 0.002); there was no statistical difference as regards tumour size (p = 0.477). There was no significant difference in overall survival (OS) for both groups; and factors like tumour size (p = 0.026), invasion (p = 0.026) and histological type (p = 0.027), PR (p = 0.031) and HER2 (p = 0.002) status and treatment received were independent predictors of OS Conclusion Breast cancer in younger women has distinct histopathological characteristics; however, this does not result in a reduced survival in this population.

  7. On certain aspects of the semantic development of younger primary school-age children

    Directory of Open Access Journals (Sweden)

    Stevanović Jelena

    2014-01-01

    Full Text Available The ability to understand the meaning of words and sentences is an important determinant of the language development, which also indicates the development of the ability to learn. Bearing this in mind, the research was aimed at studying the level of semantic development of younger primary school-age children. Semantic development was studied from the aspect of understanding the meaning of words and their use in the following lexical relations: homonyms, antonyms, synonyms and metonyms. The research was conducted in three Belgrade primary schools during the school year 2013/2014. The sample was convenient and included 431 second- and third-grade pupils. The Semantic test (by S. Vladisavljevic was used in the study. Research results showed that none of the pupils had provided the correct answer to all administered tasks. The best scores were achieved on the part of the test referring to antonyms, while the pupils were least successful on the tasks referring to metonyms. Additionally, third-grade pupils were more successful than younger participants, while there were no differences according to gender. The results indicated that it was necessary to devote more attention to different lexical and semantic exercises at preschool and early school age, considering the link between semantic development, the acquisition of reading and writing skills and the (unsuccessful mastering of the school curriculum in the majority of subjects. [Projekat Ministarstva nauke Republike Srbije, br. 179034: Od podsticanja inicijative, saradnje, stvaralaštva u obrazovanju do novih uloga i identiteta u društvu i br. 47008: Unapređivanje kvaliteta i dostupnosti obrazovanja u procesima modernizacije Srbije

  8. Pial synangiosis in patients with moyamoya younger than 2 years of age.

    Science.gov (United States)

    Jackson, Eric M; Lin, Ning; Manjila, Sunil; Scott, R Michael; Smith, Edward R

    2014-04-01

    Object Patients with moyamoya who are younger than 2 years of age represent a therapeutic challenge because of their frequent neurological instability and concomitant anesthetic risks. The authors report their experience with pial synangiosis revascularization in this population. Methods The authors reviewed the clinical and radiographic records of all patients with moyamoya in a consecutive series of patients under 2 years of age, who underwent cerebral revascularization surgery using pial synangiosis at a single institution. Results During a 12-year period (1994-2005), 34 procedures (bilateral in 15 patients, unilateral in 4) were performed in 19 patients younger than 2 years (out of a total of 456 procedures in 240 patients). Eighteen of these patients presented with either stroke or transient ischemic attack. The average age of the 19 patients at first surgery was 1.4 years (range 6 months-1.9 years). Unanticipated staged operations occurred in 3 patients, due to persistent electroencephalographic changes during the initial surgery in 2 cases and due to brain swelling during the procedure requiring ventriculostomy in the other. There were 2 perioperative strokes; both patients had postoperative seizures but made clinical recoveries. The average follow-up was 7 years (range 1-14 years). Long term, at follow-up, 13 patients (68%) were clinically independent for their age, with 8 (42%) having no significant deficit. Late complications included subdural hygroma evacuation (1), additional revascularization procedures performed years later for frontal lobe ischemia (2), late infarction (1), and asymptomatic ischemic change on routine follow-up MRI studies (1). All patients who had both pre- and postoperative angiography demonstrated progression of disease. Conclusions Despite the challenges inherent to this population, the majority of children with moyamoya under the age of 2 years have a good long-term prognosis. The data from this study support the use of pial

  9. Global strategy for the diagnosis and management of asthma in children 5 years and younger.

    Science.gov (United States)

    Pedersen, Soren Erik; Hurd, Suzanne S; Lemanske, Robert F; Becker, Allan; Zar, Heather J; Sly, Peter D; Soto-Quiroz, Manuel; Wong, Gary; Bateman, Eric D

    2011-01-01

    Asthma is the most common chronic disease of childhood and the leading cause of childhood morbidity from chronic disease as measured by school absences, emergency department visits, and hospitalisation. During the past two decades, many scientific advances have improved our understanding of asthma and our ability to manage and control it effectively. However, in children 5 years and younger, the clinical symptoms of asthma are variable and non-specific. Furthermore, neither airflow limitation nor airway inflammation, the main pathologic hallmarks of the condition, can be assessed routinely in this age group. For this reason, to aid in the diagnosis of asthma in young children, a symptoms-only descriptive approach that includes the definition of various wheezing phenotypes has been recommended. In 1993, the Global Initiative for Asthma (GINA) was implemented to develop a network of individuals, organizations, and public health officials to disseminate information about the care of patients with asthma while at the same time assuring a mechanism to incorporate the results of scientific investigations into asthma care. Since then, GINA has developed and regularly revised a Global Strategy for Asthma Management and Prevention. Publications based on the Global Strategy for Asthma Management and Prevention have been translated into many different languages to promote international collaboration and dissemination of information. In this report, Global Strategy for Asthma Management and Prevention in Children 5 Years and Younger, an effort has been made to present the special challenges that must be taken into account in managing asthma in children during the first 5 years of life, including difficulties with diagnosis, the efficacy and safety of drugs and drug delivery systems, and the lack of data on new therapies. Approaches to these issues will vary among populations in the world based on socioeconomic conditions, genetic diversity, cultural beliefs, and differences in

  10. Clinical results of the Metha short hip stem: a perspective for younger patients?

    Directory of Open Access Journals (Sweden)

    Fritz Thorey

    2013-11-01

    Full Text Available In recent years, various uncemented proximal metaphyseal hip stems were introduced for younger patients as a bone preserving strategy. Initial osteodensitometric analyses of the surrounding bone of short stems indicate an increase of bone mass with secondary bone ingrowth fixation as a predictor of long-term survival of these types of implants. We report the outcome of 151 modular Metha short hip stem implants in 148 patients between March 2005 and October 2007. The mean follow-up was 5.8±0.7 years and the mean age of the patients was 55.7±9.8 years. Along with demographic data and co-morbidities, the Harris Hip Score (HHS, the Hip dysfunction and Osteoarthritis Outcome Score (HOOS, and also the results of a patient-administered questionnaire were recorded pre-operatively and at follow-up. The mean HHS increased from 46±17 pre-operatively to 90±5 the HOOS improved from 55±16 pre-operatively to 89±10 at the final follow-up. A total of three patients have been revised, two for subsidence with femoral revision and one for infection without femoral revision (Kaplan Meier survival estimate 98%. The radiological findings showed no radiolucent lines in any of the patients. The modular Metha short hip stem was implanted in younger patients, who reported an overall high level of satisfaction. The clinical and radiographic results give support to the principle of using short stems with metaphyseal anchorage. However, long-term results are necessary to confirm the success of this concept in the years to come.

  11. Phishing suspiciousness in older and younger adults: The role of executive functioning

    Science.gov (United States)

    Zhao, Rui; John, Samantha E.; Bussell, Cara A.; Roberts, Jennifer R.; Yue, Chuan

    2017-01-01

    Phishing is the spoofing of Internet websites or emails aimed at tricking users into entering sensitive information, with such goals as financial or identity theft. The current study sought to determine whether age is associated with increased susceptibility to phishing and whether tests of executive functioning can predict phishing susceptibility. A total of 193 cognitively intact participants, 91 younger adults and 102 older adults, were primarily recruited through a Psychology department undergraduate subject pool and a gerontology research registry, respectively. The Executive Functions Module from the Neuropsychological Assessment Battery and the Iowa Gambling Task were the primary cognitive predictors of reported phishing suspiciousness. Other predictors included age group (older vs. younger), sex, education, race, ethnicity, prior knowledge of phishing, prior susceptibility to phishing, and whether or not browsing behaviors were reportedly different in the laboratory setting versus at home. A logistic regression, which accounted for a 22.7% reduction in error variance compared to the null model and predicted phishing suspiciousness with 73.1% (95% CI [66.0, 80.3]) accuracy, revealed three statistically significant predictors: the main effect of education (b = 0.58, SE = 0.27) and the interactions of age group with prior awareness of phishing (b = 2.31, SE = 1.12) and performance on the Neuropsychological Assessment Battery Mazes test (b = 0.16, SE = 0.07). Whether or not older adults reported being suspicious of the phishing attacks used in this study was partially explained by educational history and prior phishing knowledge. This suggests that simple educational interventions may be effective in reducing phishing vulnerability. Although one test of executive functioning was found useful for identifying those at risk of phishing susceptibility, four tests were not found to be useful; these results speak to the need for more ecologically valid tools in

  12. Cattle Candidate Genes for Milk Production Traits

    OpenAIRE

    Kadlec, Tomáš

    2012-01-01

    The aim of this thesis is to make an overview of important candidate genes affecting milk yield and milk quality parameters, with an emphasis on genes associated with the quantity and quality of milk proteins and milk fat.

  13. New Zika Vaccine Candidate Provides Powerful Protection

    Science.gov (United States)

    ... https://medlineplus.gov/news/fullstory_163384.html New Zika Vaccine Candidate Provides Powerful Protection Made without live ... HealthDay News) -- A single dose of an experimental Zika vaccine protected mice and monkeys from the virus, ...

  14. Bioinformatics methods for identifying candidate disease genes

    NARCIS (Netherlands)

    Driel, M.A. van; Brunner, H.G.

    2006-01-01

    With the explosion in genomic and functional genomics information, methods for disease gene identification are rapidly evolving. Databases are now essential to the process of selecting candidate disease genes. Combining positional information with disease characteristics and functional information i

  15. Towards Treating Chemistry Teacher Candidates as Human

    Science.gov (United States)

    Lewthwaite, Brian Ellis

    2008-05-01

    This research inquiry investigates the factors influencing chemistry teacher candidates’ development during their extended practica in the second and final year of an After-Degree Bachelor of Education at a university in central Canada. A variety of data sources are used to identify the risk and protective factors impeding and contributing to the achievement of their chemistry pedagogical aspirations. Two theoretical frameworks, both having their origins in the pioneering work of Kurt Lewin, are used to conceptualize how a complex amalgam of personal attribute and environmental factors and the interplay among these factors influence teacher candidate developmental trajectories. The tenets of both Bronfenbrenner’s bioecological model and Learning Environment research provide insights into how the factors influencing teacher candidate development can be understood and systematically documented to provide a template for reflective consideration of the practicum experience for both teacher candidates and those involved in fostering the development of chemistry teacher candidates.

  16. Bioinformatics methods for identifying candidate disease genes

    Directory of Open Access Journals (Sweden)

    van Driel Marc A

    2006-06-01

    Full Text Available Abstract With the explosion in genomic and functional genomics information, methods for disease gene identification are rapidly evolving. Databases are now essential to the process of selecting candidate disease genes. Combining positional information with disease characteristics and functional information is the usual strategy by which candidate disease genes are selected. Enrichment for candidate disease genes, however, depends on the skills of the operating researcher. Over the past few years, a number of bioinformatics methods that enrich for the most likely candidate disease genes have been developed. Such in silico prioritisation methods may further improve by completion of datasets, by development of standardised ontologies across databases and species and, ultimately, by the integration of different strategies.

  17. Doctors applying for Danish postgraduate medical specialist training are getting younger

    DEFF Research Database (Denmark)

    Kjaer, N. K.; Clausen, L. W.; Qvesel, D.

    2012-01-01

    was to highlight the present characteristics of young doctors who entered specialist training. MATERIAL AND METHODS: Data include 443 doctors who were enrolled in a formalized postgraduate medical training programme in the Region of Southern Denmark from 2009 to 2011. RESULTS: 41% of the recruited young doctors...... were men and 59% were women. The average age for doctors recruited for residency training was 35 years and the average time from graduation to initiation of specialist training (candidate age) was 70 months. If foreign graduates were excluded, the average age was 34 years and average candidate age...... was 58 months. 6% of the recruited doctors had a PhD. 61% of the doctors were graduates from the University of Southern Denmark. 14% graduated from the University of Copenhagen and 12% from Aarhus University. Finally, 13% graduated from a foreign university. CONCLUSION: Applicants accepted for specialist...

  18. Do People 'Like' Candidates on Facebook?

    DEFF Research Database (Denmark)

    Nielsen, Rasmus Kleis

    The online popularity of a few exceptional candidates has led many to suggest that social media have given politicians powerful ways of communicating directly with voters. In this paper, we examine whether this is happening on a significant scale and show, based on analysis of 224 candidates....... We therefore suggest that the political implications of social media are generally better understood in terms of facilitating indirect communication and institutional change than in terms of direct communication....

  19. Cardiac evaluation of liver transplant candidates

    Institute of Scientific and Technical Information of China (English)

    Mercedes Susan Mandell; JoAnn Lindenfeld; Mei-Yung Tsou; Michael Zimmerman

    2008-01-01

    Physicians previously thought that heart disease was rare in patients with end stage liver disease. However, recent evidence shows that the prevalence of ischemic heart disease and cardiomyopathy is increased in transplant candidates compared to most other surgical candidates. Investigators estimate that up to 26% of all liver transplant candidates have at least one critical coronary artery stenosis and that at least half of these patients will die perioperatively of cardiac complications. Cardiomyopathy also occurs in greater frequency. While all patients with advanced cardiac disease have defects in cardiac performance, a larger than expected number of patients have classical findings of dilated, restrictive and hypertropic cardiomyopathy. This may explain why up to 56% of patients suffer from hypoxemia due to pulmonary edema following transplant surgery. There is considerable controversy on how to screen transplant candidates for the presence of heart disease. Questions focus upon, which patients should be screened and what tests should be used. This review examines screening strategies for transplant candidates and details the prognostic value of common tests used to identify ischemic heart disease. We also review the physiological consequences of cardiomyopathy in transplant candidates and explore the specific syndrome of "cirrhotic cardiomyopathy".

  20. A New Way to Confirm Planet Candidates

    Science.gov (United States)

    Kohler, Susanna

    2016-05-01

    What was the big deal behind the Kepler news conference yesterday? Its not just that the number of confirmed planets found by Kepler has more than doubled (though thats certainly exciting news!). Whats especially interesting is the way in which these new planets were confirmed.Number of planet discoveries by year since 1995, including previous non-Kepler discoveries (blue), previous Kepler discoveries (light blue) and the newly validated Kepler planets (orange). [NASA Ames/W. Stenzel; Princeton University/T. Morton]No Need for Follow-UpBefore Kepler, the way we confirmed planet candidates was with follow-up observations. The candidate could be validated either by directly imaging (which is rare) or obtaining a large number radial-velocity measurements of the wobble of the planets host star due to the planets orbit. But once Kepler started producing planet candidates, these approaches to validation became less feasible. A lot of Kepler candidates are small and orbit faint stars, making follow-up observations difficult or impossible.This problem is what inspired the development of whats known as probabilistic validation, an analysis technique that involves assessing the likelihood that the candidates signal is caused by various false-positive scenarios. Using this technique allows astronomers to estimate the likelihood of a candidate signal being a true planet detection; if that likelihood is high enough, the planet candidate can be confirmed without the need for follow-up observations.A breakdown of the catalog of Kepler Objects of Interest. Just over half had previously been identified as false positives or confirmed as candidates. 1284 are newly validated, and another 455 have FPP of1090%. [Morton et al. 2016]Probabilistic validation has been used in the past to confirm individual planet candidates in Kepler data, but now Timothy Morton (Princeton University) and collaborators have taken this to a new level: they developed the first code thats designed to do fully

  1. Alternate Immersion in an External Glucose Solution Differentially Affects Blood Sugar Values in Older Versus Younger Zebrafish Adults.

    Science.gov (United States)

    Connaughton, Victoria P; Baker, Cassandra; Fonde, Lauren; Gerardi, Emily; Slack, Carly

    2016-04-01

    Recently, zebrafish have been used to examine hyperglycemia-induced complications (retinopathy and neuropathy), as would occur in individuals with diabetes. Current models to induce hyperglycemia in zebrafish include glucose immersion and streptozotocin injections. Both are effective, although neither is reported to elevate blood sugar values for more than 1 month. In this article, we report differences in hyperglycemia induction and maintenance in young (4-11 months) versus old (1-3 years) zebrafish adults. In particular, older fish immersed in an alternating constant external glucose solution (2%) for 2 months displayed elevated blood glucose levels for the entire experimental duration. In contrast, younger adults displayed only transient hyperglycemia, suggesting the fish were acclimating to the glucose exposure protocol. However, modifying the immersion protocol to include a stepwise increasing glucose concentration (from 1% → 2%→3%) resulted in maintained hyperglycemia in younger zebrafish adults for up to 2 months. Glucose-exposed younger fish collected after 8 weeks of exposure also displayed a significant decrease in wet weight. Taken together, these data suggest different susceptibilities to hyperglycemia in older and younger fish and that stepwise increasing glucose concentrations of 1% are required for maintenance of hyperglycemia in younger adults, with higher concentrations of glucose resulting in greater increases in blood sugar values.

  2. Older adults catch up to younger adults on a learning and memory task that involves collaborative social interaction.

    Science.gov (United States)

    Derksen, B J; Duff, M C; Weldon, K; Zhang, J; Zamba, K D; Tranel, D; Denburg, N L

    2015-01-01

    Learning and memory abilities tend to decline as people age. The current study examines the question of whether a learning situation that emphasises collaborative social interaction might help older persons overcome age-related learning and memory changes and thus perform similarly to younger persons. Younger and Older participants (n = 34 in each group) completed the Barrier Task (BT), a game-like social interaction where partners work together to develop labels for a set of abstract tangrams. Participants were also administered standard clinical neuropsychological measures of memory, on which the Older group showed expected inferiority to the Younger group. On the BT, the Older group performed less well than the Younger group early on, but as the task progressed, the performance of the Older group caught up and became statistically indistinguishable from that of the Younger group. These results can be taken to suggest that a learning milieu characterised by collaborative social interaction can attenuate some of the typical memory disadvantages associated with being older.

  3. JELLYFISH GALAXY CANDIDATES AT LOW REDSHIFT

    Energy Technology Data Exchange (ETDEWEB)

    Poggianti, B. M.; Fasano, G.; Omizzolo, A.; Gullieuszik, M.; Bettoni, D.; Paccagnella, A. [INAF-Astronomical Observatory of Padova (Italy); Moretti, A.; D’Onofrio, M. [Physics and Astronomy Department, University of Padova (Italy); Jaffé, Y. L. [Department of Astronomy, Universidad de Concepción, Concepción (Chile); Vulcani, B. [Kavli Institute for the Physics and Mathematics of the universe (WPI), The University of Tokyo Institutes for Advanced Study (UTIAS), the University of Tokyo, Kashiwa, 277-8582 (Japan); Fritz, J. [Centro de Radioastronomía y Astrofísica, CRyA, UNAM, Michoacán (Mexico); Couch, W. [Australian Astronomical Observatory, North Ryde, NSW 1670 (Australia)

    2016-03-15

    Galaxies that are being stripped of their gas can sometimes be recognized from their optical appearance. Extreme examples of stripped galaxies are the so-called “jellyfish galaxies” that exhibit tentacles of debris material with a characteristic jellyfish morphology. We have conducted the first systematic search for galaxies that are being stripped of their gas at low-z (z = 0.04−0.07) in different environments, selecting galaxies with varying degrees of morphological evidence for stripping. We have visually inspected B- and V-band images and identified 344 candidates in 71 galaxy clusters of the OMEGAWINGS+WINGS sample and 75 candidates in groups and lower mass structures in the PM2GC sample. We present the atlas of stripping candidates and a first analysis of their environment and their basic properties, such as morphologies, star formation rates and galaxy stellar masses. Candidates are found in all clusters and at all clustercentric radii, and their number does not correlate with the cluster velocity dispersion σ or X-ray luminosity L{sub X}. Interestingly, convincing cases of candidates are also found in groups and lower mass halos (10{sup 11}−10{sup 14}M{sub ⊙}), although the physical mechanism at work needs to be securely identified. All the candidates are disky, have stellar masses ranging from log M/M{sub ⊙} < 9 to > 11.5 and the majority of them form stars at a rate that is on average a factor of 2 higher (2.5σ) compared to non-stripped galaxies of similar mass. The few post-starburst and passive candidates have weak stripping evidence. We conclude that disturbed morphologies suggestive of stripping phenomena are ubiquitous in clusters and could be present even in groups and low mass halos. Further studies will reveal the physics of the gas stripping and clarify the mechanisms at work.

  4. Jellyfish Galaxy Candidates at Low Redshift

    Science.gov (United States)

    Poggianti, B. M.; Fasano, G.; Omizzolo, A.; Gullieuszik, M.; Bettoni, D.; Moretti, A.; Paccagnella, A.; Jaffé, Y. L.; Vulcani, B.; Fritz, J.; Couch, W.; D'Onofrio, M.

    2016-03-01

    Galaxies that are being stripped of their gas can sometimes be recognized from their optical appearance. Extreme examples of stripped galaxies are the so-called “jellyfish galaxies” that exhibit tentacles of debris material with a characteristic jellyfish morphology. We have conducted the first systematic search for galaxies that are being stripped of their gas at low-z (z = 0.04-0.07) in different environments, selecting galaxies with varying degrees of morphological evidence for stripping. We have visually inspected B- and V-band images and identified 344 candidates in 71 galaxy clusters of the OMEGAWINGS+WINGS sample and 75 candidates in groups and lower mass structures in the PM2GC sample. We present the atlas of stripping candidates and a first analysis of their environment and their basic properties, such as morphologies, star formation rates and galaxy stellar masses. Candidates are found in all clusters and at all clustercentric radii, and their number does not correlate with the cluster velocity dispersion σ or X-ray luminosity LX. Interestingly, convincing cases of candidates are also found in groups and lower mass halos (1011-1014M⊙), although the physical mechanism at work needs to be securely identified. All the candidates are disky, have stellar masses ranging from log M/M⊙ 11.5 and the majority of them form stars at a rate that is on average a factor of 2 higher (2.5σ) compared to non-stripped galaxies of similar mass. The few post-starburst and passive candidates have weak stripping evidence. We conclude that disturbed morphologies suggestive of stripping phenomena are ubiquitous in clusters and could be present even in groups and low mass halos. Further studies will reveal the physics of the gas stripping and clarify the mechanisms at work.

  5. Deep Washington photometry of inconspicuous star cluster candidates in the Large Magellanic Cloud

    Energy Technology Data Exchange (ETDEWEB)

    Choudhury, Samyaday; Subramaniam, Annapurni [Indian Institute of Astrophysics, 2B Koramangala, Bangalore 560034 (India); Piatti, Andrés E., E-mail: samyaday@iiap.res.in [Observatorio Astronómico, Universidad Nacional de Córdoba, Laprida 854, X5000BGR, Córdoba (Argentina)

    2015-02-01

    We present deep Washington photometry of 45 poorly populated star cluster candidates in the Large Magellanic Cloud (LMC). We have performed a systematic study to estimate the parameters of the cluster candidates by matching theoretical isochrones to the cleaned and dereddened cluster color–magnitude diagrams. We were able to estimate the basic parameters for 33 clusters, out of which 23 are identified as single clusters and 10 are found to be members of double clusters. The other 12 cluster candidates have been classified as possible clusters/asterisms. About 50% of the true clusters are in the 100–300 Myr age range, whereas some are older or younger. We have discussed the distribution of age, location, and reddening with respect to field, as well as the size of true clusters. The sizes and masses of the studied sample are found to be similar to that of open clusters in the Milky Way. Our study adds to the lower end of cluster mass distribution in the LMC, suggesting that the LMC, apart from hosting rich clusters, also has formed small, less massive open clusters in the 100–300 Myr age range.

  6. Coping with chronic pain among younger, middle-aged, and older adults living with neurological injury and disease.

    Science.gov (United States)

    Molton, Ivan; Jensen, Mark P; Ehde, Dawn M; Carter, Gregory T; Kraft, George; Cardemas, Diana D

    2008-01-01

    Objective. This article compares use of pain coping strategies among older, middle-aged, and younger adults living with chronic pain and seeks to determine whether the relationship between pain severity and coping is moderated by age. Method. Participants were 464 adults reporting chronic pain secondary to multiple sclerosis, spinal cord injury, or neuromuscular disease. Participants completed a survey including measures of pain severity and the Chronic Pain Coping Inventory. Results. After controlling for clinical and demographic variables, older adults (older than 60) reported a wider range of frequently used strategies and significantly more frequent engagement in activity pacing, seeking social support, and use of coping self-statements than did younger or middle-aged adults. Moderation analyses suggest that, for younger adults, efforts at coping generally increased with greater pain severity, whereas this relationship did not exist for older adults. Discussion. These data suggest differences in the quantity and quality of pain coping among age groups.

  7. Evaluating historical candidate genes for schizophrenia.

    Science.gov (United States)

    Farrell, M S; Werge, T; Sklar, P; Owen, M J; Ophoff, R A; O'Donovan, M C; Corvin, A; Cichon, S; Sullivan, P F

    2015-05-01

    Prior to the genome-wide association era, candidate gene studies were a major approach in schizophrenia genetics. In this invited review, we consider the current status of 25 historical candidate genes for schizophrenia (for example, COMT, DISC1, DTNBP1 and NRG1). The initial study for 24 of these genes explicitly evaluated common variant hypotheses about schizophrenia. Our evaluation included a meta-analysis of the candidate gene literature, incorporation of the results of the largest genomic study yet published for schizophrenia, ratings from informed researchers who have published on these genes, and ratings from 24 schizophrenia geneticists. On the basis of current empirical evidence and mostly consensual assessments of informed opinion, it appears that the historical candidate gene literature did not yield clear insights into the genetic basis of schizophrenia. A likely reason why historical candidate gene studies did not achieve their primary aims is inadequate statistical power. However, the considerable efforts embodied in these early studies unquestionably set the stage for current successes in genomic approaches to schizophrenia.

  8. Familiar Real-World Spatial Cues Provide Memory Benefits in Older and Younger Adults.

    Science.gov (United States)

    Robin, Jessica; Moscovitch, Morris

    2017-02-23

    Episodic memory, future thinking, and memory for scenes have all been proposed to rely on the hippocampus, and evidence suggests that these all decline in healthy aging. Despite this age-related memory decline, studies examining the effects of context reinstatement on episodic memory have demonstrated that reinstating elements of the encoding context of an event leads to better memory retrieval in both younger and older adults. The current study was designed to test whether more familiar, real-world contexts, such as locations that participants visited often, would improve the detail richness and vividness of memory for scenes, autobiographical events, and imagination of future events in young and older adults. The predicted age-related decline in internal details across all 3 conditions was accompanied by persistent effects of contextual familiarity, in which a more familiar spatial context led to increased detail and vividness of remembered scenes, autobiographical events, and, to some extent, imagined future events. This study demonstrates that autobiographical memory, imagination of the future, and scene memory are similarly affected by aging, and all benefit from being associated with more familiar (real-world) contexts, illustrating the stability of contextual reinstatement effects on memory throughout the life span. (PsycINFO Database Record

  9. Associative memory advantage in grapheme-colour synaesthetes compared to older, but not younger adults

    Directory of Open Access Journals (Sweden)

    Gaby ePfeifer

    2014-07-01

    Full Text Available People with grapheme-colour synaesthesia perceive enriched experiences of colours in response to graphemes (letters, digits. In this study, we examined whether these synaesthetes show a generic associative memory advantage for stimuli that do not elicit a synaesthetic colour. We used a novel between group design (14 young synaesthetes, 14 young and 14 older adults with a self-paced visual associative learning paradigm and subsequent retrieval (immediate and delayed. Non-synaesthesia inducing, achromatic fractal pair-associates were manipulated in visual similarity (high and low and corresponded to high and low memory load conditions. The main finding was a learning and retrieval advantage of synaesthetes relative to older, but not to younger, adults. Furthermore the significance testing was supported with effect size measures and power calculations. Differences between synaesthetes and older adults were found during dissimilar pair (high memory load learning and retrieval at immediate and delayed stages. Moreover, we found a medium size difference between synaesthetes and young adults for similar pair (low memory load learning. Differences between young and older adults were also observed during associative learning and retrieval, but were of medium effect size coupled with low power. The results show a subtle associative memory advantage in synaesthetes for non-synaesthesia inducing stimuli, which can be detected against older adults. They also indicate that perceptual mechanisms (enhanced in synaesthesia, declining as part of the aging process can translate into a generic associative memory advantage, and may contribute to associative deficits associated with healthy aging.

  10. What a Veteran Engineer Who Passed Postwar Period Expects of Younger Generation Engineers

    Science.gov (United States)

    Hata, Ryosuke

    Almost all engineers who were born during the postwar several years should have done their best merely to support themselves and Japanese people and to reconstruct Japan just as a servant of the public. After having reached the summit of economy followed by achieving “Japan as No. 1” based upon their such reckless hard-working results, they unexpectedly encountered the collapse of the bubble economy, even worse, with a variety of engineering-orientated industries-based environmental issues. As one of such engineers, upon deep reflection, the author would like to advise that the younger generation engineers in this 21st century should do their best efforts to evolve society for better future on the basis of their own future-oriented decision. To do this, engineers should be more flexible in thinking and learn widely out of their specialty. Based upon experience, the author also wants to offer them some ideas like on what basis a decision is made, how symbolic characters on engineering substitutes should be, what is engineering fact, how to verify the engineering fact, the importance of “and” instead of “or” or the concept of “4 : 4 : 2” for them to fulfill their engineer's missions in a better way.

  11. Peak expiratory flow rate; the effect of smoking on younger AND middle aged males

    Directory of Open Access Journals (Sweden)

    B. Satyanarayana

    2013-08-01

    Full Text Available A total of 80 male subjects in age group of 20-50 years were selected for the purpose of the study. They were divided in two groups, smokers and non smokers. Each group subdivided into age groups of 20-35 and 36-50 yrs. The criteria for smoking was about 5-10 cigarettes per day since 6-12 months. Peak Expiratory Flow Rate (P.E.F.R. was determined by using Wright’s peak flow meter. The results showed that in Non-Smoker of age group 20-35 years, (n= 30 the mean PEFR value was 535±50 L/min, whereas in age group 36-50 years, (n=15 the mean P.E.F.R value was 515±50 L/min. In Smokers of age group 20-35 years, (n=10 mean P.E.F.R. value was 374±128 L/min whereas in age group 36-50 years, (n=25 mean P.E.F.R. value was 357±86 L/min. This shows that in smokers P.E.F.R. value is lower compared to Non-smokers in both age groups and that P.E.F.R. is lower in the elder age group in comparison to younger age group. [Int J Res Med Sci 2013; 1(4.000: 441-442

  12. Younger smokers continue to smoke as adults: implications for raising the smoking age to 21

    Directory of Open Access Journals (Sweden)

    Robbins RA

    2017-01-01

    Full Text Available No abstract available. Article truncated after 150 words. A review article published in Pediatrics assesses the evidence that smoking is particularly harmful the younger a smoker begins (1. Not only do youths tend to accumulate more pack-years but they have more difficulty quitting. The recent shift in smoking trends from tobacco cigarettes to e-cigarettes may not be helpful since both contain the addictive component, nicotine. Although e-cigarettes are marketed as a smoking cessation tool, there is no strong evidence to support these claims, the authors report."I think most people realize nicotine is addictive, but I don't know if there's an understanding of just how addictive it is – particularly for youths," said Lorena M. Siqueira, MD, MSPH, lead author of the report (2. Evidence shows that the earlier in life a person is exposed to nicotine, the more likely they will consume greater quantities and the less likely they will be able to quit (1,2. The vast majority …

  13. Progress in paediatric parasitology: a preface to a topic focusing on ever younger subjects.

    Science.gov (United States)

    Stothard, J Russell; Chiodini, Peter; Booth, Mark

    2011-10-01

    Without realizing it perhaps, the research activities of many parasitologists are often focused upon the study of parasites most commonly found in children. Though there is little recognition of paediatric parasitology as a separate topic within medical parasitology, with the global interest in promotion of maternal and child health, alleviation of diseases associated with poverty and requirements of 'child-sized' medicines, a more formal consideration is now timely. Recent research, for example, has highlighted that defining precisely the 'first-age' at which parasites interfere with a child's health, or normal developmental processes, is being revised. Attention is now drawn towards ever younger subjects, for parasites have the capacity to also influence the health of the foetus within the in utero environment, altering immune-development. These subtle, yet evolutionary profound interactions perhaps manifest themselves as to why some children are more prone to infection(s), develop overt disease and sadly die while others do not. Here, we address the growing importance of paediatric parasitology and its applications within disease control strategies as highlighted in the 2010 Autumn Symposium of the British Society of Parasitology.

  14. Consensus Recommendations for Advancing Breast Cancer: Risk Identification and Screening in Ethnically Diverse Younger Women

    Directory of Open Access Journals (Sweden)

    Alexander Stojadinovic, Thomas A Summers, John Eberhardt, Albert Cerussi, Warren Grundfest, Charles M. Peterson, Michael Brazaitis, Elizabeth Krupinski, Harold Freeman

    2011-01-01

    Full Text Available A need exists for a breast cancer risk identification paradigm that utilizes relevant demographic, clinical, and other readily obtainable patient-specific data in order to provide individualized cancer risk assessment, direct screening efforts, and detect breast cancer at an early disease stage in historically underserved populations, such as younger women (under age 40 and minority populations, who represent a disproportionate number of military beneficiaries. Recognizing this unique need for military beneficiaries, a consensus panel was convened by the USA TATRC to review available evidence for individualized breast cancer risk assessment and screening in young (< 40, ethnically diverse women with an overall goal of improving care for military beneficiaries. In the process of review and discussion, it was determined to publish our findings as the panel believes that our recommendations have the potential to reduce health disparities in risk assessment, health promotion, disease prevention, and early cancer detection within and in other underserved populations outside of the military. This paper aims to provide clinicians with an overview of the clinical factors, evidence and recommendations that are being used to advance risk assessment and screening for breast cancer in the military.

