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Sample records for candidate regions influencing

  1. Career Influences of Music Education Audition Candidates

    Science.gov (United States)

    Rickels, David A.; Brewer, Wesley D.; Councill, Kimberly H.; Fredrickson, William E.; Hairston, Michelle; Perry, David L.; Porter, Ann M.; Schmidt, Margaret

    2013-01-01

    In this descriptive study, we examined the influences and experiences motivating students to enter college-level music schools as reported by a population of precollegiate students auditioning (but not yet accepted) to music education degree programs. As a follow-up to a published pilot study, this research was designed to quantify the various…

  2. Candidate Smoke Region Segmentation of Fire Video Based on Rough Set Theory

    OpenAIRE

    Yaqin Zhao

    2015-01-01

    Candidate smoke region segmentation is the key link of smoke video detection; an effective and prompt method of candidate smoke region segmentation plays a significant role in a smoke recognition system. However, the interference of heavy fog and smoke-color moving objects greatly degrades the recognition accuracy. In this paper, a novel method of candidate smoke region segmentation based on rough set theory is presented. First, Kalman filtering is used to update video background in order to ...

  3. The Influence of Corporate Image and Specificity of Candidate Qualifications on Response to Recruitment Advertisement.

    Science.gov (United States)

    Belt, John A.; Paolillo, Joseph G. P.

    1982-01-01

    Examined possible impact of corporate image and the degree of specificity of candidate qualifications, on likelihood of reader response to recruitment advertisement. Data indicated that corporate image of advertiser significantly influenced likelihood of reader response whereas degree of specificity of candidate qualifications did not influence…

  4. Candidates of Halpha emitting regions in Magellanic Stream IV cloud

    CERN Document Server

    Yagi, Masafumi; Yoshida, Michitoshi

    2012-01-01

    From H\\alpha narrow band observations, we identified three H\\alpha emitting regions in the direction of Magellanic Stream IV (MS IV). They consist of three parallel filaments with 2 arcmin width and 6 -- 30 arcmin length at 12 arcmin intervals. The mean surface brightness of them is $\\sim 2 \\times 10^{-18}$ erg s$^{-1}$ cm$^{-2}$ arcsec$^{-2}$. Because of their low surface brightness, the regions were not detected in previous H\\alpha surveys. In HI map, the position of the filaments overlap MS, suggesting that they are parts of MS, but there also exists a local HI structure. If the filaments associate with MS, the sizes are 30 pc $\\times$ 100 -- 500 pc. The filaments lie at the leading edge of a downstream cloud, which supports a shock heating and its propagation (shock cascade) model for the ionizing source. If they are local objects, on the other hand, Fossil Str\\"omgren Trails of more than two stars is a possible interpretation, and the sizes would be 0.1 pc $\\times$ 0.3 -- 1.5 pc at 180 pc distance. The p...

  5. Factors influencing Turkish teacher candidates' elective course preferences

    Directory of Open Access Journals (Sweden)

    Duygu Uçgun

    2012-10-01

    Full Text Available By the Academic Year of 2006-2007, new curriculum has been begun to be applied in the Faculties of Education. When it is evaluated in terms of Turkish Language Teacher Training Departments, it is seen that the most attractive changes are the abolition of Side Branch application, the increase in the number of the courses which will contribute to teacher candidates’ profession and the enrichment in the content. In the curriculum are 5 elective courses beside necessary ones. The aim of this study is to determine what and how much effects the Turkish Language Teacher Candidates as they decide on the courses mentioned above. In the study, based on scanning method, of which subject is consists of 2nd, 3rd and 4th year students from Turkish Language Teacher Training Department, The Faculty of Education of Nigde University Likert-type Scale with four grades which was improved by Tezcan and Gumus (2008 has been used as data collection tool. According to the finding acquired from the study the factors effecting Turkish Language Teacher Candidates’ preferences about elective courses have been determined and ideas which are going to contribute to determination of elective courses and effective process of them have been suggested.

  6. Factors influencing candidates' choice of a pediatric dental residency program.

    Science.gov (United States)

    da Fonseca, Marcio A; Pollock, Matthew; Majewski, Robert; Tootla, Ruwaida; Murdoch-Kinch, Carol Anne

    2007-09-01

    The goal of this study was to identify the factors and program characteristics that influenced the program ranking decisions of applicants to pediatric dentistry residency programs. A questionnaire was sent to the first-year resident class in 2005 with a response rate of 69.2 percent (n=260). Approximately 55 percent were female (104/180) and 61 percent were non-His-panic white (110/180). The respondents reported that they applied to an average of nine programs, of which five were ranked. Most applicants were interested in a program that had a hospital component with a duration of two years. A program's ability to prepare the resident for an academic career was a minimal influence for 48.6 percent (87/179), and 57.5 percent (103/179) were not interested in a master's or Ph.D. degree. Factors associated with program ranking included modern clinical facilities, high ratio of dental assistants and faculty to residents, availability of assistants for sedation and general anesthesia cases, availability of a salary or stipend, and amount of clinical experience. Important non-clinical factors included hospitality during the interview, geographic location, and perceived reputation of the program. Opportunity to speak with the current residents in private, observing the interaction between residents and faculty, and touring the facilities were also highly considered. These findings may help program directors tailor their interviews and programs to suit the needs of applicants. PMID:17761626

  7. Genetic effects of polymorphisms in candidate genes and the QTL region on chicken age at first egg

    Directory of Open Access Journals (Sweden)

    Zhou Min

    2011-04-01

    Full Text Available Abstract Background The age at first egg (AFE, an important indicator for sexual maturation in female chickens, is controlled by polygenes. Based on our knowledge of reproductive physiology, 6 genes including gonadotrophin releasing hormone-I (GnRH-I, neuropeptide Y (NPY, dopamine D2 receptor (DRD2, vasoactive intestinal polypeptide (VIP, VIP receptor-1 (VIPR-1, and prolactin (PRL, were selected as candidates for influencing AFE. Additionally, the region between ADL0201 and MCW0241 of chromosome Z was chosen as the candidate QTL region according to some QTL databases. The objective of the present study was to investigate the effects of mutations in candidate genes and the QTL region on chicken AFE. Results Marker-trait association analysis of 8 mutations in those 6 genes in a Chinese native population found a highly significant association (P G840327C of the GnRH-I gene with AFE, and it remained significant even with Bonferroni correction. Based on the results of the 2-tailed χ2 test, mutations T32742394C, T32742468C, G32742603A, and C33379782T in the candidate QTL region of chromosome Z were selected for marker-trait association analysis. The haplotypes of T32742394C and T32742468C were significantly associated (P T32742394C and T32742468C were located in the intron region of the SH3-domain GRB2-like 2 (SH3GL2 gene, which appeared to be associated in the endocytosis and development of the oocyte. Conclusion This study found that G840327C of the GnRH-I gene and the haplotypes of T32742394C-T32742468C of the SH3GL2 gene were associated with the chicken AFE.

  8. Candidate Smoke Region Segmentation of Fire Video Based on Rough Set Theory

    Directory of Open Access Journals (Sweden)

    Yaqin Zhao

    2015-01-01

    Full Text Available Candidate smoke region segmentation is the key link of smoke video detection; an effective and prompt method of candidate smoke region segmentation plays a significant role in a smoke recognition system. However, the interference of heavy fog and smoke-color moving objects greatly degrades the recognition accuracy. In this paper, a novel method of candidate smoke region segmentation based on rough set theory is presented. First, Kalman filtering is used to update video background in order to exclude the interference of static smoke-color objects, such as blue sky. Second, in RGB color space smoke regions are segmented by defining the upper approximation, lower approximation, and roughness of smoke-color distribution. Finally, in HSV color space small smoke regions are merged by the definition of equivalence relation so as to distinguish smoke images from heavy fog images in terms of V component value variety from center to edge of smoke region. The experimental results on smoke region segmentation demonstrated the effectiveness and usefulness of the proposed scheme.

  9. Factors Influencing Entering Teacher Candidates' Preferences for Instructional Activities: A glimpse into their orientations towards teaching

    Science.gov (United States)

    Talanquer, Vicente; Novodvorsky, Ingrid; Tomanek, Debra

    2010-07-01

    The present study was designed to identify and characterize the major factors that influence entering science teacher candidates' preferences for different types of instructional activities, and to analyze what these factors suggest about teacher candidates' orientations towards science teaching. The study involved prospective teachers enrolled in the introductory science teaching course in an undergraduate science teacher preparation program. Our analysis was based on data collected using a teaching and learning beliefs questionnaire, together with structured interviews. Our results indicate that entering science teacher candidates have strong preferences for a few activity types. The most influential factors driving entering science teacher candidates' selections were the potential of the instructional activities to motivate students, be relevant to students' personal lives, result in transfer of skills to non-science situations, actively involve students in goal-directed learning, and implement curriculum that represents what students need to know. This set of influencing factors suggests that entering science teacher candidates' orientations towards teaching are likely driven by one or more of these three central teaching goals: (1) motivating students, (2) developing science process skills, and (3) engaging students in structured science activities. These goals, and the associated beliefs about students, teaching, and learning, can be expected to favor the development or enactment of three major orientations towards teaching in this population of future science teachers: "motivating students," "process," and "activity-driven."

  10. Difference Imaging of Lensed Quasar Candidates inthe SDSS Supernova Survey Region

    Energy Technology Data Exchange (ETDEWEB)

    Lacki, Brian C.; Kochanek, Christopher S.; Stanek, Krzysztof Z.; Inada, Naohisa; Oguri, Masamune

    2008-02-04

    Difference imaging provides a new way to discover gravitationally lensed quasars because few non-lensed sources will show spatially extended, time variable flux. We test the method on lens candidates in the Sloan Digital Sky Survey (SDSS) Supernova Survey region from the SDSS Quasar Lens Search (SQLS) and their surrounding fields. Starting from 20768 sources, including 49 SDSS quasars and 36 candidate lenses/lensed images, we find that 21 sources including 15 SDSS QSOs and 7 candidate lenses/lensed images are non-periodic variable sources. We can measure the spatial structure of the variable flux for 18 of these sources and identify only one as a non-point source. This source does not display the compelling spatial structure of the variable flux of known lensed quasars, so we reject it as a lens candidate. None of the lens candidates from the SQLS survive our cuts. Given our effective survey area of order 0.71 square degrees, this indicates a false positive rate of order one per square degree for the method. The fraction of quasars not found to be variable and the false positive rate should both fall if we analyze the full, later data releases for the SDSS fields. While application of the method to the SDSS is limited by the resolution, depth, and sampling of the survey, several future surveys such as Pan-STARRS, LSST, and SNAP will avoid these limitations.

  11. Difference Imaging of Lensed Quasar Candidates in the SDSS Supernova Survey Region

    CERN Document Server

    Lacki, Brian C; Stanek, Krzysztof Z; Inada, Naohisa; Oguri, Masamune

    2008-01-01

    Difference imaging provides a new way to discover gravitationally lensed quasars because few non-lensed sources will show spatially extended, time variable flux. We test the method on lens candidates in the Sloan Digital Sky Survey (SDSS) Supernova Survey region from the SDSS Quasar Lens Search (SQLS) and their surrounding fields. Starting from 20768 sources, including 49 SDSS quasars and 36 candidate lenses/lensed images, we find that 21 sources including 15 SDSS QSOs and 7 candidate lenses/lensed images are non-periodic variable sources. We can measure the spatial structure of the variable flux for 18 of these sources and identify only one as a non-point source. This source does not display the compelling spatial structure of the variable flux of known lensed quasars, so we reject it as a lens candidate. None of the lens candidates from the SQLS survive our cuts. Given our effective survey area of order 0.71 square degrees, this indicates a false positive rate of order one per square degree for themethod. T...

  12. Transport Infrastructure Influences on the Regional Development

    OpenAIRE

    Frantz Daniel Fistung; Oana Bianca Fistung; Teodor Popescu

    2013-01-01

    The scope of this work is to analyze the influence of transport infrastructure, on regional development. Moreover, it aims to illustrate the major influences of the economic, social and ecological factors on transport infrastructure development. In that respect, starting by analyzing the current views on national and international levels regarding these items, the work propose to go further, by supplement these theories with some new elements, requested by the current and future society’s evo...

  13. DIFFERENCE IMAGING OF LENSED QUASAR CANDIDATES IN THE SLOAN DIGITAL SKY SURVEY SUPERNOVA SURVEY REGION

    International Nuclear Information System (INIS)

    Difference imaging provides a new way to discover gravitationally lensed quasars because few nonlensed sources will show spatially extended, time variable flux. We test the method on the fields of lens candidates in the Sloan Digital Sky Survey (SDSS) Supernova Survey region from the SDSS Quasar Lens Search (SQLS) and one serendipitously discovered lensed quasar. Starting from 20,536 sources, including 49 SDSS quasars, 32 candidate lenses/lensed images, and one known lensed quasar, we find that 174 sources including 35 SDSS quasars, 16 candidate lenses/lensed images, and the known lensed quasar are nonperiodic variable sources. We can measure the spatial structure of the variable flux for 119 of these variable sources and identify only eight as candidate extended variables, including the known lensed quasar. Only the known lensed quasar appears as a close pair of sources on the difference images. Inspection of the remaining seven suggests they are false positives, and only two were spectroscopically identified quasars. One of the lens candidates from the SQLS survives our cuts, but only as a single image instead of a pair. This indicates a false positive rate of order ∼1/4000 for the method, or given our effective survey area of order 0.82 deg.2, ∼5 per deg.2 in the SDSS Supernova Survey. The fraction of quasars not found to be variable and the false positive rate would both fall if we had analyzed the full, later data releases for the SDSS fields. While application of the method to the SDSS is limited by the resolution, depth, and sampling of the survey, several future surveys such as Pan-STARRS, LSST, and SNAP will significantly improve on these limitations.

  14. Difference Imaging of Lensed Quasar Candidates in the Sloan Digital Sky Survey Supernova Survey Region

    Science.gov (United States)

    Lacki, Brian C.; Kochanek, Christopher S.; Stanek, Krzysztof Z.; Inada, Naohisa; Oguri, Masamune

    2009-06-01

    Difference imaging provides a new way to discover gravitationally lensed quasars because few nonlensed sources will show spatially extended, time variable flux. We test the method on the fields of lens candidates in the Sloan Digital Sky Survey (SDSS) Supernova Survey region from the SDSS Quasar Lens Search (SQLS) and one serendipitously discovered lensed quasar. Starting from 20,536 sources, including 49 SDSS quasars, 32 candidate lenses/lensed images, and one known lensed quasar, we find that 174 sources including 35 SDSS quasars, 16 candidate lenses/lensed images, and the known lensed quasar are nonperiodic variable sources. We can measure the spatial structure of the variable flux for 119 of these variable sources and identify only eight as candidate extended variables, including the known lensed quasar. Only the known lensed quasar appears as a close pair of sources on the difference images. Inspection of the remaining seven suggests they are false positives, and only two were spectroscopically identified quasars. One of the lens candidates from the SQLS survives our cuts, but only as a single image instead of a pair. This indicates a false positive rate of order ~1/4000 for the method, or given our effective survey area of order 0.82 deg2, ~5 per deg2 in the SDSS Supernova Survey. The fraction of quasars not found to be variable and the false positive rate would both fall if we had analyzed the full, later data releases for the SDSS fields. While application of the method to the SDSS is limited by the resolution, depth, and sampling of the survey, several future surveys such as Pan-STARRS, LSST, and SNAP will significantly improve on these limitations.

  15. A novel candidate region for genetic adaptation to high altitude in Andean populations.

    Directory of Open Access Journals (Sweden)

    Guido Valverde

    Full Text Available Humans living at high altitude (≥ 2,500 meters above sea level have acquired unique abilities to survive the associated extreme environmental conditions, including hypoxia, cold temperature, limited food availability and high levels of free radicals and oxidants. Long-term inhabitants of the most elevated regions of the world have undergone extensive physiological and/or genetic changes, particularly in the regulation of respiration and circulation, when compared to lowland populations. Genome scans have identified candidate genes involved in altitude adaption in the Tibetan Plateau and the Ethiopian highlands, in contrast to populations from the Andes, which have not been as intensively investigated. In the present study, we focused on three indigenous populations from Bolivia: two groups of Andean natives, Aymara and Quechua, and the low-altitude control group of Guarani from the Gran Chaco lowlands. Using pooled samples, we identified a number of SNPs exhibiting large allele frequency differences over 900,000 genotyped SNPs. A region in chromosome 10 (within the cytogenetic bands q22.3 and q23.1 was significantly differentiated between highland and lowland groups. We resequenced ~1.5 Mb surrounding the candidate region and identified strong signals of positive selection in the highland populations. A composite of multiple signals like test localized the signal to FAM213A and a related enhancer; the product of this gene acts as an antioxidant to lower oxidative stress and may help to maintain bone mass. The results suggest that positive selection on the enhancer might increase the expression of this antioxidant, and thereby prevent oxidative damage. In addition, the most significant signal in a relative extended haplotype homozygosity analysis was localized to the SFTPD gene, which encodes a surfactant pulmonary-associated protein involved in normal respiration and innate host defense. Our study thus identifies two novel candidate genes and

  16. Computerized detection of multiple sclerosis candidate regions based on a level set method using an artificial neural network

    International Nuclear Information System (INIS)

    Yamamoto et al. developed the system for computer-aided detection of multiple sclerosis (MS) candidate regions. In a level set method in their proposed method, they employed the constant threshold value for the edge indicator function related to a speed function of the level set method. However, it would be appropriate to adjust the threshold value to each MS candidate region, because the edge magnitudes in MS candidates differ from each other. Our purpose of this study was to develop a computerized detection of MS candidate regions in MR images based on a level set method using an artificial neural network (ANN). To adjust the threshold value for the edge indicator function in the level set method to each true positive (TP) and false positive (FP) region, we constructed the ANN. The ANN could provide the suitable threshold value for each candidate region in the proposed level set method so that TP regions can be segmented and FP regions can be removed. Our proposed method detected MS regions at a sensitivity of 82.1% with 0.204 FPs per slice and similarity index of MS candidate regions was 0.717 on average. (author)

  17. Candidate region linkage analysis in twins discordant or concordant for depression symptomatology

    DEFF Research Database (Denmark)

    Christiansen, Lene; Tan, Q; Kruse, T A; McGue, M; Christensen, Kaare

    common susceptibility locus in affective disorders on chromosome 12q24. In this study we investigated the chromosome 12 candidate region for linkage to the mean level of depression symptomatology, over a 10-year follow-up, using a highly informative sample of concordant and discordant twin pairs selected......Genetic risk factors contribute considerably to both clinical affective disorders and subsyndromal mood level. There is moreover evidence to suggest that the genetic basis of bipolar disorder and unipolar depression overlap to some extent, and several linkage analyses have suggested evidence for a...

  18. A Test of Seven Candidate Barcode Regions from the Plastome in Picea (Pinaceae)

    Institute of Scientific and Technical Information of China (English)

    Jin-Hua Ran; Pei-Pei Wang; Hui-Juan Zhao; Xiao-Quan Wang

    2010-01-01

    DNA barcoding, as a tool for species discrimination, has been used efficiently in animals, algae and fungi, but there are still debates on which DNA region(s) can be used as the standard barcode(s) for land plants. Gymnosperms, especially conifers, are important components of forests, and there is an urgent need for them to be identified through DNA barcoding because of their high frequency of collection in the field. However, the feasibility of DNA barcoding in gymnosperms has not been examined based on a dense species sampling. Here we selected seven candidate DNA barcodes from the plastome (matK, rbcL, rpoB, rpoC1, atpF-atpH, psbA-trnH, and psbK-psbl) to evaluate their suitability in Picea (spruce). The results showed that none of them or their different combinations has sufficient resolution for spruce species, although matK+rbcL might be used as a two-locus barcode. The low efficiency of these candidate barcodes in Picea might be caused by the paternal inheritance of the chloroplast genome, long generation time, recent radiation, and frequent inter-specific hybridization aided by wind pollination. Some of these factors could also be responsible for the difficulties in barcoding other plant groups. Furthermore, the potential of the nuclear LEAFY gene as a land plant barcode was discussed.

  19. Basic Criteria for the Success of the Electoral Candidates and their Influence on Voters’ Selection Decision

    Directory of Open Access Journals (Sweden)

    Mahmod Jasim Alsamydai

    2013-05-01

    Full Text Available This study is designed to clarify the integral component and criteria of the success of the electoral candidate and its impact on the voters' selection decision (a case study of Jordanian voters. For the purpose of identifying the most important basic components that influence voters choice decision, the study's model was designed based on these criteria taking into consideration previous studies related to political and electoral marketing and extant political science research as well as the nature of the Jordanian environment. The model study was divided into five major dimensions which are (candidates’ personal attributes, political background, candidates’ credibility, communications and contact means used by the candidates and campaign management and how they influence voters’ selection decision. In addition, a hypothesis was developed for each dimension as well as another hypothesis was proposed in order to measure the significance of the relationship between the different components of the study’s model. In order to collect the data required for examining the hypotheses and drawing conclusions, a questionnaire consisting of (24 questions covering the dimensions and the hypotheses of the study, was designed. The design and development of this questionnaire was based on an initial pre-tested survey distributed to a sample consisting of ( 60 individuals who are eligible to participate in the Jordanian election. The initial survey was also pre-tested and evaluated by a panel of experts in marketing and politic specialists in order to assess the items within each construct. The questionnaire was then distributed to Jordanian citizens in Amman. Data collection resulted in (629 usable surveys for subsequent analysis. Certain statistical methods were adopted in data analysis and reaching results. The resulted of statistical analysis indicated acceptance of all hypotheses relating to the impact of the ingredients (Standards included in the

  20. Characterisation of five candidate genes within the ETEC F4ab/ac candidate region in pigs

    DEFF Research Database (Denmark)

    Jacobsen, Mette Juul; Cirera Salicio, Susanna; Joller, David;

    2011-01-01

    dominant Mendelian trait. Indentifying the genetics behind this trait will greatly benefit pig welfare as well as the pig breeding industry by providing an opportunity to select against genetically susceptible animals, thereby reducing the number of diarrhoea outbreaks. The trait has recently been mapped...... between ETEC F4ab/ac resistant and ETEC F4ab/ac susceptible animals in any of the tested tissues. CONCLUSIONS: None of the identified polymorphisms are obvious causative mutations for ETEC F4ab/ac susceptibility, as they have no impact on the level of the overall mRNA expression nor predicted to influence...

  1. Influences to post-graduation career aspirations and attainment in STEM doctoral candidates and recipients

    Science.gov (United States)

    Barry, Deborah S.

    As the realities of the academic job market have forced some PhD recipients to accept less-preferable position types, there has been increasing concerns that these students are not prepared for their careers, especially in STEM fields. However, aside from the labor market, few studies have explored the influences on career aspiration and attainment among doctoral degree holders. This study utilized the socialization theory framework to identify aspects of the doctoral education process that are predictive of the likelihood of certain career aspirations among science and engineering doctoral candidates and career attainment among STEM doctoral recipients by utilizing nationally representative datasets: The National Research Council's Assessment of Research Doctorate Programs student questionnaire and the National Science Foundation's Survey of Earned Doctorates. This study identified field of study, research productivity rank of doctoral programs, primary type of finding doctoral students received, level of satisfaction with research experiences, and their sense of belonging within their doctoral program as factors that predict the likelihood of certain career aspirations compared with a career in education. Doctoral candidates' background characteristics that were significant predictors of career aspirations were gender, marital status, dependent status, race, age, and citizenship status. Further, this study identified participant's field of study, the Carnegie Rank of institutions attended, primary type of funding received, length of time to PhD, gender, marital status, dependent status, race, citizenship stats, and age as factors that predict the likelihood of the career outcomes investigated in this study, including doctoral recipients' employment field and primary work activity.

  2. The influence of social networking web sites on the evaluation of job candidates.

    Science.gov (United States)

    Bohnert, Daniel; Ross, William H

    2010-06-01

    This study investigated how the content of social networking Web site (SNW) pages influenced others' evaluation of job candidates. Students (N = 148) evaluated the suitability of hypothetical candidates for an entry-level managerial job. A 2 x 4 design was employed: résumés were either marginally qualified or well qualified for the job. SNW printouts reflected (a) an emphasis on drinking alcohol, (b) a family orientation, or (c) a professional orientation; participants in a control group received no Web page information. In addition to a main effect for résumé quality, applicants with either a family-oriented or a professional-oriented SNW were seen as more suitable for the job and more conscientious than applicants with alcohol-oriented SNW pages. They were more likely to be interviewed. If hired, they were also likely to be offered significantly higher starting salaries. Results are discussed in terms of implications for both managers and applicants. PMID:20557256

  3. Candidate Gene Discovery Procedure after Follow-Up Confirmatory Analyses of Candidate Regions of Interests for Alzheimer’s Disease in the NIMH Sibling Dataset

    Directory of Open Access Journals (Sweden)

    Tesfaye M. Baye

    2008-01-01

    Full Text Available The objective of this research was to develop a procedure to identify candidate genes under linkage peaks confirmed in a follow-up of candidate regions of interests (CRIs identified in our original genome scan in the NIMH Alzheimer’s diseases (AD Initiative families (Blacker et al. [1]. There were six CRIs identified that met the threshold of multipoint lod score (MLS of ≥ 2.0 from the original scan. The most significant peak (MLS = 7.7 was at 19q13, which was attributed to APOE. The remaining CRIs with ‘suggestive’ evidence for linkage were identified at 9q22, 6q27, 14q22, 11q25, and 3p26. We have followed up and narrowed the 9q22 CRI signal using simple tandem repeat (STR markers (Perry et al. [2]. In this confirmatory project, we have followed up the 6q27, 14q22, 11q25, and 3p26 CRIs with a total of 24 additional flanking STRs, reducing the mean interval marker distance (MID in each CRI, and substantially increase in the information content (IC. The linkage signals at 6q27, 14q22 and 11q25 remain ‘suggestive’, indicating that these CRIs are promising and worthy of detailed fine mapping and assessment of candidate genes associated with AD.

  4. Novel candidate genes AuxRP and Hsp90 influence the chip color of potato tubers

    OpenAIRE

    Sołtys-Kalina, Dorota; Szajko, Katarzyna; Sierocka, Izabela; Śliwka, Jadwiga; Strzelczyk-Żyta, Danuta; Wasilewicz-Flis, Iwona; Jakuczun, Henryka; Szweykowska-Kulinska, Zofia; Marczewski, Waldemar

    2015-01-01

    Potato (Solanum tuberosum L.) tubers exhibit significant variation in reducing sugar content directly after harvest, cold storage and reconditioning. Here, we performed QTL analysis for chip color, which is strongly influenced by reducing sugar content, in a diploid potato mapping population. Two QTL on chromosomes I and VI were detected for chip color after harvest and reconditioning. Only one region on chromosome VI was linked with cold-induced sweetening. Using the RT-PCR technique, we sho...

  5. Novel approach of crater detection by crater candidate region selection and matrix-pattern-oriented least squares support vector machine

    Institute of Scientific and Technical Information of China (English)

    Ding Meng; Cao Yunfeng; Wu Qingxian

    2013-01-01

    Impacted craters are commonly found on the surface of planets,satellites,asteroids and other solar system bodies.In order to speed up the rate of constructing the database of craters,it is important to develop crater detection algorithms.This paper presents a novel approach to automatically detect craters on planetary surfaces.The approach contains two parts:crater candidate region selection and crater detection.In the first part,crater candidate region selection is achieved by Kanade-Lucas-Tomasi (KLT) detector.Matrix-pattern-oriented least squares support vector machine (MatLSSVM),as the matrixization version of least square support vector machine (SVM),inherits the advantages of least squares support vector machine (LSSVM),reduces storage space greatly and reserves spatial redundancies within each image matrix compared with general LSSVM.The second part of the approach employs MatLSSVM to design classifier for crater detection.Experimental results on the dataset which comprises 160 preprocessed image patches from Google Mars demonstrate that the accuracy rate of crater detection can be up to 88%.In addition,the outstanding feature of the approach introduced in this paper is that it takes resized crater candidate region as input pattern directly to finish crater detection.The results of the last experiment demonstrate that MatLSSVM-based classifier can detect crater regions effectively on the basis of KLT-based crater candidate region selection.

  6. Isolation of candidate genes and physical mapping in the Familial Dysautonomia region of chromosome 9q31

    Energy Technology Data Exchange (ETDEWEB)

    Slaugenhaupt, S.A.; Liebert, C.B.; Monahan, M. [Harvard Medical School, Boston, MA (United States)] [and others

    1994-09-01

    Familial Dysautonomia is an autosomal recessive disorder characterized by the developmental loss of both sensory and autonomic neurons. We have mapped the DYS gene to human chromosome 9q31-33 by genetic linkage analysis of 26 Ashkenazi Jewish pedigrees. The gene is located in a 3 cM interval between D9S310 and D9S105. We have examined several new SSCP and repeat polymorphisms and have successfully narrowed the minimum candidate region to approximately 300 kb using linkage disequilibrium. A YAC contig that spans 1.5 Mb has been constructed using both Alu-PCR and STS screening methods. In addition, the YACs were used to isolate cosmids by direct hybridization to the Lawrence Livermore National Laboratory chromosome 9 flow-sorted cosmid library. Having cloned the minimal candidate region, we are now constructing a detailed transcription map of the DYS region of chromosome 9. Using exon amplification, we have rapidly identified exon sequences and have used these as probes to isolate three candidate genes. These genes are currently being sequenced and will be assessed for mutations using both SSCP analysis and direct sequencing. A detailed physical map of the DYS region, as well as sequence and homology information for DYS candidate genes, will be presented.

  7. Application of pooled genotyping to scan candidate regions for association with HDL cholesterol levels

    Directory of Open Access Journals (Sweden)

    Hinds David A

    2004-11-01

    Full Text Available Abstract Association studies are used to identify genetic determinants of complex human traits of medical interest. With the large number of validated single nucleotide polymorphisms (SNPs currently available, two limiting factors in association studies are genotyping capability and costs. Pooled DNA genotyping has been proposed as an efficient means of screening SNPs for allele frequency differences in case-control studies and for prioritising them for subsequent individual genotyping analysis. Here, we apply quantitative pooled genotyping followed by individual genotyping and replication to identify associations with human serum high-density lipoprotein (HDL cholesterol levels. The DNA from individuals with low and high HDL cholesterol levels was pooled separately, each pool was amplified by polymerase chain reaction in triplicate and each amplified product was separately hybridised to a high-density oligonucleotide array. Allele frequency differences between case and control groups with low and high HDL cholesterol levels were estimated for 7,283 SNPs distributed across 71 candidate gene regions spanning a total of 17.1 megabases. A novel method was developed to take advantage of independently derived haplotype map information to improve the pooled estimates of allele frequency differences. A subset of SNPs with the largest estimated allele frequency differences between low and high HDL cholesterol groups was chosen for individual genotyping in the study population, as well as in a separate replication population. Four SNPs in a single haplotype block within the cholesteryl ester transfer protein (CETP gene interval were significantly associated with HDL cholesterol levels in both populations. Our study is among the first to demonstrate the application of pooled genotyping followed by confirmation with individual genotyping to identify genetic determinants of a complex trait.

  8. Mitochondrial DNA variant at HVI region as a candidate of genetic markers of type 2 diabetes

    Science.gov (United States)

    Gumilar, Gun Gun; Purnamasari, Yunita; Setiadi, Rahmat

    2016-02-01

    Mitochondrial DNA (mtDNA) is maternally inherited. mtDNA mutations which can contribute to the excess of maternal inheritance of type 2 diabetes. Due to the high mutation rate, one of the areas in the mtDNA that is often associated with the disease is the hypervariable region I (HVI). Therefore, this study was conducted to determine the genetic variants of human mtDNA HVI that related to the type 2 diabetes in four samples that were taken from four generations in one lineage. Steps being taken include the lyses of hair follicles, amplification of mtDNA HVI fragment using Polymerase Chain Reaction (PCR), detection of PCR products through agarose gel electrophoresis technique, the measurement of the concentration of mtDNA using UV-Vis spectrophotometer, determination of the nucleotide sequence via direct sequencing method and analysis of the sequencing results using SeqMan DNASTAR program. Based on the comparison between nucleotide sequence of samples and revised Cambridge Reference Sequence (rCRS) obtained six same mutations that these are C16147T, T16189C, C16193del, T16127C, A16235G, and A16293C. After comparing the data obtained to the secondary data from Mitomap and NCBI, it were found that two mutations, T16189C and T16217C, become candidates as genetic markers of type 2 diabetes even the mutations were found also in the generations of undiagnosed type 2 diabetes. The results of this study are expected to give contribution to the collection of human mtDNA database of genetic variants that associated to metabolic diseases, so that in the future it can be utilized in various fields, especially in medicine.

  9. INFLUENCE OF AUTOMOTIVE CLUSTERS IN REGIONAL DEVELOPMENT

    OpenAIRE

    Constantin BORDEI

    2014-01-01

    This paper proposes an overview of the evolution in the automotive sector in the process of regional development. The fundamental changes made by the component supplier sector improved the regional development and manufacturing process. Automotive industry is one of the modern sectors in many countries that benefits of a high technology impact and creates jobs that reduces unemployment across Europe. The auto industry changed cities, regions and countries into poles of development and it beco...

  10. Solar influence on global and regional climates

    OpenAIRE

    Lockwood, Mike

    2012-01-01

    The literature relevant to how solar variability influences climate is vast—but much has been based on inadequate statistics and non-robust procedures. The common pitfalls are outlined in this review. The best estimates of the solar influence on the global mean air surface temperature show relatively small effects, compared with the response to anthropogenic changes (and broadly in line with their respective radiative forcings). However, the situation is more interesting when o...

  11. Prioritization of candidate genes in “QTL-hotspot” region for drought tolerance in chickpea (Cicer arietinum L.)

    Science.gov (United States)

    Kale, Sandip M; Jaganathan, Deepa; Ruperao, Pradeep; Chen, Charles; Punna, Ramu; Kudapa, Himabindu; Thudi, Mahendar; Roorkiwal, Manish; Katta, Mohan AVSK; Doddamani, Dadakhalandar; Garg, Vanika; Kishor, P B Kavi; Gaur, Pooran M; Nguyen, Henry T; Batley, Jacqueline; Edwards, David; Sutton, Tim; Varshney, Rajeev K

    2015-01-01

    A combination of two approaches, namely QTL analysis and gene enrichment analysis were used to identify candidate genes in the “QTL-hotspot” region for drought tolerance present on the Ca4 pseudomolecule in chickpea. In the first approach, a high-density bin map was developed using 53,223 single nucleotide polymorphisms (SNPs) identified in the recombinant inbred line (RIL) population of ICC 4958 (drought tolerant) and ICC 1882 (drought sensitive) cross. QTL analysis using recombination bins as markers along with the phenotyping data for 17 drought tolerance related traits obtained over 1–5 seasons and 1–5 locations split the “QTL-hotspot” region into two subregions namely “QTL-hotspot_a” (15 genes) and “QTL-hotspot_b” (11 genes). In the second approach, gene enrichment analysis using significant marker trait associations based on SNPs from the Ca4 pseudomolecule with the above mentioned phenotyping data, and the candidate genes from the refined “QTL-hotspot” region showed enrichment for 23 genes. Twelve genes were found common in both approaches. Functional validation using quantitative real-time PCR (qRT-PCR) indicated four promising candidate genes having functional implications on the effect of “QTL-hotspot” for drought tolerance in chickpea. PMID:26478518

  12. NEW YOUNG STAR CANDIDATES IN THE TAURUS-AURIGA REGION AS SELECTED FROM THE WIDE-FIELD INFRARED SURVEY EXPLORER

    International Nuclear Information System (INIS)

    The Taurus Molecular Cloud subtends a large solid angle on the sky, in excess of 250 deg2. The search for legitimate Taurus members to date has been limited by sky coverage as well as the challenge of distinguishing members from field interlopers. The Wide-field Infrared Survey Explorer has recently observed the entire sky, and we take advantage of the opportunity to search for young stellar object (YSO) candidate Taurus members from a ∼260 deg2 region designed to encompass previously identified Taurus members. We use near- and mid-infrared colors to select objects with apparent infrared excesses and incorporate other catalogs of ancillary data to present a list of rediscovered Taurus YSOs with infrared excesses (taken to be due to circumstellar disks), a list of rejected YSO candidates (largely galaxies), and a list of 94 surviving candidate new YSO-like Taurus members. There is likely to be contamination lingering in this candidate list, and follow-up spectra are warranted.

  13. Vote Choice, Ideology, and Social Dominance Orientation Influence Preferences for Lower Pitched Voices in Political Candidates

    DEFF Research Database (Denmark)

    Laustsen, Lasse; Petersen, Michael Bang; A. Klofstad, Casey

    2015-01-01

    upon these findings by demonstrating that conservatives and Republicans tend to view the world as much more competitive and threatening than liberals and Democrats. We utilize two existing data sources to show that political candidates with lower-pitched voices are preferred more among conservative...... Republicans than among liberal Democrats. In a third study we show that preferences for lower-pitched candidate voices stem from individual differences in Social Dominance Orientation (SDO). Importantly, across all three studies subjects’ party affiliation, ideology, and SDO only predict references for male...... candidate voices. We conclude with a discussion of the results in relation to followership psychology and general debates on the rationality of the public with respect to elections....

  14. Re-sequencing data for refining candidate genes and polymorphisms in QTL regions affecting adiposity in chicken.

    Directory of Open Access Journals (Sweden)

    Pierre-François Roux

    Full Text Available In this study, we propose an approach aiming at fine-mapping adiposity QTL in chicken, integrating whole genome re-sequencing data. First, two QTL regions for adiposity were identified by performing a classical linkage analysis on 1362 offspring in 11 sire families obtained by crossing two meat-type chicken lines divergently selected for abdominal fat weight. Those regions, located on chromosome 7 and 19, contained a total of 77 and 84 genes, respectively. Then, SNPs and indels in these regions were identified by re-sequencing sires. Considering issues related to polymorphism annotations for regulatory regions, we focused on the 120 and 104 polymorphisms having an impact on protein sequence, and located in coding regions of 35 and 42 genes situated in the two QTL regions. Subsequently, a filter was applied on SNPs considering their potential impact on the protein function based on conservation criteria. For the two regions, we identified 42 and 34 functional polymorphisms carried by 18 and 24 genes, and likely to deeply impact protein, including 3 coding indels and 4 nonsense SNPs. Finally, using gene functional annotation, a short list of 17 and 4 polymorphisms in 6 and 4 functional genes has been defined. Even if we cannot exclude that the causal polymorphisms may be located in regulatory regions, this strategy gives a complete overview of the candidate polymorphisms in coding regions and prioritize them on conservation- and functional-based arguments.

  15. The Influence of Internet for Regional Economy Development

    Institute of Scientific and Technical Information of China (English)

    孟昭霞

    2011-01-01

    Internet is a kind of new technology that has exerted a tremendous influence in the all world since the late stage of the 20th. It has per- meated the all domain of the society and it has changed each field of the world. The paper probes into the theory from influencing angle of internet for regional economy, and it analyses the promoting function of network for regional economy development. It either reflects the times characteristic on regional economy research or affords a new thinking for regional economy research that the research about the relation of internet for regional economy development research.

  16. Candidate glutamatergic and dopaminergic pathway gene variants do not influence Huntington’s disease motor onset

    OpenAIRE

    Ramos, Eliana Marisa; Latourelle, Jeanne C.; Gillis, Tammy; Mysore, Jayalakshmi S.; Squitieri, Ferdinando; Di Pardo, Alba; Di Donato, Stefano; Gellera, Cinzia; Hayden, Michael R.; Morrison, Patrick J.; Nance, Martha; Ross, Christopher A.; Margolis, Russell L.; Gomez-Tortosa, Estrella; Ayuso, Carmen

    2013-01-01

    Huntington’s disease (HD) is a neurodegenerative disorder characterized by motor, cognitive, and behavioral disturbances. It is caused by the expansion of the HTT CAG repeat, which is the major determinant of age at onset (AO) of motor symptoms. Aberrant function of N-methyl-D-aspartate receptors and/or overexposure to dopamine has been suggested to cause significant neurotoxicity, contributing to HD pathogenesis. We used genetic association analysis in 1,628 HD patients to evaluate candidate...

  17. Self-Confirmation and Ascertainment of the Candidate Genomic Regions of Complex Trait Loci - A None-Experimental Solution.

    Directory of Open Access Journals (Sweden)

    Lishi Wang

    Full Text Available Over the past half century, thousands of quantitative trait loci (QTL have been identified by using animal models and plant populations. However, the none-reliability and imprecision of the genomic regions of these loci have remained the major hurdle for the identification of the causal genes for the correspondent traits. We used a none-experimental strategy of strain number reduction for testing accuracy and ascertainment of the candidate region for QTL. We tested the strategy in over 400 analyses with data from 47 studies. These studies include: 1 studies with recombinant inbred (RI strains of mice. We first tested two previously mapped QTL with well-defined genomic regions; We then tested additional four studies with known QTL regions; and finally we examined the reliability of QTL in 38 sets of data which are produced from relatively large numbers of RI strains, derived from C57BL/6J (B6 X DBA/2J (D2, known as BXD RI mouse strains; 2 studies with RI strains of rats and plants; and 3 studies using F2 populations in mice, rats and plants. In these cases, our method identified the reliability of mapped QTL and localized the candidate genes into the defined genomic regions. Our data also suggests that LRS score produced by permutation tests does not necessarily confirm the reliability of the QTL. Number of strains are not the reliable indicators for the accuracy of QTL either. Our strategy determines the reliability and accuracy of the genomic region of a QTL without any additional experimental study such as congenic breeding.

  18. Self-Confirmation and Ascertainment of the Candidate Genomic Regions of Complex Trait Loci - A None-Experimental Solution.

    Science.gov (United States)

    Wang, Lishi; Jiao, Yan; Wang, Yongjun; Zhang, Mengchen; Gu, Weikuan

    2016-01-01

    Over the past half century, thousands of quantitative trait loci (QTL) have been identified by using animal models and plant populations. However, the none-reliability and imprecision of the genomic regions of these loci have remained the major hurdle for the identification of the causal genes for the correspondent traits. We used a none-experimental strategy of strain number reduction for testing accuracy and ascertainment of the candidate region for QTL. We tested the strategy in over 400 analyses with data from 47 studies. These studies include: 1) studies with recombinant inbred (RI) strains of mice. We first tested two previously mapped QTL with well-defined genomic regions; We then tested additional four studies with known QTL regions; and finally we examined the reliability of QTL in 38 sets of data which are produced from relatively large numbers of RI strains, derived from C57BL/6J (B6) X DBA/2J (D2), known as BXD RI mouse strains; 2) studies with RI strains of rats and plants; and 3) studies using F2 populations in mice, rats and plants. In these cases, our method identified the reliability of mapped QTL and localized the candidate genes into the defined genomic regions. Our data also suggests that LRS score produced by permutation tests does not necessarily confirm the reliability of the QTL. Number of strains are not the reliable indicators for the accuracy of QTL either. Our strategy determines the reliability and accuracy of the genomic region of a QTL without any additional experimental study such as congenic breeding. PMID:27203862

  19. Self-Confirmation and Ascertainment of the Candidate Genomic Regions of Complex Trait Loci – A None-Experimental Solution

    Science.gov (United States)

    Wang, Lishi; Jiao, Yan; Wang, Yongjun; Zhang, Mengchen; Gu, Weikuan

    2016-01-01

    Over the past half century, thousands of quantitative trait loci (QTL) have been identified by using animal models and plant populations. However, the none-reliability and imprecision of the genomic regions of these loci have remained the major hurdle for the identification of the causal genes for the correspondent traits. We used a none-experimental strategy of strain number reduction for testing accuracy and ascertainment of the candidate region for QTL. We tested the strategy in over 400 analyses with data from 47 studies. These studies include: 1) studies with recombinant inbred (RI) strains of mice. We first tested two previously mapped QTL with well-defined genomic regions; We then tested additional four studies with known QTL regions; and finally we examined the reliability of QTL in 38 sets of data which are produced from relatively large numbers of RI strains, derived from C57BL/6J (B6) X DBA/2J (D2), known as BXD RI mouse strains; 2) studies with RI strains of rats and plants; and 3) studies using F2 populations in mice, rats and plants. In these cases, our method identified the reliability of mapped QTL and localized the candidate genes into the defined genomic regions. Our data also suggests that LRS score produced by permutation tests does not necessarily confirm the reliability of the QTL. Number of strains are not the reliable indicators for the accuracy of QTL either. Our strategy determines the reliability and accuracy of the genomic region of a QTL without any additional experimental study such as congenic breeding. PMID:27203862

  20. VLA observations of NGC 247: identification of compact radio sources including three candidate UD H II regions

    International Nuclear Information System (INIS)

    A high resolution, Very Large Array continuum survey of NGC 247 was undertaken in order to identify compact thermal and nonthermal radio sources, such as supernova remnants (SNRs) and H II regions. NGC 247 was observed at two frequencies, 20 cm and 6 cm, in order to calculate the spectral index, and the survey resulted in the identification of 19 compact radio sources. Using the spectral index to discriminate between source types, we identify two candidate SNRs and one H II region. Three of the radio sources have inverted spectra, indicative of ultradense H II (UD H II) regions, the short-lived, dense cores where massive stars form. Four of the sources are thermal in origin, but were not detected at 20 cm, so they could be H II regions or UD H II regions. The rest of the sources are nonthermal or undetermined. We compare the radio images with Hα, V band, and infrared archive images to look for correspondences that confirm that the sources reside in NGC 247 and are not background sources. We find that over two-thirds of the radio sources have counterparts in the Hα or V band images and are associated with NGC 247. The most luminous radio source in NGC 247 is a candidate SNR, and if confirmed as an SNR, it would be a very luminous extragalactic SNR. The H II regions and UD H II regions are calculated to have ionizing luminosities of between 4-10 × 1050 s–1; each individual source would require between 41-100 O7.5V stars to produce the corresponding ionizing luminosity. The ionizing luminosity of the UD H II regions indicates that these UD H II regions represent the lower luminosity population of the known UD H II regions and thus, they may represent a more typical population of UD H II regions that can be found and studied in the nearby galaxies as opposed to more extreme examples that have been found previously.

  1. Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer

    DEFF Research Database (Denmark)

    Quaye, Lydia; Tyrer, Jonathan; Ramus, Susan J;

    2009-01-01

    date, we have genotyped 340 SNPs from 94 candidate genes or regions, in up to 1,491 invasive epithelial ovarian cancer cases and 3,145 unaffected controls from three different population based studies from the UK, Denmark and USA. RESULTS: After adjusting for population stratification by genomic...... population stratification) P-trend = 0.006). We did not find statistically significant associations when the combined data for all SNPs were analysed using an admixture maximum likelihood (AML) experiment-wise test for association (P-heterogeneity = 0.051; P-trend = 0.068). CONCLUSION: These data suggest...

  2. A linkage study of schizophrenia candidate regions in a Chinese multiplex pedigree

    Institute of Scientific and Technical Information of China (English)

    唐劲松

    2006-01-01

    Objective This study is to explore the molecular ge- netic relationship between chromosome regions and susceptibility genes for familial schizophrenia in Chinese Hah population. Methods A multiplex schizophrenia family including 5 schizophrenia patients and their 21 relatives was included. The patients fulfilled the Diagnostic and Statistical Manual of Mental Disorders 4th Edi-

  3. Candidate regions for Waardenburg syndrome type II: Search for a second WS locus

    Energy Technology Data Exchange (ETDEWEB)

    Nance, W.E.; Pandya, A.; Blanton, S.H. [VA Commonwealth Univ, Richmond, VA (United States)] [and others

    1994-09-01

    Waardenburg syndrome is an autosomal dominant disorder characterized by deafness and pigmentary abnormalities such as heterochromia of irides, hypopigmented skin patches, white forlock and premature graying. Clinically the syndrome has been classified into three types. Type II differs from type I in that dystopia canthorum is generally absent, and type III has associated limb anomalies. Recently linkage analysis localized the gene for WSI to chromosome 2q. PAX-3, which is a human analogue of the murine pax-3 locus, maps to this region and mutations in this gene have been found to segregate with WSI. However genetic heterogeneity clearly exists: most if not all WSII families are unlinked to PAX-3 while most if not all WSI cases are linked. We ascertained a four-year-old female child with an interstitial deletion of chromosome 13 who had features of WS including bilateral congenital sensorineural hearing loss, pale blue irides and pinched nostrils as well as hypertelorism microcephaly, bilateral eyelid ptosis, digitalization of thumbs and fifth finger clinodactyly. High resolution chromosomal analysis revealed a de novo interstitial deletion of 13q22-33.2. There was no family history of WS or retardation. A similar deletion in the region of 13q21-32 has been described in a 13-year-old boy with features of WSII. These two cases strongly suggested that this chromosomal region may include a second locus for WS. We have identified eight families with clinical features of WS type I which have been excluded from linkage to the PAX-3 locus. We have typed these families for microsatellite markers spanning chromosome 13. Linkage between WSII and the chromosome 13 markers was excluded in these families. Hirschsprung disease has been associated with WS and it has recently been mapped to chromosome 10q11.2-q21.1. We are currently typing the 8 families for microsatellites in this region.

  4. CO emission from candidate photo-dissociation regions in M81

    CERN Document Server

    Knapen, J H; Heaton, H I; Kuno, N; Nakai, N

    2006-01-01

    Context At least a fraction of the atomic hydrogen in spiral galaxies is suspected to be the result of molecular hydrogen which has been dissociated by radiation from massive stars. Aims In this paper, we extend our earlier set of data from a small region of the Western spiral arm of M81 with CO observations in order to study the interplay between the radiation field and the molecular and atomic hydrogen. Methods We report CO(1-0) observations with the Nobeyama 45 m dish and the Owens Valley interferometer array of selected regions in the Western spiral arm of M81. Results From our Nobeyama data, we detect CO(1-0) emission at several locations, coinciding spatially with HI features near a far-UV source. The levels and widths of the detected CO profiles are consistent with the CO(1-0) emission that can be expected from several large photo-dissociation regions with typical sizes of some 50x150 pc located within our telescope beam. We do not detect emission at other pointings, even though several of those are ne...

  5. YAC and cosmid contigs encompassing the Fukuyama-type congenital muscular dystrophy (FCMD) candidate region on 9q31

    Energy Technology Data Exchange (ETDEWEB)

    Miyake, Masashi; Nakahori, Yutaka; Matsushita, Ikumi [Univ. of Tokyo (Japan)] [and others

    1997-03-01

    Fukuyama-type congenital muscular dystrophy (FCMD), the second most common form of childhood muscular dystrophy in Japan, is an autosomal recessive severe muscular dystrophy associated with an anomaly of the brain. We had mapped the FCMD gene to an approximately 5-cM interval between D9S127 and D9S2111 on 9q31-q33 and had also found evidence for linkage disequilibrium between FCMD and D9S306 in this candidate region. Through further analysis, we have defined another marker, D9S172, which showed stronger linkage disequilibrium than D9S306. A yeast artificial chromosome (YAC) contig spanning 3.5 Mb, which includes this D9S306-D9S172 interval on 9q31, has been constructed by a combination of sequence-tagged site, Alu-PCR, and restriction mapping. Also, cosmid clones subcloned from the YAC were assembled into three contigs, one of which contains D9S2107, which showed the strongest linkage disequilibrium with FCMD. These contigs also allowed us to order the markers as follows: cen-D9S127-({approximately}800 kb)-D9S306 (identical to D9S53)-({approximately}700 kb)-A107XF9-({approximately}500 kb)-D9S172-({approximately}30 kb)-D9S299 (identical to D9S774)-({approximately}120 kb)-WI2269-tel. Thus, we have constructed the first high-resolution physical map of the FCMD candidate region. The YAC and cosmid contigs established here will be a crucial resource for identification of the FCMD gene and other genes in this region. 37 refs., 7 figs., 2 tabs.

  6. How do Regional Headquarters Influence Corporate Decisions in Networked MNCs?

    DEFF Research Database (Denmark)

    Mahnke, Volker; Ambos, Björn; Nell, Phillip Christopher;

    2012-01-01

    as a bridge between local subsidiaries and global corporate headquarters. This paper builds theory on the antecedents to regional headquarters' influence on corporate decisions (i.e., organizational, behavioral, and motivational). Based on a survey of regional headquarters in Europe and their......In networked MNCs where knowledge and power are distributed, corporate strategy processes benefit from input arising from many different levels of the organization. Recently, the regional (i.e., supra-national) level has been emphasized as an important additional source of knowledge and input, and...... relations with MNC headquarters, we provide empirical evidence that a regional headquarters' autonomy and signaling behavior have significant effects on its influence on corporate strategy. Furthermore, we find support for our hypothesis that the regional headquarters' charter moderates such bottom...

  7. Genetic Influence of Candidate Osteoporosis Genes in Saudi Arabian Population: A Pilot Study

    Directory of Open Access Journals (Sweden)

    Mir Sadat-Ali

    2012-01-01

    Full Text Available Background and Objectives. The purpose of the present study is to find the genes and SNP that influence BMD and postmenopausal Saudi women. Material and Methods. Two-hundred ethnic Saudi Arabian women with a diagnosis of postmenopausal osteoporosis were the subjects of this study. Baseline blood hematology, biochemistry, and bone panel were done. Blood was collected, and three TaqMan-MGB probes were used to analyze SNP variants in ALOX15 (rs7220870, LRP5 (C 25752205 10, and TNFRSF11B (C 11869235 10. Results. The variant of ALOX15 17p13 showed that the BMD of the spine was lower in the AA allele (P value <0.002 and fractures were highest at 50% compared to CC allele. In the TNFRSF11B gene, BMD of the hip and spine was significantly higher in the GG allele and the history of fractures was significantly higher in GG group. With regard to the LRP5 (C 25752205 10 gene, there was no significant difference between allele groups. Conclusion(s. This study shows that the genetic influence of osteoporosis in the Caucasian and Saudi Arabians population is similar. We believe that the same genetic markers that influence osteoporosis in the Caucasian race could be used for further studies in the Saudi Arabian population.

  8. Predicted Coverage and Immuno-Safety of a Recombinant C-Repeat Region Based Streptococcus pyogenes Vaccine Candidate.

    Science.gov (United States)

    McNeilly, Celia; Cosh, Samantha; Vu, Therese; Nichols, Jemma; Henningham, Anna; Hofmann, Andreas; Fane, Anne; Smeesters, Pierre R; Rush, Catherine M; Hafner, Louise M; Ketheesan, Natkuman; Sriprakash, Kadaba S; McMillan, David J

    2016-01-01

    The C-terminal region of the M-protein of Streptococcus pyogenes is a major target for vaccine development. The major feature is the C-repeat region, consisting of 35-42 amino acid repeat units that display high but not perfect identity. SV1 is a S. pyogenes vaccine candidate that incorporates five 14mer amino acid sequences (called J14i variants) from differing C-repeat units in a single recombinant construct. Here we show that the J14i variants chosen for inclusion in SV1 are the most common variants in a dataset of 176 unique M-proteins. Murine antibodies raised against SV1 were shown to bind to each of the J14i variants present in SV1, as well as variants not present in the vaccine. Antibodies raised to the individual J14i variants were also shown to bind to multiple but different combinations of J14i variants, supporting the underlying rationale for the design of SV1. A Lewis Rat Model of valvulitis was then used to assess the capacity of SV1 to induce deleterious immune response associated with rheumatic heart disease. In this model, both SV1 and the M5 positive control protein were immunogenic. Neither of these antibodies were cross-reactive with cardiac myosin or collagen. Splenic T cells from SV1/CFA and SV1/alum immunized rats did not proliferate in response to cardiac myosin or collagen. Subsequent histological examination of heart tissue showed that 4 of 5 mice from the M5/CFA group had valvulitis and inflammatory cell infiltration into valvular tissue, whereas mice immunised with SV1/CFA, SV1/alum showed no sign of valvulitis. These results suggest that SV1 is a safe vaccine candidate that will elicit antibodies that recognise the vast majority of circulating GAS M-types. PMID:27310707

  9. Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects.

    Science.gov (United States)

    Granata, Simona; Dalla Gassa, Alessandra; Carraro, Amedeo; Brunelli, Matteo; Stallone, Giovanni; Lupo, Antonio; Zaza, Gianluigi

    2016-01-01

    Sirolimus (SRL) and everolimus (EVR) are mammalian targets of rapamycin inhibitors (mTOR-I) largely employed in renal transplantation and oncology as immunosuppressive/antiproliferative agents. SRL was the first mTOR-I produced by the bacterium Streptomyces hygroscopicus and approved for several medical purposes. EVR, derived from SRL, contains a 2-hydroxy-ethyl chain in the 40th position that makes the drug more hydrophilic than SRL and increases oral bioavailability. Their main mechanism of action is the inhibition of the mTOR complex 1 and the regulation of factors involved in a several crucial cellular functions including: protein synthesis, regulation of angiogenesis, lipid biosynthesis, mitochondrial biogenesis and function, cell cycle, and autophagy. Most of the proteins/enzymes belonging to the aforementioned biological processes are encoded by numerous and tightly regulated genes. However, at the moment, the polygenic influence on SRL/EVR cellular effects is still not completely defined, and its comprehension represents a key challenge for researchers. Therefore, to obtain a complete picture of the cellular network connected to SRL/EVR, we decided to review major evidences available in the literature regarding the genetic influence on mTOR-I biology/pharmacology and to build, for the first time, a useful and specific "SRL/EVR genes-focused pathway", possibly employable as a starting point for future in-depth research projects. PMID:27187382

  10. Refined candidate region specified by haplotype sharing for Escherichia coli F4ab/F4ac susceptibility alleles in pigs

    DEFF Research Database (Denmark)

    Jacobsen, Mette Juul; Kracht, Steffen Skaarup; Esteso, G.; Cirera Salicio, Susanna; Edfors, I.; Archibald, A.L.; Bendixen, Christian; Andersson, L.; Fredholm, Merete; Jørgensen, Claus Bøttcher

    2009-01-01

    /resistance is presently used in a selection programme by the Danish pig breeding industry. To elucidate the genetic background involved in E. coli F4ab/ac susceptibility in pigs, a detailed haplotype map of the porcine candidate region was established. This region covers approximately 3.7 Mb. The material used...... candidate region was subjected to screening for polymorphisms, mainly focusing on intronic sequences. A total of 18 genes were partially sequenced, and polymorphisms were identified in GP5, CENTB2, APOD, PCYT1A, OSTalpha, ZDHHC19, TFRC, ACK1, MUC4, MUC20, KIAA0226, LRCH3 and MUC13. Overall, 227...

  11. Determination of Enhanced Oil Recovery Candidate Fields in the Volga-Ural Oil and Gas Region Territory

    Directory of Open Access Journals (Sweden)

    Mikhail Turbakov

    2015-10-01

    Full Text Available Most of the current Russian oil production comes from mature fields. The application of enhanced oil recovery methods on oil fields increases recovery efficiency. This article presents an analysis of the increased field development efficiency methods of the Volga-Ural oil and gas region, which allows the full and efficient development of last-stage fields with unconventional reserves and production stabilization. The selection of the optimum method for a given field is a complex procedure consisting of many stages, from collecting data about the field, through more advanced data interpretation, to working out a detailed proposal for the most efficient extraction method. In this article the instantaneous and average annual growth above wells average was taken as a performance criterion for enhanced oil recovery methods. Based on the performed analysis, it follows that candidate wells for enhanced oil recovery method use must meet the I group parameters (high values of the remaining recoverable reserves and improved reservoir properties, low water cut, obtained oil rate increase. In order to assess the possible increase in production rate after enhanced oil recovery methods hydrodynamic modeling of radial drilling, acid treatment and water-alternated-gas injection for two oil fields of the Volga-Ural oil and gas region were performed.

  12. Exclusion of linkage between hypokalemic periodic paralysis and a candidate region in 1q31-32 suggests genetic heterogeneity

    Energy Technology Data Exchange (ETDEWEB)

    Sillen, A.; Wadelius, C.; Gustabson, K.H. [University Hospital, Uppsala (Sweden)] [and others

    1994-09-01

    Familial hypokalemic periodic paralysis (HOKPP) is an autosomal dominant disease with attacks of paralysis of varying severity. The attacks occur at intervals of days to years in otherwise healthy people combined with hypokalemia during attacks. The paralysis attacks are precipitated by a number of different factors, like carbohydrate-rich meals, cold, exercise and mental stress. Recently linkage for HOKPP was shown for chromosome 1q31-32 and the disease was mapped between D1S413 and D1S249. The gene for the calcium channel alfa1-subunit (CACNL 1A3) maps to this interval and in two families no recombination was found between a polymorphism in the CACNL 1A3 gene and the disease. This gene is therefore considered to be a candidate for HOKPP. The analysis of a large Danish family excludes linkage to this region and to the CACNL 1A3 gene. In each direction from D1S413, 18.8 cM could be excluded and for D1S249, 14.9 cM. The present study clearly excludes the possibility that the gene causing HOKPP in a large Danish family is located in the region 1q31-32. This result shows that HOKPP is a heterogenous disease, with only one mapped gene so far.

  13. Investigation of candidate regions influencing litter size in Danish Landrace sows

    DEFF Research Database (Denmark)

    Bjerre, Ditte; Mark, Thomas; Sørensen, P.;

    2010-01-01

    SD of 3.5 piglets. The objective of this study was to investigate differences in identity by state relationships and allele effects associated with litter size across 17 selected microsatellite marker positions on chromosomes 11, 13, and 15. For this purpose, 357 Danish Landrace sows with high and...... low EBV for litter size were genotyped. An assignment test showed that 91 and 90% of the sows could be assigned correctly to the group of sows representing high and low EBV, respectively, based on genotype information. Allele effects were estimated separately for each marker by using deregressed EBV...

  14. CADM1 is a strong neuroblastoma candidate gene that maps within a 3.72 Mb critical region of loss on 11q23

    Directory of Open Access Journals (Sweden)

    Eggert Angelika

    2008-06-01

    Full Text Available Abstract Background Recurrent loss of part of the long arm of chromosome 11 is a well established hallmark of a subtype of aggressive neuroblastomas. Despite intensive mapping efforts to localize the culprit 11q tumour suppressor gene, this search has been unsuccessful thus far as no sufficiently small critical region could be delineated for selection of candidate genes. Methods To refine the critical region of 11q loss, the chromosome 11 status of 100 primary neuroblastoma tumours and 29 cell lines was analyzed using a BAC array containing a chromosome 11 tiling path. For the genes mapping within our refined region of loss, meta-analysis on published neuroblastoma mRNA gene expression datasets was performed for candidate gene selection. The DNA methylation status of the resulting candidate gene was determined using re-expression experiments by treatment of neuroblastoma cells with the demethylating agent 5-aza-2'-deoxycytidine and bisulphite sequencing. Results Two small critical regions of loss within 11q23 at chromosomal band 11q23.1-q23.2 (1.79 Mb and 11q23.2-q23.3 (3.72 Mb were identified. In a first step towards further selection of candidate neuroblastoma tumour suppressor genes, we performed a meta-analysis on published expression profiles of 692 neuroblastoma tumours. Integration of the resulting candidate gene list with expression data of neuroblastoma progenitor cells pinpointed CADM1 as a compelling candidate gene. Meta-analysis indicated that CADM1 expression has prognostic significance and differential expression for the gene was noted in unfavourable neuroblastoma versus normal neuroblasts. Methylation analysis provided no evidence for a two-hit mechanism in 11q deleted cell lines. Conclusion Our study puts CADM1 forward as a strong candidate neuroblastoma suppressor gene. Further functional studies are warranted to elucidate the role of CADM1 in neuroblastoma development and to investigate the possibility of CADM1

  15. CADM1 is a strong neuroblastoma candidate gene that maps within a 3.72 Mb critical region of loss on 11q23

    Science.gov (United States)

    Michels, Evi; Hoebeeck, Jasmien; De Preter, Katleen; Schramm, Alexander; Brichard, Bénédicte; De Paepe, Anne; Eggert, Angelika; Laureys, Geneviève; Vandesompele, Jo; Speleman, Frank

    2008-01-01

    Background Recurrent loss of part of the long arm of chromosome 11 is a well established hallmark of a subtype of aggressive neuroblastomas. Despite intensive mapping efforts to localize the culprit 11q tumour suppressor gene, this search has been unsuccessful thus far as no sufficiently small critical region could be delineated for selection of candidate genes. Methods To refine the critical region of 11q loss, the chromosome 11 status of 100 primary neuroblastoma tumours and 29 cell lines was analyzed using a BAC array containing a chromosome 11 tiling path. For the genes mapping within our refined region of loss, meta-analysis on published neuroblastoma mRNA gene expression datasets was performed for candidate gene selection. The DNA methylation status of the resulting candidate gene was determined using re-expression experiments by treatment of neuroblastoma cells with the demethylating agent 5-aza-2'-deoxycytidine and bisulphite sequencing. Results Two small critical regions of loss within 11q23 at chromosomal band 11q23.1-q23.2 (1.79 Mb) and 11q23.2-q23.3 (3.72 Mb) were identified. In a first step towards further selection of candidate neuroblastoma tumour suppressor genes, we performed a meta-analysis on published expression profiles of 692 neuroblastoma tumours. Integration of the resulting candidate gene list with expression data of neuroblastoma progenitor cells pinpointed CADM1 as a compelling candidate gene. Meta-analysis indicated that CADM1 expression has prognostic significance and differential expression for the gene was noted in unfavourable neuroblastoma versus normal neuroblasts. Methylation analysis provided no evidence for a two-hit mechanism in 11q deleted cell lines. Conclusion Our study puts CADM1 forward as a strong candidate neuroblastoma suppressor gene. Further functional studies are warranted to elucidate the role of CADM1 in neuroblastoma development and to investigate the possibility of CADM1 haploinsufficiency in neuroblastoma. PMID

  16. CADM1 is a strong neuroblastoma candidate gene that maps within a 3.72 Mb critical region of loss on 11q23

    International Nuclear Information System (INIS)

    Recurrent loss of part of the long arm of chromosome 11 is a well established hallmark of a subtype of aggressive neuroblastomas. Despite intensive mapping efforts to localize the culprit 11q tumour suppressor gene, this search has been unsuccessful thus far as no sufficiently small critical region could be delineated for selection of candidate genes. To refine the critical region of 11q loss, the chromosome 11 status of 100 primary neuroblastoma tumours and 29 cell lines was analyzed using a BAC array containing a chromosome 11 tiling path. For the genes mapping within our refined region of loss, meta-analysis on published neuroblastoma mRNA gene expression datasets was performed for candidate gene selection. The DNA methylation status of the resulting candidate gene was determined using re-expression experiments by treatment of neuroblastoma cells with the demethylating agent 5-aza-2'-deoxycytidine and bisulphite sequencing. Two small critical regions of loss within 11q23 at chromosomal band 11q23.1-q23.2 (1.79 Mb) and 11q23.2-q23.3 (3.72 Mb) were identified. In a first step towards further selection of candidate neuroblastoma tumour suppressor genes, we performed a meta-analysis on published expression profiles of 692 neuroblastoma tumours. Integration of the resulting candidate gene list with expression data of neuroblastoma progenitor cells pinpointed CADM1 as a compelling candidate gene. Meta-analysis indicated that CADM1 expression has prognostic significance and differential expression for the gene was noted in unfavourable neuroblastoma versus normal neuroblasts. Methylation analysis provided no evidence for a two-hit mechanism in 11q deleted cell lines. Our study puts CADM1 forward as a strong candidate neuroblastoma suppressor gene. Further functional studies are warranted to elucidate the role of CADM1 in neuroblastoma development and to investigate the possibility of CADM1 haploinsufficiency in neuroblastoma

  17. Influence of aerosol on regional precipitation in North China

    Institute of Scientific and Technical Information of China (English)

    DUAN Jing; MAO JieTai

    2009-01-01

    The possible anthropogenic aerosol effect on regional precipitation is analyzed based on the historical data of precipitation and visibility of North China. At first, the precipitation amounts from 1960 to 1979 are considered as natural background values in our study for relatively less intensive industrial activi-ties and light air pollution during that period of time, then the region is divided into different subregions by applying the clustering method including the significance test of station rainfall correlations to the time series of 10-day mean rainfall amounts in this period. Based on the rule that the precipitation characteristics are similar in the same clustering region, the correlation of precipitation amounts among all stations in each region is thus established. Secondly, for the period from 1990 to 2005, during which, the economy had experienced a rapid development in this region, the variations of visibility at each station are analyzed. The stations with the absolute change in visibility less than 0.1 km/a are used as the reference stations, at which it is assumed that precipitation has not been seriously influ-enced by anthropogenic aerosols. Then the rainfall amounts of reference stations are used to estimate the natural precipitation values of the other stations in each clustering region. The difference between estimated precipitation and measured precipitation amount is thought to result from changes in an-thropogenic aerosols. These changes in precipitation amounts caused by anthropogenic aerosols at each station are calculated using the 10-day mean rainfall values from 1990 to 2005. The analysis re-suits obtained with this method are remarkable if it passes the significance test, and therefore, the suppression of regional precipitation over the region by anthropogenic aerosol is proved. It is found that this effect is most remarkable in summer. The influence of anthropogenic aerosols on convective precipitation possibly plays an important

  18. Craniosynostosis suggestive of Saethre-Chotzen syndrome: Clinical description of a large kindred and exclusion of candidate regions on 7p

    Energy Technology Data Exchange (ETDEWEB)

    von Gernet, S.; Muehlbauer, W.; Fairley, J. [Staedtisches Krankenhaus Bogenhausen, Muenchen (Germany)] [and others

    1996-05-03

    We describe the clinical manifestations of an autosomal dominant form of craniosynostosis in a large family with eight affected relatives. Unilateral or bilateral coronal synostosis, low frontal hair line, strabismus, ptosis, and partial cutaneous syndactyly of fingers and toes are findings suggestive of the diagnosis of Saethre-Chotzen syndrome. The disease locus was excluded from the two adjacent Saethre-Chotzen candidate regions on 7p by linkage analysis with markers D7S664 and D7S507. This indicates heterogeneity of Saethre-Chotzen syndrome with a locus outside the candidate regions on 7p. 30 refs., 6 figs., 2 tabs.

  19. Conserved regions ofPlasmodium vivax potential vaccine candidate antigens in Sri Lanka:Consciousin silico analysis of prospective conformational epitope regions

    Institute of Scientific and Technical Information of China (English)

    Shanika Amarasinghe; Hashendra Kathriarachchi; Preethi Udagama

    2014-01-01

    Objective:To do mapping and modeling of conformationalB cell epitope regions of highly conserved and protective regions of three merozoitecandidate vaccine proteins ofPlasmodium vivax(P. vivax) ,ie. merozoite purface protein-1(PvMSP-1), apical membrane antigen -1 domainⅡ(PvAMA1-DⅡ) and regionⅡ of theDuffy binding protein(PvDBPⅡ), and to analyze the immunogenic properties of these predicted epitopes.Methods:3-D structures of amino acid haplotypes fromSriLanka(available inGeneBank) ofPvMSP-119(n=27),PvAMA1-DⅡ(n=21) andPvDBPⅡ(n=33) were modeled.SEPPA, selected as the best online server was used for conformational epitope predictions, while prediction and modeling of protein structure and properties related to immunogenicity was carried out withGeno3D server,SCRATCHProtein Server,NetSurfPServer and standalonesoftware,Genious5.4.4.Results:SEPPA revealed that regions of predicted conformational epitopes formed4 clusters inPvMSP-I19, and3 clusters each inPvAMA1-DⅡ andPvDBPⅡ, all of which displayed a high degree of hydrophilicity, contained solvent exposed residues, displayed high probability of antigenicity and showed positive antigenic propensity values, that indicated high degree of immunogenicity.Conclusions:Findings of this study revealed and confirmed that different parts of the sequences of each of the conserved regions of the three selected potential vaccine candidate antigens ofP. vivax are important with regard to conformational epitope prediction that warrants further laboratory experimental investigations in in vivo animal models.

  20. A profile of UK unemployment: regional versus demographic influences.

    Science.gov (United States)

    Brown, S; Sessions, J G

    1997-06-01

    "This paper profiles the incidence of unemployment in the [United Kingdom] over the period 1985-91 using data derived from the British Social Attitudes Survey. The approach of the paper is to quantify the differential probabilities of unemployment faced by particular groups within the population, focusing in particular on the relative effects of demographic and regional influences. Our results indicate that, even after controlling for a plethora of demographic characteristics, regional disparities in unemployment risk are prevalent, with individuals in Northern Ireland, Wales, the North and West Midlands of England facing a higher chance of unemployment ceteris paribus." (EXCERPT) PMID:12293417

  1. Influence of growing and exploatation of bovins on regional agroecosystems

    OpenAIRE

    Cornel Podar; Ioan Oroian; Friss Zsuzsa; Bianca Damian; I. Macarie; Daniela Ţerbea; Pop, Ioan A

    2011-01-01

    Scientists all over the are concerned regarding the influence of growing ruminants on regional agro-ecosystems due to green house gases resulted (CO 2, CH4, N2O5). Cattle have contributed to environmental pollution in old industrial farming systems, when the cattle number in Romania, reached 8 million, manure evacuation was not solved and manure was accumulating around the farm polluting the soil, water and air. Low density of ruminants existing in the agricultural sector of the country is no...

  2. CADM1 is a strong neuroblastoma candidate gene that maps within a 3.72 Mb critical region of loss on 11q23

    OpenAIRE

    Eggert Angelika; De Paepe Anne; Brichard Bénédicte; Schramm Alexander; De Preter Katleen; Hoebeeck Jasmien; Michels Evi; Laureys Geneviève; Vandesompele Jo; Speleman Frank

    2008-01-01

    Abstract Background Recurrent loss of part of the long arm of chromosome 11 is a well established hallmark of a subtype of aggressive neuroblastomas. Despite intensive mapping efforts to localize the culprit 11q tumour suppressor gene, this search has been unsuccessful thus far as no sufficiently small critical region could be delineated for selection of candidate genes. Methods To refine the critical region of 11q loss, the chromosome 11 status of 100 primary neuroblastoma tumours and 29 cel...

  3. Permissible Variation in the 3′ Non-Coding Region of the Haemagglutinin Genome Segment of the H5N1 Candidate Influenza Vaccine Cirus NIBRG-14

    OpenAIRE

    Rachel E. Johnson; Hamill, Michelle; Harvey, Ruth; Nicolson, Carolyn; Robertson, James S.; Engelhardt, Othmar G.

    2012-01-01

    The candidate H5N1 vaccine virus NIBRG-14 was created in response to a call from the World Health Organisation in 2004 to prepare candidate vaccine viruses (CVVs) to combat the threat of an H5N1 pandemic. NIBRG-14 was created by reverse genetics and is composed of the neuraminidase (NA) and modified haemagglutinin (HA) genes from A/Vietnam/1194/2004 and the internal genes of PR8, a high growing laboratory adapted influenza A(H1N1) strain. Due to time constraints, the non-coding regions (NCRs)...

