WorldWideScience

Sample records for cancer tangle toggle

  1. 2-Tangles

    CERN Document Server

    Baez, J C; Baez, John C.; Langford, Laurel

    1997-01-01

    Just as links may be algebraically described as certain morphisms in the category of tangles, compact surfaces smoothly embedded in R^4 may be described as certain 2-morphisms in the 2-category of `2-tangles in 4 dimensions'. In this announcement we give a purely algebraic characterization of the 2-category of unframed unoriented 2-tangles in 4 dimensions as the `free semistrict braided monoidal 2-category with duals on one unframed self-dual object'. A forthcoming paper will contain a proof of this result using the movie moves of Carter, Rieger and Saito. We comment on how one might use this result to construct invariants of 2-tangles.

  2. Drying leather with vacuum and toggling sequentially

    Science.gov (United States)

    We investigated a drying method that will enable leather to be dried under vacuum and stretch sequentially to improve area yield. Vacuum drying offers fast speed at a low temperature, which would be advantageous to heat-vulnerable chrome-free leather. Adding a toggle action after vacuum drying cou...

  3. Ultrafast nanomagnetic toggle switching of vortex cores

    OpenAIRE

    Hertel, R.; Gliga, S.; Fähnle, M.; Schneider, C. M.

    2007-01-01

    We present an ultrafast route for a controlled, toggle switching of magnetic vortex cores with ultrashort unipolar magnetic field pulses. The switching process is found to be largely insensitive to extrinsic parameters, like sample size and shape, and it is faster than any field-driven magnetization reversal process previously known from micromagnetic theory. Micromagnetic simulations demonstrate that the vortex core reversal is mediated by a rapid sequence of vortex-antivortex pair creation ...

  4. The Last Tangle of Tau

    OpenAIRE

    Ding, Huiping; Johnson, Gail V. W.

    2008-01-01

    Tau aggregates into neurofibrillary tangles in Alzheimer’s disease and tauopathies. There is ongoing debate about whether tau aggregation is toxic and which form of tau is toxic. Based on recent studies showing that mature tau tangles can be dissociated from neuronal loss and cognitive deficits, it can be hypothesized that the intermediate pre-fibrillar tau aggregate is the predominant neurotoxic tau species. The toxicity of tau aggregation includes loss of physiological functions of native t...

  5. TOGGLE: toolbox for generic NGS analyses

    OpenAIRE

    Monat, Cécile; Tranchant-Dubreuil, Christine; Kougbeadjo, Ayité; Farcy , Cédric; Ortega-Abboud, Enrique; Amanzougarene, Souhila; Ravel, Sébastien; Agbessi, Mawusse; Orjuela-Bouniol, Julie; Summo, Marilyne; Sabot, François

    2015-01-01

    Background: The explosion of NGS (Next Generation Sequencing) sequence data requires a huge effort in Bioinformatics methods and analyses. The creation of dedicated, robust and reliable pipelines able to handle dozens of samples from raw FASTQ data to relevant biological data is a time-consuming task in all projects relying on NGS. To address this, we created a generic and modular toolbox for developing such pipelines. Results: TOGGLE (TOolbox for Generic nGs anaLysEs) is a suite of tools abl...

  6. TOGGLE: toolbox for generic NGS analyses

    OpenAIRE

    Monat, Cécile; Tranchant-Dubreuil, Christine; Kougbeadjo, Ayité; Farcy, Cédric; Ortega-Abboud, Enrique; Amanzougarene, Souhila; Ravel, Sébastien; Agbessi, Mawusse; Orjuela-Bouniol , Julie; Summo, Marilyne; Sabot, François

    2015-01-01

    Background The explosion of NGS (Next Generation Sequencing) sequence data requires a huge effort in Bioinformatics methods and analyses. The creation of dedicated, robust and reliable pipelines able to handle dozens of samples from raw FASTQ data to relevant biological data is a time-consuming task in all projects relying on NGS. To address this, we created a generic and modular toolbox for developing such pipelines. Results TOGGLE (TOolbox for Generic nGs anaLysEs) is a suite of tools able ...

  7. Coarsening mechanics of a colloidal suspension in toggled fields

    Science.gov (United States)

    Bauer, Jonathan L.; Liu, Yifei; Kurian, Martin J.; Swan, James W.; Furst, Eric M.

    2015-08-01

    Suspensions of paramagnetic colloids are driven to phase separate and self-assemble in toggled magnetic fields. At field strengths above 575 A/m and toggle frequencies between 0.66 and 2 Hz, an initial gel-like, arrested network collapses into condensed, ellipsoidal aggregates. The evolution to this equilibrium structure occurs via a Rayleigh-Plateau instability. The toggle frequency ν determines the fluidity of the breakup process. At frequencies between 0.66 and 1.5 Hz, the suspension breaks up similar to a viscous, Newtonian fluid. At frequencies ν > 1.5 Hz, the network ruptures like a viscoplastic material. The field strength alters the onset time of the instability. A power law relationship emerges as the scaled frequency and field strength can be used to predict the onset of breakup. These results further aid in understanding the mechanics and dynamics of the phase separation process of suspensions of polarizable colloids in toggled external fields.

  8. Use of Computer Vision to Detect Tangles in Tangled Objects

    OpenAIRE

    Parmar, Paritosh

    2014-01-01

    Untangling of structures like ropes and wires by autonomous robots can be useful in areas such as personal robotics, industries and electrical wiring & repairing by robots. This problem can be tackled by using computer vision system in robot. This paper proposes a computer vision based method for analyzing visual data acquired from camera for perceiving the overlap of wires, ropes, hoses i.e. detecting tangles. Information obtained after processing image according to the proposed method compr...

  9. The Toggle Local Planner for sampling-based motion planning

    KAUST Repository

    Denny, Jory

    2012-05-01

    Sampling-based solutions to the motion planning problem, such as the probabilistic roadmap method (PRM), have become commonplace in robotics applications. These solutions are the norm as the dimensionality of the planning space grows, i.e., d > 5. An important primitive of these methods is the local planner, which is used for validation of simple paths between two configurations. The most common is the straight-line local planner which interpolates along the straight line between the two configurations. In this paper, we introduce a new local planner, Toggle Local Planner (Toggle LP), which extends local planning to a two-dimensional subspace of the overall planning space. If no path exists between the two configurations in the subspace, then Toggle LP is guaranteed to correctly return false. Intuitively, more connections could be found by Toggle LP than by the straight-line planner, resulting in better connected roadmaps. As shown in our results, this is the case, and additionally, the extra cost, in terms of time or storage, for Toggle LP is minimal. Additionally, our experimental analysis of the planner shows the benefit for a wide array of robots, with DOF as high as 70. © 2012 IEEE.

  10. Seidel-Smith cohomology for tangles

    DEFF Research Database (Denmark)

    Rezazadegan, Reza

    2009-01-01

    We generalize the “symplectic Khovanov cohomology” of Seidel and Smith (Duke Math J 134(3):453–514, 2006) to tangles using the notion of symplectic valued topological field theory introduced by Wehrheim and Woodward (arXiv:0905.1368).......We generalize the “symplectic Khovanov cohomology” of Seidel and Smith (Duke Math J 134(3):453–514, 2006) to tangles using the notion of symplectic valued topological field theory introduced by Wehrheim and Woodward (arXiv:0905.1368)....

  11. Oh What a Tangled Biofilm Web Bacteria Weave

    Science.gov (United States)

    ... Inside Life Science > Oh What a Tangled Biofilm Web Bacteria Weave Inside Life Science View All Articles | Inside Life Science Home Page Oh What a Tangled Biofilm Web Bacteria Weave By Elia Ben-Ari Posted May ...

  12. Vortex knots in tangled quantum eigenfunctions

    Science.gov (United States)

    Taylor, Alexander J.; Dennis, Mark R.

    2016-07-01

    Tangles of string typically become knotted, from macroscopic twine down to long-chain macromolecules such as DNA. Here, we demonstrate that knotting also occurs in quantum wavefunctions, where the tangled filaments are vortices (nodal lines/phase singularities). The probability that a vortex loop is knotted is found to increase with its length, and a wide gamut of knots from standard tabulations occur. The results follow from computer simulations of random superpositions of degenerate eigenstates of three simple quantum systems: a cube with periodic boundaries, the isotropic three-dimensional harmonic oscillator and the 3-sphere. In the latter two cases, vortex knots occur frequently, even in random eigenfunctions at relatively low energy, and are constrained by the spatial symmetries of the modes. The results suggest that knotted vortex structures are generic in complex three-dimensional wave systems, establishing a topological commonality between wave chaos, polymers and turbulent Bose-Einstein condensates.

  13. Vortex knots in tangled quantum eigenfunctions

    CERN Document Server

    Taylor, Alexander J

    2016-01-01

    Tangles of string typically become knotted, from macroscopic twine down to long-chain macromolecules such as DNA. Here we demonstrate that knotting also occurs in quantum wavefunctions, where the tangled filaments are vortices (nodal lines/phase singularities). The probability that a vortex loop is knotted is found to increase with its length, and a wide gamut of knots from standard tabulations occur. The results follow from computer simulations of random superpositions of degenerate eigenstates of three simple quantum systems: a cube with periodic boundaries, the isotropic 3-dimensional harmonic oscillator and the 3-sphere. In the latter two cases, vortex knots occur frequently, even in random eigenfunctions at relatively low energy, and are constrained by the spatial symmetries of the modes. The results suggest that knotted vortex structures are generic in complex 3-dimensional wave systems, establishing a topological commonality between wave chaos, polymers and turbulent Bose-Einstein condensates.

  14. Synthesising gene clock with toggle switch and oscillator.

    Science.gov (United States)

    Lin, Chun-Liang; Chen, Po-Kuei; Cheng, Young-Yi

    2015-06-01

    The usefulness of a genetic clock lies in its role to stimulate a sequence of logic reactions for sequential biological circuits. A clock signal is a periodic square wave, its amplitude alternates at a steady frequency between fixed minimal and maximal levels. Transition between the minimum and the maximum is instantaneous for an ideal square wave; however, the function is unrealisable in physical bio-systems. This research develops a new genetic clock generator based on a genetic oscillator, in which, a sine wave generator is adopted as a signal oscillator. It is shown that combination of a genetic oscillator with a toggle switch is able to generate clock signals forming an efficient way to generate a near square wave. In silico study confirms the proposed idea.

  15. Mutual information in the Tangled Nature Model

    DEFF Research Database (Denmark)

    Jones, Dominic; Jeldtoft Jensen, Henrik; Sibani, Paolo

    2009-01-01

    We consider the concept of mutual information in ecological networks, and use this idea to analyse the Tangled Nature model of co-evolution. We show that this measure of correlation has two distinct behaviours depending on how we define the network in question: if we consider only the network...... of viable species this measure increases, whereas for the whole system it decreases. It is suggested that these are complimentary behaviours that show how ecosystems can become both more stable and better adapted....

  16. Toggle PRM: A Coordinated Mapping of C-Free and C-Obstacle in Arbitrary Dimension

    KAUST Repository

    Denny, Jory

    2013-01-01

    Motion planning has received much attention over the past 40 years. More than 15 years have passed since the introduction of the successful sampling-based approach known as the Probabilistic RoadMap Method (PRM). PRM and its many variants have demonstrated great success for some high-dimensional problems, but they all have some level of difficulty in the presence of narrow passages. Recently, an approach called Toggle PRM has been introduced whose performance does not degrade for 2-dimensional problems with narrow passages. In Toggle PRM, a simultaneous, coordinated mapping of both C free and C obst is performed and every connection attempt augments one of the maps – either validating an edge in the current space or adding a configuration ’witnessing’ the connection failure to the other space. In this paper, we generalize Toggle PRM to d-dimensions and show that the benefits of mapping both C free and C obst continue to hold in higher dimensions. In particular, we introduce a new narrow passage characterization, α-ε-separable narrow passages, which describes the types of passages that can be successfully mapped by Toggle PRM. Intuitively, α-ε-separable narrow passages are arbitrarily narrow regions of C free that separate regions of C obst , at least locally, such as hallways in an office building. We experimentally compare Toggle PRM with other methods in a variety of scenarios with different types of narrow passages and robots with up to 16 dof.

  17. Lazy Toggle PRM: A single-query approach to motion planning

    KAUST Repository

    Denny, Jory

    2013-05-01

    Probabilistic RoadMaps (PRMs) are quite suc-cessful in solving complex and high-dimensional motion plan-ning problems. While particularly suited for multiple-query scenarios and expansive spaces, they lack efficiency in both solving single-query scenarios and mapping narrow spaces. Two PRM variants separately tackle these gaps. Lazy PRM reduces the computational cost of roadmap construction for single-query scenarios by delaying roadmap validation until query time. Toggle PRM is well suited for mapping narrow spaces by mapping both Cfree and Cobst, which gives certain theoretical benefits. However, fully validating the two resulting roadmaps can be costly. We present a strategy, Lazy Toggle PRM, for integrating these two approaches into a method which is both suited for narrow passages and efficient single-query calculations. This simultaneously addresses two challenges of PRMs. Like Lazy PRM, Lazy Toggle PRM delays validation of roadmaps until query time, but if no path is found, the algorithm augments the roadmap using the Toggle PRM methodology. We demonstrate the effectiveness of Lazy Toggle PRM in a wide range of scenarios, including those with narrow passages and high descriptive complexity (e.g., those described by many triangles), concluding that it is more effective than existing methods in solving difficult queries. © 2013 IEEE.

  18. Whitney categories and the Tangle Hypothesis

    CERN Document Server

    Smyth, Conor

    2011-01-01

    We propose a new notion of `n-category with duals', which we call a Whitney n-category. There are two motivations. The first is that Baez and Dolan's Tangle Hypothesis is (almost) tautological when interpreted as a statement about Whitney categories. The second is that we can functorially construct `fundamental Whitney n-categories' from each smooth stratified space X. These are obtained by considering the homotopy theory of smooth maps into X which are transversal to all strata. This makes concrete another idea of Baez and Dolan's which is that a suitable version of homotopy theory for stratified spaces should allow one to generalise the relationship between spaces and groupoids to one between stratified spaces and categories with duals.

  19. Torsional Oscillations of a Magnetar with a Tangled Magnetic Field

    Science.gov (United States)

    Link, Bennett; van Eysden, C. Anthony

    2016-05-01

    Motivated by stability considerations and observational evidence, we argue that magnetars possess highly tangled internal magnetic fields. We propose that the quasi-periodic oscillations (QPOs) seen to accompany giant flares can be explained as torsional modes supported by a tangled magnetic field, and we present a simple model that supports this hypothesis for SGR 1900+14. Taking the strength of the tangle as a free parameter, we find that the magnetic energy in the tangle must dominate that in the dipolar component by a factor of ˜14 to accommodate the observed 28 Hz QPO. Our simple model provides useful scaling relations for how the QPO spectrum depends on the bulk properties of the neutron star and the tangle strength. The energy density in the tangled field inferred for SGR 1900+14 renders the crust nearly dynamically irrelevant, a significant simplification for study of the QPO problem. The predicted spectrum is about three times denser than observed, which could be explained by preferential mode excitation or beamed emission. We emphasize that field tangling is needed to stabilize the magnetic field, so should not be ignored in treatment of the QPO problem. Supplementary material for this article has been published in Link & van Eysden (2016).

  20. Tangling of Tethered Swimmers: Interactions between Two Nematodes

    Science.gov (United States)

    Backholm, Matilda; Schulman, Rafael D.; Ryu, William S.; Dalnoki-Veress, Kari

    2014-09-01

    The tangling of two tethered microswimming worms serving as the ends of "active strings" is investigated experimentally and modeled analytically. C. elegans nematodes of similar size are caught by their tails using micropipettes and left to swim and interact at different separations over long times. The worms are found to tangle in a reproducible and statistically predictable manner, which is modeled based on the relative motion of the worm heads. Our results provide insight into the intricate tangling interactions present in active biological systems.

  1. Lipids: Part of the tangled web

    Energy Technology Data Exchange (ETDEWEB)

    Krauss, R.M.

    1992-08-01

    Analysis of LDL subclasses by non-denaturing gradient gel electrophoresis has led to the identification of a subclass pattern characterized by predominance of small LDL, designated LDL subclass pattern B. The prevalence of pattern B in the general population is approximately 25%, but varies as a function of age and gender, being relatively uncommon in children and in premenopausal women. The remainder of the population has a predominance of larger LDL (pattern A) or an intermediate pattern. Our findings indicate that LDL subclass pattern B is an integral part of the ``tangled web`` of interrelated coronary disease risk factors associated with insulin resistance. It may be that the pathologic features of this lipoprotein profile, including the relative atherogenicity of small, dense LDL and IDL, contribute importantly to the increased risk of cardiovascular disease in subjects with insulin resistance and hypertension. Furthermore, pattern B serves as a marker for a common genetic trait which may underlie a substantial portion of the familial predisposition to coronary artery disease in the general population. Studies of hormonal, dietary, and pharmacologic influences on expression of this atherogenic phenotype should lead to more effective identification and management of high-risk individuals, and improved approaches to disease prevention in high-risk families.

  2. Lipids: Part of the tangled web

    Energy Technology Data Exchange (ETDEWEB)

    Krauss, R.M.

    1992-08-01

    Analysis of LDL subclasses by non-denaturing gradient gel electrophoresis has led to the identification of a subclass pattern characterized by predominance of small LDL, designated LDL subclass pattern B. The prevalence of pattern B in the general population is approximately 25%, but varies as a function of age and gender, being relatively uncommon in children and in premenopausal women. The remainder of the population has a predominance of larger LDL (pattern A) or an intermediate pattern. Our findings indicate that LDL subclass pattern B is an integral part of the tangled web'' of interrelated coronary disease risk factors associated with insulin resistance. It may be that the pathologic features of this lipoprotein profile, including the relative atherogenicity of small, dense LDL and IDL, contribute importantly to the increased risk of cardiovascular disease in subjects with insulin resistance and hypertension. Furthermore, pattern B serves as a marker for a common genetic trait which may underlie a substantial portion of the familial predisposition to coronary artery disease in the general population. Studies of hormonal, dietary, and pharmacologic influences on expression of this atherogenic phenotype should lead to more effective identification and management of high-risk individuals, and improved approaches to disease prevention in high-risk families.

  3. Torsional Oscillations of a Magnetar with a Tangled Magnetic Field

    CERN Document Server

    Link, Bennett

    2016-01-01

    Motivated by stability considerations and observational evidence, we argue that magnetars possess highly-tangled internal magnetic fields. We propose that the quasi-periodic oscillations (QPOs) seen to accompany giant flares can be explained as torsional modes supported by a tangled magnetic field, and we present a simple model that supports this hypothesis for SGR 1900+14. Taking the strength of the tangle as a free parameter, we find that the magnetic energy in the tangle must dominate that in the dipolar component by a factor of $\\sim 14$ to accommodate the observed 28 Hz QPO. Our simple model provides useful scaling relations for how the QPO spectrum depends on the bulk properties of the neutron star and the tangle strength. The energy density in the tangled field inferred for SGR 1900+14 renders the crust nearly dynamically irrelevant, a significant simplification for study of the QPO problem. The predicted spectrum is about three times denser than observed, which could be explained by preferential mode ...

  4. Drying Chrome-free Leather Using a Combination of Vacuum and Toggling

    Science.gov (United States)

    Drying, by which leather acquires its final texture, consistency and flexibility, is one of the most important operations in leather manufacturing. The objective for this research is to obtain an improved drying method, merging toggling and vacuum drying together. This is because vacuum drying offe...

  5. On the universal sl_2 invariant of Brunnian bottom tangles

    CERN Document Server

    Suzuki, Sakie

    2011-01-01

    A link L is called Brunnian if every proper sublink of L is trivial. Similarly, a bottom tangle T is called Brunnian if every proper subtangle of T is trivial. In this paper, we give a small subalgebra of the n-fold completed tensor power of U_h(sl_2) in which the universal sl_2 invariant of n-component Brunnian bottom tangles takes values. As an application, we give a divisibility property of the colored Jones polynomial of Brunnian links.

  6. On the universal sl_2 invariant of boundary bottom tangles

    CERN Document Server

    Suzuki, Sakie

    2011-01-01

    The universal sl_2 invariant of bottom tangles has a universality property for the colored Jones polynomial of links. Habiro conjectured that the universal sl_2 invariant of boundary bottom tangles takes values in certain subalgebras of the completed tensor powers of the quantized enveloping algebra U_h(sl_2) of the Lie algebra sl_2. In the present paper, we prove an improved version of Habiro's conjecture. As an application, we prove a divisibility property of the colored Jones polynomial of boundary links.

  7. An Obstruction to Embedding 4-Tangles in Links

    OpenAIRE

    Krebes, David A.

    1999-01-01

    We consider the ways in which a 4-tangle T inside a unit cube can be extended outside the cube into a knot or link L. We present two links n(T) and d(T) such that the greatest common divisor of the determinants of these two links always divides the determinant of the link L. In order to prove this result we give a two-integer invariant of 4-tangles. Calculations are facilitated by viewing the determinant as the Kauffman bracket at a fourth root of -1, which sets the loop factor to zero. For r...

  8. Toggled RNA Aptamers Against Aminoglycosides Allowing Facile Detection of Antibiotics Using Gold Nanoparticle Assays

    OpenAIRE

    Derbyshire, Nicola; White, Simon J.; Bunka, David H. J.; Song, Lei; Stead, Sara; Tarbin, Jonathan; Sharman, Matthew; Zhou, Dejian; Stockley, Peter G.

    2012-01-01

    We have used systematic evolution of ligands by exponential enrichment (SELEX) to isolate RNA aptamers against aminoglycoside antibiotics. The SELEX rounds were toggled against four pairs of aminoglycosides with the goal of isolating reagents that recognize conserved structural features. The resulting aptamers bind both of their selection targets with nanomolar affinities. They also bind the less structurally related targets, although they show clear specificity for this class of antibiotics....

  9. Nanomagnetic toggle switching of vortex cores on the picosecond time scale

    OpenAIRE

    Hertel, R.; Gliga, S.; Fähnle, M.; Schneider, C. M.

    2006-01-01

    We present an ultrafast route for a controlled, toggle switching of magnetic vortex cores with ultrashort unipolar magnetic field pulses. The switching process is found to be largely insensitive to extrinsic parameters, like sample size and shape, and it is faster than any field-driven magnetization reversal process previously known from micromagnetic theory. Micromagnetic simulations demonstrate that the vortex core reversal is mediated by a rapid sequence of vortex-antivortex pair-creation ...

  10. A lattice gas model on a tangled chain

    International Nuclear Information System (INIS)

    We have used a model of a lattice gas defined on a tangled chain to study the enzyme kinetics by a modified transfer matrix method. By using a simple iterative algorithm we have obtained different kinds of saturation curves for different configurations of the tangled chain and different types of the additional interactions. In some special cases of configurations and interactions we have found the same equations for the saturation curves, which we have obtained before studying the lattice gas model with nearest neighbor interactions or the lattice gas model with alternate nearest neighbor interactions, using different techniques as the correlated walks' theory, the partition point technique or the transfer matrix model. This more general model and the new results could be useful for the experimental investigations. (author). 20 refs, 6 figs

  11. The Tangled Nature Model of evolutionary dynamics reconsidered

    DEFF Research Database (Denmark)

    Andersen, Christian Walther; Sibani, Paolo

    2016-01-01

    The Tangled Nature Model of biological and cultural evolution features interacting agents which compete for limited resources and reproduce in an error prone fashion and at a rate depending on the `tangle' of interactions they maintain with others. The set of interactions linking a TNM individual...... all the interactions, while increasing $K$ up to the length of the genome ensures an increasing level of trait inheritance. We show that the distribution of the interactions generated by our rule is nearly independent of the value of $K$. Changing $K$ strengthens the core structure of the ecology....../t_{\\rm w}$, similarity to the pure aging behaviour approximately describing glassy systems of physical origin. Increasing the value of $K$ decreases the numerical value of the decay exponent of the power law, which is a clear quantitative dynamical effect of trait inheritance....

  12. Torsional oscillations of neutron stars with highly tangled magnetic fields

    CERN Document Server

    Sotani, Hajime

    2015-01-01

    To determine the frequencies of magnetic oscillations in the neutron stars with highly tangled magnetic fields, we derive the perturbation equations. We assume that the field strength of the global magnetic structure is so small that such fields are negligible compared with the tangled fields, which may still be far from a realistic configuration. Then, we systematically examine the spectra of the magnetic oscillations, as varying the magnetic field strength and stellar mass. The frequencies without crust elasticity are completely proportional to the strength of magnetic field, whose proportionality constant depends strongly on the stellar mass. On the other hand, the oscillation spectra with crust elasticity become more complicated, where the frequencies even for weak magnetic fields are different from the crustal torsional oscillations without magnetic fields. For discussing the spectra, the critical field strength can play an important role, which is determined in such a way that the shear velocity is equi...

  13. Evaluation report for toggle switches: Texas Instruments, Inc., Apollo-type, and Daven Measurements part number 45000-XXX, job order 32-139

    Science.gov (United States)

    Labberton, D.

    1974-01-01

    A preliminary evaluation of environmental capabilities was undertaken on toggle switches and on Apollo-type toggle switches. The purpose of this evaluation was to take a first look at their tested capabilities for the purpose of determining whether the candidate hardware appears to have a good chance of successfully completing a detailed envrionmental qualification test program.

  14. Torsional oscillations of a magnetar with a tangled magnetic field

    CERN Document Server

    Link, Bennett

    2015-01-01

    We propose a scenario for the quasi-periodic oscillations observed in magnetar flares wherein a tangled component of the stellar magnetic field introduces nearly isotropic stress that gives the fluid core of the star an effective shear modulus. In a simple, illustrative model of constant density, the tangled field eliminates the problematic Alfv\\'en continuum that would exist in the stellar core for an organized field. For a tangled field energy density comparable to that inferred from the measured dipole fields of $\\sim 10^{15}$ G in SGRs 1806-20 and 1900+14, torsional modes exist with fundamental frequencies of about 20 Hz, and mode spacings of $\\sim 10$ Hz. For fixed stellar mass and radius, the model has only one free parameter, and can account for {\\em every} observed QPO under 160 Hz to within 3 Hz for both SGRs 1806-20 and 1900+14. The combined effects of stratification and crust stresses generally decrease the frequencies of torsional oscillations by $<10$% for overtones and increase the lowest-fre...

  15. Homoclinic tangle of the separatrix of the Symmetric Quartic Map

    Science.gov (United States)

    Settle, Talise; Jones, Bilal; Baldwin, Danielle; Ali, Halima; Punjabi, Alkesh

    2015-11-01

    The equilibrium separatrix of the Symmetric Quartic Map (SQM) is calculated in natural canonical coordinates (NCC) and the SQM is constructed in NCC. The map parameter of the SQM is used to represent the magnetic perturbation as in the Standard Map. The homoclinic tangle of the ideal separatrix of the SQM is calculated for different values of the map parameter. The parameters in the generating function of the SQM are so chosen that the height, the width, the elongation and the poloidal flux inside the separatrix is same as in the simple map. The purpose of this research is to compare the homoclinic tangle of the SQM with that of the simple map. The separatrix of the simple map is open and unbounded; while the separatrix of the SQM is closed and compact. Motivation is to see what role the topology of the separatrix plays in its homoclinic tangle in single-null divertor tokamaks. This work is supported by grants DE-FG02-01ER54624, DE-FG02-04ER54793, and DE-FG02-07ER54937.

  16. Conformational toggling controls target site choice for the heteromeric transposase element Tn7.

    Science.gov (United States)

    Shi, Qiaojuan; Straus, Marco R; Caron, Jeremy J; Wang, Huasheng; Chung, Yu Seon; Guarné, Alba; Peters, Joseph E

    2015-12-15

    The bacterial transposon Tn7 facilitates horizontal transfer by directing transposition into actively replicating DNA with the element-encoded protein TnsE. Structural analysis of the C-terminal domain of wild-type TnsE identified a novel protein fold including a central V-shaped loop that toggles between two distinct conformations. The structure of a robust TnsE gain-of-activity variant has this loop locked in a single conformation, suggesting that conformational flexibility regulates TnsE activity. Structure-based analysis of a series of TnsE mutants relates transposition activity to DNA binding stability. Wild-type TnsE appears to naturally form an unstable complex with a target DNA, whereas mutant combinations required for large changes in transposition frequency and targeting stabilized this interaction. Collectively, our work unveils a unique structural proofreading mechanism where toggling between two conformations regulates target commitment by limiting the stability of target DNA engagement until an appropriate insertion site is identified. PMID:26384427

  17. Tangle-Free Mesh Motion for Ablation Simulations

    Science.gov (United States)

    Droba, Justin

    2016-01-01

    Problems involving mesh motion-which should not be mistakenly associated with moving mesh methods, a class of adaptive mesh redistribution techniques-are of critical importance in numerical simulations of the thermal response of melting and ablative materials. Ablation is the process by which material vaporizes or otherwise erodes due to strong heating. Accurate modeling of such materials is of the utmost importance in design of passive thermal protection systems ("heatshields") for spacecraft, the layer of the vehicle that ensures survival of crew and craft during re-entry. In an explicit mesh motion approach, a complete thermal solve is first performed. Afterwards, the thermal response is used to determine surface recession rates. These values are then used to generate boundary conditions for an a posteriori correction designed to update the location of the mesh nodes. Most often, linear elastic or biharmonic equations are used to model this material response, traditionally in a finite element framework so that complex geometries can be simulated. A simple scheme for moving the boundary nodes involves receding along the surface normals. However, for all but the simplest problem geometries, evolution in time following such a scheme will eventually bring the mesh to intersect and "tangle" with itself, inducing failure. This presentation demonstrates a comprehensive and sophisticated scheme that analyzes the local geometry of each node with help from user-provided clues to eliminate the tangle and enable simulations on a wide-class of difficult problem geometries. The method developed is demonstrated for linear elastic equations but is general enough that it may be adapted to other modeling equations. The presentation will explicate the inner workings of the tangle-free mesh motion algorithm for both two and three-dimensional meshes. It will show abstract examples of the method's success, including a verification problem that demonstrates its accuracy and

  18. Design Optimization of Deflection Caused After Release of Multilayer Structural Membrane of Symmetric Toggle Switch

    Directory of Open Access Journals (Sweden)

    K. Maninder

    2011-01-01

    Full Text Available This paper presents the optimization in deflection caused by the inbuilt stress generated in mechanical or movable membrane of Symmetric Toggle RF MEMS Switch (STS. The movable membrane of STS was initially fabricated with two different materials, i.e. Chrome and Gold. The simulated deflection at 70 °C was 11.9 µm, and experimental deflection was 11-12 µm. We present a study of inbuilt deflection reduction in multimetal movable layers without change in actuation voltage of the switch. The design study was initially carried out on cantilevers and then on structural membrane of STS. STS with proposed multilayer of Cr-Au-Au-Ti-Au has a simulated deflection of 0.56 µm at 70 °C.

  19. Tangle-Free Finite Element Mesh Motion for Ablation Problems

    Science.gov (United States)

    Droba, Justin

    2016-01-01

    In numerical simulations involving boundaries that evolve in time, the primary challenge is updating the computational mesh to reflect the physical changes in the domain. In particular, the fundamental objective for any such \\mesh motion" scheme is to maintain mesh quality and suppress unphysical geometric anamolies and artifacts. External to a physical process of interest, mesh motion is an added component that determines the specifics of how to move the mesh given certain limited information from the main system. This paper develops a set of boundary conditions designed to eliminate tangling and internal collision within the context of PDE-based mesh motion (linear elasticity). These boundary conditions are developed for two- and three-dimensional meshes. The paper presents detailed algorithms for commonly occuring topological scenarios and explains how to apply them appropriately. Notably, the techniques discussed herein make use of none of the specifics of any particular formulation of mesh motion and thus are more broadly applicable. The two-dimensional algorithms are validated by an extensive verification procedure. Finally, many examples of diverse geometries in both two- and three-dimensions are shown to showcase the capabilities of the tangle-free boundary conditions.

  20. Septum Development in Neurospora crassa: The Septal Actomyosin Tangle

    Science.gov (United States)

    Delgado-Álvarez, Diego Luis; Bartnicki-García, Salomón; Seiler, Stephan; Mouriño-Pérez, Rosa Reyna

    2014-01-01

    Septum formation in Neurospora crassa was studied by fluorescent tagging of actin, myosin, tropomyosin, formin, fimbrin, BUD-4, and CHS-1. In chronological order, we recognized three septum development stages: 1) septal actomyosin tangle (SAT) assembly, 2) contractile actomyosin ring (CAR) formation, 3) CAR constriction together with plasma membrane ingrowth and cell wall construction. Septation began with the assembly of a conspicuous tangle of cortical actin cables (SAT) in the septation site >5 min before plasma membrane ingrowth. Tropomyosin and myosin were detected as components of the SAT from the outset. The SAT gradually condensed to form a proto-CAR that preceded CAR formation. During septum development, the contractile actomyosin ring remained associated with the advancing edge of the septum. Formin and BUD-4 were recruited during the transition from SAT to CAR and CHS-1 appeared two min before CAR constriction. Actin patches containing fimbrin were observed surrounding the ingrowing septum, an indication of endocytic activity. Although the trigger of SAT assembly remains unclear, the regularity of septation both in space and time gives us reason to believe that the initiation of the septation process is integrated with the mechanisms that control both the cell cycle and the overall growth of hyphae, despite the asynchronous nature of mitosis in N. crassa. PMID:24800890

  1. Computer-Aided Detection System on Tangled Roller

    Institute of Scientific and Technical Information of China (English)

    闫贺庆; 牛新文; 王成焘

    2004-01-01

    The mechanical-touched detector was used commonly in textile production limes. It has some defect with high false alarm rate, response delay and high maintenance cost. In order to overcome such defects, a new kind device was developed and used to detect roller tangled in the production lines. It is based on image processing. The core algorithm was composed of Canny edge detection, removing interference, detection of perpendicularity line and detection of broken tow. After the four steps, the broken tow could be recognized quickly and correctly. The algorithm is robust and high efficiency. So, the detection device has characteristic of stable, quickly-response and low maintains cost. It can keep superiority with long lifespan even in more formidable conditions. It guarantees a safe and stable production condition.

  2. Toggle PRM: Simultaneous mapping of C-free and C-obstacle - A study in 2D -

    KAUST Repository

    Denny, Jory

    2011-09-01

    Motion planning is known to be difficult. Probabilistic planners have made great advances, but still have difficulty for problems that require planning in narrow passages or on surfaces in Cspace. This work proposes Toggle PRM, a new methodology for PRMs that simultaneously maps both free and obstacle space. In this paper, we focus on 2 DOF problems and show that mapping both spaces leads to increased sampling density in narrow passages and to improved overall efficiency as compared to previous sampling based approaches.

  3. The design and analysis of a double swivel toggle release mechanism for the Orbiter stabilized payload deployment system

    Science.gov (United States)

    King, Guy L.; Tsai, Ted

    1989-01-01

    The NASA Stabilized Payload Deployment System (SPDS) is discussed. The lightweight and heavy-duty system rolls payloads over the orbiter's side rather than ejecting them upward. The system will enhance the orbiter capability of carrying larger and heavier payloads. The design, function, and analysis of a new three-pin double swivel toggle release mechanism which is crucial to the successful deployment of the SPDS are described.

