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A lung cancer survivor shares her story about diagnosis, treatment, and community support. She also gives advice for other cancer survivors. Created: 10/20/2016 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP). Date Released: 10/20/2016.
Kurita, Geana Paula; Sjøgren, Per
BACKGROUND: The number of patients surviving cancer disease has increased in last decades. Consequently, an emerging population with different needs due to long-term or late effects of cancer disease and/or treatment, e.g. chronic pain, is of major concern. EPIDEMIOLOGY: Chronic pain is one...... survivors. Pain management strategies are discussed according to the biopsychosocial model and with the rapidly growing number of cancer survivors the establishment of multidisciplinary clinics as a part of comprehensive cancer centers are proposed....
This paper reviews nutritional issues related to cancer treatment and further explores nutritional needs pertinent to cancer survivorship. It examines the major problems with nutrition when patients undergo the main cancer treatment modalities of chemotherapy, radiotherapy and surgery. Particular attention is paid to long-term dietary advice in acknowledgement of the improved effectiveness of cancer treatment and the chronic nature of the condition.
Harrop, J Phil; Dean, Julie A; Paskett, Electra D
The number of cancer survivors and the amount of cancer survivorship research have grown substantially during the past three decades. This article provides a review of interventional and observational cancer survivorship research efforts as well as a summary of current cancer survivorship research projects being conducted by National Cancer Institute-designated cancer centers in an effort to identify areas that need further attention.
Breast cancer is the most common female cancer and globally remains a major public health concern. The diagnosis and treatment of breast cancer continues to develop. Diagnosis is now more precise, surgery is less mutilating and women now have the option of breast conserving therapy with better cosmesis, and without sacrificing survival. Radiotherapy is more targeted and the selection of patients for adjuvant chemotherapy is based not only on prognostic and predictive factors, but also on newer molecular profiling that will ensure that chemotherapy is given to the patients who need and respond to it. These developments all provide a more tailored approach to the treatment of breast cancer. Management now involves a multidisciplinary team approach in order to provide the highest standard of care for patients throughout their cancer journey from diagnosis through treatment and into follow-up care.
McCollum, Kennon H; Wood, Felecia G; Auriemma, Kimberly
This article describes a cancer survivorship program that addressed quality of life (QOL) changes related to chemotherapy. The program focused on adult breast and colon cancer survivors at a community oncology practice in the southeastern United States, and consisted of an educational visit designed to identify and address QOL changes that occurred as a result of chemotherapy. The QOL of Cancer Survivors (QOL-CS) survey administered before and after the visit analyzed QOL metrics, which were combined with program evaluation data to assess physical, psychosocial, social, and spiritual well-being changes that may have occurred as a result of program participation. Differences in QOL-CS scores did not represent statistically significant changes in QOL for program participants. However, program evaluation responses identified perceived changes in QOL as a result of participating in cancer treatment and a subsequent cancer survivorship program, which demonstrated clinical significance for program participants. Physical, psychosocial, social, and spiritual well-being measures were affected by program participation. Improvement in distress related to the initial cancer diagnosis and family distress were the most significant reported changes, and male gender and advanced age were associated with improved psychosocial well-being.
Jones, Lee W
A lung cancer diagnosis and associated therapeutic management is associated with unique and varying degrees of adverse physical/functional impairments that dramatically reduce a patient's ability to tolerate exercise. Poor exercise tolerance predisposes to increased susceptibility to other common age-related diseases, poor quality of life (QOL), and likely premature death. Here we review the putative literature investigating the role of exercise as an adjunct therapy across the lung cancer continuum (i.e., diagnosis to palliation). The current evidence suggests that exercise training is a safe and feasible adjunct therapy for operable lung cancer patients both before and after pulmonary resection. Among patients with inoperable disease, feasibility and safety studies of carefully prescribed exercise training are warranted. Preliminary evidence in this area supports that exercise therapy may be an important consideration in multidisciplinary management of patients diagnosed with lung cancer.
Pinto, Bernardine M; Ciccolo, Joseph T
Physical activity (PA) participation has been shown to be helpful in improving physical and mental well-being among cancer survivors. The purpose of this chapter is to review the literature on the determinants of physical activity motivation and behavior among cancer survivors. Using theories of behavior change, researchers have sought to identify the correlates of motivation that predict the participation in regular physical activity in observational studies, while intervention studies have focused on manipulating those factors to support the initiation of physical activity. The majority of this work has been conducted with breast cancer survivors, and there is an interest in expanding this work to survivors of others cancers (e.g., prostate, lung, and colorectal cancer). Results suggest that constructs from the Theory of Planned Behavior (TPB), Transtheoretical Model (TTM), and Social Cognitive Theory (SCT) are associated with greater motivation for physical activity, and some of these constructs have been used in interventions to promote physical activity adoption. There is scope for understanding the determinants of physical activity adoption in various cancer survivor populations. Much more needs to done to identify the determinants of maintenance of physical activity.
Anthony J. Bazzan
Full Text Available The primary goal of palliative cancer care is typically to relieve suffering and improve quality of life. Most approaches to diet in this setting have focused only on eating as many calories as possible to avoid cachexia. However, as the concept of palliative care has evolved to include all aspects of cancer survivorship and not just end of life care, there is an increasing need to thoughtfully consider diet and nutrition approaches that can impact not only quality of life but overall health outcomes and perhaps even positively affect cancer recurrence and progression. In this regard, there has been a recent emphasis in the literature on nutrition and cancer as an important factor in both quality of life and in the pathophysiology of cancer. Hence, the primary purpose of this paper is to review the current data on diet and nutrition as it pertains to a wide range of cancer patients in the palliative care setting.
Travis, Lois B.; Beard, Clair; Allan, James M.; Dahl, Alv A.; Feldman, Darren R.; Oldenburg, Jan; Daugaard, Gedske; Kelly, Jennifer L.; Dolan, M. Eileen; Hannigan, Robyn; Constine, Louis S.; Oeffinger, Kevin C.; Okunieff, Paul; Armstrong, Greg; Wiljer, David; Miller, Robert C.; Gietema, Jourik A.; van Leeuwen, Flora E.; Williams, Jacqueline P.; Nichols, Craig R.; Einhorn, Lawrence H.; Fossa, Sophie D.
Testicular cancer represents the most curable solid tumor, with a 10-year survival rate of more than 95%. Given the young average age at diagnosis, it is estimated that effective treatment approaches, in particular, platinum-based chemotherapy, have resulted in an average gain of several decades of
Dunn, J; Casey, C; Sandoe, D; Hyde, M K; Cheron-Sauer, M-C; Lowe, A; Oliffe, J L; Chambers, S K
Across Australia, prostate cancer support groups (PCSG) have emerged to fill a gap in psychosocial care for men and their families. However, an understanding of the triggers and influencers of the PCSG movement is absent. We interviewed 21 SG leaders (19 PC survivors, two partners), of whom six also attended a focus group, about motivations, experiences, past and future challenges in founding and leading PCSGs. Thematic analysis identified four global themes: illness experience; enacting a supportive response; forming a national collective and challenges. Leaders described men's feelings of isolation and neglect by the health system as the impetus for PCSGs to form and give/receive mutual help. Negotiating health care systems was an early challenge. National affiliation enabled leaders to build a united voice in the health system and establish a group identity and collective voice. Affiliation was supported by a symbiotic relationship with tensions between independence, affiliation and governance. Future challenges were group sustainability and inclusiveness. Study findings describe how a grassroots PCSG movement arose consistent with an embodied health movement perspective. Health care organisations who seek to leverage these community resources need to be cognisant of SG values and purpose if they are to negotiate effective partnerships that maximise mutual benefit.
Full Text Available Cancer survivorship research includes the study of physical, psychosocial, and economic consequences of cancer diagnosis and treatment among pediatric and adult cancer survivors. Historically, the majority of cancer survivorship studies were from the United States, but survivorship issues are increasingly being addressed in other developed countries. Cross-cultural studies remain, however, scarce. The degree to which knowledge attained may or may not be transferred across cultures, countries, or regions is not known. Some important challenges for comparative research are therefore discussed in a cross-cultural perspective. Several substantive and methodological challenges that complicate the execution of cross-cultural cancer survivorship research are presented with examples and discussed to facilitate comparative research efforts in the establishment of new survivorship cohorts and in the planning and implementation of survivorship studies. Comparative research is one key to understanding the nature of cancer survivorship, distinguishing modifiable from nonmodifiable factors at individual, hospital, societal, and system levels and may thus guide appropriate interventions. Lastly, suggested future courses of action within the field of comparative cancer survivorship research are provided.
Bhatia, Smita; Armenian, Saro H; Armstrong, Gregory T; van Dulmen-den Broeder, Eline; Hawkins, Michael M; Kremer, Leontien C M; Kuehni, Claudia E; Olsen, Jørgen H; Robison, Leslie L; Hudson, Melissa M
Survivors of childhood cancer carry a substantial burden of morbidity and are at increased risk for premature death. Furthermore, clear associations exist between specific therapeutic exposures and the risk for a variety of long-term complications. The entire landscape of health issues encountered for decades after successful completion of treatment is currently being explored in various collaborative research settings. These settings include large population-based or multi-institutional cohorts and single-institution studies. The ascertainment of outcomes has depended on self-reporting, linkage to registries, or clinical assessments. Survivorship research in the cooperative group setting, such as the Children's Oncology Group, has leveraged the clinical trials infrastructure to explore the molecular underpinnings of treatment-related adverse events, and to understand specific complications in the setting of randomized risk-reduction strategies. This review highlights the salient findings from these large collaborative initiatives, emphasizing the need for life-long follow-up of survivors of childhood cancer, and describing the development of several guidelines and efforts toward harmonization. Finally, the review reinforces the need to identify populations at highest risk, facilitating the development of risk prediction models that would allow for targeted interventions across the entire trajectory of survivorship.
Adams, Natasia; Gisiger-Camata, Silvia; Hardy, Claudia M; Thomas, Tammi F; Jukkala, Angela; Meneses, Karen
Disparities in cancer survivorship exist among specific populations of breast cancer survivors, specifically rural African American breast cancer survivors (AA-BCS). While effective survivorship interventions are available to address and improve quality of life, interventions must be culturally tailored for relevance to survivors. Here, we report the results of our formative research using focus groups and in-depth interview to better understand unique rural AA-BCS survivorship experiences and needs in the Alabama Black Belt. Surveys were used to gather sociodemographic and cancer treatment data. Fifteen rural AA-BCS shared their experiences and concerns about keeping their cancer a secret, lack of knowledge about survivorship, lingering symptoms, religion and spirituality, cancer surveillance, and general lack of survivorship education and support. Rural AA-BCS were unwilling to share their cancer diagnosis, preferring to keep it a secret to protect family and friends. Quality-of-life issues like lymphedema body image and sexuality were not well understood. They viewed spirituality and religion as essential in coping and accepting cancer. Participants also discussed the importance of and barriers to maintaining health through regular check-ups. They needed social support from family and friends and health care providers. Overall, rural AA-BCS expressed their need for knowledge about survivorship self-management by providing a vivid picture of the realities of cancer survival based on shared concerns for survivorship support and education within the context of culture.
Berg, Carla; Stratton, Erin; Esiashvili, Natia; Mertens, Ann; Vanderpool, Robin C
We examined healthcare providers' perceptions of the goals of survivorship care and survivor programs, systems-level barriers and individual patient-level barriers to engaging patients in survivorship care, and potential resources for increasing engagement. In 2012, we recruited 21 healthcare providers of young adult survivors of childhood cancers from a children's hospital and a cancer center in the Southeastern USA to complete telephone-based semi-structured interviews. The sample was 45.95 years old (SD = 7.57) on average, 52.4 % female, and 81.0 % MDs. The major goals of survivorship programs identified were medical care management (e.g., addressing late and long-term effects, providing survivorship care plans (SCPs), assisting in transition of care) and holistic care including addressing psychosocial issues and promoting healthy lifestyles. Systems-level barriers to engagement in survivorship care included limited resources (e.g., time), role confusion (e.g., within cancer centers, from treatment team to survivorship care, role of primary care providers), communication challenges within the medical system (e.g., limited tracking of patients, lack of understanding of the role of survivorship clinic), communication challenges with patients (e.g., setting expectations regarding transition to survivorship care), and lack of insurance coverage. Perceived patient-level factors included psychological barriers (e.g., fear, avoidance), resistance to survivorship care, and physical barriers (e.g., distance from survivorship clinics). Resources to address these barriers included increased access to information, technology-based resources, and ensuring valuable services. There are several systems-level and patient-level barriers to survivorship care, thus requiring multilevel interventions to promote engagement in care among young adult survivors of childhood cancer.
Luta, Gheorghe; Sheppard, Vanessa; Isaacs, Claudine; Cohen, Harvey J.; Muss, Hyman B.; Yung, Rachel; Clapp, Jonathan D.; Winer, Eric; Hudis, Clifford; Tallarico, Michelle; Wang, Julhy; Barry, William T.; Mandelblatt, Jeanne S.
Purpose Survivorship care plans (SCP) are recommended for all cancer patients and could be especially useful to survivors 65 years and over (“older”). This study examined receipt of SCPs among older breast cancer survivors and whether SCPs were associated with improved patient-reported outcomes. Methods Three hundred and twenty-eight older women diagnosed with invasive, nonmetastatic breast cancer between 2007–2011 were recruited from 78 cooperative-group sites. Participants completed telephone interviews at baseline and 1-year posttreatment. Regression analyses examined SCP receipt (yes/no) and functioning (EORTC-QLQ-C30), cancer worry, and experiences of survivorship care (care coordination, knowledge). Results Only 35 % of women received SCPs. For each 1-year increase in age, there was a 5 % lower odds of receiving an SCP (odds ratio (OR)=0.94, 95 % confidence interval (CI) 0.91–0.98, p=0.007). Besides age, no other factor predicted SCPs. SCP receipt was associated with greater knowledge and understanding of requisite follow-up care (p<0.05); however, functioning was not significantly different among those with vs. without SCPs. Conclusions Receipt of care plans was limited. SCPs improved understanding of breast cancer follow-up care among older survivors, but did not impact functioning one year post-treatment. Implications for Cancer Survivors To impact functioning and salient needs of the growing cohort of older survivors, survivorship care plans likely should be tailored to geriatric-specific issues. To improve functioning, SCP content should expand to include exercise, nutrition, polypharmacy, social support and management of symptom burden from cancer, and other comorbid conditions. To improve follow-up care for cancer survivors, SCPs should delineate shared care roles between oncology and primary care in managing recurrence surveillance, screening, and cancer sequelae. PMID:24917307
Fabian, Carol J; Kimler, Bruce F; Hursting, Stephen D
Women with evidence of high intake ratios of the marine omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) relative to the omega-6 arachidonic acid have been found to have a reduced risk of breast cancer compared with those with low ratios in some but not all case-control and cohort studies. If increasing EPA and DHA relative to arachidonic acid is effective in reducing breast cancer risk, likely mechanisms include reduction in proinflammatory lipid derivatives, inhibition of nuclear factor-κB-induced cytokine production, and decreased growth factor receptor signaling as a result of alteration in membrane lipid rafts. Primary prevention trials with either risk biomarkers or cancer incidence as endpoints are underway but final results of these trials are currently unavailable. EPA and DHA supplementation is also being explored in an effort to help prevent or alleviate common problems after a breast cancer diagnosis, including cardiac and cognitive dysfunction and chemotherapy-induced peripheral neuropathy. The insulin-sensitizing and anabolic properties of EPA and DHA also suggest supplementation studies to determine whether these omega-3 fatty acids might reduce chemotherapy-associated loss of muscle mass and weight gain. We will briefly review relevant omega-3 fatty acid metabolism, and early investigations in breast cancer prevention and survivorship.
Guerard, Emily J; Nightingale, Ginah; Bellizzi, Keith; Burhenn, Peggy; Rosko, Ashley; Artz, Andrew S; Korc-Grodzicki, Beatriz; Canin, Beverly; Dale, William; Ferrell, Betty
Older adult cancer survivors currently account for almost 60% of all cancer survivors. The number of older cancer survivors will continue to increase as the population ages and as patients' live longer after a cancer diagnosis. As part of cancer center accreditation, the American College of Surgeons Commission on Cancer® (CoC) has placed great importance on survivorship care planning. While the CoC has set standards for general survivorship care, there is sparse evidence on how to best care for older adult cancer survivors. Concern exists among the medical community that survivorship care plans could increase paperwork without improving outcomes. Given the diverse and unique needs of older adult cancer survivors, the inter-professional team provides a structure and process for survivorship care built around the particular needs of older adults. The Cancer and Aging Research Group (CARG), in partnership with the NIA/NCI, held a U13 conference in May 2015 in part to discuss survivorship care for older adults with cancer. This report discusses four themes that emerged from one section of the conference: (1) survivorship care is a process that continually evolves to meet the needs of older adults; (2) older adult cancer survivors have unique needs and care plans should be tailored to meet these needs; (3) the inter-professional team is ideally suited to structure survivorship care of older adults; (4) patient advocacy must be encouraged throughout the cancer care continuum. As evidence based survivorship practices develop, the unique needs of older adults need to be given substantial attention.
Elizabeth Charlotte Moser
In 2012, the European Organisation of Research and Treatment of Cancer (EORTC Survivorship Task Force was created to focus research efforts on late morbidity of cancer treatment and its impact on society. On 30–31st January 2014, the 1st EORTC Cancer Survivorship Summit was organised to facilitate interaction between clinicians, researchers, social workers, patients, insurers, bankers and policy makers. This important event addressed the needs of cancer survivors, and new collaborations between academic groups, patient advocates, financial and political representatives were formed to guide future European research and health policies in this field. This special issue of the European Journal of Cancer is entirely dedicated to this Summit and addresses, respectively, second malignancies, cardiovascular disease, cognitive dysfunction, infertility/sexuality and psycho-social problems following cancer treatment.
Mellon, S; Northouse, L L
The objectives of this study were: (a) to examine the quality of life of the family as a unit during the long-term survivor phase of illness and (b) to test a family model of factors that may influence family quality of life. The family survivorship model, which includes illness survival stressors (family stressors, fear of recurrence, and patient somatic concerns), resources (family hardiness and family social support), appraisal (family meaning of the illness), and the outcome, family quality of life, was used to guide this exploratory cross-sectional study. A random, stratified sample of 123 families (N = 246 individuals) was interviewed 1-5 years after treatment ended. The model explained 63% of the variance in family quality of life, with the strongest predictors being concurrent family stressors, family social support, family member fear of recurrence, family meaning of the illness, and patient employment status. The study findings suggest the importance of addressing cancer-related stressors, family resources, and family meaning as key factors related to family quality of life.
de Guzman, Allan B; Jimenez, Benito Christian B; Jocson, Kathlyn P; Junio, Aileen R; Junio, Drazen E; Jurado, Jasper Benjamin N; Justiniano, Angela Bianca F
Considering the paucity of studies dealing with the holistic aspect of the cancer experience, this grounded theory study seeks to conceptualize the process of cancer survivorship among Filipinos. Twenty-seven Filipino cancer survivors were purposively selected, and a two-part instrument, specifically robotfoto and focus group interviews, was used to gather data. The Glaserian method of grounded theory analysis was used, and extended texts were analyzed inductively via a dendrogram. Member checking and correspondence were observed to validate the surfacing stages, leading to the conceptualization of a theoretical model termed as the Ribbon of Cancer Survivorship. The said model describes the trifling (living before), transfusing (accepting the reality), transforming (being strong), and transcending (living beyond) phases of cancer survivorship. Ten interesting substages were also identified, namely: tainting, desolating, disrupting, and embracing for the transfusing phase; tormenting, distressing, awakening, and transfiguring for the transforming phase, and trembling and enlivening for the transcending phase. The resulting theoretical model has clearly and successfully described the entire process of cancer survivorship among Filipinos. It is hoped that the model be used as a reference for future studies about cancer survivorship and as a guide for nurses in providing a more empathetic care among cancer patients.
Schubart, Jane R.; Gusani, Niraj J.; Kass, Rena; Lewis, Peter
With the increasing survival of cancer patients, primary care residents must be familiar with the late effects of cancer treatment and be able to offer appropriate survivorship care in partnership with cancer care specialists. To address these paired public health and educational needs, an interdisciplinary group at our institution is developing,…
Sherri G. Homan
Full Text Available Breast cancer survivors are at risk of developing a second primary cancer. Colorectal cancer (CRC is one of the leading second primary cancers, and it is often preventable. We developed a multi-component educational tool to inform and encourage women breast cancer survivors to engage in CRC screening. To assess the strengths and weakness of the tool and to improve the relevancy to the target audience, we convened four focus groups of women breast cancer survivors in Missouri. We also assessed the potential impact of the tool on the knowledge, attitudes, and beliefs regarding CRC and collected information on the barriers to CRC screening through pre- and post-focus groups’ questionnaires. A total of 43 women breast cancer survivors participated and provided very valuable suggestions on design and content to update the tool. Through the process and comparing pre- and post-focus group assessments, a significantly higher proportion of breast cancer survivors strongly agreed or agreed that CRC is preventable (78.6% vs. 96.9%, p = 0.02 and became aware that they were at a slightly increased risk for CRC (18.6% vs. 51.7%, p = 0.003. The most cited barrier was the complexity of preparation for colonoscopy.
cancers (n = 86); genitourinary/gastrointestinal (n = 118); and other cancers (breast, reproductive , blood, bone, unspecified/unknown) (n = 118) (see...overdispersed Poisson, and negative binomial models. Psychol Bull 118:392-404 60. Glass AS, Cary KC, Cooperberg MR. 2013. Risk-based prostate cancer... Reproductive , Other/Unknown) 118 30.0 63 Table 4. Length of Cancer Survivorship Survival Time from Cancer Diagnosis (months) Survival
Full Text Available Objective: This study aims to assess the knowledge of definition of cancer survivors among Japanese oncology nurses and their roles in long-term cancer survivorship care. Methods: A structured self-administered and self-report questionnaire created by the study investigators was given to members of the Japanese Society of Cancer Nursing. The subjects were 81 female oncology nurses. Results: Forty-nine nurses had 11 or more years of nursing experience, while 27 nurses had cancer-related nursing certifications such as, certification in oncology nursing specialist. This study population had rather rich experience in oncology nursing. Sixty-two nurses defined a cancer survivor from the time of diagnosis, while the nurses′ recognition of long-term survivorship care was poor, compared with nursing care at the time of diagnosis, during treatment, and end of life. Conclusions: The nurses were aware of the needs to recognize and address issues faced by long-term cancer survivors and for nursing study, but very few put the effective patient education and interventions into practice. It is because oncology nurses have few chances to see cancer survivors who go out of the hands of healthcare professionals. In increasing the number of long-term survivors, long-term survivorship care is needed in addition to incorporating such education into undergraduate and graduate programs. Further study on the knowledge of long-term cancer survivorship care and nursing practices are required.
Jennifer M. Hulett
Full Text Available This study explored breast cancer survivors’ perspectives regarding their experiences of the survivorship continuum from diagnosis through 30 months post-treatment. The sample included women (N = 379 with newly-diagnosed breast cancer undergoing treatment at a Midwestern university-affiliated cancer center. Semi-structured interviews were conducted using the Lymphedema and Breast Cancer Questionnaire at time of diagnosis, post-operatively, quarterly during the first year, and then semi-annually thereafter through 30 months post-treatment. A mixed-methodology was used to analyze participants’ comments. Themes central to long-term survivorship experiences included social support, positive worldviews, breast cancer and lymphedema health literacy, religious/spiritual beliefs, self-empowerment, and recovery expectations. These themes were consistent with a psychoneuroimmunological model of health in which psychosocial variables mediate stress and influence health outcomes. Qualitative data showed that social support and positive worldviews were the two themes with the most significant impact on long-term breast cancer survivorship experiences. Survivors expressed a need to advance their health care literacy in order to share ownership of breast cancer and lymphedema treatment decisions. Since breast cancer is an immune-mediated disease, long-term survivorship planning should address psychosocial factors that influence the long-term psychological distress associated with immune dysfunction.
Runowicz, Carolyn D; Leach, Corinne R; Henry, N Lynn; Henry, Karen S; Mackey, Heather T; Cowens-Alvarado, Rebecca L; Cannady, Rachel S; Pratt-Chapman, Mandi L; Edge, Stephen B; Jacobs, Linda A; Hurria, Arti; Marks, Lawrence B; LaMonte, Samuel J; Warner, Ellen; Lyman, Gary H; Ganz, Patricia A
Answer questions and earn CME/CNE The purpose of the American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline is to provide recommendations to assist primary care and other clinicians in the care of female adult survivors of breast cancer. A systematic review of the literature was conducted using PubMed through April 2015. A multidisciplinary expert workgroup with expertise in primary care, gynecology, surgical oncology, medical oncology, radiation oncology, and nursing was formed and tasked with drafting the Breast Cancer Survivorship Care Guideline. A total of 1073 articles met inclusion criteria; and, after full text review, 237 were included as the evidence base. Patients should undergo regular surveillance for breast cancer recurrence, including evaluation with a cancer-related history and physical examination, and should be screened for new primary breast cancer. Data do not support performing routine laboratory tests or imaging tests in asymptomatic patients to evaluate for breast cancer recurrence. Primary care clinicians should counsel patients about the importance of maintaining a healthy lifestyle, monitor for post-treatment symptoms that can adversely affect quality of life, and monitor for adherence to endocrine therapy. Recommendations provided in this guideline are based on current evidence in the literature and expert consensus opinion. Most of the evidence is not sufficient to warrant a strong evidence-based recommendation. Recommendations on surveillance for breast cancer recurrence, screening for second primary cancers, assessment and management of physical and psychosocial long-term and late effects of breast cancer and its treatment, health promotion, and care coordination/practice implications are made.
Christensen, Jesper F; Bandak, Mikkel; Campbell, Anna
-induced cardiovascular dysfunction to prevent premature onset of clinical cardiovascular disease in germ cell cancer survivors, with a view towards highlighting future directions of exercise-based survivorship research in the germ cell cancer setting. CONCLUSION: As exercise training may have the potential to ameliorate...... and/or reverse long-term cardiovascular disease sequelae in germ cell cancer survivors, a strong rationale exists for the promotion of exercise oncology research in this setting, in order to provide exercise recommendations for optimal germ cell cancer survivorship......., are subjected to toxicities, which individually, and synergistically, can cause physiological impairments leading to sub-clinical or clinical cardiovascular disorders (i.e. the 'multiple-hit hypothesis'). Furthermore, we discuss the efficacy and utility of structured exercise training to ameliorate treatment...
Runowicz, Carolyn D; Leach, Corinne R; Henry, N Lynn; Henry, Karen S; Mackey, Heather T; Cowens-Alvarado, Rebecca L; Cannady, Rachel S; Pratt-Chapman, Mandi L; Edge, Stephen B; Jacobs, Linda A; Hurria, Arti; Marks, Lawrence B; LaMonte, Samuel J; Warner, Ellen; Lyman, Gary H; Ganz, Patricia A
The purpose of the American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline is to provide recommendations to assist primary care and other clinicians in the care of female adult survivors of breast cancer. A systematic review of the literature was conducted using PubMed through April 2015. A multidisciplinary expert workgroup with expertise in primary care, gynecology, surgical oncology, medical oncology, radiation oncology, and nursing was formed and tasked with drafting the Breast Cancer Survivorship Care Guideline. A total of 1,073 articles met inclusion criteria; and, after full text review, 237 were included as the evidence base. Patients should undergo regular surveillance for breast cancer recurrence, including evaluation with a cancer-related history and physical examination, and should be screened for new primary breast cancer. Data do not support performing routine laboratory tests or imaging tests in asymptomatic patients to evaluate for breast cancer recurrence. Primary care clinicians should counsel patients about the importance of maintaining a healthy lifestyle, monitor for post-treatment symptoms that can adversely affect quality of life, and monitor for adherence to endocrine therapy. Recommendations provided in this guideline are based on current evidence in the literature and expert consensus opinion. Most of the evidence is not sufficient to warrant a strong evidence-based recommendation. Recommendations on surveillance for breast cancer recurrence, screening for second primary cancers, assessment and management of physical and psychosocial long-term and late effects of breast cancer and its treatment, health promotion, and care coordination/practice implications are made.This guideline was developed through a collaboration between the American Cancer Society and the American Society of Clinical Oncology and has been published jointly by invitation and consent in both CA: A Cancer Journal for
Lu, Yani; John, Esther M; Sullivan-Halley, Jane; Vigen, Cheryl; Gomez, Scarlett Lin; Kwan, Marilyn L; Caan, Bette J; Lee, Valerie S; Roh, Janise M; Shariff-Marco, Salma; Keegan, Theresa H M; Kurian, Allison W; Monroe, Kristine R; Cheng, Iona; Sposto, Richard; Wu, Anna H; Bernstein, Leslie
Recent epidemiologic evidence suggests that prediagnosis physical activity is associated with survival in women diagnosed with breast cancer. However, few data exist for racial/ethnic groups other than non-Latina whites. To examine the association between prediagnosis recreational physical activity and mortality by race/ethnicity, we pooled data from the California Breast Cancer Survivorship Consortium for 3 population-based case-control studies of breast cancer patients (n=4,608) diagnosed from 1994 to 2002 and followed up through 2010. Cox proportional hazards models provided estimates of the relative hazard ratio for mortality from all causes, breast cancer, and causes other than breast cancer associated with recent recreational physical activity (i.e., in the 10 years before diagnosis). Among 1,347 ascertained deaths, 826 (61%) were from breast cancer. Compared with women with the lowest level of recent recreational physical activity, those with the highest level had a marginally decreased risk of all-cause mortality (hazard ratio=0.88, 95% confidence interval: 0.76, 1.01) and a statistically significant decreased risk of mortality from causes other than breast cancer (hazard ratio=0.63, 95% confidence interval: 0.49, 0.80), and particularly from cardiovascular disease. No association was observed for breast cancer-specific mortality. These risk patterns did not differ by race/ethnicity (non-Latina white, African American, Latina, and Asian American). Our findings suggest that physical activity is beneficial for overall survival regardless of race/ethnicity.
Napoles, Tessa M.; Banks, Priscilla J.; Orenstein, Fern S.; Luce, Judith A.; Joseph, Galen
Purpose Despite the Institute of Medicine’s (IOM) 2005 recommendation, few care organizations have instituted standard survivorship care plans (SCPs). Low health literacy and low English proficiency are important factors to consider in SCP development. Our study aimed to identify information needs and survivorship care plan preferences of low literacy, multi-lingual patients to support the transition from oncology to primary care and ongoing learning in survivorship. Methods We conducted focus groups in five languages with African American, Latina, Russian, Filipina, White, and Chinese medically underserved breast cancer patients. Topics explored included the transition to primary care, access to information, knowledge of treatment history, and perspectives on SCPs. Results Analysis of focus group data identified three themes: 1) the need for information and education on the transition between “active treatment” and “survivorship”; 2) information needed (and often not obtained) from providers; and 3) perspectives on SCP content and delivery. Conclusions Our data point to the need to develop a process as well as written information for medically underserved breast cancer patients. An SCP document will not replace direct communication with providers about treatment, symptom management and transition, a communication that is missing in participating safety-net patients’ experiences of cancer care. Women turned to peer support and community-based organizations in the absence of information from providers. Implications for Cancer Survivors “Clear and effective” communication of survivorship care for safety-net patients requires dedicated staff trained to address wide-ranging information needs and uncertainties. PMID:27992491
Full Text Available To investigate the recent trends in definitive management of esophageal cancer, the records of 138 consecutive patients treated with radical intent in a single institution between 1995 and 2003 were reviewed and analyzed. The median follow-up period was 5.7 years (range 1.1 to 10.4 years. Seventy-seven patients were treated with radiation therapy (RT only and 61 with combined regimens (CRT, in which RT was combined with either radical surgery or chemotherapy, or both. The overall survival of the entire cohort was 32% over two years and 20% over five years. The survivorship in the RT group was 17% over two years and 5% over five years. In the CRT group, 51% and 35% survived over two and five years, respectively. From all the potential prognostic factors examined by univariate and multivariate analyses, only male sex and use of CRT were strongly associated with better survivorship. There was no significant difference in the outcomes among the different regimens of CRT. Survivorship was not affected by the location or histology of the tumour, clinical stage, dose of RT or use of endoluminal brachytherapy in addition to external beam RT. There was a greater tendency to use RT only more often in older patients, but patient age did not affect survivorship. The proportion of patients treated with CRT did not change significantly over the last versus the first four years of the observed period. Combined regimens are undoubtedly superior to RT as a single modality. The long-term survivorship of patients in a subgroup of our patients treated with combined modality protocols compared favourably with the previously reported results in the literature and specifically in prospective randomized trials. However, the optimal combined modality regimen is yet to be defined.
Howell, D.; Hack, T.F.; Oliver, T.K.; Chulak, T.; Mayo, S.; Aubin, M.; Chasen, M.; Earle, C.C.; Friedman, A.J.; Green, E.; Jones, G.W.; Jones, J.M.; Parkinson, M.; Payeur, N.; Sabiston, C.M.; Sinclair, S.
Objective Our goal was to develop evidence-based recommendations for the organization and structure of cancer survivorship services, and best-care practices to optimize the health and well-being of post–primary treatment survivors. This review sought to determine the optimal organization and care delivery structure for cancer survivorship services, and the specific clinical practices and interventions that would improve or maximize the psychosocial health and overall well-being of adult cancer survivors. Data Sources We conducted a systematic search of the Inventory of Cancer Guidelines at the Canadian Partnership Against Cancer, the U.S. National Guideline Clearinghouse, the Canadian Medical Association InfoBase, medline (ovid: 1999 through November 2009), embase (ovid: 1999 through November 2009), Psychinfo (ovid: 1999 through November 2009), the Cochrane Library (ovid; Issue 1, 2009), and cinahl (ebsco: 1999 through December 2009). Reference lists of related papers and recent review articles were scanned for additional citations. Methods Articles were selected for inclusion as evidence in the systematic review if they reported on organizational system components for survivors of cancer, or on psychosocial or supportive care interventions HOWELL et al. designed for survivors of cancer. Articles were excluded from the systematic review if they focused only on pediatric cancer survivor populations or on populations that transitioned from pediatric cancer to adult services; if they addressed only pharmacologic interventions or diagnostic testing and follow-up of cancer survivors; if they were systematic reviews with inadequately described methods; if they were qualitative or descriptive studies; and if they were opinion papers, letters, or editorials. Data Extraction and Synthesis Evidence was selected and reviewed by three members of the Cancer Journey Survivorship Expert Panel (SM, TC, TKO). The resulting summary of the evidence was guided further and reviewed
Pam Bryant, a breast cancer survivor, talks about her personal journey and how being diagnosed with breast cancer under the age of 45 has impacted her life. . Created: 9/26/2016 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), Division of Cancer Prevention and Control (DCPC). Date Released: 9/26/2016.
Conley, Claire C; Bishop, Brenden T; Andersen, Barbara L
Emotional distress in cancer patients is an important outcome; however, emotional experience does not begin and end with emotion generation. Attempts to regulate emotions may lessen their potentially negative effects on physical and psychological well-being. Researchers have called for the study of emotion regulation (ER) in health psychology and psycho-oncology. Thus, this review has three aims. First, we discuss current understandings of emotion and ER across the cancer trajectory, including the principles of ER and methods for its assessment. Second, we present a model for examining the mediating effects of ER on psychosocial outcomes. Third, we "round out" the discussion with an example: new data on the role of ER in recurrent breast cancer. Taken together, these aims illustrate the impact of affective regulatory processes on cancer patients' long-term outcomes. As survival rates increase, long-term follow-up studies are needed to characterize the dynamic, reciprocal effects of emotion and ER for cancer survivors. Further research on ER may help women with breast cancer better manage the challenges associated with diagnosis and treatment.
Steineck, Gunnar; Skokic, Viktor; Bull, Cecilia; Alevronta, Eleftheria; Dunberger, Gail; Bergmark, Karin; Wilderäng, Ulrica; Oh, Jung Hun; Deasy, Joseph O.; Jörnsten, Rebecka
Background During radiotherapy unwanted radiation to normal tissue surrounding the tumor triggers survivorship diseases; we lack a nosology for radiation-induced survivorship diseases that decrease bowel health and we do not know which symptoms are related to which diseases. Methods Gynecological-cancer survivors were followed-up two to 15 years after having undergone radiotherapy; they reported in a postal questionnaire the frequency of 28 different symptoms related to bowel health. Population-based controls gave the same information. With a modified factor analysis, we determined the optimal number of factors, factor loadings for each symptom, factor-specific factor-loading cutoffs and factor scores. Results Altogether data from 623 survivors and 344 population-based controls were analyzed. Six factors best explain the correlation structure of the symptoms; for five of these a statistically significant difference (P< 0.001, Mann-Whitney U test) was found between survivors and controls concerning factor score quantiles. Taken together these five factors explain 42 percent of the variance of the symptoms. We interpreted these five factors as radiation-induced syndromes that may reflect distinct survivorship diseases. We obtained the following frequencies, defined as survivors having a factor loading above the 95 percent percentile of the controls, urgency syndrome (190 of 623, 30 percent), leakage syndrome (164 of 623, 26 percent), excessive gas discharge (93 of 623, 15 percent), excessive mucus discharge (102 of 623, 16 percent) and blood discharge (63 of 623, 10 percent). Conclusion Late effects of radiotherapy include five syndromes affecting bowel health; studying them and identifying the underlying survivorship diseases, instead of the approximately 30 long-term symptoms they produce, will simplify the search for prevention, alleviation and elimination. PMID:28158314
Lee, Ji Eun; Shin, Dong Wook; Lee, Hyejin; Son, Ki Young; Kim, Warrick Junsuk; Suh, Yun-Suhk; Kong, Seong-Ho; Lee, Hyuk Joon; Cho, Belong; Yang, Han-Kwang
Given the rapid growth of the population of cancer survivors, increased attention has been paid to their health problems. Although gastric cancer is one of the most common cancers, empirical evidence of survivorship care is limited. The objectives of this study were to describe the health care status of gastric cancer survivors and to report the experience of using the shared-care model during a one-year experience at the cancer survivorship clinic in Seoul National University Hospital. This is a descriptive, single-center study of 250 long-term gastric cancer survivors who were referred to the survivorship clinic. The status of their health behaviors, comorbid conditions, secondary cancer screenings, and survivorship care status were investigated through questionnaires and examining the medical records. Among the survivors, 7.2% were current smokers, 8.8% were at-risk drinkers, and 32.4% were physically inactive. Among the patients who did not know their bone density status, the majority were in the osteopenic (37.1%) or osteoporotic range (24.1%). Screening among the eligible population within the recommended time intervals were 76.3% for colorectal cancer, but only 13.6% for lung cancer. All of the survivors were provided with counseling and medical management at the survivorship clinic, as appropriate. In conclusion, Long-term gastric cancer survivors have various unmet needs. Shared-care through survivorship clinics can be an effective solution for providing comprehensive care to cancer survivors.
Full Text Available Management of breast cancer includes systematic therapies including chemotherapy and endocrine therapy can lead to a variety of symptoms that can impair the quality of life of many breast cancer survivors. Atrophic vaginitis, caused by decreased levels of circulating estrogen to urinary and vaginal receptors, is commonly experienced by this group. Chemotherapy induced ovarian failure and endocrine therapies including aromatase inhibitors and selective estrogen receptor modulators can trigger the onset of atrophic vaginitis or exacerbate existing symptoms. Symptoms of atrophic vaginitis include vaginal dryness, dyspareunia, and irritation of genital skin, pruritus, burning, vaginal discharge, and soreness. The diagnosis of atrophic vaginitis is confirmed through patient-reported symptoms and gynecological examination of external structures, introitus, and vaginal mucosa. Lifestyle modifications can be helpful but are usually insufficient to significantly improve symptoms. Non-hormonal vaginal therapies may provide additional relief by increasing vaginal moisture and fluid. Systemic estrogen therapy is contraindicated in breast cancer survivors. Continued investigations of various treatments for atrophic vaginitis are necessary. Local estrogen-based therapies, DHEA, testosterone, and pH-balanced gels continue to be evaluated in ongoing studies. Definitive results are needed pertaining to the safety of topical estrogens in breast cancer survivors.
More than 400 leading experts in cancer survivorship convened today for a conference, Cancer Survivorship Research: Translating Science to Care, to focus on such current concerns as how obesity might not have the same effects on all cancer survivors, and
Plotnikoff, Gregory A
Interventional nutrition is an emerging field in medicine that utilizes advanced laboratory technologies to identify a patient's clinically relevant biochemical uniqueness in order to treat the metabolic contributors to multifactorial symptoms such as fatigue, insomnia, and pain. This article presents a complex case in which a breast cancer patient's severe symptoms fit no clear disease pattern and prevented her from undergoing chemotherapy and radiation treatment. Specialized testing for metabolic, gastrointestinal, and immunologic function uncovered important nutritional deficiencies that could not be identified through isolated tests or addressed by supplementation with a daily multivitamin. Nutritional intervention based on specific measurements, rather than a one-size-fits-all approach to supplementation, resolved this patient's debilitating symptoms and restored her capacity to benefit from chemotherapy and radiation.
Harden, Janet; Sanda, Martin G.; Wei, John Thomas; Yarandi, Hossein N.; Hembroff, Larry; Hardy, Jill; Northouse, Laurel
Purpose/Objectives: To determine the long-term effects of prostate cancer treatment on spouse quality of life (QOL) at 36 months following treatment. Design: Descriptive-exploratory; community-based study. Setting: Telephone interviews. Sample: 95 female spouses of men treated for early-stage prostate cancer. Methods: A computer-assisted telephone interview was used to evaluate QOL among spouses of prostate cancer survivors at 36 months after initial prostate cancer treatment. Main Research Variables: Quality of life, dyadic adjustment, sexual satisfaction, appraisal of caregiving, and demographic information. Findings: Spouses who had more negative appraisal of caregiving had lower sexual satisfaction, poorer cancer-specific QOL, and poorer mental QOL. Spouses who perceived bother related to the patient’s sexual or hormone function reported more threatening appraisals of caregiving, less sexual satisfaction, and poorer QOL. Conclusions: Spouses continued to experience negative appraisal of caregiving, which affected QOL 36 months after their husbands’ treatment for prostate cancer. Additional studies related to factors that influence spouse QOL during survivorship will help guide clinical practice. Implications for Nursing: Healthcare providers must help spouses find strategies that promote positive coping and lessen negative appraisal. Giving caregivers information early in the treatment process will help them understand what to expect over time. Supporting caregivers and helping them manage stress will enhance QOL during survivorship. Knowledge Translation: Spouses who experienced more bother related to urinary, sexual, and hormonal function experience more stress and worse QOL at 36 months post-treatment. Spouse appraisal can have a significant effect on QOL. Offering counseling to couples following treatment for prostate cancer may improve QOL by helping couples manage relationship intimacy. PMID:24161635
Jerofke, Teresa A
The liberal usage of the concept of empowerment has led to the development of a broad and ambiguous term. In health care, empowerment is a core principle of patient-centered care that promotes patient engagement in health management. This is an analysis of the concept of empowerment within the context of cancer survivorship using both Rodgers' evolutionary concept analysis and Caron and Bower's dimensional analysis. The dimensional analysis followed the evolutionary concept analysis as the perspectives of patients and nurse providers emerged in the analysis. Data sources included a sample of 249 papers from multiple disciplines covering the period 2000-2013. Empowerment is defined as power-with that is actualized through a beneficial relationship of mutual trust and respect for autonomy that develops within a dynamic and patient-centered process. The attributes, along with the antecedents and consequences, provide a foundation for future theory development of empowerment in the context of cancer survivorship. This analysis demonstrated that although nurses and survivors may have a similar definition of the concept of empowerment, the uses and assumptions of that definition may differ. Future studies should be conducted measuring the effectiveness of an intervention that uses the components of the process of empowerment from survivors' perspectives.
Neil K. Aaronson
Full Text Available The population of cancer survivors has grown steadily over the past several decades. Surviving cancer, however, is not synonymous with a life free of problems related to the disease and its treatment. In this paper we provide a brief overview of selected physical and psychosocial health problems prevalent among cancer survivors, namely pain, fatigue, psychological distress and work participation. We also address issues surrounding self-management and e-Health interventions for cancer survivors, and programmes to encourage survivors to adopt healthier lifestyles. Finally, we discuss approaches to assessing health-related quality of life in cancer survivors, and the use of cancer registries in conducting psychosocial survivorship research. We highlight research and practice priorities in each of these areas. While the priorities vary per topic, common themes that emerged included: (1 Symptoms should not be viewed in isolation, but rather as part of a cluster of interrelated symptoms. This has implications for both understanding the aetiology of symptoms and for their treatment; (2 Psychosocial interventions need to be evidence-based, and where possible should be tailored to the needs of the individual cancer survivor. Relatively low cost interventions with self-management and e-Health elements may be appropriate for the majority of survivors, with resource intensive interventions being reserved for those most in need; (3 More effort should be devoted to disseminating and implementing interventions in practice, and to evaluating their cost-effectiveness; and (4 Greater attention should be paid to the needs of vulnerable and high-risk populations of survivors, including the socioeconomically disadvantaged and the elderly.
Mark Robert Albertella
Full Text Available The applications of functional genomics, proteomics and informatics to cancer research have yielded a tremendous amount of information, which is growing all the time. Much of this information is available publicly on the Internet and ranges from general information about different cancers from a patient or clinical viewpoint, through to databases suitable for cancer researchers of all backgrounds, to very specific sites dedicated to individual genes or molecules. A simple search for Ã¢Â€Â˜cancerÃ¢Â€Â™ from a typical Web browser search engine yields more than half a million hits; an even more specific search for Ã¢Â€Â˜leukaemiaÃ¢Â€Â™ (>40 000 hits or Ã¢Â€Â˜p53Ã¢Â€Â™ (>5700 hits yields far too many hits to allow one to identify particular sites of interest. This review aims to provide a brief guide to some of the resources and databases that can be used as springboards to home in rapidly on information relevant to many fields of cancer research. As such, this article will not focus on a single website but hopes to illustrate some of the ways that postgenomic biology is revolutionizing cancer research. It will cover genomics and proteomics approaches that have been applied to studying global expression patterns in cancers, in addition to providing links ranging from general information about cancer to specific cancer gene mutation databases.
For some survivors, the consequences of cancer are minimal;these patients can return to a normal life after the completion of treatment. In fact, a majority of cancer survivors report being in good general health and experience good to excellent quality of life. A recent review suggests that at least 50%of survivors suf er from some late ef ects of cancer treat-ment. The most common problems in cancer survivors are depression, pain, and fatigue. The guidelines suggest the fol owing standards for survivorship care:(1) prevention of new and recurrent cancers and other late ef ects;(2) surveil ance for cancer spread, recurrence, or second cancers;(3) assessment of late psychosocial and medical ef ects;(4) intervention for conse-quences of cancer and treatment (eg, medical problems, symptoms, psychologic distress, financial and social concerns);and (5) coordination of care between primary care providers and specialists to ensure that al of the survivor’s health needs are met. The NCCN Survivorship Panel hopes that these guidelines can help both oncologic and primary health care profession-als lessen the burden left on survivors by their cancer experience so they can transition back to a rewarding life.