  4. The Influence of Soil Characteristics in Low Flows Regionalization

    Directory of Open Access Journals (Sweden)

    Paolo Vezza

    2009-01-01

    Full Text Available Problem statement: For the purpose of low flows regionalization, relevant issue for water resources management like environmental flows requirements definition, this study focused on the controls on the seasonal and spatial variability of q95 (i.e., the specific discharge that was exceeded on 95% of all the time with particular reference to the role of soil characteristics, that, like soil infiltration rate, aquifers recharge, evapotranspiration and topography, usually play a relevant role in low flows seasonality and occurrence within a river. Approach: Piemonte and Valle d'Aosta Regions (North-Western Italy were the investigated study area (30,027 km2 where 41 catchments were analyzed with the aim of robust regression models enabling the transfer of hydrological information from gauged to un-gauged sites. Results: The regionalization method consisted of multiple regression models between low flows and catchment characteristics. Twenty-five catchment descriptors were used, checking their relative influence with the multi-regressive procedure and a special attention was devoted to the selection of significant soil characteristics in the regionalization process. Seasonality indices were used to classify catchments into two sub-regions and separate multiple regressions was performed by checking the prediction performance with cross-validation. Also a global regression was fitted out but it yielded a lower performance. In the study domain land use, topography and Thornthwaite moisture index demonstrated to be the most significant variables in order to represent relationships between catchment soil characteristics and low flows regime. Conclusion/Recommendations: Results obtained in this study were comparable with other regionalization studies carried out in Austria and Switzerland. The interpretation of the identified regression models provided, at local scale, new tools for water management and environmental flows requirements and, from a wider

  5. Influence of emissions on regional atmospheric mercury concentrations

    Directory of Open Access Journals (Sweden)

    Bieser J.

    2013-04-01

    Full Text Available Mercury is a global pollutant that is rapidly transported in the atmosphere. Unlike the majority of air pollutants the background concentrations of mercury play a major role for the atmospheric concentrations on a hemispheric scale. In this study the influence of regional anthropogenic emissions in comparison to the global emissions on mercury concentrations over Europe are investigated. For this purpose an advanced threedimensional model system is used that consists of three components. The emission model SMOKE-EU, the meteorological model COSMO-CLM, and the chemistry transport model (CTM CMAQ. A variety of sensitivity runs is performed in order to determine the influence of different driving factors (i.e. boundary conditions, anthropogenic and natural emissions, emission factors, meteorological fields on the atmoshperic concentrations of different mercury species. This study is part of the European FP7 project GMOS (Global Mercury Observation System. The aim is to identify the most important drivers for atmospheric mercury in order to optimize future regional modelling studies in the course of the GMOS project. Moreover, the model results are used to determine areas of interest for air-plane based in-situ measurements which are also part of GMOS.

  6. Evaluating Observation Influence on Regional Water Budgets in Reanalyses

    Science.gov (United States)

    Bosilovich, Michael G.; Chern, Jiun-Dar; Mocko, David; Robertson, Franklin R.; daSilva, Arlindo M.

    2014-01-01

    The assimilation of observations in reanalyses incurs the potential for the physical terms of budgets to be balanced by a term relating the fit of the observations relative to a forecast first guess analysis. This may indicate a limitation in the physical processes of the background model, or perhaps inconsistencies in the observing system and its assimilation. In the MERRA reanalysis, an area of long term moisture flux divergence over land has been identified over the Central United States. Here, we evaluate the water vapor budget in this region, taking advantage of two unique features of the MERRA diagnostic output; 1) a closed water budget that includes the analysis increment and 2) a gridded diagnostic output data set of the assimilated observations and their innovations (e.g. forecast departures). In the Central United States, an anomaly occurs where the analysis adds water to the region, while precipitation decreases and moisture flux divergence increases. This is related more to a change in the observing system than to a deficiency in the model physical processes. MERRAs Gridded Innovations and Observations (GIO) data narrow the observations that influence this feature to the ATOVS and Aqua satellites during the 06Z and 18Z analysis cycles. Observing system experiments further narrow the instruments that affect the anomalous feature to AMSUA (mainly window channels) and AIRS. This effort also shows the complexities of the observing system, and the reactions of the regional water budgets in reanalyses to the assimilated observations.

  7. Influence of Subtropical Region Strawberry Cultivars on Jelly Characteristics.

    Science.gov (United States)

    Curi, Paula Nogueira; de Sousa Tavares, Bruna; de Almeida, Aline Botelho; Pio, Rafael; Peche, Pedro Maranha; de Souza, Vanessa Rios

    2016-06-01

    At the end of the production period of strawberries grown in subtropical regions, postharvest durability is severely diminished due to rising temperatures which compromises the commercialization of fresh fruit. An ideal option would be to process strawberries in the form of preserves, jams, and jellies. Along this line it becomes extremely important to conduct a survey of which cultivars grown in subtropical regions are more suitable for processing in the form of jelly, as well as to understand what the consumer profile is for this product. The objective of this study was to evaluate the influence of different strawberry cultivars grown in subtropical regions of Brazil (Camarosa, Festival, San Andreas, Oso Grande, Camino Real, and Albion) on the physicochemical characteristics, rheological properties and sensory acceptance of the resulting jelly in order to identify cultivars with the greatest potential for industrial use. The strawberry cultivars presented different physicochemical characteristics which resulted in jellies with different physicochemical and rheological characteristics. In this study, however, we verified that all cultivars have potential to be processed in the form of jelly due to good acceptance of all formulations prepared. In general consumers prefer a lighter-colored strawberry jelly, with a less intense red color, more acidic, and less consistent/firm. PMID:27115540

  8. Influence of the Laurentian Great Lakes on Regional Climate

    Science.gov (United States)

    Notaro, M.; Holman, K.; Zarrin, A.; Fluck, E.; Vavrus, S. J.; Bennington, V.

    2012-12-01

    The influence of the Laurentian Great Lakes on climate is assessed by comparing two decade-long simulations, with the lakes either included or excluded, using the Abdus Salam International Centre for Theoretical Physics Regional Climate Model Version 4. The Great Lakes dampen the variability in near-surface air temperature across the surrounding region, while reducing the amplitude of the diurnal cycle and annual cycle of air temperature. The impacts of the Great Lakes on the regional surface energy budget include an increase (decrease) in turbulent fluxes during the cold (warm) season and an increase in surface downward shortwave radiation flux during summer due to diminished atmospheric moisture and convective cloud amount. Changes in the hydrologic budget due to the presence of the Great Lakes include increases in evaporation and precipitation during October-March and decreases during May-August, along with springtime reductions in snowmelt-related runoff. Circulation responses consist of a regionwide decrease in sea-level pressure in autumn-winter and an increase in summer, with enhanced ascent and descent in the two seasons, respectively. The most pronounced simulated impact of the Great Lakes on synoptic systems traversing the basin is a weakening of cold-season anticyclones.

  9. Influence of ENSO on Regional Indian Summer Monsoon Precipitation—Local Atmospheric Influences or Remote Influence from Pacific

    Directory of Open Access Journals (Sweden)

    Indrani Roy

    2016-02-01

    Full Text Available Using CMIP5 model outputs in different El Niño-Southern Oscillation (ENSO phases, this work investigates the indicator that could be used as an Index to characterise regional Indian Summer Monsoon (ISM precipitation. Dividing the Indian subcontinent into five arbitrarily chosen regions, viz. Central North East (CNE (18°N–31°N, 86°E–75°E, Hilly (H (28°N–38°N, 85°E–70°E, North West (NW (21°N–31°N, 79°E–67°E, North East (NE (21°N–31°N, 86°E–97°E and Southern India (S (18°N–7°N, 73°E–85°E, local wind field and remote influences from the tropical Pacific are considered to improve understanding of regional monsoon rainfall. Results are also compared with observations/reanalysis data to pinpoint areas of shortcomings and agreements. Model results suggest that regional wind velocity, viz. meridional wind component (V at 850 mb level (V850 and zonal component at 200 mb (U200 and 850 mb (U850 can yield better estimation of local precipitation in regions CNE, H and NW, agreeing well with earlier proposed monsoon Indices. Such observations are independent of different subcategories of ENSO phases and models show good correspondence with observations. Analyses with V at 200 mb (V200 indicate circulation of the upper branch of Hadley cells in regions CNE and S, though suggest the best agreement among models in comparison with other fields, but there are some deviations from observations, indicating a missing mechanism in the models. Using models, this study identified the best parameter in different regions that could be used for the regional monsoon Index, irrespective of various ENSO subcategories; for CNE it is the U200, for H it is U200 and U850, and for NW it is U850. The current analysis, however, fails to indicate anything clearly about the NE region. When focusing on the remote influence from the eastern Pacific region, it is found that atmospheric contribution to regional ISM precipitation fails to indicate

  10. A Candidate Single Nucleotide Polymorphism in the 3′ Untranslated Region of Stearoyl-CoA Desaturase Gene for Fatness Quality and the Gene Expression in Berkshire Pigs

    OpenAIRE

    Lim, Kyu-Sang; Kim, Jun-Mo; Lee, Eun-A; Choe, Jee-Hwan; Hong, Ki-Chang

    2015-01-01

    Fatness qualities in pigs measured by the amount of fat deposition and composition of fatty acids (FAs) in pork have considerable effect on current breeding goals. The stearoyl-CoA desaturase (SCD) gene plays a crucial role in the conversion of saturated FAs into monounsaturated FAs (MUFAs), and hence, is among the candidate genes responsible for pig fatness traits. Here, we identified a single nucleotide polymorphism (SNP, c.*2041T>C) in the 3′ untranslated region by direct sequencing focuse...

  11. Influence of growing and exploatation of bovins on regional agroecosystems

    Directory of Open Access Journals (Sweden)

    Cornel Podar

    2011-12-01

    Full Text Available Scientists all over the are concerned regarding the influence of growing ruminants on regional agro-ecosystems due to green house gases resulted (CO 2, CH4, N2O5. Cattle have contributed to environmental pollution in old industrial farming systems, when the cattle number in Romania, reached 8 million, manure evacuation was not solved and manure was accumulating around the farm polluting the soil, water and air. Low density of ruminants existing in the agricultural sector of the country is not significant in terms of pollution. Currently cattle have positive effects on the environment by the use of legumes, grasses and manure production contributing to the increase of agricultural production: crop production (sugar beet, potato and cereals, animal production (milk, meat, leather production and industrial production also (biogas, befouls, alcohol, oil production.

  12. Influence of Motivation Theory and Supplemental Workshops on First-Time Passing Rates of HBCU Teacher Candidates

    Science.gov (United States)

    Moffett, Noran L.; Frizzell, Melanie M.; Brownlee-Williams, Yolanda; Thompson, Jill M.

    2014-01-01

    The action research methodology for this study reports descriptive statistical findings from the performance of 19 Early Childhood Education African American teacher candidates matriculating through a state-approved program at an HBCU. Researcher-moderators provided a treatment plan of focused summer workshops, conceptualized based upon the…

  13. Revisiting regional flood frequency analysis in Slovakia: the region-of-influence method vs. traditional regional approaches

    Science.gov (United States)

    Gaál, Ladislav; Kohnová, Silvia; Szolgay, Ján.

    2010-05-01

    During the last 10-15 years, the Slovak hydrologists and water resources managers have been devoting considerable efforts to develop statistical tools for modelling probabilities of flood occurrence in a regional context. Initially, these models followed concepts to regional flood frequency analysis that were based on fixed regions, later the Hosking and Wallis's (HW; 1997) theory was adopted and modified. Nevertheless, it turned out to be that delineating homogeneous regions using these approaches is not a straightforward task, mostly due to the complex orography of the country. In this poster we aim at revisiting flood frequency analyses so far accomplished for Slovakia by adopting one of the pooling approaches, i.e. the region-of-influence (ROI) approach (Burn, 1990). In the ROI approach, unique pooling groups of similar sites are defined for each site under study. The similarity of sites is defined through Euclidean distance in the space of site attributes that had also proved applicability in former cluster analyses: catchment area, afforested area, hydrogeological catchment index and the mean annual precipitation. The homogeneity of the proposed pooling groups is evaluated by the built-in homogeneity test by Lu and Stedinger (1992). Two alternatives of the ROI approach are examined: in the first one the target size of the pooling groups is adjusted to the target return period T of the estimated flood quantiles, while in the other one, the target size is fixed, regardless of the target T. The statistical models of the ROI approach are inter-compared by the conventional regionalization approach based on the HW methodology where the parameters of flood frequency distributions were derived by means of L-moment statistics and a regional formula for the estimation of the index flood was derived by multiple regression methods using physiographic and climatic catchment characteristics. The inter-comparison of different frequency models is evaluated by means of the

  14. Physical mapping of the holoprosencephaly critical region in 21q22.3, exclusion of SIM2 as a candidate gene for holoprosencephaly, and mapping of SIM2 to a region of chromosome 21 important for Down syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Muenke, M.; Bone, L.J.; Mitchell, H.F. [Children`s Hospital of Philadelphia, PA (United States)] [and others

    1995-11-01

    We set out to define the holoprosencephaly (HPE) critical region on chromosome 21 and also to determine whether there were human homologues of the Drosophila single-minded (sim) gene that might be involved in HPE. Analysis of somatic cell hybrid clones that contained rearranged chromosomes 21 from HPE patients defined the HPE minimal critical region in 21q22.3 as D21S113 to qter. We used established somatic cell hybrid mapping panels to map SIM2 to chromosome 21 within subbands q22.2-q22.3. Analysis of the HPE patient-derived somatic cell hybrids showed that SIM2 is not deleted in two of three patients and thus is not a likely candidate for HPE1, the HPE gene on chromosome 21. However, SIM2 does map within the Down syndrome critical region and thus is a candidate gene that might contribute to the Down syndrome phenotype. 31 refs., 2 figs., 1 tab.

  15. Physical Mapping of the Holoprosencephaly Critical Region in 21q22.3, Exclusion of SIM2 as a Candidate Gene for Holoprosencephaly, and Mapping of SIM2 to a Region of Chromosome 21 Important for Down Syndrome

    Science.gov (United States)

    Muenke, Maximilian; Bone, Linda J.; Mitchell, Heather F.; Hart, Iris; Walton, Katy; Hall-Johnson, Karen; Ippel, Elly F.; Dietz-Band, Jeanne; Kvaløy, Kirsti; Fan, Chen-Ming; Tessier-Lavigne, Marc; Patterson, David

    1995-01-01

    We set out to define the holoprosencephaly (HPE) critical region on chromosome 21 and also to determine whether there were human homologues of the Drosophila single-minded (sim) gene that might be involved in HPE. Analysis of somatic cell hybrid clones that contained rearranged chromosomes 21 from HPE patients defined the HPE minimal critical region in 21q22.3 as D21S113 to qter. We used established somatic cell hybrid mapping panels to map SIM2 to chromosome 21 within subbands q22.2-q22.3. Analysis of the HPE patient–derived somatic cell hybrids showed that SIM2 is not deleted in two of three patients and thus is not a likely candidate for HPE1, the HPE gene on chromosome 21. However, SIM2 does map within the Down syndrome critical region and thus is a candidate gene that might contribute to the Down syndrome phenotype. ImagesFigure 1 PMID:7485157

  16. Analysis of t(9;17)(q33.2;q25.3) chromosomal breakpoint regions and genetic association reveals novel candidate genes for bipolar disorder

    DEFF Research Database (Denmark)

    Rajkumar, A.P.; Christensen, Jane H.; Mattheisen, Manuel;

    2015-01-01

    OBJECTIVES: Breakpoints of chromosomal abnormalities facilitate identification of novel candidate genes for psychiatric disorders. Genome-wide significant evidence supports the linkage between chromosome 17q25.3 and bipolar disorder (BD). Co-segregation of translocation t(9;17)(q33.2;q25.3) with...... psychiatric disorders has been reported. We aimed to narrow down these chromosomal breakpoint regions and to investigate the associations between single nucleotide polymorphisms within these regions and BD as well as schizophrenia (SZ) in large genome-wide association study samples. METHODS: We cross......-linked Danish psychiatric and cytogenetic case registers to identify an individual with both t(9;17)(q33.2;q25.3) and BD. Fluorescent in situ hybridization was employed to map the chromosomal breakpoint regions of this proband. We accessed the Psychiatric Genomics Consortium BD (n = 16,731) and SZ (n = 21...

  17. Evaluation of novel Streptococcus pyogenes vaccine candidates incorporating multiple conserved sequences from the C-repeat region of the M-protein.

    Science.gov (United States)

    Bauer, Michelle J; Georgousakis, Melina M; Vu, Therese; Henningham, Anna; Hofmann, Andreas; Rettel, Mandy; Hafner, Louise M; Sriprakash, Kadaba S; McMillan, David J

    2012-03-01

    A major challenge for Streptococcus pyogenes vaccine development is the identification of epitopes that confer protection from infection by multiple S. pyogenes M-types. Here we have identified and characterised the distribution of common variant sequences from individual repeat units of the C-repeat region (CRR) of M-proteins representing 77 different M-types. Three polyvalent fusion vaccine candidates (SV1, SV2 and SV3) incorporating the most common variants were subsequently expressed and purified, and demonstrated to be alpha-helical by Circular Dichroism (CD), a secondary conformational characteristic of the CRR in the M-protein. Antibodies raised against each of these constructs recognise M-proteins that vary in their CRR, and bind to the surface of multiple S. pyogenes isolates. Antibodies raised against SV1, containing five variant sequences, also kill heterologous S. pyogenes isolates in in vitro bactericidal assays. Further structural characterisation of this construct demonstrated the conformation of SV1 was stable at different pHs, and thermal unfolding of SV1 is a reversible process. Our findings demonstrate that linkage of multiple variant sequences into a single recombinant construct overcomes the need to embed the variant sequences in foreign helix promoting flanking sequences for conformational stability, and demonstrates the viability of the polyvalent candidates as global S. pyogenes vaccine candidates. PMID:22265945

  18. The role of banks in influencing regional flow of funds

    OpenAIRE

    Katherine A. Samolyk

    1989-01-01

    A presentation of a theoretical model of regional banking using plausible information asymmetries to explain how local bank capital may affect the funding of regional investments, concluding that regional banking conditions can affect the efficiency of investment and the level of future aggregate output.

  19. Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies

    Directory of Open Access Journals (Sweden)

    Gonzalez-Neira Anna

    2007-08-01

    Full Text Available Abstract Background The recent development of new high-throughput technologies for SNP genotyping has opened the possibility of taking a genome-wide linkage approach to the search for new candidate genes involved in heredity diseases. The two major breast cancer susceptibility genes BRCA1 and BRCA2 are involved in 30% of hereditary breast cancer cases, but the discovery of additional breast cancer predisposition genes for the non-BRCA1/2 breast cancer families has so far been unsuccessful. Results In order to evaluate the power improvement provided by using SNP markers in a real situation, we have performed a whole genome screen of 19 non-BRCA1/2 breast cancer families using 4720 genomewide SNPs with Illumina technology (Illumina's Linkage III Panel, with an average distance of 615 Kb/SNP. We identified six regions on chromosomes 2, 3, 4, 7, 11 and 14 as candidates to contain genes involved in breast cancer susceptibility, and additional fine mapping genotyping using microsatellite markers around linkage peaks confirmed five of them, excluding the region on chromosome 3. These results were consistent in analyses that excluded SNPs in high linkage disequilibrium. The results were compared with those obtained previously using a 10 cM microsatellite scan (STR-GWS and we found lower or not significant linkage signals with STR-GWS data compared to SNP data in all cases. Conclusion Our results show the power increase that SNPs can supply in linkage studies.

  20. Exclusion of candidate genes from the chromosome 1q juvenile glaucoma region and mapping of the peripheral cannabis receptor gene (CNR2) to chromosome 1

    Energy Technology Data Exchange (ETDEWEB)

    Sunden, S.L.F.; Nichols, B.E.; Alward, W.L.M. [Univ. of Iowa, Iowa City, IA (United States)] [and others

    1994-09-01

    Juvenile onset primary open angle glaucoma has been mapped by linkage to 1q21-q31. Several candidate genes were evaluated in the same family used to identify the primary linkage. Atrionatriuretic peptide receptor A (NPR1) and laminin C1 (LAMC1) have been previously mapped to this region and could putatively play a role in the pathogenesis of glaucoma. A third gene, the peripheral cannabis receptor (CNR2) was not initially mapped in humans but was a candidate because of the relief that cannabis affords some patients with primary open angle glaucoma. Microsatellites associated with NPR1 and LAMC1 revealed multiple recombinations in affected members of this pedigree. CNR2 was shown to be on chromosome 1 by PCR amplification of a 150 bp fragment of the 3{prime} untranslated region in monochromosomal somatic cell hybrids (NIGMS panel No. 2). These primers also revealed a two allele single strand conformation polymorphism which showed multiple recombinants with juvenile onset primary open angle glaucoma in large pedigrees, segregating this disorder. The marker was then mapped to 1p34-p36 by linkage, with the most likely location between liver alkaline phosphatase (ALPL) and alpha-L-1 fucosidase (FUCA1).

  1. Localization of the candidate gene d-amino acid oxidase outside the refined 1-cM region of spinocerebellar ataxia 2

    Energy Technology Data Exchange (ETDEWEB)

    Auburger, G.; Gispert, S.; Lunkes, A. [Univ. Hospital, Duesseldorf (Germany)] [and others

    1995-10-01

    Spinocerebellar ataxia 2 (SCA2) is one form of the neurodegenerative autosomal dominant cerebellar ataxias and has been linked to chromosome 12q in 25 previously described and 13 new families from a founder collective of {ge}500 patients in Holguin, Cuba. Although SCA2 in most patients cannot be distinguished from other spinocerebellar ataxias by clinical criteria, in some patients it exhibits a particular phenotype with early neuropathy/late slow saccades and late myoclonus. Autopsy in 11 patients demonstrated olivo-ponto-cerebellar atrophy with a selective sparing of the dentate nucleus. Complete allelic association within the Holguin population was established with the microsatellite D12S105, and the candidate region was determined to be within a 6-cM region distal to the marker D12S84, contrasting previous reports by Pulst and Lopes-Cendes and according to preliminary data between D12S84 and D12S1329. 17 refs., 1 fig., 1 tab.

  2. The Candidate

    OpenAIRE

    Osborn, John C

    2013-01-01

    ABSTRACT   The Candidate is an attempt to marry elements of journalism and gaming into a format that both entertains and educates the player. The Google-AP Scholarship, a new scholarship award that is given to several journalists a year to work on projects at the threshold of technology and journalism, funded the project. The objective in this prototype version of the game is to put the player in the shoes of a congressional candidate during an off-year election, specificall...

  3. Fine Mapping of a GWAS-Derived Obesity Candidate Region on Chromosome 16p11.2

    Science.gov (United States)

    Jarick, Ivonne; Pütter, Carolin; Göbel, Maria; Horn, Lucie; Struve, Christoph; Haas, Katharina; Knoll, Nadja; Grallert, Harald; Illig, Thomas; Reinehr, Thomas; Wang, Hai-Jun; Hebebrand, Johannes; Hinney, Anke

    2015-01-01

    Introduction Large-scale genome-wide association studies (GWASs) have identified 97 chromosomal loci associated with increased body mass index in population-based studies on adults. One of these SNPs, rs7359397, tags a large region (approx. 1MB) with high linkage disequilibrium (r²>0.7), which comprises five genes (SH2B1, APOBR, sulfotransferases: SULT1A1 and SULT1A2, TUFM). We had previously described a rare mutation in SH2B1 solely identified in extremely obese individuals but not in lean controls. Methods The coding regions of the genes APOBR, SULT1A1, SULT1A2, and TUFM were screened for mutations (dHPLC, SSCP, Sanger re-sequencing) in 95 extremely obese children and adolescents. Detected non-synonymous variants were genotyped (TaqMan SNP Genotyping, MALDI TOF, PCR-RFLP) in independent large study groups (up to 3,210 extremely obese/overweight cases, 485 lean controls and 615 obesity trios). In silico tools were used for the prediction of potential functional effects of detected variants. Results Except for TUFM we detected non-synonymous variants in all screened genes. Two polymorphisms rs180743 (APOBR p.Pro428Ala) and rs3833080 (APOBR p.Gly369_Asp370del9) showed nominal association to (extreme) obesity (uncorrected p = 0.003 and p = 0.002, respectively). In silico analyses predicted a functional implication for rs180743 (APOBR p.Pro428Ala). Both APOBR variants are located in the repetitive region with unknown function. Conclusion Variants in APOBR contributed as strongly as variants in SH2B1 to the association with extreme obesity in the chromosomal region chr16p11.2. In silico analyses implied no functional effect of several of the detected variants. Further in vitro or in vivo analyses on the functional implications of the obesity associated variants are warranted. PMID:25955518

  4. Regional profiles of the candidate tau PET ligand 18F-AV-1451 recapitulate key features of Braak histopathological stages.

    Science.gov (United States)

    Schwarz, Adam J; Yu, Peng; Miller, Bradley B; Shcherbinin, Sergey; Dickson, James; Navitsky, Michael; Joshi, Abhinay D; Devous, Michael D; Mintun, Mark S

    2016-05-01

    SEE THAL AND VANDENBERGHE DOI101093/BRAIN/AWW057 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Post-mortem Braak staging of neurofibrillary tau tangle topographical distribution is one of the core neuropathological criteria for the diagnosis of Alzheimer's disease. The recent development of positron emission tomography tracers targeting neurofibrillary tangles has enabled the distribution of tau pathology to be imaged in living subjects. Methods for extraction of classic Braak staging from in vivo imaging of neurofibrillary tau tangles have not yet been explored. Standardized uptake value ratio images were calculated from 80-100 minute (18)F-AV-1451 (also known as T807) positron emission tomography scans obtained from n = 14 young reference subjects (age 21-39 years, Mini-Mental State Examination 29-30) and n = 173 older test subjects (age 50-95 years) comprising amyloid negative cognitively normal (n = 42), clinically-diagnosed mild cognitive impairment (amyloid positive, n = 47, and amyloid negative, n = 40) and Alzheimer's disease (amyloid positive, n = 28, and amyloid negative, n = 16). We defined seven regions of interest in anterior temporal lobe and occipital lobe sections corresponding closely to those used as decision points in Braak staging. An algorithm based on the Braak histological staging procedure was applied to estimate Braak stages directly from the region of interest profiles in each subject. Quantitative region-based analysis of (18)F-AV-1451 images yielded region of interest and voxel level profiles that mirrored key features of neuropathological tau progression including profiles consistent with Braak stages 0 through VI. A simple set of decision rules enabled plausible Braak stages corresponding to stereotypical progression patterns to be objectively estimated in 149 (86%) of test subjects. An additional 12 (7%) subjects presented with predefined variant profiles (relative sparing of the hippocampus and/or occipital lobe). The estimated Braak

  5. Using Single-nucleotide Polymorphisms and Genetic Mapping to find Candidate Genes that Influence Varroa-Specific Hygiene

    Science.gov (United States)

    Varroa-sensitive hygienic (VSH) behavior is one of two behaviors identified that are most important for controlling the growth of Varroa mite populations in bee hives. A study was conducted to map quantitative trait loci (QTL) that influence VSH so that resistance genes could be identified. Crosses ...

  6. Permissible variation in the 3' non-coding region of the haemagglutinin genome segment of the H5N1 candidate influenza vaccine virus NIBRG-14 [corrected].

    Science.gov (United States)

    Johnson, Rachel E; Hamill, Michelle; Harvey, Ruth; Nicolson, Carolyn; Robertson, James S; Engelhardt, Othmar G

    2012-01-01

    The candidate H5N1 vaccine virus NIBRG-14 was created in response to a call from the World Health Organisation in 2004 to prepare candidate vaccine viruses (CVVs) to combat the threat of an H5N1 pandemic. NIBRG-14 was created by reverse genetics and is composed of the neuraminidase (NA) and modified haemagglutinin (HA) genes from A/Vietnam/1194/2004 and the internal genes of PR8, a high growing laboratory adapted influenza A(H1N1) strain. Due to time constraints, the non-coding regions (NCRs) of A/Vietnam/1194/2004 HA were not determined prior to creating NIBRG-14. Consequently, the sequence of the primers used to clone the modified A/Vietnam/1194/2004 HA was based upon previous experience of cloning H5N1 viruses. We report here that the HA 3' NCR sequence of NIBRG-14 is different to that of the parental wild type virus A/Vietnam/1194/2004; however this does not appear to impact on its growth or antigen yield. We introduced additional small changes into the 3'NCR of NIBRG-14; these had only minor effects on viral growth and antigen content. These findings may serve to assure the influenza vaccine community that generation of CVVs using best-guess NCR sequences, based on sequence alignments, are likely to produce robust viruses. PMID:22606247

  7. Revaluating regional influences of ICT factors in Hungary

    OpenAIRE

    Jakobi, Akos

    2005-01-01

    At the beginning of the 21st century ICT factors got growing importance in shaping regional differences in Hungary. Determining differences of ICT competitiveness became needful in analysing regional inequalities recently, however, according to some opinions there are ICT-like factors on the scene for longer time. Depending on theories and interpretations these factors are treated mainly as new although sometimes as traditional ones. In accordance with the generally accepted approaches ICT fa...

  8. DYNAMIC FACTORS INFLUENCING U.S. AND REGIONAL CATFISH DEMAND

    OpenAIRE

    Houston, Jack E.; Ermita, Isabel

    1992-01-01

    Response to changes in factors influencing consumption of catfish and competing commodities differ between national, South Atlantic, and Southwest Central markets. A modified state adjustment model for catfish, beef, chicken, and other fish explicitly included age distribution, residence, occupation, education, and race/ethnic variables associated with habit formation. Nationally, per capita expenditures on catfish respond to present and past relative prices, and catfish, chicken, and other f...

  9. Implementing regional innovation policies: doctrines and factors of influence

    OpenAIRE

    Høyer, Hans Christian

    2014-01-01

    This article examines the implementation of regional innovation policies by focusing on a selected group of bureaucrats and evaluating the characteristics of the doctrines of action they utilize when creating innovation. The data used in the article were collected through in-depth interviews conducted with 21 employees in the Trade and Industry Departments in two county administrations, the offices of Innovation Norway in two counties and the Agricultural Departments of t...

  10. Influence of microscale in snow distributed modelling in semiarid regions

    OpenAIRE

    Pimentel Leiva, Rafael

    2015-01-01

    This work focuses on the importance of the microscale snow distribution in the modelling of the snow dynamics in semiarid regions. Snow over these areas has particular features that further complicate its measuring, monitoring and modelling (e.g. several snowmelt cycles throughout the year and a very heterogeneous distribution). Most extended GIS-based calculation of snowmelt/accumulation models must deal with non-negligible scales effects below the cell size, which may result ...

  11. Local Productive Arrangements and their influences in regional economics development

    Directory of Open Access Journals (Sweden)

    Demeure Adolfo Menezes Pessoa

    2009-03-01

    Full Text Available The article possesses the mark of demonstrating the paper of the clusters in the regional economical development by the actors' cooperation in the productive chain. By this way was used a bibliographical review and descriptive-exploratory as methodology to realize this work. The article shows as it results the substation of the companies agglomerateds formation in several region, do they belongs at the same business or of the existing companies suppliers, like a alternative way to search of the competitive advantadge.  That can be deserved yet like a new economic trend in Brazil and in the other wolrd region, that do the companies adopt a different way in front of the new challenges. By the way it´s generator of a new economic geography of development, therefore to start from the moment that occurs this corporate cohesion, whose purpose is the seek of the competitive advantadge, that can be used to put down the production costs, to promote the exportation and permit the technological innovations.

  12. REGIONAL DISPARITIES – HISTORICAL CULTURAL INFLUENCES AND REGIONAL DEVELOPMENT IN ROMANIA

    OpenAIRE

    MARIA OTIL; MONICA BOLDEA

    2015-01-01

    In recent decades, the issue of regional disparities has become a highly debated topic, knowledge regarding regional disparities being a matter of political priority as their persistence hinders the appropriate integration process. On the other hand, emphasis was put on integration through the process of EU enlargement, thus highlighting other issues related to the nature and size of disparities. Regional disparities regarding development and the living standards of the population have long b...

  13. A Synthetic Virus-Like Particle Streptococcal Vaccine Candidate Using B-Cell Epitopes from the Proline-Rich Region of Pneumococcal Surface Protein A

    Directory of Open Access Journals (Sweden)

    Marco Tamborrini

    2015-10-01

    Full Text Available Alternatives to the well-established capsular polysaccharide-based vaccines against Streptococcus pneumoniae that circumvent limitations arising from limited serotype coverage and the emergence of resistance due to capsule switching (serotype replacement are being widely pursued. Much attention is now focused on the development of recombinant subunit vaccines based on highly conserved pneumococcal surface proteins and virulence factors. A further step might involve focusing the host humoral immune response onto protective protein epitopes using as immunogens structurally optimized epitope mimetics. One approach to deliver such epitope mimetics to the immune system is through the use of synthetic virus-like particles (SVLPs. SVLPs are made from synthetic coiled-coil lipopeptides that are designed to spontaneously self-assemble into 20–30 nm diameter nanoparticles in aqueous buffer. Multivalent display of epitope mimetics on the surface of SVLPs generates highly immunogenic nanoparticles that elicit strong epitope-specific humoral immune responses without the need for external adjuvants. Here, we set out to demonstrate that this approach can yield vaccine candidates able to elicit a protective immune response, using epitopes derived from the proline-rich region of pneumococcal surface protein A (PspA. These streptococcal SVLP-based vaccine candidates are shown to elicit strong humoral immune responses in mice. Following active immunization and challenge with lethal doses of streptococcus, SVLP-based immunogens are able to elicit significant protection in mice. Furthermore, a mimetic-specific monoclonal antibody is shown to mediate partial protection upon passive immunization. The results show that SVLPs combined with synthetic epitope mimetics may have potential for the development of an effective vaccine against Streptococcus pneumoniae.

  14. Processes influencing rainfall features in the Amazonian region

    Science.gov (United States)

    Gerken, T.; Chamecki, M.; Fuentes, J. D.; Katul, G. G.; Fitzjarrald, D. R.; Manzi, A. O.; Nascimento dos Santos, R. M.; von Randow, C.; Stoy, P. C.; Tota, J.; Trowbridge, A.; Schumacher, C.; Machado, L.

    2014-12-01

    The Amazon is globally unique as it experiences the deepest atmospheric convection with important teleconnections to other parts of the Earth's climate system. In the Amazon Basin a large fraction of the local evapotranspiration is recycled through the formation of deep convective precipitating storms. Deep convection occurs due to moist thermodynamic conditions associated with elevated amounts of convective available potential energy. Aerosols invigorate the formation of convective storms in the Amazon via their unique concentrations, physical size, and chemical composition to activate into cloud condensation nuclei (CCN), but important aspects of aerosol/precipitation feedbacks remain unresolved. During the wet season, low atmospheric aerosol concentrations prevail in the pristine tropical air masses. These conditions have led to the Green Ocean hypothesis, which compares the clean tropical air to maritime air-masses and emphasizes biosphere-atmosphere feedbacks, to explain the features of the convective-type rainfall events in the Amazon. Field studies have been designed to investigate these relationships and the development of mesoscale convective systems through the Green Ocean Amazon project and the GOAmazon Boundary Layer Experiment. From March to October 2014 a field experiment was conducted at the Cuieiras Biological Reserve (2°51' S, 54°58' W), 80 km north of the city of Manaus, Brazil. This investigation spans the biological, chemical, and physical conditions influencing emissions and reactions of precursors (biogenic and anthropogenic volatile organic compounds, VOCs), formation of aerosols and CCNs and transport out of the ABL, and their role in cloud formation and precipitation triggers. In this presentation we will show results on the magnitude turbulent fluxes of latent and sensible heat, CCN concentrations, and rain droplet size distribution for both the wet and dry season. Such influencing factors on precipitation, will be contrasted with the

  15. Electoral Systems and Candidate Selection

    NARCIS (Netherlands)

    Hazan, Reuven Y.; Voerman, Gerrit

    2006-01-01

    Electoral systems at the national level and candidate selection methods at the party level are connected, maybe not causally but they do influence each other. More precisely, the electoral system constrains and conditions the parties' menu of choices concerning candidate selection. Moreover, in ligh

  16. The study of mutations of low penetrates candidate genes, participating in appearance of breast cancer in patients from different regions of Belarus

    International Nuclear Information System (INIS)

    Breast cancer is the most widespread malignancy in the world. It is supposed, that all factors influencing on breast cancer onset can be divided into 4 groups: environmental factors, state of woman's health, heredity and concomitant disease. The inherited disposition towards breast cancer is complex, and many genetic variants and polymorphisms have been postulated to play a role in this condition. Despite genes with a high penetrance, known some genes with a low penetrance, such as ATM, CHEK2 and XRCC4. Ionizing radiation is for long being recognized as a potent carcinogen. The link between exposition to high doses of radiation and a subsequent development of breast cancer has been shown in numerous epidemiological studies. Because mutations in the known genes explain less than half of all multiple-case families, other genes involved in these repair pathways are now under current investigation in many different labs worldwide to define their role in breast cancer predisposition. The purpose of this paper is to study mutations of low penetrate candidate genes, participating in appearance of breast cancer in Byelorussian patients. This study is for the first time reveals the mutations of breast cancer genes in the Byelorussian population. Were used such methods as extraction of DNA, PCR, ARMAS-PCR and restriction analysis for this study. As a result of the work frequent mutations of CHEK2 and XRCC4 were found in family cases. It is shown that following methods are useful for cancer risk prediction for patients and their blood relatives. (authors)

  17. ANNUAL PARALLAX DETERMINATION TOWARD A NEW X-RAY-EMITTING CLASS 0 CANDIDATE WITH THE WATER MASER IN THE NGC 2264 STAR-FORMING REGION

    Energy Technology Data Exchange (ETDEWEB)

    Kamezaki, Tatsuya; Imura, Kenji; Omodaka, Toshihiro; Handa, Toshihiro [Department of Physics and Astronomy, Graduate School of Science and Engineering, Kagoshima University, 1-21-35 Korimoto, Kagoshima 890-0065 (Japan); Tsuboi, Yohko [Department of Physics, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo, Tokyo 112-8551 (Japan); Nagayama, Takumi; Hirota, Tomoya; Sunada, Kazuyoshi; Kobayashi, Hideyuki [Mizusawa VLBI Observatory, Mitaka Office, National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Chibueze, James O. [East Asian ALMA Regional Center, National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Kawai, Eiji [Kashima Space Technology Center, National Institute of Information and Communications Technology, 893-1 Hirai, Kashima, Ibaraki 314-8501 (Japan); Nakano, Makoto, E-mail: kamezaki@milkyway.sci.kagoshima-u.ac.jp [Faculty of Education and Welfare Science, Oita University, Oita 870-1192 (Japan)

    2014-04-01

    In our multi-epoch observation of the star-forming region NGC 2264 with the VLBI Exploration of Radio Astrometry, we detected two water maser features. We have measured the annual parallax of the maser sources for the first time in NGC 2264 and derived 1.356 ± 0.098 mas, corresponding to the distance of 738{sub −50}{sup +57} pc, which is consistent with its previously reported photometric observations. One of the maser features is located near a dust continuum core, CMM4S, positionally corresponding to the X-ray source FMS2-1269 listed in Flaccomio et al. Re-analyzing Chandra X-ray data, we found that FMS2-1269 is still surrounded by a dense envelope of a H{sub 2} column density, 5.4 × 10{sup 23} cm{sup –2}. We suggest that the maser detected near the CMM4S core is most likely associated with the X-ray-emitting Class 0 candidate FMS2-1269. The other maser feature is found to emerge from a high-velocity outflow of 150 km s{sup –1} and is associated with the 3.6 cm radio continuum source NGC 2264 VLA 3 located close to IRS1.

  18. ANNUAL PARALLAX DETERMINATION TOWARD A NEW X-RAY-EMITTING CLASS 0 CANDIDATE WITH THE WATER MASER IN THE NGC 2264 STAR-FORMING REGION

    International Nuclear Information System (INIS)

    In our multi-epoch observation of the star-forming region NGC 2264 with the VLBI Exploration of Radio Astrometry, we detected two water maser features. We have measured the annual parallax of the maser sources for the first time in NGC 2264 and derived 1.356 ± 0.098 mas, corresponding to the distance of 738−50+57 pc, which is consistent with its previously reported photometric observations. One of the maser features is located near a dust continuum core, CMM4S, positionally corresponding to the X-ray source FMS2-1269 listed in Flaccomio et al. Re-analyzing Chandra X-ray data, we found that FMS2-1269 is still surrounded by a dense envelope of a H2 column density, 5.4 × 1023 cm–2. We suggest that the maser detected near the CMM4S core is most likely associated with the X-ray-emitting Class 0 candidate FMS2-1269. The other maser feature is found to emerge from a high-velocity outflow of 150 km s–1 and is associated with the 3.6 cm radio continuum source NGC 2264 VLA 3 located close to IRS1

  19. High density genome wide genotyping-by-sequencing and association identifies common and low frequency SNPs, and novel candidate genes influencing cow milk traits

    Science.gov (United States)

    Ibeagha-Awemu, Eveline M.; Peters, Sunday O.; Akwanji, Kingsley A.; Imumorin, Ikhide G.; Zhao, Xin

    2016-01-01

    High-throughput sequencing technologies have increased the ability to detect sequence variations for complex trait improvement. A high throughput genome wide genotyping-by-sequencing (GBS) method was used to generate 515,787 single nucleotide polymorphisms (SNPs), from which 76,355 SNPs with call rates >85% and minor allele frequency ≥1.5% were used in genome wide association study (GWAS) of 44 milk traits in 1,246 Canadian Holstein cows. GWAS was accomplished with a mixed linear model procedure implementing the additive and dominant models. A strong signal within the centromeric region of bovine chromosome 14 was associated with test day fat percentage. Several SNPs were associated with eicosapentaenoic acid, docosapentaenoic acid, arachidonic acid, CLA:9c11t and gamma linolenic acid. Most of the significant SNPs for 44 traits studied are novel and located in intergenic regions or introns of genes. Novel potential candidate genes for milk traits or mammary gland functions include ERCC6, TONSL, NPAS2, ACER3, ITGB4, GGT6, ACOX3, MECR, ADAM12, ACHE, LRRC14, FUK, NPRL3, EVL, SLCO3A1, PSMA4, FTO, ADCK5, PP1R16A and TEP1. Our study further demonstrates the utility of the GBS approach for identifying population-specific SNPs for use in improvement of complex dairy traits. PMID:27506634

  20. Strong influence of regional species pools on continent-wide structuring of local communities

    DEFF Research Database (Denmark)

    Lessard, Jean-Philippe; Borregaard, Michael Krabbe; Fordyce, James A.; Rahbek, Carsten; Weiser, Michael D.; Dunn, Robert R.; Sanders, Nate

    2012-01-01

    There is a long tradition in ecology of evaluating the relative contribution of the regional species pool and local interactions on the structure of local communities. Similarly, a growing number of studies assess the phylogenetic structure of communities, relative to that in the regional species...... a continent-wide dataset of local ant communities and implement ecologically explicit source pool definitions to examine the relative importance of regional species pools and local interactions for shaping community structure. Then we assess which factors underlie systematic variation in the...... that the evolution of climatic niches influences the phylogenetic structure of regional source pools and that the influence of regional source pools on local community structure is strong....

  1. Association and haplotype analysis of candidate genes in five genomic regions linked to sow maternal infanticide in a white Duroc × Erhualian resource population

    Directory of Open Access Journals (Sweden)

    Ding Nengshui

    2011-02-01

    Full Text Available Abstract Background Maternal infanticide is an extreme and failed maternal behavior, which is defined as an active attack on piglets using the jaws, resulting in serious or fatal bite wounds. It brings big economic loss to the pig industry and severe problems to piglets' welfare. But little is known about the genetic background of this behavior. Quantitative trait loci (QTL for maternal infanticide were identified in a White Duroc × Erhualian intercross by a non-parametric linkage analysis (NPL in our previous study. In this study, associations of 194 microsatellite markers used in NPL analysis with maternal infanticide behavior were further analyzed by transmission-disequilibrium test (TDT. On this basis, seven genes (ESR2, EAAT2, BDNF, OXTR, 5-HTR2C, DRD1 and GABRA6 at five genomic regions were selected and further analyzed. Associations of single nucleotide polymorphisms (SNPs and haplotypes in each gene with maternal infanticide behavior were evaluated. Results Microsatellite markers on pig chromosome (SSC 2, 13, 15, and X displayed significance at P ESR2 SNPs had nominal evidence for association (P A at EAAT2 g. 233G > A and allele T at DRD1 g.1013C > G > T also showed evidence of overtransmission to infanticidal sows. In the overall tests of association of haplotypes, candidate genes of ESR2, EAAT2 and DRD1 achieved overall significance level (P ESR2, EAAT2 and DRD1 showed higher frequencies to infanticidal sows (P Conclusions From association tests of SNPs and haplotypes, ESR2, EAAT2 and DRD1 showed significant associations with maternal infanticide. This result supported the existence of QTL for maternal infanticide behavior on SSC1, SSC2 and SSC16.

  2. Influence of climate change on the water resources in an alpine region.

    Science.gov (United States)

    De Toffol, S; Engelhard, C; Rauch, W

    2008-01-01

    It is widely accepted that the global warming will impact on water resources. This study investigates the possible influence of climate change on the water resources in an alpine region. A description of the actual situation with emphasis on the water resources from the one side and on the water consuming factors, here called stressors, is given. The probable effects of climate change in the region and their influence on its water resources are then described. The main outcome is that in the analysed region the climate change will rather have positive influence on the water balance by inducing higher precipitations during the rivers' natural low flow period (winter). This outcome contradicts many common predictions, however, this due to the specifics induced by the alpine nature of the catchment. PMID:18776619

  3. Influence investigation of a void region on modeling light propagation in a heterogeneous medium.

    Science.gov (United States)

    Yang, Defu; Chen, Xueli; Ren, Shenghan; Qu, Xiaochao; Tian, Jie; Liang, Jimin

    2013-01-20

    A void region exists in some biological tissues, and previous studies have shown that inaccurate images would be obtained if it were not processed. A hybrid radiosity-diffusion method (HRDM) that couples the radiosity theory and the diffusion equation has been proposed to deal with the void problem and has been well demonstrated in two-dimensional and three-dimensional (3D) simple models. However, the extent of the impact of the void region on the accuracy of modeling light propagation has not been investigated. In this paper, we first implemented and verified the HRDM in 3D models, including both the regular geometries and a digital mouse model, and then investigated the influences of the void region on modeling light propagation in a heterogeneous medium. Our investigation results show that the influence of the region can be neglected when the size of the void is less than a certain range, and other cases must be taken into account. PMID:23338186

  4. Strong influence of regional species pools on continent-wide structuring of local communities

    OpenAIRE

    Lessard, Jean-Philippe; Borregaard, Michael K.; Fordyce, James A.; Rahbek, Carsten; Weiser, Michael D.; Dunn, Robert R.; Sanders, Nathan J

    2011-01-01

    There is a long tradition in ecology of evaluating the relative contribution of the regional species pool and local interactions on the structure of local communities. Similarly, a growing number of studies assess the phylogenetic structure of communities, relative to that in the regional species pool, to examine the interplay between broad-scale evolutionary and fine-scale ecological processes. Finally, a renewed interest in the influence of species source pools on communities has shown that...

  5. Region-of-influence approach to a frequency analysis of heavy precipitation in Slovakia

    Czech Academy of Sciences Publication Activity Database

    Gaál, L.; Kyselý, Jan; Szolgay, J.

    2007-01-01

    Roč. 4, č. 4 (2007), s. 2361-2401. ISSN 1812-2108 R&D Projects: GA AV ČR KJB300420601 Institutional research plan: CEZ:AV0Z30420517 Keywords : regional frequency analysis * region-of-influence approach * pooling groups * extreme precipitation events * L-moments * Slovakia Subject RIV: DG - Athmosphere Sciences, Meteorology http://www.hydrol-earth-syst-sci-discuss.net/4/2361/2007/

  6. Region-of-influence approach to a frequency analysis of heavy precipitation in Slovakia

    Czech Academy of Sciences Publication Activity Database

    Gaál, L.; Kyselý, Jan; Szolgay, J.

    2008-01-01

    Roč. 12, č. 3 (2008), s. 825-839. ISSN 1027-5606 R&D Projects: GA AV ČR KJB300420601 Institutional research plan: CEZ:AV0Z30420517 Keywords : regional frequency analysis * region-of-influence approach * pooling groups * extreme precipitation events * L-moments * Slovakia Subject RIV: DG - Athmosphere Sciences, Meteorology Impact factor: 2.167, year: 2008 http://www.hydrol-earth-syst-sci.net/12/825/2008/

  7. Interaction with extracellular matrix proteins influences Lsh/Ity/Bcg (candidate Nramp) gene regulation of macrophage priming/activation for tumour necrosis factor-alpha and nitrite release.

    Science.gov (United States)

    Formica, S; Roach, T I; Blackwell, J M

    1994-05-01

    The murine resistance gene Lsh/Ity/Bcg regulates activation of macrophages for tumour necrosis factor-alpha (TNF-alpha)-dependent production of nitric oxide mediating antimicrobial activity against Leishmania, Salmonella and Mycobacterium. As Lsh is differentially expressed in macrophages from different tissue sites, experiments were performed to determine whether interaction with extracellular matrix (ECM) proteins would influence the macrophage TNF-alpha response. Plating of bone marrow-derived macrophages onto purified fibrinogen or fibronectin-rich L929 cell-derived matrices, but not onto mannan, was itself sufficient to stimulate TNF-alpha release, with significantly higher levels released from congenic B10.L-Lshr compared to C57BL/10ScSn (Lshs) macrophages. Only macrophages plated onto fibrinogen also released measurable levels of nitrites, again higher in Lshr compared to Lshs macrophages. Addition of interferon-gamma (IFN-gamma), but not bacterial lipopolysaccharide or mycobacterial lipoarabinomannan, as a second signal enhanced the TNF-alpha and nitrite responses of macrophages plated onto fibrinogen, particularly in the Lshr macrophages. Interaction with fibrinogen and fibronectin also primed macrophages for an enhanced TNF-alpha response to leishmanial parasites, but this was only translated into enhanced nitrite responses in the presence of IFN-gamma. In these experiments, Lshr macrophages remained superior in their TNF-alpha responses throughout, but to a degree which reflected the magnitude of the difference observed on ECM alone. Hence, the specificity for the enhanced TNF-alpha responses of Lshr macrophages lay in their interaction with fibrinogen and fibronectin ECM, while a differential nitrite response was only observed with fibrinogen and/or IFN-gamma. The results are discussed in relation to the possible function of the recently cloned candidate gene Nramp, which has structural identity to eukaryote transporters and an N-terminal cytoplasmic

  8. 影响猪肉质的主效基因和候选基因%Progress in major and candidate genes influencing meat quality traits in pigs

    Institute of Scientific and Technical Information of China (English)

    李凤; 黄业传; 吴照明

    2012-01-01

    Abstract.. More attention was paid on meat quality by both consumers and producers. Meat quality traits influenced its economical value directly. The high development of molecular biology had stimulated people's care and accelerated their study for genes concerning meat quality. In this paper,the research advance of major genes such as hal gene, PRKAG3 gene, rendement napole gene(RN) and of candidate gene such as fat acid binding protein (FABPs),hormone-sensitive lipase gene (HSL),lipoprotein lipase gene (LPL) were reviewed.%摘要:猪肉的品质问题已经引起了生产者和消费者的普遍关注,肉质性状直接影响到肉品的食用价值和经济价值。分子生物学技术的快速发展也促进了人们对于影响肉质相关基因的重视和研究。本文综述了与肉质相关的主效基因(MajorGene)烷氟基因(Halgene)、单磷酸腺苷蛋白激酶(AMPK)γ3亚基基因(PRKAG3)和酸肉基因(RendementNapoleGene,RN)以及脂肪酸结合蛋白基因(FatAcidBindingProteinFABPs)、激素敏感脂肪酶(Hormone—SensitiveLipase.HSL)基因和脂蛋白脂肪酶(LipoproteinLipase.LPL)基因等候选基因(candidategene)的研究进展。

  9. The influence of various dielectric parameters on the reststrahlen region of SiC

    Energy Technology Data Exchange (ETDEWEB)

    Engelbrecht, J.A.A., E-mail: Japie.Engelbrecht@nmmu.ac.z [Physics Department, Nelson Mandela Metropolitan University, PO Box 77000, Port Elizabeth 6031 (South Africa); Rooyen, I.J. van [Physics Department, Nelson Mandela Metropolitan University, PO Box 77000, Port Elizabeth 6031 (South Africa); National Laser Centre, CSIR, PO Box 395, Pretoria 0001 (South Africa)

    2011-02-01

    The reststrahlen region of SiC is analysed with the goal of establishing the origin of different shapes of this band, by varying the dielectric parameters involved when simulating the reststrahlen region as obtained by infrared reflectance. -- Research highlights: {yields} An anomalous peak observed in the reststrahlen band of SiC was investigated. {yields} The reflection spectrum of SiC in the reststrahlen region was simulated by theoretical calculations. {yields} The influence on the reststrahlen band of the dielectric parameters used in the simulations is discussed. {yields} Dielectric parameters used in the simulations did not yield the anomalous peak that is observed experimentally.

  10. The influence of various dielectric parameters on the reststrahlen region of SiC

    International Nuclear Information System (INIS)

    The reststrahlen region of SiC is analysed with the goal of establishing the origin of different shapes of this band, by varying the dielectric parameters involved when simulating the reststrahlen region as obtained by infrared reflectance. -- Research highlights: → An anomalous peak observed in the reststrahlen band of SiC was investigated. → The reflection spectrum of SiC in the reststrahlen region was simulated by theoretical calculations. → The influence on the reststrahlen band of the dielectric parameters used in the simulations is discussed. → Dielectric parameters used in the simulations did not yield the anomalous peak that is observed experimentally.

  11. Individual and coupled influences of AMO and ENSO on regional precipitation characteristics and extremes

    Science.gov (United States)

    Goly, Aneesh; Teegavarapu, Ramesh S. V.

    2014-06-01

    Understanding the influences of Atlantic multidecadal oscillation (AMO) and El Niño southern oscillation (ENSO) on regional precipitation extremes and characteristics in the state of Florida is the focus of this study. Exhaustive evaluations of individual and combined influences of these oscillations using, descriptive indices-based assessment of statistically significant changes in rainfall characteristics, identification of spatially varying influences of oscillations on dry and wet spell transition states, antecedent precipitation prior to extreme events, intraevent temporal distribution of precipitation and changes in temporal occurrences of extremes including dry/wet cycles are carried out. Rain gage and gridded precipitation data analysis using parametric hypothesis tests confirm statistically significant changes in the precipitation characteristics from one phase to another of each oscillation and also in coupled phases. Spatially nonuniform and uniform influences of AMO and ENSO, respectively, on precipitation are evident. AMO influences vary in peninsular and continental parts of Florida and the warm (cool) phase of AMO contributes to increased precipitation extremes during wet (dry) season. The influence of ENSO is confined to dry season with El Niño (La Niña) contributing to increase (decrease) in extremes and total precipitation. Wetter antecedent conditions preceding daily extremes are dominant in AMO warm phase compared to the cool and are likely to impact design floods in the region. AMO influence on dry season precipitation extremes is noted for ENSO neutral years. The two oscillations in different phases modulate each other with seasonal and spatially varying impacts and implications on flood control and water supply in the region.

  12. Fine-scale linkage mapping reveals a small set of candidate genes influencing honey bee grooming behavior in response to Varroa mites.

    Directory of Open Access Journals (Sweden)

    Miguel E Arechavaleta-Velasco

    Full Text Available Populations of honey bees in North America have been experiencing high annual colony mortality for 15-20 years. Many apicultural researchers believe that introduced parasites called Varroa mites (V. destructor are the most important factor in colony deaths. One important resistance mechanism that limits mite population growth in colonies is the ability of some lines of honey bees to groom mites from their bodies. To search for genes influencing this trait, we used an Illumina Bead Station genotyping array to determine the genotypes of several hundred worker bees at over a thousand single-nucleotide polymorphisms in a family that was apparently segregating for alleles influencing this behavior. Linkage analyses provided a genetic map with 1,313 markers anchored to genome sequence. Genotypes were analyzed for association with grooming behavior, measured as the time that individual bees took to initiate grooming after mites were placed on their thoraces. Quantitative-trait-locus interval mapping identified a single chromosomal region that was significant at the chromosome-wide level (p<0.05 on chromosome 5 with a LOD score of 2.72. The 95% confidence interval for quantitative trait locus location contained only 27 genes (honey bee official gene annotation set 2 including Atlastin, Ataxin and Neurexin-1 (AmNrx1, which have potential neurodevelopmental and behavioral effects. Atlastin and Ataxin homologs are associated with neurological diseases in humans. AmNrx1 codes for a presynaptic protein with many alternatively spliced isoforms. Neurexin-1 influences the growth, maintenance and maturation of synapses in the brain, as well as the type of receptors most prominent within synapses. Neurexin-1 has also been associated with autism spectrum disorder and schizophrenia in humans, and self-grooming behavior in mice.

  13. Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies

    NARCIS (Netherlands)

    A. González-Neira (Anna); J.M. Rosa-Rosa; A. Osorio (Ana); E. Gonzalez (Emilio); M.C. Southey (Melissa); O. Sinilnikova (Olga); H. Lynch (Henry); R.A. Oldenburg (Rogier); C.J. van Asperen (Christi); N. Hoogerbrugge (Nicoline); G. Pita (G.); P. Devilee (Peter); D. Goldgar (David); J. Benítez (Javier)

    2007-01-01

    textabstractBackground: The recent development of new high-throughput technologies for SNP genotyping has opened the possibility of taking a genome-wide linkage approach to the search for new candidate genes involved in heredity diseases. The two major breast cancer susceptibility genes BRCA1 and BR

  14. Regional Influence of Aerosol Emissions from Wildfires Driven by Combustion Efficiency: Insights from the BBOP Campaign.

    Science.gov (United States)

    Collier, Sonya; Zhou, Shan; Onasch, Timothy B; Jaffe, Daniel A; Kleinman, Lawrence; Sedlacek, Arthur J; Briggs, Nicole L; Hee, Jonathan; Fortner, Edward; Shilling, John E; Worsnop, Douglas; Yokelson, Robert J; Parworth, Caroline; Ge, Xinlei; Xu, Jianzhong; Butterfield, Zachary; Chand, Duli; Dubey, Manvendra K; Pekour, Mikhail S; Springston, Stephen; Zhang, Qi

    2016-08-16

    Wildfires are important contributors to atmospheric aerosols and a large source of emissions that impact regional air quality and global climate. In this study, the regional and nearfield influences of wildfire emissions on ambient aerosol concentration and chemical properties in the Pacific Northwest region of the United States were studied using real-time measurements from a fixed ground site located in Central Oregon at the Mt. Bachelor Observatory (∼2700 m a.s.l.) as well as near their sources using an aircraft. The regional characteristics of biomass burning aerosols were found to depend strongly on the modified combustion efficiency (MCE), an index of the combustion processes of a fire. Organic aerosol emissions had negative correlations with MCE, whereas the oxidation state of organic aerosol increased with MCE and plume aging. The relationships between the aerosol properties and MCE were consistent between fresh emissions (∼1 h old) and emissions sampled after atmospheric transport (6-45 h), suggesting that biomass burning organic aerosol concentration and chemical properties were strongly influenced by combustion processes at the source and conserved to a significant extent during regional transport. These results suggest that MCE can be a useful metric for describing aerosol properties of wildfire emissions and their impacts on regional air quality and global climate. PMID:27398804

  15. Genome-wide association study of regional brain volume suggests involvement of known psychiatry candidate genes, identified new candidates for psychiatric disorders and points to potential modes of their action

    OpenAIRE

    Franke, B.; Rijpkema, M.; Arias Vasquez, A.; Veltman, J; Brunner, H.; Hagoort, P.; G. FERNANDEZ

    2010-01-01

    Though most psychiatric disorders are highly heritable, it has been hard to identify genetic risk factors involved, which are most likely of small individual effect size. A possible way to aid identification of risk genes is the use of intermediate phenotypes. These are supposed to be closer to the biological substrate(s) of the disorder than psychiatric diagnoses, and therefore less genetically complex. Intermediate phenotypes can be defined e. g. at the level of brain function and of region...

  16. Influence of a vacuum region on the stability of a high-beta screw pinch

    International Nuclear Information System (INIS)

    To ascertain the influence of a vacuum region on the stability of a high-β screw pinch, the stability properties of two confinement configurations are compared. Both configurations involve diffuse equilibrium profiles and a rigid, perfectly conducting cylindrical shell. In the first problem, perfectly conducting plasma extends to the rigid conducting wall; the plasma is extremely tenuous in the outer region of the pinch, however. In the second case, profiles identical to those of the first problem are chosen for the central portion of the pinch, but the outer tenuous plasma is replaced by a perfectly insulating vacuum region. The two configruations are found to be unstable for the same range of external parameter values; different modes are unstable in the two cases, however. Thus, the presence of a vacuum region does not affect the stability boundary of the pinch, but it does affect the nature of the unstable modes

  17. Modeling of budgetary funding influence on socio-demographic processes of a region

    Directory of Open Access Journals (Sweden)

    Aleksandra Vladimirovna Vasil'eva

    2012-06-01

    Full Text Available This paper describes a method of modeling socio-demographic processes in a region based on the minimax approach. In this method, the simulated socio-demographic processes reflect the performance of a population fertility age model, reproductive systems and the structure of mortality, as management impact tools of fiscal spending on socially significant budget items (health, physical culture and sport, social policy, education, environmental protection are considered. Testing methodology on the examples of the Russian Federation subjects included in the Ural Federal District is presented. Peculiarities of influence of funding of each socially important item on the social and demographic processes in the regions of the Ural Federal District are shown. Priorities of distribution of funds based on the level of budgetary provision in the region to ensure optimization of socio-demographic development of the region are shaped.

  18. Environmental effect and genetic influence: a regional cancer predisposition survey in the Zonguldak region of Northwest Turkey

    Science.gov (United States)

    Kadir, Selahattin; Önen-Hall, A. Piril; Aydin, S. Nihal; Yakicier, Cengiz; Akarsu, Nurten; Tuncer, Murat

    2008-03-01

    The Cretaceous-Eocene volcano-sedimentary units of the Zonguldak region of the western Black Sea consist of subalkaline andesite and tuff, and sandstone dominated by smectite, kaolinite, accessory chlorite, illite, mordenite, and analcime associated with feldspar, quartz, opal-CT, amphibole, and calcite. Kaolinization, chloritization, sericitization, albitization, Fe-Ti-oxidation, and the presence of zeolite, epidote, and illite in andesitic rocks and tuffaceous materials developed as a result of the degradation of a glass shards matrix, enclosed feldspar, and clinopyroxene-type phenocrysts, due to alteration processes. The association of feldspar and glass with smectite and kaolinite, and the suborientation of feldspar-edged, subparallel kaolinite plates to fracture axes may exhibit an authigenic smectite or kaolinite. Increased alteration degree upward in which Al, Fe, and Ti are gained, and Si, Na, K, and Ca are depleted, is due to the alteration following possible diagenesis and hydrothermal activities. Micromorphologically, fibrous mordenite in the altered units and the presence of needle-type chrysotile in the residential buildings in which cancer cases lived were detected. In addition, the segregation pattern of cancer susceptibility in the region strongly suggested an environmental effect and a genetic influence on the increased cancer incidence in the region. The most likely diagnosis was Li-Fraumeni syndrome, which is one of the hereditary cancer predisposition syndromes; however, no mutations were observed in the p53 gene, which is the major cause of Li-Fraumeni syndrome. The micromorphology observed in the altered units in which cancer cases were detected may have a role in the expression of an unidentified gene, but does not explain alone the occurrence of cancer as a primary cause in the region.

  19. Influence of the TEC fluctuations in the polar region on precise GPS positioning.

    Science.gov (United States)

    Sieradzki, Rafal; Paziewski, Jacek; Wielgosz, Pawel

    2014-05-01

    The ionospheric delay is an atmoshperic effect influencing on Global Navigation Satellite System signals. On the one hand it is a factor limiting the accuracy of the GNSS positioning, and on the other it makes satellite observations a very good source of the information on the ionospheric conditions. The degradation of the relative positioning accuracy and reliability can be connected with high gradients of the total electron content or with the TEC fluctuations. The latter of these effects mainly occurs in the equatorial and polar regions. The ionosphere near the geomagnetic poles is characterized by relatively small TEC values in comparison to the other regions. However, the connection between the magnetosphere and ionosphere systems in the polar regions allows particle precipitation and leads to very strong ionospheric dynamics. In this work, performance of the GNSS precise relative positioning under disturbed ionospheric conditions in the northern polar region is studied. The test results are based on processing 24-hour data sets from the selected permanent GPS stations located in Greenland. The studies cover several days of high and low solar activity, and also periods of a geomagnetic storm characterized by intensive TEC fluctuations. The data processing was carried out in static and kinematic modes. The GINPOS software developed at the University of Warmia and Mazury in Olsztyn was used for positioning tests. The study confirms and presents the influence of the ionospheric and geomagnetic activity in the polar region on the results in coordinate and ambiguity domains.

  20. Region-of-influence approach to a frequency analysis of heavy precipitation in Slovakia

    Directory of Open Access Journals (Sweden)

    L. Gaál

    2007-07-01

    Full Text Available The L-moment-based regionalization approach developed by Hosking and Wallis (1997 is a frequently used tool in regional frequency modeling of heavy precipitation events. The method consists of the delineation of homogeneous pooling groups with a fixed structure, which may, however, lead to undesirable step-like changes in growth curves and design value estimates in the case of a transition from one pooling group to another. Unlike the standard methodology, the region-of-influence (ROI approach does not make use of groups of sites (regions with a fixed structure; instead, each site has its own "region", i.e. a group of sites that are sufficiently similar to the site of interest. The aim of the study is to develop a version of the ROI approach, which was originally proposed in order to overcome inconsistencies involved in flood frequency analysis, for the modeling of probabilities of heavy precipitation amounts. Various settings of the distance metric and pooled weighting factors are evaluated, and a comparison with the standard regional frequency analysis over the area of Slovakia is performed. The advantages of the ROI approach are assessed by means of simulation studies. It is demonstrated that almost any setting of parameters of the ROI method yields estimates of growth curves and design values at individual sites that are superior to the standard regional and at-site estimates.

  1. Study on Influences of Large-scale Sports Events on Regional Economy

    OpenAIRE

    Qingshan Sun

    2011-01-01

    This article summarizes development of large-scale sports events and analyzes positive and negative influences of large-scale sports events on regional economic development. On that basis, the author further proposes such conclusion and suggestions to change the concept and bidding actively for holding the Olympic Games to promote innovation through competition, be established in the future and build up long term effect, etc.

  2. Turkey and the Arab Revolutions: Boundaries of Regional Power Influence in a Turbulent Middle East

    OpenAIRE

    Öniş, Ziya

    2014-01-01

    The recent Turkish involvement in the Middle East constitutes an important test case for establishing the boundaries of regional power influence in a changing global context. The AKP government in Turkey has become a major supporter of political change and democratization in the era of the Arab revolutions. Accumulating empirical evidence suggests, however, that the highly assertive and pro-active foreign policy of the AKP government in recent years has not been effective in terms of facilita...

  3. Regional Influences on Chinese Medicine Education: Comparing Australia and Hong Kong

    OpenAIRE

    Caragh Brosnan; Vincent C. H. Chung; Anthony L. Zhang; Jon Adams

    2016-01-01

    High quality education programs are essential for preparing the next generation of Chinese medicine (CM) practitioners. Currently, training in CM occurs within differing health and education policy contexts. There has been little analysis of the factors influencing the form and status of CM education in different regions. Such a task is important for understanding how CM is evolving internationally and predicting future workforce characteristics. This paper compares the status of CM education...

  4. Gravitational microlensing of quasar Broad Line Regions: the influence of fractal structures

    CERN Document Server

    Lewis, G F; Lewis, Geraint F.; Ibata, Rodrigo A.

    2006-01-01

    Recent models for the emission clouds within the Broad Line Region of quasars suggest that they are due to transient overdensities within an overall turbulent medium. If this were the case, the broad line emission would spatially appear fractal, possessing structure on a range of scales. This paper examines the influence of such fractal structure when a quasar is microlensed by a population of intervening masses. It is found that while the highest fractal levels can undergo significant microlensing magnification, when these light curves are superimposed to create an emission line profile, the resultant emission line profile remains relatively constant for physical models of the Broad Line Region. It is concluded that the detection of the possible fractal structure of Broad Line Regions via gravitational microlensing is not practical.

  5. Unusually high soil nitrogen oxide emissions influence air quality in a high-temperature agricultural region

    Science.gov (United States)

    Oikawa, P. Y.; Ge, C.; Wang, J.; Eberwein, J. R.; Liang, L. L.; Allsman, L. A.; Grantz, D. A.; Jenerette, G. D.

    2015-11-01

    Fertilized soils have large potential for production of soil nitrogen oxide (NOx=NO+NO2), however these emissions are difficult to predict in high-temperature environments. Understanding these emissions may improve air quality modelling as NOx contributes to formation of tropospheric ozone (O3), a powerful air pollutant. Here we identify the environmental and management factors that regulate soil NOx emissions in a high-temperature agricultural region of California. We also investigate whether soil NOx emissions are capable of influencing regional air quality. We report some of the highest soil NOx emissions ever observed. Emissions vary nonlinearly with fertilization, temperature and soil moisture. We find that a regional air chemistry model often underestimates soil NOx emissions and NOx at the surface and in the troposphere. Adjusting the model to match NOx observations leads to elevated tropospheric O3. Our results suggest management can greatly reduce soil NOx emissions, thereby improving air quality.

  6. Influence of international economic integration on socio-economic development of region

    Directory of Open Access Journals (Sweden)

    Yelena Leonidovna Andreyeva

    2014-09-01

    Full Text Available The hypothesis about new type’s integration processes in the world economy is made, the essence and distinctive peculiarities of these processes are determined. By the proposed groups of parameters, the comparative analysis of international economic integration (IEI within traditional integration processes (EU, NAFTA and those of new type (SCO, BRIC(S is carried out. The technique of estimation of influence of international economic integration on development of a country’s region is worked out, and the estimation of influence of international economic integration on socio-economic development of Sverdlovsk region is carried out. The movement of goods, services and factors of production (capital, work force between the region and the integration associations of traditional type and the groups of countries arisen in terms of forming integration processes of new type is analyzed. It is shown that the one of the tendencies in development of international economic integration of Sverdlovsk region during the last 12 years has been the increasing role and importance of new integration groups of countries. It is revealed that the purposeful account of this tendency can provide quantitative and qualitative shifts in external trade, foreign investments and labor migration of the region, related on the change of direction of flows: from the receivers of high-technological goods, capital, specialists from developed countries — to the supplier of manufactured goods, investments and high-qualified work force into countries of SCO and BIRC(S, what is one of the factors of providing economic safety of the region.

  7. The Influence of Traditional Customs and Practices on Girls' Secondary Education in Morogoro Region in Tanzania : A case Study

    OpenAIRE

    2012-01-01

    Abstract This study explored the influence of traditional customs and practices on secondary education of the girls in Morogoro region, in Tanzania. To do so, the study first explored the traditional customs and practices present in the area, and then investigated the influences of practices to the secondary education of girls. The study involved four secondary schools of Morogoro region, two from the rural and two from urban areas of that region. The study employed a qualitative resear...

  8. Characterization of a kinesin-related gene ATSV, within the tuberous sclerosis locus (TSC1) candidate region on chromosome 9q34

    Energy Technology Data Exchange (ETDEWEB)

    Furlong, R.A.; Zhou, Chun Yan; Ferguson-Smith, M.A.; Affara, N.A. [Univ. of Cambridge (United Kingdom)

    1996-05-01

    In the search for candidate genes for the tuberous sclerosis (TSC1) disease locus on chromosome 9q34, we have isolated an overlapping series of 22 plasmid and phage cDNA clones covering nearly 7 kb and with an open reading frame of 5070 bp encoding a protein of 1690 amino acids. The putative protein product is a member of the kinesin superfamily and is homologous to the mouse KIF1A and the Caenorhabditas elegans unc-104 genes. Both KIF1A and unc-104 function in the anterograde axonal transport of synaptic vesicles. The human homolog is therefore termed H-ATSV (axonal transporter of synaptic vesicles, HGMW-approved nomenclature ATSV). Screening of DNA from 107 tuberous sclerosis patients and 80 unaffected individuals with H-ATSV cDNA probes by pulsed-field gel electrophoresis/Southern blotting following digestion by rare-cutting methylation-sensitive restriction enzymes showed variant banding patterns in three patients with tuberous sclerosis. However, further analysis indicated that these variant fragments represent a rare polymorphism probably associated with methylation of clustered restriction sites. There is no evidence to support H-ATSV as a candidate gene for TSC1. 28 refs., 5 figs.

  9. Remote influences on freshwater flux variability in the Atlantic warm pool region

    Science.gov (United States)

    Zhang, Liping; Wang, Chunzai

    2012-10-01

    The understanding of freshwater flux variability is both scientifically and socially important. Local freshwater flux response to a large Atlantic warm pool (AWP) is excessive freshwater or negative Evaporation minus Precipitation (EmP) anomalies, whereas the response is deficient to a small AWP. However, the EmP anomalies in the AWP region are also influenced by the SST anomalies in the tropical eastern Pacific and in the tropical South Atlantic. These remote influences operate through the inter-basin mode represented by the SST gradient between the tropical North Atlantic and eastern Pacific and the Atlantic meridional mode (AMM) defined as the SST gradient between the tropical North and South Atlantic. When either of these two modes is in the negative phase, the EmP and sea surface salinity anomalies in the AWP region can be positive although the AWP is large. This indicates that the remote influences of the inter-basin mode and/or the AMM can overwhelm the local effect and induce an opposite freshwater response. Additionally, although ENSO and the AMM sometimes coincide with AWP variability, an El Niño in the preceding winter or a positive AMM in the spring does not necessarily follow a large AWP in the summer.

  10. The political culture of the Chilean Socialist Party and its influence on the nomination of Michelle Bachelet as presidential candidate in 2005

    OpenAIRE

    Urbina-Montana, Maria-Loreto

    2014-01-01

    This study develops a conceptualisation of the political cultures of the Chilean Socialist Party (PSCh) in order to understand and develop an explanation of the nomination of Michelle Bachelet as presidential candidate in 2005 which avoids the oversimplifications of existing approaches. At the theoretical level, political culture is defined from the collective action perspective conceptualising it as a framework for action (Elkin, 1993: 123). This political culture is formed by patterns for p...