  15. The structure and petrography of alkaline rocks of the Mada Younger Granite complex, Nigeria

    Science.gov (United States)

    Abaa, S. I.

    The structural aspects of the Mada Younger Granite complex differ from those described from other ring complexes in the province. Ring-dykes and cauldron subsidence structures are not observed and the extrusive rhyolites do not appear to be related to a volcanic cauldron. The minor remnants of the extrusive rocks were domes over small vents since there are no clear indications of any unified volcanic structure. Volcanic eruptions may have taken place from dispersed vents probably including pipes and fissures. Linear intrusive structures have been observed and there is no concentric arrangement of rock units. The biotite granites appear more as sheet structures dipping gently to the south. Petrographically, the extrusive rocks are rhyolites, the comenditic ignimbrite being distinctly peralkaline with aegirine and arfvedsonite. The granite cupolas may be classified as 'A'-type and have been affected by pervasive potash metasomatism which caused recrystallization with microline and finely twinned clear euhedral albite, together with mica compositions between annite towards lithian siderophyllite. This process also introduced minerals like fluorite, cassiterite, columbite and thorite which make the Mada complex a possible source for economic minerals.

  16. Increased Incidence of Interatrial Block in Younger Adults with Cryptogenic Stroke and Patent Foramen Ovale

    Directory of Open Access Journals (Sweden)

    P.E. Cotter

    2011-04-01

    Full Text Available Background: Stroke is often unexplained in younger adults, although it is often associated with a patent foramen ovale (PFO. The reason for the association is not fully explained, and mechanisms other than paradoxical embolism may be involved. Young stroke patients with PFO have more atrial vulnerability than those without PFO. It is plausible that stretching of the interatrial septum may disrupt the interatrial conduction pathways causing interatrial block (IAB. IAB is associated with atrial fibrillation, dysfunctional left atria and stroke. Methods: Electrocardiogram (ECG characteristics of prospectively recruited young patients (≤55 years of age with unexplained stroke (TOAST and A-S-C-O were compared with control data. All stroke cases underwent bubble contrast transthoracic and transoesophageal echography. IAB was defined as a P-wave duration of ≧110 ms. ECG data were converted to electronic format and analysed in a blind manner. Results: Fifty-five patients and 23 datasets were analysed. Patients with unexplained stroke had longer P-wave duration (p = 0.013 and a greater prevalence of IAB (p = 0.02 than healthy controls. Case status was an independent predictor of P-wave duration in a significant multivariate model. There was a significant increase in the proportion of cases with a PFO with IAB compared with cases without PFO and with controls (p = 0.005. Conclusions: Young patients with unexplained stroke, particularly those with PFO, exhibit abnormal atrial electrical characteristics suggesting atrial arrhythmia or atrial dysfunction as a possible mechanism of stroke.

  17. The role of affect in attentional functioning for younger and older adults

    Directory of Open Access Journals (Sweden)

    Soo Rim eNoh

    2012-08-01

    Full Text Available Although previous research has shown that positive affect (PA and negative affect (NA modulate attentional functioning in distinct ways, few studies have considered whether the links between affect and attentional functioning may vary as a function of age. Using the Attention Network Test (Fan, McCandliss, Sommer, Raz, & Posner, 2002, we tested whether participants’ current state of PA and NA influenced distinct attentional functions (i.e., alerting, orienting, and executive attention and how the relationships between affective states and attentional functioning differ in younger (18-25 yrs and older (60-85 yrs age groups. The results revealed that higher PA was associated with lower alerting efficiency; however, this pattern did not vary by age group. While there were age differences in alerting efficiency, these age differences were mediated by PA, indicating that the higher state PA found in older adults may contribute to age differences in alerting. Furthermore, age group moderated the relationship between PA and orienting as well as NA and orienting. That is, higher levels of PA and lower levels of NA were associated with enhanced orienting efficiency in older adults. Neither PA nor NA had any influence on executive attention. The current results suggest that positive and negative affect may influence attentional functioning in distinct ways, but that these patterns may depend on age groups.

  18. Incidence and survival differences of differentiated thyroid cancer among younger women

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    Boltz MM

    2013-11-01

    Full Text Available Melissa M Boltz,1 Laura M Enomoto,1,2 Rollyn M Ornstein,3 Brian D Saunders,1,4 Christopher S Hollenbeak1,2,51Department of Surgery, 2Division of Outcomes Research and Quality, The Pennsylvania State University, College of Medicine, 3Department of Pediatrics, Division of Adolescent Medicine and Eating Disorders, The Pennsylvania State University, Hershey Children’s Hospital, 4Division of General Surgery Specialties and Surgical Oncology, 5Department of Public Health Sciences, The Pennsylvania State University, College of Medicine, Hershey, PA, USAAbstract: Differentiated thyroid cancer is the most common endocrine malignancy, with an estimated 60,220 new cases diagnosed in the United States in 2013. For reasons that are unclear, differentiated thyroid cancer is three times more common in females than in males. However, among adolescent and young adult females between ages 15–39 years, differentiated thyroid cancer remains under-recognized. The disparity in cancer incidence and outcomes in this population may be secondary to the tumor's biology, and risk factors unique to women. This review summarizes the incidence and survival rates of thyroid cancer in women younger than 45 years of age, as well as the pathophysiology, etiology, risk factors, prognosis, and current and emerging treatment options for this patient population.Keywords: differentiated thyroid cancer, young adult women, adolescents, incidence, risk factors, treatment

  19. Aquifer parameter identification by the best chromosome clone plus younger generation chromosome prepotency genetic algorithm

    Institute of Scientific and Technical Information of China (English)

    LI Jing-sheng; LI Kai; YAO Lei-hua

    2005-01-01

    This paper developed an improved combinatorial method called the best chromosome clone plus younger generation chromosome prepotency genetic algorithm (BCC-YGCP-GA) to evaluate aquifer parameters. This method is based on a decimal simple genetic algorithm (SGA). A synthetic example for unsteady-state flow in a two-dimensional, inhomogeneous, confined aquifer containing three hydraulically distinct zones, is used to develop data to test the model. The simulation utilizes SGA and BCC-YGCP-GA coupled to the finite element method to identify the mean zonal hydraulic conductivities, and storage coefficients of the three-compartment model. For this geometrically simple model, used as a prototype of more complex systems, the SGA does not reach convergence within 100 generations. Conversely, the convergence rate of the BCC-YGCD-GA model is very fast. The objective function value calculated by BCC-YGCD-GA is reduced to 1/1 000th of the starting value within 100 generations,and the hydraulic conductivity and storage of three zones are within a few percent of the "true" values of the ideal model, highlighting the power of the method for aquifer parameterization.

  20. Interviews with candidates for president transmitted

    Directory of Open Access Journals (Sweden)

    Wilson Gomes

    2012-07-01

    Full Text Available In election years, television interviews with presidential candidates, broadcast live, i.e. without the use of editing, have become an important genre of journalistic representation in Brazilian political campaigns. These interviews are conducted in network studios by well-known Brazilian news anchors. The fact that these interviews are transmitted directly to the electorate in an unedited form is generally offered as a guarantee of a genuine, authentic portrayal of the candidates themselves. The present work proposes that live network candidate interviews, rather than a means of political presentation on television, are actually an arena in which the institution of journalism attempts to use rhetorical and argumentative means to control the candidates’ discourse without relying on the traditional advantages conferred in daily news coverage.

  1. The general age of leadership: older-looking presidential candidates win elections during war.

    Directory of Open Access Journals (Sweden)

    Brian R Spisak

    Full Text Available As nation-state leaders age they increasingly engage in inter-state militarized disputes yet in industrialized societies a steady decrease in testosterone associated with aging is observed--which suggests a decrease in dominance behavior. The current paper points out that from modern societies to Old World monkeys increasing both in age and social status encourages dominant strategies to maintain acquired rank. Moreover, it is argued this consistency has shaped an implicit prototype causing followers to associate older age with dominance leadership. It is shown that (i faces of older leaders are preferred during intergroup conflict and (ii morphing U.S. Presidential candidates to appear older or younger has an overriding effect on actual election outcomes. This indicates that democratic voting can be systematically adjusted by activating innate biases. These findings appear to create a new line of research regarding the biology of leadership and contextual cues of age.

  2. The general age of leadership: older-looking presidential candidates win elections during war.

    Science.gov (United States)

    Spisak, Brian R

    2012-01-01

    As nation-state leaders age they increasingly engage in inter-state militarized disputes yet in industrialized societies a steady decrease in testosterone associated with aging is observed--which suggests a decrease in dominance behavior. The current paper points out that from modern societies to Old World monkeys increasing both in age and social status encourages dominant strategies to maintain acquired rank. Moreover, it is argued this consistency has shaped an implicit prototype causing followers to associate older age with dominance leadership. It is shown that (i) faces of older leaders are preferred during intergroup conflict and (ii) morphing U.S. Presidential candidates to appear older or younger has an overriding effect on actual election outcomes. This indicates that democratic voting can be systematically adjusted by activating innate biases. These findings appear to create a new line of research regarding the biology of leadership and contextual cues of age.

  3. Tectono-magmatic evolution of the younger Gardar southern rift, South Greenland

    Directory of Open Access Journals (Sweden)

    Brian G.J. Upton

    2013-11-01

    Full Text Available The 1300–1140 Ma Gardar period in South Greenland involved continental rifting, sedimentation and alkaline magmatism. The latest magmatism was located along two parallel rift zones, Isortoq–Nunarsuit in the north and the Tuttutooq–Ilimmaasaq–Narsarsuaq zone in the south addressed here. The intrusive rocks crystallised at a depth of <4 km and are essentially undisturbed by later events. Magmatism in the southern zone began with the emplacement of two giant, ≤800 m wide dykes and involved intrusion of transitional olivine basaltic, high Al/Ca magmas crystallising to troctolitic gabbros. These relatively reduced magmas evolved through marked iron enrichment to alkaline salic differentiates. In the Older giant dyke complex, undersaturated augite syenites grade into sodalite foyaite. The larger, c. 1163 Ma Younger giant dyke complex (YGDC mainly consists of structureless troctolite with localised developments of layered cumulates. A layered pluton (Klokkenis considered to be coeval and presumably comagmatic with the YGDC. At the unconformitybetween the Ketilidian basement and Gardar rift deposits, the YGDC expanded into a gabbroic lopolith. Its magma may represent a sample from a great, underplated mafic magma reservoir, parental to all the salic alkaline rocks in the southern rift. The bulk of these are silica undersaturated; oversaturated differentiates are probably products of combined fractional crystallisation and crustalassimilation.A major dyke swarm 1–15 km broad was intruded during declining crustal extension, with decreasing dyke widths and increasing differentiation over time. Intersection of the dyke swarm and E–W-trending sinistral faults controlled the emplacement of at least three central complexes (Narssaq, South Qôroq and early Igdlerfigssalik. Three post-extensional complexes (Tugtutôq,Ilímaussaq and late Igdlerfigssalik along the former rift mark the end of magmatism at c. 1140 Ma. The latter two complexes have

  4. Candidal Leukoplakia on Patient with Removable Denture

    Directory of Open Access Journals (Sweden)

    Shiril Paskalis

    2013-07-01

    Full Text Available Candida infection is a common problem in patients using removable dentures, with the most frequent type is denture stomatitis. But other type of candidal infection could also happen in these patients, such as candidal leukoplakia. We reported a 61 years old female patient who complained a painful lesion under her lower removable denture. Oral examination revealed white plaque that could not be rubbed over an ulcer on the lingual part of alveolar processes under the lower removable denture plate, and also an erythematous area on palatum durum above the upper full denture. The patient was suspected to have candidal leukoplakia on the lingual part of the mandible and denture stomatitis on the palate area. The treatment consisted of nystatin oral suspension, chlorhexidine solution, multivitamins, along with denture replacement and oral health education. The entire lesion resolved within 2 months therapy. Candidal infection treatment on denture patient needs not only medication or denture replacement, but also patient compliance to achieve maximal result.

  5. Fuzzy Treatment of Candidate Outliers in Measurements

    Directory of Open Access Journals (Sweden)

    Giampaolo E. D'Errico

    2012-01-01

    Full Text Available Robustness against the possible occurrence of outlying observations is critical to the performance of a measurement process. Open questions relevant to statistical testing for candidate outliers are reviewed. A novel fuzzy logic approach is developed and exemplified in a metrology context. A simulation procedure is presented and discussed by comparing fuzzy versus probabilistic models.

  6. Candidate genes in ocular dominance plasticity

    NARCIS (Netherlands)

    M.L. Rietman; J.-P. Sommeijer; C.N. Levelt; J.A. Heimel; A.B. Brussaard; J.G.G. Borst; Y. Elgersma; N. Galjart; G.T. van der Horst; C.M. Pennartz; A.B. Smit; B.M. Spruijt; M. Verhage; C.I. de Zeeuw

    2012-01-01

    Many studies have been devoted to the identification of genes involved in experience-dependent plasticity in the visual cortex. To discover new candidate genes, we have reexamined data from one such study on ocular dominance (OD) plasticity in recombinant inbred BXD mouse strains. We have correlated

  7. Secondary Teacher Candidates' Lesson Planning Learning

    Science.gov (United States)

    Santoyo, Christina; Zhang, Shaoan

    2016-01-01

    Teacher candidates (TCs) use clinical experiences to enact concepts taught in their university courses; therefore field experiences may be the most important component of teacher preparation (Hammerness et al., 2005). TCs require support and guidance as they learn to adapt curriculum materials for effective use in the classroom (Davis, 2006). They…

  8. Teacher Candidate Portfolios: Routine or Reflective Action?

    Science.gov (United States)

    McIntyre, Christie; Dangel, Julie Rainer

    2009-01-01

    Documentation is sparse regarding outcomes associated with teacher education portfolios and the quality of the reflections contained within the portfolios. This collective case study of six teacher candidates enrolled in an elementary teacher education program at a large midwestern university explores the outcomes of developing a portfolio based…

  9. Query by image example: The CANDID approach

    Energy Technology Data Exchange (ETDEWEB)

    Kelly, P.M.; Cannon, M. [Los Alamos National Lab., NM (United States). Computer Research and Applications Group; Hush, D.R. [Univ. of New Mexico, Albuquerque, NM (United States). Dept. of Electrical and Computer Engineering

    1995-02-01

    CANDID (Comparison Algorithm for Navigating Digital Image Databases) was developed to enable content-based retrieval of digital imagery from large databases using a query-by-example methodology. A user provides an example image to the system, and images in the database that are similar to that example are retrieved. The development of CANDID was inspired by the N-gram approach to document fingerprinting, where a ``global signature`` is computed for every document in a database and these signatures are compared to one another to determine the similarity between any two documents. CANDID computes a global signature for every image in a database, where the signature is derived from various image features such as localized texture, shape, or color information. A distance between probability density functions of feature vectors is then used to compare signatures. In this paper, the authors present CANDID and highlight two results from their current research: subtracting a ``background`` signature from every signature in a database in an attempt to improve system performance when using inner-product similarity measures, and visualizing the contribution of individual pixels in the matching process. These ideas are applicable to any histogram-based comparison technique.

  10. Emotional Intelligence and Beginning Teacher Candidates

    Science.gov (United States)

    Justice, Madeline; Espinoza, Sue

    2007-01-01

    According to the Bureau of Labor Statistics, Texas will need over 82,000 new teachers by 2008. Many teachers are leaving the profession within 5 years of being employed. Closing a revolving door, teacher preparation programs are discussing this phenomenon. One hundred sixty beginning teacher candidates were surveyed using the Emotional Skills…

  11. Spectroscopy of Hyades L dwarf candidates

    CERN Document Server

    Lodieu, N; Bejar, V J S

    2014-01-01

    We present the results of photometric, astrometric, and spectroscopic follow-up of L dwarf candidates identified in the Hyades cluster by Hogan et al. (2008). We obtained low-resolution optical spectroscopy with the OSIRIS spectrograph on the Gran Telescopio de Canarias for all 12 L dwarf candidates as well as new J-band imaging for a subsample of eight to confirm their proper motion. We also present mid-infrared photometry from the Wise Field Infrared Survey Explorer (WISE) for the Hyades L and T dwarf candidates and estimate their spectroscopic distances, effective temperatures, and masses. We confirm the cool nature of several L dwarf candidates and confirm astrometrically their membership, bridging the gap between the coolest M dwarfs and the two T dwarfs previously reported in the Hyades cluster. These members represent valuable spectral templates at an age of 625 Myr and slightly super solar metallicity (Fe/H=+0.13). We update the Hyades mass function across the hydrogen-burning limit and in the substel...

  12. Microlensing Binaries with Candidate Brown Dwarf Companions

    DEFF Research Database (Denmark)

    Shin, I.-G; Han, C.; Gould, A.;

    2012-01-01

    Brown dwarfs are important objects because they may provide a missing link between stars and planets, two populations that have dramatically different formation histories. In this paper, we present the candidate binaries with brown dwarf companions that are found by analyzing binary microlensing ...

  13. Towards Treating Chemistry Teacher Candidates as Human

    Science.gov (United States)

    Lewthwaite, Brian Ellis

    2008-01-01

    This research inquiry investigates the factors influencing chemistry teacher candidates' development during their extended practica in the second and final year of an After-Degree Bachelor of Education at a university in central Canada. A variety of data sources are used to identify the risk and protective factors impeding and contributing to the…

  14. Promoting Team Leadership Skills in Doctoral Candidates

    Science.gov (United States)

    Suleiman, Mahmoud; Whetton, Danny

    2014-01-01

    Doctoral programs can serve as an optimal opportunity for candidates to engage in tasks and activities to transform them and their schools. The paradigm shifts in such preparation involve moving from sitting and getting to making and taking. Most importantly, it requires building leadership skills and styles necessary to bring about desired change…

  15. Teacher Candidate Disposition: Moral Judgement or Regurgitation?

    Science.gov (United States)

    Johnson, Lisa E.

    2008-01-01

    Developing teacher candidates who are able to make moral judgements to equitably resolve classroom dilemmas, conduct student assessment and allocate resources is critical for today's diverse classrooms and should be part of fostering professional disposition. However, one challenge of incorporating dispositions in teacher education and a valid…

  16. Gallium-67 imaging in candidal esophagitis

    Energy Technology Data Exchange (ETDEWEB)

    Rundback, J.H.; Goldfarb, C.R.; Ongseng, F. (Beth Israel Medical Center, New York, NY (USA))

    1990-01-01

    Ga-67 scanning has been used to evaluate esophageal carcinoma. It has demonstrated candidal infection in other body sites and, in one previous case, in the esophagus. The authors present a case of diffuse esophageal uptake of Ga-67 in esophageal candidiasis.

  17. 76 FR 36130 - Call for Candidates

    Science.gov (United States)

    2011-06-21

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ACCOUNTING STANDARDS ADVISORY BOARD Call for Candidates AGENCY: Federal Accounting Standards Advisory Board. ACTION: Request for... Accounting Standards Advisory Board (FASAB or the Board) with the requested materials in response to...

  18. 11 CFR 9003.2 - Candidate certifications.

    Science.gov (United States)

    2010-01-01

    ... excess of the aggregate payments to which they will be entitled under 11 CFR part 9004. (2) That no... funds under 11 CFR 9003.2(c)(3) shall not count against such candidate's $50,000 expenditure limitation... expenditures in excess of the limitations of 11 CFR 110.8(a), the Commission may seek civil penalties under...

  19. Organisational age cultures : The interplay of chief executive officers age and attitudes toward younger and older employees

    NARCIS (Netherlands)

    Zacher, Hannes; Gielnik, Michael M.

    2014-01-01

    This article investigates the interactive effects of chief executive officer (CEO) age and CEO attitudes toward younger and older employees on organisational age cultures. Data was collected from 66 CEOs of small and medium-sized businesses and 274 employees. Results were consistent with expectation

  20. Individual differences in cognitive functioning predict effectiveness of a heads-up lane departure warning for younger and older drivers.

    Science.gov (United States)

    Aksan, Nazan; Sager, Lauren; Hacker, Sarah; Lester, Benjamin; Dawson, Jeffrey; Rizzo, Matthew; Ebe, Kazutoshi; Foley, James

    2017-02-01

    The effectiveness of an idealized lane departure warning (LDW) was evaluated in an interactive fixed base driving simulator. Thirty-eight older (mean age=77years) and 40 younger drivers (mean age=35years) took four different drives/routes similar in road culture composition and hazards encountered with and without LDW. The four drives were administered over visits separated approximately by two weeks to examine changes in long-term effectiveness of LDW. Performance metrics were number of LDW activations and average correction time to each LDW. LDW reduced correction time to re-center the vehicle by 1.34s on average (95% CI=1.12-1.57s) but did not reduce the number of times the drivers drifted enough in their lanes to activate the system (LDW activations). The magnitude of reductions in average correction RT was similar for older and younger drivers and did not change with repeated exposures across visits. The contribution of individual differences in basic visual and motor function, as well as cognitive function to safety gains from LDW was also examined. Cognitive speed of processing predicted lane keeping performance for older and younger drivers. Differences in memory, visuospatial construction, and executive function tended to predict performance differences among older but not younger drivers. Cognitive functioning did not predict changes in the magnitude of safety benefits from LDW over time. Implications are discussed with respect to real-world safety systems.

  1. Changes in Female Support Network Systems and Adaptation after Breast Cancer Diagnosis: Differences between Older and Younger Patients

    Science.gov (United States)

    Ashida, Sato; Palmquist, Aunchalee E. L.; Basen-Engquist, Karen; Singletary, S. Eva; Koehly, Laura M.

    2009-01-01

    Purpose: This study evaluates the changes in social networks of older and younger breast cancer patients over a 6-month period following their first diagnosis and how such modifications are associated with changes in the patients' mood state. Design and Methods: Newly diagnosed breast cancer patients were interviewed shortly after their diagnosis…

  2. Mortality, Recurrence, and Dependency Rates Are Higher after Acute Ischemic Stroke in Elderly Patients with Diabetes Compared to Younger Patients.

    Science.gov (United States)

    Long, Xue; Lou, Yongzhong; Gu, Hongfei; Guo, Xiaofei; Wang, Tao; Zhu, Yanxia; Zhao, Wenjuan; Ning, Xianjia; Li, Bin; Wang, Jinghua; An, Zhongping

    2016-01-01

    Stroke has a greater effect on the elderly than on younger patients. However, the long-term outcomes associated with stroke among elderly patients with diabetes are unknown. We aimed to assess the differences in long-term outcomes between young and elderly stroke patients with diabetes. A total of 3,615 acute ischemic stroke patients with diabetes were recruited for this study between 2006 and 2014. Outcomes at 12 and 36 months after stroke (including mortality, recurrence, and dependency) were compared between younger (age alcohol consumers. Mortality, dependency, and recurrence rates at 12 months after stroke were 19.0, 48.5, and 20.9% in the elderly group and 7.4, 30.9, and 15.4% in the younger group, respectively (all P dependency, and recurrence rates at 12 and 36 months after stroke were significantly higher in the elderly group than in the younger group after adjusting for stroke subtypes, stroke severity, and risk factors. Odds ratios (95% confidence interval) at 12 and 36 months after stroke were 2.18 (1.64-2.89) and 3.10 (2.35-4.08), respectively, for mortality, all P dependency, all P dependency after stroke.

  3. Comparison of Younger and Older Adults' Acceptability of Treatment for Generalized Anxiety Disorder Co-Occurring with Parkinson's Disease

    Science.gov (United States)

    Lundervold, Duane A.; Ament, Patrick A.; Holt, Peter S.; Hunt, Lauren S.

    2013-01-01

    Acceptability ratings of medication or Behavioral Relaxation Training (BRT), for general anxiety disorder (GAD) co-occurring with Parkinson's Disease (PD) were obtained from younger ("n" = 79) and older ("n" = 54) adults. Participants read a case description of an older adult with PD and comorbid GAD followed by a description…

  4. Sex Matters Less for Younger Faculty: Evidence of Desegregate Pay Disparities from the 1988 and 1993 NCES Surveys.

    Science.gov (United States)

    Toutkoushian, Robert K.

    1998-01-01

    Uses data from 1988 and 1993 National Center for Education Statistics surveys of faculty to examine what has happened to earnings of women in higher education. Data show the aggregate unexplained wage gap between men and women is between 7% and 10%. Wage gap for younger women is much lower than for older women in academe, suggesting some progress…

  5. Memory for age-face associations in younger and older adults: the role of generation and schematic support.

    Science.gov (United States)

    McGillivray, Shannon; Castel, Alan D

    2010-12-01

    Memory for ages of unfamiliar faces was examined in an associative memory task to determine whether generation as well as schematic support (cues from faces) would enhance later cued recall of the age information and reduce older adults' associative deficit. Participants studied faces and were either presented with the age or first had to guess before being shown the correct age. Later, participants were given a cued-recall test. Both younger and older adults exhibited associative memory enhancements from first generating the ages at encoding (a generation effect) despite the fact the initial generation was often inaccurate. Although older adults recalled fewer ages overall compared with younger adults, older adults were able to remember the age information for older faces equally as well as younger adults. However, when errors committed during generation were large and when schematic support was not available to support encoding and retrieval (when the age information was inconsistent given the cues from the face), generating was no longer beneficial for either older or younger adults. Thus, although older adults display an associative deficit when remembering specific age-face associations, this can be reduced through the use of prior knowledge and generation at encoding.

  6. Age-related differences in brain electrical activity during extended continuous face recognition in younger children, older children and adults

    NARCIS (Netherlands)

    J.W. van Strien (Jan); J.C. Glimmerveen (Johanna C.); I.H.A. Franken (Ingmar); V.E. Martens (Vanessa E.G.); E.A. de Bruin (Eveline)

    2011-01-01

    textabstractTo examine the development of recognition memory in primary-school children, 36 healthy younger children (8-9years old) and 36 healthy older children (11-12years old) participated in an ERP study with an extended continuous face recognition task (Study 1). Each face of a series of 30 fac

  7. A comparison of health outcomes in older versus younger adults following a road traffic crash injury: a cohort study.

    Directory of Open Access Journals (Sweden)

    Bamini Gopinath

    Full Text Available Given the aging demographics of most developed countries, understanding the public health impact of mild/moderate road traffic crash injuries in older adults is important. We aimed to determine whether health outcomes (pain severity and quality of life measures over 24 months differ significantly between older (65+ and younger adults (18-64.Prospective cohort study of 364, 284 and 252 participants with mild/moderate injury following a vehicle collision at baseline, 12 and 24 months, respectively. A telephone-administered questionnaire obtained information on socio-economic, pre- and post-injury psychological and heath characteristics.At baseline, there were 55 (15.1% and 309 (84.9% participants aged ≥65 and 18-64 years, respectively. At 12- and 24-month follow-up, older compared to younger participants who had sustained a mild/moderate musculoskeletal injury had lower physical functioning (3.9-units lower Short Form-12 Physical Composite Score, multivariable-adjusted p = 0.03 at both examinations. After multivariable adjustment, older (n = 45 versus younger (n = 207 participants had lower self-perceived health status (8.1-units lower European Quality of Life-5 Dimensions Visual Acuity Scale scores at 24 months, p = 0.03, 24 months later.Older compared to younger participants who sustained a mild/moderate injury following a road-traffic crash demonstrated poorer physical functioning and general health at 24 months.

  8. Predictive Validity of ICD-10 Hyperkinetic Disorder Relative to DSM-IV Attention-Deficit/Hyperactivity Disorder among Younger Children

    Science.gov (United States)

    Lahey, Benjamin B.; Pelham, William E.; Chronis, Andrea; Massetti, Greta; Kipp, Heidi; Ehrhardt, Ashley; Lee, Steve S.

    2006-01-01

    Background: Little is known about the predictive validity of hyperkinetic disorder (HKD) as defined by the Diagnostic Criteria for Research for mental and behavioral disorders of the tenth edition of the International Classification of Diseases (ICD-10; World Health Organization, 1993), particularly when the diagnosis is given to younger children.…

  9. Comparison of Provision of Stroke Care in Younger and Older Patients: Findings from the South London Stroke Register

    Directory of Open Access Journals (Sweden)

    Siobhan L. Crichton

    2012-01-01

    Full Text Available Background. Evidence-based stroke care should be available to all patients. However, evidence exists of inequalities according to age. This study compared access to care for younger adults to that for over 65s. Methods. Using population-based data from 4229 patients with first-ever stroke between 1995 and 2010, associations between age and 21 care indicators were investigated using multivariable logistic regression. Results. Age was not associated with stroke unit admission for ischaemic stroke (P=0.666. Younger PICH patients were least likely to be admitted to stroke units (P=0.001, instead treated on neurosurgical or ICU wards. Younger age was also associated with admission to neurosurgery or ICU after SAH (P=0.006, increased occupational or physiotherapy at 1 year (P=0.043, and contact with a GP 3 months after stroke (P<0.001. Conclusion. Younger patients have equal or greater access to evidence-based care. However, there is a need to ensure that services meet the needs of this group.

  10. What do younger and older workers want to accomplish? Age-related differences in content and characteristics of occupational goals

    NARCIS (Netherlands)

    Zacher, Hannes; Degner, Manuela; Seevaldt, Robert; Frese, Michael; Luedde, Joerg

    2009-01-01

    Demographic changes necessitate that companies commit younger workers and motivate older workers through work design. Age-related differences in occupational goals should be taken into account when accomplishing these challenges. In this study, we investigated goal contents and goal characteristics

  11. Age-Related Differences in Brain Electrical Activity during Extended Continuous Face Recognition in Younger Children, Older Children and Adults

    Science.gov (United States)

    Van Strien, Jan W.; Glimmerveen, Johanna C.; Franken, Ingmar H. A.; Martens, Vanessa E. G.; de Bruin, Eveline A.

    2011-01-01

    To examine the development of recognition memory in primary-school children, 36 healthy younger children (8-9 years old) and 36 healthy older children (11-12 years old) participated in an ERP study with an extended continuous face recognition task (Study 1). Each face of a series of 30 faces was shown randomly six times interspersed with…

  12. Relationships between walking and percentiles of adiposity inolder and younger men

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Paul T.

    2005-06-01

    To assess the relationship of weekly walking distance to percentiles of adiposity in elders (age {ge} 75 years), seniors (55 {le} age <75 years), middle-age men (35 {le} age <55 years), and younger men (18 {le} age <35 years old). Cross-sectional analyses of baseline questionnaires from 7,082 male participants of the National Walkers Health Study. The walkers BMIs were inversely and significantly associated with walking distance (kg/m{sup 2} per km/wk) in elders (slope {+-} SE: -0.032 {+-} 0.008), seniors (-0.045 {+-} 0.005), and middle-aged men (-0.037 {+-} 0.007), as were their waist circumferences (-0.091 {+-} 0.025, -0.045 {+-} 0.005, and -0.091 {+-} 0.015 cm per km/wk, respectively), and these slopes remained significant when adjusted statistically for reported weekly servings of meat, fish, fruit, and alcohol. The declines in BMI associated with walking distance were greater at the higher than lower percentiles of the BMI distribution. Specifically, compared to the decline at the 10th BMI percentile, the decline in BMI at the 90th percentile was 5.1-fold greater in elders, 5.9-fold greater in seniors, and 6.7-fold greater in middle-age men. The declines in waist circumference associated with walking distance were also greater among men with broader waistlines. Exercise-induced weight loss (or self-selection) causes an inverse relationship between adiposity and walking distance in men 35 and older that is substantially greater among fatter men.

  13. Anterior knee pain in younger adults as a precursor to subsequent patellofemoral osteoarthritis: a systematic review

    Directory of Open Access Journals (Sweden)

    Thomas Martin J

    2010-09-01

    Full Text Available Abstract Background Patellofemoral osteoarthritis (PFOA is a common form of knee OA in middle and older age, but its relation to PF disorders and symptoms earlier in life is unclear. Our aim was to conduct a systematic review to investigate the strength of evidence for an association between anterior knee pain (AKP in younger adults and subsequent PFOA. Methods The search strategy included electronic databases (Pubmed, EMBASE, AMED, CINAHL, Cochrane, PEDro, SportDiscus: inception to December 2009, reference lists of potentially eligible studies and selected reviews. Full text articles in any language, - identified via English titles and abstracts, were included if they were retrospective or prospective in design and contained quantitative data regarding structural changes indicative of PFOA, incident to original idiopathic AKP. Eligibility criteria were applied to titles, abstracts and full-texts by two independent reviewers. Data extraction included study location, design, date, sampling procedure, sample characteristics, AKP/PFOA definitions, follow-up duration and rate, and main findings. Foreign language articles were translated into English prior to examination. Results Seven articles satisfied eligibility (5 English, 2 German. Only one case-control study directly investigated a link between PFOA and prior AKP, providing level 3b evidence in favour of an association (OR 4.4; 95%CI 1.8, 10.6. Rough estimates of the annual risk of PFOA from the remaining six small, uncontrolled, observational studies (mean follow-up range: 5.7 to 23 years ranged from 0% to 3.4%. This was not the primary aim of these studies, and limitations in design and methodology mean this data should be interpreted with caution. Conclusions There is a paucity of high-quality evidence reporting a link between AKP and PFOA. Further, well-designed cohort studies may be able to fill this evidence gap.

