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  1. CSR1 Suppresses Tumor Growth and Metastasis of Prostate Cancer

    OpenAIRE

    Yu, Guoying; Tseng, George C.; Yu, Yan Ping; Gavel, Tim; Nelson, Joel; Wells, Alan; Michalopoulos, George; Kokkinakis, Demetrius; Luo, Jian-Hua

    2006-01-01

    Prostate cancer is frequent among men over 45 years of age, but it generally only becomes lethal with metastasis. In this study, we identified a gene called cellular stress response 1 (CSR1) that was frequently down-regulated and methylated in prostate cancer samples. Survival analysis indicated that methylation of the CSR1 promoter, and to a lesser extent down-regulation of CSR1 protein expression, was associated with a high rate of prostate cancer metastasis. Forced expression of CSR1 in pr...

  2. CSR1 suppresses tumor growth and metastasis of prostate cancer.

    Science.gov (United States)

    Yu, Guoying; Tseng, George C; Yu, Yan Ping; Gavel, Tim; Nelson, Joel; Wells, Alan; Michalopoulos, George; Kokkinakis, Demetrius; Luo, Jian-Hua

    2006-02-01

    Prostate cancer is frequent among men over 45 years of age, but it generally only becomes lethal with metastasis. In this study, we identified a gene called cellular stress response 1 (CSR1) that was frequently down-regulated and methylated in prostate cancer samples. Survival analysis indicated that methylation of the CSR1 promoter, and to a lesser extent down-regulation of CSR1 protein expression, was associated with a high rate of prostate cancer metastasis. Forced expression of CSR1 in prostate cancer cell lines DU145 and PC3 resulted in a two- to threefold decrease in colony formation and a 10-fold reduction in anchorage-independent growth. PC3 cells stably expressing CSR1 had an average threefold decrease in their ability to invade in vitro. Expression of CSR1 in PC3 cell xenografts produced a dramatic reduction (>8-fold) in tumor size, rate of invasion (0 versus 31%), and mortality (13 versus 100%). The present findings suggest that CSR1 is a potent tumor sup-pressor gene. PMID:16436673

  3. Oncogenic Activity of miR-650 in Prostate Cancer Is Mediated by Suppression of CSR1 Expression

    OpenAIRE

    Zuo, Ze-Hua; Yu, Yan P.; Ding, Ying; Liu, Silvia; Martin, Amantha; Tseng, George; Luo, Jian-Hua

    2015-01-01

    Cellular stress response 1 (CSR1) is a tumor suppressor gene whose expression was frequently down-regulated in prostate cancer. The mechanism of its down-regulation, however, is not clear. Here, we show that the 3′ untranslated region of CSR1 contains a target site of miR-650. High level of miR-650 was found in prostate cancer samples and cell lines. Degradation of miR-650 by specific inhibitor dramatically increased the expression levels of CSR1. Interaction between miR-650 and its target si...

  4. Oncogenic Activity of miR-650 in Prostate Cancer Is Mediated by Suppression of CSR1 Expression.

    Science.gov (United States)

    Zuo, Ze-Hua; Yu, Yan P; Ding, Ying; Liu, Silvia; Martin, Amantha; Tseng, George; Luo, Jian-Hua

    2015-07-01

    Cellular stress response 1 (CSR1) is a tumor suppressor gene whose expression was frequently down-regulated in prostate cancer. The mechanism of its down-regulation, however, is not clear. Here, we show that the 3' untranslated region of CSR1 contains a target site of miR-650. High level of miR-650 was found in prostate cancer samples and cell lines. Degradation of miR-650 by specific inhibitor dramatically increased the expression levels of CSR1. Interaction between miR-650 and its target site in the 3' untranslated region was validated through luciferase reporter system. Mutation at the target site completely abrogated the activity of miR-650 on the 3' untranslated region of CSR1. Inhibition of miR-650 reversed the expression suppression of CSR1, suppressed colony formation, and blocked cell cycle entry to the S phase of both PC3 and DU145 cells. Animal model showed significant decrease of tumor volume, rate of metastasis, and mortality of severe combined immunodeficient mice xenografted with PC3 or DU145 cells transformed with inhibitor of miR-650. Our analyses demonstrate that suppression of CSR1 expression is a novel mechanism critical for the oncogenic activity of miR-650. PMID:25956032

  5. How Human Resource Professionals Use Electronic Channels to Communicate CSR : A case study focused on Solvay's French industrial sites

    OpenAIRE

    Fournet, Clara; Pauly, Marissa

    2015-01-01

    Corporate Social Responsibility (CSR) has become a large concern for many companies with the rise of globalization. Oftentimes, companies are encouraged to communicate CSR externally, but not internally. This research focuses upon the internal communication of CSR, specifically how Human Resource (HR) professionals use electronic channels to communicate to employees. The scope of this research is focused solely upon HR professionals within Solvay’s French industrial sites, which produce chemi...

  6. CSR STRATEGIES

    OpenAIRE

    LAURENTIU BARANGA; ION STEGAROIU

    2011-01-01

    Corporate Social Responsibility (CSR) has got three components: economic responsibility of shareholders, corporate environmental responsibility, corporate responsibility of the society. Each component of the CSR has its own features, according to which adequate individual behaviour is established. Knowing these features is very important in CSR strategy development.

  7. CSR communication

    DEFF Research Database (Denmark)

    Golob, Ursa; Podnar, Klement; Elving, Wim;

    2013-01-01

    a summary of the state of CSR communication knowledge. Design/methodology/approach – The existing literature on CSR communication was approached via systematic review. with a combination of conventional and summative qualitative content analysis. The final dataset contained 90 papers from two main business...... communications. The most important outlets for CSR communication-related topics are Journal of Business Ethics and Corporate Communications: An International Journal. Originality/value – This paper represents the first attempt to perform a systematic and comprehensive overview of CSR communication papers......Purpose – This paper aims to introduce the special issue on CSR communication attached to the First International CSR Communication Conference held in Amsterdam in October 2011. The aim of the introduction is also to review CSR communication papers published in scholarly journals in order to make...

  8. Political CSR

    DEFF Research Database (Denmark)

    Jeppesen, Søren; Morsing, Mette

    We engage a discussion of political CSR in SMEs in an African context. Based on critical observations on Western MNC CSR action in emerging economies that holds counterproductive implications for social development, political economists have argued that business profit far more than society in de...... development in local African communities. Our findings extend political CSR research by directing attention to how the corporate influence in developing economies does not only emerge from MNCs but is also established and retained by SMEs CSR work.......We engage a discussion of political CSR in SMEs in an African context. Based on critical observations on Western MNC CSR action in emerging economies that holds counterproductive implications for social development, political economists have argued that business profit far more than society...... in developing economies from CSR. In this paper we argue that local SMEs CSR work have strong influence in developing economies, that also includes counterproductive influence for social development. Based on empirical findings from African countries, we conceptualize how CSR in African SMEs differ from...

  9. Identification of a Csr system in Serratia marcescens 2170.

    Science.gov (United States)

    Ito, Manabu; Nomura, Kazuki; Sugimoto, Hayuki; Watanabe, Takeshi; Suzuki, Kazushi

    2014-01-01

    The carbon storage regulator (Csr) global regulatory system is conserved in many eubacteria and coordinates the expression of various genes that facilitate adaptation during the major physiological growth phase. The Csr system in Escherichia coli comprises an RNA-binding protein, CsrA; small non-coding RNAs, CsrB and CsrC; and a decay factor for small RNAs, CsrD. In this study, we identified the Csr system in Serratia marcescens 2170. S. marcescens CsrA was 97% identical to E. coli CsrA. CsrB and CsrC RNAs had typical stem-loop structures, including a GGA motif that is the CsrA binding site. CsrD was composed of N-terminal two times transmembrane region and HAMP-like, GGDEF, and EAL domains. Overexpression of S. marcescens csr genes complemented the phenotype of E. coli csr mutants. S. marcescens CsrD affected the decay of CsrB and CsrC RNAs in E. coli. These results suggest that the Csr system in S. marcescens is composed of an RNA-binding protein, two Csr small RNAs, and a decay factor for Csr small RNAs.

  10. Identification of a Csr system in Serratia marcescens 2170.

    Science.gov (United States)

    Ito, Manabu; Nomura, Kazuki; Sugimoto, Hayuki; Watanabe, Takeshi; Suzuki, Kazushi

    2014-01-01

    The carbon storage regulator (Csr) global regulatory system is conserved in many eubacteria and coordinates the expression of various genes that facilitate adaptation during the major physiological growth phase. The Csr system in Escherichia coli comprises an RNA-binding protein, CsrA; small non-coding RNAs, CsrB and CsrC; and a decay factor for small RNAs, CsrD. In this study, we identified the Csr system in Serratia marcescens 2170. S. marcescens CsrA was 97% identical to E. coli CsrA. CsrB and CsrC RNAs had typical stem-loop structures, including a GGA motif that is the CsrA binding site. CsrD was composed of N-terminal two times transmembrane region and HAMP-like, GGDEF, and EAL domains. Overexpression of S. marcescens csr genes complemented the phenotype of E. coli csr mutants. S. marcescens CsrD affected the decay of CsrB and CsrC RNAs in E. coli. These results suggest that the Csr system in S. marcescens is composed of an RNA-binding protein, two Csr small RNAs, and a decay factor for Csr small RNAs. PMID:24859866

  11. Antagonistic control of the turnover pathway for the global regulatory sRNA CsrB by the CsrA and CsrD proteins.

    Science.gov (United States)

    Vakulskas, Christopher A; Leng, Yuanyuan; Abe, Hazuki; Amaki, Takumi; Okayama, Akihiro; Babitzke, Paul; Suzuki, Kazushi; Romeo, Tony

    2016-09-19

    The widely conserved protein CsrA (carbon storage regulator A) globally regulates bacterial gene expression at the post-transcriptional level. In many species, CsrA activity is governed by untranslated sRNAs, CsrB and CsrC in Escherichia coli, which bind to multiple CsrA dimers, sequestering them from lower affinity mRNA targets. Both the synthesis and turnover of CsrB/C are regulated. Their turnover requires the housekeeping endonuclease RNase E and is activated by the presence of a preferred carbon source via the binding of EIIA(Glc) of the glucose transport system to the GGDEF-EAL domain protein CsrD. We demonstrate that the CsrB 3' segment contains the features necessary for CsrD-mediated decay. RNase E cleavage in an unstructured segment located immediately upstream from the intrinsic terminator is necessary for subsequent degradation to occur. CsrA stabilizes CsrB against RNase E cleavage by binding to two canonical sites adjacent to the necessary cleavage site, while CsrD acts by overcoming CsrA-mediated protection. Our genetic, biochemical and structural studies establish a molecular framework for sRNA turnover by the CsrD-RNase E pathway. We propose that CsrD evolution was driven by the selective advantage of decoupling Csr sRNA decay from CsrA binding, connecting it instead to the availability of a preferred carbon source. PMID:27235416

  12. State Cancer Profiles Web site

    Data.gov (United States)

    U.S. Department of Health & Human Services — The State Cancer Profiles (SCP) web site provides statistics to help guide and prioritize cancer control activities at the state and local levels. SCP is a...

  13. CsrA Inhibits Translation Initiation of Escherichia coli hfq by Binding to a Single Site Overlapping the Shine-Dalgarno Sequence

    OpenAIRE

    Baker, Carol; Eory, Lel; Yakhnin, Helen; Mercante, Jeffrey; Romeo, Tony; Babitzke, Paul

    2007-01-01

    Csr (carbon storage regulation) of Escherichia coli is a global regulatory system that consists of CsrA, a homodimeric RNA binding protein, two noncoding small RNAs (sRNAs; CsrB and CsrC) that function as CsrA antagonists by sequestering this protein, and CsrD, a specificity factor that targets CsrB and CsrC for degradation by RNase E. CsrA inhibits translation initiation of glgC, cstA, and pgaA by binding to their leader transcripts and preventing ribosome binding. Translation inhibition is ...

  14. CsrA Inhibits Translation Initiation of Escherichia coli hfq by Binding to a Single Site Overlapping the Shine-Dalgarno Sequence▿

    OpenAIRE

    Baker, Carol; Eory, Lel; Yakhnin, Helen; Mercante, Jeffrey; Romeo, Tony; Babitzke, Paul

    2007-01-01

    Csr (carbon storage regulation) of Escherichia coli is a global regulatory system that consists of CsrA, a homodimeric RNA binding protein, two noncoding small RNAs (sRNAs; CsrB and CsrC) that function as CsrA antagonists by sequestering this protein, and CsrD, a specificity factor that targets CsrB and CsrC for degradation by RNase E. CsrA inhibits translation initiation of glgC, cstA, and pgaA by binding to their leader transcripts and preventing ribosome binding. Translation inhibition is ...

  15. Empirical Analysis on CSR Communication in Romania: Transparency and Participation

    Directory of Open Access Journals (Sweden)

    Irina-Eugenia Iamandi

    2012-12-01

    Full Text Available In the specific field of corporate social responsibility (CSR, the participation of companies in supporting social and environmental issues is mainly analysed and/or measured based on their CSR communication policy; in this way, the transparency of the CSR reporting procedures is one of the most precise challenges for researchers and practitioners in the field. The main research objective of the present paper is to distinguish between different types of CSR participation by identifying the reasons behind CSR communication for a series of companies acting on the Romanian market. The descriptive analysis – conducted both at integrated and corporate level for the Romanian companies – took into account five main CSR communication related issues: CSR site, CSR report, CSR listing, CSR budget and CSR survey. The results highlight both the declarative/prescriptive and practical/descriptive perspectives of CSR communication in Romania, showing that the Romanian CSR market is reaching its full maturity. In more specific terms, the majority of the investigated companies are already using different types of CSR participation, marking the transition from CSR just for commercial purposes to CSR for long-term strategic use. The achieved results are broadly analysed in the paper and specific conclusions are emphasized.

  16. Progress of HIRFL-CSR Vacuum System

    Institute of Scientific and Technical Information of China (English)

    YangXiaotian; ZhangJunhui; MengJun; ZhangXijun; ZhangXiping; HouShengjun; HuZhenjun; NiuZhiwei; HaoBingan; WuHuimin

    2003-01-01

    The HIRFL-CSR vacuum system progressed steadily during the past year. The 2/3rd of CSR, injection beam line (SSC-CSR, m)'s vacuum chambers were installed in site in Jan. 2003 (Fig.l). The beam diagnostic devices were inserted in the chambers as well. The pressures in unbaked section were kept in 1~5×10-7 Pa range and in baked section were 2~5×10-9 Pa.

  17. CSR i detailmarkedet

    OpenAIRE

    Nielsen, Tobias; Jensen, Kristina; Friis, Christina

    2015-01-01

    This report examines CSR from the problem “which benefits does Rema 1000 get through their CSR initiatives and can CSR be viewed as a market strategy.” To help answer this problem, three questions have been made which helps with the analysis: 1) Why do Rema 1000 make CSR? 2) Which stakeholders benefits from Rema 1000 CSR initiatives? 3) Why is CSR viewed as an integrated norm on the retail market? This report also formulates a hypothesis “CSR have nothing or very little to do with Soc...

  18. csrR, a Paralog and Direct Target of CsrA, Promotes Legionella pneumophila Resilience in Water

    Science.gov (United States)

    Abbott, Zachary D.; Yakhnin, Helen; Babitzke, Paul

    2015-01-01

    ABSTRACT Critical to microbial versatility is the capacity to express the cohort of genes that increase fitness in different environments. Legionella pneumophila occupies extensive ecological space that includes diverse protists, pond water, engineered water systems, and mammalian lung macrophages. One mechanism that equips this opportunistic pathogen to adapt to fluctuating conditions is a switch between replicative and transmissive cell types that is controlled by the broadly conserved regulatory protein CsrA. A striking feature of the legionellae surveyed is that each of 14 strains encodes 4 to 7 csrA-like genes, candidate regulators of distinct fitness traits. Here we focus on the one csrA paralog (lpg1593) that, like the canonical csrA, is conserved in all 14 strains surveyed. Phenotypic analysis revealed that long-term survival in tap water is promoted by the lpg1593 locus, which we name csrR (for “CsrA-similar protein for resilience”). As predicted by its GGA motif, csrR mRNA was bound directly by the canonical CsrA protein, as judged by electromobility shift and RNA-footprinting assays. Furthermore, CsrA repressed translation of csrR mRNA in vivo, as determined by analysis of csrR-gfp reporters, csrR mRNA stability in the presence and absence of csrA expression, and mutation of the CsrA binding site identified on the csrR mRNA. Thus, CsrA not only governs the transition from replication to transmission but also represses translation of its paralog csrR when nutrients are available. We propose that, during prolonged starvation, relief of CsrA repression permits CsrR protein to coordinate L. pneumophila’s switch to a cell type that is resilient in water supplies. PMID:26060275

  19. CSR and Beyond

    DEFF Research Database (Denmark)

    Morsing, Mette; Strand, Robert

    2014-01-01

    Review of: CSR and Beyond. A Nordic Perspective Edited by Atle Midttun (Oslo: Cappelen Damm Akademisk, 2013)......Review of: CSR and Beyond. A Nordic Perspective Edited by Atle Midttun (Oslo: Cappelen Damm Akademisk, 2013)...

  20. CSR as Governmentality

    OpenAIRE

    Vallentin, Steen; Murillo, David

    2009-01-01

    Modern governmental approaches to CSR (corporate social responsibility) have two distinguishing traits: they tend to define competitiveness as their primary concern and to make use of liberal and indirect means of steering. Contributing to a political understanding of CSR and focusing empirically on developments within the EU, this paper approaches CSR governance in general and competitiveness-driven CSR governance in particular from the point of view of an analytics of governmentality – thus...

  1. CSR og social udvikling

    OpenAIRE

    Marcussen, Helle Hye Secher; Sørensen, Johanne Wulff; Vodstrup, Ellis Hannah

    2010-01-01

    This project deals with the correlation between CSR and social development. Through an analysis of six Danish transnational companies’ CSR strategies, we examine to what extent CSR can contribute to a potential social development in development countries. Initially we define the concepts CSR and development according to our research question. This means that we theoretically specify development to the social aspects of development which are as follows; income, security at work, health, ...

  2. Business Ethics in CSR

    OpenAIRE

    Birkvad Bernth, Camilla; Houmøller Mortensen, Kasper; Calles, Mark Benjamin; Wind, Martin; Saalfeldt, Rie

    2013-01-01

    This project seeks to dissect the advent of CSR in business practice from the view of ethics. We perform this by laying out the theories of CSR, business ethics, deontology and utilitarianism. We then use the case studies of Lundbeck, The Body Shop, and British American Tobacco, to dissect some productions of CSR. These are compared to the above mentioned theories on ethics. We conclude that business ethics and CSR are only as good as the ethical base upon which they are built.

  3. CSR in SMEs

    DEFF Research Database (Denmark)

    Lund-Thomsen, Peter; Jamali, Dima; Vives, Antonio

    (Fox, 2005). In fact, when it comes to their role in promoting corporate social responsibility (CSR) in developing countries, the verdict is still out there in terms of the extent to which SMEs engage in CSR, and whether their CSR involvement makes any difference to the profitability of firms, workers......, and the environment in the South....

  4. Strategic CSR in Afghanistan

    DEFF Research Database (Denmark)

    Azizi, Sameer

    CSR is a rising phenomena in Afghanistan – but why are firms concerned about CSR in a least-developed context such as Afghanistan, and what are the strategic benefits? This paper is one of the first to explore these CSR issues in a least-developed country. It does so by focusing on CSR in the Afg......CSR is a rising phenomena in Afghanistan – but why are firms concerned about CSR in a least-developed context such as Afghanistan, and what are the strategic benefits? This paper is one of the first to explore these CSR issues in a least-developed country. It does so by focusing on CSR...... advantages through CSR in Afghanistan, and if so which and how these strategic benefits are gained. The paper shows that the developmental challenges of Afghanistan are the key explanations for why companies engage in CSR. Roshan has engaged in proactive CSR to overcome the contextual barriers for growth......’, but is based on a ‘license to operate’ motivation, where businesses have free room for maneuvering CSR towards their strategic priorities and business goals. Whether this creates a ‘shared value’ for both business and in particularly for the society is however still questionable....

  5. CSR communication: quo vadis?

    NARCIS (Netherlands)

    U. Golob; K. Podnar; W.J. Elving; A. Ellerup Nielsen; C. Thomsen; F. Schultz

    2013-01-01

    Purpose - This paper aims to introduce the special issue on CSR communication attached to the First International CSR Communication Conference held in Amsterdam in October 2011. The aim of the introduction is also to review CSR communication papers published in scholarly journals in order to make a

  6. CSR in SMEs

    DEFF Research Database (Denmark)

    Lund-Thomsen, Peter; Jamali, Dima; Vives, Antonio

    2014-01-01

    Purpose -The aim of this article is to analyse the potential and limitations of donor-financed management tools that seek to promote CSR in small and medium-sized enterprises in developing countries. Drawing on key insights from three streams of literature relating to institutional theory, critical...... perspectives on CSR in developing countries, and the literature on CSR and SMEs in the developing world, we analyze the potential and limits of donor-financed management tools aimed at promoting CSR in developing country SMEs. Design/methodology/approach - Using official UN and OECD lists of all multilateral...... and bilateral donor agencies we identified 38 donors that might have produced such CSR tools. We contacted them via e-mail and/or telephone, and conductied an extensive internet search with the aim of identifying whether they had developed management tools aimed at promoting CSR in SMEs in developing countries...

  7. CSR as Aspirational Talk

    DEFF Research Database (Denmark)

    Christensen, Lars Thøger; Morsing, Mette; Thyssen, Ole

    2013-01-01

    and that such discrepancies have the potential to stimulate CSR improvements. We draw on a research tradition that regards communication as performative to challenge the conventional assumption that CSR communication is essentially superficial, as opposed to CSR action. In addition, we extend notions of organizational......Most writings on corporate social responsibility (CSR) treat lack of consistency between organizational CSR talk and action as a serious problem that needs to be eliminated. In this article, we argue that differences between words and action are not necessarily a bad thing...... hypocrisy to argue that aspirational CSR talk may be an important resource for social change, even when organizations do not fully live up to their aspirations....

  8. Three Tiers of CSR

    DEFF Research Database (Denmark)

    Aggerholm, Helle Kryger; Trapp, Leila

    2014-01-01

    Heightened concern with global issues has led to shifts in corporate social responsibility (CSR) programs. To capture the distinct nature of this global focus, researchers have developed a three-generation CSR typology. In this paper we first evaluate the usefulness of this typology...... for understanding corporate approaches to CSR by examining how several companies position themselves thematically in CEO introductions to sustainability reports. On the basis of this, we then evaluate the practical value of this typology for assisting those who work with CSR strategy. The analysis revealed...... expressions of all three CSR generations, with third generation thinking being apparent, but not dominant. It also verified that the three-generation CSR typology can be an instructive means of both evaluating as well as framing a company’s approach to sustainability, though with modifications. On the basis...

  9. Communicating CSR is More Challenging than Paying CSR

    OpenAIRE

    Supriya Motwani

    2012-01-01

    In spite of the research on CSR being 50 years old, there is still no common definition of CSR. This field of study is not only theoretical & conceptually poor, but is also empirically unexplored. This is also true for CSR communication. CSR activities need to communicate because they may influence opinion leader’s behavior regarding a target organization. This potential for exploring CSR communication has lead us to develop a study that focuses on CSR communication practice & it’s challenges...

  10. Alignment for CSR

    International Nuclear Information System (INIS)

    Cooled Storage Ring of Heavy Ion Research Facility in Lanzhou (HIRFL-CSR) belongs to China great scientific project in China. The alignment for it is very difficult because of very large area and very high accuracy. For the special case in HIRFL-CSR, some new methods and new instruments are used, including the construction of survey control network, the usage of laser tracker, and CSR alignment database system with applications developed to store and analyze data. The author describes the whole procedure of CSR alignment

  11. Torm's CSR-karakter

    OpenAIRE

    Pyke, Niklas Bruhn

    2012-01-01

    This study investigate how the CSR of an organisation can be viewed in terms of its underlying CSR character. The study is examining the development of Torm´s CSR character, by selecting two specific parameters: identity orientation and strategic consistency. With the focus on Torm´s identity orientation, the study interprets how Torm relate to its stakeholders in their CSR-reports from 2007-2012 and concludes, that Torm have changed their orientation from a hybrid of collectivistic and indiv...

  12. Reporting consistently on CSR

    DEFF Research Database (Denmark)

    Thomsen, Christa; Nielsen, Anne Ellerup

    2006-01-01

    This chapter first outlines theory and literature on CSR and Stakeholder Relations focusing on the different perspectives and the contextual and dynamic character of the CSR concept. CSR reporting challenges are discussed and a model of analysis is proposed. Next, our paper presents the results...... of a case study showing that companies use different and not necessarily consistent strategies for reporting on CSR. Finally, the implications for managerial practice are discussed. The chapter concludes by highlighting the value and awareness of the discourse and the discourse types adopted...

  13. CSR schemes in agribusiness

    DEFF Research Database (Denmark)

    Pötz, Katharina Anna; Haas, Rainer; Balzarova, Michaela

    2013-01-01

    of schemes that can be categorized on focus areas, scales, mechanisms, origins, types and commitment levels. Research limitations/implications – The findings contribute to conceptual and empirical research on existing models to compare and analyse CSR standards. Sampling technique and depth of analysis limit...... this research, but the authors offer insights into patterns of CSR standard development in agribusiness and point to important research avenues. Practical implications – These findings can help agribusiness managers to select and analyse CSR standards and other forms of CSR guidance. Social implications...... – Standard and guidance setting activities can be expected to have real-life effects on CSR outcomes. These effects need to be better understood by policy makers and stakeholders. The authors' meta-analysis contributes to further research on who or what influences standard development. Originality...

  14. CSR in Afghanistan

    DEFF Research Database (Denmark)

    Azizi, Sameer; Jamali, Dima

    2016-01-01

    explicit CSR themes. Research limitations/implications: – The findings are based on CSR practices that are explicitly stated and do not include informal and/or implicit business-society practices in such contexts. Originality/value: – This paper combines the literature on areas of limited statehood......Purpose: – The purpose of this paper is to explain the emergence of CSR in Afghanistan as a novel context in the South-Asian CSR debate. Design/methodology/approach: – The findings of the paper are based on case studies of four corporations in the Afghan mobile telecommunications industry. Multiple...... space for manoeuvring for non-state actors to play a pivotal role in business-society relations. The paper highlights that the CSR practices are driven by the multi-level organisational field that through a unique blend of global coercive, mimetic and normative pressures lead to convergence around...

  15. Cancer incidence in Italian contaminated sites

    Directory of Open Access Journals (Sweden)

    Pietro Comba

    2014-06-01

    Full Text Available INTRODUCTION. The incidence of cancer among residents in sites contaminated by pollutants with a possible health impact is not adequately studied. In Italy, SENTIERI Project (Epidemiological study of residents in National Priority Contaminated Sites, NPCSs was implemented to study major health outcomes for residents in 44 NPCSs. METHODS. The Italian Association of Cancer Registries (AIRTUM records cancer incidence in 23 NPCSs. For each NPCSs, the incidence of all malignant cancers combined and 35 cancer sites (coded according to ICD-10, was analysed (1996-2005. The observed cases were compared to the expected based on age (5-year period,18 classes, gender, calendar period (1996-2000; 2001-2005, geographical area (North-Centre and Centre-South and cancer sites specific rates. Standardized Incidence Ratios (SIR with 90% Confidence Intervals were computed. RESULTS. In both genders an excess was observed for overall cancer incidence (9% in men and 7% in women as well as for specific cancer sites (colon and rectum, liver, gallbladder, pancreas, lung, skin melanoma, bladder and Non Hodgkin lymphoma. Deficits were observed for gastric cancer in both genders, chronic lymphoid leukemia (men, malignant thyroid neoplasms, corpus uteri and connective and soft-tissue tumours and sarcomas (women. DISCUSSION. This report is, to our knowledge, the first one on cancer risk of residents in NPCSs. The study, although not aiming to estimate the cancer burden attributable to the environment as compared to occupation or life-style, supports the credibility of an etiologic role of environmental exposures in contaminated sites. Ongoing analyses focus on the interpretation of risk factors for excesses of specific cancer types overall and in specific NPCSs in relation to the presence of carcinogenic pollutants.

  16. Communicating CSR is More Challenging than Paying CSR

    Directory of Open Access Journals (Sweden)

    Supriya Motwani

    2012-06-01

    Full Text Available In spite of the research on CSR being 50 years old, there is still no common definition of CSR. This field of study is not only theoretical & conceptually poor, but is also empirically unexplored. This is also true for CSR communication. CSR activities need to communicate because they may influence opinion leader’s behavior regarding a target organization. This potential for exploring CSR communication has lead us to develop a study that focuses on CSR communication practice & it’s challenges. Communicating CSR means not only communicating a company’s behavior through standards or codes of conduct, but also communicating about very long projects. From this argument, we draw the conclusion that conscious communication of CSR is difficult, but necessary. Since creating stakeholder awareness & managing stakeholder attributes are key prerequisite for reaping the strategic benefits of any business initiative, it is imperative for board members & senior executives instituting a CSR program to have deeper understanding of key issues related to CSR communication. These include questions surrounding what to communicate, where to communicate, as well as an understanding of the factors that influence the effectiveness of a CSR campaign. Communicating CSR is a very delicate matter, & a key challenge of CSR communication is how to minimize stakeholder skepticism & to convey intrinsic motives in a company’s CSR activities. This paper explores the various communication channels for CSR, their communication objectives, & challenges posed by the companies for communicating CSR.

  17. Complex regulation of the global regulatory gene csrA: CsrA-mediated translational repression, transcription from five promoters by Eσ70 and EσS, and indirect transcriptional activation by CsrA

    OpenAIRE

    Yakhnin, Helen; Yakhnin, Alexander V.; Baker, Carol S.; Sineva, Elena; Berezin, Igor; Romeo, Tony; Babitzke, Paul

    2011-01-01

    CsrA of Escherichia coli is an RNA binding protein that globally regulates gene expression by repressing translation and/or altering the stability of target transcripts. Here we explored mechanisms that control csrA expression. Four CsrA binding sites were predicted upstream of the csrA initiation codon, one of which overlapped its Shine-Dalgarno sequence. Results from gel shift, footprint, toeprint and in vitro translation experiments indicate that CsrA binds to these four sites and represse...

  18. Analyza CSR v podniku

    OpenAIRE

    Kasl, Michael

    2015-01-01

    The Bachelor thesis deals with the analysis of corporate social responsibility (CSR) at PwC. The thesis is divided into theoretical and practical part. The theoretical part explains basic concepts concerning the corporate social responsibility, as well as the history of CSR and reasons for implementing it. The practical part of the thesis is focused on the PwC network, mainly on PwC Czech Republic. Mentioned CSR activities done by PwC CZ and international strategy are used for comparison and ...