  11. THE INFLUENCE OF ACCOUNTING SYSTEM AND FISCAL POLICY ON REGIONAL DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Oana Bogdan

    2014-10-01

    Full Text Available Regional development is a concept that aims at stimulating and diversifying economic activities, stimulating private sector investment and it contributes to reducing unemployment and improving living standards. To achieve these goals accounting and tax policies are necessary to allow private operators to realize taxable income, to create jobs for people and to pay taxes and contributions due to the State budget. The State must reinvest a part of the resources collected to the community in order to improve infrastructure, education and health, thus contributing to regional development. Changes in tax law and accounting adopted in Romania during 2009-2014 are regarded as tax breaks for companies created to ensure economic growth, dynamic and sustainable through efficient use of regional and local potential. In this paper we analyze the influence of the accounting and fiscal system on the regional development given that these measures do not always achieve their objectives established companies having benefit from the application of various tax measures. The paper will present the main changes of the tax and accounting systems and their impact on the regional development in Romania and the consequences resulting in implementing these measures.

  12. Influence of the deposition parameters on the transition region of hydrogenated silicon films growth

    Institute of Scientific and Technical Information of China (English)

    Lei Qing-Song; Wu Zhi-Meng; Geng Xin-Hua; Zhao Ying; Xi Jian-Ping

    2005-01-01

    Hydrogenated microcrystalline and amorphous silicon thin films were prepared by very high frequency plasmaenhanced chemical vapour deposition (VHF PECVD) by using a mixture of silane and hydrogen as source gas. The influence of deposition parameters on the transition region of hydrogenated silicon films growth was investigated by varying the silane concentration (SC), plasma power (Pw), working pressure (P), and substrate temperature (Ts).Results suggest that SC and Ts are the most critical factors that affect the film structure transition from microcrystalline to amorphous phase. A narrow region in the range of SC and Ts, in which the rapid phase transition takes place, was identified. It was found that at lower P or higher Pw, the transition region is shifted to larger SC. In addition, the dark conductivity and photoconductivity decrease with SC and show sharp changes in the transition region. It proposed that the transition process and the transition region are determined by the competition between the etching effect of atomic hydrogen and the growth of amorphous phase.

  13. NUMERICAL SIMULATION OF INFLUENCE OF INDIAN OCEAN SSTA ON WEATHER AND CLIMATE IN ASIAN MONSOON REGION

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Sea surface temperature anomaly (SSTA) exerts great influence on the generation of global weather and climate. Much progress has been made with respect to SSTA in the Pacific Ocean region in contrast to the Indian Ocean. The IAP9L model, which is developed at the Institute of Atmospheric Physics of the Chinese Academy of Science, is used to simulate the influence of the Indian Ocean SSTA on the general circulation and weather/climate anomalies in the monsoon region of Asia. It is found that the warm (cool) SSTA in the equatorial low latitudes of the Indian Ocean triggers winter (summer) teleconnection patterns in middle and higher latitudes of the Northern Hemisphere that are similar to PNA or EAP. They play a very important role in the anomaly of circulation or weather and climate in the middle and lower latitudes of the Asian summer monsoon region. With the warm (cool) SSTA forcing in the Indian Ocean, the Asian summer monsoon sets up at a late (early) date and withdraws at a early (late) date, lasting for a short (long) duration at a weak (strong) intensity. The Indian Ocean SSTA is shown to be an indicator for precipitation variation in China.

  14. Regional watershed evaluation of influences on stream biogeochemistry in southeastern Alaska

    Science.gov (United States)

    D'Amore, D. V.; Edwards, R.; Biles, F. E.; Fellman, J. B.

    2005-12-01

    Characterization of individual watershed types at regional scales has been a goal of many organizations. Broad regional approaches have attempted to use watershed information to guide environmental analysis or prediction, but regional assessments rely on extensive historical data. Southeast Alaska, which is mostly under the management of the Tongass National Forest, has extensive vegetation and soil information, but no comprehensive information on stream discharge, nutrient chemistry or biogeochemical measurements across the landscape. The Tongass Forest is larger than West Virginia, contains thousands of anadramous salmonid reaches, spans 6 degrees of latitude and is undergoing significant climate changes. Anticipating climate change effects or responses to timber harvest or other management requires a much better understanding of existing natural variability and what watershed characteristics drive biogeochemical cycles. We report results of a regional watershed evaluation using a statistically based synoptic sampling designed to determine what physical and biological features influence stream chemistry over the entire Tongass. Sixty-one watersheds across the Tongass were randomly chosen in two broad classes: wetland dominated watersheds (>50% wetland by area), and non-wetland watersheds (history, and ecoregional classification. DOC concentrations in stream water were significantly related to the wetland extent in the watershed, which explained nearly 25% of the variability among sampled watersheds in the region. This confirms the hypothesis that wetland soil processes exert an important influence on stream chemistry in the temperate rainforest of southeast Alaska independent of all other variables known to influence DOC concentration. When latitude, harvest history, and watershed size were included in the analysis the model explained about half of the variation in DOC concentration among watersheds. Analysis of variance with DOC concentration versus ecological

  15. Influence of stellar multiplicity on planet formation. I. Evidence of suppressed planet formation due to stellar companions within 20 au and validation of four planets from the Kepler multiple planet candidates

    International Nuclear Information System (INIS)

    The planet occurrence rate for multiple stars is important in two aspects. First, almost half of stellar systems in the solar neighborhood are multiple systems. Second, the comparison of the planet occurrence rate for multiple stars to that for single stars sheds light on the influence of stellar multiplicity on planet formation and evolution. We developed a method of distinguishing planet occurrence rates for single and multiple stars. From a sample of 138 bright (KP < 13.5) Kepler multi-planet candidate systems, we compared the stellar multiplicity rate of these planet host stars to that of field stars. Using dynamical stability analyses and archival Doppler measurements, we find that the stellar multiplicity rate of planet host stars is significantly lower than field stars for semimajor axes less than 20 AU, suggesting that planet formation and evolution are suppressed by the presence of a close-in companion star at these separations. The influence of stellar multiplicity at larger separations is uncertain because of search incompleteness due to a limited Doppler observation time baseline and a lack of high-resolution imaging observation. We calculated the planet confidence for the sample of multi-planet candidates and find that the planet confidences for KOI 82.01, KOI 115.01, KOI 282.01, and KOI 1781.02 are higher than 99.7% and thus validate the planetary nature of these four planet candidates. This sample of bright Kepler multi-planet candidates with refined stellar and orbital parameters, planet confidence estimation, and nearby stellar companion identification offers a well-characterized sample for future theoretical and observational study.

  16. Climate Variability is Influencing Agricultural Expansion and Output in a Key Agricultural Region of Brazil

    Science.gov (United States)

    Spera, S. A.; Cohn, A.; VanWey, L.; Mustard, J. F.

    2013-12-01

    Over the last decade, the Brazilian state of Mato Grosso has both expanded and intensified its agricultural production to become the country's leading producer of soy, corn, and cotton. Yet this increase in agricultural production may be threatened due to changes in the region's climate stemming from deforestation caused by the agricultural expansion itself. The sensitivity of Mato Grosso's agriculture to climate variability has important implications for both climate change mitigation and climate adaptation. The vast bulk of research on the drivers of land use change in the region has examined economic and institutional drivers. Leveraging a novel remote sensing-derived dataset classifying shifts between single (cultivating one commercial crop per growing season) and double cropping (cultivating two commercial crops per growing season), we investigated the influence of climate variability on land use change during the period 2000 to 2011. Over the past decade, over half of Mato Grosso's farm area transitioned from single cropping to double cropping. We used regression analysis (controlling for space and time fixed effects) to show monthly rainfall, monthly temperature, agricultural commodity prices, and agricultural revenue to be the main drivers of adoption of double cropping and reversion to single cropping in the region. The influence of climate varies as much as five orders of magnitude across these outcomes, with both temperature and precipitation exhibiting the largest climatic influence on the transition from single to double cropping. Temperature consistently proves to be more important, explaining three times more of the variance than precipitation for each outcome. Months at the beginning of a given first crop season, the end of that first crop season, and middle of the subsequent second crop season are particularly important for planting decisions in the subsequent growing year. Fitting our land transition models using remote-sensing derived

  17. The influence of parents on cohabitation in Italy - Insights from two regional contexts

    Directory of Open Access Journals (Sweden)

    Christin Schröder

    2008-09-01

    Full Text Available In view of the demographic changes that affect all European countries, the diffusion of new living arrangements such as non-marital cohabitation is particularly interesting. In this article we concentrate on Italy, a country that is characterized by a low pace in the diffusion of cohabitation. Earlier studies found statistical evidence of the impact of parents' characteristics on young adults' decisions for cohabitation. However, there is only limited empirical knowledge about the actual mechanism through which parents influence the choices of their children. We employ qualitative research methods and focus on two regional contexts in order to analyze if and how parents intervene in the choices of young adults.

  18. Influence of industria l enterprises on ecological and economic safety of a region

    Directory of Open Access Journals (Sweden)

    Aleksandr Bezkorovayniy

    2014-04-01

    Full Text Available Current problems of influence of machine-building enterprises on the environment of Ukraine and the main factors and ways of providing of stableecological and economic development of a region are considered in the article. The machinery engineering is a diversified industry that includesheavy, electrical and technical, radio and electrical, transport engineering. Own ecological peculiarities are inherent to each of the branches,among which are content and quantity of waste, toxicity of pollutions, and a regime of their emission to the atmosphere. The machinery engineeringas well as other industries is accommodated in regions of development of the metallurgy, concentrated in cities, and “produces» considerableamounts of waste, which pollutes the air, water, and the soil. A particular harmful influence on the environment is typical for the majority of typesof a business activity. Some engineering enterprises in the process of their functioning produce significant quantity of substances that pollute theenvironment. This is related with mechanical wear and obsolescence of technologies and equipment used by the enterprises. The author revealedthe main ways of providing of stable ecological and economic development of both a region and a state, among which are balanced development ofregions, creation of regional committees of stable development of cities, districts, and regions, change of the policy of usage of natural, labor, andother resources of our state by the developed countries, development of high-tech productions, membership of Ukraine in different internationaleconomic and political organizations, improvement of the ecological legislation of Ukraine and adoption of the Ecological code, implementation ofecological insurance, enhancement of the economic and finance mechanism of realization of the national ecological and economic policy of stabledevelopment, extension of ecological education, and realization of projects on developing natural

  19. Genomic scan of selective sweeps in thin and fat tail sheep breeds for identifying of candidate regions associated with fat deposition

    Directory of Open Access Journals (Sweden)

    Moradi Mohammad Hossein

    2012-02-01

    Full Text Available Abstract Background Identification of genomic regions that have been targets of selection for phenotypic traits is one of the most important and challenging areas of research in animal genetics. However, currently there are relatively few genomic regions identified that have been subject to positive selection. In this study, a genome-wide scan using ~50,000 Single Nucleotide Polymorphisms (SNPs was performed in an attempt to identify genomic regions associated with fat deposition in fat-tail breeds. This trait and its modification are very important in those countries grazing these breeds. Results Two independent experiments using either Iranian or Ovine HapMap genotyping data contrasted thin and fat tail breeds. Population differentiation using FST in Iranian thin and fat tail breeds revealed seven genomic regions. Almost all of these regions overlapped with QTLs that had previously been identified as affecting fat and carcass yield traits in beef and dairy cattle. Study of selection sweep signatures using FST in thin and fat tail breeds sampled from the Ovine HapMap project confirmed three of these regions located on Chromosomes 5, 7 and X. We found increased homozygosity in these regions in favour of fat tail breeds on chromosome 5 and X and in favour of thin tail breeds on chromosome 7. Conclusions In this study, we were able to identify three novel regions associated with fat deposition in thin and fat tail sheep breeds. Two of these were associated with an increase of homozygosity in the fat tail breeds which would be consistent with selection for mutations affecting fat tail size several thousand years after domestication.

  20. [Influence of the technogenic environment on health new-borns infant children in Lugansk region].

    Science.gov (United States)

    Kapranov, S V; Sapel'nikov, A Ia; Sapel'nikova, L Ia

    2014-01-01

    The aim of the work was to evaluate the health of new-borns born to mothers who lived constantly influenced of the technogenic environmentat on health infant children in Luhansk region. We exameded evaluation of the influence of the technogenic environmental factors on the health of 1119 children in Alchevsk city, Perevalsk town with mining towns and rural villages of Perevalsky area of Lugansk region and Zhovtnev district of Lugansk region. The children were measured in anthropometric studies conducted body length, body weight, chest circumference and the head. Evaluation of the physical development of the children carried tsentilnym method. Prior to discharge from the hospital new-borns divided into three main groups--healthy, risk group, pathology. Also we have done the analysis of the statistical information on the health status of all newborns administrative units Lugansk region. Found that the percentage of new-borns with normal anthropometric variables (from 3 to 97 centile), body length and head circumference was significantly higher in rural areas Perevalsky area with more favorable environmental conditions compared to the industrial city of Alchevsk. New-borns with abnormal significantly higher in women who are domiciled in the city of Alchevsk (19.01% ± 1.44%) under the impact of emissions components ferrous metallurgy and coke-chemical, compared with Perevalskiy and mining towns (13.82% ± 2.20%), as well as rural villages Perevalsky area (11.90% ± 2.89%). Over the period 2004-2011, the incidence of congenital anomalies of new-borns weighing 1000 g or more (per 1000 live births and stillbirths) were significantly higher in the industrial cities of Luhansk region--19.70 ± 0.61 compared with rural areas--15.51 ± 0.73. The incidence of this pathology is one of the highest in Alchevsk--31.88 ± 2.48, which was significantly higher than.in urban areas, as well as in the whole of Luhansk region--19.13 ± 0.55. Therefore, the health of new-born babies is

  1. The study of mutations of high penetrates candidate genes, participating in appearance of breast cancer in patients from different regions of Belarus

    International Nuclear Information System (INIS)

    Breast cancer is the most common lethal malignancy of women all over the world. Despite considerable efforts, many predisposing factors remain poorly defined. Epidemiological studies have shown that higher age and a positive family history of breast cancer are associated with the highest risk. Familial clustering of breast cancer, often in conjunction with cancer at other sites, is frequently caused by a hereditary disposition. Known genes with a high penetrance such as BRCA1 and BRCA2. Hereditary and environmental factors may have acted synergistically in many breast cancer cases, and a number of environmental factors may modulate the probability and progression of the disease. Ionizing radiation is for long being recognized as a potent carcinogen. The purpose of this paper is to study mutations of high penetrate candidate genes, participating in appearance of breast cancer in Byelorussian patients. This study is for the first time reveals the mutations of breast cancer genes in the Byelorussian population. Were used such methods as extraction of DNA, PCR and restriction analysis for this study. As a result of the work frequent mutations of BRCA1 and BRCA2 were found in family cases. It is shown that following methods are useful for cancer risk prediction for patients and their blood relatives. (authors)

  2. Sequencing of a QTL-rich region of the Theobroma cacao genome using pooled BACs and the identification of trait specific candidate genes

    Directory of Open Access Journals (Sweden)

    Blackmon Barbara P

    2011-07-01

    Full Text Available Abstract Background BAC-based physical maps provide for sequencing across an entire genome or a selected sub-genomic region of biological interest. Such a region can be approached with next-generation whole-genome sequencing and assembly as if it were an independent small genome. Using the minimum tiling path as a guide, specific BAC clones representing the prioritized genomic interval are selected, pooled, and used to prepare a sequencing library. Results This pooled BAC approach was taken to sequence and assemble a QTL-rich region, of ~3 Mbp and represented by twenty-seven BACs, on linkage group 5 of the Theobroma cacao cv. Matina 1-6 genome. Using various mixtures of read coverages from paired-end and linear 454 libraries, multiple assemblies of varied quality were generated. Quality was assessed by comparing the assembly of 454 reads with a subset of ten BACs individually sequenced and assembled using Sanger reads. A mixture of reads optimal for assembly was identified. We found, furthermore, that a quality assembly suitable for serving as a reference genome template could be obtained even with a reduced depth of sequencing coverage. Annotation of the resulting assembly revealed several genes potentially responsible for three T. cacao traits: black pod disease resistance, bean shape index, and pod weight. Conclusions Our results, as with other pooled BAC sequencing reports, suggest that pooling portions of a minimum tiling path derived from a BAC-based physical map is an effective method to target sub-genomic regions for sequencing. While we focused on a single QTL region, other QTL regions of importance could be similarly sequenced allowing for biological discovery to take place before a high quality whole-genome assembly is completed.

  3. Microbial diversity of a Brazilian coastal region influenced by an upwelling system and anthropogenic activity.

    Directory of Open Access Journals (Sweden)

    Juliano C Cury

    Full Text Available BACKGROUND: Upwelling systems are characterised by an intense primary biomass production in the surface (warmest water after the outcrop of the bottom (coldest water, which is rich in nutrients. Although it is known that the microbial assemblage plays an important role in the food chain of marine systems and that the upwelling systems that occur in southwest Brazil drive the complex dynamics of the food chain, little is known about the microbial composition present in this region. METHODOLOGY/PRINCIPAL FINDINGS: We carried out a molecular survey based on SSU rRNA gene from the three domains of the phylogenetic tree of life present in a tropical upwelling region (Arraial do Cabo, Rio de Janeiro, Brazil. The aim was to analyse the horizontal and vertical variations of the microbial composition in two geographically close areas influenced by anthropogenic activity (sewage disposal/port activity and upwelling phenomena, respectively. A lower estimated diversity of microorganisms of the three domains of the phylogenetic tree of life was found in the water of the area influenced by anthropogenic activity compared to the area influenced by upwelling phenomena. We observed a heterogenic distribution of the relative abundance of taxonomic groups, especially in the Archaea and Eukarya domains. The bacterial community was dominated by Proteobacteria, Cyanobacteria and Bacteroidetes phyla, whereas the microeukaryotic community was dominated by Metazoa, Fungi, Alveolata and Stramenopile. The estimated archaeal diversity was the lowest of the three domains and was dominated by uncharacterised marine Crenarchaeota that were most closely related to Marine Group I. CONCLUSIONS/SIGNIFICANCE: The variety of conditions and the presence of different microbial assemblages indicated that the area of Arraial do Cabo can be used as a model for detailed studies that contemplate the correlation between pollution-indicating parameters and the depletion of microbial

  4. Two new cases with microdeletion of 17q23.2 suggest presence of a candidate gene for sensorineural hearing loss within this region

    DEFF Research Database (Denmark)

    Schönewolf-Greulich, Bitten; Ronan, Anne; Ravn, Kristine;

    2011-01-01

    Microdeletion of the 17q23.2 region has very recently been suggested as a new emerging syndrome based on the finding of 8 cases with common phenotypes including mild-to-moderate developmental delay, heart defects, microcephaly, postnatal growth retardation, and hand, foot, and limb abnormalities...

  5. Attenuation corrected myocardial PET using post injection transmission measurement: influence on relative regional uptake values

    International Nuclear Information System (INIS)

    Aim: Post injection transmission measurement (PIT) can be performed using rotating 68Ge/68Ga linesources. This study estimates attenuation coefficients, count densities and relative regional uptake values of PIT corrected cardiac PET (E-PIT) compared to routinely pre-injection transmission measurement (RT). Methods: A thorax-phantom with homogeneously filled myocardium or with simulated defects and six patients with advanced coronary artery disease were studied using ECAT Exact tomography (Siemens CTI) equipped with three rotating linesources. Transmission was performed twice (PIT, RT), attenuation coefficients and emission data were analysed, the latter without attenuation correction (E-UK), corrected with PIT (E-PIT) and with RT (E-RT) (count density, standard and relative uptake values). Results: Both in phantom and patient studies attenuation coefficients differed significantly between PIT and RT. Comparing E-PIT and E-RT, regional uptake values were different only in phantom simulation with myocardial radioactivity concentrations higher than 10 kBqxml-1. The image contrast between defects and remaining myocardium in the phantom studies or the standard and relative uptake values in patient studies did not vary significantly. Conclusion: Under clinical conditions a post injection transmission measurement does not influence the accuracy of regional myocardial uptake values relevantly. (orig.)

  6. Lifelong Learning and Employability in the Danube Region Countries: Influences and Correlations

    Directory of Open Access Journals (Sweden)

    Constanţa-Nicoleta Bodea

    2016-08-01

    Full Text Available A continuous challenge for education and lifelong learning is to assist individuals in acquiring skills and knowledge for successful work life, especially after the financial crisis which influenced negatively the employment growth in all European Union countries. The paper focuses on finding correlations between employability and lifelong learning in the Danube Region countries of the European Union and more explicitly in the ex-communist ones of this region. As research instruments, two online questionnaires were built based on a thorough literature review and a set of structured interviews and filled in by 390 IT students and 55 IT professors. The surveys’ results revealed a clear positive correlation between the level of education and the opinion about the importance of obtaining a job as a result of the educational endeavors. A special attention in the survey was given to social networks, which were acknowledged as modern facilitators of lifelong learning activities. The conclusions of the current study are particularly important in the Romanian context, as the employment rate of recent graduates is in a decreasing trend, but also for all the Danube Region ex-communist countries, which have to boost their employment rates as well, to assure their economical growth. Identification of factors stimulating employment of young people according with their education contributes at the sustainable economic growth of these countries, at the growth of graduates insertion in the labor market and at the diminution of labor migration.

  7. Lake breezes in the southern Great Lakes region and their influence during BAQS-Met 2007

    Directory of Open Access Journals (Sweden)

    D. M. L. Sills

    2011-02-01

    Full Text Available Mesoscale observations from the BAQS-Met field experiment during the summer of 2007 were integrated and manually analyzed in order to identify and characterize lake breezes in the southern Great Lakes region of North America, and assess their potential impact on air quality. Lake breezes were found to occur on 90% of study days, often occurring in conditions previously thought to impede their development. They affected all parts of the study region, including southwestern Ontario and nearby portions of southeast Michigan and northern Ohio, occasionally penetrating inland from 100 km to over 200 km. Occurrence rates and penetration distances were found to be higher than previously reported in the literature. This more accurate depiction of observed lake breezes allows a better understanding of their influence on the production and transport of pollutants in this region.

    The observational analyses were compared with output from subsequent runs of a high-resolution numerical weather prediction model. The model accurately predicted lake breeze occurrence in a variety of synoptic wind regimes, but selected cases showed substantial differences in the detailed timing and location of lake-breeze fronts, and with the initiation of deep moist convection. Knowledge of such strengths and weaknesses will assist with interpretation of results from air quality modelling driven by this meteorological model.

  8. Lake breezes in the southern Great Lakes region and their influence during BAQS-Met 2007

    Directory of Open Access Journals (Sweden)

    D. M. L. Sills

    2011-08-01

    Full Text Available Meteorological observations from the BAQS-Met field experiment during the summer months of 2007 were integrated and manually analyzed in order to identify and characterize lake breezes in the southern Great Lakes region of North America, and assess their potential impact on air quality. Lake breezes occurred frequently, with one or more lake breezes identified on 90 % of study days. They affected all parts of the study region, including southwestern Ontario and nearby portions of southeast Lower Michigan and northern Ohio, with lake-breeze fronts occasionally penetrating from 100 km to over 200 km inland. Occurrence rates and penetration distances were found to be higher than previously reported in the literature. This comprehensive depiction of observed lake breezes allows an improved understanding of their influence on the transport, dispersion, and production of pollutants in this region.

    The observational analyses were compared with output from subsequent runs of a high-resolution numerical weather prediction model. The model accurately predicted lake breeze occurrence and type in a variety of synoptic wind regimes, but selected cases showed substantial differences in the detailed timing and location of lake-breeze fronts, and with the initiation of deep moist convection. Knowledge of such strengths and weaknesses aids in the interpretation of results from air quality models driven by this meteorological model.

  9. The influence of long-term low temperature aging on the performance of candidate high-nickel alloys for the nuclear waste repository

    International Nuclear Information System (INIS)

    The phase stability of candidate alloys under repository-relevant conditions is a critical issue that will have an impact on the long-term mechanical and corrosion properties of the metal barrier. For waste packages with the highest thermal outputs, the surface temperature of the containers will rise to a peak temperature of about 250 C. After 100 years the temperature will drop to about 150 C and will continue dropping slowly. This paper discusses the metallurgical phase stability in terms of precipitation and ordering behavior of Ni-Cr-Mo-W alloys after long term aging at temperatures below 550 C. In addition, the effect of low temperature aging on the mechanical and corrosion properties is presented. Charpy impact testing and tensile testing have been used to evaluate the effect of aging on mechanical properties. The corrosion resistance has been assessed using standard ASTM G28A and B test methods

  10. The influence of spectral nudging on typhoon formation in regional climate models

    International Nuclear Information System (INIS)

    Regional climate models can successfully simulate tropical cyclones and typhoons. This has been shown and was evaluated for hindcast studies of the past few decades. But often global and regional weather phenomena are not simulated at the observed location, or occur too often or seldom even though the regional model is driven by global reanalysis data which constitute a near-realistic state of the global atmosphere. Therefore, several techniques have been developed in order to make the regional model follow the global state more closely. One is spectral nudging, which is applied for horizontal wind components with increasing strength for higher model levels in this study. The aim of this study is to show the influence that this method has on the formation of tropical cyclones (TC) in regional climate models. Two ensemble simulations (each with five simulations) were computed for Southeast Asia and the Northwestern Pacific for the typhoon season 2004, one with spectral nudging and one without. First of all, spectral nudging reduced the overall TC number by about a factor of 2. But the number of tracks which are similar to observed best track data (BTD) was greatly increased. Also, spatial track density patterns were found to be more similar when using spectral nudging. The tracks merge after a short time for the spectral nudging simulations and then follow the BTD closely; for the no nudge cases the similarity is greatly reduced. A comparison of seasonal precipitation, geopotential height, and temperature fields at several height levels with observations and reanalysis data showed overall a smaller ensemble spread, higher pattern correlations and reduced root mean square errors and biases for the spectral nudged simulations. Vertical temperature profiles for selected TCs indicate that spectral nudging is not inhibiting TC development at higher levels. Both the Madden–Julian Oscillation and monsoonal precipitation are reproduced realistically by the regional model

  11. The influence of spectral nudging on typhoon formation in regional climate models

    Science.gov (United States)

    Feser, Frauke; Barcikowska, Monika

    2012-03-01

    Regional climate models can successfully simulate tropical cyclones and typhoons. This has been shown and was evaluated for hindcast studies of the past few decades. But often global and regional weather phenomena are not simulated at the observed location, or occur too often or seldom even though the regional model is driven by global reanalysis data which constitute a near-realistic state of the global atmosphere. Therefore, several techniques have been developed in order to make the regional model follow the global state more closely. One is spectral nudging, which is applied for horizontal wind components with increasing strength for higher model levels in this study. The aim of this study is to show the influence that this method has on the formation of tropical cyclones (TC) in regional climate models. Two ensemble simulations (each with five simulations) were computed for Southeast Asia and the Northwestern Pacific for the typhoon season 2004, one with spectral nudging and one without. First of all, spectral nudging reduced the overall TC number by about a factor of 2. But the number of tracks which are similar to observed best track data (BTD) was greatly increased. Also, spatial track density patterns were found to be more similar when using spectral nudging. The tracks merge after a short time for the spectral nudging simulations and then follow the BTD closely; for the no nudge cases the similarity is greatly reduced. A comparison of seasonal precipitation, geopotential height, and temperature fields at several height levels with observations and reanalysis data showed overall a smaller ensemble spread, higher pattern correlations and reduced root mean square errors and biases for the spectral nudged simulations. Vertical temperature profiles for selected TCs indicate that spectral nudging is not inhibiting TC development at higher levels. Both the Madden-Julian Oscillation and monsoonal precipitation are reproduced realistically by the regional model

  12. Systematic characterisation of disease associated balanced chromosome rearrangements by FISH: cytogenetically and genetically anchored YACs identify microdeletions and candidate regions for mental retardation genes

    DEFF Research Database (Denmark)

    Wirth, J; Nothwang, H G; van der Maarel, S;

    1999-01-01

    average one per 3 cM, spaced over the entire human genome. By fluorescence in situ hybridisation (FISH), we have performed a systematic search for YACs spanning translocation breakpoints. Patients with DBCRs and either syndromic or non-syndromic mental retardation (MR) were ascertained through the...... of disease in seemingly balanced chromosome rearrangements that are associated with a disease phenotype. Our region specific FISH probes, which are available to MCN members, can be a powerful tool in clinical cytogenetics and positional cloning....

  13. Sediment trace metal profiles in lakes of Killarney Park, Canada from regional to continental influence

    International Nuclear Information System (INIS)

    The lakes in Killarney Provincial Park (KPP) located 40-60 km southwest of Sudbury, Ontario are beginning to recover after decades of being severely affected by acidification and atmospheric pollutants. Detailed profiles of acid-recoverable trace elements (As. Cd, Cu, Co. Fe, Mn, Ni, Pb and Zn) were obtained after aqua regia digestion and ICP-OES analysis of sediment cores taken from six Park lakes. Results permitted the identification of two types of profiles. The first type applies to elements such as Fe, Mn, As and Co for which historical deposition and recent recovery are strongly masked by diagenetic remobilization. The second type of profile applies to elements such as Cd, Cu, Ni, Pb and Zn on which the history of industrialisation in North America and mining activities in Sudbury can be superimposed. Based on sediment data of trace elements less affected by diagenetic remobilization (Cd, Cu, Ni, Pb, Zn), chemical recovery indices can be estimated from depth profiles. Indices of maximum (Cp) and surface (Cs) contamination were calculated by dividing the concentration of a given metal by the pre-industrial level. The ratio of the two indices provided a simple estimation of the chemical recovery of lakes that does not consider the influence of the watershed or the lake pH. Profiles of metals in sediment of KPP complement the water quality monitoring data and tend to indicate that this area is in transition from dominant influence of regional pollution sources to becoming controlled by continental atmospheric deposition. - Lakes in Killarney Park are in transition from being impacted by regional pollution to being controlled by continental atmospheric deposition

  14. The influence of regional basic science campuses on medical students' choice of specialty and practice location: a historical cohort study

    OpenAIRE

    Brokaw James J; Mandzuk Christina A; Wade Michael E; Deal Dennis W; Johnson Mary T; White Gary W; Wilson Jeffrey S; Zollinger Terrell W

    2009-01-01

    Abstract Background Indiana University School of Medicine (IUSM) employs eight regional basic science campuses, where half of the students complete their first two years of medical school. The other half complete all four years at the main campus in Indianapolis. The authors tested the hypothesis that training at regional campuses influences IUSM students to pursue primary care careers near the regional campuses they attended. Methods Medical school records for 2,487 graduates (classes of 198...

  15. Analysis of Toxoplasma gondii Repeat Region 529 bp (NCBI Acc. No. AF146527 as a Probe Candidate for Molecular Diagnosis of Toxoplasmosis

    Directory of Open Access Journals (Sweden)

    Dyah Ayu Oktavianie A Pratama

    2015-11-01

    Full Text Available generated by an Adobe application 11.5606             Toxoplasmosis is a disease caused by protozoan parasite Toxoplasma gondii. The infection is commonly asymptomatic. The availability of confirmative and accurate detection system is really needed. This research was aimed to develop a molecular diagnosis based on the conserved and high copy number repeat region of Toxoplasma gondii with hibridization method. Nucleic acid was isolated from tachyzoites. The repeat region of T. gondii was amplified using PuRe Taq Ready To Go-PCR Beads (Amersham Bioscience,  forward primer 5’- GAC TCG GGC CCA GCT GCG  -3’ and reverse primer 5’- CCT CTC CTA CCC CTC CTC -3’. The amplicon was sequenced using ABI Prism 3100-Avant Genetic Analyzer (PT. Charoen Pokphand, Jakarta. Probe was labeled using digoxigenin-11-dUTP. Application of probe to detect it’s complementary nucloeic acid was done by hibridization method. The research concluded that probe toxo-103 bp was highly homolog with several strain of T. gondii and it has no homology either with host’s genome or other parasites which have close genetic relationship with T. gondii.   Hybridization analysis showed that probe could detect the complementary nucleic acid up to 10 ng/ul concentration.       Normal 0 36 false false false

  16. Simultaneous Factor Analysis of Coupled Aerosol and VOC Mass Spectra in Regions of Biogenic Influence

    Science.gov (United States)

    Slowik, Jay; Chang, Rachel; Hayden, Katherine; Li, Shao-Meng; Liggio, John; Sjostedt, Steven; Vlasenko, Alexander; Leaitch, Richard; Abbatt, Jonathan

    2010-05-01

    Recent studies suggest that the traditional binary treatments of atmospheric organics as either gases or particles may be inadequate, highlighting the need for analytical techniques capable of simultaneously considering particle and gas-phase species. Organic mass spectra of particles and volatile organic compounds (VOCs) were collected using an Aerodyne time-of-flight aerosol mass spectrometer (C-ToF-AMS), and a proton transfer reaction-mass spectrometer (PTR-MS), respectively. The particle and VOC mass spectra were combined into a single dataset, which was analyzed using the positive matrix factorization (PMF) receptor modeling technique. The relative weights of the AMS and PTR-MS data were balanced in the PMF analysis according to the criteria that the scaled residuals within a solution be independent of the measuring instrument. Instrument relative weight is controlled by the application of a scaling factor to the PTR-MS uncertainties. The AMS and PTR-MS instruments were deployed from mid-May to mid-June at two sites in Canada: (1) Egbert, ON (2007), a semirural site ~70 km north of Toronto, and (2) Whistler, BC (2008), a remote site ~120 km north of Vancouver. The Egbert site is influenced by anthropogenic emissions from Toronto and populated regions to the south, biogenic emissions from boreal forests to the north, and biomass burning emissions. The Whistler site is strongly influenced by boreal forest terpene emissions, with lesser contributions from long-range transport and anthropogenic emissions.

  17. Refinement of the Citrus tristeza virus resistance gene (Ctv) positional map in Poncirus trifoliata and generation of transgenic grapefruit (Citrus paradisi) plant lines with candidate resistance genes in this region.

    Science.gov (United States)

    Rai, Mamta

    2006-06-01

    Citrus tristeza virus (CTV) is a major pathogen of Citrus. A single dominant gene Ctv present in the trifoliate relative of Citrus, Poncirus trifoliata confers broad spectrum resistance against CTV. Refinement of genetic maps has delimited this gene to a 121 kb region, comprising of ten candidate Ctv resistance genes. The ten candidate genes were individually cloned in Agrobacterium based binary vector and transformed into three CTV susceptible grapefruit varieties. Two of the candidate R-genes, R-2 and R-3 are exclusively expressed in transgenic plants and in Poncirus trifoliata, while five other genes are also expressed in non-transformed Citrus controls. Northern blotting with a CTV derived probe for assessment of infection in virus inoculated plants over a span of three growth periods, each comprising of six to eight weeks, indicates either an absence of initiation of infection or it's slow spread in R-2 plant lines or an initial appearance of infection and it's subsequent obliteration in some R-1 and R-4 plant lines. Limited genome walk up- and downstream form R-1 gene, based on it's 100% sequence identity between Poncirus and Citrus, indicates promoter identity of 92% between the two varieties. Further upstream and downstream sequencing indicates the presence of an O-methyl transferase and a Copia like gene respectively in Citrus instead of the amino acid transporter like gene upstream and a sugar transporter like gene downstream in Poncirus. The possibility of recombinations in the resistance locus of Citrus and the need for consistent monitoring for virus infection and gene expression in the transgenic Citrus trees is discussed. PMID:16830176

  18. Influences of updated land-use datasets on WRF simulations for two Austrian regions

    Science.gov (United States)

    Schicker, Irene; Arnold Arias, Dèlia; Seibert, Petra

    2016-06-01

    Numerical simulations were carried out with the weather research and forecasting model to study the influence of different land-use datasets for two Austrian regions, the high-alpine Inn Valley area and the hilly Vienna Basin area. The three land-use datasets used were USGS, MODIS and a reclassified European dataset based on the CORINE CLC06 data. Simulations covered an episode in July 2007 applying a resolution of 0.8 km. Results were compared with surface observation data, radiosoundings, and satellite data. It was found that land-use both in the original CLC06 and the version where it had been reclassified to USGS classes for use in WRF was significantly more realistic than the built-in land-use datasets (USGS and MODIS). Synoptic processes during the episode considered were reproduced well by all simulations, where CLC06 and MODIS improved the model performance in both regions in terms of the surface temperatures and other meteorological parameters.

  19. The length of a lantibiotic hinge region has profound influence on antimicrobial activity and host specificity

    Directory of Open Access Journals (Sweden)

    Liang eZhou

    2015-01-01

    Full Text Available Lantibiotics are ribosomally synthesized (methyllanthionine containing peptides which can efficiently inhibit the growth of Gram-positive bacteria. As lantibiotics kill bacteria efficiently and resistance to them is difficult to be obtained, they have the potential to be used in many applications, e.g. in pharmaceutical industry or food industry. Nisin can inhibit the growth of Gram-positive bacteria by binding to lipid II and by making pores in their membrane. The C-terminal part of nisin is known to play an important role during translocation over the membrane and forming pore complexes. However, as the thickness of bacterial membranes varies between different species and environmental conditions, this property could have an influence on the pore forming activity of nisin. To investigate this, the so-called hinge region of nisin (residues NMK was engineered to vary from one to six amino acid residues and specific activity against different indicators was compared. Antimicrobial activity in liquid culture assays showed that wild type nisin is most active, while truncation of the hinge region dramatically reduced the activity of the peptide. However, one or two amino acids extensions showed only slightly reduced activity against most indicator strains. Notably, some variants (+2, +1, -1, -2 exhibited higher antimicrobial activity than nisin in agar well diffusion assays against Lactococcus lactis MG1363, Listeria monocytogenes, Enterococcus faecalis VE14089, Bacillus sporothermodurans IC4 and Bacillus cereus 4153 at certain temperatures.

  20. Influence of regional cerebral blood volume on voxel-based morphometry.

    Science.gov (United States)

    Zheng, Lei; Cleppien, Dirk; Gass, Natalia; Falfan-Melgoza, Claudia; Vollmayr, Barbara; Hesser, Jürgen; Weber-Fahr, Wolfgang; Sartorius, Alexander

    2016-06-01

    The investigation of structural brain alterations is one focus in research of brain diseases like depression. Voxel-based morphometry (VBM) based on high-resolution 3D MRI images is a widely used non-invasive tool for such investigations. However, the result of VBM might be sensitive to local physiological parameters such as regional cerebral blood volume (rCBV) changes. In order to investigate whether rCBV changes may contribute to variation in VBM, we performed analyses in a study with the congenital learned helplessness (cLH) model for long-term findings. The 3D structural and rCBV data were acquired with T2 -weighted rapid acquisition with relaxation enhancement (RARE) pulse sequences. The group effects were determined by standard statistical parametric mapping (SPM) and biological parametric mapping (BPM) and examined further using atlas-based regions. In our genetic animal model of depression, we found co-occurrence of differences in gray matter volume and rCBV, while there was no evidence of significant interaction between both. However, the multimodal analysis showed similar gray matter differences compared with the standard VBM approach. Our data corroborate the idea that two group VBM differences might not be influenced by rCBV differences in genetically different strains. Copyright © 2016 John Wiley & Sons, Ltd. PMID:27074152

  1. Regional Influences on Chinese Medicine Education: Comparing Australia and Hong Kong.

    Science.gov (United States)

    Brosnan, Caragh; Chung, Vincent C H; Zhang, Anthony L; Adams, Jon

    2016-01-01

    High quality education programs are essential for preparing the next generation of Chinese medicine (CM) practitioners. Currently, training in CM occurs within differing health and education policy contexts. There has been little analysis of the factors influencing the form and status of CM education in different regions. Such a task is important for understanding how CM is evolving internationally and predicting future workforce characteristics. This paper compares the status of CM education in Australia and Hong Kong across a range of dimensions: historical and current positions in the national higher education system, regulatory context and relationship to the health system, and public and professional legitimacy. The analysis highlights the different ways in which CM education is developing in these settings, with Hong Kong providing somewhat greater access to clinical training opportunities for CM students. However, common trends and challenges shape CM education in both regions, including marginalisation from mainstream health professions, a small but established presence in universities, and an emphasis on biomedical research. Three factors stand out as significant for the evolution of CM education in Australia and Hong Kong and may have international implications: continuing biomedical dominance, increased competition between universities, and strengthened links with mainland China. PMID:27379170

  2. Simulation model analysis of the most promising geological sequestration formation candidates in the Rocky Mountain region, USA, with focus on uncertainty assessment

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Si-Yong [Univ. of Utah, Salt Lake City, UT (United States); Zaluski, Wade [Schlumberger Carbon Services, Houston, TX (United States); Will, Robert [Schlumberger Carbon Services, Houston, TX (United States); Eisinger, Chris [Colorado Geological Survey, Golden, CO (United States); Matthews, Vince [Colorado Geological Survey, Golden, CO (United States); McPherson, Brian [Univ. of Utah, Salt Lake City, UT (United States)

    2013-12-31

    The purpose of this report is to report results of reservoir model simulation analyses for forecasting subsurface CO2 storage capacity estimation for the most promising formations in the Rocky Mountain region of the USA. A particular emphasis of this project was to assess uncertainty of the simulation-based forecasts. Results illustrate how local-scale data, including well information, number of wells, and location of wells, affect storage capacity estimates and what degree of well density (number of wells over a fixed area) may be required to estimate capacity within a specified degree of confidence. A major outcome of this work was development of a new workflow of simulation analysis, accommodating the addition of “random pseudo wells” to represent virtual characterization wells.

  3. The influence of inter-annually varying albedo on regional climate and drought

    KAUST Repository

    Meng, Xianhong

    2013-05-05

    Albedo plays an important role in land-atmosphere interactions and local climate. This study presents the impact on simulating regional climate, and the evolution of a drought, when using the default climatological albedo as is usually done in regional climate modelling, or using the actual observed albedo which is rarely done. Here, time-varying satellite derived albedo data is used to update the lower boundary condition of the Weather Research and Forecasting regional climate model in order to investigate the influence of observed albedo on regional climate simulations and also potential changes to land-atmosphere feedback over south-east Australia. During the study period from 2000 to 2008, observations show that albedo increased with an increasingly negative precipitation anomaly, though it lagged precipitation by several months. Compared to in-situ observations, using satellite observed albedo instead of the default climatological albedo provided an improvement in the simulated seasonal mean air temperature. In terms of precipitation, both simulations reproduced the drought that occurred from 2002 through 2006. Using the observed albedo produced a drier simulation overall. During the onset of the 2002 drought, albedo changes enhanced the precipitation reduction by 20 % on average, over locations where it was active. The area experiencing drought increased 6.3 % due to the albedo changes. Two mechanisms for albedo changes to impact land-atmosphere drought feedback are investigated. One accounts for the increased albedo, leading to reduced turbulent heat flux and an associated decrease of moist static energy density in the planetary boundary layer; the other considers that enhanced local radiative heating, due to the drought, favours a deeper planetary boundary layer, subsequently decreasing the moist static energy density through entrainment of the free atmosphere. Analysis shows that drought related large-scale changes in the regional climate favour a

  4. Understanding Space Weather influence on earthquake triggering to shield people living in seismic regions

    Science.gov (United States)

    Khachikyan, Galina; Inchin, Alexander; Kim, Alexander; Khassanov, Eldar

    2016-07-01

    There is an idea at present that space weather can influence not only the technological infrastructure and people's health, but seismic activity as well. Space weather impact on the Earth results from magnetic reconnection between the Sun's and Earth's magnetic fields. The effectiveness of reconnection depends on sign and magnitude of Z-components in solar wind magnetic field and earth's magnetic field as measured in the geocentric solar magnetosphere (GSM) coordinate system. The more negative value of Zgsm in the solar wind magnetic field, and the more positive value of Zgsm in the geomagnetic field, the more solar wind energy penetrates into the earth's environment due to reconnection. It was found recently by Khachikyan et al. [2012, http://www.scirp.org/journal/ijg] that maximal possible earthquake magnitude in a particular seismic region (seismic potential - Mmax) may be determined, in first approximation, on the base of maximal geomagnetic Zgsm value in this region, namely: Mmax = (5.22 +- 0.17) + (0.78 +- 0.06) x [abs (Zgsm)]. In this report we present statistical results on association between variations in space weather and global seismic activity, and demonstrate that a great Sumatra earthquake (M=9.1, on December 26, 2004, at 00:58:53 GMT) indeed occurred in region where the geomagnetic Zgsm components are largest at the globe. In the time of earthquake occurrence, geomagnetic Zgsm value in the epicenter (3.30N, 95.980E) was equal to ~37147 nT. A range of possible maximal magnitude, as estimated from above relation, could be of 8.8 - 9.2. The recorded magnitude M=9.1 is within this range.

  5. Factors Influencing the Rating of Regional Economic Performance or Reasons why Prague has Become the 6th Best Economically Performing Region of the EU

    Directory of Open Access Journals (Sweden)

    Miloslav Chlad

    2011-06-01

    Full Text Available Regional Gross Domestic Product per capita is a key indicator for the distribution of financial resources within the Structural Funds in the EU. With regard to this fact, an increasing attention is also paid to this indicator in the Czech Republic (especially after its accession to the EU. Regional GDP per capita is often incorrectlypresented as the indicator of economic well-being of the population residing in the region. Some factors with significant impact on the value of regional GDP per capita and/or the ranking of regions in this international comparison are neglected. These factors include, for example, commuting to work, NUTS classification and/ or units of measure (PPS versus euro etc. The analysis shows the influence of these factors.

  6. The influence of the border position of the Pskov region on the socio-cultural values of the population

    Directory of Open Access Journals (Sweden)

    Manakov A.

    2010-01-01

    Full Text Available This article presents the results of a sociological research on national and supranational (civilizational identity of the Pskov region population conducted in 1999—2010. The Pskov region is the only European region of Russia that shares borders with three states, two of which are members of the EU. The author defines the areas of the neighbouring countries' sociocultural influence on the lives of the border territory population. The article also describes the existing stereotypes about Russia and the neighbouring countries as well as the influence of frequent trips to these countries on the attitude towards them. The assessment of the EU-Russia cooperation prospects by the Pskov region population is presented in comparison to the results of a similar research conducted in the Kaliningrad region.

  7. The IgH 3' regulatory region influences lymphomagenesis in Igλ-Myc mice.

    Science.gov (United States)

    Saad, Faten; Saintamand, Alexis; Cogné, Michel; Denizot, Yves

    2015-08-21

    The IgH 3'regulatory region (3'RR), encompassing the four transcriptional enhancers hs3a-hs1,2-hs3b-hs4, has a key role on class switch recombination, somatic hypermutation, IgH transcription and B-cell fate. In plasma cells, transcribed IgH and IgL loci often colocalized in transcription factories and an IgL transcription defect might translate into lowered IgH transcription. We explored whether the 3'RR would affect lymphomagenesis in Igλ-Myc transgenic mice prone to lymphoproliferations. Breeding Igλ-Myc transgenics in a background deficient for the 3'RR influences lymphomagenesis toward less mature lymphomas (16% vs 54%, p = 0.01, Z test for two population proportions). In a 3'RR-deficient background mature tumors less often expressed the CD43 antigen (54% vs 0%, p = 0.02), a membrane glycoprotein expressed on activated mature B-cells. In contrast, in a 3'RR-deficient background tumors more often expressed the CD5 antigen (32% vs 12%, p = 0.05) that may serve to control autoimmunity and that is suspected to play a role in leukemic transformation. Lymphoma myc transcript levels, the Ki67 index of proliferation, the clonality, the usage of V(D)J segments, and their somatic hypermutation status were not affected in the 3'RR-deficient background. In conclusion, most probably through its action during the maturation process, the 3'RR can influence lymphomagenesis even when not linked with an oncogene. PMID:25980500

  8. Fine-Scale Habitat Heterogeneity Influences Occupancy in Terrestrial Mammals in a Temperate Region of Australia.

    Science.gov (United States)

    Stirnemann, Ingrid; Mortelliti, Alessio; Gibbons, Philip; Lindenmayer, David B

    2015-01-01

    Vegetation heterogeneity is an inherent feature of most ecosystems, characterises the structure of habitat, and is considered an important driver of species distribution patterns. However, quantifying fine-scale heterogeneity of vegetation cover can be time consuming, and therefore it is seldom measured. Here, we determine if heterogeneity is worthwhile measuring, in addition to the amount of cover, when examining species distribution patterns. Further, we investigated the effect of the surrounding landscape heterogeneity on species occupancy. We tested the effect of cover and heterogeneity of trees and shrubs, and the context of the surrounding landscape (number of habitats and distance to an ecotone) on site occupancy of three mammal species (the black wallaby [Wallabia bicolor], the long-nosed bandicoot [Perameles nasuta], and the bush rat [Rattus fuscipes]) within a naturally heterogeneous landscape in a temperate region of Australia. We found that fine-scale heterogeneity of vegetation attributes is an important driver of mammal occurrence of two of these species. Further, we found that, although all three species responded positively to vegetation heterogeneity, different mammals vary in their response to different types of vegetation heterogeneity measurement. For example, the black wallaby responded to the proximity of an ecotone, and the bush rat and the long-nosed bandicoot responded to fine-scale heterogeneity of small tree cover, whereas none of the mammals responded to broad scale heterogeneity (i.e., the number of habitat types). Our results highlight the influence of methodological decisions, such as how heterogeneity vegetation is measured, in quantifying species responses to habitat structures. The findings confirm the importance of choosing meaningful heterogeneity measures when modelling the factors influencing occupancy of the species of interest. PMID:26394327

  9. Fine-Scale Habitat Heterogeneity Influences Occupancy in Terrestrial Mammals in a Temperate Region of Australia.

    Directory of Open Access Journals (Sweden)

    Ingrid Stirnemann

    Full Text Available Vegetation heterogeneity is an inherent feature of most ecosystems, characterises the structure of habitat, and is considered an important driver of species distribution patterns. However, quantifying fine-scale heterogeneity of vegetation cover can be time consuming, and therefore it is seldom measured. Here, we determine if heterogeneity is worthwhile measuring, in addition to the amount of cover, when examining species distribution patterns. Further, we investigated the effect of the surrounding landscape heterogeneity on species occupancy. We tested the effect of cover and heterogeneity of trees and shrubs, and the context of the surrounding landscape (number of habitats and distance to an ecotone on site occupancy of three mammal species (the black wallaby [Wallabia bicolor], the long-nosed bandicoot [Perameles nasuta], and the bush rat [Rattus fuscipes] within a naturally heterogeneous landscape in a temperate region of Australia. We found that fine-scale heterogeneity of vegetation attributes is an important driver of mammal occurrence of two of these species. Further, we found that, although all three species responded positively to vegetation heterogeneity, different mammals vary in their response to different types of vegetation heterogeneity measurement. For example, the black wallaby responded to the proximity of an ecotone, and the bush rat and the long-nosed bandicoot responded to fine-scale heterogeneity of small tree cover, whereas none of the mammals responded to broad scale heterogeneity (i.e., the number of habitat types. Our results highlight the influence of methodological decisions, such as how heterogeneity vegetation is measured, in quantifying species responses to habitat structures. The findings confirm the importance of choosing meaningful heterogeneity measures when modelling the factors influencing occupancy of the species of interest.

  10. Factors influencing the occurrence of floods in a humid region of diverse terrain

    Science.gov (United States)

    Benson, M.A.

    1963-01-01

    This report describes relations between flood peaks and hydrologic factors in a humid region with limited climatic variation but a diversity of terrain. Statistical multiple-regression techniques have been applied to hydrologic data on New England. Many topographic and climatic factors have been evaluated. and their relations to flood peaks have been examined. Many of the factors that influence flood peaks are interrelated, and part of the investigation consisted of determining the most efficient factor in each of several groups of highly interrelated variables. Drainage area size was found to be the most important factor. Main-channel slope was found to be next in importance, and a simple yet efficient indicator of main-channel slope was developed. The surface area of lakes and ponds was found to be a factor significantly influencing peak discharges. Of several indices tested the intensity of rainfall for a given duration and frequency was found to be most highly related to the magnitude of peaks. The increase in peaks caused by snowmelt and frozen ground was found to be related to an index of winter temperature-the average number of degrees below freezing in January. After the above-mentioned topographic and climatic characteristics had been taken into account, there remained deviations in peak discharges that showed an evident relation to orographic patterns. An orographic factor was mapped as defined by the peak discharges of record. Multiple-regression equations were developed that related, with acceptable accuracy, peak discharges of 1.2-to 300-year recurrence intervals to 6 hydrologic variables; 3 of the variables were topographic, 2 climatic, and 1 orographic. The remaining unexplained variations in flood-peak occurrence are believed attributable to the chance variation in storms.

  11. Influence of ecohydrologic feedbacks from simulated crop growth on integrated regional hydrologic simulations under climate scenarios

    Science.gov (United States)

    van Walsum, P. E. V.; Supit, I.

    2012-06-01

    Hydrologic climate change modelling is hampered by climate-dependent model parameterizations. To reduce this dependency, we extended the regional hydrologic modelling framework SIMGRO to host a two-way coupling between the soil moisture model MetaSWAP and the crop growth simulation model WOFOST, accounting for ecohydrologic feedbacks in terms of radiation fraction that reaches the soil, crop coefficient, interception fraction of rainfall, interception storage capacity, and root zone depth. Except for the last, these feedbacks are dependent on the leaf area index (LAI). The influence of regional groundwater on crop growth is included via a coupling to MODFLOW. Two versions of the MetaSWAP-WOFOST coupling were set up: one with exogenous vegetation parameters, the "static" model, and one with endogenous crop growth simulation, the "dynamic" model. Parameterization of the static and dynamic models ensured that for the current climate the simulated long-term averages of actual evapotranspiration are the same for both models. Simulations were made for two climate scenarios and two crops: grass and potato. In the dynamic model, higher temperatures in a warm year under the current climate resulted in accelerated crop development, and in the case of potato a shorter growing season, thus partly avoiding the late summer heat. The static model has a higher potential transpiration; depending on the available soil moisture, this translates to a higher actual transpiration. This difference between static and dynamic models is enlarged by climate change in combination with higher CO2 concentrations. Including the dynamic crop simulation gives for potato (and other annual arable land crops) systematically higher effects on the predicted recharge change due to climate change. Crop yields from soils with poor water retention capacities strongly depend on capillary rise if moisture supply from other sources is limited. Thus, including a crop simulation model in an integrated

  12. Influence of ecohydrologic feedbacks from simulated crop growth on integrated regional hydrologic simulations under climate scenarios

    Directory of Open Access Journals (Sweden)

    P. E. V. van Walsum

    2012-06-01

    Full Text Available Hydrologic climate change modelling is hampered by climate-dependent model parameterizations. To reduce this dependency, we extended the regional hydrologic modelling framework SIMGRO to host a two-way coupling between the soil moisture model MetaSWAP and the crop growth simulation model WOFOST, accounting for ecohydrologic feedbacks in terms of radiation fraction that reaches the soil, crop coefficient, interception fraction of rainfall, interception storage capacity, and root zone depth. Except for the last, these feedbacks are dependent on the leaf area index (LAI. The influence of regional groundwater on crop growth is included via a coupling to MODFLOW. Two versions of the MetaSWAP-WOFOST coupling were set up: one with exogenous vegetation parameters, the "static" model, and one with endogenous crop growth simulation, the "dynamic" model. Parameterization of the static and dynamic models ensured that for the current climate the simulated long-term averages of actual evapotranspiration are the same for both models. Simulations were made for two climate scenarios and two crops: grass and potato. In the dynamic model, higher temperatures in a warm year under the current climate resulted in accelerated crop development, and in the case of potato a shorter growing season, thus partly avoiding the late summer heat. The static model has a higher potential transpiration; depending on the available soil moisture, this translates to a higher actual transpiration. This difference between static and dynamic models is enlarged by climate change in combination with higher CO2 concentrations. Including the dynamic crop simulation gives for potato (and other annual arable land crops systematically higher effects on the predicted recharge change due to climate change. Crop yields from soils with poor water retention capacities strongly depend on capillary rise if moisture supply from other sources is limited. Thus, including a crop simulation

  13. The farmers' perceptions of ANPS pollution and its influencing factors in Poyang Lake Region, China.

    Science.gov (United States)

    Chen, Meiqiu; Chen, Mengjiao; Lu, Yanfei; Wang, Liguo; Huang, Yujiao

    2016-01-01

    Individual farmers represent the main management entities of agricultural production under the family-contract responsibility system in China, and thus play crucial roles in the prevention and control of agricultural nonpoint source (ANPS) pollution. The analysis of the farmers' perceptions of ANPS pollution as well as the factors affecting their perceptions can provide valuable information for relevant policy-making to preserve high quality water in Poyang Lake and regional quality of arable land. Through a survey titled 'Farmers' perceptions of ANPS pollution and farming behaviors in the Poyang Lake Region', the data related to the perceptions of farmers on ANPS pollution were collected. The factors that affect their awareness of ANPS pollution were identified with the method of boosted regression trees (BRT). The results indicated that the farmers had awareness of the risk of ANPS pollution to some extent, but they lacked adequate scientific knowledge. Generally, they had no consciousness about how to prevent and control ANPS pollution and did not understand techniques needed for proper scientifically sound application of fertilizers and pesticides. The main factors that influenced their perceptions of ANPS pollution are (from high to low): the ratio of total income which comes from farming, per capita farmland, age, education level, and household income. Some measures targeted to improve the prevention and control of ANPS pollution were proposed: developing modern agricultural techniques and promoting large-scale farming, increasing public campaigns related to ANPS pollution prevention and control with the goal of raising the level of awareness of farmers, and reforming the methods used to promote science and technology in agriculture and encourage the proper use of chemical fertilizers and pesticides. PMID:27054730

  14. The influence of regional surface soil moisture anomalies on forest fires in Siberia observed from satellites

    Energy Technology Data Exchange (ETDEWEB)

    Bartsch, A [Institute of Photogrammetry and Remote Sensing, Vienna University of Technology, 1040 Vienna (Austria); Balzter, H [Department of Geography, University of Leicester, University Road, Leicester LE1 7RH (United Kingdom); George, C, E-mail: ab@ipf.tuwien.ac.a [Earth Observation, Centre for Ecology and Hydrology, Crowmarsh Gifford, Wallingford OX10 8BB (United Kingdom)

    2009-10-15

    Forest fires are frequent in the Siberian taiga and are predicted to increase in frequency as a result of increased fire risk under drought conditions, and prolonged fire seasons caused by climate change. There is, however, some uncertainty as to the extent to which drought influences forest fire frequency at a regional scale. Here, we present an analysis of satellite derived soil moisture anomaly data from ERS-1/2 (ERS: Earth Resources Satellite) scatterometer data and burned area maps from MODIS/AVHRR/ATSR (Moderate Resolution Imaging Spectroradiometer/Advanced Very High Resolution Radiometer/Along-Track Scanning Radiometer) over Central Siberia for the years 1992-2000. The purpose of this study is to investigate the relationship of remotely sensed soil moisture deviations from the long-term mean and fire within the boreal biome on a sub-continental scale. Results show that wet surface soil moisture conditions limit the extent of burned area. They can prevent the outbreak of fires but the magnitude of a negative (dry) deviation does not determine the maximum size of fire affected areas. It is known from the literature, however, that an ignition is more likely to occur under low surface wetness conditions, such as those that we observed during July and August in both permafrost and non-permafrost regions. Although the burned area under drier conditions in July is lowest over non-permafrost, the actual number of fires is as high as over continuous permafrost. Approximately 80% of all events occurred under such conditions during that month. The fire size was below 50 km{sup 2} under moist conditions. Larger burned areas have in general not been detected when the surface wetness deviation exceeded +5%.

  15. The influence of regional surface soil moisture anomalies on forest fires in Siberia observed from satellites

    International Nuclear Information System (INIS)

    Forest fires are frequent in the Siberian taiga and are predicted to increase in frequency as a result of increased fire risk under drought conditions, and prolonged fire seasons caused by climate change. There is, however, some uncertainty as to the extent to which drought influences forest fire frequency at a regional scale. Here, we present an analysis of satellite derived soil moisture anomaly data from ERS-1/2 (ERS: Earth Resources Satellite) scatterometer data and burned area maps from MODIS/AVHRR/ATSR (Moderate Resolution Imaging Spectroradiometer/Advanced Very High Resolution Radiometer/Along-Track Scanning Radiometer) over Central Siberia for the years 1992-2000. The purpose of this study is to investigate the relationship of remotely sensed soil moisture deviations from the long-term mean and fire within the boreal biome on a sub-continental scale. Results show that wet surface soil moisture conditions limit the extent of burned area. They can prevent the outbreak of fires but the magnitude of a negative (dry) deviation does not determine the maximum size of fire affected areas. It is known from the literature, however, that an ignition is more likely to occur under low surface wetness conditions, such as those that we observed during July and August in both permafrost and non-permafrost regions. Although the burned area under drier conditions in July is lowest over non-permafrost, the actual number of fires is as high as over continuous permafrost. Approximately 80% of all events occurred under such conditions during that month. The fire size was below 50 km2 under moist conditions. Larger burned areas have in general not been detected when the surface wetness deviation exceeded +5%.

  16. Influence of building orientation on internal temperature in saharan climates, building located in Ghardaïa region (Algeria)

    OpenAIRE

    Bekkouche Sidi Mohammed El Amine; Benouaz Tayeb; Cherier Mohamed Kamel; Hamdani Maamar; Yaiche Mohamed Rédha; Khanniche Rachid

    2013-01-01

    In desert regions, the orientation of buildings has an important influence in the inside air temperature. In the present work, we carry out a study on the influence of the buildings orientation as well as the thermal insulation on the internal temperature. To do so, we have considered the case where only the exposed walls are isolated. The main objective of the current work is to determine the temperatures of the building in question with and without thermal insulation. This study aims ...

  17. Evaluating the influences of biomass burning during 2006 BASE-ASIA: a regional chemical transport modeling

    Directory of Open Access Journals (Sweden)

    J. S. Fu

    2011-12-01

    Full Text Available To evaluate the impact of biomass burning from Southeast Asia to East Asia, this study conducted numerical simulations during NASA's 2006 Biomass-burning Aerosols in South-East Asia: Smoke Impact Assessment (BASE-ASIA. Two typical episode periods (27–28 March and 13–14 April were examined. Two emission inventories, FLAMBE and GFED, were used in the simulations. The influences during two episodes in the source region (Southeast Asia contributed to the surface CO, O3 and PM2.5 concentrations as high as 400 ppbv, 20 ppbv and 80 μg m−3, respectively. The perturbations with and without biomass burning of the above three species during the intense episodes were in the range of 10 to 60%, 10 to 20% and 30 to 70%, respectively. The impact due to long-range transport could spread over the southeastern parts of East Asia and could reach about 160 to 360 ppbv, 8 to 18 ppbv and 8 to 64 μg m−3 on CO, O3 and PM2.5, respectively; the percentage impact could reach 20 to 50% on CO, 10 to 30% on O3, and as high as 70% on PM2.5. In March, the impact of biomass burning was mainly concentrated in Southeast Asia and Southern China, while in April the impact becomes slightly broader, potentially including the Yangtze River Delta region.

    Two cross-sections at 15° N and 20° N were used to compare the vertical flux of biomass burning. In the source region (Southeast Asia, CO, O3 and PM2.5 concentrations had a strong upward transport from surface to high altitudes. The eastward transport becomes strong from 2 to 8 km in the free troposphere. The subsidence process during the long-range transport contributed 60 to 70%, 20 to 50%, and 80% to CO, O3 and PM2.5, respectively to surface in the downwind area. The study reveals the significant impact of Southeastern Asia biomass burning on the air quality in both local and

  18. Groundwater Modeling in Coastal Arid Regions Under the Influence of Marine Saltwater Intrusion

    Science.gov (United States)

    Walther, Marc; Kolditz, Olaf; Grundmann, Jens; Liedl, Rudolf

    2010-05-01

    The optimization of an aquifer's "safe yield", especially within agriculturally used regions, is one of the fundamental tasks for nowaday's groundwater management. Due to the limited water ressources in arid regions, conflict of interests arise that need to be evaluated using scenario analysis and multicriterial optimization approaches. In the context of the government-financed research project "International Water Research Alliance Saxony" (IWAS), the groundwater quality for near-coastal, agriculturally used areas is investigated under the influence of marine saltwater intrusion. Within the near-coastal areas of the study region, i.e. the Batinah plains of Northern Oman, an increasing agricultural development could be observed during the recent decades. Simultaneously, a constant lowering of the groundwater table was registered, which is primarily due to the uncontrolled and unsupervised mining of the aquifers for the local agricultural irrigation. Intensively decreased groundwater levels, however, cause an inversion of the hydraulic gradient which is naturally aligned towards the coast. This, in turn,leads to an intrusion of marine saltwater flowing inland, endangering the productivity of farms near the coast. Utilizing the modeling software package OpenGeoSys, which has been developed and constantly enhanced by the Department of Environmental Informatics at the Helmholtz Centre for Environmental Research Leipzig (UFZ; Kolditz et al., 2008), a three-dimensional, density-dependent model including groundwater flow and mass transport is currently being built up. The model, comprehending three selected coastal wadis of interest, shall be used to investigate different management scenarios. The main focus of the groundwater modelling are the optimization of well positions and pumping schemes as well as the coupling with a surface runoff model, which is also used for the determination of the groundwater recharge due to wadi runoff downstream of retention dams. Based on

  19. Influence of configuration interaction on satellite lines of xenon and tin in the EUV region

    International Nuclear Information System (INIS)

    Theoretical line strengths and positions of satellite lines of xenon and tin ions are computed in the EUV region (transitions from doubly excited configurations or between singly excited configurations). Calculations are conducted with HULLAC parametric multi-configuration relativistic code. Influence of configuration interaction is investigated for doubly excited configurations of ions from Pd- to Rb-like. The emission close to 13.5 nm, which is of interest to the EUV lithography, is detailed. A strong narrowing of 4d-4f/4d-4p group of satellite lines is observed, compared to the calculation without configuration interaction. The emissivity is strongly enhanced in the centre of this group of lines. This strongly increases the EUV emission at 13.5 nm for tin at moderate to high densities. The EUV emission of xenon at 13.5 nm is enhanced by 4d-5p satellite lines of Xe 9+ and 10+. Radiative transitions between singly excited configurations and between doubly excited configurations also enhance the emission at 13.5 nm, especially 6g-4f transitions of Xe 9+, 10+ and 5g-4f transitions of Xe 11+

  20. Influence of different parent materials on litter decomposition in the east mediterranean region

    International Nuclear Information System (INIS)

    Litter decomposition is the fundamental pathway for the turn of carbon, nitrogen and nutrients to terrestrial ecosystem and strongly influenced by climatic variables, litter quality and microbial activity. This study was carried out to investigate the effects of two different parent materials (conglomerate and marl) on litter decomposition and the relationships between litter quality and decomposition rate of Pinus pinea L. and Ceratonia siliqua L. in the East Mediterranean Region of Turkey. Fresh fallen litters from P. pinea and C. siliqua plants were determined contents of C, N, P, lignin and cellulose. The litter bag method was used to determine their mass loss in the sampling area for 544 days. Litter mass loss in decomposition varied in the following order: Ceratoniamarl>Ceratoniacong>Pinuscong>Pinusmarl. There were no significant differences among the samples in terms of lignin contents of initial litter while cellulose content was only statistically significant between Pinuscong and Ceratoniacong (p<0.05). These results suggested that litter decomposition is affected from different parent materials (conglomerate and marl) and plant diversity. (author)

  1. Regional Visibility Statistics in the United States: Natural and Transboundary Pollution Influences, and Implications for the Regional Haze Rule

    OpenAIRE

    Park, Rojkin J.; Jacob, Daniel J.; Kumar, Naresh; Yantosca, Robert M.

    2006-01-01

    The Regional Haze Rule of the US Environmental Protection Agency mandates reduction in US anthropogenic emissions to achieve linear improvement of visibility in wilderness areas over the 2004–18 period toward an endpoint of natural visibility conditions by 2064. Linear improvement is to apply to the mean visibility degradation on the statistically 20% worst days, measured as a Haze Index in units of deciviews (log of aerosol extinction). We use a global chemical transport model (GEOS-Chem) wi...

  2. Physical Mapping of the Holoprosencephaly Critical Region in 21q22.3, Exclusion of SIM2 as a Candidate Gene for Holoprosencephaly, and Mapping of SIM2 to a Region of Chromosome 21 Important for Down Syndrome

    OpenAIRE

    Muenke, Maximilian; Bone, Linda J.; Mitchell, Heather F.; Hart, Iris; Walton, Katy; Hall-Johnson, Karen; Ippel, Elly F; Dietz-Band, Jeanne; Kvaløy, Kirsti; Fan, Chen-Ming; Tessier-Lavigne, Marc; Patterson, David

    1995-01-01

    We set out to define the holoprosencephaly (HPE) critical region on chromosome 21 and also to determine whether there were human homologues of the Drosophila single-minded (sim) gene that might be involved in HPE. Analysis of somatic cell hybrid clones that contained rearranged chromosomes 21 from HPE patients defined the HPE minimal critical region in 21q22.3 as D21S113 to qter. We used established somatic cell hybrid mapping panels to map SIM2 to chromosome 21 within subbands q22.2-q22.3. A...

  3. Time-Series Analysis of Remotely-Sensed SeaWiFS Chlorophyll in River-Influenced Coastal Regions

    Science.gov (United States)

    Acker, James G.; McMahon, Erin; Shen, Suhung; Hearty, Thomas; Casey, Nancy

    2009-01-01

    The availability of a nearly-continuous record of remotely-sensed chlorophyll a data (chl a) from the Sea-viewing Wide Field-of-view Sensor (SeaWiFS) mission, now longer than ten years, enables examination of time-series trends for multiple global locations. Innovative data analysis technology available on the World Wide Web facilitates such analyses. In coastal regions influenced by river outflows, chl a is not always indicative of actual trends in phytoplankton chlorophyll due to the interference of colored dissolved organic matter and suspended sediments; significant chl a timeseries trends for coastal regions influenced by river outflows may nonetheless be indicative of important alterations of the hydrologic and coastal environment. Chl a time-series analysis of nine marine regions influenced by river outflows demonstrates the simplicity and usefulness of this technique. The analyses indicate that coastal time-series are significantly influenced by unusual flood events. Major river systems in regions with relatively low human impact did not exhibit significant trends. Most river systems with demonstrated human impact exhibited significant negative trends, with the noteworthy exception of the Pearl River in China, which has a positive trend.

  4. Postpartum practices of puerperal women and their influencing factors in three regions of Hubei, China

    Directory of Open Access Journals (Sweden)

    Chen Banghua

    2006-11-01

    Full Text Available Abstract Background 'Sitting month' is a Chinese tradition for women's postpartum custom. The present study aims to explore the postpartum dietary and health practices of puerperal women and identify their influential factors in three selected regions of Hubei, China. Methods A cross-sectional retrospective study was conducted in the selected urban, suburban and rural areas in the province of Hubei from 1 March to 30 May 2003. A total of 2100 women who had given birth to full-term singleton infants in the past two years were selected as the participants. Data regarding postpartum practices and potentially related factors were collected through questionnaire by trained investigators. Results During the puerperium, 18% of the participants never ate vegetables, 78.8% never ate fruit and 75.7% never drank milk. Behaviour taboos such as no bathing, no hair washing or teeth brushing were still popular among the participants. About half of the women didn't get out of the bed two days after giving birth. The average time they stayed in bed during this period was 18.0 h. One third of them didn't have any outdoor activities in that time periods. The educational background of both women and their spouses, location of their residence, family income, postnatal visit, nutrition and health care educational courses were found to be the influencing factors of women's postpartum practices. Conclusion Traditional postpartum dietary and health behaviours were still popular among women in Hubei. Identifying the factors associated with traditional postpartum practices is critical to develop better targeting health education programs. Updated Information regarding postpartum dietary and health practices should be disseminated to women.

  5. The influence of carbon exchange of a large lake on regional tracer-transport inversions: results from Lake Superior

    International Nuclear Information System (INIS)

    Large lakes may constitute a significant component of regional surface-atmosphere fluxes, but few efforts have been made to quantify these fluxes. Tracer-transport inverse models that infer the CO2 flux from the atmospheric concentration typically assume that the influence from large lakes is negligible. CO2 observations from a tall tower in Wisconsin segregated by wind direction suggested a CO2 signature from Lake Superior. To further investigate this difference, source-receptor influence functions derived using a mesoscale transport model were applied and results revealed that air masses sampled by the tower have a transit time over the lake, primarily in winter when the total lake influence on the tower can exceed 20% of the total influence of the regional domain. When the influence functions were convolved with air-lake fluxes estimated from a physical-biogeochemical lake model, the overall total contribution of lake fluxes to the tall tower CO2 were mostly negligible, but potentially detectable in certain periods of fall and winter when lake carbon exchange can be strong and land carbon efflux weak. These findings suggest that large oligotrophic lakes would not significantly influence inverse models that incorporate tall tower CO2.

  6. Public Administration, Regional Policy, and the Committee of the Regions - Interaction of Regional, National and European Influences in the Pre-accession Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Kostelecký, Tomáš

    2005-01-01

    Roč. 6, č. 1 (2005), s. 14-34. ISSN 1335-5945 Institutional research plan: CEZ:AV0Z70280505 Keywords : multilevel government * public administration * Committee of the Regions Subject RIV: AO - Sociology, Demography

  7. Dynamic Changes, Regional Differences, and Influencing Factors of CO2 Emission Performance in China%Dynamic Changes, Regional Differences, and Influencing Factors of CO2 Emission Performance in China

    Institute of Scientific and Technical Information of China (English)

    Wang Qunwei; Zhou Peng; Zhou Dequn

    2011-01-01

    This paper proposes to use DEA models with undesirable outputs to construct the Malmquist index that can be use to investigate the dynamic changes of CO2 emission performance. With the index, the authors have measured the CO2 emission performance of 28 provinces and autonomous regions in China from 1996 to 2007; with the convergence theory and panel data regression model, the authors analyze the regional differences and the influencing factors. It is found that the performance of CO2 emissions in China has been continuously improved mainly due to the technological progress, and the average improvement rate is 3.25%, with a cumulative improvement rate of 40.86%. In addition, the CO2 emission performance varies across four regions. As a whole, the performance score of eastern China is the highest. The northeastern and central China has relatively lower performance scores, and the western China is relatively backward. The regional differences are decreasing, and the performance of CO2 emissions is convergent. The influence of some factors on the performance of CO2 emissions is significant, such as the level of economic development, the level of industrial structure, energy intensity, and ownership structure. The influence of some factors, such as opening-up to the outside world, on the performance of CO2 emissions is not significant.