  4. Monogamous nature of symmetric N-qubit states of the W class:Concurrence and negativity tangle

    Institute of Scientific and Technical Information of China (English)

    P. J. Geetha; K. O. Yashodamma; Sudha

    2015-01-01

    Using Majorana representation of symmetric N-qubit pure states, we have examined the monogamous nature of the family of states with two-distinct spinors, the W class of states. We have evaluated the N-concurrence tangle and showed that all the states in this family have vanishing concurrence tangle. The negativity tangle for the W class of states is shown to be non-zero, illustrating the fact that the concurrence tangle is always lesser than or equal to the negativity tangle in a pure N-qubit state.

  5. Transitions in genetic toggle switches driven by dynamic disorder in rate coefficients

    Science.gov (United States)

    Chen, Hang; Thill, Peter; Cao, Jianshu

    2016-05-01

    In biochemical systems, intrinsic noise may drive the system switch from one stable state to another. We investigate how kinetic switching between stable states in a bistable network is influenced by dynamic disorder, i.e., fluctuations in the rate coefficients. Using the geometric minimum action method, we first investigate the optimal transition paths and the corresponding minimum actions based on a genetic toggle switch model in which reaction coefficients draw from a discrete probability distribution. For the continuous probability distribution of the rate coefficient, we then consider two models of dynamic disorder in which reaction coefficients undergo different stochastic processes with the same stationary distribution. In one, the kinetic parameters follow a discrete Markov process and in the other they follow continuous Langevin dynamics. We find that regulation of the parameters modulating the dynamic disorder, as has been demonstrated to occur through allosteric control in bistable networks in the immune system, can be crucial in shaping the statistics of optimal transition paths, transition probabilities, and the stationary probability distribution of the network.

  6. Aversive Learning and Appetitive Motivation Toggle Feed-Forward Inhibition in the Drosophila Mushroom Body.

    Science.gov (United States)

    Perisse, Emmanuel; Owald, David; Barnstedt, Oliver; Talbot, Clifford B; Huetteroth, Wolf; Waddell, Scott

    2016-06-01

    In Drosophila, negatively reinforcing dopaminergic neurons also provide the inhibitory control of satiety over appetitive memory expression. Here we show that aversive learning causes a persistent depression of the conditioned odor drive to two downstream feed-forward inhibitory GABAergic interneurons of the mushroom body, called MVP2, or mushroom body output neuron (MBON)-γ1pedc>α/β. However, MVP2 neuron output is only essential for expression of short-term aversive memory. Stimulating MVP2 neurons preferentially inhibits the odor-evoked activity of avoidance-directing MBONs and odor-driven avoidance behavior, whereas their inhibition enhances odor avoidance. In contrast, odor-evoked activity of MVP2 neurons is elevated in hungry flies, and their feed-forward inhibition is required for expression of appetitive memory at all times. Moreover, imposing MVP2 activity promotes inappropriate appetitive memory expression in food-satiated flies. Aversive learning and appetitive motivation therefore toggle alternate modes of a common feed-forward inhibitory MVP2 pathway to promote conditioned odor avoidance or approach. PMID:27210550

  7. Transitions in genetic toggle switches driven by dynamic disorder in rate coefficients.

    Science.gov (United States)

    Chen, Hang; Thill, Peter; Cao, Jianshu

    2016-05-01

    In biochemical systems, intrinsic noise may drive the system switch from one stable state to another. We investigate how kinetic switching between stable states in a bistable network is influenced by dynamic disorder, i.e., fluctuations in the rate coefficients. Using the geometric minimum action method, we first investigate the optimal transition paths and the corresponding minimum actions based on a genetic toggle switch model in which reaction coefficients draw from a discrete probability distribution. For the continuous probability distribution of the rate coefficient, we then consider two models of dynamic disorder in which reaction coefficients undergo different stochastic processes with the same stationary distribution. In one, the kinetic parameters follow a discrete Markov process and in the other they follow continuous Langevin dynamics. We find that regulation of the parameters modulating the dynamic disorder, as has been demonstrated to occur through allosteric control in bistable networks in the immune system, can be crucial in shaping the statistics of optimal transition paths, transition probabilities, and the stationary probability distribution of the network. PMID:27155656

  8. Making Sense of the Tangle: Insights into Chromatin Folding and Gene Regulation.

    Science.gov (United States)

    Chung, Ill-Min; Ketharnathan, Sarada; Kim, Seung-Hyun; Thiruvengadam, Muthu; Rani, Mari Kavitha; Rajakumar, Govindasamy

    2016-01-01

    Proximity ligation assays such as circularized chromosome conformation capture and high-throughput chromosome capture assays have shed light on the structural organization of the interphase genome. Functional topologically associating domains (TADs) that constitute the building blocks of genomic organization are disrupted and reconstructed during the cell cycle. Epigenetic memory, as well as the sequence of chromosomes, regulate TAD reconstitution. Sub-TAD domains that are invariant across cell types have been identified, and contacts between these domains, rather than looping, are speculated to drive chromatin folding. Replication domains are established simultaneously with TADs during the cell cycle and the two correlate well in terms of characteristic features, such as lamin association and histone modifications. CCCTC-binding factor (CTCF) and cohesin cooperate across different cell types to regulate genes and genome organization. CTCF elements that demarcate TAD boundaries are commonly disrupted in cancer and promote oncogene activation. Chromatin looping facilitates interactions between distant promoters and enhancers, and the resulting enhanceosome complex promotes gene expression. Deciphering the chromatin tangle requires comprehensive integrative analyses of DNA- and protein-dependent factors that regulate genomic organization. PMID:27669308

  9. Making Sense of the Tangle: Insights into Chromatin Folding and Gene Regulation

    Directory of Open Access Journals (Sweden)

    Ill-Min Chung

    2016-09-01

    Full Text Available Proximity ligation assays such as circularized chromosome conformation capture and high-throughput chromosome capture assays have shed light on the structural organization of the interphase genome. Functional topologically associating domains (TADs that constitute the building blocks of genomic organization are disrupted and reconstructed during the cell cycle. Epigenetic memory, as well as the sequence of chromosomes, regulate TAD reconstitution. Sub-TAD domains that are invariant across cell types have been identified, and contacts between these domains, rather than looping, are speculated to drive chromatin folding. Replication domains are established simultaneously with TADs during the cell cycle and the two correlate well in terms of characteristic features, such as lamin association and histone modifications. CCCTC-binding factor (CTCF and cohesin cooperate across different cell types to regulate genes and genome organization. CTCF elements that demarcate TAD boundaries are commonly disrupted in cancer and promote oncogene activation. Chromatin looping facilitates interactions between distant promoters and enhancers, and the resulting enhanceosome complex promotes gene expression. Deciphering the chromatin tangle requires comprehensive integrative analyses of DNA- and protein-dependent factors that regulate genomic organization.

  10. Antibody meets the microbeam - or how to find neurofibrillary tangles

    International Nuclear Information System (INIS)

    In biomedical research the distributions of physiologically or pathologically active elements around or in a certain structure (e.g. tangles, plaques or different cell types) are often of great interest. Therefore, μPIXE analyses are applied to yield quantitative and spatially resolved concentration images of the elements of interest. However, the localisation of the structures to be examined is sometimes scarcely practicable or even impossible. This paper proposes a method of localising the areas of interest for μPIXE analysis. The method is based on the application of a suitable antibody tagged with a single elemental marker (e.g. Ni, Co, Cd, Ag or Au). The antibody then binds selectively to the structures of interest. The elemental marker is detectable via μPIXE, thus, showing finally the structure of interest via the bound antibody. The versatility of the antibodies in combination with the easily applied marker facilitates the localisation of a variety of structures in both light microscopy and μPIXE-imaging. The method is demonstrated on several cellular and subcellular structures in the brain. The elemental concentrations of two consecutive slices, one stained with Ni-enhanced antibody, the other unstained control, are compared to show the feasibility of trace elemental analysis for particular elements in spite if immunohistochemical structure identification. It has to be stated that the proposed technique will not work for free diffusing elements (like Na, Cl, K and Ca) whose concentrations can be altered by wet sample preparation

  11. Antibody meets the microbeam - or how to find neurofibrillary tangles

    Energy Technology Data Exchange (ETDEWEB)

    Morawski, Markus [Paul-Flechsig-Institut fuer Hirnforschung, Universitaet Leipzig, Jahnallee 59, 04109 Leipzig (Germany)]. E-mail: morm@medizin.uni-leipzig.de; Reinert, Tilo [Nukleare Festkoerperphysik, Universitaet Leipzig, Linnestr. 5, 04103 Leipzig (Germany); Meinecke, Christoph [Nukleare Festkoerperphysik, Universitaet Leipzig, Linnestr. 5, 04103 Leipzig (Germany); Arendt, Thomas [Paul-Flechsig-Institut fuer Hirnforschung, Universitaet Leipzig, Jahnallee 59, 04109 Leipzig (Germany); Butz, T. [Nukleare Festkoerperphysik, Universitaet Leipzig, Linnestr. 5, 04103 Leipzig (Germany)

    2005-04-01

    In biomedical research the distributions of physiologically or pathologically active elements around or in a certain structure (e.g. tangles, plaques or different cell types) are often of great interest. Therefore, {mu}PIXE analyses are applied to yield quantitative and spatially resolved concentration images of the elements of interest. However, the localisation of the structures to be examined is sometimes scarcely practicable or even impossible. This paper proposes a method of localising the areas of interest for {mu}PIXE analysis. The method is based on the application of a suitable antibody tagged with a single elemental marker (e.g. Ni, Co, Cd, Ag or Au). The antibody then binds selectively to the structures of interest. The elemental marker is detectable via {mu}PIXE, thus, showing finally the structure of interest via the bound antibody. The versatility of the antibodies in combination with the easily applied marker facilitates the localisation of a variety of structures in both light microscopy and {mu}PIXE-imaging. The method is demonstrated on several cellular and subcellular structures in the brain. The elemental concentrations of two consecutive slices, one stained with Ni-enhanced antibody, the other unstained control, are compared to show the feasibility of trace elemental analysis for particular elements in spite if immunohistochemical structure identification. It has to be stated that the proposed technique will not work for free diffusing elements (like Na, Cl, K and Ca) whose concentrations can be altered by wet sample preparation.

  12. Phosphatidylinositol-4,5-bisphosphate is enriched in granulovacuolar degeneration bodies and neurofibrillary tangles

    OpenAIRE

    Nishikawa, Tomokazu; Takahashi, Tetsuya; Nakamori, Masahiro; Yamazaki, Yu; Kurashige, Takashi; Nagano, Yoshito; Nishida, Yoshihiko; Izumi, Yuishin; Matsumoto, Masayasu

    2014-01-01

    Aims Among the pathological findings in Alzheimer’s disease (AD), the temporal and spatial profiles of granulovacuolar degeneration (GVD) bodies are characteristic in that they seem to be related to those of neurofibrillary tangles (NFTs), suggesting a common mechanism underlying the pathogenesis of these structures. Flotillin-1, a marker of lipid rafts, accumulates in lysosomes of tangle-bearing neurones in AD patients. In addition, recent reports have shown that GVD bodies accumulate at the...

  13. Four Ways to Get Tangled Up in Russian

    Directory of Open Access Journals (Sweden)

    Maria Nordrum

    2014-11-01

    Full Text Available In this paper I will analyze the four Natural Perfectives of the simplex verb путатьipf ‘tangle up’, namely впутатьpf, спутатьpf, перепутатьpf and запутатьpf. According to Janda et al. (2013:103, “prefix variation” is a phenomenon that applies to 27% of all Russian verbs and is caused by the ability of prefixes to “focus the meanings of a simplex verb in different ways” (op. cit.:162. My question is: Is it possible to predict the choice of prefix when there is prefix variation? And, if yes: How? My hypothesis is that the choice of prefix largely depends on the construction in which the verb appears and the semantics of its internal argument. Thus, I consider two factors in my analysis: Factor 1 Constructions and Factor 2 Semantics of the Internal Argument. My findings indicate that both factors are vital and, more specifically, that the choice of prefix for this verb to a large extent can be predicted by six tendencies that I will discuss thoroughly.I will argue that these six tendencies are of great relevance to second language learners, like myself, who often find themselves confused at the number of prefixes and, more specifically, Natural Perfectives available for a given verb. The topic of this paper has been born from a desire to gain insight with practical value in second language learning.

  14. Quorum-Sensing Synchronization of Synthetic Toggle Switches: A Design Based on Monotone Dynamical Systems Theory.

    Directory of Open Access Journals (Sweden)

    Evgeni V Nikolaev

    2016-04-01

    , performed for a biochemically-detailed and biologically-relevant model that we developed. Another novel feature of our approach is that our theorems on exponential stability of steady states for homogeneous or mixed populations are valid independently of the number N of cells in the population, which is usually very large (N ≫ 1 and unknown. We prove that the exponential stability depends on relative proportions of each type of state only. While monotone systems theory has been used previously for systems biology analysis, the current work illustrates its power for synthetic biology design, and thus has wider significance well beyond the application to the important problem of coordination of toggle switches.

  15. Quorum-Sensing Synchronization of Synthetic Toggle Switches: A Design Based on Monotone Dynamical Systems Theory.

    Science.gov (United States)

    Nikolaev, Evgeni V; Sontag, Eduardo D

    2016-04-01

    biochemically-detailed and biologically-relevant model that we developed. Another novel feature of our approach is that our theorems on exponential stability of steady states for homogeneous or mixed populations are valid independently of the number N of cells in the population, which is usually very large (N ≫ 1) and unknown. We prove that the exponential stability depends on relative proportions of each type of state only. While monotone systems theory has been used previously for systems biology analysis, the current work illustrates its power for synthetic biology design, and thus has wider significance well beyond the application to the important problem of coordination of toggle switches.

  16. Quorum-Sensing Synchronization of Synthetic Toggle Switches: A Design Based on Monotone Dynamical Systems Theory.

    Science.gov (United States)

    Nikolaev, Evgeni V; Sontag, Eduardo D

    2016-04-01

    biochemically-detailed and biologically-relevant model that we developed. Another novel feature of our approach is that our theorems on exponential stability of steady states for homogeneous or mixed populations are valid independently of the number N of cells in the population, which is usually very large (N ≫ 1) and unknown. We prove that the exponential stability depends on relative proportions of each type of state only. While monotone systems theory has been used previously for systems biology analysis, the current work illustrates its power for synthetic biology design, and thus has wider significance well beyond the application to the important problem of coordination of toggle switches. PMID:27128344

  17. Heteroclinic tangle phenomena in nanomagnets subject to time-harmonic excitations

    Energy Technology Data Exchange (ETDEWEB)

    Serpico, C.; Quercia, A.; Perna, S. [DIETI, Università di Napoli “Federico II,” I-80125 Napoli (Italy); Bertotti, G.; Ansalone, P. [Istituto Nazionale di Ricerca Metrologica, I-10135 Torino (Italy); D' Aquino, M. [Dip. di Ingegneria, Università di Napoli “Parthenope,” I-80143 Napoli (Italy); Mayergoyz, I. [ECE Department and UMIACS, University of Maryland, College Park, Maryland 20742 (United States)

    2015-05-07

    Magnetization dynamics in uniformly magnetized nanomagnets excited by time-harmonic (AC) external fields or spin-polarized injected currents is considered. The analysis is focused on the behaviour of the AC-excited dynamics near saddle equilibria. It turns out that this dynamics has a chaotic character at moderately low power level. This chaotic and fractal nature is due to the phenomenon of heteroclinic tangle which is produced by the combined effect of AC-excitations and saddle type dynamics. By using the perturbation technique based on Melnikov function, analytical formulas for the threshold AC excitation amplitudes necessary to create the heteroclinic tangle are derived. Both the cases of AC applied fields and AC spin-polarized injected currents are treated. Then, by means of numerical simulations, we show how heteroclinic tangle is accompanied by the erosion of the safe basin around the stable regimes.

  18. NMR Response of a Vortex Tangle in Rotating 3He-B

    International Nuclear Information System (INIS)

    Following the injection of vortex loops into an originally vortex-free sample of superfluid 3He-B at T < 0.6Tc, transient states appear which exhibit a modified response in transverse NMR experiments when compared with the response from the final equilibrium state of rectilinear vortices. Here we investigate the NMR response of a model state where a random vortex tangle is assumed to be superimposed on the equilibrium vortex state. We show that this model can qualitatively account for the experimental findings, provided that the tangle is anisotropic

  19. Alzheimer's disease: neuritic plaques and neurofibrillary tangles in human brain identified by FTIR spectroscopy

    Science.gov (United States)

    Choo, Lin-P'ing; Jackson, Michael; Halliday, William C.; Mantsch, Henry H.

    1994-01-01

    The abnormal abundance of (beta) -amyloid plaques and neurofibrillary tangles are the hallmark of Alzheimer's disease (AD). Human central nervous system (CNS) grey matter was probed for characteristics arising from these pathological features. In AD but not normal grey matter, an IR band at 1615 cm-1 is seen, characteristic of a protein in an aggregated state. We speculate that this band arises from (beta) A4-amyloid protein. AD, and 18q- grey matter spectra show increased intensity of phosphate bands in accordance with known hyperphosphorylation of proteins found in neurofibrillary tangles. These spectral features may be useful in the diagnosis of AD.

  20. Rapunzel Loves Merida: Melodramatic Expressions of Lesbian Girlhood and Teen Romance in Tangled, Brave, and Femslash.

    Science.gov (United States)

    Kapurch, Katie

    2015-01-01

    This article explores the melodramatic expression of lesbian girlhood and teen romance in Disney's Tangled (2010) and Disney Pixar's Brave (2012), as well as "Meripunzel" femslash, fan-authored romantic pairings of the animations' female protagonists. First, Anne Sexton's poem, "Rapunzel," offers a literary precedent for exploring lesbian themes in the fairy tale. The next section shows how Tangled and Brave invoke the narrative conventions of the family melodrama. This generic association reveals the films' uses of rhetoric familiar to youth coming-out narratives, as well as other visual and aural coding suggestive of queer styles. The last section shows how Meripunzel femslash taps into the films' existing melodramatic narrative forms and visual aesthetics, rehearsing their coming-out rhetoric while addressing the pleasures of and problems facing lesbian teen romance. I conclude by problematizing the often conventional expressions of lesbian girlhood in femslash, ultimately arguing for their empowering potential, especially as they indicate revised definitions of "princess." PMID:26264990

  1. Evolution of a superfluid vortex filament tangle driven by the Gross-Pitaevskii equation

    Science.gov (United States)

    Villois, Alberto; Proment, Davide; Krstulovic, Giorgio

    2016-06-01

    The development and decay of a turbulent vortex tangle driven by the Gross-Pitaevskii equation is studied. Using a recently developed accurate and robust tracking algorithm, all quantized vortices are extracted from the fields. The Vinen's decay law for the total vortex length with a coefficient that is in quantitative agreement with the values measured in helium II is observed. The topology of the tangle is then investigated showing that linked rings may appear during the evolution. The tracking also allows for determining the statistics of small-scale quantities of vortex lines, exhibiting large fluctuations of curvature and torsion. Finally, the temporal evolution of the Kelvin wave spectrum is obtained providing evidence of the development of a weak-wave turbulence cascade.

  2. Acceleration of raindrops formation due to tangling-clustering instability in turbulent stratified atmosphere

    CERN Document Server

    Elperin, T; Krasovitov, B; Kulmala, M; Liberman, M; Rogachevskii, I; Zilitinkevich, S

    2013-01-01

    Condensation of water vapor on active cloud condensation nuclei produces micron-size water droplets. To form rain, they must grow rapidly into at least 50-100 micron-size droplets. Observations show that this process takes only 15-20 minutes. The unexplained physical mechanism of such fast growth, is crucial for understanding and modeling of rain, and known as "condensation-coalescence bottleneck in rain formation". We show that the recently discovered phenomenon of the tangling clustering instability of small droplets in temperature-stratified turbulence (Phys. Fluids 25, 085104, 2013) results in the formation of droplet clusters with drastically increased droplet number densities and strong five-orders-of-magnitude enhancement of the collision-coalescence rate inside the clusters. The mechanism of tangling clustering instability in the temperature-stratified turbulence is much more effective than the previously considered pure inertial clustering caused by the centrifugal effect of turbulent vortices. Our a...

  3. Evolution of a superfluid vortex filament tangle driven by the Gross-Pitaevskii equation

    CERN Document Server

    Villois, Alberto; Krstulovic, Giorgio

    2016-01-01

    The development and decay of a turbulent vortex tangle driven by the Gross-Pitaevskii equation is studied. Using a recently-developed accurate and robust tracking algorithm, all quantised vortices are extracted from the fields. The Vinen's decay law for the total vortex length with a coefficient that is in quantitative agreement with the values measured in Helium II is observed. The topology of the tangle is then studied showing that linked rings may appear during the decay. The tracking also allows for determining the statistics of small-scales quantities of vortex lines, exhibiting large fluctuations of curvature and torsion. Finally, the temporal evolution of the Kelvin wave spectrum is obtained providing evidence of the development of a weak-wave turbulence cascade.

  4. Oriented Quantum Algebras and Coalgebras, Invariants of Oriented 1-1 Tangles, Knots and Links

    OpenAIRE

    Kauffman, Louis; Radford, David E.

    2010-01-01

    In this paper we study oriented quantum coalgebras which are structures closely related to oriented quantum algebras. We study the relationship between oriented quantum coalgebras and oriented quantum algebras and the relationship between oriented quantum coalgebras and quantum coalgebras. We show that there are regular isotopy invariants of oriented 1-1 tangles and of oriented knots and links associated to oriented and twist oriented quantum coalgebras respectively. There are many parallels ...

  5. Evolution and non-equilibrium physics. A study of the Tangled Nature Model

    OpenAIRE

    Becker, Nikolaj; Sibani, Paolo

    2013-01-01

    We argue that the stochastic dynamics of interacting agents which replicate, mutate and die constitutes a non-equilibrium physical process akin to aging in complex materials. Specifically, our study uses extensive computer simulations of the Tangled Nature Model (TNM) of biological evolution to show that punctuated equilibria successively generated by the model's dynamics have increasing entropy and are separated by increasing entropic barriers. We further show that these states are organized...

  6. Continuous variable tangle, monogamy inequality, and entanglement sharing in Gaussian states of continuous variable systems

    OpenAIRE

    Adesso, Gerardo; Illuminati, Fabrizio

    2004-01-01

    For continuous-variable systems, we introduce a measure of entanglement, the continuous variable tangle ({\\em contangle}), with the purpose of quantifying the distributed (shared) entanglement in multimode, multipartite Gaussian states. This is achieved by a proper convex roof extension of the squared logarithmic negativity. We prove that the contangle satisfies the Coffman-Kundu-Wootters monogamy inequality in all three--mode Gaussian states, and in all fully symmetric $N$--mode Gaussian sta...

  7. Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    Castellani Rudy J

    2008-09-01

    Full Text Available Abstract Alzheimer disease (AD is a chronic neurodegenerative disease that is characterized by progressive memory loss. Pathological markers of AD include neurofibrillary tangles, accumulation of amyloid-β plaques, neuronal loss, and inflammation. The exact events that lead to the neuronal dysfunction and loss are not completely understood. However, pro-inflammatory cytokines, such as interleukin-1β, interleukin-6, and tumor necrosis factor α, are increased in AD, along with gene expression of major histocompatibility complex (MHC class II molecules and macrophage migration inhibitory factor (MIF. MHC class II molecules are found in microglia of the brain, while MIF is found in both microglia and neurons of the hypothalamus, hippocampus, and cortex. MIF is not only a lymphocyte mediator but also a pituitary factor with endocrine properties and can mediate phosphorylation of the extracellular signal-regulated kinase-1/2 MAP kinases pathway. In this study, we looked at CD74, an integral membrane protein that acts as both a chaperone for MHC class II molecules as well as a receptor binding site for MIF. CD74 was recently found to be increased in microglia in AD cases compared to age-matched controls, but has not been reported in neurons. In our analysis, immunohistochemistry revealed a significant increase in CD74 primarily in neurofibrillary tangles, amyloid-β plaques, and microglia. This is the first finding to our knowledge that CD74 is increased in neurons of AD cases compared to age-matched control cases.

  8. Tangled Narratives and Wicked Problems: A Complex Case of Positioning and Politics in a Diverse School Community

    Science.gov (United States)

    Nguyen, Thu Suong Thi; Scribner, Samantha M. Paredes; Crow, Gary M.

    2012-01-01

    The case of Allen Elementary School presents tangled narratives and wicked problems describing the multidimensionality of school community work. Using multiple converging and diverging vignettes, the case points to the distinctiveness of individual experience in schools; the ways institutionalized organizational narratives become cultural…

  9. Evolution and non-equilibrium physics: A study of the Tangled Nature Model

    Science.gov (United States)

    Becker, Nikolaj; Sibani, Paolo

    2014-01-01

    We argue that the stochastic dynamics of interacting agents which replicate, mutate and die constitutes a non-equilibrium physical process akin to aging in complex materials. Specifically, our study uses extensive computer simulations of the Tangled Nature Model (TNM) of biological evolution to show that punctuated equilibria successively generated by the model's dynamics have increasing entropy and are separated by increasing entropic barriers. We further show that these states are organized in a hierarchy and that limiting the values of possible interactions to a finite interval leads to stationary fluctuations within a component of the latter. A coarse-grained description based on the temporal statistics of quakes, the events leading from one component of the hierarchy to the next, accounts for the logarithmic growth of the population and the decaying rate of change of macroscopic variables. Finally, we question the role of fitness in large-scale evolution models and speculate on the possible evolutionary role of rejuvenation and memory effects.

  10. Vortex arrays and ciliary tangles underlie the feeding-swimming tradeoff in starfish larvae

    CERN Document Server

    Gilpin, William; Prakash, Manu

    2016-01-01

    Many marine invertebrates have larval stages covered in linear arrays of beating cilia, which propel the animal while simultaneously entraining planktonic prey. These bands are strongly conserved across taxa spanning four major superphyla, and they are responsible for the unusual morphologies of many invertebrates. However, few studies have investigated their underlying hydrodynamics. Here, we study the ciliary bands of starfish larvae, and discover a beautiful pattern of slowly-evolving vortices that surrounds the swimming animals. Closer inspection of the bands reveals unusual ciliary "tangles" analogous to topological defects that break-up and re-form as the animal adjusts its swimming stroke. Quantitative experiments and modeling suggest that these vortices create a physical tradeoff between feeding and swimming, which manifests as distinct flow patterns or "eigenstrokes" representing each behavior---potentially implicating neuronal control of cilia. This quantitative interplay between larval form and hyd...

  11. In vitro and in vivo genotoxic effects of straight versus tangled multi-walled carbon nanotubes.

    Science.gov (United States)

    Catalán, Julia; Siivola, Kirsi M; Nymark, Penny; Lindberg, Hanna; Suhonen, Satu; Järventaus, Hilkka; Koivisto, Antti J; Moreno, Carlos; Vanhala, Esa; Wolff, Henrik; Kling, Kirsten I; Jensen, Keld Alstrup; Savolainen, Kai; Norppa, Hannu

    2016-08-01

    Some multi-walled carbon nanotubes (MWCNTs) induce mesothelioma in rodents, straight MWCNTs showing a more pronounced effect than tangled MWCNTs. As primary and secondary genotoxicity may play a role in MWCNT carcinogenesis, we used a battery of assays for DNA damage and micronuclei to compare the genotoxicity of straight (MWCNT-S) and tangled MWCNTs (MWCNT-T) in vitro (primary genotoxicity) and in vivo (primary or secondary genotoxicity). C57Bl/6 mice showed a dose-dependent increase in DNA strand breaks, as measured by the comet assay, in lung cells 24 h after a single pharyngeal aspiration of MWCNT-S (1-200 μg/mouse). An increase was also observed for DNA strand breaks in lung and bronchoalveolar lavage (BAL) cells and for micronucleated alveolar type II cells in mice exposed to aerosolized MWCNT-S (8.2-10.8 mg/m(3)) for 4 d, 4 h/d. No systemic genotoxic effects, assessed by the γ-H2AX assay in blood mononuclear leukocytes or by micronucleated polychromatic erythrocytes (MNPCEs) in bone marrow or blood, were observed for MWCNT-S by either exposure technique. MWCNT-T showed a dose-related decrease in DNA damage in BAL and lung cells of mice after a single pharyngeal aspiration (1-200 μg/mouse) and in MNPCEs after inhalation exposure (17.5 mg/m(3)). In vitro in human bronchial epithelial BEAS-2B cells, MWCNT-S induced DNA strand breaks at low doses (5 and 10 μg/cm(2)), while MWCNT-T increased strand breakage only at 200 μg/cm(2). Neither of the MWCNTs was able to induce micronuclei in vitro. Our findings suggest that both primary and secondary mechanisms may be involved in the genotoxicity of straight MWCNTs. PMID:26674712

  12. Axion production and CMB spectral distortion in cosmological tangled magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Ejlli, Damian [INFN Laboratori Nazionali del Gran Sasso, Theory group, Assergi, L' Aquila (Italy); Novosibirsk State University, Department of Physics, Novosibirsk (Russian Federation)

    2015-08-15

    Axion production due to photon-axion mixing in tangled magnetic fields prior to the recombination epoch and magnetic field damping can generate cosmic microwave background (CMB) spectral distortions. In particular, the contribution of both processes to the CMB μ distortion in the case of resonant photon-axion mixing is studied. Assuming that the magnetic field power spectrum is approximated by a power law, P{sub B}(k)∝k{sup n} with spectral index n, it is shown that for magnetic field cut-off scales 172.5 pc ≤ λ{sub B} ≤ 4 x 10{sup 3} pc, the axion contribution to the CMB μ distortion is subdominant in comparison with magnetic field damping in the cosmological plasma. Using the COBE upper limit on μ and for the magnetic field scale λ{sub B} ≅ 415 pc, a weaker limit in comparison with other studies on the magnetic field strength (B{sub 0} ≤ 8.5 @ x 10{sup -8} G) up to a factor 10 for the DFSZ axion model and axion mass m{sub a} ≥ 2.6 @ x 10{sup -6} eV is found. A forecast for the expected sensitivity of PIXIE/PRISM on μ is also presented. (orig.)

  13. Lhermitte-Duclos disease with neurofibrillary tangles in heterotopic cerebral grey matter.

    Science.gov (United States)

    Rusiecki, D; Lach, B

    2016-01-01

    Lhermitte-Duclos disease (LDD), a disorder first described by French physicians Lhermitte and Duclos in 1920 [25], is a benign, slow growing dysplastic gangliocytoma of the cerebellum, characterized by replacement of the granule cell layer by abnormal granule and Purkinje like cells. The most frequent presenting signs and symptoms are megalocephaly, increased intracranial pressure, nausea, hydrocephalus, ataxia, gait abnormalities, and intermittent headaches, all of which are attributed to the mass effect [6,11,25]. Many cases are associated with a mutation in the phosphatase and tensin homolog or PTEN gene which is also involved in numerous otherwise unrelated central nervous system abnormalities, namely Cowden syndrome [1,6,11], autism spectrum disorder [18], cerebral cortical dysplasia [11,30] and Bannayan-Riley-Ruvalcaba syndrome [30]. The presence of cortical heterotopia has been reported in a small number of LDD cases [3,5,17,32]. We describe a unique case of LDD with cerebral cortical heterotopic grey matter containing neurofibrillary tangles. PMID:27543776

  14. Continuous variable tangle, monogamy inequality, and entanglement sharing in Gaussian states of continuous variable systems

    International Nuclear Information System (INIS)

    For continuous-variable (CV) systems, we introduce a measure of entanglement, the CV tangle (contangle), with the purpose of quantifying the distributed (shared) entanglement in multimode, multipartite Gaussian states. This is achieved by a proper convex-roof extension of the squared logarithmic negativity. We prove that the contangle satisfies the Coffman-Kundu-Wootters monogamy inequality in all three-mode Gaussian states, and in all fully symmetric N-mode Gaussian states, for arbitrary N. For three-mode pure states, we prove that the residual entanglement is a genuine tripartite entanglement monotone under Gaussian local operations and classical communication. We show that pure, symmetric three-mode Gaussian states allow a promiscuous entanglement sharing, having both maximum tripartite residual entanglement and maximum couplewise entanglement between any pair of modes. These states are thus simultaneous CV analogues of both the GHZ and the W states of three qubits: in CV systems monogamy does not prevent promiscuity, and the inequivalence between different classes of maximally entangled states, holding for systems of three or more qubits, is removed

  15. Tangled nature model of evolutionary dynamics reconsidered: Structural and dynamical effects of trait inheritance

    Science.gov (United States)

    Andersen, Christian Walther; Sibani, Paolo

    2016-05-01

    Based on the stochastic dynamics of interacting agents which reproduce, mutate, and die, the tangled nature model (TNM) describes key emergent features of biological and cultural ecosystems' evolution. While trait inheritance is not included in many applications, i.e., the interactions of an agent and those of its mutated offspring are taken to be uncorrelated, in the family of TNMs introduced in this work correlations of varying strength are parametrized by a positive integer K . We first show that the interactions generated by our rule are nearly independent of K . Consequently, the structural and dynamical effects of trait inheritance can be studied independently of effects related to the form of the interactions. We then show that changing K strengthens the core structure of the ecology, leads to population abundance distributions better approximated by log-normal probability densities, and increases the probability that a species extant at time tw also survives at t >tw . Finally, survival probabilities of species are shown to decay as powers of the ratio t /tw , a so-called pure aging behavior usually seen in glassy systems of physical origin. We find a quantitative dynamical effect of trait inheritance, namely, that increasing the value of K numerically decreases the decay exponent of the species survival probability.

  16. Axion production and CMB spectral distortion in cosmological tangled magnetic field

    CERN Document Server

    Ejlli, Damian

    2015-01-01

    Axion production due to photon-axion mixing in tangled magnetic field(s) prior to recombination epoch and magnetic field damping can generate cosmic microwave background (CMB) spectral distortions. In particular, contribution of both processes to CMB $\\mu$ distortion in the case of resonant photon-axion mixing is studied. Assuming that magnetic field power spectrum is approximated by a power law $P_B(k)\\propto k^n$ with spectral index $n$, it is shown that for magnetic field cut-off scales $172.5$ pc $\\leq \\lambda_B\\leq 4\\times 10^3$ pc, axion contribution to CMB $\\mu$ distortion is subdominant in comparison with magnetic field damping in the cosmological plasma. Using COBE upper limit on $\\mu$ and for magnetic field scale $\\lambda_B\\simeq 415$ pc, weaker limit in comparison with other studies on the magnetic field strength ($B_0\\leq 8.5\\times 10^{-8}$ G) up to a factor 10 for the DFSZ axion model and axion mass $m_a\\geq 2.6\\times 10^{-6}$ eV is found. A forecast for the expected sensitivity of PIXIE/PRISM on...

  17. Continuous variable tangle, monogamy inequality, and entanglement sharing in Gaussian states of continuous variable systems

    Energy Technology Data Exchange (ETDEWEB)

    Adesso, Gerardo; Illuminati, Fabrizio [Dipartimento di Fisica ' E R Caianiello' , Universita degli Studi di Salerno (Italy); CNISM and CNR-Coherentia, Gruppo di Salerno (Italy); and INFN Sezione di Napoli-Gruppo Collegato di Salerno (Italy); Via S Allende, 84081 Baronissi, SA (Italy)

    2006-01-15

    For continuous-variable (CV) systems, we introduce a measure of entanglement, the CV tangle (contangle), with the purpose of quantifying the distributed (shared) entanglement in multimode, multipartite Gaussian states. This is achieved by a proper convex-roof extension of the squared logarithmic negativity. We prove that the contangle satisfies the Coffman-Kundu-Wootters monogamy inequality in all three-mode Gaussian states, and in all fully symmetric N-mode Gaussian states, for arbitrary N. For three-mode pure states, we prove that the residual entanglement is a genuine tripartite entanglement monotone under Gaussian local operations and classical communication. We show that pure, symmetric three-mode Gaussian states allow a promiscuous entanglement sharing, having both maximum tripartite residual entanglement and maximum couplewise entanglement between any pair of modes. These states are thus simultaneous CV analogues of both the GHZ and the W states of three qubits: in CV systems monogamy does not prevent promiscuity, and the inequivalence between different classes of maximally entangled states, holding for systems of three or more qubits, is removed.