Epstein, Joel B; Thariat, Juliette; Bensadoun, Rene-Jean; Barasch, Andrei; Murphy, Barbara A; Kolnick, Leanne; Popplewell, Leslie; Maghami, Ellie
Answer questions and earn CME/CNE Oral complications resulting from cancer and cancer therapies cause acute and late toxicities that may be underreported, underrecognized, and undertreated. Recent advances in cancer treatment have led to changes in the incidence, nature, and severity of oral complications. As the number of survivors increases, it is becoming increasingly recognized that the aggressive management of oral toxicities is needed to ensure optimal long-term oral health and general well-being. Advances in care have had an impact on previously recognized oral complications and are leading to newly recognized adverse effects. Here, the authors briefly review advances in cancer therapy, including recent advances in surgery, oral care, radiation therapy, hematopoietic cell transplantation, and medical oncology; describe how these advances affect oral health; and discuss the frequent and/or severe oral health complications associated with cancer and cancer treatment and their effect upon long-term health. Although some of the acute oral toxicities of cancer therapies may be reduced, they remain essentially unavoidable. The significant impact of long-term complications requires increased awareness and recognition to promote prevention and appropriate intervention. It is therefore important for the primary oncologist to be aware of these complications so that appropriate measures can be implemented in a timely manner. Prevention and management is best provided via multidisciplinary health care teams, which must be integrated and communicate effectively in order to provide the best patient care in a coordinated manner at the appropriate time.
U.S. Department of Health & Human Services — The State Cancer Profiles (SCP) web site provides statistics to help guide and prioritize cancer control activities at the state and local levels. SCP is a...
Nekhlyudov, Larissa; Lacchetti, Christina; Davis, Nancy B; Garvey, Thomas Q; Goldstein, David P; Nunnink, J Chris; Ninfea, Jose I Ruades; Salner, Andrew L; Salz, Talya; Siu, Lillian L
Purpose This guideline provides recommendations on the management of adults after head and neck cancer (HNC) treatment, focusing on surveillance and screening for recurrence or second primary cancers, assessment and management of long-term and late effects, health promotion, care coordination, and practice implications. Methods ASCO has a policy and set of procedures for endorsing clinical practice guidelines that have been developed by other professional organizations. The American Cancer Society (ACS) HNC Survivorship Care Guideline was reviewed for developmental rigor by methodologists. An ASCO Expert Panel reviewed the content and recommendations, offering modifications and/or qualifying statements when deemed necessary. Results The ASCO Expert Panel determined that the ACS HNC Survivorship Care Guideline, published in 2016, is clear, thorough, clinically practical, and helpful, despite the limited availability of high-quality evidence to support many of the recommendations. ASCO endorsed the ACS HNC Survivorship Care Guideline, adding qualifying statements aimed at promoting team-based, multispecialty, multidisciplinary, collaborative head and neck survivorship care. Recommendations The ASCO Expert Panel emphasized that caring for HNC survivors requires a team-based approach that includes primary care clinicians, oncology specialists, otolaryngologists, dentists, and other allied professionals. The HNC treatment team should educate the primary care clinicians and patients about the type(s) of treatment received, the likelihood of potential recurrence, and the potential late and long-term complications. Primary care clinicians should recognize symptoms of recurrence and coordinate a prompt evaluation. They should also be prepared to manage late effects either directly or by referral to appropriate specialists. Health promotion is critical, particularly regarding tobacco cessation and dental care. Additional information is available at www.asco.org/HNC-Survivorship
... cancer survivors were diagnosed with common cancers: 23% - breast cancer 21% - prostate cancer 9% - colorectal cancer 8% - cervical, uterine, or ovarian cancers 8% - melanoma The increased survival rates may be due to 4 major improvements: ...
Cancer Survivor; Stage IA Ovarian Epithelial Cancer; Stage IB Ovarian Epithelial Cancer; Stage IC Ovarian Epithelial Cancer; Stage IIA Ovarian Epithelial Cancer; Stage IIB Ovarian Epithelial Cancer; Stage IIC Ovarian Epithelial Cancer; Stage IIIA Ovarian Epithelial Cancer; Stage IIIB Ovarian Epithelial Cancer; Stage IIIC Ovarian Epithelial Cancer
Courneya, Kerry S.; Rogers, Laura Q.; Campbell, Kristin L.; Vallance, Jeff K.; Friedenreich, Christine M.
In the United States, there are more than 14 million cancer survivors. Many of these survivors have been treated with multimodal therapy including surgery, radiation therapy, chemotherapy, and targeted therapies. These therapies improve survival; however, they also cause acute and chronic side effects that can undermine health and quality of life.…
Cancer Survivor; Early-Stage Breast Carcinoma; Stage 0 Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage IIA Breast Cancer; Stage IIB Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer
Paper-Based Survivorship Care Plans May be Less Helpful for Cancer Patients Who Search for Disease-Related Information on the Internet: Results of the Registrationsystem Oncological Gynecology (ROGY) Care Randomized Trial
Nicolaije, K.A.; Ezendam, N.P.; Pijnenborg, J.M.A.; Boll, D.; Vos, M.C.; Kruitwagen, R.F.; Poll-Franse, L.V. van de
BACKGROUND: The Institute of Medicine recommends Survivorship Care Plans (SCPs) for all cancer survivors. However, it is unclear whether certain patient groups may or may not benefit from SCPs. OBJECTIVE: The aim was to assess whether the effects of an automatically generated paper SCP on patients'
Salz, Talya; Baxi, Shrujal
After completing treatment for cancer, the coordination of oncology and primary care presents a challenge for cancer survivors. Many survivors need continued oncology follow-up, and all survivors require primary care. Coordinating the shared care of a cancer survivor, or facilitating an informed handoff from oncology to primary care, is essential for cancer survivors. Survivorship care plans are personalized documents that summarize cancer treatment and outline a plan of recommended ongoing care, with the goal of facilitating the coordination of post-treatment care. Despite their face validity, five trials have failed to demonstrate the effectiveness of survivorship care plans. We posit that these existing trials have critical shortcomings and do not adequately address whether survivorship care plans improve care coordination. Moving forward, we propose four criteria for future trials of survivorship care plans: focusing on high-needs survivor populations, tailoring the survivorship care plan to the care setting, facilitating implementation of the survivorship care plan in clinical practice, and selecting appropriate trial outcomes to assess care coordination. When trials meet these criteria, we can finally assess whether survivorship care plans help cancer survivors receive optimal oncology and primary care.
Beyer, J; Albers, P; Altena, R; Aparicio, J; Bokemeyer, C; Busch, J; Cathomas, R; Cavallin-Stahl, E; Clarke, N W; Claßen, J; Cohn-Cedermark, G; Dahl, A A; Daugaard, G; De Giorgi, U; De Santis, M; De Wit, M; De Wit, R; Dieckmann, K P; Fenner, M; Fizazi, K; Flechon, A; Fossa, S D; Germá Lluch, J R; Gietema, J A; Gillessen, S; Giwercman, A; Hartmann, J T; Heidenreich, A; Hentrich, M; Honecker, F; Horwich, A; Huddart, R A; Kliesch, S; Kollmannsberger, C; Krege, S; Laguna, M P; Looijenga, L H J; Lorch, A; Lotz, J P; Mayer, F; Necchi, A; Nicolai, N; Nuver, J; Oechsle, K; Oldenburg, J; Oosterhuis, J W; Powles, T; Rajpert-De Meyts, E; Rick, O; Rosti, G; Salvioni, R; Schrader, M; Schweyer, S; Sedlmayer, F; Sohaib, A; Souchon, R; Tandstad, T; Winter, C; Wittekind, C
In November 2011, the Third European Consensus Conference on Diagnosis and Treatment of Germ-Cell Cancer (GCC) was held in Berlin, Germany. This third conference followed similar meetings in 2003 (Essen, Germany) and 2006 (Amsterdam, The Netherlands) [Schmoll H-J, Souchon R, Krege S et al. European consensus on diagnosis and treatment of germ-cell cancer: a report of the European Germ-Cell Cancer Consensus Group (EGCCCG). Ann Oncol 2004; 15: 1377-1399; Krege S, Beyer J, Souchon R et al. European consensus conference on diagnosis and treatment of germ-cell cancer: a report of the second meeting of the European Germ-Cell Cancer Consensus group (EGCCCG): part I. Eur Urol 2008; 53: 478-496; Krege S, Beyer J, Souchon R et al. European consensus conference on diagnosis and treatment of germ-cell cancer: a report of the second meeting of the European Germ-Cell Cancer Consensus group (EGCCCG): part II. Eur Urol 2008; 53: 497-513]. A panel of 56 of 60 invited GCC experts from all across Europe discussed all aspects on diagnosis and treatment of GCC, with a particular focus on acute and late toxic effects as well as on survivorship issues. The panel consisted of oncologists, urologic surgeons, radiooncologists, pathologists and basic scientists, who are all actively involved in care of GCC patients. Panelists were chosen based on the publication activity in recent years. Before the meeting, panelists were asked to review the literature published since 2006 in 20 major areas concerning all aspects of diagnosis, treatment and follow-up of GCC patients, and to prepare an updated version of the previous recommendations to be discussed at the conference. In addition, ∼50 E-vote questions were drafted and presented at the conference to address the most controversial areas for a poll of expert opinions. Here, we present the main recommendations and controversies of this meeting. The votes of the panelists are added as online supplements.
Beyer, J.; Albers, P.; Altena, R.; Aparicio, J.; Bokemeyer, C.; Busch, J.; Cathomas, R.; Cavallin-Stahl, E.; Clarke, N. W.; Claßen, J.; Cohn-Cedermark, G.; Dahl, A. A.; Daugaard, G.; De Giorgi, U.; De Santis, M.; De Wit, M.; De Wit, R.; Dieckmann, K. P.; Fenner, M.; Fizazi, K.; Flechon, A.; Fossa, S. D.; Germá Lluch, J. R.; Gietema, J. A.; Gillessen, S.; Giwercman, A.; Hartmann, J. T.; Heidenreich, A.; Hentrich, M.; Honecker, F.; Horwich, A.; Huddart, R. A.; Kliesch, S.; Kollmannsberger, C.; Krege, S.; Laguna, M. P.; Looijenga, L. H. J.; Lorch, A.; Lotz, J. P.; Mayer, F.; Necchi, A.; Nicolai, N.; Nuver, J.; Oechsle, K.; Oldenburg, J.; Oosterhuis, J. W.; Powles, T.; Rajpert-De Meyts, E.; Rick, O.; Rosti, G.; Salvioni, R.; Schrader, M.; Schweyer, S.; Sedlmayer, F.; Sohaib, A.; Souchon, R.; Tandstad, T.; Winter, C.; Wittekind, C.
In November 2011, the Third European Consensus Conference on Diagnosis and Treatment of Germ-Cell Cancer (GCC) was held in Berlin, Germany. This third conference followed similar meetings in 2003 (Essen, Germany) and 2006 (Amsterdam, The Netherlands) [Schmoll H-J, Souchon R, Krege S et al. European consensus on diagnosis and treatment of germ-cell cancer: a report of the European Germ-Cell Cancer Consensus Group (EGCCCG). Ann Oncol 2004; 15: 1377–1399; Krege S, Beyer J, Souchon R et al. European consensus conference on diagnosis and treatment of germ-cell cancer: a report of the second meeting of the European Germ-Cell Cancer Consensus group (EGCCCG): part I. Eur Urol 2008; 53: 478–496; Krege S, Beyer J, Souchon R et al. European consensus conference on diagnosis and treatment of germ-cell cancer: a report of the second meeting of the European Germ-Cell Cancer Consensus group (EGCCCG): part II. Eur Urol 2008; 53: 497–513]. A panel of 56 of 60 invited GCC experts from all across Europe discussed all aspects on diagnosis and treatment of GCC, with a particular focus on acute and late toxic effects as well as on survivorship issues. The panel consisted of oncologists, urologic surgeons, radiooncologists, pathologists and basic scientists, who are all actively involved in care of GCC patients. Panelists were chosen based on the publication activity in recent years. Before the meeting, panelists were asked to review the literature published since 2006 in 20 major areas concerning all aspects of diagnosis, treatment and follow-up of GCC patients, and to prepare an updated version of the previous recommendations to be discussed at the conference. In addition, ∼50 E-vote questions were drafted and presented at the conference to address the most controversial areas for a poll of expert opinions. Here, we present the main recommendations and controversies of this meeting. The votes of the panelists are added as online supplements. PMID:23152360
Burke, Shaunna M.; Sabiston, Catherine M.
The aim of this study was to use an ethnographic case study approach to explore breast cancer survivors' experiences scaling Mt. Kilimanjaro from a posttraumatic growth perspective. Three breast cancer survivors who participated in interviews and observations during a nine-day climb on the mountain were included in this study. Findings are…
Samuel, C A; Faithfull, S
This study reviewed the confidence and perceived skills of complementary and alternative medicine (CAM) practitioners in providing care and symptom management for clients post cancer. An e-survey was mailed to approximately 21, 000 CAM practitioners, targeted at those working with clients who were experiencing consequences of cancer and its treatments. Questions were asked about the main symptoms and concerns of clients, the confidence and current skill levels of practitioners and additional training requirements. Six hundred and twelve practitioners responded to the survey, 507 of whom were working with individuals experiencing the consequences of cancer and its treatments. Forty-five per cent (n = 134) had undertaken training in cancer prior to working with cancer patients, 61% (n = 182) had undertaken courses or study days relative to cancer care in the past two years. The most often treated symptoms or concerns of patients were those of a psychosocial nature, pain management and lymphoedema. CAM practitioners with limited knowledge and training are providing support to cancer survivors, particularly in services where the National Health Service has limited provision. CAM practitioners may fulfil a future role in providing long-term support for cancer survivors; however, in order to properly safeguard patients they are in need of further training and development.
Adenocarcinoma of the Lung; Mucinous Adenocarcinoma of the Colon; Mucinous Adenocarcinoma of the Rectum; Signet Ring Adenocarcinoma of the Colon; Signet Ring Adenocarcinoma of the Rectum; Squamous Cell Lung Cancer; Stage I Colon Cancer; Stage I Rectal Cancer; Stage IA Non-small Cell Lung Cancer; Stage IB Non-small Cell Lung Cancer; Stage IIA Colon Cancer; Stage IIA Non-small Cell Lung Cancer; Stage IIA Rectal Cancer; Stage IIB Colon Cancer; Stage IIB Non-small Cell Lung Cancer; Stage IIB Rectal Cancer; Stage IIC Colon Cancer; Stage IIC Rectal Cancer; Stage IIIA Colon Cancer; Stage IIIA Non-small Cell Lung Cancer; Stage IIIA Rectal Cancer; Stage IIIB Colon Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IIIB Rectal Cancer; Stage IIIC Colon Cancer; Stage IIIC Rectal Cancer
... Positive Family Hope Resources for Care Providers Toolbox Facilitator’s Manual Hoping for Health Care Professionals Health Insurance ... over the last year, and we support the role [...] Read More » Highlights from the 2016 CPAT Symposium ...
Study protocol for a randomised controlled trial of brief, habit-based, lifestyle advice for cancer survivors: exploring behavioural outcomes for the Advancing Survivorship Cancer Outcomes Trial (ASCOT)
Beeken, Rebecca J; Croker, Helen; Heinrich, Maggie; Smith, Lee; Williams, Kate; Hackshaw, Allan; Hines, John; Machesney, Michael; Krishnaswamy, Madhavan; Cavanagh, Sharon; Roylance, Rebecca; Hill, Alison; Pritchard-Jones, Kathy; Wardle, Jane; Fisher, Abigail
Introduction Positive health behaviours such as regular physical activity and a healthy diet have significant effects on cancer outcomes. There is a need for simple but effective behaviour change interventions with the potential to be implemented within the cancer care pathway. Habit-based advice encourages repetition of a behaviour in a consistent context so that the behaviour becomes increasingly automatic in response to a specific contextual cue. This approach therefore encourages long-term behaviour change and can be delivered through printed materials. ‘Healthy Habits for Life’ is a brief intervention based on habit theory, and incorporating printed materials plus a personally tailored discussion, that has been designed specifically for patients with a diagnosis of cancer. The aim of this trial was to test the effect of ‘Healthy Habits for Life’ on a composite health behaviour risk index (CHBRI) over 3 months in patients with a diagnosis of breast, colorectal or prostate cancer. Method and analysis A 2-arm, individually randomised controlled trial in patients with breast, colorectal and prostate cancer. Patients will be recruited over 18 months from 7 National Health Service Trusts in London and Essex. Following baseline assessments and allocation to intervention or usual care, patients are followed up at 3 and 6 months. The primary outcome will be change in CHBRI at 3 months. Maintenance of any changes over 6 months, and changes in individual health behaviours (including dietary intake, physical activity, alcohol consumption and smoking status) will also be explored. Ethics and dissemination Ethical approval was obtained through the National Research Ethics Service Committee South Central—Oxford B via the Integrated Research Application System (reference number 14/SC/1369). Results of this study will be disseminated through peer-reviewed publications and scientific presentations. Trial registration number 17421871. PMID:27881518
Yang, Yadong; Dong, Xunong; Xie, Bingbing; Ding, Nan; Chen, Juan; Li, Yongjun; Zhang, Qian; Qu, Hongzhu; Fang, Xiangdong
Publicly-accessible resources have promoted the advance of scientific discovery. The era of genomics and big data has brought the need for collaboration and data sharing in order to make effective use of this new knowledge. Here, we describe the web resources for cancer genomics research and rate them on the basis of the diversity of cancer types, sample size, omics data comprehensiveness, and user experience. The resources reviewed include data repository and analysis tools; and we hope such introduction will promote the awareness and facilitate the usage of these resources in the cancer research community.
Yadong Yang; Xunong Dong; Bingbing Xie; Nan Ding; Juan Chen; Yongjun Li; Qian Zhang; Hongzhu Qu; Xiangdong Fang
Publicly-accessible resources have promoted the advance of scientific discovery. The era of genomics and big data has brought the need for collaboration and data sharing in order to make effective use of this new knowledge. Here, we describe the web resources for cancer genomics research and rate them on the basis of the diversity of cancer types, sample size, omics data com-prehensiveness, and user experience. The resources reviewed include data repository and analysis tools;and we hope such introduction will promote the awareness and facilitate the usage of these resources in the cancer research community.
Holford, Matt; Cheung, Kei; Krauthammer, Michael
Our work concerns the elucidation of the cancer (epi)genome, transcriptome and proteome to better understand the complex interplay between a cancer cell's molecular state and its response to anti-cancer therapy. To study the problem, we have previously focused on data warehousing technologies and statistical data integration. In this paper, we present recent work on extending our analytical capabilities using Semantic Web technology. A key new component presented here is a SPARQL endpoint to our existing data warehouse. This endpoint allows the merging of observed quantitative data with existing data from semantic knowledge sources such as Gene Ontology (GO). We show how such variegated quantitative and functional data can be integrated and accessed in a universal manner using Semantic Web tools. We also demonstrate how Description Logic (DL) reasoning can be used to infer previously unstated conclusions from existing knowledge bases. As proof of concept, we illustrate the ability of our setup to answer compl...
Kvale, Elizabeth; Urba, Susan G
The NCCN Clinical Practice Guidelines in Oncology for Survivorship include a new section on cancer-associated cognitive impairment and an expanded section on adult cancer pain that more completely addresses chemotherapy-induced peripheral neuropathy. These additions to the guidelines are the result of increasing awareness that long-term cancer survivors struggle with many late effects. Both the assessment and the management of cognitive impairment still lack a strong evidence-based foundation. The management of peripheral neuropathy, including the use of anti-depressants and opioids, often in combination, is backed by data primarily derived from clinical trials performed for various types of peripheral neuropathy.
... HUMAN SERVICES National Institutes of Health Proposed Collection; Comment Request; NCI Cancer Genetics Services Directory Web-Based Application Form and Update Mailer Summary: In compliance with the requirement... included in the NCI Cancer Genetics Services Directory on NCI's Cancer.gov Web site. The...
Beyer, J.; Albers, P.; Altena, R.; Aparicio, J.; Bokemeyer, C.; Busch, J.; Cathomas, R.; Cavallin-Stahl, E.; Clarke, N. W.; Classen, J.; Cohn-Cedermark, G.; Dahl, A. A.; Daugaard, G.; De Giorgi, U.; De Santis, M.; De Wit, M.; De Wit, R.; Dieckmann, K. P.; Fenner, M.; Fizazi, K.; Flechon, A.; Fossa, S. D.; Germa Lluch, J. R.; Gietema, J. A.; Gillessen, S.; Giwercman, A.; Hartmann, J.T.; Heidenreich, A.; Hentrich, M.; Honecker, F.; Horwich, A.; Huddart, R. A.; Kliesch, S.; Kollmannsberger, C.; Krege, S.; Laguna, M. P.; Looijenga, L. H. J.; Lorch, A.; Lotz, J. P.; Mayer, F.; Necchi, A.; Nicolai, N.; Nuver, J.; Oechsle, K.; Oldenburg, J.; Oosterhuis, J.W.; Powles, T.; Rajpert-De Meyts, E.; Rick, O.; Rosti, G.; Salvioni, R.; Schrader, M.; Schweyer, S.; Sedlmayer, F.; Sohaib, A.; Souchon, R.; Tandstad, T.; Wittekind, C.; Winter, E.
In November 2011, the Third European Consensus Conference on Diagnosis and Treatment of Germ-Cell Cancer (GCC) was held in Berlin, Germany. This third conference followed similar meetings in 2003 (Essen, Germany) and 2006 (Amsterdam, The Netherlands) [Schmoll H-J, Souchon R, Krege S et al. European
J. Beyer (Jörg); P. Albers (Peter); R. Altena (Renske); J. Aparicio (Jorge); C. Bokemeyer; J. Busch (Jamie); R. Cathomas (Richard); E. Cavallin-Stahl (Eva); N.W. Clarke (Noel); J. Claßen (Johannes); G. Cohn-Cedermark (Gabriella); A.A. Dahl; G. Daugaard (Gedske); U. de Giorgi (Ugo); M. de Santis (Maria); M. De Wit (Meike); R. de Wit (Ronald); K.P. Dieckmann; M. Fenner (Martin); K. Fizazi (Karim); A. Flechon (Aude); S.D. Fossa (Sophie); J.R. Germá Lluch (José Ramón); J.A. Gietema (Jourik); S. Gillessen (Silke); A. Giwercman (Aleksander); J.T. Hartmann; A. Heidenreich (Axel); M. Hentrich (Marcus); F.U. Honecker (Friedemann); A. Horwich; R.A. Huddart (Robbert); S. Kliesch (Sabine); C. Kollmannsberger (Christian); S. Krege (Susanne); M.P. Laguna (Maria Pilar); L.H.J. Looijenga (Leendert); A. Lorch (Anja); J.P. Lotz (Jean Pierre); F. Mayer; A. Necchi (Andrea); N. Nicolai (Nicola); J. Nuver (Janine); K. Oechsle (Karin); J. Oldenburg (Jan); J.W. Oosterhuis (Wolter); T. Powles (Tom); E. Rajpert-De Meyts (Ewa); O. Rick (Oliver); G. Rosti (Giovanni); R. Salvioni (Roberto); C. Winter (Christopher); C. Wittekind (Christian)
textabstractIn November 2011, the Third European Consensus Conference on Diagnosis and Treatment of Germ-Cell Cancer (GCC) was held in Berlin, Germany. This third conference followed similar meetings in 2003 (Essen, Germany) and 2006 (Amsterdam, The Netherlands) [Schmoll H-J, Souchon R, Krege S et a
Pam Bryant, una sobreviviente de cÃ¡ncer de mama, habla sobre su viaje personal y cÃ³mo impactÃ³ su vida el recibir un diagnÃ³stico de cÃ¡ncer de mama antes de los 45 aÃ±os. . Created: 10/18/2016 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), Division of Cancer Prevention and Control (DCPC). Date Released: 10/18/2016.
Hansen, Hans Oluf
mortality in terms of degenerative aging (senescence); and environ-mental influence on survivorship. As the model is fitted to empirical cohort mortality exhibit-ing extreme variation, biological aging is identified up to a multiplicative factor. Mortality of elected cohorts born in Sweden, Denmark......, and Iceland during the past 250 years and in Japan any ten years between 1950 and 1990 is approached appropriately by the model. Reduced natural selection may account for a substantial part of the empirical mortality change in the course of the demographic transition. Survivorship in the late nineteenth...
McAfee, P C; Weiland, D J; Carlow, J J
Between 1985 and 1989, the senior author performed 120 consecutive pedicle instrumentation cases--78 Steffee (VSP) procedures and 42 procedures using Cotrel-Dubousset instrumentation. Posterolateral or posterior fusions using autogenous iliac bone graft were performed across the instrumented vertebrae in all cases. Survivorship analysis was used to calculate a predicted cumulative rate of success for this series of patients over 10 years postoperative follow-up. The criteria of failure of pedicular instrumentation or "death" of an implant were defined as 1) screw bending, 2) screw breakage, 3) infection, 4) loosening of implants, 5) any rod or plate hardware problems, or 6) removal of hardware due to a neurologic complication. Out of 526 pedicle screws (175 Cotrel-Dubousset screws, 351 VSP screws) there were 22 problem screws (22/526 = 4.18%). Six screws had bent, none were infected, 16 screws had broken, and none were loose. The 22 problem screw events occurred in 12 patients. In seven patients, the instrumentation failure was an incidental radiographic finding, in that patients had a solid posterolateral fusion. The remaining five patients had screw breakage in association with a pseudarthrosis. Life table calculations predicted the survivorship of instrumentation without complications would be 80% at 10 years postoperative follow-up. Actuarial analysis predicted the survivorship of solid posterolateral fusion at 90% at 10 years follow-up. This survivorship rate is similar to those predicted at 10 years follow-up for other more widely used orthopedic surgical implants such as total hip arthroplasty components.
Huang, Tingting; Liu, Jialin; Li, Yong; Zhang, Rui
In order to support the theory and practice of the web-based cancer database development in China, we applied a systematic evaluation to assess the development condition of the web-based cancer databases at home and abroad. We performed computer-based retrieval of the Ovid-MEDLINE, Springerlink, EBSCOhost, Wiley Online Library and CNKI databases, the papers of which were published between Jan. 1995 and Dec. 2011, and retrieved the references of these papers by hand. We selected qualified papers according to the pre-established inclusion and exclusion criteria, and carried out information extraction and analysis of the papers. Eventually, searching the online database, we obtained 1244 papers, and checking the reference lists, we found other 19 articles. Thirty-one articles met the inclusion and exclusion criteria and we extracted the proofs and assessed them. Analyzing these evidences showed that the U.S.A. counted for 26% in the first place. Thirty-nine percent of these web-based cancer databases are comprehensive cancer databases. As for single cancer databases, breast cancer and prostatic cancer are on the top, both counting for 10% respectively. Thirty-two percent of the cancer database are associated with cancer gene information. For the technical applications, MySQL and PHP applied most widely, nearly 23% each.
Friedman, Daniela B; Koskan, Alexis; Rose, India D
Little is known about prostate cancer (PrCA) screening information on participatory, interactive, and consumer-generated websites collectively referred to as Web 2.0. A content analysis was conducted of PrCA resources on four highly trafficked Web 2.0 social bookmarking sites. A total of 127 webpages were analyzed. Most content was from news websites (48.9%) and blogs (37.8%). PrCA screening was mentioned on 95.3% of pages; only 30.7% discussed the prostate-specific antigen test. Less than half (43.8%) mentioned current screening guidelines. PrCA content is inconsistent on Web 2.0 sites. Future research should assess the readability and usability of Web 2.0 cancer resources.
Carlyle C. Brewster
Full Text Available Four bed bug strains (Cimex lectularius with different levels of pyrethroid resistance were evaluated to determine their ability to survive extended periods of starvation. First instar bed bugs of all strains were the most vulnerable to starvation (13.8–36.3 days mean survival time. Fifth instars and adults survived the longest during starvation (41.5–142.6 days. Significant differences in survivorship during starvation were observed between resistant and susceptible strains of bed bugs. Overall, all immature and adult stages of the resistant bed bug strains had significantly shorter survival times than those of the susceptible strains (P < 0.05.
Polanco, Andrea M; Miller, Dini M; Brewster, Carlyle C
Four bed bug strains (Cimex lectularius) with different levels of pyrethroid resistance were evaluated to determine their ability to survive extended periods of starvation. First instar bed bugs of all strains were the most vulnerable to starvation (13.8-36.3 days mean survival time). Fifth instars and adults survived the longest during starvation (41.5-142.6 days). Significant differences in survivorship during starvation were observed between resistant and susceptible strains of bed bugs. Overall, all immature and adult stages of the resistant bed bug strains had significantly shorter survival times than those of the susceptible strains (P < 0.05).
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Sas, Arthur A; Snieder, Harold; Korf, Jakob
We defend the hypothesis that life-spanning population survivorship curves, as described by Gompertz' law and composed from cross-sectional data (here mortality), reflect an intrinsic aging principle active in each subject of that population. In other words Gompertz' law reflects aging of a prototypical subject, provided minimal (or no) external causes of death (i.e. fatal infections, starvation, accidents). Our approach deviates from the traditional (exponential) Gompertz' hazard function. For instance, the here formulated Gompertz' law accurately describes old-age deceleration of both all-cause mortality and the incidence of some ageing-associated cancers, as illustrated for the Dutch population. We consider the possibility that the old-age expression and progression of cancer and other pathologies becomes suppressed, because of random (and exponential) accumulation of damage during life. Gompertz' law may trigger new concepts and models describing life-spanning physiological and pathological processes of aging. We discuss (and reject) various aging models (e.g. a predominant role of individual variations at birth; reliability theory) and point to the explanatory potential of network models and systemic regulatory models.
J. Giesbers; I.M. Verdonck-de Leeuw; F.J. van Zuuren; N. Kleverlaan; M.H.M van der Linden
Objective: To investigate the use and content of web-based peer support in children coping with parental cancer. Methods: In children aged above 12 years, 158 forum discussions on the Dutch website www.kankerspoken.nl in a time-period of 3 months were investigated. Age, gender, number of discussions
Morgagni, Paolo; Verlato, Giuseppe; Marrelli, Daniele; Roviello, Franco; de Manzoni, Giovanni
In an attempt to attract a wider diversity of professionals to the 10th International Gastric Cancer Association Congress (IGCC) held in June 2013, the Scientific Committee of the conference organized a number of pre-congress Web Round Tables to discuss cutting-edge topics relating to gastric cancer treatment. Twenty Web Round Tables, each coordinated by a different chairman, were proposed on the IGCC Website 1 year before the congress. Each chairman identified a number of studies related to the theme of his/her Round Table and invited corresponding authors to send an update of their conclusions in light of their subsequent experience, which would then form the basis of discussion of the Web Round Tables. The chairmen posted several questions regarding these updates on the web and opened a forum for a period of 1-2 months. The forum was free and specifically intended for congress participants. Fifty-one (9.9 %) of the 516 authors contacted took part in the initiative. Two hundred fifty participants from 21 countries joined the forum discussion and posted 671 comments. The Web Round Tables were viewed 15,810 times while the forum was open. Overall, the Web Round Tables aroused considerable interest, especially among young professionals working in the area of gastric cancer who had the opportunity to contact and interact with experts in what often turned out to be an interesting and lively exchange of views. All the discussions are now freely available for consultation on the IGCC website. The Web Round Table experience was presented, with great success, during the conference at special afternoon sessions.
Suzuki, Lalita K; Beale, Ivan L
The content of personal Web home pages created by adolescents with cancer is a new source of information about this population of potential benefit to oncology nurses and psychologists. Individual Internet elements found on 21 home pages created by youths with cancer (14-22 years old) were rated for cancer-related self-presentation, information dissemination, and interpersonal connection. Examples of adolescents' online narratives were also recorded. Adolescents with cancer used various Internet elements on their home pages for cancer-related self-presentation (eg, welcome messages, essays, personal history and diary pages, news articles, and poetry), information dissemination (e.g., through personal interest pages, multimedia presentations, lists, charts, and hyperlinks), and interpersonal connection (eg, guestbook entries). Results suggest that various elements found on personal home pages are being used by a limited number of young patients with cancer for self-expression, information access, and contact with peers.
Alexander, James; Kwon, Harry T; Strecher, Rachael; Bartholomew, Jill
Ethnic media can serve as an opportunity for cancer education and outreach to minority communities. The National Cancer Institute developed the Multicultural Media Outreach (MMO) program which utilizes an integrated approach of both traditional and social media to disseminate evidence-based cancer education information for minority communities. The MMO program is the contact point for multicultural media outlets seeking evidence-based cancer information, education materials, minority spokespersons, and news tailored to minority communities affected by cancer health disparities. MMO developed Lifelines®, a cancer education series that addresses cancer prevention, treatment, survivorship, clinical trials, and other cancer-related topics for African American, Hispanic, Asian American, American Indian, and Alaska Native audiences. Lifelines® content is disseminated through traditional media (radio, print, and television) as well as social media (web, Twitter, YouTube, and RSS feed). This article describes the MMO program and lessons learned to date.
Northouse, Laurel; Schafenacker, Ann; Barr, Kathryn L.C.; Katapodi, Maria; Yoon, Hyojin; Brittain, Kelly; Song, Lixin; Ronis, David L.; An, Larry
Background Most programs addressing psychosocial concerns of cancer survivors are in-person programs that are expensive to deliver, have limited availability, and seldom deal with caregivers’ concerns. Objective This study examined the feasibility of translating an efficacious nurse-delivered program (FOCUS Program) for patients and their caregivers to a tailored, dyadic web-based format. Specific aims were to: (i) test the preliminary effects of the web-based intervention on patient and caregiver outcomes, (ii) examine participants’ program satisfaction, and (iii) determine the feasibility of using a web-based delivery format. Intervention/Methods A Phase II feasibility study was conducted with cancer patients (lung, breast, colorectal, prostate) and their family caregivers (N=38 dyads). The web-based intervention provided information and support tailored to the unique characteristics of each patient, caregiver, and their dyadic relationship. Primary outcomes were emotional distress and quality of life (QOL). Secondary outcomes were benefits of illness/caregiving, communication, support, and self-efficacy. Analyses included descriptive statistics and repeated measures ANOVA. Results Dyads had a significant decrease in emotional distress, increase in QOL, and perceived more benefits of illness/caregiving. Caregivers also had significant improvement in self-efficacy. There were no changes in communication. Participants were satisfied with program usability, but recommended additional content. Conclusions It was possible to translate a clinician-delivered program to a web-based format that was easy to use and had positive effects on dyadic outcomes. Implications for Practice The web-based program is a promising way to provide psychosocial care to more patients and caregivers using fewer personnel. It needs further testing in a larger RCT. PMID:24945270
Foster, Claire; Calman, Lynn; Grimmett, Chloe; Breckons, M.; Cotterell, P.; Yardley, Lucy; Joseph, J.; Hughes, S.; Jones, R.; Leonidou, C.; Armes, Jo; Batehup, Lynn; Corner, Jessica; Fenlon, Deborah; Lennan, E
Objective: the aim of this study is to co-create an evidence-based and theoretically informed web-based intervention (RESTORE) designed to enhance self-efficacy to live with cancer-related fatigue (CRF) following primary cancer treatment. Methods: a nine-step process informed the development of the intervention: (1) review of empirical literature; (2) review of existing patient resources; (3) establish theoretical framework; (4) establish design team with expertise in web-based interventi...
Meagher, Susan; Scheurer, Michael; Folta, Sara; Finnan, Emily; Criss, Kerry; Economos, Christina; Dreyer, ZoAnn; Kelly, Michael
Background Due to advances in the field of oncology, survival rates for children with cancer have improved significantly. However, these childhood cancer survivors are at a higher risk for obesity and cardiovascular diseases and for developing these conditions at an earlier age. Objective In this paper, we describe the rationale, conceptual framework, development process, novel components, and delivery plan of a behavioral intervention program for preventing unhealthy weight gain in survivors of childhood acute lymphoblastic leukemia (ALL). Methods A Web-based program, the Healthy Eating and Active Living (HEAL) program, was designed by a multidisciplinary team of researchers who first identified behaviors that are appropriate targets for weight management in childhood ALL survivors and subsequently developed the intervention components, following core behavioral change strategies grounded in social cognitive and self-determination theories. Results The Web-based HEAL curriculum has 12 weekly self-guided sessions to increase parents’ awareness of the potential impact of cancer treatment on weight and lifestyle habits and the importance of weight management in survivors’ long-term health. It empowers parents with knowledge and skills on parenting, nutrition, and physical activity to help them facilitate healthy eating and active living soon after the child completes intensive cancer treatment. Based on social cognitive theory, the program is designed to increase behavioral skills (goal-setting, self-monitoring, and problem-solving) and self-efficacy and to provide positive reinforcement to sustain behavioral change. Conclusions Lifestyle interventions are a priority for preventing the early onset of obesity and cardiovascular risk factors in childhood cancer survivors. Intervention programs need to meet survivors’ targeted behavioral needs, address specific barriers, and capture a sensitive window for behavioral change. In addition, they should be convenient
Friedman, Daniela B; Hoffman-Goetz, Laurie
Adequate functional literacy skills positively influence individuals' ability to take control of their health. Print and Web-based cancer information is often written at difficult reading levels. This systematic review evaluates readability instruments (FRE, F-K, Fog, SMOG, Fry) used to assess print and Web-based cancer information and word recognition and comprehension tests (Cloze, REALM, TOFHLA, WRAT) that measure people's health literacy. Articles on readability and comprehension instruments explicitly used for cancer information were assembled by searching MEDLINE and Psyc INFO from 1993 to 2003. In all, 23 studies were included; 16 on readability, 6 on comprehension, and 1 on readability and comprehension. Of the readability investigations, 14 focused on print materials, and 2 assessed Internet information. Comprehension and word recognition measures were not applied to Web-based information. None of the formulas were designed to determine the effects of visuals or design factors that could influence readability and comprehension of cancer education information.
Gibson, Lynette M; Thomas, Sheila; Parker, Veronica; Mayo, Rachel; Wetsel, Margaret Ann
The purpose of this study was to describe breast cancer fear according to phase of survivorship, determine whether breast cancer fear levels differed among survivorship phases, and determine the relationship between fear and age in African-American breast cancer survivors. The study utilized secondary data analysis from the study, Inner Resources as Predictors of Psychological Well-Being in AABCS. A new subscale entitled, "Breast Cancer Fear" was adapted from the Psychological Well Being Subscale by Ferrell and Grant. There was no significant difference between fear and phase of survivorship. There was a significant positive relationship between age and fear.
Sas, Arthur A.; Snieder, Harold; Korf, Jakob
We defend the hypothesis that life-spanning population survivorship curves, as described by Gompertz' law and composed from cross-sectional data (here mortality), reflect an intrinsic aging principle active in each subject of that population. In other words Gompertz' law reflects aging of a prototyp
A specification of mortality or survivorship provides respective explicit details about mortality's or survivorship's relationships with one or more other variables (e.g., age, sex, etc.). Previous studies have discovered and analyzed diverse specifications of mortality or survivorship; these discoveries and analyses suggest that additional specifications of mortality or survivorship have yet to be discovered and analyzed. In consistency with previous research, multivariable limited powered polynomials regression analyses of mortality and survivorship of selected humans (Swedes, 1760–2008) and selected insects (caged medflies) show age-specific, historical-time-specific, environmental-context-specific, and sex-specific mortality and survivorship. These analyses also present discoveries of hitherto unknown lifespan-specific, contemporary-aggregate-size-specific, and lifespan-aggregate-size-specific mortality and survivorship. The results of this investigation and results of previous research help identify variables for inclusion in regression models of mortality or survivorship. Moreover, these results and results of previous research strengthen the suggestion that additional specifications of mortality or survivorship have yet to be discovered and analyzed, and they also suggest that specifications of mortality and survivorship indicate corresponding specifications of frailty and vitality. Furthermore, the present analyses reveal the usefulness of a multivariable limited powered polynomials regression model-building approach. This article shows that much has yet to be learned about specifications of mortality or survivorship of diverse kinds of individuals in diverse times and places. PMID:24454719
Shaikh, Waqas R; Geller, Alan; Alexander, Gwen; Asgari, Maryam M; Chanange, Gunther J; Dusza, Stephen; Eide, Melody J; Fletcher, Suzanne W; Goulart, Jacqueline M; Halpern, Allan C; Landow, Shoshana; Marghoob, Ashfaq A; Quigley, Elizabeth A; Weinstock, Martin A
Web-based learning in medical education is rapidly growing. However, there are few firsthand accounts on the rationale for and development of web-based learning programs. We present the experience of clinical educators who developed an interactive online skin cancer detection and management course in a time-efficient and cost-efficient manner without any prior skills in computer programming or technical construction of web-based learning programs. We review the current state of web-based learning including its general advantages and disadvantages as well as its specific utility in dermatology. We then detail our experience in developing an interactive online skin cancer curriculum for primary care clinicians. Finally, we describe the main challenges faced and lessons learned during the process. This report may serve medical educators who possess minimal computer programming and web design skills but want to employ the many strengths of web-based learning without the huge costs associated with hiring a professional development team.
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Villanueva, Ronald D; Yap, Helen T; Montaño, Marco Nemesio E
Intensive fish farming is an emerging coastal activity that can potentially enhance sedimentation and promote eutrophication in fringing coral reefs. Here, we investigate the effect of fish farm effluent on the juvenile survivorship of the reef-building coral Seriatopora caliendrum. One-month old juvenile corals (on terracotta tiles) were deployed in fish farm and reference (reef) sites in Bolinao, the Philippines at a depth of 2m. After forty days, no survivor was recovered in the fish farm, while survivorship was low (11%) in the reference site, with the survivors' growth rate at 3.3polypsmo(-1) or 1.3mm(2)mo(-1). The fish farm deployed tiles were covered with muddy sediment and were colonized by barnacles, whereas those in the reference site were overgrown by a short stand of filamentous macroalgae. Environmental monitoring revealed higher nutrient levels (ammonia and phosphate), sedimentation rate, and organic matter flux, as well as diminished water transparency and dissolved oxygen levels in the fish farm compared to the reference site. Hence, intensive fish farming offers a suite of physical, chemical and biological modifications of the coastal marine environment which have a detrimental effect on the survivorship of coral juveniles.
Weir, Phil; Ellerweg, Roland; Alhonnoro, Tuomas; Pollari, Mika; Voglreiter, Philip; Mariappan, Panchatcharam; Flanagan, Ronan; Park, Chang Sub; Payne, Stephen; Staerk, Elmar; Voigt, Peter; Moche, Michael; Kolesnik, Marina
The web-based Go-Smart environment is a scalable system that allows the prediction of minimally invasive cancer treatment. Interventional radiologists create a patient-specific 3D model by semi-automatic segmentation and registration of pre-interventional CT (Computed Tomography) and/or MRI (Magnetic Resonance Imaging) images in a 2D/3D browser environment. This model is used to compare patient-specific treatment plans and device performance via built-in simulation tools. Go-Smart includes evaluation techniques for comparing simulated treatment with real ablation lesions segmented from follow-up scans. The framework is highly extensible, allowing manufacturers and researchers to incorporate new ablation devices, mathematical models and physical parameters.
Borgmann, Hendrik; Wölm, Jan-Henning; Vallo, Stefan; Mager, Rene; Huber, Johannes; Breyer, Johannes; Salem, Johannes; Loeb, Stacy; Haferkamp, Axel; Tsaur, Igor
Many patients diagnosed with cancer search for health information on the Web. We aimed to assess the quality and reliability of online health information on prostate cancer. Google, Yahoo, and Bing were searched for the term "prostate cancer." After selecting the most frequented websites, quality was measured by DISCERN score, JAMA benchmark criteria, and presence of HONcode certification. Popularity was assessed by Alexa tool, while accessibility, usability, and reliability were investigated by LIDA tool. Readability was analyzed by Flesch-Kincaid Reading Grade Level and Automated Readability Index. All 13 selected websites were rated as being of high quality according to the DISCERN instrument (76.5 ± 2.6 out of 80 points). JAMA benchmark criteria were fulfilled by 87 % of websites, whereas only 37 % were certified by the HONcode. Median Alexa Traffic Rank was 2718 ranging from 7 to 679,038. Websites received 2.3 ± 0.5 daily pageviews per visitor and users spent an average of 2 min 58 s ± 39 sec on the website. Accessibility (92 ± 5 %) and usability (92 ± 3 %) scores were high and reliability (88 ± 8 %) moderate according to the LIDA tool. Flesch-Kincaid Grade Level was 7.9 ± 2.2, and Automated Readability Index was 7.5 ± 2.4, rating the websites as fairly difficult to read. In conclusion, quality, accessibility, and usability of websites on prostate cancer provided a high rating in the current analysis. These findings are encouraging in view of the growing frequency of patients' access of health information online.
Schwartz Marc D
Full Text Available Abstract Background Whether early detection and treatment of prostate cancer (PCa will reduce disease-related mortality remains uncertain. As a result, tools are needed to facilitate informed decision making. While there have been several decision aids (DAs developed and tested, very few have included an exercise to help men clarify their values and preferences about PCa screening. Further, only one DA has utilized an interactive web-based format, which allows for an expansion and customization of the material. We describe the development of two DAs, a booklet and an interactive website, each with a values clarification component and designed for use in diverse settings. Methods We conducted two feasibility studies to assess men's (45-70 years Internet access and their willingness to use a web- vs. a print-based tool. The booklet was adapted from two previous versions evaluated in randomized controlled trials (RCTs and the website was created to closely match the content of the revised booklet. Usability testing was conducted to obtain feedback regarding draft versions of the materials. The tools were also reviewed by a plain language expert and the interdisciplinary research team. Feedback on the content and presentation led to iterative modifications of the tools. Results The feasibility studies confirmed that the Internet was a viable medium, as the majority of men used a computer, had access to the Internet, and Internet use increased over time. Feedback from the usability testing on the length, presentation, and content of the materials was incorporated into the final versions of the booklet and website. Both the feasibility studies and the usability testing highlighted the need to address men's informed decision making regarding screening. Conclusions Informed decision making for PCa screening is crucial at present and may be important for some time, particularly if a definitive recommendation either for or against screening does not
Skalla, Karen A; Smith, Ellen M Lavoie; Li, Zhongze; Gates, Charlene
This pilot study describes the multidimensional (physical, psychological, social, and spiritual) needs of caregivers of cancer survivors. A regional comprehensive cancer center and nine community-based rural and urban cancer clinics in New Hampshire assembled a convenience sample. Patients with cancer completed an online survey, the cancer survivor Web-based needs assessment survey (CS-WEBS), to identify needs and desire for intervention. Patients then identified a caregiver who was recruited to complete a caregiver version of the CS-WEBS. Caregivers reported challenges within all four domains of the survivorship model. The highest reported physical symptoms were fatigue, insomnia, and weight gain. Social symptoms included financial issues. Although visiting nurse services were the most commonly used resource, many caregivers used no supportive services. The most common caregiver task was listening and talking. Caregivers frequently experienced fatigue, anxiety, and insomnia. Exploring effective ways to alleviate their symptom burden should be a priority. Local and national attention should be directed toward easing the financial burden of caring for a patient with cancer.