  8. The influence of external forcing on subdecadal variability of regional surface temperature in CMIP5 simulations of the last millennium

    Science.gov (United States)

    Le, Thanh; Sjolte, Jesper; Muscheler, Raimund

    2016-02-01

    We use Granger causality to investigate the influences of external forcings on subdecadal variability of regional near-surface air temperature (SAT) in past millennium simulations (period 850-1850 A.D.) of the Coupled Model Intercomparison Project Phase 5 (CMIP5) models. Our results strengthen the conclusion for robust influence of volcanic forcing on SAT during preindustrial times of the last millennium. The SAT response to solar variations is detected in tropical and subtropical regions. In other regions, this response is weak. The impact of greenhouse gases (GHGs) radiative forcing to regional SAT is weak and uncertain. This is most probably due to the low amplitude of the variations in GHGs and hence weak GHGs forcing during the preindustrial millennium. The low agreement between models in simulating the impacts of solar variations on SAT in several regions suggests the different dynamical responses in these models, possibly associated with inaccurate parameterization of the processes related to solar forcing. Our analysis suggests that internal climate variability played a more significant role than external forcings in short-term SAT variability in the regions of the North Atlantic, the North Pacific, the Arctic, the Antarctic Peninsula, and its surrounding oceans. The possibility of long-term impacts of external forcings on SAT and the uncertainties that might be contained due to effects of internal climate modes other than El Niño-Southern Oscillation underscore the necessity for a more detailed understanding of the dynamical response of SAT to external forcings.

  9. Downregulation of miR-320a/383-sponge-like long non-coding RNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation.

    Science.gov (United States)

    Lü, M; Tian, H; Cao, Y-X; He, X; Chen, L; Song, X; Ping, P; Huang, H; Sun, F

    2015-01-01

    Long non-coding RNAs (lncRNAs), which are extensively transcribed from the genome, have been proposed to be key regulators of diverse biological processes. However, little is known about the role of lncRNAs in regulating spermatogenesis in human males. Here, using microarray technology, we show altered expression of lncRNAs in the testes of infertile men with maturation arrest (MA) or hypospermatogenesis (Hypo), with 757 and 2370 differentially down-regulated and 475 and 163 up-regulated lncRNAs in MA and Hypo, respectively. These findings were confirmed by quantitative real-time PCR (qRT-PCR) assays on select lncRNAs, including HOTTIP, imsrna320, imsrna292 and NLC1-C (narcolepsy candidate-region 1 genes). Interestingly, NLC1-C, also known as long intergenic non-protein-coding RNA162 (LINC00162), was down-regulated in the cytoplasm and accumulated in the nucleus of spermatogonia and primary spermatocytes in the testes of infertile men with mixed patterns of MA compared with normal control. The accumulation of NLC1-C in the nucleus repressed miR-320a and miR-383 transcript and promoted testicular embryonal carcinoma cell proliferation by binding to Nucleolin. Here, we define a novel mechanism by which lncRNAs modulate miRNA expression at the transcriptional level by binding to RNA-binding proteins to regulate human spermatogenesis. PMID:26539909

  10. Modeling Circulation Patterns that Influence Connectivity of Remote Ecosystems in the Wider Caribbean Region and the Gulf of Mexico

    Science.gov (United States)

    Kourafalou, V. H.; Halliwell, G.; Hogan, P.; Kang, H.; Schiller, R.; Paris, C.

    2008-05-01

    The Wider Caribbean Region (WCR) comprises the insular and coastal States and Territories with coasts on the Caribbean Sea and Gulf of Mexico as well as waters of the Atlantic Ocean adjacent to these States and Territories and includes 28 island and continental countries. The main sub-basins are inter-connected with a large scale current system that includes the North Brazil Current, the Caribbean Current, the Loop Current and the Florida Current. This current system and associated rings and eddies provide the physical background for the connectivity of WCR ecosystems that can be at great distances from each other. A hierarchy of regional numerical models based on the HYbrid Coordinate Ocean Model (HYCOM) has been developed to study the physical transport mechanisms and support efforts under the Integrated Ocean Observing System (IOOS): CARIB-HYCOM (WCR region); GoM-HYCOM (Gulf of Mexico region), Northern Gulf of Mexico (NGoM region), WFS-HYCOM (West Florida Shelf region), SoFLA-HYCOM (South Florida region) and FKEYS- HYCOM (Florida Keys region). The models range in resolution from 900m to 4 km and they are gradually nested to Atlantic basin-wide and global HYCOM models of 7-8 km resolution. This multi-nested approach allows the detailed study of regional processes, while maintaining the interaction with surrounding regions. This is an important methodology in the Wider Caribbean Region, where the presence of complicated topography and the large scale current system dictate strong coastal to offshore interactions and inter-basin exchanges. The multi-nested modeling approach has allowed the study of circulation and transport processes in the Caribbean Sea and the Gulf of Mexico. Examples will concentrate on the transport of low salinity, nutrient rich waters originating at the Amazon and Mississippi Rivers and the connectivity pathways that influence larval transport. Boundary condition and data assimilation needs for pre-operational forecasting of such pathways

  11. The Important Candidate Genes in Goats - A Review

    Directory of Open Access Journals (Sweden)

    China SUPAKORN

    2009-01-01

    Full Text Available A total of 271 candidate genes have been detected in goats. However, comprehensive investigations have been carried out on the polymorphism of some genes, involved in the control of economic traits. Candidate genes have an effect on the physiological pathway, metabolism and expression of phenotypes. For growth traits, growth hormone (GH, growth hormone receptor (GHR, insulin like growth factor I (IGF-I, leptin (LEP, caprine pituitary specific transcription factor-1 (POU1F1, caprine myostatin (MSTN and bone morphogenetic protein (BMP genes are necessary for bone formation, birth weight, weaning weight, body condition and muscle growth. For reproduction, forkhead box L 2 (FOXL2, melatonin receptor 1A (MTNR1A, sex determination region of Y chromosome (SRY and amelogenin (AMEL genes influence sex determination and proliferation. The major candidate genes for milk yield and milk composition traits are the casein gene and their family. Keratin associated protein (KAP and melanocortin 1 receptor (MC1R genes are candidate genes for wool traits. The major histocompatibility complex (MHC gene is considered important for the immune system and disease resistance traits. The functions of these genes on economically important traits are different. Some genes have synergistic or antagonistic effects in nature for expression of phenotypic traits. On the other hand, some genes could control more than one trait. Also, the producers should be concerned with these effects because selection of a single trait by using only a gene could affect other traits. Therefore, the identification of candidate genes and their mutations which cause variations of gene expression and phenotype of economic traits will help breeders to search some genetic markers for these economic traits. It may be used as an aid in the selection of parent stock at an early age in the future.

  12. Regional Genetic Structure and Environmental Variables Influence our Conservation Approach for Feather Heads (Ptilotus macrocephalus).

    Science.gov (United States)

    Ahrens, Collin W; James, Elizabeth A

    2016-05-01

    Continued alterations to the Australian environment compromise the long-term viability of many plant species. We investigate the population genetics of Ptilotus macrocephalus, a perennial herb that occurs in 2 nationally endangered communities on the Victorian Volcanic Plain Bioregion (VVP), Australia, to answer key questions regarding regional differentiation and to guide conservation strategies. We evaluate genetic structure and diversity within and among 17 P. macrocephalus populations from 3 regions of southeastern Australia using 17 microsatellite markers developed de novo. Genetic structure was present in P. macrocephalus between the 3 regions but not at the population level. Environmental factors, namely temperature and precipitation, significantly explained differentiation between the North region and the other 2 regions indicating isolation by environment. Within regions, genetic structure currently shows a high level of gene flow and genetic variation. Our results suggest that within-region gene flow does not reflect current habitat fragmentation in southeastern Australia whereas temperature and precipitation are likely to be responsible for the differentiation detected among regions. Climate change may severely impact P. macrocephalus on the VVP and test its evolutionary resilience. We suggest taking a proactive conservation approach to improve long-term viability by sourcing material for restoration to assist gene flow to the VVP region to promote an increased adaptive capacity. PMID:26865733

  13. RESEARCH ON THE INFLUENCE OF REGIONAL POLICY DEVELOPMENT OF RURAL COMMUNITIES

    Directory of Open Access Journals (Sweden)

    Camelia MĂNESCU

    2015-04-01

    Full Text Available Regional development is a new concept whose opportunities are enhancing and diversifying economic activities, enhancing investments in the private sector, contributing to unemployment reduction, and last but not least improving the standard of living. To assure the development policies in economy, agriculture, forestry, tourism, regional planning, infrastructure, and education etc., it is needed to take into account the specific conditions of the rural regions, Romanian villages and to observe the principles of subsidiarity and solidarity. In this context, the paper aimed to point out the opportunities for the development of rural communities through regional development.

  14. Logit analysis of socio-economic factors influencing people to become fishermen in the central region of Ghana

    Directory of Open Access Journals (Sweden)

    Acquah Henry D.

    2011-01-01

    Full Text Available This study analyzes the socio-economic factors that influence people’s decision to become fishermen in the central region of Ghana. Using a well structured interview schedule, a random sample of 98 people from Elmina in the central region of Ghana was selected for the study. Results from the descriptive statistics analysis of respondents identified fishing as a family business, minimum skills requirement and ready market for fish demand as factors that motivated majority of the people into fishing. Lack of storage facilities, access to credit, lack of government assistance and unpredictable changes in weather conditions on sea were the main constraints to fishing activities. Results from the logistic regression model indicated that household size and access to credit were significant factors that positively influenced people’s decision to become fishermen. The regression analysis further revealed that engaging in other income generating activity and being educated significantly reduces the probability to start fishing business.

  15. The Influence of Nationalism in Mercosur and in South America - can the regional integration project survive?

    DEFF Research Database (Denmark)

    Christensen, Steen Fryba

    2007-01-01

    The article discusses if the tendency towards nationalism in Latin America seems to get in the way of the regional integration project in Mercosur and at the level of South America......The article discusses if the tendency towards nationalism in Latin America seems to get in the way of the regional integration project in Mercosur and at the level of South America...

  16. Toward a Quantitative Assessment of the Influence of Regional Emission Sources on Ozone Production in the Colorado Front Range

    Science.gov (United States)

    McDuffie, E. E.; Dube, W. P.; Wolfe, D. E.; Tevlin, A.; Gilman, J.; Lerner, B. M.; De Gouw, J. A.; Murphy, J. G.; Fischer, E. V.; Brown, S. S.; Angevine, W. M.; Edwards, P.; Williams, E. J.

    2015-12-01

    Photochemical ozone production results from the oxidation and reaction of volatile organic compounds (VOCs) with nitrogen oxides (NOx = NO2 + NO). As with many US urban regions, ozone levels observed in the Northern Front Range Metropolitan Region of Colorado are influenced by urban emissions of NOx and VOCs. Despite nationwide decreases in these urban emissions, the Front Range of Colorado is one of the few US locations where ozone is currently increasing. It has also recently gone out of compliance with national ambient air quality standards for ozone during summer months. High ozone in Colorado may result from a number of factors, including long-range transport from Asia, increased influence of biomass burning, population increases, or increased emissions from oil and gas activities. The Front Range is home to the Denver-Julesburg (D-J) Basin, which has recently been experiencing a rise in oil and natural gas (O&NG) activity associated with the increase in non-conventional drilling techniques. The VOC and NOx emissions from O&NG activity in close proximity to the urban area may uniquely influence ozone in this region. This presentation will focus on using reactive nitrogen (NOx, NOy) and ozone measurements from a tall (300 m) tower to study the influence of local emissions on Front Range ozone. The tower is located between the D-J Basin and agricultural areas to the north and the Denver metro area to the south. In-situ reactive nitrogen and ozone measurements were collected using a custom Cavity Ring-Down instrument. Additional CH4, CO, and NH3 measurements from the tower serve as tracers for O&NG, urban, and agricultural emissions. Concurrently measured aircraft data is used to confirm the relationships between the tracer species. This presentation will discuss methods for determining the contributions of different emission sources to Front Range ozone, with a focus on differentiating the influence of urban and O&NG sources.

  17. Spatial Distribution of Calibrated WOFOST Parameters and Their Influence on the Performances of a Regional Yield Forecasting System

    OpenAIRE

    2013-01-01

    We investigate in this study (i) a redefinition of crop variety zonations at a spatial scale of 10x10 km, and (ii) the influence of recalibrated crop parameters on regional yield forecasting of winter wheat and grain maize in western Europe. The baseline zonation and initial crop parameter set was derived from the operational European crop growth monitoring system (CGMS) which involves the agrometeorological model WOFOST. Air temperature data from 325 weather stations over the 1992-2007 peri...

  18. Influence of regional climates on the availability of decaying-log microsite for coniferestablishment on Vancouver Island, Canada

    OpenAIRE

    Nobuyuki, Katsumata; 勝又, 暢之; Susumu, OKITSU; 沖津, 進; Yoshinori, Minami; 南, 佳典

    2009-01-01

    We examined the influence of regional climatic conditions on the availability of a decaying-log microsite for theestablishment of western hemlock( Tsuga heterophylla), western redcedar( Thuja plicata), and Douglas-fir(Pseudotsuga menziesii). Field research was carried out at three sites located within different climatic zones onsouthern Vancouver Island, British Columbia, Canada. We investigated whether trees( > 4 m tall) are establishedon the decaying-logs or not. We also compared the densit...

  19. THE INFLUENCE OF DOUBLE IMMUNIZATION ON MORBIDITY OF MEASLES, MUMPS AND RUBELLA IN THE NORTH-WEST REGION OF RUSSIA

    Directory of Open Access Journals (Sweden)

    L. V. Lyalina

    2012-01-01

    Full Text Available Abstract. The influence of double immunization on measles, mumps and rubella incidence in the North-West Federal District (North-West Russia has been analyzed. Due to the vaccination of the population morbidity of these infections in the region has decreased significantly. The necessity to improve the surveillance system due to changes in the manifestations of the epidemic process particularly connected with increasing of proportion of adults among patients has been proposed.

  20. Study on the atmospheric boundary layer and its influence on regional air quality over the Pearl River delta

    OpenAIRE

    Wu, M.(Enrico Fermi Institute, University of Chicago, Chicago, IL, United States of America); Wu, D.; Fan, Q.; B. M. Wang; Li, H W; S. J. Fan

    2013-01-01

    To study the structure of atmospheric boundary layer (ABL) and its influence on regional air quality over the Pearl River delta (PRD), two ABL intensive observations were conducted at Panyu (urban station) and Xinken (non-urban station, near estuary) of PRD during October 2004 and July 2006, respectively. Based on the ABL intensive observation data analysis, the typical weather condition type associated with poor air quality over PRD could be summarized into two kinds: the warmed perio...

  1. The influence of regional basic science campuses on medical students' choice of specialty and practice location: a historical cohort study

    Directory of Open Access Journals (Sweden)

    Brokaw James J

    2009-06-01

    Full Text Available Abstract Background Indiana University School of Medicine (IUSM employs eight regional basic science campuses, where half of the students complete their first two years of medical school. The other half complete all four years at the main campus in Indianapolis. The authors tested the hypothesis that training at regional campuses influences IUSM students to pursue primary care careers near the regional campuses they attended. Methods Medical school records for 2,487 graduates (classes of 1988–1997 were matched to the 2003 American Medical Association Physician Masterfile to identify the medical specialty and practice location of each graduate. Multivariate logistic regression was performed to assess the effect of regional campus attendance on students' choice of medical specialty and practice location, while simultaneously adjusting for several covariates thought to affect these career outcomes. Results Compared to Indianapolis students, those who attended a regional campus were somewhat more likely to be white, have parents with middle class occupations, and score slightly lower on the Medical College Admission Test. Any such differences were adjusted for in the regression models, which predicted that four of the regional campuses were significantly more likely than Indianapolis to produce family practitioners, and that five of the regional campuses were significantly more likely than the others to have former students practicing in the region. When analyzed collectively, attendance at any regional campus was a significant predictor of a primary care practice located outside the Indianapolis metropolitan area. Conclusion Attending a regional campus for preclinical training appears to increase the likelihood of practicing primary care medicine in local communities.

  2. Influence of natural and technological emergency situations on tourism and sustainable development in St.Petersburg and Leningrad region (Russia)

    Science.gov (United States)

    Shnyparkov, A. L.; Petrova, E. G.; Vashchalova, T. V.; Gavrilova, S. A.; Danilina, A. V.; Gryaznova, V. V.

    2012-04-01

    St.Petersburg and Leningrad region belong to the most populated and tourist-active regions in the European part of Russia. St.Petersburg is a second important transportation connection point in Russia, there are many industrial and infrastructure facilities in Leningrad region such as chemical plants, mechanic engineering, power stations including a nuclear power station, etc. That is why a lot of technical objects and people can be influenced or damaged by natural hazards and various types of technological accidents can be triggered by natural phenomena that have place in the region. According to the Russian Ministry of Emergency Situation, Leningrad region has a medium level of frequency of emergency situations caused by natural triggers (two to four cases a year). The climatic and orographic conditions of the area contribute to the development of many different types of dangerous natural processes such as floods, storms, strong winds, extreme heat and frost, snowfalls, heavy rains, hale, etc. Hydro-meteorological phenomena are the most often among all natural triggers of emergency situations in the region; about 50% of them are caused by storms and strong winds and 25% by floods. The biggest number of natural emergency situations happens in St.Petersburg. Storms make the marine navigation more difficult and even block the port sometimes. In Leningrad region, 5-10 villages and cities (including St.Petersburg) are at risk to be flooded. In November 1999, the work of Leningradskaya nuclear power station was partly blocked due to the increasing in water level. The federal road Moscow-St.Petersburg is often under influence of heavy snowfalls that cause many problems for transport system of the region during the winter. The majority of technological emergency situations are caused by fires in industrial facilities and residential sector, trafic accidents and shipcrashes. Sometimes natural phenomena can also trigger technological accidents. However, their frequency is

  3. Evaluating the regional influence of Santiago de Chile on air quality and meteorology during VOCALS-REX

    Science.gov (United States)

    Mena, M.; Carmichael, G. R.; Molina, L. T.; Spak, S.; Campos, T.; Mc Naughton, C.; Clarke, A.; Gallardo, L.

    2009-04-01

    The VOCALS campaign was carried out in Chile during October-November 2008, gathering hundreds of scientists from all over the world with the objective to study stratocumulus decks in the East South Pacific, off the coast of Chile and Peru. Surface and airborne platforms measured multiple chemical and meteorological parameters, with support from chemical weather forecast models. Anthropogenic influence on meteorology and climate was evidenced due to in situ measurements, and satellite observations, as was expected from the large point sources of sulfur due to smelters and power plants in the region. However certain conditions benefited long range transport from central Chile, which made the Santiago plume clearly discernible (high ozone, organic aerosol, low CO) as sampled by the NSF C-130 almost 2000 km north of the city. This research will highlight how model products can provide guidance on the sources of the air masses sampled during the campaign, and how the Santiago plume influences regional air quality and meteorology (focusing on effective cloud radii and brightness temperature differences satellite measurements). Ultimately the research shows that the campaign's objective of contrasting cloud properties between pristine and anthropogenically influenced airmasses provided a unique opportunity to isolate the signal of a large emerging South American megacity from remote regions of the East South Pacific.

  4. Influence of the temperature of positive ions on the sheath formation and parameter space region in magnetized electronegative plasmas

    International Nuclear Information System (INIS)

    The parameter space regions and the sheath formation in an electronegative discharge in the presence of thermal positive ions and oblique magnetic field are investigated. It is assumed that the negative species are in thermal equilibrium and the positive ions have a finite temperature. Three regimes of uniform, multilayer stratified and pure stratified are found as functions of positive and negative ion temperature, electronegativity and the magnetic field. The influence of positive ion temperature in the presence of magnetic field on the profiles of the positive ion density, positive ion velocity and electric potential are investigated. The positive ion flux at the sheath edge as a function of magnetic field is obtained for different collisionality and positive and negative ion temperatures. Finally, the influence of the magnetic field, collision frequency and the positive ion temperature on the parameter space regions are discussed. - Highlights: • Obtaining positive ion flux at sheath edge as a function of magnetic field. • The magnetic field effects to the oscillations appears for higher values of γ. • Obtaining the parameter space region in magnetized electronegative for thermal ions. • By increasing the positive ion temperature, the presheath thickness increases. • In the presence of the hot positive ions, influence of the magnetic field vanishes

  5. Far-field model of the regional influence of affluent plumes from Ocean Thermal Energy Conversion (OTEC) plants

    Science.gov (United States)

    Wang, D. P.

    1985-07-01

    Ocean thermal energy conversion (OTEC) plants discharge large volumes of cold water into the upper ocean. A three-dimensional, limited-area model was developed to investigate the regional influence of the far-field effluent plume created by the negatively buoyant discharge. The model was applied to discharges from a 40-MW sub e OTEC plant into coastal waters characterized by various ambient ocean conditions. A typical ambient temperature structure and nutrient distribution, as well as the behavior of the effluent plume itself, were strongly modified by the discharge-induced circulation. Although temperature perturbations in the plume were small, upward entrainment of nutrients from below the thermocline was significant. The regional influence of discharges from an 80-MW sub e OTEC plant, the interactions between the discharges from two adjacent 40-MW sub e OTEC plants, and the effects of coastal boundary and bottom discharge were examined with respect to the regional influence of a 40-MW sub e OTEC plant located in deep water off a coast (base case).

  6. Remote wind stress influence on mean sea level in a subtropical coastal region

    Directory of Open Access Journals (Sweden)

    Mabel Calim Costa

    2012-09-01

    Full Text Available The purpose of this study was to assess the relative influence of remote wind stress on mean sea level (MSL variations in the coastal region of Cananeia (Sao Paulo State, Southern Brazil during the period from 1/1/1955 to 12/31/1993. An optimized low-pass Thompson filter for the study area, and spectral analysis (cross spectrum, coherence and phase lag of the relationship between the MSL and both parallel (T// and perpendicular (T| wind stress components were applied. These were extracted from four grid points of the NCEP/NCAR global model. The predominance of annual oscillations as those of greatest coherence and energy, of periods of approximately 341 days (frequency of 0.00293 cpd and 410 days (frequency of 0.00244 cpd, respectively, were observed. Offshore NCEP/NCAR grid points were those with the highest coherence and energy throughout the study in relation to the observed MSL. This may be linked to the restriction of the NCEP/NCAR model as regards the inland limit. It is also concluded that remote wind stress may play an important role in several MSL time scales, including the annual ones. Based on criteria such as coherence and energy peaks, the wind stress component of greatest effect on MSL was the parallel one.O presente estudo tem por objetivo avaliar a influência relativa de tensão do vento remoto na variação do nível médio do mar (NMM para a região costeira de Cananéia (SP durante o período de 1/1/1955 a 31/12/1993. Foram aplicados um filtro de passa-baixa de Thompson (1983, otimizado para a região de Cananéia, além de análise espectral (espectro cruzado, coerência e defasagem entre o NMM e as componentes paralela (T// e perpendicular (T| da tensão do vento. Estas foram extraídas de quatro pontos de grade do modelo global NCEP/NCAR. Observou-se a predominância das oscilações anuais como aquelas de maior coerência e energia, destacando-se os períodos de aproximadamente 341 dias (frequência de 0,00293 cpd e 410

  7. The Large-Scale Oscillations Influence Over the Interdecadal Climate Variability in Mexico's Central Region

    Science.gov (United States)

    Jofre, R.; Brito-Castillo, L.; Tereshchenko, I.; Atmospheric Sciences Climatology Climate Variability

    2013-05-01

    Climate in the highlands of Mexico displays high variability due to its complex terrain and elevation. The knowledge to elucidate the principal forcings of these variations can be useful for forecasting annual and seasonal temperature and precipitation over this area. Due to its complexity a small area in the highlands was delimited with defined physical boundaries, encompassing several states of Mexico. The study area was defined as Mexico's Central Region (MCR), which is located between 19.5 ° - 22.5 ° N and 98.5 ° - 104 ° W. Most of this area overlies the plateau of Anahuac, whose physical boundaries extend to the north from the "Sierras Transversales" (composed by the "Sierra de Zacatecas", the "Sierra de la "Breña" and the "Sierra de San Luis") to the "Eje Neovolcánico" to the south; east and west boundaries are confined by the "Sierra Madre Oriental" and the "Sierra Madre Occidental", respectively. Daily data of maximum and minimum temperature and precipitation series from a total of 112 weather stations were obtained from CLICOM and ERICIII databases. Several climatic indices with average periods of phase oscillations greater than five years, such as the Pacific Decadal Oscillation (PDOI), the Atlantic Multidecadal Oscillation (AMOI), The Arctic Oscillation (AOI), the North Atlantic Oscillation (NAOI), and Aleutian Low Pressure (ALPI) on a monthly basis for all series, except the ALPI series which is on annual rate, were also used in this study. Indices data were obtained from the web site http://www.cicimar.ipn.mx/oacis/Indices_Climaticos.php/. The common period of all series was 1961-2000. We applied Principal Component Analysis to precipitation and temperature series to identify the principal modes of variation of the series. The first mode explained more than 68% of the variance in the original series and corresponds to annual variations. Contour maps were useful to elucidate that temperature variations are highly correlated with the terrain

  8. Evaluation of the Analysis Influence on Transport in Reanalysis Regional Water Cycles

    Science.gov (United States)

    Bosilovich, M. G.; Chen, J.; Robertson, F. R.

    2011-01-01

    Regional water cycles of reanalyses do not follow theoretical assumptions applicable to pure simulated budgets. The data analysis changes the wind, temperature and moisture, perturbing the theoretical balance. Of course, the analysis is correcting the model forecast error, so that the state fields should be more aligned with observations. Recently, it has been reported that the moisture convergence over continental regions, even those with significant quantities of radiosonde profiles present, can produce long term values not consistent with theoretical bounds. Specifically, long averages over continents produce some regions of moisture divergence. This implies that the observational analysis leads to a source of water in the region. One such region is the Unite States Great Plains, which many radiosonde and lidar wind observations are assimilated. We will utilize a new ancillary data set from the MERRA reanalysis called the Gridded Innovations and Observations (GIO) which provides the assimilated observations on MERRA's native grid allowing more thorough consideration of their impact on regional and global climatology. Included with the GIO data are the observation minus forecast (OmF) and observation minus analysis (OmA). Using OmF and OmA, we can identify the bias of the analysis against each observing system and gain a better understanding of the observations that are controlling the regional analysis. In this study we will focus on the wind and moisture assimilation.

  9. Trans-European transport networks influence on the regional development and urban systems: Serbian experience

    Directory of Open Access Journals (Sweden)

    Maksin-Mićić Marija

    2004-01-01

    Full Text Available The trans-European transport network has different effects at macro regional mezzo-regional and micro-regional level, and its effectiveness rises with the lower regional levels. Possible approaches to the trans-European transport network impact and effect survey and policy options have been pointed out. The importance of increased accessibility and mobility for regional expansion and for a more balanced and polycentric system of city networks has been underlined. Changes in the spatial organization utilization and structure of cities, as well as in social benefits and losses subsequent to impacts of trans-European transport corridor "X" section Belgrade-Niš have been analyzed. The new trans-European or major transport infrastructure does not per se create regional and urban system network development, although it can affect the conditions for the processes that create growth and development. The effects can be increased by co-ordination of measures of regional, spatial and urban policy, land use transport, environmental and other policies. The necessary measure is the introduction of spatial impact assessment as sartorial policy instrument for the large transport infrastructure plans and projects.

  10. Influence of European Structural Funds on Social and Economic Performance in Spanish and Portuguese Regions

    OpenAIRE

    Piecuch, Jakub

    2006-01-01

    Spanish and Portuguese regions make up a distinct area in the European Community. Majority of them can be described as less developed economies with strong dependence on agricultural production. The position of those regions is somehow underprivileged due to their peripherality as well as topographic restrictions, which cause integration problems with the common market. In many of these areas of the Iberian Peninsula, small- scale and low tech agriculture still dominates. In most cases these ...

  11. Separated influence of crude oil prices on regional natural gas import prices

    International Nuclear Information System (INIS)

    This paper analyses the impact of global economic activity and international crude oil prices on natural gas import prices in three major natural gas markets using the panel cointegration model. It also investigates the shock impacts of the volatility and the increase and decrease of oil prices on regional natural gas import prices. The results show that both global economic activity and international crude oil prices have significant long-term positive effects on regional natural gas import prices. The volatility of international crude oil prices has a negative impact on regional natural gas import prices. The shock impact is weak in North America, lags in Europe and is most significant in Asia, which is mainly determined by different regional policies for price formation. In addition, the response of natural gas import prices to increases and decreases in international crude oil prices shows an asymmetrical mechanism, of which the decrease impact is relatively stronger. - Highlights: • Impacts of world economy and oil prices on regional natural gas prices are analysed • North American natural gas prices are mainly affected by world economy • Asian and European natural gas prices are mainly affected by oil prices • The volatility of oil prices has a negative impact on regional natural gas prices • The response of natural gas import prices to oil prices up and down shows asymmetry

  12. Influence of moisture content, rate of loading and height regions on tensile strength of alfalfa stems

    Directory of Open Access Journals (Sweden)

    2009-03-01

    Full Text Available The objective of this study was to determine tensile strength of alfalfa stems as a function of moisture content, rate of loading and height region. Information on the physical and mechanical properties of alfalfa stem is important for the design of machines such as mowers, balers and choppers. The experiments were conducted at four moisture levels of 10, 20, 40, and 80% w.b., and three rates of loading of 5, 10 and 20 mm min-1. Each alfalfa stem was divided equally into three height regions, as upper, middle and lower. The tensile strength increased exponentially with decrease in the moisture content and towards the lower regions. The values of the tensile strength were within 9.24-26.35, 16.31-32.74, and 28.88-43.82MPa for the upper, middle and lower regions, respectively, at the different moisture contents studied and 10 mm min-1 rate of loading. The tensile strength increased linearly with increases in the rate of loading for all the regions. Its values varied between 9.24-12.27, 16.31-20.46, and 28.80-32.75 MPa for the upper, middle and lower regions, respectively, with increases in the rate of loading from 5 to 20 mm min-1, at the moisture content of 80% w.b.

  13. Evaluation in femoral neck fracture scintimetry: modes of region of interest selection and influence on results

    International Nuclear Information System (INIS)

    Different sized ROIs within the femoral head and different modes of calculation were used in [/sup 99m/Tc]MDP scintimetry after femoral neck fracture. In preoperative scintimetry, correction for increased trochanteric uptake gave the best discrimination, whereas in postoperative scintimetry the direct ratio fractured/intact femoral head was superior. The change in ROI size had little influence

  14. Influence of transport infrastructure on the industrial development of the Russian regions

    Directory of Open Access Journals (Sweden)

    Elizaveta Eduardovna Kolchinskaya

    2015-06-01

    Full Text Available Objective to build a model describing the relationship between the level of transport infrastructure development of the region and the level of industrial development in the region. Methods calculation of the integral indicators of a particular industry development regression analysis method of the production function constructing. For regression analysis the paper uses panel data models with random and fixed effects and the pooled panel data model. To check the quality of the regression model the Fisher and Student ttests were used. To test the model for heteroskedastic properties tests by Park Glazer GoldfeldQuandt and White were applied. Results models of linear and logarithmic specifications with random and fixed effects were built as well as pooled panel data models. Significant coefficients of transport infrastructure indicators were obtained in both cases only in the pooled panel data models. The model which considered the railway density index as one of the characteristics of the transport infrastructure of the region showed the negative coefficient of this variable. Scientific novelty for the first time on the basis of Russian regions statistics using regression models of panel data the dependence has been studied between the level of transport development in the region and the dynamics of industrial production in it. As the characteristic of transport infrastructure development the specially designed integral indicator was used i.e. the transport enterprises and communications functioning in the region summarizing several characteristics of enterprises in the industry. Practical value the obtained results can be used to predict effects of adopting decisions on improving the transport infrastructure in the Russian Federation regions. The results and conclusion can serve as a basis for further research on this topic and be applied in the characterization of the Russian economy. In addition the results can be used in the educational

  15. Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: Pathological significance in early- and late-onset breast carcinoma

    Directory of Open Access Journals (Sweden)

    Roychoudhury Susanta

    2008-11-01

    Full Text Available Abstract Introduction Younger women with breast carcinoma (BC exhibits more aggressive pathologic features compared to older women; young age could be an independent predictor of adverse prognosis. To find any existing differences in the molecular pathogenesis of BC in both younger and older women, alterations at chromosomal (chr. 9q22.32-22.33 region were studied owing to its association in wide variety of tumors. Present work focuses on comparative analysis of alterations of four candidate genes; PHF2, FANCC, PTCH1 and XPA located within 4.4 Mb region of the afore-said locus in two age groups of BC, as well as the interrelation and prognostic significance of alterations of these genes. Methods Deletion analysis of PHF2, FANCC, PTCH1 and XPA were examined in a subset of 47 early-onset (group-A: ≤ 40 years and 59 late-onset (group-B: > 40 years breast carcinomas using both microsatellite and exonic markers. Methylation Sensitive Restriction analysis (MSRA was done to check for promoter methylation. Quantitative real-time polymerase chain reaction (Q-PCR and immunohistochemisty (IHC was done in some genes to see their relative mRNA and protein expressions respectively. Clinico-pathological correlation of different parameters as well as patient survival was calculated using different statistical softwares like EpiInfo 6.04b, SPSS 10.0 etc. Results Either age group exhibited high frequency of overall alterations in PHF2, FANCC and PTCH1 compared to XPA. Samples with alteration (deletion/methylation in these genes showed reduced level of mRNA expression as seen by Q-PCR. Immunohistochemical analysis of FANCC and PTCH1 also supported this observation. Poor patient survival was noted in both age groups having alterations in FANCC. Similar result was also seen with PTCH1 and XPA alterations in group-A and PHF2 alterations in group-B. This reflected their roles as prognostic tools in the respective groups in which they were altered. Conclusion Overall

  16. Does regional anesthesia influence early outcome of upper arm arteriovenous fistula?

    International Nuclear Information System (INIS)

    To assess the effect of regional anesthesia on the outcome of elbow arteriovenous fistula (AVF), prospectively studied consecutive patients with end-stage renal disease referred for permanent vascular access to the Vascular Unit of King Fahd University Hospital between September 2004 and September 2007. The patients were divided into 2 groups: Group 1: patients who underwent the construction of the AVF under regional anesthesia and Group 2: patients who were operated under general anesthesia, indicated by their preferences or failure of regional anesthesia. Data including patient characteristics and type of AVF were recorded. The internal diameter of the vein and the artery and intra-operative blood flow were measured. The complications of both types of anesthesia were recorded. The patients were followed up for three months. Eighty four cases were recruited in this study. Complete brachial plexus block was achieved in 57 (68%) patients. Seven patients were converted to general anesthesia and 20 patients had AVF under general anesthesia from the start. There were no significant differences between the 2 groups with regard to basic characteristics or operative data. There were no instances of systemic toxicity, hematomas, or nerve injury from the regional block. No major complications were reported from the general anesthesia. There was no significant difference between both groups regarding early failure of AVF (Group 1, 14% vs. Group2; 11%. P= 0.80). No significant advantage of regional over general anesthesia in terms of early outcome of AVF was seen in this study (Author).

  17. Influence of climate modes on tropical cyclone formation in the Australian region

    Science.gov (United States)

    Werner, A.

    2010-08-01

    Relationships between tropical cyclogenesis (TCG) in the Australian region and modes of various atmospheric and oceanic parameters are investigated for the period 1968-2006. Seven thermal and seven dynamic variables describing the state of moisture transport and wind flow patterns in the atmosphere were analysed. In order to identify the dominant modes of each variable, an empirical orthogonal function (EOF) is applied. The three leading modes of each variable were then considered. This study corroborates previous work showing that El Niño-Southern Oscillation (ENSO) is the leading contributor to TCG in the all-Australian, Western and Eastern Australian regions. The ENSO-linked first EOF of the streamfunction at sigma level 0.2101 shows the strongest relationship with TCG variations in the all-Australian and Eastern regions correlating at 0.73 and 0.62, respectively. In the western Australian region, the first EOF of environmental vertical wind shear shows the strongest skill. TCG frequency in the Northern region is mainly affected by the large-scale wind patterns of the subtropics and mid-latitudes such as the subtropical jet and the Rossby wave train.

  18. The Influence of Land Surface Changes on Regional Climate in Northwest China

    Institute of Scientific and Technical Information of China (English)

    XU Xingkui; ZHANG Feng; Jason K.LEVY

    2007-01-01

    Land surface changes effect the regional climate due to the complex coupling of land-atmosphere interactions. From 1995 to 2000, a decrease in the vegetation density and an increase in ground-level thermodynamic activity has been documented by multiple data sources in Northwest China, including meteorological, reanalysis from European Centre for Medium-Range Weather Forecasts (ECMWF), National Oceanic and Atmospheric Administration's (NOAA) Advanced Very High Resolution Radiometer (AVHRR) and TIROS Operational Vertical Sounder (TOVS) satellite remote sensing data. As the ground-level thermodynamic activity increases, humid air from the surrounding regions converge toward desert (and semi-desert) regions, causing areas with high vegetation cover to become gradually more arid. Furthermore, land surface changes in Northwest China are responsible for a decrease in total cloud cover, a decline in the fraction of low and middle clouds, an increase in high cloud cover (due to thermodynamic activity) and other regional climatic adaptations. It is proposed that, beginning in 1995, these cloud cover changes contributed to a "greenhouse" effect, leading to the rapid air temperature increases and other regional climate impacts that have been observed over Northwest China.

  19. Influence of climate modes on tropical cyclone formation in the Australian region

    International Nuclear Information System (INIS)

    Relationships between tropical cyclogenesis (TCG) in the Australian region and modes of various atmospheric and oceanic parameters are investigated for the period 1968-2006. Seven thermal and seven dynamic variables describing the state of moisture transport and wind flow patterns in the atmosphere were analysed. In order to identify the dominant modes of each variable, an empirical orthogonal function (EOF) is applied. The three leading modes of each variable were then considered. This study corroborates previous work showing that El Nino-Southern Oscillation (ENSO) is the leading contributor to TCG in the all-Australian, Western and Eastern Australian regions. The ENSO-linked first EOF of the streamfunction at sigma level 0.2101 shows the strongest relationship with TCG variations in the all-Australian and Eastern regions correlating at 0.73 and 0.62, respectively. In the western Australian region, the first EOF of environmental vertical wind shear shows the strongest skill. TCG frequency in the Northern region is mainly affected by the large-scale wind patterns of the subtropics and mid-latitudes such as the subtropical jet and the Rossby wave train.

  20. Regional analysis of groundwater nitrate concentrations and trends in Denmark in regard to agricultural influence

    DEFF Research Database (Denmark)

    Hansen, B.; Dalgaard, Tommy; Thorling, L.;

    2012-01-01

    The act of balancing between an intensive agriculture with a high potential for nitrate pollution and a drinking water supply almost entirely based on groundwater is a challenge faced by Denmark and similar regions around the globe. Since the 1980s, regulations implemented by Danish farmers have...... trends according to data sampled from 1988–2009. A regional analysis shows a correlation between a high level of N surplus in agriculture, high concentrations of nitrate in groundwater and the largest number of downward nitrate trends in groundwater in the livestock-dense northern and western parts of...... Denmark compared with the southeastern regions with lower livestock densities. These results indicate that the livestock farms dominating in northern and western parts of Denmark have achieved the largest reductions in N surpluses. Groundwater recharge age determinations allow comparison of long...

  1. Inversion of Gravity Data to Define the Pre-Cenozoic Surface and Regional Structures Possibly Influencing Groundwater Flow in the Rainier Mesa Region, Nye County, Nevada.

    Energy Technology Data Exchange (ETDEWEB)

    Thomas G. Hildenbrand; Geoffrey A. Phelps; Edward A. Mankinen

    2006-09-21

    A three-dimensional inversion of gravity data from the Rainier Mesa area and surrounding regions reveals a topographically complex pre-Cenozoic basement surface. This model of the depth to pre-Cenozoic basement rocks is intended for use in a 3D hydrogeologic model being constructed for the Rainier Mesa area. Prior to this study, our knowledge of the depth to pre-Cenozoic basement rocks was based on a regional model, applicable to general studies of the greater Nevada Test Site area but inappropriate for higher resolution modeling of ground-water flow across the Rainier Mesa area. The new model incorporates several changes that lead to significant improvements over the previous regional view. First, the addition of constraining wells, encountering old volcanic rocks lying above but near pre-Cenozoic basement, prevents modeled basement from being too shallow. Second, an extensive literature and well data search has led to an increased understanding of the change of rock density with depth in the vicinity of Rainier Mesa. The third, and most important change, relates to the application of several depth-density relationships in the study area instead of a single generalized relationship, thereby improving the overall model fit. In general, the pre-Cenozoic basement surface deepens in the western part of the study area, delineating collapses within the Silent Canyon and Timber Mountain caldera complexes, and shallows in the east in the Eleana Range and Yucca Flat regions, where basement crops out. In the Rainier Mesa study area, basement is generally shallow (< 1 km). The new model identifies previously unrecognized structures within the pre-Cenozoic basement that may influence ground-water flow, such as a shallow basement ridge related to an inferred fault extending northward from Rainier Mesa into Kawich Valley.

  2. Influence of building orientation on internal temperature in saharan climates, building located in Ghardaïa region (Algeria

    Directory of Open Access Journals (Sweden)

    Bekkouche Sidi Mohammed El Amine

    2013-01-01

    Full Text Available In desert regions, the orientation of buildings has an important influence in the inside air temperature. In the present work, we carry out a study on the influence of the buildings orientation as well as the thermal insulation on the internal temperature. To do so, we have considered the case where only the exposed walls are isolated. The main objective of the current work is to determine the temperatures of the building in question with and without thermal insulation. This study aims at assessing also the geographic parameter enhancing or damping the role of thermal inertia, providing a variety of results. As result, this work proves that stones play a contradictory role on thermal comfort. We have verified that thermal insulation is specified to reduce heat transfer through the building. Concerning the orientation, results indicates that the variation in orientation does not influence significantly the internal air temperature of a well thermally insulated building. Moreover, in hot period, whatever orientation considered, the phenomenon of overheating presents a serious problem to minimize consumption of energy and control of indoor temperature in case of building without insulation. The numerical data was compared to the experimental measurements in order to validate the mathematical model. In conclusion, to achieve a better thermal comfort arid and semi arid regions, the habitation will have to be situated in south flan of a hill to satisfy the two strategies (hot and cold.

  3. Influencing factors on regional differences in glyphosate use in North German arable farming

    OpenAIRE

    Andert, Sabine; Bürger, Jana; Gerowitt, Bärbel

    2016-01-01

    Glyphosate is the worldwide mostly used herbicide substance. Glyphosate use in arable cropping is under strong discussion in scientific and public communities. In the present study, we investigated the use of glyphosate from 15 farms in four districts in North German arable farming from 2005 until 2014. Objective of our research is to reveal influencing factors on glyphosate use intensity. The farm structures differ between two West districts (Diepholz, Uelzen) and two East districts (Fläm...

  4. Study of the influence of solar variability on a regional (Indian) climate: 1901-2007

    OpenAIRE

    Aslam, O. P. M.; Badruddin

    2014-01-01

    We use Indian temperature data of more than 100 years to study the influence of solar activity on climate. We study the Sun-climate relationship by averaging solar and climate data at various time scales; decadal, solar activity and solar magnetic cycles. We also consider the minimum and maximum values of sunspot number (SSN) during each solar cycle. This parameter SSN is correlated better with Indian temperature when these data are averaged over solar magnetic polarity epochs (SSN maximum to...

  5. The influence of the ocean and the stratosphere on climate persistence in the North Atlantic region

    OpenAIRE

    Breiteig, Tarjei

    2009-01-01

    The North Atlantic Oscillation (NAO) is generally regarded to largely be a product of processes internal to the troposphere. This thesis investigates various aspects of how the NAO and related climatical fields are influenced by two of the tropospheric boundary components; the stratosphere above and the ocean below. The thesis consists of five manuscripts, three considering the role of the stratosphere, and two considering the role of the ocean. Data provided by the NCEP/NCA...

  6. Dark matter candidates

    International Nuclear Information System (INIS)

    One of the simplest, yet most profound, questions we can ask about the Universe is, how much stuff is in it, and further what is that stuff composed of? Needless to say, the answer to this question has very important implications for the evolution of the Universe, determining both the ultimate fate and the course of structure formation. Remarkably, at this late date in the history of the Universe we still do not have a definitive answer to this simplest of questions---although we have some very intriguing clues. It is known with certainty that most of the material in the Universe is dark, and we have the strong suspicion that the dominant component of material in the Cosmos is not baryons, but rather is exotic relic elementary particles left over from the earliest, very hot epoch of the Universe. If true, the Dark Matter question is a most fundamental one facing both particle physics and cosmology. The leading particle dark matter candidates are: the axion, the neutralino, and a light neutrino species. All three candidates are accessible to experimental tests, and experiments are now in progress. In addition, there are several dark horse, long shot, candidates, including the superheavy magnetic monopole and soliton stars. 13 refs

  7. Investigating the influence of regional climate and oceanography on marine radiocarbon reservoir ages in southwest New Zealand

    Science.gov (United States)

    Hinojosa, Jessica L.; Moy, Christopher M.; Prior, Christine A.; Eglinton, Timothy I.; McIntyre, Cameron P.; Stirling, Claudine H.; Wilson, Gary S.

    2015-12-01

    The New Zealand fjords are located at a latitude where distinct oceanic and atmospheric fronts separate carbon reservoirs of varying residence time. The marine radiocarbon reservoir age in this region is likely to deviate from the global average reservoir age over space and time as frontal boundaries migrate north and south. Here we present new estimates of modern radiocarbon reservoir age using the radiocarbon content of bivalve shells collected live before 1950. Multiple measurements from hydrographically distinct sites support the use of a ΔR, defined as the regional offset between measured and modeled marine radiocarbon reservoir age, of 59 ± 35 years for the New Zealand fjords. We also assess the radiocarbon content of bulk surface sediments throughout the fjord region. Sediment with a higher proportion of marine organic carbon has relatively less radiocarbon than more terrestrial sediment, suggesting a short residence time of organic carbon on land before deposition in the fjords. Additionally, we constrain reservoir age variability throughout the Holocene using coeval terrestrial and marine macrofossils. Although our modern results suggest spatial consistency in ΔR throughout the fjords, large deviations from the global average marine radiocarbon reservoir age exist in the paleo record. We find four ancient ΔR values, extending back to ˜10.2 cal kyr BP, to be negative or near zero. A likely cause of younger radiocarbon reservoir ages at select intervals throughout the Holocene is the increased influence of the Southern Hemisphere westerly winds, which cause extreme precipitation in the region that delivers terrestrial carbon, enriched in radiocarbon, to fjord basins. However, bivalve depth habitat may also influence radiocarbon content due to a stratified water column containing distinct carbon pools. This work highlights the need for thorough assessment of local radiocarbon cycling in similar regions of dynamic ocean/atmosphere frontal zones

  8. Characterization of mesostasis regions in lunar basalts: Understanding late-stage melt evolution and its influence on apatite formation

    Science.gov (United States)

    Potts, Nicola J.; TartèSe, Romain; Anand, Mahesh; Westrenen, Wim; Griffiths, Alexandra A.; Barrett, Thomas J.; Franchi, Ian A.

    2016-07-01

    Recent studies geared toward understanding the volatile abundances of the lunar interior have focused on the volatile-bearing accessory mineral apatite. Translating measurements of volatile abundances in lunar apatite into the volatile inventory of the silicate melts from which they crystallized, and ultimately of the mantle source regions of lunar magmas, however, has proved more difficult than initially thought. In this contribution, we report a detailed characterization of mesostasis regions in four Apollo mare basalts (10044, 12064, 15058, and 70035) in order to ascertain the compositions of the melts from which apatite crystallized. The texture, modal mineralogy, and reconstructed bulk composition of these mesostasis regions vary greatly within and between samples. There is no clear relationship between bulk-rock basaltic composition and that of bulk-mesostasis regions, indicating that bulk-rock composition may have little influence on mesostasis compositions. The development of individual melt pockets, combined with the occurrence of silicate liquid immiscibility, exerts greater control on the composition and texture of mesostasis regions. In general, the reconstructed late-stage lunar melts have roughly andesitic to dacitic compositions with low alkali contents, displaying much higher SiO2 abundances than the bulk compositions of their host magmatic rocks. Relevant partition coefficients for apatite-melt volatile partitioning under lunar conditions should, therefore, be derived from experiments conducted using intermediate compositions instead of compositions representing mare basalts.

  9. Influences of the Learning Environment of a Regional University Campus on its International Graduates

    Science.gov (United States)

    Ellis, Bronwyn; Sawyer, Janet; Gill, Rod; Medlin, John; Wilson, Digby

    2005-01-01

    Staff and students at small regional campuses often consider them to be a learning environment with many advantages. Students can benefit from the opportunities for enhanced access to staff provided by factors such as small classes and a compact campus. International students from non-English-speaking backgrounds are one group for whom these…

  10. The Influence of Filaments in the Private Flux Region on Divertor Particle and Power Deposition

    CERN Document Server

    Harrison, J R; Thornton, A J; Walkden, N R

    2015-01-01

    The transport of particles via intermittent filamentary structures in the private flux region of plasmas in the MAST tokamak has been investigated using a fast framing camera recording visible light emission from the volume of the lower divertor, as well as Langmuir probes and IR thermography monitoring particle and power fluxes to plasma-facing surfaces in the divertor. The visible camera data suggests that, in the divertor volume, fluctuations in light emission above the X-point are strongest in the scrape-off layer (SOL). Conversely, in the region below the X-point, it is found that these fluctuations are strongest in the private flux region (PFR) of the inner divertor leg. Detailed analysis of the appearance of these filaments in the camera data suggests that they are approximately circular, around 1-2cm in diameter. The most probable toroidal mode number is between 2 and 3. These filaments eject plasma deeper into the private flux region, sometimes by the production of secondary filaments, moving at a sp...

  11. Climate Change Effects on Precipitation Extremes over Europe Evaluated by the Region-of-Influence Method

    Czech Academy of Sciences Publication Activity Database

    Gaál, Ladislav; Beranová, Romana; Kyselý, Jan

    Phoenix: American Meteorological Society, 2015. s. 64. [AMS Annual Meeting /95./ and Conference on Climate Variability and Change /27./. 04.01.2015–08.01.2015, Phoenix] Institutional support: RVO:68378289 Keywords : precipitation extremes * regional climate model simulations Subject RIV: DG - Athmosphere Sciences, Meteorology https://ams.confex.com/ams/95Annual/webprogram/Paper257799.html

  12. When it matters how you pronounce it: the influence of regional accents on job interview outcome.

    Science.gov (United States)

    Rakić, Tamara; Steffens, Melanie C; Mummendey, Amélie

    2011-11-01

    The visual dimension has featured prominently in person perception in the last 25 years. Alone, this dimension cannot give the complete 'picture' of others because language and speech (i.e., the auditory dimension) are also highly informative. Social-cognition research investigates the role of auditory information for impression formation. In a series of experiments, we tested perceived competence, hirability, and socio-intellectual status of different targets based on their regional accents. Given identical content of statements in different conditions of an alleged job interview, regional German accents (Saxon, Bavarian, and Berlin) resulted in lower perceived competence and hirability than standard German, even though the Bavarian accent at the same time resulted in higher ratings of socio-intellectual status compared to other regional accents (Experiment 1). These findings were confirmed when using a broader population sample and a 'matched guise' technique (Experiment 2). Our findings indicate that regional accents, similar to faces, can be very powerful in creating differentiated pictures of individuals. PMID:21988389

  13. Influence of coal mining on environmental status in the Ostrava-Karvina region

    International Nuclear Information System (INIS)

    The Ostrava-Karvina region is one of the most highly industrialized regions in Czechoslovakia, and it is considered to be one of the most adversely affected areas so far as environmental quality is concerned. More than 100 years of coal mining and the consequent development of heavy industries in the greater Ostrava region have led not only to extensive damage of the landscape, but also to a significant degree of air and water pollution. Today, the environmental damages can be observed not only in the industrial belt, but also in the Frydek-Mistek and Trinec to environmental problems are such industries as steel plants, coke oven batteries, power plants, an chemical factories. the region produces about 20% of the gross industrial production of the Czech Republic, although only 7% of the population lives there. Before the 1970s, environmental protection and control were not subjects of serious though in Czechoslovakia. Although some pioneering work began in the early 1970s, political changes in 1989 considerably eased the way to understanding the situation and planning for the future. The present paper highlights the current problems and shows future directions in environmental protection and control in the mining sector

  14. Climatic variability of river outflow in the Pantanal region and the influence of sea surface temperature

    Science.gov (United States)

    Silva, Carlos Batista; Silva, Maria Elisa Siqueira; Ambrizzi, Tércio

    2016-03-01

    This paper investigates possible linear relationships between climate, hydrology, and oceanic surface variability in the Pantanal region (in South America's central area), over interannual and interdecadal time ranges. In order to verify the mentioned relations, lagged correlation analysis and linear adjustment between river discharge at the Pantanal region and sea surface temperature were used. Composite analysis for atmospheric fields, air humidity flux divergence, and atmospheric circulation at low and high levels, for the period between 1970 and 2003, was analyzed. Results suggest that the river discharge in the Pantanal region is linearly associated with interdecadal and interannual oscillations in the Pacific and Atlantic oceans, making them good predictors to continental hydrological variables. Considering oceanic areas, 51 % of the annual discharge in the Pantanal region can be linearly explained by mean sea surface temperature (SST) in the Subtropical North Pacific, Tropical North Pacific, Extratropical South Pacific, and Extratropical North Atlantic over the period. Considering a forecast approach in seasonal scale, 66 % of the monthly discharge variance in Pantanal, 3 months ahead of SST, is explained by the oceanic variables, providing accuracy around 65 %. Annual discharge values in the Pantanal region are strongly related to the Pacific Decadal Oscillation (PDO) variability (with 52 % of linear correlation), making it possible to consider an interdecadal variability and a consequent subdivision of the whole period in three parts: 1st (1970-1977), 2nd (1978-1996), and 3rd (1997-2003) subperiods. The three subperiods coincide with distinct PDO phases: negative, positive, and negative, respectively. Convergence of humidity flux at low levels and the circulation pattern at high levels help to explain the drier and wetter subperiods. During the wetter 2nd subperiod, the air humidity convergence at low levels is much more evident than during the other two

  15. The variability of biomass burning and its influence on regional aerosol properties during the wheat harvest season in North China

    Science.gov (United States)

    Wang, Lili; Xin, Jinyuan; Li, Xingru; Wang, Yuesi

    2015-04-01

    The spatial-temporal variation of biomass burning in June during the wheat harvest season in the North China (32-41°N, 111-120°E) and its influence on the regional aerosol optical depth (AOD) and the chemical compositions of size-segregated aerosols in the urban environment were investigated to evaluate the effectiveness of the burn ban policy and the influence on regional pollution. Fire events that occurred in early and middle June accounted for approximately 89% of the events during the month, and fire points located in mid-eastern China (32.5-35.5°N, 114-120°E) comprised 71%. The occurrences exhibit oscillatory changes with a minimum in 2008 (during the Beijing Olympics) and a peak and explosive growth in 2012. Under high relative humidity and south winds, fire emissions from straw burning combined with high urban/industrial emissions to produce intensive regional haze pollution in the North Plain. The formation of secondary inorganic particles was intensified due to the interactions of smoke plumes and urban/industrial pollutants in an urban environment. Higher concentrations and percentages (79%) of sulfate, nitrate, ammonium, and organic carbon in the fine particles under high relative humidity conditions contributed to a deteriorated urban visibility. Therefore, stronger management and a comprehensive ban on wheat straw burning in June are urgently needed, especially during years when the south wind is dominant.

  16. The influence of regional Arctic sea-ice decline on stratospheric and tropospheric circulation

    Science.gov (United States)

    McKenna, Christine; Bracegirdle, Thomas; Shuckburgh, Emily; Haynes, Peter

    2016-04-01

    Arctic sea-ice extent has rapidly declined over the past few decades, and most climate models project a continuation of this trend during the 21st century in response to greenhouse gas forcing. A number of recent studies have shown that this sea-ice loss induces vertically propagating Rossby waves, which weaken the stratospheric polar vortex and increase the frequency of sudden stratospheric warmings (SSWs). SSWs have been shown to increase the probability of a negative NAO in the following weeks, thereby driving anomalous weather conditions over Europe and other mid-latitude regions. In contrast, other studies have shown that Arctic sea-ice loss strengthens the polar vortex, increasing the probability of a positive NAO. Sun et al. (2015) suggest these conflicting results may be due to the region of sea-ice loss considered. They find that if only regions within the Arctic Circle are considered in sea-ice projections, the polar vortex weakens; if only regions outwith the Arctic Circle are considered, the polar vortex strengthens. This is because the anomalous Rossby waves forced in the former/latter scenario constructively/destructively interfere with climatological Rossby waves, thus enhancing/suppressing upward wave propagation. In this study, we investigate whether Sun et al.'s results are robust to a different model. We also divide the regions of sea-ice loss they considered into further sub-regions, in order to examine the regional differences in more detail. We do this by using the intermediate complexity climate model, IGCM4, which has a well resolved stratosphere and does a good job of representing stratospheric processes. Several simulations are run in atmosphere only mode, where one is a control experiment and the others are perturbation experiments. In the control run annually repeating historical mean surface conditions are imposed at the lower boundary, whereas in each perturbation run the model is forced by SST perturbations imposed in a specific

  17. Assessing the influence of watershed characteristics on chlorophyll a in waterbodies at global and regional scales

    Science.gov (United States)

    Woelmer, Whitney; Kao, Yu-Chun; Bunnell, David; Deines, Andrew M.; Bennion, David; Rogers, Mark W.; Brooks, Colin N.; Sayers, Michael J.; Banach, David M.; Grimm, Amanda G.; Shuchman, Robert A.

    2016-01-01

    Prediction of primary production of lentic water bodies (i.e., lakes and reservoirs) is valuable to researchers and resource managers alike, but is very rarely done at the global scale. With the development of remote sensing technologies, it is now feasible to gather large amounts of data across the world, including understudied and remote regions. To determine which factors were most important in explaining the variation of chlorophyll a (Chl-a), an indicator of primary production in water bodies, at global and regional scales, we first developed a geospatial database of 227 water bodies and watersheds with corresponding Chl-a, nutrient, hydrogeomorphic, and climate data. Then we used a generalized additive modeling approach and developed model selection criteria to select models that most parsimoniously related Chl-a to predictor variables for all 227 water bodies and for 51 lakes in the Laurentian Great Lakes region in the data set. Our best global model contained two hydrogeomorphic variables (water body surface area and the ratio of watershed to water body surface area) and a climate variable (average temperature in the warmest model selection criteria to select models that most parsimoniously related Chl-a to predictor variables quarter) and explained ~ 30% of variation in Chl-a. Our regional model contained one hydrogeomorphic variable (flow accumulation) and the same climate variable, but explained substantially more variation (58%). Our results indicate that a regional approach to watershed modeling may be more informative to predicting Chl-a, and that nearly a third of global variability in Chl-a may be explained using hydrogeomorphic and climate variables.

  18. Influence of Atmospheric Solar Radiation Absorption on Photodestruction of Ions at D-Region Altitudes of the Ionosphere

    Science.gov (United States)

    Pavlov, A. V.

    2016-04-01

    The influence of atmospheric solar radiation absorption on the photodetachment, dissociative photodetachment, and photodissociation rate coefficients (photodestruction rate coefficients) of O-, Cl-, O2 -, O3 -, OH-, NO2 -, NO3 -, O4 -, OH-(H2O), CO3 -, CO4 -, ONOO-, HCO3 -, CO3 -(H2O), NO3 -(H2O), O2 +(H2O), O4 +, N4 +, NO+(H2O), NO+(H2O)2, H+(H2O) n for n = 2-4, NO+(N2), and NO+(CO2) at D-region altitudes of the ionosphere is studied. A numerical one-dimensional time-dependent neutral atmospheric composition model has been developed to estimate this influence. The model simulations are carried out for the geomagnetically quiet time period of 15 October 1998 at moderate solar activity over the Boulder ozonesonde. If the solar zenith angle is not more than 90° then the strongest influence of atmospheric solar radiation absorption on photodestruction of ions is found for photodissociation of CO4 - ions when CO3 - ions are formed. It follows from the calculations that decreases in the photodestruction rate coefficients of ions under consideration caused by this influence are less than 2 % at 70 km altitude and above this altitude if the solar zenith angle does not exceed 90°.

  19. Influence of Atmospheric Solar Radiation Absorption on Photodestruction of Ions at D-Region Altitudes of the Ionosphere

    Science.gov (United States)

    Pavlov, A. V.

    2016-07-01

    The influence of atmospheric solar radiation absorption on the photodetachment, dissociative photodetachment, and photodissociation rate coefficients (photodestruction rate coefficients) of O-, Cl-, O2 -, O3 -, OH-, NO2 -, NO3 -, O4 -, OH-(H2O), CO3 -, CO4 -, ONOO-, HCO3 -, CO3 -(H2O), NO3 -(H2O), O2 +(H2O), O4 +, N4 +, NO+(H2O), NO+(H2O)2, H+(H2O) n for n = 2-4, NO+(N2), and NO+(CO2) at D-region altitudes of the ionosphere is studied. A numerical one-dimensional time-dependent neutral atmospheric composition model has been developed to estimate this influence. The model simulations are carried out for the geomagnetically quiet time period of 15 October 1998 at moderate solar activity over the Boulder ozonesonde. If the solar zenith angle is not more than 90° then the strongest influence of atmospheric solar radiation absorption on photodestruction of ions is found for photodissociation of CO4 - ions when CO3 - ions are formed. It follows from the calculations that decreases in the photodestruction rate coefficients of ions under consideration caused by this influence are less than 2 % at 70 km altitude and above this altitude if the solar zenith angle does not exceed 90°.

  20. Regional water quality patterns in an alluvial aquifer: Direct and indirect influences of rivers

    Science.gov (United States)

    Baillieux, A.; Campisi, D.; Jammet, N.; Bucher, S.; Hunkeler, D.

    2014-11-01

    The influence of rivers on the groundwater quality in alluvial aquifers can be twofold: direct and indirect. Rivers can have a direct influence via recharge and an indirect one by controlling the distribution of fine-grained, organic-carbon rich flood deposits that induce reducing conditions. These direct and indirect influences were quantified for a large alluvial aquifer on the Swiss Plateau (50 km2) in interaction with an Alpine river using nitrate as an example. The hydrochemistry and stable isotope composition of water were characterized using a network of 115 piezometers and pumping stations covering the entire aquifer. Aquifer properties, land use and recharge zones were evaluated as well. This information provided detailed insight into the factors that control the spatial variability of groundwater quality. Three main factors were identified: (1) diffuse agricultural pollution sources; (2) dilution processes resulting from river water infiltrations, revealed by the δ18OH2O and δ2HH2O contents of groundwater; and (3) denitrification processes, controlled by the spatial variability of flood deposits governed by fluvial depositional processes. It was possible to quantify the dependence of the nitrate concentration on these three factors at any sampling point of the aquifer using an end-member mixing model, where the average nitrate concentration in recharge from the agricultural area was evaluated at 52 mg/L, and the nitrate concentration of infiltrating river at approximately 6 mg/L. The study shows the importance of considering the indirect and direct impacts of rivers on alluvial aquifers and provides a methodological framework to evaluate aquifer scale water quality patterns.

  1. Study of the influence of solar variability on a regional (Indian) climate: 1901-2007

    CERN Document Server

    Aslam, O P M

    2014-01-01

    We use Indian temperature data of more than 100 years to study the influence of solar activity on climate. We study the Sun-climate relationship by averaging solar and climate data at various time scales; decadal, solar activity and solar magnetic cycles. We also consider the minimum and maximum values of sunspot number (SSN) during each solar cycle. This parameter SSN is correlated better with Indian temperature when these data are averaged over solar magnetic polarity epochs (SSN maximum to maximum). Our results indicate that the solar variability may still be contributing to ongoing climate change and suggest for more investigations.

  2. Influence of Heterogeneous and Distant Radon Sources on Local and Regional Radon Transport

    International Nuclear Information System (INIS)

    This work presents a sample of how considering a complex spatial heterogeneous radon exhalation flux density as a source term in modelling studies, using a receptor-oriented approach, influences the modelling results in comparison with the traditionally used 1atom.cm-2.s-1 radon exhalation flux density over land and 0 atom.cm-2.s-1 over water bodies. Results show that when high accuracy is needed, for instance in validation of atmospheric transport models, the use of an accurate spatial varying radon exhalation flux density gives may significantly improve the modelling results. (author)

  3. A Bivariate Whole Genome Linkage Study Identified Genomic Regions Influencing Both BMD and Bone Structure

    OpenAIRE

    Liu, Xiao-Gang; Liu, Yong-Jun; Liu, Jianfeng; Pei, Yufang; Xiong, Dong-Hai; Shen, Hui; Deng, Hong-Yi; Papasian, Christopher J.; Drees, Betty M.; Hamilton, James J.; Recker, Robert R.; Deng, Hong-Wen

    2008-01-01

    Areal BMD (aBMD) and areal bone size (ABS) are biologically correlated traits and are each important determinants of bone strength and risk of fractures. Studies showed that aBMD and ABS are genetically correlated, indicating that they may share some common genetic factors, which, however, are largely unknown. To study the genetic factors influencing both aBMD and ABS, bivariate whole genome linkage analyses were conducted for aBMD-ABS at the femoral neck (FN), lumbar spine (LS), and ultradis...

  4. Forest cover influence on regional flood frequency assessment in Mediterranean catchments

    Directory of Open Access Journals (Sweden)

    F. Preti

    2011-10-01

    Full Text Available The paper aims at evaluating to what extent the forest cover can explain the component of runoff coefficient as defined in a regional flood frequency analysis based on the application of the rational formula coupled with a regional model of the annual maximum rainfall depths. The analysis is addressed to evaluate the component of the runoff coefficient which cannot be captured by the catchment lithology alone. Data mining is performed on 75 catchments distributed from South to Central Italy. Cluster and correlation structure analyses are conducted for distinguishing forest cover effects within catchments characterized by hydro-morphological similarities. We propose to improve the prediction of the runoff coefficient by a linear regression model, exploiting the ratio of the forest cover to the catchment critical rainfall depth as dependent variable. The proposed regression enables a significant bias correction of the runoff coefficient, particularly for those small mountainous catchments, characterised by larger forest cover fraction and lower critical rainfall depth.

  5. Total and regional fat distribution is strongly influenced by genetic factors in young and elderly twins

    DEFF Research Database (Denmark)

    Malis, Charlotte; Rasmussen, Eva L; Poulsen, Pernille;

    2005-01-01

    major genetic component (h(2)) of total (h(2)(young) = 0.83, h(2)(elderly) = 0.86) and regional fat percentages (trunk, h(2)(young) = 0.82, h(2)(elderly) = 0.85; lower body, h(2)(young) = 0.83, h(2)(elderly) = 0.81; and trunk/lower body, h(2)(young) = 0.83, h(2)(elderly) = 0.71) in both the young and...... and etiologic components of variance were estimated for total and regional fat percentages using biometric modeling. RESULTS: The intraclass correlations demonstrated higher correlations for all fat percentages among monozygotic twins as compared with dizygotic twins. The biometric modeling revealed a...... elderly twins. DISCUSSION: The h(2) estimates emphasize that body fat and distribution as determined by DXA scan are under extensive genetic control....

  6. What Factors Influence Firm Perceptions of Labour Market Constraints to Growth in the MENA Region?

    OpenAIRE

    Fakih, Ali; Ghazalian, Pascal L.

    2015-01-01

    Labour market constraints constitute prominent obstacles to firm development and economic growth of countries located in the Middle East and North Africa (MENA) region. This paper aims at examining the implications of firm characteristics, national locations, and sectoral associations for the perceptions of firms concerning two basic labour market constraints: labour regulations and labour skill shortages. The empirical analysis is carried out using firm-level dataset sourced from the World B...

  7. Influence of ecohydrologic feedbacks from simulated crop growth on integrated regional hydrologic simulations under climate scenarios

    OpenAIRE

    Walsum, P. E. V.; Supit, I.

    2012-01-01

    Hydrologic climate change modelling is hampered by climate-dependent model parameterizations. To reduce this dependency, we extended the regional hydrologic modelling framework SIMGRO to host a two-way coupling between the soil moisture model MetaSWAP and the crop growth simulation model WOFOST, accounting for ecohydrologic feedbacks in terms of radiation fraction that reaches the soil, crop coefficient, interception fraction of rainfall, interception storage capacity, and root zone depth. Ex...

  8. Influence of feedbacks from simulated crop growth on integrated regional hydrologic simulations under climate scenarios

    OpenAIRE

    Walsum, P. E. V.

    2011-01-01

    Climate change impact modelling of hydrologic responses is hampered by climate-dependent model parameterizations. Reducing this dependency was one of the goals of extending the regional hydrologic modelling system SIMGRO with a two-way coupling to the crop growth simulation model WOFOST. The coupling includes feedbacks to the hydrologic model in terms of the root zone depth, soil cover, leaf area index, interception storage capacity, crop height and crop factor. For investigating wheth...

  9. Influence of ocean winds on the pelagic ecosystem in upwelling regions

    OpenAIRE

    Rykaczewski, Ryan R.; Checkley, David M.

    2008-01-01

    Upwelling of nutrient-rich, subsurface water sustains high productivity in the ocean's eastern boundary currents. These ecosystems support a rate of fish harvest nearly 100 times the global mean and account for >20% of the world's marine fish catch. Environmental variability is thought to be the major cause of the decadal-scale biomass fluctuations characteristic of fish populations in these regions, but the mechanisms relating atmospheric physics to fish production remain unexplained. Two at...

  10. Postpartum practices of puerperal women and their influencing factors in three regions of Hubei, China

    OpenAIRE

    Chen Banghua; Liu Liegang; Sun Xiufa; Mao Limei; Liu Nian; Ding Qiang

    2006-01-01

    Abstract Background 'Sitting month' is a Chinese tradition for women's postpartum custom. The present study aims to explore the postpartum dietary and health practices of puerperal women and identify their influential factors in three selected regions of Hubei, China. Methods A cross-sectional retrospective study was conducted in the selected urban, suburban and rural areas in the province of Hubei from 1 March to 30 May 2003. A total of 2100 women who had given birth to full-term singleton i...

  11. The factors that Influence Participation and usage Decisions of Destination Management System (DMS) by regional SMTEs

    OpenAIRE

    Hasan, Nazmul; Pasupuleti, Anil Kumar

    2012-01-01

    The tourist industry plays an immense role in the socio-economic development of different regions. Destination Management Systems (DMS) are significant in developing e-tourism. DMS integrate data from Small and Medium-Sized Tourism Enterprises (SMTEs) in order for tourists to find information about e.g. accommodation, restaurants and attractions of a certain location. Although being represented in a DMS has proven to be advantageous, not all SMTEs are participating in such systems. This thesi...

  12. Unusually high soil nitrogen oxide emissions influence air quality in a high-temperature agricultural region

    OpenAIRE

    Oikawa, P. Y.; C. Ge; Wang, J.; Eberwein, J. R.; Liang, L. L.; Allsman, L. A.; Grantz, D.A.; Jenerette, G. D.

    2015-01-01

    Fertilized soils have large potential for production of soil nitrogen oxide (NOx=NO+NO2), however these emissions are difficult to predict in high-temperature environments. Understanding these emissions may improve air quality modelling as NOx contributes to formation of tropospheric ozone (O3), a powerful air pollutant. Here we identify the environmental and management factors that regulate soil NOx emissions in a high-temperature agricultural region of California. We also investigate whethe...

  13. MODELING REGIONAL ALTERNATIVE MANAGEMENT SCENARIOS WITH FUTURE CLIMATIC CHANGE INFLUENCE ACCOUNTING

    OpenAIRE

    Romanenko, Irina

    2008-01-01

    The methodology of construction of the alternative agricultural production scenarios at regional level includes profitability and feasibility analysis based on assessment the effect of global climate change on productivity parameters for the main agricultural crops, cost efficiency of crop growing and cattle breeding. To propose links between economic adaptation to climate change and carbon (organic C) stock management in agricultural ecosystems for use in developing long-term adoption strate...

  14. Influences of Social Networks on Food Choices: A Comparison of Local, Regional, and National Perspectives

    OpenAIRE

    Liang, Chyi-Lyi (Kathleen); Pescatore, Matthew

    2014-01-01

    There has been a growing interest in the U.S. to study local and regional food systems with respect to economic, social, and enterprise development. This paper discusses a series of on-going projects funded by the USDA focusing on two aspects of the relationships between social network and food choices – producers, and interactions between producers and consumers (buyers). Preliminary results showed distribution and opportunities for agricultural producers to exploit and implement new strateg...

  15. Identification and comparative analysis of factors influencing road safety in US regions and in Polish voivodeships

    Directory of Open Access Journals (Sweden)

    Joanna WACHNICKA

    2013-01-01

    Full Text Available Analyses of road safety at national level have been run for many years and large number of publications concerning them appeared so far. How interdisciplinary the issue is, has been shown by literature studies done by the author of the paper. It appears that economists, mathematicians, doctors as well as engineers have studied the issue. It is not an easy one, as results of many analyses lead to conflicting conclusions and often fail to provide straightforward answers to questions asked. The administrative actions taken to improve road safety, uniform for the whole country, frequently fail to give expected results, including Poland’s case. Therefore there is a need to analyse what makes some provinces, and not the others, report improvement in road safety. This paper presents part of the work on author’s doctoral thesis, which analyses how regional characteristics may impact road safety in respective regions. However, during collection of data for the purpose of the doctoral thesis it turned out that many variables mentioned in literature as significant had not been collected on regional level in Europe, including Poland. There are, though, available data on respective American states, so the search for the best describing independent variables started from the analyses of US data. The analyses showed the impact of factors such as annual income per capita, transport activity, density of population, seatbelt rates, road and vehicle density, rate of doctors.

  16. Seed production and recruitment in primary and harvested Nothofagus pumilio forests: Influence of regional climate and years after cuttings

    Directory of Open Access Journals (Sweden)

    Ana D. Torres

    2015-04-01

    Full Text Available Aim of study: Harvesting proposals (e.g. variable retention for Nothofagus pumilio forests are based on canopy opening, to increase recruitment and enhance seedling growth, by modifying light and soil moisture. Seed production and seedling recruitment will define the success of harvesting, where remnant forest structure are the main influence factors, as well as biotic and abiotic factors. The objective was to analyse seed production, seedling recruitment and recruitment efficiency in primary and harvested forests through variable retention along the first 10 years after harvesting, as well as the influence of regional climate. Area of study: The study were conducted in a pure Nothofagus pumilio forest located in central Tierra del Fuego (54°18’ S, 67°49’ W, where harvested stands with variable retention and unmanaged forests were sampled in long-term permanent plots. Material and methods: Data of forest regeneration plots were used (n = 72 (2007 a 2014, and forest structure and seed production (2006 a 2013 were also measured. Regional climate was characterised for these years from satellite images (Sea Surface Temperature and climate re-analysis models (rainfall and temperature of land surface. Main results: Harvesting modified forest structure; however, aggregated retention maintained some characteristics of the primary unmanaged forests. These changes influenced seed production and recruitment. Seed production and recruitment were related to crown cover and the amount of seed production; however, recruitment efficiency was not affected by harvesting. The studied variables significantly changed along the years after harvesting. Seed production and recruitment were also related to regional climate factors, where it was possible to explain their variations through temperature (e.g. summer temperature and rainfall (e.g. winter rainfall for the different retention types in harvested forests and the primary forests. Research highlights

  17. Regional analysis of groundwater nitrate concentrations and trends in Denmark in regard to agricultural influence

    Science.gov (United States)

    Hansen, B.; Dalgaard, T.; Thorling, L.; Sørensen, B.; Erlandsen, M.