  18. A circadian clock-regulated toggle switch explains AtGRP7 and AtGRP8 oscillations in Arabidopsis thaliana.

    Directory of Open Access Journals (Sweden)

    Christoph Schmal

    Full Text Available The circadian clock controls many physiological processes in higher plants and causes a large fraction of the genome to be expressed with a 24h rhythm. The transcripts encoding the RNA-binding proteins AtGRP7 (Arabidopsis thaliana Glycine Rich Protein 7 and AtGRP8 oscillate with evening peaks. The circadian clock components CCA1 and LHY negatively affect AtGRP7 expression at the level of transcription. AtGRP7 and AtGRP8, in turn, negatively auto-regulate and reciprocally cross-regulate post-transcriptionally: high protein levels promote the generation of an alternative splice form that is rapidly degraded. This clock-regulated feedback loop has been proposed to act as a molecular slave oscillator in clock output. While mathematical models describing the circadian core oscillator in Arabidopsis thaliana were introduced recently, we propose here the first model of a circadian slave oscillator. We define the slave oscillator in terms of ordinary differential equations and identify the model's parameters by an optimization procedure based on experimental results. The model successfully reproduces the pertinent experimental findings such as waveforms, phases, and half-lives of the time-dependent concentrations. Furthermore, we obtain insights into possible mechanisms underlying the observed experimental dynamics: the negative auto-regulation and reciprocal cross-regulation via alternative splicing could be responsible for the sharply peaking waveforms of the AtGRP7 and AtGRP8 mRNA. Moreover, our results suggest that the AtGRP8 transcript oscillations are subordinated to those of AtGRP7 due to a higher impact of AtGRP7 protein on alternative splicing of its own and of the AtGRP8 pre-mRNA compared to the impact of AtGRP8 protein. Importantly, a bifurcation analysis provides theoretical evidence that the slave oscillator could be a toggle switch, arising from the reciprocal cross-regulation at the post-transcriptional level. In view of this

  19. Highly Selective Tau-SPECT Imaging Probes for Detection of Neurofibrillary Tangles in Alzheimer’s Disease

    Science.gov (United States)

    Ono, Masahiro; Watanabe, Hiroyuki; Kitada, Ayane; Matsumura, Kenji; Ihara, Masafumi; Saji, Hideo

    2016-01-01

    Neurofibrillary tangles composed of aggregates of hyperphosphorylated tau proteins are one of the neuropathological hallmarks of Alzheimer’s disease (AD) in addition to the deposition of β-amyloid plaques. Since the deposition of tau aggregates is closely associated with the severity of AD, the in vivo detection of tau aggregates may be useful as a biomarker for the diagnosis and progression of AD. In this study, we designed and synthesized a new series of radioiodinated benzoimidazopyridine (BIP) derivatives, and evaluated their utility as single photon emission computed tomography (SPECT) imaging agents targeting tau aggregates in AD brains. Five radioiodinated BIP derivatives were successfully prepared in high radiochemical yields and purities. In in vitro autoradiographic studies using postmortem AD brains, all BIP derivatives displayed high accumulation of radioactivity in the brain sections with abundant neurofibrillary tangles, while no marked radioactivity accumulation was observed in the brain sections with only β-amyloid aggregates, indicating that the BIP derivatives exhibited selective binding to tau aggregates. Biodistribution studies in normal mice showed high brain uptake at 2 min postinjection (3.5–4.7% ID/g) and rapid clearance at 60 min postinjection (0.04–0.23% ID/g), which is highly desirable for tau imaging agents. The results of the present study suggest that [123I]BIP derivatives may be useful SPECT agents for the in vivo imaging of tau aggregates in AD. PMID:27687137

  20. On the freeness of the cyclotomic BMW algebras: admissibility and an isomorphism with the cyclotomic Kauffman tangle algebras

    CERN Document Server

    Wilcox, Stewart

    2009-01-01

    The cyclotomic Birman-Murakami-Wenzl (BMW) algebras B_n^k, introduced by R. H\\"aring-Oldenburg, are a generalisation of the BMW algebras associated with the cyclotomic Hecke algebras of type G(k,1,n) (aka Ariki-Koike algebras) and type B knot theory. In this paper, we prove the algebra is free and of rank k^n (2n-1)!! over ground rings with parameters satisfying so-called "admissibility conditions". These conditions are necessary in order for these results to hold and originally arise from the representation theory of B_2^k, which is analysed by the authors in a previous paper. Furthermore, we obtain a geometric realisation of B_n^k as a cyclotomic version of the Kauffman tangle algebra, in terms of affine n-tangles in the solid torus, and produce explicit bases that may be described both algebraically and diagrammatically. The admissibility conditions are the most general offered in the literature for which these results hold; they are necessary and sufficient for all results for general n.

  1. 机械式压力机曲柄六杆机构运动学特性分析%Kinematic Characteristics Analysis of Crank Toggle Transmission Mechanism in Mechanical Press

    Institute of Scientific and Technical Information of China (English)

    王粟; 覃岭; 阮卫平; 伍伟杰; 胡建国

    2011-01-01

    与曲柄连杆滑块机构相比,以曲柄六杆作为组合传动机构的终级输出构件向工作机构(滑块)传递运动和动力具有一些较好的特性.曲柄六杆传动机构中主动件与运动输出滑块之间的位置、速度及加速度关系是机构运动学分析、机械机构设计的基础.对机械压力机曲柄六杆传动机构各构件的运动学特性从理论上进行了分析,建立了理论分析计算公式,并进行了仿真模拟,对该类机构的进一步研究分析具有重要意义.%Compared with crank and slider mechanism, the ultimate output component with crank toggle as a combination transmission mechanism has some better characteristics for transmitting movement and force. The relation of position, speed and acceleration between driving part and output slider in the crank toggle transmission mechanism is the base of the mechanism's kinematic analysis and machine design. Every component' s kinematic characteristics in the crank toggle transmission mechanism of the mechanical press is analyzed, their theoretical formula is establish and simulation is carried out. This study is quite useful for further research and analysis of this type of mechanism.

  2. Biondi ring tangles in the choroid plexus of Alzheimer's disease and normal aging brains: a quantitative study.

    Science.gov (United States)

    Wen, G Y; Wisniewski, H M; Kascsak, R J

    1999-06-19

    The choroid plexus (CP) performs the vital function of producing up to 90% (450-1000 ml/day) of cerebrospinal fluid (CSF) to nourish and to protect the brain in the CSF suspension. The CP also acts as a selective barrier between blood and CSF to regulate ions and other essential molecules. However, the accumulation of intracellular inclusions called Biondi ring tangles (BRTs) in CP cells of Alzheimer's disease (AD)/aging brains may affect these vital functions of the CP. Statistical analysis of quantitative data on the numbers of CP cells containing BRTs from 54 brains (29 AD and 25 normal control), age range 1-100 years, indicated a significant difference (pbiomarker for AD in addition to NPs and NFTs.

  3. Angiomyomatous hamartoma in an inguinal lymph node with proliferating pericytes/smooth muscle cells, plexiform vessel tangles, and ectopic calcification

    Directory of Open Access Journals (Sweden)

    Chii-Hong Lee

    2015-01-01

    Full Text Available Angiomyomatous hamartoma (AMH is a rare benign lesion, which occurs almost exclusively in the inguinal lymph nodes. We herein report a case of a female elder who presented with a long-standing inguinal mass. Microscopically, the mass showed a zonal distribution, characterized by thick-walled muscular vessels, fibrosis, and calcification in the hilum and proliferating spindle cells around thin-walled vessels and plexiform vessel tangles at the periphery. The spindle cells show positive immunoreactivity of smooth muscle actin and CD34 with a heterogeneous expression of desmin and CD44. Although the pathogenesis of AMH remains uncertain, the histological features and immunohistochemical findings of this case imply a disordered or exuberant angiogenic process.

  4. Tangled up in knots – Structures of inactivated forms of E. coli class Ia Ribonucleotide Reductase

    OpenAIRE

    Zimanyi, Christina M.; Ando, Nozomi; Brignole, Edward J; Asturias, Francisco J; Stubbe, JoAnne; Drennan, Catherine L.

    2012-01-01

    Successful targets for anti-cancer drugs such as clofarabine and gemcitabine, ribonucleotide reductases (RNRs) provide the precursors for DNA biosynthesis and repair. Recently, we reported that dATP inhibits E. coli class Ia RNR by driving formation of RNR subunits into α4β4 rings. Here, we present the first X-ray structure of gemcitabine-inhibited E. coli RNR and show that the previously described α4β4 rings can interlock to form an unprecedented (α4β4)2 megacomplex. This complex is also see...

  5. 二阶可逆耦合触发细胞自动机的加密技术研究%Two-order Reversible Couple Toggle Cellular Automata Based Image Encryption Algorithm

    Institute of Scientific and Technical Information of China (English)

    彭川

    2012-01-01

    为了有效改进细胞自动机加密系统的实现复杂度和加解密效率,提出了一种二阶可逆耦合触发细胞自动机的图像加密方法.通过对简单的可逆细胞自动机进行扩展,构造二阶可逆细胞自动机,并以耦合触发规则对明文图像实行分块加密.二阶可逆细胞自动机的转移状态由其当前状态以及前一状态决定,有效增大了邻域范围,并且因为采用耦合触发规则,因此能明显增大加密系统的密钥空间,保证了系统的计算安全性.与一般触发自动机反向迭代的串行加密方式相比,该方法对于每个细胞的加密具有本质并行性,因此具有极高的加解密效率.通过实验验证其性能,结果表明与其它算法相比,该算法具有较大的密钥空间,能够有效抵抗蛮力攻击和差分分析攻击,且较小的邻域半径即可得到良好的加密效果,因此非常便于硬件实现.%To effectively improve the implement complexity and execution efficiency, an algorithm for image encryption is proposed which is based on two-order reversible couple toggle cellular automata (CA). By ways that extending the structure of simple reversible CA (RCA) and adopting couple toggle rules, the algorithm ciphers image which is divided into blocks previously. The CA's state is determined by previous state and next state, so it has larger key space and this can make system safe enough. Compared with general toggle CA (TCA) methods, the algorithm has much better efficiency because each cell is updated parallel Experiments and analysis indicate that this method has an enough large key space, high cipher and decipher speed and good scrambling effect. And the cryptosystem can resist brute attack and differential attack effectively.

  6. Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease.

    Science.gov (United States)

    Basurto-Islas, Gustavo; Luna-Muñoz, Jose; Guillozet-Bongaarts, Angela L; Binder, Lester I; Mena, Raul; García-Sierra, Francisco

    2008-05-01

    Truncations of tau protein at aspartic acid421 (D421) and glutamic acid391 (E391) residues are associated with neurofibrillary tangles (NFTs) in the brains of Alzheimer disease (AD) patients. Using immunohistochemistry with antibodies to D421- and E391-truncated tau (Tau-C3 and MN423, respectively), we correlated the presence of NFTs composed of these truncated tau proteins with clinical and neuropathologic parameters in 17 AD and 23 non-AD control brains. The densities of NFTs composed of D421- or E391-truncated tau correlated with clinical dementia index and Braak staging in AD. Glutamic acid391 tau truncation was prominent in the entorhinal cortex, whereas D421 truncation was prominent in the subiculum, suggesting that NFTs composed of either D421- or E391-truncated tau may be formed mutually exclusively in these areas. Both truncations were associated with the prevalence of the apolipoprotein E epsilon4 allele. By double labeling, intact tau in NFTs was commonly associated with D421-cleaved tau but not with E391-truncated tau; D421-cleaved tau was never associated with E391-truncated tau. These results indicate that tau is not randomly proteolyzed at different domains, and that proteolysis occurs sequentially from the C-terminus to inner regions of tau in AD progression. Identification of NFTs composed of tau at different stages of truncation may facilitate assessment of neurofibrillary pathology in AD.

  7. A new way to contemplate Darwin's tangled bank: how DNA barcodes are reconnecting biodiversity science and biomonitoring.

    Science.gov (United States)

    Hajibabaei, Mehrdad; Baird, Donald J; Fahner, Nicole A; Beiko, Robert; Golding, G Brian

    2016-09-01

    Encompassing the breadth of biodiversity in biomonitoring programmes has been frustrated by an inability to simultaneously identify large numbers of species accurately and in a timely fashion. Biomonitoring infers the state of an ecosystem from samples collected and identified using the best available taxonomic knowledge. The advent of DNA barcoding has now given way to the extraction of bulk DNA from mixed samples of organisms in environmental samples through the development of high-throughput sequencing (HTS). This DNA metabarcoding approach allows an unprecedented view of the true breadth and depth of biodiversity, but its adoption poses two important challenges. First, bioinformatics techniques must simultaneously perform complex analyses of large datasets and translate the results of these analyses to a range of users. Second, the insights gained from HTS need to be amalgamated with concepts such as Linnaean taxonomy and indicator species, which are less comprehensive but more intuitive. It is clear that we are moving beyond proof-of-concept studies to address the challenge of implementation of this new approach for environmental monitoring and regulation. Interpreting Darwin's 'tangled bank' through a DNA lens is now a reality, but the question remains: how can this information be generated and used reliably, and how does it relate to accepted norms in ecosystem study?This article is part of the themed issue 'From DNA barcodes to biomes'. PMID:27481782

  8. Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles.

    Directory of Open Access Journals (Sweden)

    Jin Chu

    Full Text Available The 5-lipoxygenase (5LO enzyme is widely distributed within the central nervous system. Previous works showed that this protein is up-regulated in Alzheimer's disease (AD, and plays an active role in the development of brain amyloidosis in the APP transgenic mice. In the present paper, we studied the effect of its pharmacological inhibition on the entire AD-like phenotype of a mouse model with plaques and tangles, the 3 × Tg mice. Compared with mice receiving placebo, the group treated with zileuton, a specific 5LO inhibitor, manifested a significant improvement of their memory impairments. The same animals had a significant reduction in Aβ levels and deposition, which was secondary to a down-regulation of the γ-secretase pathway. Additionally, while total tau levels were unchanged for both groups, zileuton-treated mice had a significant reduction in its phosphorylation state and insoluble forms, secondary to a decreased activation of the cdk5 kinase. These data establish a functional role for 5LO in the pathogenesis of the full spectrum of the AD-like phenotype and represent the successful completion of the initial step for the preclinical development of 5LO inhibitors as viable therapeutic agents for AD.

  9. A new way to contemplate Darwin's tangled bank: how DNA barcodes are reconnecting biodiversity science and biomonitoring

    Science.gov (United States)

    Baird, Donald J.; Fahner, Nicole A.; Beiko, Robert; Golding, G. Brian

    2016-01-01

    Encompassing the breadth of biodiversity in biomonitoring programmes has been frustrated by an inability to simultaneously identify large numbers of species accurately and in a timely fashion. Biomonitoring infers the state of an ecosystem from samples collected and identified using the best available taxonomic knowledge. The advent of DNA barcoding has now given way to the extraction of bulk DNA from mixed samples of organisms in environmental samples through the development of high-throughput sequencing (HTS). This DNA metabarcoding approach allows an unprecedented view of the true breadth and depth of biodiversity, but its adoption poses two important challenges. First, bioinformatics techniques must simultaneously perform complex analyses of large datasets and translate the results of these analyses to a range of users. Second, the insights gained from HTS need to be amalgamated with concepts such as Linnaean taxonomy and indicator species, which are less comprehensive but more intuitive. It is clear that we are moving beyond proof-of-concept studies to address the challenge of implementation of this new approach for environmental monitoring and regulation. Interpreting Darwin's ‘tangled bank’ through a DNA lens is now a reality, but the question remains: how can this information be generated and used reliably, and how does it relate to accepted norms in ecosystem study? This article is part of the themed issue ‘From DNA barcodes to biomes’. PMID:27481782

  10. Cancer

    Science.gov (United States)

    ... Blood tests (which look for chemicals such as tumor markers) Bone marrow biopsy (for lymphoma or leukemia) Chest ... the case with skin cancers , as well as cancers of the lung, breast, and colon. If the tumor has spread ...

  11. Cancer

    Science.gov (United States)

    Cancer begins in your cells, which are the building blocks of your body. Normally, your body forms ... be benign or malignant. Benign tumors aren't cancer while malignant ones are. Cells from malignant tumors ...

  12. Quantification of immunohistochemical findings of neurofibrillary tangles and senile plaques for a diagnosis of dementia in forensic autopsy cases.

    Science.gov (United States)

    Takayama, Mio; Kashiwagi, Masayuki; Matsusue, Aya; Waters, Brian; Hara, Kenji; Ikematsu, Natsuki; Kubo, Shin-Ichi

    2016-09-01

    We report the quantification of immunohistochemical findings for a diagnosis of dementia in autopsy cases among older decedents. Autopsy cases were selected with the following requirements: >65yo; no head injuries, thermal injuries, or heat stroke; no intracranial lesions; and within 48h of death. Among cases that met all requirements, 10 had a clinical diagnosis of dementia were included in dementia group. Non-dementia group consisted of 38 cases without any record of dementia. To compare these groups, immunohistochemically, beta-amyloid, tau protein, gephyrin, and IL-33 were examined in five regions. Quantitative analysis was performed by collecting with image data analyzed using analysis software. Image data on tau-immunopositive neurofibrillary tangles (NFT) and beta-amyloid-positive senile plaques (SP) were photographed. Criteria for dementia were made by counting and measuring NFT and SP from image data using software. Differences in SP and NFT were effective for discriminating between the two groups. These criteria may reveal the presence and progression of dementia. Total of tau-positive NFT in Ammon's horn (AH) may be useful for diagnosing dementia. When the total is more than 41 in approximately 6mm(2) of AH, the possibility of dementia is considered. Total of beta-amyloid-positive SP in the parahippocampal gyrus (PHG) may be useful for diagnosing dementia. When the total in approximately 5mm(2) of PHG is more than 47, the possibility of dementia is considered. Immunohistochemical staining may be more useful for obtaining image data for quantification than conventional staining techniques, such as Bielschowsky-Hirano's silver staining. PMID:27591545

  13. A traumatic neuroma in breast cancer patient after mastectomy: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Su Young [Dept. of Radiology, Dong-A University College of Medicine, Busan , (Korea, Republic of)

    2013-11-15

    A traumatic neuroma is a tangle of neural fibers and connective tissues which develop at the end of a proximal nerve stump following the nerve injury. The incidence of traumatic neuroma after breast cancer surgery is extremely low, and so far, there are only 11 cases being reported in literature. We present sonographic and pathologic features of a traumatic neuroma that mimics the recurrent breast carcinoma identified on follow-up ultrasound examinations after breast cancer surgery.

  14. [Cancer].

    Science.gov (United States)

    de la Peña-López, Roberto; Remolina-Bonilla, Yuly Andrea

    2016-09-01

    Cancer is a group of diseases which represents a significant public health problem in Mexico and worldwide. In Mexico neoplasms are the second leading cause of death. An increased morbidity and mortality are expected in the next decades. Several preventable risk factors for cancer development have been identified, the most relevant including tobacco use, which accounts for 30% of the cancer cases; and obesity, associated to another 30%. These factors, in turn, are related to sedentarism, alcohol abuse and imbalanced diets. Some agents are well knokn to cause cancer such as ionizing radiation, viruses such as the papilloma virus (HPV) and hepatitis virus (B and C), and more recently environmental pollution exposure and red meat consumption have been pointed out as carcinogens by the International Agency for Research in Cancer (IARC). The scientific evidence currently available is insufficient to consider milk either as a risk factor or protective factor against different types of cancer. PMID:27603890

  15. Effect of Sea Tangle (Laminaria japonica) and Charcoal Supplementation as Alternatives to Antibiotics on Growth Performance and Meat Quality of Ducks.

    Science.gov (United States)

    Islam, M M; Ahmed, S T; Kim, Y J; Mun, H S; Kim, Y J; Yang, C J

    2014-02-01

    A total of 150 growing ducks were assigned to five dietary treatments to study the effect of sea tangle and charcoal (STC) supplementation on growth performance and meat characteristics in a completely randomized design. There were six replicates and five ducklings in each replication. The five dietary treatments were control, antibiotic, and 0.1%, 0.5%, and 1% STC supplemented diets. No significant differences were found on ADG, ADFI, and gain:feed among treatments in different weeks. The overall (0 to 3 weeks) ADFI decreased in antibiotic treatment (pduck production.

  16. Tangles of type $E_n$ and a reducibility criterion for the Cohen-Wales representation of the Artin group of type $E_6$

    CERN Document Server

    Levaillant, Claire I

    2011-01-01

    We introduce tangles of type $E_n$ and construct a representation of the Birman-Murakami-Wenzl algebra (BMW algebra) of type $E_6$. As a representation of the Artin group of type $E_6$, this representation is equivalent to the faithful Cohen-Wales representation of type $E_6$ that was used to show the linearity of the Artin group of type $E_6$. We find a reducibility criterion for this representation and complex values of the parameters for which the algebra is not semisimple.

  17. Tangled in entanglements

    CERN Document Server

    Annila, Arto

    2010-01-01

    Two well-known conceptual conundrums of quantum mechanics referred to as instantaneous action-at-a-distance and inseparable wave-particle character are tackled using the principle of least action. Since any measurement is an action, it is reasoned that the spin of a particle just as the polarization of a photon remain indetermined for the observer until at least a quantum of action flows from the object to the observer. The detection places the quantity in question in the observer's frame of reference. This reference frame for one photon will instantaneously apply also to the polarization of the other photon provided that the two photons have not been perturbed ever since the correlated pair emerged from a radiative decay. The wave-particle duality of a single photon or an electron, that the double-slit experiment demonstrates, can also be understood in terms of actions. The energy density difference between the source of particles and their sink at the detector is a driving force that will cause flows of ene...

  18. A Tangled Web

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Syria’s ties to Russia and Iran make Western intervention unlikely After the fall of Muammar Gaddafi in Libya,Syria appeared to be the next target of Western powers.They have declared sanctions against Syria and publicly demanded Syrian President Bashar al-Assad step down.This Middle Eastern country now faces

  19. Identification of an amino-terminal fragment of apolipoprotein E4 that localizes to neurofibrillary tangles of the Alzheimer's disease brain.

    Science.gov (United States)

    Rohn, Troy T; Catlin, Lindsey W; Coonse, Kendra G; Habig, Jeffrey W

    2012-09-26

    Although the risk factor for harboring the apolipoprotein E4 (apoE4) allele in late-onset Alzheimer's disease (AD) is well known, the mechanism by which apoE4 contributes to AD pathogenesis has yet to be clarified. Preferential cleavage of the ApoE4 isoform relative to other polymorphic forms appears to be significant, as the resulting fragments are associated with hallmarks of AD. To examine the possible role of apoE4 proteolysis in AD, we designed a site-directed antibody directed at position D172, which would yield a predicted amino-terminal fragment previously identified in AD brain extracts. Western blot analysis utilizing this novel antibody, termed the amino-terminal apoE4 cleavage fragment (nApoE4CF) Ab, consistently identified the predicted amino-terminal fragment (∼18kDa) in several commercially available forms of human recombinant apoE4 purified from E. coli. Mass spectrometry confirmed the identity of this 18kDa fragment as being an amino-terminal fragment of apoE4. Immunohistochemical experiments indicated the nApoE4CF Ab specifically labeled neurofibrillary tangles (NFTs) in AD frontal cortex sections that colocalized with the mature tangle marker PHF-1. Taken together, these results suggest a novel cleavage event of apoE4, generating an amino-terminal fragment that localizes within NFTs of the AD brain.

  20. CANCER

    Directory of Open Access Journals (Sweden)

    N. Kavoussi

    1973-09-01

    Full Text Available There are many carcinogenetic elements in industry and it is for this reason that study and research concerning the effect of these materials is carried out on a national and international level. The establishment and growth of cancer are affected by different factors in two main areas:-1 The nature of the human or animal including sex, age, point and method of entry, fat metabolism, place of agglomeration of carcinogenetic material, amount of material absorbed by the body and the immunity of the body.2 The different nature of the carcinogenetic material e.g. physical, chemical quality, degree of solvency in fat and purity of impurity of the element. As the development of cancer is dependent upon so many factors, it is extremely difficult to determine whether a causative element is principle or contributory. Some materials are not carcinogenetic when they are pure but become so when they combine with other elements. All of this creates an industrial health problem in that it is almost impossible to plan an adequate prevention and safety program. The body through its system of immunity protects itself against small amounts of carcinogens but when this amount increases and reaches a certain level the body is not longer able to defend itself. ILO advises an effective protection campaign against cancer based on the Well –equipped laboratories, Well-educated personnel, the establishment of industrial hygiene within factories, the regular control of safety systems, and the implementation of industrial health principles and research programs.

  1. Effects of ozone treatment and gamma irradiation on the quality properties of dried-spirullina and dried-sea tangle powders

    International Nuclear Information System (INIS)

    For the purpose of improving hygienic quality of dried-spirullina and dried-sea tangle powders as raw materials of health food, the comparative effects of ozone treatment and gamma irradiation on the microbial and physicochemical properties were investigated. Gamma irradiation at 7.5 kGy resulted in sterilization of total aerobic bacteria, coliforms and molds below detective levels 101;CFU/g/;sample), while ozone treatment for 8 hr up to 18 ppm could not sufficiently eliminate the microorganisms of the samples. Physicochemical properties including compositions of fatty acid and amino acid, minerals, pH and natural pigments were not changed by gamma irradiation up to 10 kGy, whereas, ozone treatment caused changes in pH, TBA value, natural pigments and fatty acid compositions. Especially, ozone treatment markedly decreased unsaturated fatty acid of the samples

  2. Supplement to “Torsional Oscillations of a Magnetar with a Tangled Magnetic Field” (2016, ApJL, 823, L1)

    Science.gov (United States)

    Link, Bennett; van Eysden, C. Anthony

    2016-05-01

    We introduce a mean-field formalism with which to study the oscillations of a neutron star or other stellar object with a dipolar magnetic field plus a topologically distinct isotropic magnetic tangle that stabilizes the field configuration. In terms of the ratio of the energy density of the tangled field to that in the dipolar component b t 2, we obtain separable equations for the eigenfunctions and eigenfrequencies for a star of uniform density. We show that finite b t 2 breaks the Alfvén continuum that is supported by the dipolar component of the field into discrete normal modes, and we quantify the splitting. Assuming the estimated dipole fields of 7× {10}14 G in SGR 1900+14 and 2× {10}15 G in SGR 1806-20, and tuning b t 2 to match the lowest-frequency quasi-periodic oscillations observed to accompany flares in these objects, we infer {b}t2=13.3 and 0.17, respectively. The predicted spectrum is about three times denser than that observed in SGR 1900+14, and much denser in SGR 1806-20. If the dipole field of SGR 1806-20 has been overestimated, the spectrum of normal modes will be less dense. We show that for {b}t2\\gg 1, as stability considerations suggest, the crust is nearly dynamically irrelevant. Moreover, density stratification generally shifts the eigenfrequencies up by about 20%, a change that can be mostly subsumed in a uniform density model with a slightly different choice of stellar radius or mass. This Supplement provides additional material to Link & van Eysden (2016).

  3. Analysis on Reasons of Outpatient and Emergency Department Nursing Tangle in Grass-roots Hospital%基层医院门急诊科护理纠纷的原因分析

    Institute of Scientific and Technical Information of China (English)

    张宇燕; 冯科壬

    2011-01-01

    分析引起护理纠纷的各种隐患因素,通过制定加强护士队伍建设,合理配置护理人力资源,对护理人员进行相关培训,进行相关法律、法规知识教育,减轻护士心理压力以及加强护患沟通等一系列管理措施,达到有效地促进护理安全,防范护理纠纷,全面提高护理质量的目的 .%An analysis on different hidden trouble factors leading to nursing tangle, through nursing construction strengthening, nursing human resources rational allocation, related law and regulations knowledge training, nurses psychological pressure lightening and nurse- patient communication, it achieves nursing safety improvement effective, nursing tangle prevention and nursing quality improvement comprehensive.

  4. Diversity, distribution and floral specificity of tangle-veined flies (Diptera: Nemestrinidae) in north west Patagonia, Argentina Diversidad, distribución y especificidad floral de nemestrínidos (Diptera) en el noroeste de la Patagonia, Argentina

    OpenAIRE

    MARIANO DEVOTO; DIEGO MEDAN

    2006-01-01

    Tangle-veined flies (Nemestrinidae) constitute a primitive and rather widespread family among Diptera. The genus Trichophthalma occurs in Australia and South America and is the only one in the family with a typically Gondwanian, disjoint distribution. The ecology and distribution of most southern South American species of this genus remains virtually unknown. We studied the diversity, distribution and flower specificity of flower-visiting species of the genus Trichophthalma in the temperate f...

  5. Cancer Basics

    Science.gov (United States)

    ... Cancer? Breast Cancer Colon/Rectum Cancer Lung Cancer Prostate Cancer Skin Cancer Show All Cancer Types News and Features Cancer Glossary ACS Bookstore Cancer Information Cancer Basics Cancer Prevention & Detection Signs & Symptoms of Cancer Treatments & Side Effects ...

  6. Composite drying with simultaneous vacuum and toggling

    Science.gov (United States)

    Drying is one of key steps to govern the physical properties of leather and it is where leather acquires its final texture, consistency and flexibility. Recently we have been working diligently to improve chrome-free leather by optimizing its drying process. We developed a drying method using a co...

  7. On Influential Factors of Medical Tangles in the Third Grade A-level Hospitals in Some City%某市三甲医院医疗纠纷影响因素的研究

    Institute of Scientific and Technical Information of China (English)

    王志刚; 孟祥志

    2015-01-01

    Objective:To investigate cases of medical tangle in resent years in the Third grade A‐level hos‐pitals in some city and analyze the factors affacting the occurance of medical tangles .Methods:Analyze 211 re‐cords of medical tangle happened in three Third grade A‐level hospitals in some city during the period from January 2011 to December 2013 retrospectively ,take the cases which ,based on 1∶2 ,were involved the con‐current same kind of cases in charged by different doctors from the same section as the control group .Collect the basic data ,the data of patient party and the data of the medical party .Make single factor analysis and multiple factor analysis on the factors which may affect the occurance of medical tangle with χ2 test and logis‐tic regression model .Results:The single factor analysis revealed that medical costs ,education degree ,jobs , types of medical insurance of the patient partys ,medical service attitude and actions of the medical staff were the factors w hich resulted in the medical tangles ;multiple factor analysis of logistic regression hinted that medical service attitude and actions of the medical staff were the independent factors which resulted in the medical tangles .Conclusion:Medical service attitude and actions of the medical staff are the independent fac‐tors w hich result in the medical tangles and they are also the protective factors .%目的:调查某市三甲医院近年发生的医疗纠纷案例,分析影响医疗纠纷发生的因素。方法:回顾性分析2011年1月~2013年12月某市三所三甲医院发生医疗纠纷的档案211份,按1∶2纳入同期同科室不同医生管床的同种病例作为对照组。采集病例的基本信息、患方信息、医方信息,应用χ2检验及 Logical回归模型对可能影响医疗纠纷发生的因素进行单因素和多因素分析。结果:单因素分析结果显示,医疗费用、患方文化程度、职业和医保类别、医务人员

  8. Enhanced neurofibrillary tangle formation, cerebral atrophy, and cognitive deficits induced by repetitive mild brain injury in a transgenic tauopathy mouse model.

    Science.gov (United States)

    Yoshiyama, Yasumasa; Uryu, Kunihiro; Higuchi, Makoto; Longhi, Luca; Hoover, Rachel; Fujimoto, Scott; McIntosh, Tracy; Lee, Virginia M-Y; Trojanowski, John Q

    2005-10-01

    Traumatic brain injury (TBI) is a risk factors for Alzheimer's disease (AD), and repetitive TBI (rTBI) may culminate in dementia pugilistica (DP), a syndrome characterized by progressive dementia, parkinsonism, and the hallmark brain lesions of AD, including neurofibrillary tangles (NFTs), formed by abnormal tau filaments and senile plaques (SPs) composed of Abeta fibrils. Previous study showed that mild rTBI (mrTBI) accelerated the deposition of Abeta in the brains of transgenic (Tg) mice (Tg2576) that over-express human Abeta precursor proteins with the familial AD Swedish mutations (APP695swe) and model of AD-like amyloidosis. Here, we report studies of the effects of mrTBI on AD-like tau pathologies in Tg mice expressing the shortest human tau isoform (T44) subjected to mrTBI, causing brain concussion without structural brain damage to simulate injuries linked to DP. Twelve-month-old Tg T44 (n = 18) and wild-type (WT; n = 24) mice were subjected to mrTBI (four times a day, 1 day per week, for 4 weeks; n = 24) or sham treatment (n = 18). Histopathological analysis of mice at 9 months after mrTBI revealed that one of the Tg T44 mice showed extensive telencephalic NFT and cerebral atrophy. Although statistical analysis of neurobehavioral tests at 6 months after mrTBI did not show any significant difference in any of groups of mice, the Tg T44 mouse with extensive NFT had an exceptionally low neurobehavioral score. The reasons for the augmentation of tau pathologies in only one T44 tau Tg mouse subjected to mrTBI remain to be elucidated.

  9. 基于同步齿形带与滚动螺旋-铰杆增力机构的伺服压力机设计%Design of Servo Press Based on the Synchronous Belt and Scroll Spiral-toggle Force Amplifier

    Institute of Scientific and Technical Information of China (English)

    夏春风; 钟康民; 杨丽琴

    2012-01-01

    设计一种基于同步齿形带与滚动螺旋-铰杆增力机构伺服压力机,分析其工作原理,给出压力机的压力计算公式.该压力机利用伺服电机产生动力,动力经同步齿形带放大后再传给滚珠丝杆,经左右旋滚珠丝杆带动套筒上的浮动滚子和铰杆增力机构运动,产生向下的压力,实现对工件加压.该压力机结构紧凑,运动精确,功能较为完善,可远距离传动,传动效率高,噪声小.其能在高温、腐蚀等恶劣环境下工作,不需要润滑,且节能,无污染,绿色化特征明显.%A new kind of servo press based on the synchronous belt and scroll spiral-toggle force amplifier was designed. The working principle of press was introduced, and the relevant pressure formula of the press was presented. The power was generated by servo motor, enlarged by the synchronous belt and transmitted to the ball screw. The left or right ball screw makes both the floating rollers on the sleeves and the toggle force mechanism to move, which would exert a downward pressure to the work piece. The press is characterized by its compactness, precise movement, perfect performance, long distance transmission, high efficiency and low noise. It can also work in the hard environment of high temperature and corrosion without lubrication. At the same time, it is energy-efficient and pollution-free. So, the charaer of green product is evident too.

  10. The Tangle of Student Allowances.

    Science.gov (United States)

    Thomson, Norman J.