Full Text Available Abstract Background To develop and evaluate a continuing medical education (CME course aimed at improving healthcare provider knowledge about breast cancer health disparities and the importance of cross-cultural communication in provider-patient interactions about breast cancer screening. Methods An interactive web-based CME course was developed and contained information about breast cancer disparities, the role of culture in healthcare decision making, and demonstrated a model of cross-cultural communication. A single group pre-/post-test design was used to assess knowledge changes. Data on user satisfaction was also collected. Results In all, 132 participants registered for the CME with 103 completing both assessments. Differences between pre-/post-test show a significant increase in knowledge (70% vs. 94%; p Conclusion There was an overall high level of satisfaction among all users. Users felt that learning objectives were met and the web-based format was appropriate and easy to use and suggests that web-based CME formats are an appropriate tool to teach cultural competency skills. However, more information is needed to understand how the CME impacted practice behaviors.
Liou, Theodore G.; Adler, Frederick R.; FitzSimmons, Stacey C.; Cahill, Barbara C.; Hibbs, Jonathan R.; Marshall, Bruce C.
The objective of this study was to create a 5-year survivorship model to identify key clinical features of cystic fibrosis. Such a model could help researchers and clinicians to evaluate therapies, improve the design of prospective studies, monitor practice patterns, counsel individual patients, and determine the best candidates for lung transplantation. The authors used information from the Cystic Fibrosis Foundation Patient Registry (CFFPR), which has collected longitudinal data on approximately 90% of cystic fibrosis patients diagnosed in the United States since 1986. They developed multivariate logistic regression models by using data on 5,820 patients randomly selected from 11,630 in the CFFPR in 1993. Models were tested for goodness of fit and were validated for the remaining 5,810 patients for 1993. The validated 5-year survivorship model included age, forced expiratory volume in 1 second as a percentage of predicted normal, gender, weight-for-age z score, pancreatic sufficiency, diabetes mellitus, Staphylococcus aureus infection, Burkerholderia cepacia infection, and annual number of acute pulmonary exacerbations. The model provides insights into the complex nature of cystic fibrosis and supplies a rigorous tool for clinical practice and research. PMID:11207152
Parker, Patricia A; Banerjee, Smita C; Matasar, Matthew J; Bylund, Carma L; Franco, Kara; Li, Yuelin; Levin, Tomer T; Jacobsen, Paul B; Astrow, Alan B; Leventhal, Howard; Horwitz, Steven; Kissane, David W
Introduction Survivors of cancer often describe a sense of abandonment post-treatment, with heightened worry, uncertainty, fear of recurrence and limited understanding of what lies ahead. This study examines the efficacy of a communication skills training (CST) intervention to help physicians address survivorship issues and introduce a new consultation focused on the use of a survivorship care plan for patients with Hodgkin's lymphoma and diffuse large B-cell lymphoma. Methods and analysis Specifically, this randomised, 4-site trial will test the efficacy of a survivorship planning consultation (physicians receive CST and apply these skills in a new survivorship-focused office visit using a survivorship plan) with patients who have achieved complete remission after completion of first-line therapy versus a control arm in which physicians are trained to subsequently provide a time-controlled, manualised wellness rehabilitation consultation focused only on discussion of healthy nutrition and exercise as rehabilitation postchemotherapy. The primary outcome for physicians will be uptake and usage of communication skills and maintenance of these skills over time. The primary outcome for patients is changes in knowledge about lymphoma and adherence to physicians’ recommendations (eg, pneumococcus and influenza vaccinations); secondary outcomes will include perceptions of the doctor–patient relationship, decreased levels of cancer worry and depression, quality of life changes, satisfaction with care and usage of healthcare. This study will also examine the moderators and mediators of change within our theoretical model derived from Leventhal's Common-Sense Model of health beliefs. Ethics and dissemination This study was approved by the Institutional Review Boards at Memorial Sloan Kettering Cancer Centers and all other participating sites. This work is funded by the National Cancer Institute (R01 CA 151899 awarded to DWK and SH as coprincipal investigators). The
Irwin, Jeannie Y; Thyvalikakath, Thankam; Schleyer, Titus; Wali, Teena; Kerr, Ross
Background/Aims: In the United States, about 8,000 people a year die from oral cancer and more than 30,000 new cases are diagnosed annually. A recent study showed that 80% of American adult Internet users have searched the Web for health information and 15% of those specifically searched for dental health information. Having high quality oral cancer information available via the Web is important given the significance of this health problem. The goal of this study was to evaluate the quality and content of multiple English and Spanish oral cancer websites. Methods: We developed a search strategy using the keywords: oral cancer, mouth cancer, and tongue cancer to find oral cancer sites via Medline Plus, Google, and Yahoo. We then used the translations cancer oral, cancer de la boca, and cancer de la lengua to search Medline Plus en Español, Google Español, and Yahoo Telemundo. We added sites to the datasets based on inclusion/exclusion criteria. Two native speaking raters evaluated each site within their set for quality using the modified Information Quality Tool (IQT). We then developed a survey tool to asses the content of the sites. Two native speaking oral cancer experts evaluated each site within their set using this new tool. Results: Our search strategy produced 24 English language sites and 24 Spanish language sites for evaluation. English language websites had an average IQT score of 74.7 (out of 100) and average content score of 51.5 (out of 100). Spanish-language sites had an average IQT score of 48.8 and an average content score of 25.9. Conclusions: Despite higher scores for the English language websites, our analysis showed that there was a great variation in overall quality and content with room for improvement for both language types. English sites could make the biggest improvements by providing more information about their sponsors and who controls site content as well as updated and fixing links and author credentials. The Spanish sites should
... Cancer Survivorship ClinicalTrials.gov (1 link) ClinicalTrials.gov Scientific Articles on PubMed (1 link) PubMed OMIM (1 link) BLADDER CANCER Sources for This Page American Cancer Society: What Are the Key Statistics for Bladder Cancer? Bryan RT, Hussain SA, James ...
Nurses historically have used the medical model to assess and intervene when individuals move transitionally into and out of the role of patients with cancer. Although assessing for clinical depression or other medical model designations is appropriate, using this as the sole model for helping patients with cancer emerge from their illness experiences and into the role of survivorship may rob them of the opportunity to actively use the illness for spiritual growth and self-actualization. The transition process is classified into three distinct stages: endings, the neutral zone, and beginnings. Each is characterized by its own unique qualities and challenges. Jungian metaphors and archetypes also can be used to evoke powerful images that help survivors find depth of meaning in their suffering and enhance healing. Nurses often are in ideal positions to create such healing experiences by helping survivors recognize "shadow" emotional experiences stemming from the recovery process, accepting the emotions as normal transitional phenomena, and using them to develop compassion for others. Individuals, therefore, are presented with opportunities to imagine newly emerging life purposes that far exceed their identification as survivors.
Berg, S.W. van den; Gielissen, M.F.M.; Custers, J.A.E.; Graaf, W.T.A. van der; Ottevanger, P.B.; Prins, J.B.
PURPOSE: Early breast cancer survivors (BCSs) report high unmet care needs, and easily accessible care is not routinely available for this growing population. The Breast Cancer E-Health (BREATH) trial is a Web-based self-management intervention to support the psychological adjustment of women after
Zheng, Ling-Ling; Xu, Wei-Lin; Liu, Shun; Sun, Wen-Ju; Li, Jun-Hao; Wu, Jie; Yang, Jian-Hua; Qu, Liang-Hu
tRNA-derived small RNA fragments (tRFs) are one class of small non-coding RNAs derived from transfer RNAs (tRNAs). tRFs play important roles in cellular processes and are involved in multiple cancers. High-throughput small RNA (sRNA) sequencing experiments can detect all the cellular expressed sRNAs, including tRFs. However, distinguishing genuine tRFs from RNA fragments generated by random degradation remains a major challenge. In this study, we developed an integrated web-based computing system, tRF2Cancer, to accurately identify tRFs from sRNA deep-sequencing data and evaluate their expression in multiple cancers. The binomial test was introduced to evaluate whether reads from a small RNA-seq data set represent tRFs or degraded fragments. A classification method was then used to annotate the types of tRFs based on their sites of origin in pre-tRNA or mature tRNA. We applied the pipeline to analyze 10 991 data sets from 32 types of cancers and identified thousands of expressed tRFs. A tool called 'tRFinCancer' was developed to facilitate the users to inspect the expression of tRFs across different types of cancers. Another tool called 'tRFBrowser' shows both the sites of origin and the distribution of chemical modification sites in tRFs on their source tRNA. The tRF2Cancer web server is available at http://rna.sysu.edu.cn/tRFfinder/.
Aloisio, Jason M; Palmer, Matthew I; Giampieri, Mario A; Tuininga, Amy R; Lewis, James D
Plant survivorship depends on biotic and abiotic factors that vary at local and regional scales. This survivorship, in turn, has cascading effects on community composition and the physical structure of vegetation. Survivorship of native plant species is variable among populations planted in environmentally stressful habitats like urban roofs, but the degree to which factors at different spatial scales affect survivorship in urban systems is not well understood. We evaluated the effects of biotic and abiotic factors on survivorship, composition, and physical structure of two native perennial species assemblages, one characterized by a mixture of C4 grasses and forbs (Hempstead Plains, HP) and one characterized by a mixture of C3 grasses and forbs (Rocky Summit, RS), that were initially sown at equal ratios of growth forms (5:1:4; grass, N-fixing forb and non-N-fixing forb) in replicate 2-m(2) plots planted on 10 roofs in New York City (New York, USA). Of 24 000 installed plants, 40% survived 23 months after planting. Within-roof factors explained 71% of variation in survivorship, with biotic (species identity and assemblage) factors accounting for 54% of the overall variation, and abiotic (growing medium depth and plot location) factors explaining 17% of the variation. Among-roof factors explained 29% of variation in survivorship and increased solar radiation correlated with decreased survivorship. While growing medium properties (pH, nutrients, metals) differed among roofs there was no correlation with survivorship. Percent cover and sward height increased with increasing survivorship. At low survivorship, cover of the HP assemblage was greater compared to the RS assemblage. Sward height of the HP assemblage was about two times greater compared to the RS assemblage. These results highlight the effects of local biotic and regional abiotic drivers on community composition and physical structure of green roof vegetation. As a result, initial green roof plant
Stahl, Douglas C; Evans, Richard M; Afrin, Lawrence B; DeTeresa, Richard M; Ko, Dave; Mitchell, Kevin
Electronic discovery of the clinical trials being performed at a specific research center is a challenging task, which presently requires manual review of the center's locally maintained databases or web pages of protocol listings. Near real-time automated discovery of available trials would increase the efficiency and effectiveness of clinical trial searching, and would facilitate the development of new services for information providers and consumers. Automated discovery efforts to date have been hindered by issues such as disparate database schemas, vocabularies, and insufficient standards for easy intersystem exchange of high-level data, but adequate infrastructure now exists that make possible the development of applications for near real-time automated discovery of trials. This paper describes the current state (design and implementation) of the Web Services Specification for Publication and Discovery of Clinical Trials as developed by the Technology Task Force of the Association of American Cancer Institutes. The paper then briefly discusses a prototype web service-based application that implements the specification. Directions for evolution of this specification are also discussed.
“Psychosocial Interventions for Cancer Survivors, Caregivers and Family Members—One Size Does Not Fit All: My Perspective as a Young Adult Survivor, Advocate and Oncology Social Worker” a personal reflection by Mary Grace Bontempo - Office of Cancer Survivorship
“Psychosocial Interventions for Cancer Survivors, Caregivers and Family Members—One Size Does Not Fit All: My Perspective as a Young Adult Survivor, Advocate and Oncology Social Worker” a personal reflection by Mary Grace Bontempo page
DuBenske, Lori L; Gustafson, David H; Shaw, Bret R; Cleary, James F
Over the cancer disease trajectory, from diagnosis and treatment to remission or end of life, patients and their families face difficult decisions. The provision of information and support when most relevant can optimize cancer decision making and coping. An interactive health communication system (IHCS) offers the potential to bridge the communication gaps that occur among patients, family, and clinicians and to empower each to actively engage in cancer care and shared decision making. This is a report of the authors' experience (with a discussion of relevant literature) in developing and testing a Web-based IHCS-the Comprehensive Health Enhancement Support System (CHESS)-for patients with advanced lung cancer and their family caregivers. CHESS provides information, communication, and coaching resources as well as a symptom tracking system that reports health status to the clinical team. Development of an IHCS includes a needs assessment of the target audience and applied theory informed by continued stakeholder involvement in early testing. Critical issues of IHCS implementation include 1) need for interventions that accommodate a variety of format preferences and technology comfort ranges; 2) IHCS user training, 3) clinician investment in IHCS promotion, and 4) IHCS integration with existing medical systems. In creating such comprehensive systems, development strategies need to be grounded in population needs with appropriate use of technology that serves the target users, including the patient/family, clinical team, and health care organization. Implementation strategies should address timing, personnel, and environmental factors to facilitate continued use and benefit from IHCS.
Hibbard, Bruce E; Clark, Thomas L; Ellersieck, Mark R; Meihls, Lisa N; El Khishen, Ahmed A; Kaster, Von; Steiner, Henry-York; Kurtz, Ryan
Mortality of western corn rootworm, Diabrotica virgifera virgifera LeConte, larvae due to MIR604 transgenic corn, Zea mays L., expressing the modified Cry3A (mCry3A) protein relative to survivorship on corn with the same genetic background without the gene (isoline corn) was evaluated at three Missouri sites in both 2005 and 2006. We made these comparisons by using wild-type western corn rootworm at three different egg densities (6,000, 3,000, and 1,500 eggs per m) so that the role of density-dependent mortality would be known. The mortality due to the mCry3A protein was 94.88% when averaged across all environments and both years. Fifty percent emergence of beetles was delayed approximately 5.5 d. Beetles were kept alive and their progeny evaluated on MIR604 and isoline corn in the greenhouse to determine whether survivorship on MIR604 in the field for one generation increased survivorship on MIR604 in the greenhouse in the subsequent generation. There was no significant difference in survivorship on MIR604 in greenhouse assays between larvae whose parents survived isoline and larvae whose parents survived MIR604 in the field the previous generation, indicating that many susceptible beetles survived MIR604 in the field the previous season along with any potentially resistant beetles. The data are discussed in terms of rootworm insect resistance management.
Mortality of western corn rootworm (Diabrotica virgifera virgifera LeConte) larvae due to MIR604 transgenic corn (Zea mays L.) expressing the modified Cry3A (mCry3A) protein relative to survivorship on corn with the same genetic background without the gene (isoline corn) was evaluated at three Misso...
Ricks-Santi, Luisel J; Nie, Jing; Marian, Catalin; Ochs-Balcom, Heather M; Trevisan, Maurizio; Edge, Stephen B; Kanaan, Yasmine; Freudenheim, Jo L; Shields, Peter G
Results of studies for the association of BRCA1 genotypes and haplotypes with sporadic breast cancer have been inconsistent. Therefore, a candidate single nucleotide polymorphism (SNP) approach was used in a breast cancer case-control study to explore genotypes and haplotypes that have the potential to affect protein functions or levels. In a breast cancer case-control study, genotyping of BRCA1 polymorphisms Q356R, D693N, and E1038G was performed on 1,005 cases and 1,765 controls. Unconditional, polytomous logistic regression and χ(2) -tests were used to examine the associations of breast cancer with genotypes and haplotypes. In addition, interactions between genotype and smoking, benign breast disease, family history of breast cancer, body mass index (BMI), alcohol consumption, and hormonal risk factors, hormone receptor status, and breast cancer pathology were calculated also using logistic regression and χ(2) . Although sporadic breast cancer was not associated with BRCA1 genotypes or haplotypes overall or by menopausal status, there was evidence of an interaction between the E1038G BRCA1 genotype, smoking, and BMI among premenopausal women (P for interaction = 0.01 and 0.045, respectively) and between E1038G and D693N BRCA1 genotypes and hormone therapy use among postmenopausal women (P for interaction = 0.01 and 0.02, respectively). There were no other associations found between BRCA1 genotypes and stage, histological grade, or nuclear grade. However, the D693N SNP was associated with the risk of triple negative breast cancer (odds ratio = 2.31 95% confidence interval 1.08-4.93). The BRCA1 variants studied may play a role in the etiology of triple negative breast cancer and may interact with environmental factors such as hormone therapy or smoking and increase sporadic breast cancer risk.
Bolle, S.; Romijn, G.; Smets, E.M.A; Loos, E.F.; Kunneman, M.; van Weert, J.C.M.
We greatly appreciate the thoughtful comments of Gokani and colleagues  in response to our article “Older Cancer Patients’ User Experiences With Web-Based Health Information Tools: A Think-Aloud Study” . We are happy to elaborate on the points for which they request further clarification. Firs
Wheeler, Graham M.; Sweeting, Michael J.; Mander, Adrian P.
In phase I cancer clinical trials, the maximum tolerated dose of a new drug is often found by a dose-escalation method known as the A + B design. We have developed an interactive web application, AplusB, which computes and returns exact operating characteristics of A + B trial designs. The application has a graphical user interface (GUI), requires no programming knowledge and is free to access and use on any device that can open an internet browser. A customised report is available for download for each design that contains tabulated operating characteristics and informative plots, which can then be compared with other dose-escalation methods. We present a step-by-step guide on how to use this application and provide several illustrative examples of its capabilities. PMID:27403961
Wheeler, Graham M; Sweeting, Michael J; Mander, Adrian P
In phase I cancer clinical trials, the maximum tolerated dose of a new drug is often found by a dose-escalation method known as the A + B design. We have developed an interactive web application, AplusB, which computes and returns exact operating characteristics of A + B trial designs. The application has a graphical user interface (GUI), requires no programming knowledge and is free to access and use on any device that can open an internet browser. A customised report is available for download for each design that contains tabulated operating characteristics and informative plots, which can then be compared with other dose-escalation methods. We present a step-by-step guide on how to use this application and provide several illustrative examples of its capabilities.
Graham M Wheeler
Full Text Available In phase I cancer clinical trials, the maximum tolerated dose of a new drug is often found by a dose-escalation method known as the A + B design. We have developed an interactive web application, AplusB, which computes and returns exact operating characteristics of A + B trial designs. The application has a graphical user interface (GUI, requires no programming knowledge and is free to access and use on any device that can open an internet browser. A customised report is available for download for each design that contains tabulated operating characteristics and informative plots, which can then be compared with other dose-escalation methods. We present a step-by-step guide on how to use this application and provide several illustrative examples of its capabilities.
Background Due to advances in the field of oncology, survival rates for children with cancer have improved significantly. However, these childhood cancer survivors are at a higher risk for obesity and cardiovascular diseases and for developing these conditions at an earlier age. Objective In this paper, we describe the rationale, conceptual framework, development process, novel components, and delivery plan of a behavioral intervention program for preventing unhealthy weight gain in survivors...
Parry, Carla; Beckjord, Ellen; Moser, Richard P; Vieux, Sana N; Padgett, Lynne S; Hesse, Bradford W
We report results from the use of an innovative tool (the Grid-Enabled Measures (GEM) database) to drive consensus on the use of measures evaluating the efficacy and implementation of survivorship care plans. The goal of this initiative was to increase the use of publicly available shared measures to enable comparability across studies. Between February and August 2012, research and practice communities populated the GEM platform with constructs and measures relevant to survivorship care planning, rated the measures, and provided qualitative feedback on the quality of the measures. Fifty-one constructs and 124 measures were entered into the GEM-Care Planning workspace by participants. The greatest number of measures appeared in the domains of Health and Psychosocial Outcomes, Health Behaviors, and Coordination of Care/Transitional Care. Using technology-mediated social participation, GEM presents a novel approach to how we measure and improve the quality of survivorship care.
Berg, S.W. van den; Amstel, F.K. Ploos van; Ottevanger, P.B.; Gielissen, M.F.M.; Prins, J.B.
New models of cancer care and survivorship ask for empowered patients. But how do we measure that patients can derive strength from themselves (intrapersonal) and their perceived social support (interpersonal)? The 40-item Cancer Empowerment Questionnaire (CEQ) measures psychological empowerment as
Klug, Hope; Lindström, Kai; St Mary, Colette M
Why should animals knowingly consume their own young? It is difficult to imagine many circumstances in which eating one's own young (i.e., filial cannibalism) actually increases an individual's fitness; however, filial cannibalism commonly co-occurs with parental care in fishes. The evolutionary significance of filial cannibalism remains unclear. The most commonly accepted explanation is that filial cannibalism is a mechanism by which caring males gain energy or nutrients that they reinvest into future reproduction, thereby increasing net reproductive success. There is mixed support for this hypothesis and, at best, it can only explain filial cannibalism in some species. A recent alternative hypothesis suggests that filial cannibalism improves the survivorship of remaining eggs by increasing oxygen availability, and thus increases current reproductive success. This theory has received little attention as of yet. We evaluated the hypothesis of oxygen-mediated filial cannibalism in the sand goby by examining the effect of oxygen and egg density on the occurrence of filial cannibalism, evaluating the effects of partial clutch cannibalism on the survivorship of remaining eggs, and comparing potential costs and benefits of filial cannibalism related to the net number of eggs surviving. Indeed, we found that oxygen level and egg density affected the occurrence of cannibalism and that simulated partial clutch cannibalism improved survivorship of the remaining eggs. Additionally, because increased egg survivorship, stemming from partial egg removal, compensated for the cost of cannibalism (i.e., number of eggs removed) at a range of cannibalism levels, filial cannibalism potentially results in no net losses in reproductive success. However, oxygen did not affect egg survivorship. Thus, we suggest a more general hypothesis of filial cannibalism mediated by density-dependent egg survivorship.
Baili, Paolo; Torresani, Michele; Agresti, Roberto; Rosito, Giuseppe; Daidone, Maria Grazia; Veneroni, Silvia; Cavallo, Ilaria; Funaro, Francesco; Giunco, Marco; Turco, Alberto; Amash, Hade; Scavo, Antonio; Minicozzi, Pamela; Bella, Francesca; Meneghini, Elisabetta; Sant, Milena
In clinical research, many potentially useful variables are available via the routine activity of cancer center-based clinical registries (CCCR). We present the experience of the breast cancer clinical registry at Fondazione IRCCS "Istituto Nazionale dei Tumori" to give an example of how a CCCR can be planned, implemented, and used. Five criteria were taken into consideration while planning our CCCR: (a) available clinical and administrative databases ought to be exploited to the maximum extent; (b) open source software should be used; (c) a Web-based interface must be designed; (d) CCCR data must be compatible with population-based cancer registry data; (e) CCCR must be an open system, able to be connected with other data repositories. The amount of work needed for the implementation of a CCCR is inversely linked with the amount of available coded data: the fewer data are available in the input databases as coded variables, the more work will be necessary, for information technology staff, text mining analysis, and registrars (for collecting data from clinical records). A cancer registry in a comprehensive cancer center can be used for several research aspects, such as estimate of the number of cases needed for clinical studies, assessment of biobank specimens with specific characteristics, evaluation of clinical practice and adhesion to clinical guidelines, comparative studies between clinical and population sets of patients, studies on cancer prognosis, and studies on cancer survivorship.
Seppänen, Matti; Karvonen, Mikko; Virolainen, Petri; Remes, Ville; Pulkkinen, Pekka; Eskelinen, Antti; Liukas, Antti; Mäkelä, Keijo T
Background and purpose In a previous registry report, short-term implant survival of hip resurfacing arthroplasty (HRA) in Finland was found to be comparable to that of total hip arthroplasty (THA). Since then, it has become evident that adverse reactions to metal debris (ARMDs) may also be associated with HRA, not only with large-diameter head metal-on-metal THA. The aim of the study was to assess medium- to long-term survivorship of HRA based on the Finnish Arthroplasty Register (FAR). Patients and methods 5,068 HRAs performed during the period 2001–2013 in Finland were included. Kaplan-Meier survival analysis was used to calculate survival probabilities and their 95% confidence intervals (CIs). Cox multiple regression, with adjustment for age, sex, diagnosis, femoral head size, and hospital volume was used to analyze implant survival of HRA devices with revision for any reason as endpoint. The reference group consisted of 6,485 uncemented Vision/Bimetric and ABG II THAs performed in Finland over the same time period. Results The 8-year survival, with any revision as an endpoint, was 93% (CI: 92–94) for Birmingham Hip Resurfacing (BHR), 86% (CI: 78–94) for Corin, 91% (CI: 89–94) for ReCap, 92% (CI: 89–96) for Durom, and was 72% (CI: 69–76) for the Articular Surface Replacement (ASR). The 10-year survival, with any revision as an endpoint, for reference THAs was 92% (CI: 91–92) and for all HRAs it was 86% (CI: 84–87%). Female HRA patients had about twice the revision risk of male patients. ASR had an inferior outcome: the revision risk was 4-fold higher than for BHR, the reference implant. Interpretation The 10-year implant survival of HRAs is 86% in Finland. According to new recommendations from NICE (The National Institute for Health and Care Excellence), an HRA/THA should have a revision rate of 5% or less at 10 years. None of the HRAs studied achieved this goal. PMID:27759474
Boyes, Allison W; O'Brien, Lorna; Baker, Amanda L; Henskens, Frans A; Clinton-McHarg, Tara; Bellamy, Douglas; Colburn, Glenda; Rose, Shiho; Cox, Martine E; Fradgley, Elizabeth A; Baird, Hannah; Barker, Daniel
Background Community-based services such as telephone support lines can provide valuable informational, emotional, and practical support for cancer patients via telephone- or Web-based (live chat or email) platforms. However, very little rigorous research has examined the efficacy of such services in improving patient outcomes. Objective This study will determine whether: proactive telephone or Web-delivered support produces outcomes superior to printed information; and Web-delivered support produces outcomes comparable to telephone support. Methods A consecutive sample of 501 lung cancer outpatients will be recruited from 50 Australian health services to participate in a patient-randomized controlled trial (RCT). Eligible individuals must: be 18 years or older; have received a lung cancer diagnosis (including mesothelioma) within the previous 4 months; have an approximate life expectancy of at least 6 months; and have Internet access. Participants will be randomly allocated to receive: (1) an information booklet, (2) proactive telephone support, or (3) proactive Web support, chat, and/or email. The primary patient outcomes will be measured by the General Health Questionnaire (GHQ-12) and Health Education and Impact Questionnaire (heiQ) at 3 and 6 months post recruitment. The acceptability of proactive recruitment strategies will also be assessed. Results It is hypothesized that participants receiving telephone or Web support will report reduced distress (GHQ-12 scores that are 0.3 standard deviations (SD) lower) and greater self-efficacy (heiQ scores that are 0.3 SDs higher) than participants receiving booklets. Individuals receiving Web support will report heiQ scores within 0.29 SDs of individuals receiving telephone support. Conclusions If proven effective, electronic approaches such as live-chat and email have the potential to increase the accessibility and continuity of supportive care delivered by community-based services. This evidence may also inform the
Arik, Anam J; Hun, Lewis V; Quicke, Kendra; Piatt, Michael; Ziegler, Rolf; Scaraffia, Patricia Y; Badgandi, Hemant; Riehle, Michael A
Akt signaling regulates diverse physiologies in a wide range of organisms. We examine the impact of increased Akt signaling in the fat body of 2 mosquito species, the Asian malaria mosquito Anopheles stephensi and the yellow fever mosquito Aedes aegypti. Overexpression of a myristoylated and active form of A. stephensi and Ae. aegypti Akt in the fat body of transgenic mosquitoes led to activation of the downstream signaling molecules forkhead box O (FOXO) and p70 S6 kinase in a tissue and blood meal-specific manner. In both species, increased Akt signaling in the fat body after blood feeding significantly increased adult survivorship relative to nontransgenic sibling controls. In A. stephensi, survivorship was increased by 15% to 45%, while in Ae. aegypti, it increased 14% to 47%. Transgenic mosquitoes fed only sugar, and thus not expressing active Akt, had no significant difference in survivorship relative to nontransgenic siblings. Expression of active Akt also increased expression of fat body vitellogenin, but the number of viable eggs did not differ significantly between transgenic and nontransgenic controls. This work demonstrates a novel mechanism of enhanced survivorship through increased Akt signaling in the fat bodies of multiple mosquito genera and provides new tools to unlock the molecular underpinnings of aging in eukaryotic organisms.
Huerga, Iker; Gerrikagoitia, Jon Kepa
Risk estimation of developing breast cancer poses as the first prevention method for early diagnosis. Furthermore, data integration from different departments involved in the process plays a key role. In order to guarantee patient safety, the whole process should be orchestrated and monitored automatically. Support for the solution will be a linked data cloud, composed by all the departments that take part in the process, combined with rule engines.
Wefel, Jeffrey S.; Vidrine, Damon J.; Veramonti, Tracy L.; Meyers, Christina A.; Marani, Salma K.; Hoekstra, Harald J.; Hoekstra-Weebers, Josette E. H. M.; Shahani, Lokesh; Gritz, Ellen R.
BACKGROUND: Cognitive dysfunction experienced by individuals with cancer represents an important survivorship issue because of its potential to affect occupational, scholastic, and social activities. Whereas early efforts to characterize cognitive dysfunction primarily focused on the effects of chem
Manrique-Saide, P; Ibáñez-Bernal, S; Delfín-González, H; Parra Tabla, V
The effect of the introduction of the entomophagous copepod Mesocyclops longisetus (Acuacultura F.C.B. strain) on the survival of Aedes aegypti immature stages in car tyres was evaluated under semi-natural conditions in the municipality of Merida, Yucatan, Mexico. Life tables were constructed for the immature stages of the mosquito in the presence and absence of M. longisetus, and the survival data were compared using log-linear models. The data set was adjusted using the GLIM statistical package and the quality of adjustment was evaluated with a chi-squared test. Survivorship curves were constructed for each treatment. In the absence of M. longisetus, the survivorship of Ae. aegypti immature stages averaged 9%. The highest mortality rate was observed during the fourth larval instar (54%) and the resulting survival pattern corresponded to a type II survivorship curve. The mortality rate of Ae. aegypti first-instar larvae (fifty per tyre) increased more than 200-fold in the presence of M. longisetus (twenty per tyre) and the highest mortality was during the first two larval instars, where it reached 98.9%, with a resulting survivorship of 0.2%. Overall mortality was sixfold greater in the presence of the copepod than in its absence. The survival pattern of immature stages of Ae. aegypti in the presence of the copepod corresponded to a type III survivorship curve. As M. longisetus was so effective against Ae. aegypti immature stages in tyres under seminatural conditions, its long-term effectiveness should be evaluated under socially and ecologically realistic field conditions in Mexico.
Sisler, Jeffrey; Chaput, Genevieve; Sussman, Jonathan; Ozokwelu, Emmanuel
Objective To offer FPs a summary of evidence-based recommendations to guide their follow-up survivorship care of women treated for breast cancer. Quality of evidence A literature search was conducted in MEDLINE from 2000 to 2016 using the search words breast cancer, survivorship, follow-up care, aftercare, guidelines, and survivorship care plans, with a focus on review of recent guidelines published by national cancer organizations. Evidence ranges from level I to level III. Main message Survivorship care involves 4 main tasks: surveillance and screening, management of long-term effects, health promotion, and care coordination. Surveillance for recurrence involves only annual mammography, and screening for other cancers should be done according to population guidelines. Management of the long-term effects of cancer and its treatment addresses common issues of pain, fatigue, lymphedema, distress, and medication side effects, as well as longer-term concerns for cardiac and bone health. Health promotion emphasizes the benefits of active lifestyle change in cancer survivors, with an emphasis on physical activity. Survivorship care is enhanced by the involvement of various health professionals and services, and FPs play an important role in care coordination. Conclusion Family physicians are increasingly the main providers of follow-up care after breast cancer treatment. Breast cancer should be viewed as a chronic medical condition even in women who remain disease free, and patients benefit from the approach afforded other chronic conditions in primary care. PMID:27737976
Ulloa, Jesus G.; Hemmelgarn, Marian; Viveros, Lori; Odele, Patience; Feldman, Nancy R.; Ganz, Patricia A.; Maggard-Gibbons, Melinda
Background Low-income, minority women with breast cancer experience a range of barriers to receiving survivorship information. Our objective was to test a novel, patient-centered intervention aimed at improving communication about survivorship care. Methods We developed a wallet card to provide oncologic and follow-up care survivorship information to breast cancer patients. We used a prospective, pre–post design to assess the intervention at a safety net hospital. The intervention was given by a patient navigator or community health worker. Results Patient knowledge (n = 130) of personal cancer history improved from baseline pretest to 1 week after the intervention for stage (66–93%; P < .05), treatment (79–92%; P < .05), and symptoms of recurrence (48–89%; P <.05), which was retained at 3 months. The intervention reduced the number of patients who were unsure when their mammogram was due (15–5% at 1 week and 6%at 3 months; P <.05). Nearly 90% reported they would be likely to share their survivorship card with their providers. Conclusion A patient-centered survivorship card improved short-term recall of key survivorship care knowledge and seems to be effective at reducing communication barriers for this population. Further studies are warranted to assess long-term retention and the impact on receipt of appropriate survivorship follow-up care. PMID:26032819
Beyer, Jürgen; Albers, Peter Hjorth; Altena, R;
In November 2011, the Third European Consensus Conference on Diagnosis and Treatment of Germ-Cell Cancer (GCC) was held in Berlin, Germany. This third conference followed similar meetings in 2003 (Essen, Germany) and 2006 (Amsterdam, The Netherlands) [Schmoll H-J, Souchon R, Krege S et al. Europe...
... cancer Non-Hodgkin lymphoma Ovarian cancer Pancreatic cancer Testicular cancer Thyroid cancer Uterine cancer Symptoms Symptoms of cancer ... tumor Obesity Pancreatic cancer Prostate cancer Stomach cancer Testicular cancer Throat or larynx cancer Thyroid cancer Patient Instructions ...
Gray, Stacy W; Cronin, Angel; Bair, Elizabeth; Lindeman, Neal; Viswanath, Vish; Janeway, Katherine A
Internet marketing may accelerate the use of care based on genomic or tumor-derived data. However, online marketing may be detrimental if it endorses products of unproven benefit. We conducted an analysis of Internet websites to identify personalized cancer medicine (PCM) products and claims. A Delphi Panel categorized PCM as standard or nonstandard based on evidence of clinical utility. Fifty-five websites, sponsored by commercial entities, academic institutions, physicians, research institutes, and organizations, that marketed PCM included somatic (58%) and germline (20%) analysis, interpretive services (15%), and physicians/institutions offering personalized care (44%). Of 32 sites offering somatic analysis, 56% included specific test information (range 1-152 tests). All statistical tests were two-sided, and comparisons of website content were conducted using McNemar's test. More websites contained information about the benefits than limitations of PCM (85% vs 27%, P analysis were statistically significantly more likely to market one or more nonstandard tests as compared with standard tests (88% vs 44%, P = .04).
Liu, Yong-Biao; Liu, Samuel S; Simmons, Gregory; Walse, Spencer S; Myers, Scott W
Light brown apple moth, Epiphyas postvittana (Walker), eggs were subjected to phosphine fumigations under normal atmospheric and elevated oxygen levels in laboratory-scale chamber experiments to compare their susceptibilities to the two different fumigation methods. In fumigations conducted under atmospheric oxygen at 5 and 10 degrees C, egg survivorship decreased with increase in phosphine concentration but then increased at a concentration of 3,000 ppm; this increase was significant at 10 degrees C. Based on egg survivorship data, phosphine fumigations conducted in a 60% oxygen atmosphere were significantly more effective than those conducted under atmospheric oxygen conditions. Oxygenated phosphine fumigations at 5 and 10 degrees C killed all 1,998 and 2,213 E. postvittana eggs treated, respectively, after 72 h of exposure. These results indicate the great potential of oxygenated phosphine fumigation for the control of E. postvittana eggs.
Hanley, Torrance C; Hughes, A Randall; Williams, Bethany; Garland, Hanna; Kimbro, David L
Intraspecific diversity, particularly of foundation species, can significantly affect population, community, and ecosystem processes. Examining how genetic diversity relates to demographic traits provides a key mechanistic link from genotypic and phenotypic variation of taxa with complex life histories to their population dynamics. We conducted a field experiment to assess how two metrics of intraspecific diversity (cohort diversity, the number of independent juvenile cohorts created from different adult source populations, and genetic relatedness, genetic similarity among individuals within and across cohorts) affect the survivorship, growth, and recruitment of the foundation species Crassostrea virginica. To assess the effects of both cohort diversity and genetic relatedness on oyster demographic traits under different environmental conditions, we manipulated juvenile oyster diversity and predator exposure (presence/absence of a cage) at two sites differing in resource availability and predation intensity. Differences in predation pressure between sites overwhelmingly determined post-settlement survivorship of oysters. However, in the absence of predation (i.e., cage treatment), one or both metrics of intraspecific diversity, in addition to site, influenced long-term survivorship, growth, and recruitment. While both cohort diversity and genetic relatedness were negatively associated with long-term survivorship, genetic relatedness alone showed a positive association with growth and cohort diversity alone showed a positive association with recruitment. Thus, our results demonstrate that in the absence of predation, intraspecific diversity can affect multiple demographic traits of a foundation species, but the relative importance of these effects depends on the environmental context. Moreover, the magnitude and direction of these effects vary depending on the diversity metric, cohort diversity or genetic relatedness, suggesting that although they are inversely
Sénégas, Jacques; Vital, Jean-Marc; Pointillart, Vincent; Mangione, Paolo
In 1986, an interspinous dynamic stabilization system (the prototype of the current Wallis implant) was designed to stiffen unstable operated degenerate lumbar segments with a hard interspinous blocker to limit extension and a tension band around the spinous processes to secure the implant and limit flexion. Restoring physiological mechanical conditions to the treated level(s) while preserving some intervertebral mobility was intended to treat low-back pain related to degenerative instability without increasing stress forces in the adjacent segments. The procedure was easily reversible. If low back pain persisted or recurred, the device was removed and stability was achieved using fusion. The intermediate-term results were promising, but the long-term safety and efficacy of this dynamic interspinous stabilization device has not been previously documented. We retrospectively reviewed the hospital files of all the patients (n = 241) who had this dynamic stabilization system implanted between 1987 and 1995, contacting as many as possible to determine the actuarial survivorship of the system. In this manner, 142 of the 241 patients (58.9%) were contacted by telephone. The endpoints used for the survivorship analysis were 'any subsequent lumbar operation' and 'implant removal'. At 14 years follow-up, values of actuarial survivorship with 95% confidence interval were 75.9 +/- 8.3 and 81.3 +/- 6.8% for the endpoints 'any subsequent lumbar operation' and 'implant removal', respectively. There was no difference in survivorship of multiple-level implants with respect to single-level devices. Although the conclusions of the present study must be tempered by the 41% attrition rate, these findings support the long-term safety of this system, and possibly long-term protective action against adjacent-level degeneration by motion preservation. Outcomes at least equivalent to those of fusion were observed without the primary drawbacks of fusion.
Foster, Claire; Grimmett, Chloe; May, Christine M.; Ewings, Sean; Myall, Michelle; Hulme, Claire; Smith, Peter W.; Powers, Cassandra; Calman, Lynn; Armes, Jo; Breckons, Matthew; Corner, Jessica; Fenlon, Deborah; Batehup, Lynn; Lennan, Elaine
Purpose: Cancer-related fatigue (CRF) is a frequent and distressing symptom experienced after cancer treatment. RESTORE is the first web-based resource designed to enhance self-efficacy to manage CRF following curative-intent treatment. The aim of this study is to test the proof of concept and inform the design of an effectiveness trial.\\ud \\ud Methods: A multi-centre parallel-group two-armed (1:1) exploratory randomised controlled trial (RCT) with qualitative process evaluation was employed ...
Arving, Cecilia; Wadensten, Barbro; Johansson, Birgitta
Purpose of the research was to describe registered nurses' (RNs) (n = 53) thoughts on the blended learning format in a 'specialist nursing programme in cancer care'. The study was conducted in autumn 2007 and 2008. A content analysis of answers to open-ended questions in a web-based questionnaire and a focus group interview were carried out. The analysis revealed that the RNs appreciated blended learning. The web lectures facilitated learning and gave RNs access to the education at any time. However, according to the RNs, knowledge is gained through interaction between RNs and teachers, and this aspect needed to be improved. The RNs also thought that the content of the seminars on campus should focus on evidence-based nursing knowledge and practical skills, not just taught as stable facts and procedures. The result from the present study could help to improve the design and content of advanced nursing courses using a blended learning format.
Cadmus-Bertram, Lisa; Nelson, Sandahl H; Hartman, Sheri; Patterson, Ruth E; Parker, Barbara A; Pierce, John P
Excess weight and physical inactivity are modifiable risk factors for breast cancer. Behavioral intervention is particularly important among women with an elevated risk profile. This trial tested an intervention that trained women to use a self-monitoring website to increase activity and lose weight. Women with BMI ≥27.5 kg/m(2) at elevated breast cancer risk were randomized to the intervention (N = 71) or usual care (N = 34). The intervention group received telephone-based coaching and used web-based self-monitoring tools. At 6 months, significant weight loss was observed in the intervention group (4.7 % loss from starting weight; SD = 4.7 %) relative to usual care (0.4 % gain; SD = 3.0 %) (p web- and phone-based approach produced modest but significant improvements in weight and physical activity for women at elevated breast cancer risk.
Ribisl, Kurt M; Fernandez, Maria E; Friedman, Daniela B; Hannon, Peggy A; Leeman, Jennifer; Moore, Alexis; Olson, Lindsay; Ory, Marcia; Risendal, Betsy; Sheble, Laura; Taylor, Vicky M; Williams, Rebecca S; Weiner, Bryan J
The Cancer Prevention and Control Research Network (CPCRN) is a thematic network dedicated to accelerating the adoption of evidence-based cancer prevention and control practices in communities by advancing dissemination and implementation science. Funded by the Centers for Disease Control and Prevention and National Cancer Institute, CPCRN has operated at two levels: Each participating network center conducts research projects with primarily local partners as well as multicenter collaborative research projects with state and national partners. Through multicenter collaboration, thematic networks leverage the expertise, resources, and partnerships of participating centers to conduct research projects collectively that might not be feasible individually. Although multicenter collaboration is often advocated, it is challenging to promote and assess. Using bibliometric network analysis and other graphical methods, this paper describes CPCRN's multicenter publication progression from 2004 to 2014. Searching PubMed, Scopus, and Web of Science in 2014 identified 249 peer-reviewed CPCRN publications involving two or more centers out of 6,534 total. The research and public health impact of these multicenter collaborative projects initiated by CPCRN during that 10-year period were then examined. CPCRN established numerous workgroups around topics such as: 2-1-1, training and technical assistance, colorectal cancer control, federally qualified health centers, cancer survivorship, and human papillomavirus. This paper discusses the challenges that arise in promoting multicenter collaboration and the strategies that CPCRN uses to address those challenges. The lessons learned should broadly interest those seeking to promote multisite collaboration to address public health problems, such as cancer prevention and control.
McKibbin, René; Dushenko, William T; vanAggelen, Graham; Bishop, Christine A
In Canada, the Oregon spotted frog (Rana pretiosa) is a critically endangered species with only three known populations and an estimated breeding population of less than 400 located in isolated sites in the extreme south-west corner of British Columbia. Floating Nitex cages were used to assess embryonic survivorship in two populations of Oregon spotted frogs from 2002-2005. One population, near Aldergrove, BC experienced declines in population size while the other population, at Maria Slough, increased during the period 1997-2001. During embryo development, we measured trace metals, nutrients and physical parameters in the water at each site. These were used to test the hypothesis that water quality parameters were correlated with embryonic survivorship. During the study period in the declining population at Aldergrove R. pretiosa bred at two distinct sub sites (A and B) located 500 m apart within the wetland. Mean embryonic survivorship varied from 9% to 36% at sub site A and from 78% to 88% at sub site B whereas in the population in Maria Slough, the mean embryonic survivorship varied from 77% to 84%. Sulphate was the only water chemistry variable that differed significantly between the two study sites and was the highest at Maria Slough. A weak significant positive correlation was found between chloride and embryonic survivorship and conductivity and embryonic survivorship. A multiple regression model found conductivity was the only significant variable. We concluded that natural water chemistry conditions of low chloride and consequently low conductivity may be contributing to low embryonic survivorship in the population of R. pretiosa at MD Aldergrove, BC.
Full Text Available Abstract Background A real-time clinical decision support system (RTCDSS with interactive diagrams enables clinicians to instantly and efficiently track patients' clinical records (PCRs and improve their quality of clinical care. We propose a RTCDSS to process online clinical informatics from multiple databases for clinical decision making in the treatment of prostate cancer based on Web Model-View-Controller (MVC architecture, by which the system can easily be adapted to different diseases and applications. Methods We designed a framework upon the Web MVC-based architecture in which the reusable and extractable models can be conveniently adapted to other hospital information systems and which allows for efficient database integration. Then, we determined the clinical variables of the prostate cancer treatment based on participating clinicians' opinions and developed a computational model to determine the pretreatment parameters. Furthermore, the components of the RTCDSS integrated PCRs and decision factors for real-time analysis to provide evidence-based diagrams upon the clinician-oriented interface for visualization of treatment guidance and health risk assessment. Results The resulting system can improve quality of clinical treatment by allowing clinicians to concurrently analyze and evaluate the clinical markers of prostate cancer patients with instantaneous clinical data and evidence-based diagrams which can automatically identify pretreatment parameters. Moreover, the proposed RTCDSS can aid interactions between patients and clinicians. Conclusions Our proposed framework supports online clinical informatics, evaluates treatment risks, offers interactive guidance, and provides real-time reference for decision making in the treatment of prostate cancer. The developed clinician-oriented interface can assist clinicians in conveniently presenting evidence-based information to patients and can be readily adapted to an existing hospital
Shats, Oleg; Goldner, Whitney; Feng, Jianmin; Sherman, Alexander; Smith, Russell B; Sherman, Simon
A multicenter, web-based Thyroid Cancer and Tumor Collaborative Registry (TCCR, http://tccr.unmc.edu) allows for the collection and management of various data on thyroid cancer (TC) and thyroid nodule (TN) patients. The TCCR is coupled with OpenSpecimen, an open-source biobank management system, to annotate biospecimens obtained from the TCCR subjects. The demographic, lifestyle, physical activity, dietary habits, family history, medical history, and quality of life data are provided and may be entered into the registry by subjects. Information on diagnosis, treatment, and outcome is entered by the clinical personnel. The TCCR uses advanced technical and organizational practices, such as (i) metadata-driven software architecture (design); (ii) modern standards and best practices for data sharing and interoperability (standardization); (iii) Agile methodology (project management); (iv) Software as a Service (SaaS) as a software distribution model (operation); and (v) the confederation principle as a business model (governance). This allowed us to create a secure, reliable, user-friendly, and self-sustainable system for TC and TN data collection and management that is compatible with various end-user devices and easily adaptable to a rapidly changing environment. Currently, the TCCR contains data on 2,261 subjects and data on more than 28,000 biospecimens. Data and biological samples collected by the TCCR are used in developing diagnostic, prevention, treatment, and survivorship strategies against TC.