    2012-08-01

    The act of balancing between an intensive agriculture with a high potential for nitrate pollution and a drinking water supply almost entirely based on groundwater is a challenge faced by Denmark and similar regions around the globe. Since the 1980s, regulations implemented by Danish farmers have succeeded in optimizing the N (nitrogen) management at farm level. As a result, the upward agricultural N surplus trend has been reversed, and the N surplus has reduced by 30-55% from 1980 to 2007 depending on region. The reduction in the N surplus served to reduce the losses of N from agriculture, with documented positive effects on nature and the environment in Denmark. In groundwater, the upward trend in nitrate concentrations was reversed around 1980, and a larger number of downward nitrate trends were seen in the youngest groundwater compared with the oldest groundwater. However, on average, approximately 48% of the oxic monitored groundwater has nitrate concentrations above the groundwater and drinking water standards of 50 mg l-1. Furthermore, trend analyses show that 33% of all the monitored groundwater has upward nitrate trends, while only 18% of the youngest groundwater has upward nitrate trends according to data sampled from 1988-2009. A regional analysis shows a correlation between a high level of N surplus in agriculture, high concentrations of nitrate in groundwater and the largest number of downward nitrate trends in groundwater in the livestock-dense northern and western parts of Denmark compared with the southeastern regions with lower livestock densities. These results indicate that the livestock farms dominating in northern and western parts of Denmark have achieved the largest reductions in N surpluses. Groundwater recharge age determinations allow comparison of long-term changes in N surplus in agriculture with changes in oxic groundwater quality. The presented data analysis is based on groundwater recharged from 1952-2003, but sampled from 1988

  18. Regional analysis of groundwater nitrate concentrations and trends in Denmark in regard to agricultural influence

    Directory of Open Access Journals (Sweden)

    B. Sørensen

    2012-08-01

    Full Text Available The act of balancing between an intensive agriculture with a high potential for nitrate pollution and a drinking water supply almost entirely based on groundwater is a challenge faced by Denmark and similar regions around the globe. Since the 1980s, regulations implemented by Danish farmers have succeeded in optimizing the N (nitrogen management at farm level. As a result, the upward agricultural N surplus trend has been reversed, and the N surplus has reduced by 30–55% from 1980 to 2007 depending on region. The reduction in the N surplus served to reduce the losses of N from agriculture, with documented positive effects on nature and the environment in Denmark. In groundwater, the upward trend in nitrate concentrations was reversed around 1980, and a larger number of downward nitrate trends were seen in the youngest groundwater compared with the oldest groundwater. However, on average, approximately 48% of the oxic monitored groundwater has nitrate concentrations above the groundwater and drinking water standards of 50 mg l−1. Furthermore, trend analyses show that 33% of all the monitored groundwater has upward nitrate trends, while only 18% of the youngest groundwater has upward nitrate trends according to data sampled from 1988–2009. A regional analysis shows a correlation between a high level of N surplus in agriculture, high concentrations of nitrate in groundwater and the largest number of downward nitrate trends in groundwater in the livestock-dense northern and western parts of Denmark compared with the southeastern regions with lower livestock densities. These results indicate that the livestock farms dominating in northern and western parts of Denmark have achieved the largest reductions in N surpluses. Groundwater recharge age determinations allow comparison of long-term changes in N surplus in agriculture with changes in oxic groundwater quality. The presented data analysis is based on groundwater recharged from 1952

  19. Regional analysis of groundwater nitrate concentrations and trends in Denmark in regard to agricultural influence

    Directory of Open Access Journals (Sweden)

    B. Hansen

    2012-05-01

    Full Text Available The act of balancing between an intensive agriculture with a high potential for nitrate pollution and a~drinking water supply almost entirely based on groundwater is a challenge faced by Denmark and similar regions around the globe. Since the 1980s, regulations implemented by Danish farmers have succeeded in optimizing the N (nitrogen management at farm level. As a result, the upward agricultural N surplus trend has been reversed, and the N surplus has reduced by 30–55 % from 1980 to 2007 depending on region. The reduction in the N surplus served to reduce the losses of N from agriculture, with documented positive effects on nature and the environment in Denmark. In groundwater, the upward trend in nitrate concentration was reversed around 1980, and a larger number of downward nitrate trends were seen in the youngest groundwater compared with the oldest groundwater. However, on average, approximately 48 % of the oxic monitored groundwater has nitrate concentrations above the groundwater and drinking water standards of 50 mg l−1. Furthermore, trend analyses show that 33 % of all the monitored groundwater has upward nitrate trends, while only 18 % of the youngest groundwater has upward nitrate trends according to data sampled from 1988–2009. A regional analysis shows a correlation between a high level of N surplus in agriculture, high concentrations of nitrate in groundwater and the largest number of downward nitrate trends in groundwater in the livestock-dense northern and western parts of Denmark compared with the south-eastern regions with lower livestock densities. These results indicate that the livestock farms dominating in northern and western parts of Denmark have achieved the largest reductions in N surpluses. Groundwater recharge age determinations allow comparison of long-term changes in N surplus in agriculture with changes in oxic groundwater quality. The presented data analysis is based on groundwater recharged from

  20. Factors influencing the prevalence of subclinical mastitis in lactating dromedary camels in Riyadh Region, Saudi Arabia.

    Science.gov (United States)

    Aljumaah, Riyadh S; Almutairi, Faris F; Ayadi, Moez; Alshaikh, Mohammad A; Aljumaah, Ali M; Hussein, Mansour F

    2011-12-01

    The purpose of this study was to determine the prevalence of subclinical mastitis in camels in Riyadh, Saudi Arabia and the factors influencing its incidence. A total of 740 quarter milk samples were collected from 47 camel herds belonging to Majahim, Maghatir, Shu'l, and Sufer breeds. California mastitis test (CMT) was used as a screening test for subclinical mastitis. Samples giving negative or trace CMT scores (0) were assigned to healthy quarters, while those giving positive scores of 1+ to 3+ were assigned to subclinically affected quarters. Logistic regression was used to assess the association of breed, parity, and stage of lactation with the prevalence of subclinical mastitis. Milk fat, protein, lactose, solid nonfat percentages and Na, Ca, and K concentrations were compared in CMT-positive versus healthy quarters. One third (33%) of tested quarters had subclinical mastitis based on CMT. The estimated probability of subclinical mastitis with the combined effects of breed, parity, and stage of lactation ranged from 15.8% to 54.6%. The risk of subclinical mastitis increased significantly with parity and with the early stage of lactation. The Shu'l breed had significantly higher prevalence of subclinical mastitis than other breeds. Significant decreases in protein, lactose, and solid nonfat, Ca and K concentrations and increase in Na concentrations were associated with subclinical mastitis. In conclusion, subclinical mastitis is prevalent in Saudi camels, and its incidence is influenced by breed, parity, and stage of lactation. PMID:21637994

  1. Environmental Determinants Influencing Seasonal Variations of Bird Diversity and Abundance in Wetlands, Northern Region (Ghana

    Directory of Open Access Journals (Sweden)

    Collins Ayine Nsor

    2014-01-01

    Full Text Available The study assessed major environmental determinants influencing bird community in six wetlands over a 2-year period. A combination of visual and bird sounding techniques was used to determine the seasonal variations in bird abundance, while ordination techniques were performed to determine the influence of environmental factors on bird assemblage. A total of 1,169 birds from 25 species and 885 individuals from 23 species were identified in the wet and dry season, respectively. The shallow close marshes supported the greatest number of birds (P<0.05 compared to the riparian wetlands. Bird diversity was significantly higher in the wet season than in the dry season (F=4.101,P<0.05. Cattle egret (Bubulcus ibis and marsh warbler (Acrocephalus palustris were the most abundant. Using the IUCN “Red List” database guide, we noted that 96.2% of birds identified were least concern (LC. The yellow weaver bird (Ploceous megarhrynchus was the only vulnerable species (VU and represented 3.8%. From the three variables tested, bushfire and farming practices were the major threats and cumulatively explained 15.93% (wet season and 14.06% (dry season variations in bird diversity and abundance. These findings will help wetland managers design conservation measures to check current threats on birds from becoming vulnerable in the future.

  2. Regional and local influence of grazing activity on the diversity of a semi-arid dung beetle community

    DEFF Research Database (Denmark)

    Lobo, Jorge M.; Hortal, Joaquín; Cabrero-Sañudo, Francisco J.

    2006-01-01

    municipality were sampled for the local analysis. Spatial and environmental characteristics of sampling sites were also compiled at both scales, including measures of grazing activity (livestock density at regional scale, and two counts of rabbit and sheep dung at local scale). At a regional scale, any...... to the local amount of sheep dung (27% of variance). The amount of dung in a 2-km buffer around the site accounts for 27-32% of variance in abundance and 60-65% of variance in species richness. The presence of the flock with the highest sheep density explains 53% of abundance variability and 73% of...... among nearby sites could be affecting the population dynamics and dispersion of dung beetles within a locality, sites with larger populations, and greater species numbers would not be able to exercise enough influence as to bring about a complete local faunistic homogenization....

  3. Strategic Factors Influencing National and Regional Systems of Innovation: A Case of Weaker NSI with Stronger RSI

    Directory of Open Access Journals (Sweden)

    Pir Roshanuddin Shah Rashdi

    2015-04-01

    Full Text Available The issues of relationship between NSI ((National System of Innovation and RSI (Regional System of Innovation are not well reported with innovation policy research. That is, whether the NSI is the system on top of RSI, or the importance of regions make stronger NSIs. Therefore, it raises concern regarding development of strategic relationship between these two. For this, two cases ? Catalonia (Spain and N Ireland (the UK, have been selected based on theoretical sampling. Key economic indicators have been identified and have been quantitatively analyzed. The evidence suggests that strong NSI has positive influence on RSI. In addition to that, the concentration of knowledge and promotion of institutions may be strategically established and then needed resources may be injected to produce high quality human resources. There is, however, need for more comprehensive studies to be conducted in order to validate the results of this research

  4. Regional seismic observations of the 9 October 2006 underground nuclear explosion in North Korea and the influence of crustal structure on regional phases

    Science.gov (United States)

    Hong, Tae-Kyung; Baag, Chang-Eob; Choi, Hoseon; Sheen, Dong-Hoon

    2008-03-01

    The crustally guided shear wave, Lg, is typically the most prominent phase of a nuclear explosion at regional distance. This Lg phase is analyzed often to discriminate a nuclear explosion from a natural earthquake. In addition, the Lg phase allows us to determine the size of the detonation. A nuclear explosion test in North Korea was conducted on 9 October 2006. The epicenter was located close to the eastern shore of the Korean Peninsula, resulting in raypaths that vary significantly according to the azimuths. In particular, rays radiated in the southern direction experience lateral variation of crustal structures at the continental margin. We examine the influence of raypaths on regional seismic phases by comparing the spectra and waveforms from different raypaths. Three natural earthquakes in North Korea are also examined to determine the raypath effect. We find that the Lg from the nuclear explosion dissipated significantly as result of energy leakage into the mantle resulting from variations in crustal thickness along the portion of the raypath traversing the western tip of the Sea of Japan (East Sea). Some of the leaked energy develops into mantle lid waves (Sn), causing a large energy increase to Sn. A similar feature is observed in the records of natural earthquakes. This feature is confirmed by seismic waveform modeling. The raypath effect also causes underestimation of magnitude. The Lg body wave magnitude, mb(Lg), is estimated to be 3.8-4.2 for records from pure continental paths and 2.6-3.4 for records from paths crossing continental margins. This result illustrates the need to consider raypath effects for the correct estimation of magnitudes of regional events, including a nuclear explosion.

  5. The influence of climate variability on chemical composition of European wines: a regional scale study (Italy and Slovenia)

    Science.gov (United States)

    Barbante, Carlo; Polo, Fabio; Cozzi, Giulio; Ogrinc, Nives; Turetta, Clara

    2016-04-01

    Climate change is having an increasing influence on vine phenology and grape composition, affecting vinifications, wine chemistry and the quality of productions. Wine grape cultivation provides a good test case for measuring indirect impacts mediated by changes in agriculture, because viticulture is sensitive to climate and is concentrated in Mediterranean climate regions that are global biodiversity hotspots. Moreover, on a regional level and on a shorter time scale, the seasonal weather conditions modify the quality of yields determining the final properties of wine. In the present research, we studied wines from Italy and Slovenia with the purpose of differentiating them by the different vintages (from 2009 to 2012), which are supposed to be influenced by temperature and rain during each year's growing season. Specific chemical techniques were used, in particular mass spectrometry (ICP-MS) and isotopic mass spectrometry (IRMS), both of which are usually employed to detect wine adulterations and to establish the geographical provenance of wines. In particular, we investigated the relationship between macro- and micro-elements, Rare Earth Elements and stable isotopes [δ13C, δ18O, (D/H)I, (D/H)II]. The datasets were examined via statistical techniques to show their relation to weather conditions as well as their mutual connection. Italian and Slovenian wines were distinguished, with the exception of few samples, by both TEs and REEs results. This separation, due to different elemental compositions, may be justified as being part of two distinct environmental and geographical belongings (terroir) but also to the processes of wine production, from the harvest to the bottling, which have certainly interfered and characterized the products. In the case of Italian wines the weather conditions were evidenced with an important separation of stable isotopes which they confirmed to be very sensitive Regarding Slovenian wines, the studied regions were characterized of

  6. THE RISK FACTORS INFLUENCING THE EDENTULISM AND PROSTHETIC STATUS OF THE ADULT POPULATION IN DIFFERENT REGIONS OF GEORGIA.

    Science.gov (United States)

    Makhviladze, G; Tsitaishvili, L; Kalandadze, M; Margvelashvili, V

    2016-04-01

    The aim of the present study was to identify the level of edentulism and prosthetic status of the adult population in different regions of Georgia and to assess the influencing risk- factors. Cluster- stratified method was used for sampling. Overall, 2370 adults including 1289 women and 1081 men and four age groups I- (20-34), II-(35-44), III-(45-64), IV- (65-74) in nine regions of Georgia and the capital, Tbilisi, were examined. Statistically reliable data received showed the different extent of teeth loss in various regions of Georgia. ≤10 teeth loss were characteristic for Mtskheta (60.2%) and Samtskhe-Javakheti (50.7%),whilst ≥20 teeth lost were noticed more in Achara(2.9%), Samtskhe-Javakheti(2.6%), Shida Qartli (2,5%). Therefore, prosthetic status was mostly presented with one or more bridges or artificial crowns, removable dentures were seen less. Differences in prosthetic status is generally related to low medical education background in all regions, though lack of money was considered as essential obstacle for dental visit for Mtskheta, Imereti and Samtskhe-Javakheti population. Education and family income dictate attitudes towards prosthetic dental care and choice of crown types. On the other hand, material disparity represents the main obstacle to prosthetic procedures, especially implants. PMID:27249432

  7. Late Holocene anthropogenic and climatic influences on the regional vegetation of Mexico's Cuenca Oriental

    Science.gov (United States)

    Bhattacharya, Tripti; Byrne, Roger

    2016-03-01

    Scholars continue to debate the relative magnitude of pre- and post-Conquest anthropogenic landscape transformation in many regions of Mesoamerica. These debates have important implications for our understanding of the role of anthropogenic practices in the development, or at times degradation, of regional environments. Paleoecological records that provide long-term perspectives on climate change and human land-use patterns are critical to addressing these uncertainties. However, many regions of Mexico including the Cuenca Oriental, a semi-arid basin in the rain shadow of the Sierra Madre Oriental, remain poorly studied. We present a new paleoecological record from sediment cores recovered from Lake Aljojuca, located in the southern part of the basin. Stable isotope analyses of authigenic carbonates provide an independent record of past climate, while pollen and microscopic charcoal provide insights into past vegetation and fire history. The Aljojuca record is one of the only well-dated multi-proxy paleolimnological records from the Cuenca Oriental, and is one of few charcoal studies from highland Mexico. Zea mays pollen and increased fire activity at 2700 calendar years before present (cal yr. BP) suggest Formative period human settlement around the lake. Between 1700 and 800 cal yr BP, a drying climate combined with human uses of fire likely resulted in increases in the extent of xeric scrub vegetation. The Aljojuca record also documents important landscape changes during the historic period (~ 430 cal yr. BP-present) likely related to the introduction of invasive species and agricultural intensification. The Aljojuca record provides a unique perspective on human-environment relationships and highlights differences between landscape transformations in the pre- and post-Conquest periods.

  8. Influence of extended drought on water quality in tropical reservoirs in a semiarid region

    Directory of Open Access Journals (Sweden)

    Gustavo Girão Braga

    2015-03-01

    Full Text Available AimDrought periods often occur in Brazilian semiarid region and are supposed to induce water quality degradation by changes in physical, chemical and biological properties of freshwater ecosystems. Reservoirs in this region are used as drinking-water supplies and are exposed to wide volume fluctuations during drought periods due to lack of precipitation and high evaporation rates. This study aimed to identify patterns on water quality of two reservoirs during a long drought period. It was expected that more arid and shallower conditions would favor algal growth by enhancing nutrient availability, causing a decrease on water quality.MethodsThe study was based on monthly sampling over 20 months (May 2011 to December 2012 at two tropical reservoirs on Brazilian semiarid region. Precipitation and volume data were obtained from environmental agencies. Transparency was measured on field using a Secchi disk and conductivity, nutrients, suspended solids and chlorophyll-a were analyzed on laboratory. Temporal changes in all environmental variables were analyzed in each reservoir using two-way cluster analysis and also principal component analysis (PCA.ResultsThe volume of both reservoirs decreased considerably over the study because of low or shortage of precipitation. It was possible to detect two opposite patterns of chlorophyll-a in each reservoir throughout the drought season: in the first one phytoplankton growth was favored, while in the second one chlorophyll-a decreased by high inorganic turbidity. Both reservoirs tended to increase their turbidity and conductivity during the drought period due to shallow conditions, which probably contributed to sediment resuspension.ConclusionsWater level reduction during the extended drought period, contributed for water quality degradation due to high algal biomass and also high turbidity found during drought period. Local factors, as the nature of suspended solids, play an important role on predicting water

  9. Particle Dark Matter Candidates

    CERN Document Server

    Scopel, Stefano

    2007-01-01

    I give a short overview on some of the favorite particle Cold Dark Matter candidates today, focusing on those having detectable interactions: the axion, the KK-photon in Universal Extra Dimensions, the heavy photon in Little Higgs and the neutralino in Supersymmetry. The neutralino is still the most popular, and today is available in different flavours: SUGRA, nuSUGRA, sub-GUT, Mirage mediation, NMSSM, effective MSSM, scenarios with CP violation. Some of these scenarios are already at the level of present sensitivities for direct DM searches.

  10. Regional analysis of groundwater nitrate concentrations and trends in Denmark in regard to agricultural influence

    OpenAIRE

    Sørensen, B.; L. Thorling; B. Hansen; Dalgaard, T.; M. Erlandsen

    2012-01-01

    The act of balancing between an intensive agriculture with a high potential for nitrate pollution and a drinking water supply almost entirely based on groundwater is a challenge faced by Denmark and similar regions around the globe. Since the 1980s, regulations implemented by Danish farmers have succeeded in optimizing the N (nitrogen) management at farm level. As a result, the upward agricultural N surplus trend has been reversed, and the N surplus has reduced by 30–55% from 1980 to 2007 dep...

  11. Regional analysis of groundwater nitrate concentrations and trends in Denmark in regard to agricultural influence

    OpenAIRE

    B. Hansen; Dalgaard, T.; L. Thorling; Sørensen, B.; M. Erlandsen

    2012-01-01

    The act of balancing between an intensive agriculture with a high potential for nitrate pollution and a~drinking water supply almost entirely based on groundwater is a challenge faced by Denmark and similar regions around the globe. Since the 1980s, regulations implemented by Danish farmers have succeeded in optimizing the N (nitrogen) management at farm level. As a result, the upward agricultural N surplus trend has been reversed, and the N surplus has reduced by 30–55 % from 1980 to 2007...

  12. Influence of nuclear submarine utilization on the radioecological situation on the Russian Far Eastern region

    International Nuclear Information System (INIS)

    The generalized data of the 30-year observations of radioecological situation resulted from the removal from service and utilization of atomic submarines of the Russian Pacific navy are demonstrated. The information about the content of technogenic and natural radioisotopes in air, soil, sea water, bottom sediments, hydrobiontes and other objects is given. It is shown that removal from service and utilization of submarines of the Pacific navy leave inadmissible unaffected of radiation on the population and environment of the Far Eastern region (excepting accident in Chazhma bay, 1985)

  13. Influence of atmospheric nutrients on primary productivity in a coastal upwelling region

    OpenAIRE

    Katherine R.M. Mackey; van Dijken, Gert L.; Mazloom, Simran; Erhardt, Andrea M; Ryan, John; Arrigo, Kevin R; Paytan, Adina

    2010-01-01

    Atmospheric deposition is an important source of nutrients to the coastal and open ocean; however, its role in highly productive upwelling regions like coastal California has not been determined. Approximately 0.1%–0.2% of new production is attributable to atmospheric deposition of nitrogen (N) annually, but if the estimate is expanded to encompass the effects of iron (Fe), aerosols may support 1%–2% of new production on average, and up to 5% on days with high deposition fluxes. Laboratory cu...

  14. Scales and structure of frontal adjustment and freshwater export in a region of freshwater influence

    OpenAIRE

    Hopkins, Joanne; Polton, Jeffrey A.

    2012-01-01

    Sea surface temperature satellite imagery and a regional hydrodynamic model are used to investigate the variability and structure of the Liverpool Bay thermohaline front. A statistically based water mass classification technique is used to locate the front in both data sets. The front moves between 5 and 35 km in response to spring-neap changes in tidal mixing, an adjustment that is much greater than at other shelf-sea fronts. Superimposed on top of this fortnightly cycle are semi-diurnal mov...

  15. Influence of row spacing reduction on maize grain yield in regions with a short summer

    OpenAIRE

    Sangoi Luís; Ender Márcio; Guidolin Altamir Frederico; Almeida Milton Luiz de; Heberle Pedro Canísio

    2001-01-01

    The interest in reducing maize row spacing in the short growing season regions of Brazil is increasing due to potential advantages such as higher radiation use efficiency. This experiment was conducted to evaluate the effect of row spacing reduction on grain yield of different maize cultivars planted at different dates. The trial was conducted in Lages, in the State of Santa Catarina, Brazil, during 1996/97 and 1997/98 growing seasons, in a split-split plot design. Early (October 1st) and nor...

  16. Analysis of a high-resolution regional climate simulation for Alpine temperature. Validation and influence of the NAO

    Energy Technology Data Exchange (ETDEWEB)

    Proemmel, K. [GKSS-Forschungszentrum Geesthacht GmbH (Germany). Inst. fuer Kuestenforschung

    2008-11-06

    To determine whether the increase in resolution of climate models improves the representation of climate is a crucial topic in regional climate modelling. An improvement over coarser-scale models is expected especially in areas with complex orography or along coastlines. However, some studies have shown no clear added value for regional climate models. In this study a high-resolution regional climate model simulation performed with REMO over the period 1958-1998 is analysed for 2m temperature over the orographically complex European Alps and their surroundings called the Greater Alpine Region (GAR). The model setup is in hindcast mode meaning that the simulation is driven with perfect boundary conditions by the ERA40 reanalysis through prescribing the values at the lateral boundaries and spectral nudging of the large-scale wind field inside the model domain. The added value is analysed between the regional climate simulation with a resolution of 1/6 and the driving reanalysis with a resolution of 1.125 . Before analysing the added value both the REMO simulation and the ERA40 reanalysis are validated against different station datasets of monthly and daily mean 2m temperature. The largest dataset is the dense, homogenised and quality controlled HISTALP dataset covering the whole GAR, which gave the opportunity for the validation undertaken in this study. The temporal variability of temperature, as quantified by correlation, is well represented by both REMO and ERA40. However, both show considerable biases. The REMO bias reaches 3 K in summer in regions known to experience a problem with summer drying in a number of regional models. In winter the bias is strongly influenced by the choice of the temperature lapse rate, which is applied to compare grid box and station data at different altitudes, and has the strongest influence on inner Alpine subregions where the altitude differences are largest. By applying a constant lapse rate the REMO bias in winter in the high

  17. The business cycles and the influence of economic confidence indicators in the European region

    Directory of Open Access Journals (Sweden)

    Alexandru Constantinescu

    2012-06-01

    Full Text Available The economic confidence level is expressed by managers that are active in significant economic sectors. The financial markets consider these economic confidence indicators as leading instruments that can point the direction of the real economy. The level of trust in the economy is important because, similar with the stock investors behavior, the private sector managers or the consumers can act and carry a restrictive or a euphoric business policy, actions that could in fact affect the environment in a negative way and could unbalance the economic equilibrium.The role of this study is to propose a methodology of analyzing the influence of the economic confidence indicators over the stock market, an industry that can be overlooked as a transmission environment for the investment sentiment. We plan to study and comment the relation between these indicators, the stock market and future macroeconomic results like the GDP, the industrial production or the unemployment rate.

  18. The Influence of Photolysis Rate Constants in Ozone Production for the Paso del Norte Region

    Science.gov (United States)

    Becerra, Fernando; Fitzgerald, Rosa

    2012-03-01

    In this research work we are focusing on understanding the relationship between photolysis rates and the photochemical ozone changes observed in the Paso del Norte region. The city of El Paso, Texas together with Ciudad Juarez, Mexico, forms the largest contiguous bi-national metropolitan area. This region suffers year-round ozone pollution events, and a better understanding is needed to mitigate them. Previous studies have found that ambient ozone concentrations tend to be higher on weekends rather than on weekdays, this phenomenon being referred to, as the ``weekend effect.'' If the ozone standard is exceeded more frequently on weekends, then this phenomenon must be considered in the design of ozone control strategies. In this work we investigate some of the most representative weekend ozone episodes at El Paso, TX, during the years 2009, 2010 and 2011 using the ozone photolysis rates. In this research the TUV radiative-transfer model is used to calculate the local photolysis rates and a UV MFRSR instrument is used to obtain experimental parameters. Seasonal variations and the weekday-weekend effect is studied. The results of this research will help to understand the underlying behavior of the photolysis rate constants when different atmospheric conditions are present.

  19. Influence of Olive Cultivar on Oil Attributes in the Arid Region of Qom, Iran

    Directory of Open Access Journals (Sweden)

    Maisa Asheri

    2016-03-01

    Full Text Available Olive cultivation has economic and health implications. The quality of harvested oil is affected by the type of cultivar and the climate in which the trees are cultivated. This study was carried out to determine quality indices (peroxide value, K232, and K270, fatty acid composition, and pigment profiles in some cultivars grown in an arid region in central Iran. These are cultivated in completely different climatic conditions than the major olive growing areas of Iran. The results have illustrated that there are significant differences between the cultivars in oil quality, pigments content, and fatty acid composition. Oil quality of all studied cultivars falls within the established ranges for extra virgin olive oil. Oleic acid levels of the ‘Beledy’ and ‘Leccino’ cultivars are below the International Olive Council (IOC established limit. Oils of the ‘Mari’, ‘Koroneiki’, and ‘Mission’ cultivars had the highest monounsaturated fatty acids (MUFA content. However, polyunsaturated fatty acid (PUFA content for Mission oil was considerably higher than ‘Koroneiki’ and ‘Mari’ oils. The ratio of MUFA/PUFA for ‘Mari’ and ‘Koroneiki’ was higher among all the cultivars studied. Furthermore, these two cultivars presented higher oleic/linoleic acid ratio and lower Cox values. Based on our findings, ‘Mari’ and ‘Koroneiki’ are among the best performing cultivars for producing olive oil in intensely hot and arid regions.

  20. [Influence of green roof application on water quantity and quality in urban region].

    Science.gov (United States)

    Wang, Shu-Min; Li, Xing-Yang; Zhang, Jun-Hua; Yu, Hui; Hao, You-Zhi; Yang, Wan-Yi

    2014-07-01

    Green roof is widely used in advanced stormwater management as a major measure now. Taking Huxi catchment in Chongqing University as the study area, the relationships between green roof installation with runoff volume and water quality in urban region were investigated. The results showed that roof greening in the urban region contributed to reducing the runoff volume and pollution load. In addition, the spatial distribution and area of green roof also had effects on the runoff water quality. With the conditions that the roof area was 25% of the total watershed area, rainfall duration was 15 min and rainfall intensity was 14.8 mm x h(-1), the peak runoff and total runoff volume were reduced by 5.3% and 31%, the pollution loads of total suspended solid (TSS), total phosphorus (TP) and total nitrogen (TN) decreased by 40.0%, 31.6% and 29.8%, their peak concentrations decreased by 21.0%, 16.0% and -12.2%, and the EMCs (event mean concentrations) were cut down by 13.1%, 0.9% and -1.7%, respectively, when all impervious roofs were greened in the research area. With the increase of roof greening rate, the reduction rates of TSS and TP concentrations increased, while the reduction rate of TN concentration decreased on the whole. Much more improvement could be obtained with the use of green roofs near the outlet of the watershed. PMID:25345054

  1. Radiographic evaluation of the influence of age and smoking on thoracic and regional pulmonary dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Beeckman, P.; Vanclooster, R.; Demedts, M.; Clarysse, I.

    1983-01-01

    Chest roentgenograms were taken at full inspiration (TLC) and expiration (RV) in healthy, nonsmoking and smoking, young and old subjects in the upright posture. Linear distances (D) were measured in apicodiaphragmatic and transverse thoracic directions and extensions ((Dsub(TLC)-Dsub(RV))/Dsub(TLC) and (Dsub(TLC)-Dsub(RV))/Dsub(RV)) and volumes were calculated. In the apico-diaphragmatic direction a subdivision was made into an apico-fissural (A-F) distance and a fissuro-diaphragmatic (F-D) distance by means of the minor fissure. Overall volumes at TLC were identical in the four groups but differences were present in distances, extensions and volumes above and below the fissure. Aging caused mainly an increase in D(A-F) and a decrease in D(F-D) at TLC as well as at RV, indicating hyperinflation and airtrapping of the upper zone and hypoinflation and flattening of the lower zone. Smoking caused an increase in D(F-D) at RV, indicating airtrapping in the lower zone. In both groups E(F-Dsub(R)) was reduced, but in old subjects this was due to a decrease in regional TLC and in young smokers to an increase in regional RV. In old, smoking subjects a combination of the effects of aging and smoking was present.

  2. Broadband ultrasound attenuation imaging: influence of location of region of measurement.

    Science.gov (United States)

    Damilakis, J; Papadakis, A; Perisinakis, K; Gourtsoyiannis, N

    2001-01-01

    The aim of the study was to investigate the effect of three different regions of interest (ROIs) varying in size and shape on broadband ultrasound attenuation (BUA) measurements of the calcaneus. Two hundred and sixty-five postmenopausal Caucasian women participated in this study. In 43 women osteoporotic fractures were documented on spinal radiographs. Bone mineral density (BMD) measurements of the lumbar spine and the femur were made using dual-energy X-ray absorptiometry. BUA measurements were obtained at a circular ROI automatically determined by the imaging system (ROIc), at a manually traced irregular ROI encompassing the posterior part of the calcaneus (ROIi), and at an anatomical square ROI located in the posterior part of the calcaneus (ROIs). Reproducibility was better in ROIc than in ROIi and ROIs. High correlations were found between BUA measurements with ROIc and ROIs (r = 0.981, P ROIc and ROIi (r = 0.965, P ROIc compared with ROIi and ROIs. No significant difference was found between the areas under the ROC curve at ROIi, ROIc, and ROIs for women with fractures. The results show that superior reproducibility makes ROIc the most appropriate region of BUA measurement in a comparison with ROIi and ROIs. PMID:11471598

  3. Melanoma in the Italian Population and Regional Environmental Influences: A National Retrospective Survey on 2001–2008 Hospitalization Records

    Science.gov (United States)

    Piscitelli, Prisco; Neglia, Cosimo; Falco, Andrea; Rivezzi, Matteo; Agnello, Nadia; Argentiero, Alberto; Chitano, Giovanna; Distante, Chiara; Della Rosa, Giulia; Vinci, Giorgia; De Donno, Antonella; Distante, Alessandro; Romanini, Antonella

    2015-01-01

    Objective: To assess the burden of regional environmental factors influencing the incidence of Melanoma in the Italian population and overcome the problem of partial population coverage by local cancer registries and thematic archives. Methods: We analyzed the Italian national hospitalization records from 2001 to 2008 provided by the Ministry of Health, excluding hospital re-admissions of the same patients, in order to assess the occurrence of Melanoma over a 8-year period. Data were presented by age groups (absolute number of cases from 20 to ≥80 years old) and per Region (rates per 100,000 inhabitants) for each year. Results: The overall number of new hospitalizations due to malignant Melanoma increased by 16.8% from 2001 (n = 4846) to 2008 (n = 5823), with the rate per 100,000 inhabitants passing from 10.5 to almost 12.0 at a national level. The majority of new diagnoses of malignant Melanoma was observed in two age groups: 61–70 years old (from 979 in 2001 up to 1209 in 2008, corresponding to 15.1 and 18.1 new cases per 100,000 inhabitants, respectively) and 71–80 years old (from 954 in 2001 up to 1141 in 2008, corresponding to 19.5 and 21.8 new cases per 100,000 inhabitants, respectively). The number of hospitalizations due to Melanoma increased in all age groups with the only exception of the youngest patients aged 20–30 years old. The highest increases over the 8-year period were observed in people aged ≥81 years old (+34%), 61–70 years old (+20%) and surprisingly in the age group 31–40 years old (+17%). Southern Regions showed lower hospitalization rates compared to Northern Italy and Region Lazio. The highest increases between 2001 and 2008 were observed in Trentino/Alto Adige, Friuli Venezia Giulia, Valla d’Aosta and Veneto Region. Conclusions: Hospitalizations due to malignant Melanoma in Italy seem to be influenced by environmental or population-related factors showing a decreasing incidence rate from the Northern to Southern Regions

  4. Numerical groundwater flow calculations at the Finnsjoen study site - The influence of the regional gradient

    International Nuclear Information System (INIS)

    The present report describes the modelling efforts of the groundwater flow situation at the Finnsjoen site in northern Uppland, approximately 140 km north of Stockholm. The study forms part of the SKB 91 performance assessment project, and aims at describing the model sensitivity to changes in the prevailing regional gradient, as well as the local, with regard to both direction and magnitude. Particular emphasis has been put into the evaluation of travel times and travel paths form a potential repository, and also on flux values at repository level. The analyses were based on the finite element technique and made use of the NAMMU-code for stationary calculations in three dimensions. The fracture zones within the modelled area were modelled implicitly with an averaging technique. (au)

  5. Influence of stellar component on the conditions for thermal instability in the Galactic center Minispiral region

    Science.gov (United States)

    Kunneriath, D.; Rozanska, A.; Czerny, B.; Adhikari, T.; Karas, V.

    2015-07-01

    Previously we demonstrated that collisions between clumps of gas in the Circum-Nuclear Disc can reduce their angular momentum and set some of the clumps on a plunging trajectory towards the supermassive black hole. If the central luminosity is determined by the gas accretion mechanism, then there exists a certain range of accretion rate and efficiency that allow the thermal instability to sustain the mass inflow through the two-temperature medium. Here we explore the stellar component of the nuclear star cluster which acts as an additional source of heating and contributes an additional energy input into the gaseous environment in the Galactic center Minispiral region. Under these conditions we discuss the values of relevant parameters that can support or suppress the thermal instability.

  6. Newly identified YSO candidates towards the LDN 1188

    CERN Document Server

    Marton, Gábor; Kiss, Csaba; Smidla, József

    2013-01-01

    We present an analysis of Young Stellar Object (YSO) candidates towards the LDN 1188 molecular cloud. The YSO candidates were selected from the WISE all-sky catalogue, based on a statistical method. We found 601 candidates in the region, and classified them as Class I, Flat and Class II YSOs. Groups were identified and described with the Minimal Spanning Tree (MST) method. Previously identified molecular cores show evidence of ongoing star formation at different stages throughout the cloud complex.

  7. Modeling the influence of land surface flux on the regional climate of the Tibetan Plateau

    Science.gov (United States)

    Ma, Weiqiang; Ma, Yaoming

    2016-07-01

    Land surface heat fluxes over the heterogeneous landscape of the Tibetan Plateau can serve as boundary conditions for modeling the regional climate and the Asian monsoon system. The Weather Research and Forecasting (WRF) atmospheric modeling system has enabled us to model the land surface heat flux through sensitivity experiments that utilize in situ observation data and the regional land-atmosphere exchanges of water and heat fluxes that are foundational to understanding the water and energy cycles present during the Asian monsoon period. A series of sensitivity experiments based on the WRF model and field observations has been proposed and tested for deriving the land surface heat fluxes (surface net radiation flux, soil heat flux, sensible heat flux, and latent heat flux) over a heterogeneous land surface. The sensitivity experiments were simulated over the field area of the Coordinated Enhanced Observing Period Asia-Australia Monsoon Project on the Tibetan Plateau (CEOP-CAMP/Tibet), located on the northern Tibetan Plateau of China. A WRF modeling period from July to August 2007 was selected for the summer monsoon conditions. To validate the modeling results, the ground-measured or calculated variables (e.g., net radiation flux, soil heat flux, sensible heat flux, and latent heat flux) were compared to the simulated values. The modeling results show that the derived model land surface heat fluxes are in agreement with the land surface observations over the study area in summer. Therefore, the WRF model sensitivity experiments were successful in simulating the land surface heat fluxes over the study area.

  8. Regional-scale influences on urban air quality : a field study in Phoenix, Arizona.

    Energy Technology Data Exchange (ETDEWEB)

    Gaffney, J. S.

    1998-10-12

    Regional air quality can play an important role in determining whether urban ozone or PM-2.5 standards are exceeded. Background levels of nitrogen oxide species (NO{sub x}) and their interactions with natural organics can generate secondary aerosol products via formation of nitric acid and its subsequent reaction with ammonia to form ammonium nitrate. Natural organics and reactive anthropogenic organic compounds, particularly aromatic species and monoterpenes, can also lead to the formation of secondary organic aerosols, contributing to the formation of PM-2.5. Long-range transport and chemical transformation of hydrocarbons and NO{sub x} via both photochemical reactions and nighttime chemistry can yield significant regional levels of ozone and other oxidants, such as peroxyacyl nitrates (R-C=O-O-O-NO{sub 2}; PANs). The PANs are key species in determining the apparent age of an air parcel (Gaffney et al., 1989, 1993, 1997). The most common member of the family is peroxyacetyl nitrate (R=CH3-; PAN), which typically accounts for more than 85% of the PANs found in an urban or rural site. The PANs are in equilibrium with NO{sub 2}. Peroxyacyl radicals (R-C=O-O-O) are typically produced by the photooxidation reactions of organics, particularly those of aldehyde oxidation products with OH radical during the daytime (photochemically active) periods. Proposed mechanisms for nighttime formation of PANs (Gaffney et al., 1989) include abstraction reactions of nitrate radical (NO{sub 3}) and the initiation of OH chemistry by olefin-ozone reactions.

  9. Influence of vortical flow structures on the glottal jet location in the supraglottal region.

    Science.gov (United States)

    Kniesburges, Stefan; Hesselmann, Christina; Becker, Stefan; Schlücker, Eberhard; Döllinger, Michael

    2013-09-01

    Within the fully coupled multiphysics phonation process, the fluid flow plays an important role for sound production. This study addresses phenomena in the flow downstream of synthetic self-oscillating vocal folds. An experimental setup consisting of devices for producing and conditioning the flow including the main test channel was applied. The supraglottal channel was designed to prevent an acoustic coupling to the vocal folds. Hence, the oscillations were aerodynamically driven. The cross-section of the supraglottal channel was systematically varied by increasing the distance between the lateral channel walls. The vocal folds consisted of silicone rubber of homogenous material distribution generating self-sustained oscillations. The airflow was visualized in the immediate supraglottal region using a laser-sheet technique and a digital high-speed camera. Furthermore, the flow was studied by measuring the static pressure distributions on both lateral supraglottal channel walls. The results clearly showed different flow characteristics depending on the supraglottal configuration. In all cases with supraglottal channel, the jet was located asymmetrical and bent in medial-lateral direction. Furthermore, the side to which the jet was deflected changed in between the consecutive cycles showing a bifurcational behavior. Previously, this phenomenon was explained by the Coanda effect. However, the present data suggest that the deflection of the jet was mainly caused by large air vortices in the supraglottal channel produced by the flow field of previous oscillations. In contrast, for the case without supraglottal channel, the air jet was found totally symmetrical stabilized by the constant pressure in the ambient region. The emitted sound signal showed additional subharmonic tonal peaks for the asymmetric flow cases, which are characteristics for diplophonia. PMID:23911009

  10. Influence of tides and gravity waves on layering processes in the polar summer mesopause region

    Directory of Open Access Journals (Sweden)

    P. Hoffmann

    2008-12-01

    Full Text Available Polar Mesosphere Summer Echoes (PMSE have been studied at Andenes (69° N, 16° E, Norway, using VHF radar observations since 1994. One remarkable feature of these observations is the fact that {during 50% of the time,} the radar echoes occur in the form of two or more distinct layers. In the case of multiple PMSE layers, statistical analysis shows that the lower layer occurs at a mean height of ~83.4 km, which is almost identical to the mean height of noctilucent clouds (NLC derived from observation with the ALOMAR Rayleigh/Mie/Raman lidar at the same site. To investigate the layering processes microphysical model simulations under the influence of tidal and gravity waves were performed. In the presence of long period gravity waves, these model investigations predict an enhanced formation of multiple PMSE layer structures, where the lower layer is a consequence of the occurrence of the largest particles at the bottom of the ice cloud. This explains the coincidence of the lowermost PMSE layers and NLC. During periods with enhanced amplitudes of the semidiurnal tide, the observed NLC and PMSE show pronounced tidal structures comparable to the results of corresponding microphysical simulations. At periods with short period gravity waves there is a tendency for a decreasing occurrence of NLC and for variable weak PMSE structures.

  11. Influence of tree water potential in inducing flowering in Rhododendron arboreum in the central Himalayan region

    Directory of Open Access Journals (Sweden)

    Tewari A

    2016-05-01

    Full Text Available Rise in temperature has been reported as the principal cause of variation in flowering phenology in several tree species around the globe. In this study, we hypothesized that not only temperature but also rainfall periodicity, soil moisture and the related changes of twig water potential (ψ in winter and early spring are important drivers of bud expansion and flowering in Rhododendron arboreum in central Himalayas. To this purpose, phenological and physiological variables (flowering time, flower bud size and twig water potential were monitored over two years in a wild population of R. arboreum (Uttarakhand, India and related with environmental variables (rainfall, soil moisture and temperature. Results showed that a rise in twig ψ to -0.7MPa, one week after moderate winter precipitation resulted in flower bud enlargement. In both years flowering was triggered after twig ψ reached the threshold of -0.5 Mpa, though the starting date differed between years. Floral bud size was correlated positively with twig ψ (r = 0.43, df =162, p < 0.001 and soil moisture (r = 0.61, df = 71, p < 0.001, while temperature did not influence flower bud size, soil moisture and twig ψ. Flower bud size increment was related with increase in twig ψ and soil moisture. Based on our results, we concluded that water availability plays an important role in inducing flowering in R. arboreum.

  12. Modeling the influence of various water stressors on regional water supply infrastructures and their embodied energy

    Science.gov (United States)

    Mo, Weiwei; Zhang, Qiong

    2016-06-01

    Water supply consumes a substantial amount of energy directly and indirectly. This study aims to provide an enhanced understanding of the influence of water stressors on the embodied energy of water supply (EEWS). To achieve this goal, the EEWS in 75 North Carolina counties was estimated through an economic input-output based hybrid life cycle assessment. Ten water stressor indicators related to population, economic development, climate, water source, and land use were obtained for the 75 counties. A multivariate analysis was performed to understand the correlations between water stressor indicators and the EEWS. A regression analysis was then conducted to identify the statistically significant indicators in describing the EEWS. It was found that the total amount of water supply energy varies significantly among selected counties. Water delivery presents the highest energy use and water storage presents the least. The total embodied energy was found to be highly correlated with total population. The regression analysis shows that the total embodied energy can be best described by total population and temperature indicators with a relatively high R square value of 0.69.

  13. INFLUENCE OF ELECTROACUPUNCTURE ON THE ULTRASTRUCTURE OF CA3 REGION OF THE HIPPOCAMPUS IN VD RATS

    Institute of Scientific and Technical Information of China (English)

    YAN Bing; XU Neng-gui; HE Li-lei; TANG Chun-zhi; SHAO Ying

    2006-01-01

    Objective: To observe the effect of electroacupuncture (EA) on learning and memory abilities and ultrastructure of synapses in CA3 region of the hippocampus in vascular dementia (VD) rats. Methods: A total of 32 SD rats were randomized into control (sham-operation, n = 7), model (n = 7), EA (n = 9) and medication (n=9) groups. VD model was established by occlusion of the bilateral vertebral arteries (electrocoagulation) and bilateral common carotid arteries (occlusion for 5 min and reperfusion for 10 min, repeated the procedure for 3 times to induce global ischemia). EA (150 Hz, 1 mA) was applied to "Baihui"(百会GV 20), "Geshu"(膈俞 BL 17), "Pishu"(脾俞 BL 20) and "Shenshu"(肾俞 BL 23) for 20 min, once daily and continuously for 15 days. In medication group, the rats were fed with Nimotong (12 mg/kg), once daily and continuously for 15 days. Morris water maze method was used to test the animals' learning and memory abilities (latencies to find the hidden platform determined by place navigation trials, and latencies to cross on the location of the removed platform determined by spatial probe trials) after the treatment. Ultrastructural changes (numerical density, NA,surface density, Sv and volume density, Vv) of Gray type 1 synapses in CA3 region of the hippocampus were observed by using transmission electronic microscope and automatic image analysis system. Results: 1 ) Place navigation test showed that in comparison with control group, the average escape latency of VD group was significantly longer (P<0.01), while in comparison with VD group, the latencies of both EA and medication groups decreased significantly ( P<0.01 ). No significant difference was found between EA and medication groups in the escape latency (P>0.05). 2) Spatial probe-test displayed that in comparison with control group, the times which the animals crossed the target platform in VD group decreased significantly (P<0.01), while compared with VD group, those of both EA and

  14. Influence of nanomirelal phases on development processes of oil reservoirs in Volga-Ural region

    Science.gov (United States)

    Izotov, Victor; Sitdikova, Lyalya

    2010-05-01

    The optimisation of oil-field development by enhancing oil recovery is the most important target in further improvement of oil production processes. The resulting economic benefits often exceed those from discoveries of new fields, especially in hard-to-reach regions. Despite the wide use of enhanced oil recovery methods, their efficiency is in many cases not as high as expected. For instance, in terrigenous reservoirs of the Volga-Ural region oil recovery rarely exceeds 0.4, and in carbonate reservoirs with the complex structure, variability and high oil viscosity it can be as low as 0.15-0.20. In natural bitumen fields, the recovery factor is even lower. Analysis of the conducted EOR optimisation operations indicates that EOR methods mainly aim to change the hydrodynamic conditions in the reservoir under development or the physicochemical properties of oil, - for instance, to decrease its viscosity or to change its lyophilic behaviour. The impact of EOR methods on the reservoir's mineral component remains largely unstudied. It is generally believed that the mineral component of the reservoir, its matrix, is inert and remains unaffected by EOR methods. However, the analysis of oil-field development processes and the available studies allow the conclusion that natural hydrocarbon reservoirs are sensitive to any impact on both the near-wellbore zone and the whole reservoir. The authors' research in the reservoir's mineral phase dynamics has permitted the conclusion that the reservoir's fluid phases (including hydrocarbons) and the reservoir itself form a lithogeochemical system that remains in unstable equilibrium. Any external impact, such as the reservoir penetration or the use of EOR methods, disturbs this equilibrium and changes the filtration characteristics of the reservoir, the fluid chemistry and the reaction of the reservoir's mineral component to the impact. In order to characterise the processes in the reservoir in the course of its development, the

  15. Influence of feedbacks from simulated crop growth on integrated regional hydrologic simulations under climate scenarios

    Science.gov (United States)

    van Walsum, P. E. V.

    2011-11-01

    Climate change impact modelling of hydrologic responses is hampered by climate-dependent model parameterizations. Reducing this dependency was one of the goals of extending the regional hydrologic modelling system SIMGRO with a two-way coupling to the crop growth simulation model WOFOST. The coupling includes feedbacks to the hydrologic model in terms of the root zone depth, soil cover, leaf area index, interception storage capacity, crop height and crop factor. For investigating whether such feedbacks lead to significantly different simulation results, two versions of the model coupling were set up for a test region: one with exogenous vegetation parameters, the "static" model, and one with endogenous simulation of the crop growth, the "dynamic" model WOFOST. The used parameterization methods of the static/dynamic vegetation models ensure that for the current climate the simulated long-term average of the actual evapotranspiration is the same for both models. Simulations were made for two climate scenarios. Owing to the higher temperatures in combination with a higher CO2-concentration of the atmosphere, a forward time shift of the crop development is simulated in the dynamic model; the used arable land crop, potatoes, also shows a shortening of the growing season. For this crop, a significant reduction of the potential transpiration is simulated compared to the static model, in the example by 15% in a warm, dry year. In consequence, the simulated crop water stress (the unit minus the relative transpiration) is lower when the dynamic model is used; also the simulated increase of crop water stress due to climate change is lower; in the example, the simulated increase is 15 percentage points less (of 55) than when a static model is used. The static/dynamic models also simulate different absolute values of the transpiration. The difference is most pronounced for potatoes at locations with ample moisture supply; this supply can either come from storage release of a

  16. Influence of feedbacks from simulated crop growth on integrated regional hydrologic simulations under climate scenarios

    Directory of Open Access Journals (Sweden)

    P. E. V. van Walsum

    2011-11-01

    Full Text Available Climate change impact modelling of hydrologic responses is hampered by climate-dependent model parameterizations. Reducing this dependency was one of the goals of extending the regional hydrologic modelling system SIMGRO with a two-way coupling to the crop growth simulation model WOFOST. The coupling includes feedbacks to the hydrologic model in terms of the root zone depth, soil cover, leaf area index, interception storage capacity, crop height and crop factor. For investigating whether such feedbacks lead to significantly different simulation results, two versions of the model coupling were set up for a test region: one with exogenous vegetation parameters, the "static" model, and one with endogenous simulation of the crop growth, the "dynamic" model WOFOST. The used parameterization methods of the static/dynamic vegetation models ensure that for the current climate the simulated long-term average of the actual evapotranspiration is the same for both models. Simulations were made for two climate scenarios. Owing to the higher temperatures in combination with a higher CO2-concentration of the atmosphere, a forward time shift of the crop development is simulated in the dynamic model; the used arable land crop, potatoes, also shows a shortening of the growing season. For this crop, a significant reduction of the potential transpiration is simulated compared to the static model, in the example by 15% in a warm, dry year. In consequence, the simulated crop water stress (the unit minus the relative transpiration is lower when the dynamic model is used; also the simulated increase of crop water stress due to climate change is lower; in the example, the simulated increase is 15 percentage points less (of 55 than when a static model is used. The static/dynamic models also simulate different absolute values of the transpiration. The difference is most pronounced for potatoes at locations with ample moisture supply; this supply can either come

  17. Factors Influencing the Improved Academic Success in Literacy at the Knowledge Is Power Program (KIPP) Schools in the Delta Region According to Adult Perceptions

    Science.gov (United States)

    Brown, Kimberly J.; Holt, Carleton R.

    2014-01-01

    This qualitative case study explored factors that have influenced literacy success of Knowledge is Power Program (KIPP) students in the low-income, poverty stricken Delta Region of Arkansas. The study examined progress made since implementation of the KIPP Program and the influence the program had made upon student achievement in literacy at the…

  18. Influence of Large-scale Climate Modes on Atmospheric Rivers That Drive Regional Precipitation Extremes

    Science.gov (United States)

    Guan, B.; Molotch, N. P.; Waliser, D. E.; Fetzer, E. J.; Neiman, P. J.

    2014-12-01

    Atmospheric rivers (ARs) are narrow channels of enhanced meridional water vapor transport between the tropics and extratropics that drive precipitation extremes in the west coast areas of North America and other continents. The influence of large-scale climate modes on ARs is analyzed in terms of modulation on AR frequency and AR-related snow water equivalent (SWE) anomalies, with a focus on understanding the causes of the anomalously snowy winter season of 2010/2011 in California's Sierra Nevada. Mean SWE on 1 April 2011 was ~70% above normal averaged over 100 snow sensors. AR occurrence was anomalously high during the season, with 20 AR dates from November to March and 14 dates in the month of December 2010, compared to the mean occurrence of 9 dates per season. Most of the season's ARs occurred during negative phases of the Arctic Oscillation (AO) and the Pacific-North American (PNA) teleconnection pattern. Analysis of all winter ARs in California during water years 1998-2011 indicates more ARs occur during the negative phase of AO and PNA, with the increase between positive and negative phases being ~90% for AO, and ~50% for PNA. The circulation pattern associated with concurrent negative phases of AO and PNA, characterized by cyclonic anomalies centered northwest of California, provides a favorable dynamical condition for ARs. The analysis suggests that the massive Sierra Nevada snowpack during the 2010/2011 winter season is primarily related to anomalously high frequency of ARs favored by the joint phasing of -AO and -PNA, and that a secondary contribution is from increased snow accumulation during these ARs favored by colder air temperatures associated with -AO, -PNA and La Niña. The results have implications for subseasonal-to-seasonal predictability of AR activities and related weather and water extremes.

  19. Seasonal and regional influences on the fatty acid composition of cow's milk fat from Asturias. Spain

    Directory of Open Access Journals (Sweden)

    Bada, Juan Carlos

    2004-06-01

    Full Text Available The effect of seasonal and geographical influences on the fatty acid compositions of cow's milk fat from Asturias (northern Spain was studied. The majority of the fatty acids analysed presented differences (p Se estudia el efecto de la influencia estacional y de la situación geográfica en la composición de ácidos grasos de la grasa de leche de vaca de Asturias (Norte de España. La mayoría de los ácidos grasos analizados presentaron diferencias (p<0.05 debido a factores estacionales, solo tres ácidos grasos (iC14; iC16 and C18:1 no presentaron diferencias significativas (p<0.05 ni debido a factores estacionales ni geográficos. Los ácidos grasos de cadena corta, media y larga presentaron diferencias debidas al factor estacional y sólo los ácidos grasos de larga cadena presentaron diferencias con el área geográfica. Sin embargo, sólo los ácidos grasos insaturados mostraron diferencias (p<0.05 debidas a la estación del año y al área geográfica. El coeficiente de correlación obtenido mostró una fuerte relación lineal entre los pares de ácidos grasos C4-C12, C6-C10 y C10-C12.

  20. Infrared study of new star cluster candidates associated to dusty globules

    Science.gov (United States)

    Soto King, P.; Barbá, R.; Roman-Lopes, A.; Jaque, M.; Firpo, V.; Nilo, J. L.; Soto, M.; Minniti, D.

    2014-10-01

    We present results from a study of a sample of small star clusters associated to dusty globules and bright-rimmed clouds that have been observed under ESO/Chile public infrared survey Vista Variables in the Vía Láctea (VVV). In this short communication, we analyse the near-infrared properties of a set of four small clusters candidates associated to dark clouds. This sample of clusters associated to dusty globules are selected from the new VVV stellar cluster candidates developed by members of La Serena VVV Group (Barbá et al. 2014). Firstly, we are producing color-color and color-magnitude diagrams for both, cluster candidates and surrounding areas for comparison through PSF photometry. The cluster positions are determined from the morphology on the images and also from the comparison of the observed luminosity function for the cluster candidates and the surrounding star fields. Now, we are working in the procedures to establish the full sample of clusters to be analyzed and methods for subtraction of the star field contamination. These clusters associated to dusty globules are simple laboratories to study the star formation relatively free of the influence of large star-forming regions and populous clusters, and they will be compared with those clusters associated to bright-rimmed globules, which are influenced by the energetic action of nearby O and B massive stars.

  1. Minding the gap: Frequency of indels in mtDNA control region sequence data and influence on population genetic analyses

    Science.gov (United States)

    Pearce, J.M.

    2006-01-01

    Insertions and deletions (indels) result in sequences of various lengths when homologous gene regions are compared among individuals or species. Although indels are typically phylogenetically informative, occurrence and incorporation of these characters as gaps in intraspecific population genetic data sets are rarely discussed. Moreover, the impact of gaps on estimates of fixation indices, such as FST, has not been reviewed. Here, I summarize the occurrence and population genetic signal of indels among 60 published studies that involved alignments of multiple sequences from the mitochondrial DNA (mtDNA) control region of vertebrate taxa. Among 30 studies observing indels, an average of 12% of both variable and parsimony-informative sites were composed of these sites. There was no consistent trend between levels of population differentiation and the number of gap characters in a data block. Across all studies, the average influence on estimates of ??ST was small, explaining only an additional 1.8% of among population variance (range 0.0-8.0%). Studies most likely to observe an increase in ??ST with the inclusion of gap characters were those with control region DNA appears small, dependent upon total number of variable sites in the data block, and related to species-specific characteristics and the spatial distribution of mtDNA lineages that contain indels. ?? 2006 Blackwell Publishing Ltd.

  2. Regional Variations of Public Perception on Contaminated Industrial Sites in China and Its Influencing Factors.

    Science.gov (United States)

    Li, Xiaonuo; Jiao, Wentao; Xiao, Rongbo; Chen, Weiping; Bai, Yanying

    2016-04-01

    Public involvement is critical in sustainable contaminated site management. It is important for China to improve public knowledge and participation, foster dialogue between urban managers and laypeople, and accelerate the remediation and redevelopment processes in contaminated site management. In this study, we collected 1812 questionnaires from nine cities around China through face-to-face interviews and statistically analyzed the perception of residents concerning contaminated sites. The results show that respondents' concern about soil pollution was lower than for other environmental issues and their knowledge of soil contamination was limited. The risks posed by contaminated industrial sites were well recognized by respondents, but they were unsatisfied with the performance of local agencies regarding information disclosure, publicity and education and public participation. Respondents believed that local governments and polluters should take the primary responsibility for contaminated site remediation. Most of them were unwilling to pay for contaminated site remediation and preferred recreational or public service redevelopment. Moreover, our research indicated that public perception varied among different cities. This variation was mainly determined by implementations of policy instruments and additionally affected by remediation technology, pollutant type, regional policy response and living distance. PMID:27070632

  3. Dissociation of dorsal hippocampal regional activation under the influence of stress in freely behaving rats

    Directory of Open Access Journals (Sweden)

    Johannes Passecker

    2011-10-01

    Full Text Available Stress has deleterious effects on brain, body and behaviour in humans and animals alike. The present work investigated how 30-minute acute photic stress exposure impacts on spatial information processing in the main subregions of the dorsal hippocampal formation (CA1, CA3 and Dentate Gyrus, a brain structure prominently implicated in memory and spatial representation. Recordings were performed from spatially tuned hippocampal and dentate gyrus cells in rats while animals foraged in a square arena for food. The stress procedure induced a decrease in firing frequencies in CA1 and CA3 place cells while sparing locational characteristics. In contrast to the CA1-CA3 network, acute stress failed to induce major changes in the DG neuronal population. These data demonstrate a clear dissociation of the effects of stress on the main hippocampal sub-regions. Our findings further support the notion of decreased hippocampal excitability arising from stress in areas CA1 and CA3, but not in dentate gyrus.

  4. The influence of regional hydrology on nesting behavior and nest fate of the American alligator

    Science.gov (United States)

    Ugarte, Cristina A.; Bass, Oron L.; Nuttle, William; Mazzotti, Frank J.; Rice, Kenneth G.; Fujisaki, Ikuko; Whelan, Kevin R.T.

    2013-01-01

    Hydrologic conditions are critical to the nesting behavior and reproductive success of crocodilians. In South Florida, USA, growing human settlement has led to extensive surface water management and modification of historical water flows in the wetlands, which have affected regional nesting of the American alligator (Alligator mississippiensis). Although both natural and anthropogenic factors are considered to determine hydrologic conditions, the aspects of hydrological patterns that affect alligator nest effort, flooding (partial and complete), and failure (no hatchling) are unclear. We deconstructed annual hydrological patterns using harmonic models that estimated hydrological matrices including mean, amplitude, timing of peak, and periodicity of surface water depth and discharge and examined their effects on alligator nesting using survey data from Shark Slough, Everglades National Park, from 1985 to 2005. Nest effort increased in years with higher mean and lesser periodicity of water depth. A greater proportion of nests were flooded and failed when peak discharge occurred earlier in the year. Also, nest flooding rates were greater in years with greater periodicity of water depth, and nest failure rate was greater when mean discharge was higher. This study guides future water management decisions to mitigate negative impacts on reproduction of alligators and provides wildlife managers with a tool for assessing and modifying annual water management plans to conserve crocodilians and other wetland species.

  5. Regional Variations of Public Perception on Contaminated Industrial Sites in China and Its Influencing Factors

    Directory of Open Access Journals (Sweden)

    Xiaonuo Li

    2016-04-01

    Full Text Available Public involvement is critical in sustainable contaminated site management. It is important for China to improve public knowledge and participation, foster dialogue between urban managers and laypeople, and accelerate the remediation and redevelopment processes in contaminated site management. In this study, we collected 1812 questionnaires from nine cities around China through face-to-face interviews and statistically analyzed the perception of residents concerning contaminated sites. The results show that respondents’ concern about soil pollution was lower than for other environmental issues and their knowledge of soil contamination was limited. The risks posed by contaminated industrial sites were well recognized by respondents, but they were unsatisfied with the performance of local agencies regarding information disclosure, publicity and education and public participation. Respondents believed that local governments and polluters should take the primary responsibility for contaminated site remediation. Most of them were unwilling to pay for contaminated site remediation and preferred recreational or public service redevelopment. Moreover, our research indicated that public perception varied among different cities. This variation was mainly determined by implementations of policy instruments and additionally affected by remediation technology, pollutant type, regional policy response and living distance.

  6. Solar influence on the MLT region: NOx production during solar proton events and ion chemistry

    International Nuclear Information System (INIS)

    The chemistry in the mesosphere/lower thermosphere (MLT) region is always driven by forcing from solar radiation and energetic particles. The resulting ionisation, dissociation and excitation of the constituents lead to production of reactive species such as NOx(N,NO,NO2) and HOx(H,OH,HO2), both directly from dissociation as well as indirectly from subsequent ion chemistry reactions. While the ions and HOx are short lived and disappear when the forcing is over, NOx is transported downwards and contributes to ozone depletion. Approximately, the production rate of NOx is proportional to the ionisation rate, while the loss primarily results from the photolytic dissociation of NO. High ionisation rates usually occur during Solar Proton Events (SPEs) and geomagnetic storms (aurora and radiation belt particles) where energetic electrons and protons penetrate the earth's atmosphere in polar latitudes. The production rates of NOx are modeled using an ion chemistry model and their dependency on various parameters such as altitude and ionisation rate is discussed.

  7. Regional Variations of Public Perception on Contaminated Industrial Sites in China and Its Influencing Factors

    Science.gov (United States)

    Li, Xiaonuo; Jiao, Wentao; Xiao, Rongbo; Chen, Weiping; Bai, Yanying

    2016-01-01

    Public involvement is critical in sustainable contaminated site management. It is important for China to improve public knowledge and participation, foster dialogue between urban managers and laypeople, and accelerate the remediation and redevelopment processes in contaminated site management. In this study, we collected 1812 questionnaires from nine cities around China through face-to-face interviews and statistically analyzed the perception of residents concerning contaminated sites. The results show that respondents’ concern about soil pollution was lower than for other environmental issues and their knowledge of soil contamination was limited. The risks posed by contaminated industrial sites were well recognized by respondents, but they were unsatisfied with the performance of local agencies regarding information disclosure, publicity and education and public participation. Respondents believed that local governments and polluters should take the primary responsibility for contaminated site remediation. Most of them were unwilling to pay for contaminated site remediation and preferred recreational or public service redevelopment. Moreover, our research indicated that public perception varied among different cities. This variation was mainly determined by implementations of policy instruments and additionally affected by remediation technology, pollutant type, regional policy response and living distance. PMID:27070632

  8. Influence of the language dominant hemisphere on the activation region of the cerebral cortex during mastication

    International Nuclear Information System (INIS)

    We used functional magnetic resonance imaging (fMRI) to examine the relationship of the activation region of the cerebral cortex during mastication with the language dominant hemisphere. Twelve healthy subjects were asked to chew a special gum 50 times on each side of the mouth, the gum changed color, becoming a deeper red, as it was chewed. The depth of red of the chewed gum was used to ascertain the habitual masticatory side. Measurements were also performed on a conventional whole body 1.5 T clinical scanner using a single shot, multislice echo-planar imaging sequence. The subjects were asked to masticate first on the right side, and then on the left side. As well, they were instructed to do a shiritori test, which is a word game. Computer analysis of the fMRI was done using statistical parametric mapping (SPM) 99 software (p<0.001, paired t-test). We found that the sensorimotor cortex activated by masticatory movements always contains language dominant hemisphere. (author)

  9. The macroeconomic analysis of public goods and their influence in the region of Czech Republic

    Directory of Open Access Journals (Sweden)

    Richard POSPÍŠIL

    2016-04-01

    Full Text Available In the region of Czech Republic, the provision of public goods is one of the State’s most important activities with society-wide impacts. Therefore, the debate on the structure and scope of public budgets is legitimate and ongoing on a society-wide scale. Mainstream fiscal theory considers public goods to be one of the failures of market equilibrium, classifying them as being close to positive externalities. In this case, the activity of the State brings benefits to other entities that are not involved in this activity and do not even directly pay for it. The main characteristics of these goods include irreducibility of their amount in society, non-excludability and non-rivalry. There are a number of goods between purely private and purely public goods which, to varying extents, exhibit both elements. Today, the majority of goods provided by the public sector are of such a nature; as a result, the form of allocation and the subsequent redistribution of resources are crucial when analysing public goods. The present paper analyses public goods in the Czech Republic from an economic and legal perspective using Cost-Benefit Analysis, including their efficiency and society-wide benefits.

  10. Modelling the influence of peri-urban trees in the air quality of Madrid region (Spain)

    International Nuclear Information System (INIS)

    Tropospheric ozone (O3) is considered one of the most important air pollutants affecting human health. The role of peri-urban vegetation in modifying O3 concentrations has been analyzed in the Madrid region (Spain) using the V200603par-rc1 version of the CHIMERE air quality model. The 3.7 version of the MM5 meteorological model was used to provide meteorological input data to the CHIMERE. The emissions were derived from the EMEP database for 2003. Land use data and the stomatal conductance model included in CHIMERE were modified according to the latest information available for the study area. Two cases were considered for the period April-September 2003: (1) actual land use and (2) a fictitious scenario where El Pardo peri-urban forest was converted to bare-soil. The results show that El Pardo forest constitutes a sink of O3 since removing this green area increased O3 levels over the modified area and over down-wind surrounding areas. - Highlights: → Role of peri-urban vegetation in modifying O3 pollution in Madrid (Spain). → The CHIMERE air quality model was adapted to Mediterranean conditions. → Preserving the peri-urban forest lowers O3 concentrations over the surrounding areas. → Evergreen broadleaf and deciduous forests removed more atmospheric O3 than conifers. - Peri-urban forests contribute to ameliorate ozone air pollution.

  11. Geologic and anthropogenic factors influencing karst development in the Frederick region of Maryland

    Science.gov (United States)

    Brezinski, D.K.

    2007-01-01

    Karst features pervade the outcrop belts of Triassic, Ordovician, and Cambrian rocks in the Frederick Valley region of Maryland's western Piedmont. Detailed stratigraphic analysis and geologic and karst mapping demonstrate that individual stratigraphic units have differing susceptibilities of karst feature creation. Although the Triassic Leesburg Member of the Bull Run Formation and Rocky Springs Station Member of the Cambrian Frederick Formation have many surface depressions within their outcrop belts, the Lime Kiln Member of the Frederick Formation and the Ceresville, Fountain Rock, and Woodsboro members of the Ordovician Grove Formation have the greatest potential for development of catastrophic collapse sinkholes. Although these four members have the highest relative susceptibility, human activity can increase the potential for sinkhole activation in all units. Rerouting of surface drainage patterns, unlined drainage, and storm-water management areas and removal of significant overburden deposits significantly increase sinkhole development, but mainly, these units are inherently more susceptible to begin with. Copyright ?? 2007. The American Association of Petroleum Geologists/Division of Environmental Geosciences. All rights reserved.

  12. The influence of climate change to European Lakes, with a special emphasis in the Balkan Region

    International Nuclear Information System (INIS)

    There are almost one and half million lakes in Europe, if small water bodies with an area down to 0.001 km2 are included. The total area of lakes is over 200.000 km2, in addition the man-made reservoirs cover almost 100.000 km2. The largest lakes are located in the zone extending from southwestern Sweden through Finland to Russia, but there are many important lakes also in central and southern Europe. The Balkan countries have altogether about ten thousand lakes with a total area of over 4000 km2 and total volume of almost loo km3. Over half of the total volume is in Lake Ohrid, which ranks the seventh in Europe both as to the volume and as to the maximum depth. However, there are around thirty lakes in Europe with their surface area larger than that of Lake Ohrid. In addition to the lakes, the Balkan countries also have thousands of reservoirs with a total water storage capacity of over 50 km3. The response of European lakes to climate change can be discussed by dividing the lakes into five categories: 1) deep temperate lakes, 2) shallow temperate lakes, 3) mountain lakes, 4) boreal lakes and 5) arctic lakes. The lakes in the Balkan region fall belong into the first three categories. Most of the deep temperate lakes are warm monomictic; convective overturn occurs in winter or early spring. The future climate change may suppress this overturn, giving these lakes the classification of oligomictic. This implies the enhancement of anoxic bottom conditions and an increased risk of eutrophication. The oxygen conditions can also be expected to deteriorate due to increased bacterial activity in deep waters and superficial bottom sediment. In shallow temperate lakes, higher water temperatures in the future will induce intensified primary production and bacterial decomposition. The probability of harmful extreme events, e.g. the mass production of algae, will increase. The impacts may extend to fishing and recreational use. In lakes with relatively long water retention

  13. INFLUENCE OF THE ENVIRONMENT ON THE CONTENT OF ARSENIC IN CULTIVATED SOILS IN ZGORZELEC-BOGATYNIA REGION

    Directory of Open Access Journals (Sweden)

    Ewa Kucharczak-Moryl

    2014-10-01

    Full Text Available The study was conducted in the area of influence of Mine and Power Plant “Turów” which, through the emission of gaseous and particulate pollutants contribute to soil contamination, among other things by arsenic. The aim of this study was to determine the total content of this metal in samples of anable soils collected in the area of the impact of the above-mentioned emitters. At the same time their grain-size distribution and their physico-chemical properties, as pH and percentage of organic matter were determined. Soils collected from a depth of 0.0 to 0.3 m below ground surface, and from 0.3 to 0.6 m b.g.s. came from the area of direct impact of the mine and power plant (area of Bogatynia and the region of Zgorzelec ,located out of the direct impact of emitters. Total arsenic content was determined by ICP- AES using a plasma spectrometer Varian Liberty Series II. All soil samples, independently of the place of origin, showed acid pH, and organic matter content in both research areas was higher at a depth of 0.0 to 0.3 m. In accordance with the classification of PTG 2008, soils from the area of Zgorzelec were classified as very light, light and medium (loose sand, loamy sand, sandy loam and light loam, with a high content of sand fraction it was also found. The soils of Bogatynia region were classified as medium and heavy silty (loamy silt and clayey silt, with a high content of silt fraction . Increased levels of arsenic in cultivated soils in the area of influence of the Mine and Power Plant, on the one hand they are connected with its anthropogenic its release during the combustion of coal, and on the other hand it is the influence of physico-chemical properties of soils. It is the reason of increased accumulation of this metal, mostly at a depth of 0.3 to 0.6 m. Significant, 3 times, higher level of this metal was showed in the area of direct impact of Mine and Power Plant “Turów”, compared with the area of Zgorzelec, apart from

  14. Optimization of 2.5 μm VECSEL: influence of the QW active region

    Science.gov (United States)

    Holl, P.; Rattunde, M.; Adler, S.; Bächle, A.; Diwo-Emmer, E.; Aidam, R.; Manz, C.; Köhler, K.; Wagner, J.

    2016-03-01

    Using the (AlGaIn)(AsSb) material system, VECSELs covering the 2 - 3 μm wavelength range can be realized. The best laser performance of GaSb-based VECSELs was achieved so far at emission wavelengths around 2.0 μm with a slope efficiency of more than 30 %, a low threshold pump power density of 1.1 kW/cm2 at 20°C heatsink temperature and concomitant a high output power exceeding 7 W in CW operation (depending on the mounting technology). These parameters were degrading significantly for longer wavelength devices emitting around 2.5 μm and 2.8 μm. But for applications like the generation of MWIR light (3-8 μm) by pumping ZGP-OPOs, high-power VECSELs around 2.5 μm are required to suppress absorption losses, while for medical laser treatment, high-power operation near the water absorption peak at around 2.9 μm is desirable. We will present results of our ongoing research strand for further optimization of the semiconductor heterostructure design of >= 2.5 μm emitting GaSb-based VECSELs. By using a low quantum deficit design (i.e. optical pumping at around 1.5 μm) in combination with highly strained QWs (compressive strain 2.1 %) we were able to realize a 2.5 μm emitting VECSEL with a slope efficiency above 30 %, corresponding to an external quantum efficiency exceeding 50 %, and a low threshold pump power density of 0.8 kW/cm2. These values are as good as those for the best performing 2.0 μm VECSELs. With a frontside SiC heatspreader and operated in a standard linear cavity, over 7 W of CW output power were achieved for this 2.5 μm emitting VECSEL structure when operated at 20°C. Furthermore, we will compare laser structures with different emission wavelengths and discuss the role of the QW strain, band-offset and active region composition on laser performance.