    1980-01-01

    A discussion of the distribution of student financial aid in Australia focuses on these issues: direct vs. indirect payment to students; inequality in living allowances given to secondary and postsecondary students; and distribution of expense allowances by state government and living allowances by the Commonwealth. (MSE)

  11. Effect of ultramafic intrusions and associated mineralized rocks on the aqueous geochemistry of the Tangle Lakes Area, Alaska: Chapter C in Studies by the U.S. Geological Survey in Alaska, 2011

    Science.gov (United States)

    Wang, Bronwen; Gough, Larry P.; Wanty, Richard B.; Lee, Gregory K.; Vohden, James; O’Neill, J. Michael; Kerin, L. Jack

    2013-01-01

    Stream water was collected at 30 sites within the Tangle Lakes area of the Delta mineral belt in Alaska. Sampling focused on streams near the ultramafic rocks of the Fish Lake intrusive complex south of Eureka Creek and the Tangle Complex area east of Fourteen Mile Lake, as well as on those within the deformed metasedimentary, metavolcanic, and intrusive rocks of the Specimen Creek drainage and drainages east of Eureka Glacier. Major, minor, and trace elements were analyzed in aqueous samples for this reconnaissance aqueous geochemistry effort. The lithologic differences within the study area are reflected in the major-ion chemistry of the water. The dominant major cation in streams draining mafic and ultramafic rocks is Mg2+; abundant Mg and low Ca in these streams reflect the abundance of Mg-rich minerals in these intrusions. Nickel and Cu are detected in 84 percent and 87 percent of the filtered samples, respectively. Nickel and Cu concentrations ranged from Ni profiles for the aqueous samples were light rare earth element depleted, with negative Ce and Eu anomalies, indicating fractionation of the REE during weathering. Fractionation patterns indicate that the REE are primarily in the dissolved, as opposed to colloidal, phase.

  12. On the relationship between the mediation and prevent of medical tangle and the construction of harmonious society%医患纠纷调节和防范机制探讨

    Institute of Scientific and Technical Information of China (English)

    宿文军

    2012-01-01

    目的 探讨构建和谐社会与医患纠纷调节和防范机制的关系.方法 通过分析目前我国医患纠纷的现状,探讨其调节和防范机制与构建和谐社会的关系.结果 在调查处理方面,首先要查明事实,对涉及死亡的医疗纠纷案例要尽早做尸体解剖,以查明死因、分清责任;其次是根据事实,依法调查处理;同时要做好说服解释工作,力求和谐.在防范方面,健全的法制、完善的规章制度是减少和调查处理好医疗纠纷的重要保证,医、患双方良好的道德和文化素质是避免发生医疗纠纷并易调查处理的重要因素;加强医院的科学管理是防范医疗事故的关键,增强医护人员的工作责任心提高专业技术水平和服务质量是防范医疗事故的根本.结论 目前,我国的医疗纠纷不断增多、调处难度增大,已引起医药卫生、司法系统、行政部门以及社会上的广泛关注.因此,及时有效地调解处理好各种医疗纠纷,并最大限度地防范医疗纠纷的发生,是解决医疗纠纷这一特殊矛盾,维护安定团结,构建和谐社会的一个十分重要的内容.%Objective Analysis of constructing harmonious society and medical dispute adjustment and the relation to guard. Methods Through analyzing the current doctor-patient dispute in China the status quo of their regulation and prevention and harmonious society . Results At the aspect of mediation of medical tangle; Firstly, it is necessary to make the fact clear. Autopsy must be done as soon as possible if the patient died in order to ascertain the cause of death and distinguish the fact and correspondence responsibility. Next, it must be mediated legally according to the fact, and at the same time, the work of persuasion and explanation should be done well so as to strive to be harmony among them. About the prevention of medical tangle; The perfect legal system and the complete rules and regulations are the important guarantee

  13. Cancer Statistics: Endometrial Cancer

    Science.gov (United States)

    ... a third party. HPF: Did You Know? Endometrial Cancer Endometrial Cancer - Did you know that endometrial cancer ... mfhs0vbvWi8?rel=0 SEER Stat Fact Sheets: Endometrial Cancer Expand All Collapse All Lifetime risk estimates are ...

  14. γ-Aminobutyric Acid (GABA) Production and Angiotensin-I Converting Enzyme (ACE) Inhibitory Activity of Fermented Soybean Containing Sea Tangle by the Co-Culture of Lactobacillus brevis with Aspergillus oryzae.

    Science.gov (United States)

    Jang, Eun Kyeong; Kim, Nam Yeun; Ahn, Hyung Jin; Ji, Geun Eog

    2015-08-01

    To enhance the γ-aminobutyric acid (GABA) content, the optimized fermentation of soybean with added sea tangle extract was evaluated at 30°C and pH 5.0. The medium was first inoculated with Aspergillus oryzae strain FMB S46471 and fermented for 3 days, followed by the subsequent inoculation with Lactobacillus brevis GABA 100. After fermentation for 7 days, the fermented soybean showed approximately 1.9 g/kg GABA and exhibited higher ACE inhibitory activity than the traditional soybean product. Furthermore, several peptides in the fraction containing the highest ACE inhibitory activity were identified. The novel fermented soybean enriched with GABA and ACE inhibitory components has great pharmaceutical and functional food values.

  15. Cancer - resources

    Science.gov (United States)

    Resources - cancer ... The following organizations are good resources for information on cancer : American Cancer Society -- www.cancer.org Cancer Care -- www.cancercare.org National Cancer Institute -- www.cancer.gov

  16. Cancer Statistics

    Science.gov (United States)

    ... What Is Cancer? Cancer Statistics Cancer Disparities Cancer Statistics Cancer has a major impact on society in ... success of efforts to control and manage cancer. Statistics at a Glance: The Burden of Cancer in ...

  17. 6 Common Cancers - Prostate Cancer

    Science.gov (United States)

    ... PSA tests. Read More "6 Common Cancers" Articles Lung Cancer / Breast Cancer / Prostate Cancer / Colorectal Cancer / Skin Cancer / Gynecologic Cancers Spring 2007 Issue: Volume 2 Number 2 Page 10 MedlinePlus | Subscribe | Magazine Information | Contact Us | Viewers & ...

  18. 6 Common Cancers - Colorectal Cancer

    Science.gov (United States)

    ... certain people. Read More "6 Common Cancers" Articles Lung Cancer / Breast Cancer / Prostate Cancer / Colorectal Cancer / Skin Cancer / Gynecologic Cancers Spring 2007 Issue: Volume 2 Number 2 Page 11 MedlinePlus | Subscribe | Magazine Information | Contact Us | Viewers & ...

  19. Vulva cancer

    Science.gov (United States)

    Cancer - vulva; Cancer - perineum; Cancer - vulvar; Genital warts - vulvar cancer; HPV - vulvar cancer ... cells. Other types of cancers found on the vulva are: Adenocarcinoma Basal cell carcinoma Melanoma Sarcoma Vulvar ...

  20. Colon cancer

    Science.gov (United States)

    Colorectal cancer; Cancer - colon; Rectal cancer; Cancer - rectum; Adenocarcinoma - colon; Colon - adenocarcinoma ... In the United States, colorectal cancer is one of the leading causes of deaths due to cancer. Early diagnosis can often lead to a complete cure. Almost ...

  1. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Renal Cell) Cancer Leukemia Lung Cancer Lymphoma Pancreatic Cancer Prostate Cancer Skin Cancer Thyroid Cancer Uterine Cancer All ... Cancer Biology Cancer Genomics Causes of Cancer Diagnosis Prevention Screening & Early Detection Treatment Cancer & Public Health Cancer ...

  2. Tobacco and Cancer

    Science.gov (United States)

    ... Cancer? Breast Cancer Colon/Rectum Cancer Lung Cancer Prostate Cancer Skin Cancer Show All Cancer Types News and Features Cancer Glossary ACS Bookstore Cancer Information Cancer Basics Cancer Prevention & Detection Signs & Symptoms of Cancer Treatments & Side Effects ...

  3. Stages of Prostate Cancer

    Science.gov (United States)

    ... Renal Cell) Cancer Leukemia Lung Cancer Lymphoma Pancreatic Cancer Prostate Cancer Skin Cancer Thyroid Cancer Uterine Cancer All ... Cancer Treatment Prostate Cancer Prevention Genetics of Prostate Cancer Prostate Cancer Screening Research Prostate Cancer Treatment (PDQ®)–Patient ...

  4. Effect of ultramafic intrusions and associated mineralized rocks on the aqueous geochemistry of the Tangle Lakes Area, Alaska: Chapter C in Studies by the U.S. Geological Survey in Alaska, 2011

    Science.gov (United States)

    Wang, Bronwen; Gough, Larry P.; Wanty, Richard B.; Lee, Gregory K.; Vohden, James; O’Neill, J. Michael; Kerin, L. Jack

    2013-01-01

    Stream water was collected at 30 sites within the Tangle Lakes area of the Delta mineral belt in Alaska. Sampling focused on streams near the ultramafic rocks of the Fish Lake intrusive complex south of Eureka Creek and the Tangle Complex area east of Fourteen Mile Lake, as well as on those within the deformed metasedimentary, metavolcanic, and intrusive rocks of the Specimen Creek drainage and drainages east of Eureka Glacier. Major, minor, and trace elements were analyzed in aqueous samples for this reconnaissance aqueous geochemistry effort. The lithologic differences within the study area are reflected in the major-ion chemistry of the water. The dominant major cation in streams draining mafic and ultramafic rocks is Mg2+; abundant Mg and low Ca in these streams reflect the abundance of Mg-rich minerals in these intrusions. Nickel and Cu are detected in 84 percent and 87 percent of the filtered samples, respectively. Nickel and Cu concentrations ranged from Ni <0.4 to 10.1 micrograms per liter (mg/L), with a median of 4.2 mg/L, and Cu <0.5 to 27 mg/L, with a median of 1.2 mg/L. Trace-element concentrations in water are generally low relative to U.S. Environmental Protection Agency freshwater aquatic-life criteria; however, Cu concentrations exceed the hardness-based criteria for both chronic and acute exposure at some sites. The entire rare earth element (REE) suite is found in samples from the Specimen Creek sites MH5, MH4, and MH6 and, with the exception of Tb and Tm, at site MH14. These samples were all collected within drainages containing or downstream from Tertiary gabbro, diabase, and metagabbro (Trgb) exposures. Chondrite and source rock fractionation profiles for the aqueous samples were light rare earth element depleted, with negative Ce and Eu anomalies, indicating fractionation of the REE during weathering. Fractionation patterns indicate that the REE are primarily in the dissolved, as opposed to colloidal, phase.

  5. Diversity, distribution and floral specificity of tangle-veined flies (Diptera: Nemestrinidae in north west Patagonia, Argentina Diversidad, distribución y especificidad floral de nemestrínidos (Diptera en el noroeste de la Patagonia, Argentina

    Directory of Open Access Journals (Sweden)

    MARIANO DEVOTO

    2006-03-01

    Full Text Available Tangle-veined flies (Nemestrinidae constitute a primitive and rather widespread family among Diptera. The genus Trichophthalma occurs in Australia and South America and is the only one in the family with a typically Gondwanian, disjoint distribution. The ecology and distribution of most southern South American species of this genus remains virtually unknown. We studied the diversity, distribution and flower specificity of flower-visiting species of the genus Trichophthalma in the temperate forests of southern South America in ten sites along an east-west rainfall gradient (37-40°S on the eastern slope of the Andes. We recorded nine species of Trichophthalma, which showed an overlapped distribution along the gradient and different degrees of floral specificity. Three species are reported for Argentina for the first time and three are first recorded as flower visitors to the local flora. Our results show that while in southern Africa tangle-veined flies are engaged in highly specialized pollination interactions with long-tubed species, the Trichophthalma spp. of Patagonia share their flowers with a diverse and rather unspecialized visitor fauna among which several species of flies, bees and birds are presentLos nemestrínidos constituyen una familia de Dípteros primitiva y de amplia distribución. El género Trichophthalma se encuentra en Australia y Sudamérica y es el único en la familia con una distribución disjunta típicamente gondwánica. La ecología y distribución de la mayoría de las especies sudamericanas permanecen virtualmente desconocidas. Estudiamos la diversidad, distribución y especificidad floral de las especies del género Trichophthalma de los bosques templados del sur de Sudamérica en diez sitios ubicados a lo largo de un gradiente de precipitación este-oeste (37-40°S sobre la vertiente occidental de los Andes. Registramos nueve especies de Trichophthalma, las cuales mostraron una distribución superpuesta a lo largo

  6. An inconspicuous, conspicuous new species of Asian pipesnake, genus Cylindrophis (Reptilia: Squamata: Cylindrophiidae), from the south coast of Jawa Tengah, Java, Indonesia, and an overview of the tangled taxonomic history of C. ruffus (Laurenti, 1768).

    Science.gov (United States)

    Kieckbusch, Max; Mecke, Sven; Hartmann, Lukas; Ehrmantraut, Lisa; O'shea, Mark; Kaiser, Hinrich

    2016-03-20

    We describe a new species of Cylindrophis currently known only from Grabag, Purworejo Regency, Jawa Tengah Pro-vince (Central Java), Java, Indonesia. Cylindrophis subocularis sp. nov. can be distinguished from all congeners by the presence of a single, eponymous subocular scale between the 3rd and 4th or 4th and 5th supralabial, preventing contact between the 4th or 5th supralabial and the orbit, and by having the prefrontal in narrow contact with or separated from the orbit. We preface our description with a detailed account of the tangled taxonomic history of the similar and putatively wide-ranging species C. ruffus, which leads us to (1) remove the name Scytale scheuchzeri from the synonymy of C. ruffus, (2) list the taxon C. rufa var. javanica as species inquirenda, and (3) synonymize C. mirzae with C. ruffus. We provide additional evidence to confirm that the type locality of C. ruffus is Java. Cylindrophis subocularis sp. nov. is the second species of Asian pipesnake from Java.

  7. Oral Cancer

    Science.gov (United States)

    ... TMJ Disorders Oral Cancer Dry Mouth Burning Mouth Tooth Decay See All Oral Complications of Systemic Diseases Cancer ... Puts Someone at Risk? Possible Signs & Symptoms Early Detection About Oral Cancer Oral cancer includes cancers of ...

  8. 6 Common Cancers - Breast Cancer

    Science.gov (United States)

    ... Home Current Issue Past Issues 6 Common Cancers - Breast Cancer Past Issues / Spring 2007 Table of Contents For ... slow her down. Photo: AP Photo/Brett Flashnick Breast Cancer Breast cancer is a malignant (cancerous) growth that ...

  9. Identification of novel targets for breast cancer by exploring gene switches on a genome scale

    Directory of Open Access Journals (Sweden)

    Wu Ming

    2011-11-01

    Full Text Available Abstract Background An important feature that emerges from analyzing gene regulatory networks is the "switch-like behavior" or "bistability", a dynamic feature of a particular gene to preferentially toggle between two steady-states. The state of gene switches plays pivotal roles in cell fate decision, but identifying switches has been difficult. Therefore a challenge confronting the field is to be able to systematically identify gene switches. Results We propose a top-down mining approach to exploring gene switches on a genome-scale level. Theoretical analysis, proof-of-concept examples, and experimental studies demonstrate the ability of our mining approach to identify bistable genes by sampling across a variety of different conditions. Applying the approach to human breast cancer data identified genes that show bimodality within the cancer samples, such as estrogen receptor (ER and ERBB2, as well as genes that show bimodality between cancer and non-cancer samples, where tumor-associated calcium signal transducer 2 (TACSTD2 is uncovered. We further suggest a likely transcription factor that regulates TACSTD2. Conclusions Our mining approach demonstrates that one can capitalize on genome-wide expression profiling to capture dynamic properties of a complex network. To the best of our knowledge, this is the first attempt in applying mining approaches to explore gene switches on a genome-scale, and the identification of TACSTD2 demonstrates that single cell-level bistability can be predicted from microarray data. Experimental confirmation of the computational results suggest TACSTD2 could be a potential biomarker and attractive candidate for drug therapy against both ER+ and ER- subtypes of breast cancer, including the triple negative subtype.

  10. Cancer Statistics: Pancreas Cancer

    Science.gov (United States)

    ... qnad9A-rfcw?rel=0 SEER Stat Fact Sheets: Pancreas Cancer Expand All Collapse All Statistics at a ... 5 Years Or More after Being Diagnosed with Pancreas Cancer? Relative survival statistics compare the survival of ...

  11. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Types Recurrent Cancer Common Cancer Types Bladder Cancer Breast Cancer Colorectal Cancer Kidney (Renal Cell) Cancer Leukemia Lung ... Biology Cancer Genomics Causes of Cancer Diagnosis Prevention Screening & Early Detection Treatment Cancer & Public Health Cancer Health ...

  12. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Treatment Pediatric Supportive Care Unusual Cancers of Childhood Treatment Research Metastatic Cancer Metastatic Cancer Research Common Cancer Types Recurrent Cancer Common Cancer Types Bladder Cancer Breast Cancer Colorectal Cancer Kidney (Renal Cell) Cancer Leukemia ...

  13. 6 Common Cancers - Lung Cancer

    Science.gov (United States)

    ... Home Current Issue Past Issues 6 Common Cancers - Lung Cancer Past Issues / Spring 2007 Table of Contents For ... for Desperate Housewives. (Photo ©2005 Kathy Hutchins / Hutchins) Lung Cancer Lung cancer causes more deaths than the next ...

  14. 6 Common Cancers - Skin Cancer

    Science.gov (United States)

    ... Home Current Issue Past Issues 6 Common Cancers - Skin Cancer Past Issues / Spring 2007 Table of Contents For ... Photo: AP Photo/Herald-Mail, Kevin G. Gilbert Skin Cancer Skin cancer is the most common form of ...

  15. Biological Signal Processing with a Genetic Toggle Switch

    OpenAIRE

    Patrick Hillenbrand; Georg Fritz; Ulrich Gerland

    2013-01-01

    Complex gene regulation requires responses that depend not only on the current levels of input signals but also on signals received in the past. In digital electronics, logic circuits with this property are referred to as sequential logic, in contrast to the simpler combinatorial logic without such internal memory. In molecular biology, memory is implemented in various forms such as biochemical modification of proteins or multistable gene circuits, but the design of the regulatory interface, ...

  16. Biological Signal Processing with a Genetic Toggle Switch

    Science.gov (United States)

    Hillenbrand, Patrick; Fritz, Georg; Gerland, Ulrich

    2013-01-01

    Complex gene regulation requires responses that depend not only on the current levels of input signals but also on signals received in the past. In digital electronics, logic circuits with this property are referred to as sequential logic, in contrast to the simpler combinatorial logic without such internal memory. In molecular biology, memory is implemented in various forms such as biochemical modification of proteins or multistable gene circuits, but the design of the regulatory interface, which processes the input signals and the memory content, is often not well understood. Here, we explore design constraints for such regulatory interfaces using coarse-grained nonlinear models and stochastic simulations of detailed biochemical reaction networks. We test different designs for biological analogs of the most versatile memory element in digital electronics, the JK-latch. Our analysis shows that simple protein-protein interactions and protein-DNA binding are sufficient, in principle, to implement genetic circuits with the capabilities of a JK-latch. However, it also exposes fundamental limitations to its reliability, due to the fact that biological signal processing is asynchronous, in contrast to most digital electronics systems that feature a central clock to orchestrate the timing of all operations. We describe a seemingly natural way to improve the reliability by invoking the master-slave concept from digital electronics design. This concept could be useful to interpret the design of natural regulatory circuits, and for the design of synthetic biological systems. PMID:23874595

  17. Stochastic analysis of a miRNA-protein toggle switch

    CERN Document Server

    Giampieri, E; de Oliveira, L; Castellani, G; Lió, P

    2011-01-01

    Within systems biology there is an increasing interest in the stochastic behavior of genetic and biochemical reaction networks. An appropriate stochastic description is provided by the chemical master equation, which represents a continuous time Markov chain (CTMC). In this paper we consider the stochastic properties of a biochemical circuit, known to control eukaryotic cell cycle and possibly involved in oncogenesis, recently proposed in the literature within a deterministic framework. Due to the inherent stochasticity of biochemical processes and the small number of molecules involved, the stochastic approach should be more correct in describing the real system: we study the agreement between the two approaches by exploring the system parameter space. We address the problem by proposing a simplified version of the model that allows analytical treatment, and by performing numerical simulations for the full model. We observed optimal agreement between the stochastic and the deterministic description of the ci...

  18. Unraveling the Tangles of Language Evolution

    Science.gov (United States)

    Petroni, F.; Serva, M.; Volchenkov, D.

    2012-07-01

    The relationships between languages molded by extremely complex social, cultural and political factors are assessed by an automated method, in which the distance between languages is estimated by the average normalized Levenshtein distance between words from the list of 200 meanings maximally resistant to change. A sequential process of language classification described by random walks on the matrix of lexical distances allows to represent complex relationships between languages geometrically, in terms of distances and angles. We have tested the method on a sample of 50 Indo-European and 50 Austronesian languages. The geometric representations of language taxonomy allows for making accurate interfaces on the most significant events of human history by tracing changes in language families through time. The Anatolian and Kurgan hypothesis of the Indo-European origin and the "express train" model of the Polynesian origin are thoroughly discussed.

  19. Tangled in a sparse spider web

    DEFF Research Database (Denmark)

    Dimitrov, Dimitar Stefanov; Lopardo, Lara; Giribet, Gonzalo;

    2012-01-01

    In order to study the tempo and the mode of spider orb web evolution and diversification, we conducted a phylogenetic analysis using six genetic markers along with a comprehensive taxon sample. The present analyses are the first to recover the monophyly of orb-weaving spiders based solely on DNA...... orb-weaving families and web designs were already present. The processes that may have given origin to this diversification of lineages and web architectures are discussed. A combination of biotic factors, such as key innovations in web design and silk composition, as well as abiotic environmental...

  20. Asthma and cystic fibrosis: A tangled web.

    LENUS (Irish Health Repository)

    Kent, Brian D

    2014-03-01

    Successfully diagnosing concomitant asthma in people with cystic fibrosis (CF) is a challenging proposition, and the utility of conventional diagnostic criteria of asthma in CF populations remains uncertain. Nonetheless, the accurate identification of individuals with CF and asthma allows appropriate tailoring of therapy, and should reduce the unnecessary use of asthma medication in broader CF cohorts. In this review, we discuss the diagnostic challenge posed by asthma in CF, both in terms of clinical evaluation, and of interpretation of pulmonary function testing and non-invasive markers of airway inflammation. We also examine how the role of cross-sectional thoracic imaging in CF and asthma can assist in the diagnosis of asthma in these patients. Finally, we critically appraise the evidence base behind the use of asthma medications in CF populations, with a particular focus on the use of inhaled corticosteroids and bronchodilators. As shall be discussed, the gaps in the current literature make further high-quality research in this field imperative. Pediatr Pulmonol. 2014; 49:205-213. © 2014 Wiley Periodicals, Inc.

  1. Mate Choice: Charting Desire's Tangled Bank.

    Science.gov (United States)

    Rosenthal, Gil G

    2016-04-01

    Choosing a mate requires a way to turn sexual arousal into sexual action. A recent paper identifies a hormone receptor that acts as a molecular gatekeeper in reproductive decisions. Focusing on mate-choice mechanisms may clarify longstanding evolutionary puzzles in sexual selection and speciation. PMID:27046819

  2. The Magnificent Tangle That is Education.

    Science.gov (United States)

    Rost, H. T. D.

    1979-01-01

    In view of the call by reformers and critics for a new definition of education itself, the author investigates some of the difficulties in formulating such a definition by utilizing the study of language as well as linguistics, semantics, and etymology. (Author/SJL)

  3. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Services Advance Directives Using Trusted Resources Cancer Types Adolescents and Young Adults with Cancer Reports, Research, and ... of Cancers Cancers by Body Location Childhood Cancers Adolescent & Young Adult Cancers Metastatic Cancer Recurrent Cancer Research ...

  4. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Contact Dictionary Search About Cancer Causes and Prevention Risk Factors Genetics Cancer Prevention Overview Cancer Prevention Overview–for ... Cancer What Is Cancer Cancer Statistics Causes & Prevention Risk Factors Genetics Cancer Prevention Overview Screening Cancer Screening Overview ...

  5. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Contact Dictionary Search About Cancer Causes and Prevention Risk Factors Genetics Cancer Prevention Overview Cancer Prevention Overview– ... Is Cancer Cancer Statistics Cancer Disparities Causes & Prevention Risk Factors Genetics Cancer Prevention Overview Screening Cancer Screening ...

  6. Lung Cancer

    Science.gov (United States)

    Lung cancer is one of the most common cancers in the world. It is a leading cause of ... in the United States. Cigarette smoking causes most lung cancers. The more cigarettes you smoke per day and ...

  7. Bone Cancer

    Science.gov (United States)

    ... cancer. Surgery is often the main treatment for bone cancer. Other treatments may include amputation, chemotherapy, and radiation therapy. Because bone cancer can come back after treatment, regular follow-up visits are important. NIH: National ...

  8. Testicular cancer

    Science.gov (United States)

    Testicular cancer is cancer that starts in the testicles, the male reproductive glands located in the scrotum. ... developing testicular cancer increases if he has: Abnormal testicle development Exposure to certain chemicals Family history of ...

  9. Thyroid Cancer

    Science.gov (United States)

    ... body work normally. There are several types of cancer of the thyroid gland. You are at greater ... imaging tests, and a biopsy to diagnose thyroid cancer. Treatment depends on the type of cancer you ...

  10. Cancer Moonshot

    Science.gov (United States)

    The Cancer Moonshot, led by Vice President Joe Biden, will marshal resources across the federal government to speed progress in cancer research and lead to improved cancer prevention, detection, and treatment.

  11. Uterine Cancer

    Science.gov (United States)

    ... is pregnant. There are different types of uterine cancer. The most common type starts in the endometrium, the lining of the uterus. This type of cancer is sometimes called endometrial cancer. The symptoms of ...

  12. Stomach Cancer

    Science.gov (United States)

    ... with stomach acid and helps digest protein. Stomach cancer mostly affects older people - two-thirds of people ... Smoke cigarettes Have a family history of stomach cancer It is hard to diagnose stomach cancer in ...

  13. Skin Cancer

    Science.gov (United States)

    Skin cancer is the most common form of cancer in the United States. The two most common types ... face, neck, hands, and arms. Another type of skin cancer, melanoma, is more dangerous but less common. Anyone ...

  14. Integrated Molecular Profiling in Advanced Cancers Trial

    Science.gov (United States)

    2016-06-21

    Breast Cancer; Non-small Cell Lung Cancer; Colorectal Cancer; Genitourinary Cancer; Pancreatobiliary Gastrointestinal Cancer; Upper Aerodigestive Tract Cancer; Gynecological Cancers; Melanoma Cancers; Rare Cancers; Unknown Primary Cancers

  15. Cancer Research Repository for Individuals With Cancer Diagnosis and High Risk Individuals.

    Science.gov (United States)

    2014-12-12

    Pancreatic Cancer; Thyroid Cancer; Lung Cancer; Esophageal Cancer; Thymus Cancer; Colon Cancer; Rectal Cancer; GIST; Anal Cancer; Bile Duct Cancer; Duodenal Cancer; Gallbladder Cancer; Gastric Cancer; Liver Cancer; Small Intestine Cancer; Peritoneal Surface Malignancies; Familial Adenomatous Polyposis; Lynch Syndrome; Bladder Cancer; Kidney Cancer; Penile Cancer; Prostate Cancer; Testicular Cancer; Ureter Cancer; Urethral Cancer; Hypopharyngeal Cancer; Laryngeal Cancer; Lip Cancer; Oral Cavity Cancer; Nasopharyngeal Cancer; Oropharyngeal Cancer; Paranasal Sinus Cancer; Nasal Cavity Cancer; Salivary Gland Cancer; Skin Cancer; CNS Tumor; CNS Cancer; Mesothelioma

  16. Vaginal Cancer

    Science.gov (United States)

    Vaginal cancer is a rare type of cancer. It is more common in women 60 and older. You are also more likely to get it if you have had a human ... test can find abnormal cells that may be cancer. Vaginal cancer can often be cured in its ...

  17. Lung Cancer

    Science.gov (United States)

    Lung cancer is one of the most common cancers in the world. It is a leading cause of cancer death in men and women in the United States. Cigarette smoking causes most lung cancers. The more cigarettes you smoke per day and ...

  18. Childhood Cancer

    Science.gov (United States)

    ... Story" 5 Things to Know About Zika & Pregnancy Childhood Cancer KidsHealth > For Parents > Childhood Cancer Print A A A Text Size What's ... in children, but can happen. The most common childhood cancers are leukemia , lymphoma , and brain cancer . As ...

  19. Lung Cancer

    Science.gov (United States)

    ... spreads in different ways, and each is treated differently. Non-small cell lung cancer is more common than small cell lung cancer. Small cell lung cancer grows more quickly and is more likely to spread to other organs in the body. Learn more about non-small cell lung cancer. Learn ...

  20. Aerodigestive cancers: laryngeal cancer.

    Science.gov (United States)

    Haws, Luke; Haws, Bryn Taylor

    2014-09-01

    Cancers of the larynx account for approximately 12,000 new cancer cases per year in the United States. The most common risk factors are tobacco and alcohol use, but human papillomavirus (HPV) has been identified in 26.6% of laryngeal cancers. Symptoms develop as the tumor infiltrates the vocal cords and/or surrounding structures, and patients commonly present with hoarseness or cough. Histologically, the vast majority of tumors are squamous cell carcinomas, which, for staging purposes, are categorized by subsite. These develop most often from the glottis, followed by the supraglottis and subglottis. Survival rates for early- and late-stage disease range from 56% to 93% and 29% to 56%, respectively. Unlike with other head and neck cancers, the prognostic significance of HPV-related laryngeal cancer is unclear. Advances in organ-preserving surgical techniques allow patients to maintain physiologic functions without compromising survival rates, especially for early-stage disease. Patients requiring more intensive treatment, including total laryngectomy and chemoradiation, will experience significant morbidity and lifestyle changes. The ability to communicate using a voice prosthesis is of primary importance, and the prosthesis must be tailored to each patient's needs and preferences. For patients with metastatic or nonresectable disease, palliative care should be considered. PMID:25198384

  1. Prostate cancer - resources

    Science.gov (United States)

    Resources - prostate cancer ... The following organizations are good resources for information on prostate cancer : American Cancer Society -- www.cancer.org/cancer/prostatecancer/index National Cancer Institute -- www.cancer.gov/cancertopics/ ...

  2. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Bladder Cancer Breast Cancer Colorectal Cancer Kidney (Renal Cell) Cancer Leukemia Lung Cancer Lymphoma Pancreatic Cancer Prostate ... grade, which refers to how abnormal the cancer cells look under a microscope. Grade provides clues about ...

  3. Understanding Cancer Prognosis

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    Full Text Available ... Types Recurrent Cancer Common Cancer Types Bladder Cancer Breast Cancer Colorectal Cancer Kidney (Renal Cell) Cancer Leukemia Lung ... Advisory Board Meetings Cancer Currents Blog Research Findings Drug Approvals Precision Medicine Leadership Views 2017 Annual Plan & ...

  4. What Is Breast Cancer?

    Science.gov (United States)

    ... Next Topic Types of breast cancers What is breast cancer? Breast cancer starts when cells in the breast ... breast cancer? ” and Non-cancerous Breast Conditions . How Breast Cancer Spreads Breast cancer can spread through the lymph ...

  5. Cryotherapy for prostate cancer

    Science.gov (United States)

    Cryosurgery-prostate cancer; Cryoablation-prostate cancer ... Prostate Cancer. American Cancer Society. www.cancer.org/cancer/prostatecancer/detailedguide/prostate-cancer-treating-cryosurgery. Accessed August 31, 2015. Horwich ...

  6. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... about Advanced Cancer Research Managing Cancer Care Finding Health Care Services Advance Directives Using Trusted Resources Understanding Cancer ... Cancer Advanced Cancer & Caregivers Managing Cancer Care Finding Health Care Services Advance Directives Using Trusted Resources Cancer Types ...

  7. Understanding Cancer Prognosis

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    Full Text Available ... Search About Cancer Causes and Prevention Risk Factors Genetics Cancer Prevention Overview Cancer Prevention Overview–for health ... Is Cancer Cancer Statistics Causes & Prevention Risk Factors Genetics Cancer Prevention Overview Screening Cancer Screening Overview Screening ...

  8. Diet and cancer

    Science.gov (United States)

    Fiber and cancer; Cancer and fiber; Nitrates and cancer; Cancer and nitrates ... DIET AND BREAST CANCER The link between nutrition and breast cancer has been well studied. To reduce risk of breast cancer the American ...

  9. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Talking about Advanced Cancer Coping with Your Feelings Planning for Advanced Cancer Advanced Cancer and Caregivers Questions ... Talking About Advanced Cancer Coping With Your Feelings Planning for Advanced Cancer Advanced Cancer & Caregivers Managing Cancer ...

  10. Cancer screening

    OpenAIRE

    Krishna Prasad

    1987-01-01

    Cancer screening is a means to detect cancer early with the goal of decreasing morbidity and mortality. At present, there is a reasonable consensus regarding screening for breast, cervical and colorectal cances and the role of screening is under trial in case of cancers of the lung,  ovaries and prostate. On the other hand, good screening tests are not available for some of the commonest cancers in India like the oral, pharyngeal, esophageal and stomach cancers.

  11. Correlation of complement receptor type 2 with senile plaque and neurofibrillar tangles in the hippocampal and temporal isocortex brain in patients with Alzheimer disease%阿尔茨海默病患者海马及颞叶脑组织中老年斑和神经纤维缠结与补体受体 2型的关系

    Institute of Scientific and Technical Information of China (English)

    张祥建; Patrick L.McGeer

    2004-01-01

    BACKGROUND:Whether the constant existence of inflammatory reaction during the onset of Alzheimer disease(AD)is positively correlated with the aggravation of the disease. OBJECTIVE:To investigate the expressional characteristics of complement receptor type 2(CR2)in the hippocampal and temporal isocortex brain tissue in patients with AD. DESIGN:Sampling investigation. SETTING and PARTICIPANTS:Setting:Kinsmen Laboratory of Neurological Research,University of British Columbia.All the patients' diagnosis was confirmed by routine neuropathological examination in the hospital of University of British Columbia.The study group consisted of the hippocampal and temporal isocortex brain tissues of 19 AD patients while the control group consisted of those of one patient with Parkinson disease(PD),one with familial PD,three with multiple sclerosis,five with Pick's disease,four with cancer,two with cardiovascular disease,one with sepsis and one patient with chronic obstructive pulmonary disease.The tonsil and spleen tissues were used as positive controls. INTERVENTIONS:CR2 monoclonal and polyclonal antibody were used as the first antibody,the methods of immunohistochemistry and Western blotting were used in this study. MAIN OUTCOME MEASURES:The expression of CR2 in the brain tissues of patients in each group. RESULTS:The follicular dendritic cells(FDC)in the spleen and tonsil tissues were intensely stained by CR2 antibodies.The antibody to CR2 also stained occasional round cells in the control group.In the hippocampal and temporal isocortex tissues of 19 patients with AD,the senile plaques and neurofibrillar tangles which were formed by degenerative neurites surrounding amyloid core were both stained strongly by CR2. CONCLUSION:CR2 may play a harmful role in the development of inflammation in AD.%背景:阿尔茨海默病 (Alzheimer disease,AD)发病过程中炎症反应的持续存在是否与病情加重呈正相关性. 目的:研究补体受体 2型 (CR2)在 AD患者海马、

  12. Cancer treatments

    Science.gov (United States)

    ... focused beam of light to destroy cancer cells. Laser therapy can be used to: Destroy tumors and precancerous growths Shrink tumors that are blocking the stomach, colon, or esophagus Help treat cancer symptoms, such as bleeding Seal nerve endings after ...

