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Sample records for candidate downstream amplifier

  1. Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer.

    Directory of Open Access Journals (Sweden)

    Kevin A Kwei

    2008-05-01

    Full Text Available Pancreatobiliary cancers have among the highest mortality rates of any cancer type. Discovering the full spectrum of molecular genetic alterations may suggest new avenues for therapy. To catalogue genomic alterations, we carried out array-based genomic profiling of 31 exocrine pancreatic cancers and 6 distal bile duct cancers, expanded as xenografts to enrich the tumor cell fraction. We identified numerous focal DNA amplifications and deletions, including in 19% of pancreatobiliary cases gain at cytoband 18q11.2, a locus uncommonly amplified in other tumor types. The smallest shared amplification at 18q11.2 included GATA6, a transcriptional regulator previously linked to normal pancreas development. When amplified, GATA6 was overexpressed at both the mRNA and protein levels, and strong immunostaining was observed in 25 of 54 (46% primary pancreatic cancers compared to 0 of 33 normal pancreas specimens surveyed. GATA6 expression in xenografts was associated with specific microarray gene-expression patterns, enriched for GATA binding sites and mitochondrial oxidative phosphorylation activity. siRNA mediated knockdown of GATA6 in pancreatic cancer cell lines with amplification led to reduced cell proliferation, cell cycle progression, and colony formation. Our findings indicate that GATA6 amplification and overexpression contribute to the oncogenic phenotypes of pancreatic cancer cells, and identify GATA6 as a candidate lineage-specific oncogene in pancreatobiliary cancer, with implications for novel treatment strategies.

  2. Spectroscopic and laser properties of Er3+ doped fluoro-phosphate glasses as promising candidates for broadband optical fiber lasers and amplifiers

    International Nuclear Information System (INIS)

    Highlights: • Erbium doped different fluoro-phosphate glasses are prepared and characterized. • Spectroscopic properties have been determined using Judd–Ofelt and Mc-Cumber theory. • Prominent laser transition Er3+:4I13/2 → 4I15/2 is observed at 1.53 μm. - Abstract: Different fluoro-phosphate glasses doped with 0.5 mol% Er3+ doped are prepared by melt quenching method. Both structural and spectroscopic properties have been characterized in order to evaluate their potential as both laser source and amplifier materials. Optical absorption measurements are carried out and analyzed through Judd–Ofelt and Mc-Cumber theories where spectroscopic parameters such as intensity parameters Ωl (λ = 2,4,6), transition probabilities, radiative lifetimes, stimulated absorption cross-sections and emission cross-sections at 1.5 μm have been evaluated for Er3+ doped different fluorophosphate glasses. The various luminescence and gain properties are explained from photoluminescence studies. The decay curve analysis have been done for obtaining the decay time constants of Er3+ excited level 4I13/2 in all the fluoro-phosphate glasses. The obtained results of each glass matrix are compared with the equivalent parameters for several other host glasses. These fluoro-phosphate glasses are found to be suitable candidates for laser and amplifier applications

  3. Spectroscopic and laser properties of Er{sup 3+} doped fluoro-phosphate glasses as promising candidates for broadband optical fiber lasers and amplifiers

    Energy Technology Data Exchange (ETDEWEB)

    Babu, S. [Department of Physics, Sri Venkateswara University, Tirupati 517 502, A.P. (India); Seshadri, M. [Institute of Physics, University of Campinas, UNICAMP, P.O. Box 6165, Campinas 13083-970 (Brazil); Reddy Prasad, V. [Department of Physics, Sri Venkateswara University, Tirupati 517 502, A.P. (India); Ratnakaram, Y.C., E-mail: ratnakaramsvu@gmail.com [Department of Physics, Sri Venkateswara University, Tirupati 517 502, A.P. (India)

    2015-10-15

    Highlights: • Erbium doped different fluoro-phosphate glasses are prepared and characterized. • Spectroscopic properties have been determined using Judd–Ofelt and Mc-Cumber theory. • Prominent laser transition Er{sup 3+}:{sup 4}I{sub 13/2} → {sup 4}I{sub 15/2} is observed at 1.53 μm. - Abstract: Different fluoro-phosphate glasses doped with 0.5 mol% Er{sup 3+} doped are prepared by melt quenching method. Both structural and spectroscopic properties have been characterized in order to evaluate their potential as both laser source and amplifier materials. Optical absorption measurements are carried out and analyzed through Judd–Ofelt and Mc-Cumber theories where spectroscopic parameters such as intensity parameters Ω{sub l} (λ = 2,4,6), transition probabilities, radiative lifetimes, stimulated absorption cross-sections and emission cross-sections at 1.5 μm have been evaluated for Er{sup 3+} doped different fluorophosphate glasses. The various luminescence and gain properties are explained from photoluminescence studies. The decay curve analysis have been done for obtaining the decay time constants of Er{sup 3+} excited level {sup 4}I{sub 13/2} in all the fluoro-phosphate glasses. The obtained results of each glass matrix are compared with the equivalent parameters for several other host glasses. These fluoro-phosphate glasses are found to be suitable candidates for laser and amplifier applications.

  4. Operational amplifiers

    CERN Document Server

    Dostal, Jiri

    1993-01-01

    This book provides the reader with the practical knowledge necessary to select and use operational amplifier devices. It presents an extensive treatment of applications and a practically oriented, unified theory of operational circuits.Provides the reader with practical knowledge necessary to select and use operational amplifier devices. Presents an extensive treatment of applications and a practically oriented, unified theory of operational circuits

  5. Gain ranging amplifier

    International Nuclear Information System (INIS)

    A gain ranging amplifier system is provided for use in the acquisition of data. Voltage offset compensation is utilized to correct errors in the gain ranging amplifier system caused by thermal drift and temperature dependent voltage offsets, both of which are associated with amplifiers in the gain ranging amplifier system

  6. Downstream in Mawrth Valles

    Science.gov (United States)

    2005-01-01

    [figure removed for brevity, see original site] The THEMIS VIS camera is capable of capturing color images of the Martian surface using five different color filters. In this mode of operation, the spatial resolution and coverage of the image must be reduced to accommodate the additional data volume produced from using multiple filters. To make a color image, three of the five filter images (each in grayscale) are selected. Each is contrast enhanced and then converted to a red, green, or blue intensity image. These three images are then combined to produce a full color, single image. Because the THEMIS color filters don't span the full range of colors seen by the human eye, a color THEMIS image does not represent true color. Also, because each single-filter image is contrast enhanced before inclusion in the three-color image, the apparent color variation of the scene is exaggerated. Nevertheless, the color variation that does appear is representative of some change in color, however subtle, in the actual scene. Note that the long edges of THEMIS color images typically contain color artifacts that do not represent surface variation. This false color image is from further downstream in Mawrth Valles than yesterday's image. The channel here is at the end of the vallis. This image was collected during the Northern Spring season. Image information: VIS instrument. Latitude 26.7, Longitude 340.2 East (19.8 West). 37 meter/pixel resolution. Note: this THEMIS visual image has not been radiometrically nor geometrically calibrated for this preliminary release. An empirical correction has been performed to remove instrumental effects. A linear shift has been applied in the cross-track and down-track direction to approximate spacecraft and planetary motion. Fully calibrated and geometrically projected images will be released through the Planetary Data System in accordance with Project policies at a later time. NASA's Jet Propulsion Laboratory manages the 2001 Mars Odyssey

  7. Portable musical instrument amplifier

    Energy Technology Data Exchange (ETDEWEB)

    Christian, David E. (Danbury, CT)

    1990-07-24

    The present invention relates to a musical instrument amplifier which is particularly useful for electric guitars. The amplifier has a rigid body for housing both the electronic system for amplifying and processing signals from the guitar and the system's power supply. An input plug connected to and projecting from the body is electrically coupled to the signal amplifying and processing system. When the plug is inserted into an output jack for an electric guitar, the body is rigidly carried by the guitar, and the guitar is operatively connected to the electrical amplifying and signal processing system without use of a loose interconnection cable. The amplifier is provided with an output jack, into which headphones are plugged to receive amplified signals from the guitar. By eliminating the conventional interconnection cable, the amplifier of the present invention can be used by musicians with increased flexibility and greater freedom of movement.

  8. High voltage distributed amplifier

    Science.gov (United States)

    Willems, D.; Bahl, I.; Wirsing, K.

    1991-12-01

    A high-voltage distributed amplifier implemented in GaAs MMIC technology has demonstrated good circuit performance over at least two octave bandwidth. This technique allows for very broadband amplifier operation with good efficiency in satellite, active-aperture radar, and battery-powered systems. Also, by increasing the number of FETs, the amplifier can be designed to match different voltage rails. The circuit does require a small amount of additional chip size over conventional distributed amplifiers but does not require power dividers or additional matching networks. This circuit configuration should find great use in broadband power amplifier design.

  9. Arabic downstream crushes competition; Arabische downstream verpletterd concurrentie

    Energy Technology Data Exchange (ETDEWEB)

    Widdershoven, C. [Capgemini International, Utrecht (Netherlands)

    2007-07-01

    Oil producers in the Middle East have enormous advantages while the costs for resources are very low. The petrochemical industry in this region shows a considerable growth. The question, however, is whether this situation will continue for a long time. [Dutch] Veel downstream-bedrijven in het Westen hebben hun activiteiten afgebouwd wegens zeer lage of negatieve winstmarges. Op hetzelfde moment is er een exponentiele groei van de downstream-sector te zien in het Midden-Oosten, West-Afrika en Azie. De komende jaren wordt er wereldwijdvoor meer dan zeshonderd miljard dollar aan nieuwe downstream-projecten op poten gezet. Een substantieel deel van deze projecten is in het Midden-Oosten gepland, waarbij Saudi-Arabie, Qatar, Verenigde Arabische Emiraten, Iran en Egypte het voortouw nemen. De Arabische nationale olie- en gasmaatschappijen - Saudi Aramco, Qatargas, NIOC and EGPC - onderkennen dat het strategisch en financieel interessant is om deze sector in handen te krijgen.

  10. The restructuring of Shell Downstream; La restructuration de Shell Downstream

    Energy Technology Data Exchange (ETDEWEB)

    Maxwell, F.

    2005-01-15

    To facing a more and more competitive environment, the Group Shell began a restructuring. While the group was organized on horizontal national lines, it is creating today an integrated downstream activity. The word of this restructuring is profit. (A.L.B.)

  11. Oscillators and operational amplifiers

    DEFF Research Database (Denmark)

    Lindberg, Erik

    2005-01-01

    A generalized approach to the design of oscillators using operational amplifiers as active elements is presented. A piecewise-linear model of the amplifier is used so that it make sense to investigate the eigenvalues of the Jacobian of the differential equations. The characteristic equation...... of the general circuit is derived. The dynamic nonlinear transfer characteristic of the amplifier is investigated. Examples of negative resistance oscillators are discussed....

  12. Downstream fining - a literature review -

    NARCIS (Netherlands)

    Frings, R.M.

    2004-01-01

    In this report a detailed overview is given of the present knowledge about downstream fining. The influence of abrasion (chapter 2), selective transport (chapter 3), sediment addition, extraction and redistribution (chapter 4) is described and discussed. Then some attention is attained to a very str

  13. Continuous downstream processing of biopharmaceuticals.

    Science.gov (United States)

    Jungbauer, Alois

    2013-08-01

    Continuous manufacturing has been applied in many different industries but has been pursued reluctantly in biotechnology where the batchwise process is still the standard. A shift to continuous operation can improve productivity of a process and substantially reduce the footprint. Continuous operation also allows robust purification of labile biomolecules. A full set of unit operations is available to design continuous downstream processing of biopharmaceuticals. Chromatography, the central unit operation, is most advanced in respect to continuous operation. Here, the problem of 'batch' definition has been solved. This has also paved the way for implementation of continuous downstream processing from a regulatory viewpoint. Economic pressure, flexibility, and parametric release considerations will be the driving force to implement continuous manufacturing strategies in future.

  14. Electrospun Amplified Fiber Optics

    OpenAIRE

    Morello, Giovanni; Camposeo, Andrea; Moffa, Maria; Pisignano, Dario

    2015-01-01

    A lot of research is focused on all-optical signal processing, aiming to obtain effective alternatives to existing data transmission platforms. Amplification of light in fiber optics, such as in Erbium-doped fiber amplifiers, is especially important for an efficient signal transmission. However, the complex fabrication methods, involving high-temperature processes performed in highly pure environment, slow down the fabrication and make amplified components expensive with respect to an ideal, ...

  15. RF Power Amplifier Analysis

    Directory of Open Access Journals (Sweden)

    M. Lokay

    1993-04-01

    Full Text Available The special program is presented for the demonstration of RF power transistor amplifiers for the purposes of the high-school education in courses of radio transmitters. The program is written in Turbo Pascal 6. 0 and enables to study the waveforms in selected points of the amplifier and to draw the trajectories of the working point in a plot of output transistor characteristics.

  16. Noise in Optical Amplifiers

    DEFF Research Database (Denmark)

    Jeppesen, Palle

    1997-01-01

    Noise in optical amplifiers is discussed on the basis of photons and electromagntic fields. Formulas for quantum noise from spontaneous emission, signal-spontaneous beat noise and spontaneous-spontaneous beat noise are derived.......Noise in optical amplifiers is discussed on the basis of photons and electromagntic fields. Formulas for quantum noise from spontaneous emission, signal-spontaneous beat noise and spontaneous-spontaneous beat noise are derived....

  17. Operational optimization in the downstream; Otimizacao operacional no downstream

    Energy Technology Data Exchange (ETDEWEB)

    Silberman, Luis; Cunha, Filipe Silveira Ramos da [Petroleo Ipiranga, Porto Alegre, RS (Brazil)

    2004-07-01

    On the present competitive down stream's market, there is a great necessity of optimization aiming to guarantee the best price and quality of our clients. Our goal is to attend these expectations while we guarantee an efficient operation. The greatest question is how far we are from the ideal model. This way, a lot of projects have been executed during the last years aiming the operational optimization of all our activities. We divide the projects in 4 areas: Logistic (new modals distribution), Transport (transport optimization - quality and more deliveries with less trucks), Client Support (Internet Ipiranga and Support Center), Distribution Terminals Productivity (automation and environment). This work intend to present our ideal, perfect and complete Downstream Operation model. We will talk about how close we are of this ideal model and we will present the projects that we had already developed and implanted on the automation of the terminals and the logistics area. (author)

  18. Electrospun amplified fiber optics.

    Science.gov (United States)

    Morello, Giovanni; Camposeo, Andrea; Moffa, Maria; Pisignano, Dario

    2015-03-11

    All-optical signal processing is the focus of much research aiming to obtain effective alternatives to existing data transmission platforms. Amplification of light in fiber optics, such as in Erbium-doped fiber amplifiers, is especially important for efficient signal transmission. However, the complex fabrication methods involving high-temperature processes performed in a highly pure environment slow the fabrication process and make amplified components expensive with respect to an ideal, high-throughput, room temperature production. Here, we report on near-infrared polymer fiber amplifiers working over a band of ∼20 nm. The fibers are cheap, spun with a process entirely carried out at room temperature, and shown to have amplified spontaneous emission with good gain coefficients and low levels of optical losses (a few cm(-1)). The amplification process is favored by high fiber quality and low self-absorption. The found performance metrics appear to be suitable for short-distance operations, and the large variety of commercially available doping dyes might allow for effective multiwavelength operations by electrospun amplified fiber optics.

  19. A micropower electrocardiogram amplifier.

    Science.gov (United States)

    Fay, L; Misra, V; Sarpeshkar, R

    2009-10-01

    We introduce an electrocardiogram (EKG) preamplifier with a power consumption of 2.8 muW, 8.1 muVrms input-referred noise, and a common-mode rejection ratio of 90 dB. Compared to previously reported work, this amplifier represents a significant reduction in power with little compromise in signal quality. The improvement in performance may be attributed to many optimizations throughout the design including the use of subthreshold transistor operation to improve noise efficiency, gain-setting capacitors versus resistors, half-rail operation wherever possible, optimal power allocations among amplifier blocks, and the sizing of devices to improve matching and reduce noise. We envision that the micropower amplifier can be used as part of a wireless EKG monitoring system powered by rectified radio-frequency energy or other forms of energy harvesting like body vibration and body heat. PMID:23853270

  20. A vircator amplifier

    International Nuclear Information System (INIS)

    A cavity vircator has demonstrated that formation of a virtual cathode in a cavity can improve microwave production efficiency and narrow the radiation bandwidth. When the virtual cathode radiates the microwave fields grow from noise. For each cavity, there is only one or a limited number of allowable modes for a given frequency. In this paper, a novel device - a vircator amplifier is described. The device consists of a relativistic magnetron and a cavity vircator with both devices powered by a 1 MeV, 3 Ω, 65 ns FWHM pulser. The idea is to inject a signal from the magnetron before and during virtual cathode formation in a cavity. The injected signal should lock the frequency and enhance electron bunching and therefore improve efficiency further. Experiments underway to evaluate the amplifier operating characteristics are discussed. The applicability of vircator amplifiers to the next generation of high-power microwave devices are addressed

  1. Fourier plane image amplifier

    Science.gov (United States)

    Hackel, L.A.; Hermann, M.R.; Dane, C.B.; Tiszauer, D.H.

    1995-12-12

    A solid state laser is frequency tripled to 0.3 {micro}m. A small portion of the laser is split off and generates a Stokes seed in a low power oscillator. The low power output passes through a mask with the appropriate hole pattern. Meanwhile, the bulk of the laser output is focused into a larger stimulated Brillouin scattering (SBS) amplifier. The low power beam is directed through the same cell in the opposite direction. The majority of the amplification takes place at the focus which is the fourier transform plane of the mask image. The small holes occupy large area at the focus and thus are preferentially amplified. The amplified output is now imaged onto the multichip module where the holes are drilled. Because of the fourier plane amplifier, only about 1/10th the power of a competitive system is needed. This concept allows less expensive masks to be used in the process and requires much less laser power. 1 fig.

  2. Helical Fiber Amplifier

    Science.gov (United States)

    Koplow, Jeffrey P.; Kliner, Dahy; Goldberg, Lew

    2002-12-17

    A multi-mode gain fiber is provided which affords substantial improvements in the maximum pulse energy, peak power handling capabilities, average output power, and/or pumping efficiency of fiber amplifier and laser sources while maintaining good beam quality (comparable to that of a conventional single-mode fiber source). These benefits are realized by coiling the multimode gain fiber to induce significant bend loss for all but the lowest-order mode(s).

  3. Electronic amplifiers for automatic compensators

    CERN Document Server

    Polonnikov, D Ye

    1965-01-01

    Electronic Amplifiers for Automatic Compensators presents the design and operation of electronic amplifiers for use in automatic control and measuring systems. This book is composed of eight chapters that consider the problems of constructing input and output circuits of amplifiers, suppression of interference and ensuring high sensitivity.This work begins with a survey of the operating principles of electronic amplifiers in automatic compensator systems. The succeeding chapters deal with circuit selection and the calculation and determination of the principal characteristics of amplifiers, as

  4. Simplified design of IC amplifiers

    CERN Document Server

    Lenk, John

    1996-01-01

    Simplified Design of IC Amplifiers has something for everyone involved in electronics. No matter what skill level, this book shows how to design and experiment with IC amplifiers. For experimenters, students, and serious hobbyists, this book provides sufficient information to design and build IC amplifier circuits from 'scratch'. For working engineers who design amplifier circuits or select IC amplifiers, the book provides a variety of circuit configurations to make designing easier.Provides basics for all phases of practical design.Covers the most popular forms for amplif

  5. Flow downstream of the heliospheric terminal shock - Magnetic field kinematics

    Science.gov (United States)

    Nerney, S.; Suess, S. T.; Schmahl, E. J.

    1991-01-01

    A kinematic model of the interplanetary magnetic field in the heliosheath beyond the solar wind terminal shock is presented in order to evaluate the possible importance of MHD effects in that region of space. The need for this evaluation arises because the interplanetary magnetic field is compressed across the terminal shock and further amplified by the decreasing flow speed beyond the shock. Streamlines which approach the stagnation point before turning in the downstream direction lead to the strongest effects due to the extreme slowing of the solar wind and consequent compression of the embedded magnetic field. The magnetic volume force therefore cannot be neglected on streamlines that approach the heliopause in the upstream direction, where the volume containing them is a large fraction of the overall of the heliosheath in the upstream direction. The increase in the magnetic pressure may act to bring the upstream terminal shock significantly closer to the sun, potentially reconciling a conflict between models and observations.

  6. CNOOC Advancing into Downstream of Petroleum Industry

    Institute of Scientific and Technical Information of China (English)

    1997-01-01

    @@ "China National Offshore Oil Corporation is starting to expand its business into the downstream sector after making achievements continuously in exploration and development," Wang Yan, president of the corporation,told reporter in an interview, adding that the downstream sector is the third development stage for China National Offshore Oil Corporation (CNOOC).

  7. Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target.

    Science.gov (United States)

    Watanabe, Hideo; Francis, Joshua M; Woo, Michele S; Etemad, Banafsheh; Lin, Wenchu; Fries, Daniel F; Peng, Shouyong; Snyder, Eric L; Tata, Purushothama Rao; Izzo, Francesca; Schinzel, Anna C; Cho, Jeonghee; Hammerman, Peter S; Verhaak, Roel G; Hahn, William C; Rajagopal, Jayaraj; Jacks, Tyler; Meyerson, Matthew

    2013-01-15

    The NKX2-1 transcription factor, a regulator of normal lung development, is the most significantly amplified gene in human lung adenocarcinoma. To study the transcriptional impact of NKX2-1 amplification, we generated an expression signature associated with NKX2-1 amplification in human lung adenocarcinoma and analyzed DNA-binding sites of NKX2-1 by genome-wide chromatin immunoprecipitation. Integration of these expression and cistromic analyses identified LMO3, itself encoding a transcription regulator, as a candidate direct transcriptional target of NKX2-1. Further cistromic and overexpression analyses indicated that NKX2-1 can cooperate with the forkhead box transcription factor FOXA1 to regulate LMO3 gene expression. RNAi analysis of NKX2-1-amplified cells compared with nonamplified cells demonstrated that LMO3 mediates cell survival downstream from NKX2-1. Our findings provide new insight into the transcriptional regulatory network of NKX2-1 and suggest that LMO3 is a transcriptional signal transducer in NKX2-1-amplified lung adenocarcinomas. PMID:23322301

  8. Wideband amplifier design

    CERN Document Server

    Hollister, Allen L

    2007-01-01

    In this book, the theory needed to understand wideband amplifier design using the simplest models possible will be developed. This theory will be used to develop algebraic equations that describe particular circuits used in high frequency design so that the reader develops a ""gut level"" understanding of the process and circuit. SPICE and Genesys simulations will be performed to show the accuracy of the algebraic models. By looking at differences between the algebraic equations and the simulations, new algebraic models will be developed that include parameters originally left out of the model

  9. Building valve amplifiers

    CERN Document Server

    Jones, Morgan

    2013-01-01

    Building Valve Amplifiers is a unique hands-on guide for anyone working with tube audio equipment--as an electronics hobbyist, audiophile or audio engineer. This 2nd Edition builds on the success of the first with technology and technique revisions throughout and, significantly, a major new self-build project, worked through step-by-step, which puts into practice the principles and techniques introduced throughout the book. Particular attention has been paid to answering questions commonly asked by newcomers to the world of the valve, whether audio enthusiasts tackling their first build or

  10. Universal Signal Conditioning Amplifier

    Science.gov (United States)

    Kinney, Frank

    1997-01-01

    The Technological Research and Development Authority (TRDA) and NASA-KSC entered into a cooperative agreement in March of 1994 to achieve the utilization and commercialization of a technology development for benefiting both the Space Program and U.S. industry on a "dual-use basis". The technology involved in this transfer is a new, unique Universal Conditioning Amplifier (USCA) used in connection with various types of transducers. The project was initiated in partnership with I-Net Corporation, Lockheed Martin Telemetry & Instrumentation (formerly Loral Test and Information Systems) and Brevard Community College. The project consists of designing, miniaturizing, manufacturing, and testing an existing prototype of USCA that was developed for NASA-KSC by the I-Net Corporation. The USCA is a rugged and field-installable self (or remotely)- programmable amplifier that works in combination with a tag random access memory (RAM) attached to various types of transducers. This summary report comprises performance evaluations, TRDA partnership tasks, a project summary, project milestones and results.

  11. DIAMOND AMPLIFIED PHOTOCATHODES.

    Energy Technology Data Exchange (ETDEWEB)

    SMEDLEY,J.; BEN-ZVI, I.; BOHON, J.; CHANG, X.; GROVER, R.; ISAKOVIC, A.; RAO, T.; WU, Q.

    2007-11-26

    High-average-current linear electron accelerators require photoinjectors capable of delivering tens to hundreds of mA average current, with peak currents of hundreds of amps. Standard photocathodes face significant challenges in meeting these requirements, and often have short operational lifetimes in an accelerator environment. We report on recent progress toward development of secondary emission amplifiers for photocathodes, which are intended to increase the achievable average current while protecting the cathode from the accelerator. The amplifier is a thin diamond wafer which converts energetic (few keV) primary electrons into hundreds of electron-hole pairs via secondary electron emission. The electrons drift through the diamond under an external bias and are emitted into vacuum via a hydrogen-terminated surface with negative electron affinity (NEA). Secondary emission gain of over 200 has been achieved. Two methods of patterning diamond, laser ablation and reactive-ion etching (RIE), are being developed to produce the required geometry. A variety of diagnostic techniques, including FTIR, SEM and AFM, have been used to characterize the diamonds.

  12. Nanoscale electromechanical parametric amplifier

    Energy Technology Data Exchange (ETDEWEB)

    Aleman, Benjamin Jose; Zettl, Alexander

    2016-09-20

    This disclosure provides systems, methods, and apparatus related to a parametric amplifier. In one aspect, a device includes an electron source electrode, a counter electrode, and a pumping electrode. The electron source electrode may include a conductive base and a flexible conductor. The flexible conductor may have a first end and a second end, with the second end of the flexible conductor being coupled to the conductive base. A cross-sectional dimension of the flexible conductor may be less than about 100 nanometers. The counter electrode may be disposed proximate the first end of the flexible conductor and spaced a first distance from the first end of the flexible conductor. The pumping electrode may be disposed proximate a length of the flexible conductor and spaced a second distance from the flexible conductor.

  13. Modeling of semiconductor optical amplifiers

    DEFF Research Database (Denmark)

    Mørk, Jesper; Bischoff, Svend; Berg, Tommy Winther;

    We discuss the modelling of semiconductor optical amplifiers with emphasis on their high-speed properties. Applications in linear amplification as well as ultrafast optical signal processing are reviewed. Finally, the possible role of quantum-dot based optical amplifiers is discussed.......We discuss the modelling of semiconductor optical amplifiers with emphasis on their high-speed properties. Applications in linear amplification as well as ultrafast optical signal processing are reviewed. Finally, the possible role of quantum-dot based optical amplifiers is discussed....

  14. Broadband amplified spontaneous emission from Er3+-doped single-mode tellurite fibre

    Institute of Scientific and Technical Information of China (English)

    Chen Dong-Dan; Zhang Qin-Yuan; Liu Yue-Hui; Xu Shan-Hui; Yang Zhong-Min; Deng Zai-De; Jiang Zhong-Hong

    2006-01-01

    This paper reports on the fabrication and characterization of a newly erbium-doped single-mode tellurite glass-fibre applicable for 1.5-μm optical amplifiers. A very broad erbium amplified spontaneous emission in the range 1450-1650 nm from erbium-doped single-mode tclluritc glass-fibre is obtained upon excitation of a 980-nm laser diode. The effects of the length of glass-fibre and the pumping power of laser diode on the amplified spontaneous emission are discussed.The result indicates that the tellurite glass-fibre is a promising candidate for designing fibre-optic amplifiers and lasers.

  15. International Standardization Activities for Optical Amplifiers

    Institute of Scientific and Technical Information of China (English)

    Haruo Okamura

    2003-01-01

    International standardization activities for Optical Amplifiers at IECTC86 and ITU-T SG15 are reviewed. Current discussions include Optical Amplifier safety guideline, Reliability standard, Rest methods of Noise and PMD, Definitions of Raman amplifier parameters and OA classification.

  16. The downstream industry compared to market

    International Nuclear Information System (INIS)

    J.L. Schilansky introduces here the difficult question of the downstream industry compared to market in recalling the recent structural changes (behaviour of customers, behaviour of the USA- and China-governments), the increase of the European and French regulations, the climatic change and the conjectural impact of the crisis on the refining industry. (O.M.)

  17. New Packaging for Amplifier Slabs

    Energy Technology Data Exchange (ETDEWEB)

    Riley, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Thorsness, C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Suratwala, T. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Steele, R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Rogowski, G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-03-18

    The following memo provides a discussion and detailed procedure for a new finished amplifier slab shipping and storage container. The new package is designed to maintain an environment of <5% RH to minimize weathering.

  18. TARC: Carlo Rubbia's Energy Amplifier

    CERN Multimedia

    Laurent Guiraud

    1997-01-01

    Transmutation by Adiabatic Resonance Crossing (TARC) is Carlo Rubbia's energy amplifier. This CERN experiment demonstrated that long-lived fission fragments, such as 99-TC, can be efficiently destroyed.

  19. A Transformer Class E Amplifier

    Directory of Open Access Journals (Sweden)

    Mikolajewski Miroslaw

    2014-12-01

    Full Text Available In a high-efficiency Class E ZVS resonant amplifier a matching and isolation transformer can replace some or even all inductive components of the amplifier thus simplifying the circuit and reducing its cost. In the paper a theoretical analysis, a design example and its experimental verification for a transformer Class E amplifier are presented. In the experimental amplifier with a transformer as the only inductive component in the circuit high efficiency ηMAX = 0.95 was achieved for supply voltage VI = 36 V, maximum output power POMAX = 100 W and the switching frequency f = 300 kHz. Measured parameters and waveforms showed a good agreement with theoretical predictions. Moreover, the relative bandwidth of the switching frequency was only 19% to obtain output power control from 4.8 W to POMAX with efficiency not less than 0.9 in the regulation range.

  20. A KIND OF NEW AMPLIFIER

    Institute of Scientific and Technical Information of China (English)

    YIN XUN-HE; FENG RU-PENG; REN YONG

    2000-01-01

    Chaotic characteristics in the iteration of logistic map (one-dimensional discrete dynamic system) are simulatedand analyzed. The circuit implementation of a kind of chaotic amplifier model is based on the chaotic characteristicsthat chaos is sensitively dependent on its initial conditions, and the circuit simulation result is given using simulationprogram with integrated circuit emphasis for personal computer (PSPICE), and is compared with linear amplifier.Advantages and disadvantages of such a model are indicated.

  1. MITIGATION OF SEDIMENTATION HAZARDS DOWNSTREAM FROM RESERVOIRS

    Institute of Scientific and Technical Information of China (English)

    Ellen WOHL; Sara RATHBURN

    2003-01-01

    Many reservoirs currently in operation trap most or all of the sediment entering the reservoir,creating sediment-depleted conditions downstream. This may cause channel adjustment in the form of bank erosion, bed erosion, substrate coarsening, and channel planform change. Channel adjustment may also result from episodic sediment releases during reservoir operation, or from sediment evacuation following dam removal. Channel adjustment to increased sediment influx depends on the magnitude, frequency, duration and grain-size distribution of the sediment releases, and on the downstream channel characteristics. Channel adjustment may occur as a change in substrate sizedistribution, filling of pools, general bed aggradation, lateral instability, change in channel planform,and/or floodplain aggradation. The increased sediment availability may alter aquatic and riparian habitat, reduce water quality, distribute adsorbed contaminants along the river corridor, and provide germination sites for exotic vegetation. Mitigation of these sedimentation hazards requires: (1)mapping grain-size distribution within the reservoir and estimating the grain-size distributions of sediment that will be mobilized through time; (2) mapping shear stress and sediment transport capacity as a function of discharge on the basis of channel units for the length of the river likely to be affected; (3) mapping potential depositional zones, and aquatic habitat and "acceptable losses," along the downstream channel, and comparing these volumes to the total sediment volume stored in the reservoir as a means of estimating total transport capacity required to mobilize reservoir sediment delivered to the channel; (4) designing discharge and sediment release regime (magnitude, frequency,duration) to minimize adverse downstream impacts; and (5) developing plans to remove, treat, contain,or track contaminants, and to restrict establishment of exotic vegetation. The North Fork Poudre River in Colorado is used to

  2. Upstream versus Downstream Implementation of Climate Policy

    OpenAIRE

    Erin T. Mansur

    2010-01-01

    This chapter examines the tradeoffs of regulating upstream (e.g., coal, natural gas, and refined petroleum product producers) versus regulating downstream (e.g., direct sources of greenhouse gases (GHG)). In general, regulating at the source provides polluters with incentives to choose among more opportunities to abate pollution. This chapter develops a simple theoretical model that shows why this added flexibility achieves the lowest overall costs. I broaden the theory to incorporate several...

  3. Mechanical downstream processing of Single Cell Oils

    OpenAIRE

    De Coninck, Maarten; Van Hecke, Renaat; Deprez, Koen; De Baerdemaeker, Josse

    2011-01-01

    During the last years, the third generation of bio fuels has been arousing more and more interest. Under certain conditions some micro organisms: yeasts, algae, fungi and bacteria, can accumulate up to 50% oil (based on dry weight). These so-called ‘Single cell oils’ (SCO) are well known in this context. Nowadays, harvesting and recovery of interesting products from microalgae is one of the most problematic areas of algal biofuel production technology. The traditional downstream process,...

  4. India's Downstream Petroleum Sector

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This study provides a holistic examination of pricing and investment dynamics in India's downstream petroleum sector. It analyses the current pricing practices, highlights the tremendous fiscal cost of current pricing and regulatory arrangements, and examines the sectoral investment dynamics. It also looks at potential paths towards market-based reform along which the Indian government may move, while at the same time protecting energy market access for India's large poor population.

  5. Downstream mode of competition with upstream market power

    OpenAIRE

    Manasakis, Constantine; Vlassis, Minas

    2013-01-01

    In a two-tier oligopoly, where the downstream firms are locked in pair-wise exclusive relationships with their upstream input suppliers, the equilibrium mode of competition in the downstream market is endogenously determined as a renegotiation-proof contract signed between each downstream firm and its exclusive upstream input supplier. We find that the upstream-downstream exclusive relationships credibly sustain the Cournot (Bertrand) mode of competition in the downstream market, when the goo...

  6. Vertical Integration and Market Foreclosure with Convex Downstream Costs

    OpenAIRE

    Baake, Pio; Kamecke, Ulrich; Normann, Hans-Theo

    2001-01-01

    In a framework with an upstream monopoly and a downstream duopoly, we analyze the impact of convex costs on the downstream level. In contrast to the case of constant marginal costs, vertical integration does not imply complete market foreclosure. While the non-integrated downstream firm receives a strictly positive amount of the intermediate good, the downstream allocation is inefficient. However, a parametrized example indicates that competition at the downstream level may increase aggregate...

  7. EMI-resilient amplifier circuits

    CERN Document Server

    van der Horst, Marcel J; Linnenbank, André C

    2014-01-01

    This book enables circuit designers to reduce the errors introduced by the fundamental limitations and electromagnetic interference (EMI) in negative-feedback amplifiers.  The authors describe a systematic design approach for application specific negative-feedback amplifiers, with specified signal-to-error ratio (SER).  This approach enables designers to calculate noise, bandwidth, EMI, and the required bias parameters of the transistors used in  application specific amplifiers in order to meet the SER requirements.   ·         Describes design methods that incorporate electromagnetic interference (EMI) in the design of application specific negative-feedback amplifiers; ·         Provides designers with a structured methodology to avoid the use of trial and error in meeting signal-to-error ratio (SER) requirements; ·         Equips designers to increase EMI immunity of the amplifier itself, thus avoiding filtering at the input, reducing the number of components and avoiding detr...

  8. Low-Noise Band-Pass Amplifier

    Science.gov (United States)

    Kleinberg, L.

    1982-01-01

    Circuit uses standard components to overcome common limitation of JFET amplifiers. Low-noise band-pass amplifier employs JFET and operational amplifier. High gain and band-pass characteristics are achieved with suitable choice of resistances and capacitances. Circuit should find use as low-noise amplifier, for example as first stage instrumentation systems.

  9. Gaussian amplifier for nuclear spectrometry

    International Nuclear Information System (INIS)

    One of the major goals of nuclear spectrometry is the determination of the energy spectrum of a radioactive source. To measure this spectrum with electronic instrumentation one need to use a nuclear spectrometry chain of which the amplifier is part of, and whose filter shaping considerably influences the final energy resolution achieved. The amplifier released accomplishes a 7th order Gaussian filter shape with Taylor series approximation synthesized by the Shifted Companion Form and mounted using only electronic components availablein Brazil. The final version has been tested and the results showed a very good performance and the energy resolution achieved was equivalent to the imported models. (Author)

  10. Teaching "Candide": A Debate.

    Science.gov (United States)

    Braun, Theodore E. D.; And Others

    1988-01-01

    Two different approaches to teaching Voltaire's "Candide", one deriving meaning from the textual fabric or "inside" of the story and the other focusing on the author's "external" intent in writing the story, are presented and compared. (MSE)

  11. Dielectric waveguide amplifiers and lasers

    NARCIS (Netherlands)

    Pollnau, M.

    2014-01-01

    The performance of semiconductor amplifiers and lasers has made them the preferred choice for optical gain on a micro-chip. In the past few years, we have demonstrated that also rare-earth-ion-doped dielectric waveguides show remarkable performance, ranging from a small-signal gain per unit length o

  12. Thermal recovery of NIF amplifiers

    Energy Technology Data Exchange (ETDEWEB)

    Sutton, S.; Marshall, C.; Petty, C.; Smith, L.; van Wonterghem, B.; Mills, S.

    1997-02-01

    The issue of thermal recovery of the NIF amplifiers has taken on increased emphasis as program goals move toward increasing the shot rate to once every four hours. This paper addresses the technical issues associated with achieving thermal recovery in the NIF amplifiers. We identify two temperature related thermal recovery quantities: (1) the difference between the average slab temperature and the temperature of other surfaces in the amplifier cavity, and (2) the temperature difference in the slab over the aperture. The first quantity relates to optical disturbances in the gas column in the system, while the second quantity is associated with optical aberrations in the laser media itself. Calculations and experiments are used to quantify recovery criteria, and develop cooling approaches. The cooling approaches discussed are (1) active cooling of the flashlamps with ambient gas and chilled gas, and (2) active cooling of the slab edge cladding. Calculations indicate that the NIF baseline cooling approach of 20 cfm per lamp ambient temperature gas flow in both the central and side flashlamp cassettes is capable of meeting thermal recovery requirements for an 8 hour shot period, while to achieve a 4 hour shot period requires use of chilled gas and edge cladding cooling. In addition, the effect of changing the amplifier cavity and beamtube fill gas from nitrogen to helium is addressed, showing that a factor of 8 reduction in the sensitivity to thermal disturbances is possible. 6 refs., 9 figs., 1 tab.

  13. A wideband dc-coupled amplifier

    International Nuclear Information System (INIS)

    A method is described whereby an ac-coupled high-frequency amplifier and a dc-coupled low-frequency amplifier are connected in parallel in order to obtain a dc-coupled wideband amplifier. By using an operational amplifier which compares the output voltage with the input voltage, the low-frequency amplifier contributes to the overall gain only when the gain of the ac-coupled amplifier droops at low frequencies. Thus, no frequency splitting networks are necessary and the excellent low-frequency features of an operational amplifier are added to those of the ac-coupled wideband amplifier. As an example, a low noise amplifier is described which exhibits a hundredfold gain, a bandwidth from dc to 550 MHz, an input bias current of less than 1 nA, and an output voltage range of ±1 V

  14. Prototype Small Footprint Amplifier for Piezoelectric Deformable Mirrors

    Science.gov (United States)

    Caputa, Kris; Herriot, Glen; Niebergal, Joel; Zielinski, Adam

    2011-09-01

    AO subsystems of the ELT observatories will incorporate deformable mirrors with an order of magnitude larger number of piezoelectric actuators than the AO systems currently deployed. Simply scaling up the drive electronics that are presently available commercially would substantially drive up the AO cost, pose unacceptably high demands for the supply power and heat dissipation, and occupy large physical volume. We have set out to prototype a high voltage amplifier that is compact enough to allow packaging 100 amplifier channels on a single 6U Eurocard with the goal to have a DM drive channel density of 1200 per 6U VME crate. Individual amplifier circuits should be driven by a multichannel A/D converter, consume no more than 0.5W from the +/-400V power supply, be slew rate limited in hardware, and be short-circuit protected. The component cost should be an order of magnitude less than the integrated circuit high voltage amplifiers currently on the market. We started out with modeling candidate circuits in SPICE, then built physical prototypes using inexpensive off the shelf components. In this paper we present experimental results of exposing several prototype circuits to both normal operating conditions and foreseeable fault conditions. The performance is evaluated against the AO requirements for the output range and bandwidth and the DM actuator safety requirements.

  15. Plasma waves downstream of weak collisionless shocks

    Science.gov (United States)

    Coroniti, F. V.; Greenstadt, E. W.; Moses, S. L.; Smith, E. J.; Tsurutani, B. T.

    1993-01-01

    In September 1983 the International Sun Earth Explorer 3 (ISEE 3) International Cometary Explorer (ICE) spacecraft made a long traversal of the distant dawnside flank region of the Earth's magnetosphere and had many encounters with the low Mach number bow shock. These weak shocks excite plasma wave electric field turbulence with amplitudes comparable to those detected in the much stronger bow shock near the nose region. Downstream of quasi-perpendicular (quasi-parallel) shocks, the E field spectra exhibit a strong peak (plateau) at midfrequencies (1 - 3 kHz); the plateau shape is produced by a low-frequency (100 - 300 Hz) emission which is more intense behind downstream of two quasi-perpendicular shocks show that the low frequency signals are polarized parallel to the magnetic field, whereas the midfrequency emissions are unpolarized or only weakly polarized. A new high frequency (10 - 30 kHz) emission which is above the maximum Doppler shift exhibit a distinct peak at high frequencies; this peak is often blurred by the large amplitude fluctuations of the midfrequency waves. The high-frequency component is strongly polarized along the magnetic field and varies independently of the lower-frequency waves.

  16. Genome profiling of ERBB2-amplified breast cancers

    International Nuclear Information System (INIS)

    Around 20% of breast cancers (BC) show ERBB2 gene amplification and overexpression of the ERBB2 tyrosine kinase receptor. They are associated with a poor prognosis but can benefit from targeted therapy. A better knowledge of these BCs, genomically and biologically heterogeneous, may help understand their behavior and design new therapeutic strategies. We defined the high resolution genome and gene expression profiles of 54 ERBB2-amplified BCs using 244K oligonucleotide array-comparative genomic hybridization and whole-genome DNA microarrays. Expression of ERBB2, phosphorylated ERBB2, EGFR, IGF1R and FOXA1 proteins was assessed by immunohistochemistry to evaluate the functional ERBB2 status and identify co-expressions. First, we identified the ERBB2-C17orf37-GRB7 genomic segment as the minimal common 17q12-q21 amplicon, and CRKRS and IKZF3 as the most frequent centromeric and telomeric amplicon borders, respectively. Second, GISTIC analysis identified 17 other genome regions affected by copy number aberration (CNA) (amplifications, gains, losses). The expression of 37 genes of these regions was deregulated. Third, two types of heterogeneity were observed in ERBB2-amplified BCs. The genomic profiles of estrogen receptor-postive (ER+) and negative (ER-) ERBB2-amplified BCs were different. The WNT/β-catenin signaling pathway was involved in ER- ERBB2-amplified BCs, and PVT1 and TRPS1 were candidate oncogenes associated with ER+ ERBB2-amplified BCs. The size of the ERBB2 amplicon was different in inflammatory (IBC) and non-inflammatory BCs. ERBB2-amplified IBCs were characterized by the downregulated and upregulated mRNA expression of ten and two genes in proportion to CNA, respectively. IHC results showed (i) a linear relationship between ERBB2 gene amplification and its gene and protein expressions with a good correlation between ERBB2 expression and phosphorylation status; (ii) a potential signaling cross-talk between EGFR or IGF1R and ERBB2, which could influence

  17. 40 CFR 80.69 - Requirements for downstream oxygenate blending.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Requirements for downstream oxygenate... downstream oxygenate blending. The requirements of this section apply to all reformulated gasoline blendstock... annual compliance period; (D) A process for notifying oxygenate blenders and other downstream parties...

  18. Single conversion stage amplifier - SICAM

    Energy Technology Data Exchange (ETDEWEB)

    Ljusev, P.

    2005-12-15

    This Ph.D. thesis presents a thorough analysis of the so called SICAM - SIngle Converter stage AMplifier approach to building direct energy conversion audio power amplifiers. The mainstream approach for building isolated audio power amplifiers today consists of isolated DC power supply and Class D amplifier, which essentially represents a two stage solution, where each of the components can be viewed as separate and independent part. The proposed SICAM solution strives for direct energy conversion from the mains to the audio output, by dedicating the operation of the components one to another and integrating their functions, so that the final audio power amplifier represents a single-stage topology with higher efficiency, lower volume, less board space, lower component count and subsequently lower cost. The SICAM approach is both applicable to non-isolated and isolated audio power amplifiers, but the problems encountered in these two cases are different. Non-isolated SICAM solutions are intended for both AC mains-connected and battery-powered devices. In non-isolated mains-connected SICAMs the main idea is to simplify the power supply or even provide integrated power factor correction (PFC) functions, while still maintaining low component stress and good audio performance by generally decreasing the input voltage level to the Class D audio power amplifier. On the other hand, non-isolated battery-powered SICAMs have to cope with the ever changing battery voltage and provide output voltage levels which are both lower and higher than the battery voltage, while still being simple and single-stage energy conversion solutions. In isolated SICAMs the isolation transformer adjusts the voltage level on the secondary side to the desired level, so the main challenges here are decreasing the size of the magnetic core and reducing the number and size of bulky reactive components as much as possible. The main focus of this thesis is directed towards the isolated SICAMs and

  19. Channel changes downstream from a dam

    Science.gov (United States)

    Hadley, R.F.; Emmett, W.W.

    1998-01-01

    A flood-control dam was completed during 1979 on Bear Creek, a small tributary stream to the South Platte River in the Denver, Colorado, area. Before and after dam closure, repetitive surveys between 1977 and 1992 at five cross sections downstream of the dam documented changes in channel morphology. During this 15-year period, channel width increased slightly, but channel depth increased by more than 40 percent. Within the study reach, stream gradient decreased and median bed material sizes coarsened from sand in the pools and fine gravel on the riffle to a median coarse gravel throughout the reach. The most striking visual change was from a sparse growth of streamside grasses to a dense growth of riparian woody vegetation.

  20. Experimental Study on Scours Downstream of Floodgates

    Institute of Scientific and Technical Information of China (English)

    张玮; 陈锡林; 徐金环; 李国臣; 王志谦

    2000-01-01

    The river reach downstream of a floodgate at the estuary of the Xinyihe River is about 1.3km long, and the riverbed is composed of clotty clay. In the experiment, soil samples are taken from the construction site, and the incipient velocity is determined in a laboratory flume, and it is used to design the scour model and to select model sand material. The experimental results show that scours below the floodgate is unavoidable due to large discharge and low tidal level. Scours is caused by two factors: the rapid flow passing though the floodgate and the water drop near the river mouth during low tide, and the scour below the floodgate is more critical to the structural design. It is suggested that anti-scour walls should be used instead of riprap. The ideas and methods adopted in the experiment can be used as reference in the study on river scour under similar conditions.

  1. Downstream process options for the ABE fermentation.

    Science.gov (United States)

    Friedl, Anton

    2016-05-01

    Butanol is a very interesting substance both for the chemical industry and as a biofuel. The classical distillation process for the removal of butanol is far too energy demanding, at a factor of 220% of the energy content of butanol. Alternative separation processes studied are hybrid processes of gas-stripping, liquid-liquid extraction and pervaporation with distillation and a novel adsorption/drying/desorption hybrid process. Compared with the energy content of butanol, the resulting energy demand for butanol separation and concentration of optimized hybrid processes is 11%-22% for pervaporation/distillation and 11%-17% for liquid-liquid extraction/distillation. For a novel adsorption/drying/desorption process, the energy demand is 9.4%. But all downstream process options need further proof of industrial applicability. PMID:27020411

  2. Modeling of channel erosion downstream spillway dams

    Directory of Open Access Journals (Sweden)

    M.A. Mikhalev

    2013-03-01

    Full Text Available The channel erosion downstream spillway dams in non-cohesive materials has been analyzed from the viewpoint of methods of similarity and dimension theory. The obtained criterion equation connects the maximum depth of the local erosion with its determining parameters: length of concrete lining of bed in the down water of the spillway dam; Froude number at the contracted cross section; Archimedes and Reynolds criterions; submergence factor of hydraulic jump. The problem may be formulated as follows: the geometric size of the structure, kinematics and dynamics of the flows in the model are similar to that in the prototype. Conditions under which the characteristic depth of the local erosion in the model would be recomputed into the prototype, like any geometric size, are being discussed.

  3. The jet membrane-experiment: downstream sampling

    International Nuclear Information System (INIS)

    The invasion separation effect of the free jet structure was found in 1966 at Saclay. In the Downstream Sampling Configuration patended by Campargue (1967), the light fraction is withdrawn from the supersonic central core, by skimming the separating free jet. From experimental and theoretical results obtained for gas and isotopic mixtures, the following points linked to operation and equipment costs, are considered: system description; influence of mass ratio, expansion ratio, nature of separating gas, ratio of upflow to separating jet flow, rarefaction. Fron an uninteresting aspect of Jet Membrane (elimination of background penetration), a new principle has been discovered to produce nozzle beams which may be of great interest for other separation processes involving free jets and/or molecular beams

  4. Ammonia downstream from HH 80 North

    Science.gov (United States)

    Girart, Jose M.; Rodriguez, Luis F.; Anglada, Guillem; Estalella, Robert; Torrelles, Jose, M.; Marti, Josep; Pena, Miriam; Ayala, Sandra; Curiel, Salvador; Noriega-Crespo, Alberto

    1994-01-01

    HH 80-81 are two optically visible Herbig-Haro (HH) objects located about 5 minutes south of their exciting source IRAS 18162-2048. Displaced symmetrically to the north of this luminous IRAS source, a possible HH counterpart was recently detected as a radio continuum source with the very large array (VLA). This radio source, HH 80 North, has been proposed to be a member of the Herbig-Haro class since its centimeter flux density, angular size, spectral index, and morphology are all similar to those of HH 80. However, no object has been detected at optical wavelengths at the position of HH 80 North, possibly because of high extinction, and the confirmation of the radio continuum source as an HH object has not been possible. In the prototypical Herbig-Haro objects HH 1 and 2, ammonia emission has been detected downstream of the flow in both objects. This detection has been intepreted as a result of an enhancement in the ammonia emission produced by the radiation field of the shock associated with the HH object. In this Letter we report the detection of the (1,1) and (2,2) inversion transitions of ammonia downstream HH 80 North. This detection gives strong suppport to the interpretation of HH 80 North as a heavily obscured HH object. In addition, we suggest that ammonia emission may be a tracer of embedded Herbig-Haro objects in other regions of star formation. A 60 micrometer IRAS source could be associated with HH 80 North and with the ammonia condensation. A tentative explanation for the far-infrared emission as arising in dust heated by their optical and UV radiation of the HH object is presented.

  5. Higher order mode optical fiber Raman amplifiers

    DEFF Research Database (Denmark)

    Rottwitt, Karsten; Friis, Søren Michael Mørk; Usuga Castaneda, Mario A.;

    2016-01-01

    We review higher order mode Raman amplifiers and discuss recent theoretical as well as experimental results including system demonstrations.......We review higher order mode Raman amplifiers and discuss recent theoretical as well as experimental results including system demonstrations....

  6. Analog circuit design designing high performance amplifiers

    CERN Document Server

    Feucht, Dennis

    2010-01-01

    The third volume Designing High Performance Amplifiers applies the concepts from the first two volumes. It is an advanced treatment of amplifier design/analysis emphasizing both wideband and precision amplification.