Martin, Michelle Y.; EVANS, MARY B.; Kratt, Polly; Pollack, Lori A.; SMITH, JUDITH LEE; Oster, Robert; Dignan, Mark; Prayor-Patterson, Heather; Watson, Christopher; Houston, Peter; ANDREWS, SHIQUINA; LIWO, AMANDIY; TSENG, TUNG SUNG; Hullett, Sandral; OLIVER, JOANN
The American Cancer Society is a leader in the development of cancer survivorship resources. One resource of the American Cancer Society is the I Can Cope program, an educational program for cancer survivors and their families. Evaluations of this program indicate that cancer patients highly rate its objectives. Yet, there are gaps in the understanding of the full impact of the program on diverse cancer survivors. In this study, the authors used a randomized trial to evaluate the program. Par...
Gamble, Gail L; Gerber, Lynn H; Spill, Gayle R; Paul, Kelly L
In this article, the subject of the future for the field of cancer rehabilitation is embarked upon. Future practice innovation models must involve the appropriate and comprehensive evaluation of cancer patients' rehabilitation needs using better functional measurement tools, as well as the forging of new partnerships through the presence and initiation of physiatric coordinated rehabilitation teams, particularly during the acute phases of treatment. Partnering rehabilitation teams closely with oncology colleagues during surveillance years, through the development of outpatient survivorship clinics for diagnosis and treatment of many of cancer patients' ongoing symptoms and functional limitations, will allow for more comprehensive and coordinated follow-up cancer care. Integration of rehabilitation into palliative care and continued efforts to increase oncology's awareness and acceptance of rehabilitation benefits and expertise are needed. Future education models for medical school, residency, and postresidency training are discussed, as are future research goals to help in placing cancer rehabilitation at the forefront of acute cancer care and survivorship care.
Perceived Barriers and Facilitators of Using a Web-Based Interactive Decision Aid for Colorectal Cancer Screening in Community Practice Settings: Findings From Focus Groups With Primary Care Clinicians and Medical Office Staff
Background Information is lacking about the capacity of those working in community practice settings to utilize health information technology for colorectal cancer screening. Objective To address this gap we asked those working in community practice settings to share their perspectives about how the implementation of a Web-based patient-led decision aid might affect patient-clinician conversations about colorectal cancer screening and the day-to-day clinical workflow. Methods Five focus group...
Hernández-Martínez, Salvador; Mayoral, Jaime G; Li, Yiping; Noriega, Fernando G
Teneral reserves are utilized to initiate previtellogenic ovarian development in mosquitoes. Females having emerged with low teneral reserves have reduced juvenile hormone (JH) synthesis and previtellogenic development. We investigated what role JH, allatotropin (AT) and other head-factors play in the regulation of previtellogenic ovarian development and adult survivorship. Factors from the head are essential for corpora allata (CA) activation and reproductive maturation. We have shown that decapitation of females within 9-12h after adult ecdysis prevented normal development of the previtellogenic follicles; however maximum previtellogenic ovarian development could be induced in decapitated females by topically applying a JH analog. When females were decapitated 12 or more hours after emergence nutritional resources had been committed to ovarian development and survivorship was significantly reduced. To study if allatotropin levels correlated with teneral reserves, we measured AT titers in the heads of two adult phenotypes (large and small females) generated by raising larvae under different nutritional diets. In large mosquitoes AT levels increased to a maximum of 45 fmol in day 4; in contrast, the levels of allatotropin in the heads of small mosquitoes remained below 9 fmol during the 7 days evaluated. These results suggest that only when nutrients are appropriate, factors released from the brain induce the CA to synthesize enough JH to activate reproductive maturation.
Rising, C.J.; Bol, N.; Kreps, G.L.
Background: Men with prostate cancer require ample information and support along the continuum of care, and eHealth is one way to meet such critical information and support needs. Currently, evidence about how age influences use and perceptions about prostate cancer eHealth information and support i
The University of Arizona Artificial Intelligence Lab (AI Lab) Dark Web project is a long-term scientific research program that aims to study and understand the international terrorism (Jihadist) phenomena via a computational, data-centric approach. We aim to collect "ALL" web content generated by international terrorist groups, including web sites, forums, chat rooms, blogs, social networking sites, videos, virtual world, etc. We have developed various multilingual data mining, text mining, and web mining techniques to perform link analysis, content analysis, web metrics (technical
Lopez-Doriga, Adriana; Feliubadaló, Lídia; Menéndez, Mireia; Lopez-Doriga, Sergio; Morón-Duran, Francisco D; del Valle, Jesús; Tornero, Eva; Montes, Eva; Cuesta, Raquel; Campos, Olga; Gómez, Carolina; Pineda, Marta; González, Sara; Moreno, Victor; Capellá, Gabriel; Lázaro, Conxi
Next-generation sequencing (NGS) has revolutionized genomic research and is set to have a major impact on genetic diagnostics thanks to the advent of benchtop sequencers and flexible kits for targeted libraries. Among the main hurdles in NGS are the difficulty of performing bioinformatic analysis of the huge volume of data generated and the high number of false positive calls that could be obtained, depending on the NGS technology and the analysis pipeline. Here, we present the development of a free and user-friendly Web data analysis tool that detects and filters sequence variants, provides coverage information, and allows the user to customize some basic parameters. The tool has been developed to provide accurate genetic analysis of targeted sequencing of common high-risk hereditary cancer genes using amplicon libraries run in a GS Junior System. The Web resource is linked to our own mutation database, to assist in the clinical classification of identified variants. We believe that this tool will greatly facilitate the use of the NGS approach in routine laboratories.
Stahl, Douglas C.; Evans, Richard M.; Afrin, Lawrence B.; DeTeresa, Richard M.; Ko, Dave; Mitchell, Kevin
Electronic discovery of the clinical trials being performed at a specific research center is a challenging task, which presently requires manual review of the center’s locally maintained databases or web pages of protocol listings. Near real-time automated discovery of available trials would increase the efficiency and effectiveness of clinical trial searching, and would facilitate the development of new services for information providers and consumers. Automated discovery efforts to date hav...
González-Díaz, Humberto; Munteanu, Cristian R; Postelnicu, Lucian; Prado-Prado, Francisco; Gestal, Marcos; Pazos, Alejandro
Lipid-Binding Proteins (LIBPs) or Fatty Acid-Binding Proteins (FABPs) play an important role in many diseases such as different types of cancer, kidney injury, atherosclerosis, diabetes, intestinal ischemia and parasitic infections. Thus, the computational methods that can predict LIBPs based on 3D structure parameters became a goal of major importance for drug-target discovery, vaccine design and biomarker selection. In addition, the Protein Data Bank (PDB) contains 3000+ protein 3D structures with unknown function. This list, as well as new experimental outcomes in proteomics research, is a very interesting source to discover relevant proteins, including LIBPs. However, to the best of our knowledge, there are no general models to predict new LIBPs based on 3D structures. We developed new Quantitative Structure-Activity Relationship (QSAR) models based on 3D electrostatic parameters of 1801 different proteins, including 801 LIBPs. We calculated these electrostatic parameters with the MARCH-INSIDE software and they correspond to the entire protein or to specific protein regions named core, inner, middle, and surface. We used these parameters as inputs to develop a simple Linear Discriminant Analysis (LDA) classifier to discriminate 3D structure of LIBPs from other proteins. We implemented this predictor in the web server named LIBP-Pred, freely available at , along with other important web servers of the Bio-AIMS portal. The users can carry out an automatic retrieval of protein structures from PDB or upload their custom protein structural models from their disk created with LOMETS server. We demonstrated the PDB mining option performing a predictive study of 2000+ proteins with unknown function. Interesting results regarding the discovery of new Cancer Biomarkers in humans or drug targets in parasites have been discussed here in this sense.
Munteanu, Cristian R; Pedreira, Nieves; Dorado, Julián; Pazos, Alejandro; Pérez-Montoto, Lázaro G; Ubeira, Florencio M; González-Díaz, Humberto
Lectins (Ls) play an important role in many diseases such as different types of cancer, parasitic infections and other diseases. Interestingly, the Protein Data Bank (PDB) contains +3000 protein 3D structures with unknown function. Thus, we can in principle, discover new Ls mining non-annotated structures from PDB or other sources. However, there are no general models to predict new biologically relevant Ls based on 3D chemical structures. We used the MARCH-INSIDE software to calculate the Markov-Shannon 3D electrostatic entropy parameters for the complex networks of protein structure of 2200 different protein 3D structures, including 1200 Ls. We have performed a Linear Discriminant Analysis (LDA) using these parameters as inputs in order to seek a new Quantitative Structure-Activity Relationship (QSAR) model, which is able to discriminate 3D structure of Ls from other proteins. We implemented this predictor in the web server named LECTINPred, freely available at http://bio-aims.udc.es/LECTINPred.php. This web server showed the following goodness-of-fit statistics: Sensitivity=96.7 % (for Ls), Specificity=87.6 % (non-active proteins), and Accuracy=92.5 % (for all proteins), considering altogether both the training and external prediction series. In mode 2, users can carry out an automatic retrieval of protein structures from PDB. We illustrated the use of this server, in operation mode 1, performing a data mining of PDB. We predicted Ls scores for +2000 proteins with unknown function and selected the top-scored ones as possible lectins. In operation mode 2, LECTINPred can also upload 3D structural models generated with structure-prediction tools like LOMETS or PHYRE2. The new Ls are expected to be of relevance as cancer biomarkers or useful in parasite vaccine design.
Links, Matthew; Sargeant, Chris; Waters, Amy; Liauw, Winston; Thomas, Patrice
There is an urgent need for efficient cancer education programmes to promote safe practice in a comprehensive cancer centre. Educational practice has developed historically in an unplanned and inefficient way. Developments in educational theory and information technology provide an opportunity to develop systems with better educational methodology, better efficiency and potential for better impact on safety outcomes. We have developed such a programme at St. George Comprehensive Cancer Centre in Sydney, Australia, and describe here our experience in the first 2 years of implementing such a programme. In this article, we describe the programme, the obstacles and solutions we encountered and our reflections on the journey so far.
de Rooij, B.H.; Ezendam, N.P.M.; Nicolaije, K.A.H.; Vos, M.C.; Pijnenborg, J.M.A.; Boll, Dorry; Kruitwagen, R.F.P.M.; van de Poll-Franse, L.V.
Purpose The aim of this study is to investigate the factors that influence implementation of Survivorship Care Plans (SCPs) in the intervention arm of the ROGY Care trial by (1) assessing the level of SCP receipt in the ROGY Care trial and (2) identifying patient- and provider-level factors that inf
Vroom, P.S.; Smith, C.M.; Coyer, J.A.; Walters, L.; Hunter, C.L.; Beach, K.S.; Smith, J.E.
Growth, survivorship, recruitment, and reproduction of Halimeda tuna, a dominant green alga in many reef systems of the Florida Keys, were monitored at a shallow back reef ( 4 - 7m) and deep reef slope ( 15 - 22 m) on Conch Reef. Despite lower light intensities and similar grazing pressures, amphipo
Mazack, Jane E.; Kranzfelder, Petra; Anderson, Alyssa M.; Bouchard, William; Perry, James; Vondracek, Bruce C.; Ferrington, Leonard C.
Diamesa mendotae Muttkowski, 1915 is a winter-active species common in groundwater-buffered streams of Minnesota and Wisconsin. This species is capable of surviving under snow cover for at least 28 days. Field collections of adult D. mendotae were used to determine survivorship under long-term exposure to controlled sub-freezing conditions. Specimens were placed into a controlled temperature chamber at −5 °C, batches removed at weekly intervals, and subsequently held at 6 °C to determine survivorship and longevity. Our results indicate that overall survivorship is negatively related to treatment duration of sub-freezing treatment, individuals can survive sub-freezing temperatures for at least 70 days, with total longevity of 92 days. Additionally, males had a significantly higher rate of survivorship than females within treatments. Total longevity increased with treatment time, suggesting adult D. mendotae may survive long periods of below-freezing temperatures under natural conditions before mating, which may convey population-level advantages.
Una sobreviviente de cÃ¡ncer comparte su historia sobre el diagnÃ³stico, el tratamiento y el apoyo de su comunidad; ella tambiÃ©n les da consejos a otros sobrevivientes de cÃ¡ncer. Created: 10/20/2016 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP). Date Released: 3/15/2017.
Beattie, Jill; Brady, Lisa; Tobias, Tracey
Lean thinking and quality improvement processes identified a need to develop and implement a short concise web-based program for clinicians to increase their confidence and skills in supportive care screening of cancer patients. An independent pretest-posttest design evaluated the program which consisted of three modules, a self-directed learning quiz, and multimedia. Questionnaires were completed anonymously via SurveyMonkey®. There was an increase in mean scores from pre- to post-program in perceived knowledge (pre M = 1.97 SD = .847; post M = 3.05 SD = .486; 3 months M = 2.72 SD = .575), educational preparedness (pre M = 2.33 SD = .957; post M = 3.45 SD = .510; 3 months M = 3.05 SD = .486), and confidence (pre M = 2.39 SD = .998; post M = 3.32 SD = .646; 3 months M = 3.28 SD = .826), indicating improvement in readiness to implement supportive care screening. The number of participants using the tool increased from 57.57% pre-program to 77.78% 3 months post-program. Overall, participants agreed that screening elicited more patient information (post M = 3.82 SD = 1.006; 3 months M = 3.83 SD = .786) and would assist in addressing patients' supportive care needs (post M = 4.00 SD.926; 3 months M = 3.94 SD = .998). It was unclear whether they had made more appropriate referrals as a result of their participation in the program (post M = 3.29 SD = 1.102; 3 months M = 3.11 SD = .963). The majority of participants agreed that the web-based program provided the required information to implement supportive care screening (post M = 3.83 SD = 1.032; 3 months M = 3.61 SD = .702), and that the quiz helped their learning (post M = 3.68 SD = 1.041; 3 months M = 3.65 SD = .702). This pilot indicates that provision of a short concise web-based program may improve clinicians' confidence and skills to implement supportive care
Paterson, Carly; Lengacher, Cecile A.; Donovan, Kristine A.; Kip, Kevin E.; Tofthagen, Cindy S.
Background Body image is a complex issue with the potential to impact many aspects of cancer survivorship, particularly for the younger breast cancer survivor. Objective The purpose of this review is to synthesize the current state of the science for body image in younger women with breast cancer. Intervention/Methods Combinations of the terms “body image,” “sexuality intervention,” “women,” “younger women,” and “breast cancer” were searched in the PubMed, PsycInfo, CINAHL, Web of Knowledge and Science Direct databases through January 2014. Inclusion criteria for this review were: 1) original research; 2) published in English from the year 2000 forward; 3) measuring body image as an outcome variable; and 4) results included reporting of age-related outcomes. Results Thirty-six articles met the inclusion criteria. The majority of studies were cross-sectional, with extensive variation in body image assessment tools. Age and treatment type had a significant impact on body image, and poorer body image was related to physical and psychological distress, sex and intimacy, and the partnered relationship among younger women. Only one intervention study found a significant improvement in body image post-intervention. Conclusions Findings suggest body image is a complex post-treatment concern for breast cancer survivors, particularly younger women. The findings of this review are limited by the high level of variation in the methods for assessing body image. Implications for Practice Further research of interventions to address body image concerns following treatment for breast cancer is warranted. Improvement of body image may improve the quality of life of younger breast cancer survivors. PMID:25881807
Austin T Humphries
Full Text Available Interactions between predators and their prey are influenced by the habitat they occupy. Using created oyster (Crassostrea virginica reef mesocosms, we conducted a series of laboratory experiments that created structure and manipulated complexity as well as prey density and "predator-free space" to examine the relationship between structural complexity and prey survivorship. Specifically, volume and spatial arrangement of oysters as well as prey density were manipulated, and the survivorship of prey (grass shrimp, Palaemonetes pugio in the presence of a predator (wild red drum, Sciaenops ocellatus was quantified. We found that the presence of structure increased prey survivorship, and that increasing complexity of this structure further increased survivorship, but only to a point. This agrees with the theory that structural complexity may influence predator-prey dynamics, but that a threshold exists with diminishing returns. These results held true even when prey density was scaled to structural complexity, or the amount of "predator-free space" was manipulated within our created reef mesocosms. The presence of structure and its complexity (oyster shell volume were more important in facilitating prey survivorship than perceived refugia or density-dependent prey effects. A more accurate indicator of refugia might require "predator-free space" measures that also account for the available area within the structure itself (i.e., volume and not just on the surface of a structure. Creating experiments that better mimic natural conditions and test a wider range of "predator-free space" are suggested to better understand the role of structural complexity in oyster reefs and other complex habitats.
Bommireddy, P L; Leonard, B R
A series of tests quantified bollworm, Helicoverpa zea (Boddie), and tobacco budworm, Heliothis virescens (F.), larval survival on plant structures of a nontransgenic cotton (Gossypium hirsutum L.), 'Coker 312', and two transgenic cottons expressing Vip3A protein or both Vip3A + CrylAb proteins (VipCot). Vegetative and reproductive structures including terminal leaves, flower bud (square) bracts, whole debracted squares, flower petals, flower anthers, and intact capsules (bolls) were harvested from plants in field plots. Each structure was infested with 2-d-old larvae from one of the two heliothine species. Larvae were allowed to feed for 96 h on fresh tissue. Survivorship at 96 h after infestation was significantly lower on all structures of Vip3A and VipCot cotton lines compared with similar structures of Coker 312. VipCot plant structures generally resulted in lower larval survivorship compared with similar structures of the Vip3A cotton line. H. zea survivorship ranged from 4 to 28% and from 1 to 18% on Vip3A and VipCot plant structures, respectively. H. virescens survivorship ranged from 10 to 43% and from 2 to 12% on Vip3A and VipCot plant structures, respectively. H. virescens survivorship was higher on VIP3A plant structures compared with that for H. zea on similar structures. These differences between species were not observed on plants from the cotton line expressing VipCot proteins. The results for these plant structures demonstrate that the combination of proteins expressed in VipCot cotton lines are more effective than Vip3A cotton lines against this heliothine complex.
Humphries, Austin T.; La Peyre, Megan K.; Decossas, Gary A.
Interactions between predators and their prey are influenced by the habitat they occupy. Using created oyster (Crassostrea virginica) reef mesocosms, we conducted a series of laboratory experiments that created structure and manipulated complexity as well as prey density and “predator-free space” to examine the relationship between structural complexity and prey survivorship. Specifically, volume and spatial arrangement of oysters as well as prey density were manipulated, and the survivorship of prey (grass shrimp, Palaemonetes pugio) in the presence of a predator (wild red drum, Sciaenops ocellatus) was quantified. We found that the presence of structure increased prey survivorship, and that increasing complexity of this structure further increased survivorship, but only to a point. This agrees with the theory that structural complexity may influence predator-prey dynamics, but that a threshold exists with diminishing returns. These results held true even when prey density was scaled to structural complexity, or the amount of “predator-free space” was manipulated within our created reef mesocosms. The presence of structure and its complexity (oyster shell volume) were more important in facilitating prey survivorship than perceived refugia or density-dependent prey effects. A more accurate indicator of refugia might require “predator-free space” measures that also account for the available area within the structure itself (i.e., volume) and not just on the surface of a structure. Creating experiments that better mimic natural conditions and test a wider range of “predator-free space” are suggested to better understand the role of structural complexity in oyster reefs and other complex habitats.
Hanley, Mick E.; Fenner, Michael
The role of heat shock in the induction of seed germination for numerous Mediterranean fire-following plant species is well documented. However, the influence of pre-germination heating of seeds upon seedling survivorship and onward growth has not been studied. The aim of the experiments described here was to investigate how a range of heat treatments affects seedling survivorship and onward growth for six common fire-following Mediterranean plant species ( Anthyllis vulneraria, Cistus creticus, C. salvifolius, Hippocrepis unisiliquosa, Pinus brutia and P. halepensis). In the first experiment, seeds of five species were heated to temperatures ranging between 80°C and 120°C (at 10°C intervals) for 10 min and subsequent seedling growth monitored over 8 weeks. Survivorship for two pine species ( Pinus halepensis and Pinus brutia) was reduced after seeds were heated above 90°C. Onward growth for Pinus halepensis and the legume, Anthyllis vulneraria, was negatively affected by increasing pre-germination temperature. Survivorship and growth for both Cistus species was unaffected by heating seeds up to 110°C. The second experiment examined more closely seedling performance of Hippocrepis unisiliquosa seedlings when seeds were heated to temperatures ranging between 50°C and 90°C (at 10°C intervals) for 5, 10, 15 and 20 mins. Increasing pre-germination temperature and the length of time seeds were exposed to heating significantly reduced seedling growth rates in this species. The effect of fire on seedling emergence, growth and survivorship in the field is discussed with reference to the adaptation of the six species to post-fire regeneration and the patterns of seedling regeneration observed in the field.
Weaver, Anne M; McCann, Susan E; Nie, Jing; Edge, Stephen B; Nochajski, Thomas H; Russell, Marcia; Trevisan, Maurizio; Freudenheim, Jo L
Alcohol intake is a risk factor for breast cancer, but the association between alcohol and mortality among breast cancer survivors is poorly understood. We examined the association between alcohol intake from all sources, assessed by cognitive lifetime drinking history, and all-cause and breast cancer mortality among women with breast cancer (N = 1,097) who participated in a population-based case-control study. Vital status was ascertained through 2006 using the National Death Index. Using Cox proportional hazards models, we computed hazard ratios for all-cause and breast cancer mortality in association with alcohol intake. We examined lifetime volume and intensity (drinks per drinking day) of alcohol consumption as well as drinking status during various life periods. Analyses were stratified by menopausal status. After adjustment for total intake, postmenopausal women with consumption of four or more drinks per drinking day over their lifetimes were nearly three times more likely to die from any cause compared to abstainers (HR 2.94, 95 % CI 1.31, 6.62). There was a similar but non-significant association with breast cancer mortality (HR 2.68, 95 % CI 0.94, 7.67). Postmenopausal women who drank one drink or fewer per drinking day between menarche and first birth had a significantly decreased hazard of all-cause (HR 0.54, 95 % CI 0.31, 0.95) and breast cancer mortality (HR 0.27, 95 % CI 0.09, 0.77). Premenopausal breast cancer survival was not associated with drinking intensity. We observed no associations between drinking status or total volume of alcohol intake and breast cancer or all-cause mortality. High-intensity alcohol consumption may be associated with decreased survival in postmenopausal women with breast cancer. Low-intensity alcohol consumption between menarche and first birth may be inversely associated with all-cause and breast cancer mortality; this period may be critical for development of and survival from breast cancer. Intensity of alcohol intake
Riesgo, Aldo M; Hochfelder, Jason P; Adler, Edward M; Slover, James D; Specht, Lawrence M; Iorio, Richard
We retrospectively reviewed 161 revision THAs with diaphyseal fitting, mid-modular femoral components performed by ten surgeons at two academic medical centers. The average follow-up was 6.1 years. At final follow-up, 4 patients required re-revision for failure of the femoral component; 3 (2%) for aseptic loosening and 1 for mechanical failure of stem in setting of periprosthetic fracture. There were a total of 24 (14.9%) revisions for any reason, with the most common reason being septic failure (10 of 24). To our knowledge, this is the largest reported series of mid-term survivorship and complications of revision THA with mid-modular femoral components. Our results show that these stems have a low rate of aseptic loosening, subsidence, and mechanical failure.
van den Berg, Sanne W; van Amstel, Floortje K Ploos; Ottevanger, Petronella B; Gielissen, Marieke F M; Prins, Judith B
New models of cancer care and survivorship ask for empowered patients. But how do we measure that patients can derive strength from themselves (intrapersonal) and their perceived social support (interpersonal)? The 40-item Cancer Empowerment Questionnaire (CEQ) measures psychological empowerment as an individual outcome measure. The CEQ was validated in 140 nonmetastatic female breast cancer survivors (mean 5.5 years postsurgery). Principal component analysis elicited four factors representing intrapersonal (personal strength) and interpersonal (social support, community, health care) aspects of empowerment. The CEQ provides a reliable (Cronbach's α=0.73-0.94) and valid first attempt to operationalize psychological empowerment in cancer care.
Stapleton, Jerod L; Tatum, Kristina L; Devine, Katie A; Stephens, Sue; Masterson, Margaret; Baig, Amna; Hudson, Shawna V; Coups, Elliot J
The risk of developing skin cancer is elevated among childhood cancer survivors (CCS), particularly among those treated with radiation. This survey study examined the skin cancer surveillance behaviors of 94 CCS. Approximately 48% of CCS had ever conducted skin self-examination (SSE) and 31% had ever received a physician skin examination. Rates of physician skin examination were 2.5 times higher among CCS treated with radiation compared to those without radiation. However, rates of SSEs did not differ based on treatment history. These findings highlight the need to promote skin cancer surveillance as an important aspect of CCS survivorship care.
Fieke Z. Bruggeman Everts
Conclusion: These findings suggest that individual eMBCT may be effective in reducing fatigue in cancer survivors. A randomized controlled study with a large sample and longer follow up is needed to demonstrate the effectiveness of eMBCT for CRF.
Cohen, A.R.; Vitányi, P.M.B.
Normalized web distance (NWD) is a similarity or normalized semantic distance based on the World Wide Web or any other large electronic database, for instance Wikipedia, and a search engine that returns reliable aggregate page counts. For sets of search terms the NWD gives a similarity on a scale fr
Schmidt, M.E.; Chang-Claude, J.; Vrieling, A.; Heinz, J.; Flesch-Janys, D.; Steindorf, K.
INTRODUCTION: Fatigue is a frequent problem during and after cancer treatment. We investigated different courses of fatigue from pre-diagnosis, through therapy, to long-term survivorship and evaluated potential implications on long-term quality of life (QoL). METHODS: Breast cancer patients diagnose
Gorin, Sherri Sheinfeld; McAuliffe, Patrick
Purpose: The aims of this paper are to: briefly review the long-term or late effects of cancer diagnosis and treatment on children and youth; examine the implications of these effects on the educational needs of the child or youth; explore the implications of childhood cancer survivorship on the school, particularly for female students. Over the…
Full Text Available On World Wide Web various kind of content are generated in huge amount, so to give relevant result to user web recommendation become important part of web application. On web different kind of web recommendation are made available to user every day that includes Image, Video, Audio, query suggestion and web page. In this paper we are aiming at providing framework for web page recommendation. 1 First we describe the basics of web mining, types of web mining. 2 Details of each web mining technique.3We propose the architecture for the personalized web page recommendation.
Semantic Web Services for Web Databases introduces an end-to-end framework for querying Web databases using novel Web service querying techniques. This includes a detailed framework for the query infrastructure for Web databases and services. Case studies are covered in the last section of this book. Semantic Web Services For Web Databases is designed for practitioners and researchers focused on service-oriented computing and Web databases.
Full Text Available The information on the web is growing dramatically. The users has to spend lots of time on the web finding the information they are interested in. Today, he traditional search engines do not give users enough personalized help but provide the user with lots of irrelevant information. In this paper, we present a personalize Web searchsystem, which can helps users to get the relevant web pages based on their selection from the domain list. Thus, users can obtain a set of interested domains and the web pages from the system. The system is based on features extracted from hyperlinks, such as anchor terms or URL tokens. Our methodology uses an innovative weighted URL Rank algorithm based on user interested domains and user query.
Høybye, Mette Terp; Olsen, Pia Riis; Hansson, Helena Eva
Bringing virtual environments into cancer support may offer a particular potential to engage patients and increase adherence to treatment. Developing and pilot-testing an online real-time multi-user three-dimensional platform, this study tested the use of an early prototype of the platform among...
Delin, Kevin A. (Inventor); Jackson, Shannon P. (Inventor)
A Sensor Web formed of a number of different sensor pods. Each of the sensor pods include a clock which is synchronized with a master clock so that all of the sensor pods in the Web have a synchronized clock. The synchronization is carried out by first using a coarse synchronization which takes less power, and subsequently carrying out a fine synchronization to make a fine sync of all the pods on the Web. After the synchronization, the pods ping their neighbors to determine which pods are listening and responded, and then only listen during time slots corresponding to those pods which respond.
Aliaga-Rossel, Enzo; Manuel Fragoso, Jos
Animal-plant interactions in Neotropical forests are complex processes. Within these processes, mid- to large-sized mammals consume fruits and seeds from several species; however, because of their size these mammals are overhunted, resulting in defaunated forests. Our objective was to evaluate and compare seed removal and survivorship in a forest with no hunting, a forest with moderate or reduced hunting, and a forest with higher hunting pressure. We examined the interaction between Astrocaryum gratum and white lipped peccary (Tayassu pecari) to tease apart the defaunation process. To isolate and evaluate mammal seed removal rates and to identify the causes of mortality on Agratum, under the three different hunting pressures forests, we used exclosures in each one. In four different forest-patches for each forest, we positioned a block-treatment consisting of three exclosures (total exclusion, peccary exclusion, and control), randomly distributed 5m apart and the block-treatments spaced 50-75 m apart from one another. We established 15 treatments in total for each patch (5 blocks per patch). There were 20 blocks within each forest type. For total exclusion, all vertebrates were excluded using galvanized wire mesh exclosures. The second, the peccary exclusion, was designed to stop peccaries from entering treatment units, providing access only to small vertebrates; larger mammals were able to access the treatment unit by reaching over the sides and the open top; finally, the Control allowed full access for all mammals. Fresh A. gratum fruits were collected from the forest floor under different adult trees throughout the study area. In each exclosure treatment, twenty Agratum seeds were placed, and their removal was recorded. In total, 3 600 seeds were analyzed. Seed survival was lower in unhunted forest compared to areas with moderate hunting and forest with a higher hunt pressure, supporting the hypothesis of the importance of mammals in seed removal. From the
Love, Milton S.; Sandhu, Meenu; Stein, Jeffrey; Herbinson, Kevin T.; Moore, Robert H; Mullin, Michael; Stephens, John S.
This study examined the efficiency of fish diversion and survivorship of diverted fishes in the San Onofre Nuclear Generating Station Fish Return System in 1984 and 1985. Generally, fishes were diverted back to the ocean with high frequency, particularly in 1984. Most species were diverted at rates of 80% or more. Over 90% of the most abundant species, Engraulis mordax, were diverted. The system worked particularly well for strong-swimming forms such as Paralobrax clothratus, Atherinopsis cal...
Alekseev, Victor; Alekseev, Victor; Novikova, Nataliya; Sychev, Vladimir; Levinskikh, Margarita; Deshevaya, Elena; Brancelj, Anton; Malyavin, Stanislav
Dormancy protects animals and plants in harsh environmental conditions within a special resting phases of life cycle lasting from months up to hundred years. This phenomenon is perspective for space researches on interplanetary quarantine within space missions. Direct experiments in open space supported in principle the fact of survivorship of bacteria and fungi spores in open space during long time experiments (Novikova et al. 2007). The rate of survivorship in long-term mission was low but enough to conclude that biological invasion to Mars is a real danger. The possibility for resting stages to survive under UV treatment in vacuum without some protection was not clear. To test it dormant stages (spores) of primitive fungi Aspergillus versicolor, Aspergillus sydowii, Penicillium expansum, and Penicillium aurantiogriseum derived from ISS environment were used in the land EXPOSE imitation of outside space station UV and vacuum conditions. Survivorship in resting eggs of some crustaceans with dried (cladoceran Daphnia magna, fair-shrimp Streptocephalus torvicornis and ostracode Eucypris ornate from hemi desert Caspian area) and wet diapause state (copepod Mixodiaptomus tatricus from the Tatra mountains, altitude 1510 m) was tested also. The total UV dose of 9,1x10 to the 4th KJ/m2 during this imitation was accomplished with a SOL 2000 sun simulator lamp. The final vacuum value achieved during EST was 10 to the minus 6 Pa. Temperature during the experiment fluctuated in the range 19-25 o C. Micro fungi showed a high level of survivorship in samples treated with UV samples varied from 95 till 100 Supported by RFBR grant 07-04-00006.
Timmerman, Josien G.; Tönis, Thijs M.; Dekker-van Weering, Marit G.H.; Stuiver, Martijn M.; Wouters, Michel W.J.M.; Harten, van Wim H.; Hermens, Hermie J.; Vollenbroek-Hutten, Miriam M.R.
Background: Lung cancer (LC) patients experience high symptom burden and significant decline of physical fitness and quality of life following lung resection. Good quality of survivorship care post-surgery is essential to optimize recovery and prevent unscheduled healthcare use. The use of Informati
Full Text Available Daniel J Cher,1 W Carlton Reckling,2 Robyn A Capobianco1 1Department of Clinical Affairs, SI-BONE, Inc., 2Department of Medical Affairs, SI-BONE, Inc., San Jose, CA, USA Introduction: Surgical revision rate is a key outcome with all permanent implants. The iFuse Implant System® is a permanent implant used to perform minimally invasive sacroiliac joint fusion. The purpose of this study is to determine the surgical revision rate after sacroiliac joint fusion surgery with this system. Methods: Using two internal sources of information, revision surgeries were identified and linked to index surgeries. The likelihood of revision surgery was calculated using the Kaplan–Meier life table approach. Predictors of revision were explored. Results: Four-year survivorship free from implant revision was 96.46%. Revision rate did not differ by sex and was lower for age >65. In all, 24% of revisions occurred within the first 30 days after surgery; 63.5% occurred within year 1. Implant survivorship has improved annually since the device was introduced in 2009. Conclusion: The survivorship rate with this implant is high and improving; the rate is somewhat higher than total hip replacement but lower than that of lumbar spine procedures. Keywords: safety, sacroiliac joint fusion, iFuse Implant System, revision
Badr, H; Lipnick, D; Diefenbach, M A; Posner, M; Kotz, T; Miles, B; Genden, E
Oral cancer (OC) survivors experience debilitating side effects that affect their quality of life (QOL) and that of their caregivers. This study aimed to develop and evaluate a dyadic, web-based intervention to improve survivor self-management and survivor/caregiver QOL. A qualitative needs assessment (semi-structured interviews) with 13 OC survivors and 12 caregivers was conducted to discern information and support needs as well as preferences regarding website features and tools. Results using Grounded Theory analysis showed that OC survivors and caregivers: (1) want and need practical advice about managing side effects; (2) want to reach out to other survivors/caregivers for information and support; and (3) have both overlapping and unique needs and preferences regarding website features. Usability testing (N = 6 survivors; 5 caregivers) uncovered problems with the intuitiveness, navigation and design of the website that were subsequently addressed. Users rated the website favourably on the dimensions of attractiveness, controllability, efficiency, intuitiveness and learnability, and gave it a total usability score of 80/100. Overall, this study demonstrates that OC survivors and caregivers are interested in using an online programme to improve QOL, and that providing tailored website content and features based on the person's role as survivor or caregiver is important in this population.
Tao, Meng-Hua; Dai, Qi; Millen, Amy E; Nie, Jing; Edge, Stephen B; Trevisan, Maurizio; Shields, Peter G; Freudenheim, Jo L
Magnesium (Mg) and calcium (Ca) antagonizes each other in (re) absorption, cell cycle regulation, inflammation, and many other physiologic activities. However, few studies have investigated the association between magnesium and calcium intakes and breast cancer survival, and the interaction between calcium and magnesium intake. In a cohort of 1,170 women with primary, incident, and histologically confirmed breast cancer from Western New York State, we examined the relationship between intakes of these two minerals and survival. Cox regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI). Mean follow-up time was 87.4 months after breast cancer diagnosis; there were 170 deaths identified. After adjustment for known prognostic factors, and intakes of energy, total vitamin D and total calcium, higher dietary intake of magnesium was inversely associated with risk of all-cause mortality (HR = 0.50, 95% CI, 0.28-0.90 for highest vs. lowest tertile; p trend = 0.02). Likewise, a marginal association was found for total Magnesium intake from foods and supplements combined (HR = 0.58, 95% CI, 0.31-1.08; p trend = 0.09). The inverse association of higher total magnesium intake with all-cause mortality was primarily presented among postmenopausal women and was stronger among women who had a high Ca:Mg intake ratio (>2.59). There were no clear associations for prognosis with intake of calcium. We found that magnesium intake alone may improve overall survival following breast cancer, and the association may be stronger among those with high Ca:Mg intake ratio.
David A. Gibbs
Full Text Available Species-specific enemies may promote prey coexistence through negative distance- and density-dependent survival of juveniles near conspecific adults. We tested this mechanism by transplanting juvenile-sized fragments of the brooding corals Pocillopora damicornis and Seriatopora hystrix 3, 12, 24 and 182 cm up- and down-current of conspecific adults and monitoring their survival and condition over time. We also characterized the spatial distribution of P. damicornis and S. hystrix within replicate plots on three Fijian reef flats and measured the distribution of small colonies within 2 m of larger colonies of each species. Juvenile-sized transplants exhibited no differences in survivorship as a function of distance from adult P. damicornis or S. hystrix. Additionally, both P. damicornis and S. hystrix were aggregated rather than overdispersed on natural reefs. However, a pattern of juveniles being aggregated near adults while larger (and probably older colonies were not suggests that greater mortality near large adults could occur over longer periods of time or that size-dependent mortality was occurring. While we found minimal evidence of greater mortality of small colonies near adult conspecifics in our transplant experiments, we did document hot-spots of species-specific corallivory. We detected spatially localized and temporally persistent predation on P. damicornis by the territorial triggerfish Balistapus undulatus. This patchy predation did not occur for S. hystrix. This variable selective regime in an otherwise more uniform environment could be one mechanism maintaining diversity of corals on Indo-Pacific reefs.
Wolpin, S E; Halpenny, B; Whitman, G; McReynolds, J; Stewart, M; Lober, W B; Berry, D L
The feasibility and acceptability of computerized screening and patient-reported outcome measures have been demonstrated in the literature. However, patient-centered management of health information entails two challenges: gathering and presenting data using "patient-tailored" methods and supporting "patient-control" of health information. The design and development of many symptom and quality-of-life information systems have not included opportunities for systematically collecting and analyzing user input. As part of a larger clinical trial, the Electronic Self-Report Assessment for Cancer-II project, participatory design approaches were used to build and test new features and interfaces for patient/caregiver users. The research questions centered on patient/caregiver preferences with regard to the following: (a) content, (b) user interface needs, (c) patient-oriented summary, and (d) patient-controlled sharing of information with family, caregivers, and clinicians. Mixed methods were used with an emphasis on qualitative approaches; focus groups and individual usability tests were the primary research methods. Focus group data were content analyzed, while individual usability sessions were assessed with both qualitative and quantitative methods. We identified 12 key patient/caregiver preferences through focus groups with 6 participants. We implemented seven of these preferences during the iterative design process. We deferred development for some of the preferences due to resource constraints. During individual usability testing (n = 8), we were able to identify 65 usability issues ranging from minor user confusion to critical errors that blocked task completion. The participatory development model that we used led to features and design revisions that were patient centered. We are currently evaluating new approaches for the application interface and for future research pathways. We encourage other researchers to adopt user-centered design approaches when building
The concept of "cancer survivorship" has received considerable attention over the past three years as increasing numbers of people live with and beyond cancer. Previously, attention may have focused more on treatments for cancer and the likelihood of their success. In recent years, interest has moved to the after-effects of treatment, and how people can return to their lives while recovering. This article discusses the various ways in which cancer and its treatment may affect survivors, and how nurses, in both hospital and the community, can help them to adjust and recover.
Tai Chong Toh
Full Text Available Size-dependent mortality influences the recolonization success of juvenile corals transplanted for reef restoration and assisting juvenile corals attain a refuge size would thus improve post-transplantation survivorship. To explore colony size augmentation strategies, recruits of the scleractinian coral Pocillopora damicornis were fed with live Artemia salina nauplii twice a week for 24 weeks in an ex situ coral nursery. Fed recruits grew significantly faster than unfed ones, with corals in the 3600, 1800, 600 and 0 (control nauplii/L groups exhibiting volumetric growth rates of 10.65 ± 1.46, 4.69 ± 0.9, 3.64 ± 0.55 and 1.18 ± 0.37 mm3/week, respectively. Corals supplied with the highest density of nauplii increased their ecological volume by more than 74 times their initial size, achieving a mean final volume of 248.38 ± 33.44 mm3. The benefits of feeding were apparent even after transplantation to the reef. The corals in the 3600, 1800, 600 and 0 nauplii/L groups grew to final sizes of 4875 ± 260 mm3, 2036 ± 627 mm3, 1066 ± 70 mm3 and 512 ± 116 mm3, respectively. The fed corals had significantly higher survival rates than the unfed ones after transplantation (63%, 59%, 56% and 38% for the 3600, 1800, 600 and 0 nauplii/L treatments respectively. Additionally, cost-effectiveness analysis revealed that the costs per unit volumetric growth were drastically reduced with increasing feed densities. Corals fed with the highest density of nauplii were the most cost-effective (US$0.02/mm3, and were more than 12 times cheaper than the controls. This study demonstrated that nutrition enhancement can augment coral growth and post-transplantation survival, and is a biologically and economically viable option that can be used to supplement existing coral mariculture procedures and enhance reef restoration outcomes.
García Populin, Iván
Trabajo final de carrera desarrollado en .NET. Presenta un gestor de contenidos web para generar una web publicitaria. Treball final de carrera desenvolupat en .NET. Presenta un gestor de continguts web per generar una web publicitària.
Mark C Ladd
Full Text Available AbstractCoral restoration is gaining traction as a viable strategy to help restore degraded reefs. While the nascent field of coral restoration has rapidly progressed in the past decade, significant knowledge gaps remain regarding the drivers of restoration success that may impede our ability to effectively restore coral reef communities. Here, we conducted a field experiment to investigate the influence of coral density on the growth, habitat production, and survival of corals outplanted for restoration. We used nursery-raised colonies of Acropora cervicornis to experimentally establish populations of corals with either 3, 6, 12, or 24 corals within 4m2 plots, generating a gradient of coral densities ranging from 0.75 corals m-2 to 12 corals m-2. After 13 months we found that density had a significant effect on the growth, habitat production, and survivorship of restored corals. We found that coral survivorship increased as colony density decreased. Importantly, the signal of density dependent effects was context dependent. Our data suggest that positive density dependent effects influenced habitat production at densities of 3 corals m-2, but further increases in density resulted in negative density dependent effects with decreasing growth and survivorship of corals. These findings highlight the importance of density dependence for coral restoration planning and demonstrate the need to evaluate the influence of density for other coral species used for restoration. Further work focused on the mechanisms causing density dependence such as increased herbivory, rapid disease transmission, or altered predation rates are important next steps to advance our ability to effectively restore coral reefs.
Heins, M.J.; Korevaar, J.C.; Hopman, E.J.C.; Donker, G.A.; Schellevis, F.G.
Background: The number of cancer survivors steadily increases. The long‐term planning of care in the survivorship phase necessitates a different approach than the short‐term planning in the treatment phase. Principles of disease management programs could provide an interesting perspective to improve
Alekseev, Victor; Novikova, Nataliya; Levinskikh, Margarita; Sychev, Vladimir; Yusoff, Fatimah; Azuraidi, Osman
Dormancy protects animals and plants in harsh environmental conditions from months up to hundred years. This phenomenon is perspective for space researches especially for interplanetary missions. Direct experiments in open space BYORYSK supported in principle the fact of survivorship of bacteria, fungi spores, seed of plants and crustacean dormant cysts. Even though the rate of survivorship in long-term treatments was low but good enough to conclude that biological invasion even to Mars is a real danger. As soon as the BYORYSK lunch was made of metal the possibility for resting stages to survive under UV treatment in vacuum without some protection was not clear. To test it an ESA and RSA equipment titled EXPOSE-R was applied. The EXPOSE-R facility was an external facility attached to the outside of the Zvezda Service Module in ISS in the end of November 2008. It had glace windows transparent for UV-radiation and possibility to measure temperature, space- and UV-radiation. Among a number of experiments requiring exposure to the open space environment it had a biological launch containing resting stages of terrestrial and aquatic organisms. These stages included dried ephippia of cladoceran Daphnia magna differentiated on size, dormant eggs of ostracode Eucypris ornate, cysts of fair-shrimp Streptocephalus torvicornis ( all from hemi desert Caspian area) and Artemis salina from salt lake Crimean populations. All dormant stages were kept in transparent to UV plastic bags placed in three layers. After about two years of exposing in open space dormant stages of 3 species A. salina, D. magna, S. torvicornis successfully survived at different scales but in second and third layers only . The highest level of survivorship was found in A. salina cysts. In preliminary land experiments that imitated land EXPOSE imitation of outside space station UV and vacuum conditions survivorship in resting eggs of D .magna, S. torvicornis and E. ornate was tested also. The total UV dose of
Green McDonald, Paige; O'Connell, Mary; Lutgendorf, Susan K
This article introduces the supplement Advances in Cancer and Brain, Behavior, and Immunity and outlines important discoveries, paradigm shifts, and methodological innovations that have emerged in the past decade to advance mechanistic and translational understanding of biobehavioral influences on tumor biology, cancer treatment-related sequelae, and cancer outcomes. We offer a heuristic framework for research on biobehavioral pathways in cancer. The shifting survivorship landscape is highlighted, and we propose that the changing demographics suggest prudent adoption of a life course perspective of cancer and cancer survivorship. We note opportunities for psychoneuroimmunology (PNI) research to ameliorate the long-term, unintended consequences of aggressive curative intent and call attention to the critical role of reciprocal translational pathways between animal and human studies. Lastly, we briefly summarize the articles included in this compilation and offer our perspectives on future research directions.
Hopley, Colin D J; Crossett, Lawrence S; Chen, Antonia F
A systematic search identified 29 papers reporting survivorship and clinical and function Knee Society Scores (KSS) of 6437 total knee replacements using the Low Contact Stress (LCS) Rotating Platform (RP) mobile bearing knee. Low Contact Stress RP survivorship and KSS outcomes were compared with non-LCS knees in the Swedish knee registry at comparable time periods and in 2 independent systematic reviews of knee arthroplasty outcomes. There is a substantial body of mainly observational evidence supporting the LCS RP knee. Knee Society Score outcomes were comparable for LCS RP and non-LCS RP knees at up to 15 years of follow-up, with mean clinical and function scores ranging from 72 to 96 and 58 to 90, respectively. Survivorship of LCS RP knees up to 14 years was higher than that for all knees in the Swedish Knee Registry.
Quinn, Gwendolyn P; Sanchez, Julian A; Sutton, Steven K; Vadaparampil, Susan T; Nguyen, Giang T; Green, B Lee; Kanetsky, Peter A; Schabath, Matthew B
This article provides an overview of the current literature on seven cancer sites that may disproportionately affect lesbian, gay, bisexual, transgender/transsexual, and queer/questioning (LGBTQ) populations. For each cancer site, the authors present and discuss the descriptive statistics, primary prevention, secondary prevention and preclinical disease, tertiary prevention and late-stage disease, and clinical implications. Finally, an overview of psychosocial factors related to cancer survivorship is offered as well as strategies for improving access to care.
Syme, Maggie L.; Delaney, Eileen; Moye, Jennifer; Gosian, Jeffrey; Wachen, Jennifer Schuster
Little is known about the sexual well-being of male Veteran cancer survivors, or the relationship of sexual concerns to psychosocial adaptation postcancer. This study examined the association between sexual self-esteem and psychosocial concerns in male Veteran cancer survivors. Forty-one male survivors were recruited from a Veterans Affairs (VA) hospital to participate in a pilot study addressing cancer survivorship care for Veterans. Sixty- to 90-minute interviews were conducted, assessing s...