  14. Frequency of intrathoracic injuries in children younger than 3 years with rib fractures

    Energy Technology Data Exchange (ETDEWEB)

    Darling, Stephen E. [Kapiolani Children' s Hospital, The Department of Radiology, Honolulu, HI (United States); Done, Stephen L.; Friedman, Seth D. [Seattle Children' s Hospital, The Department' s of Radiology, Seattle, WA (United States); University of Washington School of Medicine, Seattle, WA (United States); Feldman, Kenneth W. [Seattle Children' s Hospital, Pediatrics, General Pediatrics Division, Seattle, WA (United States); Seattle Children' s Protection Program, Children' s Protection Program, M/S M2-10, Seattle, WA (United States); University of Washington School of Medicine, Seattle, WA (United States)

    2014-10-15

    Research documents that among children admitted to trauma intensive care units the number of rib fractures sustained indicates the child's likelihood of having and severity of intrathoracic injury. This has been misused in court to argue that children with multiple rib fractures who lack intrathoracic injury have abnormal bone fragility rather than inflicted injury. To determine frequency of intrathoracic injuries in children younger than 3 years with rib fractures in cases of child abuse and accidental trauma. We conducted a retrospective review of rib fractures caused by documented abuse or accidents from 2003 to 2010 in children treated at Seattle Children's Hospital and Harborview Medical Center. A senior pediatric radiologist and radiology fellow independently reviewed the imaging. Children with bone demineralization were excluded. Descriptive and simple comparative statistics were used. Seventy-two percent (47/65) of infants and toddlers with rib fractures were abused. Abused children had more rib fractures than accidentally injured children (5.55 vs. 3.11, P = 0.012). However intrathoracic injuries as a whole (55.6% vs. 12.8%, P < 0.001) and individual types of intrathoracic injuries were more common with accidents. Rates of other thoracic cage injuries did not differ substantially (27.8% accidents vs. 12.8% abuse, P = 0.064). Intracranial and intra-abdominal injuries and skull fractures were equally frequent, but other extrathoracic fractures were more common with abuse (70.2% vs. 16.7%, P < 0.001). Abused infants and toddlers have fewer intrathoracic injuries but more rib fractures than accidentally injured peers. This likely reflects different injury mechanics. Lack of intrathoracic injuries in abused children with rib fractures does not imply bone fragility. (orig.)

  15. The impact of xerostomia on oral-health-related quality of life among younger adults

    Directory of Open Access Journals (Sweden)

    Broadbent Jonathan M

    2006-11-01

    Full Text Available Abstract Background Recent research has suggested that chronic dry mouth affects the day-to-day lives of older people living in institutions. The condition has usually been considered to be a feature of old age, but recent work by our team produced the somewhat surprising finding that 10% of people in their early thirties are affected. This raises the issue of whether dry mouth is a trivial condition or a more substantial threat to quality of life among younger people. The objective of this study was to examine the association between xerostomia and oral-health-related quality of life among young adults while controlling for clinical oral health status and other potential confounding factors. Methods Cross-sectional analysis of data from a longstanding prospective observational study of a Dunedin (New Zealand birth cohort: clinical dental examinations and questionnaires were used at age 32. The main measures were xerostomia (the subjective feeling of dry mouth, measured with a single question and oral-health-related quality of life (OHRQoL measured using the short-form Oral Health Impact Profile (OHIP-14. Results Of the 923 participants (48.9% female, one in ten were categorised as 'xerostomic', with no apparent gender difference. There was a strong association between xerostomia and OHRQoL (across all OHIP-14 domains which persisted after multivariate analysis to control for clinical characteristics, gender, smoking status and personality characteristics (negative emotionality and positive emotionality. Conclusion Xerostomia is not a trivial condition; it appears to have marked and consistent effects on sufferers' day-to-day lives.

  16. Elevated lung cancer in younger adults and low concentrations of arsenic in water.

    Science.gov (United States)

    Steinmaus, Craig; Ferreccio, Catterina; Yuan, Yan; Acevedo, Johanna; González, Francisca; Perez, Liliana; Cortés, Sandra; Balmes, John R; Liaw, Jane; Smith, Allan H

    2014-12-01

    Arsenic concentrations greater than 100 µg/L in drinking water are a known cause of cancer, but the risks associated with lower concentrations are less well understood. The unusual geology and good information on past exposure found in northern Chile are key advantages for investigating the potential long-term effects of arsenic. We performed a case-control study of lung cancer from 2007 to 2010 in areas of northern Chile that had a wide range of arsenic concentrations in drinking water. Previously, we reported evidence of elevated cancer risks at arsenic concentrations greater than 100 µg/L. In the present study, we restricted analyses to the 92 cases and 288 population-based controls who were exposed to concentrations less than 100 µg/L. After adjustment for age, sex, and smoking behavior, these exposures from 40 or more years ago resulted in odds ratios for lung cancer of 1.00, 1.43 (90% confidence interval: 0.82, 2.52), and 2.01 (90% confidence interval: 1.14, 3.52) for increasing tertiles of arsenic exposure, respectively (P for trend = 0.02). Mean arsenic water concentrations in these tertiles were 6.5, 23.0, and 58.6 µg/L. For subjects younger than 65 years of age, the corresponding odds ratios were 1.00, 1.62 (90% confidence interval: 0.67, 3.90), and 3.41 (90% confidence interval: 1.51, 7.70). Adjustments for occupation, fruit and vegetable intake, and socioeconomic status had little impact on the results. These findings provide new evidence that arsenic water concentrations less than 100 µg/L are associated with higher risks of lung cancer.

  17. Forefoot Surgery in Elderly Compared With Younger Patient Populations: Complications and Type of Procedure.

    Science.gov (United States)

    Vermersch, Thibault; Fessy, Michel Henri; Besse, Jean-Luc

    2015-01-01

    In forefoot surgery, the presenting complaints and expected benefits differ between elderly and younger patients. The present study mapped forefoot procedures recommended to elderly patients compared with those recommended to the general population and assessed the complications according to age group and comorbidity. Consecutive patients were included in a single-center, continuous, retrospective case-control study. Three age groups were defined: <65 years, 65 to 74 years, and ≥ 75 years. All patients, regardless of age, underwent the same procedure; elderly-specific techniques such as the Keller procedure were not used. A total of 321 patients were included, with a mean age of 60.6 (range 16 to 86) years. A similar procedure was used in all 3 groups, but at differing frequencies, with arthrodesis and minor procedures increasing with increasing patient age. In all 3 groups, in the population as a whole, the incidence of delayed healing, deep infection, and nonunion was 9%, 1%, and 2%, respectively. These complications were independent of age group. In the <65-year-old group, just as in the study population as a whole, arthrodesis associated with resection arthroplasty resulted in greater rates of delayed healing and deep infection. The complications rates were equivalent among the 3 age groups. Major surgical procedures should be avoided in elderly patients, if possible. However, no particular procedure is contraindicated in the elderly, although the method of fixation must be robust owing to the frequency of osteoporosis. A first step would be to achieve consensus on the age threshold for "elderliness."

  18. Privileging Younger Children's Voices in Research: Use of Drawings and a Co-Construction Process

    Directory of Open Access Journals (Sweden)

    Joanna Tay-Lim PhD Student

    2013-02-01

    Full Text Available The growing acknowledgement of the value of listening to children's views and experiences in social research, popularly termed as “listening to their voices,” brings with it methodological consequences. Regarding children as expert informants about their own lives carries with it the simultaneous call for researchers to be experts in developing and employing appropriate strategies that can effectively elicit the insights that children can bring to a research topic. With younger children, the use of participatory methodologies has been foregrounded as the key to unlocking their potential to contribute rich and useful perspectives to inform research into their lives. This article explores the usefulness of employing preschoolers' drawings within the context of a co-construction process to facilitate the children's construction of ideas and reinforce their voices in research. The case is made that the quality of the dialogical engagement is as important as the drawing itself, and both visual images and the verbal exchanges are central to the children's meaning-making process. In the co-construction process, both adult and child are (ideally equal players and the resulting dialogical process plays a major role in the constitution of the phenomena. The role of the researcher as the co-constructor can be a challenging one because it entails engaging and supporting children's views and the expression of these views. The discussion and illustrations from the first author's research projects contribute to the literature base on positioning preschool children as valid social actors in their communities. We operate through an ethos of empowerment of all participants, and aim for participatory research practice which has at its heart an active involvement in promoting the rights of children as citizens with voice and power. (Pascal & Bertram, 2009, p. 249

  19. Younger is not always better: development of locomotor adaptation from childhood to adulthood.

    Science.gov (United States)

    Vasudevan, Erin V L; Torres-Oviedo, Gelsy; Morton, Susanne M; Yang, Jaynie F; Bastian, Amy J

    2011-02-23

    New walking patterns can be learned over short timescales (i.e., adapted in minutes) using a split-belt treadmill that controls the speed of each leg independently. This leads to storage of a modified spatial and temporal motor pattern that is expressed as an aftereffect in regular walking conditions. Because split-belt walking is a novel task for adults and children alike, we used it to investigate how motor adaptation matures during human development. We also asked whether the immature pattern resembles that of people with cerebellar dysfunction, because we know that this adaptation depends on cerebellar integrity. Healthy children (3-18 years old) and adults, and individuals with cerebellar damage were adapted while walking on split belts (1:2 speed ratio). Adaptation and de-adaptation rates were quantified separately for temporal and spatial parameters. All healthy children and adults tested could learn the new timing at the same rate and showed significant aftereffects. However, children younger than 6 years old were unable to learn the new spatial coordination. Furthermore, children as old as age 11 years old showed slower rates of adaptation and de-adaptation of spatial parameters of walking. Young children showed patterns similar to cerebellar patients, with greater deficits in spatial versus temporal adaptation. Thus, although walking is a well-practiced, refined motor skill by late childhood (i.e., 11 years of age), the processes underlying learning new spatial relationships between the legs are still developing. The maturation of locomotor adaptation follows at least two time courses, which we propose is determined by the developmental state of the cerebellum.

  20. Candidate genes in ocular dominance plasticity

    Directory of Open Access Journals (Sweden)

    M. Liset Rietman

    2012-02-01

    Full Text Available The objective of this study was to identify new candidate genes involved in experience-dependent plasticity. To this aim, we combined previously obtained data from recombinant inbred BXD strains on ocular dominance (OD plasticity and gene expression levels in the neocortex. We validated our approach using a list of genes which alter OD plasticity when inactivated. The expression levels of one fifth of these genes correlated with the amount of OD plasticity. Moreover, the two genes with the highest relative inter-strain differences were among the correlated genes. This suggests that correlation between gene expression levels and OD plasticity is indeed likely to point to genes with a causal role in modulating or generating plasticity in the visual cortex. After this validation on known plasticity genes, we identified new candidate genes by a multi-step approach. First, a list was compiled of all genes of which the expression level in BXD strains correlate with the amount of OD plasticity. To narrow this list to the more promising candidates, we took its cross-section with a list of genes co-regulated with the sensitive period for OD plasticity and a list of genes associated with pathways implicated in OD plasticity. This analysis resulted in a list of 32 candidate genes. The list contained unproven, but not surprising, candidates, such as the genes for IGF-1, NCAM1, NOGO-A, the gamma2 subunit of the GABA(A receptor, acetylcholine esterase and the catalytic subunit of cAMP-dependent protein kinase A. This was indicative of the viability of our approach, but more interesting were the novel candidate genes: Akap7, Akt1, Camk2d, Cckbr, Cd44, Crim1, Ctdsp2, Dnajc5, Gnai1, Itpka, Mapk8, Nbea, Nfatc3, Nlk, Npy5r, Phf21a, Phip, Ppm1l, Ppp1r1b, Rbbp4, Slc1a3, Slit2, Socs2, Spock3, St8sia1, Zfp207. The possible role of some of these candidates is discussed in the article.

  1. Relationship of blood pressure, behavioral mood state, and physical activity following caffeine ingestion in younger and older women.

    Science.gov (United States)

    Arciero, Paul J; Ormsbee, Michael J

    2009-08-01

    The purpose of this study was to examine the age-related differences in blood pressure, heart rate, and behavioral mood state after caffeine ingestion in younger and older women. Using a placebo-controlled, double-blind design, 10 younger (Y; 18-22 years) and 10 older (O; 50-67 years) healthy women who were moderate consumers of caffeine (self-reported mean intake: Y, 139 +/- 152 mg.day-1; O, 204 +/- 101 mg.day-1) were investigated. All volunteers were characterized for fasting plasma glucose, insulin, free-fatty acids and caffeine levels, body composition, cardiovascular fitness, physical activity, and energy intake. Before and after placebo and caffeine ingestion (5 mg.kg-1 fat-free mass; approximately 208-270 mg) test days, the following variables were measured in all subjects: plasma caffeine levels, heart rate, blood pressure, and behavioral mood state. Results showed that, following caffeine ingestion: (i) both systolic and diastolic blood pressure (SBP and DBP, respectively) increased significantly (p older women (SBP, 128.4 +/- 14.2 vs. 132.1 +/- 13.0 mm Hg (3%); DBP, 80.2 +/- 6.9 vs. 83.4 +/- 7.5 mm Hg (4%), whereas only DBP increased in the younger women (67.1 +/- 4.7 vs. 69.9 +/- 5.4 mm Hg (4.2%); p older women. Self-reported level of physical activity was inversely related to change in DBP following caffeine ingestion in younger women. In conclusion, blood pressure response is augmented and subjective feelings of behavioral mood state are attenuated to a greater degree in older than in younger women following acute caffeine ingestion. Less physically active younger women are more vulnerable to the pressor response to caffeine than more active younger women. It should be noted that these findings are limited to moderate consumers of caffeine who abstained for 48 h prior to testing, and who ingested caffeine in pill form (approximately 240 mg).

  2. Spatial-sequential working memory in younger and older adults: age predicts backward recall performance within both age groups

    Directory of Open Access Journals (Sweden)

    Louise A. Brown

    2016-10-01

    Full Text Available Working memory is vulnerable to age-related decline, but there is debate regarding the age-sensitivity of different forms of spatial-sequential working memory task, depending on their passive or active nature. The functional architecture of spatial working memory was therefore explored in younger (18-40 years and older (64-85 years adults, using passive and active recall tasks. Spatial working memory was assessed using a modified version of the Spatial Span subtest of the Wechsler Memory Scale – Third Edition (WMS-III; Wechsler, 1998. Across both age groups, the effects of interference (control, visual, or spatial, and recall type (forward and backward, were investigated. There was a clear effect of age group, with younger adults demonstrating a larger spatial working memory capacity than the older adults overall. There was also a specific effect of interference, with the spatial interference task (spatial tapping reliably reducing performance relative to both the control and visual interference (dynamic visual noise conditions in both age groups and both recall types. This suggests that younger and older adults have similar dependence upon active spatial rehearsal, and that both forward and backward recall require this processing capacity. Linear regression analyses were then carried out within each age group, to assess the predictors of performance in each recall format (forward and backward. Specifically the backward recall task was significantly predicted by age, within both the younger and older adult groups. This finding supports previous literature showing lifespan linear declines in spatial-sequential working memory, and in working memory tasks from other domains, but contrasts with previous evidence that backward spatial span is no more sensitive to aging than forward span. The study suggests that backward spatial span is indeed more processing-intensive than forward span, even when both tasks include a retention period, and that age

  3. DEVELOPMENT OF QUESTIONNAIRE FOR MEASURING FACTORS OF SIGNIFICANCE OF AN ELDERLY PERSON AS ANOTHER FOR THE YOUNGER GENERATION

    Directory of Open Access Journals (Sweden)

    Natalia V. KHALINA

    2015-01-01

    Full Text Available Social and political processes of the present time, actualize in the minds of the younger generation of Russians importance for the development of the country. But it would be wrong to assume no significant experience in the elderly and to consider identity apart from family ties. Relevance to this key acts the process of intergenerational transmission, when the younger generation can assimilate the experience of close, meaningful elderly. The paper drew attention to the dedicated A.V. Petrovsky importance of interpersonal factors: credibility (reference, attraction (emotional state, institutionalized role (power status. On the basis of the three-factor model proposed by the author's questionnaire for measuring factors like the importance of an elderly as a significant Another for the younger generation. The authors conducted a tested methodology for determining the significance of an old man for youth. The statistical analysis survey was conducted using a Rasch model, which is an important feature of the subjective objectivity of assessments. It shows the process of correction of the questionnaire based on the theory of measurement of latent variables. Designed questionnaire contains twenty-four judgments, respondents were asked to express the degree of agreement with these judgments in four grades. Thus, twenty-four indicator variables actually measure the latent variable "importance of the elderly as a significant Another for the younger generation", and are compatible with each other, enabling them to measure the factors, the importance of the elderly as a significant Another for the younger generation: the authority of the (reference, attraction (emotional status institutionalized the role of (status of power.

  4. Spatial-Sequential Working Memory in Younger and Older Adults: Age Predicts Backward Recall Performance within Both Age Groups

    Science.gov (United States)

    Brown, Louise A.

    2016-01-01

    Working memory is vulnerable to age-related decline, but there is debate regarding the age-sensitivity of different forms of spatial-sequential working memory task, depending on their passive or active nature. The functional architecture of spatial working memory was therefore explored in younger (18–40 years) and older (64–85 years) adults, using passive and active recall tasks. Spatial working memory was assessed using a modified version of the Spatial Span subtest of the Wechsler Memory Scale – Third Edition (WMS-III; Wechsler, 1998). Across both age groups, the effects of interference (control, visual, or spatial), and recall type (forward and backward), were investigated. There was a clear effect of age group, with younger adults demonstrating a larger spatial working memory capacity than the older adults overall. There was also a specific effect of interference, with the spatial interference task (spatial tapping) reliably reducing performance relative to both the control and visual interference (dynamic visual noise) conditions in both age groups and both recall types. This suggests that younger and older adults have similar dependence upon active spatial rehearsal, and that both forward and backward recall require this processing capacity. Linear regression analyses were then carried out within each age group, to assess the predictors of performance in each recall format (forward and backward). Specifically the backward recall task was significantly predicted by age, within both the younger and older adult groups. This finding supports previous literature showing lifespan linear declines in spatial-sequential working memory, and in working memory tasks from other domains, but contrasts with previous evidence that backward spatial span is no more sensitive to aging than forward span. The study suggests that backward spatial span is indeed more processing-intensive than forward span, even when both tasks include a retention period, and that age predicts

  5. Biological characteristics and clinical outcome of triple negative primary breast cancer in older women - comparison with their younger counterparts.

    Directory of Open Access Journals (Sweden)

    Binafsha M Syed

    Full Text Available Triple negative (ER, PgR and HER2 negative breast cancers (TNBCs are often considered as a poor prognostic phenotype. There is dearth of evidence showing the prevalence and biological behaviour of TNBCs in older women. This study aimed to analyse their biological characteristics in comparison with a well characterised younger series from a single centre with long term clinical follow-up. Over 37 years (1973-2010, 1,758 older (≥70 years women with early operable (<5 cm primary breast cancer were managed in a dedicated clinic and have complete clinical information available. Of these 813 patients underwent primary surgery and 575 had good quality tumour samples available for tissue microarray analysis using indirect immunohistochemistry. A total of 127 patients (22.1% had TNBCs and full biological analysis of 15 biomarkers was performed. The results were compared with those of their younger (<70 years counterparts 342 (18.9% from a previously characterised, consecutive series of primary breast cancer treated in the same unit (1986-1998. The 127 older patients with TNBCs showed lower rates of Ki67 and CK 7/8 positivity and high rates of bcl2 and CK18 positivity when compared with their younger counterparts (p<0.05. There was no significant difference in the long term clinical outcome between the two age groups, despite the fact that 47% of the younger patients had adjuvant chemotherapy, while none in the older cohort received such treatment. EGFR, axillary stage and pathological size showed prognostic significance in older women with TNBCs on univariate analysis. Despite not having received adjuvant chemotherapy, the older series had clinical outcome similar to the younger patients almost half of whom had chemotherapy. This appears to be related to other biomarkers (in addition to ER/PgR/HER2 eg Ki67, bcl2 and cytokeratins which have different expression patterns influencing prognosis.

  6. Role of spinal ultrasound in diagnosis of meningitis in infants younger than 6 months

    Energy Technology Data Exchange (ETDEWEB)

    Nepal, Pankaj, E-mail: pankaj-123@live.com [Department of Radiodiagnosis and Imaging, Sector-12, Chandigarh 160012 (India); Sodhi, Kushaljit Singh, E-mail: sodhiks@gmail.com [Department of Radiodiagnosis and Imaging, Sector-12, Chandigarh 160012 (India); Saxena, Akshay Kumar, E-mail: fatakshay@yahoo.com [Department of Radiodiagnosis and Imaging, Sector-12, Chandigarh 160012 (India); Bhatia, Anmol, E-mail: anmol_bhatia26@yahoo.co.in [Department of Radiodiagnosis and Imaging, Sector-12, Chandigarh 160012 (India); Singhi, Sunit, E-mail: sunit.singhi@gmail.com [Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh 160012 (India); Khandelwal, Niranjan, E-mail: khandelwaln@hotmail.com [Department of Radiodiagnosis and Imaging, Sector-12, Chandigarh 160012 (India)

    2015-03-15

    Highlights: •This was a prospective study to evaluate role of spinal ultrasound (US) in 60 infants (<6 months of age) with clinically suspected meningitis. •On ultrasound examination, we evaluated echogenicity and /or trabeculations in the posterior subarachnoid space and spinal cord pulsations. •Results of spinal US were evaluated in correlation with cerebrospinal fluid analysis. •Results of our study show presence of echogenicity/trabeculations in posterior subarachnoid space or abnormal pulsations of spinal cord and nerve roots are significantly associated with meningitis with a high specificity and positive predictive value in its diagnosis. •Spinal ultrasound can be used as a radiation free imaging modality to detect meningitis. -- Abstract: Background: Spinal ultrasound (US) can detect changes in CSF echogenicity and decreased cord pulsations which reflect the inflammatory changes in meningitis. Till date, there is no published data about the prospective accuracy of spinal US in meningitis. Objective: To assess accuracy of spinal US in diagnosis of meningitis in infants younger than 6 months. Methods: This was an institute ethics committee approved prospective study carried out in infants less than 6 months of age with clinical suspicion of meningitis who presented to pediatric emergency unit. 60 infants each in study and control group were enrolled. US of thoraco-lumbar spine were performed prior to lumbar puncture in all cases. We looked for the presence of echogenicity or trabeculations in posterior subarachnoid space and for presence or absence of spinal cord and nerve root pulsations on real time ultrasound. The results of spinal US were evaluated in correlation with cerebrospinal fluid analysis. Follow up ultrasounds were done in infants who showed abnormal findings after the initiation of treatment and findings compared with initial results. Results: The study group comprised of 40 boys and 20 girls with mean age of 47.85 days. The control

  7. Differences in dual-task performance and prefrontal cortex activation between younger and older adults

    Directory of Open Access Journals (Sweden)

    Ohsugi Hironori

    2013-01-01

    Full Text Available Abstract Background The purpose of this study was to examine task-related changes in prefrontal cortex (PFC activity during a dual-task in both healthy young and older adults and compare patterns of activation between the age groups. We also sought to determine whether brain activation during a dual-task relates to executive/attentional function and how measured factors associated with both of these functions vary between older and younger adults. Results Thirty-five healthy volunteers (20 young and 15 elderly participated in this study. Near-infrared spectroscopy (NIRS was employed to measure PFC activation during a single-task (performing calculations or stepping and dual-task (performing both single-tasks at once. Cognitive function was assessed in the older patients with the Trail-making test part B (TMT-B. Major outcomes were task performance, brain activation during task (oxygenated haemoglobin: Oxy-Hb measured by NIRS, and TMT-B score. Mixed ANOVAs were used to compare task factors and age groups in task performance. Mixed ANOVAs also compared task factors, age group and time factors in task-induced changes in measured Oxy-Hb. Among the older participants, correlations between the TMT-B score and Oxy-Hb values measured in each single-task and in the dual-task were examined using a Pearson correlation coefficient. Oxy-Hb values were significantly increased in both the calculation task and the dual-task within patients in both age groups. However, the Oxy-Hb values associated with there were higher in the older group during the post-task period for the dual-task. Also, there were significant negative correlations between both task-performance accuracy and Oxy-Hb values during the dual-task and participant TMT-B scores. Conclusions Older adults demonstrated age-specific PFC activation in response to dual-task challenge. There was also a significant negative correlation between PFC activation during dual-task and executive

  8. Spectroscopic follow up of Kepler planet candidates

    DEFF Research Database (Denmark)

    Latham..[], D. W.; Cochran, W. D.; Marcy, G.W.

    2010-01-01

    Spectroscopic follow-up observations play a crucial role in the confirmation and characterization of transiting planet candidates identified by Kepler. The most challenging part of this work is the determination of radial velocities with a precision approaching 1 m/s in order to derive masses from...... spectroscopic orbits. The most precious resource for this work is HIRES on Keck I, to be joined by HARPS-North on the William Herschel Telescope when that new spectrometer comes on line in two years. Because a large fraction of the planet candidates are in fact stellar systems involving eclipsing stars...... and not planets, our strategy is to start with reconnaissance spectroscopy using smaller telescopes, to sort out and reject as many of the false positives as possible before going to Keck. During the first Kepler observing season in 2009, more than 100 nights of telescope time were allocated for this work, using...

  9. Attitudes of Teacher Candidates Towards Teaching Profession

    Directory of Open Access Journals (Sweden)

    Aykut Emre BOZDOĞAN

    2007-12-01

    Full Text Available The objective of this study is to determine the attitudes of teacher candidates regarding teaching profession from the point of view of different variables. This study was taken place at Ahi Ervan University Teachers’ College in 2006-2007 year of education and 181 Applied science and Social science students participated it. In order to obtain the data of the research scanning method entitled “Determination of Attitude Towards Teaching Profession” was used which was developed by Aşkar and Erden (1987 . During the analysis of the research data SPSS 12.0 program and the necessary statistical methods were used to analize the data of the research. As a result of the research it is understood that the attitudes of teacher candidates change according to sex and factor that made them to choose the department they study.

  10. Candidate Species Selection: Cultural and Photosynthetic Aspects

    Science.gov (United States)

    Mitchell, C. A.

    1982-01-01

    Cultural information is provided for a data base that will be used to select candidate crop species for a controlled ecological life support system (CELSS). Lists of food crops which will satisfy most nutritional requirements of humans and also fit within the scope of cultural restrictions that logically would apply to a closed, regenerating system were generated. Cultural and environmental conditions that will allow the most rapid production of edible biomass from candidate species in the shortest possible time are identified. Cultivars which are most productive in terms of edible biomass production by (CE) conditions, and which respond to the ever-closed approach to optimization realized by each shortened production cycle are selected. The experimental approach with lettuce was to grow the crop hydroponically in a growth chamber and to manipulate such variables as light level and duration, day/night temperature, and nutrient form and level in the solution culture.

  11. New drug candidates in tuberculosis treatment

    Directory of Open Access Journals (Sweden)

    Begüm Evranos Aksöz

    2014-12-01

    makes them quit the treatment. From these problems emerges the need for development of effective new drugs, with smaller duration of therapy, less side effects and without the problem of resistance. After a long period such as 40 years, a new drug molecule bedaquiline was approved in December 2012 by FDA while the drug was in phase II research. Bedaquiline will be used in multidrug resistant tuberculosis therapy. When the chemical structures of bedaquilline and other candidate drugs were examined, the structures such as diarylquinoline, oxazolidinone, nitroimidazole, ethylenediamine drew attention. These common structures will be directive in designing new molecules. In this review, bedaquiline and other candidate drug molecules such as sutezolide, linezolide, PA-824, delamanide, rifapentine, gatifloxacin, moxifloxacin, BTZ-043, TBA-354, CPZEN-45, DC-159a, Q201, SQ-609, SQ-641 were mentioned.

  12. Decision Analysis of Advanced Scout Helicopter Candidates

    Science.gov (United States)

    1980-01-01

    assist the ASH SSG by constructing a comprehensive ASH evaluation model utilizing multi-attribute utility assessment ( MAUA ) modeling. ~~UA is a forre...results are included as well. The output of the MAUA model is a numerical representation of the worth of each ASH candidate. These numbers are...instance of a methodology called Multi-Attribute Utility Analysis ( MAUA ). In general, MAUA is characterized by the represen- tation of outcomes in terms

  13. Optical durability testing of candidate solar mirrors

    Energy Technology Data Exchange (ETDEWEB)

    Jorgensen, G.; Kennedy, C.; King, D.; Terwilliger, K.

    2000-03-24

    Durability testing of a variety of candidate solar reflector materials at outdoor test sites and in laboratory accelerated weathering chambers is the main activity within the Advanced Materials task of the Concentrated Solar Power (CSP) Program. Outdoor exposure testing (OET) at up to eight outdoor, worldwide exposure sites has been underway for several years. This includes collaboration under the auspices of the International Energy Agency (IEA) Solar Power and Chemical Energy Systems (SolarPACES) agreement. Outdoor sites are fully instrumented in terms of monitoring meteorological conditions and solar irradiance. Candidate materials are optically characterized prior to being subjected to exposure in real and simulated weathering environments. Optical durability is quantified by periodically re-measuring hemispherical and specular reflectance as a function of exposure time. By closely monitoring the site- and time-dependent environmental stress conditions experienced by the material samples, site-dependent loss of performance may be quantified. In addition, accelerated exposure testing (AET) of these materials in parallel under laboratory-controlled conditions may permit correlating the outdoor results with AET, and subsequently predicting service lifetimes. Test results to date for a large number of candidate solar reflector materials are presented in this report. Acronyms are defined. Based upon OET and AET results to date, conclusions can be drawn about the optical durability of the candidate reflector materials. The optical durability of thin glass, thick glass, and two metallized polymers can be characterized as excellent. The all-polymeric construction, several of the aluminized reflectors, and a metallized polymer can be characterized as having intermediate durability and require further improvement, testing and evaluation, or both.

  14. Sensitive Radio Survey of Obscured Quasar Candidates

    CERN Document Server

    Alexandroff, Rachael M; van Velzen, Sjoert; Greene, Jenny E; Strauss, Michael A

    2016-01-01

    We study the radio properties of moderately obscured quasars over a range of redshifts to understand the role of radio activity in accretion using the Jansky Very Large Array (JVLA) at 6.0GHz and 1.4GHz. Our z~2.5 sample consists of optically-selected obscured quasar candidates, all of which are radio-quiet, with typical radio luminosities of $\

  15. Release of uranium from candidate wasteforms

    OpenAIRE

    Collier, N.; Harrison, M.; Brogden, M,; Hanson, B

    2012-01-01

    Large volumes of depleted natural and low-enriched uranium exist in the UK waste inventory. This work reports on initial investigations of the leaching performance of candidate glass and cement encapsulation matrices containing UO3 powder as well as that of uranium oxide powders. The surface areas of UO3 powder and the monolith samples of UO3 conditioned in the glass and cement matrices were very different making leaching comparisons difficult. The results showed that for both types of monoli...

  16. Alcoholism and Alternative Splicing of Candidate Genes

    OpenAIRE

    Toshikazu Sasabe; Shoichi Ishiura

    2010-01-01

    Gene expression studies have shown that expression patterns of several genes have changed during the development of alcoholism. Gene expression is regulated not only at the level of transcription but also through alternative splicing of pre-mRNA. In this review, we discuss some of the evidence suggesting that alternative splicing of candidate genes such as DRD2 (encoding dopamine D2 receptor) may form the basis of the mechanisms underlying the pathophysiology of alcoholism. These reports sugg...

  17. ATTITUDES OF ENGLISH TEACHER CANDIDATES TOWARD ICT

    OpenAIRE

    HİSMANOGLU, Murat; HİSMANOGLU, Sibel; Hismanoglu, Murat; HISMANOGLU, Sibel

    2010-01-01

    The purpose of this study was to investigate the attitudes of English teacher candidates at formal and distance higher education contexts toward ICT and reveal whether there was a significant difference between these two groups in terms of their attitudes toward ICT. The sample of the study consisted of 175 prospective English teachers at two different higher education contexts. The participants were randomly selected among forth-year students at the ELT departments of Euopean University of L...

  18. ATTITUDES OF ENGLISH TEACHER CANDIDATES TOWARD ICT

    OpenAIRE

    Hismanoglu, Murat; HISMANOGLU, Sibel

    2011-01-01

    The purpose of this study was to investigate the attitudes of English teacher candidates at formal and distance higher education contexts toward ICT and reveal whether there was a significant difference between these two groups in terms of their attitudes toward ICT. The sample of the study consisted of 175 prospective English teachers at two different higher education contexts. The participants were randomly selected among forth-year students at the ELT departments of Euopean University of L...