  7. Challenges in higher order mode Raman amplifiers

    DEFF Research Database (Denmark)

    Rottwitt, Karsten; Nielsen, Kristian; Friis, Søren Michael Mørk;

    2015-01-01

    A higher order Raman amplifier model that take random mode coupling into account ispresented. Mode dependent gain and signal power fluctuations at the output of the higher order modeRaman amplifier are discussed...

  8. Quantum Theory of Laser Amplifiers.

    Science.gov (United States)

    Mander, Gillian Linda

    Available from UMI in association with The British Library. Requires signed TDF. We calculate the input-output characteristics of a below threshold laser amplifier. Expressions are derived for the output second- and fourth-order spectral and temporal correlation functions in terms of the corresponding input quantities, and for the photocount first and second factorial moments for both homodyne and direct detection. The general results are applied to several cases of practical interest, including specific non-classical input states. We show that a maximum of twofold amplification is permitted if squeezing in the input is to survive at the output. Similarly, for preservation of photon antibunching in amplification we show that only very small gains are allowed. The model treated here provides a detailed example of the amplifier noise limitations imposed by quantum mechanics. In particular, we show that minimum noise occurs in a cavity that is asymmetric with respect to the mirror reflectivities. The latter part of this work treats the above threshold laser amplifier. The laser output is back-scattered from a moving target to provide a weak Doppler-shifted signal which re-enters the laser cavity and is amplified. We show that the three-level atomic lasing medium is equivalent to a two-level medium pumped by an inverted bath. We use the methods of quantum statistical analysis to obtain time -evolution equations for the c-number amplitudes of the laser and signal fields. We show that the results may be applied to the below threshold regime for appropriate values of the pump parameter. By considering the amplitude differential gain we show explicitly that the behaviour of the laser around threshold is characteristic of a second -order phase transition. We calculate the output intensity gain appropriate to a heterodyne detection process, and find good agreement between the predicted gain profiles and measured data for both carbon dioxide and argon-ion lasers.

  9. 338-GHz Semiconductor Amplifier Module

    Science.gov (United States)

    Samoska, Lorene A.; Gaier, Todd C.; Soria, Mary M.; Fung, King Man; Rasisic, Vesna; Deal, William; Leong, Kevin; Mei, Xiao Bing; Yoshida, Wayne; Liu, Po-Hsin; Uyeda, Jansen; Lai, Richard

    2010-01-01

    Research findings were reported from an investigation of new gallium nitride (GaN) monolithic millimeter-wave integrated circuit (MMIC) power amplifiers (PAs) targeting the highest output power and the highest efficiency for class-A operation in W-band (75-110 GHz). W-band PAs are a major component of many frequency multiplied submillimeter-wave LO signal sources. For spectrometer arrays, substantial W-band power is required due to the passive lossy frequency multipliers.

  10. High power regenerative laser amplifier

    Science.gov (United States)

    Miller, J.L.; Hackel, L.A.; Dane, C.B.; Zapata, L.E.

    1994-02-08

    A regenerative amplifier design capable of operating at high energy per pulse, for instance, from 20-100 Joules, at moderate repetition rates, for instance from 5-20 Hertz is provided. The laser amplifier comprises a gain medium and source of pump energy coupled with the gain medium; a Pockels cell, which rotates an incident beam in response to application of a control signal; an optical relay system defining a first relay plane near the gain medium and a second relay plane near the rotator; and a plurality of reflectors configured to define an optical path through the gain medium, optical relay and Pockels cell, such that each transit of the optical path includes at least one pass through the gain medium and only one pass through the Pockels cell. An input coupler, and an output coupler are provided, implemented by a single polarizer. A control circuit coupled to the Pockels cell generates the control signal in timed relationship with the input pulse so that the input pulse is captured by the input coupler and proceeds through at least one transit of the optical path, and then the control signal is applied to cause rotation of the pulse to a polarization reflected by the polarizer, after which the captured pulse passes through the gain medium at least once more and is reflected out of the optical path by the polarizer before passing through the rotator again to provide an amplified pulse. 7 figures.

  11. SPS RF System Amplifier plant

    CERN Multimedia

    1977-01-01

    The picture shows a 2 MW, 200 MHz amplifier plant with feeder lines. The main RF-system of the SPS comprises four cavities: two of 20 m length and two of 16.5 m length. They are all installed in one long straight section (LSS 3). These cavities are of the travelling-wave type operating at a centre frequency of 200.2 MHz. They are wideband, filling time about 700 ns and untuned. The power amplifiers, using tetrodes are installed in a surface building 200 m from the cavities. Initially only two cavities were installed, a third cavity was installed in 1978 and a forth one in 1979. The number of power amplifiers was also increased: to the first 2 MW plant a second 2 MW plant was added and by end 1979 there were 8 500 kW units combined in pairs to feed each of the 4 cavities with up to about 1 MW RF power, resulting in a total accelerating voltage of about 8 MV. See also 7412016X, 7412017X, 7411048X.

  12. Improved charge amplifier using hybrid hysteresis compensation

    Science.gov (United States)

    Amin-Shahidi, Darya; Trumper, David L.

    2013-08-01

    We present a novel charge amplifier, with a robust feedback circuit and a method for compensating piezoelectric actuator's hysteresis at low frequencies. The amplifier uses a modified feedback circuit which improves robustness to the addition of series load impedance such as in cabling. We also describe a hybrid hysteresis compensation method for enabling the charge amplifier to reduce hysteresis at low frequencies. Experimental results demonstrate the utility of the new amplifier design.

  13. Spontaneous emission from saturated parametric amplifiers

    DEFF Research Database (Denmark)

    Rottwitt, Karsten; Ott, Johan Raunkjær; Steffensen, Henrik;

    2009-01-01

    Noise performance of parametric amplifiers is typically calculated assuming un-depleted operation. However, in many applications especially when applied as regenerative amplifiers in systems based on phase shift keyed modulation schemes, this assumption is not valid. Here we show the impact on ac...... on accumulated spontaneous emission for a parametric amplifier operated in saturation....

  14. European Research on THz Vacuum Amplifiers

    DEFF Research Database (Denmark)

    Brunetti, F.; Cojocarua, C.-S.; de Rossi, A.;

    2010-01-01

    The OPTHER (OPtically Driven TeraHertz AmplifiERs) project represents a considerable advancement in the field of high frequency amplification. The design and realization of a THz amplifier within this project is a consolidation of efforts at the international level from the main players of the Eu...

  15. A High-performance Small Signal Amplifier

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    According to questions in the design of high quality small signal amplifier, this paper gave a new-type high performance small signal amplifier. The paper selected the operational amplifier of ICL Company and designed a new-type circuit with simple, low cost and excellent performance.

  16. Radio frequency amplifier with effective decoupling

    NARCIS (Netherlands)

    Besling, W.F.A.; Bakker, T.W.; Lamy, Y.; Kochupurackal, J.; Roozeboom, F.

    2011-01-01

    A variety of circuits, methods and devices are implemented for radiofrequency amplifiers. According to one such implementation, a radiofrequency amplifier circuit is implemented in a SMD package. The circuit amplifies a radiofrequency signal having a base-band portion and a plurality of carrier sign

  17. low pump power photonic crystal fibre amplifiers

    DEFF Research Database (Denmark)

    Hougaard, Kristian G.; Broeng, Jes; Bjarklev, Anders Overgaard

    2003-01-01

    Designs of low pump power optical amplifiers, based on photonic crystal fibres are presented. The potential of these fibre amplifiers is investigated, and it is demonstrated that such amplifiers may deliver gains of more than 15 dB at 1550 nm with less than 1 mW of optical pump power....

  18. Primary and Presidential Candidates

    DEFF Research Database (Denmark)

    Goddard, Joseph

    2012-01-01

    This article looks at primary and presidential candidates in 2008 and 2012. Evidence suggests that voters are less influenced by candidates’ color, gender, or religious observation than previously. Conversely, markers of difference remain salient in the imaginations of pollsters and journalists...

  19. Log amplifier with pole-zero compensation

    Science.gov (United States)

    Brookshier, William

    1987-01-01

    A logarithmic amplifier circuit provides pole-zero compensation for improved stability and response time over 6-8 decades of input signal frequency. The amplifier circuit includes a first operational amplifier with a first feedback loop which includes a second, inverting operational amplifier in a second feedback loop. The compensated output signal is provided by the second operational amplifier with the log elements, i.e., resistors, and the compensating capacitors in each of the feedback loops having equal values so that each break point or pole is offset by a compensating break point or zero.

  20. Semiconductor quantum-dot lasers and amplifiers

    DEFF Research Database (Denmark)

    Hvam, Jørn Märcher; Borri, Paola; Ledentsov, N. N.;

    2002-01-01

    -power surface emitting VCSELs. We investigated the ultrafast dynamics of quantum-dot semiconductor optical amplifiers. The dephasing time at room temperature of the ground-state transition in semiconductor quantum dots is around 250 fs in an unbiased amplifier, decreasing to below 50 fs when the amplifier...... is biased to positive net gain. We have further measured gain recovery times in quantum dot amplifiers that are significantly lower than in bulk and quantum-well semiconductor optical amplifiers. This is promising for future demonstration of quantum dot devices with high modulation bandwidth...

  1. HIGH AVERAGE POWER OPTICAL FEL AMPLIFIERS

    International Nuclear Information System (INIS)

    Historically, the first demonstration of the optical FEL was in an amplifier configuration at Stanford University [l]. There were other notable instances of amplifying a seed laser, such as the LLNL PALADIN amplifier [2] and the BNL ATF High-Gain Harmonic Generation FEL [3]. However, for the most part FELs are operated as oscillators or self amplified spontaneous emission devices. Yet, in wavelength regimes where a conventional laser seed can be used, the FEL can be used as an amplifier. One promising application is for very high average power generation, for instance FEL's with average power of 100 kW or more. The high electron beam power, high brightness and high efficiency that can be achieved with photoinjectors and superconducting Energy Recovery Linacs (ERL) combine well with the high-gain FEL amplifier to produce unprecedented average power FELs. This combination has a number of advantages. In particular, we show that for a given FEL power, an FEL amplifier can introduce lower energy spread in the beam as compared to a traditional oscillator. This properly gives the ERL based FEL amplifier a great wall-plug to optical power efficiency advantage. The optics for an amplifier is simple and compact. In addition to the general features of the high average power FEL amplifier, we will look at a 100 kW class FEL amplifier is being designed to operate on the 0.5 ampere Energy Recovery Linac which is under construction at Brookhaven National Laboratory's Collider-Accelerator Department

  2. High temperature charge amplifier for geothermal applications

    Science.gov (United States)

    Lindblom, Scott C.; Maldonado, Frank J.; Henfling, Joseph A.

    2015-12-08

    An amplifier circuit in a multi-chip module includes a charge to voltage converter circuit, a voltage amplifier a low pass filter and a voltage to current converter. The charge to voltage converter receives a signal representing an electrical charge and generates a voltage signal proportional to the input signal. The voltage amplifier receives the voltage signal from the charge to voltage converter, then amplifies the voltage signal by the gain factor to output an amplified voltage signal. The lowpass filter passes low frequency components of the amplified voltage signal and attenuates frequency components greater than a cutoff frequency. The voltage to current converter receives the output signal of the lowpass filter and converts the output signal to a current output signal; wherein an amplifier circuit output is selectable between the output signal of the lowpass filter and the current output signal.

  3. Microbial production of scleroglucan and downstream processing

    Directory of Open Access Journals (Sweden)

    Natalia Alejandra Castillo

    2015-10-01

    Full Text Available Synthetic petroleum-based polymers and natural plant polymers have the disadvantage of restricted sources, in addition to the non-biodegradability of the former ones. In contrast, eco-sustainable microbial polysaccharides, of low-cost and standardized production, represent an alternative to address this situation. With a strong global market, they attracted worldwide attention because of their novel and unique physico-chemical properties as well as varied industrial applications, and many of them are promptly becoming economically competitive. Scleroglucan, a beta-1,3-beta-1,6-glucan secreted by Sclerotium fungi, exhibits high potential for commercialization and may show different branching frequency, side-chain length and/or molecular weight depending on the producing strain or culture conditions. Water-solubility, viscosifying ability and wide stability over temperature, pH and salinity make scleroglucan useful for different biotechnological (enhanced oil recovery, food additives, drug delivery, cosmetic and pharmaceutical products, biocompatible materials, etc., and biomedical (immunoceutical, antitumor, etc. applications. It can be copiously produced at bioreactor scale under standardized conditions, where a high EPS concentration normally governs the process optimization. Operative and nutritional conditions, as well as the incidence of scleroglucan downstream processing will be discussed in this chapter. The relevance of using standardized inocula from selected strains and experiences concerning the intricate scleroglucan scaling-up will be also herein outlined.

  4. Microbial production of scleroglucan and downstream processing

    Science.gov (United States)

    Castillo, Natalia A.; Valdez, Alejandra L.; Fariña, Julia I.

    2015-01-01

    Synthetic petroleum-based polymers and natural plant polymers have the disadvantage of restricted sources, in addition to the non-biodegradability of the former ones. In contrast, eco-sustainable microbial polysaccharides, of low-cost and standardized production, represent an alternative to address this situation. With a strong global market, they attracted worldwide attention because of their novel and unique physico-chemical properties as well as varied industrial applications, and many of them are promptly becoming economically competitive. Scleroglucan, a β-1,3-β-1,6-glucan secreted by Sclerotium fungi, exhibits high potential for commercialization and may show different branching frequency, side-chain length, and/or molecular weight depending on the producing strain or culture conditions. Water-solubility, viscosifying ability and wide stability over temperature, pH and salinity make scleroglucan useful for different biotechnological (enhanced oil recovery, food additives, drug delivery, cosmetic and pharmaceutical products, biocompatible materials, etc.), and biomedical (immunoceutical, antitumor, etc.) applications. It can be copiously produced at bioreactor scale under standardized conditions, where a high exopolysaccharide concentration normally governs the process optimization. Operative and nutritional conditions, as well as the incidence of scleroglucan downstream processing will be discussed in this chapter. The relevance of using standardized inocula from selected strains and experiences concerning the intricate scleroglucan scaling-up will be also herein outlined. PMID:26528259

  5. New challenges in downstream retail markets

    International Nuclear Information System (INIS)

    The role and purposes of deregulation in the natural gas industry and the way in which downstream markets operate today were reviewed. The question of what form deregulation will take in the future, and how it will affect market participants was also addressed. Load imbalance has been identified as the most significant system inefficiency. It was argued that as long as LCDs hold control over the imbalances, end-users will be in a position where they will have no control over a variable which can significantly affect their cost. It is this lack of control that can be viewed as a system inefficiency. It was suggested that in the future deregulation will focus on load balancing, and will support the continued development of a retail market for products and services which exist independently of the wholesale market. Security of supply and control of the transportation and storage assets were identified as the principal issues associated with end-user customers gaining more control over their gas accounts

  6. Audio power amplifier design handbook

    CERN Document Server

    Self, Douglas

    2013-01-01

    This book is essential for audio power amplifier designers and engineers for one simple reason...it enables you as a professional to develop reliable, high-performance circuits. The Author Douglas Self covers the major issues of distortion and linearity, power supplies, overload, DC-protection and reactive loading. He also tackles unusual forms of compensation and distortion produced by capacitors and fuses. This completely updated fifth edition includes four NEW chapters including one on The XD Principle, invented by the author, and used by Cambridge Audio. Cro

  7. Cathode-follower power amplifier

    International Nuclear Information System (INIS)

    In circular accelerators and particularly in storage rings it is essential that the total impedance, as seen by the beam, be kept below some critical value. A model of the accelerating system was built using a single-ended cathode-follower amplifier driving a ferrite-loaded cavity. The system operated at 234.5 kHz with a peak output voltage of +-10 kV on the gap. The dynamic output impedance, as measured on the gap, was < 15 ohms

  8. Design and Characterization of the Next Generation Nanowire Amplifiers

    Directory of Open Access Journals (Sweden)

    Sotoudeh Hamedi-Hagh

    2008-01-01

    Full Text Available Vertical nanowire surrounding gate field effect transistors (SGFETs provide full gate control over the channel to eliminate short-channel effects. This paper presents design and characterization of a differential pair amplifier using NMOS and PMOS SGFETs with a 10 nm channel length and a 2 nm channel radius. The amplifier dissipates 5 μW power and provides 5 THz bandwidth with a voltage gain of 16, a linear output voltage swing of 0.5 V, and a distortion better than 3% from a 1.8 V power supply and a 20 aF capacitive load. The 2nd- and 3rd-order harmonic distortions of the amplifier are −40 dBm and −52 dBm, respectively, and the 3rd-order intermodulation is −24 dBm for a two-tone input signal with 10 mV amplitude and 10 GHz frequency spacing. All these parameters indicate that vertical nanowire surrounding gate transistors are promising candidates for the next generation high-speed analog and VLSI technologies.

  9. Dependence of mountain moisture retention on downstream saturation

    CERN Document Server

    November, L J

    2007-01-01

    We derive 1D steady equilibria for partially saturated downslope flow as a solution to the reposed vadose-zone problem. The equilibria are determined by two free parameters: a mean flow and a downstream saturation. Where there is no downstream saturation, a uniform outflow of constant saturation is obtained, but if an isolated zone of excess downstream saturation exists, the upstream flow speed is reduced and saturation increased. The saturated zone produces a capillary head jump that blocks the downward percolation. With a fully saturated downstream zone in medium clay mixtures, flow backs up more than 20 km projected vertically, but with 90% downstream saturation, the back up is reduced to less than a km. The drying of downstream saturated zones with the increased rate of mountain moisture outflow gives a viable quantitative explanation for the mysterious 56% unaccounted drop seen in the output of the southern NM La Luz / Fresnal Watershed at Alamogordo's upstream spring-box diversions.

  10. Pyrvinium attenuates Hedgehog signaling downstream of smoothened.

    Science.gov (United States)

    Li, Bin; Fei, Dennis Liang; Flaveny, Colin A; Dahmane, Nadia; Baubet, Valérie; Wang, Zhiqiang; Bai, Feng; Pei, Xin-Hai; Rodriguez-Blanco, Jezabel; Hang, Brian; Orton, Darren; Han, Lu; Wang, Baolin; Capobianco, Anthony J; Lee, Ethan; Robbins, David J

    2014-09-01

    The Hedgehog (HH) signaling pathway represents an important class of emerging developmental signaling pathways that play critical roles in the genesis of a large number of human cancers. The pharmaceutical industry is currently focused on developing small molecules targeting Smoothened (Smo), a key signaling effector of the HH pathway that regulates the levels and activity of the Gli family of transcription factors. Although one of these compounds, vismodegib, is now FDA-approved for patients with advanced basal cell carcinoma, acquired mutations in Smo can result in rapid relapse. Furthermore, many cancers also exhibit a Smo-independent activation of Gli proteins, an observation that may underlie the limited efficacy of Smo inhibitors in clinical trials against other types of cancer. Thus, there remains a critical need for HH inhibitors with different mechanisms of action, particularly those that act downstream of Smo. Recently, we identified the FDA-approved anti-pinworm compound pyrvinium as a novel, potent (IC50, 10 nmol/L) casein kinase-1α (CK1α) agonist. We show here that pyrvinium is a potent inhibitor of HH signaling, which acts by reducing the stability of the Gli family of transcription factors. Consistent with CK1α agonists acting on these most distal components of the HH signaling pathway, pyrvinium is able to inhibit the activity of a clinically relevant, vismodegib -resistant Smo mutant, as well as the Gli activity resulting from loss of the negative regulator suppressor of fused. We go on to demonstrate the utility of this small molecule in vivo, against the HH-dependent cancer medulloblastoma, attenuating its growth and reducing the expression of HH biomarkers. PMID:24994715

  11. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

    DEFF Research Database (Denmark)

    Bracken, Adrian P; Pasini, Diego; Capra, Maria;

    2003-01-01

    a large set of human tumors. These results raise the question whether EZH2 is a marker of proliferation or if it is actually contributing to tumor formation. Significantly, we propose that EZH2 is a bona fide oncogene, since we find that ectopic expression of EZH2 is capable of providing a...

  12. YANG-MILLS FIELD AMPLIFIER

    Directory of Open Access Journals (Sweden)

    Trunev A. P.

    2015-09-01

    Full Text Available The article presents a project of the Yang-Mills amplifier. Amplifier model is a multilayer spherical shell with increasing density towards the center. In the center of the amplifier is the core of high-density material. It is shown that in such a system, the amplitude of the Yang-Mills waves rises from the periphery to the center of several orders of magnitude. The role of the Yang-Mills field in the processes occurring in the nuclei of galaxies, stars and planets is discussed. The data modeling to strengthen the Yang-Mills field in the bowels of the planet, with an atomic explosion, and in some special devices such as the voltaic pile. To describe the mechanism of amplification chromodynamics field used as accurate results in Yang-Mills theory and numerical models developed based on an average and the exact equations as well. Among the exact solutions of the special role played by the centralsymmetric metric describing the contribution of the Yang-Mills field in the speed of recession of galaxies. Among the approximate numerical models can be noted the eight-scalar model we have developed for the simulation of non-linear color oscillations and chaos in the Yang-Mills theory. Earlier models were investigated spatio-temporal oscillations of the YangMills theory in the case of three and eight colors. The results of numerical simulation show that the nonlinear interaction does not lead to a spatial mixing of colors as it might be in the case of turbulent diffusion. Depending on the system parameters there is a suppression of the amplitude of the oscillations the first three by five colors or vice versa. The kinetic energy fluctuations or shared equally between the color components, or dominated by the kinetic energy of repressed groups of colors. In the present study, we found that amplification chromodynamic field leads to a sharp increase in the amplitude of the suppressed color, which can lead to an increase in entropy, excitation of nuclear

  13. Amplified CWDM-based Next Generation Broadband Access Networks

    Science.gov (United States)

    Peiris, Sasanthi Chamarika

    The explosive growth of both fixed and mobile data-centric traffic along with the inevitable trend towards all-IP/Ethernet transport protocols and packet switched networks will ultimately lead to an all-packet-based converged fixed-mobile optical transport network from the core all the way out to the access network. To address the increasing capacity and speed requirements in the access networks, Wavelength-Division Multiplexed (WDM) and/or Coarse WDM (CWDM)-based Passive Optical Networks (PONs) are expected to emerge as the next-generation optical access infrastructures. However, due to several techno-economic hurdles, CWDM-PONs are still considered an expensive solution and have not yet made any significant inroads into the current access area. One of the key technology hurdles is the scalability of the CWDM-based PONs. Passive component optical insertion losses limit the reach of the network or the number of served optical network units (ONUs). In the recent years, optical amplified CWDM approaches have emerged and new designs of optical amplifiers have been proposed and demonstrated. The critical design parameter for these amplifiers is the very wide optical amplification bandwidth (e.g., 340 nm combined for both directions). The objective of this PhD dissertation work is first to engineer ring and tree-ring based PON architectures that can achieve longer unamplified PON reach and/or provide service to a greater number of ONUs and customers. Secondly is to develop new novel optical amplifier schemes to further address the scalability limitation of the CWDM-based PONs. Specifically, this work proposes and develops novel ultra wide-band hybrid Raman-Optical parametric amplifier (HROPA) schemes that operate over nearly the entire specified CWDM band to provide 340 nm bidirectional optical gain bandwidth over the amplified PON's downstream and upstream CWDM wavelength bands (about 170 nm in each direction). The performance of the proposed HROPA schemes is assessed

  14. Transverse pumped laser amplifier architecture

    Science.gov (United States)

    Bayramian, Andrew James; Manes, Kenneth; Deri, Robert; Erlandson, Al; Caird, John; Spaeth, Mary

    2013-07-09

    An optical gain architecture includes a pump source and a pump aperture. The architecture also includes a gain region including a gain element operable to amplify light at a laser wavelength. The gain region is characterized by a first side intersecting an optical path, a second side opposing the first side, a third side adjacent the first and second sides, and a fourth side opposing the third side. The architecture further includes a dichroic section disposed between the pump aperture and the first side of the gain region. The dichroic section is characterized by low reflectance at a pump wavelength and high reflectance at the laser wavelength. The architecture additionally includes a first cladding section proximate to the third side of the gain region and a second cladding section proximate to the fourth side of the gain region.

  15. Locoregional MYCN-amplified neuroblastoma.

    Science.gov (United States)

    Morales La Madrid, Andres; Volchenboum, Samuel; Gastier-Foster, Julie M; Pyatt, Robert; Liu, Don; Pytel, Peter; Lavarino, Cinzia; Rodriguez, Eva; Cohn, Susan L

    2012-10-01

    MYCN-amplification is strongly associated with other high-risk prognostic factors and poor outcome in neuroblastoma. Infrequently, amplification of MYCN has been identified in localized tumors with favorable biologic features. Outcome for these children is difficult to predict and optimal treatment strategies remain unclear. We report a 5-month-old who presented with an MYCN-amplified INSS stage 3, pelvic neuroblastoma. The tumor had favorable histology, hyperdiploidy, and lacked 1p36 and 11q23 aberrations. Although the patient met the criteria for high-risk neuroblastoma, because of the discordant prognostic markers we elected to treat her according to an intermediate-risk protocol. She remains event-free more than 18 months.

  16. Linearisation of RF Power Amplifiers

    DEFF Research Database (Denmark)

    Nielsen, Per Asbeck

    2001-01-01

    This thesis deals with linearisation techniques of RF power amplifiers (PA), PA design techniques and integration of the necessary building blocks in a CMOS technology. The opening chapters introduces the theory of transmitter architectures, RF-signal representation and the principles of digital...... of linearisation systems with focus on polar modulation feedback, and a chip oriented part focusing on integrating of separate building blocks of the system on a chip. The system oriented part of this thesis deals with analog feedback linearisation systems. The Polar modulation feedback system is compared...... that utilize properties of the polar loop are presented. Analysis of the envelope feedback loop shows some fundamental limitations of the loop gain and the loop bandwidth due to the varying PA gain. Based on these observation a set of design guidelines for an envelope feedback loop is given. The guidelines...

  17. Optical latches using optical amplifiers

    Science.gov (United States)

    Li, Wenbo; Hu, Hongyu; Dutta, Niloy K.

    2013-05-01

    Optical latches are important for a wide range of applications including communication systems, optical logic systems, optical random access memory (RAM) and encryption. All optical logic operations using quantum dot (QD) based semiconductor optical amplifier (SOA) and Mach-Zehnder interferometer (MZI) have been studied. The building block of an optical latch such as NAND gate has been fabricated and their operation experimentally demonstrated at ~ 80 GHz. A rate equation model has been developed for the QD-SOA-MZI and it has been used to analyze the Boolean logic operation. The model has been used to analyze the Set-Reset (S-R) latch and the D-Flip-Flop (DFF) devices. The DFF is the basic device for building larger logic circuits. The results show that the latches would work to speeds of ~ 250 Gb/s.

  18. An Implantable CMOS Amplifier for Nerve Signals

    DEFF Research Database (Denmark)

    Nielsen, Jannik Hammel; Lehmann, Torsten

    2001-01-01

    on the amplifier input nodes. The method for signal recovery from noisy nerve signals is presented. A prototype amplifier is realized in a standard digital 0.5 μm CMOS single poly, n-well process. The prototype amplifier features a gain of 80 dB over a 3.6 kHz bandwidth, a CMRR of more than 87 dB and a PSRR...

  19. Enhanced Gain in Photonic Crystal Amplifiers

    DEFF Research Database (Denmark)

    Ek, Sara; Semenova, Elizaveta; Hansen, Per Lunnemann;

    2012-01-01

    study of a 1 QW photonic crystal amplifier. Net gain is achieved which enables laser oscillation in photonic crystal micro cavities. The ability to freely tailor the dispersion in a semiconductor optical amplifier makes it possible to raise the optical gain considerably over a certain bandwidth. These...... results are promising for short and efficient semiconductor optical amplifiers. This effect will also benefit other devices, such as mode locked lasers....

  20. DOWNSTREAM ECOCIDE FROM UPSTREAM WATER PIRACY

    Directory of Open Access Journals (Sweden)

    Miah Muhammad Adel

    2012-01-01

    Full Text Available Upstream India and downstream Bangladesh share more than 50 international rivers. India has set up water diversion constructions in more than 50% of these rivers, the largest one being on the Bangladesh’s northwest upon the Ganges River, puts Bangladesh’s Gangetic ecosystem at stake. In some border rivers, India has set up groins on her side of river banks. Also, Indian side pumps Bangladesh river water stealthily from border-rivers. Further, India is constructing another dam and reservoir upstream on the Barak River on the northeast of Bangladesh. Furthermore, India has chalked out a grand plan for river networking. Exploration has been made to assess the degree of the ecosystem degradation both inland and on the coast due to all water diversion constructions around the border, except for the Tipaimukh Dam in which case estimation of projected ecosystem degradation has been mentioned. Finally, Indian grand plan of river networking plan has been briefly touched upon. Site visitations, observations, surveys, measurements and interviews of professionals were made in the project country. Relevant literatures on this issue were reviewed in electronic and print databases. Related published articles in electronic and print media were systematically searched following the key words for the case. Finally, both electronic and print news media have been closely followed to know the latest developments on this issue. The reduced flow of the Ganges in Bangladesh has caused scarcity of fresh water, species endangerment and extinction, obstruction to livestock raising, loss of livelihoods, people’s displacement, changes in crop production, reduction in navigable routes, extreme weather, increased flood occurrences, scarcity of potable water, groundwater contamination, reduction in coastal sediment deposition, deterioration of the Ganges water quality and inland intrusion of saline water front. Water diversion constructions in other rivers have

  1. Reflection amplifiers in self-regulated learning

    NARCIS (Netherlands)

    Verpoorten, Dominique

    2012-01-01

    Verpoorten, D. (2012). Reflection amplifiers in self-regulated learning. Doctoral thesis. November, 9, 2012, Heerlen, The Netherlands: Open Universiteit (CELSTEC). Datawyse / Universitaire Pers Maastricht.

  2. Design of an 1800nm Raman amplifier

    DEFF Research Database (Denmark)

    Svane, Ask Sebastian; Rottwitt, Karsten

    2013-01-01

    We present the experimental results for a Raman amplifier that operates at 1810 nm and is pumped by a Raman fiber laser at 1680 nm. Both the pump laser and the Raman amplifier is polarization maintaining. A challenge when scaling Raman amplifiers to longer wavelengths is the increase...... performance of the amplifier is also investigated for both configurations. Our results show an on/off gain exceeding 20 dB at 1810 nm for which the obtained effective noise figure is below 3 dB....

  3. Dynamics of Soliton Cascades in Fiber Amplifiers

    CERN Document Server

    Arteaga-Sierra, F R; Agrawal, Govind P

    2016-01-01

    We study numerically the formation of cascading solitons when femtosecond optical pulses are launched into a fiber amplifier with less energy than required to form a soliton of equal duration. As the pulse is amplified, cascaded fundamental solitons are created at different distances, without soliton fission, as each fundamental soliton moves outside the gain bandwidth through the Raman-induced spectral shifts. As a result, each input pulse creates multiple, temporally separated, ultrashort pulses of different wavelengths at the amplifier output. The number of pulses depends not only on the total gain of the amplifier but also on the width of input pulses.

  4. Downstream Evolution of Longitudinal Embedded Vortices with Helical Structure

    DEFF Research Database (Denmark)

    Velte, Clara Marika; Okulov, Valery; Hansen, Martin Otto Laver

    2009-01-01

    In the present work the downstream development of device induced vortices with helical symmetry embedded in wall bounded flow on a bump is studied with the aid of Stereoscopic Particle Image Velocimetry (SPIV). The downstream evolution of characteristic parameters of helical vortices is studied...

  5. Distributed feedback laser amplifiers combining the functions of amplifiers and channel filters

    DEFF Research Database (Denmark)

    Wang, Z.; Durhuus, T.; Mikkelsen, Benny;

    1994-01-01

    A dynamic model for distributed feedback amplifiers, including the mode coupled equations and the carrier rate equation, is established. The presented mode coupled equations have taken into account the interaction between fast changing optical signal and the waveguide with corrugations. By showin...... the possibility of amplifying 100 ps pulses without pulse broadening, we anticipate that a distributed feedback amplifier can be used as a combined amplifier and channel filter in high bit rate transmission systems....

  6. Amplified spontaneous emission and its restraint in a terawatt Ti:sapphire amplifier

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Amplified spontaneous emission (ASE) and its restraint in a femtosecond Ti: sapphire chirped_pulse amplifier were investigated. The noises arising from ASE were effectively filtered out in the spatial, temporal and spectral domain. Pulses as short as 38 fs were amplified to peak power of 1.4 TW. The power ratio between the amplified femtosecond pulse and the ASE was higher than 106:1.

  7. An Implantable CMOS Amplifier for Nerve Signals

    DEFF Research Database (Denmark)

    Nielsen, Jannik Hammel; Lehmann, Torsten

    2003-01-01

    . A continuous-time current-steering offset-compensation technique is utilized in order to minimize the noise contribution and to minimize dynamic impact on the amplifier input nodes. The method for signal recovery from noisy nerve signals is presented. A prototype amplifier is realized in a standard digital 0...

  8. Self-pulsation in Raman fiber amplifiers

    DEFF Research Database (Denmark)

    Pedersen, Martin Erland Vestergaard; Ott, Johan Raunkjær; Rottwitt, Karsten

    2009-01-01

    Dynamic behavior caused by Brillouin scattering in Raman fiber amplifiers is studied. Modes of self-pulsation steady state oscillations are found. Their dependence on amplification scheme is demonstrated.......Dynamic behavior caused by Brillouin scattering in Raman fiber amplifiers is studied. Modes of self-pulsation steady state oscillations are found. Their dependence on amplification scheme is demonstrated....

  9. Waveguide optical amplifier for telecom applications

    OpenAIRE

    Taccheo, Stefano; Zannin, Marcelo; Ennser, Karin; Careglio, Davide; Solé Pareta, Josep; Aracil Rico, Javier

    2009-01-01

    In this paper we review progress in optical gain clamped waveguide amplifiers for applications to optical communications. We demonstrate that compact waveguide devices may offer advantages compared to standard fiber amplifiers. In particular we focus on the application of gain clamping and optical burst switching networks where physical impairments may occur due to variation of the input power. Peer Reviewed

  10. BROADBAND TRAVELLING WAVE SEMICONDUCTOR OPTICAL AMPLIFIER

    DEFF Research Database (Denmark)

    2010-01-01

    Broadband travelling wave semiconductor optical amplifier (100, 200, 300, 400, 800) for amplification of light, wherein the amplifier (100, 200, 300, 400, 800) comprises a waveguide region (101, 201, 301, 401, 801) for providing confinement of the light in transverse directions and adapted...

  11. Design and performance of the beamlet amplifiers

    Energy Technology Data Exchange (ETDEWEB)

    Erlandson, A.C.; Rotter, M.D.; Frank, M.D.; McCracken, R.W.

    1996-06-01

    In future laser systems, such as the National Ignition Facility (NIF), multi-segment amplifiers (MSAs) will be used to amplify the laser beam to the required levels. As a prototype of such a laser architecture, the authors have designed, built, and tested flash-lamp-pumped, Nd:Glass, Brewster-angle slab MSAs for the Beamlet project. In this article, they review the fundamentals of Nd:Glass amplifiers, describe the MSA geometry, discuss parameters that are important in amplifier design, and present our results on the characterization of the Beamlet MSAs. In particular, gain and beam steering measurements show that the Beamlet amplifiers meet all optical performance specifications and perform close to model predictions.

  12. Qubit readout with a directional parametric amplifier

    Science.gov (United States)

    Sliwa, K. M.; Abdo, B.; Narla, A.; Shankar, S.; Hatridge, M.; Frunzio, L.; Schoelkopf, R. J.; Devoret, M. H.

    2014-03-01

    Josephson junction based quantum limited parametric amplifiers play an essential role in superconducting qubit measurements. These measurements necessitate circulators and isolators between the amplifier and qubit to add directionality and/or isolation. Unfortunately, this extra hardware limits both quantum measurement efficiency and experimental scalability. Here we present a quantum-limited Josephson-junction-based directional amplifier (JDA) based on a novel coupling between two nominally identical Josephson parametric converters (JPCs). The device achieves a forward gain of 11 dB with a 15 MHz dynamical bandwidth, but higher gains are possible at the expense of bandwidth. We also present measurements of a transmon qubit made with the JDA, and show minimal measurement back-action despite the absence of any isolator or circulator before the amplifier. These results provide a first step toward realizing on-chip integration of qubits and parametric amplifiers. Work supported by: IARPA, ARO, and NSF.

  13. Detection of Non-Amplified Genomic DNA

    CERN Document Server

    Corradini, Roberto

    2012-01-01

    This book offers a state-of-the-art overview on non amplified DNA detection methods and provides chemists, biochemists, biotechnologists and material scientists with an introduction to these methods. In fact all these fields have dedicated resources to the problem of nucleic acid detection, each contributing with their own specific methods and concepts. This book will explain the basic principles of the different non amplified DNA detection methods available, highlighting their respective advantages and limitations. The importance of non-amplified DNA sequencing technologies will be also discussed. Non-amplified DNA detection can be achieved by adopting different techniques. Such techniques have allowed the commercialization of innovative platforms for DNA detection that are expected to break into the DNA diagnostics market. The enhanced sensitivity required for the detection of non amplified genomic DNA has prompted new strategies that can achieve ultrasensitivity by combining specific materials with specifi...

  14. Ultrafast disk lasers and amplifiers

    Science.gov (United States)

    Sutter, Dirk H.; Kleinbauer, Jochen; Bauer, Dominik; Wolf, Martin; Tan, Chuong; Gebs, Raphael; Budnicki, Aleksander; Wagenblast, Philipp; Weiler, Sascha

    2012-03-01

    Disk lasers with multi-kW continuous wave (CW) output power are widely used in manufacturing, primarily for cutting and welding applications, notably in the automotive industry. The ytterbium disk technology combines high power (average and/or peak power), excellent beam quality, high efficiency, and high reliability with low investment and operating costs. Fundamental mode picosecond disk lasers are well established in micro machining at high throughput and perfect precision. Following the world's first market introduction of industrial grade 50 W picosecond lasers (TruMicro 5050) at the Photonics West 2008, the second generation of the TruMicro series 5000 now provides twice the average power (100 W at 1030 nm, or 60 W frequency doubled, green output) at a significantly reduced footprint. Mode-locked disk oscillators achieve by far the highest average power of any unamplified lasers, significantly exceeding the 100 W level in laboratory set-ups. With robust long resonators their multi-microjoule pulse energies begin to compete with typical ultrafast amplifiers. In addition, significant interest in disk technology has recently come from the extreme light laser community, aiming for ultra-high peak powers of petawatts and beyond.

  15. MATHEMATICAL MODELLING OF DEGRADATION AND FLUVIAL PROCESS DOWNSTREAM RESERVOIRS

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    To research into the problem of degradation and fluvial process downstream reservoirs and its influence on flood control and navigation, a 1-D mathematical model of degradation and fluvial process downstream the reservoir was established in this paper. The non-equilibrium transport of non-uniform suspended load, the non-uniform bedload transport and bed material sorting were considered in the model. Some techniques were suggested for some problems in calculation, such as the effective suspended load carrying capacity of the different reaches of bed materials, the coefficient of suspended load carrying capacity, the recovering coefficient of carrying capacity, the mixed layer thickness, the bedload transport width, bifurcation and confluence of main and branch channel, and the distribution of deposition and erosion along the cross section, etc. The model was tested by the data of degradation downstream the Danjiangkou reservoir on the Hanjiang River and the data of degradation downstream the Gezhouba Project on the Yangtze River.

  16. Corrosion rate and downstream effect in liquid metal systems

    International Nuclear Information System (INIS)

    Results of experiments performed, especially of runs 1.10 and 1.12 have been evaluated with respect to the downstream effect in isothermal test sections in sodium at 1000 K. It is evident that there is not dependence of the selective Ni loss on position. This loss will be reduced considerably with high Ni concentration in sodium. The downstream function is influenced by different causes for short and extended exposure periods. Up to 400h Cr, together with impurities in sodium dominates the downstream effect. After longer exposure periods the steel surface will become equilibrated with respect to sodium conditions and the downstream effect will be dominated by elemental dissolution, essentially of Fe and saturation of dissolved elements in sodium. (author)

  17. Symmetric 10 Gb/s wavelength reused bidirectional RSOA based WDM-PON with DPSK modulated downstream and OFDM modulated upstream signals

    Science.gov (United States)

    Choudhury, Pallab K.; Khan, Tanvir Zaman

    2016-08-01

    A 10 Gb/s bidirectional wavelength division multiplexing passive optical network (WDM-PON) with reflective semiconductor optical amplifier (RSOA) based colorless optical network unit (ONU) is proposed and analyzed for next generation gigabit class optical access network. Differential phase shift keying (DPSK) modulated signal is used in downstream and further reused as a seeding wavelength for upstream data modulation. By exploiting the constant envelope property of DPSK seed signal, the re-modulation noise in upstream receiver is effectively minimized without employing any constraint on extinction ratio of downstream signal. Orthogonal frequency division multiplexing (OFDM) signal is used in upstream transmission to overcome the limited bandwidth (∼1 GHz) response of RSOA remodulation. The results show that the proposed 10 Gb/s symmetric WDM-PON can achieve good performance over 25 km fiber transmission with error free operation in downstream and bit error rate (BER) lower than forward error correction (FEC) limit in upstream.

  18. Downstream influence scaling of turbulent flow past expansion corners

    Science.gov (United States)

    Lu, Frank K.; Chung, Kung-Ming

    1992-01-01

    Previous studies of the high-speed viscous inviscid interaction between a turbulent boundary layer and an expansion at a convex corner have noted that surface pressure decreases toward the downstream inviscid value yielded by a Prandtl-Meyer expansion. A downstream influence on the corner is presently identified which is based on the mean surface pressure distribution; a scaling law is proposed for this distance.

  19. Modelling Downstream Effects in the Presence of Technological Change

    OpenAIRE

    Duncan Mortimer

    2008-01-01

    Downstream effects are typically evaluated given current technology and current practice patterns rather than for technology and practice patterns that will be available at the time when downstream effects accrue. Where a relatively short time horizon can be expected to capture all relevant costs and effects, the current approach is unlikely to introduce substantial error into estimates of the costs and benefits attributed to an intervention; the estimates will remain valid so long as the con...

  20. MATHEMATICAL MODEL OF RIVER BED CHANGE DOWNSTREAM OF XIAOLANGDI RESERVOIR

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    A mathematical model of river bed change downstream of the Xiaolangdi Reservoir was developed based on the most recent achievement of sediment theory in the Yellow River. The model was verified by the comparison of computed results and measured data from 1986 to 1996. Numerical prediction of the erosion and deposition downstream of the Xiaolangdi Reservoir in its first operation year was carried out, and a series of suggestions were given for reservoir operation mode in its early operation period.

  1. Downstream processing of Isochrysis galbana: a step towards microalgal biorefinery

    OpenAIRE

    Gilbert-López, Bienvenida; Mendiola, José A.; Fontecha, Javier; SIJTSMA Lolke; Cifuentes, Alejandro; Herrero, Miguel; Ibáñez, Elena; van den Broek, Lambertus A. M.

    2015-01-01

    An algae-based biorefinery relies on the efficient use of algae biomass through its fractionation of several valuable/bioactive compounds that can be used in industry. If this biorefinery includes green platforms as downstream processing technologies able to fulfill the requirements of green chemistry, it will end-up with sustainable processes. In the present study, a downstream processing platform has been developed to extract bioactive compounds from the microalga Isochrysis galbana using v...

  2. Effect of Soliton Propagation in Fiber Amplifiers

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The propagation of optical solitons in fiber amplifiers is discussed by considering a model that includes linear high order dispersion, two-photon absorption, nonlinear high-order dispersion, self-induced Ramam and five-order nonlinear effects. Based on travelling wave method, the solutions of the nonlinear Schrdinger equations, and the influence on soliton propagation as well as high-order effect in the fiber amplifier are discussed in detail. It is found that because of existing five-order nonlinear effect, the solution is not of secant hyperbola type, but shows high gain state of the fiber amplifier which is very favourable to the propagation of solitons.

  3. Quantum electronics maser amplifiers and oscillators

    CERN Document Server

    Fain, V M; Sanders, J H

    2013-01-01

    Quantum Electronics, Volume 2: Maser Amplifiers and Oscillators deals with the experimental and theoretical aspects of maser amplifiers and oscillators which are based on the principles of quantum electronics. It shows how the concepts and equations used in quantum electronics follow from the basic principles of theoretical physics.Comprised of three chapters, this volume begins with a discussion on the elements of the theory of quantum oscillators and amplifiers working in the microwave region, along with the practical achievements in this field. Attention is paid to two-level paramagnetic ma

  4. Laser Cooled High-Power Fiber Amplifier

    OpenAIRE

    Nemova, Galina

    2009-01-01

    A theoretical model for laser cooled continuous-wave fiber amplifier is presented. The amplification process takes place in the Tm3+-doped core of the fluoride ZBLAN (ZrF4-BaF2-LaF3-AlF3-NaF) glass fiber. The cooling process takes place in the Yb3+:ZBLAN fiber cladding. It is shown that for each value of the pump power and the amplified signal there is a distribution of the concentration of the Tm3+ along the length of the fiber amplifier, which provides its athermal operation. The influence ...

  5. Fundamentals of RF and microwave transistor amplifiers

    CERN Document Server

    Bahl, Inder J

    2009-01-01

    A Comprehensive and Up-to-Date Treatment of RF and Microwave Transistor Amplifiers This book provides state-of-the-art coverage of RF and microwave transistor amplifiers, including low-noise, narrowband, broadband, linear, high-power, high-efficiency, and high-voltage. Topics covered include modeling, analysis, design, packaging, and thermal and fabrication considerations. Through a unique integration of theory and practice, readers will learn to solve amplifier-related design problems ranging from matching networks to biasing and stability. More than 240 problems are included to help read

  6. Modeling Neutral Densities Downstream of a Gridded Ion Thruster

    Science.gov (United States)

    Soulas, George C.

    2010-01-01

    The details of a model for determining the neutral density downstream of a gridded ion thruster are presented. An investigation of the possible sources of neutrals emanating from and surrounding a NEXT ion thruster determined that the most significant contributors to the downstream neutral density include discharge chamber neutrals escaping through the perforated grids, neutrals escaping from the neutralizer, and vacuum facility background neutrals. For the neutral flux through the grids, near- and far-field equations are presented for rigorously determining the neutral density downstream of a cylindrical aperture. These equations are integrated into a spherically-domed convex grid geometry with a hexagonal array of apertures for determining neutral densities downstream of the ion thruster grids. The neutrals escaping from an off-center neutralizer are also modeled assuming diffuse neutral emission from the neutralizer keeper orifice. Finally, the effect of the surrounding vacuum facility neutrals is included and assumed to be constant. The model is used to predict the neutral density downstream of a NEXT ion thruster with and without neutralizer flow and a vacuum facility background pressure. The impacts of past simplifying assumptions for predicting downstream neutral densities are also examined for a NEXT ion thruster.

  7. Downstream-based Scheduling for Energy Conservation in Green EPONs

    KAUST Repository

    Chen, Shen

    2012-05-01

    Maximizing the optical network unit’s (ONU) sleep time is an effective approach for achieving maximum energy conservation in green Ethernet passive optical networks (EPONs). While overlapping downstream and upstream ONU transmissions can maximize the ONU sleep time, it jeopardizes the quality of service (QoS) performance of the network, especially for downstream traffic in case the overlapping is based on the upstream time slot. In this paper, we study the downstream traffic performance in green EPONs under the limited service discipline and the upstream-based overlapped time window. Specifically, we first derive the expected mean packet delay, and then present a closed-form expression of the ONU sleep time, setting identical upstream/downstream transmission cycle times based on a maximum downstream traffic delay re-quirement. With the proposed system model, we present a novel downstream bandwidth allocation scheme for energy conservation in green EPONs. Simulation results verify the proposed model and highlight the advantages of our scheme over conventional approaches.

  8. Sensor/amplifier for weak light sources

    Science.gov (United States)

    Desmet, D. J.; Jason, A. J.; Parr, A. C.

    1980-01-01

    Light sensor/amplifier circuit detects weak light converts it into strong electrical signal in electrically noisy environment. Circuit is relatively simple and uses inexpensive, readily available components. Device is useful in such applications as fire detection and photographic processing.

  9. High Energy Single Frequency Resonant Amplifier Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR phase I project proposes a single frequency high energy resonant amplifier for remote sensing. Current state-of-art technologies can not provide all...

  10. Electoral Systems and Candidate Selection

    NARCIS (Netherlands)

    Hazan, Reuven Y.; Voerman, Gerrit

    2006-01-01

    Electoral systems at the national level and candidate selection methods at the party level are connected, maybe not causally but they do influence each other. More precisely, the electoral system constrains and conditions the parties' menu of choices concerning candidate selection. Moreover, in ligh

  11. Multiple excitation regenerative amplifier inertial confinement system

    International Nuclear Information System (INIS)

    The invention relates to apparatus and methods for producing high intensity laser radiation generation which is achieved through an optical amplifier-storage ring design. One or two synchronized, counterpropagating laser pulses are injected into a regenerative amplifier cavity and amplified by gain media which are pumped repetitively by electrical or optical means. The gain media excitation pulses are tailored to efficiently amplify the laser pulses during each transit. After the laser pulses have been amplified to the desired intensity level, they are either switched out of the cavity by some switch means, as for example an electro-optical device, for any well known laser end uses, or a target means may be injected into the regenerative amplifier cavity in such a way as to intercept simultaneously the counterpropagating laser pulses. One such well known end uses to which this invention is intended is for production of high density and temperature plasmas suitable for generating neutrons, ions and x-rays and for studying matter heated by high intensity laser radiation

  12. Proposal of Switching Power Amplifier Using Small Capacity Linear Amplifier and LC Filter

    Science.gov (United States)

    Kamada, Jo; Funato, Hirohito; Ogasawara, Satoshi

    The higher efficiency and the low noise in output voltage and current has been required in some applications, i.e. audio-video equipment, medical equipment and so on. This paper proposes a power amplifier in which a PWM inverter is used as a main circuit. In the proposed power amplifier, a hybrid filter composed of a simple and general LC filter and a small capacity linear amplifier is connected to the output of the inverter. The linear amplifier is inserted in series to the filter capacitor to improve the filtering effect of the LC filter. Switching ripples and LC resonances are considerably suppressed by controlling the amplifier using the proposed method and a low distortion switching power amplifier is realized. The effects of the proposal circuit are verified by simulations and experiments. As a result, the proposed circuit achieves low noise about THD=0.68% in simulation and THD=1.7% in experiment.

  13. Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer.

    Science.gov (United States)

    Canonici, Alexandra; Gijsen, Merel; Mullooly, Maeve; Bennett, Ruth; Bouguern, Noujoude; Pedersen, Kasper; O'Brien, Neil A; Roxanis, Ioannis; Li, Ji-Liang; Bridge, Esther; Finn, Richard; Siamon, Dennis; McGowan, Patricia; Duffy, Michael J; O'Donovan, Norma; Crown, John; Kong, Anthony

    2013-10-01

    Trastuzumab has been shown to improve the survival outcomes of HER2 positive breast cancer patients. However, a significant proportion of HER2-positive patients are either inherently resistant or develop resistance to trastuzumab. We assessed the effects of neratinib, an irreversible panHER inhibitor, in a panel of 36 breast cancer cell lines. We further assessed its effects with or without trastuzumab in several sensitive and resistant breast cancer cells as well as a BT474 xenograft model. We confirmed that neratinib was significantly more active in HER2-amplified than HER2 non-amplified cell lines. Neratinib decreased the activation of the 4 HER receptors and inhibited downstream pathways. However, HER3 and Akt were reactivated at 24 hours, which was prevented by the combination of trastuzumab and neratinib. Neratinib also decreased pHER2 and pHER3 in acquired trastuzumab resistant cells. Neratinib in combination with trastuzumab had a greater growth inhibitory effect than either drug alone in 4 HER2 positive cell lines. Furthermore, trastuzumab in combination with neratinib was growth inhibitory in SKBR3 and BT474 cells which had acquired resistance to trastuzumab as well as in a BT474 xenograft model. Innately trastuzumab resistant cell lines showed sensitivity to neratinib, but the combination did not enhance response compared to neratinib alone. Levels of HER2 and phospho-HER2 showed a direct correlation with sensitivity to neratinib. Our data indicate that neratinib is an effective anti-HER2 therapy and counteracted both innate and acquired trastuzumab resistance in HER2 positive breast cancer. Our results suggest that combined treatment with trastuzumab and neratinib is likely to be more effective than either treatment alone for both trastuzumab-sensitive breast cancer as well as HER2-positive tumors with acquired resistance to trastuzumab. PMID:24009064

  14. Saturated Collision Amplifier reach extender for XGPON1 and TDM/DWDM PON.

    Science.gov (United States)

    von Lerber, Tuomo; Tervonen, Ari; Saliou, Fabienne; Le, Quang Trung; Chanclou, Philippe; Xia, Rui; Mattila, Marco; Weiershausen, Werner; Honkanen, Seppo; Küppers, Franko

    2011-12-12

    Saturated Collision Amplifier (SCA) is a novel amplification scheme that uses SOA saturation in order to maximize the output power and minimize the ASE noise and the polarization sensitivity. We demonstrate the SCA reach extension in a commercial single-wavelength XGPON1 prototype system where bidirectional optical budget of up to 50 dB is obtained. The traffic performances are compared between the SCA and the conventional SOA extender. The novel extension scheme is demonstrated also for two- and four-wavelength 10 Gbit/s unidirectional downstream configurations with 45 km and 100 km transmission distances with 58-dB maximum total optical budget for each wavelength. PMID:22274083

  15. Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling.