... are available to help. HELPFUL WEB SITES ON LUNG CANCER American Lung Association www.lung.org Lungcancer.org www.lungcancer.org Lung Cancer Alliance www.lungcanceralliance.org Lung Cancer Online www. ...
This study investigated the influence of cannibalism on egg and larval mortality, and on the deposition strategies of adults, in a tropical anuran breeding in very small leaf axil pools. Patterns of egg and tadpole deposition and mortality in the Amazonian poison frog, Dendrobates ventrimaculatus, were monitored in rainforest near Pompeya in Sucumbios Province, Ecuador. Oviposition and tadpole deposition typically ocurred in leaf axils of Heliconia plants. Pools typically received more than one oviposition. Egg survivorship was low, and significantly lower when eggs were deposited in pools with large tadpoles, indicating that cannibalism is an important source of mortality. Tadpole survivorship was also associated with the presence of other tadpoles: most pools ended with only one surviving tadpole, regardless of the number of tadpoles deposited in the pool. Egg deposition was signifcantly less likely for pools that had a tadpole in them, suggesting that adults can detect the presence of tadpoles and avoid ovipositing in pools that contain them. This hypothesis was tested with a series of pool choice experiments, which revealed that D. ventrimaculatus avoid placing either eggs or tadpoles into a pool which contains a large tadpole. Several hypotheses which could explain multiple deposition in this species are discussed.
The second, called the deep web , consists of roughly 96% or the rest of the web . The deep web consists of protected sites that re- quire users to...financial records, research & development), and personal data (medical records or legal documents). These are all deep web . Standard search engines...don’t have access to these sites and therefore cannot search them. The last web is the dark web , a part of the deep web . It requires specific software
Montgomery, Guy H; Schnur, Julie B; Kravits, Kate
Answer questions and earn CME/CNE Hypnosis has been used to provide psychological and physical comfort to individuals diagnosed with cancer for nearly 200 years. The goals of this review are: 1) to describe hypnosis and its components and to dispel misconceptions; 2) to provide an overview of hypnosis as a cancer prevention and control technique (covering its use in weight management, smoking cessation, as an adjunct to diagnostic and treatment procedures, survivorship, and metastatic disease); and 3) to discuss future research directions. Overall, the literature supports the benefits of hypnosis for improving quality of life during the course of cancer and its treatment. However, a great deal more work needs to be done to explore the use of hypnosis in survivorship, to understand the mediators and moderators of hypnosis interventions, and to develop effective dissemination strategies.
Full Text Available The semantic Web is a technology at the service of knowledge which is aimed at accessibility and the sharing of content; facilitating interoperability between different systems and as such is one of the nine key technological pillars of TIC (technologies for information and communication within the third theme, programme specific cooperation of the seventh programme framework for research and development (7°PQRS, 2007-2013. As a system it seeks to overcome overload or excess of irrelevant information in Internet, in order to facilitate specific or pertinent research. It is an extension of the existing Web in which the aim is for cooperation between and the computer and people (the dream of Sir Tim Berners –Lee where machines can give more support to people when integrating and elaborating data in order to obtain inferences and a global sharing of data. It is a technology that is able to favour the development of a “data web” in other words the creation of a space in both sets of interconnected and shared data (Linked Data which allows users to link different types of data coming from different sources. It is a technology that will have great effect on everyday life since it will permit the planning of “intelligent applications” in various sectors such as education and training, research, the business world, public information, tourism, health, and e-government. It is an innovative technology that activates a social transformation (socio-semantic Web on a world level since it redefines the cognitive universe of users and enables the sharing not only of information but of significance (collective and connected intelligence.
Schover, Leslie R; Yuan, Ying; Fellman, Bryan M; Odensky, Evan; Lewis, Pamela E; Martinetti, Paul
The recent NCCN Guidelines for Survivorship recommend systematic evaluation and multidisciplinary treatment of cancer-related sexual dysfunctions. However, most oncology professionals fail to routinely assess sexual problems and lack expertise to treat them. An Internet-based intervention was designed to educate female patients and their partners about cancer-related sexual problems, describe medical treatment options and how to find expert care, and provide self-help strategies. A randomized trial assessed efficacy of the intervention when used as self-help versus the same Web access and 3 supplemental counseling sessions. Survivors of localized breast or gynecologic cancers completed online questionnaires at baseline, posttreatment, and 3- and 6-month follow-up, including the Female Sexual Function Index (FSFI), the Menopausal Sexual Interest Questionnaire (MSIQ), the Brief Symptom Inventory-18 (BSI-18) to assess emotional distress, and the Quality of Life in Adult Cancer Survivors (QLACS) scale. Program evaluation ratings were completed posttreatment. Fifty-eight women completed baseline questionnaires (mean age, 53 ± 9 years). Drop-out rates were 22% during treatment and 34% at 6-month follow-up. Linear mixed models for each outcome across time showed improvement in total scores on the FSFI, MSIQ, and QLACS (P<.001) and BSI-18 (P=.001). The counseled group improved significantly more on sexuality measures, but changes in emotional distress and quality of life did not differ between groups. Program content and ease of use were rated positively. Research is needed on how best to integrate this intervention into routine clinical practice, and particularly how to improve uptake and adherence.
Otto, Sonja B; Berlow, Eric L; Rank, Nathan E; Smiley, John; Brose, Ulrich
Declining predator diversity may drastically affect the biomass and productivity of herbivores and plants. Understanding how changes in predator diversity can propagate through food webs to alter ecosystem function is one of the most challenging ecological research topics today. We studied the effects of predator removal in a simple natural food web in the Sierra Nevada mountains of California (USA). By excluding the predators of the third trophic level of a food web in a full-factorial design, we monitored cascading effects of varying predator diversity and composition on the herbivorous beetle Chrysomela aeneicollis and the willow Salix orestera, which compose the first and second trophic levels of the food web. Decreasing predator diversity increased herbivore biomass and survivorship, and consequently increased the amount of plant biomass consumed via a trophic cascade. Despite this simple linear mean effect of diversity on the strength of the trophic cascade, we found additivity, compensation, and interference in the effects of multiple predators on herbivores and plants. Herbivore survivorship and predator-prey interaction strengths varied with predator diversity, predator identity, and the identity of coexisting predators. Additive effects of predators on herbivores and plants may have been driven by temporal niche separation, whereas compensatory effects and interference occurred among predators with a similar phenology. Together, these results suggest that while the general trends of diversity effects may appear linear and additive, other information about species identity was required to predict the effects of removing individual predators. In a community that is not temporally well-mixed, predator traits such as phenology may help predict impacts of species loss on other species. Information about predator natural history and food web structure may help explain variation in predator diversity effects on trophic cascades and ecosystem function.
Casteleyn, Sven; Daniel, Florian; Dolog, Peter
Nowadays, Web applications are almost omnipresent. The Web has become a platform not only for information delivery, but also for eCommerce systems, social networks, mobile services, and distributed learning environments. Engineering Web applications involves many intrinsic challenges due...
Представлено краткое руководство по работе с сетевой сервисной программой EndNote Web на платформе Web of Knowledge издательства Thomson Reuters на русском языке. EndNote Web разработана для предоставления помощи исследователям и студентам в процессе написания научных публикаций. Позволяет создавать свои базы данных с собственными библиографическими списками для цитирования в научных работах....
US Agency for International Development — WebTA is a web-based time and attendance system that supports USAID payroll administration functions, and is designed to capture hours worked, leave used and...
Pollock, Jeffrey T
Semantic Web technology is already changing how we interact with data on the Web. By connecting random information on the Internet in new ways, Web 3.0, as it is sometimes called, represents an exciting online evolution. Whether you're a consumer doing research online, a business owner who wants to offer your customers the most useful Web site, or an IT manager eager to understand Semantic Web solutions, Semantic Web For Dummies is the place to start! It will help you:Know how the typical Internet user will recognize the effects of the Semantic WebExplore all the benefits the data Web offers t
Jay J Lunden
Full Text Available Changing global climate due to anthropogenic emissions of CO2 are driving rapid changes in the physical and chemical environment of the oceans via warming, deoxygenation, and acidification. These changes may threaten the persistence of species and populations across a range of latitudes and depths, including species that support diverse biological communities that in turn provide ecological stability and support commercial interests. Worldwide, but particularly in the North Atlantic and deep Gulf of Mexico, Lophelia pertusa forms expansive reefs that support biological communities whose diversity rivals that of tropical coral reefs. In this study, L. pertusa colonies were collected from the Viosca Knoll region in the Gulf of Mexico (390 to 450 m depth, genotyped using microsatellite markers, and exposed to a series of treatments testing survivorship responses to acidification, warming, and deoxygenation. All coral nubbins survived the acidification scenarios tested, between pH of 7.67 and 7.90 and aragonite saturation states of 0.92 and 1.47. However, calcification generally declined with respect to pH, though a disparate response was evident where select individuals net calcified and others exhibited net dissolution near a saturation state of 1. Warming and deoxygenation both had negative effects on survivorship, with up to 100% mortality observed at temperatures above 14ºC and oxygen concentrations of approximately 1.5 ml·l-1. These results suggest that, over the short-term, climate change and OA may negatively impact L. pertusa in the Gulf of Mexico, though the potential for acclimation and the effects of genetic background should be considered in future research.
Lunden, Jay J.; McNicholl, Conall G.; Sears, Christopher R.; Morrison, Cheryl; Cordes, Erik E.
Changing global climate due to anthropogenic emissions of CO2 are driving rapid changes in the physical and chemical environment of the oceans via warming, deoxygenation, and acidification. These changes may threaten the persistence of species and populations across a range of latitudes and depths, including species that support diverse biological communities that in turn provide ecological stability and support commercial interests. Worldwide, but particularly in the North Atlantic and deep Gulf of Mexico, Lophelia pertusa forms expansive reefs that support biological communities whose diversity rivals that of tropical coral reefs. In this study, L. pertusa colonies were collected from the Viosca Knoll region in the Gulf of Mexico (390 to 450 m depth), genotyped using microsatellite markers, and exposed to a series of treatments testing survivorship responses to acidification, warming, and deoxygenation. All coral nubbins survived the acidification scenarios tested, between pH of 7.67 and 7.90 and aragonite saturation states of 0.92 and 1.47. However, net calcification generally declined with respect to pH, though a disparate response was evident where select individuals net calcified and others exhibited net dissolution near a saturation state of 1. Warming and deoxygenation both had negative effects on survivorship, with up to 100% mortality observed at temperatures above 14°C and oxygen concentrations of approximately 1.5 ml· l−1. These results suggest that, over the short-term, climate change and OA may negatively impact L. pertusa in the Gulf of Mexico, though the potential for acclimation and the effects of genetic background should be considered in future research.
Lown, E Anne; Phillips, Farya; Schwartz, Lisa A; Rosenberg, Abby R; Jones, Barbara
Childhood cancer survivors (CCS) have a high risk of medical late effects following cancer therapy. Psychosocial late effects are less often recognized. Many CCS do not receive long-term follow-up (LTFU) care, and those who do are rarely screened for psychosocial late effects. An interdisciplinary team conducted a systematic review of qualitative and quantitative studies to assess social, educational, vocational, psychological, and behavioral outcomes along with factors related to receipt of LTFU care. We propose that psychosocial screening be considered a standard of care in long-term follow-up care and that education be provided to promote the use LTFU care starting early in the treatment trajectory.
With the rapid expansion and development of Internet and WWW (World Wide Web or Web), Web GIS (Web Geographical Information Systen) is becoming ever more popular and as a result numerous sites have added GIS capability on their Web sites. In this paper, the reasons behind developing a Web GIS instead of a “traditional” GIS are first outlined. Then the current status of Web GIS is reviewed, and their implementation methodologies are explored as well.The underlying technologies for developing Web GIS, such as Web Server, Web browser, CGI (Common Gateway Interface), Java, ActiveX, are discussed, and some typical implementation tools from both commercial and public domain are given as well. Finally, the future development direction of Web GIS is predicted.
Cancer begins in your cells, which are the building blocks of your body. Normally, your body forms ... be benign or malignant. Benign tumors aren't cancer while malignant ones are. Cells from malignant tumors ...
Jarir, Zahi; Erradi, Mahammed
The field of information extraction from the Web emerged with the growth of the Web and the multiplication of online data sources. This paper is an analysis of information extraction methods. It presents a service oriented approach for web information extraction considering both web data management and extraction services. Then we propose an SOA based architecture to enhance flexibility and on-the-fly modification of web extraction services. An implementation of the proposed architecture is proposed on the middleware level of Java Enterprise Edition (JEE) servers.
Kohle, Nadine; Drossaert, Constance H. C.; Schreurs, Karlein M. G.; Hagedoorn, Mariet; Verdonck-de Leeuw, Irma M.; Bohlmeijer, Ernst T.
Background: There is a growing recognition that cancer not only affects the lives of the patients, but also the lives of their partners. Partners of cancer patients are highly involved in the illness trajectory by providing informal care and they often experience distress. However, supporting interv
Práce se zabývá problematikou měření ukazatelů souvisejících s provozem webových stránek a aplikací a technologickými prostředky k tomu sloužícími ? Web Analytics (WA). Hlavním cílem práce je otestovat a porovnat vybrané zástupce těchto nástrojů a podrobit je srovnání podle objektivních kriterií, dále také kritické zhodnocení možností WA nástrojů obecně. V první části se práce zaměřuje na popis různých způsobů měření provozu na WWW a definuje související metriky. Poskytuje také přehled dostup...
Bethlehem, J.; Biffignandi, S.
Best practices to create and implementhighly effective web surveys Exclusively combining design and sampling issues, Handbook of Web Surveys presents a theoretical yet practical approach to creating and conducting web surveys. From the history of web surveys to various modes of data collection to ti
A step-by-step tutorial approach which will teach the readers what responsive web design is and how it is used in designing a responsive web page.If you are a web-designer looking to expand your skill set by learning the quickly growing industry standard of responsive web design, this book is ideal for you. Knowledge of CSS is assumed.
The WEB could be much more useful if the computers understood something of information on the Web pages. That explains the goal of the "semantic Web", a project in which takes part, amongst others, Tim Berners Lee, the inventor of the original WEB
Full Text Available Background: Health-related quality of life (HRQoL in cancer has been related to several protective and risk factors such as perceived social support (PSS and coping. However, their effects on HRQoL once patients are in survivorship have not been fully described in pediatric samples. Objective: To describe and explore the relationship between HRQoL in survivorship and some factors (PSS, coping present while active treatment. Methods: Cross-sectional study. Forty-one pediatric cancer survivors answered HRQoL measures referred to survivorship, as well as PSS and coping measures referred to treatment period. Results: The discriminant function obtained succeeds to correctly classify 78% of the sample. Survivors who showed high HRQoL were those who, in the hardest moment while hospitalization, perceived satisfactory emotional support (from nurses and did not deploy a wide range of active coping resources to cope with stressful events (only social action coping strategy showed a significant relationship with HRQoL. Conclusions and implications: Considering these outcomes, educational and counseling interventions to strengthen patients' social networks and supportive relationships are recommended, specially, among health providers (nurses. These results highlight the importance of not overlooking opportunities to address the emotional needs of patients while hospitalization, since a positive and endurable effect has been observed at survivorship.
Wang, Haibin; Tighiouart, Mourad; Huang, Shao-Chi; Berel, Dror; Cook-Wiens, Galen; Bresee, Catherine; Li, Quanlin; Rogatko, André
In this paper, we present the design and implementation of a novel web portal for the cancer phase I clinical trial design method Escalation with Overdose Control (EWOC). The web portal has two major components: a web-based dose finding calculator; and a standalone and downloadable dose finding software which can be installed on Windows operating systems. The web-based dose finding calculator uses industry standards and is a database-driven and distributed computing platform for designing and conducting dose finding in cancer phase I clinical trials utilizing EWOC methodology. The web portal is developed using open source software: PHP, JQuery, R and OpenBUGS. It supports any standard browsers with internet connection. The web portal can be accessed at: http://biostatistics.csmc.edu.
Boucher, Andy; Cameron, David; Gaver, William; Hauenstein, Mark; Jarvis, Nadine; Kerridge, Tobie; Michael, Mike; Ovalle, Liliana; Pennington, Sarah; Wilkie, Alex
Web Science 2015 conference exhibition. Web Science is the emergent study of the people and technologies, applications, processes and practices that shape and are shaped by the World Wide Web. Web Science aims to draw together theories, methods and findings from across academic disciplines, and to collaborate with industry, business, government and civil society, to develop knowledge and understanding of the Web: the largest socio-technical infrastructure in human history.
This paper describes about the need for Web project management, fundamentals of project management for web projects: what it is, why projects go wrong, and what's different about web projects. We also discuss Cost Estimation Techniques based on Size Metrics. Though Web project development is similar to traditional software development applications, the special characteristics of Web Application development requires adaption of many software engineering approaches or even development of comple...
Ontologies and reasoning are the key terms brought into focus by the semantic web community. Formal representation of ontologies in a common data model on the web can be taken as a foundation for adaptive web technologies as well. This chapter describes how ontologies shared on the semantic web...... provide conceptualization for the links which are a main vehicle to access information on the web. The subject domain ontologies serve as constraints for generating only those links which are relevant for the domain a user is currently interested in. Furthermore, user model ontologies provide additional...... means for deciding which links to show, annotate, hide, generate, and reorder. The semantic web technologies provide means to formalize the domain ontologies and metadata created from them. The formalization enables reasoning for personalization decisions. This chapter describes which components...
Francely M. Fernandes
Full Text Available Lucilia cuprina (Wiedemann, 1830 is a cosmopolite blowfly species of medical and veterinary importance because it produces myiasis, mainly in ovine. In order to evaluate the demographic characteristics of this species, survivorship curves for 327 adult males and 323 adult females, from generation F1 maintained under experimental conditions, were obtained. Entropy was utilized as the estimator of the survival pattern to quantify the mortality distribution of individuals as a function of age. The entropy values 0.216 (males and 0.303 (females were obtained. These results denote that, considering the survivorship interval until the death of the last individual for each sex, the males present a tendency of mortality in more advanced age intervals, in comparison with the females.
Hanschmidt, Franz; Lehnig, Franziska; Riedel-Heller, Steffi G.; Kersting, Anette
Background considerable proportion of the population experiences major life disruptions after losing a loved one to suicide. Social stigma attached to suicide survivors adds to complications occurring in the course of suicide bereavement. Despite its known risks, stigma related to suicide survivors has been sparsely investigated. Methods We conducted a systematic literature search in PubMed, Web of Science, PsycInfo and PsyArticles, of studies indexed up through August 2015. Articles were eligible for inclusion if they addressed experiences of stigma in suicide survivors, compared them to other bereavement populations, or investigated stigmatizing attitudes within the public. The search was restricted to English-language studies. Results 25 records matched inclusion criteria. Study designs were heterogeneous, making comparisons difficult. Results demonstrated that suicide survivors experience stigma in the form of shame, blame, and avoidance. Suicide survivors showed higher levels of stigma than natural death survivors. Stigma was linked to concealment of the death, social withdrawal, reduced psychological and somatic functioning, and grief difficulties. Only one study investigated stigmatizing attitudes towards suicide survivors among the general population. Limitations Internal and external validity of the studies was restricted by a lack of valid measures and selection bias. Conclusions More methodologically sound research is needed to understand the impact of stigma on suicide survivors’ grief trajectories and to separate it from other grief aspects. Clinicians and grief-counselors as well as the public should be educated about the persistent stigma experienced by suicide survivors. PMID:27657887
Jessen, Iben Bredahl; Graakjær, Nicolai Jørgensgaard
Sound seems to be a neglected issue in the study of web ads. Web advertising is predominantly regarded as visual phenomena–commercial messages, as for instance banner ads that we watch, read, and eventually click on–but only rarely as something that we listen to. The present chapter presents...... an overview of the auditory dimensions in web advertising: Which kinds of sounds do we hear in web ads? What are the conditions and functions of sound in web ads? Moreover, the chapter proposes a theoretical framework in order to analyse the communicative functions of sound in web advertising. The main...... argument is that an understanding of the auditory dimensions in web advertising must include a reflection on the hypertextual settings of the web ad as well as a perspective on how users engage with web content....
Full Text Available In the past decade, developing countries have been experiencing rapid land use and land cover changes, including deforestation and cultivation of previously forested land. However, little is known about the impact of deforestation and land-use changes on the life history of malaria vectors and their effects on malaria transmission. This study examined the effects of deforestation and crop cultivation on the adult survivorship of major malaria mosquitoes, Anopheles sinensis and An. minimus in the China-Myanmar border region. We examined three conditions: indoor, forested, and banana plantation. Mean survival time of An. sinensis in banana plantation environment was significantly longer than those in forested environment, and mosquitoes exhibited the longest longevity in the indoor environment. This pattern held for both males and females, and also for An. minimus. To further test the effect of temperature on mosquito survival, we used two study sites with different elevation and ambient temperatures. Significantly higher survivorship of both species was found in sites with lower elevation and higher ambient temperature. Increased vector survival in the deforested area could have an important impact on malaria transmission in Southeast Asia. Understanding how deforestation impacts vector survivorship can help combat malaria transmission.
Zhong, Daibin; Wang, Xiaoming; Xu, Tielong; Zhou, Guofa; Wang, Ying; Lee, Ming-Chieh; Hartsel, Joshua A; Cui, Liwang; Zheng, Bin; Yan, Guiyun
In the past decade, developing countries have been experiencing rapid land use and land cover changes, including deforestation and cultivation of previously forested land. However, little is known about the impact of deforestation and land-use changes on the life history of malaria vectors and their effects on malaria transmission. This study examined the effects of deforestation and crop cultivation on the adult survivorship of major malaria mosquitoes, Anopheles sinensis and An. minimus in the China-Myanmar border region. We examined three conditions: indoor, forested, and banana plantation. Mean survival time of An. sinensis in banana plantation environment was significantly longer than those in forested environment, and mosquitoes exhibited the longest longevity in the indoor environment. This pattern held for both males and females, and also for An. minimus. To further test the effect of temperature on mosquito survival, we used two study sites with different elevation and ambient temperatures. Significantly higher survivorship of both species was found in sites with lower elevation and higher ambient temperature. Increased vector survival in the deforested area could have an important impact on malaria transmission in Southeast Asia. Understanding how deforestation impacts vector survivorship can help combat malaria transmission.
BEST PRACTICES TO CREATE AND IMPLEMENTHIGHLY EFFECTIVE WEB SURVEYS Exclusively combining design and sampling issues, Handbook of Web Surveys presents a theoretical yet practical approach to creating and conducting web surveys. From the history of web surveys to various modes of data collection to tips for detecting error, this book thoroughly introduces readers to the this cutting-edge technique and offers tips for creating successful web surveys. The authors provide a history of web surveys and go on to explore the advantages and disadvantages of this mode of dat
Web 2.0 is a highly accessible introductory text examining all the crucial discussions and issues which surround the changing nature of the World Wide Web. It not only contextualises the Web 2.0 within the history of the Web, but also goes on to explore its position within the broader dispositif of emerging media technologies.The book uncovers the connections between diverse media technologies including mobile smart phones, hand-held multimedia players, ""netbooks"" and electronic book readers such as the Amazon Kindle, all of which are made possible only by the Web 2.0. In addition, Web 2.0 m
Cimprich, Bernadine; Janz, Nancy K; Northouse, Laurel; Wren, Patricia A; Given, Barbara; Given, Charles W
The purpose of the study was to develop and evaluate Taking CHARGE, a self-management intervention designed to facilitate successful transitions to survivorship after breast cancer treatment. The Taking CHARGE intervention involves a two-pronged approach building on self-regulation principles to (1) equip women with self-management skills to address concerns following breast cancer treatment, and (2) provide information about common survivorship topics. The program involved four intervention contacts, two small group meetings and two individualized telephone sessions, delivered by nurse/health educators. This paper focuses on the process evaluation findings from a preliminary test of the Taking CHARGE intervention conducted with 25 women, aged 34-66 years, completing breast cancer treatment, who were randomly assigned to the intervention group. The process evaluation was conducted to obtain systematic information about the relevance and usefulness of the self-regulation approach, informational aspects, and program delivery. The findings indicated that intervention group participants found the Taking CHARGE program to be timely, relevant, and to have high utility in dealing with concerns that exist following breast cancer treatment. The process evaluation findings provide early evidence of the usefulness of the Taking CHARGE intervention for successful transition to survivorship following breast cancer treatment.
Midtgaard, Julie; Hammer, Nanna Maria; Andersen, Christina
BACKGROUND: Evidence for the safety and benefits of exercise training as a therapeutic and rehabilitative intervention for cancer survivors is accumulating. However, whereas the evidence for the efficacy of exercise training has been established in several meta-analyses, synthesis of qualitative......, age 28-76 years) exclusively reporting experiences of participation in structured, supervised exercise training resulted in nine themes condensed into three categories: 1) emergence of continuity; 2) preservation of health; and 3) reclaiming the body reflecting the benefits of exercise...... research is lacking. In order to extend healthcare professionals' understanding of the meaningfulness of exercise in cancer survivorship care, this paper aims to identify, appraise and synthesize qualitative studies on cancer survivors' experience of participation in exercise-based rehabilitation. MATERIAL...
Yeung, Daniel; Boes, Peter; Ho, Meng Wei; Li, Zuofeng
Image-guided radiotherapy (IGRT), based on radiopaque markers placed in the prostate gland, was used for proton therapy of prostate patients. Orthogonal X-rays and the IBA Digital Image Positioning System (DIPS) were used for setup correction prior to treatment and were repeated after treatment delivery. Following a rationale for margin estimates similar to that of van Herk,(1) the daily post-treatment DIPS data were analyzed to determine if an adaptive radiotherapy plan was necessary. A Web application using ASP.NET MVC5, Entity Framework, and an SQL database was designed to automate this process. The designed features included state-of-the-art Web technologies, a domain model closely matching the workflow, a database-supporting concurrency and data mining, access to the DIPS database, secured user access and roles management, and graphing and analysis tools. The Model-View-Controller (MVC) paradigm allowed clean domain logic, unit testing, and extensibility. Client-side technologies, such as jQuery, jQuery Plug-ins, and Ajax, were adopted to achieve a rich user environment and fast response. Data models included patients, staff, treatment fields and records, correction vectors, DIPS images, and association logics. Data entry, analysis, workflow logics, and notifications were implemented. The system effectively modeled the clinical workflow and IGRT process.
The effects of short-term exposure of stage 25 Litoria citropa tadpoles to sublethal concentrations of endosulfan in combination with either a stable or a variable temperature cycle (20+/-2 vs. 21+/-7.5 degrees C) were investigated. Both exposure to 0.8 microg/l endosulfan and the wider temperature range over 96 h had significant adverse effects on survivorship. In addition, variable water temperatures at the time of endosulfan exposure increased tadpoles' vulnerability to predation by odonates 24 days later, but only if they had also been exposed to endosulfan. This effect occurred despite maintenance of all tadpoles at 19+/-1 degrees C during the intervening 24 days. Correlates of fitness such as this represent a move towards more biologically relevant experimental endpoints. This is an important step if we are to gain an understanding of how exposure to agricultural chemicals may affect frog populations in the natural environment. The results indicate that a short, pulsed exposure to a sublethal concentration of endosulfan and extremes in temperature may then have long-term impacts on fitness.
Schimanski, Kate B; Piola, Richard F; Goldstien, Sharyn J; Floerl, Oliver; Grandison, Clare; Atalah, Javier; Hopkins, Grant A
The likelihood that viable non-indigenous biofouling species will survive a voyage on a vessel is influenced by a range of factors, including the speed, duration, and route of the voyage and the amount of time the vessel spends in port. In this study, a land-based dynamic flow device was used to test the effect of recruit age, vessel speed and voyage duration on the survivorship and growth of the bryozoan Bugula neritina. In the experiment, one-week-old recruits had a higher likelihood (100%) of surviving voyages than older (one-month-old, 90%) or younger (one-day-old, 79%) recruits, but survival was not influenced by vessel speed (6 and 18 knots) or voyage duration (two and eight days). The results suggest that the non-indigenous species B. neritina can be effectively transferred at a range of ages but one-week-old recruits are more likely to survive the translocation process and survive in the recipient environment.
Full Text Available The World Wide Web as the largest information construct has had much progress since its advent. Thispaper provides a background of the evolution of the web from web 1.0 to web 4.0. Web 1.0 as a web ofinformation connections, Web 2.0 as a web of people connections, Web 3.0 as a web of knowledgeconnections and web 4.0 as a web of intelligence connections are described as four generations of the webin the paper.
Ratnayake, Rakhitha Nimesh
This book is intended for WordPress developers and designers who want to develop quality web applications within a limited time frame and for maximum profit. Prior knowledge of basic web development and design is assumed.
U.S. Environmental Protection Agency — The Chemical Search Web Utility is an intuitive web application that allows the public to easily find the chemical that they are interested in using, and which...
U.S. Environmental Protection Agency — EPA's Web Taxonomy is a faceted hierarchical vocabulary used to tag web pages with terms from a controlled vocabulary. Tagging enables search and discovery of EPA's...
This book is perfect for beginners who want to get started and learn the web development basics, but also offers experienced developers a web development roadmap that will help them to extend their capabilities.
Thygesen, Marianne Kirstine; Holt, Kamila Adellund; Mogensen, Ole
Cancer patients can experience a low self-management, which is associated with burn out and negatively associated with health-related quality of life. Patient-provider time at hospitals is often short and patients can lack knowledge, communication and support. We aimed to evaluate the influence o...
Blaauwbroek, R.; Barf, H. A.; Groenier, K. H.; Kremer, L. C.; van der Meer, K.; Tissing, W. J. E.; Postma, A.
To facilitate family doctor-driven follow-up for adult childhood cancer survivors, we developed a survivor care plan (SCP) for adult survivors and their family doctors. The SCP was accessible for survivors and their family doctors on a secure website and as a printed booklet. It included data on dia
Bol, N; Bergstrom, J.C.R.; Smets, E.M.A.; Loos, Eugène; Strohl, J.; van Weert, J.C.M.
This study examines how adults pay attention to cognitive and affective illustrations on a cancer-related webpage and explores age-related differences in the attention to these cognitive and affective webpages. Results of an eye-tracking experiment (n = 20) showed that adults spent more time attendi
Bol, N.; Romano Bergstrom, J.C.; Smets, E.M.A.; Loos, E.F.; Strohl, J.; van Weert, J.C.M.; Stephanidis, C.; Antona, M.
This study examines how adults pay attention to cognitive and affective illustrations on a cancer-related webpage and explores age-related differences in the attention to these cognitive and affective webpages. Results of an eye-tracking experiment (n = 20) showed that adults spent more time attendi
The World Wide Web bas become an important platform for developing and running applications. A vital process while developing web applications is the choice of web technologies, on which the application will be build. The developers face a dizzying array of platforms, languages, frameworks and technical artifacts to choose from. The decison carries consequences on most other decisions in the development process. Thesis contains analisis, classifications and comparison of web technologies s...
Fuentes, José María de; Corella, Miguel Ángel; Castells, Pablo; Rico, Mariano
Proceedings of the IADIS International Conference WWW/Internet 2005, held in Lisbon (Portugal). The lack of a critical mass of actually deployed web services, semantic or not, is an important hurdle for the advancement and further innovation in web service technologies. In this paper we introduce Federica, a platform for semi-automatic generation and implementation of semantic web services by exploiting existing web applications published in internet. Federica generates semantical...
王实; 高文; 李锦涛
Web Mining is an important branch in Data Mining.It attracts more research interest for rapidly developing Internet. Web Mining includes:(1)Web Content Mining;(g)Web Usage Mining;(3) Web structure Mining.In this paper we define Web Mining and present an overview of the various research issues,techniques and development efforts.
Zhongda Lin; Kun Deng; Yanfen Hong
In this paper, we discuss several issues related to automated classification of web pages, especially text classification of web pages. We analyze features selection and categorization algorithms of web pages and give some suggestions for web pages categorization.
Thomsen, Jakob Grauenkjær; Ernst, Erik; Brabrand, Claus
We present WebSelF, a framework for web scraping which models the process of web scraping and decomposes it into four conceptually independent, reusable, and composable constituents. We have validated our framework through a full parameterized implementation that is flexible enough to capture...
Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks. Short, concise recipes to learn a variety of useful web scraping techniques using PHP.This book is aimed at those new to web scraping, with little or no previous programming experience. Basic knowledge of HTML and the Web is useful, but not necessary.
Luján Mora, Sergio
Presentaciones del curso "Web Browser Programming" impartido en la Université M'Hamed Bougara (Bourmerdes, Argelia) en junio de 2006. Proyecto financiado por la Unión Europea: TEMPUS JEP-32102-2004, Licence Professionnelle Technologies des Applications Web (Professional License for Web Application Technologies).
The World Wide Web is emerging as an all-in-one information source. Tools for searching Web-based information include search engines, subject directories and meta search tools. We take a look at key features of these tools and suggest practical hints for effective Web searching.
Mai, Jens Erik
This paper discusses the challenges faced by investigations into the classification of the Web and outlines inquiries that are needed to use principles for bibliographic classification to construct classifications of the Web. This paper suggests that the classification of the Web meets challenges...
Snider, Jean; Martin, Florence
Web usability focuses on design elements and processes that make web pages easy to use. A website for college students was evaluated for underutilization. One-on-one testing, focus groups, web analytics, peer university review and marketing focus group and demographic data were utilized to conduct usability evaluation. The results indicated that…
... uses a surgical tool to remove the tumor.Mohs' surgery. Layers of cancer cells are removed one ... usually have not been approved by the U.S. Food and Drug Administration (FDA). The medicine may have ...
P. V. G. S. Mudiraj B. Jabber K. David raju
Full Text Available Web usage mining is a main research area in Web mining focused on learning about Web users and their interactions with Web sites. The motive of mining is to find users’ access models automatically and quickly from the vast Web log data, such as frequent access paths, frequent access page groups and user clustering. Through web usage mining, the server log, registration information and other relative information left by user provide foundation for decision making of organizations. This article provides a survey and analysis of current Web usage mining systems and technologies. There are generally three tasks in Web Usage Mining: Preprocessing, Pattern analysis and Knowledge discovery. Preprocessing cleans log file of server by removing log entries such as error or failure and repeated request for the same URL from the same host etc... The main task of Pattern analysis is to filter uninteresting information and to visualize and interpret the interesting pattern to users. The statistics collected from the log file can help to discover the knowledge. This knowledge collected can be used to take decision on various factors like Excellent, Medium, Weak users and Excellent, Medium and Weak web pages based on hit counts of the web page in the web site. The design of the website is restructured based on user’s behavior or hit counts which provides quick response to the web users, saves memory space of servers and thus reducing HTTP requests and bandwidth utilization. This paper addresses challenges in three phases of Web Usage mining along with Web Structure Mining.This paper also discusses an application of WUM, an online Recommender System that dynamically generates links to pages that have not yet been visited by a user and might be of his potential interest. Differently from the recommender systems proposed so far, ONLINE MINER does not make use of any off-line component, and is able to manage Web sites made up of pages dynamically generated.
Wen Liu; Lauren Schaffer; Natalie Herrs; Christine Chollet; Sarah Taylor
Objective: Sleep disorder and fatigue are among a few major concerns of breast cancer survivors across the survivorship trajectory. The purpose of this pilot study was to examine feasibility and trends in multiple outcomes after a 6-week Qigong exercise program in breast cancer survivors. Methods: Eight female adults (mean age 55.4 ± 9.4 years, mean time after the completion of cancer treatment 3.9 ± 5.7 years) who had a diagnosis of breast cancer and were at least 3 months postcompletion of ...
Interfacing to the Web or programming interfaces for the Web is used to provide dynamic information for Web users. Using the Web as a transport system of information poses three constraints: namespace, statelessness and performance. To build interfaces on either server or client side of the Web one has to meet these constraints. Several examples, currently in use in High Energy Physics Experiments are described. They range from an interface to show where buildings are located to an interface showing active values of the On-line System of the DELPHI (CERN)..
Since the first edition of this classic reference was published, World Wide Web use has exploded and e-commerce has become a daily part of business and personal life. As Web use has grown, so have the threats to our security and privacy--from credit card fraud to routine invasions of privacy by marketers to web site defacements to attacks that shut down popular web sites. Web Security, Privacy & Commerce goes behind the headlines, examines the major security risks facing us today, and explains how we can minimize them. It describes risks for Windows and Unix, Microsoft Internet Exp
Bouguettaya, Athman; Daniel, Florian
Web services and Service-Oriented Computing (SOC) have become thriving areas of academic research, joint university/industry research projects, and novel IT products on the market. SOC is the computing paradigm that uses Web services as building blocks for the engineering of composite, distributed applications out of the reusable application logic encapsulated by Web services. Web services could be considered the best-known and most standardized technology in use today for distributed computing over the Internet.Web Services Foundations is the first installment of a two-book collection coverin
Ajax and web services are a perfect match for developing web applications. Ajax has built-in abilities to access and manipulate XML data, the native format for almost all REST and SOAP web services. Using numerous examples, this document explores how to fit the pieces together. Examples demonstrate how to use Ajax to access publicly available web services fromYahoo! and Google. You'll also learn how to use web proxies to access data on remote servers and how to transform XML data using XSLT.
AbiGhannam, Niveen; Chilek, Lindsay A; Koh, Hyeseung E
Breast cancer advocacy has experienced tremendous success since the 1980s. Yet, the quality and authenticity of breast cancer information in the media are sometimes questionable. Using a content analysis, we examined the informative (donation information, breast cancer advocacy content, etc.) and persuasive (appeals used, cues to action, etc.) contents of magazine advertisements relevant to breast cancer. While ads offered minimal informative content about the disease or about ways by which sales will contribute to the breast cancer cause, they integrated "breast cancer appeals," such as the color pink, the pink ribbon, and mostly positive depictions of survivorship and hope, into the ads. Breast cancer thus took center stage in the persuasive content of the ads, but a back seat when it came to their informative content. We discuss the implications of those findings in light of the meanings and purposes of cause-related marketing campaigns.
Carpentier, Melissa Y; Fortenberry, J Dennis
This review presents a summary of existing knowledge regarding the effect of testicular cancer along four broad domains, including romantic and sexual relationships, body image, and fertility. A total of 37 studies were reviewed. Of note, most research consists of older adult testicular cancer survivors, with very little research attention afforded to adolescent and young adult survivorship. Relationship status (i.e., partnered versus unpartnered) appears to play an important role as it relates to adjustment outcomes in testicular cancer survivors. In addition, sexual function (and thereby fertility) and body image are also frequently compromised. Implications regarding a lack of developmentally focused research on adolescent and young adult testicular cancer survivorship are discussed, along with recommendations for new research.
Plough, L V; Shin, G; Hedgecock, D
The offspring of most highly fecund marine fish and shellfish suffer substantial mortality early in the life cycle, complicating prediction of recruitment and fisheries management. Early mortality has long been attributed to environmental factors and almost never to genetic sources. Previous work on a variety of marine bivalve species uncovered substantial genetic inviability among the offspring of inbred crosses, suggesting a large load of early-acting deleterious recessive mutations. However, genetic inviability of randomly bred offspring has not been addressed. Here, genome-wide surveys reveal widespread, genotype-dependent mortality in randomly bred, full-sib progenies of wild-caught Pacific oysters (Crassostrea gigas). Using gene-mapping methods, we infer that 11-19 detrimental alleles per family render 97.9-99.8% of progeny inviable. The variable genomic positions of viability loci among families imply a surprisingly large load of partially dominant or additive detrimental mutations in wild adult oysters. Although caution is required in interpreting the relevance of experimental results for natural field environments, we argue that the observed genetic inviability corresponds with type III survivorship, which is characteristic of both hatchery and field environments and that our results, therefore, suggest the need for additional experiments under the near-natural conditions of mesocosms. We explore the population genetic implications of our results, calculating a detrimental mutation rate that is comparable to that estimated for conifers and other highly fecund perennial plants. Genetic inviability ought to be considered as a potential major source of low and variable recruitment in highly fecund marine animals.
Morgan S. Pratchett
Full Text Available The dispersal potential of crown-of-thorns starfish (CoTS larvae is important in understanding both the initiation and spread of population outbreaks, and is fundamentally dependent upon how long larvae can persist while still retaining the capacity to settle. This study quantified variation in larval survivorship and settlement rates for CoTS maintained at three different densities of a single-celled flagellate phytoplankton, Proteomonas sulcata (1 × 103, 1 × 104, and 1 × 105 cells/mL. Based on the larval starvation hypothesis, we expected that low to moderate levels of phytoplankton prey would significantly constrain both survival and settlement. CoTS larvae were successfully maintained for up to 50 days post-fertilization, but larval survival differed significantly between treatments. Survival was greatest at intermediate food levels (1 × 104 cells/mL, and lowest at high (1 × 105 cells/mL food levels. Rates of settlement were also highest at intermediate food levels and peaked at 22 days post-fertilization. Peak settlement was delayed at low food levels, probably reflective of delayed development, but there was no evidence of accelerated development at high chlorophyll concentrations. CoTS larvae were recorded to settle 17–43 days post-fertilization, but under optimum conditions with intermediate algal cell densities, peak settlement occurred at 22 days post-fertilization. Natural fluctuations in nutrient concentrations and food availability may affect the number of CoTS that effectively settle, but seem unlikely to influence dispersal dynamics.
DR. ANURADHA; BABITA AHUJA
In this era of digital tsunami of information on the web, everyone is completely dependent on the WWW for information retrieval. This has posed a challenging problem in extracting relevant data. Traditional web crawlers focus only on the surface web while the deep web keeps expanding behind the scene. The web databases are hidden behind the query interfaces. In this paper, we propose a Hidden Web Extractor (HWE) that can automatically discover and download data from the Hidden Web databases. ...
von Wenckstern, Michael
Full Text Available Web Mining is becoming essential to support the web administrators and web users in multi-ways such as information retrieval; website performance management; web personalization; web marketing and website designing. Due to uncontrolled exponential growth in web data, knowledge base retrieval has become a very challenging task. The one viable solution to the problem is the merging of conventional web mining with semantic web technologies. This merging process will be more beneficial to web users by reducing the search space and by providing information that is more relevant. Key web objects play significant role in this process. The extraction of key web objects from a website is a challenging task. In this paper, we have proposed a framework, which extracts the key web objects from web log file and apply a semantic web to mine actionable intelligence. This proposed framework can be applied to non-semantic web for the extraction of key web objects. We also have defined an objective function to calculate key web object from users perspective. We named this function as key web object function. KWO function helps to fuzzify the extracted key web objects into three categories as Most Interested, Interested, and Least Interested. Fuzzification of web objects helps us to accommodate the uncertainty among the web objects of being user attractive. We also have validated the proposed scheme with the help of a case study.
Knobf, M Tish; Winters-Stone, Kerri
There are an estimated 13.7 million cancer survivors in the United States. Persistent and late effects of cancer therapy have contributed to an increased risk for co-morbid illness and higher all-cause mortality. Physical exercise is a targeted rehabilitative intervention following cancer therapy and a health promotion risk reduction intervention for patients as they transition into survivorship. This chapter provides a brief overview of the research on exercise and cancer survivor outcomes with a specific focus on randomized controlled trials (RCT) on the effects of exercise on body composition and bone health. There were 17 RCT trials that were identified with body composition outcomes. There was no change in weight in 16/17 trials, 4 reported decreases in percent fat mass and 2 reported increases in lean mass. Eight exercise trials were identified with bone outcomes, two of which had pharmacologic comparison arms. These trials demonstrated preservation of bone in the intervention group compared with loss in the usual care or placebo control group. The majority of trials were with breast cancer survivors, the largest survivor group. Many are overweight or obese at diagnosis; weight gain continues to increase after therapy; and treatment is associated with bone loss. The findings of the 25 trials reviewed suggest that exercise maintains weight and bone mass in a high risk population. However, differences in design, measurement of body composition and bone mass and lack of targeted exercise to the specific outcomes warrants additional research to improve the quality of life for survivors.
Hodges, Kayleigh; Winstanley, Sue
The psychological impact of a cancer diagnosis can extend through treatment, well into cancer survivorship and can be influenced by a range of psychosocial resources. At different stages in this trajectory, optimism is known to affect well-being directly. This study focusing upon the potential to flourish after cancer, investigates the relationship between optimism and positive affect during cancer survivorship together with four possible mediators: social support, fighting spirit, internal health locus of control and cancer worry, all of which have been shown to be important predictors of well-being in cancer patients. Participants (n = 102) from online cancer forums completed standardized questionnaires, and path analysis confirmed that optimism had a direct effect on positive affect in cancer survivors. Social support and fighting spirit were also shown to be significant mediators of this relationship, accounting collectively for 50% of the variance in positive affect. Whilst cancer worry and internal health locus of control could be predicted from levels of optimism, they did not mediate the optimism-positive affect relationship. Efforts to promote optimism and thus encourage fighting spirit at diagnosis through treatment may be worthwhile interventions, as would ensuring appropriate social support through the trajectory.
Chen, Hsinchun; Li, Xin; Chau, M.; Ho, Yi-Jen; Tseng, Chunju
With the advent of the World Wide Web, many business applications that utilize data mining and text mining techniques to extract useful business information on the Web have evolved from Web searching to Web mining. It is important for students to acquire knowledge and hands-on experience in Web mining during their education in information systems…
Full Text Available The rapid increase in the number and variety of resources on the World Wide Web has made the problem of resource description and discovery central to discussions about the efficiency and evolution of this medium. The inappropriateness of traditional schemas of resource description for web resources has encouraged significant activities recently on defining web-compatible schemas named "metadata". While conceptually old for library and information professionals, metadata has taken more significant and paramount role than ever before and is considered as the golden key for the next evolution of the web in the form of semantic web. This article is intended to be a brief introduction to metadata and tries to present its overview in the web.
Chris B. Kingsley
Full Text Available Recent advances in high throughput biological methods allow researchers to generate enormous amounts of data from a single experiment. In order to extract meaningful conclusions from this tidal wave of data, it will be necessary to develop analytical methods of sufficient power and utility. It is particularly important that biologists themselves be able to perform many of these analyses, such that their background knowledge of the experimental system under study can be used to interpret results and direct further inquiries. We have developed a web-based system, Magellan, which allows the upload, storage, and analysis of multivariate data and textual or numerical annotations. Data and annotations are treated as abstract entities, to maximize the different types of information the system can store and analyze. Annotations can be used in analyses/visualizations, as a means of subsetting data to reduce dimensionality, or as a means of projecting variables from one data type or data set to another. Analytical methods are deployed within Magellan such that new functionalities can be added in a straightforward fashion. Using Magellan, we performed an integrated analysis of genome-wide comparative genomic hybridization (CGH, mRNA expression, and clinical data from ovarian tumors. Analyses included the use of permutation-based methods to identify genes whose mRNA expression levels correlated with patient survival, a nearest neighbor classifier to predict patient survival from CGH data, and curated annotations such as genomic position and derived annotations such as statistical computations to explore the quantitative relationship between CGH and mRNA expression data.