  13. Cancer prevention

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Introduction A 44 year old woman attends your surgery,distressed by the fact that her closest friend has just been given a diagnosis of colorectal cancer. She wants to know how to minimise her risk of developing cancer.

  14. Occupational Cancer

    Science.gov (United States)

    ... on Carcinogens NIOSH Pocket Guide Diesel Exhaust in Miners Study (DEMS) Recent NIOSH Research on Cancer Risk Factors Regulation and Policy OSHA Standards Surveillance NIOSH Data & Statistics by Industry Sector - Cancer Click on one ...

  15. Eye Cancer

    Science.gov (United States)

    Cancer of the eye is uncommon. It can affect the outer parts of the eye, such as the eyelid, which are made up ... adults are melanoma and lymphoma. The most common eye cancer in children is retinoblastoma, which starts in ...

  16. Oral Cancer

    Science.gov (United States)

    ... use. Some oral cancers are linked to human papilloma virus (HPV) infections of the mouth and throat. ... The number of oropharyngeal cancers linked to human papilloma virus (HPV) has risen dramatically over the past ...

  17. Cervical Cancer

    Science.gov (United States)

    ... Cervical cancer is caused by a virus called HPV. The virus spreads through sexual contact. Most women's bodies are able to fight HPV infection. But sometimes the virus leads to cancer. You're at higher risk ...

  18. Nasal Cancer

    Science.gov (United States)

    ... the way to your throat as you breathe. Cancer of the nasal cavity and paranasal sinuses is ... be like those of infections. Doctors diagnose nasal cancer with imaging tests, lighted tube-like instruments that ...

  19. Gallbladder Cancer

    Science.gov (United States)

    ... your gallbladder and liver to your small intestine. Cancer of the gallbladder is rare. It is more ... the abdomen It is hard to diagnose gallbladder cancer in its early stages. Sometimes doctors find it ...

  20. Cancer Disparities

    Science.gov (United States)

    Basic information about cancer disparities in the U.S., factors that contribute to the disproportionate burden of cancer in some groups, and examples of disparities in incidence and mortality among certain populations.

  1. Prostate Cancer

    Science.gov (United States)

    ... man's bladder that produces fluid for semen. Prostate cancer is common among older men. It is rare ... younger than 40. Risk factors for developing prostate cancer include being over 65 years of age, family ...

  2. Esophageal Cancer

    Science.gov (United States)

    ... from your throat to your stomach. Early esophageal cancer usually does not cause symptoms. Later, you may ... You're at greater risk for getting esophageal cancer if you smoke, drink heavily, or have acid ...

  3. Intestinal Cancer

    Science.gov (United States)

    ... connects your stomach to your large intestine. Intestinal cancer is rare, but eating a high-fat diet ... increase your risk. Possible signs of small intestine cancer include Abdominal pain Weight loss for no reason ...

  4. Colorectal Cancer

    Science.gov (United States)

    ... rectum are part of the large intestine. Colorectal cancer occurs when tumors form in the lining of ... men and women. The risk of developing colorectal cancer rises after age 50. You're also more ...

  5. Thymus Cancer

    Science.gov (United States)

    ... cell. These cells help protect you from infections. Cancer of the thymus is rare. You are more ... Sometimes there are no symptoms. Other times, thymus cancer can cause A cough that doesn't go ...

  6. Pancreatic Cancer

    Science.gov (United States)

    ... hormones that help control blood sugar levels. Pancreatic cancer usually begins in the cells that produce the juices. Some risk factors for developing pancreatic cancer include Smoking Long-term diabetes Chronic pancreatitis Certain ...

  7. Profiling cancer

    DEFF Research Database (Denmark)

    Ciro, Marco; Bracken, Adrian P; Helin, Kristian

    2003-01-01

    In the past couple of years, several very exciting studies have demonstrated the enormous power of gene-expression profiling for cancer classification and prediction of patient survival. In addition to promising a more accurate classification of cancer and therefore better treatment of patients......, gene-expression profiling can result in the identification of novel potential targets for cancer therapy and a better understanding of the molecular mechanisms leading to cancer....

  8. Prostate Cancer

    OpenAIRE

    Eggener, Scott

    2011-01-01

    Prostate cancer continues to be a significant public health issue worldwide, particularly in countries where men have life expectancies long enough to clinically manifest the disease. In many countries, it remains one of the leading causes of cancer-related morbidity and mortality.Although significant progress has been made over the past few decades, many elements regarding the diagnosis and management of patients with prostate cancer remain enigmatic. In this Prostate Cancer special issue, o...

  9. Prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, G.P.; Kuss, R., Khoury, S.; Chatelain, C.; Denis, L.

    1987-01-01

    This book contains over 70 selections. Some of the titles are: Place of the Computed Tomography in the Staging of Prostatic Cancer; Magnetic Resonance Imaging (MRI) in Staging of the Prostatic Cancer; Magnetic Resonance Imaging of the Prostate; Long-Term Results in Radiotherapy of Prostatic Cancer; Interstitial Irradiation Using I-125 Seeds; and Treatment of Cancer of the Prostate by Use of Physiotherapy: Long-Term Results.

  10. Colon cancer - resources

    Science.gov (United States)

    Resources - colon cancer ... The following organizations are good resources for information on colon cancer : American Cancer Society -- www.cancer.org/cancer/colonandrectumcancer/index Colon Cancer Alliance -- www.ccalliance.org National ...

  11. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... about Advanced Cancer Research Managing Cancer Care Finding Health Care Services Advance Directives Using Trusted Resources Financial Toxicity ... Cancer Advanced Cancer & Caregivers Managing Cancer Care Finding Health Care Services Advance Directives Using Trusted Resources Cancer Types ...

  12. Understanding Cancer Prognosis

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    Full Text Available ... Partners & Collaborators Spotlight on Scientists Research Areas Cancer Biology Cancer Genomics Causes of Cancer Diagnosis Prevention Screening & ... Collaborators Spotlight on Scientists NCI Research Areas Cancer Biology Cancer Genomics Causes of Cancer Diagnosis Prevention Screening & ...

  13. Understanding Cancer Prognosis

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    Full Text Available ... Cancer Research Managing Cancer Care Finding Health Care Services Advance Directives Using Trusted Resources Understanding Cancer What ... Cancer & Caregivers Managing Cancer Care Finding Health Care Services Advance Directives Using Trusted Resources Cancer Types Adolescents ...

  14. Lung Cancer Prevention

    Science.gov (United States)

    ... Treatment Lung Cancer Prevention Lung Cancer Screening Research Lung Cancer Prevention (PDQ®)–Patient Version What is prevention? Go ... to keep cancer from starting. General Information About Lung Cancer Key Points Lung cancer is a disease in ...

  15. Stomach (Gastric) Cancer Prevention

    Science.gov (United States)

    ... Treatment Stomach Cancer Prevention Stomach Cancer Screening Research Stomach (Gastric) Cancer Prevention (PDQ®)–Patient Version What is ... to keep cancer from starting. General Information About Stomach Cancer Key Points Stomach (gastric) cancer is a ...

  16. Learning about Prostate Cancer

    Science.gov (United States)

    ... of Information on Prostate Cancer What is prostate cancer? Prostate cancer is the most common cancer in American ... of page Additional Resources of Information on Prostate Cancer Prostate Cancer [nlm.nih.gov] From Medline Plus Medical ...

  17. What is Prostate Cancer?

    Science.gov (United States)

    ... Research Get Involved Find Local ACS Learn About Cancer » Prostate Cancer » Detailed Guide » What is prostate cancer? Share ... how cancers start and spread, see What Is Cancer? Prostate cancer begins when cells in the prostate gland ...

  18. Oral Cancer Prevention

    Science.gov (United States)

    ... Quit General Information About Oral Cavity and Oropharyngeal Cancer Oral cavity cancer and oropharyngeal cancer are diseases in ... about how you might lower your risk of cancer. Oral cavity cancer and oropharyngeal cancer are two different ...

  19. Throat or larynx cancer

    Science.gov (United States)

    Vocal cord cancer; Throat cancer; Laryngeal cancer; Cancer of the glottis; Cancer of oropharynx or hypopharynx ... use tobacco are at risk of developing throat cancer. Drinking too much alcohol over a long time ...

  20. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Role in Cancer Research Intramural Research Extramural Research Bioinformatics and Cancer NCI-Designated Cancer Centers Frederick National ... Role in Cancer Research Intramural Research Extramural Research Bioinformatics and Cancer NCI-Designated Cancer Centers Frederick National ...

  1. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Cancer Types Adolescents and Young Adults with Cancer Reports, Research, and Literature Quiz Cancers by Body Location/ ... the Precision Medicine Initiative® Cancer Moonshot Progress Annual Report to the Nation Cancer Snapshots Milestones in Cancer ...

  2. Breast cancer

    CERN Multimedia

    2002-01-01

    "Cancer specialists will soon be able to compare mammograms with computerized images of breast cancer from across Europe, in a bid to improve diagnosis and treatment....The new project, known as MammoGrid, brings together computer and medical imaging experts, cancer specialists, radiologists and epidemiologists from Bristol, Oxford, Cambridge, France and Italy" (1 page).

  3. Cancer Triptych.

    Science.gov (United States)

    Faulkner, Sandra L

    2016-08-01

    The author uses personal narrative to show how the cold cloak of cancer covered her family during the polar vortex of 2013-2014. The use of a triptych form hinges together related themes of containment, coping, communicative responses, and social support after a cancer diagnosis. This narrative demonstrates the multiple responses and communicative coping strategies to a cancer diagnosis. PMID:26752448

  4. Pancreatic cancer

    OpenAIRE

    Kocher, Hemant M.; Alrawashdeh, Wasfi

    2010-01-01

    Pancreatic cancer is the fourth most common cause of cancer death in higher-income countries, with 5-year survival only 10% (range 7%–25%), even in people presenting with early-stage cancer. Risk factors include age, smoking, chronic pancreatitis, a family history, and dietary factors. Diabetes mellitus may also increase the risk.

  5. Breast Cancer

    Science.gov (United States)

    Breast cancer affects one in eight women during their lives. No one knows why some women get breast cancer, but there are many risk factors. Risks ... the risk. Women who have family members with breast or ovarian cancer may wish to be tested ...

  6. Testicular Cancer

    Science.gov (United States)

    ... of skin behind the penis. You can get cancer in one or both testicles. Testicular cancer mainly affects young men between the ages of ... undescended testicle Have a family history of the cancer Symptoms include pain, swelling, or lumps in your ...

  7. Functional microRNAs in Alzheimer’s disease and cancer: differential regulation of common mechanisms and pathways

    Directory of Open Access Journals (Sweden)

    Kelly N Holohan

    2013-01-01

    Full Text Available Two of the main research priorities in the United States are cancer and neurodegenerative diseases, which are attributed to abnormal patterns of cellular behavior. MicroRNAs (miRNA have been implicated as regulators of cellular metabolism, and thus are an active topic of investigation in both disease areas. There is presently a more extensive body of work on the role of miRNAs in cancer compared to neurodegenerative diseases, and therefore it may be useful to examine whether there is any concordance between the functional roles of miRNAs in these diseases. As a case study, the roles of miRNAs in Alzheimer’s disease (AD and their functions in various cancers will be compared. A number of miRNA expression patterns are altered in individuals with AD compared with healthy older adults. Among these, some have also been shown to correlate with neuropathological changes including plaque and tangle accumulation, as well as expression levels of other molecules known to be involved in disease pathology. Importantly, these miRNAs have also been shown to have differential expression and or functional roles in various types of cancer. To examine possible intersections between miRNA functions in cancer and AD, we review the current literature on eight of these miRNAs in cancer and AD, focusing on their roles in known biological pathways. We propose a pathway-driven model in which some molecular processes show an inverse relationship between cancer and neurodegenerative disease (e.g., proliferation and apoptosis whereas others are more parallel in their activity (e.g., immune activation and inflammation. A critical review of these and other molecular mechanisms in cancer may shed light on the pathophysiology of AD, and highlight key areas for future research. Conclusions from this work may be extended to other neurodegenerative diseases for which some molecular pathways have been identified but which have not yet been extensively researched for mi

  8. Lymphedema After Surgery in Patients With Endometrial Cancer, Cervical Cancer, or Vulvar Cancer

    Science.gov (United States)

    2014-12-23

    Lymphedema; Stage IA Cervical Cancer; Stage IA Uterine Corpus Cancer; Stage IA Vulvar Cancer; Stage IB Cervical Cancer; Stage IB Uterine Corpus Cancer; Stage IB Vulvar Cancer; Stage II Uterine Corpus Cancer; Stage II Vulvar Cancer; Stage IIA Cervical Cancer; Stage IIIA Vulvar Cancer; Stage IIIB Vulvar Cancer; Stage IIIC Vulvar Cancer; Stage IVB Vulvar Cancer

  9. Cervical Cancer

    Centers for Disease Control (CDC) Podcasts

    2007-03-06

    Did you know that cervical cancer rates differ by race/ethnicity and region? Or that cervical cancer can usually be prevented if precancerous cervical lesions are found by a Pap test and treated? Find out how getting regular Pap tests can save a woman's life.  Created: 3/6/2007 by National Breast and Cervical Cancer Early Detection Program.   Date Released: 4/25/2007.

  10. Cancer cachexia

    OpenAIRE

    Raghu Dhanapal; T R Saraswathi; N Govind Rajkumar

    2011-01-01

    Cancer cachexia is a wasting syndrome characterized by weight loss, anorexia, asthenia and anemia. The pathogenicity of this syndrome is multifactorial, due to a complex interaction of tumor and host factors. The signs and symptoms of cachexia are considered as the prognostic parameters in cancer patients. This review gives an emphasis on the various mechanisms involved in cachexia and an insight into head and neck cancer cachexia.

  11. SKIN CANCER

    OpenAIRE

    Made Putri Hendaria; AAGN Asmarajaya; Sri Maliawan

    2013-01-01

    Skin is an organ which protect the human body from the environment. It was build by milion cells. According to the changes in human lifestyle which tends to unhealthy life, increasing ultraviolet radiation, toxins, and genetics makes the cells who build the skin do the abnormal growth being cancer cells. Classification of skin cancer is according the most common three types, they are Basal Cell Carcinoma, Squamous Cell Carcinoma, and Malignant Melanoma. More than 3,5 milion skin cancer cases ...

  12. Prostate cancer

    International Nuclear Information System (INIS)

    This work is about diagnosis, treatment and monitoring of prostate cancer. The techniques used are: transrectal ultrasound, laparascopy, bone scan, chest x-ray, radiography, chemoterapy and radiotherapy

  13. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Kidney (Renal Cell) Cancer Leukemia Lung Cancer Lymphoma Pancreatic Cancer Prostate Cancer Skin Cancer Thyroid Cancer Uterine Cancer ... on YouTube. Barbara’s attitude since her diagnosis with pancreatic cancer? No doctor is going to tell her how ...

  14. Cancer in Patients With Gabapentin (GPRD)

    Science.gov (United States)

    2012-02-02

    Pain, Neuropathic; Epilepsy; Renal Pelvis Cancer; Pancreatic Cancer; Breast Cancer; Nervous System Cancer; Chronic Pancreatitis; Stomach Cancer; Renal Cell Carcinoma; Diabetes; Bladder Cancer; Bone and Joint Cancer; Penis Cancer; Anal Cancer; Cancer; Renal Cancer

  15. What Is Bone Cancer?

    Science.gov (United States)

    ... our document called Osteosarcoma . Chondrosarcoma: Chondrosarcoma (KON-droh-sar-KOH-muh) is a cancer of cartilage cells. ... AdditionalResources Other Resources and References Cancer Information Cancer Basics Cancer Prevention & Detection Signs & Symptoms of Cancer Treatments & ...

  16. Chemotherapy for Testicular Cancer

    Science.gov (United States)

    ... chemotherapy and stem cell transplant for testicular cancer Chemotherapy for testicular cancer Chemotherapy (chemo) is the use ... Symptoms of Cancer Treatments & Side Effects Cancer Facts & Statistics News About Cancer Expert Voices Blog Programs & Services ...

  17. What Causes Thyroid Cancer?

    Science.gov (United States)

    ... TOPICS Document Topics GO » SEE A LIST » Thyroid cancer risk factors What causes thyroid cancer? Can thyroid cancer be prevented? Previous Topic Thyroid cancer risk factors Next Topic Can thyroid cancer be prevented? What ...

  18. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Adult Cancers Metastatic Cancer Recurrent Cancer Research NCI’s Role in Cancer Research Intramural Research Extramural Research Bioinformatics ... Terminology Resources NCI Data Catalog Cryo-EM NCI's Role in Cancer Research Intramural Research Extramural Research Bioinformatics ...

  19. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Side Effects Clinical Trials Cancer Drugs Complementary & Alternative Medicine Coping Feelings & Cancer Adjusting to Cancer Self Image & Sexuality Day to Day Life Survivorship For Family & Friends Questions to Ask About Cancer Advanced Cancer ...

  20. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Genetics Cancer Prevention Overview Cancer Prevention Overview–for health professionals Research Cancer Screening Cancer Screening Overview Cancer Screening Overview–for health professionals Screening Tests Research Diagnosis and Staging Symptoms ...

  1. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Ask About Cancer Research Advanced Cancer Choices for Care Talking about Advanced Cancer Coping with Your Feelings ... to Ask about Advanced Cancer Research Managing Cancer Care Finding Health Care Services Advance Directives Using Trusted ...

  2. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Laboratory for Cancer Research Partners & Collaborators Spotlight on Scientists Research Areas Cancer Biology Cancer Genomics Causes of ... Centers Frederick National Lab Partners & Collaborators Spotlight on Scientists NCI Research Areas Cancer Biology Cancer Genomics Causes ...

  3. Lung Cancer Screening

    Science.gov (United States)

    ... Treatment Lung Cancer Prevention Lung Cancer Screening Research Lung Cancer Screening (PDQ®)–Patient Version What is screening? Go ... These are called diagnostic tests . General Information About Lung Cancer Key Points Lung cancer is a disease in ...

  4. Breast Cancer: Treatment Options

    Science.gov (United States)

    ... Breast Cancer > Breast Cancer - Treatment Options Request Permissions Breast Cancer - Treatment Options Approved by the Cancer.Net Editorial ... recommendations for ovarian ablation . Hormonal therapy for metastatic breast cancer Hormonal therapies are also commonly used to treat ...

  5. Prostate Cancer (Radiation Therapy)

    Science.gov (United States)

    ... Physician Resources Professions Site Index A-Z Prostate Cancer Treatment Prostate cancer overview? What are my treatment options? What ... any new developments in treating my disease? Prostate cancer overview Prostate cancer is the most common form of cancer ...

  6. Progress against Prostate Cancer

    Science.gov (United States)

    ... this page please turn Javascript on. Feature: Prostate Cancer Progress Against Prostate Cancer Past Issues / Winter 2010 Table of Contents ... Read More "Prostate Cancer" Articles Progress Against Prostate Cancer / Prostate Cancer Research Trial Helps John Spencer Treat His ...

  7. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Caregivers Questions to Ask about Advanced Cancer Research Managing Cancer Care Finding Health Care Services Advance Directives ... Feelings Planning for Advanced Cancer Advanced Cancer & Caregivers Managing Cancer Care Finding Health Care Services Advance Directives ...

  8. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Services Advance Directives Using Trusted Resources Cancer Types Adolescents and Young Adults with Cancer Reports, Research, and Literature Quiz Cancers by Body Location/System Childhood Cancers Late Effects of Childhood Cancer Treatment Pediatric Supportive Care Unusual ...

  9. Oral Cancer Exam

    Science.gov (United States)

    ... Topics > Oral Cancer > The Oral Cancer Exam The Oral Cancer Exam Main Content See a step-by-step video explaining what happens during an oral cancer examination. An oral cancer exam is painless and quick — it takes ...

  10. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Cancer Prevention Overview Cancer Prevention Overview–for health professionals Research Cancer Screening Cancer Screening Overview Cancer Screening Overview–for health professionals Screening Tests Research Diagnosis and Staging Symptoms Diagnosis ...

  11. Children's cancer centers

    Science.gov (United States)

    Pediatric cancer center; Pediatric oncology center; Comprehensive cancer center ... Treating childhood cancer is not the same as treating adult cancer. The cancers are different. So are the treatments and the ...

  12. What Is Cancer?

    Science.gov (United States)

    ... Kidney/Wilms Tumor Liver Cancer Lymphoma (Non-Hodgkin) Lymphoma (Hodgkin) Neuroblastoma Osteosarcoma Retinoblastoma Rhabdomyosarcoma Skin Cancer Soft Tissue Sarcoma Thyroid Cancer Understanding Children's Cancer Anxiety Around Procedures Childhood Cancer Statistics Late ...

  13. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... with Cancer Feelings and Cancer Adjusting to Cancer Self Image & Sexuality Day-to-Day Life Support for ... Alternative Medicine Coping Feelings & Cancer Adjusting to Cancer Self Image & Sexuality Day to Day Life Survivorship Support ...

  14. Skin Cancer Screening

    Science.gov (United States)

    ... Genetics of Skin Cancer Skin Cancer Screening Research Skin Cancer Screening (PDQ®)–Patient Version What is screening? Go ... These are called diagnostic tests . General Information About Skin Cancer Key Points Skin cancer is a disease in ...

  15. Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Scott Eggener

    2011-01-01

    Full Text Available Prostate cancer continues to be a significant public health issue worldwide, particularly in countries where men have life expectancies long enough to clinically manifest the disease. In many countries, it remains one of the leading causes of cancer-related morbidity and mortality.

  16. Breast Cancer

    Science.gov (United States)

    ... I found something when I did my breast self-exam. What should I do now? How often should I have mammograms? I have breast cancer. What are my treatment options? How often should I do breast self-exams? I have breast cancer. Is my daughter ...

  17. Targeted Therapies for Kidney Cancer

    Science.gov (United States)

    ... for kidney cancer Targeted therapies for kidney cancer Biologic therapy (immunotherapy) for kidney cancer Chemotherapy for kidney cancer Pain control for kidney cancer Treatment choices by stage for ...

  18. Radiation Therapy for Cancer

    Science.gov (United States)

    ... Cancers by Body Location Childhood Cancers Adolescent & Young Adult Cancers Metastatic Cancer Recurrent Cancer Research NCI’s Role in ... the affected area). Damage to the bowels, causing diarrhea and ... a second cancer caused by radiation exposure. Second cancers that develop ...

  19. Breast Cancer -- Male

    Science.gov (United States)

    ... Home > Types of Cancer > Breast Cancer in Men Breast Cancer in Men This is Cancer.Net’s Guide to Breast Cancer in Men. Use the menu below to choose ... social workers, and patient advocates. Cancer.Net Guide Breast Cancer in Men Overview Statistics Risk Factors and Prevention ...

  20. Cancer world

    International Nuclear Information System (INIS)

    The author attempts to point out the relationships between various factors of our environment favouring disease (profession, chemicals, air pollution, nuclear power plants, ultra-violet rays etc.) respectively our ways of living (nutrition, drink, smoking), and the incidence and frequence of cancer. In his opinion, cancer is the toll man has to pay for industrialization and the destruction of the environment, and cancer therapy must begin long before the patient's treatment by changing that same einvironment. The different carcinogenous factors are discussed in detail and each chapter concludes with recommendations to those concerned and request for legislation. (MG)

  1. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Chat Publications Dictionary Menu Contact Dictionary Search About Cancer Causes and Prevention Risk Factors Genetics Cancer Prevention Overview Cancer Prevention Overview–for ...

  2. Breast Cancer

    Science.gov (United States)

    ... click the brackets in the lower right-hand corner of the video screen. To reduce the videos, ... with breast cancer are under way. With early detection, and prompt and appropriate treatment, the outlook for ...

  3. Breast cancer

    Science.gov (United States)

    ... perform breast self-exams each month. However, the importance of self-exams for detecting breast cancer is ... M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health ...

  4. Oral cancer

    Science.gov (United States)

    ... the immune system (immunosuppressants) Poor dental and oral hygiene Some oral cancers begin as a white plaque ( leukoplakia ) or ... use Visiting the dentist regularly and practicing good oral hygiene

  5. Vulvar Cancer

    Science.gov (United States)

    ... a human papillomavirus (HPV) infection or have a history of genital warts. Your health care provider diagnoses vulvar cancer with a physical exam and a biopsy. Treatment varies, depending on your overall health and ...

  6. Cancer nanotheranostics

    CERN Document Server

    Gopinath, P; Matai, Ishita; Bhushan, Bharat; Malwal, Deepika; Sachdev, Abhay; Dubey, Poornima

    2015-01-01

    This Brief provides a clear insight of the recent advances in the field of cancer theranostics with special emphasis upon nano scale carrier molecules (polymeric, protein and lipid based) and imaging agents (organic and inorganic).

  7. Breast cancer

    International Nuclear Information System (INIS)

    This article is about the diagnosis, treatment and monitoring of breast cancer. Positive diagnosis is based on clinical mammary exam, mammography, mammary ultrasonography, and histological study. Before the chemotherapy and radiotherapy treatment are evaluated the risks

  8. Cervical Cancer

    Science.gov (United States)

    ... 162 KB) This information in Spanish (en español) Female reproductive system Select image to view larger Related ... D., FACS, Captain, U.S. Public Health Service Medical Director, National Breast and Cervical Cancer Early Detection Program, ...

  9. Surviving Cancer

    Science.gov (United States)

    ... his or her health status, when diagnosed with cancer may have an effect on their survival and recovery. Older adults are more likely to have other health conditions such as diabetes and heart disease. Managing these conditions can complicate ...

  10. Prostate cancer

    DEFF Research Database (Denmark)

    Chabanova, Elizaveta; Balslev, Ingegerd; Logager, Vibeke;

    2011-01-01

    To investigate diagnostic accuracy of detection of prostate cancer by magnetic resonance: to evaluate the performance of T2WI, DCEMRI and CSI and to correlate the results with biopsy and radical prostatectomy histopathological data....

  11. Vaginal cancer

    Science.gov (United States)

    Hacker NF. Vulvar and vaginal cancer. In: Hacker NF, Gambone JC, Hobel CJ, eds. Hacker and Moore's Essentials of Obstetrics and Gynecology . 6th ed. Philadelphia, PA: Elsevier; 2016:chap 40. Jhingran ...

  12. Prostate cancer

    DEFF Research Database (Denmark)

    Chabanova, Elizaveta; Balslev, Ingegerd; Logager, Vibeke;

    2011-01-01

    To investigate diagnostic accuracy of detection of prostate cancer by magnetic resonance: to evaluate the performance of T2WI, DCEMRI and CSI and to correlate the results with biopsy and radical prostatectomy histopathological data.......To investigate diagnostic accuracy of detection of prostate cancer by magnetic resonance: to evaluate the performance of T2WI, DCEMRI and CSI and to correlate the results with biopsy and radical prostatectomy histopathological data....

  13. Oral Cancer Exam

    Medline Plus

    Full Text Available ... Topics > Oral Cancer > Oral Cancer Exam Video Oral Cancer Exam Video This video shows what happens during an oral cancer examination. Quick and painless, the exam can detect ...

  14. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... and Cancer Adjusting to Cancer Self Image & Sexuality Day-to-Day Life Support for Caregivers Survivorship Questions to Ask ... Feelings & Cancer Adjusting to Cancer Self Image & Sexuality Day to Day Life Survivorship Support for Caregivers Questions ...

  15. Is Pancreatic Cancer Hereditary?

    Science.gov (United States)

    ... Board Patient Education / Basics of Pancreatic Cancer Is pancreatic cancer hereditary? Cancer of the pancreas is a genetic ... found in cigarette smoke. The genetics of hereditary pancreatic cancer is a focus of research at Johns Hopkins. ...

  16. Alcohol and Cancer Risk

    Science.gov (United States)

    ... Overview Cancer Prevention Overview–for health professionals Research Alcohol and Cancer Risk On This Page What is ... in the risk of colorectal cancer. Research on alcohol consumption and other cancers: Numerous studies have examined ...

  17. Cancer and African Americans

    Science.gov (United States)

    ... Population Profiles > Black/African American > Cancer Cancer and African Americans African Americans have the highest mortality rate ... 65MB] At a glance – Top Cancer Sites for African Americans (2008-2012) Cancer Incidence Rates per 100, ...

  18. Endometrial Cancer Risk Factors

    Science.gov (United States)

    ... cancer? Next Topic What causes endometrial cancer? Endometrial cancer risk factors A risk factor is anything that affects your ... to obesity, which is a well-known endometrial cancer risk factor. Many scientists think this is the main way ...

  19. Lung cancer - small cell

    Science.gov (United States)

    Cancer - lung - small cell; Small cell lung cancer; SCLC ... About 15% of all lung cancer cases are SCLC. Small cell lung cancer is slightly more common in men than women. Almost all cases of SCLC ...

  20. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... to Z List of Cancer Drugs Complementary & Alternative Medicine (CAM) Questions to Ask about Your Treatment Research ... Side Effects Clinical Trials Cancer Drugs Complementary & Alternative Medicine Coping Feelings & Cancer Adjusting to Cancer Self Image & ...

  1. American Cancer Society

    Science.gov (United States)

    ... about why this happens. Fight Breast Cancer with Fashion Shop Lane Bryant's cause collection and 10% of ... Cancer Facts & Statistics News About Cancer Expert Voices Blog Programs & Services Breast Cancer Support TLC Hair Loss & ...

  2. Ovarian Cancer Stage I

    Science.gov (United States)

    ... An inset shows cancer cells in the pelvic peritoneum. Also shown are the fallopian tubes, uterus, cervix, ... c) cancer cells are found in the pelvic peritoneum. Topics/Categories: Anatomy -- Gynecologic Cancer Types -- Ovarian Cancer ...

  3. Ovarian Cancer Stage II

    Science.gov (United States)

    ... primary peritoneal cancer) shows cancer in the pelvic peritoneum. Also shown are the cervix and vagina. In ... peritoneal cancer, cancer is found in the pelvic peritoneum and has not spread there from another part ...

  4. Breast Cancer Treatment

    Science.gov (United States)

    ... of Breast & Gynecologic Cancers Breast Cancer Screening Research Breast Cancer Treatment (PDQ®)–Patient Version General Information About Breast Cancer Go to Health Professional Version Key Points Breast ...

  5. Surgery for Breast Cancer

    Science.gov (United States)

    ... Next Topic Breast-conserving surgery (lumpectomy) Surgery for breast cancer Most women with breast cancer have some type ... Relieve symptoms of advanced cancer Surgery to remove breast cancer There are two main types of surgery to ...

  6. Stages of Breast Cancer

    Science.gov (United States)

    ... of Breast & Gynecologic Cancers Breast Cancer Screening Research Breast Cancer Treatment (PDQ®)–Patient Version General Information About Breast Cancer Go to Health Professional Version Key Points Breast ...

  7. Learning about Breast Cancer

    Science.gov (United States)

    ... genetic terms used on this page Learning About Breast Cancer What do we know about heredity and breast ... Cancer What do we know about heredity and breast cancer? Breast cancer is a common disease. Each year, ...

  8. Prostate cancer - treatment

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000403.htm Prostate cancer - treatment To use the sharing features on this ... a combination of drugs is recommended. References National Cancer Institute. Prostate cancer treatment (PDQ): Stages of prostate cancer. Updated ...

  9. Cancer of the Prostate

    Science.gov (United States)

    ... will die of this disease. Who Gets This Cancer? Prostate cancer occurs only in men, and it is ... Percent of New Cases by Age Group: Prostate Cancer Prostate cancer is most frequently diagnosed among men aged ...

  10. Uterine Cancer Statistics

    Science.gov (United States)

    ... Research AMIGAS Fighting Cervical Cancer Worldwide Stay Informed Statistics for Other Kinds of Cancer Breast Cervical Colorectal ( ... Skin Vaginal and Vulvar Cancer Home Uterine Cancer Statistics Language: English Español (Spanish) Recommend on Facebook Tweet ...

  11. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... and Cancer Adjusting to Cancer Self Image & Sexuality Day-to-Day Life For Family & Friends Survivorship Questions to Ask ... Feelings & Cancer Adjusting to Cancer Self Image & Sexuality Day to Day Life Survivorship For Family & Friends Questions ...

  12. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available Español 1-800-4-CANCER Live Chat Publications Dictionary Menu Contact Dictionary Search About Cancer Causes and Prevention Risk Factors Genetics Cancer Prevention Overview Cancer Prevention Overview–for health professionals Research ...

  13. Lung cancer - small cell

    Science.gov (United States)

    Cancer - lung - small cell; Small cell lung cancer; SCLC ... About 15% of all lung cancer cases are SCLC. Small cell lung cancer is slightly more common in men than women. Almost all cases of SCLC are ...

  14. Pancreatic Cancer Stage 3

    Science.gov (United States)

    ... 3 Description: Stage III pancreatic cancer; drawing shows cancer in the pancreas, common hepatic artery, and portal vein. Also shown ... and superior mesenteric artery. Stage III pancreatic cancer. Cancer ... near the pancreas. These include the superior mesenteric artery, celiac axis, ...

  15. Dealing with Cancer

    Science.gov (United States)

    ... Schoolwork and Hospital Stays Chemotherapy Hodgkin Lymphoma Non-Hodgkin Lymphoma Radiation Therapy When Cancer Keeps You Home Can I Have Children After Cancer Treatments? Steroids and Cancer Treatment Cancer ...

  16. Chemotherapy for Thyroid Cancer

    Science.gov (United States)

    ... cancer Next Topic Targeted therapy for thyroid cancer Chemotherapy for thyroid cancer Chemotherapy (chemo) uses anti-cancer drugs that are injected ... vein or muscle, or are taken by mouth. Chemotherapy is systemic therapy, which means that the drug ...

  17. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Feelings and Cancer Adjusting to Cancer Self Image & Sexuality Day-to-Day Life Support for Caregivers Survivorship ... Coping Feelings & Cancer Adjusting to Cancer Self Image & Sexuality Day to Day Life Survivorship Support for Caregivers ...

  18. Childhood Cancer Statistics

    Science.gov (United States)

    ... Shop With CureSearch Blog Donate Now Select Page Childhood Cancer Statistics Home > Understanding Children’s Cancer > Childhood Cancer Statistics Childhood Cancer Statistics – Graphs and Infographics Number of Diagnoses ...

  19. What Is Cancer?

    Science.gov (United States)

    ... unneeded cells. Cancer cells may be able to influence the normal cells, molecules, and blood vessels that ... Cancers . We also have collections of information on childhood cancers and cancers in adolescents and young adults . ...

  20. Skin Cancer Foundation

    Science.gov (United States)

    ... Host a Fundraising Event | About Us | Store The Skin Cancer Foundation The Skin Cancer Foundation is the ... A "Sunscreen Gene"? Skin Cancer Facts & Statistics The Skin Cancer Foundation's Champions for Change Gala 2016 Learn ...

  1. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Cancer Health Disparities Childhood Cancers Research Clinical Trials Global Health Key Initiatives The RAS Initiative NCI and ... Health Cancer Health Disparities Childhood Cancer Clinical Trials Global Health Key Initiatives Read about some of NCI's ...

  2. Diet and cancer

    Science.gov (United States)

    Fiber and cancer; Cancer and fiber; Nitrates and cancer; Cancer and nitrates ... daily. Lower your intake of processed meats, smoked, nitrite-cured, and salt-preserved foods; emphasize plant-based ...

  3. Cancer Biomarkers | Division of Cancer Prevention

    Science.gov (United States)

    This group promotes research to identify, develop, and validate biological markers for early cancer detection and cancer risk assessment. | Research to identify, develop and validate biomarkers for early cancer detection and risk assessment.