    Science.gov (United States)

    Lin, Zhengshi; Cantos, Raquel; Patente, Maria; Wu, Doris K

    2005-05-01

    Gbx2 is a homeobox-containing transcription factor that is related to unplugged in Drosophila. In mice, Gbx2 and Otx2 negatively regulate each other to establish the mid-hindbrain boundary in the neural tube. Here, we show that Gbx2 is required for the development of the mouse inner ear. Absence of the endolymphatic duct and swelling of the membranous labyrinth are common features in Gbx2-/- inner ears. More severe mutant phenotypes include absence of the anterior and posterior semicircular canals, and a malformed saccule and cochlear duct. However, formation of the lateral semicircular canal and its ampulla is usually unaffected. These inner ear phenotypes are remarkably similar to those reported in kreisler mice, which have inner ear defects attributed to defects in the hindbrain. Based on gene expression analyses, we propose that activation of Gbx2 expression within the inner ear is an important pathway whereby signals from the hindbrain regulate inner ear development. In addition, our results suggest that Gbx2 normally promotes dorsal fates such as the endolymphatic duct and semicircular canals by positively regulating genes such as Wnt2b and Dlx5. However, Gbx2 promotes ventral fates such as the saccule and cochlear duct, possibly by restricting Otx2 expression.

  16. Modeling downstream fining in sand-bed rivers. I: Formulation

    Science.gov (United States)

    Wright, S.; Parker, G.

    2005-01-01

    In this paper a numerical modeling formulation is presented for simulation of the development of the longitudinal profile and bed sediment distribution in sand-bed rivers. The objective of the model application, which is presented in the companion paper (Wright and Parker, 2005), is to study the development of two characteristics of large, low-slope, sand-bed rivers: (1) a downstream decrease in bed slope (i.e. concave upward longitudinal profile) and (2) a downstream decrease in characteristic bed sediment diameter (e.g. the median bed surface size D50). Three mechanisms that lead to an upward concave profile and downstream fining are included in the modeling formulation: (1) a delta prograding into standing water at the downstream boundary, (2) sea-level rise, and (3) tectonic subsidence. In the companion paper (Wright and Parker, 2005) the model is applied to simulate the development of the longitudinal profile and downstream fining in sand-bed rivers flowing into the ocean during the past 5000 years of relatively slow sea-level rise. ?? 2005 International Association of Hydraulic Engineering and Research.

  17. Mortality of zebra mussel, Dreissena polymorpha, veligers during downstream transport

    Science.gov (United States)

    Horvath, T.G.; Lamberti, G.A.

    1999-01-01

    1. Streams flowing from lakes which contain zebra mussels, Dreissena polymorpha, provide apparently suitable habitats for mussel colonization and downstream range expansion, yet most such streams contain few adult mussels. We postulated that mussel veligers experience high mortality during dispersal via downstream transport. They tested this hypothesis in Christiana Creek, a lake-outlet stream in south-western Michigan, U.S.A., in which adult mussel density declined exponentially with distance downstream. 2. A staining technique using neutral red was developed and tested to distinguish quickly live and dead veligers. Live and dead veligers were distinguishable after an exposure of fresh samples to 13.3 mg L-1 of neutral red for 3 h. 3. Neutral red was used to determine the proportion of live veligers in samples taken longitudinally along Christiana Creek. The proportion of live veligers (mean ?? SE) declined from 90 ?? 3% at the lake outlet to 40 ?? 8% 18 km downstream. 4. Veligers appear to be highly susceptible to damage by physical forces (e.g. shear), and therefore, mortality in turbulent streams could be an important mechanism limiting zebra mussel dispersal to downstream reaches. Predictions of zebra mussel spread and population growth should consider lake-stream linkages and high mortality in running waters.

  18. Downstream Yangtze River levels impacted by Three Gorges Dam

    Science.gov (United States)

    Wang, Jida; Sheng, Yongwei; Gleason, Colin J.; Wada, Yoshihide

    2013-12-01

    Changes in the Yangtze River level induced by large-scale human water regulation have profound implications on the inundation dynamics of surrounding lakes/wetlands and the integrity of related ecosystems. Using in situ measurements and hydrological simulation, this study reveals an altered Yangtze level regime downstream from the Three Gorges Dam (TGD) to the Yangtze estuary in the East China Sea as a combined result of (i) TGD’s flow regulation and (ii) Yangtze channel erosion due to reduced sediment load. During the average annual cycle of TGD’s regular flow control in 2009-2012, downstream Yangtze level variations were estimated to have been reduced by 3.9-13.5% at 15 studied gauging stations, manifested as evident level decrease in fall and increase in winter and spring. The impacts on Yangtze levels generally diminished in a longitudinal direction from the TGD to the estuary, with a total time lag of ˜9-12 days. Chronic Yangtze channel erosion since the TGD closure has lowered water levels in relation to flows at most downstream stations, which in turn counteracts the anticipated level increase by nearly or over 50% in winter and spring while reinforcing the anticipated level decrease by over 20% in fall. Continuous downstream channel erosion in the near future may further counteract the benefit of increased Yangtze levels during TGD’s water supplement in winter and accelerate the receding of inundation areas/levels of downstream lakes in fall.

  19. Critical effects of downstream boundary conditions on vortex breakdown

    Science.gov (United States)

    Kandil, Osama; Kandil, Hamdy A.; Liu, C. H.

    1992-01-01

    The unsteady, compressible, full Navier-Stokes (NS) equations are used to study the critical effects of the downstream boundary conditions on the supersonic vortex breakdown. The present study is applied to two supersonic vortex breakdown cases. In the first case, quasi-axisymmetric supersonic swirling flow is considered in a configured circular duct, and in the second case, quasi-axisymmetric supersonic swirling jet, that is issued from a nozzle into a supersonic jet of lower Mach number, is considered. For the configured duct flow, four different types of downstream boundary conditions are used, and for the swirling jet flow from the nozzle, two types of downstream boundary conditions are used. The solutions are time accurate which are obtained using an implicit, upwind, flux-difference splitting, finite-volume scheme.

  20. Rhizosecretion improves the production of Cyanovirin-N in Nicotiana tabacum through simplified downstream processing.

    Science.gov (United States)

    Madeira, Luisa M; Szeto, Tim H; Ma, Julian K-C; Drake, Pascal M W

    2016-07-01

    Rhizosecretion has many advantages for the production of recombinant pharmaceuticals, notably facile downstream processing from hydroponic medium. The aim of this study was to increase yields of the HIV microbicide candidate, Cyanovirin-N (CV-N), obtained using this production platform and to develop a simplified methodology for its downstream processing from hydroponic medium. Placing hydroponic cultures on an orbital shaker more than doubled the concentration of CV-N in the hydroponic medium compared to plants which remained stationary, reaching a maximum of approximately 20μg/ml in one week, which is more than 3 times higher than previously reported yields. The protein composition of the hydroponic medium, the rhizosecretome, was characterised in plants cultured with or without the plant growth regulator alpha-napthaleneacetic acid by LC-ESI-MS/MS, and CV-N was the most abundant protein. The issue of large volumes in the rhizosecretion system was addressed by using ion exchange chromatography to concentrate CV-N and partially remove impurities. The semi-purified CV-N was demonstrated to bind to HIV gp120 in an ELISA and to neutralise HIVBa-L with an IC50 of 6nM in a cell-based assay. Rhizosecretion is therefore a practicable and inexpensive method for the production of functional CV-N. PMID:26901579

  1. Transition duct with divided upstream and downstream portions

    Science.gov (United States)

    McMahan, Kevin Weston; LeBegue, Jeffrey Scott; Maldonado, Jaime Javier; Dillard, Daniel Jackson; Flanagan, James Scott

    2015-07-14

    Turbine systems are provided. In one embodiment, a turbine system includes a transition duct comprising an inlet, an outlet, and a duct passage extending between the inlet and the outlet and defining a longitudinal axis, a radial axis, and a tangential axis. The outlet of the transition duct is offset from the inlet along the longitudinal axis and the tangential axis. The duct passage includes an upstream portion extending from the inlet and a downstream portion extending from the outlet. The turbine system further includes a rib extending from an outer surface of the duct passage, the rib dividing the upstream portion and the downstream portion.

  2. Interaction of fan rotor flow with downstream struts

    Science.gov (United States)

    Obrien, W. F., Jr.; Reimers, S. L.; Richardson, S. W.

    1983-01-01

    The detailed unsteady pressure field produced on the rotor blades of an axial-flow fan by interaction with downstream struts was investigated. The experimental arrangement was similar to that found in the fan casings of turbofan aircraft engines. Acoustically significant pressure fluctuations were measured on both thy suction and pressure sides of the rotor blades for several positions of the downstream struts. The level of the observed interaction decreased with increased spacing of the struts behind the rotor. An inviscid flow analysis for the disturbance level is compared with trends of the measured results.

  3. High power, high beam quality regenerative amplifier

    Science.gov (United States)

    Hackel, L.A.; Dane, C.B.

    1993-08-24

    A regenerative laser amplifier system generates high peak power and high energy per pulse output beams enabling generation of X-rays used in X-ray lithography for manufacturing integrated circuits. The laser amplifier includes a ring shaped optical path with a limited number of components including a polarizer, a passive 90 degree phase rotator, a plurality of mirrors, a relay telescope, and a gain medium, the components being placed close to the image plane of the relay telescope to reduce diffraction or phase perturbations in order to limit high peak intensity spiking. In the ring, the beam makes two passes through the gain medium for each transit of the optical path to increase the amplifier gain to loss ratio. A beam input into the ring makes two passes around the ring, is diverted into an SBS phase conjugator and proceeds out of the SBS phase conjugator back through the ring in an equal but opposite direction for two passes, further reducing phase perturbations. A master oscillator inputs the beam through an isolation cell (Faraday or Pockels) which transmits the beam into the ring without polarization rotation. The isolation cell rotates polarization only in beams proceeding out of the ring to direct the beams out of the amplifier. The diffraction limited quality of the input beam is preserved in the amplifier so that a high power output beam having nearly the same diffraction limited quality is produced.

  4. The OPTHER Project: Progress toward the THz Amplifier

    DEFF Research Database (Denmark)

    Paoloni, C; Brunetti, F; Di Carlo, A;

    2011-01-01

    This paper describes the status of the OPTHER (OPtically driven TeraHertz AmplifiERs) project and progress toward the THz amplifier realization. This project represents a considerable advancement in the field of high frequency amplification. The design and realization of a THz amplifier within th...

  5. Design Of A Doherty Power Amplifier For GSM Systems

    Directory of Open Access Journals (Sweden)

    Saad Wasmi Osman

    2013-04-01

    Full Text Available This paper presents the design and analysis of Doherty power amplifier. The Doherty amplifier is used in  a base station for mobile system because of its high efficiency. The class AB power amplifier used in the configuration of the main and auxiliary amplifier. The result obtained shows that the Doherty power amplifier can be used on a wide band spectrum, the amplifier works at 900MHz and has very good power added efficiency (PAE and gain. The amplifier can also work at 1800MHz at input power greater than 20dBm. 

  6. The Electron Beam Semiconductor (EBS) amplifier

    Science.gov (United States)

    True, R. M.; Baxendale, J. F.

    1980-07-01

    The Electron Beam Semiconductor (EBS) concept has existed for three decades; but only within the last decade has an active, well-defined program been underway to develop devices that can operate as high-power radio frequency(RF) amplifiers, fast risetime switches, and current and voltage pulse amplifiers. This report discusses the test procedures, data and results of reliability testing of RF and video pulse EBS amplifiers at Electronics Research and Development Command (ERADCOM), Fort Monmouth, New Jersey. Also, the experimental analysis of the series connected diode EBS device is described in detail. Finally, the report concludes with a discussion of the state-of-the-art of EBS and future trends of the technology.

  7. Wideband pulse amplifiers for the NECTAr chip

    Energy Technology Data Exchange (ETDEWEB)

    Sanuy, A., E-mail: asanuy@ecm.ub.es [Dept. AM i Dept. ECM, Institut de Ciencies del Cosmos (ICC), Universitat de Barcelona. Marti i Franques 1, E08028, Barcelona (Spain); Delagnes, E. [IRFU/DSM/CEA, CE-Saclay, Bat. 141 SEN Saclay, F-91191, Gif-sur-Yvette (France); Gascon, D. [Dept. AM i Dept. ECM, Institut de Ciencies del Cosmos (ICC), Universitat de Barcelona. Marti i Franques 1, E08028, Barcelona (Spain); Sieiro, X. [Departament d' Electronica, Universitat de Barcelona. Marti i Franques 1, E08028, Barcelona (Spain); Bolmont, J.; Corona, P. [LPNHE, Universite Paris VI and Universite Paris VII and IN2P3/CNRS, Barre 12-22, 1er etage, 4 place Jussieu, 75252 Paris (France); Feinstein, F. [LUPM, Universite Montpellier II and IN2P3/CNRS, CC072, bat. 13, place Eugene Bataillon, 34095 Montpellier (France); Glicenstein, J-F. [IRFU/DSM/CEA, CE-Saclay, Bat. 141 SEN Saclay, F-91191, Gif-sur-Yvette (France); Naumann, C.L.; Nayman, P. [LPNHE, Universite Paris VI and Universite Paris VII and IN2P3/CNRS, Barre 12-22, 1er etage, 4 place Jussieu, 75252 Paris (France); Ribo, M. [Dept. AM i Dept. ECM, Institut de Ciencies del Cosmos (ICC), Universitat de Barcelona. Marti i Franques 1, E08028, Barcelona (Spain); and others

    2012-12-11

    The NECTAr collaboration's FE option for the camera of the CTA is a 16 bits and 1-3 GS/s sampling chip based on analog memories including most of the readout functions. This works describes the input amplifiers of the NECTAr ASIC. A fully differential wideband amplifier, with voltage gain up to 20 V/V and a BW of 400 MHz. As it is impossible to design a fully differential OpAmp with an 8 GHz GBW product in a 0.35 CMOS technology, an alternative implementation based on HF linearized transconductors is explored. The output buffer is a class AB miller operational amplifier, with special non-linear current boost.

  8. An automated test facility for neutronic amplifiers

    International Nuclear Information System (INIS)

    Neutronic amplifiers are used at the Chalk River Laboratory in applications such as neutron flux monitoring and reactor control systems. Routine preventive maintenance of control and safety systems included annual calibration and characterization of the neutronic amplifiers. An investigation into the traditional methods of annual routine maintenance of amplifiers concluded that frequency and phase response measurements in particular were labour intensive and subject to non-repeatable errors. A decision was made to upgrade testing methods and facilities by using programmable test equipment under the control of a computer. In order to verify the results of the routine measurements, expressions for the transfer functions were derived from the circuit diagrams. Frequency and phase responses were then calculated and plotted thus providing a bench-mark to which the test results can be compared. (author)

  9. Downstream processing of Isochrysis galbana: a step towards microalgal biorefinery

    NARCIS (Netherlands)

    Gilbert-López, B.; Mendiola, J.A.; Fontecha, J.; Broek, van den L.A.M.; Sijtsma, L.; Cifuentes, A.; Herrero, M.; Ibáñez, E.

    2015-01-01

    An algae-based biorefinery relies on the efficient use of algae biomass through its fractionation of several valuable/bioactive compounds that can be used in industry. If this biorefinery includes green platforms as downstream processing technologies able to fulfill the requirements of green chemist

  10. Modeling downstream fining in sand-bed rivers. II: Application

    Science.gov (United States)

    Wright, S.; Parker, G.

    2005-01-01

    In this paper the model presented in the companion paper, Wright and Parker (2005) is applied to a generic river reach typical of a large, sand-bed river flowing into the ocean in order to investigate the mechanisms controlling longitudinal profile development and downstream fining. Three mechanisms which drive downstream fining are studied: a delta prograding into standing water, sea-level rise, and tectonic subsidence. Various rates of sea-level rise (typical of the late Holocene) and tectonic subsidence are modeled in order to quantify their effects on the degree of profile concavity and downstream fining. Also, several other physical mechanisms which may affect fining are studied, including the relative importance of the suspended versus bed load, the effect of the loss of sediment overbank, and the influence of the delta bottom slope. Finally, sensitivity analysis is used to show that the grain-size distribution at the interface between the active layer and substrate has a significant effect on downstream fining. ?? 2005 International Association of Hydraulic Engineering and Research.

  11. Patents and Downstream Innovation Suppression - Facts or Fiction?

    DEFF Research Database (Denmark)

    Howells, John

    Merges and Nelson have proposed that pioneer patents have enabled their owners to 'block' or 'hold-up' downstream innovation in cases as important as the car, radio, aircraft and electric lighting (Merges and Nelson 1990, ; Merges and Nelson 1994). Merges and Nelson use their work to question...

  12. Peru's Downstream Natural Gas Sector : A Preliminary Assessment

    OpenAIRE

    Reinstein, David; Benítez, Daniel A. Benítez; Todd M. Johnson

    2011-01-01

    This study assesses the natural gas market in Peru. In the process of evaluating the downstream market, the study identifies opportunities for meeting the Government s aspirational goals with respect to energy and natural gas development, including the efficient use of natural gas in the power and other sectors, strengthening and coordinating national energy planning for the gas sector, in...

  13. Linear Amplifier Model for Optomechanical Systems

    CERN Document Server

    Botter, Thierry; Brahms, Nathan; Schreppler, Sydney; Stamper-Kurn, Dan M

    2011-01-01

    We model optomechanical systems as linear optical amplifiers. This provides a unified treatment of diverse optomechanical phenomena. We emphasize, in particular, the relationship between ponderomotive squeezing and optomechanically induced transparency, two foci of current research. We characterize the amplifier response to quantum and deliberately applied fluctuations, both optical and mechanical. Further, we apply these results to establish quantum limits on external force sensing both on and off cavity resonance. We find that the maximum sensitivity attained on resonance constitutes an absolute upper limit, not surpassed when detuning off cavity resonance. The theory can be extended to a two-sided cavity with losses and limited detection efficiency.

  14. Operational amplifier circuits analysis and design

    CERN Document Server

    Nelson, J C C

    1995-01-01

    This book, a revised and updated version of the author's Basic Operational Amplifiers (Butterworths 1986), enables the non-specialist to make effective use of readily available integrated circuit operational amplifiers for a range of applications, including instrumentation, signal generation and processing.It is assumed the reader has a background in the basic techniques of circuit analysis, particularly the use of j notation for reactive circuits, with a corresponding level of mathematical ability. The underlying theory is explained with sufficient but not excessive, detail. A range of compu

  15. Predistortion of a Bidirectional Cuk Audio Amplifier

    DEFF Research Database (Denmark)

    Birch, Thomas Hagen; Nielsen, Dennis; Knott, Arnold;

    2014-01-01

    Some non-linear amplifier topologies are capable of providing a larger voltage gain than one from a DC source, which could make them suitable for various applications. However, the non-linearities introduce a significant amount of harmonic distortion (THD). Some of this distortion could be reduced...... using predistortion. This paper suggests linearizing a nonlinear bidirectional Cuk audio amplifier using an analog predistortion approach. A prototype power stage was built and results show that a voltage gain of up to 9 dB and reduction in THD from 6% down to 3% was obtainable using this approach....

  16. Beyond nonlinear saturation of backward Raman amplifiers

    Science.gov (United States)

    Barth, Ido; Toroker, Zeev; Balakin, Alexey A.; Fisch, Nathaniel J.

    2016-06-01

    Backward Raman amplification is limited by relativistic nonlinear dephasing resulting in saturation of the leading spike of the amplified pulse. Pump detuning is employed to mitigate the relativistic phase mismatch and to overcome the associated saturation. The amplified pulse can then be reshaped into a monospike pulse with little precursory power ahead of it, with the maximum intensity increasing by a factor of two. This detuning can be employed advantageously both in regimes where the group velocity dispersion is unimportant and where the dispersion is important but small.

  17. Optimization of Pr3+:ZBLAN fiber amplifiers

    DEFF Research Database (Denmark)

    Pedersen, B.; Miniscalco, J. W.; Quimby, R. S.

    1992-01-01

    Experimental parameters have been measured and used in a quantitative model of Pr3+-doped fluorozirconate fiber amplifiers. The optimum cutoff wavelength was determined to be 800 nm and the gain for 400 mW of pump was found to increase from 12 to 34 dB if the NA was increased from 0.15 to 0.......25. Lengthening the metastable state lifetime from 110 to 300 μs would significantly improve amplifier performance while concentration quenching can appreciably degrade it...

  18. Methylation of Hg downstream from the Bonanza Hg mine, Oregon

    Science.gov (United States)

    Gray, John E.; Hines, Mark E.; Krabbenhoft, David P.; Thoms, Bryn

    2012-01-01

    Speciation of Hg and conversion to methyl-Hg were evaluated in stream sediment, stream water, and aquatic snails collected downstream from the Bonanza Hg mine, Oregon. Total production from the Bonanza mine was >1360t of Hg, during mining from the late 1800s to 1960, ranking it as an intermediate sized Hg mine on an international scale. The primary objective of this study was to evaluate the distribution, transport, and methylation of Hg downstream from a Hg mine in a coastal temperate climatic zone. Data shown here for methyl-Hg, a neurotoxin hazardous to humans, are the first reported for sediment and water from this area. Stream sediment collected from Foster Creek flowing downstream from the Bonanza mine contained elevated Hg concentrations that ranged from 590 to 71,000ng/g, all of which (except the most distal sample) exceeded the probable effect concentration (PEC) of 1060ng/g, the Hg concentration above which harmful effects are likely to be observed in sediment-dwelling organisms. Concentrations of methyl-Hg in stream sediment collected from Foster Creek varied from 11 to 62ng/g and were highly elevated compared to regional baseline concentrations (0.11-0.82ng/g) established in this study. Methyl-Hg concentrations in stream sediment collected in this study showed a significant correlation with total organic C (TOC, R2=0.62), generally indicating increased methyl-Hg formation with increasing TOC in sediment. Isotopic-tracer methods indicated that several samples of Foster Creek sediment exhibited high rates of Hg-methylation. Concentrations of Hg in water collected downstream from the mine varied from 17 to 270ng/L and were also elevated compared to baselines, but all were below the 770ng/L Hg standard recommended by the USEPA to protect against chronic effects to aquatic wildlife. Concentrations of methyl-Hg in the water collected from Foster Creek ranged from 0.17 to 1.8ng/L, which were elevated compared to regional baseline sites upstream and downstream

  19. Downstream-migrating fluvial point bars in the rock record

    Science.gov (United States)

    Ghinassi, Massimiliano; Ielpi, Alessandro; Aldinucci, Mauro; Fustic, Milovan

    2016-04-01

    Classical models developed for ancient fluvial point bars are based on the assumption that meander bends invariably increase their radius as meander-bend apices migrate in a direction transverse to the channel-belt axis (i.e., meander bend expansion). However, many modern meandering rivers are also characterized by down-valley migration of the bend apex, a mechanism that takes place without a significant change in meander radius and wavelength. Downstream-migrating fluvial point bars (DMFPB) are the dominant architectural element of these types of meander belts. Yet they are poorly known from ancient fluvial-channel belts, since their disambiguation from expansional point bars often requires fully-3D perspectives. This study aims to review DMFPB deposits spanning in age from Devonian to Holocene, and to discuss their main architectural and sedimentological features from published outcrop, borehole and 3D-seismic datasets. Fluvial successions hosting DMFPB mainly accumulated in low accommodation conditions, where channel belts were affected by different degrees of morphological (e.g., valleys) or tectonic (e.g., axial drainage of shortening basins) confinement. In confined settings, bends migrate downstream along the erosion-resistant valley flanks and little or no floodplain deposits are preserved. Progressive floor aggradation (e.g., valley filling) allow meander belts with DMFPB to decrease their degree of confinement. In less confined settings, meander bends migrate downstream mainly after impinging against older, erosion-resistant channel fill mud. By contrast, tectonic confinement is commonly associated with uplifted alluvial plains that prevented meander-bend expansion, in turn triggering downstream translation. At the scale of individual point bars, translational morphodynamics promote the preservation of downstream-bar deposits, whereas the coarser-grained upstream and central beds are less frequently preserved. However, enhanced preservation of upstream

  20. A novel virtual hub approach for multisource downstream service integration

    Science.gov (United States)

    Previtali, Mattia; Cuca, Branka; Barazzetti, Luigi

    2016-08-01

    A large development of downstream services is expected to be stimulated starting from earth observations (EO) datasets acquired by Copernicus satellites. An important challenge connected with the availability of downstream services is the possibility for their integration in order to create innovative applications with added values for users of different categories level. At the moment, the world of geo-information (GI) is extremely heterogeneous in terms of standards and formats used, thus preventing a facilitated access and integration of downstream services. Indeed, different users and data providers have also different requirements in terms of communication protocols and technology advancement. In recent years, many important programs and initiatives have tried to address this issue even on trans-regional and international level (e.g. INSPIRE Directive, GEOSS, Eye on Earth and SEIS). However, a lack of interoperability between systems and services still exists. In order to facilitate the interaction between different downstream services, a new architectural approach (developed within the European project ENERGIC OD) is proposed in this paper. The brokering-oriented architecture introduces a new mediation layer (the Virtual Hub) which works as an intermediary to bridge the gaps linked to interoperability issues. This intermediation layer de-couples the server and the client allowing a facilitated access to multiple downstream services and also Open Data provided by national and local SDIs. In particular, in this paper an application is presented integrating four services on the topic of agriculture: (i) the service given by Space4Agri (providing services based on MODIS and Landsat data); (ii) Gicarus Lab (providing sample services based on Landsat datasets) and (iii) FRESHMON (providing sample services for water quality) and services from a several regional SDIs.

  1. 76 FR 4896 - Call for Candidates

    Science.gov (United States)

    2011-01-27

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ACCOUNTING STANDARDS ADVISORY BOARD Call for Candidates AGENCY: Federal Accounting Standards Advisory Board. ACTION: Notice... Federal Accounting Standards Advisory Board (FASAB) is currently seeking candidates (candidates must...

  2. Feedback analysis of transimpedance operational amplifier circuits

    DEFF Research Database (Denmark)

    Bruun, Erik

    1993-01-01

    The transimpedance or current feedback operational amplifier (CFB op-amp) is reviewed and compared to a conventional voltage mode op-amp using an analysis emphasizing the basic feedback characteristics of the circuit. With this approach the paradox of the constant bandwidth obtained from CFB op...

  3. Ultra-low Voltage CMOS Cascode Amplifier

    DEFF Research Database (Denmark)

    Lehmann, Torsten; Cassia, Marco

    2000-01-01

    In this paper, we design a folded cascode operational transconductance amplifier in a standard CMOS process, which has a measured 69 dB DC gain, a 2 MHz bandwidth and compatible input- and output voltage levels at a 1 V power supply. This is done by a novel Current Driven Bulk (CDB) technique, wh...

  4. Stereoscopy Amplifies Emotions Elicited by Facial Expressions.

    Science.gov (United States)

    Hakala, Jussi; Kätsyri, Jari; Häkkinen, Jukka

    2015-12-01

    Mediated facial expressions do not elicit emotions as strongly as real-life facial expressions, possibly due to the low fidelity of pictorial presentations in typical mediation technologies. In the present study, we investigated the extent to which stereoscopy amplifies emotions elicited by images of neutral, angry, and happy facial expressions. The emotional self-reports of positive and negative valence (which were evaluated separately) and arousal of 40 participants were recorded. The magnitude of perceived depth in the stereoscopic images was manipulated by varying the camera base at 15, 40, 65, 90, and 115 mm. The analyses controlled for participants' gender, gender match, emotional empathy, and trait alexithymia. The results indicated that stereoscopy significantly amplified the negative valence and arousal elicited by angry expressions at the most natural (65 mm) camera base, whereas stereoscopy amplified the positive valence elicited by happy expressions in both the narrowed and most natural (15-65 mm) base conditions. Overall, the results indicate that stereoscopy amplifies the emotions elicited by mediated emotional facial expressions when the depth geometry is close to natural. The findings highlight the sensitivity of the visual system to depth and its effect on emotions. PMID:27551358

  5. Nucleic acids from long-term preserved FFPE tissues are suitable for downstream analyses.

    Science.gov (United States)

    Ludyga, Natalie; Grünwald, Barbara; Azimzadeh, Omid; Englert, Sonja; Höfler, Heinz; Tapio, Soile; Aubele, Michaela

    2012-02-01

    Tissues used for clinical diagnostics are mostly formalin-fixed and paraffin-embedded (FFPE) which provides many advantages. However, the quality of the obtained nucleic acids (NA) is reduced and this turns out to be a challenge for further molecular analyses. Although the spectrum of analyses of NA extracted from FFPE tissue has increased, the standard operating procedures for NA isolation from old tissue blocks still need to be improved. Here, we compared the efficiency of different NA extraction methods, using FFPE tissues of variable age and origin, with respect to downstream analyses. Our study showed that the phenol-chloroform isoamyl alcohol (PCI) and the commercial Qiagen protocol yielded samples with highest purity. The PCI protocol delivered the longest amplicons even from samples from the 1970s. We developed a short (1 h) tissue lysis procedure that turned out to be highly time- and cost-effective when DNA quality was tested using single and multiplex PCR. Compared to a 1-day lysis-protocol, the amplicons were only 100 bp shorter. In addition, single-copy genes used in daily routine were successfully amplified from long-term stored FFPE samples following 1-h tissue-lysis. The RNA integrity numbers (RIN) determined on RNA isolated from FFPE tissues indicated degraded RNA; however, all RINs were above the generally agreed threshold of 1.4. We showed that, depending on the purpose of the analysis, NA retrieved from FFPE tissues older than 40 years may be successfully used for molecular analysis.

  6. Tunable microstrip SQUID amplifiers for the Gen 2 Axion Dark Matter eXperiment (ADMX)

    Science.gov (United States)

    O'Kelley, Sean; Hilton, Gene; Clarke, John

    We present a series of tunable microstrip SQUID amplifiers (MSAs) for installation in ADMX. The axion dark matter candidate is detected via Primakoff conversion to a microwave photon in a high-Q (~100,000) tunable microwave cavity cooled with a dilution refrigerator in the presence of a 7-tesla magnetic field. The microwave photon frequency ν is a function of the unknown axion mass, so both the cavity and amplifier must be scanned over a wide frequency range. An MSA is a linear, phase-preserving amplifier consisting of a superconducting, resonant microstrip flux-coupled to a resistively-shunted dc SQUID biased into the voltage state. Tunability is achieved by terminating the microstrip with low inductance GaAs varactor diodes that operate below 100 mK. By varying the bias voltage of the varactors we vary their capacitance, allowing a reflected phase varying from nearly 0 to π, thus achieving a tunability close to a factor of 2. We demonstrate several devices operating below 100 mK, matched to the discrete operating bands of ADMX at frequencies ranging from 560 MHz to 1 GHz, that exhibit gains exceeding 20 dB. The associated noise temperatures, measured with a hot/cold load, approach the standard quantum limit (hν/kB) for a linear phase-preserving amplifier.

  7. Upstream-downstream cooperation approach in Guanting Reservoir watershed

    Institute of Scientific and Technical Information of China (English)

    YANG Zhi-feng; ZHANG Wen-guo

    2005-01-01

    A case study is introduced and discussed concerning water dispute of misuse and pollution between up- and down-stream parts.The relations between water usage and local industrial structures are analyzed. Results show it is important to change industrial structures of the target region along with controlling water pollution by technical and engineering methods. Three manners of upstream-downstream cooperation are presented and discussed based on the actual conditions of Guangting Reservoir watershed, Two typical scenarios are supposed and studied along with the local plan on water resources development. The best solution for this cooperation presents a good way to help the upstream developing in a new pattern of eco-economy.

  8. Innovation Incentive of Downstream Firms in Stackelberg Duopoly Model

    Institute of Scientific and Technical Information of China (English)

    Guo Hongzhen; Yan Qingyou; Huang Wenjie

    2006-01-01

    The licensing strategies and innovation incentives of downstream firms in a Stackelberg duopoly model were analyzed under three respective assumptions that upstream industry is monopoly, duopoly, or perfect competition. It is found that the Stackelberg firm may license his drastic innovation by a fixed royalty rate which is lower than innovation size. The incentives of drastic innovation of Stackelberg firm facing input suppliers with market power decrease considerably even under royalty licensing,compared with facing perfectly competitive input market.

  9. Collusion and downstream entry in a vertically integrated industry

    OpenAIRE

    Éric Avenel; Stéphane Caprice

    2012-01-01

    We analyse the impact of an entry threat at the downstream level on the ability of a pair of vertically integrated incumbents to collude. We present an original model of horizontal product differentiation on the final market and characterize the structures of this market for which an entry threat facilitates collusion between incumbents. While the entry threat leaves collusion and deviation profits unchanged, it lowers profits in punishment periods. Consequently, an entry threat discourages d...

  10. Corner waves downstream from a partially submerged vertical plate

    OpenAIRE

    Martínez-Legazpi Aguiló, Pablo

    2011-01-01

    In this dissertation, the high-Reynolds-number flow near the corner of a vertical at plate partially submerged across an uniform stream has been studied using a combination of experimental, numerical and analytical tools. In this configuration, a three dimensional wave forms at the corner of the plate which evolves downstream in a similar way as a time-evolving two dimensional plunging or spilling breaker, depending the occurrence of one or the other type of breaker on the flow conditions. Ex...

  11. Microalgae downstream processing and economical approaches of biodiesel producton processes

    OpenAIRE

    Ríos, Sergio Daniel

    2013-01-01

    Microalgae oil has been identified as a reliable resource for biodiesel production due to its high lipid productivity and potential cultivation in non-fertile locations. However, high scale production of microalgae based biodiesel depends on the optimization of the entire process to be economically feasible. The present work combine the optimization of microalgae downstream processes with computational tools for the modeling of different scenarios of the harvesting, oil extraction and transes...

  12. Amplified spontaneous emission spectrum and gain characteristic of a two-electrode semiconductor optical amplifier*

    Institute of Scientific and Technical Information of China (English)

    Wang Hanchao; Huang Lirong; Shi Zhongwei

    2011-01-01

    A two-electrode multi-quantum-well semiconductor optical amplifier is designed and fabricated. The amplified spontaneous emission (ASE) spectrum and gain were measured and analyzed. It is shown that the ASE spectrum and gain characteristic are greatly influenced by the distribution of the injection current density. By changing the injection current density of two electrodes, the full width at half maximum, peak wavelength, peak power of the ASE spectrum and the gain characteristic can be easily controlled.

  13. Empathy Development in Teacher Candidates

    Science.gov (United States)

    Boyer, Wanda

    2010-01-01

    Using a grounded theory research design, the author examined 180 reflective essays of teacher candidates who participated in a "Learning Process Project," in which they were asked to synthesize and document their discoveries about the learning process over the course of a completely new learning experience as naive learners. This study explored…

  14. Candidate gene prioritization with Endeavour.

    Science.gov (United States)

    Tranchevent, Léon-Charles; Ardeshirdavani, Amin; ElShal, Sarah; Alcaide, Daniel; Aerts, Jan; Auboeuf, Didier; Moreau, Yves

    2016-07-01

    Genomic studies and high-throughput experiments often produce large lists of candidate genes among which only a small fraction are truly relevant to the disease, phenotype or biological process of interest. Gene prioritization tackles this problem by ranking candidate genes by profiling candidates across multiple genomic data sources and integrating this heterogeneous information into a global ranking. We describe an extended version of our gene prioritization method, Endeavour, now available for six species and integrating 75 data sources. The performance (Area Under the Curve) of Endeavour on cross-validation benchmarks using 'gold standard' gene sets varies from 88% (for human phenotypes) to 95% (for worm gene function). In addition, we have also validated our approach using a time-stamped benchmark derived from the Human Phenotype Ontology, which provides a setting close to prospective validation. With this benchmark, using 3854 novel gene-phenotype associations, we observe a performance of 82%. Altogether, our results indicate that this extended version of Endeavour efficiently prioritizes candidate genes. The Endeavour web server is freely available at https://endeavour.esat.kuleuven.be/. PMID:27131783

  15. Candidate Prediction Models and Methods

    DEFF Research Database (Denmark)

    Nielsen, Henrik Aalborg; Nielsen, Torben Skov; Madsen, Henrik;

    2005-01-01

    This document lists candidate prediction models for Work Package 3 (WP3) of the PSO-project called ``Intelligent wind power prediction systems'' (FU4101). The main focus is on the models transforming numerical weather predictions into predictions of power production. The document also outlines the...

  16. Candidate cave entrances on Mars

    Science.gov (United States)

    Cushing, Glen E.

    2012-01-01

    This paper presents newly discovered candidate cave entrances into Martian near-surface lava tubes, volcano-tectonic fracture systems, and pit craters and describes their characteristics and exploration possibilities. These candidates are all collapse features that occur either intermittently along laterally continuous trench-like depressions or in the floors of sheer-walled atypical pit craters. As viewed from orbit, locations of most candidates are visibly consistent with known terrestrial features such as tube-fed lava flows, volcano-tectonic fractures, and pit craters, each of which forms by mechanisms that can produce caves. Although we cannot determine subsurface extents of the Martian features discussed here, some may continue unimpeded for many kilometers if terrestrial examples are indeed analogous. The features presented here were identified in images acquired by the Mars Odyssey's Thermal Emission Imaging System visible-wavelength camera, and by the Mars Reconnaissance Orbiter's Context Camera. Select candidates have since been targeted by the High-Resolution Imaging Science Experiment. Martian caves are promising potential sites for future human habitation and astrobiology investigations; understanding their characteristics is critical for long-term mission planning and for developing the necessary exploration technologies.

  17. The impacts of wind power integration on sub-daily variation in river flows downstream of hydroelectric dams.

    Science.gov (United States)

    Kern, Jordan D; Patino-Echeverri, Dalia; Characklis, Gregory W

    2014-08-19

    Due to their operational flexibility, hydroelectric dams are ideal candidates to compensate for the intermittency and unpredictability of wind energy production. However, more coordinated use of wind and hydropower resources may exacerbate the impacts dams have on downstream environmental flows, that is, the timing and magnitude of water flows needed to sustain river ecosystems. In this paper, we examine the effects of increased (i.e., 5%, 15%, and 25%) wind market penetration on prices for electricity and reserves, and assess the potential for altered price dynamics to disrupt reservoir release schedules at a hydroelectric dam and cause more variable and unpredictable hourly flow patterns (measured in terms of the Richards-Baker Flashiness (RBF) index). Results show that the greatest potential for wind energy to impact downstream flows occurs at high (∼25%) wind market penetration, when the dam sells more reserves in order to exploit spikes in real-time electricity prices caused by negative wind forecast errors. Nonetheless, compared to the initial impacts of dam construction (and the dam's subsequent operation as a peaking resource under baseline conditions) the marginal effects of any increased wind market penetration on downstream flows are found to be relatively minor.

  18. The impacts of wind power integration on sub-daily variation in river flows downstream of hydroelectric dams.

    Science.gov (United States)

    Kern, Jordan D; Patino-Echeverri, Dalia; Characklis, Gregory W

    2014-08-19

    Due to their operational flexibility, hydroelectric dams are ideal candidates to compensate for the intermittency and unpredictability of wind energy production. However, more coordinated use of wind and hydropower resources may exacerbate the impacts dams have on downstream environmental flows, that is, the timing and magnitude of water flows needed to sustain river ecosystems. In this paper, we examine the effects of increased (i.e., 5%, 15%, and 25%) wind market penetration on prices for electricity and reserves, and assess the potential for altered price dynamics to disrupt reservoir release schedules at a hydroelectric dam and cause more variable and unpredictable hourly flow patterns (measured in terms of the Richards-Baker Flashiness (RBF) index). Results show that the greatest potential for wind energy to impact downstream flows occurs at high (∼25%) wind market penetration, when the dam sells more reserves in order to exploit spikes in real-time electricity prices caused by negative wind forecast errors. Nonetheless, compared to the initial impacts of dam construction (and the dam's subsequent operation as a peaking resource under baseline conditions) the marginal effects of any increased wind market penetration on downstream flows are found to be relatively minor. PMID:25061693

  19. Comparative analysis of four methods to extract DNA from paraffin-embedded tissues: effect on downstream molecular applications

    Directory of Open Access Journals (Sweden)

    Savelkoul Paul HM

    2010-09-01

    Full Text Available Abstract Background A large portion of tissues stored worldwide for diagnostic purposes is formalin-fixed and paraffin-embedded (FFPE. These FFPE-archived tissues are an extremely valuable source for retrospective (genetic studies. These include mutation screening in cancer-critical genes as well as pathogen detection. In this study we evaluated the impact of several widely used DNA extraction methods on the quality of molecular diagnostics on FFPE tissues. Findings We compared 4 DNA extraction methods from 4 identically processed FFPE mammary-, prostate-, colon- and lung tissues with regard to PCR inhibition, real time SNP detection and amplifiable fragment size. The extraction methods, with and without proteinase K pre-treatment, tested were: 1 heat-treatment, 2 QIAamp DNA-blood-mini-kit, 3 EasyMAG NucliSens and 4 Gentra Capture-Column-kit. Amplifiable DNA fragment size was assessed by multiplexed 200-400-600 bp PCR and appeared highly influenced by the extraction method used. Proteinase K pre-treatment was a prerequisite for proper purification of DNA from FFPE. Extractions with QIAamp, EasyMAG and heat-treatment were found suitable for amplification of fragments up to 400 bp from all tissues, 600 bp amplification was marginally successful (best was QIAamp. QIAamp and EasyMAG extracts were found suitable for downstream real time SNP detection. Gentra extraction was unsuitable. Hands-on time was lowest for heat-treatment, followed by EasyMAG. Conclusions We conclude that the extraction method plays an important role with regard to performance in downstream molecular applications.

  20. First lasing of the regenerative amplifier FEL

    International Nuclear Information System (INIS)

    The regenerative amplifier free-electron laser (RAFEL) is a high-gain RF-linac FEL capable of producing high optical power from a compact design. The combination of a high-gain and small optical feedback enables the FEL to reach saturation and produce a high optical power and high extraction efficiency without the risk of optical damage to the mirrors. This paper summarizes the first lasing of the regenerative amplifier FEL and describes recent experimental results. The highest optical energy achieved thus far at 16.3 μm is 1.7 J over a train of 900 micropulses. We infer pulse energy of 1.9 mJ in each 16 ps micropulse, corresponding to a peak power of 120 MW

  1. Behavioral modeling of Digitally Adjustable Current Amplifier

    Directory of Open Access Journals (Sweden)

    Josef Polak

    2015-03-01

    Full Text Available This article presents the digitally adjustable current amplifier (DACA and its analog behavioral model (ABM, which is suitable for both ideal and advanced analyses of the function block using DACA as active element. There are four levels of this model, each being suitable for simulation of a certain degree of electronic circuits design (e.g. filters, oscillators, generators. Each model is presented through a schematic wiring in the simulation program OrCAD, including a description of equations representing specific functions in the given level of the simulation model. The design of individual levels is always verified using PSpice simulations. The ABM model has been developed based on practically measured values of a number of DACA amplifier samples. The simulation results for proposed levels of the ABM model are shown and compared with the results of the real easurements of the active element DACA.

  2. High power single-frequency Innoslab amplifier.

    Science.gov (United States)

    Han, Ke-Zhen; Ning, Jian; Zhang, Bai-Tao; Wang, Yi-Ran; Zhang, Hai-Kun; Nie, Hong-Kun; Sun, Xiao-Li; He, Jing-Liang

    2016-07-10

    A laser diode array (LDA) end-pumped continuous-wave single-frequency Innoslab amplifier has been demonstrated. The Gaussian ray bundle method was used to model the light propagation in the Innoslab amplifier for the first time to the best of our knowledge. With discrete reflectors, the maximum output of 60 W with a linewidth of 44 MHz was achieved under the pump power of 245 W, corresponding to the optical-optical efficiency of 24.5%. The beam quality factor M2 at the output power of 51 W in the horizontal and vertical direction was measured to be 1.4 and 1.3, respectively. The long-term power instability in 2 h was less than 0.25%. PMID:27409308

  3. Fundamentals of fiber lasers and fiber amplifiers

    CERN Document Server

    Ter-Mikirtychev, Valerii (Vartan)

    2014-01-01

    This book covers the fundamental aspects of fiber lasers and fiber amplifiers, and includes a wide range of material from laser physics fundamentals to state-of-the-art topics in this rapidly growing field of quantum electronics. Emphasis is placed on the nonlinear processes taking place in fiber lasers and amplifiers, their similarities, differences to, and their advantages over other solid-state lasers. The reader will learn basic principles of solid-state physics and optical spectroscopy of laser active centers in fibers, main operational laser regimes, and practical recommendations and suggestions on fiber laser research, laser applications, and laser product development. The book will be useful for students, researchers, and professionals who work with lasers, in the optical communications, chemical and biological industries, etc.

  4. Linear control of oscillator and amplifier flows*

    Science.gov (United States)

    Schmid, Peter J.; Sipp, Denis

    2016-08-01

    Linear control applied to fluid systems near an equilibrium point has important applications for many flows of industrial or fundamental interest. In this article we give an exposition of tools and approaches for the design of control strategies for globally stable or unstable flows. For unstable oscillator flows a feedback configuration and a model-based approach is proposed, while for stable noise-amplifier flows a feedforward setup and an approach based on system identification is advocated. Model reduction and robustness issues are addressed for the oscillator case; statistical learning techniques are emphasized for the amplifier case. Effective suppression of global and convective instabilities could be demonstrated for either case, even though the system-identification approach results in a superior robustness to off-design conditions.

  5. Design of an 1800 nm Raman Amplifier

    DEFF Research Database (Denmark)

    Svane, Ask Sebastian; Rottwitt, Karsten

    Different approaches are being explored to increase the capacity of communication systems [1,2], both long and short range systems. One approach is by exploiting new optical wavelength bands, outside the conventional communication window from 1530 nm to 1625 nm. Hollow core fibers have been...... in the pump power requirement and deteriorated noise properties. Here we demonstrate a Raman amplifier designed for signal wavelengths around 1800 nm. The amplification fiber is an OFS PM Raman fiber, and is pumped by a Raman fiber laser emitting at 1680 nm [4]. The amplifier was pumped co......-polarized and backward, with respect to the singal. In Fig. 2 a measured Raman on/off gain exceeding 9 dB for 285 mW of injected pump power is obtained in a 4.35 km long fiber. A broadband supercontinuum source was used as a signal from 1700 nm to 1900 nm....

  6. Noise Gain Features of Fiber Raman Amplifier

    Directory of Open Access Journals (Sweden)

    Georgii S. Felinskyi

    2016-01-01

    Full Text Available The formation dynamics of the optical noise in a silica single mode fiber (SMF as function of the pump power variation in the counter pumped fiber Raman amplifier (FRA is experimentally studied. The ratio between the power of amplified spontaneous emission and the power of incoherent optical noise is quantitatively determined by detailed analysis of experimental data in the pump powers range of 100–300 mW within the full band of Stokes frequencies, including FRA working wavelengths over the C + L transparency windows. It is found out the maximum of Raman gain coefficient for optical noise does not exceed ~60% of corresponding peak at the gain profile maximum of coherent signal. It is shown that the real FRA noise figure may be considerably less than 3 dB over a wide wavelength range (100 nm at a pump power of several hundreds of mW.

  7. Cryogenic cooling for high power laser amplifiers

    Directory of Open Access Journals (Sweden)

    Perin J.P.

    2013-11-01

    Full Text Available Using DPSSL (Diode Pumped Solid State Lasers as pumping technology, PW-class lasers with enhanced repetition rates are developed. Each of the Yb YAG amplifiers will be diode-pumped at a wavelength of 940 nm. This is a prerequisite for achieving high repetition rates (light amplification duration 1 millisecond and repetition rate 10 Hz. The efficiency of DPSSL is inversely proportional to the temperature, for this reason the slab amplifier have to be cooled at a temperature in the range of 100 K–170 K with a heat flux of 1 MW*m−2. This paper describes the thermo-mechanical analysis for the design of the amplification laser head, presents a preliminary proposal for the required cryogenic cooling system and finally outlines the gain of cryogenic operation for the efficiency of high pulsed laser.

  8. Amplifying the Hawking Signal in BECs

    Directory of Open Access Journals (Sweden)

    Roberto Balbinot

    2014-01-01

    Full Text Available We consider simple models of Bose-Einstein condensates to study analog pair-creation effects, namely, the Hawking effect from acoustic black holes and the dynamical Casimir effect in rapidly time-dependent backgrounds. We also focus on a proposal by Cornell to amplify the Hawking signal in density-density correlators by reducing the atoms’ interactions shortly before measurements are made.

  9. Electrically Pumped Vertical-Cavity Amplifiers

    DEFF Research Database (Denmark)

    Greibe, Tine

    2007-01-01

    In this work, the design of electrically pumped vertical cavity semiconductor optical amplifiers (eVCAs) for use in a mode-locked external-cavity laser has been developed, investigated and analysed. Four different eVCAs, one top-emitting and three bottom emitting structures, have been designed...... and discussed. The thesis concludes with recommendations for further work towards the realisation of compact electrically pumped mode-locked vertical externalcavity surface emitting lasers....

  10. Quantum noise in ideal operational amplifiers

    OpenAIRE

    Courty, Jean-Michel; Grassia, Francesca; Reynaud, Serge

    1998-01-01

    We consider a model of quantum measurement built on an ideal operational amplifier operating in the limit of infinite gain, infinite input impedance and null output impedance and with a feddback loop. We evaluate the intensity and voltage noises which have to be added to the classical amplification equations in order to fulfill the requirements of quantum mechanics. We give a description of this measurement device as a quantum network scattering quantum fluctuations from input to output ports.

  11. Charge sensitive amplifies. The state of arts

    Energy Technology Data Exchange (ETDEWEB)

    Mori, Kunishiro [Clear Pulse Co., Tokyo (Japan)

    1996-07-01

    In the radiation detectors, signals are essentially brought with charges produced by radiation, then it is naturally the best way to use a charge sensitive amplifier (CSA) system to extract those signals. The CSA is thought to be the best amplifier suitable to almost all the radiation detectors, if neglecting economical points of view. The CSA has been only applied to special fields like radiation detection because the concept of `charges` is not so universal against the concepts of `voltage` and `current`. The CSA, however, is low in noise and a high speed amplifier and may be applicable not only to radiation measurement but also piezoelectric devices and also bolometers. In this article, noise in the CSA, basic circuit on the CSA, concepts of `equivalent noise charge` (ENC), a method for the ENC, and importance of the `open-loop gain` in the CSA to achieve better performance of it and how to realize in a practical CSA were described. And, characteristics on a counting rate of the CSA, various circuit used in the CSA, and CSAs which are commercially available at present and special purpose CSAs were also introduced. (G.K.)

  12. Microstrip SQUID amplifiers for quantum information science

    Science.gov (United States)

    Defeo, M. P.; Plourde, B. L. T.