  19. Searching for candidate genes for male infertility

    Institute of Scientific and Technical Information of China (English)

    B.N.Truong; E.K.Moses; J.E.Armes; D.J.Venter; H.W.G.Baker

    2003-01-01

    Aim: We describe an approach to search for candidate genes for male infertility using the two human genome databases: the public University of California at Santa Cruz (UCSC) and private Celera databases which list known and predicted gene sequences and provide related information such as gene function, tissue expression,known mutations and single nucleotide polymorphisms (SNPs). Methods and Results: To demonstrate this in silico research, the following male infertility candidate genes were selected: (1) human BOULE, mutations of which may lead to germ cell arrest at the primary spermatocyte stage, (2) mutations of casein kinase 2 alpha genes which may cause globozoospermia, (3) DMR-N9 which is possibly involved in the spermatogenic defect of myotonic dystrophy and (4) several testes expressed genes at or near the breakpoints of a balanced translocation associated with hypospermatogenesis. We indicate how information derived from the human genome databases can be used to confirm these candidate genes may be pathogenic by studying RNA expression in tissue arrays using in situ hybridization and gene sequencing. Conclusion: The paper explains the new approach to discovering genetic causes of male infertility using information about the human genome. ( Asian J Andro1 2003 Jun; 5:137-147 )

  20. Nuclear safety in EU candidate countries

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-10-01

    Nuclear safety in the candidate countries to the European Union is a major issue that needs to be addressed in the framework of the enlargement process. Therefore WENRA members considered it was their duty to offer their technical assistance to their Governments and the European Union Institutions. They decided to express their collective opinion on nuclear safety in those candidate countries having at least one nuclear power plant: Bulgaria, the Czech Republic, Hungary, Lithuania, Romania, Slovakia and Slovenia. The report is structured as follows: A foreword including background information, structure of the report and the methodology used, General conclusions of WENRA members reflecting their collective opinion, For each candidate country, an executive summary, a chapter on the status of the regulatory regime and regulatory body, and a chapter on the nuclear power plant safety status. Two annexes are added to address the generic safety characteristics and safety issues for RBMK and VVER plants. The report does not cover radiation protection and decommissioning issues, while safety aspects of spent fuel and radioactive waste management are only covered as regards on-site provisions. In order to produce this report, WENRA used different means: For the chapters on the regulatory regimes and regulatory bodies, experts from WENRA did the work. For the chapters on nuclear power plant safety status, experts from WENRA and from French and German technical support organisations did the work. Taking into account the contents of these chapters, WENRA has formulated its general conclusions in this report.

  1. Molecular candidates of MTV in air

    Science.gov (United States)

    Dam, Nico; Mirzaei, Mehrnoosh; van de Water, Willem

    2011-11-01

    In molecular tagging velocimetry (MTV), the molecules of a gas are used as flow tracers. These tracers can be produced at will by illumination with a laser which promotes molecules to a long- lived excited state, fuses N2 and N2 to NO, or makes molecules phosphoresce. A while later these tagged molecules can be visualized by laser-induced fluorescence, or by just watching them while they phosphoresce. Candidates for MTV in turbulence research must be arranged in structures narrower than the Kolmogorov scale, which remain narrow as time progresses, and must live longer than the Kolmogorov time. These requirements invalidate many candidates, candidates once deemed successful. They do so in various surprising manners that involve a combination of fluid flow and molecular dynamics. Rather than velocimetry in turbulence, MTV techniques offer a unique view on basic dispersion processes at the smallest scales of turbulence. In this way we have measured the spreading of clouds whose size is a few times the Kolmogorov length and the Batchelor dispersion of objects whose size is inside the inertial range.

  2. MBM12: A Close, Younger Version of the TW Hydrae Association

    Science.gov (United States)

    Wolk, S. J.; Hearty, T.; Jayawardhana, R.

    2000-01-01

    MBM 12 is a dark cloud located about 65 pc from the sun. During the late 1980's and early 1990's, five Classical T Tauri stars were discovered associated with the cloud. The co-existence of the cloud and several stars with disks implies a very young association, very close to the earth. Such an association would be in a league with TWA and Eta Cham. However, at an estimated age of about 1 Myrs. Brown dwarfs/Jupiters would be brighter and disk should be more numerous. Deep ROSAT images and follow up spectroscopic observations raised the cluster membership to 8. We have expanded on this study with deep groundbased imaging, followup spectroscopy and infrared data. We discuss our current data base of U through I observations (complete to V=20) J through K observations (complete to K=14) and spectra of most stars above V magnitude 15. We will present a mass function for the about 40 stars now identified with the association and discuss disk, binary and brown dwarf candidates.

  3. UNCOVERING THE NUCLEUS CANDIDATE FOR NGC 253

    Energy Technology Data Exchange (ETDEWEB)

    Günthardt, G. I.; Camperi, J. A. [Observatorio Astronómico, Universidad Nacional de Córdoba (Argentina); Agüero, M. P. [Observatorio Astronómico, Universidad Nacional de Córdoba, and CONICET (Argentina); Díaz, R. J.; Gomez, P. L.; Schirmer, M. [Gemini Observatory, AURA (United States); Bosch, G., E-mail: gunth@oac.uncor.edu, E-mail: camperi@oac.uncor.edu, E-mail: mpaguero@oac.uncor.edu, E-mail: rdiaz@gemini.edu, E-mail: pgomez@gemini.edu, E-mail: mschirmer@gemini.edu, E-mail: guille@fcaglp.unlp.edu.ar [Instituto de Astrofísica de La Plata (CONICET-UNLP) (Argentina)

    2015-11-15

    NGC 253 is the nearest spiral galaxy with a nuclear starburst that becomes the best candidate for studying the relationship between starburst and active galactic nucleus activity. However, this central region is veiled by large amounts of dust, and it has been so far unclear which is the true dynamical nucleus to the point that there is no strong evidence that the galaxy harbors a supermassive black hole co-evolving with the starburst as was supposed earlier. Near-infrared (NIR) spectroscopy, especially NIR emission line analysis, could be advantageous in shedding light on the true nucleus identity. Using Flamingos-2 at Gemini South we have taken deep K-band spectra along the major axis of the central structure and through the brightest infrared source. In this work, we present evidence showing that the brightest NIR and mid-infrared source in the central region, already known as radio source TH7 and so far considered just a large stellar supercluster, in fact presents various symptoms of a genuine galactic nucleus. Therefore, it should be considered a valid nucleus candidate. Mentioning some distinctive aspects, it is the most massive compact infrared object in the central region, located at 2.″0 of the symmetry center of the galactic bar, as measured in the K-band emission. Moreover, our data indicate that this object is surrounded by a large circumnuclear stellar disk and it is also located at the rotation center of the large molecular gas disk of NGC 253. Furthermore, a kinematic residual appears in the H{sub 2} rotation curve with a sinusoidal shape consistent with an outflow centered in the candidate nucleus position. The maximum outflow velocity is located about 14 pc from TH7, which is consistent with the radius of a shell detected around the nucleus candidate, observed at 18.3 μm (Qa) and 12.8 μm ([Ne ii]) with T-ReCS. Also, the Brγ emission line profile shows a pronounced blueshift and this emission line also has the highest equivalent width at this

  4. Switching of auditory attention in "cocktail-party" listening: ERP evidence of cueing effects in younger and older adults.

    Science.gov (United States)

    Getzmann, Stephan; Jasny, Julian; Falkenstein, Michael

    2017-02-01

    Verbal communication in a "cocktail-party situation" is a major challenge for the auditory system. In particular, changes in target speaker usually result in declined speech perception. Here, we investigated whether speech cues indicating a subsequent change in target speaker reduce the costs of switching in younger and older adults. We employed event-related potential (ERP) measures and a speech perception task, in which sequences of short words were simultaneously presented by four speakers. Changes in target speaker were either unpredictable or semantically cued by a word within the target stream. Cued changes resulted in a less decreased performance than uncued changes in both age groups. The ERP analysis revealed shorter latencies in the change-related N400 and late positive complex (LPC) after cued changes, suggesting an acceleration in context updating and attention switching. Thus, both younger and older listeners used semantic cues to prepare changes in speaker setting.

  5. A report of two cases of splenectomy in children younger than two years old with hereditary spherocytosis

    Directory of Open Access Journals (Sweden)

    Sheng Jin

    2015-02-01

    Full Text Available Hereditary spherocytosis (HS is a common pediatric hemolytic anemia and one of the most common types of familial hemolytic anemia caused by congenital red blood cell defects. HS often presents clinically as childhood anemia, jaundice, and progressive splenomegaly. It is generally accepted that splenectomy is the most effective treatment for HS, but development of overwhelming infections with symptoms such as chills, high fever, and septicemia may occur because of immune dysfunction after splenectomy. As a result, the generally proposed age for children to undergo splenectomy is after 5 years of age. Splenectomy in younger HS patients is rarely reported. Here, however, we report 2 cases of HS in children younger than 2 years of age (15 months and 18 months who underwent splenectomy; we also report on their follow-up.

  6. Penfigoide bolhoso no adulto mais jovem: relato de três casos Bullous pemphigoid in younger adults: three case reports

    Directory of Open Access Journals (Sweden)

    Roberta Richter Zanella

    2011-04-01

    Full Text Available O penfigoide bolhoso é uma dermatose bolhosa autoimune subepidérmica, mais comumente observada na população idosa (acima dos 70 anos. Autoanticorpos são formados contra antígenos específicos da zona de membrana basal: BP180 e BP230 (proteínas do hemidesmossomo. Apresentamos três casos de penfigoide bolhoso, em adultos com menos de 50 anos de idade, destacan do as peculiaridades clínicas na faixa etária mais jovem.Bullous pemphigoid is an autoimmune subepidermal bullous dermatosis more commonly observed in the elderly (over 70 years old. Autoantibodies are produced for specific antigens of the epidermal basement membrane zone: BP 180 and BP 230 (hemidesmosome proteins. We report three cases of bullous pemphigoid in adults younger than 50 years old, discussing the clinical characteristics of the disease in younger patients.

  7. Comparing the effects of Osteoporosis Prevention Exercise Protocol (OPEP) versus walking in the prevention of osteoporosis in younger females

    OpenAIRE

    Soomro, Rabail Rani; Ahmed, Syed Imran; Khan, Muhammad; Ali, Syed Shahzad

    2015-01-01

    Objective: The aim of this work was to evaluate the effectiveness of Osteoporosis Prevention Exercise Protocol (OPEP) in younger females. Methods: One hundred young female volunteers aged 20-30 were selected from IPM&R Dow University of Health Sciences. This was a comparative study in which 64 females participants were randomly assigned into two groups (32 in OPEP exercise group and 32 in walking group). The exercise session had three components 1) stretching 2) strengthening 3) high impact w...

  8. A prospective pilot study: Can the biliary tree be visualized in children younger than 3 months on Magnetic Resonance Cholangiopancreatography?

    Energy Technology Data Exchange (ETDEWEB)

    Siles, Pascale [La Timone Children' s Hospital, Department of Radiology, Marseille (France); Aschero, Audrey; Gorincour, Guillaume; Bourliere-Najean, Brigitte; Petit, Philippe [La Timone Children' s Hospital, Department of Pediatric Radiology, Marseille (France); Roquelaure, Bertrand [La Timone Children' s Hospital, Department of Pediatrics, Marseille (France); Delarue, Arnauld [La Timone Children' s Hospital, Department of Pediatric Surgery, Marseille (France)

    2014-09-15

    Magnetic resonance cholangiopancreatography (MRCP) could aid in the diagnosis of biliary atresia, a hepatic pathology with thin, irregular or interrupted biliary ducts. There is little published evidence of MRCP appearances in normal neonates and young infants. To assess the use of MR cholangiopancreatography in visualizing the biliary tree in neonates and infants younger than 3 months with no hepatobiliary disorder, and to assess this visibility in relationship to the child's age, weight, and sedation and fasting states. Between December 2008 and October 2010 our department performed MRI of the brain, orbits and face on 16 full-term neonates and infants. Each child was younger than 3 months (90 days) and without any hepatobiliary disorders. The children were scanned with a respiratory-gated 0.54 x 0.51 x 0.4-mm{sup 3} 3-D MRCP sequence. We used a reading grid to assess subjectively the visibility of the extrahepatic bile ducts along with extrahepatic bile duct confluence. The visibility of the extrahepatic bile duct confluence was assessed against age, weight, and sedation and fasting states. The extrahepatic bile duct confluence was seen in 10 children out of 16 (62.5%). In the neonate sub-group (corrected age younger than 30 days), the MRCP was technically workable and the extrahepatic bile duct confluence was seen in four cases out of eight (50%). This visualization was up to 75% in the subgroup older than 30 days. However, statistically there was no significant difference in visibility of the extrahepatic bile duct confluence in relationship to age, weight or MRCP performance conditions (feeding, fasting or sedation). The complete normal biliary system (extrahepatic bile duct confluence included) is not consistently visualized in infants younger than 3 months old on non-enhanced MRCP. Thus the use of MRCP to exclude a diagnosis of biliary atresia is compromised at optimal time of surgery. (orig.)

  9. Age-related differences in brain electrical activity during extended continuous face recognition in younger children, older children and adults.

    Science.gov (United States)

    Van Strien, Jan W; Glimmerveen, Johanna C; Franken, Ingmar H A; Martens, Vanessa E G; de Bruin, Eveline A

    2011-09-01

    To examine the development of recognition memory in primary-school children, 36 healthy younger children (8-9 years old) and 36 healthy older children (11-12 years old) participated in an ERP study with an extended continuous face recognition task (Study 1). Each face of a series of 30 faces was shown randomly six times interspersed with distracter faces. The children were required to make old vs. new decisions. Older children responded faster than younger children, but younger children exhibited a steeper decrease in latencies across the five repetitions. Older children exhibited better accuracy for new faces, but there were no age differences in recognition accuracy for repeated faces. For the N2, N400 and late positive complex (LPC), we analyzed the old/new effects (repetition 1 vs. new presentation) and the extended repetition effects (repetitions 1 through 5). Compared to older children, younger children exhibited larger frontocentral N2 and N400 old/new effects. For extended face repetitions, negativity of the N2 and N400 decreased in a linear fashion in both age groups. For the LPC, an ERP component thought to reflect recollection, no significant old/new or extended repetition effects were found. Employing the same face recognition paradigm in 20 adults (Study 2), we found a significant N400 old/new effect at lateral frontal sites and a significant LPC repetition effect at parietal sites, with LPC amplitudes increasing linearly with the number of repetitions. This study clearly demonstrates differential developmental courses for the N400 and LPC pertaining to recognition memory for faces. It is concluded that face recognition in children is mediated by early and probably more automatic than conscious recognition processes. In adults, the LPC extended repetition effect indicates that adult face recognition memory is related to a conscious and graded recollection process rather than to an automatic recognition process.

  10. Assessing motor imagery ability in younger and older adults by combining measures of vividness, controllability and timing of motor imagery.

    Science.gov (United States)

    Saimpont, Arnaud; Malouin, Francine; Tousignant, Béatrice; Jackson, Philip L

    2015-02-09

    With the population aging, a large number of patients undergoing rehabilitation are older than 60 years. Also, since the use of motor imagery (MI) training in rehabilitation is becoming more popular, it is important to gain a better knowledge about the age-related changes in MI ability. The main goal of this study was to compare MI ability in younger and older adults as well as to propose a new procedure for testing this ability. Thirty healthy young subjects (mean age: 22.9±2.7 years) and 28 healthy elderly subjects (mean age: 72.4±5.5 years) participated in the experiment. They were administered three tests aimed at assessing three dimensions of MI: (1) the kinesthetic and visual imagery questionnaire (KVIQ) to assess MI vividness; (2) a finger-thumb opposition task to assess MI controllability; and (3) a chronometric task to assess the timing of MI. On average, the younger and older groups showed similar results on the KVIQ and the chronometric task, but the younger group was more accurate at the finger-thumb opposition task. Interestingly, there was a large variability in the performance within both groups, emphasizing the importance of considering each person individually regarding MI ability, whatever his age. Finally, we propose two indexes of MI ability to identify the potential of persons to engage in MI training programs. Future studies are needed to confirm the predictive value of these MI indexes and define inclusion/exclusion thresholds for their use as a screening tool in both younger and older adults.

  11. Younger or older parental age and risk of suicidality, premature death, psychiatric illness, and criminality in offspring

    OpenAIRE

    Mok, Pearl; Antonsen, Sussie; Pedersen, Carsten Bøcker; Webb, Roger

    2017-01-01

    BackgroundYounger or older parental age has been linked with a range of adverse offspring endpoints. We investigated associations between parental age and nine adverse offspring outcomes in three correlated domains: (i) Premature death: suicide, unnatural death, natural death; (ii) Psychiatric morbidity: any mental illness, suicide attempt, substance misuse; (iii) Criminality: violent offending, imprisonment, driving whilst intoxicated.MethodsPersons born in Denmark 1966–1996 were followed fr...

  12. Correlation between Interpupillary and Inner-Outer Intercanthal Distances in Individuals Younger than 20

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    Mohammad Etezad-Razavi

    2008-11-01

    Full Text Available

    PURPOSE: To determine the correlation between interpupillary distance (IPD and inner-outer intercanthal distance (IOICD and to find a regression equation for calculating IPD based on IOICD measurements. METHODS: The study subjects were randomly selected from individuals aged 3 months to 20 years who were referred to our ophthalmology clinic, health care centers and children attending kindergartens. Participants were divided into 4 age categories: younger than 3, 3-5, 5-12.5 and 12.5-20 years. IPD was measured by a PD meter (PD2, Oculus, Germany; other parameters including IOICD, nasal limbus to temporal limbus (NLTL, inner intercanthal distance (IICD and outer intercanthal distance (OICD were measured using a translucent plastic ruler. RESULTS: The study included 254 female (60.6% and 165 male (39.4% subjects with mean age of 87.7±73.2 (range 3-240 months. Significant correlation was observed between IOICD and IPD in the 3-5 yr and 12.5-20 yr age groups. In the younger than 3 and 5-12.5 year age groups, NLTL had the best correlation with IPD. The regression equations for calculating IPD according to IOICD were as follows. In male subjects, near IPD= 0.941×IOICD (r²= 0

  13. Influence of outdoor games on functional condition of the respiratory system at girls of the younger school age

    Directory of Open Access Journals (Sweden)

    Оlena Potapova

    2016-10-01

    Full Text Available Purpose: to study influence of outdoor games on functional condition of the respiratory system of girls of the younger school age in the groups of 6–8 and 9–10 years old. Material & Methods: the problem of functional condition of external breath at girls of the younger school age (in the age groups of 6–8 and 9–10 years old, who were divided into the control group (CG in number of 32persons (CS No. 58 and the experimental (EG in number of 29 persons (OTEC No. 109 of Zaporozhe, is considered. Results: it is defined that the studied girls of both groups at the beginning of the research had mainly below average and average levels of functional condition of the system of external breath. Conclusions: the effective impact of outdoor games on functional condition of the whole organism in general and on the system of external breath, in particular, at girls of the experimental group in comparison with the studied girls of the same age of the control group is proved experimentally. Application of the large number of various outdoor games allowed diversifying the program of training at physical education classes emotionally and physically, than promoted the activation of functions of the whole organism of girls of the younger school age.

  14. Memory for positive, negative and neutral events in younger and older adults: Does emotion influence binding in event memory?

    Science.gov (United States)

    Earles, Julie L; Kersten, Alan W; Vernon, Laura L; Starkings, Rachel

    2016-01-01

    When remembering an event, it is important to remember both the features of the event (e.g., a person and an action) and the connections among features (e.g., who performed which action). Emotion often enhances memory for stimulus features, but the relationship between emotion and the binding of features in memory is unclear. Younger and older adults attempted to remember events in which a person performed a negative, positive or neutral action. Memory for the action was enhanced by emotion, but emotion did not enhance the ability of participants to remember which person performed which action. Older adults were more likely than younger adults to make binding errors in which they incorrectly remembered a familiar actor performing a familiar action that had actually been performed by someone else, and this age-related associative deficit was found for both neutral and emotional actions. Emotion not only increased correct recognition of old events for older and younger adults but also increased false recognition of events in which a familiar actor performed a familiar action that had been performed by someone else. Thus, although emotion may enhance memory for the features of an event, it does not increase the accuracy of remembering who performed which action.

  15. The preservation of response inhibition aftereffects in a location-based spatial negative priming task: younger versus older adults.

    Science.gov (United States)

    Buckolz, Eric; Lok, Michael; Kajaste, Ben; Edgar, Cameron; Khan, Michael

    2015-01-01

    Younger (M = 21 years) and older (M = 74 years) adults completed a spatial negative priming (SNP) task where (central) events (i.e., target or distractor) are presented in trial pairs: first the prime and then the probe. Free-choice trials were included (1 location: 2 permissible responses), which allowed us to isolate response inhibition and its consequent inhibitory aftereffects (i.e., current inhibition interferes with later related processing-e.g., SNP). The inhibitory aftereffects associated with the suppression of responses activated by distractor-occupied locations were highly comparable for younger and older adults; including similar SNP effect sizes, a significant tendency to select against former distractor (inhibited) responses (within-hand finger options) on free-choice trials, and latency delays attributable solely to the use of self-selected distractor responses. Aftereffects generated by target-occupied prime trials locations were also the same for both age groups; recently executed target responses were selected for and produced faster responding (within hand). Aftereffects were absent on between-hand free-choice trials and, overall, response selection determinants on free-choice trials matched for older and younger adults.

  16. Expanded vs. equal interval spaced retrieval practice: exploring different schedules of spacing and retention interval in younger and older adults.

    Science.gov (United States)

    Logan, Jessica M; Balota, David A

    2008-05-01

    The present study was designed to help answer several questions regarding the impact of spacing and expanded retrieval on memory performance in younger and older adults. Three expanded/equal interval schedule pairings, matched in average spacing (1-2-3/2-2-2; 1-3-5/3-3-3; and 1-3-8/4-4-4), were compared, and the effect of retention interval on spaced retrieval benefits was examined by comparing performance on a same day test to a test delayed by 24 h. Both age groups showed a learning phase retrieval success advantage for expanded items compared to equal interval items. Only older adults in the same day test condition showed a significant expansion effect in final recall. After a 24-h delay, the final recall advantage for items in the expanded condition was lost in both groups, and in fact these items were at a significant recall disadvantage for younger adults. Results indicate that younger and older adults benefit from a rehearsal technique that incorporated any type of spaced retrieval whether it is distributed as an expanding schedule or not. Although we did not find robust advantages for expanded retrieval compared to equal interval practice, there could be certain advantages (such as reinforcement due to high success rates) to using expanded retrieval depending on the ultimate goals of an individual memory training program.

  17. Younger age at onset of sporadic Parkinson’s disease among subjects occupationally exposed to metals and pesticides

    Directory of Open Access Journals (Sweden)

    Ratner Marcia H.

    2014-09-01

    Full Text Available An earlier age at onset of Parkinson’s disease (PD has been reported to be associated with occupational exposures to manganese and hydrocarbon solvents suggesting that exposure to neurotoxic chemicals may hasten the progression of idiopathic PD. In this study the role of occupational exposure to metals and pesticides in the progression of idiopathic PD was assessed by looking at age at disease onset. The effects of heritable genetic risk factors, which may also influence age at onset, was minimized by including only sporadic cases of PD with no family history of the disease (n=58. Independent samples Student t-test revealed that subjects with occupational exposure to metals and/or pesticides (n=36 were significantly (p=0.013 younger than unexposed controls (n=22. These subjects were then divided into three groups [high (n=18, low (n=18, and unexposed (n=22] to ascertain if duration of exposure further influenced age at onset of PD. One-way ANOVA revealed that subjects in the high exposure group were significantly (p=0.0121 younger (mean age: 50.33 years than unexposed subjects (mean age: 60.45 years. Subjects were also stratified by exposure type (metals vs. pesticides. These results suggest that chronic exposure to metals and pesticides is associated with a younger age at onset of PD among patients with no family history of the disease and that duration of exposure is a factor in the magnitude of this effect.

  18. Friend or foe? Decoding the facilitative and disruptive effects of emotion on working memory in younger and older adults

    Directory of Open Access Journals (Sweden)

    Linda eTruong

    2014-02-01

    Full Text Available A growing body of work on emotion-cognition interactions has revealed both facilitative and disruptive effects of emotion on working memory in younger adults. These differing effects may vary by the goal relevancy of emotion within a task. Additionally, it is possible that these emotional effects would be larger for older adults, considering findings of preserved emotional processing with age. To test these hypotheses, the current study examined the effects of emotional content and aging on working memory for target information in the presence of distraction. Thirty-six younger (ages 18-29 and 36 older adults (ages 65-87 completed a delayed-response working memory task. Participants viewed two target words intermixed with two distracter words, and then judged whether a subsequently presented probe word was one of the target words. The emotional content (valence and arousal of targets and distracters was systematically manipulated. Results indicated that emotional targets facilitated working memory in both age groups. In contrast, emotional distracters disrupted performance. Negative distracters were particularly disruptive for older adults, but younger adults did not show an emotional interference effect. These findings help clarify discrepancies in the literature and contribute to the sparse research on emotional working memory in older adults.

  19. An fMRI comparison of neural activity associated with recognition of familiar melodies in younger and older adults

    Directory of Open Access Journals (Sweden)

    Ritu eSikka

    2015-10-01

    Full Text Available Several studies of semantic memory in non-musical domains involving recognition of items from long-term memory have shown an age-related shift from the medial temporal lobe structures to the frontal lobe. However, the effects of aging on musical semantic memory remain unexamined. We compared activation associated with recognition of familiar melodies in younger and older adults. Recognition follows successful retrieval from the musical lexicon that comprises a lifetime of learned musical phrases. We used the sparse-sampling technique in fMRI to determine the neural correlates of melody recognition by comparing activation when listening to familiar versus unfamiliar melodies, and to identify age differences. Recognition-related cortical activation was detected in the right superior temporal, bilateral inferior and superior frontal, left middle orbitofrontal, bilateral precentral, and left supramarginal gyri. Region-of-interest analysis showed greater activation for younger adults in the left superior temporal gyrus and for older adults in the left superior frontal, left angular, and bilateral superior parietal regions. Our study provides powerful evidence for these musical memory networks due to a large sample (N = 40 that includes older adults. This study is the first to investigate the neural basis of melody recognition in older adults and to compare the findings to younger adults.

  20. Higher postural heart rate increments on head-up tilt correlate with younger age but not orthostatic symptoms.

    Science.gov (United States)

    Ives, Colleen T; Kimpinski, Kurt

    2013-08-15

    Reports have shown that younger individuals present with higher postural heart rate increments on head-up tilt (HUT). However, a correlation between the degree of heart rate increment and symptoms of orthostatic intolerance has not been determined. The objective of this study was to determine whether higher postural heart rate increments during HUT correlate with symptoms of orthostatic intolerance in healthy subjects. Postural heart rate increment on HUT did not differ between men and women (P = 0.48) but did show a significant decrease by age group (P orthostatic intolerance by sex (P = 0.03) but not age (P = 0.58). There was no significant correlation between either symptoms of orthostatic intolerance and age [r = -0.13 (-0.31, 0.06), r(2) = 0.017; P = 0.17] or heart rate increment on HUT and symptoms of orthostatic intolerance [r = 0.15 (-0.04, 0.33), r(2) = 0.022; P = 0.13]. The results demonstrate that higher postural heart rate increments in younger individuals do not result in an increase in orthostatic intolerance. This highlights the potential need for a reevaluation of the diagnostic criteria for postural orthostatic tachycardia syndrome in younger individuals.

  1. SYSTEM RESEARCH OF YOUNGER TEENAGERS FROM POSITIONS OF A FLOOR AND A GENDER DEPENDING ON AGGRESSION OF BEHAVIOUR

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    Любовь Владимировна Мищенко

    2013-09-01

    Full Text Available Purpose: scientifically to prove aggression as the backbone factor of development of integrated individuality of younger teenagers and to define specificity of structures of integrated individuality of boys and girls of younger teenagers with high and low level of aggression.Methodology: the theoretical analysis of a problem of research in the psychological, pedagogical and methodical literature; ascertaining experiment; methods of mathematical and statistical data processing (t-criterion of Stjudenta, correlation and factorial analyses.Results:  on the basis of the teoretiko-empirical analysis we have come to the following - structures of integrated individuality of boys with aggressive behaviour are more harmonious, at them two full factors while at girls it is revealed - one full factor are revealed; however girls are more flexible - at them more облических communications; at boys leaders are socially - psychological properties, and at girls - temperament, carries out an organising role. Proceeding from results of research we have developed practical psihologo - pedagogical recommendations - ignoring of speech aggression; attention switching; a method of displaying of positive personal qualities and behavioural reactions; open verbal censure; belief; and certainly, humour and a joke.Practical implications: diagnostics and preventive maintenance of preventive maintenance of aggressive behaviour at boys and at girls of younger teenagers.DOI: http://dx.doi.org/10.12731/2218-7405-2013-6-30

  2. The Economic Burden of Vision Loss and Eye Disorders among the United States Population Younger than 40 Years

    Science.gov (United States)

    Wittenborn, John S.; Zhang, Xinzhi; Feagan, Charles W.; Crouse, Wesley L.; Shrestha, Sundar; Kemper, Alex R.; Hoerger, Thomas J.; Saaddine, Jinan B.

    2017-01-01

    Objective To estimate the economic burden of vision loss and eye disorders in the United States population younger than 40 years in 2012. Design Econometric and statistical analysis of survey, commercial claims, and census data. Participants The United States population younger than 40 years in 2012. Methods We categorized costs based on consensus guidelines. We estimated medical costs attributable to diagnosed eye-related disorders, undiagnosed vision loss, and medical vision aids using Medical Expenditure Panel Survey and MarketScan data. The prevalence of vision impairment and blindness were estimated using National Health and Nutrition Examination Survey data. We estimated costs from lost productivity using Survey of Income and Program Participation. We estimated costs of informal care, low vision aids, special education, school screening, government spending, and transfer payments based on published estimates and federal budgets. We estimated quality-adjusted life years (QALYs) lost based on published utility values. Main Outcome Measures Costs and QALYs lost in 2012. Results The economic burden of vision loss and eye disorders among the United States population younger than 40 years was $27.5 billion in 2012 (95% confidence interval, $21.5–$37.2 billion), including $5.9 billion for children and $21.6 billion for adults 18 to 39 years of age. Direct costs were $14.5 billion, including $7.3 billion in medical costs for diagnosed disorders, $4.9 billion in refraction correction, $0.5 billion in medical costs for undiagnosed vision loss, and $1.8 billion in other direct costs. Indirect costs were $13 billion, primarily because of $12.2 billion in productivity losses. In addition, vision loss cost society 215 000 QALYs. Conclusions We found a substantial burden resulting from vision loss and eye disorders in the United States population younger than 40 years, a population excluded from previous studies. Monetizing quality-of-life losses at $50 000 per QALY would

  3. ARIEL: an ESA M4 mission candidate

    Science.gov (United States)

    Puig, L.; Pilbratt, G. L.; Heske, A.; Escudero Sanz, I.; Crouzet, P.-E.

    2016-07-01

    The Atmospheric Remote sensing Infrared Exoplanet Large survey (ARIEL) mission is an M-class mission candidate within the science program Cosmic Vision of the European Space Agency (ESA). It was selected in June 2015 as one of three candidates to enter an assessment phase (phase 0/A). This process involves the definition of science and mission requirements as well as a preliminary model payload, and an internal Concurrent Design Facility (CDF) study providing the input to parallel industrial studies (in progress since 2016). After this process, the three candidates will be reviewed and in mid-2017 one of them will be selected as the M4 mission for launch in 2026. ARIEL is a survey-type mission dedicated to the characterisation of exoplanetary atmospheres. Using the differential technique of transit spectroscopy, ARIEL will obtain transmission and/or emission spectra of the atmospheres of a large and diverse sample of known exoplanets (~500) covering a wide range of masses, densities, equilibrium temperatures, orbital properties and host-star characteristics. This will include hot Jupiters to warm Super-Earths, orbiting M5 to F0 stars. This paper describes critical requirements, and reports on the results of the Concurrent Design Facility (CDF) study that was conducted in June / July 2015, providing a description of the resulting spacecraft design. It will employ a 0.7 m x 1.1 m off-axis three mirror telescope, feeding four photometric channels in the VNIR range (0.5-1.95 μm) and an IR spectrometer covering 1.95-7.8 μm.

  4. Blend Analysis of HATNet Transit Candidates

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    Bakos G.Á.

    2011-02-01

    Full Text Available Candidate transiting planet systems discovered by wide-field groundbased surveys must go through an intensive follow-up procedure to distinguish the true transiting planets from the much more common false positives. Especially pernicious are configurations of three or more stars which produce radial velocity and light curves that are similar to those of single stars transited by a planet. In this contribution we describe the methods used by the HATNet team to reject these blends, giving a few illustrative examples.

  5. Avalanche Effect in Improperly Initialized CAESAR Candidates

    Directory of Open Access Journals (Sweden)

    Martin Ukrop

    2016-12-01

    Full Text Available Cryptoprimitives rely on thorough theoretical background, but often lack basic usability features making them prone to unintentional misuse by developers. We argue that this is true even for the state-of-the-art designs. Analyzing 52 candidates of the current CAESAR competition has shown none of them have an avalanche effect in authentication tag strong enough to work properly when partially misconfigured. Although not directly decreasing their security profile, this hints at their security usability being less than perfect. Paper details available at crcs.cz/papers/memics2016

  6. Alcoholism and alternative splicing of candidate genes.

    Science.gov (United States)

    Sasabe, Toshikazu; Ishiura, Shoichi

    2010-04-01

    Gene expression studies have shown that expression patterns of several genes have changed during the development of alcoholism. Gene expression is regulated not only at the level of transcription but also through alternative splicing of pre-mRNA. In this review, we discuss some of the evidence suggesting that alternative splicing of candidate genes such as DRD2 (encoding dopamine D2 receptor) may form the basis of the mechanisms underlying the pathophysiology of alcoholism. These reports suggest that aberrant expression of splice variants affects alcohol sensitivities, and alcohol consumption also regulates alternative splicing. Thus, investigations of alternative splicing are essential for understanding the molecular events underlying the development of alcoholism.