  19. The Ribonucleoprotein Csr Network

    Directory of Open Access Journals (Sweden)

    Ethel Seyll

    2013-11-01

    Full Text Available Ribonucleoprotein complexes are essential regulatory components in bacteria. In this review, we focus on the carbon storage regulator (Csr network, which is well conserved in the bacterial world. This regulatory network is composed of the CsrA master regulator, its targets and regulators. CsrA binds to mRNA targets and regulates translation either negatively or positively. Binding to small non-coding RNAs controls activity of this protein. Expression of these regulators is tightly regulated at the level of transcription and stability by various global regulators (RNAses, two-component systems, alarmone. We discuss the implications of these complex regulations in bacterial adaptation.

  20. Strategisk CSR i store virksomheder

    OpenAIRE

    Færch, Maya Lauridsen

    2013-01-01

    This thesis examines the institutionalization of strategic CSR in large corporations in Denmark. The study focuses on how strategic CSR has become a part of the overall legitimizing paradigms in the Danish society, and whether the use of strategic CSR results in isomorphic tendencies among large corporations in Denmark. Furthermore, it examines how large corporations institutionalize strategic CSR in regards to the integration of strategic CSR in operational activities and the embedment of st...

  1. Religiosity, CSR attitudes, and CSR behavior : An empirical study of executives’ religiosity and CSR

    NARCIS (Netherlands)

    Mazereeuw, C.; Graafland, J.J.; Kaptein, M.

    2014-01-01

    In this paper, we examine the relationship between Christian religiosity, attitudes towards corporate social responsibility (CSR), and CSR behavior of executives. We distinguish four types of CSR attitudes and five types of CSR behavior. Based on empirical research conducted among 473 Dutch executiv

  2. CSR as Imperialism

    DEFF Research Database (Denmark)

    Lund-Thomsen, Peter; Khan, Farzad Rafi

    2011-01-01

    the interpretations given to Western-based CSR initiatives by local manufacturers. Data from two qualitative research projects on CSR initiatives in the soccer ball industry of Sialkot, Pakistan, are utilized to explore this issue in an inductive and exploratory manner. The article suggests that many soccer ball......The voices of local manufacturers have largely been overlooked in academic and policy debates on corporate social responsibility (CSR) in the developing world. This article makes a contribution towards filling this gap in the literature by explicitly taking a phenomenological approach that maps...... manufacturers in Sialkot perceive CSR as part of the wider historic project of Western imperialism in the developing world through which economic resources are extracted from local manufacturers while their perceptions of what constitutes socially responsible behaviour are delegitimized. This counter...

  3. CSR in Industrial Clusters

    DEFF Research Database (Denmark)

    Lund-Thomsen, Peter; Pillay, Renginee G.

    2012-01-01

    Purpose – The paper seeks to review the literature on CSR in industrial clusters in developing countries, identifying the main strengths, weaknesses, and gaps in this literature, pointing to future research directions and policy implications in the area of CSR and industrial cluster development...... in this field and their comments incorporated in the final version submitted to Corporate Governance. Findings – The article traces the origins of the debate on industrial clusters and CSR in developing countries back to the early 1990s when clusters began to be seen as an important vehicle for local economic...... development in the South. At the turn of the millennium the industrial cluster debate expanded as clusters were perceived as a potential source of poverty reduction, while their role in promoting CSR among small and medium-sized enterprises began to take shape from 2006 onwards. At present, there is still...

  4. CSR at Daimler

    OpenAIRE

    Geipel, Teresa

    2013-01-01

    Social responsibility of companies is a topic which has been more and more discussed during the last years. A lot of initiatives were started by the headline of Corporate Social Responsibility. But are these initiatives just window dressing or have employees really internalized the importance of Corporate Social Responsibility (CSR) and act according to the corporate principles? This project investigates on the CSR strategy and its implementation at the German multinational cooperation Daimle...

  5. BAT, CSR and Lobbying

    OpenAIRE

    Williams, Sarah

    2008-01-01

    Due to the nature of their product, tobacco companies face much criticism from many fronts, particularly the media and NGOs. This public criticism has meant tobacco companies strive to implement sound and commendable CSR principles, initiatives, and codes, often voluntarily reporting on their CSR or sustainability activities. Tobacco companies have also faced criticism regarding their lobbying practices since the 1950s and onwards. Many commentators feel they should be excluded from consu...

  6. CSR, tax and development

    OpenAIRE

    Jenkins, Rhys; Newell, P.

    2013-01-01

    This article explores and critically examines the connections between tax and development on the one hand and tax and corporate social responsibility (CSR) on the other. It does so because, while there is increasing recognition of the importance of taxation to efforts to resource the state and to finance ways of tackling poverty, there is a surprising lack of attention to tax avoidance and evasion as a CSR issue for transnational corporations operating in the South, even among those companies...

  7. CSR, H&M

    OpenAIRE

    Krohn Bjerggaard Hansen, Thomas; Halveg Olesen, Emil; Mejdahl Jeppesen, Peter

    2016-01-01

    This assignment deals with Corporate Social Responsibility (CSR), how the term and the interpretation of it have developed through time. Furthermore, the assignment analyze discus how to place the responsibility and in which scope it is fair to place it within. Is it the companies, the consumers or the governments’ responsibility, or is it a mix of the three characters? In the first analysis, we use already existing empirical data to describe the history of CSR, how the term theoretically ...

  8. Interaction of CSR1 with XIAP reverses inhibition of caspases and accelerates cell death.

    Science.gov (United States)

    Zheng, Zhong-Liang; Tan, Lang-Zhu; Yu, Yan P; Michalopoulos, George; Luo, Jian-Hua

    2012-08-01

    Cellular Stress Response 1 (CSR1) is a tumor suppressor gene that is located at 8p21, a region that is frequently deleted in prostate cancer as well as a variety of human malignancies. Previous studies have indicated that the expression of CSR1 induces cell death. In this study, we found that CSR1 interacts with X-linked Inhibitor of Apoptosis Protein (XIAP), using yeast two-hybrid screening analyses. XIAP overexpression has been found in many human cancers, and forced expression of XIAP blocks apoptosis. Both in vitro and in vivo analyses indicated that the C-terminus of CSR1 binds XIAP with high affinity. Through a series of in vitro recombinant protein-binding analyses, the XIAP-binding motif in CSR1 was determined to include amino acids 513 to 572. Targeted knock-down of XIAP enhanced CSR1-induced cell death, while overexpression of XIAP antagonized CSR1 activity. The binding of CSR1 with XIAP enhanced caspase-9 and caspase-3 protease activities, and CSR1-induced cell death was dramatically reduced on expression of a mutant CSR1 that does not bind XIAP. However, a XIAP mutant that does not interact with caspase-9 had no impact on CSR1-induced cell death. These results suggest that cell death is induced when CSR1 binds XIAP, preventing the interaction of XIAP with caspases. Thus, this study may have elucidated a novel mechanism by which tumor suppressors induce cell death. PMID:22683311

  9. Conceptions of CSR in Japan

    DEFF Research Database (Denmark)

    Lystbæk, Christian Tang

    2014-01-01

    The objective of this paper is to advance an analysis of different conceptions of CSR in Japan after the Fukushima accident. The literature on CSR suggests that CSR is a complex term that has been open to a variety of interpretations. Until recently, CSR was mainly incorporated into Japanese comp...... challenge for CSR in Japan is to deal with the preconceptions about the nature of business activities amongst managers, politicians, and other CSR agents.......The objective of this paper is to advance an analysis of different conceptions of CSR in Japan after the Fukushima accident. The literature on CSR suggests that CSR is a complex term that has been open to a variety of interpretations. Until recently, CSR was mainly incorporated into Japanese...... concerns have raised crucial questions about environmental issues with regards to CSR. How do Japanese companies incorporate environmental issues into their CSR aims and achievements? What is the next strategic challenge for CSR in Japan? This paper will analyze the conceptualization of CSR in TEPCO...

  10. Embedding CSR at Burckhardt Compression

    OpenAIRE

    Nimruji Jammulamadaka; Dinesh B. Khonde

    2011-01-01

    This case deals with a medium-sized engineering company's experiences with initiating CSR. It covers aspects like the rationale for CSR, its relationship with strategy, participation in CSR and speed breakers on the path to building a CSR culture in the company. After sustained growth over a few years, the top management has decided to look beyond profits and embarked on CSR. They allocated 2% of their PBT to their Trust to oversee CSR activities. They began the activities about one and a hal...

  11. In silico identification and experimental characterization of regulatory elements controlling the expression of the Salmonella csrB and csrC genes.

    Science.gov (United States)

    Martínez, Luary C; Martínez-Flores, Irma; Salgado, Heladia; Fernández-Mora, Marcos; Medina-Rivera, Alejandra; Puente, José L; Collado-Vides, Julio; Bustamante, Víctor H

    2014-01-01

    The small RNAs CsrB and CsrC of Salmonella indirectly control the expression of numerous genes encoding widespread cellular functions, including virulence. The expression of csrB and csrC genes, which are located in different chromosomal regions, is coordinated by positive transcriptional control mediated by the two-component regulatory system BarA/SirA. Here, we identified by computational analysis an 18-bp inverted repeat (IR) sequence located far upstream from the promoter of Salmonella enterica serovar Typhimurium csrB and csrC genes. Deletion analysis and site-directed mutagenesis of the csrB and csrC regulatory regions revealed that this IR sequence is required for transcriptional activation of both genes. Protein-DNA and protein-protein interaction assays showed that the response regulator SirA specifically binds to the IR sequence and provide evidence that SirA acts as a dimer. Interestingly, whereas the IR sequence was essential for the SirA-mediated expression of csrB, our results revealed that SirA controls the expression of csrC not only by binding to the IR sequence but also by an indirect mode involving the Csr system. Additional computational, biochemical, and genetic analyses demonstrated that the integration host factor (IHF) global regulator positively controls the expression of csrB, but not of csrC, by interacting with a sequence located between the promoter and the SirA-binding site. These findings contribute to the better understanding of the regulatory mechanism controlling the expression of CsrB and CsrC.

  12. In silico identification and experimental characterization of regulatory elements controlling the expression of the Salmonella csrB and csrC genes.

    Science.gov (United States)

    Martínez, Luary C; Martínez-Flores, Irma; Salgado, Heladia; Fernández-Mora, Marcos; Medina-Rivera, Alejandra; Puente, José L; Collado-Vides, Julio; Bustamante, Víctor H

    2014-01-01

    The small RNAs CsrB and CsrC of Salmonella indirectly control the expression of numerous genes encoding widespread cellular functions, including virulence. The expression of csrB and csrC genes, which are located in different chromosomal regions, is coordinated by positive transcriptional control mediated by the two-component regulatory system BarA/SirA. Here, we identified by computational analysis an 18-bp inverted repeat (IR) sequence located far upstream from the promoter of Salmonella enterica serovar Typhimurium csrB and csrC genes. Deletion analysis and site-directed mutagenesis of the csrB and csrC regulatory regions revealed that this IR sequence is required for transcriptional activation of both genes. Protein-DNA and protein-protein interaction assays showed that the response regulator SirA specifically binds to the IR sequence and provide evidence that SirA acts as a dimer. Interestingly, whereas the IR sequence was essential for the SirA-mediated expression of csrB, our results revealed that SirA controls the expression of csrC not only by binding to the IR sequence but also by an indirect mode involving the Csr system. Additional computational, biochemical, and genetic analyses demonstrated that the integration host factor (IHF) global regulator positively controls the expression of csrB, but not of csrC, by interacting with a sequence located between the promoter and the SirA-binding site. These findings contribute to the better understanding of the regulatory mechanism controlling the expression of CsrB and CsrC. PMID:24187088

  13. CSR1 induces cell death through inactivation of CPSF3.

    Science.gov (United States)

    Zhu, Z-H; Yu, Y P; Shi, Y-K; Nelson, J B; Luo, J-H

    2009-01-01

    CSR1 (cellular stress response 1), a newly characterized tumor-suppressor gene, undergoes hypermethylation in over 30% of prostate cancers. Re-expression of CSR1 inhibits cell growth and induces cell death, but the mechanism by which CSR1 suppresses tumor growth is not clear. In this study, we screened a prostate cDNA library using a yeast two-hybrid system and found that the cleavage and polyadenylation-specific factor 3 (CPSF3), an essential component for converting heteronuclear RNA to mRNA, binds with high affinity to the CSR1 C terminus. Further analyses determined that the binding motifs for CPSF3 are located between amino acids 440 and 543. The interaction between CSR1 and CPSF3 induced CPSF3 translocation from the nucleus to the cytoplasm, resulting in inhibition of polyadenylation both in vitro and in vivo. Downregulation of CPSF3 using small interfering RNA induced cell death in a manner similar to CSR1 expression. A CSR1 mutant unable to bind to CPSF3 did not alter CPSF3 subcellular distribution, did not inhibit its polyadenylation activity and did not induce cell death. In summary, CSR1 appears to induce cell death through a novel mechanism by hijacking a critical RNA processing enzyme. PMID:18806823

  14. Governmentalities of CSR

    DEFF Research Database (Denmark)

    Vallentin, Steen

    2015-01-01

    This paper investigates the roles that Danish government has played in the development of corporate social responsibility (CSR). Denmark has emerged as a first mover among the Scandinavian countries when it comes to CSR. We argue that government has played a pivotal role in making this happen...... by a lack of common direction and that we need to approach it on such terms. In order to provide a critical account of ‘the Danish model’ we apply a governmentality perspective that allows us to stress political difference. We argue that Danish government policy consists of three distinct regimes......, and that this reflects strong traditions of regulation, corporatism and active state involvement. However, there is no unitary “Danish model of CSR” being promoted by government. Although Danish society is often associated with a model of consensus, our claim is that Danish government policy on CSR is characterized...

  15. Campylobacter jejuni CsrA complements an Escherichia coli csrA mutation for the regulation of biofilm formation, motility and cellular morphology but not glycogen accumulation

    Directory of Open Access Journals (Sweden)

    Fields Joshua A

    2012-10-01

    Full Text Available Abstract Background Although Campylobacter jejuni is consistently ranked as one of the leading causes of bacterial diarrhea worldwide, the mechanisms by which C. jejuni causes disease and how they are regulated have yet to be clearly defined. The global regulator, CsrA, has been well characterized in several bacterial genera and is known to regulate a number of independent pathways via a post transcriptional mechanism, but remains relatively uncharacterized in the genus Campylobacter. Previously, we reported data illustrating the requirement for CsrA in several virulence related phenotypes of C. jejuni strain 81–176, indicating that the Csr pathway is important for Campylobacter pathogenesis. Results We compared the Escherichia coli and C. jejuni orthologs of CsrA and characterized the ability of the C. jejuni CsrA protein to functionally complement an E. coli csrA mutant. Phylogenetic comparison of E. coli CsrA to orthologs from several pathogenic bacteria demonstrated variability in C. jejuni CsrA relative to the known RNA binding domains of E. coli CsrA and in several amino acids reported to be involved in E. coli CsrA-mediated gene regulation. When expressed in an E. coli csrA mutant, C. jejuni CsrA succeeded in recovering defects in motility, biofilm formation, and cellular morphology; however, it failed to return excess glycogen accumulation to wild type levels. Conclusions These findings suggest that C. jejuni CsrA is capable of efficiently binding some E. coli CsrA binding sites, but not others, and provide insight into the biochemistry of C. jejuni CsrA.

  16. Experiencing CSR in Asia

    DEFF Research Database (Denmark)

    Kampf, Constance Elizabeth

    2014-01-01

    This paper focuses on Corporate Social Responsibility (CSR) as strongly linked to expectations for corporations in the cultural con- texts in which they operate. Using an approach based in a macro-level for socio-technical design, it examines the interaction between digital activist efforts to (r...... into question the via- bility of CSR practices mediated by policy and NGOs, because busi- nesses appear to be simply adopting mediators’ perspectives to avoid a crisis rather than a building a strategy based on critical engagement with the issues....

  17. CSR Communication & SMEs

    OpenAIRE

    Eliasson, Malin; Smajovic, Senida

    2009-01-01

      Purpose: The purpose of this thesis is to investigate how SMEs in the Småland region define and communicate their CSR activities towards their stakeholders. Background: Corporate social responsbility is a topic that is widely discussed today. In many cases the CSR agenda has been adopted by many large corporations. However there is a demand from governmental bodies to spread this agenda further to include and engage small-to-medium enterprises (SMEs). The main reason for this approach is du...

  18. Regulation of bacterial virulence by Csr (Rsm) systems.

    Science.gov (United States)

    Vakulskas, Christopher A; Potts, Anastasia H; Babitzke, Paul; Ahmer, Brian M M; Romeo, Tony

    2015-06-01

    Most bacterial pathogens have the remarkable ability to flourish in the external environment and in specialized host niches. This ability requires their metabolism, physiology, and virulence factors to be responsive to changes in their surroundings. It is no surprise that the underlying genetic circuitry that supports this adaptability is multilayered and exceedingly complex. Studies over the past 2 decades have established that the CsrA/RsmA proteins, global regulators of posttranscriptional gene expression, play important roles in the expression of virulence factors of numerous proteobacterial pathogens. To accomplish these tasks, CsrA binds to the 5' untranslated and/or early coding regions of mRNAs and alters translation, mRNA turnover, and/or transcript elongation. CsrA activity is regulated by noncoding small RNAs (sRNAs) that contain multiple CsrA binding sites, which permit them to sequester multiple CsrA homodimers away from mRNA targets. Environmental cues sensed by two-component signal transduction systems and other regulatory factors govern the expression of the CsrA-binding sRNAs and, ultimately, the effects of CsrA on secretion systems, surface molecules and biofilm formation, quorum sensing, motility, pigmentation, siderophore production, and phagocytic avoidance. This review presents the workings of the Csr system, the paradigm shift that it generated for understanding posttranscriptional regulation, and its roles in virulence networks of animal and plant pathogens.

  19. Regulation of bacterial virulence by Csr (Rsm) systems.

    Science.gov (United States)

    Vakulskas, Christopher A; Potts, Anastasia H; Babitzke, Paul; Ahmer, Brian M M; Romeo, Tony

    2015-06-01

    Most bacterial pathogens have the remarkable ability to flourish in the external environment and in specialized host niches. This ability requires their metabolism, physiology, and virulence factors to be responsive to changes in their surroundings. It is no surprise that the underlying genetic circuitry that supports this adaptability is multilayered and exceedingly complex. Studies over the past 2 decades have established that the CsrA/RsmA proteins, global regulators of posttranscriptional gene expression, play important roles in the expression of virulence factors of numerous proteobacterial pathogens. To accomplish these tasks, CsrA binds to the 5' untranslated and/or early coding regions of mRNAs and alters translation, mRNA turnover, and/or transcript elongation. CsrA activity is regulated by noncoding small RNAs (sRNAs) that contain multiple CsrA binding sites, which permit them to sequester multiple CsrA homodimers away from mRNA targets. Environmental cues sensed by two-component signal transduction systems and other regulatory factors govern the expression of the CsrA-binding sRNAs and, ultimately, the effects of CsrA on secretion systems, surface molecules and biofilm formation, quorum sensing, motility, pigmentation, siderophore production, and phagocytic avoidance. This review presents the workings of the Csr system, the paradigm shift that it generated for understanding posttranscriptional regulation, and its roles in virulence networks of animal and plant pathogens. PMID:25833324

  20. CSR1 induces cell death through inactivation of CPSF3

    OpenAIRE

    Zhu, Z-H; Yu, YP; Shi, Y-K; Nelson, JB; Luo, J-H

    2008-01-01

    CSR1 (cellular stress response 1), a newly characterized tumor-suppressor gene, undergoes hypermethylation in over 30% of prostate cancers. Re-expression of CSR1 inhibits cell growth and induces cell death, but the mechanism by which CSR1 suppresses tumor growth is not clear. In this study, we screened a prostate cDNA library using a yeast two-hybrid system and found that the cleavage and polyadenylation-specific factor 3 (CPSF3), an essential component for converting heteronuclear RNA to mRN...

  1. Providing Southern Perspectives on CSR

    OpenAIRE

    Jeppesen, Søren; Kothuis, Bas

    2014-01-01

    The article seeks to contribute to the SMEs and CSR literature in developing countries by providing; a) a ‘Southern’ SME perspective, which includes the voices of managers and workers, b) a perspective of CSR, which opens up to informal CSR practices that SMEs undertake, and c) an analysis of the key institutional issues affecting the CSR practices of SMEs. It presents perceptions of CSR practices among 21 SMEs in the garment industry in South Africa, based on 40 interviews with managers and ...

  2. Can CSR be controlled?

    DEFF Research Database (Denmark)

    Kampf, Constance

    2009-01-01

    Associate Professor Constance Kampf talks about whether companies can control CSR or not, and she talks about the possible implications it can have if companies fail to live up their responsibilties. In that sense companies needs to consider the impact of the internet. She also gives advice on how...

  3. CSR as Corporate Political Activity

    DEFF Research Database (Denmark)

    Morsing, Mette; Roepstorff, Anne

    2015-01-01

    In this article, we develop a conceptual framework to understand how a company’s CSR identity becomes defined as a political activity destabilizing the strong identity–image relations. We draw on theories of political CSR and organizational identity–image relations to study how CSR emerges...... as a corporate political activity in a context where the corporate CSR work is first appreciated and later critiqued by the public in the wake of socio-political events. We analyse the micro-organizational processes in the context of macro-political level changes, and we refer to this as the ‘identity....... In this process, IKEA’s CSR identity becomes defined as a political and non-neutral activity. Our article contributes by bringing attention to the organizational level dynamics of political CSR by offering a conceptualization of how global and local socio-political events may disturb the alignment between CSR...

  4. CSR Model Implementation from School Stakeholder Perspectives

    Science.gov (United States)

    Herrmann, Suzannah

    2006-01-01

    Despite comprehensive school reform (CSR) model developers' best intentions to make school stakeholders adhere strictly to the implementation of model components, school stakeholders implementing CSR models inevitably make adaptations to the CSR model. Adaptations are made to CSR models because school stakeholders internalize CSR model practices…

  5. CSR : Structure for Responsibility

    OpenAIRE

    Adestam, Carina; Gunnmo, Sofia

    2008-01-01

    Many organisational flaws are consequences of unsuitable structure arrangements that do not support the organisation in its work towards goal accomplishment. The appropriateness of the structure is determined by how well it allows the organisation to respond to the environment in which it is active. Furthermore, an organisation is divided into parts with their own requirements on the structure. CSR is a concept that enables for a wider perspective of how to conduct business, thereby strengthe...

  6. HIRFL-CSR complex

    International Nuclear Information System (INIS)

    The construction and commissioning of HIRFL-CSR were finished in 2007. From 2000 to 2005 the subsystem and key devices of CSR were successfully fabricated, such as magnet, power supply, UHV system, e-cooler, electric-static deflector with the septum of 0.1 mm, and the fast-pulse kicker with the rise time of 150 ns. After that the CSR commissioning activities were performed in 2006 and 2007, including the accumulation of those heavy ions of C, Ar, Kr and Xe by the combination of stripping injection (STI) or multiple multi-turn injection (MMI) and e-cooling with a hollow e-beam, wide energy-range synchrotron ramping by changing the RF harmonic-number at mid-energy, the beam stacking in the experimental ring CSRe, the RIBs mass-measurement with the isochronous-mode in CSRe by using the time-of-flight method, and the ion beam slow-extraction from CSRm. (authors)

  7. CSR, SMEs and Social Capital

    DEFF Research Database (Denmark)

    Murillo, David; Vallentin, Steen

    2012-01-01

    behind these CSR actions must reflect their essentially pragmatic nature. Actions are linked to social values but also, more importantly, to the nature of the competitive environment c) Business ethics must seek common ground with other more sociological disciplines if it is to explain the reasons behind......This paper is a response to the opening of new lines of research on CSR and SMEs (Thompson & Smith, 1991; Spence, 1999; Moore & Smith, 2006; Spence, 2007). It seeks to explore the business case for CSR in this corporate segment. The paper, which is based on four case studies of medium-sized firms...... in the automotive sector, took the distinctive approach of trying to understand the nature of CSR-like activities developed not by best-in-class CSR-driven companies but by purely competitiveness-driven firms. The case studies provide explicit evidence that the CSR activities of SMEs and the notion of social...

  8. Space charge effects of CSR

    International Nuclear Information System (INIS)

    Cooler Storage Ring (CSR), and upgrading program planned at the Heavy Ion Research Facility in Lanzhou (HIRFL), will supply beams with higher quality and intensity. Space charge effects should be considered due to this magnitude of intensity in CSR. The concept and some phenomena of space charge effects are discussed. Space charge intensity limit and space charge tune shift of normal CSR operation are given. It is of significance for the construction and operation of the future facility

  9. CSR-kommunikation med omtanke

    OpenAIRE

    Skovgaard, Maja; Felbo-Kolding, Mia; Larsen, Peter Hjorth

    2007-01-01

    Strategic Corporate Social Responsibility communication has become a big challenge for companies today. Increasingly, investors, NGO’s, B2B customers and consumers want the companies to engage in CSR activities and to document and communicate them. But CSR communication is complicated by the fact that stakeholders not always want to hear about the companies’ efforts. Companies are often perceived as self-absorbed and are met with scepticism when they communicate their CSR efforts. In this pro...

  10. Cancer of the Testis

    Science.gov (United States)

    ... 1975-2013 Browse the Tables and Figures Access CSR Contents in PDF Generate Custom Reports About the ... Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2013/ , based on November 2015 SEER data ...

  11. Cancer of the Anus

    Science.gov (United States)

    ... 1975-2013 Browse the Tables and Figures Access CSR Contents in PDF Generate Custom Reports About the ... Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2013/ , based on November 2015 SEER data ...

  12. Cancer of the Larynx

    Science.gov (United States)

    ... 1975-2013 Browse the Tables and Figures Access CSR Contents in PDF Generate Custom Reports About the ... Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2013/ , based on November 2015 SEER data ...

  13. Providing Southern Perspectives on CSR

    DEFF Research Database (Denmark)

    Jeppesen, Søren; Kothuis, Bas

    The article seeks to contribute to the SMEs and CSR literature in developing countries by providing; a) a ‘Southern’ SME perspective, which includes the voices of managers and workers, b) a perspective of CSR, which opens up to informal CSR practices that SMEs undertake, and c) an analysis of the...... are found to be important factors in explaining the CSR perceptions and level of practices. It is suggested that future research investigate the role of informal practices further and explore the role of institutional theory.......The article seeks to contribute to the SMEs and CSR literature in developing countries by providing; a) a ‘Southern’ SME perspective, which includes the voices of managers and workers, b) a perspective of CSR, which opens up to informal CSR practices that SMEs undertake, and c) an analysis...... of the key institutional issues affecting the CSR practices of SMEs. It presents perceptions of CSR practices among 21 SMEs in the garment industry in South Africa, based on 40 interviews with managers and 19 interviews with workers through the use of qualitative and quantitative interview frameworks...

  14. CSR i et foranderligt samfund

    OpenAIRE

    Meedom, Maria; Stokholm, Helle; Miara, Denice; á Lakjuni, Heidi; Dayyani, Navid

    2012-01-01

    CSR i et foranderligt samfund Dette projekt har fokus på samfundsansvar. I projektet henviser vi løbende til elementer fra Anthony Giddens strukturationsteori og modernitetsanalyse. Vi undersøger hvad der ligger i begrebet CSR og hvordan udviklingen af CSR har været i Danmark. Vi diskuterer de samfundsmæssige konsekvenser af forskellige holdninger til CSR. Dette gør vi ud fra teori af Friedman og Henderson, der ikke mener det er virksomhedernes ansvar og Freeman og Porter & Kramer der arg...

  15. Status of the HIRFL–CSR complex

    International Nuclear Information System (INIS)

    Highlights: • HIRFL is in a very positive state and can provide all ion species with maximum energy to 1 GeV/u (A/q = 2). • Present status of HIRFL complex is given as well as the new progress on operation and improvement. • With emphasize on HIRFL–CSR project, main features realized during the commissioning and operation are described in detail. • The progress on physics experiments and hadron cancer therapy are also presented. -- Abstract: The HIRFL–CSR, as an upgrade of the HIRFL, has been put into operation since 2008. Together with a series of improvements of injector cyclotrons, the HIRFL is in a very good state and can provide all ion species from proton to uranium with energy variable from ion source energy to 1 GeV/u (A/q = 2). Present status of the HIRFL–CSR complex is given. Main features realized during the commissioning and operation are described in detail. The progress on physics experiments and cancer therapy are also presented

  16. Novo Nordisk og CSR

    OpenAIRE

    Skar, Lasse Feilberg; Olsen, Isabella Victoria; Palm, Laura Bechstøfft

    2014-01-01

    Abstract This study is a critical case study that concerns itself with the danish firm Novo Nordisk. The study's main focus is on the CSR-strategy of the firm, and furthermore to investigate following key elements; legitimacy, the power of the media and Michael Porter and Mark Kramer’s theory about shared value. The critical approach to Novo Nordisk and it’s strategy is necessary to the study because, it wish to get real insight in the firm’s strategy. To get part of the insight, an i...

  17. HIRFL-CSR physics program

    International Nuclear Information System (INIS)

    The research activities at HIRFL-CSR cover the fields of the radio-biology, material science, atomic physics, and nuclear physics. This talk will mainly concentrate on the program on nuclear physics with the existing and planned experimental setups at HIRFL-CSR. (author)

  18. Cyclotron subharmonics resonant (CSR) heating

    International Nuclear Information System (INIS)

    Corresponding to the experiment done with the JIPPT-II-U device [Phys. Rev. Lett. 54, 2339 (1985)], the cyclotron subharmonics resonant (CSR) heating mechanism is studied using particle simulation codes with an emphasis on the relationship between CSR and the nonlinear Landau damping

  19. CSR-1 Slices a Balance.

    Science.gov (United States)

    Yu, Ruby; Moazed, Danesh

    2016-04-01

    CSR-1 is a germline-expressed C. elegans Argonaute protein essential for viability. In this issue of Cell, Gerson-Gurwitz et al. now demonstrate a role for CSR-1 and its slicer activity in downregulating the levels of maternally deposited mRNAs to fine-tune the expression of proteins with critical roles in embryonic cell divisions. PMID:27058659

  20. Overview on the HIRFL-CSR facility

    International Nuclear Information System (INIS)

    The status of the HIRFL (Heavy Ion Facility in Lanzhou) – Cooler Storage Ring (CSR) at the IMP is reported. The main physics goals at the HIRFL-CSR are the researches on nuclear structure and decay property, EOS of nuclear matter, hadron physics, highly charged atomic physics, high energy density physics, nuclear astrophysics, and applications for cancer therapy, space industries, materials and biology sciences. The HIRFL-CSR is the first ion cooler-storage-ring system in China, which consists of a main ring (CSRm), an experimental ring (CSRe) and a radioactive beam line (RIBLL2). The two existing cyclotrons SFC (K = 70) and SSC (K = 450) are used as its injectors. The 7 MeV/u 12C6+ ions were stored successfully in CSRm with the stripping injection in January 2006. After that, realized were the accelerations of 12C6+, 36Ar18+, 78Kr28+ and 129Xe27+ ions with energies of 1 GeV/u, 1 GeV/u, 450 MeV/u and 235 MeV/u, respectively, including accumulation, electron cooling and acceleration. In 2008, the first two isochronous mass measurement experiments with the primary beams of 36Ar18+ and 78Kr28+ were performed at CSRe with the Δp/p ~ 10-5. (author)

  1. Overview on the Hirfl-Csr Facility

    Science.gov (United States)

    Xiao, G. Q.; Xia, J. W.; Yuan, Y. J.; Mao, R. S.; Zheng, J. H.; Tu, X. L.; Wang, M.; Huang, W. X.; Xu, H. S.; Zhan, W. L.