    2012-02-01

    Recent progress in SQUID amplifiers suggests that these devices might approach quantum-limited sensitivity in the microwave range, thus making them a viable option for measurement of superconducting quantum systems. In the microstrip SQUID amplifier configuration, gains of around 20dB are possible at frequencies of several hundred MHz, and the gain is limited by the maximum voltage modulation available from the SQUID. One route for increasing the voltage modulation involves using larger resistive shunts, however maintaining non-hysteretic device operation requires smaller junction capacitances than is possible with conventional photolithographically patterned junctions. Operating at higher frequencies requires a shorter input coil which reduces mutual inductance between the coil and washer and therefore gain. We have fabricated microstrip SQUID amplifiers using submicron Al-AlOx-Al junctions and large shunts. The input coil and SQUID washer are optimized for producing high gain at frequencies in the gigahertz range. Recent measurements of gain and noise temperature will be discussed as well as demonstrations of these devices as a first stage of amplification for a superconducting system

  13. The development of DUV chemically amplified resists

    Energy Technology Data Exchange (ETDEWEB)

    Thackeray, J.W.; Fedynyshyn, T.H.; Small, R.D. [Shipley Co. Inc., Marlboro, MA (United States)

    1993-12-31

    The development of deep ultraviolet (DUV) resists has necessitated the introduction of new concepts in resist materials and chemistry. Successful DUV resist systems now employ the concept of chemical amplification. This catalytic reaction leads to a substantial enhancement in the imaging dose. Another benefit of chemical amplified resists is that they allow the design of materials which can be transparent to DUV exposure wavelengths, yet they can still have high sensitivity. Commercial and prototype positive- and negative-tone resists are now readily available and these resists have been used in pilot production to make the most advanced integrated circuits with {le}0.35 {mu}m design rules. At Shipley, we have undertaken to develop both negative- and positive-tone chemically amplified resists for DUV lithography. These resists are capable of high resolution (0.3 {mu}m), fast photospeed ({le}30 mJ/sq. cm), and excellent etch resistance. This presentation will discuss the chemical and lithographic properties of the Shipley negative- and positive-tone DUV chemically amplified resists. General discussion of the importance of activation energy for the catalytic process, catalytic chain length, and environmental stability will be given.

  14. Parallel reservoir computing using optical amplifiers.

    Science.gov (United States)

    Vandoorne, Kristof; Dambre, Joni; Verstraeten, David; Schrauwen, Benjamin; Bienstman, Peter

    2011-09-01

    Reservoir computing (RC), a computational paradigm inspired on neural systems, has become increasingly popular in recent years for solving a variety of complex recognition and classification problems. Thus far, most implementations have been software-based, limiting their speed and power efficiency. Integrated photonics offers the potential for a fast, power efficient and massively parallel hardware implementation. We have previously proposed a network of coupled semiconductor optical amplifiers as an interesting test case for such a hardware implementation. In this paper, we investigate the important design parameters and the consequences of process variations through simulations. We use an isolated word recognition task with babble noise to evaluate the performance of the photonic reservoirs with respect to traditional software reservoir implementations, which are based on leaky hyperbolic tangent functions. Our results show that the use of coherent light in a well-tuned reservoir architecture offers significant performance benefits. The most important design parameters are the delay and the phase shift in the system's physical connections. With optimized values for these parameters, coherent semiconductor optical amplifier (SOA) reservoirs can achieve better results than traditional simulated reservoirs. We also show that process variations hardly degrade the performance, but amplifier noise can be detrimental. This effect must therefore be taken into account when designing SOA-based RC implementations.

  15. Application module of universal amplifier in education process

    OpenAIRE

    CHALOUPEK, Pavel

    2013-01-01

    This thesis deals with the teaching and implementation module for teaching in secondary schools and their role in education. Following the theory being discussed in relation to a valid educational program. Learning amplifier module implemented by the assignment to DPS. The activity of the amplifier module to simulate in Multisim simulation program. Next is made circuitry design in discrete amplifier module. There evaluated the feasibility and simulation of realizations amplifier module in sec...

  16. Noise and saturation properties of semiconductor quantum dot optical amplifiers

    DEFF Research Database (Denmark)

    Berg, Tommy Winther; Mørk, Jesper

    2002-01-01

    We present a detailed theoretical analysis of quantum dot optical amplifiers. Due to the presence of a reservoir of wetting layer states, the saturation and noise properties differ markedly from bulk or QW amplifiers and may be significantly improved.......We present a detailed theoretical analysis of quantum dot optical amplifiers. Due to the presence of a reservoir of wetting layer states, the saturation and noise properties differ markedly from bulk or QW amplifiers and may be significantly improved....

  17. Efficiency of low power audio amplifiers and loudspeakers

    OpenAIRE

    Burrow, SG; Grant, Duncan A

    2001-01-01

    In this paper we look at the load presented to audio amplifiers by real transducers. We consider the power losses in Class-AB and Class-D amplifier topologies, and determine that in order to predict efficiency it is necessary to consider the amplifier/transducer combination. The ability of the class-D amplifier to recycle quadrature load current offers new ways to improve efficiency.

  18. Lung-Derived Mediators Induce Cytokine Production in Downstream Organs via an NF-κB-Dependent Mechanism

    Directory of Open Access Journals (Sweden)

    E. K. Patterson

    2013-01-01

    Full Text Available In the setting of acute lung injury, levels of circulating inflammatory mediators have been correlated with adverse outcomes. Previous studies have demonstrated that injured, mechanically ventilated lungs represent the origin of the host inflammatory response; however, mechanisms which perpetuate systemic inflammation remain uncharacterized. We hypothesized that lung-derived mediators generated by mechanical ventilation (MV are amplified by peripheral organs in a “feed forward” mechanism of systemic inflammation. Herein, lung-derived mediators were collected from 129X1/SVJ mice after 2 hours of MV while connected to the isolated perfused mouse lung model setup. Exposure of liver endothelial cells to lung-derived mediators resulted in a significant increase in G-CSF, IL-6, CXCL-1, CXCL-2, and MCP-1 production compared to noncirculated control perfusate media (P<0.05. Furthermore, inhibition of the NF-κB pathway significantly mitigated this response. Changes in gene transcription were confirmed using qPCR for IL-6, CXCL-1, and CXCL-2. Additionally, liver tissue obtained from mice subjected to 2 hours of in vivo MV demonstrated significant increases in hepatic gene transcription of IL-6, CXCL-1, and CXCL-2 compared to nonventilated controls. Collectively, this data demonstrates that lung-derived mediators, generated in the setting of MV, are amplified by downstream organs in a feed forward mechanism of systemic inflammation.

  19. Evolutionary divergence of the plant elicitor peptides (Peps) and their receptors: interfamily incompatibility of perception but compatibility of downstream signalling.

    Science.gov (United States)

    Lori, Martina; van Verk, Marcel C; Hander, Tim; Schatowitz, Hendrik; Klauser, Dominik; Flury, Pascale; Gehring, Christoph A; Boller, Thomas; Bartels, Sebastian

    2015-08-01

    Plant elicitor peptides (Peps) are potent inducers of pattern-triggered immunity and amplify the immune response against diverse pathogens. Peps have been discovered and studied extensively in Arabidopsis and only recently orthologues in maize were also identified and characterized in more detail.Here, the presence of PROPEPs, the Pep precursors, and PEPRs, the Pep receptors, was investigated within the plant kingdom. PROPEPs and PEPRs were identified in most sequenced species of the angiosperms. The conservation and compatibility of the Pep-PEPR-system was analysed by using plants of two distantly related dicot families, Brassicaceae and Solanaceae, and a representative family of monocot plants, the Poaceae. All three plant families contain important crop plants, including maize, rice, tomato, potato, and canola. Peps were not recognized by species outside of their plant family of origin, apparently because of a divergence of the Pep sequences. Three family-specific Pep motifs were defined and the integration of such a motif into the Pep sequence of an unrelated Pep enabled its perception. Transient transformation of Nicotiana benthamiana with the coding sequences of the AtPEPR1 and ZmPEPR1a led to the recognition of Pep peptides of Brassicaceae or Poaceae origin, respectively, and to the proper activation of downstream signalling. It was concluded that signalling machinery downstream of the PEPRs is highly conserved whereas the leucine-rich repeat domains of the PEPRs co-evolved with the Peps, leading to distinct motifs and, with it, interfamily incompatibility. PMID:26002971

  20. Evolutionary divergence of the plant elicitor peptides (Peps) and their receptors: interfamily incompatibility of perception but compatibility of downstream signalling

    KAUST Repository

    Lori, M.

    2015-05-22

    Plant elicitor peptides (Peps) are potent inducers of pattern-triggered immunity and amplify the immune response against diverse pathogens. Peps have been discovered and studied extensively in Arabidopsis and only recently orthologs in maize were also identified and characterized in more detail. Here, the presence of PROPEPs, the Pep precursors, and PEPRs, the Pep receptors, was investigated within the plant kingdom. PROPEPs and PEPRs were identified in most sequenced species of the angiosperms. The conservation and compatibility of the Pep-PEPR-system was analysed by using plants of two distantly related dicot families, Brassicaceae and Solanaceae, and a representative family of monocot plants, the Poaceae. All three plant families contain important crop plants, including maize, rice, tomato, potato, and canola. Peps were not recognized by species outside of their plant family of origin, apparently because of a divergence of the Pep sequences. Three family-specific Pep motifs were defined and the integration of such a motif into the Pep sequence of an unrelated Pep enabled its perception. Transient transformation of Nicotiana benthamiana with the coding sequences of the AtPEPR1 and ZmPEPR1a led to the recognition of Pep peptides of Brassicaceae or Poaceae origin, respectively, and to the proper activation of downstream signalling. It was concluded that signalling machinery downstream of the PEPRs is highly conserved whereas the leucine-rich repeat domains of the PEPRs co-evolved with the Peps, leading to distinct motifs and, with it, interfamily incompatibility.

  1. Matched wideband low-noise amplifiers for radio astronomy.

    Science.gov (United States)

    Weinreb, S; Bardin, J; Mani, H; Jones, G

    2009-04-01

    Two packaged low noise amplifiers for the 0.3-4 GHz frequency range are described. The amplifiers can be operated at temperatures of 300-4 K and achieve noise temperatures in the 5 K range (radio astronomy systems or as i.f. amplifiers following superconducting mixers operating in the millimeter and submillimeter frequency range. PMID:19405681

  2. Digital system provides superregulation of nanosecond amplifier-discriminator circuit

    Science.gov (United States)

    Forges, K. G.

    1966-01-01

    Feedback system employing a digital logic comparator to detect and correct amplifier drift provides stable gain characteristics for nanosecond amplifiers used in counting applications. Additional anticoincidence logic enables application of the regulation circuit to the amplifier and discriminator while they are mounted in an operable circuit.

  3. The Dynamics of Semiconductor Optical Amplifiers – Modeling and Applications

    DEFF Research Database (Denmark)

    Mørk, Jesper; Nielsen, Mads Lønstrup; Berg, Tommy Winther

    2003-01-01

    The importance of semiconductor optical amplifiers is discussed. A semiconductor optical amplifier (SOA) is a semiconductor laser with anti-reflection coated facets that amplifies an injected light signal by means of stimulated emission. SOAs have a number of unique properties that open up...

  4. Fiber optical parametric amplifiers in optical communication systems

    DEFF Research Database (Denmark)

    Marhic, Michel E.; Andrekson, Peter A.; Petropoulos, Periklis;

    2015-01-01

    The prospects for using fiber optical parametric amplifiers (OPAs) in optical communication systems are reviewed. Phase-insensitive amplifiers (PIAs) and phase-sensitive amplifiers (PSAs) are considered. Low-penalty amplification at/or near 1 Tb/s has been achieved, for both wavelength- and time...

  5. Polarization of Tapered Semiconductor Travelling-Wave Amplifiers

    Institute of Scientific and Technical Information of China (English)

    焦明星; 张书练; 梁晋文

    2001-01-01

    The polarization of a tapered semi-conductor travelling-wave amplifier has been investigated with the transfer matrix method based on convective equation. It is shown that the apparent polarization mode competition exists, and polarization-independent tapered semiconductor travellingwave amplifiers can be obtained through the optimization of amplifier parameters.

  6. IAEA Director General candidates announced

    International Nuclear Information System (INIS)

    Full text: The IAEA today confirms receipt of the nomination of five candidates for Director General of the IAEA. Nominations of the following individuals have been received by the Chairperson of the IAEA Board of Governors, Ms. Taous Feroukhi: Mr. Jean-Pol Poncelet of Belgium; Mr. Yukiya Amano of Japan; Mr. Ernest Petric of Slovenia; Mr. Abdul Samad Minty of South Africa; and Mr. Luis Echavarri of Spain. The five candidates were nominated in line with a process approved by the Board in October 2008. IAEA Director General Mohamed ElBaradei's term of office expires on 30 November 2009. He has served as Director General since 1997 and has stated that he is not available for a fourth term of office. (IAEA)

  7. Enthalpy screen of drug candidates.

    Science.gov (United States)

    Schön, Arne; Freire, Ernesto

    2016-11-15

    The enthalpic and entropic contributions to the binding affinity of drug candidates have been acknowledged to be important determinants of the quality of a drug molecule. These quantities, usually summarized in the thermodynamic signature, provide a rapid assessment of the forces that drive the binding of a ligand. Having access to the thermodynamic signature in the early stages of the drug discovery process will provide critical information towards the selection of the best drug candidates for development. In this paper, the Enthalpy Screen technique is presented. The enthalpy screen allows fast and accurate determination of the binding enthalpy for hundreds of ligands. As such, it appears to be ideally suited to aid in the ranking of the hundreds of hits that are usually identified after standard high throughput screening.

  8. Leishmaniasis: vaccine candidates and perspectives.

    Science.gov (United States)

    Singh, Bhawana; Sundar, Shyam

    2012-06-01

    Leishmania is a protozoan parasite and a causative agent of the various clinical forms of leishmaniasis. High cost, resistance and toxic side effects of traditional drugs entail identification and development of therapeutic alternatives. The sound understanding of parasite biology is key for identifying novel drug targets, that can induce the cell mediated immunity (mainly CD4+ and CD8+ IFN-gamma mediated responses) polarized towards a Th1 response. These aspects are important in designing a new vaccine along with the consideration of the candidates with respect to their ability to raise memory response in order to improve the vaccine performance. This review is an effort to identify molecules according to their homology with the host and their ability to be used as potent vaccine candidates.

  9. Climate change issue table : petroleum downstream sector industry foundation paper

    International Nuclear Information System (INIS)

    An analysis of the impact of the Kyoto Protocol on the Canadian downstream petroleum industry is presented. The downstream sector includes petroleum refining, plus all activities regarding distribution, marketing and retailing of petroleum products. In 1990, the carbon dioxide (CO2) emissions resulting from the production and consumption of petroleum products were about 207 megatons which is about 45 per cent of total Canadian CO2 emissions. This report includes the analysis of the Base Case and the Kyoto Case. The Base Case is premised on the implementation of fuel sulphur reductions to meet cleaner fuels requirements and an enhanced program of refinery efficiency initiatives. Under the Base Case assumptions the CO2 emissions from refinery operations in 2010 would be about 3.4 below 1990 levels. The Kyoto Case was developed on the basis of reductions in Canadian petroleum product demand that would be sufficient to achieve a 6 per cent reduction in GHG emissions from the production and consumption of petroleum products relative to 1990 levels. The model demonstrates the dramatic economic impact of the Kyoto Case reductions on the Canadian downstream petroleum sector. Investment requirements for capital improvements to further distillate production and to further desulphurization are estimated at $ 1.5 billion between 2005 and 2015. The reduced volume of gasoline sales would be expected to result in rationalization of retail outlets, resulting in the closure of some 2,000 retail outlets with a combined loss of about 12,000 jobs. It is suggested that similar impact in other countries that are signatory to the Kyoto Protocol could result in the shift of refining, refining industry jobs and related economic benefits to countries which are not participants in the Kyoto Protocol. 14 tabs., 6 figs., 5 appendices

  10. Growth Characteristics Downstream of a Shallow Bump: Computation and Experiment

    Science.gov (United States)

    Joslin, Ronald D.; Grosch, Chester E.

    1996-01-01

    Measurements of the velocity field created by a shallow bump on a wall revealed that an energy peak in the spanwise spectrum associated with the driver decays and an initially small-amplitude secondary mode rapidly grows with distance downstream of the bump. Linear theories could not provide an explanation for this growing mode. The present Navier-Stokes simulation replicates and confirms the experimental results. Insight into the structure of the flow was obtained from a study of the results of the calculations and is presented.

  11. Recent Molecular Advances on Downstream Plant Responses to Abiotic Stress

    Directory of Open Access Journals (Sweden)

    Cláudia Regina Batista de Souza

    2012-07-01

    Full Text Available Abiotic stresses such as extremes of temperature and pH, high salinity and drought, comprise some of the major factors causing extensive losses to crop production worldwide. Understanding how plants respond and adapt at cellular and molecular levels to continuous environmental changes is a pre-requisite for the generation of resistant or tolerant plants to abiotic stresses. In this review we aimed to present the recent advances on mechanisms of downstream plant responses to abiotic stresses and the use of stress-related genes in the development of genetically engineered crops.

  12. The flow field downstream of a hydraulic jump

    OpenAIRE

    Hornung, Hans G.; Willert, Christian; Turner, Stewart

    1995-01-01

    A control-volume analysis of a hydraulic jump is used to obtain the mean vorticity downstream of the jump as a function of the Froude number. To do this it is necessary to include the conservation of angular momentum. The mean vorticity increases from zero as the cube of Froude number minus one, and, in dimensionless form, approaches a constant at large Froude number. Digital particle imaging velocimetry was applied to travelling hydraulic jumps giving centre-plane velocity field images at a ...

  13. The dual role of lakes as buffers and amplifiers of dissolved organic matter temporal dynamics: Buffering transport and amplifying transformation

    Science.gov (United States)

    Ejarque, Elisabet; Schelker, Jakob; Khan, Samiullah; Hollaus, Lisa-Maria; Steniczka, Gertraud; Kainz, Martin; Battin, Tom

    2016-04-01

    Lakes that disrupt the flow of water and its constituents within the fluvial continuum can modify the downstream dynamics of dissolved organic matter (DOM). Potential causes of this change may include the hydrological buffering capacity of lakes relative to streams and rivers and the amplification of biotic processes. To test this hypothesis, we measured DOM quantity and quality at the inflow and outflow of sub-alpine Lake Lunz (Lower Austria) during one year. DOM quality was characterised using optical metrics indicative of the humic-like composition (fluorescence peak C), humification (HIX), and aromaticity (SUVA) degree, predominance of autochthonous components (BIX), and average molecular weight (E2:E3). Total annual variability was found to be lower in the outflow compared with the inflow (SDout:SDin 1). This was due to the large seasonal variability in the outflow, which contrasted with a reduced temporal dynamics in the inflow. Combined, this created a shift from similar inflow-outflow DOM characteristics during winter, to uncoupled DOM characteristics during summer. This uncoupling consisted in a higher signal of the autotrophic origin of DOM, a lower average molecular weight, as well as a lower aromatic and humic-like content in the outflow. Overall, these results highlight the role of the Lake Lunz as a DOC source and as a buffer of hydrological pulses of DOC export. Moreover, results emphasise the capacity of the lake to amplify the seasonal variability of DOM quality, creating a maximum uncoupling between the inflow and the outflow during the months of increased biotic processing in the lake.

  14. Analysis of multipass laser amplifier systems for storage laser media

    International Nuclear Information System (INIS)

    The performance characteristics of single pass and multipass storage laser amplifiers are presented and compared. The effects of the multipass amplifier parameters on the extraction characteristics are examined. For a wide range of conditions the multipass amplifier is found to provide high energy gain and high efficiency simultaneously. This is a significant advantage over the single pass laser amplifier. Finally, three specific storage laser amplifier systems, flashlamp pumped V:MgF2, XeF laser pumped Tm:Glass, and photolytically pumped Selenium, are examined. The performance characteristics for each of the three systems are calculated and compared

  15. Analysis of multipass laser amplifier systems for storage laser media

    Energy Technology Data Exchange (ETDEWEB)

    Harvey, J.F.

    1980-03-25

    The performance characteristics of single pass and multipass storage laser amplifiers are presented and compared. The effects of the multipass amplifier parameters on the extraction characteristics are examined. For a wide range of conditions the multipass amplifier is found to provide high energy gain and high efficiency simultaneously. This is a significant advantage over the single pass laser amplifier. Finally, three specific storage laser amplifier systems, flashlamp pumped V:MgF/sub 2/, XeF laser pumped Tm:Glass, and photolytically pumped Selenium, are examined. The performance characteristics for each of the three systems are calculated and compared.

  16. Characterization of a Common-Gate Amplifier Using Ferroelectric Transistors

    Science.gov (United States)

    Hunt, Mitchell; Sayyah, Rana; MacLeod, Todd C.; Ho, Fat D.

    2011-01-01

    In this paper, the empirical data collected through experiments performed using a FeFET in the common-gate amplifier circuit is presented. The FeFET common-gate amplifier was characterized by varying all parameters in the circuit, such as load resistance, biasing of the transistor, and input voltages. Due to the polarization of the ferroelectric layer, the particular behavior of the FeFET common-gate amplifier presents interesting results. Furthermore, the differences between a FeFET common-gate amplifier and a MOSFET common-gate amplifier are examined.

  17. Characterization of a Common-Source Amplifier Using Ferroelectric Transistors

    Science.gov (United States)

    Hunt, Mitchell; Sayyah, Rana; MacLeond, Todd C.; Ho, Pat D.

    2010-01-01

    This paper presents empirical data that was collected through experiments using a FeFET in the established common-source amplifier circuit. The unique behavior of the FeFET lends itself to interesting and useful operation in this widely used common-source amplifier. The paper examines the effect of using a ferroelectric transistor for the amplifier. It also examines the effects of varying load resistance, biasing, and input voltages on the output signal and gives several examples of the output of the amplifier for a given input. The difference between a commonsource amplifier using a ferroelectric transistor and that using a MOSFET is addressed.

  18. Mapping of Candidate Genes Involved in Bud Dormancy and Flowering Time in Sweet Cherry (Prunus avium.

    Directory of Open Access Journals (Sweden)

    Sophie Castède

    Full Text Available The timing of flowering in perennial plants is crucial for their survival in temperate climates and is regulated by the duration of bud dormancy. Bud dormancy release and bud break depend on the perception of cumulative chilling during endodormancy and heat during the bud development. The objectives of this work were to identify candidate genes involved in dormancy and flowering processes in sweet cherry, their mapping in two mapping progenies 'Regina' × 'Garnet' and 'Regina' × 'Lapins', and to select those candidate genes which co-localized with quantitative trait loci (QTLs associated with temperature requirements for bud dormancy release and flowering. Based on available data on flowering processes in various species, a list of 79 candidate genes was established. The peach and sweet cherry orthologs were identified and primers were designed to amplify sweet cherry candidate gene fragments. Based on the amplified sequences of the three parents of the mapping progenies, SNPs segregations in the progenies were identified. Thirty five candidate genes were genetically mapped in at least one of the two progenies and all were in silico mapped. Co-localization between candidate genes and QTLs associated with temperature requirements and flowering date were identified for the first time in sweet cherry. The allelic composition of the candidate genes located in the major QTL for heat requirements and flowering date located on linkage group 4 have a significant effect on these two traits indicating their potential use for breeding programs in sweet cherry to select new varieties adapted to putative future climatic conditions.

  19. Mapping of Candidate Genes Involved in Bud Dormancy and Flowering Time in Sweet Cherry (Prunus avium).

    Science.gov (United States)

    Castède, Sophie; Campoy, José Antonio; Le Dantec, Loïck; Quero-García, José; Barreneche, Teresa; Wenden, Bénédicte; Dirlewanger, Elisabeth

    2015-01-01

    The timing of flowering in perennial plants is crucial for their survival in temperate climates and is regulated by the duration of bud dormancy. Bud dormancy release and bud break depend on the perception of cumulative chilling during endodormancy and heat during the bud development. The objectives of this work were to identify candidate genes involved in dormancy and flowering processes in sweet cherry, their mapping in two mapping progenies 'Regina' × 'Garnet' and 'Regina' × 'Lapins', and to select those candidate genes which co-localized with quantitative trait loci (QTLs) associated with temperature requirements for bud dormancy release and flowering. Based on available data on flowering processes in various species, a list of 79 candidate genes was established. The peach and sweet cherry orthologs were identified and primers were designed to amplify sweet cherry candidate gene fragments. Based on the amplified sequences of the three parents of the mapping progenies, SNPs segregations in the progenies were identified. Thirty five candidate genes were genetically mapped in at least one of the two progenies and all were in silico mapped. Co-localization between candidate genes and QTLs associated with temperature requirements and flowering date were identified for the first time in sweet cherry. The allelic composition of the candidate genes located in the major QTL for heat requirements and flowering date located on linkage group 4 have a significant effect on these two traits indicating their potential use for breeding programs in sweet cherry to select new varieties adapted to putative future climatic conditions. PMID:26587668

  20. Experiments in a combined up stream downstream slug flow

    Directory of Open Access Journals (Sweden)

    Toledo-Velázquez M.

    2013-04-01

    Full Text Available Slug flow induced by the combination of a downstream and an upstream two phase flow is very common in the oil industry, mainly when the pipelines are installed on hilly terrains. This phenomenon can be dangerous for the equipment operation because it induces vibrations due to the slugs intermittent movement into the separators. A loop, where it is possible to change the flow conditions and the loop geometrical parameters as the length and inclination angle of the pipe sections was built. Instruments for slug detection and for measuring their characteristic parameters as hold up, frequency, length, and velocity were installed. Three conductive probes were used for the hold-up measurement in different points; all of them were designed, constructed, tested andcalibrated. Experimental runs for a set of four alternated sections upstream downstream W shaped pipe have been undertaken. The gas and liquid flow rates were selected in order to obtain stratified flow at the inlet, which is the condition to induce the severe slugging. The main conclusions of the experimental results analysis are presented in this paper. The Barnea's criterion has been compared against our experimental results, three slugging regions have been found.

  1. Initial PVO Evidence of Electron Depletion Signatures Downstream of Venus

    Science.gov (United States)

    Intriligator, D. S.; Hartle, R. E.; Perez-de-Tejada, H.; Siscoe, G. L.

    1993-01-01

    This first analysis of Pioneer Venus Orbiter (PVO) plasma analyzer electron measurements obtained in early 1992 during the PVO entry phase of the mission indicates the presence downstream from the terminator of a depletion or "bite out" of energetic ionosheath electrons similar to that observed on Mariner 10. There is more than one possible explanation for this energetic electron depletion. If it is due to atmospheric scattering, the electrons traveling along draped magnetic flux tubes that thread through the Venus neutral atmosphere would lose energy from impact ionization with oxygen. The cross-section for such electron impact ionization of oxygen has a peak near 100 eV, and it remains high above this energy, so atmospheric loss could provide a natural process for electrons at these energies to be selectively removed. In this case, our results are consistent with the Kar et al. (1994) study of PVO atmospheric entry ion mass spectrometer data which indicates that electron impact plays a significant role in maintaining the nightside ionosphere. Although it is appealing to interpret the energetic electron depletion in terms of direct atmospheric scattering, alternatively it could result from strong draping which connects the depletion region magnetically to the weak downstream bow shock and thereby reduces the electron source strength.

  2. Flow downstream of the heliospheric terminal shock. I - Irrotational flow

    Science.gov (United States)

    Suess, Steven T.; Nerney, Steven

    1990-01-01

    Recent reports of remote detection of the heliospheric terminal shock place it near 50 AU. These conflict with standard models which, when combined with current data on the local interstellar medium, place the shock beyod 100 AU. Resolution of this discrepancy has led to hypotheses that invoke cosmic ray pressure, momentum exchange with interstellar neutrals, and magnetic field effects between the shock and the contact discontinuity dividing the solar wind from interstellar plasma. These hypotheses depend not only on properties of the interstellar medium, but also on the downstream three-dimensional flow between the shock and the contact discontinuity, in the region called the 'heliosheath'. The downstream flow field in the absence of magnetic fields is examined here under the assumptions that the flow everywhere outside the shock can be approximated as irrotational and incompressible. It is found, in particular, that the distance between the terminal shock and the contact discontinuity is less than the heliocentric distance to the terminal shock, effectively eliminating magnetic field effects in the heliosheath as being dynamically important.

  3. Vortex structures downstream a lobed nozzle/mixer

    Institute of Scientific and Technical Information of China (English)

    Hui Hu; Toshio Kobayashi

    2008-01-01

    An experimental study was conducted to investigate the evolutions of unsteady vortex structures downstream a lobed mixer/nozzle. A novel dual-plane stereoscopic PIV system was used to measure all 3-components of vorticity distributions to revealed both the large-scale streamwise vortices produced by the lobed mixer/nozzle and the Kelvin-Helmholtz vortex structures generated due to the Kelvin-Helmholtz instabilities simultaneously and quantitatively for the first time. The instantaneous and the ensemble-averaged vorticity distributions displayed quite different aspects about the evolutions of the unsteady vortex structures. While the ensemble-averaged vorticity distributions indicated the overall effect of the special geometry of the lobed nozzle/mixer on the enhanced mixing process, the instantaneous vorticity distributions elucidated many details about how the enhanced mixing process was conducted. In addition to quantitatively confirming conjectures of previous studies, further insight about the formation, evolution and interaction characteristics of the unsteady vortex structures downstream of the lobed mixer/nozzle were also uncovered quantitatively in the present study.

  4. Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors.

    Directory of Open Access Journals (Sweden)

    Hannah Karlsson

    Full Text Available CD19-targeting CAR T cells have shown potency in clinical trials targeting B cell leukemia. Although mainly second generation (2G CARs carrying CD28 or 4-1BB have been investigated in patients, preclinical studies suggest that third generation (3G CARs with both CD28 and 4-1BB have enhanced capacity. However, little is known about the intracellular signaling pathways downstream of CARs. In the present work, we have analyzed the signaling capacity post antigen stimulation in both 2G and 3G CARs. 3G CAR T cells expanded better than 2G CAR T cells upon repeated stimulation with IL-2 and autologous B cells. An antigen-driven accumulation of CAR+ cells was evident post antigen stimulation. The cytotoxicity of both 2G and 3G CAR T cells was maintained by repeated stimulation. The phosphorylation status of intracellular signaling proteins post antigen stimulation showed that 3G CAR T cells had a higher activation status than 2G. Several proteins involved in signaling downstream the TCR were activated, as were proteins involved in the cell cycle, cell adhesion and exocytosis. In conclusion, 3G CAR T cells had a higher degree of intracellular signaling activity than 2G CARs which may explain the increased proliferative capacity seen in 3G CAR T cells. The study also indicates that there may be other signaling pathways to consider when designing or evaluating new generations of CARs.

  5. Low power RF amplifier circuit for ion trap applications

    Science.gov (United States)

    Noriega, J. R.; García-Delgado, L. A.; Gómez-Fuentes, R.; García-Juárez, A.

    2016-09-01

    A low power RF amplifier circuit for ion trap applications is presented and described. The amplifier is based on a class-D half-bridge amplifier with a voltage mirror driver. The RF amplifier is composed of an RF class-D amplifier, an envelope modulator to ramp up the RF voltage during the ion analysis stage, a detector or amplitude demodulation circuit for sensing the output signal amplitude, and a feedback amplifier that linearizes the steady state output of the amplifier. The RF frequency is set by a crystal oscillator and the series resonant circuit is tuned to the oscillator frequency. The resonant circuit components have been chosen, in this case, to operate at 1 MHz. In testings, the class-D stage operated at a maximum of 78 mW at 1.1356 MHz producing 225 V peak.

  6. K-band FET amplifier for satellite downlink

    Science.gov (United States)

    Goel, J.; Cheung, R. P.

    1984-01-01

    State-of-the-art performance is demonstrated with solid-state amplifiers in K-band. The amplifier provides 8.2 watts of power with 39 dB gain over a frequency band of 1.4 GHz. Nonlinearity analyses of solid-state amplifiers suggest that system performance can be improved significantly by using an FET amplifier. Preliminary investigations reveal that the solid-state amplifiers can be space-qualified and can be expected to replace the TWTA in many communication links in the near future. It is pointed out that with improvements in device technology, the power, bandwidth and efficiency of solid-state amplifiers using FETs can be further improved. With FETs operating at a junction temperature of less than 125 C, solid-state amplifiers are inherently reliable, indicating a ten-year mean time to failure.

  7. Investigations of electronic amplifiers supplying a piezobimorph actuator

    Science.gov (United States)

    Milecki, Andrzej; Regulski, Roman

    2016-10-01

    Piezoelectric bending actuators, also known as bimorphs, are characterized by very good dynamic properties and by displacements in a range of a few millimeters. Therefore these actuators are used in a wide range of applications. However their usage is limited because they require supplying amplifiers with output voltage of about 200 V, which are rather expensive. This paper presents investigation results of such amplifiers with high voltage output. The model of a piezobending actuator is proposed and implemented in Matlab-Simulink software in order to simulate the behavior of the actuator supplied by the amplifiers. The simulation results are presented and compared with investigation results of high voltage amplifier used for supplying a piezoactuator. The influence of current limitation of operational amplifier on the actuator current is tested. Finally, a low cost audio power amplifier is proposed to control the piezobender actuator (as a cheaper alternative to the high-voltage amplifier) and its investigations results are presented in the paper.

  8. Time amplifying techniques towards atomic time resolution

    Institute of Scientific and Technical Information of China (English)

    LI JingZhen

    2009-01-01

    High speed imaging technology has opened applications in many fields,such as collision,detonating,high voltage discharge,disintegration and transfer of phonon and exciton in solid,photosynthesis primitive reaction,and electron dynamics inside atom shell.In principle,all of the transient processes need to be explained theoretically and,st the same time,the time amplifying technique is required for observations of these processes.The present review concerns the atomic time amplifying mechanism of optical information and the extremely-high speed imaging methods,which are expressed in terms of the short time amplifying techniques.It is well-known that for extremely-high speed imaging with the converter tube,the temporal resolution is in the order of sub-picosecond of the streak imaging,and the imaging frequency is 6×10~8-5×10~9 fps(frame per second)of the frame imaging.On the other hand,for the tubeless extremely-high speed imaging,the imaging frequency is 10~7-10~(14) fps,and its mechanism of forming high speed and framing could involve a lot of factors of the light under investigation,for instance,light speed,light parallelism,the parameters of light wave such as amplitude,phase,polarization and wavelength,and even quantum properties of photon.In the cascaded system of electromagnetic wave and particle wave,it is possible to simultaneously realize extremely-high resolution in time and space,which is higher than a kite resolution.Then it would be possible to break the limit of the Heisenberg uncertainty relation of the optical frequency band.

  9. Time amplifying techniques towards atomic time resolution

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    High speed imaging technology has opened applications in many fields,such as collision,detonating, high voltage discharge,disintegration and transfer of phonon and exciton in solid,photosynthesis primitive reaction,and electron dynamics inside atom shell.In principle,all of the transient processes need to be explained theoretically and,at the same time,the time amplifying technique is required for observations of these processes.The present review concerns the atomic time amplifying mechanism of optical information and the extremely-high speed imaging methods,which are expressed in terms of the short time amplifying techniques.It is well-known that for extremely-high speed imaging with the converter tube,the temporal resolution is in the order of sub-picosecond of the streak imaging,and the imaging frequency is 6×10 8 ―5×10 9 fps(frame per second)of the frame imaging.On the other hand,for the tubeless extremely-high speed imaging,the imaging frequency is 10 7 ―10 14 fps,and its mechanism of forming high speed and framing could involve a lot of factors of the light under investigation,for instance,light speed,light parallelism,the parameters of light wave such as amplitude,phase,polari- zation and wavelength,and even quantum properties of photon.In the cascaded system of electro- magnetic wave and particle wave,it is possible to simultaneously realize extremely-high resolution in time and space,which is higher than a kite resolution.Then it would be possible to break the limit of the Heisenberg uncertainty relation of the optical frequency band.

  10. High sensitivity amplifier/discriminator for PWC's

    International Nuclear Information System (INIS)

    The facility support group at Fermilab is designing and building a general purpose beam chamber for use in several locations at the laboratory. This pwc has 128 wires per plane spaced 1 mm apart. An initial production of 25 signal planes is anticipated. In proportional chambers, the size of the signal depends exponentially on the charge stored per unit of length along the anode wire. As the wire spacing decreases, the capacitance per unit length decreases, thereby requiring increased applied voltage to restore the necessary charge per unit length. In practical terms, this phenomenon is responsible for difficulties in constructing chambers with less than 2 mm wire spacing. 1 mm chambers, therefore, are frequently operated very near to their breakdown point and/or a high gain gas containing organic compounds such as magic gas is used. This argon/iso-butane mixture has three drawbacks: it is explosive when exposed to the air, it leaves a residue on the wires after extended use and is costly. An amplifier with higher sensitivity would reduce the problems associated with operating chambers with small wire spacings and allow them to be run a safe margin below their breakdown voltage even with an inorganic gas mixture such as argon/CO2, this eliminating the need to use magic gas. Described here is a low cost amplifier with a usable threshold of less than 0.5 μA. Data on the performance of this amplifier/discriminator in operation on a prototype beam chamber are given. This data shows the advantages of the high sensitivity of this design

  11. Undulations from amplified low frequency surface waves

    CERN Document Server

    Coutant, Antonin

    2012-01-01

    We study the scattering of gravity waves in longitudinal stationary flows. When the flow velocity becomes supercritical, counterflow propagating waves are amplified in such a way that, in the zero-frequency limit, the free surface develops an undu- lation, i.e., a zero-frequency wave of large amplitude with nodes located at specific places. From this, we show that the unperturbed flat surface is unstable against perturbations of arbitrary small amplitude. We then show that this instability also appears when treating low frequency waves by a stochastic ensemble. The relation between the generation of undulations and black hole radiation (the Hawking effect) is discussed.

  12. Envelope tracking power amplifiers for wireless communications

    CERN Document Server

    Wang, Zhancang

    2014-01-01

    Envelope tracking technology is seen as the most promising efficiency enhancement technology for RF power amplifiers for 4G and beyond wireless communications. More and more organizations are investing and researching on this topic with huge potential in academic and commercial areas.This is the first book on the market to offer complete introduction, theory, and design considerations on envelope tracking for wireless communications. This resource presents you with a full introduction to the subject and covers underlying theory and practical design considerations.

  13. Silicon on Insulator MESFETs for RF Amplifiers.

    Science.gov (United States)

    Wilk, Seth J; Balijepalli, Asha; Ervin, Joseph; Lepkowski, William; Thornton, Trevor J

    2010-03-01

    CMOS compatible, high voltage SOI MESFETs have been fabricated using a standard 3.3V CMOS process without any changes to the process flow. A 0.6μm gate length device operates with a cut-off frequency of 7.3GHz and a maximum oscillation frequency of 21GHz. There is no degradation in device performance up to its breakdown voltage, which greatly exceeds that of CMOS devices on the same process. Other figures of merit of relevance to RF front-end design are presented, including the maximum stable gain and noise figure. An accurate representation of the device in SPICE has been developed using the commercially available TOM3 model. Using the SOI MESFET model, a source degenerated low noise RF amplifier targeting operation near 1GHz has been designed. The amplifier was fabricated on a PCB board and operates at 940MHz with a minimum NF of 3.8dB and RF gain of 9.9dB while only consuming 5mW of DC power. PMID:20657816

  14. Design criteria for ultrafast optical parametric amplifiers

    Science.gov (United States)

    Manzoni, C.; Cerullo, G.

    2016-10-01

    Optical parametric amplifiers (OPAs) exploit second-order nonlinearity to transfer energy from a fixed frequency pump pulse to a variable frequency signal pulse, and represent an easy way of tuning over a broad range the frequency of an otherwise fixed femtosecond laser system. OPAs can also act as broadband amplifiers, transferring energy from a narrowband pump to a broadband signal and thus considerably shortening the duration of the pump pulse. Due to these unique properties, OPAs are nowadays ubiquitous in ultrafast laser laboratories, and are employed by many users, such as solid state physicists, atomic/molecular physicists, chemists and biologists, who are not experts in ultrafast optics. This tutorial paper aims at providing the non-specialist reader with a self-consistent guide to the physical foundations of OPAs, deriving the main equations describing their performance and discussing how they can be used to understand their most important working parameters (frequency tunability, bandwidth, pulse energy/repetition rate scalability, control over the carrier-envelope phase of the generated pulses). Based on this analysis, we derive practical design criteria for OPAs, showing how their performance depends on the type of the nonlinear interaction (crystal type, phase-matching configuration, crystal length), on the characteristics of the pump pulse (frequency, duration, energy, repetition rate) and on the OPA architecture.

  15. Ultrastable low-noise current amplifier

    CERN Document Server

    Drung, Dietmar; Becker, Ulrich; Scherer, Hansjörg; Ahlers, Franz Josef

    2014-01-01

    An ultrastable low-noise current amplifier (ULCA) is presented. The ULCA is a non-cryogenic instrument based on specially designed operational amplifiers and resistor networks. It involves two stages, the first providing a 1000-fold current gain and the second performing a current-to-voltage conversion via an internal 1 MOhm reference resistor or, optionally, an external standard resistor. The ULCA's transfer coefficient is extremely stable versus time, temperature and current amplitude within the full dynamic range of +/-5 nA. A low noise level of 2.4 fA/sqrt(Hz) helps to keep averaging times low at small input currents. A cryogenic current comparator is used to calibrate both input current gain and output transresistance, providing traceability to the quantum Hall effect. Typically, within one day after calibration, the uncertainty contribution from short-term fluctuations of the transresistance is below one part in 10^7. The long-term stability is expected to be better than one part in 10^5 over a year. A ...

  16. From gravel to sand. Downstream fining of bed sediments in the lower river Rhine

    NARCIS (Netherlands)

    Frings, R.M.

    2007-01-01

    A common characteristic of many rivers is the tendency for bed sediments to become finer in downstream direction. This phenomenon, which is generally known as downstream fining, has a strong effect on the morphologic and hydrodynamic behaviour of a river. The fundamental causes of downstream finin

  17. 19 CFR 351.223 - Procedures for initiation of downstream product monitoring.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Procedures for initiation of downstream product... initiation of downstream product monitoring. (a) Introduction. Section 780 of the Act establishes a mechanism for monitoring imports of “downstream products.” In general, section 780 is aimed at situations...

  18. 40 CFR 80.210 - What sulfur standards apply to gasoline downstream from refineries and importers?

    Science.gov (United States)

    2010-07-01

    ... gasoline downstream from refineries and importers? 80.210 Section 80.210 Protection of Environment... Gasoline Sulfur Gasoline Sulfur Standards § 80.210 What sulfur standards apply to gasoline downstream from... downstream from refineries and import facilities, including gasoline at facilities of distributors,...

  19. Downstream properties of magnetic flux transfer events. [in magnetosphere

    Science.gov (United States)

    Sibeck, D. G.; Siscoe, G. L.

    1984-01-01

    Attention is given to the downstream evolution of the field line tubes known as 'flux transfer events' (FTEs), whose magnetic field and plasma properties are distinct from those of the nearby unmerged magnetosheath and magnetosphere field lines. After the FTE has moved 200 earth radii down the tail, its drained portion reaches 25 earth radii radially outward from the tail boundary. It is suggested that most multiple crossings of the tail boundary observed by spacecraft are encounters with tailward-moving FTEs, thereby explaining both the behavior of boundary normals during multiple crossings and how the sign of the IMF causes the observed dawn-dusk asymmetries in the thickness of the magnetotail boundary layer.

  20. Ethiopia's Grand Renaissance Dam: Implications for Downstream Riparian Countries

    Science.gov (United States)

    Zhang, Y.; Block, P. J.; Hammond, M.; King, A.

    2013-12-01

    Ethiopia has begun seriously developing their significant hydropower potential by launching construction of the Grand Ethiopian Renaissance Dam (GERD) on the Blue Nile River to facilitate local and regional growth. Although this has required substantial planning on Ethiopia's part, no policy dictating the reservoir filling rate strategy has been publicly issued. This filling stage will have clear implications on downstream flows in Sudan and Egypt, complicated by evaporative losses, climate variability, and climate change. In this study, various filling policies and future climate states are simultaneously explored to infer potential streamflow reductions at Lake Nasser, providing regional decision-makers with a set of plausible, justifiable, and comparable outcomes. Schematic of the model framework Box plots of 2017-2032 percent change in annual average streamflow at Lake Nasser for each filling policy constructed from the 100 time-series and weighted precipitation changes. All values are relative to the no dam policy and no changes to future precipitation.

  1. 'Patents and Downstream Innovation Suppression - Fact or Fiction?'

    DEFF Research Database (Denmark)

    Howells, John

    Merges and Nelson have provided an empirically grounded argument that firms use pioneer patents of 'broad' scope to block downstream technological development (Merges and Nelson 1990). If this is a regular occurrence then, as they claim, they have faulted Kitch's 'prospect theory' of patents (Kitch...... 1977), a theory that is a version of the classic justification for the award of the exclusive right - that it should protect the incentive to develop property. Merges and Nelson insist that their thesis should be supported by empirical evidence and they turn to historical accounts as an important form...... in development in these same technologies. The paper finds that, first, the award of 'broad' scope is only implicated in one of the examples presented, second, that strict development block (understood as a retardation of development rate below some demonstrable and potentially higher rate) is not illustrated...

  2. Downstream and upstream extension of the House of Quality

    DEFF Research Database (Denmark)

    Holmen, Elsebeth; Kristensen, Preben Sander

    Executive summary 1. During 1993-94 the authors followed a product development process in a Danish butter cookie company. The process was structured according to the Quality Function Deployment technique House of Quality. Originally, the intention was to study the prototyping process that we...... for product development, we suggest ad incompatibility matrix to the traditional House of Quality. 3. Upstream, most product characteristics were deployed to internal company functions. In addition, some characteristics were deployed to potential suppliers. In this way the departments and firms that seemed...... a discussion in a diabetics end-user focus group. During a series of meetings, the production manager and the sales manager transformed attributes int characteristics and constructed Houses of Quality for a sugar-free cookie. 2. Downstream on its way to the end-user, the product passes through a chain of users...

  3. Regulatory network of inflammation downstream of proteinase-activated receptors

    Directory of Open Access Journals (Sweden)

    Hurst Robert E

    2007-03-01

    Full Text Available Abstract Background Protease-activated receptors (PAR are present in the urinary bladder, and their expression is altered in response to inflammation. PARs are a unique class of G protein-coupled that carry their own ligands, which remain cryptic until unmasked by proteolytic cleavage. Although the canonical signal transduction pathway downstream of PAR activation and coupling with various G proteins is known and leads to the rapid transcription of genes involved in inflammation, the effect of PAR activation on the downstream transcriptome is unknown. We have shown that intravesical administration of PAR-activating peptides leads to an inflammatory reaction characterized by edema and granulocyte infiltration. Moreover, the inflammatory response to intravesical instillation of known pro-inflammatory stimuli such as E. coli lipopolysaccharide (LPS, substance P (SP, and antigen was strongly attenuated by PAR1- and to a lesser extent by PAR2-deficiency. Results Here, cDNA array experiments determined inflammatory genes whose expression is dependent on PAR1 activation. For this purpose, we compared the alteration in gene expression in wild type and PAR1-/- mice induced by classical pro-inflammatory stimuli (LPS, SP, and antigen. 75 transcripts were considered to be dependent on PAR-1 activation and further annotated in silico by Ingenuity Pathways Analysis (IPA and gene ontology (GO. Selected transcripts were target validated by quantitative PCR (Q-PCR. Among PAR1-dependent transcripts, the following have been implicated in the inflammatory process: b2m, ccl7, cd200, cd63, cdbpd, cfl1, dusp1, fkbp1a, fth1, hspb1, marcksl1, mmp2, myo5a, nfkbia, pax1, plaur, ppia, ptpn1, ptprcap, s100a10, sim2, and tnfaip2. However, a balanced response to signals of injury requires a transient cellular activation of a panel of genes together with inhibitory systems that temper the overwhelming inflammation. In this context, the activation of genes such as dusp1 and

  4. Efficient industry configurations in downstream gas markets. An empirical assessment

    Energy Technology Data Exchange (ETDEWEB)

    Casarin, Ariel A. [IAE Escuela de Direccion y Negocios, Universidad Austral, Buenos Aires (Argentina)

    2007-03-15

    This paper examines the production technology of the downstream gas industry in order to provide some useful insights into its efficient structure by looking at the optimal size of firms and the productive efficiency reasons for and against their vertical integration. The analysis is based on a restricted cost function model estimated using firm level data for Argentina and Great Britain. The findings provide evidence for the presence of vertical diseconomies between stages. Results indicate that a single transmitter is able to produce the industry's output at lower costs for large market sizes and that several regional firms are able to operate without sacrificing scale economies if gas distribution is integrated with supply. The findings also indicate that a gas retailer experiences constant returns to scale when it supplies a large customer base. Liberalisation could thus result in oligopolistic industry configurations. (Author)

  5. A Copernicus downstream service for surface displacement monitoring in Germany

    Science.gov (United States)

    Cahyadi Kalia, Andre; Frei, Michaela; Lege, Thomas

    2016-04-01

    SAR Interferometry is a powerful technique able to detect and monitor various surface displacements caused by e.g. gravitative mass movement, subrosion, groundwater extraction, fluid injection, natural gas extraction. These processes can e.g. cause damage to buildings, infrastructure, affect ecosystems, agriculture and the economic use of the geological underground by influencing the hydro(geo)logical setting. Advanced techniques of interferometric processing (Persistent Scatterer Interferometry, PSI) allow highly precise displacement measurements (mm precision) by analyzing stacks of SAR imagery. The PSI mapping coverage can be increased to entire nations by using several adjacent satellite tracks. In order to assist the operational use of this technique a German-wide, officially approved, PSI dataset is under development. The intention of this presentation is to show i) the concept of the Copernicus downstream service for surface displacement monitoring in Germany and ii) a pilot study to exemplarily demonstrate the workflow and potential products from the Copernicus downstream service. The pilot study is focusing on the built up of an officially approved wide-area PSI dataset. The study area covers an area of more than 30.000 km² and is located in the Northwest German Basin. Several natural processes (e.g. compaction of marine sediments, peat loss) and anthropogenic activities (e.g. natural gas extraction, rock salt mining) are causing surface displacements in the study area. The PSI analysis is based on six ERS-1/-2 data stacks covering the timespan from 1992 until 2001. Each data stack consists of 49 to 73 ERS-1/-2 SAR images. A comparison of the PSI results with thematic data (e.g. volume and location of extracted natural gas) strongly indicates that a part of the detected land subsidence is caused by natural gas extraction. Furthermore, land subsidence caused by e.g. fluid injection and rock salt mining were successfully detected by the PSI analysis.

  6. Downstream evolution of unconfined vortices: mechanical and thermal aspects

    Science.gov (United States)

    Pérez-Saborid, M.; Herrada, M. A.; Gómez-Barea, A.; Barrero, A.

    2002-11-01

    We present a numerical study of the downstream evolution (mechanical and thermal) of vortex-jet cores whose velocity and temperature fields far from the axis match a family of inviscid and non-conducting vortices. The far-velocity field is rotational, except for a particular case which corresponds to the well-known Long's vortex. The evolution of the vortex core depends on both the conditions at a certain upstream station, characterized by the dimensionless value of the velocity at the axis, and a dimensionless swirling parameter L defined as the ratio of the values of the azimuthal and axial velocities outside the vortex core. This numerical study, based on the quasi-cylindrical approximation (QC) of the Navier Stokes equations, determines the conditions under which the vortex evolution proceeds smoothly, eventually reaching an asymptotic self-similar behaviour as described in the literature (Fernández-Feria, Fernández de la Mora & Barrero 1995; Herrada, Pérez-Saborid & Barrero 1999), or breaks in a non-slender solution (vortex breakdown). In particular, the critical value L = Lb(a) beyond which vortex breakdown occurs downstream is a function of a dimensionless parameter a characterizing the axial momentum of the vortex jet at an initial upstream station. It is found numerically that for very large values of a this vortex breakdown criterion tends to an asymptote which is precisely the value L = L* predicted by the self-similar analysis, and beyond which a self-similar structure of the vortex core does not exist. In addition, the computation of the total temperature field provides useful information on the physical mechanisms responsible for the thermal separation phenomenon observed in Ranque Hilsch tubes and other swirling jet devices. In particular, the mechanical work of viscous forces which gives rise to an intense loss of kinetic energy during the initial stages of the evolution has been identified as the physical mechanism responsible for thermal

  7. Downstream cumulative effects of land use on freshwater communities

    Science.gov (United States)

    Kuglerová, L.; Kielstra, B. W.; Moore, D.; Richardson, J. S.