  7. Microlensing Binaries with Candidate Brown Dwarf Companions

    DEFF Research Database (Denmark)

    Shin, I.-G; Han, C.; Gould, A.

    2012-01-01

    Brown dwarfs are important objects because they may provide a missing link between stars and planets, two populations that have dramatically different formation histories. In this paper, we present the candidate binaries with brown dwarf companions that are found by analyzing binary microlensing...... masses of the brown dwarf companions are 0.02 ± 0.01 M⊙ and 0.019 ± 0.002 M⊙ for MOA-2011-BLG-104/OGLE-2011-BLG-0172 and MOA-2011-BLG-149, respectively, and both companions are orbiting low-mass M dwarf host stars. More microlensing brown dwarfs are expected to be detected as the number of lensing events...

  8. Reducing stigma and discrimination: Candidate interventions

    Directory of Open Access Journals (Sweden)

    Kassam Aliya

    2008-04-01

    Full Text Available Abstract This paper proposes that stigma in relation to people with mental illness can be understood as a combination of problems of knowledge (ignorance, attitudes (prejudice and behaviour (discrimination. From a literature review, a series of candidate interventions are identified which may be effective in reducing stigmatisation and discrimination at the following levels: individuals with mental illness and their family members; the workplace; and local, national and international. The strongest evidence for effective interventions at present is for (i direct social contact with people with mental illness at the individual level, and (ii social marketing at the population level.

  9. Geoscience Training for NASA Astronaut Candidates

    Science.gov (United States)

    Young, K. E.; Evans, C. A.; Bleacher, J. E.; Graff, T. G.; Zeigler, R.

    2017-01-01

    After being selected to the astronaut office, crewmembers go through an initial two year training flow, astronaut candidacy, where they learn the basic skills necessary for spaceflight. While the bulk of astronaut candidate training currently centers on the multiple subjects required for ISS operations (EVA skills, Russian language, ISS systems, etc.), training also includes geoscience training designed to train crewmembers in Earth observations, teach astronauts about other planetary systems, and provide field training designed to investigate field operations and boost team skills. This training goes back to Apollo training and has evolved to support ISS operations and future exploration missions.

  10. Top Zika Vaccine Candidate Moves Closer to Field Testing

    Science.gov (United States)

    ... https://medlineplus.gov/news/fullstory_161274.html Top Zika Vaccine Candidate Moves Closer to Field Testing DNA- ... MONDAY, Oct. 3, 2016 (HealthDay News) -- The leading Zika vaccine candidate should be ready for field testing ...

  11. Phenol sulfotransferases: Candidate genes for Batten disease

    Energy Technology Data Exchange (ETDEWEB)

    Dooley, T.P.; Probst, P.; Obermoeller, R.D. [M.D. Anderson Cancer Center, Houston, TX (United States)] [and others

    1995-06-05

    Batten disease (juvenile-onset neuronal ceroid lipofuscinosis; JNCL) is an autosomal recessive neurodegenerative disorder, characterized by the cytosomal accumulation of autofluorescent protolipopigments in neurons and other cell types. The Batten disease gene (CLN3) has not yet been identified, but has been mapped to a small region of human chromosome area 16p12.1-p11.2. We recently reported the fortuitous discovery that the cytosolic phenol sulfotransferase gene (STP) is located within this same interval of chromosome 16p. Since phenol sulfotransferase is expressed in neurons, can sulfate lipophilic phenolic compounds, and is mapped near CLN3, STP is considered as a candidate gene for Batten disease. YAC and cosmid cloning results have further substantiated the close proximity of STP and a highly related sulfotransferase (STM), encoding the catecholamine-preferring enzyme, to the CLN3 region of chromosome 16p. In this report, we summarize some of the recent progress in the identification of two phenol sulfotransferase genes (STP and STM) as positional candidate genes for Batten disease. 42 refs., 1 tab.

  12. Pulsar Candidates Toward Fermi Unassociated Sources

    CERN Document Server

    Frail, D A; Jagannathan, P; Intema, H T

    2016-01-01

    We report on a search for steep spectrum radio sources within the 95% confidence error ellipses of the Fermi unassociated sources from the Large Array Telescope (LAT). Using existing catalogs and the newly released GMRT all-sky survey at 150 MHz we identify compact radio sources that are bright at MHz frequencies but faint or absent at GHz frequencies. Such steep spectrum radio sources are rare and constitute a sample of pulsar candidates, selected independently of period, dispersion measure, interstellar scattering and orbital parameters. We find point-like, steep spectrum candidates toward 11 Fermi sources. Based on the gamma-ray/radio positional coincidence, the rarity of such radio sources, and the properties of the 3FGL sources themselves, we argue that many of these sources could be pulsars. They may have been missed by previous radio periodicity searches due to interstellar propagation effects or because they lie in an unusually tight binary. If this hypothesis is correct, then renewed gamma-ray and ra...

  13. Nonclinical Development of BCG Replacement Vaccine Candidates

    Directory of Open Access Journals (Sweden)

    Bernd Eisele

    2013-04-01

    Full Text Available The failure of current Mycobacterium bovis bacille Calmette–Guérin (BCG vaccines, given to neonates to protect against adult tuberculosis and the risk of using these live vaccines in HIV-infected infants, has emphasized the need for generating new, more efficacious and safer replacement vaccines. With the availability of genetic techniques for constructing recombinant BCG (rBCG strains containing well-defined gene deletions or insertions, new vaccine candidates are under evaluation at both the preclinical and clinical stages of development. Since most BCG vaccines in use today were evaluated in clinical trials decades ago and are produced by outdated processes, the development of new BCG vaccines offers a number of advantages that include a modern well-defined manufacturing process along with state-of-the-art evaluation of safety and efficacy in target populations. We provide a description of the preclinical development of two novel rBCGs, VPM1002 that was constructed by adding a modified hly gene coding for the protein listeriolysin O (LLO from Listeria monocytogenes and AERAS-422, which carries a modified pfoA gene coding for the protein perfringolysin O (PFO from Clostridium perfringens, and three genes from Mycobacterium tuberculosis. Novel approaches like these should be helpful in generating stable and effective rBCG vaccine candidates that can be better characterized than traditional BCG vaccines.

  14. Theoretical Comparison Between Candidates for Dark Matter

    Science.gov (United States)

    McKeough, James; Hira, Ajit; Valdez, Alexandra

    2017-01-01

    Since the generally-accepted view among astrophysicists is that the matter component of the universe is mostly dark matter, the search for dark matter particles continues unabated. The Large Underground Xenon (LUX) improvements, aided by advanced computer simulations at the U.S. Department of Energy's Lawrence Berkeley National Laboratory's (Berkeley Lab) National Energy Research Scientific Computing Center (NERSC) and Brown University's Center for Computation and Visualization (CCV), can potentially eliminate some particle models of dark matter. Generally, the proposed candidates can be put in three categories: baryonic dark matter, hot dark matter, and cold dark matter. The Lightest Supersymmetric Particle(LSP) of supersymmetric models is a dark matter candidate, and is classified as a Weakly Interacting Massive Particle (WIMP). Similar to the cosmic microwave background radiation left over from the Big Bang, there is a background of low-energy neutrinos in our Universe. According to some researchers, these may be the explanation for the dark matter. One advantage of the Neutrino Model is that they are known to exist. Dark matter made from neutrinos is termed ``hot dark matter''. We formulate a novel empirical function for the average density profile of cosmic voids, identified via the watershed technique in ΛCDM N-body simulations. This function adequately treats both void size and redshift, and describes the scale radius and the central density of voids. We started with a five-parameter model. Our research is mainly on LSP and Neutrino models.

  15. Vaccine candidates for leishmaniasis: a review.

    Science.gov (United States)

    Nagill, Rajeev; Kaur, Sukhbir

    2011-10-01

    Leishmaniasis is a diverse group of clinical syndromes caused by protozoan parasites of the genus Leishmania. The clinical manifestation of the disease varies from self-limiting cutaneous lesions to progressive visceral disease. It is estimated that 350 million people are at risk in 88 countries, with a global incidence of 1-1.5 million cases of cutaneous and 500,000 cases of visceral leishmaniasis. The key control measures mainly rely on early case detection and chemotherapy which has been hampered by the toxicity of drugs, side-effects and by the emergence of drug resistance in parasites. Control of reservoir host and vector is difficult due to operational difficulties and frequent relapses in the host. Therefore, the development of effective and affordable vaccine against leishmaniasis is highly desirable. Although considerable progress has been made over the last decade in understanding immune mechanisms underlying potential candidate antigens, including killed, live attenuated parasites, crude parasites, pure or recombinant Leishmania proteins or DNA encoding leishmanial proteins, as well as immunomodulators from sand fly saliva, very few candidate vaccines have progressed beyond the experimental stage. As such there is no vaccine against any form of human leishmaniasis. In recent years, however, much interest has been stimulated towards vaccination against leishmaniasis focused mainly on cutaneous leishmaniasis with fewer attempts against visceral leishmaniasis.

  16. Serological profile of candidates for corneal donation

    Directory of Open Access Journals (Sweden)

    Adroaldo Lunardelli

    2014-10-01

    Full Text Available Objetive: The purpose of this study is to map the serological profile of candidates to corneal donation at Irmandade Santa Casa de Misericórdia de Porto Alegre, identifying the percentage of disposal by serology and the marker involved. Methods: There have been analised – retrospectively – the results of serology of all corneal donors, made between the period of 1st january 2006 and 31st december 2012. Data analised were related to age, gender and the results of serology pertinent to viral markers (HBsAg, anti-HBc, anti-HCV and anti-HIV, these, determined by immunosorbent tests (ELISA. Results: In the period of the study, there were 2476 corneal donors at the institution, with a major incidence on the male gender, on an average of 58.7 years old. 23% of retention because of serological unfitness was also identified, that is, 570 samples were non-negative to any of the used tests. The marker anti- HBc was the most prevalent on the studied population, followed by the Hepatitis C virus (HCV and by the Human Immunodeficiency Virus (HIV. Conclusion: From the data found through this study, it is essential to have the participation of an efficient service on the serological evaluation of the candidates to corneal donation, once the security of the receptor must be taken into consideration in a population of donors with 23% of unfitness prevalence, in which the most prevalent marker is the one of Hepatits B.

  17. Elemental Abundances of Solar Sibling Candidates

    Science.gov (United States)

    Ramírez, I.; Bajkova, A. T.; Bobylev, V. V.; Roederer, I. U.; Lambert, D. L.; Endl, M.; Cochran, W. D.; MacQueen, P. J.; Wittenmyer, R. A.

    2014-06-01

    Dynamical information along with survey data on metallicity and in some cases age have been used recently by some authors to search for candidates of stars that were born in the cluster where the Sun formed. We have acquired high-resolution, high signal-to-noise ratio spectra for 30 of these objects to determine, using detailed elemental abundance analysis, if they could be true solar siblings. Only two of the candidates are found to have solar chemical composition. Updated modeling of the stars' past orbits in a realistic Galactic potential reveals that one of them, HD 162826, satisfies both chemical and dynamical conditions for being a sibling of the Sun. Measurements of rare-element abundances for this star further confirm its solar composition, with the only possible exception of Sm. Analysis of long-term high-precision radial velocity data rules out the presence of hot Jupiters and confirms that this star is not in a binary system. We find that chemical tagging does not necessarily benefit from studying as many elements as possible but instead from identifying and carefully measuring the abundances of those elements that show large star-to-star scatter at a given metallicity. Future searches employing data products from ongoing massive astrometric and spectroscopic surveys can be optimized by acknowledging this fact.

  18. Elemental Abundances of Solar Sibling Candidates

    CERN Document Server

    Ramirez, I; Bobylev, V V; Roederer, I U; Lambert, D L; Endl, M; Cochran, W D; MacQueen, P J; Wittenmyer, R A

    2014-01-01

    Dynamical information along with survey data on metallicity and in some cases age have been used recently by some authors to search for candidates of stars that were born in the cluster where the Sun formed. We have acquired high resolution, high signal-to-noise ratio spectra for 30 of these objects to determine, using detailed elemental abundance analysis, if they could be true solar siblings. Only two of the candidates are found to have solar chemical composition. Updated modeling of the stars' past orbits in a realistic Galactic potential reveals that one of them, HD162826, satisfies both chemical and dynamical conditions for being a sibling of the Sun. Measurements of rare-element abundances for this star further confirm its solar composition, with the only possible exception of Sm. Analysis of long-term high-precision radial velocity data rules out the presence of hot Jupiters and confirms that this star is not in a binary system. We find that chemical tagging does not necessarily benefit from studying a...

  19. Advanced Vaccine Candidates for Lassa Fever

    Directory of Open Access Journals (Sweden)

    Igor S. Lukashevich

    2012-10-01

    Full Text Available Lassa virus (LASV is the most prominent human pathogen of the Arenaviridae. The virus is transmitted to humans by a rodent reservoir, Mastomys natalensis, and is capable of causing lethal Lassa Fever (LF. LASV has the highest human impact of any of the viral hemorrhagic fevers (with the exception of Dengue Fever with an estimated several hundred thousand infections annually, resulting in thousands of deaths in Western Africa. The sizeable disease burden, numerous imported cases of LF in non-endemic countries, and the possibility that LASV can be used as an agent of biological warfare make a strong case for vaccine development. Presently there is no licensed vaccine against LF or approved treatment. Recently, several promising vaccine candidates have been developed which can potentially target different groups at risk. The purpose of this manuscript is to review the LASV pathogenesis and immune mechanisms involved in protection. The current status of pre-clinical development of the advanced vaccine candidates that have been tested in non-human primates will be discussed. Major scientific, manufacturing, and regulatory challenges will also be considered.

  20. Advanced vaccine candidates for Lassa fever.

    Science.gov (United States)

    Lukashevich, Igor S

    2012-10-29

    Lassa virus (LASV) is the most prominent human pathogen of the Arenaviridae. The virus is transmitted to humans by a rodent reservoir, Mastomys natalensis, and is capable of causing lethal Lassa Fever (LF). LASV has the highest human impact of any of the viral hemorrhagic fevers (with the exception of Dengue Fever) with an estimated several hundred thousand infections annually, resulting in thousands of deaths in Western Africa. The sizeable disease burden, numerous imported cases of LF in non-endemic countries, and the possibility that LASV can be used as an agent of biological warfare make a strong case for vaccine development. Presently there is no licensed vaccine against LF or approved treatment. Recently, several promising vaccine candidates have been developed which can potentially target different groups at risk. The purpose of this manuscript is to review the LASV pathogenesis and immune mechanisms involved in protection. The current status of pre-clinical development of the advanced vaccine candidates that have been tested in non-human primates will be discussed. Major scientific, manufacturing, and regulatory challenges will also be considered.

  1. Uncovering the nucleus candidate for NGC 253

    CERN Document Server

    Günthardt, G I; Camperi, J A; Díaz, R J; Gomez, P L; Bosch, G; Schirmer, M

    2015-01-01

    NGC253 is the nearest spiral galaxy with a nuclear starburst which becomes the best candidate to study the relationship between starburst and AGN activity. However, this central region is veiled by large amounts of dust, and it has been so far unclear which is the true dynamical nucleus. The near infrared spectroscopy could be advantageous in order to shed light on the true nucleus identity. Using Flamingos-2 at Gemini South we have taken deep K-band spectra along the major axis and through the brightest infrared source. We present evidence showing that the brightest near infrared and mid infrared source in the central region, already known as radio source TH7 and so far considered just a stellar supercluster, in fact, presents various symptoms of a genuine galactic nucleus. Therefore, it should be considered a valid nucleus candidate. It is the most massive compact infrared object in the central region, located at 2.0" of the symmetry center of the galactic bar. Moreover, our data indicate that this object i...

  2. Elemental abundances of solar sibling candidates

    Energy Technology Data Exchange (ETDEWEB)

    Ramírez, I.; Lambert, D. L.; Endl, M.; Cochran, W. D.; MacQueen, P. J. [McDonald Observatory and Department of Astronomy, University of Texas at Austin, 2515 Speedway, Stop C1400, Austin, Texas 78712-1205 (United States); Bajkova, A. T.; Bobylev, V. V. [Central (Pulkovo) Astronomical Observatory of RAS, 65/1, Pulkovskoye Chaussee, St. Petersburg 196140 (Russian Federation); Roederer, I. U. [Department of Astronomy, University of Michigan, 500 Church Street, Ann Arbor, MI 48109 (United States); Wittenmyer, R. A. [School of Physics, UNSW Australia, Sydney 2052 (Australia)

    2014-06-01

    Dynamical information along with survey data on metallicity and in some cases age have been used recently by some authors to search for candidates of stars that were born in the cluster where the Sun formed. We have acquired high-resolution, high signal-to-noise ratio spectra for 30 of these objects to determine, using detailed elemental abundance analysis, if they could be true solar siblings. Only two of the candidates are found to have solar chemical composition. Updated modeling of the stars' past orbits in a realistic Galactic potential reveals that one of them, HD 162826, satisfies both chemical and dynamical conditions for being a sibling of the Sun. Measurements of rare-element abundances for this star further confirm its solar composition, with the only possible exception of Sm. Analysis of long-term high-precision radial velocity data rules out the presence of hot Jupiters and confirms that this star is not in a binary system. We find that chemical tagging does not necessarily benefit from studying as many elements as possible but instead from identifying and carefully measuring the abundances of those elements that show large star-to-star scatter at a given metallicity. Future searches employing data products from ongoing massive astrometric and spectroscopic surveys can be optimized by acknowledging this fact.

  3. Political Candidate Campaign Advertising: A Selected Review of the Literature.

    Science.gov (United States)

    Hellweg, Susan A.

    This paper provides a selected review of political candidate campaign advertising studies from the political science, mass communication, advertising, and political communication literature. The paper examines the literature in terms of research pertaining to (1) candidate advertising content (commercials for male versus female candidates and for…

  4. Views on Values Education: From Teacher Candidates to Experienced Teachers

    Science.gov (United States)

    Iscan, Canay Demirhan

    2015-01-01

    This study aimed to identify the views of experienced class teachers and class teacher candidates on values education. It conducted standard open-ended interviews with experienced class teachers and teacher candidates. The study group comprised 9 experienced class teachers from different socio-economic levels and 9 teacher candidates with…

  5. Encouraging Discussion between Teacher Candidates and Families with Exceptional Children

    Science.gov (United States)

    Williams, Emily

    2012-01-01

    The Families as Faculty experience assists universities to better prepare candidates for service as classroom teachers. Upon entering their practica and student teaching, many teacher candidates have had no to limited contact with exceptional students. Often candidates are unaware of the realities of having a student with disabilities in their…

  6. Mirror Images: Teacher Candidates' Perceptions of Disposition Development

    Science.gov (United States)

    Bercaw, Lynne A.; Summers, Deborah G.; Colby, Susan A.; Payne, Maggie

    2012-01-01

    The complexity of disposition development for teacher candidates continues to be discussed and debated in teacher education. This study compares two programs and the different ways each approaches the disposition development of their respective candidates. More than 200 candidates from two institutions were surveyed on how and where they perceived…

  7. Identity Functions and Empathetic Tendencies of Teacher Candidates

    Science.gov (United States)

    Ay, Alpaslan; Kadi, Aysegul

    2016-01-01

    Objective of this research is to investigate identity functions and empathetic tendencies of teacher candidates. Sample consists of 232 teacher candidates in social studies teacher education. Survey model is preferred to investigate the difference between identity functions and empathetic tendencies of teacher candidates. And also correlational…

  8. Production of EV71 vaccine candidates.

    Science.gov (United States)

    Chong, Pele; Hsieh, Shih-Yang; Liu, Chia-Chyi; Chou, Ai-Hsiang; Chang, Jui-Yuan; Wu, Suh-Chin; Liu, Shih-Jen; Chow, Yen-Hung; Su, Ih-Jen; Klein, Michel

    2012-12-01

    Enterovirus 71 (EV71) is now recognized as an emerging neurotropic virus in Asia and with Coxsackie virus (CV) it is the other major causative agent of hand-foot-mouth diseases (HFMD). Effective medications and/or prophylactic vaccines against HFMD are urgently needed. From a scientific (the feasibility of bioprocess, immunological responses and potency in animal challenge model) and business development (cost of goods) points of view, we in this review address and discuss the pros and cons of different EV71 vaccine candidates that have been produced and evaluated in animal models. Epitope-based synthetic peptide vaccine candidates containing residues 211-225 of VP1 formulated with Freund's adjuvant (CFA/IFA) elicited low EV71 virus neutralizing antibody responses, but were protective in the suckling mouse challenge model. Among recombinant EV71 subunits (rVP1, rVP2 and rVP3) expressed in E. coli, purified and formulated with CFA/IFA, only VP1 elicited mouse antibody responses with measurable EV71-specific virus neutralization titers. Immunization of mice with either a DNA plasmid containing VP1 gene or VP1 expressed in Salmonella typhimurium also generated neutralizing antibody responses and protected animals against a live EV71 challenge. Recombinant EV71 virus-like particles (rVLP) produced from baculovirus formulated either with CFA/IFA or alum elicited good virus neutralization titers in both mice and non-human primates, and were found to be protective in the suckling mouse EV71 challenge model. Synthetic peptides or recombinant EV71 subunit vaccines (rVP1 and rVLP) formulated in alum were found to be poorly immunogenic in rabbits. Only formalin-inactivated (FI) EV71 virions formulated in alum elicited cross-neutralizing antibodies against different EV71 genotypes in mice, rabbits and non-human primates but induced weak neutralizing responses against CAV16. From a regulatory, economic and market acceptability standpoint, FI-EV71 virion vaccines are the most

  9. A direct molecular link between the autism candidate gene RORa and the schizophrenia candidate MIR137

    Science.gov (United States)

    Devanna, Paolo; Vernes, Sonja C.

    2014-02-01

    Retinoic acid-related orphan receptor alpha gene (RORa) and the microRNA MIR137 have both recently been identified as novel candidate genes for neuropsychiatric disorders. RORa encodes a ligand-dependent orphan nuclear receptor that acts as a transcriptional regulator and miR-137 is a brain enriched small non-coding RNA that interacts with gene transcripts to control protein levels. Given the mounting evidence for RORa in autism spectrum disorders (ASD) and MIR137 in schizophrenia and ASD, we investigated if there was a functional biological relationship between these two genes. Herein, we demonstrate that miR-137 targets the 3'UTR of RORa in a site specific manner. We also provide further support for MIR137 as an autism candidate by showing that a large number of previously implicated autism genes are also putatively targeted by miR-137. This work supports the role of MIR137 as an ASD candidate and demonstrates a direct biological link between these previously unrelated autism candidate genes.

  10. Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age

    Directory of Open Access Journals (Sweden)

    Farooqi Haumith K

    2008-10-01

    Full Text Available Abstract Background Glioblastomas are the most common primary brain tumour in adults. While the prognosis for patients is poor, gene expression profiling has detected signatures that can sub-classify GBMs relative to histopathology and clinical variables. One category of GBM defined by a gene expression signature is termed ProNeural (PN, and has substantially longer patient survival relative to other gene expression-based subtypes of GBMs. Age of onset is a major predictor of the length of patient survival where younger patients survive longer than older patients. The reason for this survival advantage has not been clear. Methods We collected 267 GBM CEL files and normalized them relative to other microarrays of the same Affymetrix platform. 377 probesets on U133A and U133 Plus 2.0 arrays were used in a gene voting strategy with 177 probesets of matching genes on older U95Av2 arrays. Kaplan-Meier curves and Cox proportional hazard analyses were applied in distinguishing survival differences between expression subtypes and age. Results This meta-analysis of published data in addition to new data confirms the existence of four distinct GBM expression-signatures. Further, patients with PN subtype GBMs had longer survival, as expected. However, the age of the patient at diagnosis is not predictive of survival time when controlled for the PN subtype. Conclusion The survival benefit of younger age is nullified when patients are stratified by gene expression group. Thus, the main cause of the age effect in GBMs is the more frequent occurrence of PN GBMs in younger patients relative to older patients.

  11. Impact of negative emotion on the neural correlates of long-term recognition in younger and older adults

    Directory of Open Access Journals (Sweden)

    Grégoria eKalpouzos

    2012-09-01

    Full Text Available Some studies have suggested that the memory advantage for negative emotional information over neutral information (negativity effect is reduced in aging. Besides the fact that most findings are based on immediate retrieval, the neural underpinnings of long-term emotional memory in aging have so far not been investigated. To address these issues, we assessed recognition of neutral and negative scenes after one- and 3-week retention intervals in younger and older adults using fMRI. We further used an event-related design in order to disentangle successful, false and true recognition. This study revealed 4 key findings: 1 Increased retention interval induced an increased rate of false recognitions for negative scenes, cancelling out the negativity effect (present for hit rates only on discrimination in both younger and older adults; 2 In younger, but not older, adults, reduced activity of the medial temporal lobe was observed over time for neutral scenes, but not for negative scenes, where stable or increased activity was seen; 3 Engagement of amygdala was observed in older adults after a 3-week delay during successful recognition of negative scenes (hits versus misses in comparison with neutral scenes, which may indicate engagement of automatic processes, but engagement of ventrolateral prefrontal cortex was unrelated to amygdala activity and performance; and 4 After 3 weeks, but not after one week, true recognition of negative scenes was characterized by more activity in left hippocampus and lateral occipito-temporal regions (hits versus false alarms. As these regions are known to be related to consolidation mechanisms, the observed pattern may indicate the presence of delayed consolidation of true memories. Nonetheless, older adults’ low performance in discrimination of negative scenes could reflect the fact that overall, after long delays of retention, they rely more on general information rather than on perceptual detail in making

  12. 牛津小学英语6B Unit 1 who is younger?教学设计

    Institute of Scientific and Technical Information of China (English)

    朱海平

    2010-01-01

    @@ 1教学内容 牛津小学英语6B.Unitl whois younger?A Listen,read and say.P6 2教学目标 2.1 初步掌握理解句型,并能在交际中口头运用比较级句型 2.2掌握四会单词和词组go for a walk,cousin,have a chat,as…as…,twin sister,look the same,want to meet sb.

  13. Coarse and fine N1 tuning for print in younger and older Chinese children: Orthography, phonology, or semantics driven?

    Science.gov (United States)

    Tong, Xiuhong; Lo, Jason Chor Ming; McBride, Catherine; Ho, Connie Suk-Han; Waye, Mary Miu Yee; Chung, Kevin Kien Hoa; Wong, Simpson Wai Lap; Chow, Bonnie Wing-Yin

    2016-10-01

    Visual expertise in distinguishing words from objects and word-like stimuli is a fundamental skill that is important for children to become proficient readers. This expertise can be indexed by the N1 component of ERPs at the neural level. However, the nature of N1 tuning for print is controversial in terms of onset of the latency, lateralization and the neural mechanism of the N1. This study aimed to investigate whether two groups of Chinese children could discriminate characters/character-like stimuli from visual controls (i.e., coarse N1 tuning) and distinguish characters from character-like stimuli (i.e., fine N1 tuning). We also explored the cognitive-linguistic correlates of N1 tuning. Seventeen children in the younger group (M=7.7 years) and 13 in the older group (M=9.4 years) were all required to finish a character decision task with character, pseudocharacter, noncharacter, and stroke combination conditions using ERP testing. Both the pseudocharacters and noncharacters were unpronounceable, and the main difference between the two conditions was in orthographic presentation (i.e., radical position). Children were also administered measures of reading fluency, reading accuracy, RAN, phonological skill and vocabulary knowledge. ERP results showed that a significantly larger N1 was observed in the characters, pseudocharacters, and noncharacters as compared to the stroke combinations in both groups. The N1 for characters and pseudocharacters was also significantly larger than that for noncharacters in both groups. Both coarse and fine N1s were larger for younger children than for older children, and the N1 was bilateral in younger children, but left lateralized in older children. Correlational analyses showed that the coarse N1 tuning of real characters versus visual controls was moderately correlated with reading fluency and accuracy but not RAN, phonology, or vocabulary. Taken together, our study suggests that both coarse and fine N1 tuning occurs in both

  14. ELECTIONS PENSION FUND CANDIDATE NR 4

    CERN Document Server

    2001-01-01

    ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate : Name : MYERS First Name : Stephen I have been at CERN since 1972, and was elected member of the Governing Board for the first time in 1998. The Governing Board then nominated me to the Investments Committee where I have been a member since the beginning of 1999. Since then I have actively participated in redefining and transforming the investment portfolio in order to improve the overall return and where possible reduce the risk. The portfolio has recently been greatly improved and now allows much simpler more transparent monitoring of our investment. I have also actively participated and hopefully made useful contributions in discussions conc...

  15. ELECTIONS PENSION FUND 4th candidate

    CERN Multimedia

    2001-01-01

    ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate : Name : MYERS First Name : Stephen I have been at CERN since 1972, and was elected member of the Governing Board for the first time in 1998. The Governing Board then nominated me to the Investments Committee where I have been a member since the beginning of 1999. Since then I have actively participated in redefining and transforming the investment portfolio in order to improve the overall return and where possible reduce the risk. The portfolio has recently been greatly improved and now allows much simpler more transparent monitoring of our investment. I have also actively participated and hopefully made useful contributions in discussions conc...

  16. Alcoholism and Alternative Splicing of Candidate Genes

    Directory of Open Access Journals (Sweden)

    Toshikazu Sasabe

    2010-03-01

    Full Text Available Gene expression studies have shown that expression patterns of several genes have changed during the development of alcoholism. Gene expression is regulated not only at the level of transcription but also through alternative splicing of pre-mRNA. In this review, we discuss some of the evidence suggesting that alternative splicing of candidate genes such as DRD2 (encoding dopamine D2 receptor may form the basis of the mechanisms underlying the pathophysiology of alcoholism. These reports suggest that aberrant expression of splice variants affects alcohol sensitivities, and alcohol consumption also regulates alternative splicing. Thus, investigations of alternative splicing are essential for understanding the molecular events underlying the development of alcoholism.

  17. Halopentacenes: Promising Candidates for Organic Semiconductors

    Institute of Scientific and Technical Information of China (English)

    DU Gong-He; REN Zhao-Yu; GUO Ping; ZHENG Ji-Ming

    2009-01-01

    We introduce polar substituents such as F, Cl, Br into pentacene to enhance the dissolubility in common organic solvents while retaining the high charge-carrier mobilities of pentacene. Geometric structures, dipole moments,frontier molecule orbits, ionization potentials and electron affinities, as well as reorganization energies of those molecules, and of pentacene for comparison, are successively calculated by density functional theory. The results indicate that halopentacenes have rather small reorganization energies (< 0.2 eV), and when the substituents are in position 2 or positions 2 and 9, they are polarity molecules. Thus we conjecture that they can easily be dissolved in common organic solvents, and are promising candidates for organic semiconductors.

  18. ELECTIONS PENSION FUND CANDIDATE NR 3

    CERN Multimedia

    2001-01-01

    ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate : Name : HAUVILLER First Name : Claude Dear colleague of CERN and ESO, For the first time, I am standing and requesting your support to become a member of the Governing Board of our Pension Fund. CERN staff member since 1974, I have already carried elective mandates: I have been Delegate to the Staff Council and Member of the Senior Staff Consultative Committee (the Nine). For the majority of us, our Pension Fund is our only social provident scheme and source of retirement income; I believe I can usefully contribute to its successful management and help ensure its balance. Our Fund reaches its majority: soon, there will be more beneficiaries tha...

  19. ELECTIONS PENSION FUND 3rd candidate

    CERN Multimedia

    2001-01-01

    ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate : Name : Hauviller First Name : Claude Dear colleague of CERN and ESO, For the first time, I am standing and requesting your support to become a member of the Governing Board of our Pension Fund. CERN staff member since 1974, I have already carried elective mandates: I have been Delegate to the Staff Council and Member of the Senior Staff Consultative Committee (the Nine). For the majority of us, our Pension Fund is our only social provident scheme and source of retirement income; I believe I can usefully contribute to its successful management and help ensure its balance. Our Fund reaches its majority: soon, there will be more beneficiaries tha...

  20. New potential AChE inhibitor candidates.

    Science.gov (United States)

    de Paula, A A N; Martins, J B L; dos Santos, M L; Nascente, L de C; Romeiro, L A S; Areas, T F M A; Vieira, K S T; Gambôa, N F; Castro, N G; Gargano, R

    2009-09-01

    We have theoretically studied new potential candidates of acetylcholinesterase (AChE) inhibitors designed from cardanol, a non-isoprenoid phenolic lipid of cashew Anacardium occidentale nut-shell liquid. The electronic structure calculations of fifteen molecule derivatives from cardanol were performed using B3LYP level with 6-31G, 6-31G(d), and 6-311+G(2d,p) basis functions. For this study we used the following groups: methyl, acetyl, N,N-dimethylcarbamoyl, N,N-dimethylamine, N,N-diethylamine, piperidine, pyrrolidine, and N,N-methylbenzylamine. Among the proposed compounds we identified that the structures with substitution by N,N-dimethycarbamoyl, N,N-dimethylamine, and pyrrolidine groups were better correlated to rivastigmine, and represent possible AChE inhibitors against Alzheimer disease.