  15. Influence of Pig Slurry on Microbial and Biochemical Characteristics of Soil in Albacete Region, SE Spain

    Science.gov (United States)

    Halil Yanardaǧ, Ibrahim

    2013-04-01

    Soil quality is very important in terms of agricultural sustainability, ecosystem and terrestrial carbon (C) cycle. In turn, soil microbial and biochemical characteristics are indicative of nutrient cycling and soil organic matter dynamics. We investigated the effects of the pig slurries (raw pig slurry (RPS) and treated pig slurry (TPS) from liquid and solid feeding diets) on microbial and biochemical characteristics of soil under barley cropping system. Application doses of slurries are identified with legal doses of Castilla La Mancha Region, which is 210 kg N ha-1 year-1. Microbial biomass C, soluble C, black C and three soil enzymes (β-Glucosidase, β-galactosidase and Arylesterase enzymes) are studied to determine effect slurry on soil biochemical characteristics, which are very important in terms of C cycle in soil. Black carbon content and β-Glucosidase enzyme activities are increased with all pig slurry applications from liquid and traditional feeding diet, as well as microbial biomass and organic carbon content and β-galactosidase enzyme activities are increased with slurry from liquid feeding diet doses. However, pig slurry application from liquid feeding diet doses have increased yield, quality, length and total biomass content of barley. Bioavailable metal contents are increased with all slurry application and with using high doses of slurry can be caused soil pollution. Pig slurries from liquid feeding diet had positive impacts on microbial and biochemical characteristics in terms of soil quality in comparison to the different feeding diets. PS addition to soil had a very significant stimulating effect on the enzyme activities, microbial biomass, soluble and black C compared with different kind of PS and control plots on Mediterranean soil in barley monoculture. This effect may originate from the organic C, N, P and S compounds added with PS. The highest enzyme activity and microbial biomass were observed on the soil samples from the RPS treatment

  16. Combining evidence of selection with association analysis increases power to detect regions influencing complex traits in dairy cattle

    Directory of Open Access Journals (Sweden)

    Schwarzenbacher Hermann

    2012-01-01

    Full Text Available Abstract Background Hitchhiking mapping and association studies are two popular approaches to map genotypes to phenotypes. In this study we combine both approaches to complement their specific strengths and weaknesses, resulting in a method with higher statistical power and fewer false positive signals. We applied our approach to dairy cattle as they underwent extremely successful selection for milk production traits and since an excellent phenotypic record is available. We performed whole genome association tests with a new mixed model approach to account for stratification, which we validated via Monte Carlo simulations. Selection signatures were inferred with the integrated haplotype score and a locus specific permutation based integrated haplotype score that works with a folded frequency spectrum and provides a formal test of signifance to identify selection signatures. Results About 1,600 out of 34,851 SNPs showed signatures of selection and the locus specific permutation based integrated haplotype score showed overall good accordance with the whole genome association study. Each approach provides distinct information about the genomic regions that influence complex traits. Combining whole genome association with hitchhiking mapping yielded two significant loci for the trait protein yield. These regions agree well with previous results from other selection signature scans and whole genome association studies in cattle. Conclusion We show that the combination of whole genome association and selection signature mapping based on the same SNPs increases the power to detect loci influencing complex traits. The locus specific permutation based integrated haplotype score provides a formal test of significance in selection signature mapping. Importantly it does not rely on knowledge of ancestral and derived allele states.

  17. Influences of large- and regional-scale climate on fish recruitment in the Skagerrak-Kattegat over the last century

    Science.gov (United States)

    Linderholm, Hans W.; Cardinale, Massimiliano; Bartolino, Valerio; Chen, Deliang; Ou, Tinghai; Svedäng, Henrik

    2014-06-01

    Dynamics of commercial fish stocks are generally associated with fishing pressure and climate variability. Due to short time series, past studies of the relationships between fish stock dynamics and climate have mainly been restricted to the last few decades. Here we analyzed a century-long time series of plaice, cod and haddock from the Skagerrak-Kattegat, to assess the long-term influence of climate on recruitment. Recruitment success (RS) was compared against sea-surface temperature (SST) and atmospheric circulation indices on large (North Atlantic) and regional (Skagerrak-Kattegat) scales. Our results show that the influence of climate on RS was more pronounced on longer, than on shorter timescales. Over the century-long period, a shift from low to high climate sensitivity was seen from the early to the late part for plaice and cod, while the opposite was found for haddock. This shift suggests that the increasing fishing pressure and the climate change in the Skagerrak-Kattegat have resulted in an increased sensitivity of RS to climate for plaice and cod. The diminishing of climate sensitivity in haddock RS, on the other hand, may be linked to the early twentieth century collapse of the stock in the region. While no long-term relationship between RS and the Atlantic Multidecadal Oscillation (AMO) could be found, large RS fluctuations during the positive phase of the AMO (1935-1960), relative to the cold phases, suggests a changed pattern in recruitment during warm periods. On the other hand, this could be due to the increased fishing pressure in the area. Thus, reported correlations between climate and fish may be caused by strong trends in climate in the late-twentieth century, and coincident reduction in fish stocks caused by intense fishing, rather than a stable relationship between climate and fish recruitment per se.

  18. Distribution patterns and possible influencing factors of As speciation in ornithogenic sediments from the Ross Sea region, East Antarctica.

    Science.gov (United States)

    Lou, Chuangneng; Liu, Xiaodong; Liu, Wenqi; Wu, Libin; Nie, Yaguang; Emslie, Steven D

    2016-05-15

    Ornithogenic sediments are rich in toxic As (arsenic) compounds, posing a potential threat to local ecosystems. Here we analyzed the distribution of As speciation in three ornithogenic sediment profiles (MB6, BI and CC) collected from the Ross Sea region, East Antarctica. The distributions of total As and total P (phosphorus) concentrations were highly consistent in all three profiles, indicating that guano input is a major factor controlling total As distribution in the ornithogenic sediments. The As found in MB6 and CC is principally As(V) (arsenate), in BI As(III) (arsenite) predominates, but the As in fresh guano is largely composed of DMA (dimethylarsinate). The significant difference of As species between fresh guano and ornithogenic sediment samples may be related to diagenetic processes after deposition by seabirds. Based on analysis of the sedimentary environment in the studied sediments, we found that the redox conditions have an obvious influence on the As speciation distribution. Moreover, the distributions of As(III) and chlorophyll a in the MB6 and BI profiles are highly consistent, demonstrating that aquatic algae abundance may also influence the distribution patterns of As speciation in the ornithogenic sediments. PMID:26930318

  19. An empirical research on the influencing factors of regional CO2 emissions: Evidence from Beijing city, China

    International Nuclear Information System (INIS)

    Highlights: ► We adapt STIRPAT model to regional context and conduct PLS regress analysis. ► Energy technology related patent is innovatively used to measure technical factors. ► Urbanization level has the greatest interpretative ability for CO2 emissions. ► We do not find evidence of Environmental Kuznets Curve in Beijing. ► Beijing should focus more on tertiary industry and residential energy consumption. -- Abstract: In order to further study the realization of carbon intensity target, find the key influencing factors of CO2 emissions, and explore the path of developing low-carbon economy, this paper empirically studied the influences of urbanization level, economic level, industry proportion, tertiary industry proportion, energy intensity and R and D output on CO2 emissions in Beijing using improved STIRPAT (stochastic impacts by regression on population, affluence and technology) model. The model is examined using partial least square regression. Results show that urbanization level, economic level and industry proportion positively influence the CO2 emissions, while tertiary industry proportion, energy intensity and R and D output negatively do. Urbanization level is the main driving factor of CO2 emissions, and tertiary industry proportion is the main inhibiting factor. In addition, along with the growth of per capita GDP, the increase of CO2 emissions does not follow the Environmental Kuznets Curve model. Based on these empirical findings and the specific circumstances of Beijing, we provide some policy recommendations on how to reduce carbon intensity. Beijing should pay more attention to tertiary industry and residential energy consumption for carbon emission reduction. It is necessary to establish a comprehensive evaluation index of social development. Investing more capital on carbon emission reduction science and technology, and promoting R and D output is also an efficient way to reduce CO2 emissions.

  20. THE INFLUENCE OF FIRMS STRUCTURAL CHARACTERISTICS ON THE DEGREE OF AGGLOMERATION ECONOMIES ENJOYED AMONGST FIRMS IN THE LAGOS REGION, NIGERIA

    Directory of Open Access Journals (Sweden)

    FAGBOHUNKA Adejompo

    2015-12-01

    Full Text Available Agglomeration economies is a potent tool in socio-economic revamping, rejuvenation and sustenance of regions, this is as a result of the impulse it transmitted through the multiplier effect it is capable of generated. Therefore, this paper underscores the influence of firms structural characteristics on the degree of agglomeration economies enjoyed amongst firms, using the Lagos region as a case study. The first stage in the collection of primary data involves the reconnaissance survey, thereafter one hundred and three questionnaire were administered in twelve industrial estates; one questionnaire in each of the firm. The paper reveals the following structural characteristics as germane to industrial enterprise; age of firms, areal plant size (m², capacity utilization (in percentage, and Labour size and firms investment. The paper has also found out those agglomeration economies enjoyed ranges from transportation, labour, power supply, to joint water supply. The Roy’s Largest Root test employed to test for the significance of the canonical correlations at 0.05 significant levels shows the calculated F-value 3.5247 and the tabulated F-value 2.90. This suggests that the degree of agglomeration economies enjoyed by firms is significantly explained by the size and structural characteristics of the firms. The paper therefore recommends more and active government participation in the industrial scene, given the necessary support for the expansion of firm’s structural characteristics which will lead to increase agglomeration economies enjoyed by these firms.

  1. A spatially explicit multi-isotope approach to map influence regions of plant-plant interactions after exotic plant invasion

    Science.gov (United States)

    Hellmann, Christine; Oldeland, Jens; Werner, Christiane

    2015-04-01

    Exotic plant invasions impose profound alterations to native ecosystems, including changes of water, carbon and nutrient cycles. However, explicitly quantifying these impacts remains a challenge. Stable isotopes, by providing natural tracers of biogeochemical processes, can help to identify and measure such alterations in space and time. Recently, δ15N isoscapes, i.e. spatially continuous representations of isotopic values, derived from native plant foliage, enabled to accurately trace nitrogen introduced by the N2-fixing invasive Acacia longifolia into a native Portuguese dune system. It could be shown that the area of the system which was altered by the invasive species exceeded the area which was covered by the invader by far. But still, definition of clear regions of influence is to some extent ambiguous. Here, we present an approach using multiple isoscapes derived from measured foliar δ13C and δ15N values of a native, non-fixing species, Corema album. By clustering isotopic information, we obtained an objective classification of the study area. Properties and spatial position of clusters could be interpreted to distinguish areas that were or were not influenced by A. longifolia. Spatial clusters at locations where A. longifolia was present had δ15N values that were enriched, i.e. close to the atmospheric signal of 0 o compared to the depleted values of the uninvaded system (ca. -11 o). Furthermore, C. album individuals in these clusters were characterized by higher foliar N content and enriched δ13C. These results indicate that the N2-fixing A. longifolia added nitrogen to the system which originated from the atmosphere and was used by the native C. album, inducing functional changes, i.e. an increase in WUE. Additionally, clusters were identified that were presumably determined by inherent properties of the native system. Thus, combining isotope ecology with geostatistical methods is a promising approach for mapping regions of influence in multi

  2. Influences of climate change on California and Nevada regions revealed by a high-resolution dynamical downscaling study

    Energy Technology Data Exchange (ETDEWEB)

    Pan, Lin-Lin [University of California, Department of Land, Air and Water Resources, Davis, CA (United States); National Center for Atmospheric Research, Research Applications Laboratory, Boulder, CO (United States); Chen, Shu-Hua; Hart, Quinn; Zhang, Ming-Hua [University of California, Department of Land, Air and Water Resources, Davis, CA (United States); Cayan, Dan [University of California, Scripps Institution of Oceanography, San Diego, CA (United States); Lin, Mei-Ying [Taiwan Typhoon and Flood Research Institute, Taichung (China); Liu, Yubao [National Center for Atmospheric Research, Research Applications Laboratory, Boulder, CO (United States); Wang, Jianzhong [California Department of Water Resources, Sacramento, CA (United States)

    2011-11-15

    In this study, the influence of climate change to California and Nevada regions was investigated through high-resolution (4-km grid spacing) dynamical downscaling using the WRF (Weather Research and Forecasting) model. The dynamical downscaling was performed to both the GFS (Global forecast model) reanalysis (called GFS-WRF runs) from 2000-2006 and PCM (Parallel Climate Model) simulations (called PCM-WRF runs) from 1997-2006 and 2047-2056. The downscaling results were first validated by comparing current model outputs with the observational analysis PRISM (Parameter-elevation Regressions on Independent Slopes Model) dataset. In general, the dominant features from GFS-WRF runs and PCM-WRF runs were consistent with each other, as well as with PRISM results. The influences of climate change on the California and Nevada regions can be inferred from the model future runs. The averaged temperature showed a positive trend in the future, as in other studies. The temperature increases by around 1-2 C under the assumption of business as usual over 50 years. This leads to an upward shifting of the freezing level (the contour line of 0 C temperature) and more rain instead of snow in winter (December, January, and February). More hot days (>32.2 C or 90 F) and extreme hot days (>37.8 C or 100 F) are predicted in the Sacramento Valley and the southern parts of California and Nevada during summer (June, July, and August). More precipitation is predicted in northern California but not in southern California. Rainfall frequency slightly increases in the coast regions, but not in the inland area. No obvious trend of the surface wind was indicated. The probability distribution functions (PDF) of daily temperature, wind and precipitation for California and Nevada showed no significant change in shape in either winter or summer. The spatial distributions of precipitation frequency from GFS-WRF and PCM-WRF were highly correlated (r = 0.83). However, overall positive shifts were seen in

  3. Towards integrating the influence of erosion on within field variability of C input, stock and stability in regional SOC estimates

    Science.gov (United States)

    Meersmans, J.; Quine, T. A.

    2013-12-01

    Improved management of the SOC pool has become an important issue for policymakers in order to maintain soil quality and reduce climate change. Hence, there exists an increased interest in accurate mapping of SOC at the regional scale. Most of these studies are limited to topsoil, consider only factors present at the landscape scale (e.g. climate, land use, soil type) and are at rather coarse resolution. Consequently, the variability of SOC at smaller scales in complex terrain driven by soil erosion, such as stable subsoil carbon buried in depositional areas, is still rather understudied and is not (well) presented in these estimates. Nevertheless, incorporating this smaller level of spatial detail will most probably have a major influence on regional SOC stock dynamics' calculations and mapping. In the present study we aim to unravel the variation in quantity and quality of SOC depth distributions along typical hillslope transects under cropland (Devon, UK) and relate these to soil redistribution rates and variations in C input, i.e. below and above ground biomass productivity. The radionuclide isotope Caesium-137 (137Cs) was used as proxy for erosion. The results show contrasting vertical patterns in SOC stock and stability depending on the rate and type of erosion. For example, sites characterized by deposition due to water erosion (i.e. foot slope) have much higher SOC values near the surface, but show a fast decline with depth, while sites characterized by deposition due to tillage erosion (i.e. most concave position) have moderated SOC surface values that stay constant until a depth of 50 cm, but with increasing stability with depth. The above ground biomass productivity is most linked to water erosion, since we found lowest above ground biomass at the steepest slope position and the highest above ground biomass at the foot slopes. Furthermore, root biomass in the most concave section is significantly higher as compared to any other topo-position. The present

  4. THE INFLUENCE OF MACROECONOMIC FACTORS ON ARRIVALS IN RURAL TOURISTIC PENSIONS IN CRISANA REGION FROM ROMANIA - PART 1

    Directory of Open Access Journals (Sweden)

    Barbu Ionel

    2015-07-01

    Full Text Available In this study we present an econometric analysis of the number of arrivals in rural touristic pensions based on several indicators that we believe may affect in a positive or negative fluctuations of tourists. The analysis we perform for the period January 2006 - December 2013 with a quarterly frequency. We ordered and monthly values of most of the indicators selected, but we tried from start a reduction effect of seasonality.Given the emerging crisis in the second half of 2008, we expect basically after 2008 appear a decrease arrivals in rural touristic pensions, and after 2010, the year a slight recovery from the crisis appear improved this activity.For analysis we selected eight indicators: The average national unemployment; The average national inflation; The volume index of turnover for services provided to the population (hotels and restaurants; The volume index of turnover for services provided to the population (tourist assistance activities; Net use index of accommodation in rural guesthouses nationwide; Net use index of accommodation places in the region Crişana; Average gross salary at national level; GDP. So, in this study we have tried to analyze the influence of macroeconomic factors on rural touristic pensions arrivals in Romania Crisana region. This analysis will help owners of pensions in the management.In this paper we try to find the difficulties, limitations of rural tourism development in Crisana region from perspective of local government. In this paper we try to show as well the main factors of the emergence and development of rural tourism in order to establish priorities in the joint action of local people, entrepreneurs, tourists and local and national administrations. In many countries, the tourism industry fall within government priority. Tourism has been identified as one of the primary industries with potential to support local communities in developing economic diversity.

  5. Influences of Holocene sea level, regional tectonics, and fluvial, gravity and slope currents induced sedimentation on the regional geomorphology of the continental slope off northwestern India

    Digital Repository Service at National Institute of Oceanography (India)

    Chauhan, O.S.; Almeida, F.

    Regional geomorphology derived from echosounding and bathymetric data (lines of a total of 12,000 km), depth to basement, regional deep seated tectonic features, surficial sediment distribution and Holocene sedimentation rates of the continental...

  6. Overcoming trends in irregularly spaced locations by regional polish - exemplified by estimation of the range of influence between Salmonella Dublin-seropositive cattle herds

    DEFF Research Database (Denmark)

    Ersbøll, Annette Kjær; Ersbøll, Bjarne Kjær

    2010-01-01

    -resolution map of the spatial locations is often used where data locations are assigned to the nearest lattice node followed by median polish. In this study regional polish was developed. The inverse distance weighted median was calculated based on observations from locations in the neighbourhood of the actual...... observation. The regional polish residual is obtained as the difference between the observed value and the weighted median. The regional polish procedure was applied to Salmonella Dublin data showing strong regional trends. Estimation of the range of influence between cattle herds with positive S. Dublin herd...

  7. Teasing Apart Regional Climate and Meltwater Influences on Florida Straits Sea Surface Temperature and Salinity over the past 40 kyr

    Science.gov (United States)

    Schmidt, M. W.; Lynch-Stieglitz, J.

    2008-12-01

    Recent reconstructions of North Atlantic salinity variability over the last glacial cycle show that abrupt climate events are linked to major reorganizations in the low-latitude hydrologic cycle, affecting large-scale changes in evaporation minus precipitation (E-P) patterns. Although there is general agreement that the Intertropical Convergence Zone (ITCZ) migrates southward during cold stadials, it remains unclear how this shift affects the net E-P budget in the North Atlantic. In order to reconstruct a high resolution record of past sea surface temperature (SST) and salinity (SSS) in the Florida Straits across abrupt climate events of the last 40 kyr, we combine Mg/Ca paleothermometry and δ18O measurements in shells from the surface-dwelling foraminifera Globigerinoides ruber in cores KNR166-2-JPC29 (24°17'N, 83°16'W; 648 m depth; 8-20 cm/kyr sed. rate) and JPC26 (24°19.61'N, 83°15.14'W; 546 m depth; 18-240 cm/kyr sed. rate) and calculate δ18OSEAWATER (δ18OSW) variability. Removal of the δ18OSW signal due to continental ice volume variation results in the ice volume-free (IVF) δ18OSW record (a proxy for SSS variability). Although most waters flowing through the Florida Straits today originate in the tropical western Atlantic, major meltwater discharges from the Mississippi River across the last deglacial period also influenced SST and SSS in the Florida Straits. To constrain periods of increased meltwater discharge, we measured Ba/Ca ratios in G. ruber from select intervals. Because riverine waters have a much higher dissolved Ba+2 concentration relative to seawater, foraminifera Ba/Ca ratios can be used as an additional proxy to constrain periods of increase riverine discharge. Initial results suggest the hydrographic history of the Florida Straits is influenced by both meltwater discharge and regional climate variability linked to the high-latitude North Atlantic. Both the IVF- δ18OSW and Ba/Ca records reveal a prolonged period from 16.0-13.0 kyr

  8. Regional differences in the factors that influence China’s energy-related carbon emissions, and potential mitigation strategies

    International Nuclear Information System (INIS)

    Energy-related carbon emissions in China have increased significantly. To mitigate these emissions, it is necessary to estimate the trends (increase or decrease) and the magnitudes of the influences (tons of carbon emitted) as a result of four causal factors that affect emissions: GDP, economic structure, energy intensity, and fuel mix. To do so, we have divided the study period into three intervals (from 1995 to 2009) based on China’s three most-recent 5-year plans. We then divided China’s 30 provinces into four categories based on the individual and net effects of these factors on carbon emissions. On this basis, we discuss potential strategies for reducing China’s carbon emissions. Increasing GDP caused the largest increase in carbon emissions, whereas decreasing energy intensity significantly decreased emissions. Changes in the economic structure increased emissions, with the economic structure becoming more carbon-intensive; efforts to optimize the fuel mix slightly decreased emissions during the first and third periods, but increased emissions during the second period. Our analysis also revealed differences between provinces and regions, allowing local managers to focus on the most important problems for their area. To reduce future energy-related carbon emissions, China’s economic structure, energy intensity, and fuel mix must all be improved. - Highlights: ► We developed a model to decompose carbon emissions into four causal factors. ► We estimated the directions and magnitudes of the influences of four factors. ► China’s 30 provinces were classified based on the effects of these factors. ► We discussed potential strategies for mitigating China’s carbon emissions.

  9. The assessment of selected factors influencing intent to get pregnant in the Greater Poland Region

    Directory of Open Access Journals (Sweden)

    Małgorzata Wojciechowska

    2014-06-01

    Full Text Available introduction and objective. Nowadays, people decide to have a baby by first analysing their financial situation. Tradition is no longer a factor which determines the decision whether or not to have a baby. A prognosis of the Polish Central Statistical Office (GUS shows that the population of Poland will fall from 38 to 36 million by 2035. The aim of this study is to assess the procreation behaviour of women in Greater Poland Region. materials and methods. For the research purpose, 3,120 women of reproductive age were examined by using an author designed questionnaire and a synthetic Family Financial Standard Index. results: 74.6% of the respondents lived in an urban area, 25.4% of women come from a rural area. 49% of examined women did not want to have a bigger family, 45% would like to have another child. Analysis of the reasons why women did not want to have another baby revealed that predominance of the financial factor – 67%, living conditions – 18.4% and health– 13.2%. Only 11.9% of the women declared their high financial status, 4.8% of families received family allowance from the government; 88.4% of the examined families did not receive any social benefits. Bad housing situation was declared by 5% of the respondents, 26.7% of the interviewees lived with family members, i.e. parents or grandparents. Analysis of the data concerning religious bonds showed that 67.6% of women declared their indifference to religion. conclusions. The economic factor was an important reason limiting procreation. The bad situation on the real estate market combined with an insufficient range of social welfare led to a decrease in the birth-rate in the Greater Poland region. The impact of religion on family planning was less important. The influence of the analysed socio-economic factors on family planning was similar in rural and urban areas.

  10. The influence of social activity on regional cerebral blood flow and mental function in the normal aged volunteers

    International Nuclear Information System (INIS)

    The infuence of social activity on regional cerebral blood flow (rCBF) and mental function was studied by Xe133 inhalation method in normal aged volunteers. Subjects: The first group consisted of 33 aged volunteers living in nursing home and exposed to little social stimuli. There were 15 males (mean age of 77 years) and 18 females (77 years). The second group consisted of 49 aged community volunteers who were confirmed socially active. There were 25 males (76 years) and 24 females (72 years). All subjects were healthy persons without a past hitory of cerebral diseases and lung diseases. There were no difference in blood pressure and hematocrit between the two groups. Method: The rCBF was measured by 16-ch-Novo-cerebrograph. Verbal intelligence was evaluated by the Hasegawa Simple Intelligence Scale for Aged. Performance intelligence was evaluated with the Kohs' Block Design Test. Results: 1) The mean rCBF in group I showed significantly lower value than that of group II, especially in the frontotemporal region. The performance intelligence was decreased in group I. However, there were no significant difference in the verbal intelligence between the two groups. 2) The aging effect on rCBF and intelligences was more prominent in group II. 3) In males, hemispheric rCBF of group I decreased bilaterally associated with the decrease of both intelligences. While the left hemispheric rCBF in females was relatively preserved as well as the preservation of verbal intelligence. These results indicate that the social environmental factors may have significant influence to aging of the brain especially in the males. (author)

  11. Factors Influencing Anti-Malarial Prophylaxis and Iron Supplementation Non-Compliance among Pregnant Women in Simiyu Region, Tanzania

    Science.gov (United States)

    Sambili, Benatus; Kimambo, Ronald; Peng, Yun; Ishunga, Elison; Matasha, Edna; Matumu, Godfrey; Noronha, Rita; Ngilangwa, David P.

    2016-01-01

    Malaria and iron-deficient anemia during pregnancy pose considerable risks for the mother and newborn. Intermittent Preventive Treatment during pregnancy with sulphadoxine-pyrimethamine (IPTp-SP) and iron supplement to prevent anemia to all pregnant women receiving antenatal care (ANC) services is highly recommended. However, their compliance remains low. This study aimed at identifying factors influencing non-compliance of medications among pregnant women. A descriptive cross-sectional study was conducted in Simiyu region in northwest Tanzania using a structured questionnaire to collect data from 430 women who were pregnant or gave birth 12 months prior to data collection. Data were analyzed using non-parametric statistical analysis with STATA 10. Overall, 284 (66%) and 195 (45%) of interviewed women received IPTp-SP and iron supplementation during their ANC visits, respectively. The majority (85%) of women whom received medications were aware if they had received IPTp-SP or iron supplementation. Of those received IPTp-SP, only 11% took all the three doses, while the remaining 89% took only two doses or one dose. For women who received iron supplementation, 29% reported that they did not take any dose at all. Reasons given for not complying with regiments included not liking the medications and disapproval from male partners. Our findings suggest that IPTp-SP and iron supplement compliance among pregnant women in Simiyu region is low. Intensification of community education, further qualitative research and administration of medication through directly-observed therapy (DOT) are recommended to address the problem. PMID:27347981

  12. The Influence of Ozone Precursor Emissions from Four World Regions on Tropospheric Composition and Radiative Climate Forcing

    Science.gov (United States)

    Fry, Meridith; Naik, Vaishali; West, J. Jason; Schwarzkopf, M. Daniel; Fiore, Arlene M.; Collins, William J.; Dentener, Frank J.; Shindell, Drew T.; Atherton, Cyndi; Bergmann, Daniel; Duncan, Bryan N.; Hess, Peter; MacKenzie, Ian A.; Marmer, Elina; Schultz, Martin G.; Szopa, Sophie; Wild, Oliver; Zeng, Guang

    2012-01-01

    Ozone (O3) precursor emissions influence regional and global climate and air quality through changes in tropospheric O3 and oxidants, which also influence methane (CH4) and sulfate aerosols (SO4 (sup 2-)). We examine changes in the tropospheric composition of O3, CH4, SO4 (sup 2-) and global net radiative forcing (RF) for 20% reductions in global CH4 burden and in anthropogenic O3 precursor emissions (NOx, NMVOC, and CO) from four regions (East Asia, Europe and Northern Africa, North America, and South Asia) using the Task Force on Hemispheric Transport of Air Pollution Source-Receptor global chemical transport model (CTM) simulations, assessing uncertainty (mean plus or minus 1 standard deviation) across multiple CTMs. We evaluate steady state O3 responses, including long-term feedbacks via CH4. With a radiative transfer model that includes greenhouse gases and the aerosol direct effect, we find that regional NOx reductions produce global, annually averaged positive net RFs (0.2 plus or minus 0.6 to 1.7 2 mWm(sup -2)/Tg N yr(sup -1), with some variation among models. Negative net RFs result from reductions in global CH4 (-162.6 plus or minus 2 mWm(sup -2) for a change from 1760 to 1408 ppbv CH4) and regional NMVOC (-0.4 plus or minus 0.2 to 0.7 plus or minus 0.2 mWm(sup -2)/Tg C yr(sup -1) and CO emissions (-0.13 plus or minus 0.02 to -0.15 plus or minus 0.02 mWm(sup-2)/Tg CO yr(sup-1). Including the effect of O3 on CO2 uptake by vegetation likely makes these net RFs more negative by -1.9 to- 5.2 mWm(sup -2)/Tg N yr(sup -1), -0.2 to -0.7 mWm(sup -2)/Tg C yr(sup -1), and -0.02 to -0.05 mWm(sup -2)/ Tg CO yr(sup -1). Net RF impacts reflect the distribution of concentration changes, where RF is affected locally by changes in SO4 (sup -2), regionally to hemispherically by O3, and globally by CH4. Global annual average SO4 2 responses to oxidant changes range from 0.4 plus or minus 2.6 to -1.9 plus or minus 1.3 Gg for NOx reductions, 0.1 plus or minus 1.2 to -0.9 plus

  13. An annotated history of container candidate material selection

    International Nuclear Information System (INIS)

    This paper documents events in the Nevada Nuclear Waste Storage Investigations (NNWSI) Project that have influenced the selection of metals and alloys proposed for fabrication of waste package containers for permanent disposal of high-level nuclear waste in a repository at Yucca Mountain, Nevada. The time period from 1981 to 1988 is covered in this annotated history. The history traces the candidate materials that have been considered at different stages of site characterization planning activities. At present, six candidate materials are considered and described in the 1988 Consultation Draft of the NNWSI Site Characterization Plan (SCP). The six materials are grouped into two alloy families, copper-base materials and iron to nickel-base materials with an austenitic structure. The three austenitic candidates resulted from a 1983 survey of a longer list of candidate materials; the other three candidates resulted from a special request from DOE in 1984 to evaluate copper and copper-base alloys. 24 refs., 2 tabs

  14. Conserved CPEs in the p53 3' untranslated region influence mRNA stability and protein synthesis

    DEFF Research Database (Denmark)

    Rosenstierne, Maiken W; Vinther, Jeppe; Mittler, Gerhard;

    2008-01-01

    BACKGROUND: The 3' untranslated region (UTR) of p53 mRNA contains two conserved U-rich sequences resembling cytoplasmic polyadenylation elements (CPE). It is not known if these sequences regulate p53 expression by post-transcriptional mechanisms. MATERIALS AND METHODS: Stable p53 3'UTR reporter Ha......-type p53 3'UTR reduced mRNA steady state levels of the reporter gene and point mutations in the CPEs rescued the mRNA steady state levels in the MCF-7 cells, but not in the HaCaT cells. In both cell lines, the CPEs had a significant effect on translation of the reporter and influenced the effect of UV...... irradiation. Several proteins (including GAPDH, heterogeneous nuclear ribonucleoprotein (hnRNP) D and A/B) were identified from the MCF-7 cytoplasmic extracts that bound specifically to the CPEs. CONCLUSION: Two conserved CPEs in the p53 3'UTR regulate stability and translation of a reporter mRNA in non...

  15. Investigating the Influence of Anthropogenic Forcing on Observed Mean and Extreme Sea Level Pressure Trends over the Mediterranean Region

    Directory of Open Access Journals (Sweden)

    Armineh Barkhordarian

    2012-01-01

    Full Text Available We investigate whether the observed mean sea level pressure (SLP trends over the Mediterranean region in the period from 1975 to 2004 are significantly consistent with what 17 models projected as response of SLP to anthropogenic forcing (greenhouse gases and sulphate aerosols, GS. Obtained results indicate that the observed trends in mean SLP cannot be explained by natural (internal variability. Externally forced changes are detectable in all seasons, except spring. The large-scale component (spatial mean of the GS signal is detectable in all the 17 models in winter and in 12 of the 17 models in summer. However, the small-scale component (spatial anomalies about the spatial mean of GS signal is only detectable in winter within 11 of the 17 models. We also show that GS signal has a detectable influence on observed decreasing (increasing tendency in the frequencies of extremely low (high SLP days in winter and that these changes cannot be explained by internal climate variability. While the detection of GS forcing is robust in winter and summer, there are striking inconsistencies in autumn, where analysis points to the presence of an external forcing, which is not GS forcing.

  16. Influence of fault geometry and fault interaction on strain partitioning within western Sichuan and its adjacent region

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    There are several major active fault zones in the western Sichuan and its vicinity. Slip rates and seismicity vary on different fault zones. For example, slip rates on the Xianshuihe fault zone are higher than 10 mm/a. Its seismicity is also intense. Slip rates on the Longmenshan fault zone are low. However, Wenchuan Ms8.0 earthquake occurred on this fault zone in 2008. Here we study the impact of fault geometry on strain partitioning in the western Sichuan region using a three-dimensional viscoe- lastoplastic model. We conclude that the slip partitioning on the Xianshuihe-Xiaojiang fault presents as segmented, and it is related to fault geometry and fault structure. Slip rate is high on fault segment with simple geometry and structure, and vice versa. Strain rate outside the fault is localized around the fault segment with complex geometry and fault structure. Strain partitioning on the central section of the Xianshuihe-Xiaojiang fault zone is influenced by the interaction between the Anninghe-Zemuhe fault and the Daliangshan fault zone. Striking of the Longmenshan fault zone is nearly orthogonal to the direction of eastward extrusion in the Tibetan Plateau. It leads to low slip rate on the fault zone.

  17. Characteristics of heavy metal transfer and their influencing factors in different soil-crop systems of the industrialization region, China.

    Science.gov (United States)

    Chen, Hongyan; Yuan, Xuyin; Li, Tianyuan; Hu, Sun; Ji, Junfeng; Wang, Cheng

    2016-04-01

    Soil heavy metals and their bioaccumulation in agricultural products have attracted widespread concerns, yet the transfer and accumulation characteristics of heavy metals in different soil-crop systems was rarely investigated. Soil and crop samples were collected from the typical agricultural areas in the Yangtze River Delta region, China. The concentrations of Cu, Pb, Zn, Cd and Hg in the soils, roots and grains of rice (Oryza Sativa L.), wheat (Triticum L.) and canola (Brassica napus L.) were determined in this study. Transfer ability of heavy metals in soil-rice system was stronger than those in soil-wheat and soil-canola systems. The wheat showed a strong capacity to transfer Zn, Cu and Cd from root to the grain while canola presented a restricting effect to the intake of Cu and Cd. Soil pH and total organic matter were major factors influencing metal transfer from soil to rice, whereas soil Al2O3 contents presented a negative effect on heavy metal mobility in wheat and canola cultivation systems. The concentration of Zn and Cd in crop grains could well predicted according to the stepwise multiple linear regression models, which could help to quantitatively evaluate the ecologic risk of heavy metal accumulation in crops in the study area. PMID:26771531

  18. Hydrologic Conditions that Influence Streamflow Losses in a Karst Region of the Upper Peace River, Polk County, Florida

    Science.gov (United States)

    Metz, P.A.; Lewelling, B.R.

    2009-01-01

    The upper Peace River from Bartow to Fort Meade, Florida, is described as a groundwater recharge area, reflecting a reversal from historical groundwater discharge patterns that existed prior to the 1950s. The upper Peace River channel and floodplain are characterized by extensive karst development, with numerous fractures, crevasses, and sinks that have been eroded in the near-surface and underlying carbonate bedrock. With the reversal in groundwater head gradients, river water is lost to the underlying groundwater system through these karst features. An investigation was conducted to evaluate the hydrologic conditions that influence streamflow losses in the karst region of the upper Peace River. The upper Peace River is located in a basin that has been altered substantially by phosphate mining and increases in groundwater use. These alterations have changed groundwater flow patterns and caused streamflow declines through time. Hydrologic factors that have had the greatest influence on streamflow declines in the upper Peace River include the lowering of the potentiometric surfaces of the intermediate aquifer system and Upper Floridan aquifer beneath the riverbed elevation due to below-average rainfall (droughts), increases in groundwater use, and the presence of numerous karst features in the low-water channel and floodplain that enhance the loss of streamflow. Seepage runs conducted along the upper Peace River, from Bartow to Fort Meade, indicate that the greatest streamflow losses occurred along an approximate 2-mile section of the river beginning about 1 mile south of the Peace River at Bartow gaging station. Along the low-water and floodplain channel of this 2-mile section, there are about 10 prominent karst features that influence streamflow losses. Losses from the individual karst features ranged from 0.22 to 16 cubic feet per second based on measurements made between 2002 and 2007. The largest measured flow loss for all the karst features was about 50 cubic

  19. 40 shades of black: regional differences in vegetation response to a changing human influence in the Low Countries during the Dark Ages (AD 300-1000).

    Science.gov (United States)

    Gouw-Bouman, Marjolein T. I. J.; Donders, Timme H.; Hoek, Wim Z.

    2016-04-01

    During the Dark Ages, which includes the Late Roman Period (LRP, AD 300-500) and the Early Middle Ages (EMA, AD 500-1000), large scale vegetation development in Northwestern Europe is generally characterized by a forest regeneration. This forest redevelopment phase was not uniformous across the Netherlands. A comparison between existing pollen records shows that forest redevelopment started earlier and was more severe in the southern part of the Netherlands than in the northeastern Netherlands. The prevailing view advocates that the forest redevelopment is the result of a diminishing human influence on the landscape due to the collapse of the Roman Empire. Following this view, regional changes in forest regeneration are explained by varying population densities. However, existing climate-records indicate a colder and wetter climate during the Dark Ages and the geomorphological record points to a changing landscape. How and to what extent these climatic and environmental changes contributed to the changes in vegetation development or even to the decline of the Roman Empire is largely unknown. To understand the relative importance of the factors (climate, environment, economy and demography) influencing vegetation development it is important to accurately map regional differences in vegetation both on a regional and extra-regional scale. For an extra-regional overview all available pollen records in the Netherlands from this period are compiled to show differences in amplitude of the vegetation development during the Dark Ages. On a regional scale, vegetation reconstruction maps have been produced reflecting the influence of geological/geomorphological factors.

  20. Assessing the Influence of the PTTC Principal's Competency in ICT on the Teachers' Integration of ICT in Teaching Science in PTTCs in Nyanza Region, Kenya

    Science.gov (United States)

    Omwenga, Ezekiel; Nyabero, Charles; Okioma, Lazarous

    2015-01-01

    The study was conducted to assess the influence of Primary Teacher Training College (PTTC) principal's competency in ICT on the teacher's integration of ICT in teaching science in PTTC's in Nyanza region in Kenya. The one research question and one research hypothesis guided the study. The population comprised of 21 principals and 159 tutors. Data…

  1. Clinical indicators of child development in the capitals of nine Brazilian states: the influence of regional cultural factors

    Directory of Open Access Journals (Sweden)

    André Laranjeira de Carvalho

    2008-01-01

    Full Text Available OBJECTIVE: Evaluating the interaction between mother or caregiver and infant through the Clinical Indicators of Risks in Infant Development and investigating whether local and cultural influences during infant development affect these clinical indicators. INTRODUCTION: The Clinical Indicators of Risks in Infant Development was created in order to fully assess infants' development and the subjective relationship between the babies and their caregivers. The absence of two or more Clinical Indicators of Risks in Infant Developments suggests a possibly inadequate mental development. Given the continental size of Brazil and its accentuated cultural differences, one might question how trustworthy these indicators can be when applied to each of the geographical regions of the country. METHODS: This was a cross-sectional study with 737 infants from the capitals of 9 Brazilian states. The size of the initial sample population was based on a pilot study carried out in the cities of São Paulo and Brasília. The ages of children were grouped: 0-3 months, 4-7 months, 8-11 months and 12-18 months. The chi-square test was used together with analyses by the statistical software SPSS 13.0. RESULTS: Statistical analysis of results from the different municipalities against the total sample did not reveal any statistically significant differences. Municipalities represented were Belém (p=0.486, Brasília (p=0.371, Porto Alegre (p=0.987, Fortaleza (p=0.259, Recife (p=0.630, Salvador (0.370, São Paulo (p=0.238, Curitiba (p=0.870, and Rio de Janeiro (p= 0.06. DISCUSSION: Care for mental development should be considered a public health issue. Its evaluation and follow-up should be part of the already available mother-child assistance programs, which would then be considered to provide "full" care to children. CONCLUSIONS: Local habits and culture did not affect the results of the Clinical Indicators of Risks in Infant Development indicators. Clinical Indicators of

  2. A cross-species genetic analysis identifies candidate genes for mouse anxiety and human bipolar disorder

    Directory of Open Access Journals (Sweden)

    David G Ashbrook

    2015-07-01

    Full Text Available Bipolar disorder (BD is a significant neuropsychiatric disorder with a lifetime prevalence of ~1%. To identify genetic variants underlying BD genome-wide association studies (GWAS have been carried out. While many variants of small effect associated with BD have been identified few have yet been confirmed, partly because of the low power of GWAS due to multiple comparisons being made. Complementary mapping studies using murine models have identified genetic variants for behavioral traits linked to BD, often with high power, but these identified regions often contain too many genes for clear identification of candidate genes. In the current study we have aligned human BD GWAS results and mouse linkage studies to help define and evaluate candidate genes linked to BD, seeking to use the power of the mouse mapping with the precision of GWAS. We use quantitative trait mapping for open field test and elevated zero maze data in the largest mammalian model system, the BXD recombinant inbred mouse population, to identify genomic regions associated with these BD-like phenotypes. We then investigate these regions in whole genome data from the Psychiatric Genomics Consortium’s bipolar disorder GWAS to identify candidate genes associated with BD. Finally we establish the biological relevance and pathways of these genes in a comprehensive systems genetics analysis.We identify four genes associated with both mouse anxiety and human BD. While TNR is a novel candidate for BD, we can confirm previously suggested associations with CMYA5, MCTP1 and RXRG. A cross-species, systems genetics analysis shows that MCTP1, RXRG and TNR coexpress with genes linked to psychiatric disorders and identify the striatum as a potential site of action. CMYA5, MCTP1, RXRG and TNR are associated with mouse anxiety and human BD. We hypothesize that MCTP1, RXRG and TNR influence intercellular signaling in the striatum.

  3. A cross-species genetic analysis identifies candidate genes for mouse anxiety and human bipolar disorder.

    Science.gov (United States)

    Ashbrook, David G; Williams, Robert W; Lu, Lu; Hager, Reinmar

    2015-01-01

    Bipolar disorder (BD) is a significant neuropsychiatric disorder with a lifetime prevalence of ~1%. To identify genetic variants underlying BD genome-wide association studies (GWAS) have been carried out. While many variants of small effect associated with BD have been identified few have yet been confirmed, partly because of the low power of GWAS due to multiple comparisons being made. Complementary mapping studies using murine models have identified genetic variants for behavioral traits linked to BD, often with high power, but these identified regions often contain too many genes for clear identification of candidate genes. In the current study we have aligned human BD GWAS results and mouse linkage studies to help define and evaluate candidate genes linked to BD, seeking to use the power of the mouse mapping with the precision of GWAS. We use quantitative trait mapping for open field test and elevated zero maze data in the largest mammalian model system, the BXD recombinant inbred mouse population, to identify genomic regions associated with these BD-like phenotypes. We then investigate these regions in whole genome data from the Psychiatric Genomics Consortium's bipolar disorder GWAS to identify candidate genes associated with BD. Finally we establish the biological relevance and pathways of these genes in a comprehensive systems genetics analysis. We identify four genes associated with both mouse anxiety and human BD. While TNR is a novel candidate for BD, we can confirm previously suggested associations with CMYA5, MCTP1, and RXRG. A cross-species, systems genetics analysis shows that MCTP1, RXRG, and TNR coexpress with genes linked to psychiatric disorders and identify the striatum as a potential site of action. CMYA5, MCTP1, RXRG, and TNR are associated with mouse anxiety and human BD. We hypothesize that MCTP1, RXRG, and TNR influence intercellular signaling in the striatum. PMID:26190982

  4. Impacts of pore to regional scale variations in authigenic composition and texture on anthropogenically influenced fluid-rock interactions

    Science.gov (United States)

    Bowen, B. B.

    2015-12-01

    Diagenetic history plays a dominant role in determining the suitability of subsurface rock units as hosts for fluids that have societal importance. The performance of subsurface aquifers and storage facilities for CO2, natural gas, and liquid waste, is largely tied to the evolution of pore space and distribution and composition of authigenic minerals. While geoscientists may be well aware of the importance and nuances of diagenesis, project managers and decision-makers are unlikely to have a geologic understanding of determining factors such as burial history, fluid flow, and mineral thermodynamics. Thus, if falls to the geoscientists to effectively communicate meaningful conceptual models that adequately capture diagenetic heterogeneity and the potential for temporal changes with anthropogenically-induced changes in subsurface chemistry. This can be particularly difficult in subsurface systems that are sparsely sampled. Here, we look at the example of the basal Cambrian Mount Simon Sandstone and overlying Eau Claire Formation in the Illinois Basin, the respective reservoir and seal for the largest ongoing demonstration of anthropogenic CO2 sequestration in the United States. Relatively few cores are available to study the pore-scale composition and structure of these units, and those that are available show a complex and spatially variable diagenetic history. Compilation of past studies and new analyses from the Illinois Basin are combined to illustrate the burial history and fluid flow record that will influence how these units respond to the massive volumes of supercritical CO2 injected into the subsurface. Pore to regional scale differences in authigenic mineral composition and texture result in significantly different predicted fluid-rock interactions and various potential consequences of injection. This project provides examples of both successes and challenges associated with communicating the diagentic complexity to stakeholders and the potential

  5. Oceanographic Processes in the Region of Fluvial Influence of the Itajaí-Açu River

    Science.gov (United States)

    Schettini, C. A.; Truccolo, E. C.; Pereira, J.; Rörig, L. R.; Resgalla, C.

    2005-05-01

    The oceanographic processes in the region of fluvial influence (ROFI) of the Itajaí-Açu river were assessed through fourteen monthly surveys from November 2002 until December 2003. The main objective of this study was to investigate the effects of the fluvial riverine in the physical, biogeochemical and biological processes in the ROFI. Twenty eight sampling stations were positioned in five transects oriented in a radial shape from the estuarine mouth, with further two stations in the estuary. The transects length was about of 5-km each, reaching the isobath of 25 m. CTD, turbidity and dissolved oxygen profiles were acquired in all stations. Chlorophyll-a were sampled at surface in all stations. Water samples for determination of suspended particulate matter, dissolved inorganic nutrients, chlorophyll-a, phytoplankton and bacterioplankton were sampled in ten stations at surface and near bottom levels. The water samples stations were taken in selected stations to cover all studied area, where was also sampled zooplankton with a ring net. Current speed and direction were acquired with an ADCP moored about 1.5 km off the estuarine mouth at 10 m deep, from November 2002 until March 2003. The river discharge was below the average during most of the sampling period. Although, low salinity water was a permanent feature in the vicinity of the estuarine mouth. The estuarine plume dispersion was allways to north-northeast, what was observed by surface low salinity and higher concentrations of dissolved inorganic nutrients and chlorophyll-a. Below the surface layer, in all ROFI, the water column was dominated by salinity about of 33, named as Coastal Waters. Oceanic waters (salinity higher than 35) were observed only during the summer, with presence of Tropical Water and South Atlantic Central Water. Currents off the estuarine mouth presented strong low frequency signal, with dominance of longshore orientation. Despite of the limitation of the near surface ADCP data, it

  6. Regional MT survey across an archaean craton in south Australia. Influence of sedimentary basins and plate boundaries

    International Nuclear Information System (INIS)

    Complete text of publication follows. Long-period MT data at more than 200 stations have been collected across the Late Archaean - Early Proterozoic Gawler Craton, South Australia, during numerous field campaigns between 2002 and 2009. The total site coverage spans an area of approximately 800x500 km providing a unique dataset to image one of the oldest cratons in the world. The Gawler Craton is known for its mineral exploration potential, i.e. the IOCG Olympic Dam deposit (Heinson et al, 2006). MT data can help constrain the position of lithospheric structures which could provide clues to the genesis of mineral deposits throughout the region. Moreover, large parts of the craton are covered with sediments ranging from tens to thousands of meters in thickness. The sedimentary basins have a significant influence on the MT responses and if not taken into account can lead to erroneous results in a smooth inversion scheme due to their high conductances. We present 3D inversion models using a subset of sites in the period range of 10-10000s in order to image the subsurface resistivity distribution of the Gawler Craton. Initial 2D and 3D inversions of a subset of MT sites indicates an electrically resistive Archaean core. The thick sedimentary basins surrounding most of the Gawler Craton are taken into account by using starting models with the basins included as a priori information. Together with the inclusion of bathymetry data of the Southern Sea the inverse procedure has more constraints and is able to produce better results than an unconstrained inversion. The results provide additional constrains to the understanding of the evolution of the Archaean-Proterozoic Gawler Craton by imaging the crust and upper mantle. Tectonic models are largely based on limited outcrop due to thick regolith cover and domain boundaries inferred from potential field data. These can now be validated with the use of large-scale MT modelling.

  7. Relative Influence of Trans-Pacific and Regional Atmospheric Transport of PAHs in the Pacific Northwest, U.S.

    Science.gov (United States)

    Lafontaine, Scott; Schrlau, Jill; Butler, Jack; Jia, Yuling; Harper, Barbara; Harris, Stuart; Bramer, Lisa M; Waters, Katrina M; Harding, Anna; Simonich, Staci L Massey

    2015-12-01

    The relative influences of trans-Pacific and regional atmospheric transport on measured concentrations of polycyclic aromatic hydrocarbons (PAHs), PAH derivatives (nitro- (NPAH) and oxy-(OPAH)), organic carbon (OC), and particulate matter (PM) less than 2.5 μm in diameter (PM2.5) were investigated in the Pacific Northwest, U.S. in 2010-2011. Ambient high volume PM2.5 air samples were collected at two sites in the Pacific Northwest: (1.) Mount Bachelor Observatory (MBO) in the Oregon Cascade Range (2763 m above sea level (asl)) and 2.) Confederated Tribes of the Umatilla Indian Reservation (CTUIR) in the Columbia River Gorge (CRG) (954 m asl). At MBO, the 1,8-dinitropyrene concentration was significantly positively correlated with the time a sampled air mass spent over Asia, suggesting that this NPAH may be a good marker for trans-Pacific atmospheric transport. At CTUIR, NOx, CO2, and SO2 emissions from a 585 MW coal fired power plant, in Boardman OR, were found to be significantly positively correlated with PAH, OPAH, NPAH, OC, and PM2.5 concentrations. By comparing the Boardman Plant operational time frames when the plant was operating to when it was shut down, the plant was found to contribute a large percentage of the measured PAH (67%), NPAH (91%), OPAH (54%), PM2.5 (39%), and OC (38%) concentrations at CTUIR and the CRG prior to Spring 2011 and likely masked trans-Pacific atmospheric transport events to the CRG. Upgrades installed to the Boardman Plant in the spring of 2011 dramatically reduced the plant's contribution to PAH and OPAH concentrations (by ∼72% and ∼40%, respectively) at CTUIR and the CRG, but not NPAH, PM2.5 or OC concentrations. PMID:26151337

  8. Possible influence of atmospheric circulations on winter hazy pollution in Beijing-Tianjin-Hebei region, northern China

    Science.gov (United States)

    Zhang, Z.; Zhang, X.; Gong, D.; Kim, S.-J.; Mao, R.; Zhao, X.

    2015-08-01

    Using the daily records derived from the synoptic weather stations and the NCEP/NCAR and ERA-Interim reanalysis data, the variability of the winter hazy pollutions (indicated by the mean visibility and number of hazy days) in Beijing-Tianjin-Hebei (BTH) region during the period 1981 to 2015 and its relationship to the atmospheric circulations in middle-high latitude were analyzed in this study. The winter hazy pollution in BTH had distinct inter-annual and inter-decadal variabilities without a significant long-term trend. According to the spatial distribution of correlation coefficients, six atmospheric circulation indices (I1 to I6) were defined from the key areas in sea level pressure (SLP), zonal and meridional winds at 850 hPa (U850, V850), geopotential height field at 500 hPa (H500), zonal wind at 200 hPa (U200), and air temperature at 200 hPa (T200), respectively. All of the six indices have significant and stable correlations with the winter visibility and number of hazy days in BTH. Both the visibility and number of hazy days can be estimated well by using the six indices and fitting and the cross-validation with leave-N-out method, respectively. The high level of the prediction statistics and the reasonable mechanism suggested that the winter hazy pollutions in BTH can be forecasted or estimated credibly based on the optimized atmospheric circulation indices. However, we also noted that the statistic estimation models would be largely influenced by the artificial control of a pollutant discharge. Thus it is helpful for government decision-making departments to take actions in advance in dealing with probably severe hazy pollutions in BTH indicated by the atmospheric circulation conditions.

  9. Influence of region and site-specific factors on the degree of general validity of ecological and primary-energy-related assessments of biogas

    International Nuclear Information System (INIS)

    As described in this publication, since the early 1990s numerous studies based on the life cycle assessment methodology have been dedicated to assessments of different kinds of bioenergy in comparison with fossil energy resources in terms of their energy balance and environmental impact. On reviewing the results of these studies one finds a strikingly wide range of variation. One major factor of influence on the results of life cycle assessments, besides methodological factors such as the choice of allocation method, is the representativeness of the data used. Thus, widely varying results are also obtained when balance calculations and assessments are performed on energy crops with due consideration to regional and site-specific factors. To address this problem the present study endeavoured to identify region and site-specific factors and assess them in terms of their influence on the life cycle assessment of the cultivation and conversion to biogas of different kinds of energy crops. For this purpose the following questions were explored: What influence do region, site and equipment-specific factors have on the results of ecological and primary-energy-related assessments; and how large are the differences in results between region and site-specific assessments on the one hand and assessments based on general assumptions on the other? It transpires that the results of region and site-specific assessments differ from one another in terms of both the assessment of energy cropping and the assessment of the entire process chain of biogas production and conversion to electricity.

  10. Somatic point mutations in mtDNA control region are influenced by genetic background and associated with healthy aging: a GEHA study

    DEFF Research Database (Denmark)

    Rose, Giuseppina; Romeo, Giuseppe; Dato, Serena;

    2010-01-01

    Tissue specific somatic mutations occurring in the mtDNA control region have been proposed to provide a survival advantage. Data on twins and on relatives of long-lived subjects suggested that the occurrence/accumulation of these mutations may be genetically influenced. To further investigate....... We found a significant correlation of the mtDNA control region heteroplasmy between sibs, confirming a genetic influence on this phenomenon. Furthermore, many subjects showed heteroplasmy due to mutations different from the C150T transition. In these cases heteroplasmy was correlated within sibpairs...... performance and of mortality risk in the elderly. Our study provides new evidence on the relevance of mtDNA somatic mutations in aging and longevity and confirms that the occurrence of specific point mutations in the mtDNA control region may represent a strategy for the age-related remodelling of organismal...

  11. Regional estimation of soil C stocks and CO2 emissions as influenced by cropping systems and soil type

    Science.gov (United States)

    Farina, Roberta; Marchetti, Alessandro; Di Bene, Claudia

    2015-04-01

    Soil organic matter (SOM) is of crucial importance for agricultural soil quality and fertility. At global level soil contains about three times the carbon stored in the vegetation and about twice that present in the atmosphere. Soil could act as source and sink of carbon, influencing the balance of CO2 concentration and consequently the global climate. The sink/source ratio depends on many factors that encompass climate, soil characteristics and different land management practices. Thus, the relatively large gross exchange of GHGs between atmosphere and soils and the significant stocks of carbon in soils, may have significant impact on climate and on soil quality. To quantify the dynamics of C induced by land cover change and the spatial and temporal dynamics of C sources and sinks at regional and, potentially, at national and global scales, we propose a methodology, based on a bio-physical model combined with a spatial explicit database to estimate C stock changes and emissions/removals. The study has been conducted in a pilot region in Italy (Apulia, Foggia province), considering the typical cropping systems of the area, namely rainfed cereals, tomato, vineyard and olives. For this purpose, the model RothC10N (Farina et al., 2013), that simulates soil C dynamics, has been modified to work directly in batch using data of climate, soil (over 290 georeferenced soil profiles), annual agriculture land use (1200 observations) The C inputs from crops have been estimated using statistics and data from literature. The model was run to equilibrium for each point of soil, in order to make all the data homogeneous in terms of time. The obtained data were interpolate with geostatisical procedures, obtaining a set of 30x30 km grid with the initial soil C. The new layer produced, together with soil and land use layers, were used for a long-term run (12 years). Results showed that olive groves and vineyards were able to stock a considerable amount of C (from 0.4 to 1.5 t ha-1 y

  12. Uncovering the nucleus candidate for NGC 253

    CERN Document Server

    Günthardt, G I; Camperi, J A; Díaz, R J; Gomez, P L; Bosch, G; Schirmer, M

    2015-01-01

    NGC253 is the nearest spiral galaxy with a nuclear starburst which becomes the best candidate to study the relationship between starburst and AGN activity. However, this central region is veiled by large amounts of dust, and it has been so far unclear which is the true dynamical nucleus. The near infrared spectroscopy could be advantageous in order to shed light on the true nucleus identity. Using Flamingos-2 at Gemini South we have taken deep K-band spectra along the major axis and through the brightest infrared source. We present evidence showing that the brightest near infrared and mid infrared source in the central region, already known as radio source TH7 and so far considered just a stellar supercluster, in fact, presents various symptoms of a genuine galactic nucleus. Therefore, it should be considered a valid nucleus candidate. It is the most massive compact infrared object in the central region, located at 2.0" of the symmetry center of the galactic bar. Moreover, our data indicate that this object i...

  13. The influence of regional urbanization and abnormal weather conditions on the processes of human climatic adaptation on mountain resorts

    Science.gov (United States)

    Artamonova, M.; Golitsyn, G.; Senik, I.; Safronov, A.; Babyakin, A.; Efimenko, N.; Povolotskaya, N.; Topuriya, D.; Chalaya, E.

    2012-04-01

    This work is a further development in the study of weather pathogenic index (WPI) and negative influence of urbanization processes on the state of people's health with adaptation disorder. This problem is socially significant. According to the data of the WHO, in the world there are from 20 to 45% of healthy people and from 40 to 80% of people with chronic diseases who suffer from the raised meteosensitivity. As a result of our researches of meteosensitivity of people during their short-duration on mountain resorts there were used negative adaptive reactions (NAR) under 26 routine tests, stress-reactions under L.H. Garkavi's hemogram, vegetative indices, tests of neuro-vascular reactivity, signs of imbalance of vegetative and neurohumoral regulation according to the data of biorhythm fractal analysis and sudden aggravations of diseases (SAD) as an indicator of negative climatic and urbanization influence. In 2010-2011 the Caucasian mountain resorts were having long periods of climatic anomalies, strengthening of anthropogenic emissions and forest fires when record-breaking high waves of NAR and SAD were noticed. There have also been specified indices ranks of weather pathogenicity from results of comparison of health characteristics with indicators of synoptico-dynamic processes according to Weather Research and Forecasting model (WRF); air ionization N+, N-, N+/N- spectra of aerosol particles (the size from 500 to 20000 nanometers) and concentrations of chemically active gases (O3, NO, NO2, ), volatile phytoorganic substances in the surface atmosphere, bactericidal characteristics of vegetation by criterion χ2 (not above 0,05). It has allowed us to develop new physiological optimum borders, norm and pessimum, to classify emergency ecologo-weather situations, to develop a new techniques of their forecasting and prevention of meteopathic reactions with meteosensitive patients (Method of treatment and the early (emergency) and planned prevention meteopatic reactions

  14. A multi-model analysis of the resolution influence on precipitation climatology in the Gulf Stream region

    Science.gov (United States)

    Feng, Xuelei; Huang, Bohua; Kirtman, Ben P.; Kinter, James L.; Chiu, Long S.

    2016-05-01

    Using climate simulations from coupled and uncoupled general circulation models, this study investigates the influence of horizontal resolution in both atmospheric and oceanic model components on the mean precipitation over the Gulf Stream (GS) region. For this purpose, three sets of model experiments are analyzed. The first two examine the effects of increasing horizontal resolution of an atmospheric general circulation model (AGCM) gradually from 100 to 10 km under fixed oceanic settings. Specifically, the AGCM is either forced with prescribed observed sea surface temperature (SST) (the first case) or coupled to a non-eddy-resolving ocean general circulation model (OGCM) at a fixed horizontal resolution near 100 km (the second case). The third set of experiments examines the effects of the oceanic resolution with a pair of long-term simulations by another coupled ocean-atmosphere general circulation model (CGCM), in which the OGCM is run respectively at non-eddy-resolving (100 km) and eddy-resolving (10 km) resolutions, while the AGCM resolution remains fixed at 50 km for both runs. In general, all simulations qualitatively reproduce the gross features of the mean GS precipitation and its annual cycle. At similar AGCM resolutions, the uncoupled models produce a GS rain band that is more realistic in both structure and strength compared to the coupled models with non-eddy-resolving oceans. This is because the prescribed observed SST better represents the gradient near the oceanic front than the non-eddy-resolving OGCMs simulate. An increase from the baseline AGCM resolution produces enhanced climatological GS precipitation, both large-scale and convective, with the latter more tightly confined to the oceanic front. The enhancement, however, is moderate and further increases in resolution achieves diminishing results. On the other hand, an increase in oceanic resolution from non-eddy-resolving to eddy resolving scheme results in more consistent simulations with

  15. Insights on organic aerosol aging and the influence of coal combustion at a regional receptor site of central eastern China

    Directory of Open Access Journals (Sweden)

    W. W. Hu

    2013-10-01

    Full Text Available In order to understand the aging and processing of organic aerosols (OA, an intensive field campaign (Campaign of Air Pollution at Typical Coastal Areas IN Eastern China, CAPTAIN was conducted March–April at a receptor site (a Changdao island in central eastern China. Multiple fast aerosol and gas measurement instruments were used during the campaign, including a high resolution time-of-flight aerosol mass spectrometer (HR-ToF-AMS that was applied to measure mass concentrations and non-refractory chemical components of submicron particles (PM1nr. The average mass concentration of PM1(PM1nr+black carbon was 47 ± 36 μg m−3 during the campaign and showed distinct variation, depending on back trajectories and their overlap with source regions. Organic aerosol (OA is the largest component of PM1 (30%, followed by nitrate (28%, sulfate (19%, ammonium (15%, black carbon (6%, and chloride (3%. Four OA components were resolved by positive matrix factorization (PMF of the high-resolution spectra, including low-volatility oxygenated organic aerosol (LV-OOA, semi-volatile oxygenated OA (SV-OOA, hydrocarbon-like OA (HOA and a coal combustion OA (CCOA. The mass spectrum of CCOA had high abundance of fragments from polycyclic aromatic hydrocarbons (PAHs (m/z 128, 152, 178, etc.. The average atomic ratio of oxygen to carbon in OA (O / C at Changdao was 0.59, which is comparable to other field studies reported at locations downwind of large pollution sources, indicating the oxidized nature of most OA during the campaign. The evolution of OA elemental composition in the van Krevelen diagram (H / C vs. O / C showed a slope of −0.63; however, the OA influenced by coal combustion exhibits a completely different evolution that appears dominated by physical mixing. The aging of organic aerosols vs. photochemical age was investigated. It was shown that OA / ΔCO, as well as LV-OOA / ΔCO and SV-OOA / ΔCO, positively correlated with photochemical age. LV

  16. Synoptic influences on springtime tropospheric O3 and CO over the North American export region observed by TES

    Directory of Open Access Journals (Sweden)

    R. Talbot

    2008-11-01

    Full Text Available The relationship between synoptic circulation patterns over the western North Atlantic Ocean in spring (March, April, and May and tropospheric O3 and CO was investigated using retrievals from the Tropospheric Emission Spectrometer (TES for 2005 and 2006. Seasonal composites of TES retrievals reprocessed to remove the artificial geographic structure added from the a priori revealed a channel of slightly elevated O3 (>55 ppbv and CO (>115 ppbv at the 681 hPa retrieval level between 30° N and 45° N extending from North America out over the Atlantic Ocean. Ozone and CO in this region were correlated at r=0.32 with a slope value of 0.16 indicative of the overall impact of photochemical chemical processes in North American continental export. Composites of TES retrievals for the six predominant circulation patterns identified as map types from sea level pressure fields of the NCEP FNL analyses showed large variability in the distribution of tropospheric O3. Map types featuring cyclones near the US east coast (MAM2–MAM5 produced the greatest export to the lower free troposphere with O3>65 ppbv and O3-CO slopes ranging 0.25–0.36. HYSPLIT backward trajectories indicated that the high O3 levels were possibly a result of pollutants lofted to the free troposphere by the warm conveyor belt (WCB of a cyclone. An important finding was that pollutant export occurred in the main WCB branch to the east of the cyclone and in a secondary branch circling to the back of the cyclone center. Conversely, a map type featuring a large anticyclone dominating the flow over the US east coast (MAM6 restricted export with O3 levels generally <45 ppbv and an O3-CO slope near zero. There was also evidence of stratospheric intrusions particularly to the north of 45° N in the 316 hPa composites predominately for MAM1 which featured a large cyclone near Newfoundland. However, it was not clear from the available data that these intrusions had a strong impact on the 681 hPa O3

  17. Study on the atmospheric boundary layer and its influence on regional air quality over the Pearl River delta

    Directory of Open Access Journals (Sweden)

    M. Wu

    2013-03-01

    Full Text Available To study the structure of atmospheric boundary layer (ABL and its influence on regional air quality over the Pearl River delta (PRD, two ABL intensive observations were conducted at Panyu (urban station and Xinken (non-urban station, near estuary of PRD during October 2004 and July 2006, respectively. Based on the ABL intensive observation data analysis, the typical weather condition type associated with poor air quality over PRD could be summarized into two kinds: the warmed period before cold front (WPBCF and the subsidence period controlled by tropical cyclone (SPCTC. Two typical polluted cases (affected by WPBCF and SPCTC, respectively and one clean (not-polluted case were chosen for detail analysis. It was found that the continuously low or calm ground wind would lead to pollutant accumulation. The local circulation, such as sea–land breezes and heat–island circulation, played an important role in these polluted cases. The recirculation was significant in polluted cases; steady transport occurred in the clean case. Ventilation index (VI was quite different between polluted cases and the clean case: in WPBCF cases, the peak VI was from 184 to 3555 m2 s−1; on SPCTC days, the peak VI was from 1066 to 4363 m2 s−1; on the clean day, the peak VI was 10 885 m2 s−1 and much larger than all polluted cases. The 24-h average VI on polluted days was from 169 to 2858 m2 s−1 and also much smaller than that of the clean day. VI is a good reference index for pollution judgment. The peak mixing heights were smaller than 700 m in WPBCF cases, and were smaller than 800 m in SPCTC cases. During WPBCF polluted case, only surface inversion layer appeared. In the period of land breeze, surface inversion layer height was about 50 m, but in the period of sea breeze, surface inversion layer height would increase, and reach the maximum height, which was about 600 m. During SPCTC polluted case, there were several inversion layers that appeared at different

  18. Influence of university network structures on forming the network environment of regional economy (on the example of national research universities of Tatarstan Republic

    Directory of Open Access Journals (Sweden)

    Darya-Anna Alekseevna Kaibiyainen

    2015-03-01

    Full Text Available Objective to elaborate theoretical and applied aspects of the processes of forming the new network institutional environment of the Russian regional economy under the influence of the developing integral educational network structures basing on the study of the experience of national research universities of Tatarstan Republic Methods general scientific logical methods of analysis and synthesis induction and deduction scientific abstraction as well as the method of systemicfunctional analysis. Results the practical examples are revealed and analyzed of introducing the new network integral principles into the functioning of national research universities which have a real economic effect and influencing such indicators of regional economy as the growth of employment reduction of unemployment etc. Scientific novelty problems of network structures development in the Russian education have not been thoroughly studied yet. The article analyzes the experience reveals and describes the methods and techniques of forming the network educational structures in the functioning of national research universities in Tatarstan Republic Practical value the author shows the ability of network university structures not only to play a significant role forming the new institutional environment of the regional economy but also to influence the macro and microeconomic indicators of development of the region and the country. nbsp

  19. Temperature and altitudinal influence on karst dripwater chemistry: Implications for regional-scale palaeoclimate reconstructions from speleothems

    Science.gov (United States)

    Borsato, Andrea; Johnston, Vanessa E.; Frisia, Silvia; Miorandi, Renza; Corradini, Flavio

    2016-03-01

    The reconstruction of robust past climate records from speleothems requires a prior understanding of the environmental and hydrological conditions that lead to speleothem formation and the chemical signals encoded within them. On regional-scales, there has been little quantification of the dependency of cave dripwater geochemistry on meteorology (net infiltration, temperature), environmental and geographical factors (elevation, latitude, soil activity, vegetation cover, atmospheric aerosol composition) and geological properties of the aquifer (lithology, porosity and thickness). In the present study, we analysed over 200 karst waters collected in 11 caves of the Trentino region (NE Italy). The caves span sub-humid Mediterranean to cold-humid temperate climates and infiltration elevations (Zinf) ranging from 355 to 2400 m a.s.l., corresponding to infiltration mean annual temperatures (MATinf) between 12 and 0 °C. Since all the caves developed in pure carbonate rocks, soil pCO2 is found to be the main factor controlling the carbonate dissolution. For this reason, the parameters controlling the carbonate-carbonic acid system and calcite saturation state (SICC) are directly correlated with the MATinf, which influences the vegetation zones and eventually the production of CO2 in the soil. SICC linearly depends on MATinf (SICC = 0.09 MATinf - 0.4) and SICC = 0 is reached at Zinf = 1.66 km a.s.l., corresponding to a MATinf = 4.4 °C. This point identifies the "speleothem limit" defined here as the elevation (or corresponding MATinf) above which no sparitic speleothem precipitation usually occurs. We demonstrate that due to temperature-forced changes in the soil and vegetation and subsequently SICC, the speleothem limit shifts to higher altitudes during maximum interglacial conditions. Speleothems from high altitude caves (1.5-2.5 km a.s.l.) thus can identify optimum interglacial periods. By contrast, speleothems formed at lower altitudes are better suited as archives of

  20. Climate variations in the Circum-Alpine region and their influence on Neolithic-Bronze Age lacustrine communities displacement and\\or cultural adaptation

    Directory of Open Access Journals (Sweden)

    Francesco Menotti

    2009-12-01

    Full Text Available Because of its delicate balance, the hydrological system of the Alpine region is affected immediately by climatic variations. The most obvious evidence of hydrologic instability is reflected by natural water basins in particular rivers and lakes. Caused by climate change, but catalyzed by a myriad of environmental factors, the water levels of lakes and other natural water reservoirs fluctuate, influencing people who live in their proximity. In some cases, the irregular pattern of human occupation around prehistoric Circum-Alpine lakes shows a remarkable affinity to climatic oscillations. People’s responses to environmental influence are nevertheless unpredictable, and sometimes illogical.

  1. Sacral landscape and its influence on the tourism space development in the region (based on the example of Western Pomerania region NW Poland)

    OpenAIRE

    Tomasz Duda

    2014-01-01

    Formed through the centuries, cultural landscape of the region includes not only the material realm in the form of numerous historical buildings, monuments and other evidences of local society’s development, but also significant immaterial realm, which manifests itself in the form of spiritual heritage, faith, tradition, customs and language. Interesting, often unique in terms of religious and historical point of view, religious buildings, as well as traditional pilgrimage routes and local sh...

  2. Regional dynamics and external influences in the discussions about the model of economic integration in Latin America

    OpenAIRE

    BRICEÑO-RUIZ, José

    2014-01-01

    This paper analyses the current scenario of regional economic integration in Latin America. Thus, it is argued that economic integration in this region is currently developing in three axes: an open integration axis (represented by the Pacific Alliance); a revisionist axis (symbolized by the Southern Common Market –Mercosur-) and an anti-systemic axis (represented by the Bolivarian Alliance for the People of our America –ALBA-). In each of these initiatives, diverse models of regional economi...

  3. An empirical research on the influencing factors of regional CO2 emission: Evidence from Beijing city, China

    OpenAIRE

    Zhaohua Wang; Fangchao Yin; Yixiang Zhang; Xian Zhang

    2011-01-01

    In order to further study the realization of carbon intensity target, find the key influencing factors of CO2 emissions, and explore the path of developing low-carbon economy, this paper empirically studied the influences of urbanization level, economic level, industry proportion, tertiary industry proportion, energy intensity and R&D output on CO2 emissions in Beijing using improved STIRPAT (stochastic impacts by regression on population, affluence and technology) model. The model is examine...

  4. Resequencing and association analysis of coding regions at twenty candidate genes suggest a role for rare risk variation at AKAP9 and protective variation at NRXN1 in schizophrenia susceptibility.

    Science.gov (United States)

    Suárez-Rama, José Javier; Arrojo, Manuel; Sobrino, Beatriz; Amigo, Jorge; Brenlla, Julio; Agra, Santiago; Paz, Eduardo; Brión, María; Carracedo, Ángel; Páramo, Mario; Costas, Javier

    2015-01-01

    A fraction of genetic risk to develop schizophrenia may be due to low-frequency variants. This multistep study attempted to find low-frequency variants of high effect at coding regions of eleven schizophrenia susceptibility genes supported by genome-wide association studies (GWAS) and nine genes for the DISC1 interactome, a susceptibility gene-set. During the discovery step, a total of 125 kb per sample were resequenced in 153 schizophrenia patients and 153 controls from Galicia (NW Spain), and the cumulative role of low-frequency variants at a gene or at the DISC1 gene-set were analyzed by burden and variance-based tests. Relevant results were meta-analyzed when appropriate data were available. In addition, case-only putative damaging variants were genotyped in a further 419 cases and 398 controls. The discovery step revealed a protective effect of rare missense variants at NRXN1, a result supported by meta-analysis (OR = 0.67, 95% CI: 0.47-0.94, P = 0.021, based on 3848 patients and 3896 controls from six studies). The follow-up step based on case-only putative damaging variants revealed a promising risk variant at AKAP9. This variant, K873R, reached nominal significance after inclusion of 240 additional Spanish controls from databases. The variant, located in an ADCY2 binding region, is absent from large public databases. Interestingly, GWAS revealed an association between common ADCY2 variants and bipolar disorder, a disorder with considerable genetic overlap with schizophrenia. These data suggest a role of rare missense variants at NRXN1 and AKAP9 in schizophrenia susceptibility, probably related to alteration of the excitatory/inhibitory synaptic balance, deserving further investigation. PMID:25943950

  5. Candidate gene prioritization with Endeavour.

    Science.gov (United States)

    Tranchevent, Léon-Charles; Ardeshirdavani, Amin; ElShal, Sarah; Alcaide, Daniel; Aerts, Jan; Auboeuf, Didier; Moreau, Yves

    2016-07-01

    Genomic studies and high-throughput experiments often produce large lists of candidate genes among which only a small fraction are truly relevant to the disease, phenotype or biological process of interest. Gene prioritization tackles this problem by ranking candidate genes by profiling candidates across multiple genomic data sources and integrating this heterogeneous information into a global ranking. We describe an extended version of our gene prioritization method, Endeavour, now available for six species and integrating 75 data sources. The performance (Area Under the Curve) of Endeavour on cross-validation benchmarks using 'gold standard' gene sets varies from 88% (for human phenotypes) to 95% (for worm gene function). In addition, we have also validated our approach using a time-stamped benchmark derived from the Human Phenotype Ontology, which provides a setting close to prospective validation. With this benchmark, using 3854 novel gene-phenotype associations, we observe a performance of 82%. Altogether, our results indicate that this extended version of Endeavour efficiently prioritizes candidate genes. The Endeavour web server is freely available at https://endeavour.esat.kuleuven.be/. PMID:27131783

  6. Empathy Development in Teacher Candidates

    Science.gov (United States)

    Boyer, Wanda

    2010-01-01

    Using a grounded theory research design, the author examined 180 reflective essays of teacher candidates who participated in a "Learning Process Project," in which they were asked to synthesize and document their discoveries about the learning process over the course of a completely new learning experience as naive learners. This study explored…

  7. Candidate Prediction Models and Methods

    DEFF Research Database (Denmark)

    Nielsen, Henrik Aalborg; Nielsen, Torben Skov; Madsen, Henrik;

    2005-01-01

    This document lists candidate prediction models for Work Package 3 (WP3) of the PSO-project called ``Intelligent wind power prediction systems'' (FU4101). The main focus is on the models transforming numerical weather predictions into predictions of power production. The document also outlines the...