  4. Breast Cancer Overview

    Science.gov (United States)

    ... Other less common types of breast cancer include: Medullary Mucinous Tubular Metaplastic Papillary breast cancer Inflammatory breast cancer is a faster-growing type of cancer that accounts for about 1% to 5% of all breast cancers. Paget’s disease is a type of cancer that begins in ...

  5. Hyperthermia in Cancer Treatment

    Science.gov (United States)

    ... Cancers by Body Location Childhood Cancers Adolescent & Young Adult Cancers Metastatic Cancer Recurrent Cancer Research NCI’s Role in ... but these effects are uncommon ( 1 , 3 , 7 ). Diarrhea , nausea, and vomiting ... a standard treatment for cancer ( 1 , 3 , 6 , 7 ). Many clinical trials are ...

  6. Stages of Pancreatic Cancer

    Science.gov (United States)

    ... affect prognosis (chance of recovery) and treatment options. Pancreatic cancer is a disease in which malignant (cancer) cells form in the ... the cancer cells in the liver are actually pancreatic cancer cells. The disease is metastatic pancreatic cancer, not liver cancer. The ...

  7. [Gastrointestinal cancer].

    Science.gov (United States)

    Takahashi, Yutaka

    2004-08-01

    Although their sensitivity is not high, SCC, TPA and IAP are useful for esophageal cancer. The sensitivity of CEA, CA 19-9, is relatively high, especially in well-differentiated adenocarcinoma of gastric cancer with lymph node metastasis. AFP is specific to liver metastasis from gastric cancer, and CA 125 is also specific to peritoneal dissemination. CA 72-4 and NCC-ST-439 are useful markers for advanced staging. CEA, CA 19-9, is useful for colon cancer, especially for predicting preoperative staging. Half-life and doubling time of tumor markers is useful in some cases for the evaluation of operation and chemotherapy. We showed our data concerning postoperative CEA and/or CA 19-9 monitoring after operation for gastric cancer in 120 recurrent patients. Positivities of CEA and CA 19-9 for recurrence were 65.8% and 85.0%, respectively, both of which were significantly higher than the preoperative sensitivities (28.3% and 45.0%, respectively). In most patients with high levels of preoperative CEA and/or CA 19-9, these tumor markers increased again at recurrence. Recurrent diseases were detected between 5 months after detection by diagnostic imagings and 12 months before detection by diagnostic imagings (mean of 3.1+/-3.6 months before detection by diagnostic imagings) and between 10 months after detection by diagnostic imagings and 13 months before detection by diagnostic imagings (mean 2.2+/-3.9 months before detection by diagnostic imagings) by CEA and CA 19-9 monitorings, respectively. These results suggest that CEA and/or CA 19-9 monitoring after operation was useful to predict the recurrence of gastric cancer, especially in almost all the patients with high preoperative levels of these markers.

  8. Key Statistics for Thyroid Cancer

    Science.gov (United States)

    ... cancer? Next Topic Thyroid cancer risk factors Key statistics for thyroid cancer How common is thyroid cancer? ... remains very low compared with most other cancers. Statistics on survival rates for thyroid cancer are discussed ...

  9. Anyone Can Get Skin Cancer

    Science.gov (United States)

    ... Cancer Skin Cancer Screening Research Anyone Can Get Skin Cancer Order the free Anyone Can Get Skin Cancer ... true that only people with light skin get skin cancer? No. Anyone can get skin cancer. It's more ...

  10. Cancer cachexia

    Directory of Open Access Journals (Sweden)

    Kunze Philipp

    2003-11-01

    Full Text Available Abstract In recent years many efforts of researchers and clinicians were made to improve our knowledge of cachexia syndrome. Not only cancer, but also many chronic or end-stage diseases such as AIDS, chronic obstructive pulmonary disease (COPD, rheumatoid arthritis, tuberculosis and Crohn's disease are associated with cachexia, a condition of abnormally low weight, weakness, and general bodily decline which deteriorates quality of life and reduces the prognosis of the patients who suffer from it. In the present editorial we will focus cachexia related on cancer and provide some insight into this prognosis-limiting syndrome.

  11. [Cervix cancer].

    Science.gov (United States)

    Pointreau, Y; Ruffier Loubière, A; Denis, F; Barillot, I

    2010-11-01

    Cervix cancers declined in most developed countries in recent years, but remain, the third worldwide leading cause of cancer death in women. A precise staging, based on clinical exam, an abdominal and pelvic MRI, a possible PET-CT and a possible lymph node sampling is necessary to adapt the best therapeutic strategy. In France, the treatments of tumors of less than 4 cm without nodal involvement are often based on radiotherapy followed by surgery and, whereas tumors larger than 4 cm and involved nodes are treated with concurrent chemoradiotherapy. Based on an illustrated clinical case, indications, delineation, dosimetry and complications expected with radiotherapy are demonstrated.

  12. Penile Cancer

    Science.gov (United States)

    Clark, Peter E.; Spiess, Philippe E.; Agarwal, Neeraj; Biagioli, Matthew C.; Eisenberger, Mario A.; Greenberg, Richard E.; Herr, Harry W.; Inman, Brant A.; Kuban, Deborah A.; Kuzel, Timothy M.; Lele, Subodh M.; Michalski, Jeff; Pagliaro, Lance; Pal, Sumanta K.; Patterson, Anthony; Plimack, Elizabeth R.; Pohar, Kamal S.; Porter, Michael P.; Richie, Jerome P.; Sexton, Wade J.; Shipley, William U.; Small, Eric J.; Trump, Donald L.; Wile, Geoffrey; Wilson, Timothy G.; Dwyer, Mary; Ho, Maria

    2014-01-01

    Squamous cell carcinoma of the penis represents approximately 0.5% of all cancers among men in the United States and other developed countries. Although rare, it is associated with significant disfigurement, and only half of the patients survive beyond 5 years. Proper evaluation of both the primary lesion and lymph nodes is critical, because nodal involvement is the most important factor of survival. The NCCN Clinical Practice Guidelines in Oncology for Penile Cancer provide recommendations on the diagnosis and management of this devastating disease based on evidence and expert consensus. PMID:23667209

  13. Aromatase Inhibitors and Other Compounds for Lowering Breast Cancer Risk

    Science.gov (United States)

    ... Cancer? Breast Cancer Colon/Rectum Cancer Lung Cancer Prostate Cancer Skin Cancer Show All Cancer Types News and Features Cancer Glossary ACS Bookstore Cancer Information Cancer Basics Cancer Prevention & Detection Signs & Symptoms of Cancer Treatments & Side Effects ...

  14. Cancer Data and Statistics Tools

    Science.gov (United States)

    ... in Cancer Moonshot Stay Informed Cancer Data and Statistics Tools Recommend on Facebook Tweet Share Compartir United States Cancer Statistics The United States Cancer Statistics (USCS): Incidence and ...

  15. Esophageal cancer

    DEFF Research Database (Denmark)

    Mortensen, M. B.

    2007-01-01

    The distribution of adenocarcinomas and squamous cell carcinomas in esophageal cancer (EC) has changed, and focus directed towards tumors of the distal esophagus and the esophagogastric junction. The genetic events leading to EC are not fully clarified, but important risk factors have been...

  16. Lung cancer

    DEFF Research Database (Denmark)

    Hansen, H H; Rørth, M

    1999-01-01

    The results of the many clinical trials published in 1997 had only modest impact on the treatment results using either cytostatic agents alone or combined with radiotherapy in lung cancer. In SCLC, combination chemotherapy including platin-compounds (cisplatin, carboplatin) and the podophyllotoxins...

  17. Colon Cancer

    Centers for Disease Control (CDC) Podcasts

    2013-11-05

    In this podcast, Dr. Tom Frieden, CDC Director, discusses colon cancer and the importance of early detection.  Created: 11/5/2013 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 3/6/2014.

  18. Lung cancer

    International Nuclear Information System (INIS)

    This article is about the diagnosis, treatment and monitoring of lung cancer. Before the treatment the histological samples allowing the diagnosis as well as its histological variety. The diagnosis include techniques such as bronchoscopy, ultrasound, tomography, puncture and endoscopic thoracotomy. The chemotherapy and radiotherapy are the main techniques used for the treatment

  19. Kidney Cancer

    Science.gov (United States)

    You have two kidneys. They are fist-sized organs on either side of your backbone above your waist. The tubes inside filter and ... blood, taking out waste products and making urine. Kidney cancer forms in the lining of tiny tubes ...

  20. Oropharyngeal Cancer

    International Nuclear Information System (INIS)

    Cancers of the oropharynx are common lesions. Their treatment often includes radiation therapy either exclusively or in combination with chemotherapy or after surgery. The definition of target volumes is made difficult by the complex anatomy of this area. The aim of this work is to clarify the principles of 3D conformal radiation illustrated by a case report. (authors)

  1. Prostate cancer is not breast cancer

    Directory of Open Access Journals (Sweden)

    Ajit Venniyoor

    2016-01-01

    Full Text Available Cancers of the prostate and breast are hormone dependent cancers. There is a tendency to equate them and apply same algorithms for treatment. It is pointed out that metastatic prostate cancer with bone-only disease is a potentially fatal condition with a much poorer prognosis than metastatic breast cancer and needs a more aggressive approach.

  2. Cancer Stem Cells in Pancreatic Cancer

    International Nuclear Information System (INIS)

    Pancreatic cancer is an aggressive malignant solid tumor well-known by early metastasis, local invasion, resistance to standard chemo- and radiotherapy and poor prognosis. Increasing evidence indicates that pancreatic cancer is initiated and propagated by cancer stem cells (CSCs). Here we review the current research results regarding CSCs in pancreatic cancer and discuss the different markers identifying pancreatic CSCs. This review will focus on metastasis, microRNA regulation and anti-CSC therapy in pancreatic cancer

  3. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Diagnosis Staging Prognosis Treatment Types of Treatment Side Effects Clinical Trials Cancer Drugs Complementary & Alternative Medicine Coping Feelings & Cancer Adjusting to Cancer Self Image & Sexuality Day to Day Life Survivorship For Family & Friends Questions to Ask About Cancer Advanced Cancer ...

  4. Prostate Cancer Research Trial Helps John Spencer Treat His Cancer

    Science.gov (United States)

    ... this page please turn Javascript on. Feature: Prostate Cancer Prostate Cancer Research Trial Helps John Spencer Treat His ... Read More "Prostate Cancer" Articles Progress Against Prostate Cancer / Prostate Cancer Research Trial Helps John Spencer Treat His ...

  5. How childhood cancers are different from adult cancers

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/patientinstructions/000845.htm How childhood cancers are different from adult cancers To use ... children with cancer can be cured. Types of Childhood Cancers Cancer in children is rare, but some ...

  6. Identifying cancer genes from cancer mutation profiles by cancer functions

    Institute of Scientific and Technical Information of China (English)

    LI YanHui; GUO Zheng; PENG ChunFang; LIU Qing; MA WenCai; WANG Jing; YAO Chen; ZHANG Min; ZHU Jing

    2008-01-01

    It is of great importance to identify new cancer genes from the data of large scale genome screenings of gene mutations in cancers. Considering the alternations of some essential functions are indispensable for oncogenesis, we define them as cancer functions and select, as their approximations, a group of detailed functions in GO (Gene Ontology) highly enriched with known cancer genes. To evaluate the efficiency of using cancer functions as features to identify cancer genes, we define, in the screened genes, the known protein kinase cancer genes as gold standard positives and the other kinase genes as gold standard negatives. The results show that cancer associated functions are more efficient in identifying cancer genes than the selection pressure feature. Furthermore, combining cancer functions with the number of non-silent mutations can generate more reliable positive predictions. Finally, with precision 0.42, we suggest a list of 46 kinase genes as candidate cancer genes which are annotated to cancer functions and carry at least 3 non-silent mutations.

  7. NCI Designated Cancer Centers

    Science.gov (United States)

    ... content 1-800-4-CANCER Live Chat Publications Dictionary Menu Contact Dictionary Search About Cancer Causes and Prevention Risk Factors ... Contacts Other Funding Find NCI funding for small business innovation, technology transfer, and contracts Training Cancer Training ...

  8. Cancer Genetics Services Directory

    Science.gov (United States)

    ... content 1-800-4-CANCER Live Chat Publications Dictionary Menu Contact Dictionary Search About Cancer Causes and Prevention Risk Factors ... Contacts Other Funding Find NCI funding for small business innovation, technology transfer, and contracts Training Cancer Training ...

  9. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... side effects from the cancer treatments you received. Video Series This video series offers the perspectives of ... care teams (PDF-210KB). Understanding Your Cancer Prognosis Video View this video on YouTube. Three cancer patients ...

  10. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Overview Cancer Screening Overview–for health professionals Screening Tests Research Diagnosis and Staging Symptoms Diagnosis Staging Prognosis ... Cancer Prevention Overview Screening Cancer Screening Overview Screening Tests Diagnosis & Staging Symptoms Diagnosis Staging Prognosis Treatment Types ...

  11. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... and Caregivers A to Z List of Cancer Drugs Complementary & Alternative Medicine (CAM) Questions to Ask about Your Treatment Research ... Types of Treatment Side Effects Clinical Trials Cancer Drugs Complementary & Alternative Medicine Coping Feelings & Cancer Adjusting to ...

  12. Esophagus Cancer: Palliative Therapy

    Science.gov (United States)

    ... in our document Guide to Controlling Cancer Pain . Nutritional support Nutrition is another concern for many patients with esophagus cancer. The cancer or its treatment might affect how you swallow ... supplements and information about your individual nutritional needs. ...

  13. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Self Image & Sexuality Day-to-Day Life For Family & Friends Survivorship Questions to Ask About Cancer Research ... Image & Sexuality Day to Day Life Survivorship For Family & Friends Questions to Ask About Cancer Advanced Cancer ...

  14. Liver cancer - hepatocellular carcinoma

    Science.gov (United States)

    Primary liver cell carcinoma; Tumor - liver; Cancer - liver; Hepatoma ... Hepatocellular carcinoma accounts for most liver cancers. This type of cancer occurs more often in men than women. It is usually diagnosed in people age 50 or older. ...

  15. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... research about a specific cancer type Progress Annual Report to the Nation Cancer Portfolio Snapshots Milestones in Cancer Research & Discovery Stories of Discovery Grants & Training Research Grants Funding Opportunities Funding Strategy Research Program ...

  16. Oral Cancer Exam

    Medline Plus

    Full Text Available ... oral cancer. For Patients and the Public Oral Cancer Pamphlet that describes the risk factors, signs and symptoms of oral cancer, and the importance of detecting the disease in ...

  17. What Is Vaginal Cancer?

    Science.gov (United States)

    ... of the uterus) to open up at the vulva (the external female genitals). The vagina is lined ... cancer. Likewise, if the cancer involves both the vulva and the vagina, it’s considered a vulvar cancer. ...

  18. Squamous cell skin cancer

    Science.gov (United States)

    ... earliest form of squamous cell cancer is called Bowen disease (or squamous cell carcinoma in situ). This type ... cancer; Squamous cell carcinoma of the skin Images Bowen's disease on the hand Keratoacanthoma Keratoacanthoma Skin cancer, squamous ...

  19. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... and Caregivers A to Z List of Cancer Drugs Complementary & Alternative Medicine (CAM) Questions to Ask about ... Types of Treatment Side Effects Clinical Trials Cancer Drugs Complementary & Alternative Medicine Coping Feelings & Cancer Adjusting to ...

  20. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Series This video series offers the perspectives of three cancer patients and their doctor. The videos explain ... Cancer Prognosis Video View this video on YouTube. Three cancer patients and their doctor, Anthony L. Back, ...

  1. What Is Stomach Cancer?

    Science.gov (United States)

    ... the key statistics about stomach cancer? What is stomach cancer? Cancer starts when cells in the body ... normal structure and function of the stomach. The stomach After food is chewed and swallowed, it enters ...

  2. Snapshot of Stomach Cancer

    Science.gov (United States)

    ... and Discovery Stories of Discovery A Snapshot of Stomach Cancer Incidence and Mortality Stomach (gastric) cancer is ... at the SEER Web site. NCI’s Investment in Stomach Cancer Research To learn more about the research ...

  3. Breast cancer screenings

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000837.htm Breast cancer screenings To use the sharing features on this page, please enable JavaScript. Breast cancer screenings can help find breast cancer early, before ...

  4. Prostate cancer screenings

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000846.htm Prostate cancer screenings To use the sharing features on this ... Intern Med . 2011;155(11):762-71. National Cancer Institute. Prostate Cancer Screening -- for health professionals. Revised April 2, ...

  5. What Is Prostate Cancer?

    Medline Plus

    Full Text Available ... no such thing as one type of prostate cancer. Prostate cancer is really a spectrum of diseases where on ... very benevolent in its behavior. Men will develop prostate cancer and live the rest of their lives -- 20, ...

  6. Cancer Genetics Services Directory

    Science.gov (United States)

    ... Prevention Overview–for health professionals Research NCI Cancer Genetics Services Directory This directory lists professionals who provide services related to cancer genetics (cancer risk assessment, genetic counseling, genetic susceptibility testing, ...

  7. CancerCare

    Science.gov (United States)

    ... Learn more A cancer diagnosis turns a person’s world upside down — emotionally, physically and financially. Cancer Care ® ... Caregiving When Your Loved One Has Triple Negative Breast Cancer Connect Education Workshop Reiki Community Program Oct 27 ...

  8. Male Breast Cancer

    Science.gov (United States)

    Although breast cancer is much more common in women, men can get it too. It happens most often to men between ... 60 and 70. Breast lumps usually aren't cancer. However, most men with breast cancer have lumps. ...

  9. What Is Pancreatic Cancer?

    Science.gov (United States)

    ... very important to distinguish between exocrine and endocrine cancers of the pancreas. They have distinct risk factors and causes, have ... are by far the most common type of pancreas cancer. If you are told you have pancreatic cancer, ...

  10. Bladder Cancer Advocacy Network

    Science.gov (United States)

    ... future bladder cancer research through the Patient Survey Network. Read More... The JPB Foundation 2016 Bladder Cancer ... 2016 Young Investigator Awardees The Bladder Cancer Advocacy Network (BCAN) has announced the recipients of the 2016 ...

  11. Cervical Cancer Screening

    Science.gov (United States)

    ... Cancer found early may be easier to treat. Cervical cancer screening is usually part of a woman's health ... may do more tests, such as a biopsy. Cervical cancer screening has risks. The results can sometimes be ...

  12. Skin Cancer Trends

    Science.gov (United States)

    ... Search The CDC Cancel Submit Search The CDC Skin Cancer Note: Javascript is disabled or is not supported ... Cervical Colorectal (Colon) Lung Ovarian Prostate Cancer Home Skin Cancer Trends Language: English Español (Spanish) Recommend on Facebook ...

  13. Prostate Cancer Foundation

    Science.gov (United States)

    ... P 2 rovocative Questions PCCTC Scientific Retreat Coffey-Holden Research News Faces of Prostate Cancer [4] Survivors ... Foundation News The Prostate Cancer Foundation’s 2016 Coffey-Holden Prostate Cancer Academy Meeting accelerates advances in the ...

  14. Prostate Cancer Screening

    Science.gov (United States)

    ... man's bladder that produces fluid for semen. Cancer screening is looking for cancer before you have any ... be easier to treat. There is no standard screening test for prostate cancer. Researchers are studying different ...

  15. Oral Cancer Exam

    Medline Plus

    Full Text Available ... Tips Careers & Training Fellowships and Internships for... High School and College Students Recent College Graduates Dental and ... Oral Cancer > Oral Cancer Exam Video Oral Cancer Exam Video This video shows what happens during an ...

  16. 1985 Cancer Facts and Figures.

    Science.gov (United States)

    American Cancer Society, Inc., New York, NY.

    Information and statistical data about cancer are provided in seven categories. They include: (1) basic cancer data (considering how cancer works, trends in diagnosis and treatment, new cancer cases and deaths for 1985, and other areas); (2) major cancer sites (discussing lung cancer, colorectal cancer, breast cancer, 5-year survival rates/trends…

  17. Biological Therapy in Treating Patients With Metastatic Cancer

    Science.gov (United States)

    2013-02-21

    Breast Cancer; Colorectal Cancer; Extrahepatic Bile Duct Cancer; Gallbladder Cancer; Gastric Cancer; Head and Neck Cancer; Liver Cancer; Lung Cancer; Metastatic Cancer; Ovarian Cancer; Pancreatic Cancer; Testicular Germ Cell Tumor

  18. Safe practice of cosmetic dermatology: Avoiding legal tangles

    Directory of Open Access Journals (Sweden)

    Sarvajnamurthy A Sacchidanand

    2012-01-01

    Full Text Available The present day dermatologists, in addition to conventional skin physicians, are also dermatologic-surgeons and cosmetologists in their practice. The cosmetic procedures have the inherent risk of malpractice litigations leaving an unsatisfied patient and a troublesome lawsuit against the doctor. A MEDLINE search was conducted for article with words such as legal issues and dermatology, malpractice in dermatology, safe practice of cosmetology etc. The selected articles are scrutinized and compiled so as to help the young dermatologists to have a comprehensive overview of safe cosmetology practice. This article aims at sensitizing the young dermatologists for the possible complications and provides an overview of safe practice. It also provides a list of simple routine precautions which helps the dermatologist to avoid unnecessary trips to the courthouse.

  19. Growing against ourselves; the energy-environment tangle

    International Nuclear Information System (INIS)

    After the first section which describes problems encountered in dealing with energy and the environment, the second section of this book presents technical problems such as electrical energy supply and demand, cooling problems, air pollution, and their biological and environmental effects, specificly regarding nuclear power production. Further, energy policies of the United States, the United Kingdom, France and Poland are reviewed containing comparative evaluations of different energy sources, among which nuclear power and fossile fuel plants are included. Future strategies and approaches are discussed in part three where LMFBR plants, fission energy and solar energy are reviewed as alternatives for future energy production and a proposal is made to use system analysis in environmental control

  20. Current Sheets Formation in Tangled Coronal Magnetic Fields

    CERN Document Server

    Rappazzo, A F

    2013-01-01

    We investigate the dynamical evolution of magnetic fields in closed regions of solar and stellar coronae. To understand under which conditions current sheets form, we examine dissipative and ideal reduced magnetohydrodynamic models in cartesian geometry, where two magnetic field components are present: the strong guide field $B_0$, extended along the axial direction, and the dynamical orthogonal field $\\mathbf{b}$. Magnetic field lines thread the system along the axial direction, that spans the length $L$, and are line-tied at the top and bottom plates. The magnetic field $b$ initially has only large scales, with its gradient (current) length-scale of order $\\ell_b$. We identify the magnetic intensity threshold $b/B_0 \\sim \\ell_b/L$. For values of $b$ below this threshold, field-line tension inhibits the formation of current sheets, while above the threshold they form quickly on fast ideal timescales. In the ideal case, above the magnetic threshold, we show that current sheets thickness decreases in time unti...

  1. Safe Practice of Cosmetic Dermatology: Avoiding Legal Tangles

    OpenAIRE

    Sarvajnamurthy A Sacchidanand; Shilpa Bhat

    2012-01-01

    The present day dermatologists, in addition to conventional skin physicians, are also dermatologic-surgeons and cosmetologists in their practice. The cosmetic procedures have the inherent risk of malpractice litigations leaving an unsatisfied patient and a troublesome lawsuit against the doctor. A MEDLINE search was conducted for article with words such as legal issues and dermatology, malpractice in dermatology, safe practice of cosmetology etc. The selected articles are scrutinized and comp...

  2. Conservation through community: An attempt to untangle a tangled word.

    Directory of Open Access Journals (Sweden)

    Deeraj Koul

    2014-04-01

    Full Text Available Conservation is not something that can be thrust upon a community, and neither can it be labelled as a measure to take away a people’s rights and nor can it be used as a force to make others adhere to rules and laws from outside; by outside I mean you and me and your or my Government. I am not writing to highlight that conservation should not happen with the community but I do believe that older community bonds are broken or they have started to brake and the ways implied earlier no longer hold in the field. Most of us are still hanging on to older approaches to community conservation but the younger generation in a community has moved beyond, now it is rare to see a community come together for the sake of collective benefits and also when conservation measures take longer to deliver the fruits and the sustained release of impacts over a period of time it makes people forget the changes made to the immediate environment, except for a few visible ones. This too is forgotten with time until the cycle of destruction repeats itself. Previously, the community used to look at water, forests and other natural resources as common resources and they used to protect them, but the present generation does not understand common resources. In their terms it has to be yours or mine or else it is the Government’s. There is no fourth dimension, i.e. the common resource which used to be a main dimension of conservation. The vanishing concept of the common resource has brought about the biggest destruction ever. New ways of conservation have to be found as older traditional ways of conservation may still work in some places but they will be not adhered to by the majority. I am not saying this because community led work isn’t good enough, but because the community system was previously woven into social fabric and there was mutual dependence. However, the social fabric has changed a lot over recent years and so has traditional community bonding. The west lost it a long time ago but other regions are catching up very quickly; community bonds are getting weaker and weaker and other ways of social bonding are taking over and we all are still struggling to solve problems through our narrow prism of community. We need to broaden it. I don’t mean that community shouldn’t be involved, it is the only way, but we need to understand the psyche of the community and try new ways to involve it. I hope I have not confused you and that you will continue reading. For everyone the mantra of conservation is through community and almost all conservation activities revolve around one particular community. However, I feel there is a problem with the way it is projected and the percentage success rate is very low. In other words, in a world were two brothers do not have same level of thinking and the same approach to a single issue, how can we expect a community to work together on a single focused agenda and hold on to it for a long period at a time when people have started to weigh everything on a scale of personal gain. Also, since conservation is a time-consuming process it is quite likely that the efforts of a community and its initial enthusiasm will fade over time. On this point a lot of people will try to pounce on me and try to prove me wrong with data and by showcasing successful community level projects. I do not deny that there are lots of success stories but are we getting the percentage of results that should have been achieved by now with so many NGOs, aid agencies and government efforts coming together? What is the success rate of these projects? An officer from the forest department once told me that in the last 30 years in India so many plantations have been made through community that no space would be available for plantations if all the work had born results. He may have exaggerated or he may be referring to poor implementation but there might still be some truth to his word. Also, I do expect the same kind of results around the world with some variations, since so much money has been spent through reforestation, community forestry. There seems to be a huge difference in conservation through community available on paper records and the reality on the ground, meaning that no matter how much money is spent, conservation has a low success rate and we are still persisting with ideas that have a very low percentage of success. In a community project a lot of management committees are formed, a forest committee, a watershed committee, a management committee; people participate and committees are formed but most of the committees become defunct over a period of time or they remain but are inactive. What are the reasons behind this? Maybe there is very little personal stake or low interest due to the high probability of getting bad reputation in the eyes of people if a community member tries to ensure that the system is adhered to. As the needs of people are unlimited and resources are limited a conflict of interest is bound to arise. I agree that other factors such as local politics etc. are also responsible, and I also agree that we need to persist in conservation through community as any other option will be suicidal. Some will try to argue that for any project the work to be undertaken is decided by the community and even the priority of work is decided by the community, at each step the community is involved from initiation to completion. But how many of us see sustained community support and adherence from initiation to completion and beyond. As we know from the human tendency most times we humans get involved keenly only when we see direct benefits, and not through indirect benefits or co-benefits. Thus, in order to make everyone get involved each person has to see some kind of a personal stake in the project, otherwise only a few will persist and others will not. We as conservationists think that it is the duty of a community to protect itself. Conservation will not be successful because we think that the community should protect itself. Even within a community there are different views and they will come together but will only disintegrate with time. To see how well a project will work I believe that we first need to analyse how much the members of the community are dependent on each other, how much the community is woven into the social fabric and its bonds, how much the community is not affected by my political factionalism. And if the community lacks in the above then we have to change the way conservation is conducted. Community approaches like collective thinking but direct individual benefits need to be incorporated more into the programmes so that better results can be achieved, by direct benefit I don’t mean monetary benefit but giving every individual a sense of belief that whatever conservation effort he has done at his level is his own, it is his creation and he is the master of its destiny. I also trust that we are witnessing new social bonding’s which are independent of regional background, politics, colour, rich and poor differentiation, taking shape and blooming as social media groups, they have a power to evolve a new thinking, bring change and develop a new form of common resource concept which can take conservation of globalised community to a new platform. These are not the only ways but surely other ways of uniting a community need to be found in order to generate a truly participatory approach.

  3. The Tangled Web of Taliban and Associated Movements

    Directory of Open Access Journals (Sweden)

    Greg Smith

    2009-01-01

    Full Text Available Following the devastating terrorist attacks of September 11, 2001,worldwide attention became focused on the Taliban and al-Qaida forcesin Afghanistan. Prior to the attacks, many people had never heard of the Taliban or their shar'ia-law style of government. Since 2001, manysplinter groups have formed in response to the continual United Statespresence in the region. Today, the term Taliban has been used to envelop several groups such as the Tehrik-i-Taliban Pakistan (TTP, the Haqqani Network (HQN and the Tehrik-eNifaz-e-Shariat-e-Mohammadi(TNSM. These groups make up the majority of fighters along the Afghanistan-Pakistan border. Many of these groups have been historicrivals for control of the region, but have since joined a loose alliance in response to United States and Pakistani Government actions in the Federally Administered Tribal Areas (FATA. This article examines the origins and operations of the Pakistani Taliban and associated groups. Particular attention will be given as to how these groups receive funding and support from each other through state sponsors such as Pakistan's Inter-Services Intelligence (ISI agency and non-state sponsors such as al-Qaida and Wahhabi idealists in Saudi Arabia, as well as arms supplies from Iran and potentially China.

  4. Aging and Neurodegeneration: A Tangle of Models and Mechanisms

    Science.gov (United States)

    Chakrabarti, Sasanka; Mohanakumar, Kochupurackal P.

    2016-01-01

    The research on aging and age-related diseases, especially the neurodegenerative diseases, is on the fast track. However, the results have so far not been translated to actual benefit for the patients in terms of treatment or diagnosis of age-related degenerative diseases including those of the CNS. As far as the prevention of the cognitive decline during non-pathological aging is concerned, there is nothing much to offer other than calorie restriction and physical exercise. Needless to say, the benefits are not up to our expectations. However, over the years at the experimental level it has been possible to identify several cellular and molecular mechanisms that are intricately associated with aging in general and neurodegenerative diseases in particular. These include oxidative stress and altered redox-signaling, mitochondrial dysfunction, inflammation, proteotoxicity and altered gene expressions. These inter-dependent pathways mediate cellular senescence and often culminate in programmed cell death like apoptosis and autophagy, and in the context of brain these changes are manifested clinically as cognitive decline and pathologically as neurodegeneration. This special issue provides the readers with glimpses of this complex scenario from different angles primarily in the context of brain and also attempts to identify the potential drug targets against neurodegenerative diseases. PMID:27114843

  5. A FORAY INTO THE TANGLE OF GLOBALIZATION MEASUREMENT

    Directory of Open Access Journals (Sweden)

    PhD Iulia LUPU

    2013-06-01

    Full Text Available The concerns over globalization and its impact on the different aspects of life amplified over the recent years and generated the need to measure this phenomenon so as to know its effects and to get prepared to manage them. This paper makes a critical presentation of the main indicators that measure the phenomenon of globalization and selected one indicator, seemingly the most comprehensive, and applied it to Romania in order to see its rank when comparing with other countries, according to the values of the indicator and its components.

  6. Living with Cancer

    Institute of Scientific and Technical Information of China (English)

    1996-01-01

    Cancer is regarded as a formidable threat to mankind. Every yem’ in Shanghai, which has a high cancer rate, 15,000 people are diagnosed with the disease and 12,000 die of cancer. Because many people believe that "cancer equals death," a special cancer rehabilitation center has appeared in Shanghai. The center creates an environment where cancer patients can exchange experiences and receive psychological group therapy. In this way those patients

  7. What Is Melanoma Skin Cancer?

    Science.gov (United States)

    ... statistics for melanoma skin cancer What is melanoma skin cancer? Cancer starts when cells in the body begin ... causing the skin to tan or darken. Melanoma skin cancers Melanoma is a cancer that begins in the ...

  8. Risks of Skin Cancer Screening

    Science.gov (United States)

    ... Genetics of Skin Cancer Skin Cancer Screening Research Skin Cancer Screening (PDQ®)–Patient Version What is screening? Go ... These are called diagnostic tests . General Information About Skin Cancer Key Points Skin cancer is a disease in ...

  9. Types of Cancer Research

    Science.gov (United States)

    An infographic from the National Cancer Institute (NCI) describing the four broad categories of cancer research: basic research, clinical research, population-based research, and translational research.

  10. Find a Cancer Doctor

    Science.gov (United States)

    ... Biostatistics/Epidemiology Developmental Therapeutics Endocrine Tumors Gastroenterology Gastrointestinal Cancer (not Liver & Pancreas) General Oncology Genetics/Gene Therapy Genitourinary Cancer Geriatrics ...

  11. Global cancer statistics, 2012.

    Science.gov (United States)

    Torre, Lindsey A; Bray, Freddie; Siegel, Rebecca L; Ferlay, Jacques; Lortet-Tieulent, Joannie; Jemal, Ahmedin

    2015-03-01

    Cancer constitutes an enormous burden on society in more and less economically developed countries alike. The occurrence of cancer is increasing because of the growth and aging of the population, as well as an increasing prevalence of established risk factors such as smoking, overweight, physical inactivity, and changing reproductive patterns associated with urbanization and economic development. Based on GLOBOCAN estimates, about 14.1 million new cancer cases and 8.2 million deaths occurred in 2012 worldwide. Over the years, the burden has shifted to less developed countries, which currently account for about 57% of cases and 65% of cancer deaths worldwide. Lung cancer is the leading cause of cancer death among males in both more and less developed countries, and has surpassed breast cancer as the leading cause of cancer death among females in more developed countries; breast cancer remains the leading cause of cancer death among females in less developed countries. Other leading causes of cancer death in more developed countries include colorectal cancer among males and females and prostate cancer among males. In less developed countries, liver and stomach cancer among males and cervical cancer among females are also leading causes of cancer death. Although incidence rates for all cancers combined are nearly twice as high in more developed than in less developed countries in both males and females, mortality rates are only 8% to 15% higher in more developed countries. This disparity reflects regional differences in the mix of cancers, which is affected by risk factors and detection practices, and/or the availability of treatment. Risk factors associated with the leading causes of cancer death include tobacco use (lung, colorectal, stomach, and liver cancer), overweight/obesity and physical inactivity (breast and colorectal cancer), and infection (liver, stomach, and cervical cancer). A substantial portion of cancer cases and deaths could be prevented by broadly

  12. Cancer Statistics: Cancer of the Small Intestine

    Science.gov (United States)

    ... party. HPF: SEER Stat Fact Sheets: Small Intestine Cancer Expand All Collapse All Lifetime risk estimates are ... Or More after Being Diagnosed with Small Intestine Cancer? Relative survival statistics compare the survival of patients ...

  13. Cancer Statistics: Cancer of the Stomach

    Science.gov (United States)

    ... third party. HPF: SEER Stat Fact Sheets: Stomach Cancer Expand All Collapse All Lifetime risk estimates are ... Years Or More after Being Diagnosed with Stomach Cancer? Relative survival statistics compare the survival of patients ...

  14. Cancer Statistics: Cancer of the Vulva

    Science.gov (United States)

    ... third party. HPF: SEER Stat Fact Sheets: Vulvar Cancer Expand All Collapse All Lifetime risk estimates are ... Years Or More after Being Diagnosed with Vulvar Cancer? Relative survival statistics compare the survival of patients ...