Kingsley, Chris B; Kuo, Wen-Lin; Polikoff, Daniel; Berchuck, Andy; Gray, Joe W; Jain, Ajay N
Recent advances in high throughput biological methods allow researchers to generate enormous amounts of data from a single experiment. In order to extract meaningful conclusions from this tidal wave of data, it will be necessary to develop analytical methods of sufficient power and utility. It is particularly important that biologists themselves be able to perform many of these analyses, such that their background knowledge of the experimental system under study can be used to interpret results and direct further inquiries. We have developed a web-based system, Magellan, which allows the upload, storage, and analysis of multivariate data and textual or numerical annotations. Data and annotations are treated as abstract entities, to maximize the different types of information the system can store and analyze. Annotations can be used in analyses/visualizations, as a means of subsetting data to reduce dimensionality, or as a means of projecting variables from one data type or data set to another. Analytical methods are deployed within Magellan such that new functionalities can be added in a straightforward fashion. Using Magellan, we performed an integrated analysis of genome-wide comparative genomic hybridization (CGH), mRNA expression, and clinical data from ovarian tumors. Analyses included the use of permutation-based methods to identify genes whose mRNA expression levels correlated with patient survival, a nearest neighbor classifier to predict patient survival from CGH data, and curated annotations such as genomic position and derived annotations such as statistical computations to explore the quantitative relationship between CGH and mRNA expression data.
本文以实际项目为例介绍了J2EE中Axis框架下一个Web Service的完整开发过程,包括Axis下Web Service的编写方式和安装部署,基于JDOM的XML操作方法,并给出了以JSP页面作客户端调用Web Service的参考代码.
Among the tests you perform on web applications, security testing is perhaps the most important, yet it's often the most neglected. The recipes in the Web Security Testing Cookbook demonstrate how developers and testers can check for the most common web security issues, while conducting unit tests, regression tests, or exploratory tests. Unlike ad hoc security assessments, these recipes are repeatable, concise, and systematic-perfect for integrating into your regular test suite.
Building a web application that attracts and retains regular visitors is tricky enough, but creating a social application that encourages visitors to interact with one another requires careful planning. This book provides practical solutions to the tough questions you'll face when building an effective community site -- one that makes visitors feel like they've found a new home on the Web. If your company is ready to take part in the social web, this book will help you get started. Whether you're creating a new site from scratch or reworking an existing site, Building Social Web Applications
Today's market for mobile apps goes beyond the iPhone to include BlackBerry, Nokia, Windows Phone, and smartphones powered by Android, webOS, and other platforms. If you're an experienced web developer, this book shows you how to build a standard app core that you can extend to work with specific devices. You'll learn the particulars and pitfalls of building mobile apps with HTML, CSS, and other standard web tools. You'll also explore platform variations, finicky mobile browsers, Ajax design patterns for mobile, and much more. Before you know it, you'll be able to create mashups using Web 2.
While the REST design philosophy has captured the imagination of web and enterprise developers alike, using this approach to develop real web services is no picnic. This cookbook includes more than 100 recipes to help you take advantage of REST, HTTP, and the infrastructure of the Web. You'll learn ways to design RESTful web services for client and server applications that meet performance, scalability, reliability, and security goals, no matter what programming language and development framework you use. Each recipe includes one or two problem statements, with easy-to-follow, step-by-step i
Full Text Available Internet changed the perspective on meetings and also on decision making processes. Virtualization of meetings has become a common way for collaboration among employees, customers, partners, trainees and trainers, etc. Web conferencing allows the collaboration between teams' members to achieve common goals. Without the need of travelling and meeting organization, the web conferencing applications permit the participation of people from different location. Web conferencing applications are multimedia systems that allow various remote collaborations with multiple types of resources. The paper presents an exploratory study on multimedia web conferencing systems, its advantages and disadvantages and also a use case, meant to highlight several of this technology benefits and problems.
Segaran, Toby; Taylor, Jamie
With this book, the promise of the Semantic Web -- in which machines can find, share, and combine data on the Web -- is not just a technical possibility, but a practical reality Programming the Semantic Web demonstrates several ways to implement semantic web applications, using current and emerging standards and technologies. You'll learn how to incorporate existing data sources into semantically aware applications and publish rich semantic data. Each chapter walks you through a single piece of semantic technology and explains how you can use it to solve real problems. Whether you're writing
White, C D
Webs are sets of Feynman diagrams that contribute to the exponents of scattering amplitudes, in the kinematic limit in which emitted radiation is soft. As such, they have a number of phenomenological and formal applications, and offer tantalising glimpses into the all-order structure of perturbative quantum field theory. This article is based on a series of lectures given to graduate students, and aims to provide a pedagogical introduction to webs. Topics covered include exponentiation in (non-)abelian gauge theories, the web mixing matrix formalism for non-abelian gauge theories, and recent progress on the calculation of web diagrams. Problems are included throughout the text, to aid understanding.
This book constitutes the thoroughly refereed post conference proceedings of the first edition of the Semantic Web Evaluation Challenge, SemWebEval 2014, co-located with the 11th Extended Semantic Web conference, held in Anissaras, Crete, Greece, in May 2014. This book includes the descriptions of all methods and tools that competed at SemWebEval 2014, together with a detailed description of the tasks, evaluation procedures and datasets. The contributions are grouped in three areas: semantic publishing (sempub), concept-level sentiment analysis (ssa), and linked-data enabled recommender systems (recsys).
The easiest way to learn how to create a Web page for your family or organization Do you want to share photos and family lore with relatives far away? Have you been put in charge of communication for your neighborhood group or nonprofit organization? A Web page is the way to get the word out, and Creating Web Pages Simplified offers an easy, visual way to learn how to build one. Full-color illustrations and concise instructions take you through all phases of Web publishing, from laying out and formatting text to enlivening pages with graphics and animation. This easy-to-follow visual guide sho
Bouguettaya, Athman; Daniel, Florian
Web services and Service-Oriented Computing (SOC) have become thriving areas of academic research, joint university/industry research projects, and novel IT products on the market. SOC is the computing paradigm that uses Web services as building blocks for the engineering of composite, distributed applications out of the reusable application logic encapsulated by Web services. Web services could be considered the best-known and most standardized technology in use today for distributed computing over the Internet. This book is the second installment of a two-book collection covering the state-o
White, C. D.
Webs are sets of Feynman diagrams that contribute to the exponents of scattering amplitudes, in the kinematic limit in which emitted radiation is soft. As such, they have a number of phenomenological and formal applications, and offer tantalizing glimpses into the all-order structure of perturbative quantum field theory. This article is based on a series of lectures given to graduate students, and aims to provide a pedagogical introduction to webs. Topics covered include exponentiation in (non-)abelian gauge theories, the web mixing matrix formalism for non-abelian gauge theories, and recent progress on the calculation of web diagrams. Problems are included throughout the text, to aid understanding.
Discover the latest trends in web design! Looking for inspiration for your latest web design project? Expert Patrick McNeil, author of the popular Web Designer's Idea Book series, is back with all new examples of today's best website design. Featuring more than 650 examples of the latest trends, this fourth volume of The Web Designer's Idea Book is overflowing with visual inspiration. Arranged categorically, this fully illustrated guide puts important topics like design styles, elements, themes and responsive design at your fingertips. This new volume also includes a detailed discussion o
Harper, Simon; Yesilada, Yeliz
Access to, and movement around, complex online environments, of which the World Wide Web (Web) is the most popular example, has long been considered an important and major issue in the Web design and usability field. The commonly used slang phrase ‘surfing the Web’ implies rapid and free access, pointing to its importance among designers and users alike. It has also been long established that this potentially complex and difficult access is further complicated, and becomes neither rapid nor free, if the user is disabled. There are millions of people who have disabilities that affect their use of the Web. Web accessibility aims to help these people to perceive, understand, navigate, and interact with, as well as contribute to, the Web, and thereby the society in general. This accessibility is, in part, facilitated by the Web Content Accessibility Guidelines (WCAG) currently moving from version one to two. These guidelines are intended to encourage designers to make sure their sites conform to specifications, and in that conformance enable the assistive technologies of disabled users to better interact with the page content. In this way, it was hoped that accessibility could be supported. While this is in part true, guidelines do not solve all problems and the new WCAG version two guidelines are surrounded by controversy and intrigue. This chapter aims to establish the published literature related to Web accessibility and Web accessibility guidelines, and discuss limitations of the current guidelines and future directions.
Dixit, Niharika; Crawford, Gregory B; Lemonde, Manon; Rittenberg, Cynthia N; Fernández-Ortega, Paz
Huge advances have been made in cancer treatments over recent decades; however, significant disparities still exist in the developed world on the basis of race, socioeconomic status, education level, geographical location, and immigration status and in the United States, insurance status. Cancer disparities persist in the continuum of cancer care from risk factors, screening, diagnosis, treatment, survivorship, and end-of-life care. The causes of disparities are complex and multifactorial. The MASCC (Multinational Association of Supportive Care in Cancer) Education Study Group would like to propose a framework of cancer disparities from a social perspective utilizing "social determinants of health" as delineated by the World Health Organization and highlight an unmet need for research and policy innovations to address cancer disparities in developed world.
Xu, Guandong; Zhang, Yanchun; Li, Lin
sense of individuals or communities. The volume will benefit both academic and industry communities interested in the techniques and applications of web search, web data management, web mining and web knowledge discovery, as well as web community and social network analysis.......This book examines the techniques and applications involved in the Web Mining, Web Personalization and Recommendation and Web Community Analysis domains, including a detailed presentation of the principles, developed algorithms, and systems of the research in these areas. The applications of web...... mining, and the issue of how to incorporate web mining into web personalization and recommendation systems are also reviewed. Additionally, the volume explores web community mining and analysis to find the structural, organizational and temporal developments of web communities and reveal the societal...
Full Text Available There are many carcinogenetic elements in industry and it is for this reason that study and research concerning the effect of these materials is carried out on a national and international level. The establishment and growth of cancer are affected by different factors in two main areas:-1 The nature of the human or animal including sex, age, point and method of entry, fat metabolism, place of agglomeration of carcinogenetic material, amount of material absorbed by the body and the immunity of the body.2 The different nature of the carcinogenetic material e.g. physical, chemical quality, degree of solvency in fat and purity of impurity of the element. As the development of cancer is dependent upon so many factors, it is extremely difficult to determine whether a causative element is principle or contributory. Some materials are not carcinogenetic when they are pure but become so when they combine with other elements. All of this creates an industrial health problem in that it is almost impossible to plan an adequate prevention and safety program. The body through its system of immunity protects itself against small amounts of carcinogens but when this amount increases and reaches a certain level the body is not longer able to defend itself. ILO advises an effective protection campaign against cancer based on the Well –equipped laboratories, Well-educated personnel, the establishment of industrial hygiene within factories, the regular control of safety systems, and the implementation of industrial health principles and research programs.
Agha, Mickey; Lovich, Jeffrey E; Ennen, Joshua R; Augustine, Benjamin; Arundel, Terence R; Murphy, Mason O; Meyer-Wilkins, Kathie; Bjurlin, Curtis; Delaney, David; Briggs, Jessica; Austin, Meaghan; Madrak, Sheila V; Price, Steven J
With the recent increase in utility-scale wind energy development, researchers have become increasingly concerned how this activity will affect wildlife and their habitat. To understand the potential impacts of wind energy facilities (WEF) post-construction (i.e., operation and maintenance) on wildlife, we compared differences in activity centers and survivorship of Agassiz's desert tortoises (Gopherus agassizii) inside or near a WEF to neighboring tortoises living near a wilderness area (NWA) and farther from the WEF. We found that the size of tortoise activity centers varied, but not significantly so, between the WEF (6.25 ± 2.13 ha) and adjacent NWA (4.13 ± 1.23 ha). However, apparent survival did differ significantly between the habitat types: over the 18-year study period apparent annual survival estimates were 0.96 ± 0.01 for WEF tortoises and 0.92 ± 0.02 for tortoises in the NWA. High annual survival suggests that operation and maintenance of the WEF has not caused considerable declines in the adult population over the past two decades. Low traffic volume, enhanced resource availability, and decreased predator populations may influence annual survivorship at this WEF. Further research on these proximate mechanisms and population recruitment would be useful for mitigating and managing post-development impacts of utility-scale wind energy on long-lived terrestrial vertebrates.
Agha, Mickey; Lovich, Jeffrey E.; Ennen, Joshua R.; Augustine, Benjamin; Arundel, Terence R.; Murphy, Mason O.; Meyer-Wilkins, Kathie; Bjurlin, Curtis; Delaney, David; Briggs, Jessica; Austin, Meaghan; Madrak, Sheila V.; Price, Steven J.
With the recent increase in utility-scale wind energy development, researchers have become increasingly concerned how this activity will affect wildlife and their habitat. To understand the potential impacts of wind energy facilities (WEF) post-construction (i.e., operation and maintenance) on wildlife, we compared differences in activity centers and survivorship of Agassiz's desert tortoises ( Gopherus agassizii) inside or near a WEF to neighboring tortoises living near a wilderness area (NWA) and farther from the WEF. We found that the size of tortoise activity centers varied, but not significantly so, between the WEF (6.25 ± 2.13 ha) and adjacent NWA (4.13 ± 1.23 ha). However, apparent survival did differ significantly between the habitat types: over the 18-year study period apparent annual survival estimates were 0.96 ± 0.01 for WEF tortoises and 0.92 ± 0.02 for tortoises in the NWA. High annual survival suggests that operation and maintenance of the WEF has not caused considerable declines in the adult population over the past two decades. Low traffic volume, enhanced resource availability, and decreased predator populations may influence annual survivorship at this WEF. Further research on these proximate mechanisms and population recruitment would be useful for mitigating and managing post-development impacts of utility-scale wind energy on long-lived terrestrial vertebrates.
Agha, Mickey; Lovich, Jeffrey E.; Ennen, Joshua R.; Augustine, Benjamin J.; Arundel, Terry; Murphy, Mason O.; Meyer-Wilkins, Kathie; Bjurlin, Curtis; Delaney, David F.; Briggs, Jessica; Austin, Meaghan; Madrak, Sheila V.; Price, Steven J.
With the recent increase in utility-scale wind energy development, researchers have become increasingly concerned how this activity will affect wildlife and their habitat. To understand the potential impacts of wind energy facilities (WEF) post-construction (i.e., operation and maintenance) on wildlife, we compared differences in activity centers and survivorship of Agassiz's desert tortoises (Gopherus agassizii) inside or near a WEF to neighboring tortoises living near a wilderness area (NWA) and farther from the WEF. We found that the size of tortoise activity centers varied, but not significantly so, between the WEF (6.25 ± 2.13 ha) and adjacent NWA (4.13 ± 1.23 ha). However, apparent survival did differ significantly between the habitat types: over the 18 year study period apparent annual survival estimates were 0.96 ± 0.01 for WEF tortoises and 0.92 ± 0.02 for tortoises in the NWA. High annual survival suggests that operation and maintenance of the WEF has not caused considerable declines in the adult population over the past two decades. Low traffic volume, enhanced resource availability and decreased predator populations may influence annual survivorship at this WEF. Further research on these proximate mechanisms and population recruitment would be useful for mitigating and managing post-development impacts of utility scale wind energy on long-lived terrestrial vertebrates.
Nicholson, J; Ritchie, S A; Russell, R C; Webb, C E; Cook, A; Zalucki, M P; Williams, C R; Ward, P; van den Hurk, A F
The presence of Aedes albopictus (Skuse) in the Torres Strait of northern Australia increases the potential for colonization and establishment on the mainland. However, there is a possibility that native species that occupy the same habitats may influence the population performance of Ae. albopictus, potentially affecting the establishment of this species in Australia. Cohabitation experiments were performed with the endemic Aedes notoscriptus (Skuse), which has been found occupying the same larval habitats as Ae. albopictus in the Torres Strait and is the most widespread container-inhabiting Aedes species in Australia. The influence of environmental factors and cohabitation between the two species was examined using different climates, food resource levels, food resource types, and species densities. Survivorship proportions and a population performance index (λ') were calculated and compared. The consequences of increased Ae. notoscriptus densities were reduced survivorship and λ' for Ae. albopictus. Despite this, the mean λ' of Ae. albopictus and Ae. notoscriptus was consistently ≥ 1.06, indicating both species could increase under all conditions, potentially due to increasing conspecific densities negatively affecting Ae. notoscriptus. The outcomes from this study suggest that the preexisting presence of Ae. notoscriptus may not prevent the establishment of Ae. albopictus in Australia.
"Ten years ago, CERN issued a statement declaring that a little known piece of software called the World Wide Web was in the public domain. That was on 30 April 1993, and it opened the floodgates to Web development around the world" (1 page).
Designing a web home page involves many decisions that affect how the page will look, the kind of technology required to use the page, the links the page will provide, and kinds of patrons who can use the page. The theme of information literacy needs to be built into every web page; users need to be taught the skills of sorting and applying…
If you are a web programmer with experience in developing web services and have a rudimentary knowledge of using Go, then this is the book for you. Basic knowledge of Go as well as knowledge of relational databases and non-relational NoSQL datastores is assumed. Some basic concurrency knowledge is also required.
Samar, T.; Huurdeman, H.C.; Ben-David, A.; Kamps, J.; Vries, A.P. de
Many national and international heritage institutes realize the importance of archiving the web for future culture heritage. Web archiving is currently performed either by harvesting a national domain, or by crawling a pre-defined list of websites selected by the archiving institution. In either met
Walker, Tim; Donohue, Chip
More than ever, early childhood administrators are relying on the Internet for information. A key to becoming an exceptional Web "surfer" is getting to know the ins and outs of the Web browser being used. There are several options available, and almost all can be downloaded for free. However, many of the functions and features they offer are very…
Fels, Deborah I.; Richards, Jan; Hardman, Jim; Lee, Daniel G.
The World Wide Web has changed the way people interact. It has also become an important equalizer of information access for many social sectors. However, for many people, including some sign language users, Web accessing can be difficult. For some, it not only presents another barrier to overcome but has left them without cultural equality. The…
Poorly organized and dominated by amateurs, hucksters, and marketeers, the net requires efficient navigating devices. Students at Bellingham (Washington) Public Schools tackle information overload by contributing to virtual museums on school Web sites, using annotated Web curriculum lists, and conducting research in cooperative teams stressing…
The web site is a library's most important feature. Patrons use the web site for numerous functions, such as renewing materials, placing holds, requesting information, and accessing databases. The homepage is the place they turn to look up the hours, branch locations, policies, and events. Whether users are at work, at home, in a building, or on…
Hatton, Ross; Otto, Andrew; Elias, Damian
Due to their poor eyesight, spiders rely on web vibrations for situational awareness. Web-borne vibrations are used to determine the location of prey, predators, and potential mates. The influence of web geometry and composition on web vibrations is important for understanding spider's behavior and ecology. Past studies on web vibrations have experimentally measured the frequency response of web geometries by removing threads from existing webs. The full influence of web structure and tension distribution on vibration transmission; however, has not been addressed in prior work. We have constructed physical artificial webs and computer models to better understand the effect of web structure on vibration transmission. These models provide insight into the propagation of vibrations through the webs, the frequency response of the bare web, and the influence of the spider's mass and stiffness on the vibration transmission patterns. Funded by NSF-1504428.
Full Text Available Mikaela L Jorgensen,1 Jane M Young,1,2 Michael J Solomon2,3 1Cancer Epidemiology and Services Research (CESR, Sydney School of Public Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; 2Surgical Outcomes Research Centre (SOuRCe, Sydney Local Health District and University of Sydney, Sydney, NSW, Australia; 3Discipline of Surgery, University of Sydney, Sydney, NSW, Australia Abstract: Colorectal cancer (CRC is the third most commonly diagnosed cancer worldwide. With population aging and increases in survival, the number of CRC survivors is projected to rise dramatically. The time following initial treatment is often described as a period of transition from intensive hospital-based care back into “regular life.” This review provides an overview of recommended follow-up care for people with CRC who have been treated with curative intent, as well as exploring the current state of the research that underpins these guidelines. For patients, key concerns following treatment include the development of recurrent and new cancers, late and long-term effects of cancer and treatment, and the interplay of these factors with daily function and general health. For physicians, survivorship care plans can be a tool for coordinating the surveillance, intervention, and prevention of these key patient concerns. Though much of the research in cancer survivorship to date has focused on surveillance for recurrent disease, many national guidelines differ in their conclusions about the frequency and timing of follow-up tests. Most CRC guidelines refer only briefly to the management of side effects, despite reports that many patients have a range of ongoing physiological, psychosocial, and functional needs. Guidance for surveillance and intervention is often limited by a small number of heterogeneous trials conducted in this patient group. However, recently released survivorship guidelines emphasize the potential for the effectiveness of
Dukes, Mark; McAslan, Heather; Scott, Darren J; White, Chris D
The non-Abelian exponentiation theorem has recently been generalised to correlators of multiple Wilson line operators. The perturbative expansions of these correlators exponentiate in terms of sets of diagrams called webs, which together give rise to colour factors corresponding to connected graphs. The colour and kinematic degrees of freedom of individual diagrams in a web are entangled by mixing matrices of purely combinatorial origin. In this paper we relate the combinatorial study of these matrices to properties of partially ordered sets (posets), and hence obtain explicit solutions for certain families of web-mixing matrix, at arbitrary order in perturbation theory. We also provide a general expression for the rank of a general class of mixing matrices, which governs the number of independent colour factors arising from such webs. Finally, we use the poset language to examine a previously conjectured sum rule for the columns of web-mixing matrices which governs the cancellation of the leading subdivergen...
suit the user profile the most. This paper summarizes the domain engineering framework for such adaptive web applications. The framework provides guidelines to develop adaptive web applications as members of a family. It suggests how to utilize the design artifacts as knowledge which can be used......Information and services on the web are accessible for everyone. Users of the web differ in their background, culture, political and social environment, interests and so on. Ambient intelligence was envisioned as a concept for systems which are able to adapt to user actions and needs....... With the growing amount of information and services, the web applications become natural candidates to adopt the concepts of ambient intelligence. Such applications can deal with divers user intentions and actions based on the user profile and can suggest the combination of information content and services which...
Knobf, M Tish
Being adequately prepared for an experience such as cancer empowers patients, lowers distress, improves coping, supports self-management, promotes recovery, and improves quality of life. However, patients with cancer report unmet informational and support needs across the cancer trajectory. The purpose of this article is to describe the relationship of information preparation and patient outcomes, identify information and support needs across the cancer trajectory, and describe the role of oncology nurses in the delivery of high-quality patient-centered cancer care. The middle range theory of "Carrying On" was used to identify information and support needs during different phases of the cancer trajectory from treatment to survivorship. The authors concluded that nurses should engage the patient in a relational exchange of information; provide concrete, understandable information across specific times in the cancer experience; and use creative approaches to minimize barriers in meeting patient needs to achieve high-quality patient-centered cancer care.
Sanchis-Gomar, Fabian; Lucia, Alejandro; Yvert, Thomas; Ruiz-Casado, Ana; Pareja-Galeano, Helios; Santos-Lozano, Alejandro; Fiuza-Luces, Carmen; Garatachea, Nuria; Lippi, Giuseppe; Bouchard, Claude; Berger, Nathan A.
Sedentary lifestyle is associated with elevated cancer risk whereas regular physical activity (PA) and high cardiorespiratory fitness (CRF) have the opposite effect, with several biological mechanisms mediating such associations. There is a need for lifestyle interventions aimed at increasing the PA levels and CRF of the general population and particularly cancer survivors. Further, provocative data suggest a dose-dependent benefit of increasing levels of PA and/or CRF against cancer risk or mortality. Thus, current PA guidelines (≥150 min/week of moderate-to-vigorous PA) may not be sufficiently rigorous for preventing cancer nor for extending cancer survivorship. Research targeting this issue is urgently needed. Promoting regular PA along with monitoring indicators of CRF and adiposity may provide powerful strategies to prevent cancer in populations, help cancer patients more effectively deal with their disease and enhance secondary prevention programs in those who are affected by cancer. PMID:25416409
... will see specialists (in cardiology , endocrinology , fertility , nutrition , psychology , and/or pulmonology , for example) who will monitor your child’s health. These clinics are usually found within hospitals. If the hospital ...
Syme, Maggie L; Delaney, Eileen; Wachen, Jennifer Schuster; Gosian, Jeffrey; Moye, Jennifer
Little is known about the sexual well-being of male Veteran cancer survivors, or the relationship of sexual concerns to psychosocial adaptation postcancer. This study examined the association between sexual self-esteem and psychosocial concerns in male Veteran cancer survivors. Forty-one male survivors were recruited from a Veterans Affairs (VA) hospital to participate in a pilot study addressing cancer survivorship care for Veterans. Sixty- to 90-minute interviews were conducted, assessing sociodemographic, medical, stress/burden (cancer-related posttraumatic stress disorder [PTSD], depression), and resource (social support, post-traumatic growth) variables. Twenty-one (51.2%) Veteran cancer survivors reported lowered sexual self-esteem as a result of cancer, which corresponded to significantly higher levels of depression and cancer-related PTSD. The lowered sexual self-esteem group also indicated significantly lower social support. Veteran cancer survivors with lowered sexual self-esteem tend to have higher levels of stress and lower levels of resources, putting them at risk for lowered quality of life. This increased risk highlights the importance of addressing sexual well-being in the survivorship care of Veterans.
Liu, Lifang; O'Donnell, Peter; Sullivan, Richard; Katalinic, Alexander; Moser, Lotte; de Boer, Angela; Meunier, Francoise
With so many adults and children receiving successful treatment for their cancer, survivorship is now a 'new' and critical issue. It is increasingly recognised that the growing numbers of survivors face new challenges in their bid to return to 'normal' life. What is not yet so widely recognised is the need for a broad response to help them cope-with stigmatisation, misunderstanding, lifelong issues of confidence and social adaptation, and even access to employment and to financial services. As a further stage in its programme of attention to this aspect of cancer, the European Organisation for Research and Treatment of Cancer (EORTC) brought survivors, researchers, carers, authorities and policymakers together at a meeting in Brussels in March/April 2016, to learn at first hand about the posttreatment experience of cancer survivors. The meeting demonstrated that while research is well advanced in many of the medical consequences of survivorship, understanding is still lacking of many non-clinical, personal and administrative issues. The meeting raised the discussion of survivorship research beyond the individual to a population-based approach, exploring the related socioeconomic issues. Its exploration of initiatives across Europe countries provoked new thinking on the need for effective collaboration, with a new focus on non-clinical issues, including effective dialogue with financial service providers and employers, improvements in collecting, exchanging and accessing data, and above all, ways of translating research outcomes into action. This will require wider recognition that, as Françoise Meunier, Director Special Projects, EORTC, said, 'It is time for a new mind set'.
Tomasone, J.R.; Zwaal, C.; Kim, G.; Yuen, D.; Sussman, J.; Segal, R.
The need for an improved understanding of the rehabilitation services landscape in Ontario and for promotion of Cancer Care Ontario’s newly developed Exercise for People with Cancer guideline brought Cancer Care Ontario’s Psychosocial Oncology and Survivorship Programs together to host a knowledge translation and exchange event. The primary objectives of the event were to understand recommendations from Cancer Care Ontario’s new exercise guideline, to discuss key considerations and determine strategies for the implementation of the guideline recommendations, and to explore the current state and future directions of cancer rehabilitation in Ontario. The event was attended by 124 stakeholders, including clinicians, allied health care professionals, administrators, patients, community partners, and academics representing each of the 13 regional cancer programs in Ontario. Attendees participated in two small-group activities that focused on determining the best approach for implementing the guideline recommendations into practice and discussing current barriers and the future state of cancer rehabilitation in Ontario. The activities allowed for networking and collaboration between attendees. The event provided an opportunity for the Psychosocial Oncology and Survivorship Programs to learn about the types of goals and plans that could be feasible in implementing the guideline in each region, and about ways to prioritize gaps in access to rehabilitation services and the types of implementation strategies that might be used to address the gaps. Overall, attendees were highly satisfied with the event, and the findings are being used to help inform research and practice activities with respect to guideline implementation and rehabilitation practice.
Vinson, Cynthia; La Porta, Madeline; Todd, William; Palafox, Neal A; Wilson, Katherine M; Fairley, Temeika
The goal of cancer control research is "to generate basic knowledge about how to monitor and change individual and collective behavior and to ensure that knowledge is translated into practice and policy rapidly, effectively, and efficiently" (Division of Cancer Control and Population Sciences in Cancer control framework and synthese rationale, 2010). Research activities span the cancer control continuum from prevention to early detection and diagnosis through treatment and survivorship (Division of Cancer Control and Population Sciences in Cancer control framework and synthese rationale, 2010). While significant advancements have been made in understanding, preventing and treating cancer in the past few decades, these benefits have yielded disproportionate results in cancer morbidity and mortality across various socioeconomic and racial/ethnic subgroups (Ozols et al in J Clin Oncol, 25(1):146-1622, 2007). It has been a high priority since the beginning of the Comprehensive Cancer Control (CCC) movement to utilize research in the development and implementation of cancer plans in the states, tribes and tribal organizations, territories and US Pacific Island Jurisdictions. Nevertheless, dissemination and implementation of research in coalition activities has been challenging for many programs. Lessons learned from programs and coalitions in the implementation and evaluation of CCC activities, as well as resources provided by national partners, can assist coalitions with the translation of research into practice.
A. K. Santra
Full Text Available The World Wide Web is a distributed internet system, which provides dynamic and interactive services includes on line tutoring, video/audio conferencing, e-commerce, and etc., which generated heavy demand on network resources and web servers. It increase over the past few year at a very rapidly rate, due to which the amount of traffic over the internet is increasing. As a result, the network performance has now become very slow. Web Pre-fetching and Caching is one of the effective solutions to reduce the web access latency and improve the quality of service. The existing model presented a Cluster based pre-fetching scheme identified clusters of correlated Web pages based on users access patterns. Web Pre-fetching and Caching cause significant improvements on the performance of Web infrastructure. In this paper, we present an efficient Cluster based Web Object Filters from Web Pre-fetching and Web caching scheme to evaluate the web user navigation patterns and user references of product search. Clustering of web page objects obtained from pre-fetched and web cached contents. User Navigation is evaluated from the web cluster objects with similarity retrieval in subsequent user sessions. Web Object Filters are built with the interpretation of the cluster web pages related to the unique users by discarding redundant pages. Ranking is done on users web page product preferences at multiple sessions of each individual user. The performance is measured in terms of Objective function, Number of clusters and cluster accuracy.
What do Amazon's product reviews, eBay's feedback score system, Slashdot's Karma System, and Xbox Live's Achievements have in common? They're all examples of successful reputation systems that enable consumer websites to manage and present user contributions most effectively. This book shows you how to design and develop reputation systems for your own sites or web applications, written by experts who have designed web communities for Yahoo! and other prominent sites. Building Web Reputation Systems helps you ask the hard questions about these underlying mechanisms, and why they're critical
Web services are poised to become a key technology for a wide range of Internet-enabled applications, spanning everything from straight B2B systems to mobile devices and proprietary in-house software. While there are several tools and platforms that can be used for building web services, developers are finding a powerful tool in Microsoft's .NET Framework and Visual Studio .NET. Designed from scratch to support the development of web services, the .NET Framework simplifies the process--programmers find that tasks that took an hour using the SOAP Toolkit take just minutes. Programming .NET
SRD 69 NIST Chemistry WebBook (Web, free access) The NIST Chemistry WebBook contains: Thermochemical data for over 7000 organic and small inorganic compounds; thermochemistry data for over 8000 reactions; IR spectra for over 16,000 compounds; mass spectra for over 33,000 compounds; UV/Vis spectra for over 1600 compounds; electronic and vibrational spectra for over 5000 compounds; constants of diatomic molecules(spectroscopic data) for over 600 compounds; ion energetics data for over 16,000 compounds; thermophysical property data for 74 fluids.
This book addresses the problem of benchmarking Semantic Web Technologies; first, from a methodological point of view, proposing a general methodology to follow in benchmarking activities over Semantic Web Technologies and, second, from a practical point of view, presenting two international benchmarking activities that involved benchmarking the interoperability of Semantic Web technologies using RDF(S) as the interchange language in one activity and OWL in the other.The book presents in detail how the different resources needed for these interoperability benchmarking activities were defined:
Full Text Available Web browser merupakan alat bagi pengguna untuk melakukan penelusuran di lingkungan Internet baik berupa teks (hypertext maupun gambar, suara atau video (hypermedia yang tersusun secara sistematis dalam suatu Web. Dokumen/teks tersebut sering terdiri dari beberapa halarnan atau bahkan hanya 1 halaman, saling berhubungan dengan dokumen lain melalui tanda tertentu (hyperlink yang biasanya berbentuk huruf-huruf yang berwama lain dan lebih bercahaya atau 'highlighted'. Pengguna yang tertarik untuk mengetahui informasi dari dunia hiburan sampai dengan ilmu pengetahuan, cukup menunjuk dan menekan tombol mouse pada bagian tersebut dalam Web browser, sehingga tampilan akan berpindah dari dokumen satu ke dokumen lain.
Radhakrishnan, Sabarinathan; Tafer, Hakim; Seemann, Ernst Stefan;
, are derived from extensive pre-computed tables of distributions of substitution effects as a function of gene length and GC content. Here, we present a web service that not only provides an interface for RNAsnp but also features a graphical output representation. In addition, the web server is connected...... to a local mirror of the UCSC genome browser database that enables the users to select the genomic sequences for analysis and visualize the results directly in the UCSC genome browser. The RNAsnp web server is freely available at: http://rth.dk/resources/rnasnp/....
Hyldegård, Jette; Lund, Haakon
The paper presents the results from a study on information literacy in a higher education (HE) context based on a larger research project evaluating 3 Norwegian IL web tutorials at 6 universities and colleges in Norway. The aim was to evaluate how the 3 web tutorials served students’ information...... seeking and writing process in an study context and to identify barriers to the employment and use of the IL web tutorials, hence to the underlying information literacy intentions by the developer. Both qualitative and quantitative methods were employed. A clear mismatch was found between intention...
Want to know how to make your pages look beautiful, communicate your message effectively, guide visitors through your website with ease, and get everything approved by the accessibility and usability police at the same time? Head First Web Design is your ticket to mastering all of these complex topics, and understanding what's really going on in the world of web design. Whether you're building a personal blog or a corporate website, there's a lot more to web design than div's and CSS selectors, but what do you really need to know? With this book, you'll learn the secrets of designing effecti
The rapid advancement of semantic web technologies, along with the fact that they are at various levels of maturity, has left many practitioners confused about the current state of these technologies. Focusing on the most mature technologies, Applied Semantic Web Technologies integrates theory with case studies to illustrate the history, current state, and future direction of the semantic web. It maintains an emphasis on real-world applications and examines the technical and practical issues related to the use of semantic technologies in intelligent information management. The book starts with
Graham, M. J.
Web services are a cornerstone of the distributed computing infrastructure that the VO is built upon yet to the newcomer, they can appear to be a black art. This perception is not helped by the miasma of technobabble that pervades the subject and the seemingly impenetrable high priesthood of actual users. In truth, however, there is nothing conceptually difficult about web services (unsurprisingly any complexities will lie in the implementation details) nor indeed anything particularly new. A web service is a piece of software available over a network with a formal description of how it is called and what it returns that a computer can understand. Note that entities such as web servers, ftp servers and database servers do not generally qualify as they lack the standardized description of their inputs and outputs. There are prior technologies, such as RMI, CORBA, and DCOM, that have employed a similar approach but the success of web services lies predominantly in its use of standardized XML to provide a language-neutral way for representing data. In fact, the standardization goes further as web services are traditionally (or as traditionally as five years will allow) tied to a specific set of technologies (WSDL and SOAP conveyed using HTTP with an XML serialization). Alternative implementations are becoming increasingly common and we will cover some of these here. One important thing to remember in all of this, though, is that web services are meant for use by computers and not humans (unlike web pages) and this is why so much of it seems incomprehensible gobbledegook. In this chapter, we will start with an overview of the web services current in the VO and present a short guide on how to use and deploy a web service. We will then review the different approaches to web services, particularly REST and SOAP, and alternatives to XML as a data format. We will consider how web services can be formally described and discuss how advanced features such as security, state
Khelghati, Mohammad; Hiemstra, Djoerd; Keulen, van Maurice
The change of the web content is rapid. In Focused Web Harvesting [?], which aims at achieving a complete harvest for a given topic, this dynamic nature of the web creates problems for users who need to access a complete set of related web data to their interesting topics. Whether you are a fan foll
Khelghati, Mohammad; Hiemstra, Djoerd; Keulen, van Maurice
Web content changes rapidly . In Focused Web Harvesting  which aim it is to achieve a complete harvest for a given topic, this dynamic nature of the web creates problems for users who need to access a set of all the relevant web data to their topics of interest. Whether you are a fan followi
JIA Wenjue; CHEN Yumin; GONG Jianya
OGC Web Map Service is one kind of OGC Portrayal Services belongs to OGC Web Service model and it provides multi-platform interoperability of spatial data set. This paper presents a method for implementing OGC Web Map Service based on Web Service technique and introduces the detailed process.
濒危的大熊猫(Ailuropoda melanoleuca)是中国四川、甘肃和陕西省山区所特有的物种。该种在20世纪70年代有2000多只。由于生境缩小、偷猎和竹林开花等原因所致，到20世纪90年代，大熊猫种群的数量下降到不足1000只，且分离成32个亚种群。在过去的30多年中，大量竹林开花和开花后死亡是大熊猫种群数量下降的主要原因。70年代，整个岷山的大熊猫遭受饥荒，80年代蔓延到琼莱山，造成大熊猫大量死亡。大熊猫的生境被分离成很多小的"岛"，每个小的生存地只有几只熊猫，使得大熊猫的生存形式进一步恶化。小的、孤立的大熊猫种群变的更加脆弱，很容易受到生境退化、自然灾害、疾病和近亲繁殖的威胁，从而导致灭绝。因此，对于保护野生大熊猫来说，恢复大熊猫的生境并把大熊猫重新引回到它们的历史生境中去，是一个重要的研究课题。%The endangered giant panda (Ailuropoda melanoleuca) is endemic to the mountains of Sichuan, Gansu and Shaanxi Provinces in China. The species had numbered over 2000 animals in early 1970s, but declined to no more than 1,000 animals fragmented into perhaps 32 subpopulations in late 1990s as the result of numerous detrimental forces such as habitat shrinking, poaching and bamboo flowering. The mass flowering and followed die-off of bamboo played key roles in the declination of panda population in the past three decades. It trigged the starvation and following high mortality of giant pandas in 1970s over Min Mountains and in 1980s across Qionglai Mountains in Sichuan Province. The situation of survivorship is made worse by the fact that the panda habitat is fragmented into many small "islands", each containing only a few pandas. Such small, isolated panda populations are rendered even more vulnerable to extinction form threats such as habitat degradation, natural disaster, disease, and the deleterious
Learn to build dynamic web sites with Microsoft WebMatrix Microsoft WebMatrix is designed to make developing dynamic ASP.NET web sites much easier. This complete Wrox guide shows you what it is, how it works, and how to get the best from it right away. It covers all the basic foundations and also introduces HTML, CSS, and Ajax using jQuery, giving beginning programmers a firm foundation for building dynamic web sites.Examines how WebMatrix is expected to become the new recommended entry-level tool for developing web sites using ASP.NETArms beginning programmers, students, and educators with al
Performance is critical to the success of any web site, and yet today's web applications push browsers to their limits with increasing amounts of rich content and heavy use of Ajax. In this book, Steve Souders, web performance evangelist at Google and former Chief Performance Yahoo!, provides valuable techniques to help you optimize your site's performance. Souders' previous book, the bestselling High Performance Web Sites, shocked the web development world by revealing that 80% of the time it takes for a web page to load is on the client side. In Even Faster Web Sites, Souders and eight exp
Full Text Available Total hip replacement (THR is successful in treating hip arthritis. Prosthetic survivorship may depend on the medications taken by the patient; particularly, the role of benzodiazepines and related drugs (Z-drugs with THR revision has been poorly investigated. Our objective was to compare THR short-term survivorship according to level of exposure to benzodiazepine and Z-drugs.All French patients aged 40 years or older, having undergone primary THR from January 1, 2009, through December 31, 2012, for arthritis according to French national health insurance databases were included in the cohort. Outcome of interest was THR revision, including any surgical procedure in which the implant or any component was changed or removed. Follow-up started the day the primary THR was performed. Observations were right-censored on December 31, 2014, if neither revision nor death had yet occurred. Exposure of interest was the cumulative defined daily doses per day (cDDD/day of benzodiazepines and Z-drugs dispensed within 6 months before or after inclusion. We defined four exposure groups; cDDD/d = 0: unexposed; 0.38: high exposure. THR survivorship was assessed according to level of exposure to benzodiazepines and Z-drugs in univariate and multivariate Cox models adjusted for patient, THR and implanting center characteristics.The study cohort comprised 246,940 individuals: mean age at baseline, 69.9 years; women, 57.9%; unexposed: 51.7%; low exposure: 16.7%; medium exposure: 15.9%; and high exposure: 15.7%. During the median 45-month follow-up, 9043 individuals underwent prosthetic revision. Adjusted hazard ratios in low, medium and high exposed groups were 1.18 (95%CI, 1.12-1.26; P<0.001, 1.32 (95%CI, 1.24-1.40; P<0.001 and 1.37 (95%CI, 1.29-1.45; P<0.001, respectively, compared to unexposed.Exposure to benzodiazepines and Z-drugs is associated with an increased risk of THR revision, with a dose-response relationship. Cautious prescribing might be needed as well
Lopez-Class, Maria; Perret-Gentil, Monique; Kreling, Barbara; Caicedo, Larisa; Mandelblatt, Jeanne; Graves, Kristi D
Breast cancer is the most common cancer among Latinas. This study examined social, cultural, and health care system factors that impact the quality of life and survivorship experiences of Latina immigrant breast cancer survivors. We interviewed Latina breast cancer survivors (n = 19) and, based on the interview findings, conducted two focus groups (n = 9). Research staff translated transcripts from Spanish into English. Two trained raters reviewed the content and identified themes. Thematic content analysis was used to categorize and organize data. Participants were largely monolingual in Spanish, predominantly from Central and South America and most (68%) had lived in the U.S. for ten or more years. All women were diagnosed and treated in the U.S. and were an average of 3.1 years from diagnosis. Women's survivorship experiences appeared to be shaped by cultural beliefs and experiences as immigrants such as secrecy/shame about a breast cancer diagnosis, feelings of isolation, importance of family support (familism), challenges with developing social relationships in the U.S. (less personalismo), and, for some, their partner's difficulty with showing emotional support (machismo). Navigating the U.S. medical system and language barriers were additional challenges in the participants' health care interactions. Latina breast cancer survivors adhere to certain cultural values and face unique issues as immigrants, potentially influencing overall quality of life and doctor-patient communication. Efforts to improve Latina immigrant breast cancer survivors' quality of life could include increased assessment of psychosocial functioning and referral to social support services, culturally sensitive navigation programs, and consistent use of appropriately trained interpreters.
Omenetto, Fiorenzo G.; Kaplan, David L.
A study reveals that spider orb webs fail in a nonlinear fashion, owing to the hierarchical organization of the silk proteins. The discovery may serve as inspiration for engineers for the design of aerial, light-weight, robust architectures.
Caters to an under-served niche market of small and medium-sized web consulting projects Eases people's project management pain Uses a clear, simple, and accessible style that eschews theory and hates walls of text
The same question posed on the Web and in print can yield very different answers, dramatically distorting survey results and misleading management. But, as psychologist Palmer Morrel-Samuels demonstrates, the problems are readily fixed.
Department of Transportation — A web service that allows end-users the ability to query the current known delays in the National Airspace System as well as the current weather from NOAA by airport...
L.K. Joshila Grace
Full Text Available Log files contain information about User Name, IP Address, Time Stamp, Access Request, number of Bytes Transferred, Result Status, URL that Referred and User Agent. The log files are maintained by the web servers. By analysing these log files gives a neat idea about the user. This paper gives a detailed discussion about these log files, their formats, their creation, access procedures, their uses, various algorithms used and the additional parameters that can be used in the log files which in turn gives way to an effective mining. It also provides the idea of creating an extended log file and learning the user behaviour.
Grace, L K Joshila; Nagamalai, Dhinaharan
Log files contain information about User Name, IP Address, Time Stamp, Access Request, number of Bytes Transferred, Result Status, URL that Referred and User Agent. The log files are maintained by the web servers. By analysing these log files gives a neat idea about the user. This paper gives a detailed discussion about these log files, their formats, their creation, access procedures, their uses, various algorithms used and the additional parameters that can be used in the log files which in turn gives way to an effective mining. It also provides the idea of creating an extended log file and learning the user behaviour.
对Web的演变过程及存在的问题进行了分析;对语义Web 基本原理和架构做了介绍;在此基础上, 主要是从不同的技术角度、多种指标对语义Web与Web异同进行了分析讨论;并仅对基于Web的几个方面的应用,做了简要介绍.
Chen, Hsiang; Wigand, R. T.; Nilan, M. S.
Reports on Web users' optimal flow experiences to examine positive aspects of Web experiences that could be linked to theory applied to other media and then incorporated into Web design. Discusses the use of content-analytic procedures to analyze open-ended questionnaires that examined Web users' perceived flow experiences. (Author/LRW)
Recently, a new web development technique for creating interactive web applications, dubbed AJAX, has emerged in response to the limited degree of interactivity in large-grain stateless web interactions. In this new model, the web interface is composed of individual components which can be updated/r
介绍了语义Web的概念及本体模型在其中的运用,比较了XML/XML Schema和RDF/RDF Schema在语义表示方面的使用,提出RDF(S)更适合于语义Web;最后讨论了扩展RDF开发语义Web应用所应该注意的问题.
Gómez Hidalgo, José María; Puertas Sanz, Enrique; Carrero García, Francisco Manuel; Buenaga Rodríguez, Manuel de
Across the years, Internet has evolved from an academic network to a truly communication medium, reaching impressive levels of audience and becoming a billionaire business. Many of our working, studying, and entertainment activities are nowadays overwhelmingly limited if we get disconnected from the net of networks. And of course, with the use comes abuse. The World Wide Web features a wide variety of content that are harmful for children or just inappropriate in the workplace. Web filtering ...
Metson, S; Bockelman, B; Dziedziniewicz, K; Egeland, R; Elmer, P; Eulisse, G; Evans, D; Fanfani, A; Feichtinger, D; Kavka, C; Kuznetsov, V; Van Lingen, F; Newbold, D; Tuura, L; Wakefield, S
We describe a relatively new effort within CMS to converge on a set of web based tools, using state of the art industry techniques, to engage with the CMS offline computing system. CMS collaborators require tools to monitor various components of the computing system and interact with the system itself. The current state of the various CMS web tools is described along side current planned developments.
White, C. D.
Webs are sets of Feynman diagrams that contribute to the exponents of scattering amplitudes, in the kinematic limit in which emitted radiation is soft. As such, they have a number of phenomenological and formal applications, and offer tantalising glimpses into the all-order structure of perturbative quantum field theory. This article is based on a series of lectures given to graduate students, and aims to provide a pedagogical introduction to webs. Topics covered include exponentiation in (no...