    The status of the HIRFL (Heavy Ion Facility in Lanzhou) - Cooler Storage Ring (CSR) at the IMP is reported. The main physics goals at the HIRFL-CSR are the researches on nuclear structure and decay property, EOS of nuclear matter, hadron physics, highly charged atomic physics, high energy density physics, nuclear astrophysics, and applications for cancer therapy, space industries, materials and biology sciences. The HIRFL-CSR is the first ion cooler-storage-ring system in China, which consists of a main ring (CSRm), an experimental ring (CSRe) and a radioactive beam line (RIBLL2). The two existing cyclotrons SFC (K = 70) and SSC (K = 450) are used as its injectors. The 7 MeV/u 12C6+ ions were stored successfully in CSRm with the stripping injection in January 2006. After that, realized were the accelerations of 12C6+, 36Ar18+, 78Kr28+ and 129Xe27+ ions with energies of 1 GeV/u, 1 GeV/u, 450 MeV/u and 235 MeV/u, respectively, including accumulation, electron cooling and acceleration. In 2008, the first two isochronous mass measurement experiments with the primary beams of 36Ar18+ and 78Kr28+ were performed at CSRe with the Δp/p ~ 10-5.

  2. A direct link between the global regulator PhoP and the Csr regulon in Y. pseudotuberculosis through the small regulatory RNA CsrC.

    Science.gov (United States)

    Nuss, Aaron M; Schuster, Franziska; Kathrin Heroven, Ann; Heine, Wiebke; Pisano, Fabio; Dersch, Petra

    2014-01-01

    In this study we investigated the influence of the global response regulator PhoP on the complex regulatory cascade controlling expression of early stage virulence genes of Yersinia pseudotuberculosis via the virulence regulator RovA. Our analysis revealed the following novel features: (1) PhoP activates expression of the CsrC RNA in Y. pseudotuberculosis, leading to activation of RovA synthesis through the CsrABC-RovM cascade, (2) activation of csrC transcription is direct and PhoP is shown to bind to two separate PhoP box-like sites, (3) PhoP-mediated activation results in transcription from two different promoters closely downstream of the PhoP binding sites, leading to two distinct CsrC RNAs, and (4) the stability of the CsrC RNAs differs significantly between the Y. pseudotuberculosis strains YPIII and IP32953 due to a 20 nucleotides insertion in CsrC(IP32953), which renders the transcript more susceptible to degradation. In summary, our study showed that PhoP-mediated influence on the regulatory cascade controlling the Csr system and RovA in Y. pseudotuberculosis varies within the species, suggesting that the Csr system is a focal point to readjust and adapt the genus to different hosts and reservoirs. PMID:24786463

  3. CSR – A MARKETING TOOL?

    OpenAIRE

    MIHALACHE, Silvia-Ştefania

    2011-01-01

    Starting from the idea that investing in CSR creates value not only for the company’s stakeholders, but especially for the company itself, in this article, using secondary data analysis, we try to answer the question: is CSR a sign of responsibility or just a marketing tool for promoting the business?The purpose of this paper is to bring contributions in highlighting the nature of the connection between CSR and Marketing, using the secondary data analyze of the annual reports of some companie...

  4. Integrated reporting with CSR practices

    DEFF Research Database (Denmark)

    Lueg, Klarissa; Lueg, Rainer; Andersen, Karina;

    2016-01-01

    and for controlling CSR implementation. However, the long and technical CSR reports did not effectively communicate EGE’s values and possibilities. We outline how EGE overcame these barriers. Contribution: We suggest that IR implementations depend on the context, and explain why the case company has opted to issue 2...... for CSR after IR became mandatory in Denmark. Methodology: We conduct a case study at the Danish carpet manufacturer EGE. We interpret the case from the perspective of pragmatic constructivism, which focuses on the integration of four dimensions: facts, possibilities, values, and communication. Findings...

  5. CSR in TSL companies

    Directory of Open Access Journals (Sweden)

    Joanna DYCZKOWSKA

    2015-03-01

    Full Text Available TSL companies are characterized by high dynamics of an increase of incomes, and hence increased shipping. Owing to a rational policy in the area of the consolidation of production and distribution, they may boast of a better use of the means of transport. The purpose of this article is to present the activities in the area of the eco-friendly CSR aspect in the activities of TSL companies taking into consideration particularly logistic operators. The research methods used in the study include an analysis of secondary data, observations and comparative analyses. Road transport in the shipping structure comes first and it constitutes 84% of freights. In the year 2009, in Poland greenhouse gas emissions from road transport amounted to 42.5 million tons (4.84% of the EU member states and CO emissions were 41.9 million tons (analogically, 4.83% of environment pollutions in the European Union. This causes an emission of fumes into the atmosphere. The policy of sustainable development pursued by logistic operators under corporate social responsibility is a response to the abovementioned data. They take decisions concerning social and environmental aspects. The activities of TSL companies under CSR need to provide an answer to customer expectations and needs, and they have to cause an increase of competitiveness on the market. The selected four largest logistic operators conduct the following eco-friendly activities on the highest level: fume emission reports and the control of these emissions, transport of hazardous goods (ADR, voluntary services in the scope of environmental protection and cooperation with eco-friendly organizations. There are those activities which call for improvement: a limitation of the emission of fumes, waste management and sewage treatment policy.

  6. Harmonization in CSR reporting: MNEs and global CSR standards

    OpenAIRE

    Fortanier, F.; Kolk, A.; Pinkse, J.

    2011-01-01

    This paper focuses on MNEs’ corporate social responsibility (CSR) reporting, which previous studies have found to exhibit strong country-of-origin effects. It examines whether MNEs’ adherence to global standards (as adopted by e.g. ILO, OECD, UN, ISO) is associated with smaller cross-country differences and less country-of-origin effects in CSR reporting, and whether stringency of standards’ enforcement mechanisms affects reporting harmonization. To test our hypotheses, we collected data on 2...

  7. CSR in Publicly Owned Enterprises

    DEFF Research Database (Denmark)

    Lauesen, Linne Marie

    2011-01-01

    of the opportunities and barriers in CSR in these publicly owned enterprises (POEs). The research question is: why do the opportunities of CSR in POEs seem more beneficial than for normal private businesses, while the barriers seem to slow the progression? The opportunities lie in the closeness to and willingness......Purpose – CSR in water utilities in Denmark faces various challenges in getting to the same level as in private organisations. The water utilities are newly privatised, hybrid organisations that are both professionally and politically driven. The purpose of this paper is an examination...... of the political decision-makers of the city. The barriers to CSR in POEs stem from the legal regulatory framework, which dictates efficiencies, price and cost reductions and limits the ethical investments of the POEs. Design/methodology/approach – The methodology of the paper is a comparative study and analysis...

  8. Interaction of CSR1 with XIAP Reverses Inhibition of Caspases and Accelerates Cell Death

    OpenAIRE

    Zheng, Zhong-Liang; Tan, Lang-Zhu; Yu, Yan P.; Michalopoulos, George; Luo, Jian-Hua

    2012-01-01

    Cellular Stress Response 1 (CSR1) is a tumor suppressor gene that is located at 8p21, a region that is frequently deleted in prostate cancer as well as a variety of human malignancies. Previous studies have indicated that the expression of CSR1 induces cell death. In this study, we found that CSR1 interacts with X-linked Inhibitor of Apoptosis Protein (XIAP), using yeast two-hybrid screening analyses. XIAP overexpression has been found in many human cancers, and forced expression of XIAP bloc...

  9. Health survey on cancers about the Tricastin nuclear site

    International Nuclear Information System (INIS)

    This survey aims at describing the health status of the population around the Tricastin site, and more particularly at determining whether there is a difference between death or cancer occurrence frequencies observed around this site with respect to reference frequencies. It does not aim at assessing the health impact of the site industrial installations. Cancer mortality data, cancer diagnosis data, demographic data, child cancer data, data related to hospital stays in relationship with cancer, long duration hospital stay data, and mortality data are used. Several indicators are defined and used: standardised mortality ratio, standardised hospitalisation ratio. Data are also analysed in terms of location, and socio-demographic categories. It appears that there is no specific health situation for the considered area, except for pancreas cancer for women

  10. Identification of a novel regulatory protein (CsrD) that targets the global regulatory RNAs CsrB and CsrC for degradation by RNase E

    OpenAIRE

    Suzuki, Kazushi; Babitzke, Paul; Kushner, Sidney R.; Romeo, Tony

    2006-01-01

    In Escherichia coli, the global regulatory protein CsrA (carbon store regulator A) binds to leader segments of target mRNAs, affecting their translation and stability. CsrA activity is regulated by two noncoding RNAs, CsrB and CsrC, which act by sequestering multiple CsrA dimers. Here, we describe a protein (CsrD) that controls the degradation of CsrB/C RNAs. The dramatic stabilization of CsrB/C RNAs in a csrD mutant altered the expression of CsrA-controlled genes in a manner predicted from t...

  11. Health survey on cancers about the Tricastin nuclear site; Etude sanitaire sur les cancers autour du site nucleaire du Tricastin

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This survey aims at describing the health status of the population around the Tricastin site, and more particularly at determining whether there is a difference between death or cancer occurrence frequencies observed around this site with respect to reference frequencies. It does not aim at assessing the health impact of the site industrial installations. Cancer mortality data, cancer diagnosis data, demographic data, child cancer data, data related to hospital stays in relationship with cancer, long duration hospital stay data, and mortality data are used. Several indicators are defined and used: standardised mortality ratio, standardised hospitalisation ratio. Data are also analysed in terms of location, and socio-demographic categories. It appears that there is no specific health situation for the considered area, except for pancreas cancer for women

  12. Cancer near potential sites of nuclear installations

    International Nuclear Information System (INIS)

    Mortality and census data for 400 districts of England and Wales were analysed with respect to existing sites of nuclear power stations and sites where the construction of such installations had been considered or had occurred at a later date (potential sites). Excess mortality due to leukaemia and Hodgkin's disease in young people who lived near potential sites was similar to that in young people who lived near existing sites. Areas near existing and potential sites might share unrecognised risk factors other than environmental radiation pollution. (author)

  13. Learning CSR for Sustainable Corporate Advantage

    OpenAIRE

    Kakabadse, Andrew P.; Kakabadse, Nada K.; Linda Lee-Davies

    2014-01-01

    Corporate Social Responsibility (CSR) has become a strategic and operational reality of the business and academic world. Not that the principles of CSR are always respected or that its practice is consistently applied. Bearing in mind the multi-faceted nature of both CSR and the corporate environment, as well as the paradox of what is taught in Higher Education and what is practised within its own walls, this paper provides a learning cyclical pathway to sustainable CSR implementation and pro...

  14. CSR strategie pro firmu Liho Blanice

    OpenAIRE

    Březinová, Ilona

    2012-01-01

    The aim of this thesis is to propose a socially responsible activities, which could a smaller company, like Liho Blanice, deals with and implement them in practice. The theoretical part focuses on the introduction of the concept of CSR, its basic features and principles, as well as the methodology of Standard Responsible Company, and some concepts related to CSR. The next part deals with the application of CSR practices, from initial planning to its measurement. CSR strategies of three global...

  15. Exploring the fit between CSR and innovation

    OpenAIRE

    Steven P. MacGregor; Fontrodona, Joan

    2008-01-01

    An exploration of the fit or space between CSR and innovation is presented, based on the RESPONSE project, a 15-month study involving 60 SMEs throughout Europe. The main practical output of the project was the Social Innovation model, yet a conceptual understanding of CSR and innovation is best advanced through the three hypotheses that constitute the conclusions of the project: H1) The diffusion of CSR should be modelled on the diffusion of innovation; H2) CSR implementation and innovation c...

  16. Towards strategic CSR in the multinational corporations

    DEFF Research Database (Denmark)

    Linneberg, Mai Skjøtt; Thorup-Jensen, Line

    2014-01-01

    CSR is a context-specific phenomenon, which makes working strategically with CSR particularly challenging for multinational corporation as it must allow for the various contexts of operation. Based on the extant literature, this article provides a conceptual presentation of MNC's opportunities...... and a global CSR approach....

  17. CSR:New Engine of Economic Recovery

    Institute of Scientific and Technical Information of China (English)

    Guo Yan

    2010-01-01

    @@ Nowadays, China has more and more focused Corporate Social Responsibility (CSR). From October 2009, more than 600 Chinese companies have released CSR reports. According to statistics from China WTO Tribune, in 2009 China issued a total of 631 CSR reports, 3.73 times more than that released in 2008.

  18. Strategiske CSR partnerskaber - Strategisk anvendelse og intern kommunikativ forankring af CSR partnerskaber i IBM Danmark

    OpenAIRE

    Grimstad, Mie Maja Lütken; Jakobsen, Sofie Damgaard

    2016-01-01

    This thesis examines the strategic use of CSR partnerships and the anchoring in the organization using internal CSR communication. There is a known paradox in communicating CSR externally, since businesses often face distrust from stakeholders. On the basis of the conviction that external CSR communication has to start with an internal anchoring, this master thesis has sought to answer the following thesis statement: how can IBM Denmark strategically work with CSR partnerships and how are the...

  19. Regulatory Interactions of Csr Components: the RNA Binding Protein CsrA Activates csrB Transcription in Escherichia coli

    OpenAIRE

    Gudapaty, Seshagirirao; Suzuki, Kazushi; Wang, Xin; Babitzke, Paul; Romeo, Tony

    2001-01-01

    The global regulator CsrA (carbon storage regulator) of Escherichia coli is a small RNA binding protein that represses various metabolic pathways and processes that are induced in the stationary phase of growth, while it activates certain exponential phase functions. Both repression and activation by CsrA involve posttranscriptional mechanisms, in which CsrA binding to mRNA leads to decreased or increased transcript stability, respectively. CsrA also binds to a small untranslated RNA, CsrB, f...

  20. Harmonization in CSR reporting: MNEs and global CSR standards

    NARCIS (Netherlands)

    F. Fortanier; A. Kolk; J. Pinkse

    2011-01-01

    This paper focuses on MNEs’ corporate social responsibility (CSR) reporting, which previous studies have found to exhibit strong country-of-origin effects. It examines whether MNEs’ adherence to global standards (as adopted by e.g. ILO, OECD, UN, ISO) is associated with smaller cross-country differe

  1. Analysis of Cheminova CSR practice

    DEFF Research Database (Denmark)

    Jørgensen, Michael Søgaard; Milanez, Bruno; Porto, Marcelo Firpo

    This working paper is part of a case study about the international environmental and social performance of the multinational Danish pesticide manufacturing and marketing company Cheminova. In the paper the practice of Cheminova is described and characterised based on its CSR reports from 2007...

  2. Requirements management: A CSR's perspective

    Science.gov (United States)

    Thompson, Joanie

    1991-01-01

    The following subject areas are covered: customer service overview of network service request processing; Customer Service Representative (CSR) responsibility matrix; extract from a sample Memorandum of Understanding; Network Service Request Form and its instructions sample notification of receipt; and requirements management in the NASA Science Internet.

  3. External CSR Communication in a Strategic Approach

    Directory of Open Access Journals (Sweden)

    Diana Corina GLIGOR-CIMPOIERU

    2014-12-01

    Full Text Available As part of a strategic approach, aimed at assuring mutual benefits for the social cause and the business organization, a good CSR - Corporate Social Responsibility communication is vital for the success of a CSR program. We argue that there is not a problem with the legitimacy of the CSR concept, but rather to its implementation. If a business organization implementing socially responsible initiatives is focusing only on reaping the image benefits from a simple public relations perspective, then it loses all the potential business benefits it could gain from a strategic approach focused on long term real results in a win-win perspective. The fact that the image benefit is one of the most important incentives that a business organization could obtain for engaging in CSR activities cannot be ignored, and that is the reason why we have chosen to analyse the topic of CSR communication, mainly external communication, as an important link in the process of implementing a CSR program, that plays an important part for the success of a CSR program. The approach on CSR communication should definitely be a strategic one, and long already common forms of external CSR communication like web pages or CSR annual reports new means of social media networks have an increasing importance. For the practical part of the paper, we were interested in analyzing how much of the external CSR communication in the Romanian business environment is oriented toward a traditional or a strategic approach.

  4. CSR Gravity Field Data Products

    Science.gov (United States)

    Bettadpur, Srinivas

    2014-05-01

    The joint NASA/DLR GRACE mission has successfully operated for nearly 12 years, and has provided a remarkable record of global mass flux due to a large variety of geophysical and climate processes at various spatio-temporal scales. The University of Texas Center for Space Research (CSR) hosts the mission PI, and is responsible for delivery of operational (presently denoted as Release-05 or RL05) gravity field data products. In addition, CSR generates and distributes a variety of other gravity field data products, including products generated from the use of satellite laser ranging data. This poster will provide an overview of all these data products, their relative quality, potential applications, and future plans for their development and delivery.

  5. CSR Important to Oil Companies

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ Corporations are human endeavors, and all human endeavors should benefit our society and reflect our morals. They should provide more than just investor return. The nature of oil industry demands that oil companies be socially responsible in addition to operating in an ethical and environmentally friendly manner. At a time of rising energy prices and global concern over our energy future, however, oil companies should give even greater emphasis to this part of their approach to corporate social responsibility(CSR).

  6. Electron Cooling Experiments in CSR

    CERN Document Server

    Xiaodong, Yang

    2011-01-01

    The six species heavy ion beam was accumulated with the help of electron cooling in the main ring of Cooler Storage Ring of Heavy Ion Research Facility in Lanzhou(HIRFL-CSR), the ion beam accumulation dependence on the parameters of cooler was investigated experimentally. The 400MeV/u 12C6+ and 200MeV/u 129Xe54+ was stored and cooled in the experimental ring CSRe, the cooling force was measured in different condition.

  7. Electron cooling experiments in CSR

    Institute of Scientific and Technical Information of China (English)

    PARKHOMCHUK; Vasily; REVA; Vladimir

    2011-01-01

    The six species heavy ion beam was accumulated with the help of electron cooling in the main ring of Cooler Storage Ring of Heavy Ion Research Facility in Lanzhou (HIRFL-CSR). The ion beam accumulation dependence on the parameters of cooler was investigated experimentally. The 400 MeV/u 12C6+ and 200 MeV/u 129Xe54+ were stored and cooled in the experimental ring CSRe, and the cooling force was measured in different conditions.

  8. Operationalizing CSR through Project Conception

    DEFF Research Database (Denmark)

    Kampf, Constance Elizabeth

    2013-01-01

    The purpose of this paper is to address issues raised about the content of business education—moving away from a business-centered approach to understanding management, opening up a space for reflection, and offering tools to support this change in paradigm. Strand points out these issues as “rel...... of project conception by management can be understood as the place where CSR and sustainability practices can be operationalized in the base unit of work for many corporations—the project....

  9. Conceptions of CSR in management education

    DEFF Research Database (Denmark)

    Lystbæk, Christian Tang

    policy instruments used to promote CSR have been regulation, market-based instruments and voluntary agreements, but in recent years, policies have started to focus on education. Many different actors, such as business schools, businesses and governments, interact in shaping management education...... in management education policies, programs and practices. The aim of this paper is to make a first contribution to a critical analysis of the conceptions of CSR in management education policy. Based on a qualitative deconstructive analysis of management education policies, the paper identifies three main...... conceptions of CSR in management education policy and discusses their implications; a narrow economic conception of CSR, a broader economic conception of CSR and an all-encompassing systemic conception of CSR....

  10. CRAFTING CORPORATE SOCIAL RESPONSIBILITY (CSR): A CASE STUDY OF CSR STRATEGIZING AND INSTITUTIONALIZATION

    OpenAIRE

    Krikorian, Frederic

    2009-01-01

    This dissertation aims to fill a gap in CSR research by adopting a constructivist perspective to investigate how CSR practitioners craft strategies and how this contributes to the institutionalization of CSR in general, and of the ‘business case for CSR’ in particular. It does so by relying on the strategy-as-practice approach and the notions of institutional entrepreneurship and institutional work. This dissertation is based on a single-case study of two CSR practitioners who implemented a C...

  11. CSR IN MEXICO: SHIFTING FROM PHILANTHROPY TO STRATEGIC CSR IN THE BANKING SECTOR

    OpenAIRE

    Maria Castillo

    2013-01-01

    Developing countries, such as Mexico, have traditionally associated Corporate Social Responsibility (CSR) with philanthropy and have rarely integrated CSR strategies into its core business. However, the 2008 financial crisis has increased public scrutiny of the financial sector practices, leading banks to rethink the way they approach CSR. As part of this new approach to CSR, banks in Mexico are attempting to move away from a solely philanthropic view towards a more strategic implementation t...

  12. The role of CSR and CSR Communication in Finnish natural stone industry

    OpenAIRE

    Palin, Maria

    2015-01-01

    Objective of the Study: The objective of this thesis is to examine Corporate Social Responsibility (CSR) communication in Finnish natural stone companies. Since the majority of the companies are small and medium-sized enterprises (SMEs), the focus is on CSR and CSR communication in the SME context. The study aims to answer the following research questions: (1) How do Finnish natural stone company executives perceive CSR and its role in their business? (2) To what extent do Finnish natural...

  13. Proportion cured models applied to 23 cancer sites in Norway.

    Science.gov (United States)

    Cvancarova, Milada; Aagnes, Bjarte; Fosså, Sophie D; Lambert, Paul C; Møller, Bjørn; Bray, Freddie

    2013-04-01

    Statistical cure is reached when a group of patients has the same mortality as cancer-free individuals. Cure models predict the cured proportion and the median survival of fatal cases. Cure models have seldom been applied and tested systematically across all major cancer sites. Incidence and follow-up data on 23 cancer sites recorded at the Cancer Registry of Norway 1963-2007 were obtained. Mixture cure models were fitted to obtain trends and up-to-date estimates (based on period approach) assuming cured and uncured groups exist. The model converged for cancers of the mouth and pharynx, oesophagus, stomach, colon, rectum, liver, gallbladder, pancreas, lung and trachea, ovary, kidney, bladder, CNS, non-Hodgkin lymphoma (only for males) and leukemia. The proportion of cured patients increased 1963-2002 for both sexes, with the largest changes (in percent) seen for leukemia (46.4 and 46.7) and CNS (35.9, 42.0), males given first. Median survival time for the uncured cases increased for colon and rectal cancer, and there was a three- fold increase in median survival time for patients with fatal ovarian cancers. Cancers of bladder and CNS had the highest up-to-date proportion cured (in percent), 67.4 and 64.0, respectively, pancreas and liver were amongst the lowest (5.7 and 9.9, respectively). Cure models are useful when monitoring progress in cancer care, but must be applied and interpreted with caution. The absolute estimates of the cure proportion are speculative and should not be calculated where cure is not medically anticipated. PMID:22927104

  14. CSR: FOCUS ON EMPLOYEES. ITALIAN CASES.

    Directory of Open Access Journals (Sweden)

    Patrizia Gazzola

    2014-12-01

    Full Text Available The aim of the paper is to analyze the Corporate Social Responsibilitys (CSR influence on employees considering the fact that employees are primary stakeholders who directly contribute to the success of the company. CSR relates to employees helps to motivate the employees themselves. Job quality should be a key objective of any employer because the happy employees can create happy customers, which produce good business results. Research clearly indicates, with the help of statistical data and with the case study methodology, that committing to CSR boosts the morale and commitment of workers in a positive way. Employees who are satisfied with the organization s commitment to social and environmental responsibilities demonstrate more commitment, engagement and productivity. A conceptual framework is proposed based on literature. The author predominantly uses methods of qualitative research. In the research the case study methodology, which has been developed within the social sciences, is used. The paper starts with a concise introduction of CSR. In the first part the potential impact of CSR on employees is explained, considering why CSR may represent a special opportunity to positively influence employees’ and prospective employees’ perceptions of companies. In the second part the research considers three Italian companies that have distinguished themselves for their CSR strategy for employees: Luxottica, Brunello Cucinelli and Ferrero. A growing number of studies have been done regarding the benefits of CSR. However, most are concerned with the external view of shareholders and customer perspective. CSR research on the employee level is not well developed now. In order to better understand its effect on the employees, this study explore the impact of employees' perception of CSR on subsequent work attitudes and behaviors. CSR has a significant effect and it could improve employees' attitudes and behaviors, contribute to corporations' success

  15. Implementasi CSR terhadap Kesejahteraan Hidup Masyarakat

    OpenAIRE

    Andi Mapisangka

    2009-01-01

    Corporate Social Responsibility (CSR) is the firm commitment to the environment in achieving social live welfare. This research aims to analyze the effect of CSR of PT. Batamindo Investment Cakrawala to social live welfare. The indicators of CSR are corporate social responsibility goal, corporate social issues, and corporate relation program. The indicators of welfare live are progress on health, education, and economic activity. Based on ordinary least square, this research concludes: corpor...

  16. The Business Excellence Model for CSR Implementation?

    DEFF Research Database (Denmark)

    Neergaard, Peter; Gjerdrum Pedersen, Esben Rahbek

    2012-01-01

    Most of the Fortune 500 companies address Corporate Social Responsibility (CSR) on their websites. However, CSR remains a fluffy concept difficult to implement in organization. The European Business Excellence Model has since the introduction in 1992 served as a powerful tool for integrating...... European Award winning company has used the model to integrate CSR. The company adapted the Business Excellence model to improve performance, stimulate innovation and consensus....

  17. Impact of CSR on corporate perfomance

    OpenAIRE

    Pirkl, Jakub

    2014-01-01

    The main goal of this thesis is to introduce the concept of CSR and to describe the impact of socially responsible activities on corporate performance of IBM. The thesis is divided into two parts - theoretical and practical part. The theoretical part is concerned with introducing the concept of CSR, its key principles and studies dealing with the relationship between CSR and corporate performance. The practical part is concerned with introducing IBM's approach to corporate social responsibili...

  18. Taking stock of CSR & SMEs in development

    OpenAIRE

    Jeppesen, Soeren

    2009-01-01

    The international literature on Corporate Social Responsibility (CSR) has focused on large rms, in the North, mostly applying normative, universal and positivist approaches. However, over the last 10-15 years increasing attention has been directed towards micro, small and medium-sized rms, SMEs. While the focus on CSR in SMEs mainly has been con ned to a Northern context, limited, though growing, focus has been on CSR in SMEs in a Southern or developing country context. Th...

  19. CSR Impedance for Non-Ultrarelativistic Beams

    Energy Technology Data Exchange (ETDEWEB)

    Li, Rui [Jefferson Lab., Newport News, VA (United States); Tsai, Cheng Y. [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Jefferson Lab., Newport News, VA (United States)

    2015-09-01

    For the analysis of the coherent synchrotron radiation (CSR)-induced microbunching gain in the low energy regime, such as when a high-brightness electron beam is transported through a low-energy merger in an energy-recovery linac (ERL) design, it is necessary to extend the CSR impedance expression in the ultrarelativistic limit to the non-ultrarelativistic regime. This paper presents our analysis of CSR impedance for general beam energies.

  20. CSR INTEGRATION INTO THE CORPORATE STRATEGY

    OpenAIRE

    Patrizia GAZZOLA; Colombo, Gianluca

    2014-01-01

    The aim of this research paper is to develop a model for the integration of ethics and Corporate Social Responsibility (CSR) into the company strategy as a source of competitive advantages. CSR is an organization's obligation to consider the interests of their customers, employees, shareholders, communities and to consider the social and environmental consequences of their business activities. By integrating CSR into the corporate strategy and stakeholder management, organizations can ensure ...

  1. CSR strategie v letectví

    OpenAIRE

    Foralová, Jitka

    2009-01-01

    This thesis deals with the general concept of Corporate Social Resonsibility (CSR), its principles and contributions which have been applied to the air transport market. The first chapter defines the notion of CSR, analyzes three pillars of sustainable development and discusses the opinions that fundamentally reject the CSR concept. The second and the third chapter look at the aviation industry from the sustainable development point of view. Discussion about social contributions of the air tr...

  2. External CSR Communication in a Strategic Approach

    OpenAIRE

    Diana Corina GLIGOR-CIMPOIERU; Valentin Partenie MUNTEANU

    2014-01-01

    As part of a strategic approach, aimed at assuring mutual benefits for the social cause and the business organization, a good CSR - Corporate Social Responsibility communication is vital for the success of a CSR program. We argue that there is not a problem with the legitimacy of the CSR concept, but rather to its implementation. If a business organization implementing socially responsible initiatives is focusing only on reaping the image benefits from a simple public relations perspective, ...

  3. CSR ve vybrané společnosti

    OpenAIRE

    Mejdrová, Aneta

    2012-01-01

    The objective of this dissertation is appraisal of the current status of Accenture's CSR initiatives. The theoretical part provides information that is essential for understanding CSR concept; it defines business ethics, a stakeholder theory and the triple bottom line of CSR. Furthermore, it provides a comprehensive view of the history and evolution of CSR and presents possibilities of measuring of CSR. Practical part is focused on Accenture's local and global CSR activities which are evaluat...

  4. Magnitude and Leading Sites of Cancer in A Tertiary Cancer Care Hospital of Western Maharashtra

    Directory of Open Access Journals (Sweden)

    Kapil H Agrawal, S.S. Rajderkar

    2011-01-01

    Full Text Available Context: It is observed that cancers are increasingly seen in both genders and all the age groups due to a complex interaction of various risk factors. To implement the Public health intervention measures it is essential to have the baseline data regarding frequency, distribution of cancers in the population. Aims: To study the magnitude of cancers by obtaining a baseline data regarding the frequency, distribution, leading cancer sites among the patients in a tertiary cancer care hospital of Western Maharashtra. Study settings: Shri Siddhivinayak Ganapati Cancer Hospital, Miraj Study Design: Hospital based, Cross sectional study involving retrospective information of patients from 1st March 2005 to 28th February 2006. Methods and Material: Retrospective, questionnaire study of patients from 1st March 2005 to 28th February 2006. Out of the total 2168 new patients registered, 1891 patients were detected to be malignant and included in the study. Results: 63.5 % Males and 67% Females in the age group 35-64 years had cancer. The sex ratio percent was 1.01%. Top five Cancer in males in our study were Oral Cavity, Oesophagus, Lung, Larynx and NHL. Top five Cancer in females in our study were Cervix, Breast, Ovary, Oral Cavity and Oesophagus. 27% were TRCs (Tobacco Related Cancers in males while 9.6% were TRCs in females. 34% cancers were in easily accessible parts of body. Conclusions: The Tobacco Related Cancers represent the most preventable form of cancer in our society. It was 27% in males and 9.6% in females in our study. Additionally 34% cancers were in easily accessible parts of body. It highlights the possibility of easy and early detection of cancers in the population thus decreasing the cancer burden in the community.