    2015-12-01

    Many streams and rivers are subject to disturbance from intense land use such as urbanization and agriculture, and this is especially obvious for small headwaters. Streams are spatially organized into networks where headwaters represent the tributaries and provide water, nutrients, and organic material to the main stems. Therefore perturbations within the headwaters might be cumulatively carried on downstream. Although we know that the disturbance of headwaters in urban and agricultural landscapes poses threats to downstream river reaches, the magnitude and severity of these changes for ecological communities is less known. We studied stream networks along a gradient of disturbance connected to land use intensity, from urbanized watersheds to watersheds placed in agricultural settings in the Greater Toronto Area. Further, we compared the patterns and processes found in the modified watershed to a control watershed, situated in a forested, less impacted landscape. Preliminary results suggest that hydrological modifications (flash floods), habitat loss (drainage and sewer systems), and water quality issues of small streams in urbanized and agricultural watersheds represent major disturbances and threats for aquatic and riparian biota on local as well as larger spatial scales. For example, communities of riparian plants are dominated by species typical of the land use on adjacent uplands as well as the dominant land use on the upstream contributing area, instead of riparian obligates commonly found in forested watersheds. Further, riparian communities in disturbed environments are dominated by invasive species. The changes in riparian communities are vital for various functions of riparian vegetation. Bank erosion control is suppressed, leading to severe channel transformations and sediment loadings in urbanized watersheds. Food sources for instream biota and thermal regimes are also changed, which further triggers alterations of in-stream biological communities

  8. 11 CFR 100.154 - Candidate debates.

    Science.gov (United States)

    2010-01-01

    ... Expenditures § 100.154 Candidate debates. Funds used to defray costs incurred in staging candidate debates in accordance with the provisions of 11 CFR 110.13 and 114.4(f) are not expenditures. ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Candidate debates. 100.154 Section...

  9. 11 CFR 100.92 - Candidate debates.

    Science.gov (United States)

    2010-01-01

    ... Contributions § 100.92 Candidate debates. Funds provided to defray costs incurred in staging candidate debates in accordance with the provisions of 11 CFR 110.13 and 114.4(f) are not contributions. ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Candidate debates. 100.92 Section...

  10. No Evidence for Association between Amelogenesis Imperfecta and Candidate Genes

    Directory of Open Access Journals (Sweden)

    M Ghandehari Motlagh

    2009-03-01

    Full Text Available "nBackground: Amelogenesis imperfecta (AI is an inherited tooth disorder. Despite the fact that up to now, several gene muta­tions in MMP20, ENAM, AMELX and KLK4 genes have been reported to be associated with AI, many other genes sug­gested to be involved. The main objective of this study was to find the mutations in three major candidate genes including MMP20, ENAM and KLK4 responsible for AI from three Iranian families with generalized hypoplastic phenotype in all teeth. "nMethods: All exon/intron boundaries of subjected genes were amplified by polymerase chain reaction and subjected to direct sequencing."nResults: One polymorphisms was identified in KLK4 exon 2, in one family a homozygous mutation was found in the third base of codon 22 for serine (TCG>TCT, but not in other families. Although these base substitutions have been occurred in the signaling domain, they do not seem to influence the activity of KLK4 protein."nConclusion: Our results might support the further evidence for genetic heterogeneity; at least, in some AI cases are not caused by a gene in these reported candidate genes.

  11. Direct coupled amplifiers using field effect transistors

    International Nuclear Information System (INIS)

    The concept of the uni-polar field effect transistor (P.E.T.) was known before the invention of the bi-polar transistor but it is only recently that they have been made commercially. Being produced as yet only in small quantities, their price imposes a restriction on use to circuits where their peculiar properties can be exploited to the full. One such application is described here where the combination of low voltage drift and relatively low input leakage current are necessarily used together. One of the instruments used to control nuclear reactors has a logarithmic response to the mean output current from a polarised ionisation chamber. The logarithmic signal is then differentiated electrically, the result being displayed on a meter calibrated to show the reactor divergence or doubling time. If displayed in doubling time the scale is calibrated reciprocally. Because of the wide range obtained in the logarithmic section and the limited supply voltage, an output of 1 volt per decade change in ionisation current is used. Differentiating this gives a current of 1.5 x 10-8 A for p.s.D. (20 sec. doubling time) in the differentiating amplifier. To overcome some of the problems of noise due to statistical variations in input current, the circuit design necessitates a resistive path to ground at the amplifier input of 20 M.ohms. A schematic diagram is shown. 1. It is evident that a zero drift of 1% can be caused by a leakage current of 1.5 x 10-10 A or an offset voltage of 3 mV at the amplifier input. Although the presently used electrometer valve is satisfactory from the point of view of grid current, there have been sudden changes in grid to grid voltage (the valve is a double triode) of up to 10 m.V. It has been found that a pair of F.E.T's. can be used to replace the electrometer valve so long as care is taken in correct balance of the two devices. An investigation has been made into the characteristics of some fourteen devices to see whether those with very different

  12. Candidate worldviews for design theory

    DEFF Research Database (Denmark)

    Galle, Per

    2008-01-01

    Our growing body of design theory risks being infected by more inconsistency than is justifiable by genuine disagreement among design theorists. Taking my cue from C. S. Peirce, who argued that theory inevitably rests on basic metaphysical assumptions that theorists ought to be critically aware of......, I demonstrate how ‘insidious inconsistency’ may infect design theory if we ignore his admonition. As a possible remedy, I propose a method by which the philosophy of design may develop sound metaphysical foundations (‘worldviews’) for design theory – and generate philosophical insights into design...... at the same time. Examples are given of how the first steps of the method may be carried out and a number of candidate worldviews are outlined and briefly discussed. In its own way, each worldview answers certain fundamental questions about the nature of design. These include the ontological question of what...

  13. Gender Differences on the Use of Amplifiers in Academic Writings

    Institute of Scientific and Technical Information of China (English)

    申利芬

    2012-01-01

      This study aims to investigate the use of amplifiers in term of gender and disciplinary groups in academic research arti⁃cles, which is based on the British Academic Written English Corpus (BAWE).18 amplifiers were examined across two dimen⁃sions:gender and disciplinary groups. The results show amplifiers are more common in males’ academic writings than in those of females in general, amplifiers are used more often in AH discipline. However, not all amplifiers show significant gender differ⁃ences between men and women. Six words show a significant difference between male and female writers:pretty, by far, perfect⁃ly, quite, a great deal, totally, which are used more often by males. However, the interesting is in LS discipline, most amplifiers are used more often by female than male writers and males tend to use by far more frequently than females.

  14. ANALYSIS OF INTERNALLY GENERATED NOISE OF BIOELECTRIC AMPLIFIERS

    Institute of Scientific and Technical Information of China (English)

    Mashhour Mustafa; Bani Amer

    2003-01-01

    This paper deals with internally generated noise of bioelectric amplifiers that are usually used for processing of bioelectric events. The main purpose of this paper is to present a procedure for analysis of the effects of internal noise generated by the active circuits and to evaluate the output noise of the author's new designed bioelectric amplifier that caused by internal effects to the amplifier circuit itself in order to compare it with the noise generated by conventional amplifiers. The obtained analysis results of internally generated noise showed that the total output noise of bioelectric active circuits does not increase when some of their resistors have a larger value. This behavior is caused by the different transfer functions for the signal and the respective noise sources associated with these resistors. Moreover, the new designed bioelectric amplifier has an output noise less than that for conventional amplifiers. The obtained analysis results were also experimentally verified and the final conclusions were drawn.

  15. Measurement of microdosimetric spectra using an amplifier with logarithmic response

    International Nuclear Information System (INIS)

    A 3-1/2 decade logarithmic pulse amplifier was developed for use in microdosimetry. A block diagram of the instrument is given. The input shaping amplifier is designed to accept output pulses from a charge sensitive preamplifier with a maximum full scale amplitude of 8 volts. Output of the shaping amplifier is a bipolar, positive lobe leading RC shaped pulse with a maximum linear range approximately 200 millivolts. Following the logarithmic converter is a voltage amplifier which is used to increase the signal level before it is applied through the linear gate to the output buffer-amplifier. The signal at the output connector is a positive pulse compatible with most conventional pulse height analyzers. The gain of the linear amplifier is adjustable over 10 to 1 range by means of front panel controls

  16. Josephson parametric amplifiers for the ADMX-HF experiment

    Science.gov (United States)

    Malnou, Maxime; Palken, Daniel; Hilton, Gene; Vale, Leila; Lehnert, Konrad

    2016-03-01

    Dark matter search in the ADMX-HF experiment aims at detecting power generated by the axion-photon conversion, of a few hundred of yoctowatts, in the 4 - 12 GHz band. The sensitivity of detection directly depends on the amplifier noise temperature, and therefore requires state of the art microwave amplifiers. In contrast to amplifiers with dissipation on-chip, superconducting Josephson parametric amplifiers (JPA) reach and even circumvent the quantum limit. Over the past years, we have developed JPAs fabricated with arrays of superconducting quantum interference devices. Their gain, bandwidth and tunability are particularly well suited for efficient amplification in the band of interest. In this talk we will present numerical modeling of the behavior of our amplifiers, along with the first results from new designs that cover the 4-12 GHz band. Finally, we will present the ongoing work to increase the gain-bandwidth product and gain stability of our amplifiers.

  17. Low-noise amplifiers for satellite communications

    Science.gov (United States)

    Whelehan, J.

    1984-02-01

    It is pointed out that over the past several years significant advances have been made in the overall capability of both microwave and mm-wave receivers. This is particularly apparent in the telecom market. Integral parts of advanced receiver technology are low-noise receivers. The advances currently being achieved in low-noise technology are partly based on developments in GaAs semiconductor technology. The development of high-cutoff-frequency beam lead mixer diodes has led to the development of mm-wave low-noise mixers with excellent low-noise capability. The advanced techniques are now being employed in field-deployable systems. Low noise is an important factor in satellite communications applications. Attention is given to C-band fixed satellite service, C-band parametric amplifiers, C-band FET, and X band, the Ku band, and the 30/20 GHz band.

  18. Gain Characteristics of Fiber Optical Parametric Amplifier

    Institute of Scientific and Technical Information of China (English)

    高明义; 姜淳; 胡卫生

    2004-01-01

    The theory model of fiber optical parametric amplifier (FOPA) was introduced, which is based on optical nonlinear effect. And then numerical simulation was done to analyze and discuss the gain spectral characteristics of one-pump and two-pump FOPA. The results show that for one-pump FOPA, when pump wavelength is near to fiber zero-dispersion wavelength(ZDW), the gain flatness is better, and with the increase of the pump power, fiber length and its nonlinear coefficient, the gain value will increase while the gain bandwidth will become narrow. For two-pump FOPA, when the pump central wavelength is near to fiber ZDW, the gain flatness is better. Moreover, by decreasing the space of two pumps wavelength, the gain flatness can be improved. Finally, some problems existing in FOPA were addressed.

  19. Development of nucleic acid vaccines: use of self-amplifying RNA in lipid nanoparticles

    Directory of Open Access Journals (Sweden)

    Rodríguez-Gascón A

    2014-04-01

    Full Text Available Alicia Rodríguez-Gascón, Ana del Pozo-Rodríguez, María Ángeles SolinísPharmacokinetic, Nanotechnology and Gene Therapy Group (PharmaNanoGene, Faculty of Pharmacy, Centro de Investigación Lascaray Ikergunea, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, SpainAbstract: Self-amplifying RNA or RNA replicon is a form of nucleic acid-based vaccine derived from either positive-strand or negative-strand RNA viruses. The gene sequences encoding structural proteins in these RNA viruses are replaced by mRNA encoding antigens of interest as well as by RNA polymerase for replication and transcription. This kind of vaccine has been successfully assayed with many different antigens as vaccines candidates, and has been shown to be potent in several animal species, including mice, nonhuman primates, and humans. A key challenge to realizing the broad potential of self-amplifying vaccines is the need for safe and effective delivery methods. Ideally, an RNA nanocarrier should provide protection from blood nucleases and extended blood circulation, which ultimately would increase the possibility of reaching the target tissue. The delivery system must then be internalized by the target cell and, upon receptor-mediated endocytosis, must be able to escape from the endosomal compartment into the cell cytoplasm, where the RNA machinery is located, while avoiding degradation by lysosomal enzymes. Further, delivery systems for systemic administration ought to be well tolerated upon administration. They should be safe, enabling the multiadministration treatment modalities required for improved clinical outcomes and, from a developmental point of view, production of large batches with reproducible specifications is also desirable. In this review, the concept of self-amplifying RNA vaccines and the most promising lipid-based delivery systems are discussed.Keywords: self-amplifying RNA vaccine, RNA replicon, liposomes, solid lipid nanoparticles, nucleic acid

  20. The spectacular human nose: An amplifier of individual quality?

    OpenAIRE

    Åse Kristine Rognmo Mikalsen; Ivar Folstad; Nigel Gilles Yoccoz; Bruno Laeng

    2014-01-01

    Amplifiers are signals that improve the perception of underlying differences in quality. They are cost free and advantageous to high quality individuals, but disadvantageous to low quality individuals, as poor quality is easier perceived because of the amplifier. For an amplifier to evolve, the average fitness benefit to the high quality individuals should be higher than the average cost for the low quality individuals. The human nose is, compared to the nose of most other primates, extraordi...

  1. Thermodynamic indistinguishability and field state fingerprint of quantum optical amplifiers

    OpenAIRE

    Perl, Yossi; Band, Yehuda B.; Boukobza, Erez

    2016-01-01

    Dissipation tends to wash out dynamical features observed at early evolution times. In this paper we analyze a resonant single--atom two--photon quantum optical amplifier both dynamically and thermodynamically. A detailed thermodynamic balance shows that the non--linear amplifier is thermodynamically equivalent to the linear amplifier discussed in (Phys. Rev. A, 74 (2006), 063822). However, by calculating the Wigner quasi--probability distribution for various initial field states, we show tha...

  2. Modeling and design techniques for RF power amplifiers

    CERN Document Server

    Raghavan, Arvind; Laskar, Joy

    2008-01-01

    The book covers RF power amplifier design, from device and modeling considerations to advanced circuit design architectures and techniques. It focuses on recent developments and advanced topics in this area, including numerous practical designs to back the theoretical considerations. It presents the challenges in designing power amplifiers in silicon and helps the reader improve the efficiency of linear power amplifiers, and design more accurate compact device models, with faster extraction routines, to create cost effective and reliable circuits.

  3. A high performance switching audio amplifier using sliding mode control

    OpenAIRE

    Pillonnet, Gael; Cellier, Rémy; Abouchi, Nacer; Chiollaz, Monique

    2008-01-01

    International audience The switching audio amplifiers are widely used in various portable and consumer electronics due to their high efficiency, but suffers from low audio performances due to inherent nonlinearity. This paper presents an integrated class D audio amplifier with low consumption and high audio performances. It includes a power stage and an efficient control based on sliding mode technique. This monolithic class D amplifier is capable of delivering up to 1W into 8Ω load at les...

  4. Saturation effects in degenerate phase sensitive fiber optic parametric amplifiers

    OpenAIRE

    Kakande J.; Parmigiani F.; Slavik R.; Gruner-Nielsen L.; Jakobsen D.; Herstrom S.; Petropoulos P.; Richardson D.J.

    2010-01-01

    We experimentally study saturation effects in degenerate phase sensitive amplifiers, revealing and explaining a gain regime suitable for all-optical signal processing functions such as phase regeneration.

  5. Parametric Amplifiers for Microwave Kinectic Inductance Detector (MKID) Readout Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Find numerical solutions to the non-linear partial differential equations describing our amplifier transmission lines. Optimize periodic choke structure to block...

  6. Dual Band High Efficiency Power Amplifier Based on CRLH Lines

    Directory of Open Access Journals (Sweden)

    D. Segovia-Vargas

    2009-12-01

    Full Text Available In this paper we propose the use of Composite Right/Left Hand (CRLH and Extended Composite Right/Left Hand (ECRLH transmission lines for the design of dual band high efficiency power amplifiers working in CE class. The harmonic termination can be synthesized using the meta-lines is particularly suitable for CE class amplifiers, which have a termination not as sensitive to the third harmonic as F class amplifier. This paper presents the design procedure and the design equations. The nonlinear phase response of a CRLH and ECRLH transmission line has been utilized to design arbitrary dual-band amplifiers.

  7. Nylon Sleeve for Cavity Amplifier Holds Tuning Despite Heat

    Science.gov (United States)

    Derr, Lloyd

    1964-01-01

    The problem: Detuning of cavity amplifiers with change in temperature. This results in deterioration of the performance of the amplifier at its design frequency. In cavity amplifiers and filters it is desirable that constant performance be maintained regardless of thermal changes. These changes often cause an "off resonance shift" in a cavity filter and a deterioration of performance in a cavity amplifier. The solution: Mount the tuning probe in a nylon sleeve. Thermal expansion and contraction of the nylon nullifies unwanted capacitive and inductive changes in the resonant elements.

  8. Compensation of pulse-distortion in saturated laser amplifiers.

    Science.gov (United States)

    Schimpf, Damian N; Ruchert, Clemens; Nodop, Dirk; Limpert, Jens; Tünnermann, Andreas; Salin, Francois

    2008-10-27

    We derive an expression describing pre-compensation of pulse-distortion due to saturation effects in short pulse laser-amplifiers. The analytical solution determines the optimum input pulse-shape required to obtain any arbitrary target pulse-shape at the output of the saturated laser-amplifier. The relation is experimentally verified using an all-fiber amplifier chain that is seeded by a directly modulated laser-diode. The method will prove useful in applications of high power, high energy laser-amplifier systems that need particular pulse-shapes to be efficient, e.g. micromachining and scientific laser-matter-interactions. PMID:18958044

  9. Scaffold State Switching Amplifies, Accelerates, and Insulates Protein Kinase C Signaling*

    Science.gov (United States)

    Greenwald, Eric C.; Redden, John M.; Dodge-Kafka, Kimberly L.; Saucerman, Jeffrey J.

    2014-01-01

    Scaffold proteins localize two or more signaling enzymes in close proximity to their downstream effectors. A-kinase-anchoring proteins (AKAPs) are a canonical family of scaffold proteins known to bind protein kinase A (PKA) and other enzymes. Several AKAPs have been shown to accelerate, amplify, and specify signal transduction to dynamically regulate numerous cellular processes. However, there is little theory available to mechanistically explain how signaling on protein scaffolds differs from solution biochemistry. In our present study, we propose a novel kinetic mechanism for enzymatic reactions on protein scaffolds to explain these phenomena, wherein the enzyme-substrate-scaffold complex undergoes stochastic state switching to reach an active state. This model predicted anchored enzymatic reactions to be accelerated, amplified, and insulated from inhibition compared with those occurring in solution. We exploited a direct interaction between protein kinase C (PKC) and AKAP7α as a model to validate these predictions experimentally. Using a genetically encoded PKC activity reporter, we found that both the strength and speed of substrate phosphorylation were enhanced by AKAP7α. PKC tethered to AKAP7α was less susceptible to inhibition from the ATP-competitive inhibitor Gö6976 and the substrate-competitive inhibitor PKC 20-28, but not the activation-competitive inhibitor calphostin C. Model predictions and experimental validation demonstrated that insulation is a general property of scaffold tethering. Sensitivity analysis indicated that these findings may be applicable to many other scaffolds as well. Collectively, our findings provide theoretical and experimental evidence that scaffold proteins can amplify, accelerate, and insulate signal transduction. PMID:24302730

  10. Electron acceleration at nearly perpendicular collisionless shocks. 3: Downstream distributions

    Science.gov (United States)

    Krauss-Varban, D.

    1994-01-01

    Spacecraft observations at the Earth's bow shock and at interplanetary shocks have established that the largest fluxes of accelerated suprathermal electrons occur in so-called shock spike events immediately downstream of the shock ramp. Previous theoretical efforts have mainly focused on explaining upstream energetic electron beams. Here we investigate the general motion and acceleration of energetic electrons in a curved, nearly perpendicular shock by numerically integrating the orbits of solar wind halo electrons in shock fields generated by a hybrid simulation (core electron fluid and kinetic ions). Close to the angle Theta(sub Bn) = 90 degs between the upstream magnetic field and shock normal, the calculations result in a (perpendicular) temperature increase proportional to the magnetic field ratio and give the highest phase space densities in the overshoot. For a steep distribution, the temperature change can correspond to an enhancement of the distribution by several orders of magnitude. These results are in agreement with predictions from adiabatic mapping. With smaller angles Theta(sub Bn), the overshoot and downstream densities fall off quickly, because the adiabatic energy gain is less and fewer electrons transmit. The shock curvature also leads to an accumulation of electrons close to 90 degs. Without pitch angle scattering, energization is only significant within a few (approximately 5 to 10 degs) degrees of the point of tangency. However, shock spike events appear to be observed more easily and farther away from 90 degs. Given that over a region of several degrees around 90 degs the theory gives enhancements of up to approximately 4 orders of magnitude, such electrons could in principle account for the typically observed enhancements of 1 to 2 orders of magnitude, if they were distributed over Theta(sub Bn). To test the idea that scattering could efficiently redistribute the energetic electrons, we have conducted test particle simulations in which

  11. Corrosion impact of reductant on DWPF and downstream facilities

    Energy Technology Data Exchange (ETDEWEB)

    Mickalonis, J. I. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Imrich, K. J. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Jantzen, C. M. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Murphy, T. H. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Wilderman, J. E. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2014-12-01

    Glycolic acid is being evaluated as an alternate reductant in the preparation of high level waste for the Defense Waste Processing Facility (DWPF) at the Savannah River Site (SRS). During processing, the glycolic acid is not completely consumed and small quantities of the glycolate anion are carried forward to other high level waste (HLW) facilities. The impact of the glycolate anion on the corrosion of the materials of construction throughout the waste processing system has not been previously evaluated. A literature review had revealed that corrosion data in glycolate-bearing solution applicable to SRS systems were not available. Therefore, testing was recommended to evaluate the materials of construction of vessels, piping and components within DWPF and downstream facilities. The testing, conducted in non-radioactive simulants, consisted of both accelerated tests (electrochemical and hot-wall) with coupons in laboratory vessels and prototypical tests with coupons immersed in scale-up and mock-up test systems. Eight waste or process streams were identified in which the glycolate anion might impact the performance of the materials of construction. These streams were 70% glycolic acid (DWPF feed vessels and piping), SRAT/SME supernate (Chemical Processing Cell (CPC) vessels and piping), DWPF acidic recycle (DWPF condenser and recycle tanks and piping), basic concentrated recycle (HLW tanks, evaporators, and transfer lines), salt processing (ARP, MCU, and Saltstone tanks and piping), boric acid (MCU separators), and dilute waste (HLW evaporator condensate tanks and transfer line and ETF components). For each stream, high temperature limits and worst-case glycolate concentrations were identified for performing the recommended tests. Test solution chemistries were generally based on analytical results of actual waste samples taken from the various process facilities or of prototypical simulants produced in the laboratory. The materials of construction for most vessels

  12. Extreme High and Low Temperature Operation of the Silicon-On-Insulator Type CHT-OPA Operational Amplifier

    Science.gov (United States)

    Patterson, Richard; Hammoud, Ahmad; Elbuluk, Malik

    2008-01-01

    A new operational amplifier chip based on silicon-on-insulator technology was evaluated for potential use in extreme temperature environments. The CHT-OPA device is a low power, precision operational amplifier with rail-to-rail output swing capability, and it is rated for operation between -55 C and +225 C. A unity gain inverting circuit was constructed utilizing the CHT-OPA chip and a few passive components. The circuit was evaluated in the temperature range from -190 C to +200 C in terms of signal gain and phase shift, and supply current. The investigations were carried out to determine suitability of this device for use in space exploration missions and aeronautic applications under wide temperature incursion. Re-restart capability at extreme temperatures, i.e. power switched on while the device was soaked at extreme temperatures, was also investigated. In addition, the effects of thermal cycling under a wide temperature range on the operation of this high performance amplifier were determined. The results from this work indicate that this silicon-on-insulator amplifier chip maintained very good operation between +200 C and -190 C. The limited thermal cycling had no effect on the performance of the amplifier, and it was able to re-start at both -190 C and +200 C. In addition, no physical degradation or packaging damage was introduced due to either extreme temperature exposure or thermal cycling. The good performance demonstrated by this silicon-on-insulator operational amplifier renders it a potential candidate for use in space exploration missions or other environments under extreme temperatures. Additional and more comprehensive characterization is, however, required to establish the reliability and suitability of such devices for long term use in extreme temperature applications.

  13. Simulation of hanging dams downstream of Ossauskoski power plant

    Energy Technology Data Exchange (ETDEWEB)

    Aaltonen, J.; Huokuna, M. [Finnish Environment Inst., Helsinki (Finland); Severinkangas, K.; Talvensaari, M. [Kemijoki Oy, Rovaniemi (Finland)

    2008-07-01

    Sixteen power plants have been constructed along Finland's Kemijoki River for hydroelectric power production. The Ossauskoski facility has recently undergone major renovations and upgrade, making it the sixth largest hydroelectric power plant in Finland, with a new capacity of 124 MW and an annual energy output of 501 GWh. The increase in power output and discharge may cause changes in ice conditions downstream of the power plant. The section of the river is already subjected to frazil ice problems and hanging dam formation. Discharges and adverse effects of frazil ice phenomena are likely to increase due to climate change, resulting in harm for hydropower production and the environment, particularly in flow regulated rivers where winter discharges are higher than natural discharges. As such, a study was launched to investigate a dredge plan suggested by by the electric utility Kemijoki Oy. The project involved mapping the river bed topography to identify the location and extent of hanging dams. A sounding device and ground penetrating radar was used to find the thaw regions in the ice cover. The JJT numerical river ice model was effectively used to study the effect of hanging dams on water levels. However, the ice bridging phenomena was not modelled in a reliable way by the JJT model and will be modelled in the future using the CRISSP2D numerical model. 5 refs., 11 figs.

  14. Expression pattern of GASA, downstream genes of DELLA, in Arabidopsis

    Institute of Scientific and Technical Information of China (English)

    ZHANG ShengChun; WANG XiaoJing

    2008-01-01

    Separation and functional research of related components involved in gibberellins (GAs) signaling are important to clarify the mechanism of GA functioning. Research on the downstream components of DELLA, the key factor of the GA signaling pathway, is limited at present. GASA (GA-Stimulated in Arabidopsis) family contains 15 genes usually regulated by GA in Arabidopsis thaliana. All GASA proteins have a cleavable signal peptide in N terminus and a conserved GASA domain including 12 cysteines in C terminus. RT-PCR analysis revealed that the expression of GASA4 and GASA6 were down-regulated, but GASA1 and GASA9were up-regulated in the DELLA mutants, gai-t6 and rga-24, as well as the double mutant, consisting with the results that GASA4 and GASA6 were induced, but GASA1 and GASA9 were inhibited by exogenous GA3. In addition, the expression patterns of other GASA genes were regulated by GA and ABA, separately or cooperatively. Most of GASA genes were expressed in roots, stems, leaves, flowers and developing siliques. GUS gene driven by the promoters of GASA6, GASA7, GASAS, GASA9, GASA10, GASA11 and GASA12were used as reporters and it was found that all GASA genes expressed in the growing and differentiating organs and abscission zones,suggesting the role of these genes in cell growth and differentiation. This study provided an important basis for functional study of the GASA gene family in the GA and ABA signaling pathway.

  15. Downstream effects of a hydroelectric reservoir on aquatic plant assemblages.

    Science.gov (United States)

    Bernez, Ivan; Haury, Jacques; Ferreira, Maria Teresa

    2002-03-16

    Macrophytes were studied downstream of the Rophémel hydroelectric dam on the River Rance (Côtes d'Armor Department, western France) to assess the effects of hydroelectric functioning on river macrophyte communities. We studied ten representative sections of the hydro-peaking channel on five occasions in 1995 and 1996, on a 15-km stretch of river. Floristic surveys were carried out on sections 50 m in length, and genera of macroalgae, species of bryophyta, hydrophytes, and emergent rhizophytes were identified. For the aquatic bryophytes and spermatophytes section of our study, we compared our results with 19th century floristic surveys, before the dam was built. During the vegetative growth period, the hydro-peaking frequency was low. The plant richness was highest near the dam. The macrophyte communities were highly modified according to the distance to the dam. The frequency and magnitude of hydro-peaking was related to the aquatic macrophyte richness in an Intermediate Disturbance Hypothesis position. However, the results of the eco-historical comparison with 19th century floristic surveys point to the original nature of the flora found at the site. Some floral patterns, seen during both periods and at an interval of 133 years, were indicative of the ubiquity of the aquatic flora and of the plants" adaptability. This demonstrates the importance of taking river basin history into account in such biological surveys.

  16. Downstream Effects of a Hydroelectric Reservoir on Aquatic Plant Assemblages

    Directory of Open Access Journals (Sweden)

    Ivan Bernez

    2002-01-01

    Full Text Available Macrophytes were studied downstream of the Rophémel hydroelectric dam on the River Rance (Côtes d’Armor Department, western France to assess the effects of hydroelectric functioning on river macrophyte communities. We studied ten representative sections of the hydro-peaking channel on five occasions in 1995 and 1996, on a 15-km stretch of river. Floristic surveys were carried out on sections 50 m in length, and genera of macroalgae, species of bryophyta, hydrophytes, and emergent rhizophytes were identified. For the aquatic bryophytes and spermatophytes section of our study, we compared our results with 19th century floristic surveys, before the dam was built. During the vegetative growth period, the hydro-peaking frequency was low. The plant richness was highest near the dam. The macrophyte communities were highly modified according to the distance to the dam. The frequency and magnitude of hydro-peaking was related to the aquatic macrophyte richness in an Intermediate Disturbance Hypothesis position. However, the results of the eco-historical comparison with 19th century floristic surveys point to the original nature of the flora found at the site. Some floral patterns, seen during both periods and at an interval of 133 years, were indicative of the ubiquity of the aquatic flora and of the plants’ adaptability. This demonstrates the importance of taking river basin history into account in such biological surveys.

  17. Non-Uniform Sediment Transport Downstream from Reservoir

    Institute of Scientific and Technical Information of China (English)

    LI Yitian; CHEN Fei

    2008-01-01

    The transport characters of non-uniform sediment before and after the reservoir operation are compared and analyzed. Field data from the Three Gorges Reservoir (TGR), Danjiangkou, and Sanmenxia reservoir indicate that the transport character of coarse particle is various in different reaches. Before the reservoir operation, the dramatic decrease of the hydraulic condition in some reaches is the main reason to cause the coarse particle deposited. After the reservoir operation,almost all grain sized sediment may be eroded, when the reach is eroded seriously. However, the transport character of the coarse particle will be consistent with what it was before, when the reach is not eroded seriously. The deposition amount will be less than its pre-dam value, and it will tend to decrease with the time going on. Erosion of fine particle results from its unsaturation. Long-distance erosion downstream from reservoir is caused by shortage of the supply from riverbed, es-pecially the shortage of fine particle.

  18. Hydroeconomic optimization of reservoir management under downstream water quality constraints

    Science.gov (United States)

    Davidsen, Claus; Liu, Suxia; Mo, Xingguo; Holm, Peter E.; Trapp, Stefan; Rosbjerg, Dan; Bauer-Gottwein, Peter

    2015-10-01

    A hydroeconomic optimization approach is used to guide water management in a Chinese river basin with the objectives of meeting water quantity and water quality constraints, in line with the China 2011 No. 1 Policy Document and 2015 Ten-point Water Plan. The proposed modeling framework couples water quantity and water quality management and minimizes the total costs over a planning period assuming stochastic future runoff. The outcome includes cost-optimal reservoir releases, groundwater pumping, water allocation, wastewater treatments and water curtailments. The optimization model uses a variant of stochastic dynamic programming known as the water value method. Nonlinearity arising from the water quality constraints is handled with an effective hybrid method combining genetic algorithms and linear programming. Untreated pollutant loads are represented by biochemical oxygen demand (BOD), and the resulting minimum dissolved oxygen (DO) concentration is computed with the Streeter-Phelps equation and constrained to match Chinese water quality targets. The baseline water scarcity and operational costs are estimated to 15.6 billion CNY/year. Compliance to water quality grade III causes a relatively low increase to 16.4 billion CNY/year. Dilution plays an important role and increases the share of surface water allocations to users situated furthest downstream in the system. The modeling framework generates decision rules that result in the economically efficient strategy for complying with both water quantity and water quality constraints.

  19. X-Band, 17-Watt Solid-State Power Amplifier

    Science.gov (United States)

    Mittskus, Anthony; Stone, Ernest; Boger, William; Burgess, David; Honda, Richard; Nuckolls, Carl

    2005-01-01

    An advanced solid-state power amplifier that can generate an output power of as much as 17 W at a design operating frequency of 8.4 GHz has been designed and constructed as a smaller, lighter, less expensive alternative to traveling-wave-tube X-band amplifiers and to prior solid-state X-band power amplifiers of equivalent output power. This amplifier comprises a monolithic microwave integrated circuit (MMIC) amplifier module and a power-converter module integrated into a compact package (see Figure 1). The amplifier module contains an input variable-gain amplifier (VGA), an intermediate driver stage, a final power stage, and input and output power monitors (see Figure 2). The VGA and the driver amplifier are 0.5-m GaAs-based metal semiconductor field-effect transistors (MESFETs). The final power stage contains four parallel high-efficiency, GaAs-based pseudomorphic high-electron-mobility transistors (PHEMTs). The gain of the VGA is voltage-variable over a range of 10 to 24 dB. To provide for temperature compensation of the overall amplifier gain, the gain-control voltage is generated by an operational-amplifier circuit that includes a resistor/thermistor temperature-sensing network. The driver amplifier provides a gain of 14 dB to an output power of 27 dBm to drive the four parallel output PHEMTs, each of which is nominally capable of putting out as much as 5 W. The driver output is sent to the input terminals of the four parallel PHEMTs through microstrip power dividers; the outputs of these PHEMTs are combined by microstrip power combiners (which are similar to the microstrip power dividers) to obtain the final output power of 17 W.

  20. Ferroelectric Field-Effect Transistor Differential Amplifier Circuit Analysis

    Science.gov (United States)

    Phillips, Thomas A.; MacLeod, Todd C.; Ho, Fat D.

    2008-01-01

    There has been considerable research investigating the Ferroelectric Field-Effect Transistor (FeFET) in memory circuits. However, very little research has been performed in applying the FeFET to analog circuits. This paper investigates the use of FeFETs in a common analog circuit, the differential amplifier. The two input Metal-Oxide-Semiconductor (MOS) transistors in a general MOS differential amplifier circuit are replaced with FeFETs. Resistors are used in place of the other three MOS transistors. The FeFET model used in the analysis has been previously reported and was based on experimental device data. Because of the FeFET hysteresis, the FeFET differential amplifier has four different operating modes depending on whether the FeFETs are positively or negatively polarized. The FeFET differential amplifier operation in the different modes was analyzed by calculating the amplifier voltage transfer and gain characteristics shown in figures 2 through 5. Comparisons were made between the FeFET differential amplifier and the standard MOS differential amplifier. Possible applications and benefits of the FeFET differential amplifier are discussed.

  1. Phase Sensitive Amplifier Based on Ultrashort Pump Pulses

    CERN Document Server

    Gershikov, Alexander

    2016-01-01

    We demonstrate a narrow band phase sensitive amplifier in the pump degenerate configuration which employs ps pump pulses. Control of the amplifier bandwidth is achieved via changes of the pump spectral width. A phase sensitive gain between -6 and 6 decibels, with an overall system gain of 28dB was demonstrated.

  2. Externally pumped millimeter-wave Josephson-junction parametric amplifier

    DEFF Research Database (Denmark)

    Levinsen, M.T; Pedersen, Niels Falsig; Sørensen, Ole;

    1980-01-01

    A unified theory of the singly and doubly degenerate Josephson-junction parametric amplifier is presented. Experiments with single junctions on both amplifier modes at frequencies 10, 35, and 70 GHz are discussed. Low-noise temperature (∼100 K, single sideband (SSB)) and reasonable gain (∼8 dB) w...

  3. Efficient performance simulation of class D amplifier output stages

    DEFF Research Database (Denmark)

    Nyboe, Flemming; Risbo, Lars; Andreani, Pietro

    2005-01-01

    Straightforward simulation of amplifier distortion involves transient simulation of operation on a sine wave input signal, and a subsequent FFT of the output voltage. This approach is very slow on class D amplifiers, since the switching behavior forces simulation time steps that are many orders...

  4. Saturation and noise properties of quantum-dot optical amplifiers

    DEFF Research Database (Denmark)

    Berg, Tommy Winther; Mørk, Jesper

    2004-01-01

    Based on extensive numerical calculations, quantum-dot (QD) amplifiers are predicted to offer higher output power and lower noise figure compared to bulk as well as quantum well amplifiers. The underlying physical mechanisms are analyzed in detail, leading to the identification of a few key requi...

  5. Subjective test of class D amplifiers without output filter

    DEFF Research Database (Denmark)

    Agerkvist, Finn T.; Fenger, Lars M.

    2004-01-01

    This paper presents the results of subjective listening tests designed to determine whether the output filter on class D amplifiers used in active loudspeakers can be omitted without audible errors occurring. The frequency range of the amplifiers was limited to 0-3 kHz corresponding to a woofer...

  6. External Peltier Cooler For Low-Noise Amplifier

    Science.gov (United States)

    Soper, Terry A.

    1990-01-01

    Inexpensive Peltier-effect cooling module made of few commercially available parts used to reduce thermal noise in microwave amplifier. Retrofitted to almost any microwave low-noise amplifier or receiver preamplifier used in communication, telemetry, or radar. Includes copper or aluminum cold plate held tightly against unit to be cooled by strap-type worm-gear clamps.

  7. Design and Analysis of Hybrid CMOS SRAM Sense Amplifier

    Directory of Open Access Journals (Sweden)

    Karishma Bajaj

    2012-03-01

    Full Text Available Sense amplifiers are one of the very important peripheral components of CMOS memories. In a Hybrid Sense amplifier both current and voltage sensing techniques are used which makes it a better selection than a conventional current or voltage sense amplifiers. The hybrid sense amplifier works in three phases-Offset cancellation (200ps, Access phase (500ps and Evaluation phase. The offset cancellation is done simultaneously with word line decoding, so as to speed up the process. The sensing range of the hybrid sense amplifier is improved from 1.18mV to 92mV. Also hybrid sense amplifier consumes very low energy of about 6.84fj. This sense amplifier is analyzed with a column of 512 SRAM cells at 180nm technology node and compared to CMOS conventional voltage sense amplifier. The circuit consumes an average power of 1.57 µW with a negligible offset of 149.3µV.

  8. Gain characteristics of a saturated fiber optic parametric amplifier

    DEFF Research Database (Denmark)

    Rottwitt, Karsten; Lorenzen, Michael Rodas; Noordegraaf, Danny;

    2008-01-01

    In this work we discuss saturation performance of a fiber optic parametric amplifier. A simple numerical model is described and applied to specific cases. A system experiment using a saturated amplifier illustrates a 4 dB improvement in required signal to noise ratio for a fixed bit error ratio....

  9. Power Amplifier Design for E-band Wireless System Communications

    DEFF Research Database (Denmark)

    Hadziabdic, Dzenan; Krozer, Viktor; Johansen, Tom Keinicke

    2008-01-01

    a power amplifier design satisfying the E-band system specifications. The designed power amplifier achieves a maximum output power of ges 20 dBm with a state-of-the-art power-added efficiency of 15%. The power is realized using InP DHBT technology. To the best of our knowledge it is the highest output...

  10. Series-Tuned High Efficiency RF-Power Amplifiers

    DEFF Research Database (Denmark)

    Vidkjær, Jens

    2008-01-01

    An approach to high efficiency RF-power amplifier design is presented. It addresses simultaneously efficiency optimization and peak voltage limitations when transistors are pushed towards their power limits.......An approach to high efficiency RF-power amplifier design is presented. It addresses simultaneously efficiency optimization and peak voltage limitations when transistors are pushed towards their power limits....

  11. Optically amplifying planar glass waveguides: Laser on a chip

    DEFF Research Database (Denmark)

    Guldberg-Kjær, Søren Andreas

    The objective of this work was to devlop optically amplifying planar wavguides, using erbium-doped germano-silicate glass films deposited by PECVD (Plasma Enhanced Chemical Vapour Deposition). The waveguides should exhibit enough gain to be useful as optical amplifiers in integrated planar lightw...

  12. Implantable neurotechnologies: a review of integrated circuit neural amplifiers.

    Science.gov (United States)

    Ng, Kian Ann; Greenwald, Elliot; Xu, Yong Ping; Thakor, Nitish V

    2016-01-01

    Neural signal recording is critical in modern day neuroscience research and emerging neural prosthesis programs. Neural recording requires the use of precise, low-noise amplifier systems to acquire and condition the weak neural signals that are transduced through electrode interfaces. Neural amplifiers and amplifier-based systems are available commercially or can be designed in-house and fabricated using integrated circuit (IC) technologies, resulting in very large-scale integration or application-specific integrated circuit solutions. IC-based neural amplifiers are now used to acquire untethered/portable neural recordings, as they meet the requirements of a miniaturized form factor, light weight and low power consumption. Furthermore, such miniaturized and low-power IC neural amplifiers are now being used in emerging implantable neural prosthesis technologies. This review focuses on neural amplifier-based devices and is presented in two interrelated parts. First, neural signal recording is reviewed, and practical challenges are highlighted. Current amplifier designs with increased functionality and performance and without penalties in chip size and power are featured. Second, applications of IC-based neural amplifiers in basic science experiments (e.g., cortical studies using animal models), neural prostheses (e.g., brain/nerve machine interfaces) and treatment of neuronal diseases (e.g., DBS for treatment of epilepsy) are highlighted. The review concludes with future outlooks of this technology and important challenges with regard to neural signal amplification.

  13. Frequency-Offset Cartesian Feedback Based on Polyphase Difference Amplifiers

    OpenAIRE

    Zanchi, Marta G.; Pauly, John M.; Scott, Greig C

    2010-01-01

    A modified Cartesian feedback method called “frequency-offset Cartesian feedback” and based on polyphase difference amplifiers is described that significantly reduces the problems associated with quadrature errors and DC-offsets in classic Cartesian feedback power amplifier control systems.

  14. Switching-mode Audio Power Amplifiers with Direct Energy Conversion

    DEFF Research Database (Denmark)

    Ljusev, Petar; Andersen, Michael Andreas E.

    2005-01-01

    This paper presents a new class of switching-mode audio power amplifiers, which are capable of direct energy conversion from the AC mains to the audio output. They represent an ultimate integration of a switching-mode power supply and a Class D audio power amplifier, where the intermediate DC bus...

  15. Ultrafast Dynamics of Quantum-Dot Semiconductor Optical Amplifiers

    DEFF Research Database (Denmark)

    Poel, Mike van der; Hvam, Jørn Märcher

    2007-01-01

    We report on a series of experiments on the dynamical properties of quantum-dot semiconductor optical amplifiers. We show how the amplifier responds to one or several ultrafast (170 fs) pulses in rapid succession and our results demonstrate applicability and ultimate limitations to application...

  16. Variable-Voltage Class-E Power Amplifiers

    NARCIS (Netherlands)

    Acar, Mustafa; Annema, Anne Johan; Nauta, Bram

    2007-01-01

    The Class-E power amplifier is widely used due to its high efficiency, resulting from switching at zero voltage and zero slope of the switch voltage. In this paper, we extend general analytical solutions for the Class-E power amplifier to the ideal single-ended Variable-Voltage Class-E (Class-EVV) p

  17. Optimisation of High-Power Amplifiers using non linear models

    NARCIS (Netherlands)

    Hek, A.P. de; Bogaart, F.L.M. van den

    1999-01-01

    This paper identifies the areas where the use of non-linear simulations for the design of high-power amplifiers is useful. The identified areas are: operating class selection, determination source and load impedance for matching network design, overall amplifier simulations and stability analysis un

  18. A Power Efficient Audio Amplifier Combining Switching and Linear Techniques

    NARCIS (Netherlands)

    Zee, van der R.A.R.; Tuijl, van A.J.M.

    1998-01-01

    Integrated Class D audio amplifiers are very power efficient, but require an external filter which prevents further integration. Also due to this filter, large feedback factors are hard to realise, so that the load influences the distortion- and transfer characteristics. The amplifier presented in t

  19. An RF Power Amplifier in a Digital CMOS Process

    DEFF Research Database (Denmark)

    Nielsen, Per Asbeck; Fallesen, Carsten

    2002-01-01

    A two stage class B power amplifier for 1.9 GHz is presented. The amplifier is fabricated in a standard digital EPI-CMOS process with low resistivity substrate. The measured output power is 29 dBm in a 50 Omega load. A design method to find the large signal parameters of the output transistor...

  20. Models of reduced-noise, probabilistic linear amplifiers

    Science.gov (United States)

    Combes, Joshua; Walk, Nathan; Lund, A. P.; Ralph, T. C.; Caves, Carlton M.

    2016-05-01

    We construct an amplifier that interpolates between a nondeterministic, immaculate linear amplifier and a deterministic, ideal linear amplifier and beyond to nonideal linear amplifiers. The construction involves cascading an immaculate linear amplifier that has amplitude gain g1 with a (possibly) nonideal linear amplifier that has gain g2. With respect to normally ordered moments, the device has output noise μ2(G2-1 ) where G =g1g2 is the overall amplitude gain and μ2 is a noise parameter. When μ2≥1 , our devices realize ideal (μ2=1 ) and nonideal (μ2>1 ) linear amplifiers. When 0 ≤μ2devices work effectively only over a restricted region of phase space and with some subunity success probability p✓. We investigate the performance of our μ2 amplifiers in terms of a gain-corrected probability-fidelity product and the ratio of input to output signal-to-noise ratios corrected for success probability.

  1. Advances in Solid Core Photonic Bandgap Fiber Amplifiers

    DEFF Research Database (Denmark)

    Alkeskjold, Thomas Tanggaard; Laurila, Marko; Petersen, Sidsel Rübner;

    2012-01-01

    We present recent development of photonic crystal fiber amplifiers containing photonic bandgap structures for enhanced spectral and modal filtering functionality.......We present recent development of photonic crystal fiber amplifiers containing photonic bandgap structures for enhanced spectral and modal filtering functionality....

  2. Amplifying Islam : Pluralism, Secularism, and Religious Sounds in The Netherlands

    NARCIS (Netherlands)

    Tamimi Arab, P.

    2015-01-01

    This dissertation is an ethnographic study of the amplified azan, the Islamic call to prayer, in the Netherlands, adding a sonic dimension to analyses of the politics of Islamic aesthetics in the western world. Often rejected by opponents as noise pollution, facilitating the amplified azan is an exa

  3. PHEMT Distributed Power Amplifier Adopting Broadband Impedance Transformer

    DEFF Research Database (Denmark)

    Narendra, K.; Limiti, E.; Paoloni, C.;

    2013-01-01

    A non-uniform drain line distributed power amplifier (DPA) employing a broadband impedance transformer is presented. The DPA is based on GaAs PHEMT technology. The impedance transformer employs asymmetric coupled lines and transforms a low output impedance of the amplifier to a standard 50 Ω...

  4. Cardiac evaluation of liver transplant candidates

    OpenAIRE

    Mandell, Mercedes Susan; Lindenfeld, JoAnn; Tsou, Mei-Yung; Zimmerman, Michael

    2008-01-01

    Physicians previously thought that heart disease was rare in patients with end stage liver disease. However, recent evidence shows that the prevalence of ischemic heart disease and cardiomyopathy is increased in transplant candidates compared to most other surgical candidates. Investigators estimate that up to 26% of all liver transplant candidates have at least one critical coronary artery stenosis and that at least half of these patients will die perioperatively of cardiac complications. Ca...

  5. Newly identified YSO candidates towards LDN 1188

    Science.gov (United States)

    Marton , G.; Verebélyi, E.; Kiss, Cs.; Smidla, J.

    2013-11-01

    We present an analysis of young stellar object (YSO) candidates towards the LDN 1188 molecular cloud. The YSO candidates were selected from the WISE all-sky catalogue, based on a statistical method. We found 601 candidates in the region, and classified them as Class I, Flat, and Class II YSOs. Groups were identified and described with the Minimal Spanning Tree (MST) method. Previously identified molecular cores show evidence of ongoing star formation at different stages throughout the cloud complex.

  6. Wind-Driven Ecological Flow Regimes Downstream from Hydropower Dams

    Science.gov (United States)

    Kern, J.; Characklis, G. W.

    2012-12-01

    Conventional hydropower can be turned on and off quicker and less expensively than thermal generation (coal, nuclear, or natural gas). These advantages enable hydropower utilities to respond to rapid fluctuations in energy supply and demand. More recently, a growing renewable energy sector has underlined the need for flexible generation capacity that can complement intermittent renewable resources such as wind power. While wind power entails lower variable costs than other types of generation, incorporating it into electric power systems can be problematic. Due to variable and unpredictable wind speeds, wind power is difficult to schedule and must be used when available. As a result, integrating large amounts of wind power into the grid may result in atypical, swiftly changing demand patterns for other forms of generation, placing a premium on sources that can be rapidly ramped up and down. Moreover, uncertainty in wind power forecasts will stipulate increased levels of 'reserve' generation capacity that can respond quickly if real-time wind supply is less than expected. These changes could create new hourly price dynamics for energy and reserves, altering the short-term financial signals that hydroelectric dam operators use to schedule water releases. Traditionally, hourly stream flow patterns below hydropower dams have corresponded in a very predictable manner to electricity demand, whose primary factors are weather (hourly temperature) and economic activity (workday hours). Wind power integration has the potential to yield more variable, less predictable flows at hydro dams, flows that at times could resemble reciprocal wind patterns. An existing body of research explores the impacts of standard, demand-following hydroelectric dams on downstream ecological flows; but weighing the benefits of increased reliance on wind power against further impacts to ecological flows may be a novel challenge for the environmental community. As a preliminary step in meeting this

  7. Pulse laser imaging amplifier for advanced ladar systems

    Science.gov (United States)

    Khizhnyak, Anatoliy; Markov, Vladimir; Tomov, Ivan; Murrell, David

    2016-05-01

    Security measures sometimes require persistent surveillance of government, military and public areas Borders, bridges, sport arenas, airports and others are often surveilled with low-cost cameras. Their low-light performance can be enhanced with laser illuminators; however various operational scenarios may require a low-intensity laser illumination with the object-scattered light intensity lower than the sensitivity of the Ladar image detector. This paper discusses a novel type of high-gain optical image amplifier. The approach enables time-synchronization of the incoming and amplifying signals with accuracy <= 1 ns. The technique allows the incoming signal to be amplified without the need to match the input spectrum to the cavity modes. Instead, the incoming signal is accepted within the spectral band of the amplifier. We have gauged experimentally the performance of the amplifier with a 40 dB gain and an angle of view 20 mrad.

  8. A Review of High Voltage Drive Amplifiers for Capacitive Actuators

    DEFF Research Database (Denmark)

    Huang, Lina; Zhang, Zhe; Andersen, Michael A. E.

    2012-01-01

    This paper gives an overview of the high voltage amplifiers, which are used to drive capacitive actuators. The amplifiers for both piezoelectric and DEAP (dielectric electroactive polymer) actuator are discussed. The suitable topologies for driving capacitive actuators are illustrated in detail, ......, including linear as well as switched mode amplifiers. In the past much attention has been paid on the driver for piezoelectric actuator. As DEAP is a type of new material, there is not much literature reference for it.......This paper gives an overview of the high voltage amplifiers, which are used to drive capacitive actuators. The amplifiers for both piezoelectric and DEAP (dielectric electroactive polymer) actuator are discussed. The suitable topologies for driving capacitive actuators are illustrated in detail...