Web services are a common and standard way to implement communication between information systems and provide documented interfaces. The Web services are usually using SOAP because it is a widely-spread, well-documented and used standard. SOAP standard defines a message structure, an envelope, that is sent over internet using HTTP and contains XML data. An important part of the SOAP structure is the exception mechanism that returns a Fault element in the response. The SOAP Fault is a stan...
The structure of Web site became more complex than before. During the design period of a Web site, the lack of model and method results in improper Web structure,which depend on the designer's experience. From the point of view of software engineering, every period in the software life must be evaluated before starting the next period's work. It is very important and essential to search relevant methods for evaluating Web structure before the site is completed. In this work, after studying the related work about the Web structure mining and analyzing the major structure mining methods (Page-rank and Hub/Authority), a method based on the Page-rank for Web structure evaluation in design stage is proposed. A Web structure modeling language WSML is designed, and the implement strategies for evaluating system of the Web site structure are given out. Web structure mining has being used mainly in search engines before. It is the first time to employ the Web structure mining technology to evaluate a Web structure in the design period of a Web site. It contributes to the formalization of the design documents for Web site and the improving of software engineering for large scale Web site, and the evaluating system is a practical tool for Web site construction.
Ray, Randy J
Given Perl's natural fit for web applications development, it's no surprise that Perl is also a natural choice for web services development. It's the most popular web programming language, with strong implementations of both SOAP and XML-RPC, the leading ways to distribute applications using web services. But books on web services focus on writing these applications in Java or Visual Basic, leaving Perl programmers with few resources to get them started. Programming Web Services with Perl changes that, bringing Perl users all the information they need to create web services using their favori
We focused on web services and their development. We presented two of the most common types of web services: SOAP and REST web services. We showed how they work, how to develop and ways how client can invoke them. Looking into SOAP web service details we described it's SOAP protocol and WSDL file for describing web service. We also described WS–* specifications and WS–I Basic Profile, which helps with interoperability. After describing SOAP web services, we described REST web services. Here w...
Hyeon Jin Park
Full Text Available The number of long-term survivors is increasing in the western countries due to remarkable improvements in the treatment of childhood cancer. The long-term complications of childhood cancer survivors in these countries were brought to light by the childhood cancer survivor studies. In Korea, the 5-year survival rate of childhood cancer patients is approaching 70%; therefore, it is extremely important to undertake similar long-term follow-up studies and comprehensive long-term care for our population. On the basis of the experiences of childhood cancer survivorship care of the western countries and the current Korean status of childhood cancer survivors, long-term follow-up study and long-term care systems need to be established in Korea in the near future. This system might contribute to the improvement of the quality of life of childhood cancer survivors through effective intervention strategies.
Dukes, M.; Gardi, E.; McAslan, H.; Scott, D. J.; White, C. D.
The non-Abelian exponentiation theorem has recently been generalised to correlators of multiple Wilson line operators. The perturbative expansions of these correlators exponentiate in terms of sets of diagrams called webs, which together give rise to colour factors corresponding to connected graphs. The colour and kinematic degrees of freedom of individual diagrams in a web are entangled by mixing matrices of purely combinatorial origin. In this paper we relate the combinatorial study of these matrices to properties of partially ordered sets (posets), and hence obtain explicit solutions for certain families of web-mixing matrix, at arbitrary order in perturbation theory. We also provide a general expression for the rank of a general class of mixing matrices, which governs the number of independent colour factors arising from such webs. Finally, we use the poset language to examine a previously conjectured sum rule for the columns of web-mixing matrices which governs the cancellation of the leading subdivergences between diagrams in the web. Our results, when combined with parallel developments in the evaluation of kinematic integrals, offer new insights into the all-order structure of infrared singularities in non-Abelian gauge theories.
Hoeber, Orland; Yang, Xue Dong
One of the fundamental goals of Web-based support systems is to promote and support human activities on the Web. The focus of this Chapter is on the specific activities associated with Web search, with special emphasis given to the use of visualization to enhance the cognitive abilities of Web searchers. An overview of information retrieval basics, along with a focus on Web search and the behaviour of Web searchers is provided. Information visualization is introduced as a means for supporting users as they perform their primary Web search tasks. Given the challenge of visualizing the primarily textual information present in Web search, a taxonomy of the information that is available to support these tasks is given. The specific challenges of representing search information are discussed, and a survey of the current state-of-the-art in visual Web search is introduced. This Chapter concludes with our vision for the future of Web search.
Ivers, Mary E.
Cancer survivor numbers in Ireland are increasing due to the success of modern treatments. Although most survivors have a good quality of life not all survivors return to \\'normal\\' after treatment. The HSE funded CANSURVIVOR research project has found that many survivors have difficulties and need help to recover and adjust after cancer treatment. Over a number of exploratory studies using interviews, focus groups and a survey of 262 breast, prostate, colorectal and lung cancer survivors, the researchers found that over 25% of survivors experienced significant difficulties with physical, emotional and social functioning, including symptoms such as insomnia and fatigue, while 33% experienced high levels of anxiety. Of particular concern were the findings that over 50% of survivors were overweight, 35% had reduced their physical activity levels and 13% continued to smoke after cancer, putting them at risk for further health problems. This evidence led to the development of an 8-week multi-disciplinary pilot rehabilitation programme. Significant quality of life improvements were achieved with increases in strength and fitness as well as a reduction in anxiety levels and dietary improvements. The researchers highlight the need for a structured, co-ordinated survivorship service, education of health professionals about survivorship and the provision of high quality information to survivors. This research was led by the School of Psychology at UCD in collaboration with the Physiotherapy and Nutrition departments of St. Vincent\\'s hospital.
Rains, Stephen A
Uncertainty management theory was applied in the present study to offer one theoretical explanation for how individuals use the World Wide Web to acquire health information and to help better understand the implications of the Web for information seeking. The diversity of information sources available on the Web and potential to exert some control over the depth and breadth of one's information-acquisition effort is argued to facilitate uncertainty management. A total of 538 respondents completed a questionnaire about their uncertainty related to cancer prevention and information-seeking behavior. Consistent with study predictions, use of the Web for information seeking interacted with respondents' desired level of uncertainty to predict their actual level of uncertainty about cancer prevention. The results offer evidence that respondents who used the Web to search for cancer information were better able than were respondents who did not seek information to achieve a level of uncertainty commensurate with the level of uncertainty they desired.
With the increased demand of complex, well-scalable and maintainable web applications, the MVC architecture is increasing in popularity and frameworks (whether they utilize the MVC architecture or not) are quickly becoming de facto –standard in web development. This Bachelor’s Thesis introduces the use of MVC architecture in web development and how several web application frameworks make use of it. This research introduces the concepts of both the MVC architecture and web ap...
Ringang, Rory R.; Cantero, Sean Michael A.; Toonen, Robert J.
We investigate the survivorship, growth and diet preferences of hatchery-raised juvenile urchins, Tripneustes gratilla, to evaluate the efficacy of their use as biocontrol agents in the efforts to reduce alien invasive algae. In flow-through tanks, we measured urchin growth rates, feeding rates and feeding preferences among diets of the most common invasive algae found in Kāneʻohe Bay, Hawaiʻi: Acanthophora spicifera, Gracilaria salicornia, Eucheuma denticulatum and Kappaphycus clade B. Post-transport survivorship of outplanted urchins was measured in paired open and closed cages in three different reef environments (lagoon, reef flat and reef slope) for a month. Survivorship in closed cages was highest on the reef flat (∼75%), and intermediate in the lagoon and reef slope (∼50%). In contrast, open cages showed similar survivorship on the reef flat and in the lagoon, but only 20% of juvenile urchins survived in open cages placed on the reef slope. Urchins grew significantly faster on diets of G. salicornia (1.58 mm/week ± 0.14 SE) and Kappaphycus clade B (1.69 ± 0.14 mm/wk) than on E. denticulatum (0.97 ± 0.14 mm/wk), with intermediate growth when fed on A. spicifera (1.23 ± 0.11 mm/wk). Interestingly, urchins display size-specific feeding preferences. In non-choice feeding trials, small urchins (17.5–22.5 mm test diameter) consumed G. salicornia fastest (6.08 g/day ± 0.19 SE), with A. spicifera (4.25 ± 0.02 g/day) and Kappaphycus clade B (3.83 ± 0.02 g/day) intermediate, and E. denticulatum was clearly the least consumed (2.32 ± 0.37 g/day). Medium-sized (29.8–43.8 mm) urchins likewise preferentially consumed G. salicornia (12.60 ± 0.08 g/day), with less clear differences among the other species in which E. denticulatum was still consumed least (9.35 ± 0.90 g/day). In contrast, large urchins (45.0–65.0 mm) showed no significant preferences among the different algae species at all (12.43–15.24 g/day). Overall consumption rates in non
Westbrook, Charley E; Ringang, Rory R; Cantero, Sean Michael A; Toonen, Robert J
We investigate the survivorship, growth and diet preferences of hatchery-raised juvenile urchins, Tripneustes gratilla, to evaluate the efficacy of their use as biocontrol agents in the efforts to reduce alien invasive algae. In flow-through tanks, we measured urchin growth rates, feeding rates and feeding preferences among diets of the most common invasive algae found in Kāne'ohe Bay, Hawai'i: Acanthophora spicifera, Gracilaria salicornia, Eucheuma denticulatum and Kappaphycus clade B. Post-transport survivorship of outplanted urchins was measured in paired open and closed cages in three different reef environments (lagoon, reef flat and reef slope) for a month. Survivorship in closed cages was highest on the reef flat (∼75%), and intermediate in the lagoon and reef slope (∼50%). In contrast, open cages showed similar survivorship on the reef flat and in the lagoon, but only 20% of juvenile urchins survived in open cages placed on the reef slope. Urchins grew significantly faster on diets of G. salicornia (1.58 mm/week ± 0.14 SE) and Kappaphycus clade B (1.69 ± 0.14 mm/wk) than on E. denticulatum (0.97 ± 0.14 mm/wk), with intermediate growth when fed on A. spicifera (1.23 ± 0.11 mm/wk). Interestingly, urchins display size-specific feeding preferences. In non-choice feeding trials, small urchins (17.5-22.5 mm test diameter) consumed G. salicornia fastest (6.08 g/day ± 0.19 SE), with A. spicifera (4.25 ± 0.02 g/day) and Kappaphycus clade B (3.83 ± 0.02 g/day) intermediate, and E. denticulatum was clearly the least consumed (2.32 ± 0.37 g/day). Medium-sized (29.8-43.8 mm) urchins likewise preferentially consumed G. salicornia (12.60 ± 0.08 g/day), with less clear differences among the other species in which E. denticulatum was still consumed least (9.35 ± 0.90 g/day). In contrast, large urchins (45.0-65.0 mm) showed no significant preferences among the different algae species at all (12.43-15.24 g/day). Overall consumption rates in non-choice trials
Charley E. Westbrook
Full Text Available We investigate the survivorship, growth and diet preferences of hatchery-raised juvenile urchins, Tripneustes gratilla, to evaluate the efficacy of their use as biocontrol agents in the efforts to reduce alien invasive algae. In flow-through tanks, we measured urchin growth rates, feeding rates and feeding preferences among diets of the most common invasive algae found in Kāneʻohe Bay, Hawaiʻi: Acanthophora spicifera, Gracilaria salicornia, Eucheuma denticulatum and Kappaphycus clade B. Post-transport survivorship of outplanted urchins was measured in paired open and closed cages in three different reef environments (lagoon, reef flat and reef slope for a month. Survivorship in closed cages was highest on the reef flat (∼75%, and intermediate in the lagoon and reef slope (∼50%. In contrast, open cages showed similar survivorship on the reef flat and in the lagoon, but only 20% of juvenile urchins survived in open cages placed on the reef slope. Urchins grew significantly faster on diets of G. salicornia (1.58 mm/week ± 0.14 SE and Kappaphycus clade B (1.69 ± 0.14 mm/wk than on E. denticulatum (0.97 ± 0.14 mm/wk, with intermediate growth when fed on A. spicifera (1.23 ± 0.11 mm/wk. Interestingly, urchins display size-specific feeding preferences. In non-choice feeding trials, small urchins (17.5–22.5 mm test diameter consumed G. salicornia fastest (6.08 g/day ± 0.19 SE, with A. spicifera (4.25 ± 0.02 g/day and Kappaphycus clade B (3.83 ± 0.02 g/day intermediate, and E. denticulatum was clearly the least consumed (2.32 ± 0.37 g/day. Medium-sized (29.8–43.8 mm urchins likewise preferentially consumed G. salicornia (12.60 ± 0.08 g/day, with less clear differences among the other species in which E. denticulatum was still consumed least (9.35 ± 0.90 g/day. In contrast, large urchins (45.0–65.0 mm showed no significant preferences among the different algae species at all (12.43–15.24 g/day. Overall consumption rates in non
Kâ, Samba; Carotenuto, Ylenia; Romano, Giovanna; Hwang, Jiang-Shiou; Buttino, Isabella; Ianora, Adrianna
Many diatoms, a major class of unicellular algae contributing to over 45% of oceanic primary production, are known to induce deleterious effects on reproductive processes in crustacean copepods. This is mainly due to the production of teratogenic oxylipins, including polyunsaturated aldehydes (PUAs). Here we tested the direct effect of the PUA 2E,4E-decadienal (DD) on feeding activity, survivorship and reproductive success of the calanoid copepod Temora stylifera. DD-inoculated cultures induced high mortality at concentrations above 3 μg mL(-1) compared to controls in both males and females, with males having a higher mortality. Low DD concentrations triggered an increase in female filtration and ingestion rates. Egg production rates and hatching times were also higher in the presence of DD, whereas egg hatching success decreased with increasing DD concentration. Our study shows, for the first time, that the presence of diatom PUAs may increase feeding rates in copepods.
Tang, Jiao; Busso, Carlos Alberto; Jiang, Deming; Musa, Ala; Wu, Dafu; Wang, Yongcui; Miao, Chunping
As a native tree species, Ulmus pumila var. sabulosa (sandy elm) is widely distributed in the Horqin Sandy Land, China. However, seedlings of this species have to withstand various depths of sand burial after emergence because of increasing soil degradation, which is mainly caused by overgrazing, climate change, and wind erosion. An experiment was conducted to evaluate the changes in its survivorship, morphological traits, and biomass allocation when seedlings were buried at different burial depths: unburied controls and seedlings buried vertically up to 33, 67, 100, or 133 % of their initial mean seedling height. The results showed that partial sand burial treatments (i.e., less than 67 % burial) did not reduce seedling survivorship, which still reached 100 %. However, seedling mortality increased when sand burial was equal to or greater than 100 %. In comparison with the control treatment, seedling height and stem diameter increased at least by 6 and 14 % with partial burial, respectively. In the meantime, seedling taproot length, total biomass, and relative mass growth rates were at least enhanced by 10, 15.6, and 27.6 %, respectively, with the partial sand burial treatment. Furthermore, sand burial decreased total leaf area and changed biomass allocation in seedlings, partitioning more biomass to aboveground organs (e.g., leaves) and less to belowground parts (roots). Complete sand burial after seedling emergence inhibited its re-emergence and growth, even leading to death. Our findings indicated that seedlings of sandy elm showed some resistance to partial sand burial and were adapted to sandy environments from an evolutionary perspective. The negative effect of excessive sand burial after seedling emergence might help in understanding failures in recruitments of sparse elm in the study region.
Maher, Jane; Radford, Gina
Jane Maher & Gina Radford speak to Gemma Westcott, Commissioning Editor Jane Maher has been Macmillan's Chief Medical Officer since 1999 and now shares the role as Joint Chief Medical Officer with general practitioner Rosie Loftus, reflecting the growing need for specialists and generalists to work more effectively together. She has been an National Health Service (NHS) improvement clinical leader for over 10 years and is a Consultant Clinical Oncologist at Mount Vernon Cancer Centre and Hillingdon Hospital where she has worked for more than 20 years, during which she helped develop nonsurgical oncology services in five district general hospitals. She is a senior Clinical Lecturer at University College London and Visiting Professor in Cancer and Supportive Care at the Centre for Complexity Management at the University of Hertfordshire. Jane chaired the Maher Committee for the Department of Health in 1995, led the UK National Audit of Late Effects Pelvic Radiotherapy for the Royal College of Radiologists (RCR) in 2000 and, most recently, chaired the National Cancer Survivorship Initiative Consequences of Treatment work stream. She co-founded one of the first Cancer Support and Information services in the UK, winning the Nye Bevan award in 1992 and there are now more than 60 units based on this model. She is a member of the Older People and Cancer Clinical Advisory Group. She has written more than 100 published articles and is a UK representative for cancer survivorship in Europe and advises on cancer survivorship programs in Denmark and Canada. Gina Radford is Deputy Chief Medical Officer for England, a post she took up in January 2015. Prior to that, she has held a number of roles in public health, at local and regional level. Most recently she was Centre Director for Anglia and Essex for Public Health England, and as a part of that role helped lead nationally on the public health response to Ebola. She was until very recently Chair of one of the NICE public health
Full Text Available In this era of digital tsunami of information on the web, everyone is completely dependent on the WWW for information retrieval. This has posed a challenging problem in extracting relevant data. Traditional web crawlers focus only on the surface web while the deep web keeps expanding behind the scene. The web databases are hidden behind the query interfaces. In this paper, we propose a Hidden Web Extractor (HWE that can automatically discover and download data from the Hidden Web databases. Since the only “entry point” to a Hidden Web site is a query interface, the main challenge that a Hidden WebExtractor has to face is how to automatically generate meaningful queries for the unlimited number of website pages.
Cetl, V.; Kliment, T.; Kliment, M.
The effective access and use of geospatial information (GI) resources acquires a critical value of importance in modern knowledge based society. Standard web services defined by Open Geospatial Consortium (OGC) are frequently used within the implementations of spatial data infrastructures (SDIs) to facilitate discovery and use of geospatial data. This data is stored in databases located in a layer, called the invisible web, thus are ignored by search engines. SDI uses a catalogue (discovery) service for the web as a gateway to the GI world through the metadata defined by ISO standards, which are structurally diverse to OGC metadata. Therefore, a crosswalk needs to be implemented to bridge the OGC resources discovered on mainstream web with those documented by metadata in an SDI to enrich its information extent. A public global wide and user friendly portal of OGC resources available on the web ensures and enhances the use of GI within a multidisciplinary context and bridges the geospatial web from the end-user perspective, thus opens its borders to everybody. Project "Crosswalking the layers of geospatial information resources to enable a borderless geospatial web" with the acronym BOLEGWEB is ongoing as a postdoctoral research project at the Faculty of Geodesy, University of Zagreb in Croatia (http://bolegweb.geof.unizg.hr/). The research leading to the results of the project has received funding from the European Union Seventh Framework Programme (FP7 2007-2013) under Marie Curie FP7-PEOPLE-2011-COFUND. The project started in the November 2014 and is planned to be finished by the end of 2016. This paper provides an overview of the project, research questions and methodology, so far achieved results and future steps.
Jonasen, Tanja Svarre; Ådland, Marit Kristine; Lykke, Marianne
The poster examines how web analytics can be used to provide information about users and inform design and redesign of taxonomies. It uses a case study of the website Cancer.dk by the Danish Cancer Society. The society is a private organization with an overall goal to prevent the development...... of cancer, improve patients’ chances of recovery, and limit the physical, psychological and social side-effects of cancer. The website is the main channel for communication and knowledge sharing with patients, their relatives and professionals. The present study consists of two independent analyses, one...... provides information about e.g. subjects of interest, searching behaviour, browsing patterns in website structure as well as tag clouds, page views. The poster discusses benefits and challenges of the two web metrics, with a model of how to use search and tag data for the design of taxonomies, e.g. choice...
Niriksha Bhojaraj Kabbin
Full Text Available Web applications in today’s world has a great impact on businesses and are popular since they provide business benefits and hugely deployable. Developing such efficient web applications using leading edge web technologies that promise to deliver upgraded user interface, greater scalability and interoperability, improved performance and usability, among different systems is a challenge. Google Web Toolkit (GWT is one such framework that helps to build Rich Internet Applications (RIAs that enable fertile development of high performance web applications. This paper puts an effort to provide an effective solution to develop quality web based applications with an added layer of security.
Thalheim, Bernhard; Prinz, Andreas; Buchberger, Bruno
The papers in this volume aim at obtaining a common understanding of the challenging research questions in web applications comprising web information systems, web services, and web interoperability; obtaining a common understanding of verification needs in web applications; achieving a common understanding of the available rigorous approaches to system development, and the cases in which they have succeeded; identifying how rigorous software engineering methods can be exploited to develop suitable web applications; and at developing a European-scale research agenda combining theory, methods a
Swallow, David; Petrie, Helen; Power, Christopher
This paper describes the design and evaluation of a Web Accessibility Information Resource (WebAIR) for supporting web developers to create and evaluate accessible websites. WebAIR was designed with web developers in mind, recognising their current working practices and acknowledging their existing understanding of web accessibility. We conducted an evaluation with 32 professional web developers in which they used either WebAIR or an existing accessibility information resource, the Web Content Accessibility Guidelines, to identify accessibility problems. The findings indicate that several design decisions made in relation to the language, organisation, and volume of WebAIR were effective in supporting web developers to undertake web accessibility evaluations.
Damani, Shamsha; Fulton, Stephanie
This article describes the experiences of librarians at the Research Medical Library embedded within clinical teams at The University of Texas MD Anderson Cancer Center and their efforts to enhance communication within their teams using Web 2.0 tools. Pros and cons of EndNote Web, Delicious, Connotea, PBWorks, and SharePoint are discussed.
Full Text Available This paper advocates a novel approach for mobile web browsing based on cooperation among wireless devices within close proximity operating in a cellular environment. In the actual state of the art, mobile phones can access the web using different cellular technologies. However, the supported data rates are not sufficient to cope with the ever increasing traffic requirements resulting from advanced and rich content services. Extending the state of the art, higher data rates can only be achieved by increasing complexity, cost, and energy consumption of mobile phones. In contrast to the linear extension of current technology, we propose a novel architecture where mobile phones are grouped together in clusters, using a short-range communication such as Bluetooth, sharing, and accumulating their cellular capacity. The accumulated data rate resulting from collaborative interactions over short-range links can then be used for cooperative mobile web browsing. By implementing the cooperative web browsing on commercial mobile phones, it will be shown that better performance is achieved in terms of increased data rate and therefore reduced access times, resulting in a significantly enhanced web browsing user experience on mobile phones.
K. F. Bharati
Full Text Available The traditional search engines available over the internet are dynamic in searching the relevant content over the web. The search engine has got some constraints like getting the data asked from a varied source, where the data relevancy is exceptional. The web crawlers are designed only to more towards a specific path of the web and are restricted in moving towards a different path as they are secured or at times restricted due to the apprehension of threats. It is possible to design a web crawler that will have the capability of penetrating through the paths of the web, not reachable by the traditional web crawlers, in order to get a better solution in terms of data, time and relevancy for the given search query. The paper makes use of a newer parser and indexer for coming out with a novel idea of web crawler and a framework to support it. The proposed web crawler is designed to attend Hyper Text Transfer Protocol Secure (HTTPS based websites and web pages that needs authentication to view and index. User has to fill a search form and his/her creditionals will be used by the web crawler to attend secure web server for authentication. Once it is indexed the secure web server will be inside the web crawler’s accessible zone
Svatek, Robert S; Rosenberg, Jonathan E; Galsky, Matthew D; Lee, Cheryl T; Latini, David M; Bochner, Bernard H; Weizer, Alon Z; Apolo, Andrea B; Sridhar, Srikala S; Kamat, Ashish M; Hansel, Donna; Flaig, Thomas W; Smith, Norm D; Lotan, Yair
The 6th Annual Bladder Cancer Think Tank brought together a multidisciplinary group of clinicians, researchers, and representatives from the National Cancer Institute and Industry in an effort to advance bladder cancer research efforts. This year's meeting comprised panel discussions and research involving 5 separate working groups, including the Survivorship, Clinical Trials, Standardization of Care, Data Mining, and Translational Science working groups. In this manuscript, the accomplishments and objectives of the working groups are summarized. Notable efforts include: (1) the development of a survivorship care plan for early and late-stage bladder cancer; (2) the development of consensus criteria for eligibility and endpoints for bladder cancer clinical trials; (3) an improved understanding of current practice patterns regarding the use of perioperative chemotherapy in an effort to standardize care; (4) creation of a comprehensive handbook to assist researchers with developing bladder cancer databases; and (5) identification of response to therapy of high-grade non muscle invasive disease through a collaborative exchange of expertise and resources.
Rubin, Philip; Constine, Louis S. [Univ. Rochester Medical Center, NY (United States). Dept. of Radiation Oncology; Marks, Lawrence B. (ed.) [Univ. North Carolina and Lineberger, Comprehensive Cancer Center, Chapel Hill, NC (United States). Dept. of Radiation Oncology
Comprehensively documents potential late effects in all the normal tissue sites in the human body. Considers in detail the detection, diagnosis, management and prevention of effects and discusses prognostic outcomes. Clearly presents radiation risk factors and interactions with chemotherapy effects. Provides the most current evidence-based medicine for cancer care survivorship guidelines. The literature on the late effects of cancer treatment is widely scattered in different journals since all major organ systems are affected and management is based on a variety of medical and surgical treatments. The aim of ALERT - Adverse Late Effects of Cancer Treatment is to offer a coherent multidisciplinary approach to the care of cancer survivors. The central paradigm is that cytotoxic multimodal therapy results in a perpetual cascade of events that affects each major organ system differently and is expressed continually over time. Essentially, radiation and chemotherapy are intense biologic modifiers that allow for cancer cure and cancer survivorship but accelerate senescence of normal tissues and increase the incidence of age-related diseases and second malignant tumors. Volume 2 of this two-volume work comprehensively documents potential late effects in all the normal tissue anatomic sites in the human body. The detection, diagnosis, management and prevention of effects are all considered in detail, and prognostic outcomes are discussed. Radiation risk factors and interactions with chemotherapy effects are clearly presented. The text is accompanied by numerous supportive illustrations and tables.
Presley, Carolyn J; Dotan, Efrat; Soto-Perez-de-Celis, Enrique; Jatoi, Aminah; Mohile, Supriya G; Won, Elizabeth; Alibhai, Shabbir; Kilari, Deepak; Harrison, Robert; Klepin, Heidi D; Wildes, Tanya M; Mustian, Karen; Demark-Wahnefried, Wendy
Nutritional issues among older adults with cancer are an understudied area of research despite significant prognostic implications for treatment side effects, cancer-specific mortality, and overall survival. In May of 2015, the National Cancer Institute and the National Institute on Aging co-sponsored a conference focused on future directions in geriatric oncology research. Nutritional research among older adults with cancer was highlighted as a major area of concern as most nutritional cancer research has been conducted among younger adults, with limited evidence to guide the care of nutritional issues among older adults with cancer. Cancer diagnoses among older adults are increasing, and the care of the older adult with cancer is complicated due to multimorbidity, heterogeneous functional status, polypharmacy, deficits in cognitive and mental health, and several other non-cancer factors. Due to this complexity, nutritional needs are dynamic, multifaceted, and dependent on the clinical scenario. This manuscript outlines the proceedings of this conference including knowledge gaps and recommendations for future nutritional research among older adults with cancer. Three common clinical scenarios encountered by oncologists include (1) weight loss during anti-cancer therapy, (2) malnutrition during advanced disease, and (3) obesity during survivorship. In this manuscript, we provide a brief overview of relevant cancer literature within these three areas, knowledge gaps that exist, and recommendations for future research.
Cautun, Marius; Jones, Bernard J T; Frenk, Carlos S
We investigate the characteristics and the time evolution of the cosmic web from redshift, z=2, to present time, within the framework of the NEXUS+ algorithm. This necessitates the introduction of new analysis tools optimally suited to describe the very intricate and hierarchical pattern that is the cosmic web. In particular, we characterize filaments (walls) in terms of their linear (surface) mass density. This is very good in capturing the evolution of these structures. At early times the cosmos is dominated by tenuous filaments and sheets, which, during subsequent evolution, merge together, such that the present day web is dominated by fewer, but much more massive, structures. We also show that voids are more naturally described in terms of their boundaries and not their centres. We illustrate this for void density profiles, which, when expressed as a function of the distance from void boundary, show a universal profile in good qualitative agreement with the theoretical shell-crossing framework of expandin...
Full Text Available The increasing availability and popularity of computer systems has resulted in a demand for new, language- and platform-independent ways of data exchange. That demand has in turn led to a significant growth in the importance of systems based on Web services. Alongside the growing number of systems accessible via Web services came the need for specialized data repositories that could offer effective means of searching of available services. The development of mobile systems and wireless data transmission technologies has allowed the use of distributed devices and computer systems on a greater scale. The accelerating growth of distributed systems might be a good reason to consider the development of distributed Web service repositories with built-in mechanisms for data migration and synchronization.
Learning system to study a discipline. In business to business interaction, different requirements and parameters of exchanged business requests might be served by different services from third parties. Such applications require certain intelligence and a slightly different approach to design. Adpative web...... adaptation to the changed parameters of environments, user or context. Adaptation can be seen as an orthogonal concern or viewpoint in a design process. In this paper I will discuss design abstractions which are employed in current design methods for web applications. I will exemplify the use......The unique characteristic of web applications is that they are supposed to be used by much bigger and diverse set of users and stakeholders. An example application area is e-Learning or business to business interaction. In eLearning environment, various users with different background use the e...
Expression Web is Microsoft's newest tool for creating and maintaining dynamic Web sites. This FrontPage replacement offers all the simple ""what-you-see-is-what-you-get"" tools for creating a Web site along with some pumped up new features for working with Cascading Style Sheets and other design options. Microsoft Expression Web For Dummies arrives in time for early adopters to get a feel for how to build an attractive Web site. Author Linda Hefferman teams up with longtime FrontPage For Dummies author Asha Dornfest to show the easy way for first-time Web designers, FrontPage ve
The emerging interdisciplinary study of Web-based support systems focuses on the theories, technologies and tools for the design and implementation of Web-based systems that support various human activities. This book presents the state-of-the-art in Web-based support systems (WSS). The research on WSS is multidisciplinary and focuses on supporting various human activities in different domains/fields based on computer science, information technology, and Web technology. The main goal is to take the opportunities of the Web, to meet the challenges of the Web, to extend the human physical limita
Full Text Available The effective access and use of geospatial information (GI resources acquires a critical value of importance in modern knowledge based society. Standard web services defined by Open Geospatial Consortium (OGC are frequently used within the implementations of spatial data infrastructures (SDIs to facilitate discovery and use of geospatial data. This data is stored in databases located in a layer, called the invisible web, thus are ignored by search engines. SDI uses a catalogue (discovery service for the web as a gateway to the GI world through the metadata defined by ISO standards, which are structurally diverse to OGC metadata. Therefore, a crosswalk needs to be implemented to bridge the OGC resources discovered on mainstream web with those documented by metadata in an SDI to enrich its information extent. A public global wide and user friendly portal of OGC resources available on the web ensures and enhances the use of GI within a multidisciplinary context and bridges the geospatial web from the end-user perspective, thus opens its borders to everybody. Project “Crosswalking the layers of geospatial information resources to enable a borderless geospatial web” with the acronym BOLEGWEB is ongoing as a postdoctoral research project at the Faculty of Geodesy, University of Zagreb in Croatia (http://bolegweb.geof.unizg.hr/. The research leading to the results of the project has received funding from the European Union Seventh Framework Programme (FP7 2007-2013 under Marie Curie FP7-PEOPLE-2011-COFUND. The project started in the November 2014 and is planned to be finished by the end of 2016. This paper provides an overview of the project, research questions and methodology, so far achieved results and future steps.
Hemel, Z.; Groenewegen, D.M.; Kats, L.C.L.; Visser, E.
Modern web application development frameworks provide web application developers with highlevel abstractions to improve their productivity. However, their support for static verification of applications is limited. Inconsistencies in an application are often not detected statically, but appear as er
Cancer nursing care across the UK has dramatically improved for children and young people with cancer over the past 20 years (Department of Health, 2007). Around 70% of young people diagnosed with cancer survive into adulthood, albeit with long-term health complications (Scottish Government, 2012). This raises the contemporary concern of how best to transition these patients to an adult-focused care regime (National Cancer Survivorship Initiative, 2012). With support from a Florence Nightingale Foundation Travel Scholarship in 2012, this study compared the various transition models currently in use across the UK, Finland and the USA with a clear focus on individual patient choice, staff education and preparation to care for this group of patients and their families. The findings revealed wide discrepancy in current nursing practices across the globe. This article presents a series of findings and recommendations to improve further the overall cancer experience for young people living with and beyond a cancer diagnosis.
This book is about the process of creating web-based systems (i.e., websites, content, etc.) that consider each of the parts, the modules, the organisms - binary or otherwise - that make up a balanced, sustainable web ecosystem. In the current media-rich environment, a website is more than a collection of relative html documents of text and images on a static desktop computer monitor. There is now an unlimited combination of screens, devices, platforms, browsers, locations, versions, users, and exabytes of data with which to interact. Written in a highly approachable, practical style, this boo
Every month, more than 130 billion queries worldwide are entered into the search boxes of general-purpose web search engines (ComScore, 2010). This enormous number shows that web searching is not only a large business, but also that many people rely on the search engines' results when researching information. A goal of all search engine evaluation efforts is to generate better systems. This goal is of major importance to the search engine vendors who can directly apply evaluation results to develop better ranking algorithms.
Sheth, A.; Henson, C.; Thirunarayan, K.
Sensors are distributed across the globe leading to an avalanche of data about our environment. It is possible today to utilize networks of sensors to detect and identify a multitude of observations, from simple phenomena to complex events and situations. The lack of integration and communication between these networks, however, often isolates important data streams and intensifies the existing problem of too much data and not enough knowledge. With a view to addressing this problem, the Semantic Sensor Web (SSW)  proposes that sensor data be annotated with semantic metadata that will both increase interoperability and provide contextual information essential for situational knowledge. Kno.e.sis Center's approach to SSW is an evolutionary one. It adds semantic annotations to the existing standard sensor languages of the Sensor Web Enablement (SWE) defined by OGC. These annotations enhance primarily syntactic XML-based descriptions in OGC's SWE languages with microformats, and W3C's Semantic Web languages- RDF and OWL. In association with semantic annotation and semantic web capabilities including ontologies and rules, SSW supports interoperability, analysis and reasoning over heterogeneous multi-modal sensor data. In this presentation, we will also demonstrate a mashup with support for complex spatio-temporal-thematic queries  and semantic analysis that utilize semantic annotations, multiple ontologies and rules. It uses existing services (e.g., GoogleMap) and semantics enhanced SWE's Sensor Observation Service (SOS) over weather and road condition data from various sensors that are part of Ohio's transportation network. Our upcoming plans are to demonstrate end to end (heterogeneous sensor to application) semantics support and study scalability of SSW involving thousands of sensors to about a billion triples. Keywords: Semantic Sensor Web, Spatiotemporal thematic queries, Semantic Web Enablement, Sensor Observation Service  Amit Sheth, Cory Henson, Satya
Maria Cristina ENACHE
Nash, David Richard
The world wide web provides many resources that are useful to the myrmecologist. Here I provide a brief introduc- tion to the types of information currently available, and to recent developments in data provision over the internet which are likely to become important resources for myrmecologists...... in the near future. I discuss the following types of web site, and give some of the most useful examples of each: taxonomy, identification and distribution; conservation; myrmecological literature; individual species sites; news and discussion; picture galleries; personal pages; portals....
Nash, David Richard
in the near future. I discuss the following types of web site, and give some of the most useful examples of each: taxonomy, identification and distribution; conservation; myrmecological literature; individual species sites; news and discussion; picture galleries; personal pages; portals.......The world wide web provides many resources that are useful to the myrmecologist. Here I provide a brief introduc- tion to the types of information currently available, and to recent developments in data provision over the internet which are likely to become important resources for myrmecologists...
Blåbjerg, Niels Jørgen
Learning Objects Web er et DEFF projekt som Aalborg Universitetsbibliotek har initieret. Projektet tager afsæt i de resultater og erfaringer som er opnået med vores tidligere projekt Streaming Webbased Information Modules (SWIM). Vi har et internationalt netværk af interessenter som giver os...... sparring og feedback i forhold til udviklingskoncept både omkring de teoretiske rammer og i forhold til praktisk anvendelse af vores undervisningskoncept. Med disse rygstød og input har vi forfulgt ønsket om at videreudvikle SWIM i det nye projekt Learning Objects Web. Udgivelsesdato: juni...
How do you create a mission-critical site that provides exceptional performance while remaining flexible, adaptable, and reliable 24/7? Written by the manager of a UI group at Yahoo!, Developing Large Web Applications offers practical steps for building rock-solid applications that remain effective even as you add features, functions, and users. You'll learn how to develop large web applications with the extreme precision required for other types of software. Avoid common coding and maintenance headaches as small websites add more pages, more code, and more programmersGet comprehensive soluti
With a number of cheap commercial dry EEG kits available today, it is possible to look at user attention driven scenarios for interaction with the web browser. Using EEG to determine the user's attention level is preferable to using methods such as gaze tracking or time spent on the webpage. In this paper we use the attention level in three different ways. First, as a control mechanism, to control user interface elements such as menus or buttons. Second, to make the web browser responsive to ...
Web engineering is the establishment and use of sound scientific,engineering and management principlesand disciplined and systematic approaches to the successful development ,deployment and maintenance of high qualityWeb-based systems and applications. This paper presents the history of WebE and its relationship with software engi-neering,furthermore ,we give the popular Web development process and the areas of further study.
Groenewegen, D.M.; Visser, E.
This paper is a pre-print of: Danny M. Groenewegen, and Eelco Visser. Weaving Web Applications with WebDSL (Demonstration). In: Gary T. Leavens (editor) Companion to the 24th ACM SIGPLAN Conference on Object-Oriented Programing, Systems, Languages, and Applications (OOPSLA 2009). WebDSL is a domain
Espinha, T.; Zaidman, A.; Gross, H.G.
Web APIs provide a systematic and extensible approach for application-to-application interaction. A large number of mobile applications makes use of web APIs to integrate services into apps. Each Web API’s evolution pace is determined by their respective developer and mobile application developers a
Kothari, Bhupesh; Claypool, Mark
Discussion of Web servers and requests for dynamic pages focuses on experimentally measuring and analyzing the performance of the three dynamic Web page generation technologies: CGI, FastCGI, and Servlets. Develops a multivariate linear regression model and predicts Web server performance under some typical dynamic requests. (Author/LRW)
Li, Hui; Rau, Pei-Luen Patrick; Fujimura, Kaori; Gao, Qin; Wang, Lin
This research aims to provide insight for web form design for older users. The effects of task complexity and information structure of web forms on older users' performance were examined. Forty-eight older participants with abundant computer and web experience were recruited. The results showed significant differences in task time and error rate…
Garcia, Joseph A.; Smith, Charles A. (Technical Monitor)
The document consists of a publicly available web site (george.arc.nasa.gov) for Joseph A. Garcia's personal web pages in the AI division. Only general information will be posted and no technical material. All the information is unclassified.
Compares the attributes of the silk from spiders with those of the commercially harvested silk from silkworms. Discusses the evolution, design, and effectiveness of spider webs; the functional mechanics of the varieties of silk that can be produced by the same spider; and the composite, as well as molecular, structure of spider silk thread. (JJK)
A delicate pattern, like that of a spider web, appears on top of the Mars residual polar cap, after the seasonal carbon-dioxide ice slab has disappeared. Next spring, these will likely mark the sites of vents when the carbon-dioxide ice cap returns. This Mars Global Surveyor, Mars Orbiter Camera image is about 3-kilometers wide (2-miles).
Progressive Web Applications are native-like applications running inside of a browser context. In my presentation I would like describe their characteristics, benchmarks and building process using a quick and simple case study example with focus on Service Workers api.
Graham, J. [American Nuclear Society (United States)
This paper notes the ineffectualness of organizational World Wide Web sites which are generally supportive of nuclear science and technology versus those whose mission is to oppose nuclear matters and which do so by providing mis-information to the public. Specific comparisons of pro and con sites are made, and recommendations are made for improving the communication effectiveness of proponent sites. (author)
Zaretzki, J.; Bergeron, C.; Huang, T.-W.;
. RS-WebPredictor is the first freely accessible server that predicts the regioselectivity of the last six isozymes. Server execution time is fast, taking on average 2s to encode a submitted molecule and 1s to apply a given model, allowing for high-throughput use in lead optimization projects...
Web 2．0是现在媒体上常见的名词,但究竟什么是Web 2．0?这个术语的始作俑者蒂姆·欧内利是这样定义的:“Web 2．0指网络作为平台,横跨所有互联设备;Web 2．0应用充分调动这一平台的内在优势:把软件作为不断升级的服务加以提供,使用软件的人越多,软件变得越好;这些应用从多种来源(包括个人用户)吸取和重混数据,与此同时,允许自己的数据和服务被他人重混。”这个定义由于技术化而显得晦涩难解。在另一处,欧内利举例
Tjin-Kam-Jet, Kien-Tsoi Theodorus Egbert
The World Wide Web contains billions of documents (and counting); hence, it is likely that some document will contain the answer or content you are searching for. While major search engines like Bing and Google often manage to return relevant results to your query, there are plenty of situations in
In this thesis, we investigate the path towards a focused web harvesting approach which can automatically and efficiently query websites, navigate through results, download data, store it and track data changes over time. Such an approach can also facilitate users to access a complete collection of
In this article, the author presents Web sites about teen use of online social networks and age-appropriate resources. These resources can be used for teaching students ways in which to use these networks safely and ethically. Among other things, "Social Network Service" entry in Wikipedia, offers a description and a "List of Social Networking…
Presents a method to connect VRML (Virtual Reality Modeling Language) and Java components in a Web page using EAI (External Authoring Interface), which makes it possible to interactively generate and edit VRML meshes. The meshes used are based on regular grids, to provide an interaction and modeling
Baken, N.H.G.; Wiegel, V.; Van Oortmerssen, G.
This paper presents a vision on the importance of values and ethical aspects in web science. We create(d) the Internet, but now the Internet (technology) is shaping our world increasingly: the way we experience, interact, transact, conduct business et cetera. The Internet is ubiquitous and vital to
Alexandru Dan CĂPRIŢĂ
Full Text Available Unit tests are a vital part of several software development practicesand processes such as Test-First Programming, Extreme Programming andTest-Driven Development. This article shortly presents the software quality andtesting concepts as well as an introduction to an automated unit testingframework for PHP web based applications.
Documentaire court qui retrace l'implication de différentes personalités à la création du Web. Entrevues avec Robert Cailliau, Chris Llewellyn-Smith, David Williams, Tim Berners-Lee, Mike Sendall, Brian Carpenter.
The Internet has the potential to be the ultimate information resource, but it needs to be organized in order to be useful. This paper discusses how the subject guide, "Yahoo!" is different from most web search engines, and how best to search for information on Yahoo! The strength in Yahoo! lies in the subject hierarchy. Advantages to…
This book is for anyone who's worked with Clojure and wants to use it to start developing applications for the Web. Experience or familiarity with basic Clojure syntax is a must, and exposure to Leiningen (or other similar build tools such as Maven) would be helpful.
Discusses the increase in online plagiarism and what school librarians can do to help. Topics include the need for school district policies on plagiarism; teaching students what plagiarism is; pertinent Web sites; teaching students proper research skills; motivation for cheating; and requiring traditional sources of information for student…
Cambronero, M.-Emilia; Okika, Joseph C.; Ravn, Anders Peter
Web services should be dependable, because businesses rely on them. For that purpose the Service Oriented Architecture has standardized specifications at a syntactical level. In this paper, we demonstrate how such specifications are used to derive semantic models in the form of (timed) automata...
Web Archives of ATLAS Plenary Sessions, Workshops, Meetings, and Tutorials recorded over the past two years are available via the University of Michigan portal here. Most recent additions include the ROOT Workshop held at CERN on March 26-27, the Physics Analysis Tools Workshop held in Bergen, Norway on April 23-27, and the CTEQ Workshop: "Physics at the LHC: Early Challenges" held at Michigan State University on May 14-15. Viewing requires a standard web browser with RealPlayer plug-in (included in most browsers automatically) and works on any major platform. Lectures can be viewed directly over the web or downloaded locally. In addition, you will find access to a variety of general tutorials and events via the portal. Suggestions for events or tutorials to record in 2007, as well as feedback on existing archives is always welcome. Please contact us at firstname.lastname@example.org. Thank you and enjoy the lectures! The Michigan Web Lecture Team Tushar Bhatnagar, Steven Goldfarb, Jeremy Herr, Mitch McLachlan, Homer A....
A hands-on focused step-by-step tutorial to help you create Web Service applications using Dropwizard. If you are a software engineer or a web developer and want to learn more about building your own Web Service application, then this is the book for you. Basic knowledge of Java and RESTful Web Service concepts is assumed and familiarity with SQL/MySQL and command-line scripting would be helpful.
Lewandowski, Dirk; Mayr, Philipp
Purpose: To provide a critical review of Bergman’s 2001 study on the Deep Web. In addition, we bring a new concept into the discussion, the Academic Invisible Web (AIW). We define the Academic Invisible Web as consisting of all databases and collections relevant to academia but not searchable by the general-purpose internet search engines. Indexing this part of the Invisible Web is central to scientific search engines. We provide an overview of approaches followed thus far. Design/methodol...
US Agency for International Development — WebPass Explorer (WebPASS Framework): USAID is partnering with DoS in the implementation of their WebPass Post Personnel (PS) Module. WebPassPS does not replace...
US Agency for International Development — WebPass Explorer (WebPASS Framework): USAID is partnering with DoS in the implementation of their WebPass Post Personnel (PS) Module. WebPassPS does not replace...
McGinley, Kathleen F; Tay, Kae Jack; Moul, Judd W
Men of African origin are disproportionately affected by prostate cancer: prostate cancer incidence is highest among men of African origin in the USA, prostate cancer mortality is highest among men of African origin in the Caribbean, and tumour stage and grade at diagnosis are highest among men in sub-Saharan Africa. Socioeconomic, educational, cultural, and genetic factors, as well as variations in care delivery and treatment selection, contribute to this cancer disparity. Emerging data on single-nucleotide-polymorphism patterns, epigenetic changes, and variations in fusion-gene products among men of African origin add to the understanding of genetic differences underlying this disease. On the diagnosis of prostate cancer, when all treatment options are available, men of African origin are more likely to choose radiation therapy or to receive no definitive treatment than white men. Among men of African origin undergoing surgery, increased rates of biochemical recurrence have been identified. Understanding differences in the cancer-survivorship experience and quality-of-life outcomes among men of African origin are critical to appropriately counsel patients and improve cultural sensitivity. Efforts to curtail prostate cancer screening will likely affect men of African origin disproportionately and widen the racial disparity of disease.