  5. CSR in Indonesia : a qualitative study from a managerial perspective regarding views and other important aspects of CSR in Indonesia

    OpenAIRE

    Lindgren, Fredrik; Hendeberg, Simon

    2009-01-01

    This paper will from a managerial perspective investigate the function of CSR (Corporate Social Responsibility) as a strategic tool for companies operating in Indonesia.Another aspect this paper will discuss is different views on CSR and what positive aswell as negative aspects CSR brings. The country was first in the world to state a lawregarding CSR performance in 2007, which makes CSR mandatory for all companiesusing natural resources in some way. This issue complicates CSR matters in Indo...

  6. China’s CSR Has Both Common and Unique Dimensions as Compared with Western CSR

    Institute of Scientific and Technical Information of China (English)

    徐尚昆; 杨汝岱

    2008-01-01

    We conducted an inductive analysis of corporate social responsibility (CSR) in China based on an open-ended survey of 630 CEOs and business owners in 12 provinces and municipalities across China. In the survey, we collected 2811 CSR sample scenarios. After examining the quantitative data thus acquired, we identified 9 dimensions of CSR, including two dimensions never mentioned in western literature and another 2 dimensions generally recognized in western countries but not yet taking shape in China. A comparative study of CSR between China and western countries also unveiled some unique dimensions of CSR in China.In conclusion, CSR has been manifested in China in a form different from that in western countries, and China’s CSR is closely related to the social and cultural background of China.

  7. Political CSR in an SME Perspective

    OpenAIRE

    Jeppesen, Søren; Morsing, Mette

    2013-01-01

    We engage a discussion of political CSR in SMEs in an African context. Based on critical observations on Western MNC action in emerging economies, political economists have argued that business profit far more than society from CSR. In this paper we argue that the imperative for growth in developing economies provide an option to con...

  8. Integral Measurement of Dipole Prototype of CSR

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The dipole prototype is C type used as bending magnet of the injection beam line in CSR, and acts as a model of the dipoles in the CSR main ring simultaneously. The designed relative uniformity of good field is 0.001 in 100 mm width. The results of the local distribution and transfunction at transverse profile measured

  9. CSR INTEGRATION INTO THE CORPORATE STRATEGY

    Directory of Open Access Journals (Sweden)

    Patrizia GAZZOLA

    2014-12-01

    Full Text Available The aim of this research paper is to develop a model for the integration of ethics and Corporate Social Responsibility (CSR into the company strategy as a source of competitive advantages. CSR is an organization's obligation to consider the interests of their customers, employees, shareholders, communities and to consider the social and environmental consequences of their business activities. By integrating CSR into the corporate strategy and stakeholder management, organizations can ensure that the increasing of shareholder value doesn’t overshadow the need to behave ethically to their stakeholders. The research is based on the theoretical framework that supports a thesis of beneficial impact of the development and implementation of CSR plan: by planning out CSR as part of a corporate strategy, companies can achieve the ultimate goal of creating both social value and corporate value.

  10. The Business Excellence Model for CSR Implementation?

    Directory of Open Access Journals (Sweden)

    Neergaard Peter

    2014-11-01

    Full Text Available Most of the Fortune 500 companies address Corporate Social Responsibility (CSR on their websites. However, CSR remains a fluffy concept difficult to implement in organization. The European Business Excellence Model has since the introduction in 1992 served as a powerful tool for integrating quality in organizations. CSR was first introduced in the model in 2002. From 2004 the European Foundation for Quality Management (EFQM has been eager to promote the model as an effective tool for implementing CSR.. The article discusses the potentials of the model for this end and illustrates how a 2006 European Award winning company has used the model to integrate CSR. The company adapted the Business Excellence model to improve performance, stimulate innovation and consensus.

  11. Stakeholder involvement in CSR strategy-making?

    DEFF Research Database (Denmark)

    Trapp, Leila

    2014-01-01

    A given characteristic of successful corporate social responsibility (CSR) programs is that they reflect stakeholder expectations and preferences for corporate behavior. This study examines the process by which this alignment is sought by CSR managers in the CSR strategy-making process. Through...... reliance on stakeholder management theories, and with a particular focus on how and why managers communicate with stakeholders, the extent to which the company-stakeholder alignment process in CSR strategy-making reflects modern, enlightened approaches to stakeholder relations is assessed. This assessment...... is based on an analysis of structured, in-depth interviews with CSR managers from sixteen industry-leading, Danish companies. The managers’ descriptions of their interactions with stakeholders reveal that their practices fall short of the normative, theoretical ideals since their focus is primarily on just...

  12. Impact of IACS Harmonized CSR on Tankers

    Institute of Scientific and Technical Information of China (English)

    郑文青; 吴嘉蒙; 刘寅华; 顾俊

    2014-01-01

    The external draft of Harmonized Common Structural Rules (CSR-H) for Bulk Carriers and Oil Tankers has been released for external review. Based on a consistent methodology at the adoption of the current CSR, CSR-H aims to be in compliance with the IMO GBS where GBS functional requirements fall within the scope, and the safety level is equivalent to or higher than the current CSR criteria. In this paper, by consequence assessment on a 320k VLCC, a 163k Suezmax tanker, a 115k Aframax tanker, a 76k Panamax tanker and a 48k MR tanker, the results of the comparison on the structural scantlings to CSR, the evaluation on the increasing of steel weight and some critical technique issues are discussed.

  13. Reflexive regulation of CSR to promote sustainability

    DEFF Research Database (Denmark)

    Buhmann, Karin

    2011-01-01

    and the EU CSR Alliance. Focusing on human rights based in international law, it analyses the patterns of negotiation in the MSF and the background for the launch of the CSR Alliance. It shows that analysing public-private regulation of CSR from the perspective of reflexive law theory assists us...... in understanding the mechanisms by which public authorities seek to influence firm’s behaviour through CSR in order to promote public policy objectives. The analysis indicates that to be effective, reflexive regulatory approaches to public-private regulation should pay careful attention to procedural design...... in order to balance power disparities among participants. Finally, the analysis suggests that a juridification of CSR is taking place. This development is welcome because legal theory and scholarship’s insight into institutionalisation of norms of conduct has much to offer to society’s interests...

  14. Reflexive regulation of CSR to promote sustainablility

    DEFF Research Database (Denmark)

    Buhmann, Karin

    and the EU CSR Alliance. Focusing on human rights based in international law, it analyses the patterns of negotiation in the MSF and the background for the launch of the CSR Alliance. It shows that analysing public-private regulation of CSR from the perspective of reflexive law theory assists us...... in understanding the mechanisms by which public authorities seek to influence firm’s behaviour through CSR in order to promote public policy objectives. The analysis indicates that to be effective, reflexive regulatory approaches to public-private regulation should pay careful attention to procedural design...... in order to balance power disparities among participants. Finally, the analysis suggests that a juridification of CSR is taking place. This development is welcome because legal theory and scholarship’s insight into institutionalisation of norms of conduct has much to offer to society’s interests...

  15. The Cultural and Rhetorical Parameters of CSR

    DEFF Research Database (Denmark)

    Kampf, Constance

    -construction of CSR discourse through interaction and power relations between "civil society actors" and "the more powerful corporate voices."   In incorporating the cultural systems approach to CSR (Kampf 2007) with Burchell and Cook's argument of a two-way process, government can also be included as part...... of these situated interactions, rhetorical tools such as Brockreide's rhetorical dimension of attitude (1996) and Burke's notions of terministic screens and entitlement (1966) offer a means of demonstrating how language used to describe CSR is co-constructed in a cultural system in which businesses are situated......, but not focal.   De-centering business in the understanding of CSR on the Internet offers potential for analyzing CSR discourse as a dynamic system of ideas visible on the Internet, which allows multiple voices and inhibits traditional gatekeepers. Comparing both the cultural systems of the U.S. and Denmark...

  16. Molecular geometry of CsrA (RsmA) binding to RNA and its implications for regulated expression

    OpenAIRE

    Mercante, Jeffrey; Edwards, Adrianne N; Ashok K Dubey; Babitzke, Paul; Romeo, Tony

    2009-01-01

    The global regulatory protein CsrA binds to the 5′-untranslated leader of target transcripts and alters their translation and/or stability. CsrA is a symmetrical homodimer containing two identical RNA-binding surfaces. Gel shift assays with model RNA substrates now show that CsrA can bind simultaneously at two target sites within a transcript (bridging or dual site binding). An intersite distance of ∼18 nucleotides (nt) was optimal, although bridging occurred with an intersite distance of 10 ...

  17. Radon measurements of some cities with CSR detectors

    International Nuclear Information System (INIS)

    The indoor and outdoor radon measurements in Haerbin and Yanan have been made with CSR (China Shanghai Resin) detectors. At main measuring sites the balloon method has been used to measure the latent energy of daughters and the equilibrium factor. The results by the two methods have been compared and analysed. The measurements with CSR detectors indicate that the indoor radon concentration ranges from 16 to 144 Bq/m3 with an average of 73 Bq/m3 in Haerbin, and from 13 to 78 Bq/m3 with an average of 35 Bq/m3 in Yanan. The results are compared with those with the balloon method, showing that the two methods are consistent within an error of 40%

  18. Breaking through the self-fulfilling prophecy of CSR

    NARCIS (Netherlands)

    Nijhof, A.H.J.; Zwart, van der A.; Jonker, J.

    2009-01-01

    Since the last decades of the twentieth century the debate on the concept of corporate social responsibility (CSR) intensified significantly. This debate concentrates on the meaning, impact and possible gains from CSR. Alongside the growing number of CSR advocates there are also a number of CSR crit

  19. Industrial Clusters and CSR in Developing Countries

    DEFF Research Database (Denmark)

    Fayyaz, Anjum; Lund-Thomsen, Peter; Lindgreen, Adam

    2015-01-01

    This article contributes to literature on corporate social responsibility (CSR) exhibited by industrial clusters in developing countries. The authors conceptualize and empirically investigate the role of donor-funded CSR initiatives aimed at promoting collective action by cluster-based small- and......, tensions within SME networks, and negative perceptions of CSR by the cluster-based SMEs themselves. The findings and implications of this analysis can inform both research and policy making in this area......This article contributes to literature on corporate social responsibility (CSR) exhibited by industrial clusters in developing countries. The authors conceptualize and empirically investigate the role of donor-funded CSR initiatives aimed at promoting collective action by cluster-based small......- and medium-sized enterprises (SMEs). A case study of the Sialkot football-manufacturing cluster in Pakistan indicates that donor-funded support of CSR initiatives in industrial clusters in developing countries may be short-lived, due to the political economy of aid, the national context of CSR implementation...

  20. Circuitry Linking the Csr and Stringent Response Global Regulatory Systems

    OpenAIRE

    Edwards, Adrianne N; Patterson-Fortin, Laura M.; Christopher A Vakulskas; Mercante, Jeffrey W.; Potrykus, Katarzyna; Vinella, Daniel; Camacho, Martha I.; Fields, Joshua A.; Thompson, Stuart A.; Georgellis, Dimitris; Cashel, Michael; Babitzke, Paul; Romeo, Tony

    2011-01-01

    CsrA protein regulates important cellular processes by binding to target mRNAs and altering their translation and/or stability. In Escherichia coli, CsrA binds to sRNAs, CsrB and CsrC, which sequester CsrA and antagonize its activity. Here, mRNAs for relA, spoT and dksA of the stringent response system were found among 721 different transcripts that copurified with CsrA. Many of the transcripts that copurified with CsrA were previously determined to respond to ppGpp and/or DksA. We examined m...

  1. Global and regional estimates of cancer mortality and incidence by site: I. Application of regional cancer survival model to estimate cancer mortality distribution by site

    Directory of Open Access Journals (Sweden)

    Lopez Alan D

    2002-12-01

    Full Text Available Abstract Background The Global Burden of Disease 2000 (GBD 2000 study starts from an analysis of the overall mortality envelope in order to ensure that the cause-specific estimates add to the total all cause mortality by age and sex. For regions where information on the distribution of cancer deaths is not available, a site-specific survival model was developed to estimate the distribution of cancer deaths by site. Methods An age-period-cohort model of cancer survival was developed based on data from the Surveillance, Epidemiology, and End Results (SEER. The model was further adjusted for the level of economic development in each region. Combined with the available incidence data, cancer death distributions were estimated and the model estimates were validated against vital registration data from regions other than the United States. Results Comparison with cancer mortality distribution from vital registration confirmed the validity of this approach. The model also yielded the cancer mortality distribution which is consistent with the estimates based on regional cancer registries. There was a significant variation in relative interval survival across regions, in particular for cancers of bladder, breast, melanoma of the skin, prostate and haematological malignancies. Moderate variations were observed among cancers of colon, rectum, and uterus. Cancers with very poor prognosis such as liver, lung, and pancreas cancers showed very small variations across the regions. Conclusions The survival model presented here offers a new approach to the calculation of the distribution of deaths for areas where mortality data are either scarce or unavailable.

  2. Turning CSR on it's head

    DEFF Research Database (Denmark)

    Kampf, Constance Elizabeth

    , rather than impermeable boundaries. Thus, social and mobile media can be approached as a force that works at further eroding boundaries between the firm and technology empowered individuals equipped with their personal agendas and social media capital. As an example of social media turning tradition...... their ecological footprint. Then CarrotMob members use social media to recruit as many customers as possible to shop at that time, thus increasing both profits and available resources for the business to engage in sustainability. As sustainability and CSR are enacted differently in the US and EU (Matten and Moon....... However, from a technology perspective, Howe (2009) argues that the boundaries of the firm are becoming porous, and through social media people are contributing some of their best energy for free. These technology empowered stakeholders can be resources for strategy when the firm is seen as having porous...

  3. THE IMPORTANCE OF CSR IMPLEMENTATION

    Directory of Open Access Journals (Sweden)

    Anna Križanová

    2016-09-01

    Full Text Available The last three decades of the twentieth century and the beginning of the twenty-first century were marked by the expansion of managerial ethics and social responsibility of business. Business ceased to be perceived in terms of profit being the sole interest of management, and ethical aspects were stressed more so in connection with the company’s management. Specific managerial ethical initiatives and activities leading from outside and inside the organization constitutes the concept of Corporate Social Responsibility (CSR, which comprises many factors. The aim of this paper is to summarize the positive impact of corporate social responsibility for business activities using secondary data from global surveys and then confirm the importance and benefits of corporate social responsibility for enterprises in the Slovak Republic using primary data.

  4. Mitarbeiterrekrutierung und -bindung durch CSR: Erkenntnisse aus sechs Fallstudien

    OpenAIRE

    Pelzeter, Andrea; Bustamante, Silke; Deckmann, Andreas; Ehlscheidt, Rudi; Freudenberger, Franziska

    2015-01-01

    Im Rahmen des Forschungsprojektes MitCSR wurden sechs Fallstudien ausgearbeitet, die der Frage nachgingen, welche Wirkung Corporate Social Responsibility auf die Rekrutierung und Bindung von Mitarbeitern hat. Für die Erhebung der Wirkung wurden die Einflussfaktoren CSR-Performanz und CSR-Kommunikation von der abhängigen Variable CSR-Wahrnehmung unterschieden (CSR-Trias). In fragebogengestützten Interviews wurde die Perspektive der Unternehmensleitung sowie der bestehenden Mitarbeiter erhoben....

  5. From philanthropy to strategy? An assessment of Indian CSR.

    OpenAIRE

    Træsborg, Emilie Levin

    2014-01-01

    This thesis examines how the Indian CSR-approach conforms to the global strategic CSR-trend. To conduct the study, main characteristics of strategic CSR has been identified through institutional theory as corporations, and their responsible behavior, is a dominant institution in todays globalized society. Furthermore, the traditional characteristics of Indian corporate philanthropy have been identified in order to comprehend if the Indian CSR-approach conforms to global strategic CSR in a dis...

  6. The political economy of corporate social responsibility (CSR)

    OpenAIRE

    2012-01-01

    This dissertation aims to contribute to a more contextually informed analysis of CSR by studying how political-economic institutions influence CSR practices. Approaching CSR as a political phenomenon, the dissertation studies quantitatively whether political-economic institutions can explain variation in CSR practices across 20 advanced capitalist countries, as cross-national variation provides a key to understand the institutional foundations of CSR. However, the dissertation also seeks to p...

  7. Corporate social responsibility communication in social networking sites: unfinalisable and dialogical processes of legitimation

    OpenAIRE

    Glozer, Sarah Alice

    2015-01-01

    Building upon constitutive models of corporate social responsibility (CSR) communication, which appreciate the role of both organisations and stakeholders in constructing CSR, this thesis suggests that understanding of CSR is on-going and emergent through unfinalisable legitimation processes in social networking sites (SNSs). Constructed upon management research that has examined discursive legitimation processes, this thesis shifts away from CSR communications research into websites, CSR rep...

  8. How can CSR affect company performance? : A qualitative study of CSR and its effects

    OpenAIRE

    Classon, Johan; Dahlström, Johan

    2006-01-01

    In today’s society, there is a growing interest in, and demand for Corporate Social Responsibility (CSR). Reasons for this can be multinational corporations’ increasing influence on world economy as well as scandals revealing horrible working conditions in different industries. In spite of the fact that the demand for CSR is growing, there has always been critics. The most influential critic is Noble Prize winner Milton Friedman, who claims CSR to be a waste of stockholders’ money. However, s...

  9. CSR: friend or foe? Framing NGO Strategy through CSR in the Pursuit of Sustainable Funding

    OpenAIRE

    Singleton, Sarah

    2006-01-01

    Through the application of frame analysis, corporate social responsibility (CSR) can currently be envisaged in relation to two extreme frames in analysing CSR as an interface for business-NGO collaborations: an altruistic frame (involving short-term, philanthropic business gestures towards NGOs) and a strategic frame (involving long-term, strategic relations between business and NGOs). It is proposed that businesses align with a strategic CSR frame (the business case) and as a consequence of ...

  10. CSR Beyond Borders : A Qualitative Study of International Companies' CSR Adjustment in Dubai

    OpenAIRE

    2013-01-01

    The concept of Corporate Social Responsibility (CSR) receives increasing global attention in academia, the business world and international civil society. This master thesis aims to examine the global spread of CSR across territorial and cultural borders. The globalization literature describes diffusion of ideas as a reason why and how this spread takes place, this thesis uses this theoretical framework to examine how the Western concept of CSR reacts with local environments. The thesis ...

  11. How to motivate managers for CSR?: commitment to CSR by transformational leadership in meetings

    OpenAIRE

    Wabitsch, Vanessa Vivian

    2014-01-01

    Dissertation submitted as partial requirement for the conferral of Master in Marketing / JEL Justification System: M10 – General; M14 – Corporate Culture; Social Responsibility. Purpose: The aim of this research is to examine how it is possible to continuously motivate managers from different departments for Corporate Social Responsibility (CSR). The goal is to investigate if and how CSR leaders can realize commitment to CSR by conducting meetings in transformational leaders...

  12. Regulatory Circuitry of the CsrA/CsrB and BarA/UvrY Systems of Escherichia coli

    OpenAIRE

    Suzuki, Kazushi; Wang, Xin; Weilbacher, Thomas; Pernestig, Anna-Karin; Melefors, Öjar; Georgellis, Dimitris; Babitzke, Paul; Romeo, Tony

    2002-01-01

    The global regulator CsrA (carbon storage regulator) is an RNA binding protein that coordinates central carbon metabolism, activates flagellum biosynthesis and motility, and represses biofilm formation in Escherichia coli. CsrA activity is antagonized by the untranslated RNA CsrB, to which it binds and forms a globular ribonucleoprotein complex. CsrA indirectly activates csrB transcription, in an apparent autoregulatory mechanism. In the present study, we elucidate the intermediate regulatory...

  13. Study of matching between HIRFL and CSR

    International Nuclear Information System (INIS)

    'HIRFL-CSR Cooler Storage Ring' makes use of existing HIRFL as its pre-accelerator. In order to take the full capability of HIRFL, the authors have studied in detailed the matching modes between HIRFL and CSR. It is proposed to use two matching modes; direct matching between SFC (HIRFL injector cyclotron) and CSRm (CSR main ring); three-cascade matching of SFC, SSC (HIRFL main cyclotron) and CSRm. With these combinations, better beam transmission efficiency, better beam utilization efficiency of HIRFL-CSR accelerator complex and better operation efficiency of HIRFL can be obtained. In the first case, SSC can be used simultaneously in other purposes, either to accelerate medium energy heavy ions or to accelerate protons combined with another small cyclotron

  14. CSR Institutionalized Myths in Developing Countries

    DEFF Research Database (Denmark)

    Jamali, Dima; Lund-Thomsen, Peter; Khara, Navjote

    2015-01-01

    place, and how developing country firms can gain credit and traction by focusing on high visibility CSR issues, although the plight of workers remains fundamentally unchanged. The authors revisit these findings in the discussion and concluding sections, highlighting the main research and policy......This article examines joint action initiatives among small- and medium-sized enterprises (SMEs) in the manufacturing industries in developing countries in the context of the ascendancy of corporate social responsibility (CSR) and the proliferation of a variety of international accountability tools...... and standards. Through empirical fieldwork in the football manufacturing industry of Jalandhar in North India, the article documents how local cluster-based SMEs stay coupled with the global CSR agenda through joint CSR initiatives focusing on child labor. Probing further, however, also reveals patterns...

  15. The C.S.R. implementation

    Directory of Open Access Journals (Sweden)

    Mihaela Bucur

    2014-12-01

    Full Text Available The enterprises which started to integrate the principles of sustainable development in their activity, in their business processes and in their philosophy of business unfolding, require that Corporate Social Responsibility (CSR actions held by the companies involved a significant component of sustainable development. In practice, it would be beneficial if every direct action of the enterprise achieved long-lasting objectives and obtained sustainable results. The original contribution of this work is therefore essential for practitioners because it identifies a series of steps to be followed for the implementation and evaluation of a company's CSR activities. The present research addresses the need for implementing the concept of CSR in up companies. Our approach is drawn from several theoretical models, simplified for a beginner integrating CSR programs. Thus, in order to know what to start with, we have identified a number of simple steps and a methodology presented in this article.

  16. The Economic Virtues of SRI and CSR

    NARCIS (Netherlands)

    J. Derwall (Jeroen)

    2007-01-01

    textabstractFinancial markets and company managers are increasingly acknowledging the concepts of socially responsible investing (SRI) and corporate social responsibility (CSR), but not without reservations. These hesitations are largely attributable to ongoing debates about a potential conflict bet

  17. CSR REPORTING IN BANKS - THE ROMANIAN EVIDENCE

    Directory of Open Access Journals (Sweden)

    Georgiana-Loredana FRECEA

    2016-06-01

    Full Text Available The dynamics of the financial markets and the significant interrelationships with broader concepts as globalization or sustainable development, have led in recent years to the development of a multidimensional approach of CSR. The credibility of the financial system is based on the financial institutions image given by representative stakeholders. They filter in an objective way the ethical responsibilities of the banks and the legal ones and give them the legitimacy to operate on the market. In order to obtain a realistic framework of CSR in Romanian banks, the article will focus on the transparency of CSR information. The confidence crisis manifested in the banking institutions can best be overcome through an authentic reporting system, which is able to fulfill a set of requirements, from credibility to completeness. This paper highlights the main characteristics of the CSR reports provided by the Romanian banking institutions, based on the stakeholder theory and using international reporting frameworks as Global Reporting Initiative.

  18. Accuracy of Self-Reported Breast Cancer Information among Women from the Ontario Site of the Breast Cancer Family Registry

    OpenAIRE

    Andriana Barisic; Gord Glendon; Nayana Weerasooriya; Andrulis, Irene L.; Knight, Julia A.

    2012-01-01

    Obtaining complete medical record information can be challenging and expensive in breast cancer studies. The current literature is limited with respect to the accuracy of self-report and factors that may influence this. We assessed the agreement between self-reported and medical record breast cancer information among women from the Ontario site of the Breast Cancer Family Registry. Women aged 20–69 years diagnosed with incident breast cancer 1996–1998 were identified from the Ontario Cancer R...

  19. Seal Structure of Vacuum System for CSR

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    To reach the design parameter of CSR, vacuum system (≤3.5x10~(-9) Pa), besides the high requirement for quality of the material and vacuum sanitation of the vacuum cells, the seal function is the most important. All cells of vacuum system for CSR are limited by the situations and rooms of gap of magnets, radio frequency system, diagnostic devices and others, and must meet the assemble and disassemble requirements of every devices.

  20. Establishing HIRFL-CSR Global Control Network

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    HIRFL-CSR global control network is used to define the correct location and orientation of accclcrator subsystems(i.e.CSRm,CSRe and Injection line)to each other.Each subsystem has its own control network,named the local control network.According to the local control network,thc components of each subsystem can be mounted to an ideal position.The original point of HIRFL-CSR global control network is on the mechanical

  1. Corporate Social Responsibility (CSR) - a Theoretical Approach

    OpenAIRE

    Bradu Cosmina Paula

    2011-01-01

    In the last years the expectations towards CSR are increasing and with this also the demand that businesses behave in a socially responsibly manner. But we should not forget that Corporate Social Responsibility (CSR) is a contested and also evolving concept, fact that is evidenced also by the different points of view concerning the definition and also by the lack of consensus about why it might be a worthy marketing objective. This article aims to ilustrate the main concepts and framworks reg...

  2. Credibility in CSR communication: concepts, methods, analyses

    OpenAIRE

    Lock, Irina; Seele, Peter

    2015-01-01

    In globalized markets, norms for legitimate behavior are scattered and businesses must satisfy often conflicting demands of various stakeholders simultaneously. This is why communicating their Corporate Social Responsibilities (CSR) in a legitimate way is challenging. The present is also a high time for a debate of CSR issues and an era of public scrutiny and mistrust, catalyzed by real-time communication technologies and a 24/7 news cycle. Instances of non-credible communication, the misus...

  3. SMEs and CSR in Developing Countries

    DEFF Research Database (Denmark)

    Jamali, Dima; Lund-Thomsen, Peter; Jeppesen, Søren

    2015-01-01

    This article is the guest editors’ introduction to the special issue in Business & Society on “SMEs and CSR in Developing Countries.” The special issue includes four original research articles by Hamann, Smith, Tashman, and Marshall; Allet; Egels-Zandén; and Puppim de Oliveira and Jabbour...... on various aspects of the relationship of small and medium enterprises (SMEs) to corporate social responsibility (CSR) in developing countries....

  4. The Quest for CSR in Closedowns

    OpenAIRE

    Rydell, Alexis; Wigblad, Rune

    2012-01-01

    This paper focuses on analysis of and suggestions for Corporate Social Responsibility (CSR) orienta- tion during the closedown process.The article addresses CSR considerations that adjust business strategies, which in turn change the Human Resource Management (HRM) focus. Our study fo- cuses on four best practice cases in Sweden, which are compared with three reported cases in the literature.All four best practice cases had a long notice period and socially responsible coordination of managem...

  5. CSR IN SMEs– SOME TERMINOLOGICAL DISTINCTIONS

    OpenAIRE

    Radu Florin OGARCA

    2013-01-01

    Corporate social responsibility (CSR) was traditionally considered a prerogative of large companies. In recent years, in practice and in the literature, specific activities of CSR have also been implemented in SMEs. Unfortunately (both in practical and theoretical dimensions), things are far from being clarified. More precisely, it seems that there is a gap between theory and practice, a transplantation of theory in practice not accurate enough. In the present paper, we intend to do some conc...

  6. CSR and aging workforces: An explorative study on CSR-implementation in SMEs

    NARCIS (Netherlands)

    Gellert , J. F.; De Graaf, J. F.

    2012-01-01

    Although critical differences exist between large companies and small- and medium-sized enterprises (SMEs), limited empirical research has been done on human resource (HR)-related corporate social responsibility (CSR). In this paper we study aging workforce management (AWM) as a component of CSR. Ou

  7. The Perspective of Social Business for CSR Strategy

    OpenAIRE

    Yokoyama, Keiko

    2009-01-01

    The growing practice of corporate social responsibility (CSR) has led to increasing research attention in the literature to the role of CSR strategy. CSR strategy is a concept for maximizing profits or benefits for both society and the company. Studies of CSR strategy during the 1990’s and the early 2000’s were mainly limited to examining the concept of CSR, and merely discussed the needs and importance of the strategic development of CSR. Recently, strategy researchers have proposed more spe...

  8. Internkommunikation av CSR : - En fallstudie av hur CSR internt förmedlas inom Clas Ohlson

    OpenAIRE

    Imeri, Dodona; Varatharajah, Kajany

    2012-01-01

    Den ökade transparensen i samhället har bidragit till att allt fler företag aktivt arbetar medCorporate Social Responsibility, CSR. Tyvärr är det många verksamheter idag som inte får tillräckligt mycket uppskattning för deras CSR-policy. Detta är för att den externa kommunikationen gentemot konsumenter inte är optimal. När konsumenter inte har kännedom om företagets CSR försvinner mycket av den konkurrenskraft som CSR bidrar med. Samtidigt kan en överdriven marknadsföring av företagets CSR-po...

  9. The cryogenic storage ring CSR

    Science.gov (United States)

    von Hahn, R.; Becker, A.; Berg, F.; Blaum, K.; Breitenfeldt, C.; Fadil, H.; Fellenberger, F.; Froese, M.; George, S.; Göck, J.; Grieser, M.; Grussie, F.; Guerin, E. A.; Heber, O.; Herwig, P.; Karthein, J.; Krantz, C.; Kreckel, H.; Lange, M.; Laux, F.; Lohmann, S.; Menk, S.; Meyer, C.; Mishra, P. M.; Novotný, O.; O'Connor, A. P.; Orlov, D. A.; Rappaport, M. L.; Repnow, R.; Saurabh, S.; Schippers, S.; Schröter, C. D.; Schwalm, D.; Schweikhard, L.; Sieber, T.; Shornikov, A.; Spruck, K.; Sunil Kumar, S.; Ullrich, J.; Urbain, X.; Vogel, S.; Wilhelm, P.; Wolf, A.; Zajfman, D.

    2016-06-01

    An electrostatic cryogenic storage ring, CSR, for beams of anions and cations with up to 300 keV kinetic energy per unit charge has been designed, constructed, and put into operation. With a circumference of 35 m, the ion-beam vacuum chambers and all beam optics are in a cryostat and cooled by a closed-cycle liquid helium system. At temperatures as low as (5.5 ± 1) K inside the ring, storage time constants of several minutes up to almost an hour were observed for atomic and molecular, anion and cation beams at an energy of 60 keV. The ion-beam intensity, energy-dependent closed-orbit shifts (dispersion), and the focusing properties of the machine were studied by a system of capacitive pickups. The Schottky-noise spectrum of the stored ions revealed a broadening of the momentum distribution on a time scale of 1000 s. Photodetachment of stored anions was used in the beam lifetime measurements. The detachment rate by anion collisions with residual-gas molecules was found to be extremely low. A residual-gas density below 140 cm-3 is derived, equivalent to a room-temperature pressure below 10-14 mbar. Fast atomic, molecular, and cluster ion beams stored for long periods of time in a cryogenic environment will allow experiments on collision- and radiation-induced fragmentation processes of ions in known internal quantum states with merged and crossed photon and particle beams.