  1. Hypervelocity Star Candidates in the SEGUE G & K Dwarf Sample

    CERN Document Server

    Palladino, Lauren E; Holley-Bockelmann, Kelly; Prieto, Carlos Allende; Beers, Timothy C; Lee, Young Sun; Schneider, Donald P

    2013-01-01

    We identify 13 candidate hypervelocity stars from the Sloan Extension for Galactic Understanding and Exploration (SEGUE) G and K dwarf samples. Previous searches for hypervelocity stars have only focused on large radial velocities; in this study we also use proper motions to select the candidates. We determine the hypervelocity likelihood of each candidate, considering the significant errors often associated with high proper motion stars via Monte Carlo simulations. We find that more than half of the candidates exceed their escape velocities with at least 90% probability. All of our candidates also have less than a 60% chance of being a high velocity fluke within the SEGUE sample. Based on orbits calculated using the observed 6-d positions and velocities, few, if any, of these candidates originate from the Galactic Center. If these candidates are truly hypervelocity stars, they were not ejected by interactions with the Milky Way's supermassive black hole. This calls for a more serious examination of alternati...

  2. Animalistic Dehumanization of Older People by Younger Ones: Variations of Humanness Perceptions as a Function of a Target's Age.

    Science.gov (United States)

    Boudjemadi, Valérian; Demoulin, Stéphanie; Bastart, Jennifer

    2017-02-23

    The present work investigated associations of older people with humanness. Focusing on complementary approaches (attribute-based, metaphor-based, and target-based), 4 studies tested the hypothesis that older people are the targets of animalistic dehumanization. Using an emotional attribution task, Study 1 (N = 112) explored infrahumanization and shows that young participants attributed more uniquely human emotions to young people than to older ones. No such effect occurred with regards to nonuniquely human emotions. Results of Study 2 (N = 62) replicated this result using a lexical-decision task. Using the metaphor-based approach, Study 3 (N = 99) confirmed that older people's dehumanization is restricted to its animalistic form and does not extend to the mechanistic one. Finally, in Study 4 (N = 167), we used a target-based approach and showed that characteristics initially attributed to older people are perceived as denoting lesser humanness than when these same characteristics are associated with younger people. Results of the 4 studies provide evidence for an animalistic form of dehumanization of older people by younger ones. Limits, implications, and future research are discussed. (PsycINFO Database Record

  3. Actigraphy correctly predicts sleep behavior in infants who are younger than six months, when compared with polysomnography.

    Science.gov (United States)

    So, Kevin; Buckley, Pat; Adamson, T Michael; Horne, Rosemary S C

    2005-10-01

    Actigraphy has been widely used in adults and children. In infants, validation of actigraphy has typically used a comparison with behaviorally determined sleep state classification rather than polysomnography (PSG). This study validated actigraphy against PSG for determining sleep and waking states in infants who were younger than 6 mo. Twenty-two healthy infants, 13 term and 9 preterm, were studied at three different matched postconceptional ages. Actigraph data were compared with PSG recordings in 1-min epochs. Agreement rate (AR), predictive value for sleep, predictive value for wake, sensitivity. and specificity were calculated and compared between activity thresholds and across ages with two-way ANOVA for repeated measures. Thirty-two validation studies were analyzed. Overall AR with PSG of 93.7 +/- 1.3 and 91.6 +/- 1.8 were obtained at 2-4 wk and 5-6 mo, respectively, at the low activity threshold setting, whereas the auto activity threshold gave the best agreement with PSG at 2-4 mo (AR 89.3 +/- 1.3%). Sensitivity values of 96.2 +/- 1.1% at 2-4 wk, 91.2 +/- 1.5% at 2-4 mo, and 94.0 +/- 1.9% were obtained at these same settings. There was no difference across ages in AR or sensitivity. PVW and specificity values were low in this study. We conclude that actigraphy is a valid method for monitoring sleep in infants who are younger than 6 mo.

  4. Focused and divided attention in a simulated cocktail-party situation: ERP evidence from younger and older adults.

    Science.gov (United States)

    Getzmann, Stephan; Golob, Edward J; Wascher, Edmund

    2016-05-01

    Speech perception under complex listening conditions usually decreases in aging. This is especially true for listening conditions requiring divided attention among 2 and more relevant speakers. Using a speech perception task and event-related potential measures, we studied the ability of younger and older adults to attend to speech information from a single-target speaker (focused attention) or from 2 different (alternative) target speakers (divided attention). The focused and divided attention conditions were presented either in silence or in the presence of 3 concurrent speakers. In the presence of concurrent speakers, older participants showed worse performance with divided versus focused attention. In contrast, there was no effect of attention condition for the younger adults. Relative to the young, event-related potential analysis in older subjects indicated a decline in preparatory activity for the critical speech information (a delayed and smaller contingent negative variation), and delayed attentional control (indicated by a longer P2 latency). Standardized low-resolution brain electromagnetic tomography revealed that the age-related decline in preparatory activity was associated with reduced activation of medial and superior frontal gyrus and anterior cingulate gyrus. The results suggest that age-related differences in these prefrontal brain areas reflect declines in preparatory attention and gating of subsequent task-related speech information, especially under conditions of divided attention. These findings may reflect mechanisms relating to impaired speech perception by older people in "cocktail-party" listening situations.

  5. Prevalence of HHV-6 in cerebrospinal fluid of children younger than 2 years of age with febrile convulsion.

    Directory of Open Access Journals (Sweden)

    Setareh Mamishi

    2014-04-01

    Full Text Available Febrile convulsion is a common disorder in children. Viral infections such as human herpes virus 6 (HHV-6 which results in roseola infantum may contribute to developing seizure. The objective of this study was to determine the prevalence of HHV-6 by detecting DNA in cerebrospinal fluid (CSF of children with febrile convulsion and without any rash of roseola infantum.In this descriptive cross-sectional study, CSF of 100 children younger than 2 years of age with febrile convulsion was evaluated for detecting HHV-6 DNA by PCR. All of them were referred to emergency ward in Pediatric Medical Center from March 2010 to March 2011. General information, clinical manifestations, laboratory tests and outcomes were collected in the questionnaires.One hundred children including 59 males and 41 females were evaluated. HHV-6 was detected from CSF in six patients (6% by PCR. Mean age was 8 months old. All children were younger than 12 months old. The most common primary manifestation was fever alone. None of them had rash. Majority of cases occurred in winter. All patients recovered without any encephalitis.These findings showed that primary infection with HHV-6 is frequently associated with febrile convulsion in infants which may be at risk for subsequent development of epilepsy.

  6. Radio(chemotherapy in elderly patients with oesophageal cancer : a feasible treatment with an outcome consistent with younger patients.

    Directory of Open Access Journals (Sweden)

    Philippe eRochigneux

    2014-05-01

    Full Text Available Background : Although the prevalence of oesophageal cancer increases in elderly patients, its clinical history and outcome after treatment remain poorly described.Methods : Between January 2001 and December 2011, 58 patients (pts older than 75 years-old received 3D conformal radiotherapy (mean dose 51 Gy in two French cancer centres. 47/58 (82% pts received concomitant chemotherapy (with CDDP and/or FU regimens and 8 pts underwent surgery after primary radiochemotherapy (RCT.Results : Median age was 77.9 years and the performance status was 0 or 1 in 89%. Tumours were mainly adenocarcinoma of lower oesophagus or gastroesophageal junction (n=51, 89%, T3T4 (n=54, 95% and N1 (n=44, 77%. The mean follow-up was 21.9 months. In the overall population, the median progression free survival was 9.6 months and median overall survival (OS was 14.5 months. Using univariate analysis, OS was significantly influenced by age (p=0.048, PS (pConclusion : RCT in elderly patients is a feasible treatment and its outcome is close to younger patient’s outcome published in the literature. Surgical resection, after comprehensive geriatric assessment, should be recommended as the standard treatment for adenocarcinoma of lower oesophagus or gastroesophageal junction in elderly patients with good performance status and low comorbidity profile, as it is in younger patients.

  7. A nationwide, retrospective analysis of symptoms, comorbidities, medical care and autopsy findings in cases of fatal pulmonary embolism in younger patients

    DEFF Research Database (Denmark)

    Haunsø, S; Theilade, J; Winkel, B G

    2010-01-01

    Our objective was to provide a comprehensive description of fatal pulmonary embolism (PE) in younger persons. Specifically, we recorded information on symptoms, comorbidity, medical contact, if this had been required, and subsequent autopsy findings.......Our objective was to provide a comprehensive description of fatal pulmonary embolism (PE) in younger persons. Specifically, we recorded information on symptoms, comorbidity, medical contact, if this had been required, and subsequent autopsy findings....

  8. THE ORGANIZATION PEDAGOGICALLY COMFORTABLE COMMUNICATION AND INTERACTION AS THE CONDITION OF SUCCESSFUL OCCURRENCE OF YOUNGER SCHOOLBOYS IN THE EDUCATIONAL ENVIRONMENT OF SCHOOL

    OpenAIRE

    2012-01-01

    One of the actual problems of pedagogical science is the entry of younger schoolchildren into educational school environment. The main purpose of this article is to organize pedagogically comfortable communication and interaction at the stage of entering of younger schoolchildren into educational school environment. In the article on the basis of the analysis of various approaches the concept «successful entry into educational environment » is concretized, the purposes and the maintenance of ...

  9. SHIELD: Observations of Three Candidate Interacting Systems

    Science.gov (United States)

    Ruvolo, Elizabeth; Miazzo, Masao; Cannon, John M.; McNichols, Andrew; Teich, Yaron; Adams, Elizabeth A.; Giovanelli, Riccardo; Haynes, Martha P.; McQuinn, Kristen B.; Salzer, John Joseph; Skillman, Evan D.; Dolphin, Andrew E.; Elson, Edward C.; Haurberg, Nathalie C.; Huang, Shan; Janowiecki, Steven; Jozsa, Gyula; Leisman, Luke; Ott, Juergen; Papastergis, Emmanouil; Rhode, Katherine L.; Saintonge, Amelie; Van Sistine, Angela; Warren, Steven R.

    2017-01-01

    Abstract:The “Survey of HI in Extremely Low-mass Dwarfs” (SHIELD) is a multiwavelength study of local volume low-mass galaxies. Using the now-complete Arecibo Legacy Fast ALFA (ALFALFA) source catalog, 82 systems are identified that meet distance, line width, and HI flux criteria for being gas-rich, low-mass galaxies. These systems harbor neutral gas reservoirs smaller than 3x10^7 M_sun, thus populating the faint end of the HI mass function with statistical confidence for the first time. In a companion poster, we present new Karl G. Jansky Very Large Array D-configuration HI spectral line observations of 32 previously unobserved galaxies. Three galaxies in that study have been discovered to lie in close angular proximity to more massive galaxies. Here we present VLA HI imaging of these candidate interacting systems. We compare the neutral gas morphology and kinematics with optical images from SDSS. We discuss the frequency of low-mass galaxies undergoing tidal interaction in the complete SHIELD sample.Support for this work was provided by NSF grant 1211683 to JMC at Macalester College.

  10. Galactic worms. I - Catalog of worm candidates

    Science.gov (United States)

    Koo, Bon-Chul; Heiles, Carl; Reach, William T.

    1992-01-01

    A catalog of candidates for the Galactic worms that are possibly the walls surrounding the superbubbles is compiled; 118 isolated structures that appear both in H I and in IR (60 and 100 microns). Fifty-two are possibly associated with H II regions. It is found that the 100-micron emissivity increases systematically toward the Galactic interior, which is consistent with the increase of the general interstellar radiation field. The 100-micron emissivity of the structures associated with the H II regions is larger than that of the structures without associated H II regions. The 60-100-micron ratio is large, 0.28 +/- 0.03, which may indicate that the grains associated with the atomic gas have a relatively large population of small grains. Thirty-five structures appear in the 408-MHz continuum. The IR and the radio continuum properties suggest that the 408-MHz continuum emission in those structures is very likely thermal. The implications of these results on the ionization of gas far from the Galactic plane are discussed.

  11. ELECTIONS PENSION FUND CANDIDATE NO 1

    CERN Document Server

    2000-01-01

    This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate : Name: MAURINFirst Name:Guy I have been a member of the personnel since 1967 and as early as 1972 I was involved, in my capacity as President of the Staff Association, in the improvement of the Pension Fund benefits. As for most of us the Pension Fund is the only social provident scheme to which we belong, it is important to ensure that it is well managed and in balance. As a member of the Governing Board since 1974 and Vice-Chairman of this Board since 1977, I have continued to pursue these objectives.One of the main responsibilities of the Governing Board is our asset investment policy. The Investment Committee, of which I am Chairman, must have an overall view of the management of our 4 billion Swiss francs and seek the best yield with minimum risk. The investment structure must continuously be adapted...

  12. ELECTIONS PENSION FUND CANDIDATE NO 2

    CERN Multimedia

    2000-01-01

    This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund.   Candidate: Name: RANJARDFirst Name: Florence Having been a member of the Governing Board of the Pension Fund since 1983 as Guy Maurin’s alternate, I am standing for a further 3-year term of office. Over the past few years work has concentrated essentially on following items: Monitoring of the work of the fund managers and their performances. The three-yearly study of the Fund’s actuarial situation. The pension guarantees ­ second phase. The Fund is approaching its maturity: the level of benefits exceeds contributions. In this context it has to strike a suitable balance between management of the risk from a dynamic investment policy, while a prudent policy avoiding any significant loss of its capital. These will be my concerns within the Governing Board of the Pension Fund if you...

  13. Photon defects in noncommutative standard model candidates

    Energy Technology Data Exchange (ETDEWEB)

    Abel, S.A.; Khoze, V.V. [Durham Univ. (United Kingdom). Center for Particle Theory; Jaeckel, J.; Ringwald, A. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2006-06-15

    Restrictions imposed by gauge invariance in noncommutative spaces together with the effects of ultraviolet/infrared mixing lead to strong constraints on possible candidates for a noncommutative extension of the Standard Model. We study a general class of noncommutative models consistent with these restrictions. Specifically we consider models based upon a gauge theory with the gauge group U(N{sub 1}) x U(N{sub 2}) x.. x U(N{sub m}) coupled to matter fields transforming in the (anti)-fundamental, bi-fundamental and adjoint representations. We pay particular attention to overall trace-U(1) factors of the gauge group which are affected by the ultraviolet/infrared mixing. Typically, these trace-U(1) gauge fields do not decouple sufficiently fast in the infrared, and lead to sizable Lorentz symmetry violating effects in the low-energy effective theory. In a 4-dimensional theory on a continuous space-time making these effects unobservable would require making the effects of noncommutativity tiny, M{sub NC} >> M{sub P}. This severely limits the phenomenological prospects of such models. However, adding additional universal extra dimensions the trace-U(1) factors decouple with a power law and the constraint on the noncommutativity scale is weakened considerably. Finally, we briefly mention some interesting properties of the photon that could arise if the noncommutative theory is modified at a high energy scale. (Orig.)

  14. Virus-like particles as nanovaccine candidates

    Science.gov (United States)

    Guillen, G.; Aguilar, J. C.; Dueñas, S.; Hermida, L.; Iglesias, E.; Penton, E.; Lobaina, Y.; Lopez, M.; Mussachio, A.; Falcon, V.; Alvarez, L.; Martinez, G.; Gil, L.; Valdes, I.; Izquierdo, A.; Lazo, L.; Marcos, E.; Guzman, G.; Muzio, V.; Herrera, L.

    2013-03-01

    The existing vaccines are mainly limited to the microorganisms we are able to culture and produce and/or to those whose killing is mediated by humoral response (antibody mediated). It has been more difficult to develop vaccines capable of inducing a functional cellular response needed to prevent or cure chronic diseases. New strategies should be taken into account in the improvement of cell-based immune responses in order to prevent and control the infections and eventually clear the virus. Preclinical and clinical results with vaccine candidates developed as a vaccine platform based on virus-like particles (VLPs) evidenced their ability to stimulate mucosal as well as systemic immunity. Particles based on envelope, membrane or nucleocapsid microbial proteins induce a strong immune response after nasal or parenteral administration in mice, non-human primates and humans. In addition, the immune response obtained was modulated in a Th1 sense. The VLPs were also able to immunoenhance the humoral and cellular immune responses against several viral pathogens. Studies in animals and humans with nasal and systemic formulations evidenced that it is possible to induce functional immune response against HBV, HCV, HIV and dengue virus. Invited talk at the 6th International Workshop on Advanced Materials Science and Nanotechnology, 30 October - 2 November 2012, Ha Long, Vietnam.

  15. ELECTIONS PENSION FUND 5th candidate

    CERN Multimedia

    2001-01-01

    ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate :  Name : Sonnemann  First Name : Florian Since my arrival at CERN in 1997 I have worked in the accelerator and administrative sectors. I have recently been elected as member of the Staff Council and of the Executive Committee of the Staff Association in which I am actively following matters concerning the Pension Fund. My candidature for the Governing Board of the CERN Pension Fund is mainly motivated to add my part in ensuring a solid financial situation of the Pension Fund. The Pension Fund is our only social security system. I wish to play a role in ensuring that the pensions will remain a secure revenue for all staff membe...

  16. ELECTIONS PENSION FUND CANDIDATE NR 5

    CERN Multimedia

    2001-01-01

    ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate :  Name : Sonnemann  First Name : Florian Since my arrival at CERN in 1997 I have worked in the accelerator and administrative sectors. I have recently been elected as member of the Staff Council and of the Executive Committee of the Staff Association in which I am actively following matters concerning the Pension Fund. My candidature for the Governing Board of the CERN Pension Fund is mainly motivated to add my part in ensuring a solid financial situation of the Pension Fund. The Pension Fund is our only social security system. I wish to play a role in ensuring that the pensions will remain a secure revenue for all staff membe...

  17. ELECTIONS PENSION FUND CANDIDATE NR 1

    CERN Multimedia

    2001-01-01

    ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate : Name : CHIAVERI First Name : Enrico I have been a CERN staff member since 1973 and have always been interested in our working conditions. As a member of the Executive Committee of the Staff Association I participated from 1980 to 1984 in the Working Group on Pensions mandated by the CERN Council. This commitment led to my becoming a member of the Governing Board of the Pension Fund in 1983, since when I have taken an active part in various commissions and working groups (Real Estate Asset Management Committee, Working Group on Actuarial Matters etc.); in so doing I have gained a thorough knowledge of different areas of the Pension Fund. Since ...

  18. Algal Lectins as Potential HIV Microbicide Candidates

    Directory of Open Access Journals (Sweden)

    Dominique Schols

    2012-07-01

    Full Text Available The development and use of topical microbicides potentially offers an additional strategy to reduce the spread of the Human Immunodeficiency Virus (HIV. Carbohydrate-binding agents (CBAs that show specificity for high mannose carbohydrates on the surface of the heavily glycosylated envelope of HIV are endowed with potent anti-HIV activity. In fact, a number of algal lectins such as cyanovirin-N, microvirin, microcystis viridis lectin, scytovirin, Oscillatoria agardhii agglutinin and griffithsin are considered as potential microbicide candidates to prevent the sexual transmission of HIV through topical applications. They not only inhibit infection of cells by cell-free virus but they can also efficiently prevent virus transmission from virus-infected cells to uninfected CD4+ target T-lymphocytes and DC-SIGN-directed capture of HIV-1 and transmission to CD4+ T lymphocytes. This review focuses on the structural properties and carbohydrate specificity of these algal lectins, their antiviral activity against HIV and several other enveloped viruses, their safety profile and viral resistance patterns.

  19. Cerebrospinal fluid biomarker candidates for parkinsonian disorders

    Directory of Open Access Journals (Sweden)

    Radu eConstantinescu

    2013-01-01

    Full Text Available The parkinsonian disorders are a large group of neurodegenerative diseases including idiopathic Parkinson's disease (PD and atypical parkinsonian disorders, such as multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and dementia with Lewy bodies. The etiology of these disorders is not known although it is considered to be a combination of genetic and environmental factors. One of the greatest obstacles for developing efficacious disease-modifying treatment strategies is the lack of biomarkers. Reliable biomarkers are needed for early and accurate diagnosis, to measure disease progression and response to therapy. In this review several of the most promising cerebrospinal biomarker candidates are discussed. Alpha synuclein seems to be intimately involved in the pathogenesis of synucleinopathies and its levels can be measured in the cerebrospinal fluid and in plasma. In a similar way, tau protein accumulation seems to be involved in the pathogenesis of tauopathies. Urate, a potent antioxidant, seems to be associated to the risk of developing PD and with its progression. Neurofilament light chain levels are increased in atypical parkinsonian disorders compared with PD and healthy controls. The new "omics" techniques are potent tools offering new insights in the patho-etiology of these disorders. Some of the difficulties encountered in developing biomarkers are discussed together with future perspectives.

  20. ELECTIONS PENSION FUND CANDIDATE NR 2

    CERN Multimedia

    2001-01-01

    ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate : Name : FRANDSEN First Name : Poul Kjaer  I have been member of the staff since 1974, and member of staff council for more than 12 years, and my main motivation has been to work for improving the social conditions of the CERN staff. A very important pillar of this is a sound and healthy pension fund. A capitalised scheme has been and still is the best choice for assuring the benefits for the CERN staff, present and future, this social system being part of the whole necessary to attract the best staff to the future High Energy Physics in Europe. However, even the hypothetic close down of the Organisation should allow the benefits to exi...

  1. ELECTIONS PENSION FUND 2nd candidate

    CERN Multimedia

    2001-01-01

    ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE CERN EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CAISSE DE PENSIONS / PENSION FUND Caisse de Pensions - ELECTIONS - Pension Fund This candidature has been duly registered and is hereby presented in accordance with paragraph 6.h of the Regulations for Elections to the Governing Board of the Pension Fund. Candidate : Name : FRANDSEN First Name : Poul Kjaer  I have been member of the staff since 1974, and member of staff council for more than 12 years, and my main motivation has been to work for improving the social conditions of the CERN staff. A very important pillar of this is a sound and healthy pension fund. A capitalised scheme has been and still is the best choice for assuring the benefits for the CERN staff, present and future, this social system being part of the whole necessary to attract the best staff to the future High Energy Physics in Europe. However, even the hypothetic close down of the Organisation should allow the benefits to exi...

  2. The FK Comae candidate UX Librae

    Science.gov (United States)

    Bopp, B. W.; Goodrich, B. D.; Africano, J. L.; Noah, P. V.; Meredith, R. J.; Palmer, L. H.; Quigley, R. J.

    1984-01-01

    New optical spectroscopic and photometric data are presented for the active chromosphere FK Com candidate UZ Lib. The star is shown to have an extremely large photometric amplitude in V of 0.35 mag, and its rotation period is established as 4.75 + or - 0.01 days. The optical spectrum is that of an early K giant, broadened by a rotation velocity of approximately 65 km/s. H-alpha is visible as a very broad emission feature, with a profile resembling that seen in FK Com. The emission intensity and profile are variable over the rotation period, with the strongest emission present at photometric minimum, in accord with dark starspot models. The photospheric absorption line profiles show variable asymmetries and distortions which are interpreted as due to the effects of the dark starspot rotating across the line of sight. New radial velocity measures are combined with published data to demonstrate the UZ Lib is a member of a binary system in synchronous rotation with a secondary of mass approximately 0.5 solar masses. This information is considered in light of the conflicting models for the origin of the optical and spectral variability of the FK Com stars, as well as their uncertain evolutionary status.

  3. Older Candidates for Subthalamic Deep Brain Stimulation in Parkinson's Disease Have a Higher Incidence of Psychiatric Serious Adverse Events

    Science.gov (United States)

    Cozac, Vitalii V.; Ehrensperger, Michael M.; Gschwandtner, Ute; Hatz, Florian; Meyer, Antonia; Monsch, Andreas U.; Schuepbach, Michael; Taub, Ethan; Fuhr, Peter

    2016-01-01

    Objective: To investigate the incidence of serious adverse events (SAE) of subthalamic deep brain stimulation (STN-DBS) in elderly patients with Parkinson's disease (PD). Methods: We investigated a group of 26 patients with PD who underwent STN-DBS at mean age 63.2 ± 3.3 years. The operated patients from the EARLYSTIM study (mean age 52.9 ± 6.6) were used as a comparison group. Incidences of SAE were compared between these groups. Results: A higher incidence of psychosis and hallucinations was found in these elderly patients compared to the younger patients in the EARLYSTIM study (p < 0.01). Conclusions: The higher incidence of STN-DBS-related psychiatric complications underscores the need for comprehensive psychiatric pre- and postoperative assessment in older DBS candidates. However, these psychiatric SAE were transient, and the benefits of DBS clearly outweighed its adverse effects. PMID:27375478

  4. Current status of the programs for detection of hearing loss in children younger than six months in Cali

    Directory of Open Access Journals (Sweden)

    Laura González

    2012-02-01

    Full Text Available Background: Data is scarce in Colombia when dealing with the current circumstances of programs for detecting hearing loss in children younger than six months and, therefore, statistical data is limited on congenital or earlyacquired deafness. Studies have been conducted in the country on detection and prevention of hearing problems in the healthcare institutions in Antioquia, Quindío, Cauca, Valle, and Risaralda. All these studies were carried out between 1993 and 1995 and included children older than one year of age, which shows evidence of the lack of knowledge about the importance of early detection in the hearing-communicative health of children. Objective: To identify the current procedures and protocols to detect hearing loss in children younger than six months in Cali through a descriptive research in different healthcare institutions of the city. Methods: A descriptive study was carried out with a population of 722 private, public and/or mixed Health Service Providing Institutions from the city of Cali, registered in the database of the Department of Health of Valle del Cauca, Colombia in February 2007. A list was filled out to determine which of these institutions had services like delivery room and/or growth-development programs and/or audiology services and it was found that these aspects were met in 151 institutions that constituted the research sample. Thereafter, a survey was applied in these institutions to identify the procedures utilized for hearing loss detection, the health professionals that carry this out, and the follow up and the speech-language treatment performed to the children detected. Results: 95% of the healthcare institutions surveyed (144 institutions do not perform procedures to detect hearing loss in children younger than six months. Only six of the private-sector institutions in Cali performed such procedures. The procedures used by these six institutions are all performed with equipment and protocols for

  5. Relationships among cognitive deficits and component skills of reading in younger and older students with developmental dyslexia.

    Science.gov (United States)

    Park, Heeyoung; Lombardino, Linda J

    2013-09-01

    Processing speed deficits along with phonological awareness deficits have been identified as risk factors for dyslexia. This study was designed to examine the behavioral profiles of two groups, a younger (6-8 years) and an older (10-15 years) group of dyslexic children for the purposes of (1) evaluating the degree to which phonological awareness and processing speed deficits occur in the two developmental cohorts; (2) determining the strength of relationships between the groups' respective mean scores on cognitive tasks of phonological awareness and processing speed and their scores on component skills of reading; and (3) evaluating the degree to which phonological awareness and processing speed serve as concurrent predictors of component reading skills for each group. The mean scaled scores for both groups were similar on all but one processing speed task. The older group was significantly more depressed on a visual matching test of attention, scanning, and speed. Correlations between reading skills and the cognitive constructs were very similar for both age-groups. Neither of the two phonological awareness tasks correlated with either of the two processing speed tasks or with any of the three measures of reading. One of the two processing speed measures served as a concurrent predictor of word- and text-level reading in the younger, however, only the rapid naming measure functioned as a concurrent predictor of word reading in the older group. Conversely, phonological processing measures did not serve as concurrent predictors for word-level or text-level reading in either of the groups. Descriptive analyses of individual subjects' deficits in the domains of phonological awareness and processing speed revealed that (1) both linguistic and nonlinguistic processing speed deficits in the younger dyslexic children occurred at higher rates than deficits in phonological awareness and (2) cognitive deficits within and across these two domains were greater in the older

  6. A Catalog of Kepler Habitable Zone Exoplanet Candidates

    Science.gov (United States)

    Kane, Stephen R.; Hill, Michelle L.; Kasting, James F.; Kopparapu, Ravi Kumar; Quintana, Elisa V.; Barclay, Thomas; Batalha, Natalie M.; Borucki, William J.; Ciardi, David R.; Haghighipour, Nader; Hinkel, Natalie R.; Kaltenegger, Lisa; Selsis, Franck; Torres, Guillermo

    2016-10-01

    The NASA Kepler mission ha s discovered thousands of new planetary candidates, many of which have been confirmed through follow-up observations. A primary goal of the mission is to determine the occurrence rate of terrestrial-size planets within the Habitable Zone (HZ) of their host stars. Here we provide a list of HZ exoplanet candidates from the Kepler Q1–Q17 Data Release 24 data-vetting process. This work was undertaken as part of the Kepler HZ Working Group. We use a variety of criteria regarding HZ boundaries and planetary sizes to produce complete lists of HZ candidates, including a catalog of 104 candidates within the optimistic HZ and 20 candidates with radii less than two Earth radii within the conservative HZ. We cross-match our HZ candidates with the stellar properties and confirmed planet properties from Data Release 25 to provide robust stellar parameters and candidate dispositions. We also include false-positive probabilities recently calculated by Morton et al. for each of the candidates within our catalogs to aid in their validation. Finally, we performed dynamical analysis simulations for multi-planet systems that contain candidates with radii less than two Earth radii as a step toward validation of those systems.

  7. A review of the indirect protection of younger children and the elderly through a mass influenza vaccination program in Japan.

    Science.gov (United States)

    Sugaya, Norio

    2014-12-01

    In the past, Japan's strategy for controlling influenza was to vaccinate schoolchildren based on the theory that this could reduce influenza epidemics in the community, and a special program to vaccinate schoolchildren against influenza was begun in 1962. However, the program was discontinued in 1994 because of lack of evidence that it had limited the spread of influenza in the community. In 2001, it was reported that a clear decrease in excess mortality had coincided with the timing of the schoolchild vaccination program. This decrease could have potentially occurred because elderly people were protected by herd immunity generated by the program. Moreover, the program protected the younger siblings of schoolchildren against influenza-associated encephalopathy. Finally, the program was effective in reducing the number of class cancellations and absenteeism from school. During the period when the program was in effect, Japanese schoolchildren served as a barrier against influenza in the community.

  8. Cementless acetabular fixation in patients 50 years and younger at 10 to 18 years of follow-up.

    Science.gov (United States)

    Teusink, Matthew J; Callaghan, John J; Warth, Lucian C; Goetz, Devon D; Pedersen, Douglas R; Johnston, Richard C

    2012-08-01

    The purpose of the study was to evaluate the 10- to 18-year follow-up of cementless acetabular fixation in patients 50 years and younger. We retrospectively reviewed a consecutive group of 118 patients (144 hips) in whom primary total hip arthroplasty had been performed by 2 surgeons using a cementless acetabular component. Two (1.4%) cementless acetabular components were revised because of aseptic loosening. Twenty-four hips (16.7%) were revised for any mechanical failure of the acetabular component mostly related to acetabular liner wear and osteolysis. The average linear wear rate was 0.19 mm per year, which was higher than our previous reports with cemented acetabular fixation. The fiber mesh ingrowth surface of the cementless acetabular component in this study was superior to cemented acetabular components in terms of fixation. However, the high rates of wear and osteolysis have led to poor overall acetabular component construct survivorship.

  9. Similarity-based interference in a working memory numerical updating task: age-related differences between younger and older adults.

    Science.gov (United States)

    Pelegrina, Santiago; Borella, Erika; Carretti, Barbara; Lechuga, M Teresa

    2012-01-01

    Similarity among representations held simultaneously in working memory (WM) is a factor which increases interference and hinders performance. The aim of the current study was to investigate age-related differences between younger and older adults in a working memory numerical updating task, in which the similarity between information held in WM was manipulated. Results showed a higher susceptibility of older adults to similarity-based interference when accuracy, and not response times, was considered. It was concluded that older adults' WM difficulties appear to be due to the availability of stored information, which, in turn, might be related to the ability to generate distinctive representations and to the process of binding such representations to their context when similar information has to be processed in WM.

  10. Younger women's experiences of deciding against delayed breast reconstruction post-mastectomy following breast cancer: An interpretative phenomenological analysis.

    Science.gov (United States)

    Holland, Fiona; Archer, Stephanie; Montague, Jane

    2016-08-01

    Most women do not reconstruct their breast(s) post-mastectomy. The experiences of younger women who maintain this decision, although important to understand, are largely absent in the research literature. This interview-based study uses interpretative phenomenological analysis to explore the experiences of six women, diagnosed with primary breast cancer in their 30s/40s, who decided against delayed reconstruction. Findings reported here focus on one superordinate theme (decision-making) from a larger analysis, illustrating that the women's drive to survive clearly influenced their initial decision-making process. Their tenacity in maintaining their decision is highlighted, despite non-reconstruction sometimes being presented negatively by medical teams. Patient-centred support recommendations are made.

  11. [Violence and accidents among older and younger adults: evidence from the Surveillance System for Violence and Accidents (VIVA), Brazil].

    Science.gov (United States)

    Luz, Tatiana Chama Borges; Malta, Deborah Carvalho; Sá, Naíza Nayla Bandeira de; Silva, Marta Maria Alves da; Lima-Costa, Maria Fernanda

    2011-11-01

    Data from the Brazilian Surveillance System for Violence and Accidents (VIVA) in 2009 were used to examine socio-demographic characteristics, outcomes, and types of accidents and violence treated at 74 sentinel emergency services in 23 Brazilian State capitals and the Federal District. The analysis included 25,201 individuals aged > 20 years (10.1% > 60 years); 89.3% were victims of accidents and 11.9% victims of violence. Hospitalization was the outcome in 11.1% of cases. Compared to the general population, there were more men and non-white individuals among victims of accidents, and especially among victims of violence. As compared to younger adults (20-59 years), accidents and violence against elderly victims showed less association with alcohol, a higher proportion of domestic incidents, more falls and pedestrian accidents, and aggression by family members. Policies for the prevention of accidents and violence should consider the characteristics of these events in the older population.