  9. New design of sense amplifier for EEPROM memory

    Institute of Scientific and Technical Information of China (English)

    Dong-sheng LIU; Xue-cheng ZOU; Qiong YU; Fan ZHANG

    2009-01-01

    We present a new sense amplifier circuit for EEPROM memory. The topology of the sense amplifier uses a voltage sensing method, having low cost and low power consumption as well as high reliability. The sense amplifier was implemented in an EEPROM realized with an SMIC 0.35-μm 2P3M CMOS embedded EEPROM process. Under the condition that the power supply is 3.3 V, simulation results showed that the charge time is 35 ns in the proposed sense amplifier, and that the maximum average current consumption during the read period is 40 μA. The novel topology allows the circuit to function with power sup-plies as low as 1.4 V. The sense amplifier has been implemented in 2-kb EEPROM memory for RFID tag IC applications, and has a silicon area of only 240 μm2.

  10. Highly Stable,Diode-Pumped Nd:YLF Regenerative Amplifier

    Institute of Scientific and Technical Information of China (English)

    WANG Jiang-Feng; LI Xue-Chun; WEI Hui; ZHU Jian-Qiang

    2008-01-01

    We present the design and experimental results for a diode pumped Nd:YLF regenerative amplifier applied to amplify a nanosecond laser pulse.Numerical simulation shows that the maximum output energy and the best stability can be obtained when the regenerative amplifier operates in a saturated mode for all pulse duration and temporal profiles.Using extra post-pulse is a good method to decrease the square-pulse distortion caused by gain saturation effect.The amplifier shows output energy of 4.2mJ with a total energy gain of more than 107 and output energy stability of better than 1% rms.When extra post-pulse is added,square-pulse distortion is decreased from 1.33 to 1.17 for the amplifier that is seeded with an optical pulse of 3 ns.

  11. Coupled Lines Filters for Broadband Impedance Matching of Microwave Amplifiers

    Directory of Open Access Journals (Sweden)

    Mohammed Lahsaini

    2014-08-01

    Full Text Available In this paper we present a broadband matching technique for the design of low noise amplifiers. This technique is based on the use of coupled lines filters and quarter wave transformers for the adaptation and stabilization of these amplifiers, presenting the theory and the design process of these circuits. The type of transistors used for modeling this amplifier is the HEMT of Alpha Industries®. The results we found show that this amplifier is unconditionally stable with a satisfactory gain of about 20 dB and good impedance matching across the band of interest [10-12] GHz. The amplifier modeled in this work can be integrated in satellite receiving systems and radar systems.

  12. Digital Lock-in Amplifier Based on Microcontroller

    Institute of Scientific and Technical Information of China (English)

    An-li TAO; Guo-dong XU; Ke-xue LUO; Gang-ling ZHANG

    2010-01-01

    A method of implementing high cost-effective and highly integrated digital lock-in amplifier with microcontroller is discussed. And the digital lock-in amplifier is more suitable for measuring low-frequency weak signal.Digital signal sequence is obtained through sampling signal measured over an integer number of signal periods, but digital reference sequence is acquired through mathematical operation, then digital phase sensitive detection can be implemented by calculating the cross-correlation function of digital signal sequence and digital reference sequence.In addition, the frequency response and phase character of the digital lock-in amplifier is analyzed. Finally, the designed digital lock-in amplifier is achieved. Experimental results show that the digital lock-in amplifier can be used for measuring weak signal with low ignal-to-noise ratio.

  13. Quantum Dot Semiconductor Optical Amplifiers - Physics and Applications

    DEFF Research Database (Denmark)

    Berg, Tommy Winther

    2004-01-01

    This thesis describes the physics and applications of quantum dot semiconductor optical amplifiers based on numerical simulations. These devices possess a number of unique properties compared with other types of semiconductor amplifiers, which should allow enhanced performance of semiconductor...... respects is comparable to those of fiber amplifiers. The possibility of inverting the optically active states to a large degree is essential in order to achieve this performance. Optical signal processing through cross gain modulation and four wave mixing is modeled and described. For both approaches...... and QW devices and to experiments on quantum dot amplifiers. These comparisons outline the qualitative differences between the different types of amplifiers. In all cases focus is put on the physical processes responsible the differences....

  14. Extraction and downstream processing of plant-derived recombinant proteins.

    Science.gov (United States)

    Buyel, J F; Twyman, R M; Fischer, R

    2015-11-01

    Plants offer the tantalizing prospect of low-cost automated manufacturing processes for biopharmaceutical proteins, but several challenges must be addressed before such goals are realized and the most significant hurdles are found during downstream processing (DSP). In contrast to the standardized microbial and mammalian cell platforms embraced by the biopharmaceutical industry, there are many different plant-based expression systems vying for attention, and those with the greatest potential to provide inexpensive biopharmaceuticals are also the ones with the most significant drawbacks in terms of DSP. This is because the most scalable plant systems are based on the expression of intracellular proteins in whole plants. The plant tissue must therefore be disrupted to extract the product, challenging the initial DSP steps with an unusually high load of both particulate and soluble contaminants. DSP platform technologies can accelerate and simplify process development, including centrifugation, filtration, flocculation, and integrated methods that combine solid-liquid separation, purification and concentration, such as aqueous two-phase separation systems. Protein tags can also facilitate these DSP steps, but they are difficult to transfer to a commercial environment and more generic, flexible and scalable strategies to separate target and host cell proteins are preferable, such as membrane technologies and heat/pH precipitation. In this context, clarified plant extracts behave similarly to the feed stream from microbes or mammalian cells and the corresponding purification methods can be applied, as long as they are adapted for plant-specific soluble contaminants such as the superabundant protein RuBisCO. Plant-derived pharmaceutical proteins cannot yet compete directly with established platforms but they are beginning to penetrate niche markets that allow the beneficial properties of plants to be exploited, such as the ability to produce 'biobetters' with tailored

  15. Upstream plasticity and downstream robustness in evolution of molecular networks

    Directory of Open Access Journals (Sweden)

    Eriksen Kasper

    2004-03-01

    Full Text Available Abstract Background Gene duplication followed by the functional divergence of the resulting pair of paralogous proteins is a major force shaping molecular networks in living organisms. Recent species-wide data for protein-protein interactions and transcriptional regulations allow us to assess the effect of gene duplication on robustness and plasticity of these molecular networks. Results We demonstrate that the transcriptional regulation of duplicated genes in baker's yeast Saccharomyces cerevisiae diverges fast so that on average they lose 3% of common transcription factors for every 1% divergence of their amino acid sequences. The set of protein-protein interaction partners of their protein products changes at a slower rate exhibiting a broad plateau for amino acid sequence similarity above 70%. The stability of functional roles of duplicated genes at such relatively low sequence similarity is further corroborated by their ability to substitute for each other in single gene knockout experiments in yeast and RNAi experiments in a nematode worm Caenorhabditis elegans. We also quantified the divergence rate of physical interaction neighborhoods of paralogous proteins in a bacterium Helicobacter pylori and a fly Drosophila melanogaster. However, in the absence of system-wide data on transcription factors' binding in these organisms we could not compare this rate to that of transcriptional regulation of duplicated genes. Conclusions For all molecular networks studied in this work we found that even the most distantly related paralogous proteins with amino acid sequence identities around 20% on average have more similar positions within a network than a randomly selected pair of proteins. For yeast we also found that the upstream regulation of genes evolves more rapidly than downstream functions of their protein products. This is in accordance with a view which puts regulatory changes as one of the main driving forces of the evolution. In this

  16. A microelectrochemical scanning flow cell with downstream analytics

    International Nuclear Information System (INIS)

    Research highlights: → A flow type scanning droplet cell with in situ detection via UV-vis to investigate corrosion was constructed. → Dependency of OCP of Zn on pH between 6.6 and 9.0 was studied with passive active transition between pH 7.1 and 7.4. → Zinc concentration profiles revealed a steady etching process that is diffusion controlled at all pH values → Sulfate ions interfere with the passivity of zinc and increase the etching rate, they also influence the pitting potential. - Abstract: The combination of a capillary based microelectrochemical flow cell system and downstream UV-vis analytics allows obtaining synchronized electrochemical and spectroscopic data in a fully automated mode. This method combination can be generally applied to microelectrochemical studies in which an electrochemical species is released or consumed during the electrochemical reaction. For the example of pure zinc surfaces, the characterization of the integrated spectroscopic system is presented with a Zn2+ detection limit below 0.1 μmol l-1 using Zincon as complexing agent. A parameter screening of the effect of pH in the range of 6.6-9.0 in borate buffer reveals a linear increase in zinc dissolution with proton concentration but a distinct step in the open circuit potential from the active state (around -700 mV SHE, pH 6.6-7.1) to the passive state (around -300 mV SHE, pH 7.4-9.0) indicating the formation of a closed passive layer. This mechanism is strongly influenced by sulfate anions which increase the dissolution rate of the passive film and promote the active state as monitored by the dissolution profile and OCP (open circuit potential) values. Within the scope of this parameter variation, the congruency between OCP transients, potentiodynamic sweeps and time resolved dissolution profiles is discussed.

  17. Single Ion Quantum Lock-In Amplifier

    CERN Document Server

    Kotler, Shlomi; Glickman, Yinnon; Keselman, Anna; Ozeri, Roee

    2011-01-01

    We report on the implementation of a quantum analog to the classical lock-in amplifier. All the lock-in operations: modulation, detection and mixing, are performed via the application of non-commuting quantum operators on the electronic spin state of a single trapped Sr+ ion. We significantly increase its sensitivity to external fields while extending phase coherence by three orders of magnitude, to more than one second. With this technique we measure magnetic fields with sensitivity of 25 pT/sqrt(Hz) and light shifts with an uncertainty below 140 mHz after 1320 seconds of averaging. These sensitivities are limited by quantum projection noise and, to our knowledge, are more than two orders of magnitude better than with other single-spin probe technologies. In fact, our reported sensitivity is sufficient for the measurement of parity non-conservation, as well as the detection of the magnetic field of a single electronic-spin one micrometer from an ion-detector with nanometer resolution. As a first application ...

  18. Efficient and Compact Optical Amplifier Using EYDF

    Directory of Open Access Journals (Sweden)

    Sulaiman Wadi Harun

    2010-09-01

    Full Text Available An efficient Erbium/Ytterbium doped fiber amplifier (EYDFA is demonstrated using a 1058nm pumping wavelength, where the amplification is assisted by energy transfer between Yb and Er ions. The energy transfer increases the limit of erbium doping concentration that is imposed by concentration quenching in Erbium-doped fiber (EDF. Therefore, the gain and noise figure are severely degraded with 1480 nm pumping, where the energy transfer cannot be achieved. The use of optical isolator improves the small signal gain and noise figure by about 4.8 dB and 1.6 dB, respectively. By employing a double-pass configuration, a higher gain can be obtained with an expense of a noise figure penalty. The gain improvement of 17.0 dB is obtained at 20 mW and -50 dBm of pump and input signal powers. This shows that the double-pass configuration is an important aspect to consider when designing an efficient EYDFA.

  19. Status Report on the Energy Amplifier

    CERN Document Server

    Rubbia, Carlo

    1994-01-01

    0ne year after its first presentation,the Energy Amplifier (EA) Project holds its promises for a environmentally acceptable form of energy extraction from nuclei, namely to eliminate or at least greatly reduce(i) the environmental impact of the long-lived highly radioactive waste;(ii) the possibility of diversions toward military applications;(iii) the risks of an accidental divergence related to the critical operation of the chain reaction and (iv) make a more efficient use of a fuel which is less radio-toxic to extract and more abundant on Earth than Uranium. In these respects the EA (or equivalent scenarios from Los Alamos and elsewhere) is comparable in performance to Thermonuclear Fusion. Bot h approches offer pratically unl;imited fuel resources: the energetic content of Lithium on the Earth's crust needed by Fusion is estimated to be seven times the one of Thorium and they are both adequate for millions of years of very intensived utilisation.However the EA can be built economically,in a variety of siz...

  20. Gold Nanoparticle Labels Amplify Ellipsometric Signals

    Science.gov (United States)

    Venkatasubbarao, Srivatsa

    2008-01-01

    The ellipsometric method reported in the immediately preceding article was developed in conjunction with a method of using gold nanoparticles as labels on biomolecules that one seeks to detect. The purpose of the labeling is to exploit the optical properties of the gold nanoparticles in order to amplify the measurable ellipsometric effects and thereby to enable ultrasensitive detection of the labeled biomolecules without need to develop more-complex ellipsometric instrumentation. The colorimetric, polarization, light-scattering, and other optical properties of nanoparticles depend on their sizes and shapes. In the present method, these size-and-shape-dependent properties are used to magnify the polarization of scattered light and the diattenuation and retardance of signals derived from ellipsometry. The size-and-shape-dependent optical properties of the nanoparticles make it possible to interrogate the nanoparticles by use of light of various wavelengths, as appropriate, to optimally detect particles of a specific type at high sensitivity. Hence, by incorporating gold nanoparticles bound to biomolecules as primary or secondary labels, the performance of ellipsometry as a means of detecting the biomolecules can be improved. The use of gold nanoparticles as labels in ellipsometry has been found to afford sensitivity that equals or exceeds the sensitivity achieved by use of fluorescence-based methods. Potential applications for ellipsometric detection of gold nanoparticle-labeled biomolecules include monitoring molecules of interest in biological samples, in-vitro diagnostics, process monitoring, general environmental monitoring, and detection of biohazards.

  1. Fishing amplifies forage fish population collapses

    Science.gov (United States)

    Essington, Timothy E.; Moriarty, Pamela E.; Froehlich, Halley E.; Hodgson, Emma E.; Koehn, Laura E.; Oken, Kiva L.; Siple, Margaret C.; Stawitz, Christine C.

    2015-01-01

    Forage fish support the largest fisheries in the world but also play key roles in marine food webs by transferring energy from plankton to upper trophic-level predators, such as large fish, seabirds, and marine mammals. Fishing can, thereby, have far reaching consequences on marine food webs unless safeguards are in place to avoid depleting forage fish to dangerously low levels, where dependent predators are most vulnerable. However, disentangling the contributions of fishing vs. natural processes on population dynamics has been difficult because of the sensitivity of these stocks to environmental conditions. Here, we overcome this difficulty by collating population time series for forage fish populations that account for nearly two-thirds of global catch of forage fish to identify the fingerprint of fisheries on their population dynamics. Forage fish population collapses shared a set of common and unique characteristics: high fishing pressure for several years before collapse, a sharp drop in natural population productivity, and a lagged response to reduce fishing pressure. Lagged response to natural productivity declines can sharply amplify the magnitude of naturally occurring population fluctuations. Finally, we show that the magnitude and frequency of collapses are greater than expected from natural productivity characteristics and therefore, likely attributed to fishing. The durations of collapses, however, were not different from those expected based on natural productivity shifts. A risk-based management scheme that reduces fishing when populations become scarce would protect forage fish and their predators from collapse with little effect on long-term average catches. PMID:25848018

  2. Undercover Stars Among Exoplanet Candidates

    Science.gov (United States)

    2005-03-01

    events by monitoring the brightness of a very large number of stars over extended time intervals. During the past years, it has also included a search for periodic, very shallow "dips" in the brightness of stars, caused by the regular transit of small orbiting objects (small stars, brown dwarfs [2] or Jupiter-size planets). The OGLE team has since announced 177 "planetary transit candidates" from their survey of several hundred thousand stars in three southern sky fields, one in the direction of the Galactic Centre, another within the Carina constellation and the third within the Centaurus/Musca constellations. The nature of the transiting object can however only be established by subsequent radial-velocity observations of the parent star. The size of the velocity variations (the amplitude) is directly related to the mass of the companion object and therefore allows discrimination between stars and planets as the cause of the observed brightness "dip". A Bonanza of Low-Mass Stars An international team of astronomers [3] has made use of the 8.2-m VLT Kueyen telescope for this work. Profiting from the multiplex capacity of the FLAMES/UVES facility that permits to obtain high-resolution spectra of up to 8 objects simultaneously, they have looked at 60 OGLE transit candidate stars, measuring their radial velocities with an accuracy of about 50 m/s [4]. This ambitious programme has so far resulted in the discovery of five new transiting exoplanets (see, e.g., ESO PR 11/04 for the announcement of two of those). Most of the other transit candidates identified by OGLE have turned out to be eclipsing binaries, that is, in most cases common, small and low-mass stars passing in front of a solar-like star. This additional wealth of data on small and light stars is a real bonanza for the astronomers. Constraining the Relation Between Mass and Radius Low-mass stars are exceptionally interesting objects, also because the physical conditions in their interiors have much in common with

  3. Estimation of Flood Warning Times for Flood Safety Management Downstream of Dams

    OpenAIRE

    Saqib Ehsan; Walter Marx; Silke Wieprecht

    2013-01-01

    Floods have always been a threat for people and property due to the extent of possible damages. The flooding could be catastrophic in case of possible dam failure and its impacts on downstream areas could also be very significant. Proper estimation of flood warning times plays a vital role in flood safety management of areas downstream of the dams. This research focuses on the realistic and precise estimation of flood warning times for the downstream areas in case of possible dam failure. As ...

  4. Implementation of envelope tracking for RF solid state amplifiers

    Science.gov (United States)

    Larter, Thomas Leigh

    The Facility for Rare Isotope Beams (FRIB) is currently in its development stages at Michigan State University. The facility uses a large linear accelerator system to accelerate ionized particles which are then collided with other particles in the hopes of finding rare isotopes of elements. This accelerating action depends on several systems to function, with one of the major systems being superconducting cavity structures. These cavities are driven by high-power RF amplifiers which account for a large portion of the accelerator's power consumption. It is important to maximize the efficiency of these amplifiers in order to keep energy costs for the facility low. One of the ways to increase efficiency is to choose an amplifier topology that is highly efficient. A study was done for FRIB testing the prospect of using amplifiers with the envelope tracking (ET) topology. An amplifier's efficiency relies on its output power and the power supplied to it, which are in turn directly related to the output signal voltage and supply rail voltage. In an ET RF amplifier, the supply voltage is made to closely follow the envelope of the output signal voltage. This tracking action allows the RF amplifier to operate with much improved efficiency at low power levels and nearly constant efficiency at high power levels. The ET tests performed for FRIB attempted to verify the validity of ET efficiency gains for RF amplifiers. These tests included the characterization of an RF amplifier, development and verification of an ET control algorithm, and implementation of an ET test bench using FRIB equipment. These tests should attest to the purported increase in efficiency possible with ET and prove that the power consumption budget for the FRIB will benefit from the use of such amplifiers.

  5. Study on the E-beam pulse width scaling for a 25-kilojoule KrF amplifier

    International Nuclear Information System (INIS)

    The KrF laser is being considered as an ICF driver candidate. Since this laser is not an energy storing system, the output energy of an amplifier is delivered over the entire pulse width of the excitation source. E-beam pumping is preferred for large energy systems. The e-beam pulse width is constrained to a few hundred nanoseconds by laser operation and pulsed power considerations. The target requires pulses of a few nanoseconds. Angular multiplexing of probe beams through the amplifier is a preferred scheme for bridging this difference in timing requirements. Progressively shorter target irradiation times may be obtained by using shorter pulse probe beams and by either increasing the number of angular multiplexed beams or by decreasing the e-beam pulse width. This report documents results of a study on the consequences of following the latter approach

  6. Doublesex: a conserved downstream gene controlled by diverse upstream regulators

    Indian Academy of Sciences (India)

    J. N. Shukla; J. Nagaraju

    2010-09-01

    Sex determination, an integral precursor to sexual reproduction, is required to generate morphologically distinct sexes. The molecular components of sex-determination pathways regulating sexual differentiation have been identified and characterized in different organisms. The Drosophila doublesex (dsx) gene at the bottom of the sex-determination cascade is the best characterized candidate so far, and is conserved from worms (mab3 of Caenorhabditis elegans) to mammals (Dmrt-1). Studies of dsx homologues from insect species belonging to different orders position them at the bottom of their sex-determination cascade. The dsx homologues are regulated by a series of upstream regulators that show amazing diversity in different insect species. These results support the Wilkin’s hypothesis that evolution of the sex-determination cascade has taken place in reverse order, the bottom most gene being most conserved and the upstream genes having been recruited at different times during evolution. The pre-mRNA of dsx is sex-specifically spliced to encode male or female-specific transcription factors that play an important role in the regulation of sexually dimorphic characters in different insect species. The generalization that dsx is required for somatic sexual differentiation culminated with its functional analysis through transgenesis and knockdown experiments in diverse species of insects. This brief review will focus on the similarities and variations of dsx homologues that have been investigated in insects to date.

  7. Special Education Teacher Candidate Assessment: A Review

    Science.gov (United States)

    McCall, Zach; McHatton, Patricia Alvarez; Shealey, Monika Williams

    2014-01-01

    Teacher preparation has been under intense scrutiny in recent years. In order for preparation of special education teacher candidates to remain viable, candidate assessment practices must apply practices identified in the extant literature base, while special education teacher education researchers must extend this base with rigorous efforts to…

  8. 11 CFR 110.13 - Candidate debates.

    Science.gov (United States)

    2010-01-01

    ... political parties may stage candidate debates in accordance with this section and 11 CFR 114.4(f). (2... also cover or carry candidate debates in accordance with 11 CFR part 100, subparts B and C and part 100... CFR 114.4(f), provided that they are not owned or controlled by a political party, political...

  9. Direct solar-pumped iodine laser amplifier

    Science.gov (United States)

    Han, Kwang S.; Hwang, In Heon; Kim, Khong Hon; Stock, Larry V.

    1988-01-01

    A XeCl laser pumped iodine laser oscillator was developed which will be incorporated into the Master Oscillator Power Amplifier (MOPA) system. The developed XeCl laser produces output energy of about 60 mJ per pulse. The pulse duration was about 10 nsec. The kinetic model for the solar-pumped laser was refined and the algorithm for the calculation of a set of rate equations was improved to increase the accuracy and the efficiency of the calculation. The improved algorithm was applied to explain the existing experimental data taken from a flashlamp pumped iodine laser for three kinds of lasants, i-C3F7I, n-C4F9I, and t-C4F9I. Various solid laser materials were evaluated for solar-pumping. The materials studied were Nd:YAG, Nd:YLF, and Cr:Nd:GSGG crystals. The slope efficiency of 0.17 percent was measured for the Nd:YLF near the threshold pump intensity which was 211 solar constants (29W/sq cm). The threshold pump intensity of the Nd:YAG was measured to be 236 solar constants (32W/sq cm) and the near-threshold slope efficiency was 0.12 percent. True CW laser operation of Cr:Nd:GSGG was possible only at pump intensities less than or equal to 1,500 solar constants (203 W/sq cm). This fact was attributed to the high thermal focusing effect of the Cr:Nd:GSGG rod.

  10. Transfer of sediment-associated metals downstream of abandoned and active mining sites in the Quesnel River catchment, British Columbia

    NARCIS (Netherlands)

    Perk, M. van der; Lipzig, M.L.H.M. van; Karimlou, G.; Owens, P.N.; Petticrew, E.L.

    2011-01-01

    Metal mining may have considerable impact on downstream water and sediment composition. The rate and extent that metals move downstream determine the magnitude and time scale of downstream sediment contamination. Conversely, the downstream metal content of sediments provide important clues of sedime

  11. Ambient temperature cadmium zinc telluride radiation detector and amplifier circuit

    International Nuclear Information System (INIS)

    A low noise, low power consumption, compact, ambient temperature signal amplifier for a Cadmium Zinc Telluride (CZT) radiation detector is disclosed. The amplifier can be used within a larger system (e.g., including a multi-channel analyzer) to allow isotopic analysis of radionuclides in the field. In one embodiment, the circuit stages of the low power, low noise amplifier are constructed using integrated circuit (IC) amplifiers , rather than discrete components, and include a very low noise, high gain, high bandwidth dual part preamplification stage, an amplification stage, and an filter stage. The low noise, low power consumption, compact, ambient temperature amplifier enables the CZT detector to achieve both the efficiency required to determine the presence of radionuclides and the resolution necessary to perform isotopic analysis to perform nuclear material identification. The present low noise, low power, compact, ambient temperature amplifier enables a CZT detector to achieve resolution of less than 3% full width at half maximum at 122 keV for a Cobalt-57 isotope source. By using IC circuits and using only a single 12 volt supply and ground, the novel amplifier provides significant power savings and is well suited for prolonged portable in-field use and does not require heavy, bulky power supply components. 9 figs

  12. A modular positive feedback-based gene amplifier

    Directory of Open Access Journals (Sweden)

    Bhalerao Kaustubh D

    2010-02-01

    Full Text Available Abstract Background Positive feedback is a common mechanism used in the regulation of many gene circuits as it can amplify the response to inducers and also generate binary outputs and hysteresis. In the context of electrical circuit design, positive feedback is often considered in the design of amplifiers. Similar approaches, therefore, may be used for the design of amplifiers in synthetic gene circuits with applications, for example, in cell-based sensors. Results We developed a modular positive feedback circuit that can function as a genetic signal amplifier, heightening the sensitivity to inducer signals as well as increasing maximum expression levels without the need for an external cofactor. The design utilizes a constitutively active, autoinducer-independent variant of the quorum-sensing regulator LuxR. We experimentally tested the ability of the positive feedback module to separately amplify the output of a one-component tetracycline sensor and a two-component aspartate sensor. In each case, the positive feedback module amplified the response to the respective inducers, both with regards to the dynamic range and sensitivity. Conclusions The advantage of our design is that the actual feedback mechanism depends only on a single gene and does not require any other modulation. Furthermore, this circuit can amplify any transcriptional signal, not just one encoded within the circuit or tuned by an external inducer. As our design is modular, it can potentially be used as a component in the design of more complex synthetic gene circuits.

  13. Development of a Single-Pass Amplifier for an Optical Stochastic Cooling Proof-of-Principle Experiment at Fermilab's IOTA Facility

    Energy Technology Data Exchange (ETDEWEB)

    Andorf, M. B. [NICADD, DeKalb; Lebedev, V. A. [Fermilab; Piot, P. [NIU, DeKalb

    2015-06-01

    Optical stochastic cooling (OSC) is a method of beam cooling which is expected to provide cooling rates orders of magnitude larger than ordinary stochastic cooling. Light from an undulator (the pickup) is amplified and fed back onto the particle beam via another undulator (the kicker). Fermilab is currently exploring a possible proof-of-principle experiment of the OSC at the integrable-optics test accelerator (IOTA) ring. To implement effective OSC a good correction of phase distortions in the entire band of the optical amplifier is required. In this contribution we present progress in experimental characterization of phase distortions associated to a Titanium Sapphire crystal laser-gain medium (a possible candidate gain medium for the OSC experiment to be performed at IOTA). We also discuss a possible option for a mid-IR amplifier

  14. Optimization and Performance Analysis of Bulk-Driven Differential Amplifier

    Directory of Open Access Journals (Sweden)

    Antarpreet kaur

    2014-04-01

    Full Text Available In recent years, there has been an increasing demand for high-speed digital circuits at low power consumption. This paper presents a design of input stage of Operational Amplifier i.e cascode differential amplifier using a standard 65nm CMOS Technology.A comparison betweem gate-driven, bulk-driven and cascode bulk driven bulk-driven differential amplifier is described. The Results demonstrate that CMMR is 83.98 dB, 3-dB Bandwidth is 1.04 MHz. The circuit dissipate power of 28uWunder single supply of 1.0V.

  15. Amplifier circuit operable over a wide temperature range

    Science.gov (United States)

    Kelly, Ronald D.; Cannon, William L.

    1979-01-01

    An amplifier circuit having stable performance characteristics over a wide temperature range from approximately 0.degree. C up to as high as approximately 500.degree. C, such as might be encountered in a geothermal borehole. The amplifier utilizes ceramic vacuum tubes connected in directly coupled differential amplifier pairs having a common power supply and a cathode follower output stage. In an alternate embodiment, for operation up to 500.degree. C, positive and negative power supplies are utilized to provide improved gain characteristics, and all electrical connections are made by welding. Resistor elements in this version of the invention are specially heat treated to improve their stability with temperature.

  16. Class-D audio amplifiers with negative feedback

    OpenAIRE

    Cox, Stephen M.; Candy, B. H.

    2006-01-01

    There are many different designs for audio amplifiers. Class-D, or switching, amplifiers generate their output signal in the form of a high-frequency square wave of variable duty cycle (ratio of on time to off time). The square-wave nature of the output allows a particularly efficient output stage, with minimal losses. The output is ultimately filtered to remove components of the spectrum above the audio range. Mathematical models are derived here for a variety of related class-D amplifier d...

  17. FDML swept source at 1060 nm using a tapered amplifier

    DEFF Research Database (Denmark)

    Marschall, Sebastian; Klein, Thomas; Wieser, Wolfgang;

    2010-01-01

    We present a novel frequency-swept light source working at 1060nm that utilizes a tapered amplifier as gain medium. These devices feature significantly higher saturation power than conventional semiconductor optical amplifiers and can thus improve the limited output power of swept sources...... in this wavelength range. We demonstrate that a tapered amplifier can be integrated into a fiber-based swept source and allows for high-speed FDML operation. The developed light source operates at a sweep rate of 116kHz with an effective average output power in excess of 30mW. With a total sweep range of 70 nm...

  18. Design procedure for optimizing CMOS low noise operational amplifiers

    Institute of Scientific and Technical Information of China (English)

    Li Zhiyuan; Ye Yizheng; Ma Jianguo

    2009-01-01

    This paper presents and experimentally verifies an optimized design procedure for a CMOS low noise operational amplifier.The design procedure focuses on the noise performance,which is the key requirement for low noise operational amplifiers.Based on the noise level and other specifications such as bandwidth,signal swing,slew rate,and power consumption,the device sizes and the biasing conditions are derived.In order to verify the proposed design procedure,a three-stage operational amplifier has been designed.The device parameters obtained from the proposed design procedure closely agree with the simulated results obtained by using HSPICE.

  19. MMIC DHBT Common-Base Amplifier for 172 GHz

    Science.gov (United States)

    Paidi, Vamsi; Griffith, Zack; Wei, Yun; Dahlstrom, Mttias; Urteaga, Miguel; Rodwell, Mark; Samoska, Lorene; Fung, King Man; Schlecht, Erich

    2006-01-01

    Figure 1 shows a single-stage monolithic microwave integrated circuit (MMIC) power amplifier in which the gain element is a double-heterojunction bipolar transistor (DHBT) connected in common-base configuration. This amplifier, which has been demonstrated to function well at a frequency of 172 GHz, is part of a continuing effort to develop compact, efficient amplifiers for scientific instrumentation, wide-band communication systems, and radar systems that will operate at frequencies up to and beyond 180 GHz. The transistor is fabricated from a layered structure formed by molecular beam epitaxy in the InP/InGaAs material system. A highly doped InGaAs base layer and a collector layer are fabricated from the layered structure in a triple mesa process. The transistor includes two separate emitter fingers, each having dimensions of 0.8 by 12 m. The common-base configuration was chosen for its high maximum stable gain in the frequency band of interest. The input-matching network is designed for high bandwidth. The output of the transistor is matched to a load line for maximum saturated output power under large-signal conditions, rather than being matched for maximum gain under small-signal conditions. In a test at a frequency of 172 GHz, the amplifier was found to generate an output power of 7.5 mW, with approximately 5 dB of large-signal gain (see Figure 2). Moreover, the amplifier exhibited a peak small-signal gain of 7 dB at a frequency of 176 GHz. This performance of this MMIC single-stage amplifier containing only a single transistor represents a significant advance in the state of the art, in that it rivals the 170-GHz performance of a prior MMIC three-stage, four-transistor amplifier. [The prior amplifier was reported in "MMIC HEMT Power Amplifier for 140 to 170 GHz" (NPO-30127), NASA Tech Briefs, Vol. 27, No. 11 (November 2003), page 49.] This amplifier is the first heterojunction- bipolar-transistor (HBT) amplifier built for medium power operation in this

  20. 120 nm Bandwidth Erbium-doped Fiber Amplifier

    Institute of Scientific and Technical Information of China (English)

    姜淳; 曾庆济; 肖石林

    2002-01-01

    A new dual band erbium-doped fiber amplifier configuration that provides 120 nm of optical bandwidth is simulated. This configuration employs a split-band architecture in which optical signals are splitted using a 1550/1610 nm port filter into two independent sub-bands which then pass in parallel through separate branches of the optical amplifier. Each branch may be optimized for the sub-band that traverses it. The independent sub-bands are combined and flattened before output, resulting in a 120 nm bandwidth gain-flattened optical amplifier.

  1. Influence of mode competition on beam quality of fiber amplifier

    International Nuclear Information System (INIS)

    Theoretical and experimental studies of the influence of the mode competition on the output beam quality of fiber amplifiers are presented. Rate equations and modal decomposition method are used in the theoretical model. In the experiment, the output beam-quality factor of a fiber amplifier, which is based on a Yb-doped double-clad large mode area fiber as a function of the seed beam quality and the pump power of the amplifier, is measured. The experimental results are consistent with the theoretical analysis. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  2. Novel asymmetrical twin-core photonic crystal fiber for gain-flattened Raman amplifier

    Institute of Scientific and Technical Information of China (English)

    JIANG HaiMing; XIE Kang; WANG YaFei

    2009-01-01

    A novel asymmetrical twin-core photonic crystal fiber was proposed,whose effective overlap core areaAeff can be designed to synchronize the variation of Raman gain coefficient with respect to frequency.This fiber possesses a higher and flatter Raman gain efficiency coefficient curve rR=gR/Aeff over a specified band of wavelength than a conventional fiber.Therefore,it is a good candidate of gain medium for a flat,broad gain band fiber Raman amplifier.It was numerically demonstrated that for the Raman gain efficiency rR,relative fluctuations of less than 2.2% and 5.7% are achievable in the C (1530-1565 nm)band and L(1565-1625 nm)band,respectively.

  3. Novel asymmetrical twin-core photonic crystal fiber for gain-flattened Raman amplifier

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    A novel asymmetrical twin-core photonic crystal fiber was proposed, whose effective overlap core area Aeff can be designed to synchronize the variation of Raman gain coefficient with respect to frequency. This fiber possesses a higher and flatter Raman gain efficiency coefficient curve rR=gR/Aeff over a specified band of wavelength than a conventional fiber. Therefore, it is a good candidate of gain me- dium for a flat, broad gain band fiber Raman amplifier. It was numerically demonstrated that for the Raman gain efficiency rR, relative fluctuations of less than 2.2% and 5.7% are achievable in the C (1530―1565 nm) band and L (1565―1625 nm) band, respectively.

  4. Phospho-tellurite glasses containing heavy metal oxides for ultrabroad band fiber Raman amplifiers

    International Nuclear Information System (INIS)

    Multicomponent phospho-tellurite glasses containing heavy metal oxides and alkaline earth oxides have been fabricated. These glasses have thermal stabilities as high as 224 deg. C, which make them suitable for various fiber devices applications. The Raman intensities and cross sections of these glasses are compared relative to silica. These glasses show superior relative Raman cross sections than silica and conventional tellurite glasses. The presence of heavy metal oxides and alkaline earth oxides makes the Raman bands due to TeO2 and P2O5 continuous and one such glass has continuous Raman bandwidths exceeding 700 cm-1. Thus, these glasses could be potential candidates for ultrawide band fiber Raman amplifiers

  5. Experimental and theoretical investigation of semiconductor optical amplifier (SOA) based all-optical switches

    DEFF Research Database (Denmark)

    Nielsen, Mads Lønstrup

    2004-01-01

    , consisting of an SOA and an asymmetric MZI filter, is analyzed in the small-signal regime, and the obtainable modulation bandwidth is expressed analytically. A new optical spectrum approach to small signal analysis is introduced, and is used to assess the bandwidth enhancing effect of different optical......This thesis analyzes semiconductor optical amplifier (SOA) based all-optical switches experimentally and through numerical simulations. These devices are candidates for optical signal processing functionalities such as wavelength conversion, regeneration, and logic processing in future transparent...... optical networks. The factors governing the modulation bandwidth of SOAs are determined, and schemes for reducing detrimental patterning effects are discussed. Three types of SOA-based switches are investigated numerically: so-called standardmode and differential-mode switches, and the filtering assisted...

  6. A 40-Gbit/s 1-to-2 Photonic Data Distributor Employing a Single Semiconductor Optical Amplifier

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yin; DONG Jian-Ji; LEI Lei; HE Hao; HUANG De-Xiu; ZHANG Xin-Liang

    2011-01-01

    @@ A simple design of 1-to-2 photonic data distributor is proposed.A proof-of-concept experiment is performed at 40 Gbit/s employing four-wave mixing and cross gain modulation in a single semiconductor optical amplifier.Correct output logic signals with high extinction ratios (over 11 dB) and clear open eyes are obtained, without using any additional input light beam.The scheme would be a promising candidate for future ultrafast all-optical signal processing applications.

  7. 17 CFR 270.57b-1 - Exemption for downstream affiliates of business development companies.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Exemption for downstream affiliates of business development companies. 270.57b-1 Section 270.57b-1 Commodity and Securities Exchanges....57b-1 Exemption for downstream affiliates of business development companies....

  8. DOWNSTREAM-WATER-LEVEL CONTROL TEST RESULTS ON THE WM LATERAL CANAL

    Science.gov (United States)

    On steep canals, distant downstream water-level control can be challenging. SacMan (Software for Automated Canal Management) was developed, in part, to test various distant downstream water level controllers. It was implemented on the WM canal of the Maricopa Stanfield Irrigation and Drainage Distri...

  9. Tunable microstrip SQUID amplifiers for the Gen 2 Axion Dark Matter eXperiment (ADMX)

    Science.gov (United States)

    O'Kelley, Sean; Hilton, Gene; Clarke, John; ADMX Collaboration

    2016-03-01

    We present a series of tunable microstrip SQUID (Superconducting Quantum Interference Device) amplifiers (MSAs) for installation in ADMX. The axion dark matter candidate is detected via Primakoff conversion to a microwave photon in a high-Q (~100,000) tunable microwave cavity cooled with a dilution refrigerator in a 7-tesla magnetic field. The microwave photon frequency ν is a function of the unknown axion mass, so both the cavity and amplifier must be scanned over a wide frequency range. An MSA is a linear, phase-preserving amplifier consisting of a square washer loop, fabricated from a thin Nb film, incorporating two Josephson tunnel junctions with resistive shunts to prevent hysteresis. The input is coupled via a microstrip made from a square Nb coil deposited over the washer with an intervening insulating layer. Tunability is achieved by terminating the microstrip with GaAs varactors that operate below 100 mK. By varying the varactor capacitance with a bias voltage, the resonant frequency is varied by up to a factor of 2. We demonstrate several devices operating below 100 mK, matched to the discrete operating bands of ADMX at frequencies ranging from 560 MHz to 1 GHz. The MSAs exhibit gains exceeding 20 dB and the associated noise temperatures, measured with a hot/cold load, approach the standard quantum limit (hν/kB) . Supported by DOE Grants DE - FG02 - 97ER41029, DE - FG02 - 96ER40956, DE - AC52 - 07NA27344, DE - AC03 - 76SF00098, and the Livermore LDRD program.

  10. Profile of candidate microsatellite markers in Sebastiscus marmoratus using 454 pyrosequencing

    Science.gov (United States)

    Song, Na; Chen, Muyan; Gao, Tianxiang; Yanagimoto, Takashi

    2016-04-01

    Sebastiscus marmoratus is an important sedentary ovoviparous fish distributed in near-shore coastal waters from the coast of China to Japan. Candidate S. marmoratus microsatellite markers were developed in the present study using 454 pyrosequencing, and the marker profile was analyzed. A total of 2 000 000 raw sequence reads were assembled to reduce redundancy. Among them, 1 043 dinucleotide, 925 trinucleotide, 692 tetranucleotide, and 315 pentanucleotide repeats were detected. AC repeats were the most frequent motifs among the dinucleotide repeats, and AAT was the most abundant among the trinucleotide repeats. AAAT, ATAG, and ATCC were the three most common tetranucleotide motifs, and AAGAT and AATAT were the most dominant pentanucleotide motifs. The greatest numbers of loci and potentially amplifiable loci were found in dinucleotide repeats, whereas trinucleotide repeats had the fewest. In summary, a wide range of candidate microsatellite markers were identified in the present study using a rapid and efficient 454 pyrosequencing approach.

  11. Improved tunable microstrip SQUID amplifier for the Axion Dark Matter eXperiment (ADMX)

    Science.gov (United States)

    O'Kelley, Sean; Hansen, Jorn; Mol, Jan-Michael; Hilton, Gene; Clarke, John

    2015-03-01

    We present a series of tunable microstrip SQUID amplifiers (MSAs) for use in ADMX. The axion dark matter candidate is detected via Primakoff conversion to a microwave photon in a high-Q (~ 105) tunable microwave cavity, cooled to 1.6 K or lower, in the presence of a 7-tesla magnetic field. The microwave photon frequency is a function of the unknown axion mass, so that the cavity and amplifier must be scanned over a broad frequency range. An MSA is constructed by flux-coupling a resonant microstrip to a resistively-shunted SQUID biased into the voltage state. We demonstrate gains exceeding 20 dB, at frequencies above 900 MHz. Tunability is achieved by terminating the microstrip with a low inductance GaAs varactor diode that operates at cryogenic temperatures. By varying the voltage bias of the varactor we vary its capacitance, allowing a reflected phase varying from nearly 0 to π at the end of the microstrip, and thus a standing wave tunable from nearly λ/2 to λ/4. With proper design of the microwave environment, a noise temperature of 1/2 to 1/4 of the physical temperature is demonstrated.

  12. A low-power CMOS trans-impedance amplifier for FM/cw ladar imaging system

    Science.gov (United States)

    Hu, Kai; Zhao, Yi-qiang; Sheng, Yun; Zhao, Hong-liang; Yu, Hai-xia

    2013-09-01

    A scannerless ladar imaging system based on a unique frequency modulation/continuous wave (FM/cw) technique is able to entirely capture the target environment, using a focal plane array to construct a 3D picture of the target. This paper presents a low power trans-impedance amplifier (TIA) designed and implemented by 0.18 μm CMOS technology, which is used in the FM/cw imaging ladar with a 64×64 metal-semiconductor-metal(MSM) self-mixing detector array. The input stage of the operational amplifier (op amp) in TIA is realized with folded cascade structure to achieve large open loop gain and low offset. The simulation and test results of TIA with MSM detectors indicate that the single-end trans-impedance gain is beyond 100 kΩ, and the -3 dB bandwidth of Op Amp is beyond 60 MHz. The input common mode voltage ranges from 0.2 V to 1.5 V, and the power dissipation is reduced to 1.8 mW with a supply voltage of 3.3 V. The performance test results show that the TIA is a candidate for preamplifier of the read-out integrated circuit (ROIC) in the FM/cw scannerless ladar imaging system.

  13. Candidate gene analysis and exome sequencing confirm LBX1 as a susceptibility gene for idiopathic scoliosis

    DEFF Research Database (Denmark)

    Grauers, Anna; Wang, Jingwen; Einarsdottir, Elisabet;

    2015-01-01

    that are significantly associated with idiopathic scoliosis in Asian and Caucasian populations, rs11190870 close to the LBX1 gene being the most replicated finding. PURPOSE: The aim of the present study was to investigate the genetics of idiopathic scoliosis in a Scandinavian cohort by performing a candidate gene study...... samples from 100 surgically treated idiopathic scoliosis patients. Novel or rare missense, nonsense, or splice site variants were selected for individual genotyping in the 1,739 cases and 1,812 controls. In addition, the 5'UTR, noncoding exon and promoter regions of LBX1, not covered by exome sequencing......, were Sanger sequenced in the 100 pooled samples. RESULTS: Of the four candidate genes, an intergenic variant, rs11190870, downstream of the LBX1 gene, showed a highly significant association to idiopathic scoliosis in 1,739 cases and 1,812 controls (p=7.0×10(-18)). We identified 20 novel variants...

  14. Downstream boundary effects on the frequency of self-excited oscillations in transonic diffuser flows

    Science.gov (United States)

    Hsieh, T.; Coakley, T. J.

    1987-01-01

    An investigation of downstream boundary effects on the frequency of self-excited oscillations in two-dimensional, separated transonic diffuser flows has been conducted numerically by solving the compressible, Reynolds-averaged, thin-layer Navier-Stokes equation with a two-equation turbulence model. It was found that the unsteady diffuser flowfields are very sensitive to the location of the downstream boundary. Extension of the diffuser downstream boundary significantly reduces the frequency and amplitude of oscillations for pressure, velocity and shock. Computational results suggest that the mechanism causing the self-excited oscillation changes from viscous convective wave dominated oscillations to inviscid acoustic wave dominated oscillations when the location of downstream boundary varies from 8.66 to 134.7 throat height. The existence of a suction slot in the experimental setup obscures the physical downstream boundary and, therefore, presents a difficulty for quantitative comparisons between computation and experiment.

  15. Experimental and analytical investigation of fan flow interaction with downstream struts

    Science.gov (United States)

    Olsen, T. L.; Ng, W. F.; Obrien, W. F., Jr.

    1985-01-01

    An investigation which was designed to provide insight into the fundamental aspects of fan rotor-downstream strut interaction was undertaken. High response, miniature pressure transducers were embedded in the rotor blades of an experimental fan rig. Five downstream struts were placed at several downstream locations in the discharge flow annulus of the single-stage machine. Significant interaction of the rotor blade surface pressures with the flow disturbance produced by the downstream struts was measured. Several numerical procedures for calculating the quasi-steady rotor response due to downstream flow obstructions were developed. A preliminary comparison of experimental and calculated fluctuating blade pressures on the rotor blades shows general agreement between the experimental and calculated values.

  16. Amplified spontaneous emission spectrum at the output of a diode amplifier saturated by an input monochromatic wave

    Science.gov (United States)

    Bogatov, A. P.; Drakin, A. E.; D'yachkov, N. V.; Gushchik, T. I.

    2016-08-01

    Expressions for the amplitudes of amplified spontaneous emission waves in a diode amplifier near the frequency ω0 of a 'strong' input monochromatic wave have been derived in terms of a random function of a stationary Gaussian process. We have found expressions for the spectral density of the amplitudes and shown that, on the red side of the spectrum with respect to frequency ω0, spontaneous emission waves obtain additional nonlinear gain, induced by the strong wave, whereas on the blue side of the spectrum an additional loss is induced. Such behaviour of the amplitudes of amplified waves agrees with previous results.

  17. A Doherty Amplifier with Envelope Tracking Technique and DSP for High Efficiency

    Directory of Open Access Journals (Sweden)

    Ambar Saxena

    2012-01-01

    Full Text Available A Doherty amplifier employing input signal envelope tracking technique. In the amplifier, gate bias of peaking amplifier is controlled according to the magnitude of the envelope. The performance of the microwave Doherty amplifier has been compared with class AB amplifier. DSP is used to dynamically adjust the gate bias of the auxiliary (peaking amplifier at the rate of the signal envelope to obtain gain flatness. DSP is used as a digital predistortor to improve the overall linearity and efficiency.

  18. Design And Construction Of 300W Audio Power Amplifier For Classroom

    OpenAIRE

    Shune Lei Aung; Kyaw Soe Lwin and Hla Myo Tun

    2015-01-01

    Abstract This paper describes the design and construction of 300W audio power amplifier for classroom. In the construction of this amplifier microphone preamplifier tone preamplifier equalizer line amplifier output power amplifier and sound level indicator are included. The output power amplifier is designed as O.C.L system and constructed by using Class B among many types of amplifier classes. There are two types in O.C.L system quasi system and complementary system. Between them the comple...

  19. Hearing Aids and Personal Sound Amplifiers: Know the Difference

    Science.gov (United States)

    ... For Consumers Home For Consumers Consumer Updates Hearing Aids and Personal Sound Amplifiers: Know the Difference Share ... or use them as substitutes—for approved hearing aids. "Hearing aids and personal sound amplification products (PSAPS) ...

  20. 1.55 Micron High Peak Power Fiber Amplifier Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In this proposal, we propose to demonstrate and build a 1.55 micron single frequency high energy and high peak power fiber amplifier by developing an innovative...

  1. Magnetic Bearing Amplifier Output Power Filters for Flywheel Systems

    Science.gov (United States)

    Lebron-Velilla, Ramon C.; Jansen, Ralph H.; Palazzolo, Alan; Thomas, Erwin; Kascak, Peter E.; Birchenough, Arthur G.; Dever, Timothy P.

    2003-01-01

    Five power filters and two types of power amplifiers were tested for use with active magnetic bearings for flywheel applications. Filter topologies included low pass filters and low pass filters combined with trap filters at the PWM switching frequency. Two state and three state PWM amplifiers were compared. Each system was evaluated based on current magnitude at the switching frequency, voltage magnitude at 500 kHz, and power consumption. The base line system was a two state amplifier without a power filter. The recommended system is a three state power amplifier with a 50 kHz low pass filter and a 27 kHz trap filter. This system uses 5.57 W. It reduces the switching current by an order of magnitude and the 500 kHz voltage by two orders of magnitude. The relative power consumption varied depending on the test condition between 60 to 130 percent of the baseline.

  2. High current density nanofilament cathodes for microwave amplifiers

    NARCIS (Netherlands)

    Schnell, J-P.; Minoux, E.; Gangloff, L.; Vincent, P.; Legagneux, P.; Dieumegard, D.; David, J.-F.; Peauger, F.; Hudanski, L.; Teo, K.B.K.; Lacerda, R.; Chhowalla, M.; Hasko, D.G.; Ahmed, H.; Amaratunga, G.A.J.; Milne, W.I.; Vila, L.; Dauginet-De Pra, L.; Demoustier-Champagne, S.; Ferain, E.; Legras, R.; Piraux, L.; Gröening, O.; Raedt, H. De; Michielsen, K.

    2004-01-01

    We study high current density nanofilament cathodes for microwave amplifiers. Two different types of aligned nanofilament array have been studied: first, metallic nanowires grown by electrodeposition into nanoporous templates at very low temperature (T

  3. Linear and nonlinear analysis of high-power rf amplifiers

    International Nuclear Information System (INIS)

    After a survey of the state variable analysis method the final amplifier for the CBA is analyzed taking into account the real beam waveshape. An empirical method for checking the stability of a non-linear system is also considered

  4. Experimental examinations of semiconductor laser amplifiers for optical communication technology

    Science.gov (United States)

    Ludwig, Reinhold

    1993-01-01

    Properties of SLA (Semiconductor Laser Amplifier), which are particularly interesting for application to linear repeaters in coherent multichannel systems, are studied and design rules for future optimized amplifier structure are deduced. Laser diode antireflection was examined and reflection factor was measured. Low signal properties were discussed considering injection current, wavelengths, temperature and polarization. The coupling between amplifiers and glass fibers was examined. The utilization of cascade amplifiers as linear repeaters in multichannel heterodyne systems and television distribution systems was investigatied. The following results are obtained: measurement and calculation of the paradiaphony between two signals radiated in a SLA; multichannel data transfer through a SLA; polarization independent amplification with SLA configurations; measurement of the frequency dependence of four wave mixing sidelines in a SLA; measurement of the system degradation through echoes in a bidirectional SLA chain; data transmission with frequency conversion and calculation of multichannel transmission systems with cascade SLA, taking into account saturation, signal to noise ratio, bandwidth reduction and echo.

  5. Gain Variation with Raman Amplifier Parameters and Its Restoration

    Institute of Scientific and Technical Information of China (English)

    Zhaohui Li; Chao Lu; Jian Chen

    2003-01-01

    We demonstrate that gain profile of a distributed Raman amplifier is sensitive to its parameter variation, such as loss/gain coefficients change or partial pump failure. Gain flatness can be restored by adjusting power of pump lasers.

  6. Fiber amplifiers under thermal loads leading to transverse mode instability

    DEFF Research Database (Denmark)

    Johansen, Mette Marie; Hansen, Kristian Rymann; Alkeskjold, Thomas Tanggaard;

    2014-01-01

    Transverse mode instability (TMI) in rare-earth doped fiber amplifiers operating above an average power threshold is caused by intermodal stimulated thermal Rayleigh scattering due to quantum defect heating. We investigate thermally induced longitudinal waveguide perturbations causing power trans...

  7. On the unlimited gain of a nonlinear parametric amplifier

    DEFF Research Database (Denmark)

    Sorokin, Vladislav

    2014-01-01

    The present paper is concerned with analysis of the response of a nonlinear parametric amplifier in abroad range of system parameters, particularly beyond resonance. Such analysis is of particular interestfor micro- and nanosystems, since many small-scale parametric amplifiers exhibit a distinctly...... nonlinearbehavior when amplitude of their response is sufficiently large. The modified method of direct separa-tion of motions is employed to study the considered system. As the result it is obtained that steady-stateamplitude of the nonlinear parametric amplifier response can reach large values in the case...... of arbitrarilysmall amplitude of external excitation, so that the amplifier gain tends to infinity. Very large amplifiergain can be achieved in a broad range of system parameters, in particular when the amplitude of para-metric excitation is comparatively small. The obtained results clearly demonstrate that very...