  10. The Cryogenic Storage Ring CSR

    CERN Document Server

    von Hahn, Robert; Berg, Felix; Blaum, Klaus; Breitenfeldt, Christian; Fadil, Hisham; Fellenberger, Florian; Froese, Michael; George, Sebastian; Göck, Jürgen; Grieser, Manfred; Grussie, Florian; Guerin, Elisabeth A; Heber, Oded; Herwig, Philipp; Karthein, Jonas; Krantz, Claude; Kreckel, Holger; Lange, Michael; Laux, Felix; Lohmann, Svenja; Menk, Sebastian; Meyer, Christian; Mishra, Preeti M; Novotný, Oldřich; Connor, Aodh P O; Orlov, Dmitry A; Rappaport, Michael L; Repnow, Roland; Saurabh, Sunny; Schippers, Stefan; Schröter, Claus Dieter; Schwalm, Dirk; Schweikhard, Lutz; Sieber, Thomas; Shornikov, Andrey; Spruck, Kaija; Kumar, Sudhakaran Sunil; Ullrich, Joachim; Urbain, Xavier; Vogel, Stephen; Wilhelm, Patrick; Wolf, Andreas; Zajfman, Daniel

    2016-01-01

    An electrostatic cryogenic storage ring, CSR, for beams of anions and cations with up to 300 keV kinetic energy per unit charge has been designed, constructed and put into operation. With a circumference of 35 m, the ion-beam vacuum chambers and all beam optics are in a cryostat and cooled by a closed-cycle liquid helium system. At temperatures as low as (5.5 $\\pm$ 1) K inside the ring, storage time constants of several minutes up to almost an hour were observed for atomic and molecular, anion and cation beams at an energy of 60 keV. The ion-beam intensity, energy-dependent closed-orbit shifts (dispersion) and the focusing properties of the machine were studied by a system of capacitive pickups. The Schottky-noise spectrum of the stored ions revealed a broadening of the momentum distribution on a time scale of 1000 s. Photodetachment of stored anions was used in the beam lifetime measurements. The detachment rate by anion collisions with residual-gas molecules was found to be extremely low. A residual-gas den...

  11. The cryogenic storage ring CSR.

    Science.gov (United States)

    von Hahn, R; Becker, A; Berg, F; Blaum, K; Breitenfeldt, C; Fadil, H; Fellenberger, F; Froese, M; George, S; Göck, J; Grieser, M; Grussie, F; Guerin, E A; Heber, O; Herwig, P; Karthein, J; Krantz, C; Kreckel, H; Lange, M; Laux, F; Lohmann, S; Menk, S; Meyer, C; Mishra, P M; Novotný, O; O'Connor, A P; Orlov, D A; Rappaport, M L; Repnow, R; Saurabh, S; Schippers, S; Schröter, C D; Schwalm, D; Schweikhard, L; Sieber, T; Shornikov, A; Spruck, K; Sunil Kumar, S; Ullrich, J; Urbain, X; Vogel, S; Wilhelm, P; Wolf, A; Zajfman, D

    2016-06-01

    An electrostatic cryogenic storage ring, CSR, for beams of anions and cations with up to 300 keV kinetic energy per unit charge has been designed, constructed, and put into operation. With a circumference of 35 m, the ion-beam vacuum chambers and all beam optics are in a cryostat and cooled by a closed-cycle liquid helium system. At temperatures as low as (5.5 ± 1) K inside the ring, storage time constants of several minutes up to almost an hour were observed for atomic and molecular, anion and cation beams at an energy of 60 keV. The ion-beam intensity, energy-dependent closed-orbit shifts (dispersion), and the focusing properties of the machine were studied by a system of capacitive pickups. The Schottky-noise spectrum of the stored ions revealed a broadening of the momentum distribution on a time scale of 1000 s. Photodetachment of stored anions was used in the beam lifetime measurements. The detachment rate by anion collisions with residual-gas molecules was found to be extremely low. A residual-gas density below 140 cm(-3) is derived, equivalent to a room-temperature pressure below 10(-14) mbar. Fast atomic, molecular, and cluster ion beams stored for long periods of time in a cryogenic environment will allow experiments on collision- and radiation-induced fragmentation processes of ions in known internal quantum states with merged and crossed photon and particle beams. PMID:27370434

  12. CsrA activates flhDC expression by protecting flhDC mRNA from RNase E-mediated cleavage.

    Science.gov (United States)

    Yakhnin, Alexander V; Baker, Carol S; Vakulskas, Christopher A; Yakhnin, Helen; Berezin, Igor; Romeo, Tony; Babitzke, Paul

    2013-02-01

    Csr is a conserved global regulatory system that controls expression of several hundred Escherichia coli genes. CsrA protein represses translation of numerous genes by binding to mRNA and inhibiting ribosome access. CsrA also activates gene expression, although an activation mechanism has not been reported. CsrA activates flhDC expression, encoding the master regulator of flagellum biosynthesis and chemotaxis, by stabilizing the mRNA. Computer modelling, gel mobility shift and footprint analyses identified two CsrA binding sites extending from positions 1-12 (BS1) and 44-55 (BS2) of the 198 nt flhDC leader transcript. flhD'-'lacZ expression was reduced by mutations in csrA and/or the CsrA binding sites. The position of BS1 suggested that bound CsrA might inhibit 5' end-dependent RNase E cleavage of flhDC mRNA. Consistent with this hypothesis, CsrA protected flhDC leader RNA from RNase E cleavage in vitro and protection depended on BS1 and BS2. Primer extension studies identified flhDC decay intermediates in vivo that correspond to in vitro RNase E cleavage sites. Deletion of these RNase E cleavage sites resulted in increased flhD'-'lacZ expression. Data from mRNA decay studies and quantitative primer extension assays support a model in which bound CsrA activates flhDC expression by inhibiting the 5' end-dependent RNase E cleavage pathway. PMID:23305111

  13. Detangling Value: A study into the benefits of using in-house CSR expertise compared with the benefits of using CSR consultancy expertise

    OpenAIRE

    MacCarthy, Jennifer

    2007-01-01

    Abstract The topic of Corporate Social Responsibility (CSR) is an area with an increasing breadth of literature. However, literature regarding how CSR expertise is sourced for developing CSR projects and programmes within companies is distinctly weak. This study takes, arguably, the two most predominant forms of CSR expertise, in-house CSR expertise and CSR consultancies, and investigates what value these different types of expertise offer in sourcing for CSR activities. Bey...

  14. The CsrR/CsrS two-component system of group A Streptococcus responds to environmental Mg2+

    OpenAIRE

    Gryllos, Ioannis; Levin, James C.; Wessels, Michael R.

    2003-01-01

    Group A streptococci control expression of key virulence determinants via the two-component sensor/regulator system CsrR/CsrS. The membrane-bound sensor CsrS is thought to respond to previously unknown environmental signal(s) by controlling phosphorylation of its cognate regulator component CsrR. Phosphorylation of CsrR increases its affinity for binding to the promoter regions of Csr-regulated genes to repress transcription. Here we show that environmental Mg2+ concentration is a potent and ...

  15. Study of CSR longitudinal bunch compression cavity

    International Nuclear Information System (INIS)

    The scheme of longitudinal bunch compression cavity for the Cooling Storage Ring (CSR)is an important issue. Plasma physics experiments require high density heavy ion beam and short pulsed bunch,which can be produced by non-adiabatic compression of bunch implemented by a fast compression with 90 degree rotation in the longitudinal phase space. The phase space rotation in fast compression is initiated by a fast jump of the RF-voltage amplitude. For this purpose, the CSR longitudinal bunch compression cavity, loaded with FINEMET-FT-1M is studied and simulated with MAFIA code. In this paper, the CSR longitudinal bunch compression cavity is simulated and the initial bunch length of 238U72+ with 250 MeV/u will be compressed from 200 ns to 50 ns.The construction and RF properties of the CSR longitudinal bunch compression cavity are simulated and calculated also with MAFIA code. The operation frequency of the cavity is 1.15 MHz with peak voltage of 80 kV, and the cavity can be used to compress heavy ions in the CSR. (authors)

  16. IMPLICATIONS OF CSR ON CORPORATE STAKEHOLDERS

    Directory of Open Access Journals (Sweden)

    Crisan Catalina

    2015-07-01

    Full Text Available Companies’ strategies and values must be in accordance to stakeholders’ expectations and needs because their role and influences on companies’ activity are decisive for companies future development. Corporate Social Responsibility is a meaningful way through which companies can pursue sustainable development by having a coherent economical, social and environmental perspective on how the business should be managed. CSR must become an integral part of corporate management system, because it has a major role in distressing the relation between company and major stakeholders, both internally and externally. CSR is a global phenomenon, which draws the attention of a growing number of partisans, from public private and social sector. To demonstrate the applicability of the theoretical approaches deduced from the existing literature, the authors recourse to an empirical qualitative research, conducted through a questionnaire implemented to top managers, HR managers and heads of CSR departments within large companies that operate in Romania. The research is based on the analysis of a number of 87 questionnaires and aims to highlight major stakeholders and finding how companies’ responsible activities can influence stakeholders. This study is designed to highlight how prioritization of stakeholders influences CSR initiatives within large companies that operate in Romania, and to present a perspective of company’s approach towards shared value influence major stakeholders. The conclusions drawn have a greater relevance both theoretically and especially practically because provides insights on how large companies perceive CSR and how stakeholders influence responsible initiatives in emergent country like Romania where stereotypes are difficult to manage.

  17. Usefulness of mammography of mastectomy site for breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Son, Eun Ju; Kim, Eun Kyung; Oh, Ki Keun; Huh, Yong Min; Lee, Kyong Sik; Lee, Hye Jin [Yonsei Univ. College of Medicine, Seoul (Korea, Republic of)

    1998-08-01

    To evaluate the usefulness of routine mammography in the detection of local recurrence of breast cancer after mastectomy. Materials and Methods : The clinical and mammographic records of 45 patients who underwent modified mastectomy due to breast cancer were prospectively reviewed. The methods of mastectomy were Auchincloss (n=36), Patey (n=8) and simple resection (n=1). Results : Among the 45 patients, five palpable lesions were detected on physical examination: two of the five were confirmed as tumor recurrence; on mammography, a nodule with microcalcifications and low-density lesion was seen, but the other three were benign. In 40 patients the results of palpation were negative and during follow-up (mean, 10.9 months ) no newly developed lesions were seen. On mammography, ten of 45(22.2%) patients showed abnormalities, namely local skin thickening(n=4,40%),increased density in subcutaneous tissue(n=2,20%), nodules(n=2,20%), benign calcification(n=1,10%) and focal low-density lesion(n=1,10%), but only one case with a nodule was confirmed to be recurrence. Conclusion : Routine mammography of a mastectomy site was not useful for the differentiation of palpable lesions.

  18. Reviewing CSR management and marketing communication research: A discourse approach

    DEFF Research Database (Denmark)

    Nielsen, Anne Ellerup; Thomsen, Christa

    , corporate reputation and value creation (e.g. Porter & Kramer 2006; Du et al. 2010). By looking at the rapidly growing body of research in the field of CSR management and marketing communication, the paper focuses on the positions, arguments, conflicts and actors of CSR communication across specific CSR...... includes stakeholders in or around business units established in developing countries and emerging markets (e.g. Jamali 2010; Reimann 2012). Along with the growing pressure on corporations to engage in CSR a seemingly growing number of these are concerned with disclosure, reporting, reputation, etc. issues...... extent CSR communication may contribute to influence stakeholders’ perception of corporations’ CSR performance. At best, some studies hold that there is a general recognition of CSR communication as a potential reputation enhancer, but also that if addressed inappropriately, CSR communication cause more...

  19. Consumer perceptions of CSR: (how) is China different?

    OpenAIRE

    Kolk, A.; Dolen, van, W.; Ma, L

    2015-01-01

    Purpose Most studies on consumers and corporate social responsibility (CSR) have focused on Western contexts. Consequently, good insight is lacking into non-Western markets where consumers may respond differently. China is a case in point, despite the popularity of the CSR concept and high societal expectations of firms. The purpose of this paper is to examine how Chinese consumers perceive the underlying components of CSR found in Western countries; whether their CSR expectations differ for ...

  20. Importance of outcomes Measurement of CSR programmes - Case Nokia

    OpenAIRE

    Talvitie-Sirén, Reeta

    2009-01-01

    Abstract: Objectives of the Thesis The objective of the thesis was to find out how companies measure the societal and business outcomes of their CSR activities as well as to find out the reasons why outcomes measurement is considered important. The focus was on the societal aspect of CSR, and all programmes studied were community related CSR programmes. The programmes studied were categorised according to a framework of CSR action types modified from Halme and Laurila (2009). A fourth cate...

  1. Measurement of intensity distribution of CSR in LEBRA PXR beamline

    International Nuclear Information System (INIS)

    Last year, the intensity of Coherent Synchrotron Radiation (CSR) in LEBRA PXR beamline was measured. As a result, it turned out that the intensity of CSR was stronger than anticipation. It is suggested that Coherent Edge Radiation (CER) is mixed with CSR. Then, in order to confirm whether CER is contained, the intensity distribution of CSR was measured. The result of the experiment is reported in this paper. (author)

  2. Empirical Analysis on CSR Communication in Romania: Transparency and Participation

    OpenAIRE

    Irina-Eugenia Iamandi

    2012-01-01

    In the specific field of corporate social responsibility (CSR), the participation of companies in supporting social and environmental issues is mainly analysed and/or measured based on their CSR communication policy; in this way, the transparency of the CSR reporting procedures is one of the most precise challenges for researchers and practitioners in the field. The main research objective of the present paper is to distinguish between different types of CSR participation by identifying the r...

  3. How do Domestic Institutions Influence Corporate Social Responsibility (CSR)?

    OpenAIRE

    Brown, Dana; Steen Kundsen, Jette

    2012-01-01

    The literature explains the link between CSR and domestic institutions in terms of the presence of national institutional complementarities as a key determinant of a company’s CSR initiatives. One set of explanations sees CSR as fitting in with domestic institutional structures as either `substituting’ or ‘mirroring’ government policies. A second set of explanations views CSR as driven by variations in competitive needs across countries, reflecting in particular the degree of international ma...

  4. CEO letters in CSR reports: oil companies in focus

    OpenAIRE

    von Berg, Marhaba

    2013-01-01

    Objectives of the study: A main challenge in planning CSR communication strategy is how to communicate positive motives of a corporation in its CSR activities and how to decrease stakeholder uncertainty. This study provides an analysis of the CEO letters issued by eight oil companies in their CSR reports. The thesis is an investigation of target stakeholder group and move-structure carried out to determine the communicative purpose of CEO letters in CSR reports of eight oil companies. The...

  5. CSR: Transparency and the role of intermediate organisations

    OpenAIRE

    Dubbink, G.W.; Graafland, J.J.; Liederkerke, L.

    2008-01-01

    Transparency is a crucial condition to implement a CSR policy based on the reputation mechanism. The central question of this contribution is how a transparency policy ought to be organised in order to enhance the CSR behaviour of companies. Governments endorsing CSR as a new means of governance have different strategies to foster CSR transparency. In this paper we discuss the advantages and disadvantages of two conventional policy strategies: the facilitation policy and the command and contr...

  6. Consumers’ responses to CSR in a cross-cultural setting

    OpenAIRE

    Hakan Karaosman; Gustavo Morales-Alonso; Mercedes Grijalvo

    2015-01-01

    The paper aims to clarify the relationship between corporate social responsibility (CSR) and consumer behaviour in an international setting. Consumers’ responses to CSR activities and the impact on the purchase decision are limited discourses. CSR-based studies in the fashion and apparel industry are also scarce. Therefore, this study attempts to enlighten the subject of how consumers from different countries respond to CSR adopted in the fashion and apparel industry. This study is based on a...

  7. The radiation protection design of CSR

    International Nuclear Information System (INIS)

    The construction of CSR (Cooling Storage Ring) which include a main ring (CSRm) and an experimental ring (CSRe) will be started in this year. Heavy ions of carbon to uranium will be accelerated up to 900MeV/u and 400MeV/u at intensity of 108 pps. For the shielding design of CSR, the secondary neutron yields due to ion beam loss and their spectra, angular distributions were estimated based on the experimental results for 400 MeV/u 12C+Cu reaction by K. Nakamura et.al.. The equivalent dose at the shield surface and in the surrounding environment, skyshine neutron dose equivalent and air-induced radioactivity were also estimated in this study. It is found that the most important environmental radiation impact component of CSR is the skyshine neutrons, and the environmental impact due to air and cooling water induced radioactivity were lesser. (author)

  8. Liberal CSR and New Marxist Criticism

    DEFF Research Database (Denmark)

    Toft, Kristian Høyer

    2014-01-01

    The term ‘corporate social responsibility’ (CSR) is considered by the new Marxist left to be a self-defeating oxymoron. In this chapter, the new Marxist challenge to CSR as a meaningful, coherent concept and practice is discussed. In the wake of the financial crisis the critique from the Marxist......-inspired left tends to replace the scepticism of the libertarian right (Friedman 1970). The legitimacy of business in society is at stake, and the critical left is well placed to debunk the integrity of business’s claim to social responsibility. To provide an overview of current Marxist inspired CSR thinking......, this chapter introduces the Hegelian inspired critique of a New Spirit of Capitalism (Chiapello 2013) as well as the critique of ideology targeted at the neo-liberal project of corporate responsibility (Žižek 2008; Fleming and Jones 2013). Subsequently, two possible liberal ‘revisions’ to the Marxist inspired...

  9. CSR och politisk konsumtion : - en studie av Nikes och Pumas CSR- rapporter

    OpenAIRE

    Björling, Ameli

    2010-01-01

    CSR and political consumption – a study of Nike’s and Puma’s CSR-reports” The purpose of this dissertation is to examine if political consumption has influenced multinational corporations to improve their Corporate Social Responsibility reports and policies more, than a company who has not been a target for political consumption. This dissertation is a content analysis of Nike’s and Puma’s first (Nike 2001, Puma 2001) and latest (Nike 2007/09, Puma 2007/08) CSR- reports. Archie Carroll’s mod...

  10. Nanshan Aluminum Reached Strategic Cooperation with CSR Corporation Limited

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    As a key supplier of aluminum profiles and aluminum plate,sheet and trip products for CSR Corporation Limited,Nanshan Aluminum will join hands with CSR Corporation Limited to reach strategic cooperation.On January 5,Nanshan Aluminum signed strategic cooperation agreement with CSR Sifang Locomotive&Rolling; Stock Co.,Ltd,both

  11. CSR of Lanzhou and nuclear physics at high densities

    International Nuclear Information System (INIS)

    The possibility to produce highly dense nuclear matter at CSR of Lanzhou and the corresponding signals at final state are discussed. Especially, the maximum baryon density reached at CSR is estimated, and the subthreshold production and hadronic flow risen from the partial restoration of chiral symmetry at CSR energies are analyzed

  12. Implementation: Measuring and Explaining the Fidelity of CSR Implementation

    Science.gov (United States)

    Kurki, Anja; Boyle, Andrea; Aladjem, Daniel K.

    2006-01-01

    Comprehensive school reform (CSR) is only as effective as its implementation. By using data collected for the National Longitudinal Evaluation of Comprehensive School Reform (NLECSR), this article explores the factors that predict CSR model implementation and the ways that CSR model implementation varies. We found little difference in the fidelity…

  13. CsrA Regulates Translation of the Escherichia coli Carbon Starvation Gene, cstA, by Blocking Ribosome Access to the cstA Transcript

    OpenAIRE

    Ashok K Dubey; Baker, Carol S.; Suzuki, Kazushi; Jones, A. Daniel; Pandit, Pallavi; Romeo, Tony; Babitzke, Paul

    2003-01-01

    CsrA is a global regulator that binds to two sites in the glgCAP leader transcript, thereby blocking ribosome access to the glgC Shine-Dalgarno sequence. The upstream CsrA binding site (GCACACGGAU) was used to search the Escherichia coli genomic sequence for other genes that might be regulated by CsrA. cstA contained an exact match that overlapped its Shine-Dalgarno sequence. cstA was previously shown to be induced by carbon starvation and to encode a peptide transporter. Expression of a cstA...

  14. Security of Operation on CSR Control System

    Institute of Scientific and Technical Information of China (English)

    GouShizhe; QiaoWeimin; JingLan

    2003-01-01

    It is important to the security of operation on the CSR control system. In order to keep the CSR control system in security environment, the following work has been done. Firstly, it can be set up a domain service, and every important services can join in it, such as databasese rvices, front web services and every interactive operating browsers, and limited the browsers right by using policy of the domain. After this, the browsers can't modify the setting of the browser, and it can keep every computers and browsers in security by preventing some virus into each computer. The domain services of control system is shown in Fig.1.

  15. How Personal Values Influence Romanian CSR Managers` Involvment in CSR Campaigns

    Directory of Open Access Journals (Sweden)

    Anca Diana ȘERBAN

    2015-12-01

    Full Text Available This study focuses on identifying the ratio between the individual and organization authority of CSR managers concerning decision making within the campaigns they coordinate. The sample includes the top 100 Romanian companies selected by turnover. The way in which the managers’ values interact with the organization authority is a subject treated poorly in both international and Romanian literature. This study, which has an exploratory character, investigates how personal values lead Romanian CSR managers to develop and coordonate CSR campaigns and to what extent these values are part of the campaign messages compared to the values of the company for which they are made. The main results of this scientific paper refers to the correlation between the CSR managers’ values and the campaigns that they coordinate.

  16. Environmental policy and CSR: How climate change is interpreted in CSR reports of Greek companies

    OpenAIRE

    Metaxas, Theodore; Tsavdaridou, Maria

    2014-01-01

    The environmental policy and Corporate Social Responsibility are two notions of high importance for enterprises and nations. Numerous pages have been written about the environmental policy of companies in their CSR reports. Whether it concerns to raise environmental awareness among their employees or local communities or to give in detail their environmental footprint at the end of the story it is about giving proofs of their environmental policy. Climate change is among the topics of CSR rep...

  17. Corporate Social Responsibility (CSR) : a participatory approach to implementing CSR in a cluster

    OpenAIRE

    Høivik, Heidi von Weltzien; Shankar, Deepthi

    2010-01-01

    This report is focused on why and how a participatory approach to implement Corporate Social Responsibility (CSR) in a cluster would be beneficial for Small and Medium-sized Enterprises (SMEs) in the Norwegian Center of Expertise (NCE) Subsea cluster in Bergen, Norway. The political and strategic reasons, as well as internal motivation, for SMEs to incorporate CSR into their business strategies are discussed with support from relevant literature. Furthermore, the report reviews differ...

  18. CSR: Fordrende? Forhindrende? Forandrende? - Et speciale om CSR i små og mellemstore virksomheder

    OpenAIRE

    Gertov, Alexandra Rahbek; Thorarinsson, Lina Kamilla; Villumsen, Anne Katrine Holst Høiberg

    2016-01-01

    This thesis examines the barriers SME’s experience when they try including CSR-initiatives in their business practices. We conduct a qualitative case study of six companies whose narratives we have interpreted through Paul Ricoeur's methods and Karl. E. Weick's sensemaking concepts. Through a phenomenological-hermeneutic method of interpretation, we derived 10 barriers that obstruct the case companies in recognizing opportunities within a CSR-sphere. We conclude that barriers as a concept can...

  19. CSR-communication in the Business Press

    DEFF Research Database (Denmark)

    Morsing, Mette; Langer, Roy

    In this paper we analyze the construction of corporate social responsibility in the business press as an act of strategic ambiguity. While corporate social responsibility (CSR) generally evokes positive associations in public opinion, this paper demonstrates that these associations are based...

  20. CSR Position in the Top Management Team

    DEFF Research Database (Denmark)

    Strand, Robert

    Recently, a number of positions with corporate social responsibility (CSR) in the position title have been introduced to the top management teams (TMTs) of some of the world’s largest corporations. I explore this phenomenon. I revisit 10 such positions identified in a previous study to add a...

  1. CSR observations at the ANKA storage ring

    Energy Technology Data Exchange (ETDEWEB)

    Judin, Vitali; Hiller, Nicole; Hofmann, Andre; Huttel, Erhard; Kehrer, Benjamin; Klein, Marit; Marsching, Sebastian; Meuter, Christina; Mueller, Anke-Susanne; Nasse, Michael Johannes; Schuh, Marcel; Smale, Nigel John; Streichert, Max Igor [Karlsruher Institut fuer Technologie, Karlsruhe (Germany)

    2012-07-01

    ANKA is a synchrotron light source situated at the Karlsruhe Institute of Technology. Using dedicated low-{alpha}-optics at ANKA we can reduce the bunch length and generate Coherent Synchrotron Radiation (CSR). Studies of the coherent emission in the time domain and spectral measurements in the THz range allow us to gain insight into the longitudinal bunch dynamics.

  2. HIRFL–CSR internal cluster target

    International Nuclear Information System (INIS)

    Highlights: • An internal cluster target was built and installed at HIRFL–CSR. • The target thickness for H2 amounts up to 6.6 × 1012 atoms/cm2. • The feasibility and stability of the internal cluster target were verified by on-line experiments. -- Abstract: Since HIRFL–CSR internal cluster target was built, it has played a key role in in-ring experiments at HIRFL–CSR. So far it have been operated with five gas species as targets for scattering experiments, i.e. hydrogen, nitrogen, argon, neon, and krypton. The obtained highest thickness for hydrogen target amounts up to 1012 atoms/cm2, and those of other targets are larger than 1013 atoms/cm2 with the background pressure of 10−11 mbar in CSR. The target thickness can be varied by regulating the nozzle temperature and pressure of the inlet gas. The first online internal target experiment dedicated to investigate radioactive electron capture (REC) process with Xe54+ ions colliding with the nitrogen target demonstrated the stability and reliability of the internal target system. In addition, hydrogen and krypton were also tested online in recent experiments, which indicate the target system can meet experimental requirements for the thickness of target, pressure in scattering chamber, and long-term stability

  3. A Public Governance Look at CSR

    DEFF Research Database (Denmark)

    Buhmann, Karin

    2014-01-01

    parameters combine with normative guidance based on CSR norms (e.g. the UN Global Compact, OECD’s Guidelines for Multinational Enterprises, the UN Guidelines on Business and Human Rights). Focusing on debates concerning resource extraction operations in Greenland and the pertinent policy framework...

  4. Governmentality and the Politics of CSR

    DEFF Research Database (Denmark)

    Vallentin, Steen; Murillo, David

    2012-01-01

    ) promotes a strategic understanding of CSR as a lever for economic competitiveness and growth and b) disregards regulatory measures in favour of liberal and indirect means of steering. We argue that the analytical vocabulary of governmentality makes it possible to address and problematize the indirect modes...

  5. Rectal and colon cancer : Not just a different anatomic site

    NARCIS (Netherlands)

    Tamas, K.; Walenkamp, A. M. E.; de Vries, E. G. E.; van Vugt, M. A. T. M.; Beets-Tan, R. G.; van Etten, B.; de Groot, D. J. A.; Hospers, G. A. P.

    2015-01-01

    Due to differences in anatomy, primary rectal and colon cancer require different staging procedures, different neo-adjuvant treatment and different surgical approaches. For example, neoadjuvant radiotherapy or chemoradiotherapy is administered solely for rectal cancer. Neoadjuvant therapy and total

  6. Case Study of the Development of CSR in Danfoss

    DEFF Research Database (Denmark)

    Ma, Rufei; Toh, ImnLin; Christensen, Per;

    ”, “Volunteering” as CSR Modes. Its positive learning capacity is a contributing factor to its conducive environment for CSR to flourish. The development of CSR in Danfoss was a gradual progression influenced by its concern for its employees, environmental and labour market issues, and its commitment to the UN......This work‐in‐progress focuses on the CSR practice within the Danfoss Group, a leading global manufacturing company based in Denmark. Its mechanism in CSR policy making and its learning capacity in reaction to changes that may be caused by major events (climate change and the current financial...... questionnaire surveys with those at management level and also to the general employees. The outcome of the research shows that Danfoss is at an advanced stage of CSR development. It is engaging more in the second and third CSR waves (Products & Processes and Employee Relations), using “Foundation...

  7. Are sites with multiple single nucleotide variants in cancer genomes a consequence of drivers, hypermutable sites or sequencing errors?

    Science.gov (United States)

    Carr, Antony M.

    2016-01-01

    Across independent cancer genomes it has been observed that some sites have been recurrently hit by single nucleotide variants (SNVs). Such recurrently hit sites might be either (i) drivers of cancer that are postively selected during oncogenesis, (ii) due to mutation rate variation, or (iii) due to sequencing and assembly errors. We have investigated the cause of recurrently hit sites in a dataset of >3 million SNVs from 507 complete cancer genome sequences. We find evidence that many sites have been hit significantly more often than one would expect by chance, even taking into account the effect of the adjacent nucleotides on the rate of mutation. We find that the density of these recurrently hit sites is higher in non-coding than coding DNA and hence conclude that most of them are unlikely to be drivers. We also find that most of them are found in parts of the genome that are not uniquely mappable and hence are likely to be due to mapping errors. In support of the error hypothesis, we find that recurently hit sites are not randomly distributed across sequences from different laboratories. We fit a model to the data in which the rate of mutation is constant across sites but the rate of error varies. This model suggests that ∼4% of all SNVs are errors in this dataset, but that the rate of error varies by thousands-of-fold between sites.

  8. The Current State of CSR Consultancy Development in Russia and the United Kingdom

    OpenAIRE

    Armley, Natasha

    2005-01-01

    The research examines the phenomenon of corporate social responsibility (CSR) consultancy in Russia, as a new growing market, in comparison with well defined CSR consultancy in the UK, more advanced in CSR traditions and practices. The introduction to CSR consultancy has been made through a prism of CSR definitions: how it is interpreted in the West and Russia. Significant attention has been paid to analysing the UK and Russia national CSR systems combining the major drivers of CSR develo...

  9. Comparison analysis between CSR-OT and CSR-H for corrugated bulkhead of large product tankers

    Institute of Scientific and Technical Information of China (English)

    蔡诗剑; 邱伟强; 刘奕谦

    2014-01-01

    Large Aframax product tanker (more than 100k DWT), with centerline longitudinal corrugated bulkheads and transverse corrugated bulkheads in cargo area, is the largest type of product tanker at present. The external draft of Harmonized Common Structural Rules (CSR-H) for Bulk Carriers and Oil Tankers is released for external review. More attentions are paid to the impact of CSR-H on the structural design of the corrugated bulkhead of large Aframax product tankers. Based on CSR-OT and CSR-H, it discusses the impact of CSR-H on the corrugated bulkhead by strength assessment of a 115k DWT product tanker.