  12. Early Menarche is Associated With Preference for Masculine Male Faces and Younger Preferred Age to Have a First Child

    Directory of Open Access Journals (Sweden)

    Carlota Batres

    2016-04-01

    Full Text Available One developmental factor that is associated with variation in reproductive strategy is pubertal timing. For instance, women who experience earlier menarche have their first pregnancy earlier and prefer more masculinized male voices. Early menarche may also lead to preferences for masculine faces, but no study has shown such a link. We therefore investigated the relationships between pubertal timing, reproductive plans, sexual attitudes and behaviors, and masculinity preferences in nulliparous women aged 18–30 from the United Kingdom (N = 10,793. We found that women who experienced earlier menarche reported a younger preferred age to have a first child and showed stronger masculinity preferences. This provides evidence that women experiencing early menarche not only have children earlier but notably plan to have children earlier. Additionally, our findings provide evidence that age of menarche influences partner selection, which is instrumental for the implementation of reproductive strategies.

  13. The effect of hormone replacement therapy on mood and everyday memory in younger mid-life women.

    Science.gov (United States)

    Stephens, Christine; Pachana, Nancy A; Bristow, Virginia

    2006-11-01

    Research on the effect of hormone replacement therapy (HRT) on both mood and memory indicates that oestrogen may enhance verbal memory in younger mid-aged women. This study examined the effect of HRT on everyday memory, while accounting for mood changes, in women between ages 40 and 60. A within-subjects comparison of 17 women, showed that mood, everyday memory, working memory, and delayed verbal memory improved after 3 months of HRT use. The improvement in memory was not mediated by mood, but changes in mood were moderated by exercise habits. The results suggest that verbal memory in particular may be enhanced by HRT in this age group, and everyday memory is an important construct to consider in future research.

  14. Antiquarianism, Patriotism and Empire: Transfers of the Cartography of The Travels of Anacharsis the Younger in Greece (1788-1811

    Directory of Open Access Journals (Sweden)

    George Tolias

    2006-01-01

    Full Text Available The aim of this paper is to present an instance of cultural transfer within the field of late Enlightenment antiquarian cartography of Greece, examining a series of maps printed in French and Greek, in Paris and Vienna, between 1788 and 1811 and related to Abbé Barthélemy's Travels of Anacharsis the Younger in Greece. The case study analyses the alterations of the content of the work and the changes of its symbolic functions, alterations due first to the transferral of medium (from a textual description to a cartographic representation and next, to the successive transfers of the work in diverse cultural environments. The transfer process makes it possible to investigate some aspects of the interplay of classical studies, antiquarian erudition and politics as a form of interaction between the French and the Greek intelligentsia of the period.

  15. Results of total joint arthroplasty and joint preserving surgery in younger patients evaluated by alternative outcome measures

    DEFF Research Database (Denmark)

    Klit, Jakob

    2014-01-01

    BACKGROUND: Knee and hip OA is the clinical and pathological outcome of a functional and structural failure of the joint, resulting in pain and physical dysfunction. Despite the similarity in clinical presentation the pathogenesis seems to differ. Where knee OA is associated with obesity and trauma...... bilateral THA, and 44 HR. The study groups received a paper-format questionnaire within one month before surgery and at three, six, and 12 months postoperatively. RESULTS: Study I showed a high willingness to undergo PAO again with the experience and knowledge they have today and improvements were seen...... in younger patients cannot be expected to change the patient's relation to work or annual income. Patients stay sexually active after THA, and female patients experiences positive changes. CONCLUSION: Based on the findings in this thesis PAO patients are satisfied with the outcome at medium to long...

  16. Extracting definition candidates from specialized corpora

    Directory of Open Access Journals (Sweden)

    Senja Pollak

    2014-07-01

    Full Text Available Human knowledge is available in different forms, including domain texts, terminological dictionaries, encyclopaediae, and recently also in computer- understandable representations of domain knowledge, such as taxonomies and ontologies. Since manual domain modeling is costly and time-consuming, researchers in human language technologies have started developing methods and tools for semi-automatic extraction of domain-specific knowledge from unstructured texts, involving tasks, such as terminology extraction, definition extraction, semantic relations extraction, or semi-automatic ontology building. This article presents a methodology for definition extraction from domain corpora, currently available for Slovene and English. Since most of the existing methods and tools are language specific and not developed for minor languages, the main contribution of the dissertation is the developed definition extraction methodology for Slovene. The proposed definition extraction methodology is based on three different approaches to extracting definition candidates. The first follows the traditional pattern-based approach, in which patterns are composed of lemmas and morphosyntactic descriptions; the second approach relies on pairs of domain terms extracted through automatic term extraction; the third approach exploits wordnet hypernym pairs. We propose an original combination of the three approaches. The developed methodology was applied to a real-case problem of modeling the language technologies domain, for which we constructed a comparable Slovene- English corpus consisting of about two million tokens. We extracted more than 3,400 definition candidates, of which over 700 (approximately 480 for Slovene and 230 for English were evaluated as definitions. The results are used as a basis for the Language Technologies Glossary.17 An additional contribution is the proposed domain-modeling pipeline—from corpus uploading and preprocessing to inspecting the

  17. Nonapnea Sleep Disorders in Patients Younger than 65 Years Are Significantly Associated with CKD: A Nationwide Population-Based Study.

    Directory of Open Access Journals (Sweden)

    Hugo You-Hsien Lin

    Full Text Available Nonapnea sleep disorders (NASD and sleep-related problems are associated with poor health outcomes. However, the association between NASD and the development and prognosis of chronic kidney disease (CKD has not been investigated thoroughly. We explored the association between CKD and NASD in Taiwan.We conducted a population-based study using the Taiwan National Health Insurance database with1,000,000 representative data for the period from January 1, 2000 to December 31, 2009. We investigated the incidence and risk of CKD in 7,006 newly diagnosed NASD cases compared with 21,018 people without NASD matched according to age, sex, index year, urbanization, region, and monthly income at a 1:3 ratio.The subsequent risk of CKD was 1.48-foldhigher in the NASD cohort than in the control cohort (95% confidence interval [CI] = 1.26-1.73, p< 0.001. Men, older age, type 2 diabetes mellitus, and gout were significant factors associated with the increased risk of CKD (p< 0.001. Among different types of NASDs, patients with insomnia had a 52% increased risk of developing CKD (95%CI = 1.23-1.84; P<0.01, whereas patients with sleep disturbance had a 49%increased risk of subsequent CKD (95% CI = 1.19-1.87; P<0.001. Younger women (aged < 65 years were at a high risk of CKD with NASD (adjusted hazard ratio, [HR] = 1.81; 95% CI = 1.35-2.40, p< 0.001.In this nationwide population-based cohort study, patients with NASD, particularly men of all ages and women aged younger than 65 years, were at high risk of CKD.

  18. Vaccine-induced boosting of influenza virus-specific CD4 T cells in younger and aged humans.

    Directory of Open Access Journals (Sweden)

    Douglas V Dolfi

    Full Text Available Current yearly influenza virus vaccines induce strain-specific neutralizing antibody (NAb responses providing protective immunity to closely matched viruses. However, these vaccines are often poorly effective in high-risk groups such as the elderly and challenges exist in predicting yearly or emerging pandemic influenza virus strains to include in the vaccines. Thus, there has been considerable emphasis on understanding broadly protective immunological mechanisms for influenza virus. Recent studies have implicated memory CD4 T cells in heterotypic immunity in animal models and in human challenge studies. Here we examined how influenza virus vaccination boosted CD4 T cell responses in younger versus aged humans. Our results demonstrate that while the magnitude of the vaccine-induced CD4 T cell response and number of subjects responding on day 7 did not differ between younger and aged subjects, fewer aged subjects had peak responses on day 14. While CD4 T cell responses were inefficiently boosted against NA, both HA and especially nucleocaspid protein- and matrix-(NP+M specific responses were robustly boosted. Pre-existing CD4 T cell responses were associated with more robust responses to influenza virus NP+M, but not H1 or H3. Finally pre-existing strain-specific NAb decreased the boosting of CD4 T cell responses. Thus, accumulation of pre-existing influenza virus-specific immunity in the form of NAb and cross-reactive T cells to conserved virus proteins (e.g. NP and M over a lifetime of exposure to infection and vaccination may influence vaccine-induced CD4 T cell responses in the aged.

  19. Tracing the successful incorporation of assistive technology into everyday life for younger people with dementia and family carers.

    Science.gov (United States)

    Arntzen, Cathrine; Holthe, Torhild; Jentoft, Rita

    2016-07-01

    Research shows that people with late-onset dementia and their relatives can benefit from using assistive technology (AT). Few researchers have investigated the use and utility of AT in everyday life for younger people with dementia (YPD) and their family carers. The aim of this study is to explore what characterised the implementation process when the AT was experienced as beneficial to the YPD and the family carer in their daily life. The qualitative longitudinal study followed 12 younger people (i.e. those under 65 years of age), who had recently been diagnosed with dementia and 14 of their family carers. In-depth interviews and observations during the process were conducted at the beginning, and were repeated every 3rd month for up to 12 months. The data were analysed, and the participants' experiences further discussed on the basis of embodied, social- and everyday life-situated approaches, in order to provide a deeper understanding of the interactive processes involved in the trajectory. Five elements in the process were identified as important for the experience of usefulness and successful incorporation of AT. The AT had to: (1) be valuable by addressing practical, emotional, and relational challenges; (2) fit well into, or be a better solution for, habitual practice and established strategies; (3) generate positive emotions, and become a reliable and trustworthy tool; (4) be user-friendly, adaptable, and manageable; and (5) interest and engage the family carer. The study demonstrated the importance of understanding the use and utility of AT on the basis of embodied and social participation in daily life. The family carers played a significant role in whether or not, and in which ways, AT was absorbed into the everyday life practice of YPD.

  20. Does that look heavy to you? Perceived weight judgement in lifting actions in younger and older adults.

    Directory of Open Access Journals (Sweden)

    Corrina eMaguinness

    2013-11-01

    Full Text Available When interpreting other people’s movements or actions, observers may not only rely on the visual cues available in the observed movement, but they may also be able to ‘put themselves in the other person’s shoes’ by engaging brain systems involved in both ‘mentalizing’ and motor simulation. The ageing process brings changes in both perceptual and motor abilities, yet little is known about how these changes may affect the ability to accurately interpret other people’s actions. Here we investigated the effect of ageing on the ability to discriminate the weight of objects based on the movements of actors lifting these objects. Stimuli consisted of videos of an actor lifting a small box weighing 0.05 – 0.9 kg or a large box weighting 3 – 18 kg. In a four-alternative forced-choice task, younger and older participants reported the perceived weight of the box in each video. Overall, older participants were less sensitive than younger participants in discriminating the perceived weight of lifted boxes, an effect that was especially pronounced in the small box condition. Weight discrimination performance was better for the large box compared to the small box in both groups, due to greater saliency of the visual cues in this condition. These results suggest that older adults may require more salient visual cues to interpret the actions of others accurately. We discuss the potential contribution of age-related changes in visual and motor function on the observed effects and suggest that older adults’ decline in the sensitivity to subtle visual cues may lead to greater reliance on visual analysis of the observed scene and its semantic context.

  1. Characterization for Fusion Candidate Vanadium Alloys

    Institute of Scientific and Technical Information of China (English)

    T. Muroga; T. Nagasaka; J. M. Chen; Z. Y. Xu; Q. Y. Huang; y. C. Wu

    2004-01-01

    This paper summarizes recent achievements in the characterization of candidate vanadium alloys obtained for fusion in the framework of the Japan-China Core University Program.National Institute for Fusion Science (NIFS) has a program of fabricating high-purity V-4Cr4Ti alloys. The resulting products (NIFS-HEAT-1,2), were characterized by various research groups in the world including Chinese partners. South Western Institute of Physics (SWIP) fabricated a new V-4Cr-4Ti alloy (SWIP-Heat), and carried out a comparative evaluation of hydrogen embrittlement of NIFS-HEATs and SWIP-Heat. The tensile test of hydrogen-doped alloys showed that the NIFS-HEAT maintained the ductility to relatively high hydrogen levels.The comparison of the data with those of previous studies suggested that the reduced oxygen level in the NIFS-HEATs should be responsible for the increased resistance to hydrogen embrittlement.Based on the chemical analysis data of NIFS-HEATs and SWIP-Heats, neutron-induced activation was analyzed in Institute of Plasma Physics (IPP-CAS) as a function of cooling time after the use in the fusion first wall. The results showed that the low level of Co dominates the activity up to 50 years followed by a domination of Nb or Nb and Al in the respective alloys. It was suggested that reduction of Co and Nb, both of which are thought to have been introduced via cross-contamination into the alloys from the molds used should be crucial for reducing further the activation.

  2. A Nearby Old Halo White Dwarf Candidate from the Sloan Digital Sky Survey

    CERN Document Server

    Hall, Patrick B; Harris, Hugh C; Awal, Akshay; Leggett, S K; Kilic, Mukremin; Anderson, Scott F; Gates, Evalyn

    2008-01-01

    We report the discovery of a nearby, old, halo white dwarf candidate from the Sloan Digital Sky Survey. SDSS J110217.48+411315.4 has a proper motion of 1.75 arcsec/year and redder optical colors than all other known featureless (type DC) white dwarfs. We present SDSS imaging and spectroscopy of this object, along with near-infrared photometry obtained at the United Kingdom Infra-Red Telescope. Fitting its photometry with up-to-date model atmospheres, we find that its overall spectral energy distribution is fit reasonably well with a pure hydrogen composition and T_eff~3800 K (assuming log g=8). That temperature and gravity would place this white dwarf at 35 pc from the Sun with a tangential velocity of 290 km/s and space velocities consistent with halo membership; furthermore, its combined main sequence and white dwarf cooling age would be ~11 Gyr. However, if this object is a massive white dwarf, it could be a younger object with a thick disk origin. Whatever its origin, the optical colors of this object are...

  3. A Candidate Planetary-mass Object with a Photoevaporating Disk in Orion

    Science.gov (United States)

    Fang, Min; Kim, Jinyoung Serena; Pascucci, Ilaria; Apai, Dániel; Manara, Carlo Felice

    2016-12-01

    In this work, we report the discovery of a candidate planetary-mass object with a photoevaporating protoplanetary disk, Proplyd 133-353, which is near the massive star θ 1 Ori C at the center of the Orion Nebula Cluster (ONC). The object was known to have extended emission pointing away from θ 1 Ori C, indicating ongoing external photoevaporation. Our near-infrared spectroscopic data and the location on the H-R diagram suggest that the central source of Proplyd 133-353 is substellar (˜M9.5) and has a mass probably less than 13 Jupiter mass and an age younger than 0.5 Myr. Proplyd 133-353 shows a similar ratio of X-ray luminosity to stellar luminosity to other young stars in the ONC with a similar stellar luminosity and has a similar proper motion to the mean one of confirmed ONC members. We propose that Proplyd 133-353 formed in a very low-mass dusty cloud or an evaporating gas globule near θ 1 Ori C as a second generation of star formation, which can explain both its young age and the presence of its disk.

  4. A candidate planetary-mass object with a photoevaporating disk in Orion

    CERN Document Server

    Fang, Min; Pascucci, Ilaria; Apai, Dániel; Manara, Carlo Felice

    2016-01-01

    In this work, we report the discovery of a candidate planetary-mass object with a photoevaporating protoplanetary disk, Proplyd 133-353, which is near the massive star $\\theta^{1}$ Ori C at the center of the Orion Nebula Cluster (ONC). The object was known to have extended emission pointing away from $\\theta^{1}$ Ori C, indicating ongoing external photoevaporation. Our near-infrared spectroscopic data suggests that the central source of Proplyd 133-353 is substellar ($\\sim$M9.5), might have a mass probably less than 13 Jupiter mass and an age younger than 0.5 Myr. Proplyd 133-353 shows a similar ratio of X-ray luminosity to stellar luminosity to other young stars in the ONC with a similar stellar luminosity, and has a similar proper motion to the mean one of confirmed ONC members. We propose that Proplyd 133-353 was formed in a very low-mass dusty cloud near $\\theta^{1}$ Ori C as a second-generation of star formation, which can explain both its young age and the presence of its disk.

  5. Primary-Grade Teacher Candidates' Views on Museum Education

    Science.gov (United States)

    Tas, Ayse Mentis

    2012-01-01

    This study identifies the primary-grade teacher candidates' views on museum education. The research is a descriptive research that used survey model. The study group is made up of 209 primary-grade teacher candidates who were seniors in the Primary-Grade Teaching Program. They were all attending Konya University's Faculty of Education. A survey…

  6. Investigating Academic Achievements and Critical Thinking Dispositions of Teacher Candidates

    Science.gov (United States)

    Karagöl, Ibrahim; Bekmezci, Sinan

    2015-01-01

    The aim of this study is to examine the relationship between academic achievements and critical thinking dispositions of teacher candidates in Faculty of Education and to find out whether critical thinking dispositions and academic achievements scores of teacher candidates differ according to different variables. The population consists of the…

  7. Chemical Literacy Levels of Science and Mathematics Teacher Candidates

    Science.gov (United States)

    Celik, Suat

    2014-01-01

    The goal of this study was to investigate Turkish science and mathematics teacher candidates' levels of attainment in chemical literacy. These candidates had all studied the new Turkish chemistry curriculum in high school. The sample of the study consisted of 112 students, who were first-year students in the Department of Secondary Science…

  8. Five kepler target stars that show multiple transiting exoplanet candidates

    DEFF Research Database (Denmark)

    Steffen..[], Jason H.; Batalha, N. M.; Broucki, W J.;

    2010-01-01

    We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets...

  9. 11 CFR 106.1 - Allocation of expenses between candidates.

    Science.gov (United States)

    2010-01-01

    ... broadcast communication, the attribution shall be determined by the proportion of space or time devoted to... non-Federal candidates, and that is made by a political committee with separate Federal and non...) An authorized expenditure made by a candidate or political committee on behalf of another...

  10. Social Studies Teacher Candidates' Views on Historical Thinking Skills

    Science.gov (United States)

    Ozmen, Cengiz

    2015-01-01

    Current study aimed to present Social Studies teacher candidates' views on historical thinking skills. Study was conducted using qualitative design and working group was composed of a total of 121 teacher candidates (62 females and 59 males) attending Social Studies Teaching Department of Karadeniz Technical University and Adiyaman University…

  11. Preparing Preservice Teacher Candidates to Differentiate Instructional Practices

    Science.gov (United States)

    Ochoa, Bianca R.

    2013-01-01

    This action research study focused on how various grouping strategies influenced preservice teachers' differentiation of instruction. The participants included a third grade mentor teacher and three preservice teacher candidates. The candidate preparation curriculum consisted of seminars, daily field-based learning experiences, and ongoing…

  12. 11 CFR 100.152 - Fundraising costs for Presidential candidates.

    Science.gov (United States)

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Fundraising costs for Presidential candidates... U.S.C. 431) Exceptions to Expenditures § 100.152 Fundraising costs for Presidential candidates. (a... the solicitation of contributions means any cost reasonably related to fundraising activity,...

  13. Opinions of Counselor Candidates Regarding Counseling Skills Training

    Science.gov (United States)

    Aladag, Mine; Yaka, Baris; Koç, Ismet

    2014-01-01

    The aim of this study is to contribute to the enhancement of the quality of counseling skills training and counselor education through the medium of understanding the opinions of counselor candidates regarding counseling skills training. The research group consisted of 67 counselor candidates who voluntarily participated in the study. The research…

  14. Writing Instruction for Teacher Candidates: Strengthening a Weak Curricular Area

    Science.gov (United States)

    Grisham, Dana L.; Wolsey, Thomas Devere

    2011-01-01

    In this case study, two teacher educators in literacy examined teacher candidates' (N = 24) learning of writing instruction across a three-course sequence of literacy methods. Data collected included a survey of candidates' knowledge of writing instruction, their formal observations of writing lessons in their student-teaching placements, a…

  15. Assessing Student Teaching Experiences: Teacher Candidates' Perceptions of Preparedness

    Science.gov (United States)

    Lee, Joohi; Tice, Kathleen; Collins, Denise; Brown, Amber; Smith, Cleta; Fox, Jill

    2012-01-01

    The purpose of this study is to investigate the effectiveness of student teaching experiences by measuring teacher candidates' perceptions of their preparedness. The participants were 130 teacher candidates who had completed their student teaching as part of a program preparing them to teach children in pre-K through grade 4. Teacher candidates…

  16. Fostering the Development of Chemistry Teacher Candidates: A Bioecological Approach

    Science.gov (United States)

    Lewthwaite, Brian; Wiebe, Rick

    2012-01-01

    This ongoing research inquiry investigates through the analysis of teacher candidate experiences the factors influencing two groups of chemistry teacher candidates' development during their extended practica in their second and final year of an after-degree bachelor of education at a university in central Canada. The tenets of Bronfenbrenner's…

  17. DAZLA: an important candidate gene in male subfertility?

    NARCIS (Netherlands)

    Golde, R.J.T. van; Tuerlings, J.H.A.M.; Kremer, J.A.M.; Braat, D.D.M.; Schoute, F.; Hoefsloot, L.H.

    2001-01-01

    PURPOSE: To study the role of the autosomal candidate gene DAZLA (Deleted in AZoospermia Like Autosome) in male subfertility. METHODS: We reviewed clinical data of subfertile men with oligozoospermia or azoospermia, mostly candidates for intracytoplasmic sperm injection (ICSI). Mutation detection wa

  18. Facebook Connection Styles among Physical Education Teacher Candidates

    Science.gov (United States)

    Erdogdu, Murat

    2016-01-01

    The purpose of this study is to determine the Facebook connection styles of physical education (PE) teacher candidates. The participants were composed of 626 (age = 21.21 ± 2.024) physical education teacher candidates from the departments of Physical Education and Sports. They teach in five different universities. It was done in 2014-2015 academic…

  19. Developing Benchmarks to Measure Teacher Candidates' Performance

    Science.gov (United States)

    Frazier, Laura Corbin; Brown-Hobbs, Stacy; Palmer, Barbara Martin

    2013-01-01

    This paper traces the development of teacher candidate benchmarks at one liberal arts institution. Begun as a classroom assessment activity over ten years ago, the benchmarks, through collaboration with professional development school partners, now serve as a primary measure of teacher candidates' performance in the final phases of the…

  20. Sensitive radio survey of obscured quasar candidates

    Science.gov (United States)

    Alexandroff, Rachael M.; Zakamska, Nadia L.; van Velzen, Sjoert; Greene, Jenny E.; Strauss, Michael A.

    2016-12-01

    We study the radio properties of moderately obscured quasars in samples at both low (z ˜ 0.5) and high (z ˜ 2.5) redshift to understand the role of radio activity in accretion, using the Karl G. Jansky Very Large Array (VLA) at 6.0 GHz and 1.4 GHz. Our z ˜ 2.5 sample consists of optically selected obscured quasar candidates, all of which are radio-quiet, with typical radio luminosities of νLν[1.4 GHz] ≲ 1040 erg s-1. Only a single source is individually detected in our deep (rms˜10 μJy) exposures. This population would not be identified by radio-based selection methods used for distinguishing dusty star-forming galaxies and obscured active nuclei. In our pilot A-array study of z ˜ 0.5 radio-quiet quasars, we spatially resolve four of five objects on scales ˜5 kpc and find they have steep spectral indices with an average value of α = -0.75. Therefore, radio emission in these sources could be due to jet-driven or radiatively driven bubbles interacting with interstellar material on the scale of the host galaxy. Finally, we also study the additional population of ˜200 faint ( ˜ 40 μJy-40 mJy) field radio sources observed over ˜120 arcmin2 of our data. 60 per cent of these detections (excluding our original targets) are matched in the Sloan Digital Sky Survey (SDSS) and/or Wide-Field Infrared Survey Explorer (WISE) and are, in roughly equal shares, active galactic nuclei (AGN) at a broad range of redshifts, passive galaxies with no other signs of nuclear activity and infrared-bright but optically faint sources. Spectroscopically or photometrically confirmed star-forming galaxies constitute only a small minority of the matches. Such sensitive radio surveys allow us to address important questions of AGN evolution and evaluate the AGN contribution to the radio-quiet sky.

  1. Almost All of Kepler's Multiple Planet Candidates are Planets

    CERN Document Server

    Lissauer, Jack J; Rowe, Jason F; Bryson, Stephen T; Adams, Elisabeth; Buchhave, Lars A; Ciardi, David R; Cochran, William D; Fabrycky, Daniel C; Ford, Eric B; Fressin, Francois; Geary, John; Gilliland, Ronald L; Holman, Matthew J; Howell, Steve B; Jenkins, Jon M; Kinemuchi, Karen; Koch, David G; Morehead, Robert C; Ragozzine, Darin; Seader, Shawn E; Tanenbaum, Peter G; Torres, Guillermo; Twicken, Joseph D

    2012-01-01

    We present a statistical analysis that demonstrates that the overwhelming majority of Kepler candidate multiple transiting systems (multis) indeed represent true, physically-associated transiting planets. Binary stars provide the primary source of false positives among Kepler planet candidates, implying that false positives should be nearly randomly-distributed among Kepler targets. In contrast, true transiting planets would appear clustered around a smaller number of Kepler targets if detectable planets tend to come in systems and/or if the orbital planes of planets encircling the same star are correlated. There are more than one hundred times as many Kepler planet candidates in multi-candidate systems as would be predicted from a random distribution of candidates, implying that the vast majority are true planets. Most of these multis are multiple planet systems orbiting the Kepler target star, but there are likely cases where (a) the planetary system orbits a fainter star, and the planets are thus significa...

  2. My Younger Brother

    Institute of Scientific and Technical Information of China (English)

    Sally

    2007-01-01

    Look! The boy has a big mouth,two big eyes,a small nose and two big ears.He likes to eat chocolate,but he doesn't like to eat rice no matter how hungry he is. He likes to drink milk but doesn't like to drink water.He is a cute boy with a rosy face.My

  3. The influence of age on health valuations: the older olds prefer functional independence while the younger olds prefer less morbidity

    Directory of Open Access Journals (Sweden)

    Hofman CS

    2015-07-01

    Full Text Available Cynthia S Hofman,1,2 Peter Makai,1 Han Boter,3 Bianca M Buurman,4 Anton J de Craen,5 Marcel GM Olde Rikkert,1 Rogier Donders,2 René JF Melis1 1Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, the Netherlands; 2Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands; 3Department of Epidemiology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; 4Department of Internal Medicine, Section of Geriatric Medicine, Academic Medical Center, Amsterdam, the Netherlands; 5Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, the Netherlands Background: To assess the effectiveness of geriatric interventions, The Older Persons and Informal Caregivers Survey – Composite Endpoint (TOPICS-CEP has been developed based on health valuations of older persons and informal caregivers. This study explored the influence of the raters’ age on the preference weights of TOPICS-CEP’s components.Methods: A vignette study was conducted with 200 raters (mean age ± standard deviation: 72.5±11.8 years; 66.5% female. Profiles of older persons were used to obtain the preference weights for all TOPICS-CEP components: morbidity, functional limitations, emotional wellbeing, pain experience, cognitive functioning, social functioning, self-perceived health, and self-perceived quality of life. The raters assessed the general wellbeing of these vignettes on a 0–10 scale. Mixed linear regression analysis with interaction terms was used to explore the effects of raters’ age on the preference weights.Results: Interaction effects between age and the TOPICS-CEP components showed that older raters gave significantly (P<0.05 more weight to functional limitations and social functioning and less to morbidities and pain experience, compared to younger raters.Conclusion: Researchers examining effectiveness in elderly care need to consider the

  4. Correction of coronal plane deformities around the knee using a tension band plate in children younger than 10 years

    Directory of Open Access Journals (Sweden)

    Ruta M Kulkarni

    2015-01-01

    Full Text Available Background: Guided growth through temporary hemiepiphysiodesis has gained acceptance as the preferred primary treatment in treating pediatric lower limb deformities as it is minimally invasive with a lesser morbidity than the traditional osteotomy. The tension band plate is the most recent development in implants used for temporary hemiepiphysiodesis. Our aim was to determine its safety and efficacy in correcting coronal plane deformities around the knee in children younger than 10 years. Materials and Methods: A total of 24 children under the age of 10 were operated for coronal plane deformities around the knee with a single extra periosteal tension band plate and two nonlocking screws. All the children had a pathological deformity for which a detailed preoperative work-up was carried out to ascertain the cause of the deformity and rule out physiological ones. The average age at hemiepiphysiodesis was 5 years 3 months (range: 2 years to 9 years 1 month. Results: The plates were inserted for an average of 15.625 months (range: 7 months to 29 months. All the patients showed improvement in the mechanical axis. Two patients showed partial correction. Two cases of screw loosening were observed. In the genu valgum group, the tibiofemoral angle improved from a preoperative mean of 19.89° valgus (range: 10° valgus to 40° valgus to 5.72° valgus (range: 2° varus to 10° valgus. In patients with genu varum the tibiofemoral angle improved from a mean of 28.27° varus (range: 13° varus to 41° varus to 1.59° valgus (range: 0-8° valgus. Conclusion: Temporary hemiepiphysiodesis through the application of the tension band plate is an effective method to correct coronal plane deformities around the knee with minimal complications. Its ease and accuracy of insertion has extended the indication of temporary hemiepiphysiodesis to patients younger than 10 years and across a wide variety of diagnosis including pathological physis, which were traditionally

  5. Comparable cerebral oxygenation patterns in younger and older adults during dual-task walking with increasing load

    Directory of Open Access Journals (Sweden)

    Sarah A. Fraser

    2016-10-01

    Full Text Available The neuroimaging literature on dual-task gait clearly demonstrates increased prefrontal cortex (PFC involvement when performing a cognitive task while walking. However, findings from direct comparisons of the cerebral oxygenation patterns of younger (YA and older (OA adults during dual-task walking are mixed and it is unclear how YA and OA respond to increasing cognitive load (difficulty while walking. This functional near infra-red (fNIRS study examined cerebral oxygenation of YA and OA during self-paced dual-task treadmill walking at two different levels of cognitive load (auditory n-back. Changes in accuracy (% as well as oxygenated (HbO and deoxygenated (HbR hemoglobin were examined. For the HbO and HbR measures, eight regions of interest (ROIs were assessed: the anterior and posterior dorsolateral and ventrolateral PFC (aDLPFC, pDLPFC, aVLPFC, pVLPFC in each hemisphere. Nineteen YA (M = 21.83 yrs and 14 OA (M = 66.85 yrs walked at a self-selected pace while performing auditory 1-back and 2-back tasks. Walking alone (single motor: SM and performing the cognitive tasks alone (single cognitive: SC were compared to dual-task walking (DT = SM + SC. In the behavioural data, participants were more accurate in the lowest level of load (1-back compared to the highest (2-back; p ˂ .001. YA were more accurate than OA overall (p = .009, and particularly in the 2-back task (p = .048. In the fNIRS data, both younger and older adults had task effects (SM < DT in specific ROIs for ∆HbO (3 YA, 1 OA and ∆HbR (7 YA, 8 OA. After controlling for walk speed differences, direct comparisons between YA and OA did not reveal significant age differences, but did reveal a difficulty effect in HbO in the left aDLPFC (p = .028 and significant task effects (SM < DT in HbR for 6 of the 8 ROIs. Findings suggest that YA and OA respond similarly to manipulations of cognitive load when walking on a treadmill at a self-selected pace.

  6. PEACE: Pulsar Evaluation Algorithm for Candidate Extraction -- A software package for post-analysis processing of pulsar survey candidates

    CERN Document Server

    Lee, K J; Jenet, F A; Martinez, J; Dartez, L P; Mata, A; Lunsford, G; Cohen, S; Biwer, C M; Rohr, M; Flanigan, J; Walker, A; Banaszak, S; Allen, B; Barr, E D; Bhat, N D R; Bogdanov, S; Brazier, A; Camilo, F; Champion, D J; Chatterjee, S; Cordes, J; Crawford, F; Deneva, J; Desvignes, G; Ferdman, R D; Freire, P; Hessels, J W T; Karuppusamy, R; Kaspi, V M; Knispel, B; Kramer, M; Lazarus, P; Lynch, R; Lyne, A; McLaughlin, M; Ransom, S; Scholz, P; Siemens, X; Spitler, L; Stairs, I; Tan, M; van Leeuwen, J; Zhu, W W

    2013-01-01

    Modern radio pulsar surveys produce a large volume of prospective candidates, the majority of which are polluted by human-created radio frequency interference or other forms of noise. Typically, large numbers of candidates need to be visually inspected in order to determine if they are real pulsars. This process can be labor intensive. In this paper, we introduce an algorithm called PEACE (Pulsar Evaluation Algorithm for Candidate Extraction) which improves the efficiency of identifying pulsar signals. The algorithm ranks the candidates based on a score function. Unlike popular machine-learning based algorithms, no prior training data sets are required. This algorithm has been applied to data from several large-scale radio pulsar surveys. Using the human-based ranking results generated by students in the Arecibo Remote Command enter programme, the statistical performance of PEACE was evaluated. It was found that PEACE ranked 68% of the student-identified pulsars within the top 0.17% of sorted candidates, 95% ...

  7. Theory of mind through the ages: older and middle-aged adults exhibit more errors than do younger adults on a continuous false belief task.