  8. Compression of chirp pulses from a femtosecond fiber based amplifier

    Science.gov (United States)

    Ito, Rumi; Takiuchi, Ken-ichi; Tei, Kazuyoku; Yamaguchi, Shigeru; Enokidani, Jyun; Sumida, Shin

    2015-03-01

    We demonstrate a single mode fiber based master oscillator power amplifier (MOPA) with a single polarization and a fully monolithic design. We have built a passive mode-locked polarization maintaining Yb doped fiber as the master oscillator contains a semiconductor saturable absorber mirror and a chirped fiber Bragg grating for the dispersion management. The net intracavity dispersion was managed to be slightly anomalous. The oscillator generates the 150 fs (sech2) pulses at the center wavelength of 1065 nm, and the repetition rate of 42 MHz. The oscillator output was amplified to 1.4 W from 80 mW in the single stage fiber amplifier which results in pulse shape distortion. The pulse shaping with a band pass filter and a compressor was applied to the amplified pulses. The shaping pulses have the pulse width of 90 fs and the pulse energy of 16 nJ.

  9. Nanofiber adsorbents for high productivity continuous downstream processing.

    Science.gov (United States)

    Hardick, Oliver; Dods, Stewart; Stevens, Bob; Bracewell, Daniel G

    2015-11-10

    An ever increasing focus is being placed on the manufacturing costs of biotherapeutics. The drive towards continuous processing offers one opportunity to address these costs through the advantages it offers. Continuous operation presents opportunities for real-time process monitoring and automated control with potential benefits including predictable product specification, reduced labour costs, and integration with other continuous processes. Specifically to chromatographic operations continuous processing presents an opportunity to use expensive media more efficiently while reducing their size and therefore cost. Here for the first time we show how a new adsorbent material (cellulosic nanofibers) having advantageous convective mass transfer properties can be combined with a high frequency simulated moving bed (SMB) design to provide superior productivity in a simple bioseparation. Electrospun polymeric nanofiber adsorbents offer an alternative ligand support surface for bioseparations. Their non-woven fiber structure with diameters in the sub-micron range creates a remarkably high surface area material that allows for rapid convective flow operations. A proof of concept study demonstrated the performance of an anion exchange nanofiber adsorbent based on criteria including flow and mass transfer properties, binding capacity, reproducibility and life-cycle performance. Binding capacities of the DEAE adsorbents were demonstrated to be 10mg/mL, this is indeed only a fraction of what is achievable from porous bead resins but in combination with a very high flowrate, the productivity of the nanofiber system is shown to be significant. Suitable packing into a flow distribution device has allowed for reproducible bind-elute operations at flowrates of 2,400 cm/h, many times greater than those used in typical beaded systems. These characteristics make them ideal candidates for operation in continuous chromatography systems. A SMB system was developed and optimised to

  10. Thermally induced nonlinear mode coupling in high power fiber amplifiers

    DEFF Research Database (Denmark)

    Johansen, Mette Marie; Hansen, Kristian Rymann; Alkeskjold, Thomas T.;

    2013-01-01

    Thermally induced nonlinear mode coupling leads to transverse mode instability (TMI) in high power fiber amplifiers. A numerical model including altering mode profiles from thermal effects and waveguide perturbations predicts a TMI threshold of ~200W.......Thermally induced nonlinear mode coupling leads to transverse mode instability (TMI) in high power fiber amplifiers. A numerical model including altering mode profiles from thermal effects and waveguide perturbations predicts a TMI threshold of ~200W....

  11. Calibration setup for ultralow-current transresistance amplifiers

    CERN Document Server

    Finardi, Ilaria

    2016-01-01

    We describe a calibration setup for the transresistance of low-current amplifiers, based on the capacitance-charging method. The calibration can be performed in the current range of typical interest for electron counting experiments. The setup implementation is simple and rugged, and is suitable to be embedded in larger experiments where the amplifier is employed. The calibration is traceable to units of capacitance and of time. The base relative accuracy of the implementation is in the 10^-5 range.

  12. Distributed Mode Filtering Rod Fiber Amplifier With Improved Mode Stability

    DEFF Research Database (Denmark)

    Laurila, Marko; Alkeskjold, Thomas Tanggaard; Broeng, Jes;

    2012-01-01

    We report 216W of average output power from a photonic crystal rod fiber amplifier. We demonstrate 44% power improvement before onset of the mode instability by operating the rod fiber in a leaky guiding regime.......We report 216W of average output power from a photonic crystal rod fiber amplifier. We demonstrate 44% power improvement before onset of the mode instability by operating the rod fiber in a leaky guiding regime....

  13. Ultrafast optical signal processing using semiconductor quantum dot amplifiers

    DEFF Research Database (Denmark)

    Berg, Tommy Winther; Mørk, Jesper

    2002-01-01

    The linear and nonlinear properties of quantum dot amplifiers are discussed on the basis of an extensive theoretical model. These devices show great potential for linear amplification as well as ultrafast signal processing.......The linear and nonlinear properties of quantum dot amplifiers are discussed on the basis of an extensive theoretical model. These devices show great potential for linear amplification as well as ultrafast signal processing....

  14. On the effect of time delays in negative feedback amplifiers

    OpenAIRE

    Alves, L. N.; Aguiar, R. L.

    2005-01-01

    Time delays are intrinsic to all existing devices and circuits. For the majority of applications, time delays are so small that their effects can be disregarded. However, when considering feedback amplifiers, depending on open-loop poles and loop gain, the effect of a small time delay inside the feedback path may turn to be of considerable importance. This paper analyzes the frequency response effects associated with time delays in feedback amplifiers, exploiting these effects to achieve band...

  15. On the dual symmetry between absorbing and amplifying random media

    Indian Academy of Sciences (India)

    S Anantha Ramakrishna

    2004-06-01

    We re-examine the dual symmetry between absorbing and amplifying random media. By analysing the physically allowed choice of the sign of the square root to determine the complex wave vector in a medium, we draw a broad set of conclusions that enables us to resolve the apparent paradox of the dual symmetry and also to anticipate the large local electromagnetic field enhancements in amplifying random media.

  16. DESIGN OF SEQUENTIALLY FED BALANCED AMPLIFYING ANTENNA FOR CIRCULAR POLARIZATION

    OpenAIRE

    S. K. Behera; D. R. Poddar; Mishra, R K

    2010-01-01

    This paper presents a sequentially fed balanced amplifying antenna that exhibits circularly polarized radiation. The inherent benefits of good isolation between input and output ports as well as improved matching capabilities of balanced amplifiers provide overall system gain of 8 dBi at frequency 2.36GHz. The planar arrangement of the patch antenna elements are considered to form an array. The phase of the feeding in the array increases progressively from 00 to 2700.Each element in the array...

  17. Optical parametric amplifier pumped by two mutually incoherent laser beams

    Science.gov (United States)

    Tamošauskas, G.; Dubietis, A.; Valiulis, G.; Piskarskas, A.

    2008-05-01

    We report on the experimental proof-of-principle demonstration of the ultrashort pulse single-pass beta-barium borate, BBO optical parametric amplifier pumped by two mutually incoherent laser sources. We show that the amplified signal at 1054 nm gains energy from both pump pulses with wavelengths of 680 and 527 nm, respectively, with overall energy conversion of 36%, and exhibits low wavefront distortions and improved energy stability in the gain saturation regime.

  18. Thermal Effects in High-Power Fiber Amplifiers

    DEFF Research Database (Denmark)

    Hansen, Kristian Rymann; Lægsgaard, Jesper

    2011-01-01

    The effect of temperature gradients in Yb-doped fiber amplifiers is studied numerically. We investigate the dependence of the mode area on the signal power, and compare forward and backward pumping schemes.......The effect of temperature gradients in Yb-doped fiber amplifiers is studied numerically. We investigate the dependence of the mode area on the signal power, and compare forward and backward pumping schemes....

  19. An amplifier for VUV photomultiplier operating in cryogenic environment

    Science.gov (United States)

    Arneodo, F.; Benabderrahmane, M. L.; Dahal, S.; Di Giovanni, A.; d`Inzeo, M.; Franchi, G.; Pazos Clemens, L.

    2016-07-01

    We present the characterisation of an amplifier potentially interesting for noble liquid detectors. The design has been conceived considering the requirements of low power consumption (less than 30 mW), low noise, amplification factor of 10 at 100 MHz and use of commercial components. The amplifier has been integrated onto an electronic board with a voltage divider to operate an Hamamatsu R11410 photomultiplier tube (used in XENON1T, Aprile et al. (2014) [1] dark matter experiment).

  20. Behavioral modeling and linearization of RF power amplifiers

    CERN Document Server

    Wood, John

    2014-01-01

    Wireless voice and data communications have made great improvements, with connectivity now virtually ubiquitous. Users are demanding essentially perfect transmission and reception of voice and data. The infrastructure that supports this wide connectivity and nearly error-free delivery of information is complex, costly, and continually being improved.This resource describes the mathematical methods and practical implementations of linearization techniques for RF power amplifiers for mobile communications. This includes a review of RF power amplifier design for high efficiency operation. Readers

  1. Design of low noise transimpedance amplifier for intravascular ultrasound

    KAUST Repository

    Reda, Dina

    2009-11-01

    In this paper, we study transimpedance amplifiers for capacitive sensing applications with a focus on Intravascular Ultra Sound (IVUS). We employ RF noise cancellation technique on capacitive feedback based transimpedance amplifiers. This technique eliminates the input-referred noise of TIAs completely and enhances the dynamic range of front-end electronics. Simulation results verify the proposed technique used in two different TIA topologies employing shunt-shunt feedback. ©2009 IEEE.

  2. Ferrite bead effect on Class-D amplifier audio quality

    OpenAIRE

    Haddad, Kevin El; Mrad, Roberto; Morel, Florent; Pillonnet, Gael; Vollaire, Christian; Nagari, Angelo

    2014-01-01

    International audience This paper studies the effect of ferrite beads on the audio quality of Class-D audio amplifiers. This latter is a switch-ing circuit which creates high frequency harmonics. Generally, a filter is used at the amplifier output for the sake of electro-magnetic compatibility (EMC). So often, in integrated solutions, this filter contains ferrite beads which are magnetic components and present nonlinear behavior. Time domain measurements and their equivalence in frequency ...

  3. Characterization of a multimode coplanar waveguide parametric amplifier

    Energy Technology Data Exchange (ETDEWEB)

    Simoen, M., E-mail: simoen@chalmers.se; Krantz, P.; Bylander, Jonas; Shumeiko, V.; Delsing, P. [Department of Microtechnology and Nanoscience (MC2), Chalmers University of Technology, Göteborg SE-412 96 (Sweden); Chang, C. W. S.; Wilson, C. M. [Institute for Quantum Computing and Department of Electrical and Computer Engineering, University of Waterloo, Waterloo, Ontario N2L 3G1 (Canada); Wustmann, W. [Department of Microtechnology and Nanoscience (MC2), Chalmers University of Technology, Göteborg SE-412 96 (Sweden); Laboratory for Physical Sciences, College Park, Maryland 20740 (United States)

    2015-10-21

    We characterize a Josephson parametric amplifier based on a flux-tunable quarter-wavelength resonator. The fundamental resonance frequency is ∼1 GHz, but we use higher modes of the resonator for our measurements. An on-chip tuning line allows for magnetic flux pumping of the amplifier. We investigate and compare degenerate parametric amplification, involving a single mode, and nondegenerate parametric amplification, using a pair of modes. We show that we reach quantum-limited noise performance in both cases.

  4. Investigation of two candidate genes for Hailey-Hailey disease

    Energy Technology Data Exchange (ETDEWEB)

    Peluso, A.M.; Ikeda, S.; Bonifas, J.M. [Univ. of California, San Francisco, CA (United States)] [and others

    1994-09-01

    Hailey-Hailey disease (familial benign chronic pemphigus) is an autosomal dominant skin disease characterized by impaired keratinocyte cohesion and consequent blister formation. Recently we have used linkage to map the gene for this disease to a region of chromosome 3q between D3S1589 and D3S1316. The maximum combined two point lod score in four families studied was 14.60 at {theta} = 0 at the D3S1290 microsatellite repeat. Several genes have been mapped to chromosome 3q21-24, including cellular retinol binding protein (RBP1) and rhodopsin (RHO). Using microsatellite repeat for RHO we have found a recombinant with the RHO gene and Hailey-Hailey disease in one patient. Because of the profound effects of retinoids on epidermal differentiation, RBP1 could be considered as a possible candidate gene. We have amplified genomic DNA from patients from 14 individual families with Hailey-Hailey disease and 10 different control samples for each of the 4 exons of RBP1. Thus far, SSCP analysis has failed to detect different banding patterns in patients versus controls. We are now attempting to extend this RBP1 analysis and are collecting new families to use linkage analysis to narrow this still rather large (approximately 14 cM) interval.

  5. Design And Construction Of 300W Audio Power Amplifier For Classroom

    Directory of Open Access Journals (Sweden)

    Shune Lei Aung

    2015-07-01

    Full Text Available Abstract This paper describes the design and construction of 300W audio power amplifier for classroom. In the construction of this amplifier microphone preamplifier tone preamplifier equalizer line amplifier output power amplifier and sound level indicator are included. The output power amplifier is designed as O.C.L system and constructed by using Class B among many types of amplifier classes. There are two types in O.C.L system quasi system and complementary system. Between them the complementary system is used in the construction of 300W audio power amplifier. The Multisim software is utilized for the construction of audio power amplifier.

  6. ANALYSIS OF INTERNALLY GENERATED NOISE OF BIOELECTRIC AMPLIFIERS

    Institute of Scientific and Technical Information of China (English)

    MashhourMustafaBaniAmer

    2003-01-01

    This papenr deals with internally generated noise of bioelectric amplifiers that are usually used for processing of bioelectric events.The main purpose of this paper is to present a procedure for analysis of the effects of internal noise generated by the active circuits and to evaluate the output noise of the author's new designed bioelectric amplifier that caused by internal effects to the amplifier circuit itself in order to compare it with the noise generated by conventional amplifiers.The obtained analysis results of internally generated noise showed that the total output noise of bioelectric active circuits does not increase when some of their resitors have a larger value.This behavior is caused by the different transfer functions for the signal and the respective noise sources associated with these resistors.Moreover,the new designed bioelectric amplifier haws an output noise less than that for conventional amplifiers.The obtained analysis results were also experimentally verified and the final conclusions were drawn.

  7. Frequency-Offset Cartesian Feedback Based on Polyphase Difference Amplifiers.

    Science.gov (United States)

    Zanchi, Marta G; Pauly, John M; Scott, Greig C

    2010-05-01

    A modified Cartesian feedback method called "frequency-offset Cartesian feedback" and based on polyphase difference amplifiers is described that significantly reduces the problems associated with quadrature errors and DC-offsets in classic Cartesian feedback power amplifier control systems.In this method, the reference input and feedback signals are down-converted and compared at a low intermediate frequency (IF) instead of at DC. The polyphase difference amplifiers create a complex control bandwidth centered at this low IF, which is typically offset from DC by 200-1500 kHz. Consequently, the loop gain peak does not overlap DC where voltage offsets, drift, and local oscillator leakage create errors. Moreover, quadrature mismatch errors are significantly attenuated in the control bandwidth. Since the polyphase amplifiers selectively amplify the complex signals characterized by a +90° phase relationship representing positive frequency signals, the control system operates somewhat like single sideband (SSB) modulation. However, the approach still allows the same modulation bandwidth control as classic Cartesian feedback.In this paper, the behavior of the polyphase difference amplifier is described through both the results of simulations, based on a theoretical analysis of their architecture, and experiments. We then describe our first printed circuit board prototype of a frequency-offset Cartesian feedback transmitter and its performance in open and closed loop configuration. This approach should be especially useful in magnetic resonance imaging transmit array systems. PMID:20814450

  8. Coherence optimization of vertical-cavity semiconductor optical amplifiers

    Science.gov (United States)

    Sanchez, Michael; Wen, Pengyue; Gross, Matthias; Kibar, Osman; Esener, Sadik C.

    2002-06-01

    Vertical cavity semiconductor optical amplifiers (VCSOAs) are attractive devices for use in coherent optical amplification, especially where 2-D amplifier arrays are required. However, the coherence preservation quality of a VCSOA depends strongly on the bias condition, resonant wavelength mismatch, and the optical input power level. We characterize the coherence degree of a VCSOA as a function of these parameters by measuring interference fringe visibility with an interferometer. The dominant factors influencing the contrast of the fringes are the ratio of coherent, stimulated emission photons to amplified spontaneous emission (ASE) photons, and the spectral distortion of the amplified signal. Mostly, the overall gain and the saturation characteristic of the amplifier determine the ratio of stimulated emission to ASE. The spectral distortion of the signal is due to the narrow gain window of the VCSOA, but the effect significantly degrades the visibility only for relatively large wavelength mismatch from the gain peak. Analytic expressions may be used to identify the optimal bias current and optical input power to maximize the amplifier gain and visibility of the interference.

  9. Improving Students' Understanding of Lock-In Amplifiers

    Science.gov (United States)

    DeVore, Seth; Gauthier, Alexandre; Levy, Jeremy; Chandralekha, Singh

    2014-03-01

    A lock-in amplifier is a versatile instrument frequently used in physics research. However, many students struggle with the basic operating principles of a lock-in amplifier which can lead to a variety of difficulties. To improve students' understanding, we have been developing and evaluating a research-based tutorial which makes use of a computer simulation of a lock-in amplifier. The tutorial is based on a field-tested approach in which students realize their difficulties after predicting the outcome of simulated experiments involving a lock-in amplifier and check their predictions using the simulated lock-in amplifier. Then, the tutorial guides and helps students develop a coherent understanding of the basics of a lock-in amplifier. The tutorial development involved interviews with physics faculty members and graduate students and iteration of many versions of the tutorial with professors and graduate students. The student difficulties and the development and assessment of the research-based tutorial are discussed. We thank National Science Foundation for award NSF-1124131.

  10. Improving Students' Understanding of Lock-in Amplifiers

    CERN Document Server

    DeVore, Seth; Levy, Jeremy; Singh, Chandralekha

    2016-01-01

    A lock-in amplifier is a versatile instrument frequently used in physics research. However, many students struggle with the basic operating principles of a lock-in amplifier which can lead to a variety of difficulties. To improve students' understanding, we have been developing and evaluating a research-based tutorial which makes use of a computer simulation of a lock-in amplifier. The tutorial is based on a field-tested approach in which students realize their difficulties after predicting the outcome of simulated experiments involving a lock-in amplifier and check their predictions using the simulated lock-in amplifier. Then, the tutorial guides and helps students develop a coherent understanding of the basics of a lock-in amplifier. The tutorial development involved interviews with physics faculty members and graduate students and iteration of many versions of the tutorial with professors and graduate students. The student difficulties and the development and assessment of the research-based tutorial are d...

  11. Bioinformatics methods for identifying candidate disease genes

    NARCIS (Netherlands)

    Driel, M.A. van; Brunner, H.G.

    2006-01-01

    With the explosion in genomic and functional genomics information, methods for disease gene identification are rapidly evolving. Databases are now essential to the process of selecting candidate disease genes. Combining positional information with disease characteristics and functional information i

  12. Cattle Candidate Genes for Milk Production Traits

    OpenAIRE

    Kadlec, Tomáš

    2012-01-01

    The aim of this thesis is to make an overview of important candidate genes affecting milk yield and milk quality parameters, with an emphasis on genes associated with the quantity and quality of milk proteins and milk fat.

  13. Evaluating historical candidate genes for schizophrenia

    DEFF Research Database (Denmark)

    Farrell, M S; Werge, T; Sklar, P;

    2015-01-01

    Prior to the genome-wide association era, candidate gene studies were a major approach in schizophrenia genetics. In this invited review, we consider the current status of 25 historical candidate genes for schizophrenia (for example, COMT, DISC1, DTNBP1 and NRG1). The initial study for 24...... of these genes explicitly evaluated common variant hypotheses about schizophrenia. Our evaluation included a meta-analysis of the candidate gene literature, incorporation of the results of the largest genomic study yet published for schizophrenia, ratings from informed researchers who have published...... on these genes, and ratings from 24 schizophrenia geneticists. On the basis of current empirical evidence and mostly consensual assessments of informed opinion, it appears that the historical candidate gene literature did not yield clear insights into the genetic basis of schizophrenia. A likely reason why...

  14. Towards Treating Chemistry Teacher Candidates as Human

    Science.gov (United States)

    Lewthwaite, Brian Ellis

    2008-05-01

    This research inquiry investigates the factors influencing chemistry teacher candidates’ development during their extended practica in the second and final year of an After-Degree Bachelor of Education at a university in central Canada. A variety of data sources are used to identify the risk and protective factors impeding and contributing to the achievement of their chemistry pedagogical aspirations. Two theoretical frameworks, both having their origins in the pioneering work of Kurt Lewin, are used to conceptualize how a complex amalgam of personal attribute and environmental factors and the interplay among these factors influence teacher candidate developmental trajectories. The tenets of both Bronfenbrenner’s bioecological model and Learning Environment research provide insights into how the factors influencing teacher candidate development can be understood and systematically documented to provide a template for reflective consideration of the practicum experience for both teacher candidates and those involved in fostering the development of chemistry teacher candidates.

  15. Do People 'Like' Candidates on Facebook?

    DEFF Research Database (Denmark)

    Nielsen, Rasmus Kleis

    The online popularity of a few exceptional candidates has led many to suggest that social media have given politicians powerful ways of communicating directly with voters. In this paper, we examine whether this is happening on a significant scale and show, based on analysis of 224 candidates....... We therefore suggest that the political implications of social media are generally better understood in terms of facilitating indirect communication and institutional change than in terms of direct communication....

  16. Candidal Leukoplakia on Patient with Removable Denture

    OpenAIRE

    Shiril Paskalis; Anandina Irmagita

    2013-01-01

    Candida infection is a common problem in patients using removable dentures, with the most frequent type is denture stomatitis. But other type of candidal infection could also happen in these patients, such as candidal leukoplakia. We reported a 61 years old female patient who complained a painful lesion under her lower removable denture. Oral examination revealed white plaque that could not be rubbed over an ulcer on the lingual part of alveolar processes under the lower removable denture pla...

  17. Comparison of small scale methods for the rapid and efficient extraction of mitochondrial DNA from wheat crop suitable for down-stream processes.

    Science.gov (United States)

    Ejaz, M; Gaisheng, Z; Na, N; Huiyan, Z; Qidi, Z; Qunzhu, W

    2014-12-04

    We evaluated and compared 2 mitochondrial DNA (mtDNA) extraction methods in terms of DNA quality and success of subsequent polymerase chain reaction (PCR) amplifications from yellow etiolated shoots of wheat crop (Triticum aestivum). mtDNA ex-traction is difficult because the presence of metabolites interfere with DNA isolation procedures and downstream applications such as DNA restriction, amplification, and cloning. The method (with modification) involved inactivation of genomic DNA by DNase I enzyme, RNA by RNase enzyme, contaminant proteins by using proteinase K, and precipitation of polysaccharides in the presence of a high salt concentration. The DNase I and RNA enzyme ratio was adjusted to 10:8 mL. The purity of mtDNA was confirmed by PCR amplification of genomic, mitochondrial, and chloroplast (rbcL) gene. The mitochondrial COXIII gene of 400 bp was amplified; the b-actin and chloroplast genes were not amplified. A260/A280 (1.89) and A260/A230 (2.07) ratios were calculated using a spectrophotometer. The isolated mtDNA was amenable to amplification and restriction digestion. The technique is fast, reproducible, and suitable for PCR-based markers.

  18. Cardiac evaluation of liver transplant candidates

    Institute of Scientific and Technical Information of China (English)

    Mercedes Susan Mandell; JoAnn Lindenfeld; Mei-Yung Tsou; Michael Zimmerman

    2008-01-01

    Physicians previously thought that heart disease was rare in patients with end stage liver disease. However, recent evidence shows that the prevalence of ischemic heart disease and cardiomyopathy is increased in transplant candidates compared to most other surgical candidates. Investigators estimate that up to 26% of all liver transplant candidates have at least one critical coronary artery stenosis and that at least half of these patients will die perioperatively of cardiac complications. Cardiomyopathy also occurs in greater frequency. While all patients with advanced cardiac disease have defects in cardiac performance, a larger than expected number of patients have classical findings of dilated, restrictive and hypertropic cardiomyopathy. This may explain why up to 56% of patients suffer from hypoxemia due to pulmonary edema following transplant surgery. There is considerable controversy on how to screen transplant candidates for the presence of heart disease. Questions focus upon, which patients should be screened and what tests should be used. This review examines screening strategies for transplant candidates and details the prognostic value of common tests used to identify ischemic heart disease. We also review the physiological consequences of cardiomyopathy in transplant candidates and explore the specific syndrome of "cirrhotic cardiomyopathy".

  19. Mapping of five candidate sex-determining loci in rainbow trout (Oncorhynchus mykiss

    Directory of Open Access Journals (Sweden)

    Drew Robert E

    2009-01-01

    Full Text Available Abstract Background Rainbow trout have an XX/XY genetic mechanism of sex determination where males are the heterogametic sex. The homology of the sex-determining gene (SDG in medaka to Dmrt1 suggested that SDGs evolve from downstream genes by gene duplication. Orthologous sequences of the major genes of the mammalian sex determination pathway have been reported in the rainbow trout but the map position for the majority of these genes has not been assigned. Results Five loci of four candidate genes (Amh, Dax1, Dmrt1 and Sox6 were tested for linkage to the Y chromosome of rainbow trout. We exclude the role of all these loci as candidates for the primary SDG in this species. Sox6i and Sox6ii, duplicated copies of Sox6, mapped to homeologous linkage groups 10 and 18 respectively. Genotyping fishes of the OSU × Arlee mapping family for Sox6i and Sox6ii alleles indicated that Sox6i locus might be deleted in the Arlee lineage. Conclusion Additional candidate genes should be tested for their linkage to the Y chromosome. Mapping data of duplicated Sox6 loci supports previously suggested homeology between linkage groups 10 and 18. Enrichment of the rainbow trout genomic map with known gene markers allows map comparisons with other salmonids. Mapping of candidate sex-determining loci is important for analyses of potential autosomal modifiers of sex-determination in rainbow trout.

  20. Downstream Antisense Transcription Predicts Genomic Features That Define the Specific Chromatin Environment at Mammalian Promoters

    Science.gov (United States)

    Lavender, Christopher A.; Hoffman, Jackson A.; Trotter, Kevin W.; Gilchrist, Daniel A.; Bennett, Brian D.; Burkholder, Adam B.; Fargo, David C.; Archer, Trevor K.

    2016-01-01

    Antisense transcription is a prevalent feature at mammalian promoters. Previous studies have primarily focused on antisense transcription initiating upstream of genes. Here, we characterize promoter-proximal antisense transcription downstream of gene transcription starts sites in human breast cancer cells, investigating the genomic context of downstream antisense transcription. We find extensive correlations between antisense transcription and features associated with the chromatin environment at gene promoters. Antisense transcription downstream of promoters is widespread, with antisense transcription initiation observed within 2 kb of 28% of gene transcription start sites. Antisense transcription initiates between nucleosomes regularly positioned downstream of these promoters. The nucleosomes between gene and downstream antisense transcription start sites carry histone modifications associated with active promoters, such as H3K4me3 and H3K27ac. This region is bound by chromatin remodeling and histone modifying complexes including SWI/SNF subunits and HDACs, suggesting that antisense transcription or resulting RNA transcripts contribute to the creation and maintenance of a promoter-associated chromatin environment. Downstream antisense transcription overlays additional regulatory features, such as transcription factor binding, DNA accessibility, and the downstream edge of promoter-associated CpG islands. These features suggest an important role for antisense transcription in the regulation of gene expression and the maintenance of a promoter-associated chromatin environment. PMID:27487356

  1. Downstream Antisense Transcription Predicts Genomic Features That Define the Specific Chromatin Environment at Mammalian Promoters.

    Science.gov (United States)

    Lavender, Christopher A; Cannady, Kimberly R; Hoffman, Jackson A; Trotter, Kevin W; Gilchrist, Daniel A; Bennett, Brian D; Burkholder, Adam B; Burd, Craig J; Fargo, David C; Archer, Trevor K

    2016-08-01

    Antisense transcription is a prevalent feature at mammalian promoters. Previous studies have primarily focused on antisense transcription initiating upstream of genes. Here, we characterize promoter-proximal antisense transcription downstream of gene transcription starts sites in human breast cancer cells, investigating the genomic context of downstream antisense transcription. We find extensive correlations between antisense transcription and features associated with the chromatin environment at gene promoters. Antisense transcription downstream of promoters is widespread, with antisense transcription initiation observed within 2 kb of 28% of gene transcription start sites. Antisense transcription initiates between nucleosomes regularly positioned downstream of these promoters. The nucleosomes between gene and downstream antisense transcription start sites carry histone modifications associated with active promoters, such as H3K4me3 and H3K27ac. This region is bound by chromatin remodeling and histone modifying complexes including SWI/SNF subunits and HDACs, suggesting that antisense transcription or resulting RNA transcripts contribute to the creation and maintenance of a promoter-associated chromatin environment. Downstream antisense transcription overlays additional regulatory features, such as transcription factor binding, DNA accessibility, and the downstream edge of promoter-associated CpG islands. These features suggest an important role for antisense transcription in the regulation of gene expression and the maintenance of a promoter-associated chromatin environment. PMID:27487356

  2. Downstream channel adjustment in a low-relief, glacially conditioned watershed

    Science.gov (United States)

    Thayer, James B.; Phillips, Roger T. J.; Desloges, Joseph R.

    2016-06-01

    River management practices are often informed by theoretical expectations of downstream channel adjustment, which may not be valid in low relief, glacially conditioned watersheds such as those in the lower North American Great Lakes region. Downstream trends in channel morphology and bed material size within a low-relief, glacially conditioned watershed are explored here and compared to a theoretical watershed model where slope and grain size are expected to decline exponentially. The observed channel morphology is then tested against a theoretical concept of reach-scale channel grade. The downstream hydraulic geometry relations wbf ∝ Qbf0.51S- 0.02 and dbf ∝ Qbf0.32S- 0.21 were found to best describe downstream changes in channel morphology and are consistent with some prior studies. Bed material size varies irregularly down the channel. Slope-controlled downstream fining trends are evident where inputs from glacial materials and tributaries are negligible but are masked by cobble/boulder lag deposits where the channel is cut into these glacial deposits. The asynchronous variability in slope and grain size produces downstream variations in graded and nongraded, understeepened conditions separated at τ*ex = 0. Graded reaches exist where τ*ex > 0, but an upper boundary with nongraded, oversteepened reaches is less clear. The results emphasize the geomorphic legacy of inherited slopes and sediment sources in dictating the modern downstream patterns of fluvial characteristics and morphologies in glacially conditioned, and similarly complex, watersheds.

  3. Mercury exposure in terrestrial birds far downstream of an historical point source

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, Allyson K., E-mail: allyson.jackson@briloon.org [Biodiversity Research Institute, 19 Flaggy Meadow Road, Gorham, ME 04038 (United States); Institute for Integrative Bird Behavior Studies, Department of Biology, College of William and Mary, PO Box 8795, Williamsburg, VA 23187 (United States); Evers, David C.; Folsom, Sarah B. [Biodiversity Research Institute, 19 Flaggy Meadow Road, Gorham, ME 04038 (United States); Condon, Anne M. [U.S. Fish and Wildlife Service, 6669 Short Lane, Gloucester, VA 23061 (United States); Diener, John; Goodrick, Lizzie F. [Biodiversity Research Institute, 19 Flaggy Meadow Road, Gorham, ME 04038 (United States); McGann, Andrew J. [Institute for Integrative Bird Behavior Studies, Department of Biology, College of William and Mary, PO Box 8795, Williamsburg, VA 23187 (United States); Schmerfeld, John [U.S. Fish and Wildlife Service, 6669 Short Lane, Gloucester, VA 23061 (United States); Cristol, Daniel A. [Institute for Integrative Bird Behavior Studies, Department of Biology, College of William and Mary, PO Box 8795, Williamsburg, VA 23187 (United States)

    2011-12-15

    Mercury (Hg) is a persistent environmental contaminant found in many freshwater and marine ecosystems. Historical Hg contamination in rivers can impact the surrounding terrestrial ecosystem, but there is little known about how far downstream this contamination persists. In 2009, we sampled terrestrial forest songbirds at five floodplain sites up to 137 km downstream of an historical source of Hg along the South and South Fork Shenandoah Rivers (Virginia, USA). We found that blood total Hg concentrations remained elevated over the entire sampling area and there was little evidence of decline with distance. While it is well known that Hg is a pervasive and long-lasting aquatic contaminant, it has only been recently recognized that it also biomagnifies effectively in floodplain forest food webs. This study extends the area of concern for terrestrial habitats near contaminated rivers for more than 100 km downstream from a waterborne Hg point source. - Highlights: > We report blood mercury levels for terrestrial songbirds downstream of contamination. > Blood mercury levels remain elevated above reference for at least 137 km downstream. > Trends vary based on foraging guild and migration strategy. > Mercury affects terrestrial biota farther downstream than previously documented. - Blood mercury levels of forest songbirds remain elevated above reference levels for at least 137 km downstream of historical point source.

  4. Measurement of velocity deficit at the downstream of a 1:10 axial hydrokinetic turbine model

    Energy Technology Data Exchange (ETDEWEB)

    Gunawan, Budi [ORNL; Neary, Vincent S [ORNL; Hill, Craig [St. Anthony Falls Laboratory, 2 Third Avenue SE, Minneapolis, MN 55414; Chamorro, Leonardo [St. Anthony Falls Laboratory, 2 Third Avenue SE, Minneapolis, MN 55414

    2012-01-01

    Wake recovery constrains the downstream spacing and density of turbines that can be deployed in turbine farms and limits the amount of energy that can be produced at a hydrokinetic energy site. This study investigates the wake recovery at the downstream of a 1:10 axial flow turbine model using a pulse-to-pulse coherent Acoustic Doppler Profiler (ADP). In addition, turbine inflow and outflow velocities were measured for calculating the thrust on the turbine. The result shows that the depth-averaged longitudinal velocity recovers to 97% of the inflow velocity at 35 turbine diameter (D) downstream of the turbine.

  5. Rare Earth Doped Fiber Amplifiers for the First Telecommunication Window

    Science.gov (United States)

    Sridhar, Balakrishnan

    A complete experimental and theoretical study of rare earth doped fiber-optic amplifiers for the first tele-communication window has been made. The thulium doped fluoride fiber amplifier is shown to provide amplification in the 800nm-820nm signal region. A complete steady state theoretical model has been presented and the model has been experimentally verified. The model predicts the gain, noise figure and the amplified spontaneous emission in the 800nm, 1470nm, 1900nm and 2300nm bands. The effect of population trapping at the ^3F_4 energy level of thulium ion is also shown with the help of the model. It has been shown that about 5 -15%o of the population is trapped at the ^3F _4 energy level. We have also shown theoretically, the expected gain and noise performance of Thulium doped fluoride fiber amplifiers pumped in the 680nm absorption band. The maximum gain at 806nm is slightly lower than with comparable 780 nm pumping. The gain bandwidth is however found to increase with 680nm pumping. The higher ASE at shorter wavelengths (flouride fiber amplifier in the 850nm signal band for the first time. The amplification is through an up-conversion process. The erbium doped flouride fiber amplifier was pumped with an estimated pump power of 35mW at 792nm. We have also considered a theoretical model for a single mode erbium doped fluoride fiber amplifier. Efficient amplification occurs because of the strong excited state absorption at the pump wavelength from the ^4I_{13/2} energy level.

  6. Theoretical and numerical treatment of modal instability in high-power core and cladding-pumped Raman fiber amplifiers.

    Science.gov (United States)

    Naderi, Shadi; Dajani, Iyad; Grosek, Jacob; Madden, Timothy

    2016-07-25

    Raman fiber lasers have been proposed as potential candidates for scaling beyond the power limitations imposed on near diffraction-limited rare-earth doped fiber lasers. One limitation is the modal instability (MI) and we explore the physics of this phenomenon in Raman fiber amplifiers (RFAs). By utilizing the conservation of number of photons and conservation of energy in the absence of loss, the 3 × 3 governing system of nonlinear equations describing the pump and the signal modal content are decoupled and solved analytically for cladding-pumped RFAs. By comparing the extracted signal at MI threshold for the same step index-fiber, it is found that the MI threshold is independent of the length of the amplifier or whether the amplifier is co-pumped or counter-pumped; dictated by the integrated heat load along the length of fiber. We extend our treatment to gain-tailored RFAs and show that this approach is of limited utility in suppressing MI. Finally, we formulate the physics of MI in core-pumped RFAs where both pump and signal interferences participate in writing the time-dependent index of refraction grating. PMID:27464110

  7. Downstream energetic proton and alpha particles during quasi-parallel interplanetary shock events

    Science.gov (United States)

    Tan, L. C.; Mason, G. M.; Gloeckler, G.; Ipavich, F. M.

    1988-01-01

    This paper considers the energetic particle populations in the downstream region of three quasi-parallel interplanetary shock events, which was explored using the ISEE 3 Ultra Low Energy Charge Analyzer sensor, which unambiguously identifies protons and alpha particles using the electrostatic deflection versus residual energy technique. The downstream particles were found to exhibit anisotropies due largely to convection in the solar wind. The spectral indices of the proton and the alpha-particle distribution functions were found to be remarkably constant during the downstream period, being generally insensitive to changes in particle flux levels, magnetic field direction, and solar wind densities. In two of the three events, the proton and the alpha spectra were the same throughout the entire downstream period, supporting the prediction of diffusive shock acceleration theory.

  8. Downstream movement of recently transformed sea lampreys, Petromyzon marinus, in Carp Lake River, Michigan

    Science.gov (United States)

    Applegate, Vernon C.; Brynildson, Clifford L.

    1951-01-01

    In order to obtain more precise information concerning the downstream movement of recently transformed sea lampreys, a trapping device was operated in the Carp Lake River, Emmet County, Michigan, from October, 1948, to July, 1951.

  9. Design of A Microwave Amplifier for Wireless Application

    Directory of Open Access Journals (Sweden)

    M. H. Ullah

    2012-01-01

    Full Text Available Problem statement: Low-Noise Amplifiers (LNA are very indispensable components in the design of numerous types of communication receivers employed in microwave technology. This paper is presents the design and development of low bias(Vce = 8v, Ic =10 mA single stage low noise microwave amplifier operating in 1.5GHZ frequency range, Gain 13dB ± 0.5dB, input/output return loss Approach: The principal design target is to obtain a minimum noise figure while concomitantly achieving a maximum gain by presenting the optimum noise impedance (Zopt which is characteristically implemented by adding a matching circuit between the source and the input of the amplifier. Results: The proposed low-noise amplifier for microwave wireless application is designed, simulated and optimized using Serenade Harmonica (by Ansoft Corporation and Advance Design System (ADS software by Agilent. Conclusion: In this paper a low-noise amplifier operated at 1.5 GHz. is designed because of the significant roles played in the field of microwave communication technology, which includes the application in the output stage of a transmitter where the signals needs to be strengthen before transmission.

  10. Residual phase noise modeling of amplifiers using silicon bipolar transistors.

    Science.gov (United States)

    Theodoropoulos, Konstantinos; Everard, Jeremy

    2010-03-01

    In this paper, we describe the modeling of residual 1/f phase noise for Si bipolar amplifiers operating in the linear region. We propose that for Si bipolar amplifiers, the 1/f phase noise is largely caused by the base emitter recombination flicker noise. The up-conversion mechanism is described through linear approximation of the phase variation of the amplifier phase response by the variation of the device parameters (C(b)c, C(be), g(m), r(e)) caused by the recombination 1/f noise. The amplifier phase response describes the device over the whole frequency range of operation for which the influence of the poles and zeros is investigated. It is found that for a common emitter amplifier it is sufficient to only incorporate the effect of the device poles to describe the phase noise behavior over most of its operational frequency range. Simulations predict the measurements of others, including the flattening of the PM noise at frequencies beyond f(3dB), not predicted by previous models.

  11. A fully integrated neural recording amplifier with DC input stabilization.

    Science.gov (United States)

    Mohseni, Pedram; Najafi, Khalil

    2004-05-01

    This paper presents a low-power low-noise fully integrated bandpass operational amplifier for a variety of biomedical neural recording applications. A standard two-stage CMOS amplifier in a closed-loop resistive feedback configuration provides a stable ac gain of 39.3 dB at 1 kHz. A subthreshold PMOS input transistor is utilized to clamp the large and random dc open circuit potentials that normally exist at the electrode-electrolyte interface. The low cutoff frequency of the amplifier is programmable up to 50 Hz, while its high cutoff frequency is measured to be 9.1 kHz. The tolerable dc input range is measured to be at least +/- 0.25 V with a dc rejection factor of at least 29 dB. The amplifier occupies 0.107 mm2 in die area, and dissipates 115 microW from a 3 V power supply. The total measured input-referred noise voltage in the frequency range of 0.1-10 kHz is 7.8 microVrms. It is fabricated using AMI 1.5 microm double-poly double-metal n-well CMOS process. This paper presents full characterization of the dc, ac, and noise performance of this amplifier through in vitro measurements in saline using two different neural recording electrodes. PMID:15132510

  12. Power neodymium-glass amplifier of a repetitively pulsed laser

    Energy Technology Data Exchange (ETDEWEB)

    Vinogradov, Aleksandr V; Gaganov, V E; Garanin, Sergey G; Zhidkov, N V; Krotov, V A; Martynenko, S P; Pozdnyakov, E V; Solomatin, I I [Russian Federal Nuclear Center ' All-Russian Research Institute of Experimental Physics' , Sarov, Nizhnii Novgorod region (Russian Federation)

    2011-11-30

    A neodymium-glass diode-pumped amplifier with a zigzag laser beam propagation through the active medium was elaborated; the amplifier is intended for operation in a repetitively pulsed laser. An amplifier unit with an aperture of 20 Multiplication-Sign 25 mm and a {approx}40-cm long active medium was put to a test. The energy of pump radiation amounts to 140 J at a wavelength of 806 nm for a pump duration of 550 {mu}s. The energy parameters of the amplifier were experimentally determined: the small-signal gain per pass {approx}3.2, the linear gain {approx}0.031 cm{sup -1} with a nonuniformity of its distribution over the aperture within 15%, the stored energy of 0.16 - 0.21 J cm{sup -3}. The wavefront distortions in the zigzag laser-beam propagation through the active element of the amplifier did not exceed 0.4{lambda} ({lambda} = 0.63 {mu}m is the probing radiation wavelength).

  13. Design and development of digital seismic amplifier recorder

    Energy Technology Data Exchange (ETDEWEB)

    Samsidar, Siti Alaa; Afuar, Waldy; Handayani, Gunawan, E-mail: gunawanhandayani@gmail.com [Department of Physics, ITB (Indonesia)

    2015-04-16

    A digital seismic recording is a recording technique of seismic data in digital systems. This method is more convenient because it is more accurate than other methods of seismic recorders. To improve the quality of the results of seismic measurements, the signal needs to be amplified to obtain better subsurface images. The purpose of this study is to improve the accuracy of measurement by amplifying the input signal. We use seismic sensors/geophones with a frequency of 4.5 Hz. The signal is amplified by means of 12 units of non-inverting amplifier. The non-inverting amplifier using IC 741 with the resistor values 1KΩ and 1MΩ. The amplification results were 1,000 times. The results of signal amplification converted into digital by using the Analog Digital Converter (ADC). Quantitative analysis in this study was performed using the software Lab VIEW 8.6. The Lab VIEW 8.6 program was used to control the ADC. The results of qualitative analysis showed that the seismic conditioning can produce a large output, so that the data obtained is better than conventional data. This application can be used for geophysical methods that have low input voltage such as microtremor application.

  14. Low input voltage switching amplifiers for piezoelectric actuators

    Science.gov (United States)

    Lindner, Douglas K.; Zhu, Huiyu; Song, Chunping; Huang, Weixing; Cheng, Danling

    2002-07-01

    The Inertially Stabilized Rifle is a new stabilized rifle system that can eliminate the disturbances induced by the shooter. Recurve actuator is used in this system to provide the precise movement of the rifle barrel. In such a portable device, only low voltage electrical sources are available yet the piezoelectric actuator needs high voltage to drive the actuator. The actuators consume little real power but a large amount of reactive power. Furthermore, the piezoelectric actuators are present an almost purely capacitive load. In this paper, we describe the development of a low input voltage amplifier for a high voltage piezoelectric actuator. This amplifier is based on switching technology so it efficiently handles the regenerative energy from the piezoelectric actuator. This amplifier consists of two stages. The first stage is a flyback converter which boosts the (low) input voltage to the maximum voltage required by the piezoelectric actuator. The second stage is a half-bridge amplifier which delivers the output voltage to the actuator as commanded by the reference signal. The basic structure of the amplifier is described, and its performance is characterized in terms of bandwidth, distortion, and efficiency.

  15. Spectroscopic amplifier for pin diode; Amplificador espectroscopico para diodo Pin

    Energy Technology Data Exchange (ETDEWEB)

    Alonso M, M. S.; Hernandez D, V. M.; Vega C, H. R., E-mail: bebe.luna_s@hotmail.com [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas (Mexico)

    2014-10-15

    The photodiode remains the basic choice for the photo-detection and is widely used in optical communications, medical diagnostics and field of corpuscular radiation. In detecting radiation it has been used for monitoring radon and its progeny and inexpensive spectrometric systems. The development of a spectroscopic amplifier for Pin diode is presented which has the following characteristics: canceler Pole-Zero (P/Z) with a time constant of 8 μs; constant gain of 57, suitable for the acquisition system; 4th integrator Gaussian order to waveform change of exponential input to semi-Gaussian output and finally a stage of baseline restorer which prevents Dc signal contribution to the next stage. The operational amplifier used is the TLE2074 of BiFET technology of Texas Instruments with 10 MHz bandwidth, 25 V/μs of slew rate and a noise floor of 17 nv/(Hz)1/2. The integrated circuit has 4 operational amplifiers and in is contained the total of spectroscopic amplifier that is the goal of electronic design. The results show like the exponential input signal is converted to semi-Gaussian, modifying only the amplitude according to the specifications in the design. The total system is formed by the detector, which is the Pin diode, a sensitive preamplifier to the load, the spectroscopic amplifier that is what is presented and finally a pulse height analyzer (Mca) which is where the spectrum is shown. (Author)

  16. Ways to suppress click and pop for class D amplifiers

    Science.gov (United States)

    Haishi, Wang; Bo, Zhang; Jiang, Sun

    2012-08-01

    Undesirable audio click and pop may be generated in a speaker or headphone. Compared to linear (class A/B/AB) amplifiers, class D amplifiers that comprise of an input stage and a modulation stage are more prone to producing click and pop. This article analyzes sources that generate click and pop in class D amplifiers, and corresponding ways to suppress them. For a class D amplifier with a single-ended input, click and pop is likely to be due to two factors. One is from a voltage difference (VDIF) between the voltage of an input capacitance (VCIN) and a reference voltage (VREF) of the input stage, and the other one is from the non-linear switching during the setting up of the bias and feedback voltages/currents (BFVC) of the modulation stage. In this article, a fast charging loop is introduced into the input stage to charge VCIN to roughly near VREF. Then a correction loop further charges or discharges VCIN, substantially equalizing it with VREF. Dummy switches are introduced into the modulation stage to provide switching signals for setting up BFVC, and the power switches are disabled until the BFVC are set up successfully. A two channel single-ended class D amplifier with the above features is fabricated with 0.5 μm Bi-CMOS process. Road test and fast Fourier transform analysis indicate that there is no noticeable click and pop.

  17. Particle acceleration by combined diffusive shock acceleration and downstream multiple magnetic island acceleration

    Science.gov (United States)

    Zank, G. P.; Hunana, P.; Mostafavi, P.; le Roux, J. A.; Li, Gang; Webb, G. M.; Khabarova, O.

    2015-09-01

    As a consequence of the evolutionary conditions [28; 29], shock waves can generate high levels of downstream vortical turbulence. Simulations [32-34] and observations [30; 31] support the idea that downstream magnetic islands (also called plasmoids or flux ropes) result from the interaction of shocks with upstream turbulence. Zank et al. [18] speculated that a combination of diffusive shock acceleration (DSA) and downstream reconnection-related effects associated with the dynamical evolution of a “sea of magnetic islands” would result in the energization of charged particles. Here, we utilize the transport theory [18; 19] for charged particles propagating diffusively in a turbulent region filled with contracting and reconnecting plasmoids and small-scale current sheets to investigate a combined DSA and downstream multiple magnetic island charged particle acceleration mechanism. We consider separately the effects of the anti-reconnection electric field that is a consequence of magnetic island merging [17], and magnetic island contraction [14]. For the merging plasmoid reconnection- induced electric field only, we find i) that the particle spectrum is a power law in particle speed, flatter than that derived from conventional DSA theory, and ii) that the solution is constant downstream of the shock. For downstream plasmoid contraction only, we find that i) the accelerated particle spectrum is a power law in particle speed, flatter than that derived from conventional DSA theory; ii) for a given energy, the particle intensity peaks downstream of the shock, and the peak location occurs further downstream of the shock with increasing particle energy, and iii) the particle intensity amplification for a particular particle energy, f(x, c/c0)/f(0, c/c0), is not 1, as predicted by DSA theory, but increases with increasing particle energy. These predictions can be tested against observations of electrons and ions accelerated at interplanetary shocks and the heliospheric

  18. Temporal progression in migratory status and sexual maturation in European silver eels during downstream migration

    OpenAIRE

    Arjan P Palstra; Guerrero, Ma Angeles; de Laak, Gerard; Klein Breteler, Jan P. G.; Guido E E J M van den Thillart

    2011-01-01

    The onset of downstream migration of European eels is accompanied by a cessation of feeding and the start of sexual maturation which stresses the link between metabolism and sexual maturation, also suggesting an important role for exercise. Exercise has been tested with eels in swim tunnels and was found to stimulate the onset of sexual maturation. In this study, we have investigated the interplay between migration and maturation in the field during the downstream migration of female silver e...

  19. Stable isotopes reveal food web modifications along the upstream-downstream gradient of a temperate stream

    OpenAIRE

    Hette-Tronquart, N.; Belliard, J.; Tales, E.; Oberdorff, Thierry

    2016-01-01

    The upstream-downstream gradient (UDG) is a key feature of streams. For instance food webs are assumed to change from upstream to downstream. We tested this hypothesis in a small European river catchment (937 km(2)), and examined whether food web modifications are related to structural (i.e. food web composition) or functional changes (i.e. alteration of linkages within the web). We adopted a double approach at two levels of organisation (assemblage and species levels) using two isotopic metr...

  20. Bioactive Carbohydrates and Peptides in Foods: An Overview of Sources, Downstream Processing Steps and Associated Bioactivities.

    Science.gov (United States)

    Hayes, Maria; Tiwari, Brijesh K

    2015-01-01

    Bioactive peptides and carbohydrates are sourced from a myriad of plant, animal and insects and have huge potential for use as food ingredients and pharmaceuticals. However, downstream processing bottlenecks hinder the potential use of these natural bioactive compounds and add cost to production processes. This review discusses the health benefits and bioactivities associated with peptides and carbohydrates of natural origin and downstream processing methodologies and novel processes which may be used to overcome these.

  1. User experience network. Erroneous downstream occlusion alarms may disable Smiths Medical CADD-Solis infusion pumps.

    Science.gov (United States)

    2010-10-01

    Due to an issue in manufacturing, downstream occlusion (DSO) sensors in some Smiths Medical CADD-Solis infusion pumps may drift out of calibration, potentially resulting in erroneous alarms that disable the units. Hospitals experiencing the problem should return affected units to Smiths Medical for recalibration (free of charge) and should consider testing all their CADD-Solis pumps during routine maintenance to ensure that they alarm appropriately for downstream occlusions.

  2. Entrepreneurial orientation and the threat of imitation: the influence of upstream and downstream capabilities

    OpenAIRE

    García-Villaverde, P.M.; Ruiz-Ortega, M.J.; Canales, J.I.