  8. MM5 Simulations of the China Regional Climate During the LGM.Ⅰ: Influence of CO2 and Earth Orbit Change

    Institute of Scientific and Technical Information of China (English)

    LIU yu; HE Jinhai; LI Weiliang; CHEN Longxun

    2008-01-01

    Using a regional climate model MM5 nested to an atmospheric global climate model CCM3, a series of simulations and sensitivity experiments have been performed to investigate the relative Last Glacial Maximum (LGM) climate response to different mechanisms over China. Model simulations of the present day (PD) climate and the LGM climate change are in good agreement with the observation data and geological records, especially in the simulation of precipitation change. Under the PD and LGM climate, changes of earth orbital parameters have a small influence on the annual mean temperature over China.However, the magnitude of the effect shows a seasonal pattern, with a significant response in winter. Thus,this influence cannot be neglected. During the LGM, CO2 concentration reached its lowest point to 200 ppmv. This results in a temperature decrease over China. The influences of CO2 concentration on climate show seasonal and regional patterns as well, with a significant influence in winter. On the contrary, CO2concentration has less impact in summer season. In some cases, temperature even increases with decreasing in CO2 concentration. This temperature increase is the outcome of decrease in cloud amount; hence increase the solar radiation that reached the earth's surface. This result suggests that cloud amount plays a very important role in climate change and could direct the response patterns of some climate variables such as temperature during certain periods and over certain regions. In the Tibetan Plateau, the temperature responses to changes of the above two factors are generally weaker than those in other regions because the cloud amount in this area is generally more than in the other areas. Relative to the current climate, changes in orbital parameters have less impact on the LGM climate than changes in CO2 concentration. However,both factors have rather less contributions to the climate change in the LGM. About 3%-10% changes in the annual mean temperature are

  9. Comparison of region-of-influence methods for estimating high quantiles of precipitation in a dense dataset in the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Gaál, Ladislav; Kyselý, Jan

    2009-01-01

    Roč. 13, č. 11 (2009), s. 2203-2219. ISSN 1027-5606 R&D Projects: GA AV ČR KJB300420801 Institutional research plan: CEZ:AV0Z30420517 Keywords : heavy precipitation * extreme value analysis * region-of-influence method * central Europe Subject RIV: DG - Athmosphere Sciences, Meteorology Impact factor: 2.462, year: 2009 http://www.hydrol-earth-syst-sci.net/13/2203/2009/

  10. Factors influencing elective science students’ perception of their Biology classroom environment in low and high academic achieving schools in the Central Region of Ghana

    OpenAIRE

    Otami, Deodat Charles; Ampiah, Joseph Ghartey; Anthony-Krueger, Christian

    2012-01-01

    The study investigated factors influencing elective science students’ perception of their Biology classroom environment in low and high academic achieving senior secondary schools in the Central Region of Ghana. The cross-sectional survey research design was adopted. Participants were 356 third-year elective science students, selection through a multi-stage sampling technique. Data were obtained using the Biology Classroom Environment Questionnaire (BCEQ). This was after the senior secondary ...

  11. The influence of regional health system characteristics on the surgical management and receipt of post operative radiation therapy for glioblastoma multiforme

    OpenAIRE

    Aneja, Sanjay; Khullar, Dhruv; Yu, James B.

    2013-01-01

    Despite a known optimal treatment protocol for the management of glioblastoma multiforme (GBM), many patients fail to receive complete surgical resection or postoperative radiation therapy (PORT). The underlying reasons behind this disparity are unclear. Our study investigates the influence of regional health system resources on the surgical management and PORT receipt in patients with GBM. Surgical intervention, PORT receipt and patient data for patients diagnosed with GBM were obtained from...

  12. Socio-occupational class, region of birth and maternal age: influence on time to detection of cryptorchidism (undescended testes): a Danish nationwide register study

    OpenAIRE

    Hougaard, Karin Sørig; Larsen, Ann Dyreborg; Hannerz, Harald; Andersen, Anne-Marie Nybo; Jørgensen, Kristian Tore; Toft, Gunnar Vase; Bonde, Jens Peter; Jensen, Morten Søndergaard

    2014-01-01

    Background Cryptorchidism (undescended testes) is associated with poor male fertility, but can be alleviated and fertility preserved to some degree by early detection and treatment. Here we assess the influence of socio-occupational class, geographical region, maternal age and birth cohort on time to detection and correction of cryptorchidism. Methods All boys born in Denmark, 1981 to 1987 or 1988 to 1994, with a diagnosis of cryptorchidism were identified in nationwide registers. The boys we...

  13. Numerical simulation of the influence of lower-crustal flow on the deformation of the Sichuan-Yunnan Region

    Institute of Scientific and Technical Information of China (English)

    WANG Hui; CAO Jian-ling; ZHANG Huai; ZHANG Guo-min; SHI Yao-lin; SHEN Xu-hui

    2007-01-01

    On the basis of distribution of active fault and regional rheological structure, a three-dimensional finite element model of Sichuan-Yunnan region, China, is constructed to simulate contemporary crustal motion and stress distribution and discuss the dynamic mechanism of crustal motion and deformation in the Sichuan-Yunnan region. Linear Maxwell visco-elastic model is applied, which includes the active fault zones, the elastic upper crust and viscous lower crust and upper mantle. Four different models with different boundary conditions and deep structure are calculated. Some conclusions are drawn through comparison. Firstly, the crustal rotation about the eastern syntaxis of the Himalaya in the Sicuan-Yunnan region may be controlled by the special dynamic boundary condition. The drag force of the lower-crust on the upper crust is not negligible. At the same time, the main active fault zones play an important role in the contemporary crustal motion and deformation in Sichuan-Yunnan region.

  14. CRISPLD2: a novel NSCLP candidate gene.

    Science.gov (United States)

    Chiquet, Brett T; Lidral, Andrew C; Stal, Samuel; Mulliken, John B; Moreno, Lina M; Arcos-Burgos, Mauricio; Arco-Burgos, Mauricio; Valencia-Ramirez, Consuelo; Blanton, Susan H; Hecht, Jacqueline T

    2007-09-15

    Non-syndromic cleft lip with or without cleft palate (NSCLP) results from the complex interaction between genes and environmental factors. Candidate gene analysis and genome scans have been employed to identify the genes contributing to NSCLP. In this study, we evaluated the 16q24.1 chromosomal region, which has been identified by multiple genome scans as an NSCLP region of interest. Two candidate genes were found in the region: interferon regulatory factor 8 (IRF8) and cysteine-rich secretory protein LCCL domain containing 2 (CRISPLD2). Initially, Caucasian and Hispanic NSCLP multiplex families and simplex parent-child trios were genotyped for single nucleotide polymorphisms (SNPs) in both IRF8 and CRISPLD2. CRISPLD2 was subsequently genotyped in a data set comprised of NSCLP families from Colombia, South America. Linkage disequilibrium analysis identified a significant association between CRISPLD2 and NSCLP in both our Caucasian and Hispanic NSCLP cohorts. SNP rs1546124 and haplotypes between rs1546124 and either rs4783099 or rs16974880 were significant in the Caucasian multiplex population (P=0.01, P=0.002 and P=0.001, respectively). An altered transmission of CRISPLD2 SNPs rs8061351 (P=0.02) and rs2326398 (P=0.06) was detected in the Hispanic population. No association was found between CRISPLD2 and our Colombian population or IRF8 and NSCLP. In situ hybridization showed that CRISPLD2 is expressed in the mandible, palate and nasopharynx regions during craniofacial development at E13.5-E17.5, respectively. Altogether, these data suggest that genetic variation in CRISPLD2 has a role in the etiology of NSCLP. PMID:17616516

  15. Characterization of a human X-linked gene from the DXS732E locus in the candidate region for the anhidrotic ectodermal dysplasia (EDA) gene (Xq13.1)

    Energy Technology Data Exchange (ETDEWEB)

    Gault, J.; Zonana, J. [Oregon Health Sciences Univ., Portland, OR (United States); Zeltinger, J. [Univ. of Washington, Seattle, WA (United States)] [and others

    1994-09-01

    A conserved mouse genomic clone was used to identify a homologous human genomic clone (the DXS732E locus), which was subsequently employed to isolate cDNAs from a human fetal brain library. Nine unique overlapping cDNAs were isolated, and sequences analysis of 3.9 kb identified a putative 1 kb ORF. GRAIL analysis of the sequence supported the hypothesis that the putative ORF was coding sequence, and Prosite analysis of the putative ORF identified potential glycosylation and phosphorylation sites. The 5{prime} end of the gene maps within a CpG island, and comparison of cDNA sequences indicate the gene is alternatively spliced at its 3{prime} end. Northern analysis and RT-PCR indicate that two different sized messages appear to be expressed with the gene expressed in human fetal kidney, intestine, brain, and muscle. The gene is expressed in 77 day human skin, a time when hair follicle formation occurs. Anhidrotic ectodermal dysplasia (EDA) results in the abnormal morphogenesis of hair, teeth and eccrine sweat glands. A positional cloning strategy towards cloning the EDA gene had been used, and deletion and X-autosome translocation patients have been useful in further delimiting the EDA region. The present gene at the DXS732E locus is partially deleted in one EDA patient who does not have other apparent abnormalities. No rearrangements of the gene have been detected in two female X-autosome translocation EDA patients, nor in four additional male patients with submicroscopic molecular deletions.

  16. Regional brain shrinkage and change in cognitive performance over two years: The bidirectional influences of the brain and cognitive reserve factors.

    Science.gov (United States)

    Persson, Ninni; Ghisletta, Paolo; Dahle, Cheryl L; Bender, Andrew R; Yang, Yiqin; Yuan, Peng; Daugherty, Ana M; Raz, Naftali

    2016-02-01

    We examined relationships between regional brain shrinkage and changes in cognitive performance, while taking into account the influence of chronological age, vascular risk, Apolipoprotein E variant and socioeconomic status. Regional brain volumes and cognitive performance were assessed in 167 healthy adults (age 19-79 at baseline), 90 of whom returned for the follow-up after two years. Brain volumes were measured in six regions of interest (ROIs): lateral prefrontal cortex (LPFC), prefrontal white matter (PFw), hippocampus (Hc), parahippocampal gyrus (PhG), cerebellar hemispheres (CbH), and primary visual cortex (VC), and cognitive performance was evaluated in three domains: episodic memory (EM), fluid intelligence (Gf), and vocabulary (V). Average volume loss was observed in Hc, PhG and CbH, but reliable individual differences were noted in all examined ROIs. Average positive change was observed in EM and V performance but not in Gf scores, yet only the last evidenced individual differences in change. We observed reciprocal influences among neuroanatomical and cognitive variables. Larger brain volumes at baseline predicted greater individual gains in Gf, but differences in LPFC volume change were in part explained by baseline level of cognitive performance. In one region (PFw), individual change in volume was coupled with change in Gf. Larger initial brain volumes did not predict slower shrinkage. The results underscore the complex role of brain maintenance and cognitive reserve in adult development. PMID:26584866

  17. The influence of the violation of scaling in the different regions of X on the γ-families characteristics

    International Nuclear Information System (INIS)

    Some characteristics of γ-families simulated with the models of scaling in the fragmentation region are considered. It is investigated the dependence of some γ-families characteristics on 1) the speed of inccrease of production cross-sectionn 2) the composition of primary cosmic rays and 3) their energy spectrum; 4) the width of the part of pionization region where scaling is violated

  18. Czechs and Germans – the case of growing regional cooperation influenced by the europeisation of mutual relations

    Czech Academy of Sciences Publication Activity Database

    Houžvička, Václav

    Yamagata: Fakulta humanitních studií Univerzity Yamagata, 2008, s. 3-21. [14. výroční konference Asociace pro regionální studia severovýchodní Asie. Yamagata (JP), 27.09.2008-28.09.2008] Institutional research plan: CEZ:AV0Z70280505 Keywords : Regional Cooperation * Integration * Globalization Subject RIV: AO - Sociology, Demography

  19. Influences of polarization effect and p-region doping concentration on the photocurrent response of solar-blind p—i—n avalanche photodiodes

    International Nuclear Information System (INIS)

    The influences of polarization and p-region doping concentration on the photocurrent response of Al0.4Ga0.6N/Al0.4Ga0.6N /Al0.65Ga0.35N p—i—n avalanche photodetector are studied in a wide range of reverse bias voltages. The simulation results indicate that the photocurrent under high inverse bias voltage decreases with the increase of polarization effect, but increases rapidly with the increase of effective doping concentration in p-type region. These phenomena are analyzed based on the calculations of the intensity and distribution of the electric field. A high p-region doping concentration in the p—i—n avalanche photodetector is shown to be important for the efficient compensation for the detrimental polarization-induced electrostatic field. (interdisciplinary physics and related areas of science and technology)

  20. The Influence of Industrial Air Pollution Forest Lichens at Tomaszów Mazowiecki Region (Central Poland)

    OpenAIRE

    Krystyna Czyżewska

    2014-01-01

    The influence of mixed gases pollution (SO2, H2S and CS2) on epiphytic and epixylic lichens growing on Pinus sylvestris in the nature conditions is the matter of consideration. In the case of some lichens, e.g. Lecanora conizaeoides, Scoliciosporum chlorococcum and Thelocarpon laureri the toxitolerant to the air pollution is proved by the authoress.

  1. The Influence of Industrial Air Pollution Forest Lichens at Tomaszów Mazowiecki Region (Central Poland

    Directory of Open Access Journals (Sweden)

    Krystyna Czyżewska

    2014-08-01

    Full Text Available The influence of mixed gases pollution (SO2, H2S and CS2 on epiphytic and epixylic lichens growing on Pinus sylvestris in the nature conditions is the matter of consideration. In the case of some lichens, e.g. Lecanora conizaeoides, Scoliciosporum chlorococcum and Thelocarpon laureri the toxitolerant to the air pollution is proved by the authoress.

  2. Influence of the datasets size on the stability of the LR in the lower region of the within source distribution

    NARCIS (Netherlands)

    Haraksim, Rudolf; Meuwly, Didier

    2013-01-01

    This article focuses on the statistical evaluation of the fingermark evidence using the likelihood ratio (LR) approach. It studies the influence of the quantity of data used to model the within (WS) and between (BS) source variability. The LR system built for the experiment uses an Automated Fingerp

  3. IAEA Director General candidates announced

    International Nuclear Information System (INIS)

    Full text: The IAEA today confirms receipt of the nomination of five candidates for Director General of the IAEA. Nominations of the following individuals have been received by the Chairperson of the IAEA Board of Governors, Ms. Taous Feroukhi: Mr. Jean-Pol Poncelet of Belgium; Mr. Yukiya Amano of Japan; Mr. Ernest Petric of Slovenia; Mr. Abdul Samad Minty of South Africa; and Mr. Luis Echavarri of Spain. The five candidates were nominated in line with a process approved by the Board in October 2008. IAEA Director General Mohamed ElBaradei's term of office expires on 30 November 2009. He has served as Director General since 1997 and has stated that he is not available for a fourth term of office. (IAEA)

  4. VALUE ORIENTATIONS OF TEACHER CANDIDATES

    OpenAIRE

    YAPICI, Asım; KUTLU, M.Oğuz; BİLİCAN, F.Işıl

    2012-01-01

    Abstract This cross-sectional, descriptive study examined the change in values in time among teacher candidates. The Schwartz Values Inventory was administered to 708 freshmen and senior students studying at Cukurova University, Education Faculty. The results have shown that the students at the department of Science Education valued power, achievement, stimulation; the department of English Teaching Education valued hedonism; and the department of Education of Religious Culture valued un...

  5. Comet candidates among quasi-Hilda objects

    Science.gov (United States)

    Gil-Hutton, R.; García-Migani, E.

    2016-05-01

    Aims: We present the results of a search for quasi-Hilda comets. We wanted to find objects that have recently arrived from the Centaur zone that could became active near the perihelion of their orbits. Methods: Two hundred and seventy-seven objects from the ASTORB database were selected following a dynamical criteria to constrain the unstable quasi-Hilda region. These objects were integrated backward 50 000 yr in order to identify those that have recently arrived from the outer regions of the solar system. Results: The backward integration showed that 11 objects could be Centaurs or transneptunian objects that ended their dynamical evolution as quasi-Hilda comets. The dynamical evolution of these objects from a statistical point of view was studied by computing the time-averaged distribution of a number of clones as a function of the aphelion and perihelion distances. All the candidates show a dynamical behavior that is expected for comets injected in the inner solar system from the Centaur or transneptunian regions and reaching the quasi-Hilda region.

  6. The influence of active region information on the prediction of solar flares: an empirical model using data mining

    Directory of Open Access Journals (Sweden)

    M. Núñez

    2005-11-01

    Full Text Available Predicting the occurrence of solar flares is a challenge of great importance for many space weather scientists and users. We introduce a data mining approach, called Behavior Pattern Learning (BPL, for automatically discovering correlations between solar flares and active region data, in order to predict the former. The goal of BPL is to predict the interval of time to the next solar flare and provide a confidence value for the associated prediction. The discovered correlations are described in terms of easy-to-read rules. The results indicate that active region dynamics is essential for predicting solar flares.

  7. Integrating O3 influences on terrestrial processes: photosynthetic and stomatal response data available for regional and global modeling

    OpenAIRE

    D. Lombardozzi; Sparks, J. P.; G. Bonan

    2013-01-01

    Plants have a strong influence on climate by controlling the transfer of carbon dioxide and water between the biosphere and atmosphere during the processes of photosynthesis and transpiration. Chronic exposure to surface ozone (O3) differentially affects photosynthesis and transpiration because it damages stomatal conductance, the common link that controls both processes, in addition to the leaf biochemistry that only affects photosynthesis. Because of the integral role of O...

  8. Tracking quintessence and cold dark matter candidates

    International Nuclear Information System (INIS)

    We study the generation of a kination-dominated phase in the context of a quintessential model with an inverse-power-law potential and a Hubble-induced mass term for the quintessence field. The presence of kination is associated with an oscillating evolution of the quintessence field and the barotropic index. We find that, in sizeable regions of the parameter space, a tracker scaling solution can be reached sufficiently early to alleviate the coincidence problem. Other observational constraints originating from nucleosynthesis, the inflationary scale, the present acceleration of the universe and the dark-energy-density parameter can be also met. The impact of this modified kination-dominated phase on the thermal abundance of cold dark matter candidates is also investigated. We find that: 1. the enhancement of the relic abundance of the WIMPs with respect to the standard paradigm, crucially depends on the hierarchy between the freeze-out temperature and the temperature at which the extrema in the evolution of the quintessence field are encountered, and; 2. the relic abundance of e-WIMPs takes its present value close to the temperature at which the earliest extremum of the evolution of the quintessence field occurs and, as a consequence, both gravitinos and axinos arise as natural cold dark matter candidates. In the case of unstable gravitinos, the gravitino constraint can be satisfied for values of the initial temperature well above those required in the standard cosmology

  9. What makes the difference? Analysing the regional component of the influence of university's structural configuration on its performance

    NARCIS (Netherlands)

    Sánchez-Barrioluengo, Mabel; Benneworth, Paul

    2015-01-01

    There is an increasing interest in the analysis of how universities should maximise their specific regional contribution alongside their traditional teaching and research goals. However, due to the institutional heterogeneity it is necessary to understand the process by which universities create reg

  10. Influence of Tropical Cyclones Period 1970 TO 2010 IN the Region of Bahia de Banderas, Nayarit-Jalisco Mexico

    Science.gov (United States)

    Hernandez, J. M.

    2013-12-01

    This study evaluates the impacts of tropical cyclones (TC) that made landfall in populated areas along the Pacific coast of Mexico, especially in the region of Bahia de Banderas. During the period of 1970-2010 and used a database of international natural disasters to identify impacts. Were more than 13 events during the reporting period, of which 10 are examined more precipitation accumulated and 6 that caused further damage to the affected population in these cases ranged from 5000 to more than 15 000 inhabitants. Strong winds and heavy rainfall in periods of one to three days were associated with property damage and loss of life. The results of the study indicate that excessive accumulations of rain and daily intensity are important factors connected with the occurrence of disasters in densely populated areas. Six of the first 10 Tropical Cyclone associated with major disasters occurred in conditions of El Niño and four neutral conditions. With the analysis of satellite images using GOES-10 in the IDV software maps were obtained in the coastal impacts of Banderas Bay and describes the main features of each meteorological phenomena. In which concludes that no tropical cyclone entered directly to the Banderas Bay region, but its effects were very relevant, taking into account the topography, land use change and the vulnerability of the region. Tropical Cyclones that have affected the region of Bay of Banderas

  11. Influence of age on the prognostic value of mid-regional pro-adrenomedullin in the general population

    NARCIS (Netherlands)

    Brouwers, Frank P.; de Boer, Rudolf A.; van der Harst, Pim; Struck, Joachim; de Jong, Paul E.; de Zeeuw, Dick; Gans, Rijk O.; Gansevoort, Ron T.; Hillege, Hans L.; van Gilst, Wiek H.; Bakker, Stephan J.

    2012-01-01

    Objective Experimental studies have shown that adrenomedullin (ADM) has an important role in circulatory homeostasis. Mid-regional pro-ADM (MR-proADM) is a stable form of ADM. Observational studies found an important association with age, body mass index and kidney function. The aim of this study wa

  12. Influences of subtropical jet and Tibetan Plateau on precipitation pattern in Asia : Insights from regional climate modeling

    NARCIS (Netherlands)

    Sato, Tomonori

    2009-01-01

    Large topographic features, like the Tibetan Plateau (TP) and the Rocky Mountains, have significant impacts on Earth's climate. Numerical experiments were carried out using a regional climate model in order to study the sensitivity of rainfall distribution to the TP's thermal/dynamic effects and mer

  13. Localized occipital region abnormity of infantile EEG and its influence factors%小儿脑电波局限性异常及其影响因素

    Institute of Scientific and Technical Information of China (English)

    刘娟

    2009-01-01

    Objective To explore pediatric EEG in localized region abnormity and influence factors. Methods 51 children with EEG abnormity were retrospectively analyzed. Results In this group,there are 45 children with EEG abnormity in normal situation,and 6 of 51 childrened appear abnormity in induced tests. All the 51 childrened appeal abnormai brain wave in occipital region in varying degree. Conclusion Pediatric occipital region localization abnormal EEG may be hints related to children paroxysmal disorder, Miscellaneous factors can influence children paroxysmal disorder include all kinds of etiology, pathologic physiology signs and symptoms, age and individual variation ect.%目的 探讨小儿脑电波局限性异常及其影响囚素.方法 回顾性分析51例小儿脑电波枕区局限性异常的检查结果.结果 51例小儿脑电图常规描记异常45例,另6例在诱发试验中出现异常.51例患儿均在枕区出现不同程度的异常脑波.结论 小儿局限性枕区脑电波异常提示可能与发作性疾病有一定关系.

  14. The influence of land cover change in the Asian monsoon region on present-day and mid-Holocene climate

    Directory of Open Access Journals (Sweden)

    A. Dallmeyer

    2011-02-01

    Full Text Available Using the general circulation model ECHAM5/JSBACH, we investigate the biogeophysical effect of large-scale afforestation and deforestation in the Asian monsoon domain on present-day and mid-Holocene climate. We demonstrate that the applied land cover change does not only modify the local climate but also change the climate in North Africa and the Middle East via teleconnections. Deforestation in the Asian monsoon domain enhances the rainfall in North Africa. In parts of the Sahara summer precipitation is more than doubled. In contrast, afforestation strongly decreases summer rainfall in the Middle East and even leads to the cessation of the rainfall-activity in some parts of this region.

    Regarding the local climate, deforestation results in a reduction of precipitation and a cooler climate as grass mostly has a higher albedo than forests. However, in the core region of the Asian monsoon the decrease of evaporative cooling in the monsoon season overcompensates this signal and results in a net warming. Afforestation has mainly the opposite effect, although the pattern of change is less clear. It leads to more precipitation in most parts of the Asian monsoon domain and a warmer climate except for the southern regions where a stronger evaporation decreases near-surface temperatures in the monsoon season.

    When prescribing mid-Holocene insolation, the pattern of local precipitation change differs. Afforestation particularly increases monsoon rainfall in the region along the Yellow River which was the settlement area of major prehistoric cultures. In this region, the effect of land cover change on precipitation is half as large as the orbitally-induced precipitation change. Thus, our model results reveal that mid- to late-Holocene land cover change could strongly have contributed to the decreasing Asian monsoon precipitation during the Holocene known from reconstructions.

  15. Influence of Amazonian deforestation on the future evolution of regional surface fluxes, circulation, surface temperature and precipitation

    Science.gov (United States)

    Lejeune, Quentin; Davin, Edouard L.; Guillod, Benoit P.; Seneviratne, Sonia I.

    2015-05-01

    The extent of the Amazon rainforest is projected to drastically decrease in future decades because of land-use changes. Previous climate modelling studies have found that the biogeophysical effects of future Amazonian deforestation will likely increase surface temperatures and reduce precipitation locally. However, the magnitude of these changes and the potential existence of tipping points in the underlying relationships is still highly uncertain. Using a regional climate model at a resolution of about 50 km over the South American continent, we perform four ERA-interim-driven simulations with prescribed land cover maps corresponding to present-day vegetation, two deforestation scenarios for the twenty-first century, and a totally-deforested Amazon case. In response to projected land cover changes for 2100, we find an annual mean surface temperature increase of over the Amazonian region and an annual mean decrease in rainfall of 0.17 mm/day compared to present-day conditions. These estimates reach and 0.22 mm/day in the total-deforestation case. We also compare our results to those from 28 previous (regional and global) climate modelling experiments. We show that the historical development of climate models did not modify the median estimate of the Amazonian climate sensitivity to deforestation, but led to a reduction of its uncertainty. Our results suggest that the biogeophysical effects of deforestation alone are unlikely to lead to a tipping point in the evolution of the regional climate under present-day climate conditions. However, the conducted synthesis of the literature reveals that this behaviour may be model-dependent, and the greenhouse gas-induced climate forcing and biogeochemical feedbacks should also be taken into account to fully assess the future climate of this region.

  16. Polymorphisms in the dopamine receptor 2 gene region influence improvements during working memory training in children and adolescents.

    Science.gov (United States)

    Söderqvist, Stina; Matsson, Hans; Peyrard-Janvid, Myriam; Kere, Juha; Klingberg, Torkel

    2014-01-01

    Studying the effects of cognitive training can lead to finding better treatments, but it can also be a tool for investigating factors important for brain plasticity and acquisition of cognitive skills. In this study, we investigated how single-nucleotide polymorphisms (SNPs) and ratings of intrinsic motivation were associated to interindividual differences in improvement during working memory training. The study included 256 children aged 7-19 years who were genotyped for 13 SNPs within or near eight candidate genes previously implicated in learning: COMT, SLC6A3 (DAT1), DRD4, DRD2, PPP1R1B (DARPP32), MAOA, LMX1A, and BDNF. Ratings on the intrinsic motivation inventory were also available for 156 of these children. All participants performed at least 20 sessions of working memory training, and performance during the training was logged and used as the outcome variable. We found that two SNPs, rs1800497 and rs2283265, located near and within the dopamine receptor 2 (DRD2) gene, respectively, were significantly associated with improvements during training (p intrinsic motivation did not correlate with training outcome. However, we observed both the main effect of genotype at those two loci as well as the interaction between genotypes and ratings of intrinsic motivation (perceived competence). Both SNPs have previously been shown to affect DRD2 receptor density primarily in the BG. Our results suggest that genetic variation is accounting for some interindividual differences in how children acquire cognitive skills and that part of this effect is also seen on intrinsic motivation. Moreover, they suggest that dopamine D2 transmission in the BG is a key factor for cognitive plasticity. PMID:24001007

  17. Comparative Analyses of Physics Candidates Scores in West African and National Examinations Councils

    Science.gov (United States)

    Utibe, Uduak James; Agah, John Joseph

    2015-01-01

    The study is a comparative analysis of physics candidates' scores in West African and National Examinations Councils. It also investigates influence of gender. Results of 480 candidates were randomly selected form three randomly selected Senior Science Colleges using the WASSCE and NECOSSCE computer printout sent to the schools, transformed using…

  18. Candidate genes for behavioural ecology

    NARCIS (Netherlands)

    Fitzpatrick, M.J.; Ben-Sahar, Y.; Smid, H.M.; Vet, L.E.M.; Robinson, G.E.; Sokolowski, M.B.

    2005-01-01

    In spite of millions of years of evolutionary divergence, the conservation of gene function is common across distant lineages. As such, genes that are known to influence behaviour in one organism are likely to influence similar behaviours in other organisms. Recent studies of the evolution of behavi

  19. INFLUENCE OF THE ENVIRONMENT ON THE CONTENT OF ARSENIC IN CULTIVATED SOILS IN ZGORZELEC-BOGATYNIA REGION

    OpenAIRE

    Ewa Kucharczak-Moryl; Andrzej Moryl; Romuald Żmuda

    2014-01-01

    The study was conducted in the area of influence of Mine and Power Plant “Turów” which, through the emission of gaseous and particulate pollutants contribute to soil contamination, among other things by arsenic. The aim of this study was to determine the total content of this metal in samples of anable soils collected in the area of the impact of the above-mentioned emitters. At the same time their grain-size distribution and their physico-chemical properties, as pH and percentage of organic ...

  20. Postnatal Age Influences Hypoglycemia-induced Poly(ADP-ribose) Polymerase-1 Activation in the Brain Regions of Rats

    OpenAIRE

    Rao, Raghavendra; Sperr, Dustin; Ennis, Kathleen; Tran, Phu

    2009-01-01

    Poly(ADP-ribose) polymerase-1 (PARP-1) overactivation plays a significant role in hypoglycemia-induced brain injury in adult rats. To determine the influence of postnatal age on PARP-1 activation, developing and adult male rats were subjected to acute hypoglycemia of equivalent severity and duration. The expression of PARP-1 and its downstream effectors, apoptosis inducing factor (Aifm1), caspase 3 (Casp3), NF-κB (Nfkb1) and bcl-2 (Bcl2), and cellular poly(ADP-ribose) (PAR) polymer expression...

  1. Ionospheric D-region temperature relaxation and its influences on radio signal propagation after solar X-flares occurrence

    Directory of Open Access Journals (Sweden)

    Bajčetić Jovan

    2015-01-01

    Full Text Available In this paper our attention is focused on relations between radio signal propagation characteristics and temperature changes in D-region after solar X-flare occurrence. We present temperature dependencies of electron plasma frequency, the parameter that describes medium conditions for propagation of an electromagnetic wave, and the refractive index which describes how this wave propagates. As an example for quantitative calculations based on obtained theoretical equations we choose the reaction of the D-region to the solar X-flare occurred on May 5th, 2010. The ionospheric modelling is based on the experimental data obtained by low ionosphere observations using very low frequency radio signal. [Projekat Ministarstva nauke Republike Srbije, br. III-44002, 176002, 176004 i br. TR-32030

  2. Characterizing anthropogenic sources of pollution and their influence on regional air quality and meteorology during the VOCALS-REX experiment

    Science.gov (United States)

    Mena-Carrasco, M.; Carmichael, G. R.; Spak, S.; Molina, L. T.; Saide, P.

    2010-12-01

    During the VOCALS REX campaign multiple anthropogenic sources of aerosol (both primary and secondary) were related to small effective radii of cloud droplets observed both in situ, and from satellite sources. Also enhanced concentrations of secondary pollutants such as ozone and sulfate were observed. Some of these sources come from copper smelters, power plants, and large urban areas. These impacts on the properties of marine stratocumulus is relevant on the region's radiative balance. For this project the contribution of urban, industrial, and power sector emissions will be compared to attribute these to observed values using WRF-Chem using a new Chilean National Emissions Inventory developed for this project. Finally regional ozone formation from Santiago and it's impact to observed enhancements off the coast of Northern Chile will be assessed. Modeled plumes will be compared to satellite observations of anthropogenic impacted clouds. Considering the projected increase of coal power plants in northern Chile, some projected impacts will also be shown.

  3. Influence of variable weather on incident solar radiation and its spectral composition in the Ostrava region, Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Opálková, M.; Robson, T. M.; Navrátil, M.; Špunda, Vladimír

    Brno: Global Change Research Centre, The Czech Academy of Sciences, v. v. i., 2015 - (Urban, O.; Šprtová, M.; Klem, K.), s. 38-41 ISBN 978-80-87902-10-3. [Global Change: A Complex Challenge /4th/. Brno (CZ), 23.03.2015-24.03.2015] Institutional support: RVO:67179843 Keywords : weather * solar radiation * Ostrava region Subject RIV: DG - Athmosphere Sciences, Meteorology

  4. The influence of active region information on the prediction of solar flares: an empirical model using data mining

    OpenAIRE

    Núñez, M.; Fidalgo, R.; Baena, M.; R Morales

    2005-01-01

    Predicting the occurrence of solar flares is a challenge of great importance for many space weather scientists and users. We introduce a data mining approach, called Behavior Pattern Learning (BPL), for automatically discovering correlations between solar flares and active region data, in order to predict the former. The goal of BPL is to predict the interval of time to the next solar flare and provide a confidence value for the associated prediction. The discovered correlations are described...

  5. The influence of active region information on the prediction of solar flares: an empirical model using data mining

    OpenAIRE

    Núñez, M.; Fidalgo, R.; Baena, M.; R Morales

    2005-01-01

    Predicting the occurrence of solar flares is a challenge of great importance for many space weather scientists and users. We introduce a data mining approach, called Behavior Pattern Learning (BPL), for automatically discovering correlations between solar flares and active region data, in order to predict the former. The goal of BPL is to predict the interval of time to the next solar flare and provide a confidence value for the associated prediction. The discovered correlat...

  6. The influence of active region information on the prediction of solar flares: an empirical model using data mining

    OpenAIRE

    Núñez, M.; Fidalgo, R.; Baena, M.; Morales, R.

    2005-01-01

    International audience Predicting the occurrence of solar flares is a challenge of great importance for many space weather scientists and users. We introduce a data mining approach, called Behavior Pattern Learning (BPL), for automatically discovering correlations between solar flares and active region data, in order to predict the former. The goal of BPL is to predict the interval of time to the next solar flare and provide a confidence value for the associated prediction. The discovered ...

  7. A model study of factors influencing projected changes in regional sea level over the twenty-first century

    Energy Technology Data Exchange (ETDEWEB)

    Pardaens, Anne K.; Lowe, J.A. [Met Office, Hadley Centre, Exeter, Devon (United Kingdom); Gregory, J.M. [Met Office, Hadley Centre, Exeter, Devon (United Kingdom); University of Reading, Department of Meteorology, Walker Institute for Climate System Research, Earley Gate, PO Box 243, Reading (United Kingdom)

    2011-05-15

    In addition to projected increases in global mean sea level over the 21st century, model simulations suggest there will also be changes in the regional distribution of sea level relative to the global mean. There is a considerable spread in the projected patterns of these changes by current models, as shown by the recent Intergovernmental Panel on Climate Change (IPCC) Fourth Assessment (AR4). This spread has not reduced from that given by the Third Assessment models. Comparison with projections by ensembles of models based on a single structure supports an earlier suggestion that models of similar formulation give more similar patterns of sea level change. Analysing an AR4 ensemble of model projections under a business-as-usual scenario shows that steric changes (associated with subsurface ocean density changes) largely dominate the sea level pattern changes. The relative importance of subsurface temperature or salinity changes in contributing to this differs from region to region and, to an extent, from model-to-model. In general, thermosteric changes give the spatial variations in the Southern Ocean, halosteric changes dominate in the Arctic and strong compensation between thermosteric and halosteric changes characterises the Atlantic. The magnitude of sea level and component changes in the Atlantic appear to be linked to the amount of Atlantic meridional overturning circulation (MOC) weakening. When the MOC weakening is substantial, the Atlantic thermosteric patterns of change arise from a dominant role of ocean advective heat flux changes. (orig.)

  8. Molecular clouds under the influence of massive stars in the Galactic HII region G353.2+0.9

    CERN Document Server

    Giannetti, A; Massi, F; Tieftrunk, A; Beltran, M T

    2011-01-01

    The Galactic HII region G353.2+0.9 is excited by the massive open cluster Pismis-24. By analyzing (sub-)mm molecular-line and -continuum we study the detailed morphology of the gas and dust, as well as their physical parameters and their variation across the PDR. We observed various molecules and transitions to derive the physical properties of the molecular gas through line ratios, and both LTE and non-LTE analyses. The physical properties of the gas were derived with a Bayesian approach for the non-LTE analysis. Based on the continuum data at 870 micron, we derived the dust mass and the column density of H2, and thus the molecular abundances. The total mass of the gas in the region is ca. 2000 Mo, while that of the dust is ca. 21 Mo. A velocity gradient in the region suggests that the expansion of the ionized gas is pushing the molecular gas away from the observer. We unambiguously identify the ionization front, at the location of which we detect an increase in gas density and temperature. We find at least ...

  9. A Study on factors influencing the Nutritional Status of Lactating Women in Jammu, Kashmir and Ladakh Regions.

    Science.gov (United States)

    Khan, Yasmeen Majid; Khan, Asmat

    2012-09-01

    The health of women is linked to their status in the society. The demographic consequence of the women has formed expression in various forms, such as female infanticide, higher death rate, lower sex ratio, low literacy level and lower level of employment of women in the nonagricultural sector as compared to men. Generally, at household level, cultural norms and practices and socio-economic factors determine the extent of nutritional status among women. For the purpose of present investigation, the data collected during 2005-06 on diet and nutritional status of tribal rural and urban lactating women respectively in States of Jammu and Kashmir was utilized. The study revealed inadequate dietary intake, especially micronutrient deficiency (hidden hunger) during lactation. Tribal women were particularly vulnerable to under nutrition compared to women in rural and urban areas. (16.9%) women had chronic energy deficiency, (56.4%) of women from all the three regions were observed to have clinical signs of nutritional deficiency, (30% )of women had taken deficient calories Clinical signs of deficiency of nutrition were uniformly distributed among three regions (p> 0.01), whereas indicators like BMI and caloric intake showed significant difference (P< 0.01) between the three regions . 49% studied women were found to be anemic.

  10. Short term influence of mechanical factors on regional musculoskeletal pain: a study of new workers from 12 occupational groups

    OpenAIRE

    Nahit, E; Macfarlane, G; Pritchard, C; Cherry, N; Silman, A

    2001-01-01

    OBJECTIVES—To determine the influence of short term exposure to mechanical factors on regional musculoskeletal pain.
METHODS—Full time newly employed workers were recruited from 12 occupational groups and information collected by questionnaire. Subjects indicated on a blank body manikin any low back, shoulder, wrist or forearm or both, or knee pain which had occurred during the past month and had lasted more than 1 day. Data were also collected with a previously validated questionnaire on wor...

  11. Relaxor type perovskites: Primary candidates of nano-polar regions

    Indian Academy of Sciences (India)

    S B Krupanidhi

    2003-10-01

    Relaxor properties of 0.7Pb(Mg1/3Nb2/3)O3-0.3PbTiO3 (PMN-PT) and non-lead perovskite thin films have been analysed in terms of large frequency dispersion of dielectric response at low temperatures. A wide spectrum of dielectric relaxation was observed in the frequency-dependent response of the imaginary part of the dielectric permittivity. Transformation from normal ferroelectric to relaxor behaviour has been observed in the case of the Ca substituting the BaTiO3 thin films. A number of techniques were exploited to investigate the wide spectrum of relaxation times in pulsed laser ablated thin films. and electric field induced complex dielectric properties of 0.7Pb(Mg1/3Nb2/3)O3-0.3PbTiO3 (PMN-PT) thin films were studied as function of frequencies at different temperatures. Nonlinear behaviour of dielectric susceptibility with respect to the amplitude of the drive was observed at lower temperatures. The frequency dependence of transition temperature (temperature of the maximum of dielectric constant) was studied using the Vogel-Fulcher relation.

  12. Using microarrays to identify positional candidate genes for QTL: the case study of ACTH response in pigs

    DEFF Research Database (Denmark)

    Jouffe, Vincent; Rowe, Suzanne; Liaubet, Laurence;

    2009-01-01

    Background: Microarray studies can supplement QTL studies by suggesting potential candidate. Microarray studies can supplement QTL studies by suggesting potential candidate genes in the QTL regions, which by themselves are too large to provide a limited selection of candidate genes. Here we provi...

  13. Dark matter candidates and methods for detecting them

    Science.gov (United States)

    Raffelt, G. G.

    1992-01-01

    A number of experiments employing Ge and Si ionization detectors have excluded large regions in the plane of masses and scattering cross-sections for weakly-interacting dark matter (DM) candidates. It is judged that, before a realistic detection experiment for supersymmetric DM candidates can be conducted, significant development efforts will have to be completed for suitable cryogenic or ionization detectors. Pilot experiments have demonstrated the feasibility of axion searches with microwave cavities, but these are at least two orders of magnitude too low in sensitivity.

  14. Promising new cryogenic seal candidate

    International Nuclear Information System (INIS)

    Of the five seal candidates considered for the main propellant system of the Space Shuttle, only one candidate, the fluoroplastic Halar, satisfied all tests including the critical LO2 impact test and the cryogenic compression sealability test. Radiation-cross-linked Halar is a tough, strong thermoplastic that not only endured one hundred 2200 N compression cycles at 83 K while mounted in a standard military O-ring gland without cracking or deforming, but improved in sealability as a result of this cycling. Although these Halar O-rings require much higher sealing forces (approximately 500 N) at room temperature than rubber O-rings, on cooling to cryogenic temperatures the required sealing force only doubles, whereas the sealing force for rubber O-rings increases eightfold. Although these Halar O-rings were inadequately cross-linked, they still exhibited promise as LO2-compatible cryogenic seals. It is expected that their high-temperature properties can be greatly improved by higher degrees of cross-linking (e.g., by 20 mrad of radiation) without compromising their already excellent low-temperature properties. A direct comparison should then be obtained between the best of the cross-linked Halar compounds and the current commercial cryogenic seal materials, filled Teflon and Kel-F

  15. The spatial distribution of esophageal and gastric cancer in Caspian region of Iran: An ecological analysis of diet and socio-economic influences

    Directory of Open Access Journals (Sweden)

    Mahmoodi Mahmood

    2011-02-01

    Full Text Available Abstract Recent studies have suggested a systematic geographic pattern of esophageal cancer (EC and gastric cancer (GC incidence in the Caspian region of Iran. The aims of this study were to investigate the association between these cancers and the region's dietary and socioeconomic risk factors and to map EC and GC after adjustment for the risk factors and the removal of random and geographic variations from area specific age standardised incidence ratios (SIRs. We obtained cancer data from the Babol cancer registry from 2001 to 2005, socioeconomic indices from the Statistical Centre of Iran, and dietary patterns from the control group in a case control study conducted in the study region. Regression models were fitted to identify significant covariates, and clusters of elevated rates were identified. We found evidence of systematic clustering for EC and GC in men and women and both sexes combined. EC and GC SIRs were lower in urban areas, and were also lower in areas of high income. EC SIRs were lower in areas with higher proportions of people having unrestricted food choice and higher in areas with higher proportions of people with restricted food choice. EC and GC were associated with aggregated risk factors, including income, urbanisation, and dietary patterns. These variables represent the influence of improved lifestyle which has coincided with a decrease in upper gastrointestinal cancer frequency over recent decades but which has not necessarily been uniform throughout the region.

  16. Influence of promoter/enhancer region haplotypes on MGMT transcriptional regulation: a potential biomarker for human sensitivity to alkylating agents

    Science.gov (United States)

    Abdel-Rahman, Sherif Z.

    2014-01-01

    The O 6-methylguanine-DNA methyltransferase gene (MGMT) encodes the direct reversal DNA repair protein that removes alkyl adducts from the O 6 position of guanine. Several single-nucleotide polymorphisms (SNPs) exist in the MGMT promoter/enhancer (P/E) region. However, the haplotype structure encompassing these SNPs and their functional/biological significance are currently unknown. We hypothesized that MGMT P/E haplotypes, rather than individual SNPs, alter MGMT transcription and can thus alter human sensitivity to alkylating agents. To identify the haplotype structure encompassing the MGMT P/E region SNPs, we sequenced 104 DNA samples from healthy individuals and inferred the haplotypes using the data generated. We identified eight SNPs in this region, namely T7C (rs180989103), T135G (rs1711646), G290A (rs61859810), C485A (rs1625649), C575A (rs113813075), G666A (rs34180180), C777A (rs34138162) and C1099T (rs16906252). Phylogenetics and Sequence Evolution analysis predicted 21 potential haplotypes that encompass these SNPs ranging in frequencies from 0.000048 to 0.39. Of these, 10 were identified in our study population as 20 paired haplotype combinations. To determine the functional significance of these haplotypes, luciferase reporter constructs representing these haplotypes were transfected into glioblastoma cells and their effect on MGMT promoter activity was determined. Compared with the most common (reference) haplotype 1, seven haplotypes significantly upregulated MGMT promoter activity (18–119% increase; P < 0.05), six significantly downregulated MGMT promoter activity (29–97% decrease; P < 0.05) and one haplotype had no effect. Mechanistic studies conducted support the conclusion that MGMT P/E haplotypes, rather than individual SNPs, differentially regulate MGMT transcription and could thus play a significant role in human sensitivity to environmental and therapeutic alkylating agents. PMID:24163400

  17. Regional patterns and local variability of dry and occult deposition strongly influence sulfate concentrations in Maine lakes

    International Nuclear Information System (INIS)

    There is great uncertainty and large cost in making dry deposition measurements. The authors present evidence based on wet deposition, evapotranspiration, S storage in lake sediments, and sulfate concentrations in lakes and streams in Maine that the dry deposition flux of sulfur to drainage basins of lakes in Maine ranges from nearly 0% to more than 100% of wet deposition, even in small areas. The regional pattern of sulfate concentrations in Maine lakes is due to gradients in both wet and dry deposition and variation in evapotranspiration. Patterns are modified locally by lakes hydrologic type, elevation, vegetation, and terrestrial drainage basin aspect. (Copyright (c) 1988 Elsevier Science Publishers B.V.)

  18. Atmospheric circulation in regional climate models over Central Europe: links to surface air temperature and the influence of driving data

    Czech Academy of Sciences Publication Activity Database

    Plavcová, Eva; Kyselý, Jan

    2012-01-01

    Roč. 39, 7-8 (2012), s. 1681-1695. ISSN 0930-7575 R&D Projects: GA ČR GAP209/10/2265 Grant ostatní: ENSEMBLES: EU-FP6(XE) 505539 Institutional support: RVO:68378289 Keywords : Regional climate models * Global climate models * Atmospheric circulation * Surface air temperature * ENSEMBLES * Central Europe Subject RIV: DG - Athmosphere Sciences, Meteorology Impact factor: 4.231, year: 2012 http://link.springer.com/article/10.1007%2Fs00382-011-1278-8#

  19. Ellen Rehm. The Classification of Objects from the Black Sea Region Made or Influenced by the Achaemenids

    OpenAIRE

    Nunn, Astrid

    2016-01-01

    Que veut dire influence dans un art achéménide si éclectique ? L’A. part des caractéristiques les plus locales et se rapproche en trois étapes de l’art du centre achéménide. Les noms qu’elle a choisis pour ces trois étapes – « court-style art » (« Hofstil »), « satrapal art » et « Perso-barbarian art » – sont expressément « catchy » pour permettre une référence rapide. L’A. en livre un historique et il va sans dire qu’il n’est pas toujours facile de ranger les objets dans l’une ou l’autre cat...

  20. Newborn regional body composition is influenced by maternal obesity, gestational weight gain and the birthweight standard score

    DEFF Research Database (Denmark)

    Carlsen, Emma Malchau; Renault, Kristina Martha; Nørgaard, K.;

    2014-01-01

    obese and 80 normal weight mothers and their newborn infants and assessed the babies' body composition using dual-energy X-ray absorptiometry. RESULTS: The total and abdominal fat masses of infants born to mother who were obese before pregnancy were 135 g (p < 0.001) and 18 g (p < 0.001) higher than the...... offspring of normal weight mothers. The infants' fat mass increased by 11 g (p < 0.001) for every kilogram of GWG. There were no associations between prepregnancy obesity and fat-free mass. The fat percentage was significantly higher in infants who were large for gestational age (15.3%) than small for......AIM: This study investigated whether newborn body composition is influenced by prepregnancy obesity and gestational weight gain (GWG) and explored any associations between body composition and birthweight standard score (z-score), categorised by size for gestational age. METHODS: We recruited 231...

  1. Factors influencing integration of TB services in general hospitals in two regions of China: a qualitative study

    Directory of Open Access Journals (Sweden)

    Zou Guanyang

    2012-01-01

    Full Text Available Abstract Background In the majority of China, the Centre for Disease Control (CDC at the county level provides both clinical and public health care for TB cases, with hospitals and other health facilities referring suspected TB cases to the CDC. In recent years, an integrated model has emerged, where the CDC remains the basic management unit for TB control, while a general hospital is designated to provide clinical care for TB patients. This study aims to explore the factors that influence the integration of TB services in general hospitals and generate knowledge to aid the scale-up of integration of TB services in China. Methods This study adopted a qualitative approach using interviews from sites in East and West China. Analysis was conducted using a thematic framework approach. Results The more prosperous site in East China was more coordinated and thus had a better method of resource allocation and more patient-orientated service, compared with the poorer site in the West. The development of public health organizations appeared to influence how effectively integration occurred. An understanding from staff that hospitals had better capacity to treat TB patients than CDCs was a strong rationale for integration. However, the economic and political interests might act as a barrier to effective integration. Both sites shared the same challenges of attracting and retaining a skilled workforce for the TB services. The role of the health bureau was more directive in the Western site, while a more participatory and collaborative approach was adopted in the Eastern site. Conclusion The process of integration identifies similarities and differences between sites in more affluent East China and poorer West China. Integration of TB services in the hospitals needs to address the challenges of stakeholder motivations and resource allocation. Effective inter-organizational collaboration could help to improve the efficiency and quality of TB service. Key

  2. Influence of string-like cooperative atomic motion on surface diffusion in the (110) interfacial region of crystalline Ni

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Hao, E-mail: hao.zhang@ualberta.ca, E-mail: jack.douglas@nist.gov; Yang, Ying [Department of Chemical and Materials Engineering, University of Alberta, Alberta T6G 2V4 (Canada); Douglas, Jack F., E-mail: hao.zhang@ualberta.ca, E-mail: jack.douglas@nist.gov [Materials Science and Engineering Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899 (United States)

    2015-02-28

    Although we often think about crystalline materials in terms of highly organized arrays of atoms, molecules, or even colloidal particles, many of the important properties of this diverse class of materials relating to their catalytic behavior, thermodynamic stability, and mechanical properties derive from the dynamics and thermodynamics of their interfacial regions, which we find they have a dynamics more like glass-forming (GF) liquids than crystals at elevated temperatures. This is a general problem arising in any attempt to model the properties of naturally occurring crystalline materials since many aspects of the dynamics of glass-forming liquids remain mysterious. We examine the nature of this phenomenon in the “simple” case of the (110) interface of crystalline Ni, based on a standard embedded-atom model potential, and we then quantify the collective dynamics in this interfacial region using newly developed methods for characterizing the cooperative dynamics of glass-forming liquids. As in our former studies of the interfacial dynamics of grain-boundaries and the interfacial dynamics of crystalline Ni nanoparticles (NPs), we find that the interface of bulk crystalline Ni exhibits all the characteristics of glass-forming materials, even at temperatures well below the equilibrium crystal melting temperature, T{sub m}. This perspective offers a new approach to modeling and engineering the properties of crystalline materials.

  3. Influence of string-like cooperative atomic motion on surface diffusion in the (110) interfacial region of crystalline Ni

    International Nuclear Information System (INIS)

    Although we often think about crystalline materials in terms of highly organized arrays of atoms, molecules, or even colloidal particles, many of the important properties of this diverse class of materials relating to their catalytic behavior, thermodynamic stability, and mechanical properties derive from the dynamics and thermodynamics of their interfacial regions, which we find they have a dynamics more like glass-forming (GF) liquids than crystals at elevated temperatures. This is a general problem arising in any attempt to model the properties of naturally occurring crystalline materials since many aspects of the dynamics of glass-forming liquids remain mysterious. We examine the nature of this phenomenon in the “simple” case of the (110) interface of crystalline Ni, based on a standard embedded-atom model potential, and we then quantify the collective dynamics in this interfacial region using newly developed methods for characterizing the cooperative dynamics of glass-forming liquids. As in our former studies of the interfacial dynamics of grain-boundaries and the interfacial dynamics of crystalline Ni nanoparticles (NPs), we find that the interface of bulk crystalline Ni exhibits all the characteristics of glass-forming materials, even at temperatures well below the equilibrium crystal melting temperature, Tm. This perspective offers a new approach to modeling and engineering the properties of crystalline materials

  4. On small climatic effects of air invasion in polar regions: The influence on atmospheric pressure and heat flux

    International Nuclear Information System (INIS)

    The possibility of decreasing atmospheric pressure by air invasion in the down-welling zone of the ocean is discussed. The boundary condition for the solution of the baric tendency equation on the atmosphere-ocean interface is derived. It is shown that atmospheric pressure may decrease about 0.1-10 Pa day-1 for gas invasion and downwelling rates of 0.001-0.1 cm c-1, due to active gas-water exchange without regard for heat and water vapor transfer. This calculation was based on a model of the diffusion boundary layer. It was used for the total solution of the baric tendency equation. These estimates were made for the region of formation of Antarctic Bottom Water. This factor, with regard to the quasi-stationary condition of the process, provides a significant contribution to the formation of atmospheric depressions, sub-antarctic depressions and some depressions in high latitudes of both hemispheres. The heat effect of N2, O2 and CO2 solutions in polar sea regions is considered. It is shown that, for example, the heat flux with CO2 solution (∼20 mol m-2 yr-1) corresponds to 12 Cal cm-2 year. This flux and the flux from the earth's interior (∼47 Cal cm-2 yr-1) are the same order of magnitude. In winter, this factor is one positive member of the heat balance for the polar surface layers

  5. The influence of land use on the concentration and vertical distribution of PBDEs in soils of an e-waste recycling region of South China

    International Nuclear Information System (INIS)

    The vertical distribution of polybrominated diphenyl ethers (PBDEs) in soil at four sites within an e-waste recycling region of South China was investigated. PBDE concentrations in soil ranged from 1.38 to 765 ng/g. There was a trend of decreasing PBDE concentration with soil depth, especially in the paddy field. However, high concentrations of BDE-209 were found in deeper soils indicating a highly preferential migration. There was a stronger correlation between PBDEs and total organic carbon (TOC), compared to dissolved organic carbon (DOC), which suggests that the association between non-dissolved organic carbon (NDOC) and PBDEs is stronger than for DOC. Different land use types, in particular differences in farming activities, significantly influenced the vertical distribution of PBDEs in soils. PBDEs displayed a higher leaching tendency in moist paddy soil than in drier soils. The frequent flooding condition in paddy field may facilitate the vertical transfer of PBDEs to the deeper soils. - Highlights: • Vertical distributions of PBDEs in soil cores of e-waste sites were investigated. • Non-dissolved organic carbon may have high impact on the retention of PBDEs. • Farming patterns can significantly influence soil vertical distribution of PBDEs. • Leaching tendency of PBDEs in paddy field was higher than in dry land. - Different farming activities can influence the vertical distribution of PBDEs in soil, as the leaching tendency of PBDEs was greater in moist paddy soil than in drier soils

  6. The use of genetic bioassays to evaluate the environmental quality in a region under the influence of urban waste in Guaíba lake basin (Brazil

    Directory of Open Access Journals (Sweden)

    Izabel Vianna Villela

    2013-06-01

    Full Text Available The mussel species Limnoperna fortunei was chosen as biomonitoring organism in Guaíba Lake Basin, based on population data, distribution, and sensitivity. Previous in vitro and in vivo studies studies with Single Cell Gel Assay (SCGA and Micronuclei test (MN on this freshwater mussel showed that it is successful in biomonitoring studies, especially in urban pollution monitoring. This study evaluated two sampling sites in the Guaíba Lake (Guaíba PC e Guaíba BR, near urban waste discharges, and a control site (Itapuã insight a preserved area, using L. fortunei individuals. Comparing to the control site, the Guaíba BR sample induced DNA damage in haemocytes of mussels sampled both in situ and exposed to laboratory conditions, whereas MN only in in situ collected mussels. This sample also presented the only surface water mutagenic result by Salmonella/microsome assay with TA98 in the presence of metabolic activation. Guaíba PC samples increased MN frequency in situ and in laboratory conditions comparing to the Itapuã results. Metal influence seems to be less important than organic influence in genotoxic induction. These results confirm the strong urban influence in this region, showing that biomonitoring is a powerful tool to detect this kind of contamination in water bodies.

  7. Child marriage prevention in Amhara Region, Ethiopia: association of communication exposure and social influence with parents/guardians' knowledge and attitudes.

    Science.gov (United States)

    Gage, Anastasia J

    2013-11-01

    Despite increasing international attention to child marriage and its negative health and social consequences, little is known about the knowledge and beliefs of individuals who are in control of negotiating children's marriages and of the social context in which these individuals function. Using data from a 2007 cross-sectional household survey and multilevel logistic regression models, this paper examined the associations of communication exposure and measures of social influence with knowledge of marriage legislation, perceptions that marriage before age 18 was "too early", and beliefs in daughters' rights to individual marriage choice among parents/guardians in Amhara Region, Ethiopia. The study found that mass media and interpersonal communication exposure were positively associated with all outcomes. The influence of communication exposure on knowledge of the legal minimum age at marriage and the perception that marriage before 18 was "too early" varied significantly across communities. Community pressure to stop child marriages and awareness of marriage law enforcement were positively associated with endorsing daughters' rights to choose their marriage age and partner. Perceived social norms regarding early marriage, normative beliefs and perceived benefits of delayed marriage were at least as important as communication exposure for endorsing daughters' rights to marriage choice. Gender and education differences were detected. The findings imply that child marriage-prevention programs should diversify information channels, reinforce perceived advantages of delayed marriage, and adopt a social influence perspective. PMID:24161097

  8. The relative influence of local and regional environmental drivers of algal biomass (chlorophyll-a) varies by estuarine location

    Science.gov (United States)

    Wainger, Lisa; Yu, Hao; Gazenski, Kim; Boynton, Walter

    2016-09-01

    A major question in restoring estuarine water quality is whether local actions to manage excess nutrients can be effective, given that estuaries are also responding to tidal inputs from adjacent water bodies. Several types of statistical analysis were used to examine spatially-detailed and long-term water quality monitoring data in eight sub-estuaries of Chesapeake Bay. These sub-estuaries are likely to be similar to other shallow systems with moderate to long water residence times. Statistical cluster analysis of spatial water quality data suggested that estuaries had spatially distinct water quality zones and that the peak algal biomass (as measured by chlorophyll-a) was most often controlled by local watershed inputs in all but one estuary, although mainstem inputs affected most estuaries at some times and places. An elasticity indicator that compared inter-annual changes in sub-estuaries to parallel changes in the mainstem Chesapeake Bay supported the idea that water quality in sub-estuaries was not strongly coupled to the mainstem. A cross-channel zonation of water quality observed near the mouth of estuaries suggested that Bay influences were stronger on the right side of the lower channel (looking up estuary) at times in all estuaries, and was most common in small estuaries closest to the mouth of the primary water source to the estuary. Where Bay influences were strong, estuarine water quality would be expected to be less responsive to nutrient reductions made in the local watershed. Regression analysis was used to evaluate hypothesized relationships between environmental driver variables and average chlorophyll-a (chl-a) concentrations. Chl-a values were calculated from unusually detailed levels of spatial sampling, potentially providing a more comprehensive view of system conditions than that provided by traditional sparse sampling networks. The univariate models with the best data support to explain variability in averaged chl-a concentration were those

  9. Influence of the existing tariff system and regional tariff systems to the operation of HPP St. Petka and HPP Matka

    International Nuclear Information System (INIS)

    The reservoir of HPP Sveta Petka and HPP Matka is much smaller then the reservoir of HPP Kozjak. In order to achieve as efficient as possible operation of their available water, the levels of their reservoirs might have wide range oscillations. These oscillations of the reservoir levels, in some cases, may have negative influence on the environment. The main objective of this paper is to estimate the range of the daily oscillations of the reservoirs' levels in case of HPP Sveta Petka and HPP Matka, depending on the operation modes of all three HPP on the river Treska. For the purposes of achieving the aforementioned objective, wide range of calculations is performed, according two methods: one which is based on non-linear programming and the other on dynamic programming. It should be noted that the purpose of the study is not to provide results which could be directly used as they are presented (part of the input data is estimated for the purpose of the study), but mainly to illustrate the effectiveness of the above mentioned methods for performing calculations of this nature. The results based on real input data could be used as a base for ecological analyses and studies, in order to estimate the influence of these oscillations on the environment, as well as to identify the possible needs of adjustment of the power plants' operation mode with the environmental requirements. The conclusion is that the frequency of occurrence of operational levels below the elevation of 313.5 m.a.S.L in the 'Matka' reservoir, i.e. below the threshold elevation of the water tail of HPP 'Sveta Petka', is the lowest when HPP 'Sveta Petlka' and HPP 'Matka' are in operation according to the maximum income criterion (Variant A). In this particular case, HPP 'Matka' follows up the operation of HPP 'Sveta Petka' and there is a reduced necessity for re-regulation of the waters and for decreasing its reservoir elevation. In the Variants C and D, the reservoir elevation in HPP 'Matka' would

  10. Influence of the Leader protein coding region of foot-and-mouth disease virus on virus replication

    DEFF Research Database (Denmark)

    Belsham, Graham

    2013-01-01

    The foot-and-mouth disease virus (FMDV) Leader (L) protein is produced in two forms, Lab and Lb, differing only at their amino-termini, due to the use of separate initiation codons, usually 84 nt apart. It has been shown previously, and confirmed here, that precise deletion of the Lab coding......, in the context of the virus lacking the Lb coding region, was also tolerated by the virus within BHK cells. However, precise loss of the Lb coding sequence alone blocked FMDV replication in primary bovine thyroid cells. Thus, the requirement for the Leader protein coding sequences is highly dependent...... on the nature and extent of the residual Leader protein sequences and on the host cell system used. FMDVs precisely lacking Lb and with the Lab initiation codon modified may represent safer seed viruses for vaccine production....

  11. Iran and Syria, a changing foreign policy. A comparative analysis of their internal links and influence regions.

    Directory of Open Access Journals (Sweden)

    Marcela Guerrero Turbay

    2013-06-01

    Full Text Available In recent years there have been changes in the foreign policy of Syria and Iran, showing how their goals are far from immutable. Typically they have been associated and in some circles they talk of an alliance. However, this paper aims to show that although there is a convergence in a number of issues, their foreign policy priorities put them away. For this, the text is divided into two parts. First, there is a comparison of the internal links that condition the foreign policy in each state. Secondly, regional (and global? projection of the two nations is contrasted. Throughout the document, the notion of James Rosenau´s comparative study of foreign policy will be taken as a reference.

  12. Influence of Punica granatum L. on region specific responses in rat brain during Alloxan-Induced diabetes

    Institute of Scientific and Technical Information of China (English)

    Sushil Kumar Middha; Talambedu Usha; Tekupalli RaviKiran

    2012-01-01

    Objective: The present study was carried out to investigate the effects of Punica granatum peel methanolic extract (PGPE) on cerebral cortex (CC) and Hippocampus (HC) brain antioxidant defense system and markers of lipid and protein oxidation in alloxan induced diabetic rats.Methods:Oral administration of PGPE (75 and 150 mg of kg body weight) for 45 days resulted in significant reduction in blood glucose levels. Results: Supplementation of diabetic rats with PGPE showed increased activities of SOD and GPx with concomitant decrease in MDA and PC content. Region-specific changes were more evident in the HC when compared to CC. Conclusions: The present study indicated that PGPE can ameliorate brain oxidative stress in alloxan induced diabetic rats by up regulating antioxidant defense mechanism by attenuating lipid and protein oxidation. PGPE thus may be used as a potential therapeutic agent in preventing diabetic complications in the brain.

  13. Influence of uranium and thorium in the natural radioactivity in shales from the middle Amazon river region

    International Nuclear Information System (INIS)

    The feasibility of using the fission track registration technique in the determination of the uranium and thorium content in shales from the middle Amazon river region is studied. The above technique permits, through the determination of the uranium concentration, to establish a correlation between the uranium content and the organic matter present in the shale. In establishing the ratio between the fission tracks due to 238U and 235U, the sample was contaminated with natural uranium and analized, so that no modifications on the analysis conditions might change or distort the results. The experimental results were satisfactory and they may contribute to the study of the industrial exploration of these energy sources as well as to the analysis of problems related to environmental control. (Author)

  14. Understanding environmental and climatic influences on regional differences and spatio-temporalscale issues of dengue fever transmission in Puerto Rico

    Science.gov (United States)

    Serman, E. A.; Akanda, A. S. S.; Ginsberg, H. S.; Couret, J.

    2015-12-01

    Each year, there are an estimated 50-100 million cases of dengue fever worldwide, roughly 30 times the number of cases as 50 years ago, with some estimates even higher. Puerto Rico (PR) has experienced epidemic dengue activity since 1963, and the disease is currently endemic. Since 1990 there have been 4 large epidemics, the most recent in 2010 where there were nearly 27,000 cases reported, amounting to almost 1% of the island's total population. Because no vaccine is currently available, effective control is dependent on our ability to understand the complex relationship between environmental factors, mosquito vector ecology, and disease epidemiology. Dengue virus is transmitted primarily by Aedes aegypti mosquitoes, as humans are the preferred host for Ae. aegypti. The purpose of our analysis is to assess temporal and spatial patterns of dengue transmission in PR and relate this to both climatic and anthropogenic factors. Unlike past studies, which have used San Juan to represent the island as a whole, our research will investigate regional dynamics in dengue transmission, as preliminary results have shown significant differences in population density, disease incidence, and environmental and climatic variables. Data from the Passive Dengue Surveillance System of CDC, meteorological observations from NCDC, and remote sensing data from USGS and NASA will be used together to identify relationships between climate, urbanization, and dengue incidence for PR at various spatial and temporal scales. Preliminary climatic factors considered include precipitation, temperature, humidity, and soil moisture. Finally, we will assess measures of urbanization such as land cover, land use, population density, and infrastructure that can make regional differences in dengue incidence each year. Results from this study could help create early warning systems for dengue surveillance in Puerto Rico, and develop techniques that can be applied to other areas of the world.

  15. Environmental Determinants Influencing Fish Community Structure and Diversity in Two Distinct Seasons among Wetlands of Northern Region (Ghana

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    Collins Ayine Nsor

    2016-01-01

    Full Text Available Fish community structure was assessed in six wetlands using cast nets, to correlate with environmental variables with diversity and distribution patterns, from 2010 to 2012. A total of 2,239 individuals belonging to 44 species and 1,938 individuals belonging to 40 species were sampled in the dry and wet seasons. Mochokid and Mormyrid families dominated fish community and constituted 14.8%, respectively, followed by Alestids (12.9% and Chlariids (11.1%. Rarer taxons were centropomids, channids, malapteruds, and oesteoglossids and represented 1.9%, respectively. Overall, CPUE per net did not vary significantly (Tukey HSD test, p=0.27 in the dry and wet seasons. Wuntori marsh consistently showed dominance in mean monthly CPUE per net (dry = 115±4.5; wet = 107±7.7 seasons, while Bunglung constructed wetland was the least recorded (dry = 56.5±6.2; wet = 58.3±4.1 seasons. Fish diversity and richness differed significantly (F=0.11, p=0.03 among seasons. Environmental disturbances were season-specific and did not differ significantly (F=0.16, df=14, p=0.97 among sites. A DCA ordination explained 69% variability in fish distribution patterns, while PCA showed that 81.8% of nitrate-nitrogen, phosphate, and grazing intensity on axis 1 and conductivity, temperature, and turbidity on axis 2 influenced fish community structure. Wetland conservation must be promoted to sustain fish abundance and overall ecosystem stability.

  16. Confianza, influencia política e intercambio de recursos en arenas decisorias regionales Trust, Political Influence, and Exchange of Resources in Regional Decision-Making Arenas

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    RAMIRO BERARDO

    2012-01-01

    Full Text Available La literatura politológica destaca la importancia de la confianza en la emergencia de procesos sociopolíticos cooperativos, pero en la politología latinoamericana no existen aún exploraciones empíricas de la relación entre confianza y otras variables que también afectan la cooperación en arenas decisorias regionales. Este artículo contribuye a solucionar esta limitación examinando la relación entre confianza, intercambio de recursos y reconocimiento de influencia política, entre actores de tres regiones subnacionales de la Argentina. Los resultados sugieren que tanto el reconocimiento de influencia como el intercambio de recursos se correlacionan de manera muy significativa con las relaciones de confianza que existe entre los actores. Esta relación tiene implicancias sobre procesos de gobernanza a nivel regional, que discutimos en detalle.Research in political science has identified trust as an important variable for the emergence of cooperative social-political processes, but there are no empirical explorations in Latin American political science yet of the relationship between trust and other variables that are thought to affect cooperation in regional decision-making arenas. This article contributes to addressing this limitation by examining the relationship between trust, exchange of resources, and perception of political influence among actors in 3 sub-national regions in Argentina. Results suggest that these variables are significantly related to each other, which has implications for our understanding of how regional governance processes work. We discuss these implications in detail.

  17. Formation, Excitation and Destruction of CH+ under the Influence of Water and Irradiation in Star Forming Regions

    Science.gov (United States)

    Benz, Arnold O.; Simon, Bruderer; van Dishoeck, Ewine

    2015-08-01

    Simple ionized hydrides were observed for the first time with Herschel/HIFI towards young star-forming objects of low to high mass. Of particular interest is CH+, a fundamental precursor molecule for carbon hydrides. Gaseous H2O reduces the abundance of C and C+, the starting products of CH+. The abundances of H2O and CH+ cannot be enhanced at the same place. Strong irradiation by FUV or X-rays reduces H2O, and CH+ gets more abundant. Thus CH+ signals high irradiation, but low H2O abundance.CH+ was observed to be enhanced in most objects to an abundance of typically 10-10 relative to hydrogen. This suggests an internal source of irradiation. The observed ratio of CH+/OH+ is consistent with irradiation by far UV as expected from chemical modelling. For low-mass objects the required FUV flux is between 1 - 200 times the ISRF at the location of the molecules. If the FUV flux originates at the central protostar, an FUV luminosity up to 1.5 Lsun is required. The UV flux in two high-mass objects is 30 and 90 times the ISRF using absorption lines, and of the order of 500 ISRF using emission lines. It is smaller than the unattenuated flux expected from the central object(s). The observed CH+/OH+ ratio, and other ratios such as OH+/H2O+ and CH+/C+, can only be modelled for low molecular hydrogen densities.The targeted lines of CH+, OH+, H2O+, and C+ are detected mostly in blue-shifted absorption. They are proposed to origin in FUV irradiated cavity walls that are shocked by the disk wind. The shock region is turbulent, broadening the lines to some 1 - 12 km/s. It is driven by the outward motion of the wind to blue shifts of 0 to -10 km/s. The blue-shifted H2O emission line (Kristensen et al. 2013) may be related but not coincident with the CH+ emitting region.

  18. Influence of household biogas digester use on household energy consumption in a semi-arid rural region of northwest China

    International Nuclear Information System (INIS)

    Highlights: ► Rural household energy mainly derives from available biomass resources. ► Household energy consumption structure experiencing substantial transformation. ► Biogas energy plays an important roles in rural household energy consumption. ► Biogas digester construction has a profound implication for applied energy. -- Abstract: A comprehensive investigation was conducted to evaluate the efficiency of newly installed biogas digesters in saving biomass resources and addressing energy squandering. Compared with traditional coal-based or firewood dominated energy consumption, the biogas digesters economize on energy resources due to higher heat efficiency. Furthermore, since crop residues of straw and other domestic animal and human excreta are effectively recycled and reused as anaerobic fermentation materials of biogas digesters, greenhouse gas emissions are significantly reduced by converting the previous extensive combustion of such into a sustainable and highly efficient practice in the rural region. The results in this study show that total energy consumption is 412 kgce (kgce: 1 kg standard coal. 1 kgce = 29.31 MJ) in Xiyang Township in 2009. The construction of biogas digesters significantly contributes to the transformation of rural household energy consumption structure, though biogas as a renewable energy only accounts for 6.31% of the total household energy consumption. Per capita rural household energy consumption is 393.07 kgce in household with biogas digesters and 437.60 kgce in household without biogas digesters. In addition, application of biogas dregs, slurry, and marsh liquid to the agricultural crops have greatly reduced the expenditure of buying chemical fertilizers. The average commercial fertilizer per mu (0.067 ha) in rural households using biogas digesters is 12.43 kg and the cost per mu is 29.53 yuan (1 yuan = 0.1523 dollar), while rural households without biogas digesters use 25.22 kg of commercial fertilizers and cost 59

  19. Overheating risk assessment of naturally ventilated classroom under the influence of climate change in hot and humid region

    Science.gov (United States)

    Huang, Kuo-Tsang

    2013-04-01

    Natural ventilation (NV) is considered one of the passive building strategies used for reducing cooling energy demand. The utilization of nature wind for cooling down indoor thermal environment to reach thermal comfort requires knowledge of adequately positioning the building fenestrations, designing inlet-outlet related opening ratios, planning unobstructed cross ventilation paths, and, the most important, assessing the utilization feasibility base on local climatic variables. Furthermore, factors that influence the indoor thermal condition include building envelope heat gain, indoor air velocity, indoor heat gain (e.g. heat discharges from occupant's body, lighting fixture, electrical appliances), and outdoor climate. Among the above, the indoor thermal performance of NV building is significantly dependent to outdoor climate conditions. In hot and humid Taiwan, under college school classrooms are usually operated in natural ventilation mode and are more vulnerable to climate change in regard to maintain indoor thermal comfort. As climate changes in progress, NV classrooms would expect to encounter more events of overheating in the near future, which result in more severe heat stress, and would risk the utilization of natural ventilation. To evaluate the overheating risk under the influence of recent climate change, an actual top floor elementary school classroom with 30 students located at north Taiwan was modeled. Long-term local hourly meteorological data were gathered and further constructed into EnergyPlus Weather Files (EPWs) format for building thermal dynamic simulation to discuss the indoor thermal environmental variation during the period of 1998 to 2012 by retrospective simulation. As indoor thermal environment is an overall condition resulting from a series combination of various factors, sub-hourly building simulation tool, EnergyPlus, coupled with the above fifteen years' EPWs was adopted to predict hourly indoor parameters of mean radiant

  20. Optical Characteristics of Oil Palm Fresh Fruits Bunch (FFB Under Three Spectrum Regions Influence for Harvest Decision

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    Cherie Dinah

    2015-01-01

    Full Text Available In current practice, appearance was used to determine ripeness for oil palm fresh fruits bunch (FFB, that accompanied by detachment of fruit-lets from the bunch. The FFB from marihat clone harvested at five ripeness stages, under ripeness (F0, ripeness (F1, F2, F3, and over ripeness (F4. At every ripeness stages, differences of oil content and pigment accumulation were observed on the bunch. All samples recorded using a digital camera (10 Mpixel from 2, 7, 10, and 15 meter distance, simulating variation of light intensity upon recording. During image recording, three lighting were used, namely ultraviolet lamp (320-380 nm, visible light lamp (400-700 nm and infrared lamp (720-1100 nm, all have similar power output of 600watt. Camera point of view was set to cover a square area of 12,5cm by 12,5cm of the frontal area of FFB, each picture produced has 3888 by 2952 pixel. Image processing software created to extract digital RGB information from the images, and displayed the information in histogram. From the experiment, it was observed that the changes of intensity influence the RGB value of recorded image with reverse correlation, and longer wave light spectrum produce smaller RGB value.  The correlation model among image recording distance and RGB of the image display similar nature.  From three color channels, G represents better correlation for sample’s oil content determination.  Using UV and visible lighting, the FFB samples may be determined for harvest decision, up to seven meter observation distance.