  10. Plasma Protein Carbonyls and Breast Cancer Risk in Sisters Discordant for Breast Cancer from the New York Site of the Breast Cancer Family Registry

    OpenAIRE

    Zipprich, Jennifer; Terry, Mary Beth; Liao, Yuyan; Agrawal, Meenakshi; Gurvich, Irina; Senie, Ruby; Santella, Regina M.

    2009-01-01

    Reactive Oxygen Species (ROS) are important in the pathogenesis of many diseases, including breast cancer. Several population-based case-control studies have demonstrated that various biomarkers of oxidative stress are associated with an increase in breast cancer risk. We selected sisters discordant for breast cancer (n=645) from the New York site of the Breast Cancer Family Registry to explore factors that contribute to variation in plasma protein carbonyls, and to determine whether this bio...

  11. Port-site metastasis following robotic-assisted radical hysterectomy for squamous cell cervical cancer

    OpenAIRE

    Bolles, Olivia; Borowsky, Mark

    2011-01-01

    ► Port-site metastases can occur following treatment for cervical cancer. ► Port-site metastases can occur following robotic assisted laparoscopic surgery. ► The pathogenesis of port-site metastases is poorly understood.

  12. csrA Inhibits the Formation of Biofilms by Vibrio vulnificus▿

    OpenAIRE

    Jones, Melissa K.; Warner, Elizabeth B.; Oliver, James D.

    2008-01-01

    PCR screening of the shellfish-borne pathogen Vibrio vulnificus revealed csrA-negative strains, and these strains formed increased biofilm compared to csrA-positive strains. Complementation in trans with csrA resulted in reduced biofilm formation, similar to that by csrA+ strains. Our results provide evidence that csrA inhibits biofilm formation in V. vulnificus.

  13. Leukemia after radiotherapy for first primary cancers of various anatomic sites

    Energy Technology Data Exchange (ETDEWEB)

    Boivin, J.F.; Hutchison, G.B.; Evans, F.B.; Abou-Daoud, K.T.; Junod, B.

    1986-06-01

    The authors conducted a case-control study designed to evaluate the association between radiotherapy for a first primary cancer and subsequent leukemia risk. Study subjects were selected from four tumor registries (California, Connecticut, Kansas, and Massachusetts). Cases were subjects with two primary concers; the second cancer was a leukemia diagnosed one year or more after the diagnosis of the first primary cancer. Control subjects were patients with single cancers. Two control subjects were chosen for each case matched for tumor registry, site of the first primary cancer, date of diagnosis of the first primary cancer, age, sex, and duration of survival after the first primary cancer. Separate analyses were carried out for chronic lymphatic leukemia (166 cases) and all other leukemias (232 cases). The relative risk of chronic lymphatic leukemia after radiotherapy was 0.7 and did not differ significantly from unity. For all other leukemias, relative risks were 1.6 after radiotherapy for first primary cancers of all sites, 2.4 after radiotherapy to trunk sites, 2.2 after radiotherapy for breast cancer, and 10.3 after radiotherapy for cancer of the corpus uteri. These relative risks for leukemias other than chronic lymphatic leukemia all differed significantly from unity.

  14. Risk Prediction Models for Other Cancers or Multiple Sites

    Science.gov (United States)

    Developing statistical models that estimate the probability of developing other multiple cancers over a defined period of time will help clinicians identify individuals at higher risk of specific cancers, allowing for earlier or more frequent screening and counseling of behavioral changes to decrease risk.

  15. HIRFL-CSR internal target system

    International Nuclear Information System (INIS)

    The structure and the design of the HIRFL-CSR internal target system is reported. The HIRFL-CSR internal target can operate in two modes: cluster target mode and polarized target mode. The cluster target may provide the gas target of H2, N2, noble gases and small molecular gases with a density of ≥ 1013 atoms/cm2, and the polarized target may provide polarized H and D beams with a density of about 2 x 1011 atoms/cm2. The target polarization is expected to be +0.90/-0.90 for hydrogen beam, and the vector polarization is expected to +0.95/-0.95 for deuterium beam

  16. Electron cooling performance at HIRFL-CSR

    International Nuclear Information System (INIS)

    In order to investigate the one-dimensional beam ordering in HIRFL-CSR, the ion beam of 58Ni19+ with the energy of 6.39 MeV/u was accumulated in the main ring of HIRFL-CSR with the help of electron cooling. The maximum accumulated ion beam intensity in the 10 seconds was measured, and the lifetime of ion beams was measured. The momentum spread of the ion beam varying with the particle number was measured during the ion beam decay, the power exponent was derived from these data, in additional, the momentum spread in the case of a constant particle number was plotted with the angle between ion and electron beams and electron beam profile. The oscillation and shift of the central frequency of the ion beam were observed during the experiments when the angle was large. (authors)

  17. Vliv CSR aktivit na reputaci firmy

    OpenAIRE

    Oberreiter, Štěpán

    2008-01-01

    Hlavním cílem této bakalářské práce je posouzení vlivu CSR(Corporate Social Responsibility-do čestiny přeloženo jako společenská odpovědnost firem) na reputaci firmy. V práci krátce představím historický vývoj CSR, současný stav a přiblíží též různé metody měření těchto aktivit. Dalším cílem práce je posoudit, jestli se jedná v případě těchto aktivit o náklad, či o investici.

  18. Welfare mix, CSR and social citizenship

    OpenAIRE

    Moreno Fernández, Luis

    2010-01-01

    Corporate Social Responsibility (CSR) is an important undertaking by corporations in order to advance social citizenship. In the last decades a growing implication of businesses and NGOs in welfare development has run hand in hand with a noticeable increase of both: (a) the for-profit welfare provision of policies and services to the general public, and (b) those programmes made available by corporations to their employees. All these developments, together with the provision of social poli...

  19. CSR in International Business - Creating Shared Value

    OpenAIRE

    Fjell, Lise; Rødland, Silje Erdal

    2015-01-01

    The world is experiencing several global issues of economic, social, cultural, and humanitarian characters, and they are continuously increasing in scale. Multinational corporations (MNCs) are considered as both contributors to the problems, but also as a big part of the solutions. Consequently, the pressure put on firms to take responsibility for their actions is increasing, and corporate social responsibility (CSR) has emerged as an inescapable priority for managers. However, MNCs investme...

  20. Corporate Social Responsibility (CSR) and energy industry

    International Nuclear Information System (INIS)

    What means Corporate Social Responsibility (CSR) in the energy industry? A rising energy demand with limited natural resources pose utilities, industry and consumers with new challenges. This book follows an interdisciplinary approach and for the first time brings together debates and findings from industry, science, politics, culture and media. Because the energy transition can only succeed if it is comprehensible for the individual and fragmented perspectives and interests are merged.

  1. HIRFL-CSR electron cooling system

    International Nuclear Information System (INIS)

    Electron cooling technique will be applied to the proposed Lanzhou heavy ion cooler-storage ring (HIRFL-CSR). A electron cooling device with a maximum electron energy of 165 keV and maximum current density of 0.244 A/cm2 is planned to cool heavy ions up to energies of 300 MeV/u. The preliminary design for the cooling system is presented

  2. Animal Welfare: A Dilemma for Japanese CSR?

    OpenAIRE

    Mizuta, Wakako

    2010-01-01

    ABSTRACT This paper seeks to analyse whether animal welfare issues can be one of concerns for Japanese companies to formulate CSR strategy. Today, the subject of animal welfare is becoming one of important global issues since European Union regulates the issues and its regulations are becoming stricter. Japanese companies would face on the issues in the EU and global market. However, since there is distinct public concern for the issues in Japan, it is questionable if and how Japanese com...

  3. CSR - nejen zelený reporting

    OpenAIRE

    Trunkát, Michal

    2011-01-01

    The topic of this diploma thesis is a Corporate Social Responsibility concept. The thesis is primarily focused on Corporate social responsibility reporting of companies located in the Czech Republic which is nowadays based on voluntary approach. The author compares CSR reports with GRI standards that currently represent respected framework for responsible reporting. The primary aim of GRI with assistance of G3 guidelines is to create unified, compact and transparent directions for GRI reporti...

  4. The Economic Virtues of SRI and CSR

    OpenAIRE

    Derwall, Jeroen

    2007-01-01

    textabstractFinancial markets and company managers are increasingly acknowledging the concepts of socially responsible investing (SRI) and corporate social responsibility (CSR), but not without reservations. These hesitations are largely attributable to ongoing debates about a potential conflict between social responsibility goals and the traditional financial objectives of investors and companies. This thesis bundles six empirical studies that deepen our understanding of the economic value o...

  5. HIRFL-CSR internal cluster target

    Science.gov (United States)

    Shao, Caojie; Lu, Rongchun; Cai, Xiaohong; Yu, Deyang; Ruan, Fangfang; Xue, Yingli; Zhang, Jianming; Torpokov, D. K.; Nikolenko, D.

    2013-12-01

    Since HIRFL-CSR internal cluster target was built, it has played a key role in in-ring experiments at HIRFL-CSR. So far it have been operated with five gas species as targets for scattering experiments, i.e. hydrogen, nitrogen, argon, neon, and krypton. The obtained highest thickness for hydrogen target amounts up to 1012 atoms/cm2, and those of other targets are larger than 1013 atoms/cm2 with the background pressure of 10-11 mbar in CSR. The target thickness can be varied by regulating the nozzle temperature and pressure of the inlet gas. The first online internal target experiment dedicated to investigate radioactive electron capture (REC) process with Xe54+ ions colliding with the nitrogen target demonstrated the stability and reliability of the internal target system. In addition, hydrogen and krypton were also tested online in recent experiments, which indicate the target system can meet experimental requirements for the thickness of target, pressure in scattering chamber, and long-term stability.

  6. CSR in the Aftermath of the Financial Crisis

    DEFF Research Database (Denmark)

    Lauesen, Linne Marie

    2013-01-01

    of Schwartz and Carroll’s ‘Three-­domain CSR-­model’, which the Principle extends and revises to: Economy, L/Egal, Environment, and Ethics. This Principle disentangles the dialectic relationship between economic and social responsibility; takes financial products into a consideration; refines the definitions......Purpose – The purpose of the paper is to examine the literature of CSR before and in the aftermath of the financial crisis in 2008. The aim of the research question is to map out the consequences upon CSR derived from the crisis and to derive new principles of future CSR models to come consistent...... with the consequences of the financial crisis, and to suggest new research as well as policy-­‐making possibilities to highlight the importance and necessary survival of CSR as an instrument for sustainable and financial progress. Design/methodology/approach – The paper uses a literature review of CSR prior...

  7. CSR in the Aftermath of the Financial Crisis

    DEFF Research Database (Denmark)

    Lauesen, Linne Marie

    2013-01-01

    's “Three-domain CSR-model”, which the Principle extends and revises to: Economy, L/Egal, Environment, and Ethics. This Principle disentangles the dialectic relationship between economic and social responsibility; takes financial products into consideration; refines the definitions of good stakeholder......Purpose – The purpose of this paper is to examine the literature of CSR before and in the aftermath of the financial crisis in 2008. The aim of the research question is to map out the consequences upon CSR derived from the crisis and to derive new principles of future CSR models to come consistent...... with the consequences of the financial crisis, and to suggest new research as well as policy-making possibilities to highlight the importance and necessary survival of CSR as an instrument for sustainable and financial progress. Design/methodology/approach – This paper uses a literature review of CSR prior to and after...

  8. Intragenic recombination in the CSR1 locus of Arabidopsis.

    Science.gov (United States)

    Mourad, G; Haughn, G; King, J

    1994-04-01

    Four classes of herbicides are known to inhibit plant acetolactate synthase (ALS). In Arabidopsis, ALS is encoded by a single gene, CSR1. The dominant csr1-1 allele encodes an ALS resistant to chlorsulfuron and triazolopyrimidine sulfonamide while the dominant csr1-2 allele encodes an ALS resistant to imazapyr and pyrimidyl-oxy-benzoate. The molecular distance between the point mutations in csr1-1 and csr1-2 is 1369 bp. Here we used multiherbicide resistance as a stringent selection to measure the intragenic recombination frequency between these two point mutations. We found this frequency to be 0.008 +/- 0.0028. The recombinant multiherbicide-resistant allele, csr1-4, provides an ideal marker for plant genetic transformation. PMID:8177214

  9. CSR jako przedsięwzięcie biznesowe

    Directory of Open Access Journals (Sweden)

    Szymon Wierciński

    2011-04-01

    Full Text Available Niniejszy artykuł poświęcony jest relacji między programami społecznej odpowiedzialności biznesu a wynikami finansowymi organizacji (CSR – CFP. Podążając za nurtem badaczy poszukujących biznesowego uzasadnienia dla CSR, autor przedstawia problemy i wyzwania stojące przed menedżerami i naukowcami, dotyczące mierzenia efektywności programów CSR. Przegląd literatury prowadzi do zwrócenia szczególnej uwagi na problem związany z precyzyjnym mierzeniem wpływu CSR na różnych poziomach organizacji i propozycji sklasyfikowania działań CSR na podstawie ich efektywności, celem usprawnienia i rozwijania programów CSR w kierunku wspólnych korzyści społeczno-biznesowych.

  10. Adapting the Content of Cancer Web Sites to the Information Needs of Patients: Reliability and Readability

    OpenAIRE

    Alba-Ruiz, Ruben; Bermúdez-Tamayo, Clara; Pernett, Jaime Jiménez; Garcia-Gutierrez, Jose Francisco; Cózar-Olmo, José Manuel; Valero-Aguilera, Beatriz

    2013-01-01

    Background: People who use the Internet to research health topics do not usually find all the information they need and do not trust what they read. This study was designed to assess the reliability, accessibility, readability, and popularity of cancer Web sites in Spanish and to analyze the suitability of Web site content in accordance with the specific information needs of cancer patients. Materials and Methods: This was a two-phase, cross-sectional, descriptive study. The first ph...

  11. Materiality Analysis for CSR Reporting in Spanish SMEs

    OpenAIRE

    Elena Escrig-Olmedo; Raul Leon-Soriano; Juana Maria Rivera-Lirio; Maria Angeles Fernandez-Izquierdo; Maria Jesus Muñoz-Torres,; Idoya Ferrero-Ferrero

    2013-01-01

    Most corporate social responsibility (CSR) standards have not been designed to be implemented in small and medium sized enterprises (SMEs). Given that 99% of Spanish companies are SMEs, this study aims to propose a selection of basic CSR material issues that, because of their usefulness and significance, should be adapted to Spanish SMEs and their stakeholders. This study provides a CSR model for SMEs that includes the most important social, environmental, and corporate governance issues. Thi...

  12. CSR and market changing product innovations: Indian case studies

    OpenAIRE

    Ramani, S.V.; Mukherjee, V.

    2010-01-01

    Do firms need to sacrifice profit while innovating in order to further social objectives, as corporate social responsibility (CSR) would seem to suggest? To answer this question, the paper compiles a classification of innovations according to market impact and CSR potential. Then it details case studies of two market changing (MC) innovations in India: genetically modified cotton of Monsanto and a drugs cocktail for HIV/AIDS of Cipla. It demonstrates that the CSR potential of an MC innovation...

  13. Problems and Prospects of CSR System Development in China

    OpenAIRE

    Jie Wang; Sheng Qin; Yanjuan Cui

    2010-01-01

    Corporate Social Responsibility (CSR) reporting system is the system to disclosure the institutions andorganizations influence on the environment, economy and society to the public. It is a great improvement of CSRthat has been issued by advanced enterprises. However the CSR development is still unbalance in China, half ofthem are in the initial stage. The whole level of CSR is not high and the disclosure breadth and depth are notdeep to cover the stakeholder requirements and corporate value....

  14. Towards a convergent institutional perspective on corporate social responsibility (CSR)

    OpenAIRE

    Blindheim, Bjørn-Tore

    2010-01-01

    The research reported in this thesis has been directed by three interconnected questions: 1) How can institutional theory contribute to our understanding of the contingent nature of CSR and manifestations of CSR within national-level fields? 2) What are the potential institutional and political implications of CSR? and 3) How can institutional theory contribute to discussions of a justified foundation for companies (political) efforts on the societal arena? Since the 1950...

  15. Why Enforcing Corporate Social Responsibility (CSR) is Morally Questionable

    OpenAIRE

    Masaka, Dennis

    2008-01-01

    Docketed literature on Corporate Social Responsibility (CSR) exhibits heated contentions on the nature of business-society relations. This paper seeks to explore this contentious issue in the light of contemporary incorporation of CSR in business strategic plans. It notes that enforcing CSR on business might lead to its manipulation to advance corporate organisations’ purely self-interested ends rather than pursuing intrinsic philanthropic activities for the good of society. An insig...

  16. The role and dynamics of CSR in Swiss SMEs.

    OpenAIRE

    Looser, Stéphanie

    2016-01-01

    Corporate Social Responsibility (CSR) frameworks worldwide have been dominated by the concerns and needs of large companies whose highly formalised CSR management systems often failed in previous years to prevent anti-social and illegal behaviour. Thus, there is growing interest in informal processes, relationships and organisational cultures – and corresponding business models – that embed and exemplify CSR. It is proposed that detailed study of Small and Medium-sized Enterprises (SMEs) with...

  17. HUBUNGAN CORPORATE SOCIAL RESPONSIBILITY (CSR) DENGAN KINERJA PERUSAHAAN

    OpenAIRE

    Sundari, Sri

    2015-01-01

    Corporate Social Responsibility (CSR) is the company's commitment to participate in the sustainable economic development to improve the quality of life and environmental benefits the company itself, local community, and society in general. CSR is an important element for the success of the company and can provide benefits to the company. The Company will endeavor to carry out CSR activities that will contribute to internal and external stakeholders. Companies that have a high social performan...

  18. Consumer reactions to different forms of CSR communication

    OpenAIRE

    Buden, Ivana; Connett, Louise

    2016-01-01

    Aim Companies around the world are making sizeable investments into CSR initiatives, but ensuring appropriate returns on these investments remains challenging. Therefore, it is of value to study the communication of corporate CSR efforts. The purpose of this study is to investigate how consumers react to rational versus emotional message strategies in CSR communication. Two categories of consumer reactions were considered: trust and purchase intention. Methods Qualitative research with four f...

  19. Pengaruh Implementasi Corporate Social Responsibility (CSR) terhadap Profitabilitas Perusahaan Perkebunan

    OpenAIRE

    Barus, Riantri

    2015-01-01

    Corporate Social Responsibility (CSR) can be defined as a business organization responsible for the impact of their activities on customers, suppliers, employees, shareholders, communities and other stakeholders as well as the environment, which is known as the triple bottom line (profit, planet and people). However, there are many companies implemented their CSR only on public assistance programs and not integrated with the company's core business. Theoretically, if company doing their CSR a...

  20. CSR aktivity ve vybrané firmě

    OpenAIRE

    Vlková, Petra

    2013-01-01

    The aim of this thesis is to evaluate the CSR strategy of the company Vaisala, together with its existing CSR activities, and to identify opportunities for modification of this strategy and these activities. Vaisala is a global leader in environmental and industrial measurement operating worldwide. Furthermore, this thesis answers the research question on whether Vaisala's activities within its CSR strategy are currently sufficient. The paper is divided into three main chapters. The first cha...

  1. Determinants of corporate social responsibility (CSR). Implementation in companies

    OpenAIRE

    Chodyński, Andrzej; Huszlak, Wojciech

    2014-01-01

    Praca recenzowana / peer-reviewed paper Growing number of businesses are incorporating social responsibility (CR) into their strategy. Businesses notice a number of benefits of CSR implementation. In the literature, there is lack of knowledge regarding the circumstances and conditions affecting CSR implementation. The aim of the present article is to attempt to determine the conditions affecting successful implementation of CSR in companies. The research method which we used is...

  2. CSR Driven Brand Marketing: The Case of Toms

    OpenAIRE

    Mensah, Doris

    2016-01-01

    This research investigates the concept of Corporate Social Responsibility and Branding and how organizations can integrate CSR initiatives with strategic brand management. The project analyzed and discussed Toms Group CSR activities in West Africa more especially in Ghana in relation to child labor and the conditions of cocoa farmers and what the company is doing in terms of CSR strategy that can benefit the brand of the company. The study empirically made semi-structured interviews with t...

  3. RESPONSIBLE BEHAVIOUR OR BUSINESS? SOCIAL RESPONSIBILITY (CSR) IN SPORT MANAGEMENT

    OpenAIRE

    Molnar, G.; Rathonyi-Odor, K.; Borbely, Akos

    2013-01-01

    CSR has become increasingly important in today’s business world and managers must consider not only the economic results of their decisions but also the legal, ethical, moral, and social impact and repercussions of each of their decisions. Some multinational companies’ CSR activities even clearly represent applicability of CSR in sport management. The aim of this study was to do a critical comparative analysis, present the changes, alterations in the traditional company philosophy, object...

  4. CSR BALANCED SCORECARD SYSTEMS AND BUSINESS PERFORMANCES: SMEs CASE STUDY

    OpenAIRE

    Edward Sek Khin Wong; Rusnah Muhamad; Lau Wee Yeap

    2016-01-01

    This paper aims to examine the performance measurement using the CSR Balanced Scorecard system in SMEs firms in Malaysia. It investigates the relationships of the four perspectives of CSR Balanced Scorecard system toward performance measurement. The purpose of this paper is to in- vestigate whether or not the improvement of the non-financial CSR measures will lead to the im- provement of performance measures. To test these relationships, data were collected using the four perspectives approac...

  5. Determinants of voluntary CSR disclosure: Empirical evidence from Germany

    OpenAIRE

    Gamerschlag, Ramin; Möller, Klaus; Verbeeten, Frank

    2011-01-01

    textabstractCurrently, companies spend a great deal of effort on Corporate Social Responsibility (CSR) disclosures. CSR disclosure relates to the provision of information on companies' environmental and social performance. From an economic perspective, companies might disclose this information to avoid or decrease potential political costs. We construct a CSR disclosure index based on the Global Reporting Initiative (GRI) guidelines. Using content analysis, we analyze 130 listed German compan...

  6. Strategic CSR Innovation - Serving Societal and Individual Needs

    OpenAIRE

    Midttun, Atle

    2009-01-01

    This report explores the challenges and opportunities of strategic CSR, and is primarily based on three cases of CSR-driven innovation in Norway. The study has been undertaken within the framework of a project on CSR-driven innovation organised and partially financed by the Nordic Innovation Centre and carried out by the business schools in the four Nordic capitals. Copenhagen Business School; BI – Norwegian School of Management, Helsinki School of Economics, Reykjavik Business University, St...

  7. CSR in the SuperKEKB Damping Ring

    International Nuclear Information System (INIS)

    Coherent synchrotron radiation (CSR) is generated when a bunched beam traverses a dipole magnet or a wiggler/undulator. It can degrade the beam quality in both storage rings and linacs through enhancing the beam energy spread and lengthening the bunch length, even cause single-bunch microwave instabilities. Using several methods, CSR impedances in the positron damping ring (DR) of the SuperKEKB which is under design were calculated. From the impedances due to CSR, resistive wall and various vacuum components, quasi-Green function wake potentials were constructed and used in simulations of Particle-In-Cell (PIC) tracking. We present the CSR related results in this paper.

  8. Polymorphisms in miRNA binding site: new insight into small cell lung cancer susceptibility

    Institute of Scientific and Technical Information of China (English)

    Hong-yu LIU; Jun CHEN

    2011-01-01

    Lung cancer is a leading cause in cancer-related deaths with less than 15% five-year survival worldwide.Small cell lung cancer (SCLC),which accounts for about 15%-18% of lung cancer,carries the worst prognosis within the lung cancer patients.SCLC differs from other lung cancers,so called non-small cell lung cancers (NSCLCs),in the specifically clinical and biologic characteristics.It exhibits aggressive behavior,with rapid growth,early spread to distant sites.Although exquisite sensitive to chemotherapy and radiation,SCLC recurs rapidly with only 5% of patients surviving five years and frequent association with distinct paraneoplastic syndromes[1].

  9. Corporate Social Responsibility (CSR) v spoločnosti Danone a.s.

    OpenAIRE

    Petroniová, Lucia

    2009-01-01

    This thesis deals with theme Corporate Social Responsibility (CSR). Theoretical part provides a comprehensive view of CSR. After the initial definitions of CSR work continues with the historical overview of CSR performance, the benefits of implementing CSR activities, explains the concept of "stakeholders", stresses the importance of communication of CSR activities and finishes with perception of social responsibility by individuals and companies. The practical part introduces specific intern...

  10. Can a Finnish SME gain competitive advantage through strategic CSR. : in the case of Finbow Ltd.

    OpenAIRE

    Hainari-Maula, Lotta

    2015-01-01

    The thesis is researching if a Finnish small and medium-sized enterprise (SME) can gain competitive advantage through strategic corporate social responsibility (CSR). In order to give an understanding of the broad concept of CSR, the research starts with a theory section consisting of a definition of CSR, followed by a discussion of the two main differing views of CSR. Then the concept of strategic CSR is introduced, and the relation between CSR and SMEs is discussed. In the case st...

  11. Radon distribution measurement of Lugo Coal Mine by CSR track detection

    International Nuclear Information System (INIS)

    We discuss relationship between the Alpha radioactivity derived from Uranium and Thorium natural radioactive systems, especially from Radon and the safe production in coalmine region. The Alpha radioactive distributions of different sites were detected and measured by using CSR technique in Lugo Coalmine. Measurement shows that the radon density distributions under the ground is less than that on the ground under today's productive condition in a large area in Henan Lugo coalmine. (author)

  12. Epidemiology of upper gastrointestinal cancers in Iran: A Sub site analysis of 76t cases

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    AIM: To define the sub site distribution of upper gastrointestinal cancers in three provinces of Tran. METHODS: The study was carried out in three provinces in Tran: Ardabil, Golestan, and Tehran. Tn Arbabil and Golestan, the data was collected from the sole referral center for gastrointestinal cancers and the local cancer registry. For Tehran province, data from two major private hospitals were used. All gastric and esophageal cancer patients diagnosed during the period from September 2000 and April 2002 were included in the study. RESULTS: A total of 761 patients with upper gastrointestinal cancers were identified, 314 from Ardabil, 261 from Golestan, and 186 from Tehran. In Tehran, the relative rate of cancer increased from the upper esophagus to the distal stomach. In Golestan, the reverse pattern was observed. In Ardabil, the mid portion (distal esophagus and proximal stomach) was involved most frequently. CONCLUSION: There were considerable variations in the sub site of upper gastrointestinal cancers in the three provinces studied. We cannot provide any explanation for this variation. Further research aimed at explaining the discrepancies in sub site distribution of upper gastrointestinal cancers may help identify important risk factors.

  13. Mutational Biases Drive Elevated Rates of Substitution at Regulatory Sites across Cancer Types.

    Science.gov (United States)

    Kaiser, Vera B; Taylor, Martin S; Semple, Colin A

    2016-08-01

    Disruption of gene regulation is known to play major roles in carcinogenesis and tumour progression. Here, we comprehensively characterize the mutational profiles of diverse transcription factor binding sites (TFBSs) across 1,574 completely sequenced cancer genomes encompassing 11 tumour types. We assess the relative rates and impact of the mutational burden at the binding sites of 81 transcription factors (TFs), by comparing the abundance and patterns of single base substitutions within putatively functional binding sites to control sites with matched sequence composition. There is a strong (1.43-fold) and significant excess of mutations at functional binding sites across TFs, and the mutations that accumulate in cancers are typically more disruptive than variants tolerated in extant human populations at the same sites. CTCF binding sites suffer an exceptionally high mutational load in cancer (3.31-fold excess) relative to control sites, and we demonstrate for the first time that this effect is seen in essentially all cancer types with sufficient data. The sub-set of CTCF sites involved in higher order chromatin structures has the highest mutational burden, suggesting a widespread breakdown of chromatin organization. However, we find no evidence for selection driving these distinctive patterns of mutation. The mutational load at CTCF-binding sites is substantially determined by replication timing and the mutational signature of the tumor in question, suggesting that selectively neutral processes underlie the unusual mutation patterns. Pervasive hyper-mutation within transcription factor binding sites rewires the regulatory landscape of the cancer genome, but it is dominated by mutational processes rather than selection. PMID:27490693

  14. Post-Transcriptional Regulation by the Csr Global Regulatory System in Escherichia coli

    OpenAIRE

    Suzuki, Kazushi; 鈴木, 一史

    2007-01-01

    In many species of bacteria, the Csr (carbon storage regulator) global regulatory system coordinates the expression of various genes. In Escherichia coli, the central component of this system, CsrA, is a RNA-binding protein. The CsrA is a homodimer and binds to leader segments of target mRNAs, affecting their translation and stability. CsrA activity is regulated by two small non-coding RNAs, CsrB and CsrC. These RNAs contain multiple CsrA-binding sequences and act by sequestering CsrA. In thi...

  15. Establishment of CSR Matter-Element Evaluation Model in Perspective of Low Carbon Economy in China

    Directory of Open Access Journals (Sweden)

    Li Furong

    2013-06-01

    Full Text Available With the development of CSR concept, more and more enterprises begin to bring CSR into practice. Especially in the era of low-carbon economy develops quickly, CSR practice is going to mature. In order to make a scientific evaluation on CSR and promote the comprehensive development of CSR, this study develop a new CSR evaluation model under requires of low-carbon economy development. This CSR evaluation model combined G1 weighting method with the Matter-Element Model and finally verified by an example. What we do in this study will provide a good guidance for the development of CSR evaluation and practices.

  16. CSR and skepticism: the influence of fit and reputation on skepticism towards CSR communications

    NARCIS (Netherlands)

    W.J.L. Elving

    2010-01-01

    PURPOSE Consumers tend to be skeptic sometimes towards CSR outlets or communication of companies. In this experiment we tested the influence of fit and reputation on consumer skepticism when confronted with a Cause Related Marketing advertisement. DESIGN In a two (Fit versus no Fit) by three (bad re

  17. Cancer trends in Kashmir; common types, site incidence and demographic profiles: National Cancer Registry 2000-2012

    Directory of Open Access Journals (Sweden)

    M A Wani

    2014-01-01

    Full Text Available Background: An assessment of cancer incidence in population is required for prevention, early diagnosis, treatment and resource allocation. This will also guide in the formation of facilities for diagnosis, treatment, rehabilitation and follow-up for these patients. The demographic trend of cancer will help to identify common types and etiological factors. Efforts at clinical, research and administrative levels are needed to overcome this problem. Settings and Design: Present retro prospective study was conducted in regional cancer center of a tertiary care hospital. Materials and Methods: After permission from ethics committee, a retro prospective study of 1 year duration was undertaken to study the profile of cancer patients and to compare it with other cancer registries in India. Statistical Analysis: Pearson′s Chi-square test and simple linear regression were used. Statistical Package for the Social Sciences version-16 (University of Bristol information services (www.bristol.ac.uk/is/learning/resources was used. RESULTS: The overall incidence of cancer in Kashmir is on the increase and common sites of cancer are esophagus and gastroesophageal (GE junction, lung, stomach, colorectal, lymphomas, skin, laryngopharynx, acute leukemias, prostate and brain in males.In females common sites are breast, esophagus and GE junction, ovary, colorectal, stomach, lung, gallbladder, lymphomas, acute leukemias and brain. Conclusion: Cancers of esophagus, stomach and lungs have a high incidence both in men and women in Kashmir. Future studies on sources and types of environmental pollution and exposures in relation to these cancers may improve our understanding of risk factors held responsible for causation of these malignancies in this region. This will help in the allocation of available resources for prevention and treatment strategies.