    2013-01-01

    This paper uncovers the complexity between Entrepreneurial Orientation (EO) and performance. The paper explores the effect of the threat of imitation, which is a key external factor to explain competitive dynamics, and hence highlights effectiveness of EO. Also the paper accounts for the role of upstream (technical) and downstream (marketing) capabilities as they influence effectiveness of EO. Our results show that, under threat of imitation, downstream marketing capabilities facilitate tapin...

  3. Photoperiod control of downstream movements of Atlantic salmon Salmo salar smolts.

    Science.gov (United States)

    Zydlewski, G B; Stich, D S; McCormick, S D

    2014-10-01

    This study provides the first direct observations that photoperiod controls the initiation of downstream movement in Atlantic salmon Salmo salar smolts. Under simulated natural day length (LDN) conditions and seasonal increases in temperature, smolts increased their downstream movements five-fold for a period of 1 month in late spring. Under the same conditions, parr did not show changes in downstream movement behaviour. When given a shortened day length (10L:14D) beginning in late winter, smolts did not increase the number of downstream movements. An early increase in day length (16L:8D) in late winter resulted in earlier initiation and termination of downstream movements compared to the LDN group. Physiological status and behaviour were related but not completely coincident: gill Na(+) /K(+) -ATPase activity increased in all treatments and thyroid hormone was elevated prior to movement in 16L:8D treatment. The most parsimonious model describing downstream movement of smolts included synergistic effects of photoperiod treatment and temperature, indicating that peak movements occurred at colder temperatures in the 16L:8D treatment than in LDN, and temperature did not influence movement of smolts in the 10L:14D treatment. The complicated interactions of photoperiod and temperature are not surprising since many organisms have evolved to rely on correlations among environmental cues and windows of opportunity to time behaviours associated with life-history transitions. These complicated interactions, however, have serious implications for phenological adjustments and persistence of S. salar populations in response to climate change. PMID:25263186

  4. Josephson traveling-wave parametric amplifier for superconducting qubit readout

    Science.gov (United States)

    Macklin, Chris; Slichter, D. H.; Yaakobi, O.; Friedland, L.; Bolkhovsky, V.; Braje, D. A.; Fitch, G.; Oliver, W. D.; Siddiqi, I.

    2014-03-01

    Superconducting parametric amplifiers (paramps) have successfully demonstrated near quantum limited sensitivity, enabling single-shot qubit readout, feedback, and state tracking. However, these amplifiers are commonly limited to narrow bandwidth and modest dynamic range, and most require microwave circulators to separate input and output modes. These limitations stem from the use of a resonant non-linearity to achieve mixing between a signal and pump mode. Our traveling-wave parametric amplifier (TWPA) is based on a superconducting nonlinear Josephson junction transmission line, thereby inherently sidestepping the limitations associated with a cavity structure. We present theoretical predictions and experimental results, including improved gain and noise performance. We discuss transmon qubit readout in the circuit QED architecture using a TWPA. We also comment on promising architectures for chip-level integration and multiplexing. Work supported by IARPA.

  5. Spectrally tailored supercontinuum generation from single-mode-fiber amplifiers

    Energy Technology Data Exchange (ETDEWEB)

    Hao, Qiang; Guo, Zhengru; Zhang, Qingshan [Shanghai Key Laboratory of Modern Optical System, Engineering Research Center of Optical Instrument and System (Ministry of Education), School of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093 (China); Liu, Yang; Li, Wenxue [State Key Laboratory of Precision Spectroscopy, East China Normal University, 3663 Zhongshan North Road, Shanghai 200062 (China); Zeng, Heping, E-mail: hpzeng@phy.ecnu.edu.cn [Shanghai Key Laboratory of Modern Optical System, Engineering Research Center of Optical Instrument and System (Ministry of Education), School of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093 (China); State Key Laboratory of Precision Spectroscopy, East China Normal University, 3663 Zhongshan North Road, Shanghai 200062 (China)

    2014-05-19

    Spectral filtering of an all-normal-dispersion Yb-doped fiber laser was demonstrated effective for broadband supercontinuum generation in the picosecond time region. The picosecond pump pulses were tailored in spectrum with 1 nm band-pass filter installed between two single-mode fiber amplifiers. By tuning the spectral filter around 1028 nm, four-wave mixing was initiated in a photonic crystal fiber spliced with single-mode fiber, as manifested by the simultaneous generation of Stokes wave at 1076 nm and anti-Stokes wave at 984 nm. Four-wave mixing took place in cascade with the influence of stimulated Raman scattering and eventually extended the output spectrum more than 900 nm of 10 dB bandwidth. This technique allows smooth octave supercontinuum generation by using simple single-mode fiber amplifiers rather than complicated multistage large-mode-area fiber amplifiers.

  6. Beam intensity reshaping by pump modification in a laser amplifier.

    Science.gov (United States)

    Litvin, Igor A; Collet, Oliver J P; King, Gary; Strauss, Hencharl

    2015-11-16

    We propose a new technique for laser beam shaping into a desirable beam profile by using a laser amplifier with a pump beam that has a modified intensity profile. We developed the analytical formula, which describes the transformation of the seed beam into the desired beam profile in a four level amplifiers small signal regime. We propose a numerically method to obtain the required pump intensity profile in the case where high pump power saturated the laser crystal or for three level materials. The theory was experimentally verified by one dimensionally shaping a Gaussian shaped seed into a Flat-Top beam in a Ho:YLF amplifier pumped by a Tm:YLF laser with a HG(01) intensity profile. PMID:26698497

  7. Modal instabilities in very large mode area rod fiber amplifiers

    DEFF Research Database (Denmark)

    Jørgensen, Mette Marie; Hansen, Kristian Rymann; Laurila, Marko;

    Optical fiber amplifiers have gained increased scientific and commercial interest due to high output powers with easy operation and maintenance. The main advantages of fiber amplifiers are good thermal properties, due to a large surface/volume ratio, excellent beam quality and stability [1]. Very...... large core fiber areas are highly desirable to mitigate various nonlinear processes, such as Kerr, four-wave mixing, Raman, and Brillouin effects. It is difficult to scale up the core area without going into a multi-moded regime. Microstructured fiber technology has allowed core diameters of 60...... with the finite element method to allow complex micro structured fibers to be considered. Thereby the modal instability threshold is estimated for very large mode area fiber amplifiers of various photonic crystal fiber designs. Experimentally the modal instability threshold for very large mode area fiber...

  8. Modeling Distortion Effects in Class-D Amplifier Filter Inductors

    DEFF Research Database (Denmark)

    Knott, Arnold; Stegenborg-Andersen, Tore; Thomsen, Ole Cornelius;

    2010-01-01

    Distortion is generally accepted as a quantifier to judge the quality of audio power amplifiers. In switchmode power amplifiers various mechanisms influence this performance measure. After giving an overview of those, this paper focuses on the particular effect of the nonlinearity of the output...... filter components on the audio performance. While the physical reasons for both, the capacitor and the inductor induced distortion are given, the practical in depth demonstration is done for the inductor only. This includes measuring the inductors performance, modeling through fitting and resulting...... into simulation models. The fitted models achieve distortion values between 0.03 % and 0.2 % as a basis to enable the design of a 200 W amplifier....

  9. Fiber optical parametric amplifiers in optical communication systems

    DEFF Research Database (Denmark)

    Marhic, Michel E.; Andrekson, Peter A.; Petropoulos, Periklis;

    2015-01-01

    The prospects for using fiber optical parametric amplifiers (OPAs) in optical communication systems are reviewed. Phase-insensitive amplifiers (PIAs) and phase-sensitive amplifiers (PSAs) are considered. Low-penalty amplification at/or near 1 Tb/s has been achieved, for both wavelength- and time......-division multiplexed formats. High-quality mid-span spectral inversion has been demonstrated at 0.64 Tb/s, avoiding electronic dispersion compensation. All-optical amplitude regeneration of amplitude-modulated signals has been performed, while PSAs have been used to demonstrate phase regeneration of phase...... in excess of 14,000 Tb/s x km in realistic wavelength-division multiplexed long-haul networks. Technical challenges remaining to be addressed in order for fiber OPAs to become useful for long-haul communication networks are discussed....

  10. Theoretical Analysis of Rayleigh Backscattering Noise in Fiber Raman Amplifiers

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    In this paper, a new theoretical model for Rayleigh backscattering (RB) analysis of fiber Raman amplifiers is proposed. The model includes all the interactions among the pumps, signals, and all orders of RB. The results show that the higher order RB has a negligible influence on the performance of the amplifier. The co-propagating and counterpropagating RB power of the signal grow quadratically with the net-gain of the amplifier. The signal to double Rayleigh backscattering noise ratio (OSNRDRB ) of backward-pumped FRAs is better than that of the forward-pumped ones at high net-gain level (> 13 dB), while at low net-gain level the OSNRDrb of the forward-pumped FRAs is slightly better than that of the backward-pumped ones.

  11. Using MEMS Capacitive Switches in Tunable RF Amplifiers

    Directory of Open Access Journals (Sweden)

    Danson John

    2006-01-01

    Full Text Available A MEMS capacitive switch suitable for use in tunable RF amplifiers is described. A MEMS switch is designed, fabricated, and characterized with physical and RF measurements for inclusion in simulations. Using the MEMS switch models, a dual-band low-noise amplifier (LNA operating at GHz and GHz, and a tunable power amplifier (PA at GHz are simulated in m CMOS. MEMS switches allow the LNA to operate with 11 dB of isolation between the two bands while maintaining dB of gain and sub- dB noise figure. MEMS switches are used to implement a variable matching network that allows the PA to realize up to 37% PAE improvement at low input powers.

  12. IMPATT power building blocks for 20 GHz spaceborne transmit amplifier

    Science.gov (United States)

    Asmus, J.; Cho, Y.; Degruyl, J.; Ng, E.; Giannakopoulos, A.; Okean, H. C.

    1982-01-01

    Single-stage circulator coupled IMPATT building block constituents of a 20-GHz solid state power amplifier (SSPA) currently under development for spaceborne downlink transmitter usage have been demonstrated as providing 1.5 to 2.0W RF power output at 4 to 5 dB operating gain over a 1 GHz bandwidth. Using either commercially available or recently developed in-house GaAs Schottky Read-profile IMPATT diodes, DC/RF power added efficiencies of 14 to 15% were achieved in these amplifier stages. A two stage IMPATT driver amplifier with similar RF output power capability exhibited 13 + or - 0.5 dB operating gain over a 1 GHz bandwidth.

  13. Cattle Candidate Genes for Meat Production Traits

    OpenAIRE

    Bláhová, Alice

    2013-01-01

    The objective of this study was to compile a summary of the most important candidate genes for meat production. The studied genes were: GH, GHR, MSTN, MyoD family, leptin, IGF, TG5, SCD, DGAT and STAT5A. Growth hormone (GH) is involved in physiological processes of growth and metabolism. Growth hormone receptor (GHR) has been proposed as a candidate gene for meat production in cattle. Myostatin is a significant marker. It affects the amount of muscle, reduces marbling and elevate meat tendern...

  14. Issue-Advocacy versus Candidate Advertising: Effects on Candidate Preferences and Democratic Process.

    Science.gov (United States)

    Pfau, Michael; Holbert, R. Lance; Szabo, Erin Alison; Kaminski, Kelly

    2002-01-01

    Examines the influence of soft-money-sponsored issue-advocacy advertising in U.S. House and Senate campaigns, comparing its effects against candidate-sponsored positive advertising and contrast advertising on viewers' candidate preferences and on their attitude that reflect democratic values. Reveals no main effects for advertising approach on…

  15. The design of a 4’th order Bandpass Butterworth filter with one operational amplifier

    DEFF Research Database (Denmark)

    Gaunholt, Hans

    2008-01-01

    band pass filter with Butterworth poles applying just one operational amplifier coupled as a unity gain amplifier. The unity gain amplifiers have the advantage of providing low power consumption, yielding a large dynamic range, sometimes simplifying the amplifier design and being usable over a larger...... frequency range than conventional constant gain amplifiers. The Schoeffler sensitivity index is used as a basis for a practical realization of the circuit....

  16. Thermal-recovery of modal instability in rod fiber amplifiers

    DEFF Research Database (Denmark)

    Jørgensen, Mette Marie; Laurila, Marko; Noordegraaf, Danny;

    2013-01-01

    We investigate the temporal dynamics of Modal instabilities (MI) in ROD fiber amplifiers using a 100 μm core rod fiber in a single-pass amplifier configuration, and we achieve ~200W of extracted output power before the onset of MI. Above the MI threshold, we investigate the temporal dynamics of b...... and thermally annealed between each test series. We find that the MI threshold degrades as it is reached multiple times, but is recovered by thermal annealing. We also find that the test history of the rods affects the temporal dynamics....

  17. Design of Low Noise Microwave Amplifiers Using Particle Swarm Optimization

    Directory of Open Access Journals (Sweden)

    Sadık Ulker

    2012-08-01

    Full Text Available This short paper presents a work on the design of low noise microwave amplifiers using particle swarmoptimization (PSO technique. Particle Swarm Optimization is used as a method that is applied to a singlestage amplifier circuit to meet two criteria: desired gain and desired low noise. The aim is to get the bestoptimized design using the predefined constraints for gain and low noise values. The code is written toapply the algorithm to meet the desired goals and the obtained results are verified using differentsimulators. The results obtained show that PSO can be applied very efficiently for this kind of designproblems with multiple constraints.

  18. Design of Low Noise Microwave Amplifiers Using Particle Swarm Optimization

    Directory of Open Access Journals (Sweden)

    Sadık Ülker

    2012-07-01

    Full Text Available This short paper presents a work on the design of low noise microwave amplifiers using particle swarm optimization (PSO technique. Particle Swarm Optimization is used as a method that is applied to a single stage amplifier circuit to meet two criteria: desired gain and desired low noise. The aim is to get the best optimized design using the predefined constraints for gain and low noise values. The code is written to apply the algorithm to meet the desired goals and the obtained results are verified using different simulators. The results obtained show that PSO can be applied very efficiently for this kind of design problems with multiple constraints.

  19. Dispersion-Engineered Traveling Wave Kinetic Inductance Parametric Amplifier

    Science.gov (United States)

    Zmuidzinas, Jonas (Inventor); Day, Peter K. (Inventor)

    2014-01-01

    A traveling wave kinetic inductance parametric amplifier comprises a superconducting transmission line and a dispersion control element. The transmission line can include periodic variations of its dimension along its length. The superconducting material can include a high normal state resistivity material. In some instances the high normal state resistivity material includes nitrogen and a metal selected from the group consisting of titanium, niobium and vanadium. The traveling wave kinetic inductance parametric amplifier is expected to exhibit a noise temperature below 100 mK/GHz.

  20. Investigation of accelerator's characteristics used for an energy amplifier

    International Nuclear Information System (INIS)

    The sub-critical reactor of the energy amplifier is a kind of swimming pool reactors, operates by fast neutron and uses ThO2 + 0.1U233 as fuel. The long cylindrical fuel bars are arranged in constant steps according to a hexagonal configuration. The two fuel assemblies are with the 12.43 mm and 11.38 mm fuel bar steps. The cell group parameters and effective neutron multiplication coefficient of the energy amplifier including two neutron energy groups are defined by the WIMS-D homogenization code. Their calculating results are presented. (NHA)

  1. High efficiency coherent beam combining of semiconductor optical amplifiers.

    Science.gov (United States)

    Creedon, Kevin J; Redmond, Shawn M; Smith, Gary M; Missaggia, Leo J; Connors, Michael K; Kansky, Jan E; Fan, Tso Yee; Turner, George W; Sanchez-Rubio, Antonio

    2012-12-01

    We demonstrate 40 W coherently combined output power in a single diffraction-limited beam from a one-dimensional 47-element array of angled-facet slab-coupled optical waveguide amplifiers at 1064 nm. The output from each emitter was collimated and overlapped onto a diffractive optical element combiner using a common transform lens. Phase locking was achieved via active feedback on each amplifier's drive current to maximize the power in the combined beam. The combining efficiency at all current levels was nearly constant at 87%.

  2. Resonant Phase Matching of Josephson Junction Traveling Wave Parametric Amplifiers

    Science.gov (United States)

    O'Brien, Kevin; Macklin, Chris; Siddiqi, Irfan; Zhang, Xiang

    2014-10-01

    We propose a technique to overcome phase mismatch in Josephson-junction traveling wave parametric amplifiers in order to achieve high gain over a broad bandwidth. Using "resonant phase matching," we design a compact superconducting device consisting of a transmission line with subwavelength resonant inclusions that simultaneously achieves a gain of 20 dB, an instantaneous bandwidth of 3 GHz, and a saturation power of -98 dBm. Such an amplifier is well suited to cryogenic broadband microwave measurements such as the multiplexed readout of quantum coherent circuits based on superconducting, semiconducting, or nanomechanical elements, as well as traditional astronomical detectors.

  3. In-amplifier mid-infrared supercontinuum generation.

    Science.gov (United States)

    Gauthier, Jean-Christophe; Fortin, Vincent; Duval, Simon; Vallée, Réal; Bernier, Martin

    2015-11-15

    Mid-infrared supercontinuum (SC) generation from 2.6 to 4.1 μm is demonstrated in a single-mode erbium-doped fluoride glass fiber amplifier pumped at 976 nm and seeded by an optical parametric generation (OPG) source emitting 400 ps pulses at 2.75 μm. Up to 82% of the SC power is generated beyond 3 μm. This novel and simple in-amplifier SC generation approach is promising for the development of compact and efficient sources operating in the mid-infrared, especially in the 3-5 μm band. PMID:26565846

  4. Solid-state microwave high-power amplifiers

    CERN Document Server

    Sechi, Franco

    2009-01-01

    This practical resource offers expert guidance on the most critical aspects of microwave power amplifier design. This comprehensive book provides descriptions of all the major active devices, discusses large signal characterization, explains all the key circuit design procedures. Moreover you gain keen insight on the link between design parameters and technological implementation, helping you achieve optimal solutions with the most efficient utilization of available technologies. The book covers a broad range of essential topics, from requirements for high-power amplifiers, device models, phas

  5. Accurate simulation of Raman amplified lightwave synthesized frequency sweeper

    DEFF Research Database (Denmark)

    Pedersen, Anders Tegtmeier; Olesen, Anders Sig; Rottwitt, Karsten

    2011-01-01

    A lightwave synthesized frequency sweeper using a Raman amplifier for loss compensation is presented together with a numerical model capable of predicting the shape of individual pulses as well as the overall envelope of more than 100 pulses. The generated pulse envelope consists of 116 pulses...... with constant peak power and no significant growth of noise. The numerical simulation is based on careful measurements of the physical properties of the individual components and a well established Raman amplifier model. Very good agreement between the measured and the simulated data is found. (C) 2011 Optical...

  6. Multislice behavioral modeling based on envelope domain for power amplifiers

    Institute of Scientific and Technical Information of China (English)

    Wang Huadong; Bao Jingfu; Wu Zhengde

    2009-01-01

    An envelope domain multislice behavioral modeling is introduced. The tradition AM-AM and AM-PM characteristics of power amplifiers are extended to envelope domain and base-band filter is applied to distortion complex envelope signal for description of the envelope memory effect. Using traditional one and two-tone tests, the coefficients of nonlinear model and the FIR filter can be extracted. At last the model has been applied to a 10 W WCDMA power amplifier to predict its output signal. And simulation results show that the model output conforms very well to the traditional transistor level simulation results.

  7. Four-wave mixing in nanosecond pulsed fiber amplifiers.

    Science.gov (United States)

    Fève, Jean-Philippe; Schrader, Paul E; Farrow, Roger L; Kliner, Dahv A V

    2007-04-16

    We present an experimental and theoretical analysis of four-wave mixing in nanosecond pulsed amplifiers based on double-clad ytterbium-doped fibers. This process leads to saturation of the amplified pulse energy at 1064 nm and to distortion of the spectral and temporal profiles. These behaviours are well described by a simple model considering both Raman and four-wave-mixing contributions. The role of seed laser polarization in birefringent fibers is also presented. These results point out the critical parameters and possible tradeoffs for optimization. PMID:19532710

  8. Tapered amplifier laser with frequency-shifted feedback

    CERN Document Server

    Bayerle, A; Vlaar, P; Pasquiou, B; Schreck, F

    2016-01-01

    We present a frequency-shifted feedback (FSF) laser based on a tapered amplifier. The laser operates as a coherent broadband source with up to 370GHz spectral width and 2.3us coherence time. If the FSF laser is seeded by a continuous-wave laser a frequency comb spanning the output spectrum appears in addition to the broadband emission. The laser has an output power of 280mW and a center wavelength of 780nm. The ease and flexibility of use of tapered amplifiers makes our FSF laser attractive for a wide range of applications, especially in metrology.

  9. DC SQUID amplifier for NMR experiments on small samples

    International Nuclear Information System (INIS)

    Low noise preamplifiers are required for the detection of the magnetic resonance of small size samples or at low magnetic fields. According to calculations based on the en, in model. SQUID based amplifiers are more suitable to NMR experiments on small samples than semiconductor amplifiers. We propose an amplification method by frequency transposition using a DC SQUID. Such a system can be run over a broad range of frequency as the noise impedance of the stages subsequent to the SQUID is continually optimised. The measurements are in good agreement with our theoretical model, based on a simplified voltage to flux SQUID characteristic. (orig.)

  10. Adaptation of a Digitally Predistorted RF Amplifier Using Selective Sampling

    Institute of Scientific and Technical Information of China (English)

    R. Neil Braithwaite

    2011-01-01

    In this paper, a reduced-cost method of measuring residual nonlinearities in an adaptive digitally predistorted amplifier is proposed. Measurements obtained by selective sampling of the amplifier output are integrated over the input envelope range to adapt a fourth-order polynomial predistorter with memory correction. Results for a WCDMA input with a 101 carrier configuration show that a transmitter using the proposed method can meet the adjacent channel leakage ratio (ACLR) specification. Inverse modeling of the nonlinearity is proposed as a future extension that will reduce the cost of the system further.

  11. High-power phase locking of a fiber amplifier array

    Science.gov (United States)

    Shay, T. M.; Baker, J. T.; Sanchez, A. D.; Robin, C. A.; Vergien, C. L.; Zeringue, C.; Gallant, D.; Lu, Chunte A.; Pulford, Benjamin; Bronder, T. J.; Lucero, Arthur

    2009-02-01

    We report high power phase locked fiber amplifier array using the Self-Synchronous Locking of Optical Coherence by Single-detector Electronic-frequency Tagging technique. We report the first experimental results for a five element amplifier array with a total locked power of more than 725-W. We will report on experimental measurements of the phase fluctuations versus time when the control loop is closed. The rms phase error was measured to be λ/60. Recent results will be reported. To the best of the authors' knowledge this is the highest fiber laser power to be coherently combined.

  12. Low-noise FET amplifier for dc SQUID

    International Nuclear Information System (INIS)

    We report on the design, characterization, and operation of a low-noise FET-input differential amplifier, which is used as second stage for a dc SQUID in the electronic instrumentation of the gravitational wave detector of the Rome group at CERN. The 3-dB bandwidth of the amplifier is from 10 kHz to 1.5 MHz. At the SQUID modulation frequency of 70 kHz the voltage noise is 0.5 nV/(Hz)1/2, the current noise is 35 fA/(Hz)1/2

  13. Gain dynamics and saturation in semiconductor quantum dot amplifiers

    DEFF Research Database (Denmark)

    Berg, Tommy Winther; Mørk, Jesper; Hvam, Jørn Märcher

    2004-01-01

    Quantum dot (QD)-based semiconductor optical amplifiers offer unique properties compared with conventional devices based on bulk or quantum well material. Due to the bandfilling properties of QDs and the existence of a nearby reservoir of carriers in the form of a wetting layer, QD semiconductor...... carrier populations in terms of a simple rate equation model. Based on the steady-state and small-signal properties of the model, we analyse and discuss the optical modulation response and the four-wave mixing properties of QD semiconductor optical amplifiers, in particular emphasizing the role...

  14. Spatial and spectral imaging of LMA photonic crystal fiber amplifiers

    DEFF Research Database (Denmark)

    Laurila, Marko; Lægsgaard, Jesper; Alkeskjold, Thomas Tanggaard;

    2011-01-01

    We demonstrate modal characterization using spatial and spectral resolved (S2) imaging, on an Ytterbium-doped large-mode-area photonic crystal fiber (PCF) amplifier and compare results with conventional cut-off methods. We apply numerical simulations and step-index fiber experiments to calibrate...... our mathematical and experimental routines of our S2 imaging system. We systematically analyze higher order mode (HOM) content of a polarizing 40μm core double-clad PCF amplifier with various launching and coiling configurations. We demonstrate a HOM suppression of more than -24dB with variance of 2...

  15. On Instantaneous Power Dissipation in Class B Amplifier

    Directory of Open Access Journals (Sweden)

    Hristo Zhivomirov

    2014-08-01

    Full Text Available The present paper describes the analysis of the instantaneous power dissipation by the two active components in a class B power amplifier. Attention is paid to restrictions of the instantaneous power dissipation relations in reference literature, and the consequences of their misuse. A new generalized equation that takes into account the power dissipated by the two active devices is proposed. The theoretical statement is substantiated by Matlab® numeric computation and visualization, Cadence OrCAD® simulations and measurements of a real-world audio power amplifier performed by NI USB-6211 measurement complex.

  16. Amplifier input impedance in dry electrode ECG recording.

    Science.gov (United States)

    Assambo, Cedric; Burke, Martin J

    2009-01-01

    This paper presents a novel approach for designing the front-end of instrumentation amplifiers for use in dry electrode recording of the human electrocardiogram (ECG). The method relies on information provided by the characterization of the skin-electrode interface and the analysis of low frequency ECG criteria defined by international standards. Marginal measurements of capacitive elements of the skin-electrode interface as small as 0.01 microF, suggest values of input impedance in the order of 1.3 GOmega. However, results in 99% of the data analyzed indicate that a recording amplifier providing an input impedance of 500 MOmega should ensure clear signal sensing without distortion.

  17. A Method To ModifyCorrect The Performance Of Amplifiers

    Directory of Open Access Journals (Sweden)

    Rohith Krishnan R

    2015-01-01

    Full Text Available Abstract The actual response of the amplifier may vary with the replacement of some aged or damaged components and this method is to compensate that problem. Here we use op-amp Fixator as the design tool. The tool helps us to isolate the selected circuit component from rest of the circuit adjust its operating point to correct the performance deviations and to modify the circuit without changing other parts of the circuit. A method to modifycorrect the performance of amplifiers by properly redesign the circuit is presented in this paper.

  18. Towards Treating Chemistry Teacher Candidates as Human

    Science.gov (United States)

    Lewthwaite, Brian Ellis

    2008-01-01

    This research inquiry investigates the factors influencing chemistry teacher candidates' development during their extended practica in the second and final year of an After-Degree Bachelor of Education at a university in central Canada. A variety of data sources are used to identify the risk and protective factors impeding and contributing to the…

  19. Spectroscopy of Hyades L dwarf candidates

    CERN Document Server

    Lodieu, N; Bejar, V J S

    2014-01-01

    We present the results of photometric, astrometric, and spectroscopic follow-up of L dwarf candidates identified in the Hyades cluster by Hogan et al. (2008). We obtained low-resolution optical spectroscopy with the OSIRIS spectrograph on the Gran Telescopio de Canarias for all 12 L dwarf candidates as well as new J-band imaging for a subsample of eight to confirm their proper motion. We also present mid-infrared photometry from the Wise Field Infrared Survey Explorer (WISE) for the Hyades L and T dwarf candidates and estimate their spectroscopic distances, effective temperatures, and masses. We confirm the cool nature of several L dwarf candidates and confirm astrometrically their membership, bridging the gap between the coolest M dwarfs and the two T dwarfs previously reported in the Hyades cluster. These members represent valuable spectral templates at an age of 625 Myr and slightly super solar metallicity (Fe/H=+0.13). We update the Hyades mass function across the hydrogen-burning limit and in the substel...

  20. 76 FR 36130 - Call for Candidates

    Science.gov (United States)

    2011-06-21

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ACCOUNTING STANDARDS ADVISORY BOARD Call for Candidates AGENCY: Federal Accounting Standards Advisory Board. ACTION: Request for... Accounting Standards Advisory Board (FASAB or the Board) with the requested materials in response to...

  1. 11 CFR 9003.2 - Candidate certifications.

    Science.gov (United States)

    2010-01-01

    ... excess of the aggregate payments to which they will be entitled under 11 CFR part 9004. (2) That no... funds under 11 CFR 9003.2(c)(3) shall not count against such candidate's $50,000 expenditure limitation... expenditures in excess of the limitations of 11 CFR 110.8(a), the Commission may seek civil penalties under...

  2. Emotional Intelligence and Beginning Teacher Candidates

    Science.gov (United States)

    Justice, Madeline; Espinoza, Sue

    2007-01-01

    According to the Bureau of Labor Statistics, Texas will need over 82,000 new teachers by 2008. Many teachers are leaving the profession within 5 years of being employed. Closing a revolving door, teacher preparation programs are discussing this phenomenon. One hundred sixty beginning teacher candidates were surveyed using the Emotional Skills…

  3. Fuzzy Treatment of Candidate Outliers in Measurements

    Directory of Open Access Journals (Sweden)

    Giampaolo E. D'Errico

    2012-01-01

    Full Text Available Robustness against the possible occurrence of outlying observations is critical to the performance of a measurement process. Open questions relevant to statistical testing for candidate outliers are reviewed. A novel fuzzy logic approach is developed and exemplified in a metrology context. A simulation procedure is presented and discussed by comparing fuzzy versus probabilistic models.

  4. Promoting Team Leadership Skills in Doctoral Candidates

    Science.gov (United States)

    Suleiman, Mahmoud; Whetton, Danny

    2014-01-01

    Doctoral programs can serve as an optimal opportunity for candidates to engage in tasks and activities to transform them and their schools. The paradigm shifts in such preparation involve moving from sitting and getting to making and taking. Most importantly, it requires building leadership skills and styles necessary to bring about desired change…

  5. Gallium-67 imaging in candidal esophagitis

    Energy Technology Data Exchange (ETDEWEB)

    Rundback, J.H.; Goldfarb, C.R.; Ongseng, F. (Beth Israel Medical Center, New York, NY (USA))

    1990-01-01

    Ga-67 scanning has been used to evaluate esophageal carcinoma. It has demonstrated candidal infection in other body sites and, in one previous case, in the esophagus. The authors present a case of diffuse esophageal uptake of Ga-67 in esophageal candidiasis.

  6. The Responsibility Education of Teacher Candidates

    Science.gov (United States)

    Toremen, Fatih

    2011-01-01

    In this study, it was aimed to take the views and suggestions of academicians working at the faculty of education on what can be done about teacher candidates' responsibility education. This study was designed on the basis of qualitative research approach and purposive sampling method was used. Data were collected by unstructured interview method…

  7. Candidal Leukoplakia on Patient with Removable Denture

    Directory of Open Access Journals (Sweden)

    Shiril Paskalis

    2013-07-01

    Full Text Available Candida infection is a common problem in patients using removable dentures, with the most frequent type is denture stomatitis. But other type of candidal infection could also happen in these patients, such as candidal leukoplakia. We reported a 61 years old female patient who complained a painful lesion under her lower removable denture. Oral examination revealed white plaque that could not be rubbed over an ulcer on the lingual part of alveolar processes under the lower removable denture plate, and also an erythematous area on palatum durum above the upper full denture. The patient was suspected to have candidal leukoplakia on the lingual part of the mandible and denture stomatitis on the palate area. The treatment consisted of nystatin oral suspension, chlorhexidine solution, multivitamins, along with denture replacement and oral health education. The entire lesion resolved within 2 months therapy. Candidal infection treatment on denture patient needs not only medication or denture replacement, but also patient compliance to achieve maximal result.

  8. FAME's Search for Extrasolar Planet Candidates

    Science.gov (United States)

    Johnston, K.

    FAME is a five year survey mission to observe the positions, proper motions, and parallaxes of 40,000,000 stars down to 15th magnitude with accuracies of 50 microarcseconds at 9th magnitude. In addition to producing an astrometric and photometric catalog unparalleled for its accuracy and size, the survey will provide significant astrophysics results and search for extrasolar planet candidates.

  9. Secondary Teacher Candidates' Lesson Planning Learning

    Science.gov (United States)

    Santoyo, Christina; Zhang, Shaoan

    2016-01-01

    Teacher candidates (TCs) use clinical experiences to enact concepts taught in their university courses; therefore field experiences may be the most important component of teacher preparation (Hammerness et al., 2005). TCs require support and guidance as they learn to adapt curriculum materials for effective use in the classroom (Davis, 2006). They…

  10. Candidate genes in ocular dominance plasticity

    NARCIS (Netherlands)

    M.L. Rietman; J.-P. Sommeijer; C.N. Levelt; J.A. Heimel; A.B. Brussaard; J.G.G. Borst; Y. Elgersma; N. Galjart; G.T. van der Horst; C.M. Pennartz; A.B. Smit; B.M. Spruijt; M. Verhage; C.I. de Zeeuw

    2012-01-01

    Many studies have been devoted to the identification of genes involved in experience-dependent plasticity in the visual cortex. To discover new candidate genes, we have reexamined data from one such study on ocular dominance (OD) plasticity in recombinant inbred BXD mouse strains. We have correlated

  11. Microlensing Binaries with Candidate Brown Dwarf Companions

    DEFF Research Database (Denmark)

    Shin, I.-G; Han, C.; Gould, A.;

    2012-01-01

    Brown dwarfs are important objects because they may provide a missing link between stars and planets, two populations that have dramatically different formation histories. In this paper, we present the candidate binaries with brown dwarf companions that are found by analyzing binary microlensing ...

  12. Gallium-67 imaging in candidal esophagitis

    International Nuclear Information System (INIS)

    Ga-67 scanning has been used to evaluate esophageal carcinoma. It has demonstrated candidal infection in other body sites and, in one previous case, in the esophagus. The authors present a case of diffuse esophageal uptake of Ga-67 in esophageal candidiasis

  13. Social Justice Perceptions of Teacher Candidates

    Science.gov (United States)

    Turhan, Muhammed

    2010-01-01

    This study aims to determine the social justice perceptions of teacher candidates being trained in an education faculty. For this purpose, national and international literature was reviewed by the researcher and a 32-item questionnaire was developed and implemented on 237 senior year education faculty students. Data from the questionnaires were…

  14. Candidate genes in ocular dominance plasticity

    Directory of Open Access Journals (Sweden)

    M. Liset Rietman

    2012-02-01

    Full Text Available The objective of this study was to identify new candidate genes involved in experience-dependent plasticity. To this aim, we combined previously obtained data from recombinant inbred BXD strains on ocular dominance (OD plasticity and gene expression levels in the neocortex. We validated our approach using a list of genes which alter OD plasticity when inactivated. The expression levels of one fifth of these genes correlated with the amount of OD plasticity. Moreover, the two genes with the highest relative inter-strain differences were among the correlated genes. This suggests that correlation between gene expression levels and OD plasticity is indeed likely to point to genes with a causal role in modulating or generating plasticity in the visual cortex. After this validation on known plasticity genes, we identified new candidate genes by a multi-step approach. First, a list was compiled of all genes of which the expression level in BXD strains correlate with the amount of OD plasticity. To narrow this list to the more promising candidates, we took its cross-section with a list of genes co-regulated with the sensitive period for OD plasticity and a list of genes associated with pathways implicated in OD plasticity. This analysis resulted in a list of 32 candidate genes. The list contained unproven, but not surprising, candidates, such as the genes for IGF-1, NCAM1, NOGO-A, the gamma2 subunit of the GABA(A receptor, acetylcholine esterase and the catalytic subunit of cAMP-dependent protein kinase A. This was indicative of the viability of our approach, but more interesting were the novel candidate genes: Akap7, Akt1, Camk2d, Cckbr, Cd44, Crim1, Ctdsp2, Dnajc5, Gnai1, Itpka, Mapk8, Nbea, Nfatc3, Nlk, Npy5r, Phf21a, Phip, Ppm1l, Ppp1r1b, Rbbp4, Slc1a3, Slit2, Socs2, Spock3, St8sia1, Zfp207. The possible role of some of these candidates is discussed in the article.

  15. Spectral hole-burning and carrier-heating dynamics in quantum-dot amplifiers: Comparison with bulk amplifiers

    DEFF Research Database (Denmark)

    Borri, P.; Langbein, W.; Hvam, Jørn Märcher;

    2001-01-01

    The ultrafast gain dynamics in an electrically pumped InAs/InGaAs/GaAs quantum-dot amplifier are measured at room temperature with femtosecond resolution, and compared with results on an InGaAsP bulk amplifier. The role of spectral hole burning and carrier heating in the recovery of the gain...... compression is investigated. Reduced carrier heating for both gain and refractive index dynamics of the quantum-dot device is found, which is a promising prerequisite for high-speed applications....

  16. Improved tunable microstrip SQUID amplifiers for the Axion Dark Matter eXperiment

    Science.gov (United States)

    O'Kelley, Sean; Hansen, Jørn; Hilton, Gene; Mol, Jan-Michael; Clarke, John; ADMX Collaboration

    2015-04-01

    We describe a series of tunable microstrip SQUID (Superconducting QUantum Interference Device) amplifiers (MSAs) used as the photon detector in the Axion Dark Matter eXperiment (ADMX). Cooled to 100mK or lower, an optimized MSA approaches the quantum limit of detection. The axion dark matter candidate would be detected via Primakoff conversion to a microwave photon in a high-Q (~ 105) tunable microwave cavity, cooled to 1.6 K or lower, in the presence of a 7-tesla magnetic field. The MSA consists of a square loop of thin Nb film, incorporating two resistively shunted Josephson tunnel junctions biased to the voltage state, flux-coupled to a resonant microstrip. The photon frequency is determined by the unknown axion mass, so the cavity and amplifier must be tunable over a broad frequency range. MSA tunability is achieved by terminating the microstrip with a GaAs varactor diode that operates at cryogenic temperatures. This voltage-controlled capacitance enables us to vary the resonant microstrip mode from nearly λ/2 to λ/4. We demonstrate gains exceeding 20 dB, at frequencies above 900 MHz. With proper design of the microwave environment, a noise temperature of 1/2 to 1/4 of the physical temperature is demonstrated. Supported by DOE Grants DE-FG02-97ER41029, DE-FG02-96ER40956, DE- AC52-07NA27344, DE-AC03-76SF00098, NSF Grant 1067242, and the Livermore LDRD program.

  17. The spectacular human nose: an amplifier of individual quality?

    Directory of Open Access Journals (Sweden)

    Åse Kristine Rognmo Mikalsen

    2014-04-01

    Full Text Available Amplifiers are signals that improve the perception of underlying differences in quality. They are cost free and advantageous to high quality individuals, but disadvantageous to low quality individuals, as poor quality is easier perceived because of the amplifier. For an amplifier to evolve, the average fitness benefit to the high quality individuals should be higher than the average cost for the low quality individuals. The human nose is, compared to the nose of most other primates, extraordinary large, fragile and easily broken—especially in male–male interactions. May it have evolved as an amplifier among high quality individuals, allowing easy assessment of individual quality and influencing the perception of attractiveness? We tested the latter by manipulating the position of the nose tip or, as a control, the mouth in facial pictures and had the pictures rated for attractiveness. Our results show that facial attractiveness failed to be influenced by mouth manipulations. Yet, facial attractiveness increased when the nose tip was artificially centered according to other facial features. Conversely, attractiveness decreased when the nose tip was displaced away from its central position. Our results suggest that our evaluation of attractiveness is clearly sensitive to the centering of the nose tip, possibly because it affects our perception of the face’s symmetry and/or averageness. However, whether such centering is related to individual quality remains unclear.

  18. Temporal and transverse coherence of self-amplified spontaneous emission

    Energy Technology Data Exchange (ETDEWEB)

    Kim, K.J.

    1997-06-01

    The authors review the coherence properties of the self-amplified spontaneous emission (SASE). Temporally, SASE is similar to the spontaneous undulator radiation except that the spectral bandwidth is about ten times narrower compared with typical undulator radiation. The situation is quite different in the transverse dimension, where SASE is fully coherent.

  19. Temporal and transverse coherence of self-amplified spontaneous emission

    Energy Technology Data Exchange (ETDEWEB)

    Kim, K. [Lawrence Berkeley National Laboratory, University of California, Berkeley, California94720 (United States)

    1997-06-01

    We review the coherence properties of the self-amplified spontaneous emission (SASE). Temporally, SASE is similar to the spontaneous undulator radiation except that the spectral bandwidth is about ten times narrower compared with typical undulator radiation. The situation is quite different in the transverse dimension, where SASE is fully coherent. {copyright} {ital 1997 American Institute of Physics.}

  20. Semiconductor quantum dot amplifiers for optical signal processing

    DEFF Research Database (Denmark)

    Berg, Tommy Winther; Uskov, A. V.; Bischoff, Svend;

    2001-01-01

    The dynamics of quantum dot semiconductor amplifiers are investigated theoretically with respect to the potential for ultrafast signal processing. The high-speed signal processing capacity of these devices is found to be limited by the wetting layer dynamics in case of electrical pumping, while...... optical pumping partly removes this limitation. Also, the possibility of using spectral hole burning for signal processing is discussed....

  1. Giant Geometrically Amplified Piezoresistance in Metal-Semiconductor Hybrid Resistors

    DEFF Research Database (Denmark)

    Hansen, Ole; Reck, Kasper; Thomsen, Erik Vilain

    2008-01-01

    We show that very high geometrically amplified piezoresistance can indeed be obtained in microstructured metal-semiconductor hybrid devices, even significantly higher amplification factors than the factor of approximately 8 demonstrated recently by Rowe and co-workers may be achieved. However, we...

  2. The Pathological and Physiological Roles of IL-6 Amplifier Activation

    Directory of Open Access Journals (Sweden)

    Masaaki Murakami, Toshio Hirano

    2012-01-01

    Full Text Available The NFκB-triggered positive feedback loop for IL-6 signaling in type 1 collagen+ non-immune cells (IL-6 amplifier was first discovered to be a synergistic signal that is activated following IL-17A and IL-6 stimulation in type 1 collagen+ non-immune cells. Subsequent disease models have shown that it can also be stimulated by the simultaneous activation of NFκB and STAT3, functions as a local chemokine inducer, and acts as a mechanism for local inflammation, particularly chronic ones like rheumatoid arthritis and a multiple sclerosis. Moreover, we have recently shown that hyper activation of the IL-6 amplifier via regional neural activation establishes a gateway for immune cells including autoreactive T cells to pass the blood-brain barrier at dorsal vessels in 5th lumbar cord. Here we review how the IL-6 amplifier is activated by neural activation and the physiological relevance of the gateway to the central nervous system. Accumulating evidences continues to suggest that the IL-6 amplifier offers a potential molecular mechanism for the relationship between neural activation and the development of inflammatory diseases, which could establish a new interdisciplinary field that fuses neurology and immunology.

  3. A European Project on Vacuum Tube Amplifiers for THz Amplification

    DEFF Research Database (Denmark)

    Paoloni, Claudio; Di Carlo, Aldo; Brunetti, Francesca;

    2012-01-01

    The OPTHER (Optically Driven THz amplifier) project supported by the European Commission within the Seventh Framework Program (FP7) represents the first joint European attempt to realize vacuum electron devices in THz range. The target of the project was to design and realize the first 1 THz vacuum...

  4. Transistor biased amplifier minimizes diode discriminator threshold attenuation

    Science.gov (United States)

    Larsen, R. N.

    1967-01-01

    Transistor biased amplifier has a biased diode discriminator driven by a high impedance /several megohms/ current source, rather than a voltage source with several hundred ohms output impedance. This high impedance input arrangement makes the incremental impedance of the threshold diode negligible relative to the input impedance.

  5. The Gain Dependence of the Power Transient in Raman Amplifier

    Institute of Scientific and Technical Information of China (English)

    Zheng Lei; Zhang Jiahong; Chen Zhangyuan; Wu Deming; Xu Anshi

    2003-01-01

    It is observed that the amplitude of the power transient overshoot depends on the gain of the amplifier when the input signal powers are the same. The other system parameters, such as the input pump power and fiber length, have no effects on it.

  6. Optimizing bandwidth and dynamic range of lumped Josephson parametric amplifiers

    Science.gov (United States)

    Eddins, A.; Vijay, R.; Macklin, C.; Minev, Z.; Siddiqi, I.

    2013-03-01

    Superconducting parametric amplifiers have revolutionized the field of quantum measurement by providing high gain, ultra-low noise amplification. They have been used successfully for high-fidelity qubit state measurements, probing nano-mechanical resonators, quantum feedback, and for microwave quantum optics experiments. Though several designs exist, a simple and robust architecture is the Lumped Josephson Parametric Amplifier (LJPA). This device consists of a capacitively shunted SQUID directly coupled to a transmission line to form a low quality factor (Q) nonlinear resonator. We discuss amplifiers which can be tuned over the full 4-8 GHz band with 20-25 dB of gain and 10 - 50 MHz of signal bandwidth. However, similar to other parametric amplifiers employing a resonant circuit, the LJPA suffers from low dynamic range and has a -1 dB gain compression point of order -130 dBm. We explore new designs comprised of an array of SQUIDs to improve the dynamic range. We will present the results of numerical simulations and preliminary experiments. We will also briefly discuss improvements obtained from different biasing methods and packaging. This research was supported by the Army Research Office under a QCT grant.

  7. Amplified spontaneous emission pulses for high-power supercontinuum generation

    Directory of Open Access Journals (Sweden)

    Huan Huan Liu

    2016-03-01

    Full Text Available The authors demonstrate an incoherent light source based on a reflective semiconductor optical amplifier as pump for high-power supercontinuum generation for the first time. The obtained power level is about 160 mW and 20 dB spectral bandwidth is around 170 nm.

  8. Theory of the singly quasidegenerate Josephson junction parametric amplifier

    DEFF Research Database (Denmark)

    Sørensen, O.H.; Dueholm, B.; Mygind, Jesper;

    1980-01-01

    A comprehensive account of the theory of the singly quasidegenerate Josephson junction parametric amplifier is given. In this mode the signal and idler frequencies are both approximately equal to half the pump frequency, and hence the signal and idler channels have a common termination. It is shown...

  9. Sexing birds using random amplified polymorphic DNA (RAPD) markers

    NARCIS (Netherlands)

    Lessells, C.M.; Mateman, A.C.

    1998-01-01

    We used random amplified polymorphic DNA (RAPD) markers to sex birds from small tissue (usually blood) samples. Arbitrarily chosen 10-mer PCR primers were screened with DNA from known-sex individuals for the production of a bright female-specific band. Suitable primers were found for seven bird spec

  10. Field Effect Transistor /FET/ circuit for variable gin amplifiers

    Science.gov (United States)

    Spaid, G. H.

    1969-01-01

    Amplifier circuit using two FETs combines improved input and output impedances with relatively large signal handling capability and an immunity from adverse effects of automatic gain control. Circuit has sources and drains in parallel plus a resistive divider for signal and bias to either of the gate terminals.

  11. Multi Carrier Modulator for Switch-Mode Audio Power Amplifiers

    DEFF Research Database (Denmark)

    Knott, Arnold; Pfaffinger, Gerhard; Andersen, Michael Andreas E.

    2008-01-01

    -mode audio power amplifiers while keeping the performance measures to excellent levels is therefore of high general interest. A modulator utilizing multiple carrier signals to generate a two level pulse train will be shown in this paper. The performance of the modulator will be compared in simulation...

  12. Population structure of Salmonella investigated by amplified fragment length polymorphism

    DEFF Research Database (Denmark)

    Torpdahl, M.; Ahrens, Peter

    2004-01-01

    Aims: This study was undertaken to investigate the usefulness of amplified fragment length polymorphism (AFLP) in determining the population structure of Salmonella. Methods and Results: A total of 89 strains were subjected to AFLP analysis using the enzymes BglII and BspDI, a combination...

  13. 2R Regeneration in Concatenated Semiconductor Optical Amplifiers and Electroabsorbers

    DEFF Research Database (Denmark)

    Christiansen, Lotte Jin; Xu, Lin; Yvind, Kresten;

    2004-01-01

    We present a novel 2R regenerator with a large level separation and steep step a sharp, adjustable threshold based on concatenated semiconductor optical amplifiers and electroabsorbers. We demonstrate demonstrate improvements in both extinction-ratio and BER sensitivity atfor a 10 Gb/s NRZ signal....

  14. Current-Driven Switch-Mode Audio Power Amplifiers

    DEFF Research Database (Denmark)

    Knott, Arnold; Buhl, Niels Christian; Andersen, Michael A. E.

    2012-01-01

    The conversion of electrical energy into sound waves by electromechanical transducers is proportional to the current through the coil of the transducer. However virtually all audio power amplifiers provide a controlled voltage through the interface to the transducer. This paper is presenting a sw...

  15. A fully integrated 16 channel digitally trimmed pulse shaping amplifier

    International Nuclear Information System (INIS)

    A fully integrated CMOS pulse shaping amplifier has been developed at LBL. All frequency dependent networks are included on the chip. Provision is made for tuning to compensate for process variations. The overall architecture and details of the circuitry are discussed. Test results are presented

  16. K-Band Traveling-Wave Tube Amplifier

    Science.gov (United States)

    Force, Dale A.; Simons, Rainee N.; Peterson, Todd T.; Spitsen, Paul C.

    2010-01-01

    A new space-qualified, high-power, high-efficiency, K-band traveling-wave tube amplifier (TWTA) will provide high-rate, high-capacity, direct-to-Earth communications for science data and video gathered by the Lunar Reconnaissance Orbiter (LRO) during its mission. Several technological advances were responsible for the successful demonstration of the K-band TWTA.

  17. Noise Shaping Filter Compensating PWM Distortion for Fully Digital Amplifier

    Science.gov (United States)

    Yoneya, Akihiko

    The full-digital audio amplifiers have several merits such as a high power enabling a small size of the amplifier and digital implementation of the signal processing which allows desired precision of the processing except for the final stage switching amplifiers. Unfortunately, the pulse width modulation (PWM) causes signal distortions because of the non-linearity of the modulation from the viewpoint of the transient response. This paper proposes a compensation method of the PWM distortion with feedback approach. In the noise-shaping filter of the delta-sigma modulator to calculate the pulse codes for the PWM, the distortion caused by the PWM is evaluated and fed it back to compensate the distortion. Eventually the filter is implemented as a state-variable filter with non-linear feedback from the quantizer. The calculation of the filter elements is also described. By using proposed filters, PWM signals with small distortions and small floor noise can be obtained to realize high-fidelity audio amplifiers.

  18. Quantum dot amplifiers with high output power and low noise

    DEFF Research Database (Denmark)

    Berg, Tommy Winther; Mørk, Jesper

    2003-01-01

    Quantum dot semiconductor optical amplifiers have been theoretically investigated and are predicted to achieve high saturated output power, large gain, and low noise figure. We discuss the device dynamics and, in particular, show that the presence of highly inverted barrier states does not limit...

  19. Can El Nino Amplify the Solar Forcing of Climate?

    Science.gov (United States)

    Ruzmaikin, A.

    1999-01-01

    ENSO (El Nino and the Southern Oscillation) is considered as a stochastic driver that excites the atmospheric anomaly states, such as Pacific North American pattern. This can make the 11 year solar activity forcing feasible to climate through stochastic resonance -- a phenomenon that amplifies a weak input to a nonlinear bistable system by the assistance of noise.

  20. Development and energization of IOT based RF amplifier

    International Nuclear Information System (INIS)

    A 704 MHz IOT based CW RF amplifier has been developed in VECC. It can also be used with proper tuning to power cavity modules operating at 650 MHz in high energy high intensity proton linear accelerator proposed to be built for ADSS/SNS programme in India and Project-X at Fermilab, USA. This IOT based amplifier provides up to 60 kW continuous wave RF power at 700 MHz. It required various power supplies, LCW cooling and forced air cooling for its operation. The auxiliary power supplies like Grid, Filament and Ion-pump, are floated and mounted on an isolated frame, i.e., HV deck. The mains inputs are electrically isolated by means of isolation transformer. Also, a Programmable Logic Controller (PLC) based interlocks along with high voltage collector power supply has been designed and developed for the safe operation of the RF amplifier. This paper discusses about various developments and energization of the IOT based RF amplifier with high power dummy load. (author)