  15. [Thyroid cancer].

    Science.gov (United States)

    Nagayama, Yuji

    2012-03-01

    The thyroid glands are a vulnerable organ to ionizing radiation. Indeed the epidemiological studies have revealed an increase in the incidences of thyroid cancer among atomic bomb survivors in Hiroshima and Nagasaki and radiation casualties in Chernobyl. The carcinogenic risk for the thyroids is dependent on radiation dose, and higher in younger people. Recent advances in molecular biology contribute to clarify the mechanisms for thyroid carcinogenesis at genetic and molecular levels. Here radiation-induced thyroid carcinogenesis is reviewed from epidemiological data to basic research. PMID:22514922

  16. Cancer Stem Cells in Pancreatic Cancer

    OpenAIRE

    Karl-Walter Jauch; Hendrik Seeliger; Hanno Niess; Qi Bao; Andrea Renner; Yue Zhao; Bruns, Christiane J.

    2010-01-01

    Pancreatic cancer is an aggressive malignant solid tumor well-known by early metastasis, local invasion, resistance to standard chemo- and radiotherapy and poor prognosis. Increasing evidence indicates that pancreatic cancer is initiated and propagated by cancer stem cells (CSCs). Here we review the current research results regarding CSCs in pancreatic cancer and discuss the different markers identifying pancreatic CSCs. This review will focus on metastasis, microRNA regulation and anti-CSC t...

  17. Cancer stem cells in prostate cancer

    OpenAIRE

    Moltzahn, Felix; Thalmann, George N

    2013-01-01

    Prostate cancer (P-Ca) remains a leading cause of cancer-related death in men. Lately, increasing evidence for a hierarchically organized cancer stem cell (CSC) model emerged for different tumors entities, including P-Ca. CSCs are defined by several characteristics including self-renewal, pluripotency and tumorigenicity and are thought to be responsible for tumor recurrence, metastasis and cancer related death. In this review we discuss the recent research in the field of CSCs, its limitation...

  18. [The Dutch Cancer Society Cancer Risk Test].

    NARCIS (Netherlands)

    Elias, S.; Grooters, H.G.; Bausch-Goldbohm, R.A.; Brandt, P.A. van den; Kampman, E.; Leeuwen, F.E. van; Peeters, P.H.M.; Vries, E. de; Wigger, S.; Kiemeney, L.A.L.M.

    2012-01-01

    The Dutch Cancer Society developed the 'KWF Kanker Risico Test' (Cancer Risk Test) to improve the information available to the Dutch population regarding cancer risk factors. This Internet test, based under licence on the American 'Your Disease Risk' test, informs users about risk factors for 12 com

  19. 国民党新军阀混战与工农武装割据--以井冈山和中央革命根据地的成功开创为例%Tangled Warfare among the KMT New Warlords and the Armed IndePendent Regimes of Workers and Peasants---For An ExamPle of the Successful Creation of the Jinggangshan and Central Revolutionary Bases

    Institute of Scientific and Technical Information of China (English)

    黄少群

    2014-01-01

    Mao Zedong once pointed out that,“the long - term split and warfare among white regimes provided a condition which made it possible that a small piece or some pieces of red areas under the CPC’s leadership came into being and survived in the surrounding of white regimes. ”This paper,taking examples of the success-ful creation of the Jinggangshan and Central Revolutionary Bases,elaborates the development process of the armed independent regimes of workers and peasants,i. e. ,the Red Army and rural revolutionary bases,led by Chinese communists represented by Mao Zedong and Zhu De in the clearances of tangled warfare among the KMT new warlords around the 1930s. The realization of armed independent regimes based on the tangled warfare of the KMT new warlords embodies the CPC leaders’strategic thinking of seeking for proper development oppor-tunities.%毛泽东曾指出:“因为有了白色政权间的长期的分裂和战争,便给了一种条件,使一小块或若干小块的共产党领导的红色区域,能够在四围白色政权包围的中间发生和坚持下来。”本文以井冈山和中央革命根据地的成功开创为例,阐述在上世纪30年代前后的国民党新军阀混战的空隙中,中国共产党通过以毛泽东、朱德为代表领导的工农武装割据,实现红军和农村革命根据地发展壮大的历程。借国民党新军阀混战之机实现工农武装割据,体现了中国共产党领导人审时度势寻找发展机遇的高超战略思维。

  20. Biologic Therapy (Immunotherapy) for Kidney Cancer

    Science.gov (United States)

    ... for kidney cancer Targeted therapies for kidney cancer Biologic therapy (immunotherapy) for kidney cancer Chemotherapy for kidney cancer Pain control for kidney cancer Treatment choices by stage for ...

  1. Report: Human cancer genetics

    Institute of Scientific and Technical Information of China (English)

    LI Marilyn; ALBERTSON Donna

    2006-01-01

    The short report will be focused on the genetic basis and possible mechanisms of tumorigenesis, common types of cancer, the importance of genetic diagnosis of cancer, and the methodology of cancer genetic diagnosis. They will also review presymptomatic testing of hereditary cancers, and the application of expression profiling to identify patients likely to benefit from particular therapeutic approaches.

  2. | Division of Cancer Prevention

    Science.gov (United States)

    The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

  3. Breast cancer in men

    Science.gov (United States)

    ... in situ-male; Intraductal carcinoma-male; Inflammatory breast cancer-male; Paget disease of the nipple-male; Breast cancer-male ... The cause of breast cancer is not clear. But there are risk ... breast cancer more likely in men: Exposure to radiation Higher ...

  4. [The Dutch Cancer Society Cancer Risk Test].

    Science.gov (United States)

    Elias, Sjoerd G; Grooters, Hilda G; Bausch-Goldbohm, R A Sandra; van den Brandt, Piet A; Kampman, Ellen; van Leeuwen, Flora E; Peeters, Petra H M; de Vries, Esther; Wigger, Stefan; Kiemeney, L A L M Bart

    2012-01-01

    The Dutch Cancer Society developed the 'KWF Kanker Risico Test' (Cancer Risk Test) to improve the information available to the Dutch population regarding cancer risk factors. This Internet test, based under licence on the American 'Your Disease Risk' test, informs users about risk factors for 12 common types of cancer. The test provides an estimate of individual risk of a specific type of cancer and gives specific lifestyle advice that could lower that risk. This paper describes the development of the test, how it works, and its strengths and limitations.

  5. Telomerers rolle i cancer

    DEFF Research Database (Denmark)

    Bendix, Laila; Kølvraa, Steen

    2010-01-01

    Telomeres are a double-edged sword when it comes to cancer. On one hand, telomeres limit the cells' ability to divide and thereby restrict the uninhibited growth seen in cancer. On the other hand, short telomeres can initiate the chromosome instability that characterizes cancer. Diseases...... with the combination of short telomeres and high cancer risk are seen, but until now the use of telomeres as predictors of cancer has, in general, been unsuccessful. Telomeres and telomerase play an important role in further cancer development. Researchers are trying to exploit this in the development of new cancer...

  6. Lung cancer after treatment for breast cancer.

    Science.gov (United States)

    Lorigan, Paul; Califano, Raffaele; Faivre-Finn, Corinne; Howell, Anthony; Thatcher, Nick

    2010-12-01

    Breast cancer is the most common cancer in women, and the second most common cause of cancer death after lung cancer. Improvements in the outcome of breast cancer mean that more patients are living longer and are, therefore, at risk of developing a second malignancy. The aim of this review is to present the current understanding of the risk of lung cancer arising in patients previously treated for early stage breast cancer. We review data on the effect of treatment factors (ie, surgery type, radiotherapy technique, and adjuvant chemotherapy) and patient factors (ie, age and smoking) on the risk of developing a subsequent lung cancer. The evidence suggests that older radiotherapy techniques were associated with a substantially increased risk of developing lung cancer in the ipsilateral lung, but there is no clear evidence of an increased risk with modern techniques. Smoking is an important risk factor, and increases the risk of lung cancer in those receiving radiotherapy. Adjuvant chemotherapy is not significantly associated with an increased risk. The risk of developing lung cancer increases with time elapsed since treatment, but any effect of age at treatment is unclear.

  7. Can Prostate Cancer Be Found Early?

    Science.gov (United States)

    ... Research Get Involved Find Local ACS Learn About Cancer » Prostate Cancer » Detailed Guide » Can prostate cancer be found ... and symptoms of prostate cancer Tests for prostate cancer Prostate cancer stages Survival rates for prostate cancer Previous ...

  8. What Are Oral Cavity and Oropharyngeal Cancers?

    Science.gov (United States)

    ... Research Get Involved Find Local ACS Learn About Cancer » Oral Cavity and Oropharyngeal Cancer » Detailed Guide » What are ... how cancers start and spread, see What Is Cancer? Oral cavity cancer, or just oral cancer, is cancer ...

  9. Cancer and tumour markers

    International Nuclear Information System (INIS)

    Cancer has been a major cause of death world wide and in Nigeria there are six commonest forms of manifestation of cancer known. Of these prostrate cancer is the highest with 16% occurrence of all known cancers according to a study by the Histopathology Department of the UCH. Many factors, amongst them dietary, environmental, lifestyle, age and sedentary work are possible causes. With the global rise in incidents, the IAEA initiated the Tumour Marker Project as a means of screening cancers in 15 African countries including Nigeria. In Nigeria, 4 groups of the commonest cancers have been chosen for screening. These are prostrate cancer, primary liver cancer, cancer of the GI tract and trophoblastic cancer

  10. Imaging male breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Doyle, S., E-mail: sdoyle2@nhs.net [Primrose Breast Care Unit, Derriford Hospital, Plymouth (United Kingdom); Steel, J.; Porter, G. [Primrose Breast Care Unit, Derriford Hospital, Plymouth (United Kingdom)

    2011-11-15

    Male breast cancer is rare, with some pathological and radiological differences from female breast cancer. There is less familiarity with the imaging appearances of male breast cancer, due to its rarity and the more variable use of preoperative imaging. This review will illustrate the commonest imaging appearances of male breast cancer, with emphasis on differences from female breast cancer and potential pitfalls in diagnosis, based on a 10 year experience in our institution.

  11. Human cancer databases (Review)

    OpenAIRE

    Pavlopoulou, Athanasia; Spandidos, Demetrios A.; Michalopoulos, Ioannis

    2014-01-01

    Cancer is one of the four major non-communicable diseases (NCD), responsible for ~14.6% of all human deaths. Currently, there are >100 different known types of cancer and >500 genes involved in cancer. Ongoing research efforts have been focused on cancer etiology and therapy. As a result, there is an exponential growth of cancer-associated data from diverse resources, such as scientific publications, genome-wide association studies, gene expression experiments, gene-gene or protein-protein in...

  12. Breast cancer stem cells

    OpenAIRE

    Owens, Thomas W.; Naylor, Matthew J.

    2013-01-01

    Cancer metastasis, resistance to therapies and disease recurrence are significant hurdles to successful treatment of breast cancer. Identifying mechanisms by which cancer spreads, survives treatment regimes and regenerates more aggressive tumors are critical to improving patient survival. Substantial evidence gathered over the last 10 years suggests that breast cancer progression and recurrence is supported by cancer stem cells (CSCs). Understanding how CSCs form and how they contribute to th...

  13. Chemoradiotherapy for lung cancer

    International Nuclear Information System (INIS)

    Lung cancer remains a disease associated with a poor prognosis. Chemoradiotherapy is performed for unresectable stage 3 non-small cell lung cancer (NSCLC) and inoperable limited-disease small cell lung cancer. In this lecture, chemoradiotherapy for lung cancer is outlined primary according to the 2014 edition of the Clinical Practice Guidelines for Lung Cancer, and also referring to molecular targeted drugs, radiation pneumonitis, and particle radiotherapy. (author)

  14. Pancreatic Cancer Early Detection Program

    Science.gov (United States)

    2014-07-30

    Pancreatic Cancer; Pancreas Cancer; Pancreatic Adenocarcinoma; Familial Pancreatic Cancer; BRCA 1/2; HNPCC; Lynch Syndrome; Hereditary Pancreatitis; FAMMM; Familial Atypical Multiple Mole Melanoma; Peutz Jeghers Syndrome

  15. Molecular mechanism of 7TM receptor activation--a global toggle switch model

    DEFF Research Database (Denmark)

    Schwartz, Thue W; Frimurer, Thomas M; Holst, Birgitte;

    2006-01-01

    the accumulated biophysical data supporting an outward rigid-body movement of the intracellular segments, as well as the recent data derived from activating metal ion sites and tethered ligands, which suggests an opposite, inward movement of the extracellular segments of the transmembrane helices. According...

  16. Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation

    DEFF Research Database (Denmark)

    Elling, Christian E; Frimurer, Thomas M; Gerlach, Lars-Ole;

    2006-01-01

    for monoamine binding in TM-III, was used as the starting point to engineer activating metal ion sites between the extracellular segments of the beta2-adrenergic receptor. Cu(II) and Zn(II) alone and in complex with aromatic chelators acted as potent (EC50 decreased to 0.5 microm) and efficacious agonists...... in sites constructed between positions III:08 (Asp or His), VI:16 (preferentially Cys), and/or VII:06 (preferentially Cys). In molecular models built over the backbone conformation of the inactive rhodopsin structure, the heavy atoms that coordinate the metal ion were located too far away from each other...... to form high affinity metal ion sites in both the bidentate and potential tridentate settings. This indicates that the residues involved in the main ligand-binding pocket will have to move closer to each other during receptor activation. On the basis of the distance constraints from these activating metal...

  17. A new prospect in cancer therapy: targeting cancer stem cells to eradicate cancer

    Institute of Scientific and Technical Information of China (English)

    Li-Sha Chen; An-Xin Wang; Bing Dong; Ke-Feng Pu; Li-Hua Yuan; Yi-Min Zhu

    2012-01-01

    According to the cancer stem cell theory,cancers can be initiated by cancer stem cells.This makes cancer stem cells prime targets for therapeutic intervention.Eradicating cancer stem cells by efficient targeting agents may have the potential to cure cancer.In this review,we summarize recent breakthroughs that have improved our understanding of cancer stem cells,and we discuss the therapeutic strategy of targeting cancer stem cells,a promising future direction for cancer stem cell research.

  18. A new prospect in cancer therapy: targeting cancer stem cells to eradicate cancer

    OpenAIRE

    Yi-Min Zhu; Li-Hua Yuan; Ke-Feng Pu; Bing Dong; An-Xin Wang; Li-Sha Chen

    2012-01-01

    According to the cancer stem cell theory, cancers can be initiated by cancer stem cells. This makes cancer stem cells prime targets for therapeutic intervention. Eradicating cancer stem cells by efficient targeting agents may have the potential to cure cancer. In this review, we summarize recent breakthroughs that have improved our understanding of cancer stem cells, and we discuss the therapeutic strategy of targeting cancer stem cells, a promising future direction for cancer stem cell resea...

  19. What are cancer registries

    Directory of Open Access Journals (Sweden)

    Miladinov-Mikov Marica

    2004-01-01

    Full Text Available Introduction Population-based cancer registries attempt to collect, process, analyze, store and interpret data on persons with cancer in a certain population (most frequently a geographical area. Hospital-based cancer registries register all cases in a given hospital, usually without knowledge of the background population; the emphasis is to serve the needs of the hospital administration, the hospital cancer program, and, above all, the individual patient. History of Cancer Registries Registration of persons suffering from cancer is a slow process. Around the year 1900, England and Germany demanded improvement of statistical investigation on spread of cancer in population in order to undertake etiological researches. The oldest example of a modern cancer registry is that in Hamburg. Today there are more than 200 population-based cancer registries, but they cover only 5% of the world population, mainly in developed countries of the world. Cancer registry of Vojvodina Cancer registry of Vojvodina was established in 1966; it is a member of International Agency for Research on Cancer (IARC and it is still the only cancer registry from our country whose data are cited in scientific monographs of IARC. The main purpose of cancer registries is to produce statistics on the occurrence of cancer in a defined populatin and to provide a framework for assessing and controlling the impact of cancer on the community. Cancer registries are essential parts of any rational program of cancer control. Their data can be used in a wide variety of areas of cancer control, ranging from etiological research in epidemiology, through primary and secondary prevention to health-care planning and patient care, so benefiting both the individual and society.

  20. American Cancer Society Recommendations for Prostate Cancer Early Detection

    Science.gov (United States)

    ... saved articles window. My Saved Articles » My ACS » Prostate Cancer Prevention and Early Detection + - Text Size Download Printable Version [ ... coverage for prostate cancer screening Additional resources for prostate cancer prevention and early detection References: Prostate cancer prevention and ...

  1. How Are Cervical Cancers and Pre-Cancers Diagnosed?

    Science.gov (United States)

    ... some find disturbing. Some places provide headphones with music to block this noise out. A mild sedative ... in Cervical Cancer Research? Other Resources and References Cancer Information Cancer Basics Cancer Prevention & Detection Signs & Symptoms ...

  2. Breast Cancer Detection

    Science.gov (United States)

    2000-01-01

    The BioScan System was developed by OmniCorder Technologies, Inc. at the Jet Propulsion Laboratory. The system is able to locate cancerous lesions by detecting the cancer's ability to recruit a new blood supply. A digital sensor detects infrared energy emitted from the body and identifies the minute differences accompanying the blood flow changes associated with cancerous cells. It also has potential use as a monitoring device during cancer treatment. This technology will reduce the time taken to detect cancerous cells and allow for earlier intervention, therefore increasing the overall survival rates of breast cancer patients.

  3. Cancer rehabilitation in Denmark

    DEFF Research Database (Denmark)

    Hansen, Helle Ploug; Tjørnhøj-Thomsen, Tine

    2008-01-01

    A fundamental assumption behind cancer rehabilitation in many Western societies is that cancer survivors can return to normal life by learning to deal with the consequences of their illness and their treatment. This assumption is supported by increasing political attention to cancer rehabilitation...... and a growth in residential cancer-rehabilitation initiatives in Denmark (Danish Cancer Society 1999; Government of Denmark 2003). On the basis of their ethnographic fieldwork in residential-cancer rehabilitation courses, the authors examine the new rehabilitation discourse. They argue that this discourse has...

  4. [Cancer and health economics].

    Science.gov (United States)

    Koinuma, N

    1996-01-01

    Health economics on cancer medicine is a supportive tool of cancer care and is becoming one of the essential weapons against cancer. Its principal roles are to enhance the quality and efficacy and to secure the finance necessary to the cancer care. The economic aspects of cancer medicine and the methods of economic evaluation are overviewed with emphasis on cost-benefit, cost-effectiveness and cost-utility analysis. The operational and interpretational checkpoints are introduced, and the problems and prospects of the practical use of the methods on clinical settings such as cancer chemotherapy are discussed. PMID:8546457

  5. Understanding your colon cancer risk

    Science.gov (United States)

    Colon cancer risk factors are things that increase the chance that you could get cancer. Some risk factors ... risk factors never get cancer. Other people get colon cancer but do not have any known risk factors. ...

  6. Get Tested for Colorectal Cancer

    Science.gov (United States)

    ... Colorectal Cancer Print This Topic En español Get Tested for Colorectal Cancer Browse Sections The Basics Overview ... cancer screening tests . Does it hurt to get tested? Some people find the tests for colorectal cancer ...

  7. Whipple Procedure for Pancreatic Cancer

    Medline Plus

    Full Text Available ... MD: In the list of cancers that cause death in this country, pancreas cancer is number four. ... it is the fourth leading cause of cancer death, principally because it is a very tough cancer ...

  8. Renal pelvis or ureter cancer

    Science.gov (United States)

    Transitional cell cancer of the renal pelvis or ureter; Kidney cancer - renal pelvis; Ureter cancer ... the urine collection system, but it is uncommon. Renal pelvis and ureter cancers affect men more often ...

  9. Breast Cancer Rates by State

    Science.gov (United States)

    ... Associated Lung Ovarian Prostate Skin Uterine Cancer Home Breast Cancer Rates by State Language: English Español (Spanish) Recommend ... from breast cancer each year. Rates of Getting Breast Cancer by State The number of people who get ...

  10. Pancreatic Cancer Stage 2A

    Science.gov (United States)

    ... 2A Description: Stage IIA pancreatic cancer; drawing shows cancer in the pancreas and duodenum. The bile duct and pancreatic duct are also shown. Stage IIA pancreatic cancer. Cancer has spread to nearby tissue and organs ...

  11. Pancreatic Cancer Stage 2B

    Science.gov (United States)

    ... 2B Description: Stage IIB pancreatic cancer; drawing shows cancer in the pancreas and in nearby lymph nodes. Also shown are the bile duct, pancreatic duct, and duodenum. Stage IIB pancreatic cancer. Cancer has spread to nearby lymph nodes and ...

  12. Lung cancer screening: radiological aspects

    NARCIS (Netherlands)

    de Hoop, B.J.

    2010-01-01

    Lung Cancer Screening: Radiological Aspects Multiple lung cancer screening studies are currently being conducted to study whether lung cancer screening with Computed Tomography (CT) can decrease lung cancer mortality. This thesis addresses radiological methods that can increase efficacy and efficien

  13. Cervical cancer - screening and prevention

    Science.gov (United States)

    Cancer cervix - screening; HPV - cervical cancer screening; Dysplasia - cervical cancer screening ... Almost all cervical cancers are caused by HPV (human papilloma virus). HPV is a common virus that spreads through sexual contact. Certain ...

  14. Treatment Option Overview (Bladder Cancer)

    Science.gov (United States)

    ... Cancer Treatment Bladder Cancer Screening Research Bladder Cancer Treatment (PDQ®)–Patient Version General Information About Bladder Cancer ... Certain factors affect prognosis (chance of recovery) and treatment options. The prognosis (chance of recovery ) depends on ...

  15. Treatment Option Overview (Colon Cancer)

    Science.gov (United States)

    ... Colorectal Cancer Colorectal Cancer Screening Research Colon Cancer Treatment (PDQ®)–Patient Version General Information About Colon Cancer ... Certain factors affect prognosis (chance of recovery) and treatment options. The prognosis (chance of recovery ) and treatment ...

  16. Treatment Option Overview (Cervical Cancer)

    Science.gov (United States)

    ... Cancer Prevention Cervical Cancer Screening Research Cervical Cancer Treatment (PDQ®)–Patient Version General Information About Cervical Cancer ... Certain factors affect prognosis (chance of recovery) and treatment options. The prognosis (chance of recovery) depends on ...

  17. Cancer risks in thyroid cancer patients.

    OpenAIRE

    Hall, P.; Holm, L E; Lundell, G.; Bjelkengren, G.; Larsson, L. G.; Lindberg, S.; Tennvall, J.; Wicklund, H.; Boice, J. D.

    1991-01-01

    Cancer risks were studied in 834 thyroid cancer patients given 131I (4,551 MBq, average) and in 1,121 patients treated by other means in Sweden between 1950 and 1975. Record-linkage with the Swedish Cancer Register identified 99 new cancers more than 2 years after 131I therapy [standardised incidence ratio (SIR) = 1.43; 95% confidence interval (CI) 1.17-1.75] vs 122 (SIR = 1.19; 95% CI 0.88-1.42) in patients not receiving 131I. In females treated with 131I overall SIR was 1.45 (95% CI 1.14-1....

  18. Treatment Option Overview (Pancreatic Cancer)

    Science.gov (United States)

    ... affect prognosis (chance of recovery) and treatment options. Pancreatic cancer is a disease in which malignant (cancer) cells form in the ... the cancer cells in the liver are actually pancreatic cancer cells. The disease is metastatic pancreatic cancer, not liver cancer. The ...

  19. General Information about Pancreatic Cancer

    Science.gov (United States)

    ... affect prognosis (chance of recovery) and treatment options. Pancreatic cancer is a disease in which malignant (cancer) cells form in the ... the cancer cells in the liver are actually pancreatic cancer cells. The disease is metastatic pancreatic cancer, not liver cancer. The ...

  20. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... to Cancer Self Image & Sexuality Day-to-Day Life Support for Caregivers Survivorship Questions to Ask About ... to Cancer Self Image & Sexuality Day to Day Life Survivorship Support for Caregivers Questions to Ask About ...

  1. Breast cancer (metastatic)

    OpenAIRE

    Stebbing, Justin; Slater, Sarah; Slevin, Maurice

    2007-01-01

    Median survival from metastatic breast cancer is 12 months without treatment, but young people can survive up to 20 years with the disease, whereas in other metastatic cancers this would be considered very unusual.

  2. Cancer Treatment Scams

    Science.gov (United States)

    ... Related Items Anatomy of a Cancer Treatment Scam Miracle Health Claims Discount Plan or Health Insurance? Cancer ... Talk to Your Doctor First. Tagged with: health , miracle claims , scam September 2008 You Might Also Like ...

  3. What Is Prostate Cancer?

    Medline Plus

    Full Text Available ... the more likely he is to develop the disease. Physician: Come on back, first room. Narrator: Most ... cancer. Prostate cancer is really a spectrum of diseases where on one end of the spectrum there ...

  4. Cancer and Thrombosis

    Institute of Scientific and Technical Information of China (English)

    刘敏涓

    2011-01-01

    @@ Relationship between cancer and thromboembolic disease, the research has been going on for more than a century.Armand trousseau in 1865 first reported the formation of venous thrombosis prone patients with gastric cancer.

  5. Cancer Pharmacoepidemiology and Pharmacogenomics

    Science.gov (United States)

    NCI has an increasing focus on pharmacoepidemiology related to pharmaceutical use and cancer risk, recurrence and survival, as well as pharmacoepidemiology related to treatment response and adverse outcomes from chemotherapeutic agents and other medications used to treat cancer.

  6. Tests for Liver Cancer

    Science.gov (United States)

    ... has come back after treatment Alpha-fetoprotein blood (AFP) test AFP is normally present at high levels in the ... liver disease, liver cancer, or other cancers. If AFP levels are very high in someone with a ...

  7. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... you have cancer, you and your loved ones face many unknowns. Understanding your cancer and knowing what ... make decisions. Some of the decisions you may face include: Which treatment is best for you If ...

  8. Liver (Hepatocellular) Cancer Screening

    Science.gov (United States)

    ... cancer is present in the body. Alpha-fetoprotein (AFP) is the most widely used tumor marker for ... and other types of cancer, may also increase AFP levels. Specific tumor markers that may lead to ...

  9. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Contacts Multicultural Media Outreach Program Events Scientific Meetings & Lectures Conferences Advisory Board Meetings Cancer Currents Blog Research ... Resources Media Contacts Multicultural Media Events Scientific Meetings & Lectures Conferences Advisory Board Meetings Cancer Currents Blog About ...

  10. Oral Cancer Exam

    Medline Plus

    Full Text Available ... Trials What Are Clinical Trials? About Clinical Trials Information for Clinical Researchers See All Browse Studies by ... been diagnosed with oral cancer, this brochure includes information on symptoms, diagnosis, and treatment of oral cancer, ...

  11. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... History Committees of Interest Legislative Resources Recent Public Laws Contact Overview History of NCI Contributing to Cancer ... History Committees of Interest Legislative Resources Recent Public Laws Careers Visitor Information Search Search Home About Cancer ...

  12. Cancer during Pregnancy

    Science.gov (United States)

    ... protection during x-rays. Computed tomography (CT or CAT) scans. CT scans are similar to x-rays ... a Baby After Cancer: Pregnancy Dating, Sex, and Reproduction Being a Young Adult with Cancer When the ...

  13. HPV and Cancer

    Science.gov (United States)

    ... Overview Cancer Prevention Overview–for health professionals Research HPV and Cancer On This Page What are human ... hpv/ E-mail: cdcinfo@cdc.gov Human Papillomavirus (HPV) | Did You Know? View this video on YouTube. ...

  14. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Contacts Other Funding Find NCI funding for small business innovation, technology transfer, and contracts Training Cancer Training ... Staging Prognosis Questions to Ask ... This statistic is another method used to estimate cancer-specific survival that does ...

  15. Head and Neck Cancer

    Science.gov (United States)

    ... cancerous or benign. A cancerous tumor is malignant, meaning it can grow and spread to other parts ... tumor’s size. Sometimes, a special dye called a contrast medium is given before the scan to provide ...

  16. Cancer immunotherapy in children

    Science.gov (United States)

    More often than not, cancer immunotherapies that work in adults are used in modified ways in children. Seldom are new therapies developed just for children, primarily because of the small number of pediatric patients relative to the adult cancer patient

  17. Oral Cancer Exam

    Medline Plus

    Full Text Available ... signs of oral cancer. For Patients and the Public Oral Cancer Pamphlet that describes the risk factors, ... not collect any actual information. External Web Site Policy This graphic notice ( ) means that you are leaving ...

  18. Cancer of the Testis

    Science.gov (United States)

    ... 1975-2013 Browse the Tables and Figures Access CSR Contents in PDF Generate Custom Reports About the ... Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2013/ , based on November 2015 SEER data ...

  19. Cancer of the Anus

    Science.gov (United States)

    ... 1975-2013 Browse the Tables and Figures Access CSR Contents in PDF Generate Custom Reports About the ... Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2013/ , based on November 2015 SEER data ...

  20. Cancer of the Larynx

    Science.gov (United States)

    ... 1975-2013 Browse the Tables and Figures Access CSR Contents in PDF Generate Custom Reports About the ... Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2013/ , based on November 2015 SEER data ...

  1. Cancer of the Thyroid

    Science.gov (United States)

    ... main types of thyroid cancer are papillary, follicular, medullary, and anaplastic thyroid cancer. The four types are ... on statistics from SEER and the Centers for Disease Control and Prevention's National Center for Health Statistics. ...

  2. Stages of Thyroid Cancer

    Science.gov (United States)

    ... enlarged thyroid). Having a family history of thyroid disease or thyroid cancer. Having certain genetic conditions such as familial medullary thyroid cancer (FMTC), multiple endocrine neoplasia type 2A ...

  3. Types of Breast Cancers

    Science.gov (United States)

    ... about this condition, see Inflammatory Breast Cancer . Paget disease of the nipple This type of breast cancer ... carcinoma (this is a type of metaplastic carcinoma) Medullary carcinoma Mucinous (or colloid) carcinoma Papillary carcinoma Tubular ...

  4. Oral Cancer Exam

    Medline Plus

    Full Text Available ... Dental Research See All Continuing Education Practical Oral Care for People With Developmental Disabilities – This booklet presents ... developmental disabilities and offers strategies for providing oral care. NIDCR > OralHealth > Topics > Oral Cancer > Oral Cancer Exam ...

  5. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... to Cancer Self Image & Sexuality Day-to-Day Life For Family & Friends Survivorship Questions to Ask About ... to Cancer Self Image & Sexuality Day to Day Life Survivorship For Family & Friends Questions to Ask About ...

  6. CDC WONDER: Cancer Statistics

    Data.gov (United States)

    U.S. Department of Health & Human Services — The United States Cancer Statistics (USCS) online databases in WONDER provide cancer incidence and mortality data for the United States for the years since 1999, by...

  7. Learning about Skin Cancer

    Science.gov (United States)

    ... Why Deadly Skin Cancers Spread 2000 News Release Learning About Skin Cancer What are the most common ... skin surface. When a melanoma becomes thick and deep, the disease often spreads to other parts of ...

  8. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Research Cancer Treatment Types of Treatment Side Effects Clinical Trials Information for Patients and Caregivers A to ... Staging Prognosis Treatment Types of Treatment Side Effects Clinical Trials Cancer Drugs Complementary & Alternative Medicine Coping Feelings & ...

  9. Stages of Skin Cancer

    Science.gov (United States)

    ... cells than in normal cells. For skin cancer, laser light is shined onto the skin and the drug becomes active and kills the cancer cells. Photodynamic therapy causes little damage to healthy tissue. Biologic therapy ...

  10. Skin Cancer Treatment

    Science.gov (United States)

    ... cells than in normal cells. For skin cancer, laser light is shined onto the skin and the drug becomes active and kills the cancer cells. Photodynamic therapy causes little damage to healthy tissue. Biologic therapy ...

  11. Tobacco and cancer (image)

    Science.gov (United States)

    Tobacco and its various components increase the risk of several types of cancer especially cancer of the lung, mouth, larynx, esophagus, bladder, kidney, pancreas, and cervix. Smoking also increases ...

  12. Lung and Bronchus Cancer

    Science.gov (United States)

    ... copy to myself The information used on this page will not be used to send unsolicited emails or shared with a third party. HPF: Did You Know? Video Series Lung Cancer - Did you know that lung cancer is the ...

  13. Oral Cancer Exam

    Medline Plus

    Full Text Available ... Text size: Website Contents NIDCR Home Oral Health Diseases and Conditions Gum Disease TMJ Disorders Oral Cancer ... Tooth Decay See All Oral Complications of Systemic Diseases Cancer Treatment Developmental Disabilities Diabetes Heart Disease HIV/ ...

  14. Stomach Cancer Risk Questionnaire

    Science.gov (United States)

    ... Jewish Hospital and Washington University School of Medicine Stomach cancer is fairly rare in the US, but ... the early stages. To estimate your risk of stomach cancer and learn about ways to lower that ...

  15. Breast Cancer Disparities

    Science.gov (United States)

    ... 2.65 MB] Read the MMWR Science Clips Breast Cancer Black Women Have Higher Death Rates from Breast ... of Page U.S. State Info Number of Additional Breast Cancer Deaths Among Black Women, By State SOURCE: National ...

  16. Breast cancer staging

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000911.htm Breast cancer staging To use the sharing features on this ... Once your health care team knows you have breast cancer , they will do more tests to stage it. ...

  17. Prostate cancer staging

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000397.htm Prostate cancer staging To use the sharing features on this ... trials you may be able to join How Prostate Cancer Staging is Done Initial staging is based on ...

  18. Localized Prostate Cancer

    Science.gov (United States)

    ... a decision aid for men with clinically localized prostate cancer (available at http://effectivehealthcare.ahrq.gov/prostate_da) ... A Decision Aid for Men With Clinically Localized Prostate Cancer Page 1 of 24 Introduction Men with clinically ...

  19. Cancer Prevention Overview (PDQ)

    Science.gov (United States)

    ... lung cancer and secondhand tobacco smoke , outdoor air pollution, and asbestos . Drinking water that contains a large amount of arsenic has been linked to skin , bladder, and lung cancers. Studies have been done ...

  20. Detecting Prostate Cancer

    Medline Plus

    Full Text Available ... abnormal and raises the index of suspicion that cancer may be present. Narrator: While the use of ... examination does not mean that they have prostate cancer. It means that we're concerned about it ...

  1. Oral Cancer Exam

    Medline Plus

    Full Text Available ... video shows what happens during an oral cancer examination. Quick and painless, the exam can detect oral ... Step-by-step description of the oral cancer examination so patients know what to expect. What You ...

  2. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Outreach Program Events Scientific Meetings & Lectures Conferences Advisory Board Meetings Cancer Currents Blog Research Findings Drug Approvals ... Multicultural Media Events Scientific Meetings & Lectures Conferences Advisory Board Meetings Cancer Currents Blog About NCI NCI Overview ...

  3. Surgery for pancreatic cancer

    Science.gov (United States)

    ... medlineplus.gov/ency/article/007649.htm Surgery for pancreatic cancer To use the sharing features on this page, ... surgery are used in the surgical treatment of pancreatic cancer. Whipple procedure: This is the most common surgery ...

  4. Prostate cancer in Denmark

    DEFF Research Database (Denmark)

    Brasso, K; Friis, S; Kjaer, S K;

    1998-01-01

    To review the trends in prostate cancer (PC) incidence and mortality rates in Denmark during a 50-year period.......To review the trends in prostate cancer (PC) incidence and mortality rates in Denmark during a 50-year period....