  18. Design of magnetic septum of CSR

    International Nuclear Information System (INIS)

    In order to satisfy the requirement of beam injection and extraction of CSR, four magnetic septum will be used in the accelerator. In the design, the shape of the lamination is optimized by 2-D magnetic field calculation. Also, in order to decrease the leakage field and obtain a satisfied field distribution, a special auxiliary coil and a shield iron plate are considered and as well as the construction of the septum leg is treated in a special way. As a result, the leakage field is almost zero and the inhomogeneity is less than 0.1% even in the area very near to the septum leg

  19. Design of Bump Magnet of CSR

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Four bumpers are required for the injection and extraction of CSR. The parameters of the bumpers are shown in table 1. Because of the steep raising and falling time and therefore the inductance of the magnet should be as small as possible, so the material of the magnet cores must be ferrite. And in order to reduce the cost of the bump magnet, the cross-section of the four ferrite cores was designed as the same, as shown in Fig.1.It is very similar to the lamination of the H-type dipole. And Fig.2 is the...

  20. Measurements of indoor radon concentration with CSR detectors

    International Nuclear Information System (INIS)

    The measurements of indoor radon concentration in representative dwellings in Shenyang City were made by CSR detectors, and the results were compared with those obtained by the grab sampling technique. It was shown that the results of the latter were 15%-50% less, and CSR detectors were more suitable for the environment radon investigation

  1. A draft of a business model based on CSR

    OpenAIRE

    Flak, Olaf; Pyszka, Adrian

    2011-01-01

    CSR is a new trend in doing business. Therefore the main goal of this article was to prove that social entrepreneurship and activities in Corporate Social Responsibility provide a new way for creating innovative strategies inside and outside organization (close and open innovations). This is a new innovative CSR-driven business model going beyond traditional management and economic thinking.

  2. Consumer perceptions of CSR: (how) is China different?

    NARCIS (Netherlands)

    A. Kolk; W. van Dolen; L. Ma

    2015-01-01

    Purpose Most studies on consumers and corporate social responsibility (CSR) have focused on Western contexts. Consequently, good insight is lacking into non-Western markets where consumers may respond differently. China is a case in point, despite the popularity of the CSR concept and high societal

  3. Determinants of voluntary CSR disclosure: Empirical evidence from Germany

    NARCIS (Netherlands)

    R. Gamerschlag (Ramin); K. Möller (Klaus); F.H.M. Verbeeten (Frank)

    2011-01-01

    textabstractCurrently, companies spend a great deal of effort on Corporate Social Responsibility (CSR) disclosures. CSR disclosure relates to the provision of information on companies' environmental and social performance. From an economic perspective, companies might disclose this information to av

  4. Individual firm and market dynamics of CSR activities

    NARCIS (Netherlands)

    Wirl, F.; Feichtinger, G.; Kort, P.M.

    2013-01-01

    This paper investigates how firms should plan corporate social responsibility (short CSR). This dynamic analysis starts with a firm's intertemporal optimization problem, and proceeds to analyze interactions with other firms, which are crucial: if CSR is profitable for firm A then it is most likely a

  5. THE GENDER DIFFERENCES EFFECTS ON CORPORATE SOCIAL RESPONSIBILITY (CSR

    Directory of Open Access Journals (Sweden)

    LILIANA NICOLETA SIMIONESCU

    2015-07-01

    Full Text Available Corporate Social Responsibility (CSR refers to company's activities through which they need to contribute to the society well-being. Companies which are socially responsible operate their business in such way stakeholders requirements are a meet as well as ethical, legal, economical and philanthropic expectations toward the society where companies operates. Moreover, businesses decisions and strategies should take into consideration and should act with more responsibility to shareholders, customers, employees, and suppliers. Company's responsibility is more than just legal and economic responsibility. Companies including CSR into their business strategies increase their competitiveness alongside other benefits. Regardless of the heated debates which have been taking place between academics, researchers, scholars, and corporate executives, CSR concept remains open to a range of definitions As well as understanding. This paper aim is to theoretically investigate how differences in gender effect on corporate social responsibility activities with impact on companies’ performance in developing countries. In order to achieve the paper aim, following the literature on CSR and research background, comprehensive research framework was developed. Despite the fact that CSR have been debated on many topics, the gender differences effects on CSR in developing countries is scarce. To fill in this gap, this paper developed a conceptual research framework that enhance the literature on CSR as regard the differences linking male and female’s orientation toward CSR activities.

  6. Consumers’ responses to CSR in a cross-cultural setting

    Directory of Open Access Journals (Sweden)

    Hakan Karaosman

    2015-12-01

    Full Text Available The paper aims to clarify the relationship between corporate social responsibility (CSR and consumer behaviour in an international setting. Consumers’ responses to CSR activities and the impact on the purchase decision are limited discourses. CSR-based studies in the fashion and apparel industry are also scarce. Therefore, this study attempts to enlighten the subject of how consumers from different countries respond to CSR adopted in the fashion and apparel industry. This study is based on an exploratory qualitative research for which focus group interviews, including six group discussions with Spanish and Turkish consumers, have been used. The fundamental dimension for sampling was consumers’ interest and knowledge of CSR-related issues. The data were examined by constant comparison analysis. The paper provides empirical insights that suggest that these consumers, regardless of their country of origin, perceive CSR actions as part of companies’ marketing strategies, while overall consumer awareness to CSR is low. Moreover, the criteria, which determine the purchase decision is to be governed by self-interest. A difference between participants from both countries has been found with regard to their demand for more regulation towards CSR. An identified research need in international marketing discipline, is fulfilled in this study.

  7. 5 CFR 847.503 - Transfers from the CSR Fund.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Transfers from the CSR Fund. 847.503 Section 847.503 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE... from the CSR Fund. For elections of NAFI retirement system coverage under § 847.441, the amount...

  8. 5 CFR 847.502 - Transfers to the CSR Fund.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Transfers to the CSR Fund. 847.502 Section 847.502 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE... to the CSR Fund. For elections of CSRS or FERS coverage under § 847.411 or FERS coverage and...

  9. Analysis of National and EU Policies Supporting CSR and Impact

    DEFF Research Database (Denmark)

    Moon, Jeremy; Slager, Rieneke; Anastasiadis, Stephanos;

    The purpose of this report is to provide an overview of the place of governmental policies in encouraging and supporting Corporate Social Responsibility (CSR) and their effectiveness therein. By: Moon, Jeremy - Slager, Rieneke - Brunn, Christoph - Hardi, Peter - Steen Knudsen, Jette - 2012 The very...... thought of a relationship between CSR and government policies would, from some perspectives, seem counter-intuitive or simply wrong. From these perspectives it would appear to be a category error that a concept founded on voluntarism, vs CSR, should be shaped by the antithesis of voluntarism, vs public...... policy. What the report finds however is that in general terms there has been a remarkable growth of public policies for CSR in Europe. This finding is confirmed both by review of the relevant literature but also our own pan-European analysis. No longer is CSR mainly implicit in public policies...

  10. A Nordic Perspective of Corporate Social Responsibility (CSR

    Directory of Open Access Journals (Sweden)

    Siri Granum Carson

    2011-05-01

    Full Text Available This introduction points to the divergent factors relevant to the topic of CSR, clearly indicating the need for multidisciplinary and cross-disciplinary approaches to this research area. This is reflected in the way CSR has developed at NTNU. For the past 10 years, there has been a focus on CSR in different ways; in course curricula, research projects, and strategic activities across faculties and department and as the focus area within two of the six overall research strategic areas at NTNU: the Globalization research program and the Maritime research program. Environment and energy are core topics in the programs, hereunder long traditions of collaboration with industry in innovative research projects are found. The science and technology profile, but with close connections with the social sciences and humanities, distinguishes CSR research at NTNU. The research focus on CSR attracts students and support possibilities for increased collaboration with industry.

  11. Future atomic physics researches at HIRFL-CSR

    International Nuclear Information System (INIS)

    A new storage ring system, HIRFL-CSR, is now in construction in the National Laboratory of Heavy Ion Research Facility of Lanzhou, China. The new facility consists of a main ring (CSRm) and an experimental ring (CSRe). With the flexibility of the production and the investigation of highly charged ions and radioactive ion beams the new HIRFL-CSR facility will make many frontier atomic physics researches possible in near future. The future physics researches at the HIRFL-CSR are now under consideration. In this paper an overview of the HIRFL-CSR project is given, and the main atomic physics programs to be carried at the HIRFL-CSR are presented. (orig.)

  12. CSR BENEFITS AND COSTS IN A STRATEGIC APPROACH

    Directory of Open Access Journals (Sweden)

    Diana Corina Gligor – Cimpoieru

    2015-09-01

    Full Text Available In recent decades corporate social responsibility (CSR has captured the interest of both practitioners and academics, being a concept extensively analyzed and discussed in terms of its many facets. But maybe due its complexity, still lacking a unified approach and a widely accepted definition, CSR is still often seen as having a peripheral role, auxiliary for a business organization, without even understanding its essence and having overlooked its extraordinary potential to determine multiple bivalent benefits for companies and local communities. Even if CSR benefits are identified, the analysis is often limited to an optimistic view, lacking a realistic approach that recognizes and takes into account also the costs and risks associated. With this paper we aim at identifying the most significant CSR benefits and costs in an attempt to offer a realistic pledging for the importance of CSR implementation in a strategic approach.

  13. CSR BALANCED SCORECARD SYSTEMS AND BUSINESS PERFORMANCES: SMEs CASE STUDY

    Directory of Open Access Journals (Sweden)

    Edward Sek Khin Wong

    2016-01-01

    Full Text Available This paper aims to examine the performance measurement using the CSR Balanced Scorecard system in SMEs firms in Malaysia. It investigates the relationships of the four perspectives of CSR Balanced Scorecard system toward performance measurement. The purpose of this paper is to in- vestigate whether or not the improvement of the non-financial CSR measures will lead to the im- provement of performance measures. To test these relationships, data were collected using the four perspectives approach introduced by Utting (2007. The finding indicates that the organizational business performance can be greatly increased by putting greater emphasis to CSR measures. The results also reveal that the increases of firms customer’s satisfaction is caused by the increase imple- mentation of CSR measurement. At the end of the article, the implications of this study for SME industries and some suggestions are discussed for future studies.

  14. Bioinformatics Study of Cancer-Related Mutations within p53 Phosphorylation Site Motifs

    Directory of Open Access Journals (Sweden)

    Xiaona Ji

    2014-07-01

    Full Text Available p53 protein has about thirty phosphorylation sites located at the N- and C-termini and in the core domain. The phosphorylation sites are relatively less mutated than other residues in p53. To understand why and how p53 phosphorylation sites are rarely mutated in human cancer, using a bioinformatics approaches, we examined the phosphorylation site and its nearby flanking residues, focusing on the consensus phosphorylation motif pattern, amino-acid correlations within the phosphorylation motifs, the propensity of structural disorder of the phosphorylation motifs, and cancer mutations observed within the phosphorylation motifs. Many p53 phosphorylation sites are targets for several kinases. The phosphorylation sites match 17 consensus sequence motifs out of the 29 classified. In addition to proline, which is common in kinase specificity-determining sites, we found high propensity of acidic residues to be adjacent to phosphorylation sites. Analysis of human cancer mutations in the phosphorylation motifs revealed that motifs with adjacent acidic residues generally have fewer mutations, in contrast to phosphorylation sites near proline residues. p53 phosphorylation motifs are mostly disordered. However, human cancer mutations within phosphorylation motifs tend to decrease the disorder propensity. Our results suggest that combination of acidic residues Asp and Glu with phosphorylation sites provide charge redundancy which may safe guard against loss-of-function mutations, and that the natively disordered nature of p53 phosphorylation motifs may help reduce mutational damage. Our results further suggest that engineering acidic amino acids adjacent to potential phosphorylation sites could be a p53 gene therapy strategy.

  15. The electron target for the CSR

    International Nuclear Information System (INIS)

    An ultralow energy photoelectron cooler for the novel cryogenic electrostatic storage ring CSR is under development. The electron device will serve as a major tool for electron-ion collision studies and for phase space cooling of 20-300 keV (E/Q, charge number Q) ions in velocity matched electron and ion beams. Electrons in energy range from 165 eV (matched to 20 keV protons) down to a fraction of eV (matched to heavy molecules of mass up to 160 A/Q) will be confined by 30-150 Gauss guiding magnetic field in a newly developed configuration. The key points related to ultralow energy cooling operation (maximal gun current at the low energies, minimal longitudinal temperature) have been taken into account and were recently studied by experiments at the TSR e-target. Adiabatic beam transport has been simulated by the TOSCA code. In this talk we present experimental and simulation results as well as the mechanical and cryogenic concept of the CSR electron target

  16. Relationship of oral cancer with age, sex, site distribution and habits.

    Science.gov (United States)

    Patel, Mandakini Mansukh; Pandya, Amrish N

    2004-04-01

    Many studies are carried out regarding age incidence, tobacco smoking and sites of oral cancer, but in Gujarat tobacco chewing in form of Gutkha is more common than smoking and start during preteen years. Tobacco chewing causing chronic inflammation, submucous fibrosis and oral cancer. This study was conducted on 504 patients to find out if there is increasing incidence of oral cancer in lower age group and its relation with sex as well which site was commonly affected. There was statistically significant increase in oral cancer in lower age group, and anatomically anterior part of oral cavity showed involvement in 61.32% of cases. Though males were affected more but female cases were 25%. So tobacco chewing has got detrimental effect on oral cavity. PMID:16295466

  17. Post site metastasis of breast cancer after video-assisted thoracic surgery for pulmonary metastasis of breast cancer: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Park, Mee Hyun; Hwang, Ji Young; Hyun, Su Jeong; Lee, Yul; Woo, Ji Young; Yang, Ik; Hong, Hye Sook; Kim, Han Myun [Dept. of Radiology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul (Korea, Republic of)

    2016-05-15

    We reported a case of port site metastasis in a 57-year-old patient who underwent video-assisted thoracic surgery (VATS) resection of pulmonary metastasis from breast cancer. Port site metastasis after VATS is very rare in patients with breast cancer. However, when suspicious lesions are detected near the port site in patients who have undergone VATS for pulmonary metastasis, port site metastasis should be considered in the differential diagnosis.

  18. Defining, Measuring and Supporting Success: Meeting the Challenges of Comprehensive School Reform Research. CSR Connection.

    Science.gov (United States)

    Appelbaum, Deborah; Schwartzbeck, Terri Duggan

    Many educators believe that comprehensive school reform (CSR) holds real promise for improving schools, as many CSR programs are based in research and have documented success. However, in the past year, there has been increased emphasis on CSR programs' evidence of effectiveness and scrutiny of CSR evaluations' degree of rigor. Questions exist…

  19. Corporate Social Responsibility (CSR) and energy industry; Cororate Social Responsibility (CSR) und Energiewirtschaft

    Energy Technology Data Exchange (ETDEWEB)

    Landhaeusser, Werner (ed.) [Mader GmbH und Co. KG, Leinfelden-Echterdingen (Germany); Hildebrandt, Alexandra

    2016-05-01

    What means Corporate Social Responsibility (CSR) in the energy industry? A rising energy demand with limited natural resources pose utilities, industry and consumers with new challenges. This book follows an interdisciplinary approach and for the first time brings together debates and findings from industry, science, politics, culture and media. Because the energy transition can only succeed if it is comprehensible for the individual and fragmented perspectives and interests are merged. [German] Was bedeutet CSR in der Energiewirtschaft? Ein steigender Energiebedarf bei begrenzten natuerlichen Ressourcen stellt Energieversorger, Industrie und Verbraucher vor immer neue Herausforderungen. Dieses Buch folgt einem interdisziplinaeren Ansatz und fuehrt erstmals Debatten und Erkenntnisse aus Wirtschaft, Wissenschaft, Politik, Kultur und Medien zusammen. Denn die Energiewende kann nur gelingen, wenn sie fuer den Einzelnen fassbar wird und fragmentierte Sichtweisen und Interessenlagen zusammengefuehrt werden.

  20. Establishment of CSR Matter-Element Evaluation Model in Perspective of Low Carbon Economy in China

    OpenAIRE

    Li Furong; Zhang Gang

    2013-01-01

    With the development of CSR concept, more and more enterprises begin to bring CSR into practice. Especially in the era of low-carbon economy develops quickly, CSR practice is going to mature. In order to make a scientific evaluation on CSR and promote the comprehensive development of CSR, this study develop a new CSR evaluation model under requires of low-carbon economy development. This CSR evaluation model combined G1 weighting method with the Matter-Element Model and finally verified by an...

  1. CSR and CSR Reporting: Reporting as a way to create Socially Responsible Business

    Directory of Open Access Journals (Sweden)

    Fabio Andrés Bonilla Sanabria

    2011-12-01

    In this scenario the Reporting of Non-Financial Information is studied as a way to create socially responsible businesses. In addressing the reporting of non-financial information, the article provides a state of affairs regarding reporting and considers specific examples of disclosure of corporate information. The CSR battle has been transferred to the reporting of non-financial information but in this field there are many difficulties unresolved and challenges ahead.

  2. Materiality Analysis for CSR Reporting in Spanish SMEs

    Directory of Open Access Journals (Sweden)

    Elena Escrig-Olmedo

    2012-01-01

    Full Text Available Most corporate social responsibility (CSR standards have not been designedto be implemented in small and medium sized enterprises (SMEs. Giventhat 99% of Spanish companies are SMEs, this study aims to propose aselection of basic CSR material issues that, because of their usefulness andsignificance, should be adapted to Spanish SMEs and their stakeholders.This study provides a CSR model for SMEs that includes the most importantsocial, environmental, and corporate governance issues. This model, whichis based on expert knowledge, is useful for integrating sustainability in themanagement of SMEs and enhancing the management of stakeholders.

  3. The differentiated effects of CSR actions in the service industry

    OpenAIRE

    Casado-Díaz, Ana B.; Nicolau, Juan Luis; Ruiz Moreno, Manuel Felipe; Sellers Rubio, Ricardo

    2014-01-01

    Purpose – The purpose of this study is to attempt to explain why the impact of Corporate Social Responsibility (CSR) initiatives may be different and/or more important in service firms compared to manufacturing firms. CSR is becoming a common strategy, hence its extensive research. Central to it is the analysis of the effect of CSR on a firm’s performance, whose outcome depends on firm-specific and industry-related factors. Design/methodology/approach – The event study methodology is applied ...

  4. Hypernucleus Production at RHIC and HIRFL-CSR Energy

    International Nuclear Information System (INIS)

    We calculated the hypertriton production at RHIC-STAR and HIRFL-CSR acceptance, with a multi-phase transport model (AMPT) and a relativistic transport model (ART), respectively. In specific, we calculated the Strangeness Population Factor S3 = Λ3H/(3He x Λ/p) at different beam energy. Our results from AGS to RHIC energy indicated that the collision system may change from hadronic phase at AGS energies to partonic phase at RHIC energies. Our calculation at HIRFL-CSR energy supports the proposal to measure hypertriton at HIRFL-CSR.

  5. Design of Database System of HIRFL-CSR Beam Line

    International Nuclear Information System (INIS)

    This paper introduces the database design and optimization for the power supply system of Lanzhou Heavy Ion Accelerator CSR (HIRFL-CSR) beam line. Based on HIFEL-CSR main Oracle database system, the interface was designed to read parameters of the power supply while achieving real-time monitoring. A new database system to store the history data of power supplies was established at the same time, and it realized the data exchange between Oracle database system and Access database system. Meanwhile, the interface was designed conveniently for printing and query parameters. (authors)

  6. From CSR to Social Risk Management

    DEFF Research Database (Denmark)

    Taarup Esbensen, Jacob

    2014-01-01

    engagement management systems that is promoted through the standard. The implemented social risk management systems are ineffective because they makes the MNC unable to recognise the value of weak ties and fail to build legitimacy and trust with some of the key stakeholders resulting in the creation of more......When it comes to social risks multinational companies (MNC) within Mining are one of the most exposed businesses one can imagine. This paper examines how social risk management is practiced through the case of Teghout copper-molybdenum mine in North- Eastern Armenia, supplemented with evidence from...... other mining MNCs in the country, onsite fieldwork, interviews with key stakeholders, and public available information. This evidence suggest that a standards based social risk management strategy is adopted and that this strategy is based on international Corporate Social Responsibility (CSR) standards...

  7. Radioactive ion beam line of CSR

    International Nuclear Information System (INIS)

    A new radioactive ion beam line designed to work at higher energy equivalent up to a magnetic rigidity of 10.64 Tm is going to be constructed at Lanzhou. It is to connect the main ring and the experiment ring of the HIRFL-CSR complex. The separator is mirror-symmetrically configured both in geometry and magnet strength, achieving a point-point and parallel-parallel image at its intermediate focal plane with maximum spatial dispersion. Achromatism is automatically realized at the final focal plane. The total length is about 26 meters. Its resolution power of magnetic rigidity is 1200 at +- 1% momentum deviation and +- 25 mrad divergence simultaneously. With sextupole- and octupole- magnets carefully positioned and powered, second and third-order aberrations are corrected to a large extent. The magnet design has already fulfilled

  8. CSR communication to consumers in clothing markets - Mapping consumer interest, awareness, attitudes and expectations

    OpenAIRE

    Kivekäs, Lotta

    2013-01-01

    CSR communication to consumers in clothing markets - Mapping consumer interest, awareness, attitudes and expectations. Objective of the Study The aim of the study was to investigate consumer perceptions of CSR (corporate social responsibility) and CSR communication in order to improve company ability to effectively communicate on CSR. The study was motivated by research indicating low consumer awareness of and trust in CSR. The study focused on the clothing industry as clothing comp...

  9. CSR Communication - An Employee Perspective : Tailoring Internal Communication using Employee Preferences for Content, Style and Channel.

    OpenAIRE

    Jonsson, Viktoria; Linnér, Rebecka

    2016-01-01

    Corporate Social Responsibility (CSR) represents a theory and practice that is well-known and communicating its content has shown to play an important role in order to exploit its advantages and engage stakeholders on CSR issues. Even though, CSR communication has shown to be a real challenge, since corporations are encouraged to engage in CSR, but not to communicate too loud about this engagement. This study was inspired by Jenny Dawkins (2005) and her initial idea that tailoring CSR message...

  10. Analýza CSR aktivit vybrané společnosti

    OpenAIRE

    Kačabová, Petra

    2013-01-01

    The Master thesis deals with a topic of Corporate Social Responsibility. In the theoretical part the CSR concept is explained. The author describes the increasing significance of CSR, its definition, three main pillars, reasons why to implement CSR and its possible crtiticism. Furthermore, it shows indices used for measurement and organizations handling CSR issue. In the practical part, at first, the influnce of CSR on consumers' decision making process and behaviour is demonstrated. The gene...

  11. How Does It Fit? Exploring the Congruence Between Organizations and Their Corporate Social Responsibility (CSR) Activities

    OpenAIRE

    Jong, de, J.; Meer, Van Der, Alex J.

    2015-01-01

    Several studies have focused on the effects of corporate social responsibility (CSR) fit on external stakeholders’ evaluations of CSR activities, attitudes towards companies or brands, and behaviors. The results so far have been contradictory. A possible reason may be that the concept of CSR fit is more complicated than previously assumed. Researchers suggest that there may be different types of CSR fit, but so far no empirical research has focused on a typology of CSR fit. This study fills t...

  12. The Differential Effects of Social Media Sites for Promoting Cancer Risk Reduction.

    Science.gov (United States)

    Lauckner, Carolyn; Whitten, Pamela

    2016-09-01

    Social media are potentially valuable tools for disseminating cancer education messages, but the differential effects of various sites on persuasive outcomes are unknown. In an effort to inform future health promotion, this research tested the effects of Facebook, YouTube, Twitter, and blogs for delivering a cancer risk reduction message. Using an experimental design, participants were randomly placed in several conditions that delivered the same message but with different forms of social media. Effects on comprehension and attitudes were examined, as they are important variables in the behavior change process. YouTube led to higher comprehension and stronger attitudes toward cancer risk reduction than Twitter, but there were no differences between other sites. Additionally, YouTube led to stronger attitudes toward cancer risk reduction as compared to Facebook, but not any other sites. These results demonstrate that, even if the message is kept constant, the form of social media used to deliver content can have an effect on persuasive outcomes. More research is needed to determine the mechanisms behind the differences found, however. Altogether, this line of research is valuable for any individuals seeking to use social media for health promotion purposes and could have direct implications for the development of cancer risk reduction campaigns. PMID:26156568

  13. The Differential Effects of Social Media Sites for Promoting Cancer Risk Reduction.

    Science.gov (United States)

    Lauckner, Carolyn; Whitten, Pamela

    2016-09-01

    Social media are potentially valuable tools for disseminating cancer education messages, but the differential effects of various sites on persuasive outcomes are unknown. In an effort to inform future health promotion, this research tested the effects of Facebook, YouTube, Twitter, and blogs for delivering a cancer risk reduction message. Using an experimental design, participants were randomly placed in several conditions that delivered the same message but with different forms of social media. Effects on comprehension and attitudes were examined, as they are important variables in the behavior change process. YouTube led to higher comprehension and stronger attitudes toward cancer risk reduction than Twitter, but there were no differences between other sites. Additionally, YouTube led to stronger attitudes toward cancer risk reduction as compared to Facebook, but not any other sites. These results demonstrate that, even if the message is kept constant, the form of social media used to deliver content can have an effect on persuasive outcomes. More research is needed to determine the mechanisms behind the differences found, however. Altogether, this line of research is valuable for any individuals seeking to use social media for health promotion purposes and could have direct implications for the development of cancer risk reduction campaigns.

  14. Repeated occurrence of second primary lung cancer at different sites in trachea: a case report.

    Science.gov (United States)

    Lee, Yong Chul; Park, Yun Ji; Gang, Su Jin; Chung, Myung Ja; Kim, So Ri

    2015-05-01

    Multiple or second primary lung cancers can develop at any sites in the lung with same or different histologic types, synchronously and/or metachronously. In case of metachronous occurrence of the second primary lung cancer, it is easy to confuse with the primary lung cancer as a recurrence of precedent lung malignancy treated successfully or metastasis. Previous reports have demonstrated that majority of the second primary lung malignancies have same histologic types regardless of their developing time and location. However, the repeated occurrence of the second primary lung malignancy, in particular with the different histologic features, is a very rare condition.A 62-year-old male who had past history of squamous cell carcinoma treated with surgery and adjuvant chemotherapy and the recurrence of lung malignancy on the trachea, which was also resected successfully visited our hospital due to blood tinged sputum. Evaluation using bronchoscopy and chest computed tomography revealed the tracheal mass looked similar grossly to the previous recurred tracheal mass that was resected surgically. Unexpectedly, the newly developed tracheal mass was confirmed as small cell lung cancer, the different histologic type from previous ones.In this report, we describe an interesting case of subsequent occurrence of second primary lung cancers showing histologic shifting at different sites in trachea, suggesting that it is important for physician to make an effort to identify the histologic characteristics of second primary lung cancers for the correct and adequate treatment no matter what they exhibit similar gross morphology.

  15. ALERT. Adverse late effects of cancer treatment. Vol. 2. Normal tissue specific sites and systems

    Energy Technology Data Exchange (ETDEWEB)

    Rubin, Philip; Constine, Louis S. [Univ. Rochester Medical Center, NY (United States). Dept. of Radiation Oncology; Marks, Lawrence B. (ed.) [Univ. North Carolina and Lineberger, Comprehensive Cancer Center, Chapel Hill, NC (United States). Dept. of Radiation Oncology

    2014-09-01

    Comprehensively documents potential late effects in all the normal tissue sites in the human body. Considers in detail the detection, diagnosis, management and prevention of effects and discusses prognostic outcomes. Clearly presents radiation risk factors and interactions with chemotherapy effects. Provides the most current evidence-based medicine for cancer care survivorship guidelines. The literature on the late effects of cancer treatment is widely scattered in different journals since all major organ systems are affected and management is based on a variety of medical and surgical treatments. The aim of ALERT - Adverse Late Effects of Cancer Treatment is to offer a coherent multidisciplinary approach to the care of cancer survivors. The central paradigm is that cytotoxic multimodal therapy results in a perpetual cascade of events that affects each major organ system differently and is expressed continually over time. Essentially, radiation and chemotherapy are intense biologic modifiers that allow for cancer cure and cancer survivorship but accelerate senescence of normal tissues and increase the incidence of age-related diseases and second malignant tumors. Volume 2 of this two-volume work comprehensively documents potential late effects in all the normal tissue anatomic sites in the human body. The detection, diagnosis, management and prevention of effects are all considered in detail, and prognostic outcomes are discussed. Radiation risk factors and interactions with chemotherapy effects are clearly presented. The text is accompanied by numerous supportive illustrations and tables.

  16. "Identification Card": Sites on Histone Modification of Cancer Cell.

    Science.gov (United States)

    Huang, Chao; Wen, Bin

    2015-12-01

    Formation of malignant tumor originating from normal healthy cell is a multistep process including genetic and epigenetic lesions. Previous studies of cell line model systems displayed that early important epigenetic events happened in stepwise fashion prior to cell immortalization. Once these epigenetic alterations are integrated into chromatin, they will perform vertical propagation through cell subculture. Hence, status of epigenetics is dramatically important in maintaining of cell identity. Histone modification is another factor of epigenetic alterations during human oncogenesis. Histones, one of main components of chromatin, can be modified post-translationally. Histone tail modifications are regulated by corresponding modification enzymes. This review focuses on the description of relationship between the main sites of histone modification and oncogenesis. PMID:26960300

  17. Targeting Alternative Sites on the Androgen Receptor to Treat Castration-Resistant Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Paul S. Rennie

    2013-06-01

    Full Text Available Recurrent, metastatic prostate cancer continues to be a leading cause of cancer-death in men. The androgen receptor (AR is a modular, ligand-inducible transcription factor that regulates the expression of genes that can drive the progression of this disease, and as a consequence, this receptor is a key therapeutic target for controlling prostate cancer. The current drugs designed to directly inhibit the AR are called anti-androgens, and all act by competing with androgens for binding to the androgen/ligand binding site. Unfortunately, with the inevitable progression of the cancer to castration resistance, many of these drugs become ineffective. However, there are numerous other regulatory sites on this protein that have not been exploited therapeutically. The regulation of AR activity involves a cascade of complex interactions with numerous chaperones, co-factors and co-regulatory proteins, leading ultimately to direct binding of AR dimers to specific DNA androgen response elements within the promoter and enhancers of androgen-regulated genes. As part of the family of nuclear receptors, the AR is organized into modular structural and functional domains with specialized roles in facilitating their inter-molecular interactions. These regions of the AR present attractive, yet largely unexploited, drug target sites for reducing or eliminating androgen signaling in prostate cancers. The design of small molecule inhibitors targeting these specific AR domains is only now being realized and is the culmination of decades of work, including crystallographic and biochemistry approaches to map the shape and accessibility of the AR surfaces and cavities. Here, we review the structure of the AR protein and describe recent advancements in inhibiting its activity with small molecules specifically designed to target areas distinct from the receptor’s androgen binding site. It is anticipated that these new classes of anti-AR drugs will provide an additional

  18. Cancer and birth defects surveillance system for communities around the Savannah River Site

    Energy Technology Data Exchange (ETDEWEB)

    Dunbar, J.B.