    Science.gov (United States)

    Bernstein, Daniel M; Thornton, Wendy Loken; Sommerville, Jessica A

    2011-10-01

    Theory of mind (ToM), or the ability to understand mental states, is a fundamental aspect of social cognition. Previous research has documented marked advances in ToM in preschoolers, and declines in ToM in older-aged adults. In the present study, younger (n=37), middle-aged (n=20), and older (n=37) adults completed a continuous false belief task measuring ToM. Middle-aged and older adults exhibited more false belief bias than did younger adults, irrespective of language ability, executive function, processing speed, and memory. The authors conclude that ToM declines from younger to older adulthood, independent of age-related changes to domain-general cognitive functioning.

  8. A Catalog of Kepler Habitable Zone Exoplanet Candidates

    CERN Document Server

    Kane, Stephen R; Kasting, James F; Kopparapu, Ravi Kumar; Quintana, Elisa V; Barclay, Thomas; Batalha, Natalie M; Borucki, William J; Ciardi, David R; Haghighipour, Nader; Hinkel, Natalie R; Kaltenegger, Lisa; Selsis, Franck; Torres, Guillermo

    2016-01-01

    The NASA Kepler mission has discovered thousands of new planetary candidates, many of which have been confirmed through follow-up observations. A primary goal of the mission is to determine the occurrance rate of terrestrial-size planets within the Habitable Zone (HZ) of their host stars. Here we provide a list of HZ exoplanet candidates from the Kepler Data Release 24 Q1-Q17 data vetting process. This work was undertaken as part of the Kepler Habitable Zone Working Group. We use a variety of criteria regarding HZ boundaries and planetary sizes to produce complete lists of HZ candidates, including a catalog of 104 candidates within the optimistic HZ and 20 candidates with radii less than two Earth radii within the conservative HZ. We cross-match our HZ candidates with the Data Release 25 stellar properties and confirmed planet properties to provide robust stellar parameters and candidate dispositions. We also include false positive probabilities recently calculated by Morton et al. (2016) for each of the cand...

  9. Pathogenic Network Analysis Predicts Candidate Genes for Cervical Cancer

    Directory of Open Access Journals (Sweden)

    Yun-Xia Zhang

    2016-01-01

    Full Text Available Purpose. The objective of our study was to predicate candidate genes in cervical cancer (CC using a network-based strategy and to understand the pathogenic process of CC. Methods. A pathogenic network of CC was extracted based on known pathogenic genes (seed genes and differentially expressed genes (DEGs between CC and normal controls. Subsequently, cluster analysis was performed to identify the subnetworks in the pathogenic network using ClusterONE. Each gene in the pathogenic network was assigned a weight value, and then candidate genes were obtained based on the weight distribution. Eventually, pathway enrichment analysis for candidate genes was performed. Results. In this work, a total of 330 DEGs were identified between CC and normal controls. From the pathogenic network, 2 intensely connected clusters were extracted, and a total of 52 candidate genes were detected under the weight values greater than 0.10. Among these candidate genes, VIM had the highest weight value. Moreover, candidate genes MMP1, CDC45, and CAT were, respectively, enriched in pathway in cancer, cell cycle, and methane metabolism. Conclusion. Candidate pathogenic genes including MMP1, CDC45, CAT, and VIM might be involved in the pathogenesis of CC. We believe that our results can provide theoretical guidelines for future clinical application.

  10. Specifying the interrelationship between exposure to violence and parental monitoring for younger versus older adolescents: a five year longitudinal test.

    Science.gov (United States)

    Spano, Richard; Rivera, Craig; Vazsonyi, Alexander T; Bolland, John M

    2012-03-01

    Five waves of longitudinal data collected from 349 African American youth living in extreme poverty were used to examine the interrelationship between exposure to violence and parenting during adolescence. Semi-parametric group based modeling was used to identify trajectories of parental monitoring and exposure to violence from T1 to T5. Results from these analyses revealed: (1) a trajectory of declining parental monitoring for 48% of youth; and (2) four distinct trajectories of exposure to violence. Multivariate findings were largely consistent with the ecological-transactional model of community violence. Youth with stable and/or increasing trajectories of exposure to violence were more likely than youth with stable-low exposure to violence to have declining parental monitoring, but additional analyses revealed a similar pattern of findings for younger adolescents (age 9-11 T1), but no evidence of linkages between trajectories of exposure to violence and parental monitoring for older adolescents (age 12-16 T1). The theoretical and policy implications of these findings as well as areas for future research are also discussed.

  11. The impact of red light running camera flashes on younger and older drivers' attention and oculomotor control.

    Science.gov (United States)

    Wright, Timothy J; Vitale, Thomas; Boot, Walter R; Charness, Neil

    2015-12-01

    Recent empirical evidence has suggested that the flashes associated with red light running cameras (RLRCs) distract younger drivers, pulling attention away from the roadway and delaying processing of safety-relevant events. Considering the perceptual and attentional declines that occur with age, older drivers may be especially susceptible to the distracting effects of RLRC flashes, particularly in situations in which the flash is more salient (a bright flash at night compared with the day). The current study examined how age and situational factors potentially influence attention capture by RLRC flashes using covert (cuing effects) and overt (eye movement) indices of capture. We manipulated the salience of the flash by varying its luminance and contrast with respect to the background of the driving scene (either day or night scenes). Results of 2 experiments suggest that simulated RLRC flashes capture observers' attention, but, surprisingly, no age differences in capture were observed. However, an analysis examining early and late eye movements revealed that older adults may have been strategically delaying their eye movements in order to avoid capture. Additionally, older adults took longer to disengage attention following capture, suggesting at least 1 age-related disadvantage in capture situations. Findings have theoretical implications for understanding age differences in attention capture, especially with respect to capture in real-world scenes, and inform future work that should examine how the distracting effects of RLRC flashes influence driver behavior.

  12. Pancreatic-specific autoantibodies to glycoprotein 2 mirror disease location and behaviour in younger patients with Crohn’s disease

    Directory of Open Access Journals (Sweden)

    Bogdanos Dimitrios P

    2012-08-01

    Full Text Available Abstract Background Glycoprotein 2 (GP2 was discovered as the major autoantigen of Crohn’s disease (CD-specific pancreatic autoantibodies (PAB. We investigated anti-GP2 IgA and IgG antibodies as novel serological parameters in CD and assessed their association with distinct disease phenotypes. Methods Anti-GP2 and anti-Saccharomyces cerevisiae (ASCA IgA and IgG were detected by ELISA employing recombinant human GP2 and phosphopeptidomannan, respectively and PAB by indirect immunofluorescence (IIF in 271 sera, 169 with CD and 102 with ulcerative colitis (UC. As healthy controls 160 adult blood donors and 65 children were included. Results Anti-GP2 IgG and/or IgA were more prevalent in CD (51/169, 30.2% than in UC (9/102, 8.9% patients and in controls (9/225, 4% (p  Conclusions Anti-GP2 IgG and IgA, constituting novel CD specific autoantibodies, appear to be associated with distinct disease phenotypes identifying patients at a younger age, with ileocolonic location, and stricturing behaviour with perianal disease.

  13. Advisory Committee on Immunization Practices Recommended Immunization Schedule for Children and Adolescents Aged 18 Years or Younger - United States, 2017.

    Science.gov (United States)

    Robinson, Candice L; Romero, José R; Kempe, Allison; Pellegrini, Cynthia

    2017-02-10

    In October 2016, the Advisory Committee on Immunization Practices (ACIP) approved the Recommended Immunization Schedule for Children and Adolescents Aged 18 Years or Younger-United States, 2017. The 2017 child and adolescent immunization schedule summarizes ACIP recommendations, including several changes from the 2016 immunization schedules, in three figures, and footnotes for the figures. These documents can be found on the CDC immunization schedule website (https://www.cdc.gov/vaccines/schedules/index.html). These immunization schedules are approved by ACIP (https://www.cdc.gov/vaccines/acip/index.html), the American Academy of Pediatrics (https://www.aap.org), the American Academy of Family Physicians (https://www.aafp.org), and the American College of Obstetricians and Gynecologists (http://www.acog.org). Health care providers are advised to use the figures and the combined footnotes together. The full ACIP recommendations for each vaccine, including contraindications and precautions, can be found at https://www.cdc.gov/vaccines/hcp/acip-recs/index.html. Providers should be aware that changes in recommendations for specific vaccines can occur between annual updates to the childhood/adolescent immunization schedules. If errors or omissions are discovered within the child and adolescent schedule, CDC posts revised versions on the CDC immunization schedule website.

  14. Social engagement and health in younger, older, and oldest-old adults in the Louisiana Healthy Aging Study.

    Science.gov (United States)

    Cherry, Katie E; Walker, Erin Jackson; Brown, Jennifer Silva; Volaufova, Julia; LaMotte, Lynn R; Welsh, David A; Su, L Joseph; Jazwinski, S Michal; Ellis, Rebecca; Wood, Robert H; Frisard, Madlyn I

    2013-02-01

    Social support has been shown to influence health outcomes in later life. In this study, we focus on social engagement as an umbrella construct that covers select social behaviors in a life span sample that included oldest-old adults, a segment of the adult population for whom very little data currently exist. We examined relationships among social engagement, positive health behaviors, and physical health to provide new evidence that addresses gaps in the extant literature concerning social engagement and healthy aging in very old adults. Participants were younger (21-59 years), older (60-89 years), and oldest-old (90-97 years) adults (N = 364) in the Louisiana Healthy Aging Study (LHAS). Linear regression analyses indicated that age, gender, and hours spent outside of the house were significantly associated with self-reported health. The number of clubs and hours outside of home were more important factors in the analyses of objective health status than positive health behaviors, after considering age group and education level. These data strongly suggest that social engagement remains an important determinant of physical health into very late adulthood. The discussion focuses on practical applications of these results including social support interventions to maintain or improve late-life health.

  15. A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables

    DEFF Research Database (Denmark)

    Endesfelder, David; McGranahan, Nicholas; Birkbak, Nicolai Juul;

    2011-01-01

    . In a breast cancer meta-analysis of 2423 patients we examine the relationship between clinicopathological parameters and two distinct chromosomal instability gene expression signatures in order to address whether younger age at diagnosis is associated with increased tumour genome instability. We find that CIN......, assessed by the two independently derived CIN expression signatures, is significantly associated with increased tumour size, ER negative or HER2 positive disease, higher tumour grade and younger age at diagnosis in ER negative breast cancer. These data support the hypothesis that chromosomal instability...

  16. Planet Hunters VI: The First Kepler Seven Planet Candidate System and 13 Other Planet Candidates from the Kepler Archival Data

    CERN Document Server

    Schmitt, Joseph R; Fischer, Debra A; Jek, Kian J; Moriarty, John C; Boyajian, Tabetha S; Schwamb, Megan E; Lintott, Chris; Smith, Arfon M; Parrish, Michael; Schawinski, Kevin; Lynn, Stuart; Simpson, Robert; Omohundro, Mark; Winarski, Troy; Goodman, Samuel J; Jebson, Tony; Lacourse, Daryll

    2013-01-01

    We report the discovery of 14 new transiting planet candidates in the Kepler field from the Planet Hunters citizen science program. None of these candidates overlap with Kepler Objects of Interest (KOIs), and five of the candidates were missed by the Kepler Transit Planet Search (TPS) algorithm. The new candidates have periods ranging from 124-904 days, eight residing in their host star's habitable zone (HZ) and two (now) in multiple planet systems. We report the discovery of one more addition to the six planet candidate system around KOI-351, marking the first seven planet candidate system from Kepler. Additionally, KOI-351 bears some resemblance to our own solar system, with the inner five planets ranging from Earth to mini-Neptune radii and the outer planets being gas giants; however, this system is very compact, with all seven planet candidates orbiting $\\lesssim 1$ AU from their host star. We perform a numerical integration of the orbits and show that the system remains stable for over 100 million years....

  17. Campaigning on the Internet: 2008 Presidential General Election Candidate Webpage

    Directory of Open Access Journals (Sweden)

    William L. Benoit

    2016-12-01

    Full Text Available The Internet is becoming an increasingly important component of political campaigns. This study employed content analysis to apply Functional Theory and Issue Ownership Theory to Obama’s and McCain’s presidential candidate webpages in the 2008 campaign. Acclaims (92% were more common than attacks (98%; defenses did not occur in this sample. Policy (82% was addressed more than character (18%. When discussing policy, these candidates addressed future plans most frequently, followed by general goals and then past deeds; on character, candidates discussed ideals, then personal qualities, and then leadership ability. This study shows that as candidates use the Internet to reach voters, their webpages conform to theoretical expectations.

  18. Spectroscopy of candidate electromagnetic counterparts to gravitational wave sources

    CERN Document Server

    Steele, Iain A; Piascik, Andrzej S

    2016-01-01

    A programme of worldwide, multi-wavelength electromagnetic follow-up of sources detected by gravitational wave detectors is in place. Following the discovery of GW150914 and GW151226, wide field imaging of their sky localisations identified a number of candidate optical counterparts which were then spectrally classified. The majority of candidates were found to be supernovae at redshift ranges similar to the GW events and were thereby ruled out as a genuine counterpart. Other candidates ruled out include AGN and solar system objects. Given the GW sources were black hole binary mergers, the lack of an identified electromagnetic counterpart is not surprising. However the observations show that is it is possible to organise and execute a campaign that can eliminate the majority of potential counterparts. Finally we note the existence of a "classification gap" with a significant fraction of candidates going unclassified.

  19. 11 CFR 100.148 - Volunteer activity for candidate.

    Science.gov (United States)

    2010-01-01

    ..., magazines, billboards, direct mail or similar types of general public communication or political advertising... developed by the candidate. But see 11 CFR 100.24, 104.17(a), and part 300, subparts D and E for...

  20. 11 CFR 100.88 - Volunteer activity for candidates.

    Science.gov (United States)

    2010-01-01

    ..., billboards, direct mail or similar types of general public communication or political advertising. (b) The... developed by the candidate. But see 11 CFR 100.24, 104.17(a), and part 300, subparts D and E for...

  1. 15 CFR 922.21 - Selection of active candidates.

    Science.gov (United States)

    2010-01-01

    ... from the SEL for Active Candidate consideration based on a preliminary assessment of the designation... environmental impact statement shall be published in the Federal Register and in newspapers in the area(s)...

  2. The impact of alternate fuels on future candidate automotive engines

    Energy Technology Data Exchange (ETDEWEB)

    Rahnke, C.J.; Nichols, R.J.

    1982-06-01

    The thermal efficiency that could occur in the future for a variety of automotive engine candidates operating on conventional and alternate fuels is projected based on current automotive engine development trends and the special characteristics of the various alternate fuels. The multi-fuel engine candidates include mixture cycle and direct injection reciprocating engines, as well as adiabatic turbocompound engines and advanced gas turbine and Stirling engines. The alternate fuels considered are propane, methanol, ethanol, diesel and methane.

  3. Radiative Neutrino Mass via Both Minimal Dark Matter Candidates

    CERN Document Server

    Ahriche, Amine; Nasri, Salah; Picek, Ivica

    2016-01-01

    We identify a minimal model achieving one-loop radiative neutrino masses due to couplings with dark matter. Interestingly the model contains both the quintuplet fermion and the septuplet scalar identified as minimal dark matter candidates by Cirelli, Fornengo and Strumia - it gives radiative neutrino mass due to both minimal dark matter candidates. The model is related to those proposed in a recent work (dubbed minimal R$\

  4. Transiting exoplanet candidates from K2 Campaigns 5 and 6

    Science.gov (United States)

    Pope, Benjamin J. S.; Parviainen, Hannu; Aigrain, Suzanne

    2016-10-01

    We introduce a new transit search and vetting pipeline for observations from the K2 mission, and present the candidate transiting planets identified by this pipeline out of the targets in Campaigns 5 and 6. Our pipeline uses the Gaussian process-based K2SC code to correct for the K2 pointing systematics and simultaneously model stellar variability. The systematics-corrected, variability-detrended light curves are searched for transits with the box-least-squares method, and a period-dependent detection threshold is used to generate a preliminary candidate list. Two or three individuals vet each candidate manually to produce the final candidate list, using a set of automatically generated transit fits and assorted diagnostic tests to inform the vetting. We detect 145 single-planet system candidates and 5 multi-planet systems, independently recovering the previously published hot Jupiters EPIC 212110888b, WASP-55b (EPIC 212300977b) and Qatar-2b (EPIC 212756297b). We also report the outcome of reconnaissance spectroscopy carried out for all candidates with Kepler magnitude Kp ≤ 13, identifying 12 targets as likely false positives. We compare our results to those of other K2 transit search pipelines, noting that ours performs particularly well for variable and/or active stars, but that the results are very similar overall. All the light curves and code used in the transit search and vetting process are publicly available, as are the follow-up spectra.

  5. Searching for information on the World Wide Web with a search engine: a pilot study on cognitive flexibility in younger and older users.

    Science.gov (United States)

    Dommes, Aurelie; Chevalier, Aline; Rossetti, Marilyne

    2010-04-01

    This pilot study investigated the age-related differences in searching for information on the World Wide Web with a search engine. 11 older adults (6 men, 5 women; M age=59 yr., SD=2.76, range=55-65 yr.) and 12 younger adults (2 men, 10 women; M=23.7 yr., SD=1.07, range=22-25 yr.) had to conduct six searches differing in complexity, and for which a search method was or was not induced. The results showed that the younger and older participants provided with an induced search method were less flexible than the others and produced fewer new keywords. Moreover, older participants took longer than the younger adults, especially in the complex searches. The younger participants were flexible in the first request and spontaneously produced new keywords (spontaneous flexibility), whereas the older participants only produced new keywords when confronted by impasses (reactive flexibility). Aging may influence web searches, especially the nature of keywords used.

  6. Original Research: Adipose-derived stem cells from younger donors, but not aging donors, inspire the host self-healing capability through its secreta.

    Science.gov (United States)

    Ma, Ning; Qiao, Chenhui; Zhang, Weihua; Luo, Hong; Zhang, Xin; Liu, Donghai; Zang, Suhua; Zhang, Liang; Bai, Jingyun

    2017-01-01

    Adipose-derived stem cells demonstrate promising effects in promoting cutaneous wound healing, but the mechanisms are still not well defined and contradictory views are still debatable. In the present research, we established a mouse cutaneous wound model and investigated the effects of adipose-derived stem cells in wound healing. Adipocyte, adipose-derived stem cells, and epidermal keratinocyte stem cells were isolated from younger and aged donors according to the standard protocol. The conditioned medium either from adipose-derived stem cells or from adipocytes was used to treat epidermal keratinocyte cells. The results showed that adipocytes or adipose-derived stem cells isolated from younger donors demonstrated mild advantage over those cells isolated from aging donors. Adipose-derived stem cells showed stronger stimuli than adipocytes, and the adipose-derived stem cells or adipocytes from younger donors enabled to support higher growth rate of keratinocyte stem cells. The invasion of vasculature was observed at day 10 after posttransplantation in the mice bearing the keratinocyte stem cells or combination of keratinocyte stem cells with adipose-derived stem cells; however, simply inoculating keratinocyte stem cells from aging donors did not result in vasculature formation. Adipose-derived stem cells isolated from younger donors were able to inspire the host's self-healing capabilities, and age-associated factors should be taken into consideration when designing a feasible therapeutic treatment for skin regeneration.

  7. Cognitive control adjustments in healthy older and younger adults: Conflict adaptation, the error-related negativity (ERN), and evidence of generalized decline with age.

    Science.gov (United States)

    Larson, Michael J; Clayson, Peter E; Keith, Cierra M; Hunt, Isaac J; Hedges, Dawson W; Nielsen, Brent L; Call, Vaughn R A

    2016-03-01

    Older adults display alterations in neural reflections of conflict-related processing. We examined response times (RTs), error rates, and event-related potential (ERP; N2 and P3 components) indices of conflict adaptation (i.e., congruency sequence effects) a cognitive control process wherein previous-trial congruency influences current-trial performance, along with post-error slowing, correct-related negativity (CRN), error-related negativity (ERN) and error positivity (Pe) amplitudes in 65 healthy older adults and 94 healthy younger adults. Older adults showed generalized slowing, had decreased post-error slowing, and committed more errors than younger adults. Both older and younger adults showed conflict adaptation effects; magnitude of conflict adaptation did not differ by age. N2 amplitudes were similar between groups; younger, but not older, adults showed conflict adaptation effects for P3 component amplitudes. CRN and Pe, but not ERN, amplitudes differed between groups. Data support generalized declines in cognitive control processes in older adults without specific deficits in conflict adaptation.

  8. Short-Term Changes in General and Memory-Specific Control Beliefs and Their Relationship to Cognition in Younger and Older Adults

    Science.gov (United States)

    Bielak, Allison A. M.; Hultsch, David F.; Levy-Ajzenkopf, Judi; MacDonald, Stuart W. S.; Hunter, Michael A.; Strauss, Esther

    2007-01-01

    We examined short-term changes in younger and older adults' control beliefs. Participants completed measures of general and memory-specific competence and locus of control on 10 bi-monthly occasions. At each occasion, participants rated their control beliefs prior to and following completion of a battery of cognitive tasks. Exposure to the set of…

  9. Assessment of the level of development of younger students basic national values ​​as a socio-pedagogical problem

    Directory of Open Access Journals (Sweden)

    Galina Myss

    2013-04-01

    Full Text Available In the article the problem of development of pupils is updated primary level of basic national values ​​in the context of the concept of spiritual and moral development and education of a citizen of Russia, offers original position on the selection criteria and indicators of assimilation younger students basic national values​​.

  10. Older Sibling Support of Younger Siblings' Socio-Emotional Development: A Multiple-Case Study of Second-Generation Mexican and Honduran Children's Initiative and Co-Construction

    Science.gov (United States)

    Palacios, Natalia; Kibler, Amanda K.; Yoder, Michelle; Baird, Ashley Simpson; Bergey, Rebecca

    2016-01-01

    Siblings play a critical role in the socialization experiences of their younger siblings. Societal values, standards, and customs are transmitted and created through the process of modeling and the construction of shared meaning. It follows, therefore, that the process of socialization may be culturally dependent. Using multiple case studies of…

  11. A study of the validity of urinary tract infection diagnosis in children younger than two years of age at Hvidovre Hospital

    DEFF Research Database (Denmark)

    Roed-Petersen, Casper; Møller, Alice Friis; Høgh, Birthe

    2008-01-01

    INTRODUCTION: The aim of this study is to validate the diagnosis of urinary tract infection (UTI) concerning false-positive diagnoses in children younger than two years of age at Hvidovre Hospital. MATERIALS AND METHODS: The material consists of 89 children (50 girls and 39 boys) diagnosed...

  12. Age-Related Differences in the Effect of Psychological Distress on Mortality: Type D Personality in Younger versus Older Patients with Cardiac Arrhythmias

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    Johan Denollet

    2013-01-01

    Full Text Available Background. Mixed findings in biobehavioral research on heart disease may partly be attributed to age-related differences in the prognostic value of psychological distress. This study sought to test the hypothesis that Type D (distressed personality contributes to an increased mortality risk following implantable cardioverter defibrillator (ICD treatment in younger patients but not in older patients. Methods. The Type D Scale (DS14 was used to assess general psychological distress in 455 younger (≤70 y,. Cardiac resynchronization therapy (CRT, but not Type D personality, was associated with increased mortality in older patients. Among younger patients, however, Type D personality was associated with an adjusted hazard ratio = 1.91 (95% CI 1.09–3.34 and 2.26 (95% CI 1.16–4.41 for all-cause and cardiac mortality; other predictors were increasing age, CRT, appropriate shocks, ACE-inhibitors, and smoking. Conclusion. Type D personality was independently associated with all-cause and cardiac mortality in younger ICD patients but not in older patients. Cardiovascular research needs to further explore age-related differences in psychosocial risk.

  13. FORMATION OF COMMUNICATIVE ABILITIES OF YOUNGER SCHOOL STUDENTS IN TEACHING AND EDUCATIONAL ACTIVITY IN THE CONDITIONS OF CONTINUITY OF FGOS OF HOO AND FGOS TO

    Directory of Open Access Journals (Sweden)

    Ksenia Pavlovna Zaytseva

    2015-12-01

    Full Text Available In this work we will consider features of formation of communicative abilities of younger school students as a basis of their social adaptation. For this purpose we will reveal features of the teaching and educational activity of younger school students creating conditions for formation of their communicative abilities and we will show as the communicative abilities formed in teaching and educational activity can be directed on training of younger school students for social adaptation.Purpose. In the Federal state educational standard of the general education (FGOS of the second generation transition from minimizatsionny approach in education is designated. Communicative abilities are a basis not only productive inclusion of pupils in interpersonal relationship with contemporaries and adults in educational activity, socially important for them, but also basis for an exit in system of broader social relationship with people and the world in general.Methodology. The basis of research is formed by the empirical – studying and the analysis of literature, normative documents and textbooks for elementary school; supervision, poll (oral and written.Results. Results of work consists preparation of methodical ensuring process of formation of communicative abilities of younger school students in teaching and educational activity as bases of their social adaptation: Socialization programs.Practical implications. Results of research can be used by elementary school teachers in teaching and educational activity, and also students when writing theses and carrying out experiment.

  14. Endotracheal intubation with airtraq® versus storz® videolaryngoscope in children younger than two years - a randomized pilot-study

    DEFF Research Database (Denmark)

    Sørensen, Martin Kryspin; Holm-Knudsen, Rolf

    2012-01-01

    New laryngoscopes have become available for use in small children. The aim of the study was to compare the Storz® videolaryngoscope (SVL) to the Airtraq® Optical laryngoscope (AOL) for tracheal intubation in children younger than two years of age who had a normal airway assessment. Our hypothesis...

  15. Parental Perceptions of Child Behavior Problems, Parenting Self-Esteem, and Mothers' Reported Stress in Younger and Older Hyperactive and Normal Children.

    Science.gov (United States)

    Mash, Eric J.; Johnston, Charlotte

    1983-01-01

    Examined parental perceptions of child behavior, parenting self-esteem, and mothers' reported stress for younger and older hyperactive and normal children. Parenting self-esteem was lower in parents of hyperactives than in parents of normal children. Self-esteem related to skill/knowledge as a parent was age related. (Author/RC)

  16. Exercise- and methylcholine-induced sweating responses in older and younger men: effect of heat acclimation and aerobic fitness

    Science.gov (United States)

    Inoue, Y.; Havenith, George; Kenney, W. Larry; Loomis, Joseph L.; Buskirk, Elsworth R.

    The purpose of this investigation was to examine the effects of aging and aerobic fitness on exercise- and methylcholine-induced sweating responses during heat acclimation. Five younger [Y group - age: 23+/-1 (SEM) years; maximal oxygen consumption (V.O2max): 47+/-3 ml.kg-1.min-1], four highly fit older (HO group - 63+/-3 years; 48+/-4 ml.kg-1.min-1) and five normally fit older men (NO group - 67+/-3 years; 30+/-1 ml.kg-1.min-1) who were matched for height, body mass and percentage fat, were heat acclimated by daily cycle exercise ( 35% V.O2max for 90 min) in a hot (43°C, 30% RH) environment for 8 days. The heat acclimation regimen increased performance time, lowered final rectal temperature (Tre) and percentage maximal heart rate (%HRmax), improved thermal comfort and decreased sweat sodium concentration similarly in all groups. Although total body sweating rates (M.sw) during acclimation were significantly greater in the Y and HO groups than in the NO group (Pexercise) values, compared to the other groups (PHO>NO, and on the forearm Y=HO>NO. No group differences were observed for activated sweat gland density at any site. The SGO at the respective sites increased in the post-acclimation test regardless of group (Pexercised at the same relative exercise intensity. Furthermore, the changes induced by acclimation appear associated with an age-related decrease in V.O2max. However methylcholine-activated SGO and the magnitude of improvement of SGO with acclimation are related not only to V.O2max but also to aging, suggesting that sensitivity to cholinergic stimulation decreases with aging.

  17. Racial disparities in all-cause mortality among younger commercially insured women with incident metastatic breast cancer.

    Science.gov (United States)

    Leopold, Christine; Wagner, Anita K; Zhang, Fang; Lu, Christine Y; Earle, Craig; Nekhlyudov, Larissa; Degnan, Dennis-Ross; Frank Wharam, J

    2016-07-01

    Racial disparities in breast cancer mortality persist and are likely related to multiple factors. Over the past decade, progress has been made in treating metastatic breast cancer, particularly in younger women. Whether disparities exist in this population is unknown. Using administrative claims data between 2000 and 2011 (OptumInsight, Eden Prairie, MN) of members insured through a large national US health insurer, we identified women aged 25-64 years diagnosed with incident metastatic breast cancer diagnosed between November 1, 2000, and December 31, 2008. We examined time from diagnosis to death, with up to 3 years of follow-up. We stratified analyses by geocoded race and socio-economic status, age-at-diagnosis, morbidity score, US region of residence, urban/non-urban, and years of diagnosis. We constructed Kaplan-Meier survival plots and analyzed all-cause mortality using multivariate Cox proportional hazard models. Among 6694 women with incident metastatic breast cancer (78 % Caucasian, 4 % African American, and 18 % other), we found higher mortality rates among women residing in predominantly African American versus Caucasian neighborhoods (hazard ratio (HR) 1.84; 95 % confidence interval, CI 1.39-2.45), women with high versus lower morbidity (HR 1.30 [1.12-1.51]), and women whose incident metastatic diagnosis was during 2000-2004 versus 2005-2008 (HR 1.60 [1.39-1.83]). Caucasian (HR 0.61 [0.52-0.71]) but not African American women (HR not significant) experienced improved mortality in 2005-2008 versus 2000-2004. Despite insured status, African American women and women with multi-morbidity had poorer survival. Only Caucasian women had improved mortality over time. Modifiable risk factors for increased mortality need to be addressed in order to reduce disparities.

  18. Enlarged Multilocus Data set Provides Surprisingly Younger Time of Origin for the Plethodontidae, the Largest Family of Salamanders.

    Science.gov (United States)

    Shen, Xing-Xing; Liang, Dan; Chen, Meng-Yun; Mao, Rong-Li; Wake, David B; Zhang, Peng

    2016-01-01

    Deep phylogenetic relationships of the largest salamander family Plethodontidae have been difficult to resolve, probably reflecting a rapid diversification early in their evolutionary history. Here, data from 50 independent nuclear markers (total 48,582 bp) are used to reconstruct the phylogeny and divergence times for plethodontid salamanders, using both concatenation and coalescence-based species tree analyses. Our results robustly resolve the position of the enigmatic eastern North American four-toed salamander (Hemidactylium) as the sister taxon of Batrachoseps + Tribe Bolitoglossini, thus settling a long-standing question. Furthermore, we statistically reject sister taxon status of Karsenia and Hydromantes, the only plethodontids to occur outside the Americas, leading us to new biogeographic hypotheses. Contrary to previous long-standing arguments that plethodontid salamanders are an old lineage originating in the Cretaceous (more than 90 Ma), our analyses lead to the hypothesis that these salamanders are much younger, arising close to the K-T boundary (~66 Ma). These time estimates are highly stable using alternative calibration schemes and dating methods. Our data simulation highlights the potential risk of making strong arguments about phylogenetic timing based on inferences from a handful of nuclear genes, a common practice. Based on the newly obtained timetree and ancestral area reconstruction results, we argue that (i) the classic "Out of Appalachia" hypothesis of plethodontid origins is problematic; (ii) the common ancestor of extant plethodontids may have originated in northwestern North America in the early Paleocene; (iii) origins of Eurasian plethodontids likely result from two separate dispersal events from western North America via Beringia in the late Eocene (~42 Ma) and the early Miocene (~23 Ma), respectively.

  19. Healthy younger and older adults control foot placement to avoid small obstacles during gait primarily by modulating step width

    Directory of Open Access Journals (Sweden)

    Schulz Brian W

    2012-10-01

    Full Text Available Abstract Background Falls are a significant problem in the older population. Most falls occur during gait, which is primarily regulated by foot placement. Variability of foot placement has been associated with falls, but these associations are inconsistent and generally for smooth, level flooring. This study investigates the control of foot placement and the associated gait variability in younger and older men and women (N=7/group, total N=28 while walking at three different speeds (slow, preferred, and fast across a control surface with no obstacles and surfaces with multiple (64 small (10cm long ×13mm high visible and hidden obstacles. Results Minimum obstacle distance between the shoe and nearest obstacle during each footfall was greater on the visible obstacles surface for older subjects because some of them chose to actively avoid obstacles. This obstacle avoidance strategy was implemented primarily by modulating step width and to a lesser extent step length as indicated by linear regressions of step width and length variability on minimum obstacle distance. Mean gait speed, step length, step width, and step time did not significantly differ by subject group, flooring surface, or obstacle avoidance strategy. Conclusions Some healthy older subjects choose to actively avoid small obstacles that do not substantially perturb their gait by modulating step width and, to a lesser extent, step length. It is not clear if this obstacle avoidance strategy is appropriate and beneficial or overcautious and maladaptive, as it results in fewer obstacles encountered at a consequence of a less efficient gait pattern that has been shown to indicate increased fall risk. Further research is needed on the appropriateness of strategy selection when the environmental demands and/or task requirements have multiple possible completion strategies with conflicting objectives (i.e. perceived safety vs. efficiency.

  20. 22 CFR 11.11 - Mid-level Foreign Service officer career candidate appointments.

    Science.gov (United States)

    2010-04-01

    ... affirmative factor in the selection of candidates for appointment as Foreign Service officer career candidates..., experience, and skills needed by the Foreign Service at the mid-level. (3) Age. All career candidate... terminated and the candidate so informed. (10) Foreign language requirement. All candidates who pass the...