  5. Cancer in Children

    Science.gov (United States)

    Cancer begins in the cells, which are the building blocks of your body. Normally, new cells form ... can form a tumor. Benign tumors aren't cancer while malignant ones are. Malignant tumor cells can ...

  6. Cancer Alternative Therapies

    Science.gov (United States)

    You have many choices to make about your cancer treatment. One choice you might be thinking about ... are acupuncture, chiropractic, and herbal medicines. People with cancer may use CAM to Help cope with the ...

  7. Adrenal Gland Cancer

    Science.gov (United States)

    ... either benign or malignant. Benign tumors aren't cancer. Malignant ones are. Most adrenal gland tumors are ... and may not require treatment. Malignant adrenal gland cancers are uncommon. Types of tumors include Adrenocortical carcinoma - ...

  8. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Meetings Cancer Currents Blog About NCI NCI Overview History Contributing to Cancer Research Leadership Director's Page Previous ... Information Legislative Activities Hearings & Testimonies Current Congress Legislative History Committees of Interest Legislative Resources Recent Public Laws ...

  9. Oral Cancer Exam

    Medline Plus

    Full Text Available ... Professionals A step-by-step, illustrated guide for health professionals that provides instruction on examining the mouth for signs of oral cancer. For Patients and the Public Oral Cancer Pamphlet that describes the risk factors, ...

  10. Oral Cancer Exam

    Medline Plus

    Full Text Available ... See All Oral Complications of Systemic Diseases Cancer Treatment Developmental Disabilities Diabetes Heart Disease HIV/AIDS See ... this brochure includes information on symptoms, diagnosis, and treatment of oral cancer, along with definitions of selected ...

  11. Prostate Cancer Prevention

    Science.gov (United States)

    ... prostate cancer increases as men get older. Family history of prostate cancer A man whose father, brother, ... some foods, such as green vegetables, beans and orange juice. Folic acid is a man-made form ...

  12. Immortality of cancers

    OpenAIRE

    Duesberg, Peter; McCormack, Amanda

    2013-01-01

    Immortality is a common characteristic of cancers, but its origin and purpose are still unclear. Here we advance a karyotypic theory of immortality based on the theory that carcinogenesis is a form of speciation. Accordingly, cancers are generated from normal cells by random karyotypic rearrangements and selection for cancer-specific reproductive autonomy. Since such rearrangements unbalance long-established mitosis genes, cancer karyotypes vary spontaneously but are stabilized perpetually by...

  13. Obesity and Cancer

    OpenAIRE

    WOLIN, KATHLEEN Y.; Carson, Kenneth; Colditz, Graham A.

    2010-01-01

    Weight, weight gain, and obesity account for approximately 20% of all cancer cases. Evidence on the relation of each to cancer is summarized, including esophageal, thyroid, colon, renal, liver, melanoma, multiple myeloma, rectum, gallbladder, leukemia, lymphoma, and prostate in men; and postmenopausal breast and endometrium in women. Different mechanisms drive etiologic pathways for these cancers. Weight loss, particularly among postmenopausal women, reduces risk for breast cancer. Among canc...

  14. Urologic cancer in China.

    Science.gov (United States)

    Pang, Cheng; Guan, Youyan; Li, Hongbo; Chen, Wanqing; Zhu, Gang

    2016-06-01

    Cancer remains to be the second most common cause of death, and its incidence and mortality rates are increasing in China. According to the 2015 National Central Cancer Registry (NCCR) of China, the incidence of bladder cancer and prostate cancer ranked sixth and seventh, respectively, in male cancers. The majority of prostate cancer patients were diagnosed at an advanced stage. Early diagnosis of prostate cancer is the key to improve prostate cancer survival in China. Radical prostatectomy or radical radiotherapy is the main treatment for localized prostate cancer, and a comprehensive therapy based on androgen deprivation therapy is the treatment for advanced disease. The most common histologic types of bladder cancer in China were urothelial carcinoma, followed by adenocarcinoma and squamous carcinoma. The majority of patients were diagnosed using white-light cystoscopy with biopsy. Fluorescence and narrow-band imaging cystoscopy had additional detection rates and are becoming more popular. Following Chinese guidelines, most non-muscle invasive bladder cancer patients were treated with diagnostic transurethral resection and more than half of the muscle invasive bladder cancer patients were treated with radical cystectomy. Due to the increased detection rate of kidney tumors by ultrasound in physical examination, the number of incidentally diagnosed renal cell carcinoma has increased. Localized kidney cancers are more and more often treated by nephron-sparing surgery. Radical nephrectomy is still the main treatment option for patients with locally advanced renal cell carcinoma. Both laparoscopic and robotic-assisted laparoscopic surgeries have been used in big medical centers. Both testicular cancer and penile cancer have lower incidence levels than that in Europe. As we have an enormous population base, the absolute patient number is big. The diagnosis and treatment follows the Chinese guidelines. In China, both medical professionals and public should concern

  15. Diabetes and pancreatic cancer

    OpenAIRE

    MUNIRAJ, T.; Chari, S.T.

    2012-01-01

    The relationship between diabetes and pancreatic cancer is complex. Diabetes or impaired glucose tolerance is present in more than 2/3rd of pancreatic cancer patients. Epidemiological studies have consistently shown a modest increase in the risk of pancreatic cancer in type 2 diabetes, with an inverse relationship to duration of disease. Additionally, recent studies suggest that anti-diabetic medications may modulate the risk of pancreatic cancer in type 2 diabetes. Subjects >50 years of age ...

  16. Nanomedicine and cancer therapies

    CERN Document Server

    Sebastian, Mathew; Elias, Eldho

    2012-01-01

    Introduction Nanotechnological-Based Systems for CancerIn vivo Spectroscopy for Detection and Treatment of GBM with NPt® ImplantationNanobiotechnology for Antibacterial Therapy and DiagnosisChitosan NanoparticlesSynthesis and Biomedical Application of Silver NanoparticlesRecent Advances in Cancer Therapy Using PhytochemicalsMitochondrial Dysfunction and Cancer: Modulation by Palladium-Lipoic Acid ComplexUnity of Mind and Body: The Concept of Life Purpose DominantThuja Occidentalis and Breast Cancer ChemopreventionAntioxidants and Com

  17. Breast Cancer Immunotherapy

    Institute of Scientific and Technical Information of China (English)

    Juhua Zhou; Yin Zhong

    2004-01-01

    Breast cancer is a leading cause of cancer-related deaths in women worldwide. Although tumorectomy,radiotherapy, chemotherapy and hormone replacement therapy have been used for the treatment of breast cancer, there is no effective therapy for patients with invasive and metastatic breast cancer. Immunotherapy may be proved effective in treating patients with advanced breast cancer. Breast cancer immunotherapy includes antibody based immunotherapy, cancer vaccine immunotherapy, adoptive T cell transfer immunotherapy and T cell receptor gene transfer immunotherapy. Antibody based immunotherapy such as the monoclonal antibody against HER-2/neu (trastuzumab) is successfully used in the treatment of breast cancer patients with over-expressed HER-2/neu, however, HER-2/neu is over-expressed only in 25-30% of breast cancer patients. Cancer vaccine immunotherapy is a promising method to treat cancer patients. Cancer vaccines can be used to induce specific anti-tumor immunity in breast cancer patients, but cannot induce objective tumor regression. Adoptive T cell transfer immunotherapy is an effective method in the treatment of melanoma patients. Recent advances in anti-tumor T cell generation ex vivo and limited clinical trial data have made the feasibility of adoptive T cell transfer immunotherapy in the treatment of breast cancer patients. T cell receptor gene transfer can redirect the specificity of T cells. Chimeric receptor, scFv(anti-HER-2/neu)/zeta receptor, was successfully used to redirect cytotoxic T lymphocyte hybridoma cells to obtain anti-HER-2/neu positive tumor cells, suggesting the feasibility of treatment of breast cancer patients with T cell receptor gene transfer immunotherapy. Clinical trials will approve that immunotherapy is an effective method to cure breast cancer disease in the near future.

  18. Breast Cancer Immunotherapy

    Institute of Scientific and Technical Information of China (English)

    JuhuaZhou; YinZhong

    2004-01-01

    Breast cancer is a leading cause of cancer-related deaths in women worldwide. Although tumorectomy, radiotherapy, chemotherapy and hormone replacement therapy have been used for the treatment of breast cancer, there is no effective therapy for patients with invasive and metastatic breast cancer. Immunotherapy may be proved effective in treating patients with advanced breast cancer. Breast cancer immunotherapy includes antibody based immunotherapy, cancer vaccine immunotherapy, adoptive T cell transfer immunotherapy and T cell receptor gene transfer immunotherapy. Antibody based immunotherapy such as the monoclonal antibody against HER-2/neu (trastuzumab) is successfully used in the treatment of breast cancer patients with over-expressed HER-2/neu, however, HER-2/neu is over-expressed only in 25-30% of breast cancer patients. Cancer vaccine immunotherapy is a promising method to treat cancer patients. Cancer vaccines can be used to induce specific anti-tumor immunity in breast cancer patients, but cannot induce objective tumor regression. Adoptive T cell transfer immunotherapy is an effective method in the treatment of melanoma patients. Recent advances in anti-tumor T cell generation ex vivo and limited clinical trial data have made the feasibility of adoptive T cell transfer immunotherapy in the treatment of breast cancer patients. T cell receptor gene transfer can redirect the specificity of T cells. Chimeric receptor, scFv(anti-HER-2/neu)/zeta receptor, was successfully used to redirect cytotoxic T lymphocyte hybridoma cells to obtain anti-HER-2/neu positive tumor cells, suggesting the feasibility of treatment of breast cancer patients with T cell receptor gene transfer immunotherapy. Clinical trials will approve that immunotherapy is an effective method to cure breast cancer disease in the near future. Cellular & Molecular Immunology.

  19. Evolutionary theory of cancer.

    Science.gov (United States)

    Attolini, Camille Stephan-Otto; Michor, Franziska

    2009-06-01

    As Theodosius Dobzhansky famously noted in 1973, "Nothing in biology makes sense except in the light of evolution," and cancer is no exception to this rule. Our understanding of cancer initiation, progression, treatment, and resistance has advanced considerably by regarding cancer as the product of evolutionary processes. Here we review the literature of mathematical models of cancer evolution and provide a synthesis and discussion of the field.

  20. AUTOPHAGY IN LUNG CANCER

    OpenAIRE

    Jaboin, Jerry J.; Hwang, Misun; Lu, Bo

    2009-01-01

    Lung cancer is the leading cause of cancer-related deaths worldwide. The relatively poor cure rate in lung cancer patients has been associated with a resistance to chemotherapy and radiation that is at least in part related to defects in cellular apoptotic machinery. Exploitation of another form of cell death, autophagy, has the capacity to improve the therapeutic gain of current therapies. In an effort to develop novel treatment strategies to enhance the therapeutic ratio for lung cancer, we...

  1. Understanding Cancer Prognosis

    Science.gov (United States)

    Español 1-800-4-CANCER Live Chat Publications Dictionary Menu Contact Dictionary Search About Cancer Causes and Prevention Risk Factors ... Contacts Other Funding Find NCI funding for small business innovation, technology transfer, and contracts Training Cancer Training ...

  2. National Cancer Institute

    Science.gov (United States)

    ... Español 1-800-4-CANCER Live Chat Publications Dictionary Menu Contact Dictionary Search About Cancer Causes and Prevention Risk Factors ... Contacts Other Funding Find NCI funding for small business innovation, technology transfer, and contracts Training Cancer Training ...

  3. Anal Cancer Treatment

    Science.gov (United States)

    ... Español 1-800-4-CANCER Live Chat Publications Dictionary Menu Contact Dictionary Search About Cancer Causes and Prevention Risk Factors ... Contacts Other Funding Find NCI funding for small business innovation, technology transfer, and contracts Training Cancer Training ...

  4. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available Español 1-800-4-CANCER Live Chat Publications Dictionary Menu Contact Dictionary Search About Cancer Causes and Prevention Risk Factors ... Contacts Other Funding Find NCI funding for small business innovation, technology transfer, and contracts Training Cancer Training ...

  5. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available Español 1-800-4-CANCER Live Chat Publications Dictionary Menu Contact Dictionary Search About Cancer Causes and ... MORE INFORMATION About This Website Cancer.gov en español Multimedia Publications Site Map Digital Standards for NCI ...

  6. Cell phones and cancer

    Science.gov (United States)

    Cancer and cell phones; Do cell phones cause cancer? ... Several major studies show no link between cell phones and cancer at this time. However, since the information available is based on short-term studies, the impact of many years of ...

  7. Breast Cancer (For Kids)

    Science.gov (United States)

    ... With Breast Cancer Breast Cancer Prevention en español Cáncer de mama You may have heard about special events, like walks or races, to raise money for breast cancer research. Or maybe you've seen people wear ...

  8. Cancer Care and Control

    OpenAIRE

    Schneidman, Miriam; Jeffers, Joanne; Duncan, Kalina

    2015-01-01

    Worldwide, deaths from cancer exceed those caused by human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS), tuberculosis, and malaria combined. Seventy percent of deaths due to cancer occur in low-and middle-income countries, which are often poorly prepared to deal with the growing burden of chronic disease. Over a period of 18 months, the cancer care and control...

  9. Lung Cancer Indicators Recurrence

    Science.gov (United States)

    This study describes prognostic factors for lung cancer spread and recurrence, as well as subsequent risk of death from the disease. The investigators observed that regardless of cancer stage, grade, or type of lung cancer, patients in the study were more

  10. Cancer Epidemiology Matters Blog

    Science.gov (United States)

    The Cancer Epidemiology Matters blog helps foster a dialogue between the National Cancer Institute's (NCI) Epidemiology and Genomics Research Program (EGRP), extramural researchers, and other individuals, such as clinicians, community partners, and advocates, who are interested in cancer epidemiology and genomics.

  11. Multiple Primary Cancer Monograph

    Science.gov (United States)

    To identify groups of cancer survivors that are at increased risk for multiple primary cancers, investigators led an effort to provide the first comprehensive population-based analysis of the risk of subsequent cancer in the U.S., resulting in a monograph.

  12. CDC's Cervical Cancer Study

    Science.gov (United States)

    ... in Cancer Moonshot Stay Informed CDC’s Cervical Cancer Study Language: English Español (Spanish) Recommend on Facebook Tweet ... year. As part of CDC’s Cervical Cancer (Cx3) Study, we surveyed a sample of both health care ...

  13. Ovarian cancer and smoking

    DEFF Research Database (Denmark)

    Beral, V; Gaitskell, K; Hermon, C;

    2012-01-01

    Smoking has been linked to mucinous ovarian cancer, but its effects on other ovarian cancer subtypes and on overall ovarian cancer risk are unclear, and the findings from most studies with relevant data are unpublished. To assess these associations, we review the published and unpublished evidence....

  14. Salivary Gland Cancer

    Science.gov (United States)

    ... contains antibodies that can kill germs. Salivary gland cancer is a type of head and neck cancer. It is rare. It may not cause any ... pain in your face Doctors diagnose salivary gland cancer using a physical exam, imaging tests, and a ...

  15. Pancreatic Cancer Stage 4

    Science.gov (United States)

    ... lung, liver, and peritoneal cavity. An inset shows cancer cells spreading from the pancreas, through the blood and lymph system, to another ... abdomen that contains the intestines, stomach, and liver). Cancer may also have spread to ... pancreas or to lymph nodes. Stage IV pancreatic cancer. ...

  16. Antioxidants and Cancer Prevention

    Science.gov (United States)

    ... or other cancers, including lymphoma, leukemia, melanoma, and cancers of the lung, bladder, pancreas, and colon and rectum ( 26 ). Overall, these nine ... the incidence and mortality of carcinoma of the pancreas in a randomized, controlled trial. Cancer 1999; 86(1):37-42. [PubMed Abstract] Virtamo ...

  17. Cancer and Women

    Science.gov (United States)

    ... Framework in a Mammography Promotion Campaign African American Women and Mass Media Campaign Evaluation Cancer Survival: The Start of Global ... Reducing Indoor Tanning Cervical Cancer Rates Among Young Women in the ... Use Social Media Skin Cancer Risk Behaviors Among U.S. Adults Annual ...

  18. Cancer and Men

    Science.gov (United States)

    ... Framework in a Mammography Promotion Campaign African American Women and Mass Media Campaign Evaluation Cancer Survival: The Start of Global ... Reducing Indoor Tanning Cervical Cancer Rates Among Young Women in the ... Use Social Media Skin Cancer Risk Behaviors Among U.S. Adults Annual ...

  19. Cervical Cancer Stage IA

    Science.gov (United States)

    ... historical Searches are case-insensitive Cervical Cancer Stage IA Add to My Pictures View /Download : Small: 720x576 ... Large: 3000x2400 View Download Title: Cervical Cancer Stage IA Description: Stage IA1 and IA2 cervical cancer; drawing ...

  20. Cancer control in Bangladesh.

    Science.gov (United States)

    Hussain, Syed Akram; Sullivan, Richard

    2013-12-01

    Cancer is predicted to be an increasingly important cause of morbidity and mortality in Bangladesh in the next few decades. The estimated incidence of 12.7 million new cancer cases will rise to 21.4 million by 2030. More than two-thirds of the total expenditure on health is through out-of-pocket payments. According to the Bangladesh Bureau of Statistics, cancer is the sixth leading cause of death. International Agency for Research on Cancer has estimated cancer-related death rates in Bangladesh to be 7.5% in 2005 and 13% in 2030. The two leading causes are in males are lung and oral cancer and in females are breast cancer and cervical cancer. Bangladesh is now in severe shortage of radiation therapy machines, hospital bed, trained oncologists, medical radiation physicists and technologists. Bangladesh having different cancers associated with smoking and smokeless tobacco use, Human papilloma virus infection, Hepatitis B and C infection, Helicobacter Pylori infection, arsenic contaminated groundwater, availability of chemical carcinogens mainly formalin treated fruits, fish and vegetables at open market, tannery waste contaminated with chromium (which is used for poultry feed and fish feed preparation). A World Health Organization study revealed the annual cost of illnesses in Bangladesh attributable to tobacco usage is US$ 500 million and the total annual benefit from the tobacco sector is US$ 305 million as tax revenue. Bangladesh has developed a National Cancer Control Strategy and Action Plan with the aim of delivering a universal, quality-based and timely service. Cancer prevention through tobacco control, health promotion and vaccination program, cancer early detection program for oral cavity, breast and cervix has initiated. Cancer detection and diagnostic facilities will be made available at medical colleges and district- hospitals and establish a referral chain. National capacity development, more cancer research will allow Bangladesh to deal effectively

  1. Cancer control in Bangladesh.

    Science.gov (United States)

    Hussain, Syed Akram; Sullivan, Richard

    2013-12-01

    Cancer is predicted to be an increasingly important cause of morbidity and mortality in Bangladesh in the next few decades. The estimated incidence of 12.7 million new cancer cases will rise to 21.4 million by 2030. More than two-thirds of the total expenditure on health is through out-of-pocket payments. According to the Bangladesh Bureau of Statistics, cancer is the sixth leading cause of death. International Agency for Research on Cancer has estimated cancer-related death rates in Bangladesh to be 7.5% in 2005 and 13% in 2030. The two leading causes are in males are lung and oral cancer and in females are breast cancer and cervical cancer. Bangladesh is now in severe shortage of radiation therapy machines, hospital bed, trained oncologists, medical radiation physicists and technologists. Bangladesh having different cancers associated with smoking and smokeless tobacco use, Human papilloma virus infection, Hepatitis B and C infection, Helicobacter Pylori infection, arsenic contaminated groundwater, availability of chemical carcinogens mainly formalin treated fruits, fish and vegetables at open market, tannery waste contaminated with chromium (which is used for poultry feed and fish feed preparation). A World Health Organization study revealed the annual cost of illnesses in Bangladesh attributable to tobacco usage is US$ 500 million and the total annual benefit from the tobacco sector is US$ 305 million as tax revenue. Bangladesh has developed a National Cancer Control Strategy and Action Plan with the aim of delivering a universal, quality-based and timely service. Cancer prevention through tobacco control, health promotion and vaccination program, cancer early detection program for oral cavity, breast and cervix has initiated. Cancer detection and diagnostic facilities will be made available at medical colleges and district- hospitals and establish a referral chain. National capacity development, more cancer research will allow Bangladesh to deal effectively

  2. 78 FR 11895 - Prospective Grant of Exclusive License: Development of MUC-1 Tumor Associated Antigens as Cancer...

    Science.gov (United States)

    2013-02-20

    ...-1 Tumor Associated Antigens as Cancer Vaccines for Bladder Cancer, Breast Cancer, Colorectal Cancer, Gastric Cancer, Kidney Cancer, Liver Cancer, Lung Cancer, Ovarian Cancer, Prostate Cancer and Pancreatic..., gastric cancer, kidney cancer, liver cancer, lung cancer, ovarian......

  3. Improving Goals of Care Discussion in Advanced Cancer Patients

    Science.gov (United States)

    2016-06-30

    Primary Stage IV Hepatobiliary; Esophageal; Colorectal Cancer; Glioblastoma; Cancer of Stomach; Cancer of Pancreas; Melanoma; Head or Neck Cancer; Stage III; Stage IV; Lung Cancers; Pancreatic Cancers

  4. Mevalonate metabolism in cancer.

    Science.gov (United States)

    Gruenbacher, Georg; Thurnher, Martin

    2015-01-28

    Cancer cells are characterized by sustained proliferative signaling, insensitivity to growth suppressors and resistance to apoptosis as well as by replicative immortality, the capacity to induce angiogenesis and to perform invasive growth. Additional hallmarks of cancer cells include the reprogramming of energy metabolism as well as the ability to evade immune surveillance. The current review focuses on the metabolic reprogramming of cancer cells and on the immune system's capacity to detect such changes in cancer cell metabolism. Specifically, we focus on mevalonate metabolism, which is a target for drug and immune based cancer treatment. PMID:24467965

  5. Cancer Control in Bangladesh

    OpenAIRE

    Hussain, Syed Akram; Sullivan, Richard

    2013-01-01

    Cancer is predicted to be an increasingly important cause of morbidity and mortality in Bangladesh in the next few decades. The estimated incidence of 12.7 million new cancer cases will rise to 21.4 million by 2030. More than two-thirds of the total expenditure on health is through out-of-pocket payments. According to the Bangladesh Bureau of Statistics, cancer is the sixth leading cause of death. International Agency for Research on Cancer has estimated cancer-related death rates in Banglade...

  6. Preventing cervical cancer globally.

    Science.gov (United States)

    Schmeler, Kathleen M

    2012-11-01

    Cervical cancer is one of the leading causes of cancer and cancer-related deaths among women worldwide. More than 85% of cases and deaths occur in the developing world where the availability of effective screening is limited. In this issue of the journal, Pierce and colleagues (beginning on page 1273) describe a novel technique using a high-resolution microendoscope (HRME) to diagnose cervical dysplasia. This perspective reviews the limitations of existing cervical cancer screening methods currently in use in low-resource settings and the potential for HRME imaging to contribute to cervical cancer prevention in the developing world.

  7. Women and lung cancer.

    OpenAIRE

    Itri, L

    1987-01-01

    Lung cancer has now surpassed breast cancer as the leading cause of cancer deaths in American women. In 1986, 49,000 women were diagnosed as having lung cancer; only 16 percent of them will survive 5 years or more. Cigarette smoking is unquestionably the leading contributing factor. Large numbers of women took up cigarette smoking during and after World War II. The grim aftermath has taken 20 years to surface--between 1950 and 1985, lung cancer deaths in women increased 500 percent. Even wors...

  8. Heritable Gastrointestinal Cancer Syndromes.

    Science.gov (United States)

    Stoffel, Elena M

    2016-09-01

    Although almost all gastrointestinal cancers develop from sporadic genomic events, approximately 5% arise from germline mutations in genes associated with cancer predisposition. The number of these genes continues to increase. Tumor phenotypes and family history provide the framework for identifying at-risk individuals. The diagnosis of a hereditary cancer syndrome has implications for management of patients and their families. Systematic approaches that integrate family history and molecular characterization of tumors and polyps facilitate identification of individuals with this genetic predisposition. This article summarizes diagnosis and management of hereditary cancer syndromes associated with gastrointestinal cancers. PMID:27546846

  9. CANCER CAN BE PREVENTED

    Directory of Open Access Journals (Sweden)

    Akula Annapurna

    2013-09-01

    Full Text Available Life style factors are contributing significantly in cancer prevention. With the intake of proper and balanced diet ,cancer prevention is possible. Many foods are associated either with incidence or prevention of cancer. Plant based foods like fresh fruits, vegetables and whole grains rich in fiber, b-carotene, vitamins and antioxidants can prevent cancer. Fiber rich foods increase bowel movement, decreasing the absorption of cholesterol. Pumpkin, carrots contain b-carotenes. Leafy vegetables, broccoli, cabbage, cauliflower, peas and beans are rich in fiber and stimulate cancer preventing enzyme induction. Vitamin C rich citrus fruits can stimulate immune system. Garlic and onions can stimulate enzymes that can suppress tumor growth. Turmeric used in cooking can prevent colorectal cancer. Topical application of turmeric can prevent breast cancer in women. On the other hand, certain foods can cause cancer. Refined foods, high fat foods, deep fried foods, processed foods and low fiber foods increase cancer risk. Red meat, processed meat and barbeques contain a carcinogen called acrylamide. Foods prepared with hydrogenated fats contain transfats which increase risk for breast, ovarian, cervical and lung cancer. Consumption of alcohol increasing the risk for cancers of digestive system. LET US EAT RIGHT FOODS AND AVOID WRONG FOODS.

  10. Viruses and Breast Cancer

    Directory of Open Access Journals (Sweden)

    James S. Lawson

    2010-04-01

    Full Text Available Viruses are the accepted cause of many important cancers including cancers of the cervix and anogenital area, the liver, some lymphomas, head and neck cancers and indirectly human immunodeficiency virus associated cancers. For over 50 years, there have been serious attempts to identify viruses which may have a role in breast cancer. Despite these efforts, the establishment of conclusive evidence for such a role has been elusive. However, the development of extremely sophisticated new experimental techniques has allowed the recent development of evidence that human papilloma virus, Epstein-Barr virus, mouse mammary tumor virus and bovine leukemia virus may each have a role in the causation of human breast cancers. This is potentially good news as effective vaccines are already available to prevent infections from carcinogenic strains of human papilloma virus, which causes cancer of the uterine cervix.

  11. Diet and lung cancer

    DEFF Research Database (Denmark)

    Fabricius, P; Lange, Peter

    2003-01-01

    Lung cancer is the leading cause of cancer-related deaths worldwide. While cigarette smoking is of key importance, factors such as diet also play a role in the development of lung cancer. MedLine and Embase were searched with diet and lung cancer as the key words. Recently published reviews...... and large well designed original articles were preferred to form the basis for the present article. A diet rich in fruit and vegetables reduces the incidence of lung cancer by approximately 25%. The reduction is of the same magnitude in current smokers, ex-smokers and never smokers. Supplementation...... with vitamins A, C and E and beta-carotene offers no protection against the development of lung cancer. On the contrary, beta-carotene supplementation has, in two major randomised intervention trials, resulted in an increased mortality. Smoking remains the leading cause of lung cancer. The adverse effects...

  12. Diet and lung cancer

    DEFF Research Database (Denmark)

    Fabricius, P; Lange, Peter

    2003-01-01

    and large well designed original articles were preferred to form the basis for the present article. A diet rich in fruit and vegetables reduces the incidence of lung cancer by approximately 25%. The reduction is of the same magnitude in current smokers, ex-smokers and never smokers. Supplementation......Lung cancer is the leading cause of cancer-related deaths worldwide. While cigarette smoking is of key importance, factors such as diet also play a role in the development of lung cancer. MedLine and Embase were searched with diet and lung cancer as the key words. Recently published reviews...... with vitamins A, C and E and beta-carotene offers no protection against the development of lung cancer. On the contrary, beta-carotene supplementation has, in two major randomised intervention trials, resulted in an increased mortality. Smoking remains the leading cause of lung cancer. The adverse effects...

  13. Viruses and Breast Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Lawson, James S., E-mail: james.lawson@unsw.edu.au; Heng, Benjamin [School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney (Australia)

    2010-04-30

    Viruses are the accepted cause of many important cancers including cancers of the cervix and anogenital area, the liver, some lymphomas, head and neck cancers and indirectly human immunodeficiency virus associated cancers. For over 50 years, there have been serious attempts to identify viruses which may have a role in breast cancer. Despite these efforts, the establishment of conclusive evidence for such a role has been elusive. However, the development of extremely sophisticated new experimental techniques has allowed the recent development of evidence that human papilloma virus, Epstein-Barr virus, mouse mammary tumor virus and bovine leukemia virus may each have a role in the causation of human breast cancers. This is potentially good news as effective vaccines are already available to prevent infections from carcinogenic strains of human papilloma virus, which causes cancer of the uterine cervix.

  14. Viruses and Breast Cancer

    International Nuclear Information System (INIS)

    Viruses are the accepted cause of many important cancers including cancers of the cervix and anogenital area, the liver, some lymphomas, head and neck cancers and indirectly human immunodeficiency virus associated cancers. For over 50 years, there have been serious attempts to identify viruses which may have a role in breast cancer. Despite these efforts, the establishment of conclusive evidence for such a role has been elusive. However, the development of extremely sophisticated new experimental techniques has allowed the recent development of evidence that human papilloma virus, Epstein-Barr virus, mouse mammary tumor virus and bovine leukemia virus may each have a role in the causation of human breast cancers. This is potentially good news as effective vaccines are already available to prevent infections from carcinogenic strains of human papilloma virus, which causes cancer of the uterine cervix

  15. Pain in cancer survivors.

    Science.gov (United States)

    Brown, Matthew Rd; Ramirez, Juan D; Farquhar-Smith, Paul

    2014-11-01

    Cancer and its treatment exert a heavy psychological and physical toll. Of the myriad symptoms which result, pain is common, encountered in between 30% and 60% of cancer survivors. Pain in cancer survivors is a major and growing problem, impeding the recovery and rehabilitation of patients who have beaten cancer and negatively impacting on cancer patients' quality of life, work prospects and mental health. Persistent pain in cancer survivors remains challenging to treat successfully. Pain can arise both due to the underlying disease and the various treatments the patient has been subjected to. Chemotherapy causes painful chemotherapy-induced peripheral neuropathy (CIPN), radiotherapy can produce late effect radiation toxicity and surgery may lead to the development of persistent post-surgical pain syndromes. This review explores a selection of the common causes of persistent pain in cancer survivors, detailing our current understanding of the pathophysiology and outlining both the clinical manifestations of individual pain states and the treatment options available. PMID:26516548

  16. Evolutionary biology of cancer.

    Science.gov (United States)

    Crespi, Bernard; Summers, Kyle

    2005-10-01

    Cancer is driven by the somatic evolution of cell lineages that have escaped controls on replication and by the population-level evolution of genes that influence cancer risk. We describe here how recent evolutionary ecological studies have elucidated the roles of predation by the immune system and competition among normal and cancerous cells in the somatic evolution of cancer. Recent analyses of the evolution of cancer at the population level show how rapid changes in human environments have augmented cancer risk, how strong selection has frequently led to increased cancer risk as a byproduct, and how anticancer selection has led to tumor-suppression systems, tissue designs that slow somatic evolution, constraints on morphological evolution and even senescence itself. We discuss how applications of the tools of ecology and evolutionary biology are poised to revolutionize our understanding and treatment of this disease.

  17. Lung Cancer Stem Cells

    Directory of Open Access Journals (Sweden)

    Sharon R. Pine

    2008-01-01

    Full Text Available Lung cancer remains a major cause of cancer-related lethality because of high incidence and recurrence in spite of significant advances in staging and therapies. Recent data indicates that stem cells situated throughout the airways may initiate cancer formation. These putative stem cells maintain protumorigenic characteristics including high proliferative capacity, multipotent differentiation, drug resistance and long lifespan relative to other cells. Stem cell signaling and differentiation pathways are maintained within distinct cancer types, and destabilization of this machinery may participate in maintenance of cancer stem cells. Characterization of lung cancer stem cells is an area of active research and is critical for developing novel therapies. This review summarizes the current knowledge on stem cell signaling pathways and cell markers used to identify the lung cancer stem cells.

  18. Genital Cancers in Women: Vulvar Cancer.

    Science.gov (United States)

    Hill-Daniel, Jamie; Roett, Michelle A

    2015-11-01

    Vulvar cancer is uncommon, accounting for 0.3% of all new US cancer diagnoses. The majority of cases are squamous cell carcinoma. Malignant melanoma is the second most common type. Other cases are related to chronic inflammatory skin disorders such as lichen sclerosus. Vulvar intraepithelial neoplasia (VIN) is a precursor to squamous cell vulvar cancer. It may be the usual type associated with human papillomavirus (HPV) infection, or the differentiated type often associated with chronic skin disorders. Risk factors for VIN are HPV infection, cigarette smoking, chronic skin disorders, and immunosuppression. Symptoms of vulvar cancer include pruritus, bleeding, skin color change, skin lesions, and dysuria. VIN and vulvar cancer are diagnosed by skin biopsy. Treatment of VIN includes wide local excision, via surgical removal or with laser or ultrasonic surgical aspiration procedures. Medical therapy with imiquimod also may be used. Prognosis is good with early detection; the 5-year survival rate for stage I cancer is greater than 85%. Advanced disease has a poor prognosis, with a 5-year survival rate in stage IV disease as low as 5%. Although screening for vulvar cancer is not recommended, clinicians should evaluate and biopsy any suspicious vulvar lesions. Current efforts at prevention are aimed at HPV vaccination. PMID:26569049

  19. Familial pancreatic cancer.

    Science.gov (United States)

    Klein, A P; Hruban, R H; Brune, K A; Petersen, G M; Goggins, M

    2001-01-01

    Pancreatic cancer is the fourth leading cause of cancer death in both men and women in the United States and will be responsible for an estimated 28,900 deaths in 2001. Relatively little is known of its etiology, and the only well-established risk factor is cigarette smoking. Studies over the past 3 decades have shown that 4%-16% of patients with pancreatic cancer have a family history of the disease. A small fraction of this aggregation can be accounted for in inherited cancer syndromes, including familial atypical multiple-mole melanoma, Peutz-Jeghers syndrome, hereditary breast-ovarian cancer, hereditary pancreatitis, and hereditary nonpolyposis colorectal cancer. These syndromes arise as a result of germline mutations in the BRCA2, pl6 (familial atypical multiple-mole melanoma), mismatch repair (hereditary nonpolyposis colorectal cancer), and STK11 (Peutz-Jeghers syndrome) genes. In addition, hereditary plays a role in predisposing certain patients with apparently sporadic pancreatic cancer. Many patients with pancreatic cancers caused by a germline mutation in a cancer-causing gene do not have a pedigree that is suggestive of a familial cancer syndrome. A recent prospective analysis of the pedigrees in the National Familial Pancreatic Tumor Registry found that individuals with a family history of pancreatic cancer in multiple first-degree relatives have a high risk of pancreatic cancer themselves. The identification of such high-risk individuals will help clinicians target screening programs and develop preventive interventions with the hope of reducing the mortality of pancreatic cancer in these families.

  20. Cancer Therapy Evaluation Program | Office of Cancer Genomics

    Science.gov (United States)

    The Cancer Therapy Evaluation Program (CTEP) seeks to improve the lives of cancer patients by finding better treatments, control mechanisms, and cures for cancer. CTEP funds a national program of cancer research, sponsoring clinical trials to evaluate new anti-cancer agents.