Full Text Available Document coherency is a challenging problem for Web caching. Once the documents are cached throughout the Internet, it is often difficult to keep them coherent with the origin document without generating a new traffic that could increase the traffic on the international backbone and overload the popular servers. Several solutions have been proposed to solve this problem, among them two categories have been widely discussed: the strong document coherency and the weak document coherency. The cost and the efficiency of the two categories are still a controversial issue, while in some studies the strong coherency is far too expensive to be used in the Web context, in other studies it could be maintained at a low cost. The accuracy of these analysis is depending very much on how the document updating process is approximated. In this study, we compare some of the coherence methods proposed for Web caching. Among other points, we study the side effects of these methods on the Internet traffic. The ultimate goal is to study the cache behavior under several conditions, which will cover some of the factors that play an important role in the Web cache performance evaluation and quantify their impact on the simulation accuracy. The results presented in this study show indeed some differences in the outcome of the simulation of a Web cache depending on the workload being used, and the probability distribution used to approximate updates on the cached documents. Each experiment shows two case studies that outline the impact of the considered parameter on the performance of the cache.
... page: //medlineplus.gov/ency/article/002844.htm Funnel-web spider bite To use the sharing features on this ... effects of a bite from the funnel-web spider. Male funnel-web spiders are more poisonous than females. This article ...
Discusses Web browsers and how their capabilities have been expanded, support for Web browsing on different devices (cell phones, palmtop computers, TV sets), and browser support for the next-generation Web authoring language, XML ("extensible markup language"). (Author/VWL)
Explores the interrelation between Web publishing and information retrieval technologies and lists new approaches to Web indexing and searching. Highlights include Web directories; search engines; portalisation; Internet service providers; browser providers; meta search engines; popularity based analysis; natural language searching; links-based…
Salsovic, Annette R.
A WebQuest is an inquiry-based lesson plan that uses the Internet. This article explains what a WebQuest is, shows how to create one, and provides an example. When engaged in a WebQuest, students use technology to experience cooperative learning and discovery learning while honing their research, writing, and presentation skills. It has been found…
Ramaprasad, Arkalgud; Kashyap, Vipul
The semiotic web for translational medicine generalizes the concept of the semantic web. We present the functions of the semiotic web as a simple ontology with three dimensions, namely: (a) the four steps of semiotics, (b) the two processes in semiotics, and (c) the four types of research. The resulting 32 combinations represent all its functions.
Modern Web sites have evolved from simple monolithic systems to complex multitiered systems. In contrast to traditional Web sites, these sites do not simply deliver pre-written content but dynamically generate content using (one or more) multi-tiered Web applications. In this thesis, we addresse
The essential components to building a successful Web site are many times overlooked. There is a misconception that if an individual knows HTML or is a Web developer, an effective Web site can easily be created. In reality, a variety of other factors are needed before technical skills ever come into play. When instructing students in the art of…
The semantic web or Web 3.0 makes information more meaningful to people by making it more understandable to machines. In this article, the author examines the implications of Web 3.0 for education. The author considers three areas of impact: knowledge construction, personal learning network maintenance, and personal educational administration.…
Following pages will be about abounded term "Web 2.0". I will try to explain the core characteristics of "Web 2.0" applications. This explanation will be followed by some existing examples of these applications. Main target is to explain the term "Web 2.0".
近年来Web服务领域发生着翻天覆地的变化,继传统的XML-RPC风格的Web Service之后,一种新的风格,REST被应用于Web Service.本文主要介绍了Rest构架风格,以及现在Java开发Restful Web Service的主要方式,以及如何实现Restful Web Service的Java和Ajax客户端,最后介绍了Restful Web Service的描述语言WADL.
LIU Mao-fu; HE Jing; HE Yan-xiang; HU Hui-jun
We combine the web usage mining and fuzzy clustering and give the concept of web fuzzy clustering, and then put forward the web fuzzy clustering processing model which is discussed in detail. Web fuzzy clustering can be used in the web users clustering and web pages clustering. In the end, a case study is given and the result has proved the feasibility of using web fuzzy clustering in web pages clustering.
Full Text Available Objective: Treatment for oral tongue cancer poses unique challenges to restoring and maintaining personally acceptable, intelligible speech. Methods: We report how oral tongue cancer survivors describe their speech after treatment in a qualitative descriptive approach using constant comparative technique to complete a focal analysis of interview data from a larger grounded theory study of oral tongue cancer survivorship. Interviews were completed with 16 tongue cancer survivors 3 months to 12 years postdiagnosis with stage I-IV disease and treated with surgery alone, surgery and radiotherapy, or chemo-radiation. All interview data from the main study were analyzed for themes describing perceptions of speech as oral tongue cancer survivors. Results: Actual speech impairments varied among survivors. None experienced severe impairments that inhibited their daily lives. However, all expressed some level of concern about speech. Concerns about altered speech began when survivors heard their treatment plans and continued through to survivorship without being fully resolved. The overarching theme, maintaining a pattern and character of speech acceptable to the survivor, was termed "speaking legibly" using one survivor′s vivid in vivo statement. Speaking legibly integrate the sub-themes of "fears of sounding unusual," "learning to talk again," "problems and adjustments," and "social impact." Conclusions: Clinical and scientific efforts to further understand and address concerns about speech, personal presentation, and identity among those diagnosed with oral tongue are important to improving care processes and patient-centered experience.
Hagan, Teresa L; Medberry, Elizabeth
A growing emphasis on patient self-advocacy has emerged in the public discourse on cancer survivorship. This discourse shapes patients' conceptualizations about self-advocacy and in turn influences their health care attitudes and behaviors. The purpose of this discourse analysis is to explore the language of self-advocacy by comparing a published self-advocacy guide with the lived experiences of women with ovarian cancer. Data sources include (1) a self-advocacy patient education guide published by the National Coalition for Cancer Survivorship and (2) transcripts of focus groups conducted with ovarian cancer survivors. Discourse analysis techniques were used to take a close look at the language used by both to uncover the meaning each group ascribed to self-advocacy. Challenges and inconsistencies were noted between the patient education guide and transcripts including viewing self-advocacy as a skill set to assert one's needs as opposed to a means by which to preserve a positive attitude and maintain a trusting relationship with health care providers, respectively. Some women saw themselves as self-advocates yet struggled to locate relevant health information and hesitated to upset their relationship with their health care providers. This analysis highlights tensions between the discourses and points to ways in which patient education materials can be adjusted to support cancer survivors in advocating for their needs according to their unique situations and preferences.
Francisco O. Martínez P.
Full Text Available Restrictions regardingnavigability and user-friendliness are the main challenges the Mobile Web faces to be accepted worldwide. W3C has recently developed the Mobile Web Initiative (MWI, a set of directives for the suitable design and presentation of mobile Web interfaces. This article presents the main features and functional modules of OneWeb, an MWI-based Web content adaptation platform developed by Mobile Devices Applications Development Interest Group’s (W@PColombia research activities, forming part of the Universidad de Cauca’s Telematics Engineering Group.Some performance measurementresults and comparison with other Web content adaptation platforms are presented. Tests have shown suitable response times for Mobile Web environments; MWI guidelines were applied to over twenty Web pages selected for testing purposes.
Full Text Available The accessibility of public administration web sites is a key quality attribute for the successful implementation of the Information Society. The purpose of this paper is to present a second review of municipal web sites in Romania that is based on automated accessibility checking. A number of 60 web sites were evaluated against WCAG 2.0 recommendations. The analysis of results reveals a relatively low web accessibility of municipal web sites and highlights several aspects. Firstly, a slight progress in web accessibility was noticed as regarded the sample evaluated in 2010. Secondly, the number of specific accessibility errors is varying across the web sites and the accessibility is not preserved in time. Thirdly, these variations suggest that an accessibility check before launching a new release for a web page is not a common practice.
Thomsen, Jakob; Ernst, Erik; Brabrand, Claus
We present, WebSelF, a framework for web scraping which models the process of web scraping and decomposes it into four conceptually independent, reusable, and composable constituents. We have validated our framework through a full parameterized implementation that is flexible enough to capture...... previous work on web scraping. We have experimentally evaluated our framework and implementation in an experiment that evaluated several qualitatively different web scraping constituents (including previous work and combinations hereof) on about 11,000 HTML pages on daily versions of 17 web sites over...... a period of more than one year. Our framework solves three concrete problems with current web scraping and our experimental results indicate that com- position of previous and our new techniques achieve a higher degree of accuracy, precision and specificity than existing techniques alone....
Korgaonkar, Pradeep; Wolin, Lori D.
Discusses Web sales and explores the differences between heavy, medium, and light Web users in terms of their beliefs about Web advertising, attitudes toward Web advertising, purchasing patterns, and demographics. Suggests marketers need to target Web advertising to particular Web users. (Author/LRW)
22 K. WEB SERVICES CHOREOGRAPHY DESCRIPTION LANGUAGE (WS-CDL...Intelligent Framework WSBPEL Web Services Business Process Execution Language WS-CDL Web Services Choreography Description Language WSDL Web...Language (WSBPEL) is a related technology addressing service orchestration. Web Services Choreography and Web Services Security are important areas
Web Dynpro ABAP, a NetWeaver web application user interface tool from SAP, enables web programming connected to SAP Systems. The authors' main focus was to create a book based on their own practical experience. Each chapter includes examples which lead through the content step-by-step and enable the reader to gradually explore and grasp the Web Dynpro ABAP process. The authors explain in particular how to design Web Dynpro components, the data binding and interface methods, and the view controller methods. They also describe the other SAP NetWeaver Elements (ABAP Dictionary, Authorization) and
近年来Web服务领域发生着翻天覆地的变化,继传统的XML-RPC风格的Web Service之后,一种新的风格,REST被应用于Web Service.本文主要介绍了Rest构架风格,以及现在Java开发Restful Web Service的主要方式,以及如何实现Restful Web Service的Java和Ajax客户端,最后介绍了Restful Web Service的描述语言WADL.
近年来Web服务领域发生着翻天覆地的变化，继传统的XML-RPC风格的Web Service之后，一种新的风格，REST被应用于WebService。本文主要介绍了Rest构架风格，以及现在Java开发Restful Web Service的主要方式，以及如何实现Resfful Web Service的Java和Ajax客户端，最后介绍了Restful Web Service的描述语言WADL。
What is a web app? It's software that you use right in your web browser. Rather than installing an application on your computer, you visit a web site and sign up as a new user of its software. Instead of storing your files on your own hard disk, the web app stores them for you, online. Is it possible to switch entirely to web apps? To run nothing but a browser for an entire day? In this PDF we'll take you through one day in the life of a web apps-only user and chronicle the pros and cons of living by browser. And if the idea of switching, fully or partially, to web apps sounds appealing to
CGH’s Dr. Sudha Sivaram, Dr. Makeda Williams, and Ms. Kalina Duncan have partnered with Drs. Ami Bhatt and Franklin Huang at Global Oncology, Inc. (GO) to develop the Global Cancer Project Map - a web-based tool designed to facilitate cancer research and control activity planning.
Guoqing Zhang; Yunsheng Zhang; Yunchao Ling; Jia Jia
Pharmacogenomics is the study of the impact of genetic variations or genotypes of individuals on their drug response or drug metabolism. Compared to traditional genomics research, pharmacogenomic research is more closely related to clinical practice. Pharmacogenomic discoveries may effectively assist clinicians and healthcare providers in determining the right drugs and proper dose for each patient, which can help avoid side effects or adverse reactions, and improve the drug therapy. Currently, pharmacogenomic approaches have proven their utility when it comes to the use of cardiovascular drugs, antineoplastic drugs, aromatase inhibitors, and agents used for infectious diseases. The rapid innovation in sequencing technology and genome-wide association studies has led to the development of numerous data resources and dramatically chan-ged the landscape of pharmacogenomic research. Here we describe some of these web resources along with their names, web links, main contents, and our ratings.
Zhang, Guoqing; Zhang, Yunsheng; Ling, Yunchao; Jia, Jia
Pharmacogenomics is the study of the impact of genetic variations or genotypes of individuals on their drug response or drug metabolism. Compared to traditional genomics research, pharmacogenomic research is more closely related to clinical practice. Pharmacogenomic discoveries may effectively assist clinicians and healthcare providers in determining the right drugs and proper dose for each patient, which can help avoid side effects or adverse reactions, and improve the drug therapy. Currently, pharmacogenomic approaches have proven their utility when it comes to the use of cardiovascular drugs, antineoplastic drugs, aromatase inhibitors, and agents used for infectious diseases. The rapid innovation in sequencing technology and genome-wide association studies has led to the development of numerous data resources and dramatically changed the landscape of pharmacogenomic research. Here we describe some of these web resources along with their names, web links, main contents, and our ratings.
A Note from the Author and from O'Reilly Media about what this bookdoes--and doesn't--do: Palm webOS is a brand new platform and represents a very different type ofoperating system where the web runtime is used as the basis for the UI andApplication model. Palm and O'Reilly felt that it was important to have abook available to help developers get a basic understanding of the new Palmplatform at the time that the SDK was released; this timing played a majorrole in the content and structure of the book. Ideally this book would have been a complete reference of the new platformbut that wasn't
In an effort to increase the strength of AGU by increasing participation in voting, you will be able to cast your ballot for AGU officers on the Web this year. The Tellers Committee is working with an experienced firm, election.com, to develop procedures for conducting AGU's first electronic election in November and December 2001. You will be able to cast your votes for the officers of your choice, among the 62 candidates, by going to a secure Web site, or by requesting a paper ballot.An amendment to the District of Columbia law now permits non-profit organizations incorporated in Washington, D.C. to conduct elections using electronic voting. AGU was instrumental in getting the amendment adopted by the Council of the District of Columbia in spring 2001.
Perrucci, GP; Fitzek, FHP; Zhang, Qi
This paper advocates a novel approach for mobile web browsing based on cooperation among wireless devices within close proximity operating in a cellular environment. In the actual state of the art, mobile phones can access the web using different cellular technologies. However, the supported data...... extension of current technology, we propose a novel architecture where mobile phones are grouped together in clusters, using a short-range communication such as Bluetooth, sharing, and accumulating their cellular capacity. The accumulated data rate resulting from collaborative interactions over short...... rates are not sufficient to cope with the ever increasing trafic requirements resulting from advanced and rich content services. Extending the state of the art, higher data rates can only be achieved by increasing complexity, cost, and energy consumption of mobile phones. In contrast to the linear...
Fuhry, Benny; Tighzert, Walter; Kerschbaum. Florian
The software-as-a-service (SaaS) market is growing very fast, but still many clients are concerned about the confidentiality of their data in the cloud. Motivated hackers or malicious insiders could try to steal the clients’ data. Encryption is a potential solution, but supporting the necessary functionality also in existing applications is difficult. In this paper, we examine encrypting analytical web applications that perform extensive number processing operations in the database. Existing ...
Kuntal B. Adak
Full Text Available In this paper we present a web camera based touchscreen system which uses a simple technique to detect and locate finger. We have used a camera and regular screen to achieve our goal. By capturing the video and calculating position of finger on the screen, we can determine the touch position and do some function on that location. Our method is very easy and simple to implement. Even our system requirement is less expensive compare to other techniques.
This research, part of the ongoing study to better understand Web page ranking on the Web, looks at a Web page as a graph structure or Web graph, and classifies different Web graphs in the new coordinate space (out-degree, in-degree). Google's Web ranking algorithm (Brin & Page, 1998) on ranking Web pages is applied in this new coordinate…
Marylene S. Eder
Full Text Available Abstract Interactive campus map is a web based application that can be accessed through a web browser. With the Google Map Application Programming Interface availability of the overlay function has been taken advantage to create custom map functionalities. Collection of building points were gathered for routing and to create polygons which serves as a representation of each building. The previous campus map provides a static visual representation of the campus. It uses legends building name and its corresponding building number in providing information. Due to its limited capabilities it became a realization to the researchers to create an interactive campus map.Storing data about the building room and staff information and university events and campus guide are among the primary features that this study has to offer. Interactive Web-based Campus Information System is intended in providing a Campus Information System.It is open to constant updates user-friendly for both trained and untrained users and capable of responding to all needs of users and carrying out analyses. Based on the data gathered through questionnaires researchers analyzed the results of the test survey and proved that the system is user friendly deliver information to users and the important features that the students expect.
Computer Security Team
You’re about to launch a new website? Cool!! With today’s web programming languages like PHP, Java, Python or Perl, complex websites can be created, easily fulfilling all your use cases. But hold on. Did you ever think about how easily this can be abused? Attackers today are already using automatic tools which can quickly and easily find and exploit vulnerable web applications. Web applications often suffer from security vulnerabilities, i.e. design flaws or programming bugs that remained undetected during the whole software development cycle. In production these vulnerabilities become security holes, providing an opportunity for exploitation, and can pose immense security risks (and there is no reason to believe that CERN is immune to this). The costs associated with eliminating these bugs could be loosely described by the "1:10:100 rule", i.e. the relative costs for fixing are 1:10:100 for fixing them in the programming:testing:production phases. Thus, the...
Full Text Available Ekybion is a drug complex of 16 natural extracts and inorganic compounds designed to treat a variety of respiratory pathogens of bacterial and viral origin. It is licensed throughout Europe for the treatment of respiratory tract infections from equine parainfluenza type 3 and equine herpes virus type 1 in equine stables. The purpose of this paper was to test the efficacy of Ekybion on a well-developed animal model of influenza A infection and determine a mode of action. Experiments were performed with Balb/c mice infected with a lethal dose of influenza A/PR/8/34 H1N1 virus and treated with nebulized Ekybion every 8 h in a time-dependant or dose-dependant fashion. These experiments showed that mice treated prior to infection with Ekybion had a higher survival rates (~46% compared with untreated animals (~0%. Paradoxically, these mice showed no significant difference in lung virus titer or weight loss. There was, however, a decrease in the level of GM-CSF, IL-6, and G-CSF cytokines in the lungs of Ekybion-treated, infected mice. It is possible that decreases in proinflammatory cytokines may have contributed to increased survivorship in Ekybion-treated influenza-infected mice.
Full Text Available Purpose. This study examined whether octogenarians and elderly patients with pelvic fractures have a different risk of complication and mortality as compared to adults. Methods. Data was gathered from the National Trauma Data Bank from 2002 to 2006. There were 32,660 patients 18–65, 6,408 patients 65–79, and 5,647 patients ≥ 80 years old with pelvic fractures. Descriptive statistics and bivariate and multivariate analyses were performed with the adult population as a referent. Results. Multivariate analysis showed 4.7-fold higher odds of death and 4.57 odds of complications in the octogenarian group after a pelvic fracture compared to adults. The elderly had 1.81-fold higher odds of death and 2.18-fold higher odds of severe complications after sustaining a severe pelvic fracture relative to adults. An ISS ≥ 16 yielded 15.1-fold increased odds of mortality and 18.3-fold higher odds of severe complications. Hypovolemic shock had 7.65-fold increased odds of death and 6.31-fold higher odds of severe complications. Between the ages of 18 and 89 years, there is approximately a 1% decrease in survivorship every 10 years. Conclusions. This study illustrates that patients older than 80 years old with pelvis fractures have a higher mortality and complications rate than elderly or adult patients.
Blanch-Hartigan, Danielle; Viswanath, Kasisomayajula
With 14 million cancer survivors in the United States, identifying and categorizing their use of sources of cancer-related information is vital for targeting effective communications to this growing population. In addition, recognizing socioeconomic and sociodemographic differences in the use of cancer-related information sources is a potential mechanism for reducing health disparities in survivorship. Fourteen sources of information survivors (N = 519) used for cancer-related information were factor-analyzed to create a taxonomy of source use. The association between social determinants and use of these source types was analyzed in regression models. Factor analysis revealed 5 categories of information source use (mass media; Internet and print; support organizations; family and friends; health care providers), and use varied based on sociodemographic and socioeconomic characteristics. Higher education predicted increased use of all source categories except mass media. African American cancer survivors turned to health care providers as a source for cancer-related information less often than did White survivors. Social determinants predicted differences in the type of cancer-related information sources used. Providers and health communicators should target communication platforms based on the demographic profile of specific survivor audiences.
Full Text Available This paper deals with the semantic web and web ontology. The existing ontology development processes are not catered towards casual web ontology development, a notion analogous to standard web page development. Ontologies have become common on the World-Wide Web. Key features of this process include easy and rapid creation of ontological skeletons, searching and linking to existing ontologies and a natural language-based technique to improve presentation of ontologies. Ontologies, however, vary greatly in size, scope and semantics. They can range from generic upper-level ontologies to domain-specific schemas. The success of the Semantic Web is based on the existance of numerous distributed ontologies, using which users can annotate their data, thereby enabling shared machine readable content. This paper elaborates the stages in a casual ontology development process.
Godsk, Mikkel; Petersen, Anja Bechmann
This chapter presents a model (WebCom) for understanding and analyzing Web site-mediated communication, also referred to as Web site communication. The model combines three theoretical approaches - communication, medium, and activity theory - into one generic model that benefits from each...... of the approaches' strengths. Furthermore, it is discussed and shortly demonstrated how WebCom can be used for analytical and design purposes with YouTube as an example. The chapter concludes that WebCom is able to serve as a theoretically-based model for understanding complex Web site communication situations...... in their entirety, and that such thoroughly approach is required for successful computer mediated communication (CMC) when communicating across cultures and contexts....
Sandhyarani, Ramancha; Gyani, Jayadev; 10.5121/acij.2012.3205
This paper support the concept of a community Web directory, as a Web directory that is constructed according to the needs and interests of particular user communities. Furthermore, it presents the complete method for the construction of such directories by using web usage data. User community models take the form of thematic hierarchies and are constructed by employing clustering approach. We applied our methodology to the ODP directory and also to an artificial Web directory, which was generated by clustering Web pages that appear in the access log of an Internet Service Provider. For the discovery of the community models, we introduced a new criterion that combines a priori thematic informativeness of the Web directory categories with the level of interest observed in the usage data. In this context, we introduced and evaluated new clustering method. We have tested the methodology using access log files which are collected from the proxy servers of an Internet Service Provider and provided results that ind...
Full Text Available Susan Brandzel,1 Dori E Rosenberg,1 Dianne Johnson,1 Mary Bush,1 Karla Kerlikowske,2–5 Tracy Onega,6,7 Louise Henderson,8 Larissa Nekhlyudov,9,10 Wendy DeMartini,11 Karen J Wernli1 1Group Health Research Institute, Group Health Cooperative, Seattle, WA, 2Department of Medicine, 3Department of Epidemiology, 4Department of Biostatistics, 5Department of Veterans Affairs, University of California, San Francisco, San Francisco, CA, 6Department of Biomedical Data Science, 7Department of Epidemiology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, 8Department of Radiology, University of North Carolina, Chapel Hill, NC, 9Department of Population Medicine, Harvard Medical School, 10Department of Medicine, Brigham and Women’s Hospital, Boston, MA, 11Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA Background: After treatment for breast cancer, most women receive an annual surveillance mammography to look for subsequent breast cancers. Supplemental breast MRI is sometimes used in addition to mammography despite the lack of clinical evidence for it. Breast imaging after cancer treatment is an emotionally charged experience, an important part of survivorship care, and a topic about which limited patient information exists. We assessed women’s experiences and preferences about breast cancer surveillance imaging with the goal of determining where gaps in care and knowledge could be filled. Participants and methods: We conducted six focus groups with a convenience sample of 41 women in California, North Carolina, and New Hampshire (USA. Participants were aged 38–75 years, had experienced stage 0–III breast cancer within the previous 5 years, and had completed initial treatment. We used inductive thematic analysis to identify key themes from verbatim transcripts. Results: Women reported various types and frequencies of surveillance imaging and a range of surveillance imaging
Chahal, P.; Singh, M.; Kumar, S.
With the enormous amount of information presented on the web, the retrieval of relevant information has become a serious problem and is also the topic of research for last few years. The most common tools to retrieve information from web are search engines like Google. The Search engines are usually based on keyword searching and indexing of web pages. This approach is not very efficient as the result-set of web pages obtained include large irrelevant pages. Sometimes even the entire result-set may contain lot of irrelevant pages for the user. The next generation of search engines must address this problem. Recently, many semantic web search engines have been developed like Ontolook, Swoogle, which help in searching meaningful documents presented on semantic web. In this process the ranking of the retrieved web pages is very crucial. Some attempts have been made in ranking of semantic web pages but still the ranking of these semantic web documents is neither satisfactory and nor up to the user's expectations. In this paper we have proposed a semantic web based document ranking scheme that relies not only on the keywords but also on the conceptual instances present between the keywords. As a result only the relevant page will be on the top of the result-set of searched web pages. We explore all relevant relations between the keywords exploring the user's intention and then calculate the fraction of these relations on each web page to determine their relevance. We have found that this ranking technique gives better results than those by the prevailing methods.
Glez-Peña, Daniel; Lourenço, Anália; López-Fernández, Hugo; Reboiro-Jato, Miguel; Fdez-Riverola, Florentino
Web services are the de facto standard in biomedical data integration. However, there are data integration scenarios that cannot be fully covered by Web services. A number of Web databases and tools do not support Web services, and existing Web services do not cover for all possible user data demands. As a consequence, Web data scraping, one of the oldest techniques for extracting Web contents, is still in position to offer a valid and valuable service to a wide range of bioinformatics applic...
Raimond, Yves; Scott, Tom; Oliver, Silver; Sinclair, Patrick; Smethurst, Michael
The BBC publishes large amounts of content online, as text, audio and video. As the amount of content grows, we need to make it easy for users to locate items of interest and to draw coherent journeys across them. In this chapter, we describe our use of Semantic Web technologies for achieving this goal. We focus in particular on three BBC Web sites: BBC Programmes, BBC Music and BBC Wildlife Finder, and how those Web sites effectively use the wider Web as their Content Management System.
Sanz Asenjo, Alejandro
Este proyecto abordará la tecnología WebGL, que permite la presentación de gráficos 3D en páginas web, y la dificultad que existe actualmente en su estudio y enseñanza. Es una tecnología nueva, con pocos ejemplos en la web o en los libros y que tiene una alta curva de aprendizaje. Debido a esto, el objetivo de este proyecto es obtener un sistema web de aprendizaje basado en tutoriales, el cual será utilizado como herramienta docente en la asignatura “Programación de Aplicaciones Grá...
Jansen, Bernard J
This lecture presents an overview of the Web analytics process, with a focus on providing insight and actionable outcomes from collecting and analyzing Internet data. The lecture first provides an overview of Web analytics, providing in essence, a condensed version of the entire lecture. The lecture then outlines the theoretical and methodological foundations of Web analytics in order to make obvious the strengths and shortcomings of Web analytics as an approach. These foundational elements include the psychological basis in behaviorism and methodological underpinning of trace data as an empir
Writing for the Web unites theory, technology, and practice to explore writing and hypertext for website creation. It integrates such key topics as XHTML/CSS coding, writing (prose) for the Web, the rhetorical needs of the audience, theories of hypertext, usability and architecture, and the basics of web site design and technology. Presenting information in digestible parts, this text enables students to write and construct realistic and manageable Web sites with a strong theoretical understanding of how online texts communicate to audiences. Key features of the book
Song, Hayeon; Nam, Yujung; Gould, Jessica; Sanders, W Scott; McLaughlin, Margaret; Fulk, Janet; Meeske, Kathleen A; Ruccione, Kathleen S
This study investigates how cancer survivors construct their identities and the impact on their psychological health, as measured by depression and survivor self-efficacy. Fourteen young adult survivors of pediatric cancer participated in a customized social networking and video blog intervention program, the LIFECommunity, over a 6-month period. Survivors were asked to share their stories on various topics by posting video messages. Those video blog postings, along with survey data collected from participants, were analyzed to see how cancer survivors expressed their identities, and how these identities are associated with survivors' psychosocial outcomes. In survivors who held negative stereotypes about cancer survivors, there was a positive relationship with depression while positive stereotypes had a marginal association with cancer survivor efficacy. Findings indicate that although pediatric cancer survivors often do not publicly discuss a "cancer survivor identity," they do internalize both positive and negative stereotypes about cancer survivorship. It is important for practitioners to be aware of the long-term implications of cancer survivor identity and stereotypes.
Stubblefield, Michael D; Hubbard, Gill; Cheville, Andrea; Koch, Uwe; Schmitz, Kathryn H; Dalton, Susanne Oksbjerg
Cancer rehabilitation is a rapidly emerging and evolving medical field in both Europe and the United States, in large part because of increases in the number of cancer survivors. Although few argue with the need to restore function and quality of life to patients affected by cancer and its treatments, differences exist between European countries with regard to the funding, accessibility, and even the definition of cancer rehabilitation services. In the United States, there is tremendous variability in the provision of rehabilitation services resulting from a variety of factors, including a lack of highly trained cancer rehabilitation physicians and therapists as well as a lack of comprehensive cancer rehabilitation programs, even at the majority of top cancer centers. Although studies evaluating the effectiveness of rehabilitation programs in the cancer setting, particularly exercise, have influenced clinical decision-making in both Europe and the United States for some time, this emerging evidence base also is now starting to influence guideline and policy making. Coordinated research efforts are essential to establish a robust framework to support future investigation and establish shared initiatives. Determining the best way forward for cancer survivors will require investment in large-scale prospective cohort studies that sufficiently describe their rehabilitation needs through the continuum of the survivorship experience.
Hendler, James [Rensselaer Polytechnic Institute
As more and more data and information becomes available on the Web, new technologies that use explicit semantics for information organization are becoming desirable. New terms such as Linked Data, Semantic Web and Web 3.0 are used more and more, although there is increasing confusion as to what each means. In this talk, I will describe how different sorts of models can be used to link data in different ways. I will particularly explore different kinds of Web applications, from Enterprise Data Integration to Web 3.0 startups, government data release, the different needs of Web 2.0 and 3.0, the growing interest in “semantic search”, and the underlying technologies that power these new approaches.
Appearance of Bitcoin raise up evolution in currency. Blockchain database also raise up possibilities to share important data between untrusted peers. In this paper, we propose Arachneum, a decentralized, distributed, and model-view-controller-based web service using blockchain and new privileges model. Therefore, we can enjoy the freedom against censorship of government or organizations, keep transparency of our web services, fork our web services, and create/read/update/delete(CRUD) all mod...
I present an overview of the study of infrared singularities through the eikonal approximation and the concept of webs. Our work reveals the interesting structure of an infinite subclass of webs, Multiple Gluon Exchange Webs. We find that they can be expressed as sums of products of functions depending upon only a single cusp angle, spanned by a simple basis of functions, and conjecture that this structure will hold to all orders.
The Invisible Web is often discussed in the academic context, where its contents (mainly in the form of databases) are of great importance. But this discussion is mainly based on some seminal research done by Sherman and Price (2001) and Bergman (2001), respectively. We focus on the types of Invisible Web content relevant for academics and the improvements made by search engines to deal with these content types. In addition, we question the volume of the Invisible Web as stated by Bergman. Ou...
2.1 Demographics The initial page that the user encounters when accessing the VoI web application is Demographics (Fig. 1). On this page , the user...deck is empty, the web application sets up the next deck for the user or sends the user to the Results page if all decks have been played. The user...confirmation that the submittal was successful or not successful. This ends the users’ interaction with the web application. 5 Fig. 4 Results page
Young, Robert R
Genetic toxicology is the scientific discipline dealing with the effects of chemical, physical and biological agents on the heredity of living organisms. The Internet offers a wide range of online digital resources for the field of Genetic Toxicology. The history of genetic toxicology and electronic data collections are reviewed. Web-based resources at US National Library of Medicine (NLM), including MEDLINE, PUBMED, Gateway, Entrez, and TOXNET, are discussed. Search strategies and Medical Subject Headings (MeSH) are reviewed in the context of genetic toxicology. The TOXNET group of databases are discussed with emphasis on those databases with genetic toxicology content including GENE-TOX, TOXLINE, Hazardous Substances Data Bank, Integrated Risk Information System, and Chemical Carcinogenesis Research Information System. Location of chemical information including chemical structure and linkage to health and regulatory information using CHEMIDPLUS at NLM and other databases is reviewed. Various government agencies have active genetic toxicology research programs or use genetic toxicology data to assist fulfilling the agency's mission. Online resources at the US Food and Drug Administration (FDA), the US Environmental Protection Agency (EPA), the National Institutes of Environmental Health Sciences, and the National Toxicology Program (NTP) are outlined. Much of the genetic toxicology for pharmaceuticals, industrial chemicals and pesticides that is performed in the world is regulatory-driven. Regulatory web resources are presented for the laws mandating testing, guidelines on study design, Good Laboratory Practice (GLP) regulations, and requirements for electronic data collection and reporting. The Internet provides a range of other supporting resources to the field of genetic toxicology. The web links for key professional societies and journals in genetic toxicology are listed. Distance education, educational media resources, and job placement services are also
the information out of various types of EXIF digital camera files and show it in a reasonably consistent way (schema), 2003. http://www.w3.org/2000...many documents are not expressible in logica at all, and many in logic but not in N3. However, we are building a system for which a prime goal is the...demonstrate that conventional logica programming tools are efficent and straightforwradly adapted to semantic web work. • Jena RDF toolkit now accepts N3 as
Gardner, Lyza; Grigsby, Jason
Having taught and carried out research in LSP and business communication for many years, I have come across, again and again, the problems arising from the inferior status of language in the business environment. Being convinced that it does not have to be so, instead of going on trying to convin...... non-linguistically trained colleagues of the importance of language via the usual arguments, I suggest that we let them experience the problems arising from the non-recognition of the importance of language via a Web communication crash course, inspired by a course taught to BA students...
Full Text Available The rapid growth of the web and the lack of structure or an integrated schema create various issues to access the information for users. All users’ access on web information are saved in the related server log files. The circumstance of using these files is implemented as a resource for finding some patterns of user's behavior. Web mining is a subset of data mining and it means the mining of the related data from WWW, which is categorized into three parts including web content mining, web structure mining and web usage mining, based on the part of data, which is mined. It seems necessary to have a technique, which is capable of learning the users’ interests and based on the interests, which could filter the unrelated interests automatically or it could offer the related information to the user in reasonable amount of time. The web usage mining makes a profile from users to recognize them and it has direct relationship to web personalizing. The primary objective of personalizing systems is to prepare the thing, which is required by users, without asking them explicitly. In the other way, formal models prepare the possibility of system’s behavior modeling. The Petri and queue nets as some samples of these models can analyze the user's behavior in web. The primary objective of this paper is to present a colored Petri net to model the user's interactions for offering a list of pages recommendation to them in web. Estimating the user's behavior is implemented in some cases like offering the proper pages to continue the browse in web, ecommerce and targeted advertising. The preliminary results indicate that the proposed method is able to improve the accuracy criterion 8.3% rather static method.
Jensen, Christian S.
community is hard at work inventing means of efficiently supporting new spatial query functionality. Points of interest with a web presence, called spatial web objects, have a location as well as a textual description. Spatio-textual queries return such objects that are near a location argument...... and are relevant to a text argument. An important element in enabling such queries is to be able to rank spatial web objects. Another is to be able to determine the relevance of an object to a query. Yet another is to enable the efficient processing of such queries. The talk covers recent results on spatial web...
Full Text Available There are several studies dealing with the differences between sites originated by men and women. However, these references are mainly related to the "output", the final web site. In our research we examined the input side of web designing. We thoroughly analysed a number of randomly selected web designer softwares to see, whether and to what extent the templates they offer determine the final look of an individual's website. We have found that most of them are typical masculine templates, which makes it difficult to any women to design a feminine looking website. It can be one of the reasons of the masculine website hegemony on the web.
Politiken 01.01.2014 14:16 Danskerne skød nytåret ind med et brag, men for enkeltes vedkommende gik det galt, da nytårskrudtet blev tændt. Skadestuerne har behandlet 73 personer for fyrværkeriskader mellem klokken 18 i aftes og klokken 06 i morges. Det viser en optælling, som Politiken har...... foretaget på baggrund af tal fra Ulykkes Analyse Gruppen på Odense Universitetshospital. Artiklen er også bragt i: Alt om Ikast Brande (web), Lemvig Folkeblad (web), Politiken (web), Dagbladet Ringkjøbing Skjern (web)....
Thorlund Jepsen, Erik; Seiden, Piet; Ingwersen, Peter Emil Rerup
Because of the increasing presence of scientific publications on the Web, combined with the existing difficulties in easily verifying and retrieving these publications, research on techniques and methods for retrieval of scientific Web publications is called for. In this article, we report on the......Vista and AllTheWeb retrieved a higher degree of accessible scientific content than Google. Because of the search engine cutoffs of accessible URLs, the feasibility of using search engine output for Web content analysis is also discussed....
Lindsay, Julian; Kabir, Masrura; Gilroy, Nicole; Dyer, Gemma; Brice, Lisa; Moore, John; Greenwood, Matthew; Hertzberg, Mark; Gottlieb, David; Larsen, Stephen R; Hogg, Megan; Brown, Louisa; Huang, Gillian; Tan, Jeff; Ward, Christopher; Kerridge, Ian
In addition to prescribed conventional medicines, many allogeneic hematopoietic stem cell transplant (HSCT) survivors also use complementary and alternative medical therapies (CAM), however, the frequency and types of CAMs used by allogeneic HSCT survivors remain unclear. Study participants were adults who had undergone an allogeneic HSCT between 1st January 2000 and 31st December 2012. Participants completed a 402-item questionnaire regarding the use of CAM, medical complications, specialist referrals, medications and therapies, infections, vaccinations, cancer screening, lifestyle, and occupational issues and relationship status following stem cell transplantation. A total of 1475 allogeneic HSCT were performed in the study period. Of the 669 recipients known to be alive at study sampling, 583 were contactable and were sent study packs. Of 432 participants who returned the completed survey (66% of total eligible, 76% of those contacted), 239 (54.1%) HSCT survivors used at least one form of CAM. These included dietary modification (13.6%), vitamin therapy (30%), spiritual or mind-body therapy (17.2%), herbal supplements (13.5%), manipulative and body-based therapies (26%), Chinese medicine (3.5%), reiki (3%), and homeopathy (3%). These results definitively demonstrate that a large proportion of HSCT survivors are using one or more form of CAM therapy. Given the potential benefits demonstrated by small studies of specific CAM therapies in this patient group, as well as clearly documented therapies with no benefit or even toxicity, this result shows there is a large unmet need for additional studies to ascertain efficacy and safety of CAM therapies in this growing population.
Meroño-Peñuela, A.; Ashkpour, A.
The Semantic Web is an extension of the Web through standards by the World Wide Web Consortium (W3C) . These standards promote common data formats and exchange protocols on the Web, most fundamentally the Resource Description Framework (RDF). Its ultimate goal is to make the Web a suitable data s
Veronica F. McGowan
Full Text Available The development of policy to handle the increasingly diverse issues that arise from web content management is becoming a concern for academic institutions. An exploratory investigation that seeks institutional web content manager perspectives from higher educational settings on current web publishing and hosting policy and issues is presented as a mixed-method research design, using both quantitative and qualitative methodologies, to investigate how field factors influence policy creation. A web-based version of a survey instrument was designed, piloted, and implemented for this investigation, and data is presented, and discussed in relation to current field literature. Findings indicate that web hosting and publishing policies increasingly fall under the purview of institutional Communications or Public Relations departments and that policy elements concerning web content do not yet match field recommendations in several key areas.
Web map is the hybrid of map and the World Wide Web (known as Web). It is usually created with WebGIS techniques. With the rapid social development, web maps oriented the public are facing pressure that dissatisfy the increased demanding. The geocoding database plays a key role in supporting query services effectively. The traditional geocoding method is laborious and time-consuming. And there is much online spatial information, which would be the supplementary information source for geocoding. Therefore, this paper discusses how to improve query services by web mining. The improvement can be described from three facets: first, improving location query by discovering and extracting address information from the Web to extend geocoding database. Second, enhancing the ability of optimum path query of public traffic and buffer query by spatial analyzing and reasoning on the extended geocoding database. Third, adjusting strategies of collecting data according to patterns discovered by web map query mining. Finally, this paper presents the designing of the application system and experimental results.
Koch, Bert F.; Eichler, Gerald; Fischer, Mike; Fünfstück, Falk; Hußmann, Heinrich; Konermann, Ansgar W.; Thomas, Anne
Aus der Einleitung: "Dieser Artikel beschreibt Ziele und Lösungsansätze des Projekts ProjectWeb, einer web-basierten Arbeitsumgebung für räumlich verteilte Projekte, das im Rahmen des diesjährigen Komplexpraktikums durch Studenten am Institut für Software- und Multimediatechnik der Fakultät Informatik (TU Dresden) bearbeitet wird ."
Mandal, Chittaranjan; Sinha, Vijay Luxmi; Reade, Christopher M. P.
The architecture of a web-based course management tool that has been developed at IIT [Indian Institute of Technology], Kharagpur and which manages the submission of assignments is discussed. Both the distributed architecture used for data storage and the client-server architecture supporting the web interface are described. Further developments…
Oyama, H; Wakao, F; Mishina, T; Lu, Y; Honjo, A
We previously developed a system with which we have created more than 100 virtual cancer images from CT or MR data of individual patients with cancer (Cancer Edutainment Virtual Reality Theater: CEVRT). These images can be used to help explain procedures, findings, etc. to the patient, to obtain informed consent, to simulate surgery, and to estimate cancer invasion to surrounding organs. We recently developed a web-based object-oriented database both to access these cancer images and to register medical images at international research sites via the Internet. In this report, we introduce an international medical VR data warehouse created using an object-oriented database.
Bock, K W; D. VAN DEN POEL; Manigart, S.
Several recent studies have explored the virtues of behavioral targeting and personalization for online advertising. In this paper, we add to this literature by proposing a cost-effective methodology for the prediction of demographic web site visitor profiles that can be used for web advertising targeting purposes. The methodology involves the transformation of web site visitors’ clickstream patterns to a set of features and the training of Random Forest classifiers that generate predictions ...
DiMatteo, M Robin
The goal of this paper is to examine emerging issues in consumer-provider communication and patient adherence to cancer prevention, screening, diagnosis, treatment, and coping with survivorship. Many factors that have been shown to affect adherence can be supported or hindered by provider-patient communication, including the provider-patient relationship, patients' beliefs, social and cultural norms, family and social support, mood, and behavioral management. Six research questions are posed, and substantive and methodological recommendations are offered for empirical research on the measurement and achievement of patient adherence.
Deisboeck, Thomas S; Wang, Zhihui; Macklin, Paul; Cristini, Vittorio
Simulating cancer behavior across multiple biological scales in space and time, i.e., multiscale cancer modeling, is increasingly being recognized as a powerful tool to refine hypotheses, focus experiments, and enable more accurate predictions. A growing number of examples illustrate the value of this approach in providing quantitative insights in the initiation, progression, and treatment of cancer. In this review, we introduce the most recent and important multiscale cancer modeling works that have successfully established a mechanistic link between different biological scales. Biophysical, biochemical, and biomechanical factors are considered in these models. We also discuss innovative, cutting-edge modeling methods that are moving predictive multiscale cancer modeling toward clinical application. Furthermore, because the development of multiscale cancer models requires a new level of collaboration among scientists from a variety of fields such as biology, medicine, physics, mathematics, engineering, and computer science, an innovative Web-based infrastructure is needed to support this growing community.
Perhaps the most significant tool of our internet age is the web search engine, providing a powerful interface for accessing the vast amount of information available on the world wide web and beyond. While still in its infancy compared to the knowledge tools that precede it - such as the dictionary or encyclopedia - the impact of web search engines on society and culture has already received considerable attention from a variety of academic disciplines and perspectives. This article aims to organize a meta-discipline of “web search studies,” centered around a nucleus of major research on web search engines from five key perspectives: technical foundations and evaluations; transaction log analyses; user studies; political, ethical, and cultural critiques; and legal and policy analyses.
Lovich, J.E.; Ennen, J.R.; Madrak, S.; Meyer, K.; Loughran, C.; Bjurlin, C.; Arundel, T.; Turner, W.; Jones, C.; Groenendaal, G.M.
We studied a Desert Tortoise (Gopherus agassizii) population at a large wind energy generation facility near Palm Springs, California over six field seasons from 1997 to 2010. We compared growth and demographic parameters to populations living in less disturbed areas; as well as populations of the closely-related and newly-described G. morafkai elsewhere in the Sonoran Desert of Arizona. We marked 69 individuals of all size classes and estimated a population size of 96 tortoises, or about 15.4/km2. Growth rates for males were lower than reported elsewhere, although maximum body size was larger. The smallest female with shelled eggs was 221 mm and males mature at over 200 mm. Mean male size was greater than that of females. The adult sex ratio was not significantly different from unity. Size frequency histograms were similar over time and when compared to most, but not all, G. morafkai populations in the Sonoran Desert. For a cohort of adult females, we estimated mortality at 8.4% annually due, in part, to site operations. This value was low in comparison to many other populations during the same time period. Other than possible differences in growth rate of males and the high survivorship of females, there appear to be few differences between this population and those in more natural areas. The high productivity of food plants at the site and its limited public access may contribute to the overall stability of the population. However, the effects of utility-scale renewable energy development on tortoises in other, less productive, areas are unknown. Additional research (especially controlled and replicated before and after studies) is urgently needed to address this deficiency because of forecasted expansion of utility-scale renewable energy development in the future.
Vissers, Pauline A J; Mols, Floortje; Thong, Melissa S Y;
to clinical data from the population-based Eindhoven Cancer Registry. Diabetes status was self-reported and neuropathic symptoms were measured with the European Organization for Research and Treatment of Cancer quality of life questionnaire-chemotherapy-induced peripheral neuropathy 20 (EORTC QLQ-CIPN20......PURPOSE: This study assessed differences in neuropathic symptoms between colorectal cancer (CRC) patients with and without diabetes. Moreover, we aimed to explore whether neuropathic symptoms could be explained by the receipt of chemotherapy as it was previously shown that cancer patients...... with diabetes less often receive chemotherapy. METHODS: Data from a cross-sectional study among CRC patients (2-11 years after diagnosis) was used. Data were collected by the Patient Reported Outcomes Following Initial treatment and Long term Evaluation of Survivorship (PROFILES) registry which is linked...
Temeika L. Fairley, PhD
Full Text Available IntroductionNearly 12 million cancer survivors are living in the United States. Few state-based studies have examined the health status and health-related quality of life (HRQOL of this growing population. The objective of this study was to use Massachusetts Behavioral Risk Factor Surveillance System (BRFSS data to describe cancer survivors’ demographics, health behaviors, quality of life, use of preventive care services, and influenza vaccination rates.MethodsThe demographic characteristics of cancer survivors and respondents without cancer were estimated on the basis of responses to questions in the 2006 Massachusetts BRFSS. We used multivariate logistic regression to compare health behaviors, comorbidities, quality of life, and cancer screening and influenza vaccination rates for cancer survivors compared with respondents who did not have cancer.ResultsCancer survivors and respondents who did not have cancer had similar rates of health behavioral risk factors including smoking, obesity, and physical activity. Rates of chronic disease (eg, heart disease, asthma and disability were higher among cancer survivors. Cancer survivors reported higher rates of influenza vaccination and breast, colorectal, and cervical cancer screening than did respondents who did not have cancer. Survivors’ self-reported health status and HRQOL (physical and mental health improved as length of survivorship increased.ConclusionThis state-based survey allowed Massachusetts to assess health-related issues for resident cancer survivors. These findings will help state-based public health planners develop interventions to address the long-term physical and psychosocial consequences of cancer diagnosis and treatment.
WebQuest is a popular inquiry-oriented activity in which learners use Web resources. Since the creation of the innovation, almost 15 years ago, the Web has changed significantly, while the WebQuest technique has changed little. This article examines possible applications of new Web trends on WebQuest instructional strategy. Some possible…