  1. Social support and age influence distress outcomes differentially across urban, regional and remote Australia: an exploratory study

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    Allen Joanne

    2012-10-01

    Full Text Available Abstract Background The variation of determinants of mental health with remoteness has rarely been directly examined. The current research aims to examine whether the association of psychosocial factors with psychological distress outcomes varies with increasing remoteness. Methods Participants were persons aged 55 and over from two community cohorts sampling from across rural and urban New South Wales (N = 4219; mean age = 69.00 years; 46.1% male. Measures of social support from these studies were calibrated to facilitate comparison across the sample. Remoteness was assessed using a continuous measure, the Accessibility/Remoteness Index of Australia. The association between demographic characteristics, social support, remoteness, and their interactions with remoteness in the prediction of high psychological distress (cut-off > 21 on the Kessler 10 were examined using logistic regression. Results Not being in a married or defacto relationship (OR 0.69; 99% CI 0.51-0.94, lower education (OR 0.52; 99% CI 0.38-0.71 and decreased social support (OR 0.36; 99% CI 0.31-0.42 significantly predicted psychological distress. There was a significant interaction of age and remoteness (OR 0.84; 99% CI 0.67-1.00, indicating that as remoteness increases, older persons are less likely to be highly distressed, as well as a significant interaction of social support and remoteness (OR 1.22; 99% CI 1.04-1.44, indicating that as remoteness decreases, persons with low levels of social support are more likely to be highly distressed. Conclusions Remoteness may moderate the influence of social support and age on psychological distress outcomes.

  2. The influence of hyperoxia on regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV) and cerebral blood flow velocity in the middle cerebral artery (CBFVMCA) in human volunteers.

    Science.gov (United States)

    Kolbitsch, Christian; Lorenz, Ingo H; Hörmann, Christoph; Hinteregger, Martin; Löckinger, Alexander; Moser, Patrizia L; Kremser, Christian; Schocke, Michael; Felber, Stephan; Pfeiffer, Karl P; Benzer, Arnulf

    2002-09-01

    Conflicting results reported on the effects of hyperoxia on cerebral hemodynamics have been attributed mainly to methodical and species differences. In the present study contrast-enhanced magnetic resonance imaging (MRI) perfusion measurement was used to analyze the influence of hyperoxia (fraction of inspired oxygen (FiO2) = 1.0) on regional cerebral blood flow (rCBF) and regional cerebral blood volume (rCBV) in awake, normoventilating volunteers (n = 19). Furthermore, the experiment was repeated in 20 volunteers for transcranial Doppler sonography (TCD) measurement of cerebral blood flow velocity in the middle cerebral artery (CBFV(MCA)). When compared to normoxia (FiO2 = 0.21), hyperoxia heterogeneously influenced rCBV (4.95 +/- 0.02 to 12.87 +/- 0.08 mL/100g (FiO2 = 0.21) vs. 4.50 +/- 0.02 to 13.09 +/- 0.09 mL/100g (FiO2 = 1.0). In contrast, hyperoxia diminished rCBF in all regions (68.08 +/- 0.38 to 199.58 +/- 1.58 mL/100g/min (FiO2 = 0.21) vs. 58.63 +/- 0.32 to 175.16 +/- 1.51 mL/100g/min (FiO2 = 1.0)) except in parietal and left frontal gray matter. CBFV(MCA) remained unchanged regardless of the inspired oxygen fraction (62 +/- 9 cm/s (FiO2 = 0.21) vs. 64 +/- 8 cm/s (FiO2 = 1.0)). Finding CBFV(MCA) unchanged during hyperoxia is consistent with the present study's unchanged rCBF in parietal and left frontal gray matter. In these fronto-parietal regions predominantly fed by the middle cerebral artery, the vasoconstrictor effect of oxygen was probably counteracted by increased perfusion of foci of neuronal activity controlling general behavior and arousal. PMID:12413599

  3. IDENTIFICATION OF THOSE VARIABLES THAT HAVE A SIGNIFICANT INFLUENCE ON THE EXPECTED NUMBER OF DAYS OF STAYING IN THE CENTRE DEVELOPMENT REGION OF ROMANIA

    Directory of Open Access Journals (Sweden)

    Erika KULCSÁR

    2010-06-01

    Full Text Available I started from the assumption that there are more variables that have a significant influence on the expected number of days of staying in the Centre Development Region. To identify those variables this paper includes the analysis of variance with two variables that are not interacting, in this case the dependent variable is the question "How many days did you plan to stay in Centre Development Region?" and the independent variables are: "What is the purpose of your stay?" "What is the highest level of education?". Given that there are cases when interactions occur between variables, I also analyzed the interaction effects between the two independent variables. The paper also includes an ANOVA analysis with three variables between which interactions relationships occur. After identifying the dependency relations between the variables I found that the inclusion of the third variable, namely the "Marital status" of respondents, adds value to the model. Following the results obtained by ANOVA analysis, I identified those socio-demographic characteristics that, in my opinion, companies that operate on tourist market in the Center Development Region should consider when fundamenting marketing strategies in tourism.

  4. Factors influencing surgical delay after hip fracture in hospitals of Emilia Romagna Region, Italy: a multilevel analysis.

    Science.gov (United States)

    Belotti, Laura Maria Beatrice; Bartoli, Simona; Trombetti, Susanna; Montella, Maria Teresa; Toni, Aldo; De Palma, Rossana

    2013-01-01

    Hip fracture is becoming a major public health concern, with associated mortality and morbidity particularly in the elderly. This study aims to investigate factors (i.e. patient factors and hospital variables) associated with increased risk for delaying surgery after hip fractures, and to assess whether and to what extent timing was associated with mortality risk. All patients aged 65 and over, resident in Emilia Romagna Region (Italy) and admitted to hospital for hip fracture (2009 - 2010) were selected. Data on surgical delay were adjusted using multilevel logistic regression model. A Cox proportional hazard model was fitted to a propensity score matched sample to assess mortality between delayed and early treated patients. Of the 10, 995 patients included (mean age: 83.3 years), 44.9% underwent surgery within 2 days. Significant risk factors for delayed surgery were: gender (OR: 1.16), comorbidity (OR: 1.29), anticoagulant (OR: 7.64) ,antiplatelet medication (OR: 2.43) , type of procedure (OR: 1.37) and day of admission (OR: Thu-Fri: 6.05; Sat-Sun: 1.17). Type of hospital and annual volume of hip fracture surgeries were not sufficient to explain hospital variability. A significant difference in mortality rate between early and delayed surgery emerged six months post surgery. PMID:23397198

  5. Whole brain and brain regional coexpression network interactions associated with predisposition to alcohol consumption.

    Directory of Open Access Journals (Sweden)

    Lauren A Vanderlinden

    Full Text Available To identify brain transcriptional networks that may predispose an animal to consume alcohol, we used weighted gene coexpression network analysis (WGCNA. Candidate coexpression modules are those with an eigengene expression level that correlates significantly with the level of alcohol consumption across a panel of BXD recombinant inbred mouse strains, and that share a genomic region that regulates the module transcript expression levels (mQTL with a genomic region that regulates alcohol consumption (bQTL. To address a controversy regarding utility of gene expression profiles from whole brain, vs specific brain regions, as indicators of the relationship of gene expression to phenotype, we compared candidate coexpression modules from whole brain gene expression data (gathered with Affymetrix 430 v2 arrays in the Colorado laboratories and from gene expression data from 6 brain regions (nucleus accumbens (NA; prefrontal cortex (PFC; ventral tegmental area (VTA; striatum (ST; hippocampus (HP; cerebellum (CB available from GeneNetwork. The candidate modules were used to construct candidate eigengene networks across brain regions, resulting in three "meta-modules", composed of candidate modules from two or more brain regions (NA, PFC, ST, VTA and whole brain. To mitigate the potential influence of chromosomal location of transcripts and cis-eQTLs in linkage disequilibrium, we calculated a semi-partial correlation of the transcripts in the meta-modules with alcohol consumption conditional on the transcripts' cis-eQTLs. The function of transcripts that retained the correlation with the phenotype after correction for the strong genetic influence, implicates processes of protein metabolism in the ER and Golgi as influencing susceptibility to variation in alcohol consumption. Integration of these data with human GWAS provides further information on the function of polymorphisms associated with alcohol-related traits.

  6. Influences of the 2010 Eyjafjallajökull volcanic plume on air quality in the northern Alpine region

    Directory of Open Access Journals (Sweden)

    K. Schäfer

    2011-03-01

    sulphur dioxide under high solar irradiance. It became evident that during the course of several days, the Eyjafjallajökull volcanic emissions influenced the near-surface atmosphere and thus the ambient air quality. Following knowledge about health effects of air pollutants and volcanic plume compounds, it is assumed that the volcanic plume contributed to the overall exposure of the population and therefore may have had minor effects on the exacerbation of respiratory and cardiovascular symptoms.

  7. Quality of potatoes grown in various regions of Serbia as influenced by heavy metal and pesticide residues concentrations

    Directory of Open Access Journals (Sweden)

    Rajković Miloš B.

    2002-01-01

    Full Text Available It is possible to decompose starch into monosaccharides by the method of acid starch hydrolysis. By applying appropriate chemical procedure, a main solution is obtained, from which aliquots are taken after filtration to determine of the present glucose according to Luff-Shoorlu method. The analysed potatoes of cv. Desiree, grown on various sites in Serbia, have starch content that corresponds to available literature data. The highest starch content is found in potatoes from Ivanjica and Novi Pazar, i.e. from the areas where climate factors, air temperature, and land relief are favourable for potato growing. Lower starch contents are found in potatoes grown in flat areas with warmer climate and drier periods. Those are sites in PKB-Belgrade, Smederevo, Dobanovci and Mrčajevci areas, where the values obtained by experimental procedure are very similar. The lowest starch content is found in potatoes from Belegiš and Guča sites, where starch content is lower than normal from literature values, which may be explained by some special causes (climate, location, irrigation. On the basis of heavy metal contents in potato samples, it may be concluded that potatoes originating from sites famous for potato production are contaminated with Cd the content of which exceeds concentrations permitted by regulations. The presence of Cd in potato samples may also be explained by the application of phosphate fertilizers in higher (or recommended rates. However, the soil itself should also be investigated, especially concerning the content of Cd and pH value. Thus, the influence of the soil itself should be established compared to fertilizer application in the current season. Presence of Cd in potatoes, on the other hand, is highly unfavourable because it prevents its utilization in nutrition, but also as a raw material for further processing of products based on potatoes: chips, etc. Also, Cd presence in foods is strictly controlled by EU, which prevents possible

  8. Influence of the long term use of a computer on median, ulnar and radial sensory nerves in the wrist region

    Directory of Open Access Journals (Sweden)

    Belgin Bamac

    2014-12-01

    Full Text Available Objectives: Repetitive microtrauma or overuse injuries may often affect upper extremities of the long term computer users. The aim of this study was to compare sensory nerve conduction velocities (SNCV for median, radial and ulnar nerves in the wrist of computer users with the same parameters in controls who do not use computers regularly. Material and Methods: Twenty one male computer users (age: mean (M = 28.3 years ± standard deviation (SD = 7.5 years and 21 male control subjects (age: M±SD = 24.1±4.6 years were recruited for the study. Limb length and the perimeters of the dominant arm and forearm were measured for each subject. The neurophysiological study consisted of measuring sensory nerve conduction of the median, ulnar and radial nerves. Results: The sensory conduction velocities of both median and ulnar nerves were significantly delayed in the dominant arm of the computer users compared to the controls. In addition, sensory conduction velocity of the median nerve was significantly delayed in the dominant extremity of the computer users compared to their non-dominant extremity. Conclusions: This study shows that computer users have a tendency toward developing median and ulnar sensory nerve damage in the wrist region. Mechanism of delayed SNCV in the median and ulnar nerves may be due to sustained extension and ulnar deviation of the wrist during computer mouse use and typing. Reduced SNCV changes were more apparent on the dominant side of the median nerve. This may indicate the increased neural deficits related to an increased use of the dominant side. Further investigation is needed to determine how to reduce potential risk factors at this stage in order to prevent development of median or ulnar neuropathy in the long term computer users.

  9. Influence of the hinge region and its adjacent domains on binding and signaling patterns of the thyrotropin and follitropin receptor.

    Science.gov (United States)

    Schaarschmidt, Jörg; Huth, Sandra; Meier, René; Paschke, Ralf; Jaeschke, Holger

    2014-01-01

    Glycoprotein hormone receptors (GPHR) have a large extracellular domain (ECD) divided into the leucine rich repeat (LRR) domain for binding of the glycoprotein hormones and the hinge region (HinR), which connects the LRR domain with the transmembrane domain (TMD). Understanding of the activation mechanism of GPHRs is hindered by the unknown interaction of the ECD with the TMD and the structural changes upon ligand binding responsible for receptor activation. Recently, our group showed that the HinR of the thyrotropin receptor (TSHR) can be replaced by those of the follitropin (FSHR) and lutropin receptor (LHCGR) without effects on surface expression and hTSH signaling. However, differences in binding characteristics for bovine TSH at the various HinRs were obvious. To gain further insights into the interplay between LRR domain, HinR and TMD we generated chimeras between the TSHR and FSHR. Our results obtained by the determination of cell surface expression, ligand binding and G protein activation confirm the similar characteristics of GPHR HinRs but they also demonstrate an involvement of the HinR in ligand selectivity indicated by the observed promiscuity of some chimeras. While the TSHR HinR contributes to specific binding of TSH and its variants, no such contribution is observed for FSH and its analog TR4401 at the HinR of the FSHR. Furthermore, the charge distribution at the poorly characterized LRR domain/HinR transition affected ligand binding and signaling even though this area is not in direct contact with the ligand. In addition our results also demonstrate the importance of the TMD/HinR interface. Especially the combination of the TSHR HinR with the FSHR-TMD resulted in a loss of cell surface expression of the respective chimeras. In conclusion, the HinRs of GPHRs do not only share similar characteristics but also behave as ligand specific structural and functional entities. PMID:25340405

  10. Influence of the hinge region and its adjacent domains on binding and signaling patterns of the thyrotropin and follitropin receptor.

    Directory of Open Access Journals (Sweden)

    Jörg Schaarschmidt

    Full Text Available Glycoprotein hormone receptors (GPHR have a large extracellular domain (ECD divided into the leucine rich repeat (LRR domain for binding of the glycoprotein hormones and the hinge region (HinR, which connects the LRR domain with the transmembrane domain (TMD. Understanding of the activation mechanism of GPHRs is hindered by the unknown interaction of the ECD with the TMD and the structural changes upon ligand binding responsible for receptor activation. Recently, our group showed that the HinR of the thyrotropin receptor (TSHR can be replaced by those of the follitropin (FSHR and lutropin receptor (LHCGR without effects on surface expression and hTSH signaling. However, differences in binding characteristics for bovine TSH at the various HinRs were obvious. To gain further insights into the interplay between LRR domain, HinR and TMD we generated chimeras between the TSHR and FSHR. Our results obtained by the determination of cell surface expression, ligand binding and G protein activation confirm the similar characteristics of GPHR HinRs but they also demonstrate an involvement of the HinR in ligand selectivity indicated by the observed promiscuity of some chimeras. While the TSHR HinR contributes to specific binding of TSH and its variants, no such contribution is observed for FSH and its analog TR4401 at the HinR of the FSHR. Furthermore, the charge distribution at the poorly characterized LRR domain/HinR transition affected ligand binding and signaling even though this area is not in direct contact with the ligand. In addition our results also demonstrate the importance of the TMD/HinR interface. Especially the combination of the TSHR HinR with the FSHR-TMD resulted in a loss of cell surface expression of the respective chimeras. In conclusion, the HinRs of GPHRs do not only share similar characteristics but also behave as ligand specific structural and functional entities.

  11. NEW YOUNG STAR CANDIDATES IN BRC 27 AND BRC 34

    Energy Technology Data Exchange (ETDEWEB)

    Rebull, L. M.; Laher, R.; Legassie, M. [Spitzer Science Center/Caltech, M/S 220-6, 1200 E. California Blvd., Pasadena, CA 91125 (United States); Johnson, C. H.; Carlson, S.; Clark, M.; Killingstad, N.; Koop, S. [Breck School, 123 Ottawa Avenue N., Golden Valley, MN 55422 (United States); Gibbs, J. C.; Aryal, S.; Canakapalli, T. S. [Glencoe High School, 2700 NW Glencoe Rd., Hillsboro, OR 97124 (United States); Linahan, M.; Ezyk, N.; Fagan, J. [Carmel Catholic High School, One Carmel Parkway, Mundelein, IL 60060 (United States); Sartore, D.; Badura, K. S. [Pine Ridge High School, 926 Howland Blvd., Deltona, FL 32738 (United States); Armstrong, J. D. [Las Cumbres Observatory Global Telescope (LCOGT) Network, Inc., 6740 Cortona Dr. Suite 102, Goleta, CA 93117 (United States); Allen, L. E. [National Optical Astronomy Observatory (NOAO), Tucson, AZ 85719 (United States); McGehee, P. [Infrared Processing and Analysis Center (IPAC), M/S 220-6, 1200 E. California Blvd., Pasadena, CA 91125 (United States); Padgett, D. L., E-mail: rebull@ipac.caltech.edu [NASA' s Goddard Space Flight Center (GSFC), 8800 Greenbelt Rd., Greenbelt, MD 20771 (United States); and others

    2013-01-01

    We used archival Spitzer Space Telescope mid-infrared data to search for young stellar objects (YSOs) in the immediate vicinity of two bright-rimmed clouds, BRC 27 (part of CMa R1) and BRC 34 (part of the IC 1396 complex). These regions both appear to be actively forming young stars, perhaps triggered by the proximate OB stars. In BRC 27, we find clear infrared excesses around 22 of the 26 YSOs or YSO candidates identified in the literature, and identify 16 new YSO candidates that appear to have IR excesses. In BRC 34, the one literature-identified YSO has an IR excess, and we suggest 13 new YSO candidates in this region, including a new Class I object. Considering the entire ensemble, both BRCs are likely of comparable ages, within the uncertainties of small number statistics and without spectroscopy to confirm or refute the YSO candidates. Similarly, no clear conclusions can yet be drawn about any possible age gradients that may be present across the BRCs.

  12. Identification of new transitional disk candidates in Lupus with Herschel

    CERN Document Server

    Bustamante, I; Ribas, Á; Bouy, H; Prusti, T; Pilbratt, G L; André, Ph

    2015-01-01

    New data from the Herschel Space Observatory are broadening our understanding of the physics and evolution of the outer regions of protoplanetary disks in star forming regions. In particular they prove to be useful to identify transitional disk candidates. The goals of this work are to complement the detections of disks and the identification of transitional disk candidates in the Lupus clouds with data from the Herschel Gould Belt Survey. We extracted photometry at 70, 100, 160, 250, 350 and 500 $\\mu$m of all spectroscopically confirmed Class II members previously identified in the Lupus regions and analyzed their updated spectral energy distributions. We have detected 34 young disks in Lupus in at least one Herschel band, from an initial sample of 123 known members in the observed fields. Using the criteria defined in Ribas et al. (2013) we have identified five transitional disk candidates in the region. Three of them are new to the literature. Their PACS-70 $\\mu$m fluxes are systematically higher than thos...

  13. IκBα polymorphism at promoter region (rs2233408 influences the susceptibility of gastric cancer in Chinese

    Directory of Open Access Journals (Sweden)

    Sung Joseph JY

    2010-02-01

    Full Text Available Abstract Background Nuclear factor of kappa B inhibitor alpha (IκBα protein is implicated in regulating a variety of cellular process from inflammation to tumorigenesis. The objective of this study was to investigate the susceptibility of rs2233408 T/C genotype in the promoter region of IκBα to gastric cancer and the association of this polymorphism with clinicopathologic variables in gastric cancer patients. Methods A population-based case-control study was conducted between 1999 and 2006 in Guangdong Province, China. A total of 564 gastric cancer patients and 566 healthy controls were enrolled in this study. rs2233408 genotypes in IκBα were analyzed by TaqMan SNP genotyping assay. Results Both rs2233408 T homozygote (TT and T heterozygotes (TC and TT had significantly reduced gastric cancer risk (TT: OR = 0.250, 95% CI = 0.069-0.909, P = 0.035; TC and TT: OR = 0.721, 95% CI = 0.530-0.981, P = 0.037, compared with rs2233408 C homozygote (CC. rs2233408 T heterozygotes were significantly associated with reduced risk of intestinal-type gastric cancer with ORs of 0.648 (95% CI = 0.459-0.916, P = 0.014, but not with the diffuse or mix type of gastric cancer. The association between rs2233408 T heterozygotes and gastric cancer appeared more apparent in the older patients (age>40 (OR = 0.674, 95% CI = 0.484-0.939, P = 0.02. rs2233408 T heterozygotes was associated with non-cardiac gastric cancer (OR = 0.594, 95% CI = 0.411-0.859, P = 0.006, but not with cardiac gastric cancer. However, rs2233408 polymorphism was not associated with the prognosis of gastric cancer patients. Conclusions IκBα rs2233408 T heterozygotes were associated with reduced risk of gastric cancer, especially for the development of certain subtypes of gastric cancer in Chinese population.

  14. Synoptic influences on springtime tropospheric O3 and CO over the North American export region observed by TES

    Directory of Open Access Journals (Sweden)

    R. Talbot

    2009-06-01

    Full Text Available The relationship between synoptic circulation patterns over the western North Atlantic Ocean in spring (March, April, and May and tropospheric O3 and CO was investigated using retrievals from the Tropospheric Emission Spectrometer (TES for 2005 and 2006. Seasonal composites of TES retrievals reprocessed to remove the artificial geographic structure added from the a priori revealed a channel of slightly elevated O3 (>55 ppbv and CO (>115 ppbv at the 681 hPa retrieval level between 30° N and 45° N extending from North America out over the Atlantic Ocean. Ozone and CO in this region were correlated at r=0.22 with a slope value of 0.13 mol mol−1 indicative of the overall impact of photochemical chemical processes in North American continental export. Composites of TES retrievals for the six predominant circulation patterns identified as map types from sea level pressure fields of the NCEP FNL analyses showed large variability in the distribution of tropospheric O3. Map types MAM2 and MAM3 featuring cyclones near the US east coast produced the greatest export to the lower free troposphere with O3>65 ppbv and a relatively well-defined O3-CO correlation (slope values near 0.20 mol mol−1. The ensembles of HYSPLIT backward trajectories indicated that the high O3 levels were possibly a result of pollutants lofted to the free troposphere by the warm conveyor belt (WCB of a cyclone. An important finding was that pollutant export occurred in the main WCB branch to the east of the cyclone and in a secondary branch circling to the back of the cyclone center. Conversely, a map type featuring a large anticyclone dominating the flow over the US east coast (MAM6 restricted export with O3 levels generally <55 ppbv and CO levels generally <110 ppbv. There was also evidence of stratospheric intrusions particularly to the north of 45° N in the 316 hPa composites predominately for MAM1 which featured a large cyclone near Newfoundland. However, the concurrence of

  15. Possible influence of atmospheric circulations on winter haze pollution in the Beijing-Tianjin-Hebei region, northern China

    Science.gov (United States)

    Zhang, Z.; Zhang, X.; Gong, D.; Kim, S.-J.; Mao, R.; Zhao, X.

    2016-01-01

    Using the daily records derived from the synoptic weather stations and the NCEP/NCAR and ERA-Interim reanalysis data, the variability of the winter haze pollution (indicated by the mean visibility and number of hazy days) in the Beijing-Tianjin-Hebei (BTH) region during the period 1981 to 2015 and its relationship with the atmospheric circulations at middle-high latitude were analyzed in this study. The winter haze pollution in BTH had distinct inter-annual and inter-decadal variabilities without a significant long-term trend. According to the spatial distribution of correlation coefficients, six atmospheric circulation indices (I1 to I6) were defined from the key areas in sea level pressure (SLP), zonal and meridional winds at 850 hPa (U850, V850), geopotential height field at 500 hPa (H500), zonal wind at 200 hPa (U200), and air temperature at 200 hPa (T200), respectively. All of the six indices have significant and stable correlations with the winter visibility and number of hazy days in BTH. In the raw (unfiltered) correlations, the correlation coefficients between the six indices and the winter visibility (number of hazy days) varied from 0.57 (0.47) to 0.76 (0.6) with an average of 0.65 (0.54); in the high-frequency ( level, and is then accompanied by a reduction (increase) of horizontal advection and vertical convection (relative humidity) in the lowest troposphere and a reduced boundary layer height in BTH and its neighboring areas, which are favorable for the formation of haze pollution in BTH winter, and vice versa. The high level of the prediction statistics and the reasonable mechanism suggested that the winter haze pollution in BTH can be forecasted or estimated credibly based on the optimized atmospheric circulation indices. Thus it is helpful for government decision-making departments to take action in advance in dealing with probably severe haze pollution in BTH indicated by the atmospheric circulation conditions.

  16. Evolution Characteristics and Influence Factors of Deep Groundwater Depression Cone in North China Plain, China--A Case Study in Cangzhou Region

    Institute of Scientific and Technical Information of China (English)

    Yasong Li; Fawang Zhang; Zhantao Han; Ping Wang; Honghan Chen; Zhaoji Zhang

    2014-01-01

    The North China Plain (NCP) is one of the global hotspots of groundwater depletion, groundwater is almost the only source of water for agricultural, industrial and drinking water in this region. After long-term’s over-exploitation of deep groundwater, there appeared several deep ground-water depression cones, such as Cangzhou cone, Dezhou cone, Hengshui cone, Tianjin cone, etc., in which the Cangzhou cone is one of the typical cones for its special geography and hydrogeology condi-tions. In this study, the authors intended to analyze the evolution characteristics and influence factors of deep groundwater depression cone in Cangzhou region, especially the No. III aquifer depression cone, which is the main exploitation zone in this region. Analysis of the evolution of the groundwater depres-sion cone of the No. III aquifer group in Cangzhou region showed that this process can be divided into four stages, namely, development, stable development, rapid expansion, and gradual recovery. The shape and evolution characteristics of the depression cone at different stages are described by analyzing the evolution of the -30, -40, and -50 contours of the groundwater table, for example the closed area of water table contour of -50 m has been enlarged from 95 km2 in 1985 to 6 528.5 km2in 2005. The dominant factors that affect the evolution characteristics at different stages are proposed. The results showed that relatively long dry periods with less precipitation, special geological and hydrogeological conditions, and sharply increased water consumption for industrial and agricultural development are the main factors that cause the formation of deep groundwater depression cones. Meanwhile, an environmental response against groundwater exploitation is presented, and rational solutions are suggested to avert water crisis.

  17. A candidate syntenic genetic locus is associated with voluntary exercise levels in mice and humans

    NARCIS (Netherlands)

    Kostrzewa, E.; Brandys, M. K.; van Lith, H. A.; Kas, M. J H

    2015-01-01

    Individual levels of physical activity, and especially of voluntary physical exercise, highly contribute to the susceptibility for developing metabolic, cardiovascular diseases, and potentially to psychiatric disorders. Here, we applied a cross-species approach to explore a candidate genetic region

  18. [The assessment of biocenosis contamination in the region of radioactive waste storage (RWS) placing and influence of this storage on rodents].

    Science.gov (United States)

    Vasil'ev, A N; Synzynys, B I; Ul'ianova, L P; Kovalev, O A; Smoryzanova, O A; Starkov, O V; Latynova, N E; Kruglov, S V; Momot, O A; Koz'min, G V

    2007-01-01

    The results of radiative and of chemical monitoring show definite contamination of this zone by 90Sr and toxic metals. The essential local contaminations of geosystems (up to 2.3 x 10(4) Bk/kg of soil) require in environmental condition assessment at biocenosis level. Biotesting found the increase of metallothioneines levels in kidney (up to 15.63 microg/g of tissue) and liver (up to 19.22 microg/g of tissue) of rodents inhabited in the region of RWS placing as compared with the control group (3.51 and 4.44 microg/g of tissue accordingly). Besides, the decrease of total quantity of leucocytes (by 14.5% as compared with the control group) and absolute quantity all forms of them in animal blood were noted. It was assumed the increase of protein--MT is the result of complex influence by ionizing radiation and toxic metals. PMID:18051689

  19. The influence of electron energy quantization in a space-charge region on the accumulation capacitance of InAs metal-oxide-semiconductor capacitors

    International Nuclear Information System (INIS)

    The influence of electron energy quantization in a space-charge region on the accumulation capacitance of the InAs-based metal-oxide-semiconductor capacitors (MOSCAPs) has been investigated by modeling and comparison with the experimental data from Au/anodic layer(4-20 nm)/n-InAs(111)A MOSCAPs. The accumulation capacitance for MOSCAPs has been calculated by the solution of Poisson equation with different assumptions and the self-consistent solution of Schrödinger and Poisson equations with quantization taken into account. It was shown that the quantization during the MOSCAPs accumulation capacitance calculations should be taken into consideration for the correct interface states density determination by Terman method and the evaluation of gate dielectric thickness from capacitance-voltage measurements

  20. Influence of southern oscillation and SSTs over Nino-3.4 region on the winter monsoon rainfall over coastal Andhra Pradesh

    Indian Academy of Sciences (India)

    O S R U Bhanu Kumar; C V Naidu; S R L Rao

    2004-09-01

    An analysis of the mean monthly data of 124 years reveals that the relationship between the Southern Oscillation Index in September and the winter monsoon rainfall (WMR) over Coastal Andhra Pradesh (CAP) is variable and non-stationary. In the recent four decades, however, SOI (Sept) is negatively and significantly correlated with CAP WMR. A similar analysis is performed using 50 years of mean monthly SSTs over Nino-3.4 region in August and September and CAP WMR to detect a possible relationship and there is a striking positive relation between them. In both of the above cases, the September signal is more significant in the recent four decades than for the other months and seasons for probable prediction of CAP WMR. Finally, to examine the influence of SO on the winter monsoon rainfall, a non-parametric test "Mann-Whitney Rank Statistics" test has been applied to the rainfall associated with extreme positive and negative SOI events.

  1. Modeling the influence of alternative forest management scenarios on wood production and carbon storage: A case study in the Mediterranean region.

    Science.gov (United States)

    Bottalico, Francesca; Pesola, Lucia; Vizzarri, Matteo; Antonello, Leonardo; Barbati, Anna; Chirici, Gherardo; Corona, Piermaria; Cullotta, Sebastiano; Garfì, Vittorio; Giannico, Vincenzo; Lafortezza, Raffaele; Lombardi, Fabio; Marchetti, Marco; Nocentini, Susanna; Riccioli, Francesco; Travaglini, Davide; Sallustio, Lorenzo

    2016-01-01

    Forest ecosystems are fundamental for the terrestrial biosphere as they deliver multiple essential ecosystem services (ES). In environmental management, understanding ES distribution and interactions and assessing the economic value of forest ES represent future challenges. In this study, we developed a spatially explicit method based on a multi-scale approach (MiMoSe-Multiscale Mapping of ecoSystem services) to assess the current and future potential of a given forest area to provide ES. To do this we modified and improved the InVEST model in order to adapt input data and simulations to the context of Mediterranean forest ecosystems. Specifically, we integrated a GIS-based model, scenario model, and economic valuation to investigate two ES (wood production and carbon sequestration) and their trade-offs in a test area located in Molise region (Central Italy). Spatial information and trade-off analyses were used to assess the influence of alternative forest management scenarios on investigated services. Scenario A was designed to describe the current Business as Usual approach. Two alternative scenarios were designed to describe management approaches oriented towards nature protection (scenario B) or wood production (scenario C) and compared to scenario A. Management scenarios were simulated at the scale of forest management units over a 20-year time period. Our results show that forest management influenced ES provision and associated benefits at the regional scale. In the test area, the Total Ecosystem Services Value of the investigated ES increases 85% in scenario B and decreases 82% in scenario C, when compared to scenario A. Our study contributes to the ongoing debate about trade-offs and synergies between carbon sequestration and wood production benefits associated with socio-ecological systems. The MiMoSe approach can be replicated in other contexts with similar characteristics, thus providing a useful basis for the projection of benefits from forest

  2. Genotype-environment interaction of maternal influence characteristics in Nellore cattle bred in the Brazilian humid tropical regions by reaction norm

    Directory of Open Access Journals (Sweden)

    Jorge Luís Ferreira

    2015-08-01

    Full Text Available Reaction Norm (RN is the study of genotype-environment interaction (GxE that complies with alternative ways of genotypes within different environments. This study was carried out to verify GxE by a reaction norm model of weights at 120 (W120 and 210 (W210 days of age in Nellore cattle raised in the Humid Tropical Regions of Brazil. Environmental gradients were obtained by solutions of contemporary groups which were fitted as co-variables in the random regression model via reaction norms. Mean weight at 120 days of age was 127.97 kg, and environmental gradients ranged between -27 and +26 kg. Average was 185.60 kg at 210 days of age and gradients ranged from -54 to +55 kg. Scale changes in the breeding values and heritability estimates occurred along the gradients for the two weights; the genetic correlations between breeding value breeding values were also similar for both weights. These correlations were high between the close gradients, and low to even negative between extreme environments. Slopes representing the environmental sensitivity were high, with changes of scale and changes in classification of ten bulls with a great numbers of calves for the two traits. When regression slopes of the ten bulls with the highest breeding value breeding values were evaluated, these values were different in W120 from those in W210, perhaps due to the greater influence of maternal effect on W120. These results characterize the influence of GxE on the pre-weaning weights of animals in the humid tropical regions of Brazil. Due to this, it is possible to get greater precision on the predictions of the animals breeding values breeding value. A less biased selection and a greater genetic progress occurred.

  3. Factors influencing elective science students’ perception of their Biology classroom environment in low and high academic achieving schools in the Central Region of Ghana

    Directory of Open Access Journals (Sweden)

    Otami, Deodat Charles

    2012-01-01

    Full Text Available The study investigated factors influencing elective science students’ perception of their Biology classroom environment in low and high academic achieving senior secondary schools in the Central Region of Ghana. The cross-sectional survey research design was adopted. Participants were 356 third-year elective science students, selection through a multi-stage sampling technique. Data were obtained using the Biology Classroom Environment Questionnaire (BCEQ. This was after the senior secondary schools that offer elective science program had been categorized into low and high academic achieving schools based on their performance in Senior Secondary School Certificate Examination/West Africa Senior Secondary School Examinations for five years. Two third-year intact classes were randomly selected from four schools under each category. Data analysis includes Factor and Item Analyses, and Multivariate Analysis of Variance. The findings revealed that four factors influence elective science students’ perception of their Biology classroom environment. The findings further suggested that elective science students in both school categories had a low perception of their Biology classroom environment but significantly different in favor of the elective science students in low academic achieving schools in teacher support, cooperation, and equity. Implications of the study are discussed and recommendations given.

  4. Parameters influencing SPET regional brain uptake of technetium-99m hexamethylpropylene amine oxime measured by calibrated point sources as an external standard

    International Nuclear Information System (INIS)

    Using calibrated point sources as an external standard to convert SPET brain counts into absolute values of regional brain uptake (rBU) of technetium-99m hexamethylpropylene amine oxime (HMPAO), the relative contribution of different parameters to interindividual variability of cerebellar rBU was examined in 33 healthy volunteers. Stepwise regression analysis identified body surface as the most important factor underlying interindividual variability, when compared with brain volume. In the normal volunteer population presented, age decrement of rBU corrected for body surface and brain volume equalled 60.5-0.20xage. Based on the data of eight normal volunteers, including four test-retest studies with heart rate (HR) differences greater than 5 units and four test-stress studies with doubling of heart rate after bicycle exercise, influence of heart rate may be expressed by the equation ΔrBU = 0.35 ΔHR. Clinically, estimation of the relative influence of different factors allows normalization and extension of the applicability of the rBU quantification method used from longitudinal studies to group comparisons. Interestingly, results of the Daily Stress Inventory Scale and a subjective rating scale suggest the absence of a significant influence of minor stress on rBU. When using one vial per patient, chromatography may be omitted in clinical routine practice and lipophilicity may be estimated as 90% of the injected dose, if administered within 10 min after preparation. Finally, sensitivity of the quantification method was tested in eight volunteers using acetazolamide brain activation and showed a mean increase in cerebellar rBU of 30.2%, varying between 14.1% and 75.9%. (orig./MG)

  5. An Efficient Approach for Candidate Set Generation

    OpenAIRE

    Nawar Malhis; Arden Ruttan; Hazem H. Refai

    2005-01-01

    When Apriori was first introduced as an algorithm for discovering association rules in a database of market basket data, the problem of generating the candidate set of the large set was a bottleneck in Apriori's performance, both in space and computational requirements. At first, many unsuccessful attempts were made to improve the generation of a candidate set. Later, other algorithms that out performed Apriori were developed that generate association rules without using a candidate set. They...

  6. Cardiac evaluation of liver transplant candidates

    OpenAIRE

    Mandell, Mercedes Susan; Lindenfeld, JoAnn; Tsou, Mei-Yung; Zimmerman, Michael

    2008-01-01

    Physicians previously thought that heart disease was rare in patients with end stage liver disease. However, recent evidence shows that the prevalence of ischemic heart disease and cardiomyopathy is increased in transplant candidates compared to most other surgical candidates. Investigators estimate that up to 26% of all liver transplant candidates have at least one critical coronary artery stenosis and that at least half of these patients will die perioperatively of cardiac complications. Ca...

  7. Identification of new transitional disk candidates in Lupus with Herschel

    Science.gov (United States)

    Bustamante, I.; Merín, B.; Ribas, Á.; Bouy, H.; Prusti, T.; Pilbratt, G. L.; André, Ph.

    2015-06-01

    Context. New data from the Herschel Space Observatory are broadening our understanding of the physics and evolution of the outer regions of protoplanetary disks in star-forming regions. In particular they prove to be useful for identifying transitional disk candidates. Aims: The goals of this work are to complement the detections of disks and the identification of transitional disk candidates in the Lupus clouds with data from the Herschel Gould Belt Survey. Methods: We extracted photometry at 70, 100, 160, 250, 350, and 500 μm of all spectroscopically confirmed Class II members previously identified in the Lupus regions and analyzed their updated spectral energy distributions. Results: We have detected 34 young disks in Lupus in at least one Herschel band, from an initial sample of 123 known members in the observed fields. Using recently defined criteria, we have identified five transitional disk candidates in the region. Three of them are new to the literature. Their PACS-70 μm fluxes are systematically higher than those of normal T Tauri stars in the same associations, as already found in T Cha and in the transitional disks in the Chamaeleon molecular cloud. Conclusions: Herschel efficiently complements mid-infrared surveys for identifying transitional disk candidates and confirms that these objects seem to have substantially different outer disks than the T Tauri stars in the same molecular clouds. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.Tables 5-7 and Figs. 3 and 4 are available in electronic form at http://www.aanda.org

  8. Identifying False Alarms in the Kepler Planet Candidate Catalog

    OpenAIRE

    Mullally, F.; Coughlin, Jeffery L.; Thompson, Susan E.; Christiansen, Jessie; Burke, Christopher; Clarke, Bruce D.; Haas, Michael R.

    2016-01-01

    We present a new automated method to identify instrumental features masquerading as small, long period planets in the \\kepler\\ planet candidate catalog. These systematics, mistakenly identified as planet transits, can have a strong impact on occurrence rate calculations because they cluster in a region of parameter space where Kepler's sensitivity to planets is poor. We compare individual transit-like events to a variety of models of real transits and systematic events, and use a Bayesian Inf...

  9. 区域文化对餐饮市场营销环境的影响%Influence of Regional Culture on Marketing Environment for Catering Businesses

    Institute of Scientific and Technical Information of China (English)

    刘雪峰

    2012-01-01

    中国区域文化类型众多,它通过餐饮市场需求、生产要素投入、饮食文化风格、产品创新以及人际沟通等众多方面来影响餐饮企业的营销行为,只有通过有效的战略整合,使多元文化得到充分发挥和利用,才能保证餐饮企业营销活动的成功。%China is a country of diversified regional cultures, and regional culture exerts a great influence on consumers' demand, input of production elements, culinary styles, innovation and interpersonal communication, which in turn might have an impact on catering businesses' marketing activities. It is only through effective strategic integration that multi-layer culture can be fully developed and exploited to ensure the success of marketing.

  10. THE INFLUENCE OF GEOLOGY ON BATTLEFIELD TERRAIN AND IT’S AFFECTS ON MILITARY OPERATIONS IN MOUNTAINS AND KARST REGIONS: EXAMPLES FROM WW1 AND AFGHANISTAN

    Directory of Open Access Journals (Sweden)

    Marko Zečević

    2007-12-01

    Full Text Available During the World War I conflict between the Austrian and Italian army, Austrian engineer units constructed hallways in the karst region of Soča river. Those hallways, karst phenomena (caverns, caves and other fortifications, gave the Austrian army a tactical advantage. The construction principle of caverns is the consequence of the geological structure of the terrain. We are watching another military conflict in Afghanistan. In country where many armies in history have been defeated, where the terrain morphology condition a guerilla tactic, where the function effect of modern military technology is limited by battlefield configuration and with low military value of individual target, we are creating a "picture" of the possible view of the future battlefield. Al-Qai'da operatives in east Afghanistan take advantage of the opportunity of geological structure of the terrain and construct tunnel network across natural caves. Although the tunnel network in Afghanistan is constructed mostly in sandstones and metamorphic rocks, we may partly compare it with Austrian hallways. In that sense this work shows the influence of geological structure of the terrain on the effect of military operations in mountains and karst regions, and the analogy between military operations on the Soča river and military operations in Afghanistan.

  11. Is the Sense of Agency in Schizophrenia Influenced by Resting-State Variation in Self-Referential Regions of the Brain?

    Science.gov (United States)

    Robinson, Jeffrey D; Wagner, Nils-Frederic; Northoff, Georg

    2016-03-01

    Schizophrenia is a disturbance of the self, of which the attribution of agency is a major component. In this article, we review current theories of the Sense of Agency, their relevance to schizophrenia, and propose a novel framework for future research. We explore some of the models of agency, in which both bottom-up and top-down processes are implicated in the genesis of agency. We further this line of inquiry by suggesting that ongoing neurological activity (the brain's resting state) in self-referential regions of the brain can provide a deeper level of influence beyond what the current models capture. Based on neuroimaging studies, we suggest that aberrant activity in regions such as the default mode network of individuals with schizophrenia can lead to a misattribution of internally/externally generated stimuli. This can result in symptoms such as thought insertion and delusions of control. Consequently, neuroimaging can contribute to a more comprehensive conceptualization and measurement of agency and potential treatment implications. PMID:26221048

  12. Soil pH, total phosphorus, climate and distance are the major factors influencing microbial activity at a regional spatial scale.

    Science.gov (United States)

    Cao, Haichuan; Chen, Ruirui; Wang, Libing; Jiang, Lanlan; Yang, Fen; Zheng, Shixue; Wang, Gejiao; Lin, Xiangui

    2016-01-01

    Considering the extensive functional redundancy in microbial communities and great difficulty in elucidating it based on taxonomic structure, studies on the biogeography of soil microbial activity at large spatial scale are as important as microbial community structure. Eighty-four soil samples were collected across a region from south to north China (about 1,000 km) to address the questions if microbial activity displays biogeographic patterns and what are driving forces. These samples represented different soil types, land use and climate. Redundancy analysis and nonmetric multidimensional scaling clearly revealed that soil microbial activities showed distinct differentiation at different sites over a regional spatial scale, which were strongly affected by soil pH, total P, rainfall, temperature, soil type and location. In addition, microbial community structure was greatly influenced by rainfall, location, temperature, soil pH and soil type and was correlated with microbial activity to some extent. Our results suggest that microbial activities display a clear geographic pattern that is greatly altered by geographic distance and reflected by climate, soil pH and total P over large spatial scales. There are common (distance, climate, pH and soil type) but differentiated aspects (TP, SOC and N) in the biogeography of soil microbial community structure and activity. PMID:27170469

  13. Discovery of optical candidate supernova remnants in Sagittarius

    Science.gov (United States)

    Alikakos, J.; Boumis, P.; Christopoulou, P. E.; Goudis, C. D.

    2012-08-01

    During an [O III] survey of planetary nebulae, we identified a region in Sagittarius containing several candidate supernova remants (SNRs) and obtained deep optical narrow-band images and spectra to explore their nature. We obtained images of the area of interest by acquiring observations in the emission lines of Hα + [N II], [S II] and [O III]. The resulting mosaic covers an area of 1.4° × 1.0°, where both filamentary and diffuse emission was discovered, suggesting that there is more than one SNR in the area. Deep long-slit spectra were also taken of eight different regions. Both the flux-calibrated images and the spectra show that the emission from the filamentary structures originates from shock-heated gas, while the photo-ionization mechanism is responsible for the diffuse emission. Part of the optical emission is found to be correlated with the radio at 4850 MHz suggesting that they are related, while the infrared emission found in the area at 12 μm and 22 μm marginally correlates with the optical. The presence of the [O III] emission line in one of the candidate SNRs implies that the shock velocities in the interstellar "clouds" are between 120 km s-1 and 200 km s-1, while its absence in the other candidate SNRs indicates that the shock velocities there are slower. For all candidate remnants, the [S II] λλ 6716/6731 ratio indicates that the electron densities are below 240 cm-3, while the Hα emission is measured to be between 0.6 and 41 × 10-17 erg s-1 cm-2 arcsec-2. The existence of eight pulsars within 1.5° of the center of the candidate SNRs also implies that there are many SNRs in the area as well as that the detected optical emission could be part of a number of supernovae explosions.

  14. An operational methodology for riparian land cover fine scale regional mapping for the study of landscape influence on river ecological status

    Science.gov (United States)

    Tormos, T.; Kosuth, P.; Souchon, Y.; Villeneuve, B.; Durrieu, S.; Chandesris, A.

    2010-12-01

    Preservation and restoration of river ecosystems require an improved understanding of the mechanisms through which they are influenced by landscape at multiple spatial scales and particularly at river corridor scale considering the role of riparian vegetation for regulating and protecting river ecological status and the relevance of this specific area for implementing efficient and realistic strategies. Assessing correctly this influence over large river networks involves accurate broad scale (i.e. at least regional) information on Land Cover within Riparian Areas (LCRA). As the structure of land cover along rivers is generally not accessible using moderate-scale satellite imagery, finer spatial resolution imagery and specific mapping techniques are needed. For this purpose we developed a generic multi-scale Object Based Image Analysis (OBIA) scheme able to produce LCRA maps in different geographic context by exploiting information available from very high spatial resolution imagery (satellite or airborne) and/or metric to decametric spatial thematic data on a given study zone thanks to fuzzy expert knowledge classification rules. A first experimentation was carried out on the Herault river watershed (southern of France), a 2650 square kilometers basin that presents a contrasted landscape (different ecoregions) and a total stream length of 1150 Km, using high and very high multispectral remotely-sensed images (10m Spot5 multispectral images and 0.5m aerial photography) and existing spatial thematic data. Application of the OBIA scheme produced a detailed (22 classes) LCRA map with an overall accuracy of 89% and a Kappa index of 83% according to a land cover pressures typology (six categories). A second experimentation (using the same data sources) was carried out on a larger test zone, a part of the Normandy river network (25 000 square kilometers basin; 6000 km long river network; 155 ecological stations). This second work aimed at elaborating a robust statistical

  15. Special Education Teacher Candidate Assessment: A Review

    Science.gov (United States)

    McCall, Zach; McHatton, Patricia Alvarez; Shealey, Monika Williams

    2014-01-01

    Teacher preparation has been under intense scrutiny in recent years. In order for preparation of special education teacher candidates to remain viable, candidate assessment practices must apply practices identified in the extant literature base, while special education teacher education researchers must extend this base with rigorous efforts to…

  16. Do People 'Like' Candidates on Facebook?

    DEFF Research Database (Denmark)

    Nielsen, Rasmus Kleis

    The online popularity of a few exceptional candidates has led many to suggest that social media have given politicians powerful ways of communicating directly with voters. In this paper, we examine whether this is happening on a significant scale and show, based on analysis of 224 candidates invo...

  17. A influência da proximidade tecnológica e geográfica sobre a inovação regional no Brasil The influence of the technological proximity and the geographical proximity on Brazilian regional innovation

    Directory of Open Access Journals (Sweden)

    Eduardo Gonçalves

    2011-04-01

    Full Text Available O objetivo deste trabalho é verificar a influência da proximidade geográfica e da proximidade tecnológica sobre a inovação regional no Brasil, medida por depósitos de patentes no período 1999-2001 para mesorregiões geográficas. Para tanto, utilizaram-se técnicas de Análise Exploratória de Dados Espaciais (AEDE e de econometria espacial. Os dados de patentes foram organizados em quatro clusters tecnológicos segundo critérios de proximidade cognitiva, como biofarmacêutico, desenvolvimento de novos materiais, bens mecânicos e de consumo e tecnologias eletroeletrônicas, revelando um padrão de concentração da atividade tecnológica em poucas mesorregiões brasileiras. Além disso, foi calculada a medida de proximidade tecnológica de Jaffe para ponderar a vizinhança geográfica pelo grau de similaridade tecnológica das mesorregiões. Os resultados confirmam a hipótese de transbordamentos de conhecimento mediados tecnológica e geograficamente.The aim of this paper is to determine the influence of technological proximity and geographical proximity on Brazilian regional innovation, measured by patent applications over the period 1999-2001 for Brazilian geographical mesoregions. First, the paper undertakes an Exploratory Spatial Data Analysis (ESDA and then uses spatial econometric techniques. According with procedures based on cognitive proximity the patent data are organized into four technological clusters such as chemical and bio-pharmaceutical, new materials, mechanical and process technologies and electrical and electronic technologies. The four aforementioned clusters exhibit a concentrated regional pattern of technological activity over few Brazilian mesoregions. Moreover, the paper uses a Jaffe's measure of technological distance in order to construct a matrix in which the technological similarity is weighted by the geographical proximity. The results corroborate the hypothesis of geographically and technologically

  18. Influence of inflammation-mediated osteopenia on the regional acceleratory phenomenon and the systemic acceleratory phenomenon during healing of a bone defect in the rat.

    Science.gov (United States)

    Schilling, T; Müller, M; Minne, H W; Ziegler, R

    1998-08-01

    We have previously shown that restoration of a local bone defect in the rat not only leads to a regional acceleratory phenomenon (RAP), but also to a systemic acceleration of osteogenesis (SAP) at distant sites of the skeleton. In this study, we investigated whether specific inhibition of osteoblasts would affect the local RAP and the systemic acceleratory phenomenon (SAP) healing sites. Systemic inhibition of osteoblasts was induced by inflammation-mediated osteopenia (IMO), a nonspecific type of inflammation initiated by s.c. injections of sterile talc. A drill hole defect 1.2 mm in diameter was performed at the midshaft of the left tibia of female rats. On day 7, during the formation phase of the local healing process, IMO did not influence the number of osteoblasts or the bone volume in the marrow cavity of the local healing site, whereas it did lead to a significant reduction of osteoblast number and bone volume at the systemic site (subepiphyseal spongiosa of the tibia). By contrast, on days 14 and 21, during the resorption phase of bone healing. IMO led to a significant reduction in both osteoblast number and bone volume in the marrow cavity of the local healing site. At the same time, however, it did not influence the cortical area of the bone defect where newly formed bone is needed to ensure mechanical stability. In summary, our model of bone healing reveals that a humoral noxious osteoblast stimulus such as IMO is able to inhibit systemically osteoblasts stimulated by SAP, whereas it is not able to inhibit osteoblasts either from producing woven bone during a RAP or from producing bone that is needed to mechanically stabilize a defect. PMID:9685523

  19. Coastal ocean variability in the US Pacific Northwest region: seasonal patterns, winter circulation, and the influence of the 2009-2010 El Niño

    Science.gov (United States)

    Durski, Scott M.; Kurapov, Alexander L.; Allen, John S.; Kosro, P. Michael; Egbert, Gary D.; Shearman, R. Kipp; Barth, John A.

    2015-12-01

    A 2-km horizontal resolution ocean circulation model is developed for a large coastal region along the US Pacific Northwest (34-50N) to study how continental shelf, slope, and interior ocean variability influence each other. The model has been run for the time period September 2008-May 2011, driven by realistic surface momentum and heat fluxes obtained from an atmospheric model and lateral boundary conditions obtained from nesting in a global ocean model. The solution compares favorably to satellite measurements of sea surface temperature and sea surface height, observations of surface currents by high-frequency radars, mooring temperature time series, and glider temperature and salinity sections. The analysis is focused on the seasonal response of the coastal ocean with particular emphasis on the winter circulation patterns which have previously garnered relatively little attention. Interannual variability is examined through a comparison of the 2009-2010 winter influenced by El Niño and the winters in the preceding and following years. Strong northward winds combined with reduced surface cooling along the coast north of Cape Mendocino (40.4N) in winter 2009-2010, resulting in a vigorous downwelling season, characterized by relatively energetic northward currents and warmer ocean temperatures over the continental shelf and upper slope. An analysis of the time variability of the volume-averaged temperature and salinity in a coastal control volume (CV), that extends from 41 to 47N and offshore from the coast to the 200-m isobath, clearly shows relevant integrated characteristics of the annual cycle and the transitions between winter shelf circulation forced by northward winds and the summer circulation driven primarily by southward, upwelling-favorable winds. The analysis also reveals interesting interannual differences in these characteristics. In particular, the CV volume-average temperature remains notably warmer during January-March 2010 of the El Niño winter.

  20. Factors influencing career choice after initial training in surgery.

    LENUS (Irish Health Repository)

    McHugh, Seamus

    2012-02-01

    INTRODUCTION: Irish general surgery faces a recruitment crisis with only 87 of 145 (60%) basic surgical training (BST) places filled in 2009. We assessed basic surgical trainees to identify objective, and potentially modifiable, factors that influence ultimate recruitment into a general surgical career. METHODS: Candidates commencing BST training during a 5-year period between 2004 and 2008 were included in a quantitative study. In addition a total of 2,536 candidates, representing all those who commenced surgical training in Ireland since 1960 were identified through the Royal College of Surgeons in Ireland (RCSI) database and invited to complete an online survey. Statistical analysis was performed using SPSS version 15, with p < 0.05 considered significant. RESULTS: During the 5-year quantitative study period there were 381 BST trainees. Gender was a significant predictor of career choice with women more likely to ultimately choose a nonsurgical career after initial surgical training (p = 0.049). Passing surgical membership examinations (MRCS) also was predictive of remaining in surgery (p = 0.005). Training region was not a significant predictor of ultimate career choice. There were 418 survey respondents. The influence of role models was most commonly cited as influencing candidates in choosing to commence surgical training. Candidates who rated "academic opportunity" (p = 0.023) and "intellectual challenge" (p = 0.047) as factors that influenced their decision to commence surgical training were more likely to ultimately continue their careers in a surgical speciality. CONCLUSIONS: This study describes the career pathway of surgical trainees and confirms the importance of academic achievement in discriminating between candidates applying for surgical training schemes.

  1. Influence of quantum degeneracy and regeneration on the performance of Bose-Stirling refrigeration-cycles operated in different temperature regions

    International Nuclear Information System (INIS)

    The Stirling refrigeration cycle using an ideal Bose-gas as the working substance is called the Bose-Stirling refrigeration cycle, which is different from other thermodynamic cycles such as the Carnot cycle, Ericsson cycle, Brayton cycle, Otto cycle, Diesel cycle and Atkinson cycle working with an ideal Bose gas and may be operated across the critical temperature of Bose-Einstein condensation of the Bose system. The performance of the cycle is investigated, based on the equation of state of an ideal Bose gas. The inherent regenerative losses of the cycle are considered and the coefficient of performance and the amount of refrigeration of the cycle are calculated. The results obtained here are compared with those derived from the classical Stirling refrigeration cycle, using an ideal gas as the working substance. The influence of quantum degeneracy and inherent regenerative losses on the performance of the Bose Stirling refrigeration cycle operated in different temperature regions is discussed in detail, and consequently, general performance characteristics of the cycle are revealed

  2. The influence of Corotating Interaction Region (CIR) driven geomagnetic storms on the development of equatorial plasma bubbles (EPBs) over wide range of longitudes

    Science.gov (United States)

    Tulasi Ram, S.; Kumar, Sandeep; Su, S.-Y.; Veenadhari, B.; Ravindran, Sudha

    2015-01-01

    Recurrent high speed solar wind streams from coronal holes on the Sun are more frequent and Geoeffective during the declining phase of solar cycle which interact with the ambient solar wind leading the formation of Corotating Interaction Regions (CIRs) in the interplanetary medium. These CIR-High Speed Stream (HSS) structures of enhanced density and magnetic fields, when they impinge up on the Earth's magnetosphere, can cause recurrent geomagnetic storms in the Geospace environment. In this study, we investigate the influence of two CIR-driven recurrent geomagnetic storms on the equatorial and low-latitude ionosphere in the context of the development of equatorial plasma bubbles over Indian and Asian longitudes. The results consistently indicate that prompt penetration of eastward electric fields into equatorial and low-latitudes under southward IMF Bz can occur even during the CIR-driven storms. Further, the penetration of eastward electric fields augments the evening pre-reversal enhancement and triggers the development of EPBs over wide longitudinal sectors where the local post-sunset hours coincide with the main phase of the storm. Similar results that are consistently observed during both the CIR-driven geomagnetic storms are reported and discussed in this paper.

  3. Influence of runoff, high frequency atmospheric forcing and model resolution on deep water mass formation regions and Atlantic Meridional Overturning Circulation, from a numerical model.

    Science.gov (United States)

    Garcia Quintana, Yarisbel; Courtois, Peggy; Hu, Xianmin; Pennelly, Clark; Myers, Paul G.

    2016-04-01

    Water mass formation regions act as windows to the deep ocean where surface waters are transformed to intermediate and deep waters. Within the North Atlantic, Labrador Sea Water (LSW) is convectively produced in the Labrador Sea while in the Nordic Seas the source waters for Denmark Strait Overflow Water (DSOW) and Iceland-Scotland Overflow Water (NEADW) are formed. They are the main components of the North Atlantic Deep Water (NADW) which forms the lower limb of the Atlantic Meridional Overturning Circulation (AMOC). We explore the changes of the LSW formation rates and in AMOC strength as consequence of runoff glacial melt, high frequency atmospheric forcing influence and variations in model's resolution. We use 1/4° resolution Arctic and Northern Hemisphere Atlantic (ANHA4) configuration from the Nucleus for European Modelling of the Ocean (NEMO) model. A nest using ANHA4 and the Adaptive Grid Refinement in FORTRAN (AGRIF) package was used to increase the resolution to 1/12° in the sub-polar gyre. The formation rate is calculated based upon a kinematic subduction approach where the exchange through the dynamic mixed layer base is calculated based on shallowing and deepening in the mixed layer, and convergence of horizontal transport into or out of the mixed layer. Lastly we use a Lagrangian tool (Ariane) to track the path of the DSOW and the NEADW from their formation source.

  4. Lidar Ratio Derived for Pure Dust Aerosols: Multi-Year Micro Pulse Lidar Observations in a Saharan Dust-Influenced Region

    Science.gov (United States)

    Córdoba-Jabonero, Carmen; Adame, José Antonio; Campbell, James R.; Cuevas, Emilio; Díaz, Juan Pedro; Expósito, Francisco; Gil-Ojeda, Manuel

    2016-06-01

    A seasonal distribution of the Lidar Ratio (LR, extinction-to-backscattering coefficient ratio) for pure Saharan dust particles has been achieved. Simultaneous MPLNET/Micro Pulse lidar measurements in synergy with AERONET sun-photometer data were collected in the Tenerife area, a Saharan dust-influenced region, from June 2007 to November 2009. Dusty cases were mostly observed in summertime (71.4 % of total dusty cases). No differences were found among the LR values derived for spring, summertime and autumn times (a rather consistent seasonally averaged LR value of 57 sr is found). In wintertime, however, a higher mean LR is derived (65 sr), associated likely with a potential contamination from fine biomass burning particles coming from Sahel area during wintertime deforestation fires period. Results, obtained from a free-tropospheric pristine station (AEMET/Izaña Observatory) under Saharan dust intrusion occurrence, provide a more realistic perspective about LR values to be used in elastic lidar-derived AOD inversion for Saharan pure dust particles, and hence in improving CALIPSO AOD retrievals.

  5. Identifying False Alarms in the Kepler Planet Candidate Catalog

    CERN Document Server

    Mullally, F; Thompson, Susan E; Christiansen, Jessie; Burke, Christopher; Clarke, Bruce D; Haas, Michael R

    2016-01-01

    We present a new automated method to identify instrumental features masquerading as small, long period planets in the \\kepler\\ planet candidate catalog. These systematics, mistakenly identified as planet transits, can have a strong impact on occurrence rate calculations because they cluster in a region of parameter space where Kepler's sensitivity to planets is poor. We compare individual transit-like events to a variety of models of real transits and systematic events, and use a Bayesian Information Criterion to evaluate the likelihood that each event is real. We describe our technique and test its performance on simulated data. Results from this technique are incorporated in the \\kepler\\ Q1-17 DR24 planet candidate catalog of \\citet{Coughlin15}.

  6. A novel live-attenuated vaccine candidate for mayaro Fever.

    Directory of Open Access Journals (Sweden)

    William J Weise

    2014-08-01

    Full Text Available Mayaro virus (MAYV is an emerging, mosquito-borne alphavirus that causes a dengue-like illness in many regions of South America, and which has the potential to urbanize. Because no specific treatment or vaccine is available for MAYV infection, we capitalized on an IRES-based approach to develop a live-attenuated MAYV vaccine candidate. Testing in infant, immunocompetent as well as interferon receptor-deficient mice demonstrated a high degree of attenuation, strong induction of neutralizing antibodies, and efficacy against lethal challenge. This vaccine strain was also unable to infect mosquito cells, a major safety feature for a live vaccine derived from a mosquito-borne virus. Further preclinical development of this vaccine candidate is warranted to protect against this important emerging disease.

  7. Identifying False Alarms in the Kepler Planet Candidate Catalog

    Science.gov (United States)

    Mullally, F.; Coughlin, Jeffery L.; Thompson, Susan E.; Christiansen, Jessie; Burke, Christopher; Clarke, Bruce D.; Haas, Michael R.

    2016-07-01

    We present a new automated method to identify instrumental features masquerading as small, long-period planets in the Kepler planet candidate catalog. These systematics, mistakenly identified as planet transits, can have a strong impact on occurrence rate calculations because they cluster in a region of parameter space where Kepler’s sensitivity to planets is poor. We compare individual transit-like events to a variety of models of real transits and systematic events and use a Bayesian information criterion to evaluate the likelihood that each event is real. We describe our technique and test its performance on simulated data. Results from this technique are incorporated in the Kepler Q1–Q17 DR24 planet candidate catalog of Coughlin et al.

  8. Simulating secondary organic aerosol in a regional air quality model using the statistical oxidation model - Part 1: Assessing the influence of constrained multi-generational ageing

    Science.gov (United States)

    Jathar, S. H.; Cappa, C. D.; Wexler, A. S.; Seinfeld, J. H.; Kleeman, M. J.

    2016-02-01

    tested. Consequently, the use of low and high NOx yields perturbs SOA concentrations by a factor of two and are probably a much stronger determinant in 3-D models than multi-generational oxidation. While total predicted SOA mass is similar for the SOM and two-product models, the SOM model predicts increased SOA contributions from anthropogenic (alkane, aromatic) and sesquiterpenes and decreased SOA contributions from isoprene and monoterpene relative to the two-product model calculations. The SOA predicted by SOM has a much lower volatility than that predicted by the traditional model, resulting in better qualitative agreement with volatility measurements of ambient OA. On account of its lower-volatility, the SOA mass produced by SOM does not appear to be as strongly influenced by the inclusion of oligomerization reactions, whereas the two-product model relies heavily on oligomerization to form low-volatility SOA products. Finally, an unconstrained contemporary hybrid scheme to model multi-generational oxidation within the framework of a two-product model in which ageing reactions are added on top of the existing two-product parameterization is considered. This hybrid scheme formed at least 3 times more SOA than the SOM during regional simulations as a result of excessive transformation of semi-volatile vapors into lower volatility material that strongly partitions to the particle phase. This finding suggests that these hybrid multi-generational schemes should be used with great caution in regional models.

  9. Simulating secondary organic aerosol in a regional air quality model using the statistical oxidation model – Part 1: Assessing the influence of constrained multi-generational ageing

    Directory of Open Access Journals (Sweden)

    S. H. Jathar

    2015-09-01

    perturbs SOA concentrations by a factor of two and are probably a much stronger determinant in 3-D models than constrained multi-generational oxidation. While total predicted SOA mass is similar for the SOM and two-product models, the SOM model predicts increased SOA contributions from anthropogenic (alkane, aromatic and sesquiterpenes and decreased SOA contributions from isoprene and monoterpene relative to the two-product model calculations. The SOA predicted by SOM has a much lower volatility than that predicted by the traditional model resulting in better qualitative agreement with volatility measurements of ambient OA. On account of its lower-volatility, the SOA mass produced by SOM does not appear to be as strongly influenced by the inclusion of oligomerization reactions, whereas the two-product model relies heavily on oligomerization to form low volatility SOA products. Finally, an unconstrained contemporary hybrid scheme to model multi-generational oxidation within the framework of a two-product model in which "ageing" reactions are added on top of the existing two-product parameterization is considered. This hybrid scheme formed at least three times more SOA than the SOM during regional simulations as a result of excessive transformation of semi-volatile vapors into lower volatility material that strongly partitions to the particle phase. This finding suggests that these "hybrid" multi-generational schemes should be used with great caution in regional models.

  10. An X-ray and Infrared Hunt for New Candidate Galactic OB Stars

    Science.gov (United States)

    Povich, Matthew S.; Alexander, Michael J.; Busk, Heather; Hanes, Richard J.; Feigelson, Eric; McSwain, M. Virginia; Townsley, Leisa K.

    2016-01-01

    Most young, massive OB stars produce X-ray emission through a variety of wind-driven shock processes, and individual massive stars are detectable out to several kpc distances in the Galactic plane using high-resolution imaging observations from the Chandra X-ray Observatory. We have developed a technique to identify known and new candidate OB stars by fitting model stellar atmospheres to the broadband infrared spectral energy distributions of X-ray-identified stars. Using this technique, we identified 94 candidate O- and early B-type stars in the Carina Nebula and an additional 98 candidates in 11 other Galactic Massive Star-Forming Regions. Visible-light and near-infrared follow-up spectroscopy of these candidates is ongoing, and initial results indicate that a majority of candidate massive stars will be spectroscopically confirmed as OB stars.

  11. Assessment of regional-scale primary production in terrestrial ecosystems to estimate the possible influence of future climate change on biodiversity

    Science.gov (United States)

    Noda, Hibiki; Nishina, Kazuya; Ito, Akihiko

    2015-04-01

    In recent decades, climate change including global warming has progressed worldwide and their influences on ecosystem structure and function that provide various goods and services to humans' well-being are of the greatest concerns. The ecosystem function and services are tightly coupled with the biodiversity particularly via food web and biogeochemical cycles, and here carbon is one of the central elements that also affect atmospheric CO2 concentration. Therefore mechanistic and quantitative understandings of the consequences among on-going climate change, ecosystem function, and biodiversity are urgent issues for seeking a better adaptation strategy. In order to tackle such tasks in the current environmental and ecological sciences, efforts have been made by numerous scientists and/or organizations to clarify the current status of and threats to biodiversity, responses of biogeochemical cycles to meteorological variables, and to construct climate change scenarios considering economic activities. However, to gain insights into the possible influence of climate change on biodiversity via altered ecosystem functions over broad temporal and spatial scales ranging from past to near-future periods and from landscape to global scales, further efforts to find the consequences are required, since the assessment of the influence of climate change on biodiversity is straightforward but difficult. For decades in climate change science, carbon flux between the atmosphere and terrestrial ecosystems has attracted intensive attention as it connects the atmosphere and biosphere. Carbon flux in the biosphere is not only a process of biogeochemical material flux but also is an element to drive biological and ecological processes in ecosystems via food web beginning from photosynthetic carbon fixation by plants. Therefore focusing on photosynthetic production by plants, i.e. primary production of the ecosystem, may help us to estimate the possible influence of climate change on

  12. Cattle Candidate Genes for Milk Production Traits

    OpenAIRE

    Kadlec,Tomáš

    2012-01-01

    The aim of this thesis is to make an overview of important candidate genes affecting milk yield and milk quality parameters, with an emphasis on genes associated with the quantity and quality of milk proteins and milk fat.

  13. Evaluating historical candidate genes for schizophrenia

    DEFF Research Database (Denmark)

    Farrell, M S; Werge, T; Sklar, P;

    2015-01-01

    Prior to the genome-wide association era, candidate gene studies were a major approach in schizophrenia genetics. In this invited review, we consider the current status of 25 historical candidate genes for schizophrenia (for example, COMT, DISC1, DTNBP1 and NRG1). The initial study for 24 of these...... genes explicitly evaluated common variant hypotheses about schizophrenia. Our evaluation included a meta-analysis of the candidate gene literature, incorporation of the results of the largest genomic study yet published for schizophrenia, ratings from informed researchers who have published on these...... genes, and ratings from 24 schizophrenia geneticists. On the basis of current empirical evidence and mostly consensual assessments of informed opinion, it appears that the historical candidate gene literature did not yield clear insights into the genetic basis of schizophrenia. A likely reason why...

  14. Scattering Properties of Candidate Planetary Regolith Materials

    Science.gov (United States)

    Nelson, R. M.; Smythe, W. D.; Hapke, B. W.; Hale, A. S.; Piatek, J. A.

    2001-01-01

    The laboratory investigation of the scattering properties of candidate planetary regolith materials is an important technique for understanding the physical properties of a planetary regolith. Additional information is contained in the original extended abstract.

  15. Characterization of nanoparticles as candidate reference materials

    International Nuclear Information System (INIS)

    We report the characterization of three different nanoparticles (silica, silver and multi-walled carbon nanotubes) as candidate reference material. We focus our analysis on the size distribution of those particles as measured by different microscopy techniques. (author)

  16. Characterization of nanoparticles as candidate reference materials

    Energy Technology Data Exchange (ETDEWEB)

    Martins Ferreira, E.H.; Robertis, E. de; Landi, S.M.; Gouvea, C.P.; Archanjo, B.S.; Almeida, C.A.; Araujo, J.R. de; Kuznetsov, O.; Achete, C.A., E-mail: smlandi@inmetro.gov.br [Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMETRO), Rio de Janeiro, RJ (Brazil)

    2013-07-01

    We report the characterization of three different nanoparticles (silica, silver and multi-walled carbon nanotubes) as candidate reference material. We focus our analysis on the size distribution of those particles as measured by different microscopy techniques. (author)

  17. 76 FR 4896 - Call for Candidates

    Science.gov (United States)

    2011-01-27

    ... accepted accounting principles for federal government entities. Generally, non-federal Board members are... From the Federal Register Online via the Government Publishing Office FEDERAL ACCOUNTING STANDARDS ADVISORY BOARD Call for Candidates AGENCY: Federal Accounting Standards Advisory Board. ACTION:...

  18. 76 FR 36130 - Call for Candidates

    Science.gov (United States)

    2011-06-21

    ... establish generally accepted accounting principles for federal government entities. Generally, non- federal... From the Federal Register Online via the Government Publishing Office FEDERAL ACCOUNTING STANDARDS ADVISORY BOARD Call for Candidates AGENCY: Federal Accounting Standards Advisory Board. ACTION: Request...

  19. Vaccine candidates for malaria: what's new?

    Science.gov (United States)

    Takashima, Eizo; Morita, Masayuki; Tsuboi, Takafumi

    2016-01-01

    Although it is more than a decade since the parasite genome information was obtained, standardized novel genome-wide selection/prioritization strategies for candidacy of malaria vaccine antigens are still sought. In the quest to systematically identify candidates, it is impossible to overemphasize the usefulness of wheat germ cell-free technology in expressing quality proteins for the post-genome vaccine candidate discovery. PMID:26559316

  20. Cardiac evaluation of liver transplant candidates

    Institute of Scientific and Technical Information of China (English)

    Mercedes Susan Mandell; JoAnn Lindenfeld; Mei-Yung Tsou; Michael Zimmerman

    2008-01-01

    Physicians previously thought that heart disease was rare in patients with end stage liver disease. However, recent evidence shows that the prevalence of ischemic heart disease and cardiomyopathy is increased in transplant candidates compared to most other surgical candidates. Investigators estimate that up to 26% of all liver transplant candidates have at least one critical coronary artery stenosis and that at least half of these patients will die perioperatively of cardiac complications. Cardiomyopathy also occurs in greater frequency. While all patients with advanced cardiac disease have defects in cardiac performance, a larger than expected number of patients have classical findings of dilated, restrictive and hypertropic cardiomyopathy. This may explain why up to 56% of patients suffer from hypoxemia due to pulmonary edema following transplant surgery. There is considerable controversy on how to screen transplant candidates for the presence of heart disease. Questions focus upon, which patients should be screened and what tests should be used. This review examines screening strategies for transplant candidates and details the prognostic value of common tests used to identify ischemic heart disease. We also review the physiological consequences of cardiomyopathy in transplant candidates and explore the specific syndrome of "cirrhotic cardiomyopathy".