    1993-05-01

    This technical report presents the age-adjusted total, and race and sex specific geographic patterns of cancer mortality for South Carolina (SC) counties utilizing the 1953--1987 average annual age-adjusted mortality rates (AAMRs). The mortality information was obtained from the State Cancer Control Map and Data Program produced by the National Cancer Institute , Centers for Disease Control and the American Cancer Society. The AAMRs for selected primary sites are classified as significantly different or not significantly different from the corresponding United States and SC mortality rates. Categories for classification of the rates are determined using 95% confidence intervals. Geographic patterns of significantly high county AAMRs are identified and discussed. Individual county rates are not emphasized. The terminology, mortality rates used throughout this report pertains to the 1953--1987 AAMRS.

  19. Cancer and birth defects surveillance system for communities around the Savannah River Site. Annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Dunbar, J.B.

    1993-05-01

    This technical report presents the age-adjusted total, and race and sex specific geographic patterns of cancer mortality for South Carolina (SC) counties utilizing the 1953--1987 average annual age-adjusted mortality rates (AAMRs). The mortality information was obtained from the State Cancer Control Map and Data Program produced by the National Cancer Institute , Centers for Disease Control and the American Cancer Society. The AAMRs for selected primary sites are classified as significantly different or not significantly different from the corresponding United States and SC mortality rates. Categories for classification of the rates are determined using 95% confidence intervals. Geographic patterns of significantly high county AAMRs are identified and discussed. Individual county rates are not emphasized. The terminology, mortality rates used throughout this report pertains to the 1953--1987 AAMRS.

  20. Accuracy of Self-Reported Breast Cancer Information among Women from the Ontario Site of the Breast Cancer Family Registry

    Directory of Open Access Journals (Sweden)

    Andriana Barisic

    2012-01-01

    Full Text Available Obtaining complete medical record information can be challenging and expensive in breast cancer studies. The current literature is limited with respect to the accuracy of self-report and factors that may influence this. We assessed the agreement between self-reported and medical record breast cancer information among women from the Ontario site of the Breast Cancer Family Registry. Women aged 20–69 years diagnosed with incident breast cancer 1996–1998 were identified from the Ontario Cancer Registry, sampled on age and family history. We calculated kappa statistics, proportion correct, sensitivity, specificity, and positive and negative predictive values and conducted unconditional logistic regression to examine whether characteristics of the women influenced agreement. The proportions of women who correctly reported having received a broad category of therapy (hormone therapy, chemotherapy, radiation, or surgery as well as sensitivity and specificity were above 90%, and the kappa statistics were above 0.80. The specific type of hormonal or chemotherapy was reported with low-to-moderate agreement. Aside from recurrence, no factors were consistently associated with agreement. Thus, most women were able to accurately report broad categories of treatment but not necessarily specific treatment types. The finding of this study can aid researchers in the use and design of self-administered treatment questionnaires.

  1. Corporate Social Responsibility (CSR in India: A Review

    Directory of Open Access Journals (Sweden)

    Neelmani Jaysawal

    2015-11-01

    Full Text Available Corporate Social Responsibility (CSR is a concept, which states that Private Corporation or public organization has a responsibility to society. It minimizes the cost as well as risks thereby, increasing the brand value and reputation of the company. According to Bowen, “CSR refers to the obligations of businessmen to pursue those policies to make those decisions or to follow those lines of relations which are desirable in terms of the objectives and values of our society.” The CSR activities need to be in tune with effective strategic policies so that the aim of sustainable environmental, social and economic progress may be achieved. Methodology: This paper is based on qualitative research design consisting of review of literature through secondary sources of data collection. The data has been examined through content analysis process from various books, newspaper articles and journals. This paper seeks to explain various initiatives taken in the field of CSR along with some key challenges.

  2. Lönsamhet med CSR hosMAX Hamburgare

    OpenAIRE

    Nisell, Samuel; Kaya, Roni

    2012-01-01

    När företag engagerar sig i CSR-frågor främjar det miljö och samhälle. Denna rapport utreder hur CSR-arbetet också kan gynna företaget ur ett ekonomiskt perspektiv. Rapporten behandlar hamburgerkedjan Max Hamburgares hållbarhetssatsning och besvarar frågorna: • Är Max Hamburgares CSR-arbete ekonomiskt lönsamt för dem själva? • Är någon/några av Max Hamburgares CSR-åtgärder förlust- respektive vinstaffärer? För att besvara frågorna har en omfattande studie kring ämnet och företaget genomförts ...

  3. THE RELATIONSHIP BETWEEN MODELS OF QUALITY MANAGEMENT AND CSR

    Directory of Open Access Journals (Sweden)

    CĂTĂLINA SITNIKOV

    2015-03-01

    Full Text Available Lately, the quality management has integrated more and more among its components Corporate Social Responsibility (CSR. With strong roots in the foundation for sustainable development, protection of the environment, issues of social justness and economic growth, CSR raises numerous issues related to obtaining profits, business performance and firms and activities based on the quality of management. From the point of view of the last issues, the models of quality management built on the fundamental principles of quality become the foundation and catalyst for the effective implementation of CSR in organizations. This is the reason why it is necessary to investigate the extent to which quality management models provide frameworks and guidelines for integrating CSR in the management of quality and, moreover, in the management of the organization, with a clear focus on the extent to which the concept can be institutionalized and operated by the organization.

  4. Self-consistent simulation of the CSR effect

    International Nuclear Information System (INIS)

    When a microbunch with high charge traverses a curved trajectory, the curvature-induced bunch self-interaction, by way of coherent synchrotron radiation (CSR) and space-charge forces, may cause serious emittance degradation. In this paper, the authors present a self-consistent simulation for the study of the impact of CSR on beam optics. The dynamics of the bunch under the influence of the CSR forces is simulated using macroparticles, where the CSR force in turn depends on the history of bunch dynamics in accordance with causality. The simulation is benchmarked with analytical results obtained for a rigid-line bunch. Here they present the algorithm used in the simulation, along with the simulation results obtained for bending systems in the Jefferson Lab (JLab) free-electron-laser (FEL) lattice

  5. CSR routine for low energy electron beam in GPT

    International Nuclear Information System (INIS)

    General Particle Tracer (GPT) is a particle tracking code, which includes 3D space charge effect based on nonequidistant multigrid Poisson solver or point-to-point method. It is used to investigate beam dynamics in ERL and FEL injectors. We have developed a new routine to simulate coherent synchrotron radiation (CSR) in GPT based on the formalism of Sagan. The routine can calculate 1D-wake functions for arbitrary beam trajectories as well as CSR shielding effect. In particular, the CSR routine does not assume ultrarelativistic electron beam and is therefore applicable at low beam energies in the injector. Energy loss and energy spread caused by CSR effect were checked for a simple circular orbit, and compared with analytic formulas. (author)

  6. CSR jako przedsięwzięcie biznesowe

    OpenAIRE

    Szymon Wierciński

    2011-01-01

    Niniejszy artykuł poświęcony jest relacji między programami społecznej odpowiedzialności biznesu a wynikami finansowymi organizacji (CSR – CFP). Podążając za nurtem badaczy poszukujących biznesowego uzasadnienia dla CSR, autor przedstawia problemy i wyzwania stojące przed menedżerami i naukowcami, dotyczące mierzenia efektywności programów CSR. Przegląd literatury prowadzi do zwrócenia szczególnej uwagi na problem związany z precyzyjnym mierzeniem wpływu CSR na różnych poziomach organizacji i...

  7. CSR, Employee Job Attitude and Behavior: Saudi Bank Experience

    Directory of Open Access Journals (Sweden)

    Mohammad Tahlil AZIM

    2014-11-01

    Full Text Available The present study explores the relation- ship between the external CSR practices of the organizations and employees’ job satisfaction, employee engagement and organizational cit- izenship behavior in the context of the Saudi banking industry. A positive relationship between CSR and employee job satisfaction, employee engagement and organizational citizenship be- havior related to the organization is observed. However, the organizational citizenship behavior related to individual is found unrelated to CSR. The theoretical foundation of the study is ground- ed in the spirit of social identity theory (Tajfel and Turner, 1979 and social exchange theory (Blau, 1964. The study implies that involvement in ex- ternal CSR may be a determinant for maintaining a motivated and enthusiastic workforce. 

  8. Should CSR Be Ignored Due to the Economic Crisis?

    Institute of Scientific and Technical Information of China (English)

    Guo Yan

    2009-01-01

    @@ Due to the economic crisis,many companies are struggling for a living.So,should the Corporate Social Responsibilitv(CSR)be put aside before these companies can secure their survival?Of course the answer is no.

  9. CSR-induced emittance growth in achromats: Linear formalism revisited

    Energy Technology Data Exchange (ETDEWEB)

    Venturini, M.

    2015-09-11

    We review the R-matrix formalism used to describe Coherent Synchrotron Radiation (CSR)-induced projected emittance growth in electron beam transport lines and establish the connection with a description in terms of the dispersion-invariant function.

  10. CSR and the Mediated Emergence of Strategic Ambiguity

    DEFF Research Database (Denmark)

    Guthey, Eric; Morsing, Mette

    2014-01-01

    We develop a framework for understanding how lack of clarity in business press coverage of corporate social responsibility functions as a mediated and emergent form of strategic ambiguity. Many stakeholders expect CSR to exhibit clarity, consistency, and discursive closure. But stakeholders also...... expect CSR to conform to varying degrees of both formal and substantive rationality. These diverse expectations conflict with each other and change over time. A content analysis of press coverage in Denmark suggests that the business media reflect and amplify the ambiguity generated by these shifting...... demands. We propose that this very public lack of discursive closure provides strategic advantages to CSR stakeholders by rendering the concept of CSR adaptable, resilient, and meaningful to diverse interests. From this perspective, strategic ambiguity emerges from a relational and mediated process...

  11. CSR-induced emittance growth in achromats: Linear formalism revisited

    Science.gov (United States)

    Venturini, M.

    2015-09-01

    We review the R-matrix formalism used to describe Coherent Synchrotron Radiation (CSR)-induced projected emittance growth in electron beam transport lines and establish the connection with a description in terms of the dispersion-invariant function.

  12. Does CSR Create Value for Companies In Malaysia? An Empirical Study of Effect of CSR towards Financial Performance on Shariah and Non Shariah-Compliant Companies in Malaysia

    OpenAIRE

    Ding, Huey Chyi

    2015-01-01

    Over the years, there has been a significant rise in the awareness and practice of Corporate Social Responsibility (CSR) globally. Studies covered various dimensions of CSR have been carried out extensively in developed countries, with results varied that CSR active companies outperformed their peers in term of financial returns, others shown no significant correlations while some concluded that CSR activities do not pay. Similar trend of research gained distinctive attention from the develop...

  13. Creating shared value through strategic CSR in tourism

    OpenAIRE

    Camilleri, Mark Anthony

    2012-01-01

    Literature review about corporate social responsibility (CSR) suggests that there are organisational benefits to be gained from unintentional discretionary expenditure in laudable behaviour. With this in mind, the methodology integrates insights from the ‘stakeholder theory’ and the ‘resource-based view theory of the firm’ to sharpen the strategic base for CSR investment. Quantitative and qualitative research techniques have been used to discover how business organisations a...

  14. THE RELATIONSHIP BETWEEN MODELS OF QUALITY MANAGEMENT AND CSR

    OpenAIRE

    CĂTĂLINA SITNIKOV; CLAUDIU BOCEAN

    2015-01-01

    Lately, the quality management has integrated more and more among its components Corporate Social Responsibility (CSR). With strong roots in the foundation for sustainable development, protection of the environment, issues of social justness and economic growth, CSR raises numerous issues related to obtaining profits, business performance and firms and activities based on the quality of management. From the point of view of the last issues, the models of quality management built o...

  15. Communicating CSR: practices among Switzerland's top 300 companies

    OpenAIRE

    Birth, Gregory; Illia, Laura; Lurati, Fransceso; Zamparini, Alessandra

    2011-01-01

    Purpose – The purpose of this paper is to provide a picture of the practice of corporate social responsibility (CSR) communication among the top 300 companies in Switzerland and to investigate how favorable the cultural context is for this kind of communication. Design/methodology/approach – The investigation of the top 300 companies in Switzerland was conducted using a written survey that built on previous studies. Findings – CSR communication in Switzerland appears to be well developed, b...

  16. Communicating CSR and Brand Personality through Social Media

    OpenAIRE

    Lopez, Cecilia Maria

    2015-01-01

    In the competitive atmosphere of today's business world, corporate social responsibility (CSR) has become yet another factor organizations use to distinguish themselves and make their values apparent to their audiences. Social media have helped organizations communicate these characteristics with their audiences by enabling timely and cost-effective communication between individuals and organizations. While many studies have explored the role of social media in communicating CSR messages, few...

  17. Application of CSR Programs in the Airline Industry

    OpenAIRE

    Anttila, Timo; Kretzschmar, Annika

    2010-01-01

    The subject of this thesis was to analyze the global airline business environment and corporate social responsibility (CSR) program implementations of some well-known airlines. The research has been conducted with the assumption that corporate social responsibility theory is valid. Our purpose was to give the reader and overall impression of airline industry in general, CSR theory and its most important elements. The work is divided into two distinct parts; theory and practical analysis o...

  18. Impact on the magnetic compressor due to CSR

    International Nuclear Information System (INIS)

    When an electron bunch is compressed in a chicane compressor, the CSR (coherent synchrotron radiation) will induce energy redistribution along the bunch. Such energy redistribution will affect the longitudinal emittance as a direct consequence. It will also excite betatron oscillation due to the chromatic transfer functions, and hence a transverse emittance change. So, it is indispensable for us to find a way to alleviate the CSR-caused emittance dilution and the bad result of chicane compressor in PKU-FEL. (authors)

  19. Developing Corporate Strategic Framework to Enhance Sustainability through CSR

    OpenAIRE

    Sapovadia, Vrajlal

    2015-01-01

    CSR activities as applicable under the new company law in India may be used as sustainability strategy by the business. In order to comply with the mandate and with a positive mind set to augment implied benefits thereof, author investigates selected business scenarios to find an optimal pattern of CSR activities that may have long term beneficial impact to the critical stakeholders. This strategic framework propose sustainability model over triple bottom line by addressing holistic issues in...

  20. Corporate-NGO partnerships in CSR activities: why and how?

    OpenAIRE

    Poret, Sylvaine

    2014-01-01

    This article describes, analyzes, and explains the emergence of partnerships between corporations and non-governmental organizations (NGOs) and the ways in which corporations use such relationships as part of their corporate social responsibility (CSR) activities. Economics concepts and the management literature are reviewed, and illustrations are provided to describe such alliances and to explain their expansion. The findings show that firms engage in CSR for altruistic, defensive, and strat...

  1. The effect of culture on businesses' perception of CSR

    OpenAIRE

    Dufays, Frédéric

    2005-01-01

    Numerous interpretations regarding the content, the form, and the rationale for CSR co-exist despite the publication of international codes of conduct such as the U.N. Global Compact. The variety in perceptions of CSR can be explained by a number of factors: individual characteristics such as gender, age, and personal values; organisational characteristics such as firm size and organisational culture; and environmental factors such as industry and national institutions. The latter factor l...

  2. Corporate Social Responsibility (CSR) on Metallurgy Sector in Greece

    OpenAIRE

    Metaxas, Theodore; Tsavdaridou, Maria

    2012-01-01

    Corporate Social Responsibility (CSR) has become one of the most widespread business topics among the academic community. Various issues like environmental pollution, economic crisis, corruption, poverty are of major importance these days and besides governments and politicians’ responsibility it is obvious that corporations are also part of these problems. In Europe the last 15 years, governments, NGOs, small and large enterprises are making an effort to establish in their business CSR strat...

  3. CSR ve vybrané společnosti

    OpenAIRE

    Jakubcová, Lenka

    2013-01-01

    The theme of this thesis is the Corporate Social Responsibility. The theoretical part deals with the basic concepts and principles connected with CSR, its history, Triple Bottom Line structure and the stakeholder analysis. It also describes the available methods for measuring social responsibility and the prizes awarded for the most responsible companies. Finally, it also presents the attitudes of Czech firms and Czech public towards CSR and summarizes the main arguments for and against the c...

  4. CSR, Employee Job Attitude and Behavior: Saudi Bank Experience

    OpenAIRE

    Mohammad Tahlil AZIM; Abdulhamid A. DIYAB; Saleh A. AL-SABAAN

    2014-01-01

    The present study explores the relation- ship between the external CSR practices of the organizations and employees’ job satisfaction, employee engagement and organizational cit- izenship behavior in the context of the Saudi banking industry. A positive relationship between CSR and employee job satisfaction, employee engagement and organizational citizenship be- havior related to the organization is observed. However, the organizational citizenship behavior related to individual is found unre...

  5. Corporate Social Responsibility (CSR): A Scale Development Study in Iran

    OpenAIRE

    Kambiz Heidarzadeh Hanzaee; Amanolla Rahpeima

    2013-01-01

    The present research aims to explore a scale of Corporate Social Responsibility (CSR) in Iran. In this way, it reviews the literature exist on corporate social responsibility, gathers data and analyzes the data to test the emerging trends. After confirmation of reliability, factor analysis and multi dimensional scaling are used to an established survey instrument. Finally CSR was achieved as a construct with five dimensions: obligation to employees, obligation to customers and markets, obliga...

  6. CSR in investor relations: Socially responsible investors and shareholder engagement

    OpenAIRE

    Lipponen, Essi

    2013-01-01

    Abstract OBJECTIVES Shareholders and investors have generally been considered to be stakeholders with limited interest in corporate social responsibility. This trend is changing, as today many investors perceive CSR as a factor that has implications on the bottom line. The main purpose of this study was to examine how CSR is present in investor relations (IR). The focus was on the interaction between socially responsible investors (SRIs) and IR as well as on shareholder engagement. In t...

  7. Strategic CSR Assets within SMEs: A Comparative Case Study

    OpenAIRE

    Elise Bonneveux; Isabelle Calmé; Richard Soparnot

    2012-01-01

    This article aims to show the extent to which strategic organizational resources and assets may determine the type of CSR strategy deployed in SMEs. It is based on the Resource Based View (RBV) approach that allows the authors to propose a theoretical grid to analyse CSR commitment considering the assets mobilized. We have conducted interviews with two SME chief executives with a view to assessing their perception of both internal and external challenges involved in corporate responsibility p...

  8. THE ROLE OF INTERACTIVE TECHNOLOGIES FOR CSR COMMUNICATION

    OpenAIRE

    Gianpaolo Tomaselli; Monia Melia

    2014-01-01

    This work aims to investigate the roles of new interactive technologies to communicate Corporate Social Responsibility (CSR). We adopt the case study method and examine three companies that have successfully approached and developed CSR communication campaigns during the last few years. The study shows how companies use interactive technologies, website and traditional communication channels in integrative ways. Interactive technologies allow more interaction, dialogue and experience sharing....

  9. ISO 26000 som et virkemiddel for institusjonalisering av samfunnsansvar (CSR)

    OpenAIRE

    Ditlev-Simonsen, Caroline D.

    2011-01-01

    Det eksisterer diverse frivillige standarder og verktøy knyttet til bedrifters samfunnsansvar (CSR). Et nytt «skudd på stammen » er ISO 26000 Veiledning om samfunnsansvar. Denne standarden, som er utarbeidet av 500 eksperter fra 40 land, ble lansert i desember 2010. Denne artikkelen presenterer ISO 26000 og vurderer effekten av de viktigste foregående internasjonale standardene og veilederne innen CSR-in...

  10. Multi-channel temperature measurement system for CSR

    International Nuclear Information System (INIS)

    The thesis introduces a multi-channel (64) monitor system of temperature which serves magnetic field safety in CSR. According to the needs of CSR project, the system whose attainable precision is ±1 degree C is able to measure temperature of a few hundred points on magnet windings. This instrument was based on Msp430F149. The research, design and implementation of its hardware and software are particularly described in this thesis. (authors)

  11. Heritage tourism, CSR and the role of employee environmental behaviour.

    OpenAIRE

    Wells, V.; Manika, D.; Gregory-Smith, D.; B. Taheri; McCowlen, C.

    2015-01-01

    Although research on corporate social responsibility (CSR) has grown steadily, little research has focused on CSR at the individual employee level within cultural heritage tourism. This article sheds light on the antecedents of employee environmental behaviour and the effects of a social marketing intervention in a tourism organisation using a mixed methods longitudinal approach. Qualitative results (from 68 respondents) suggest knowledge and awareness of environmental solutions are often lac...

  12. Kommunikationen bag CSR i Novo Nordisk A/S

    OpenAIRE

    Møller, Petra Victoria Akullu; Nygaard, Mette Skytte; Larsen, Kathrine Espander; Eriksen, Rie Christine Søgaard; Bærnholdt, Alexandra Amann

    2016-01-01

    This paper examines how Novo Nordisk disseminates Corporate Social Responsibility (CSR) strategies through selected parts of Novo Nordisk Annual Report 2014. These processes are analyzed with reference to: Louise Phillips’ dialogic communication theory and how it is executed in accordance with Michael E. Porter and Mark R. Kramer’s CSR strategies and R. Edward Freeman’s stakeholder theory. To reinforce these theories a semi-structured interview with the managing director of communication at N...

  13. A Foucauldian investigation of CSR and the concept of responsibility

    OpenAIRE

    Engel, Cecile

    2015-01-01

    Purpose – The dissertation aims to highlight a potential new intellection of CSR – and especially of the concept of responsibility – from CMS theoretical perspectives and Foucault’s theories of sovereignty and governmentality. Design/methodology/approach – The reinterpretation proposed in this paper is based on the denaturalization and subsequent theorization of CSR as an expression of the new spirit of capitalism. The author connects Foucauldian notions of sovereignty and governmentality...

  14. Strategic use of CSR as a signal for good management

    OpenAIRE

    LUIS GOMEZ - MEJIA

    2008-01-01

    More than thirty years of research exploring the link between corporate social responsibility (CSR) and corporate financial performance (CFP) could not provide a satisfying resolution to the tension exists between economic and social objectives. In this paper, we have contributed to the existing CSR literature both theoretically and empirically. On the theoretical side, we challenged the assumption that managers consider all stakeholders equally important and we contend that managers prioriti...

  15. Effect of CSR shielding in the compact linear collider

    CERN Document Server

    Esberg, J; Apsimon, R; Schulte, D

    2014-01-01

    The Drive Beam complex of the Compact Linear Collider must use short bunches with a large charge making beam transport susceptible to unwanted effects of Coherent Synchrotron Radiation emitted in the dipole magnets. We present the effects of transporting the beam within a limited aperture which decreases the magnitude of the CSR wake. The effect, known as CSR shielding, eases the design of key components of the facility.

  16. Praktyka wdrażania CSR w polskich przedsiębiorstwach w opinii doradców

    OpenAIRE

    Rogowski, Robert

    2016-01-01

    The paper presents the experiences of advisers in implementing the concept of CSR in Polish enterprises. The article presents the results of surveys covering such issues as the implementation of CSR motives and actions taken by operators in the implementation of CSR policies. CSR advisors also identified that companies can use unethical practices. This is also a characteristic of CSR advisors.

  17. THE CORPORATE CONSTITUTIONALISM APPROACH IN FORMULATION OF CSR

    Directory of Open Access Journals (Sweden)

    Victor Imanuel Nalle

    2015-04-01

    Full Text Available The 21st century is the era of the development of corporate social responsibility (CSR. It is encouraged by the development of the company as a business and societal entities that balances public and private interests. If there is a balance of public and private interests in the company, the application of CSR should be able to accommodate the public interest. But many companies in Indonesia do not involve the community in the formulation of CSR implementation model. This resulted in the implementation of CSR is often not well targeted. In that context, the theory of corporate constitutionalism becomes relevant theory to answer these problems. The theory of corporate constitutionalism put deliberation as one of the principles to achieve the legitimacy of decision-making in the corporation. Through a process of deliberation formulation of CSR model with the community, not just the interests of shareholders that can be accommodated but also the interests of stakeholders. Thus, CSR can actually be instrumental in the global and local challenges.

  18. CSR Maturity and Motivation in the Water Sector

    DEFF Research Database (Denmark)

    Lauesen, Linne Marie

    2016-01-01

    Purpose: - This paper aims to examine the literature of CSR motivation and presents research results from a case study of the water sector (water companies from Denmark, the UK, the USA and South Africa) and its motivation for and maturity in its CSR work. Design/methodology/approach - The method......Purpose: - This paper aims to examine the literature of CSR motivation and presents research results from a case study of the water sector (water companies from Denmark, the UK, the USA and South Africa) and its motivation for and maturity in its CSR work. Design......-mature according to the proposed CSR Maturity Framework, because it has only reached the level of CSR reporting, but neither suggests definitions of sustainability nor shows any particularly good transparency and accountability yet. Research limitations/implications: - The research is limited to water companies....../methodology/approach - The methodology used in this paper is first a literature review followed by research done with ethnographic methods such as participant observations, interviews and document analysis. Findings: - Based on a literature review and research in water companies motivation and maturity based on Crowther (2006...

  19. CSR - en lönsam utmaning : Hur har begreppet CSR tolkats på företaget Saab?

    OpenAIRE

    Bigestans, Maija; Sävenstedt, Jenny

    2012-01-01

    Behovet av ett gemensamt arbete för ett hållbart samhälle är idag mer påtagligt än någonsin. Begreppet CSR (Corporate Social Responsibility) förekommer ofta i diskussioner om vilken roll företag har i denna process. Då de flesta definitioner av CSR är mycket generella och ger bristande vägledning i utförandet av CSR-arbete finns det ett intresse i att undersöka hur ett företag som säger sig arbeta med CSR har valt att angripa begreppet. Syftet med rapporten var att undersöka hur företaget Saa...

  20. Single nucleotide polymorphisms in microRNA binding sites of oncogenes: implications in cancer and pharmacogenomics.

    Science.gov (United States)

    Manikandan, Mayakannan; Munirajan, Arasambattu Kannan

    2014-02-01

    Cancer, a complex genetic disease involving uncontrolled cell proliferation, is caused by inactivation of tumor suppressor genes and activation of oncogenes. A vast majority of these cancer causing genes are known targets of microRNAs (miRNAs) that bind to complementary sequences in 3' untranslated regions (UTR) of messenger RNAs and repress them from translation. Single Nucleotide Polymorphisms (SNPs) occurring naturally in such miRNA binding regions can alter the miRNA:mRNA interaction and can significantly affect gene expression. We hypothesized that 3'UTR SNPs in miRNA binding sites of proto-oncogenes could abrogate their post-transcriptional regulation, resulting in overexpression of oncogenic proteins, tumor initiation, progression, and modulation of drug response in cancer patients. Therefore, we developed a systematic computational pipeline that integrates data from well-established databases, followed stringent selection criteria and identified a panel of 30 high-confidence SNPs that may impair miRNA target sites in the 3' UTR of 54 mRNA transcripts of 24 proto-oncogenes. Further, 8 SNPs amidst them had the potential to determine therapeutic outcome in cancer patients. Functional annotation suggested that altogether these SNPs occur in proto-oncogenes enriched for kinase activities. We provide detailed in silico evidence for the functional effect of these candidate SNPs in various types of cancer.

  1. Evaluation of the prognostic benefit of identifying the probable primary site in cancer of unknown primary

    Directory of Open Access Journals (Sweden)

    Das Joyutpal

    2015-09-01

    Full Text Available With the development of site-specific cancer therapy, identifying the primary origin allows the oncologist to personalise therapy for patients with the cancer of unknown primaries (CUPs. At present, immunohistochemistry (IHC screening is the standard method used to postulate the primary site in CUP. In this retrospective study, we evaluated the prognostic benefit of identifying the primary site in CUP. All 84 patients who presented with suspected CUP to the Royal Stoke University Hospital between 2011 and 2012 were included in our study. Forty-eight percent (40/84 of these patients were unable to undergo necessary investigations to identify primary sites because of poor performance status. IHC screening was able to postulate the primary site in 59% (26/44 of the remaining patients with confirmed CUP. Therefore, the primary site was not identified in a significant proportion of patients with CUP. The median survival of confirmed CUP with probable primary site was 2.0 months (95% confidence interval (CI: 1.2 to 2.9 months, whereas the median survival of confirmed CUP with no probable primary site was 4.1 months (95% CI: 1.5 to 9.7 months. This difference in survival time was statistically significant. In addition, using the Cox regression model, we found that patients with confirmed CUP with primary sites had prognostically unfavourable diseases with a shorter median survival, regardless of the age of disease onset, gender, sites of metastases or number of metastases. One approach to improve the survival would be to start systemic therapy at the earliest possible opportunity rather than waiting for all investigation results, such as IHC.

  2. Joint analysis of site-specific cancer risks for the atomic bomb survivors

    International Nuclear Information System (INIS)

    Statistical methods are presented for joint analysis of site-specific cancer risks for the atomic-bomb survivors. Previous analyses of these data, aside from those on leukemia, have been made either without regard to cancer type, or separately for types or classes of cancers. Clearly, analyses without regard to cancer type are less than satisfactory. The primary advantages of joint, rather than separate, analyses are that (1) models can be fitted with parameters common to cancer types, which can allow more-precise estimation of effects of interest, (2) significance tests can be used to compare type-specific risks, and (3) a clearer understanding may be obtained of risk-modification factors such as sex, age at exposure, and time since exposure. Joint analysis is straightforward, entailing primarily the incorporation of another factor for cancer type in the usual cross-tabulation of the data for analysis. The use of these methods is illustrated in an analysis of the three categories of cancer studied by the fifth Advisory Committee on the Biological Effects of Ionizing Radiation (BEIR V): digestive, respiratory, and other solid tumors. Based on this analysis, some criticism is made of the BEIR V-preferred models. Since the proposed methods are applicable to models for either relative or absolute risks, some comments on the use of explicit models for the absolute excess risk are also given. Although some of the gains from joint analysis are apparent from the results here, it will be important to use these methods with a more suitable choice of cancer classes and for cancer incidence data in which the diagnoses are more accurate. (author)

  3. The Balance between Internally and Externally Oriented CSR - A case study of Danish SMEs

    DEFF Research Database (Denmark)

    Aagaard, Annabeth; Lemmergaard, Jeanette

    -sized companies, SMEs. This study explores how four Danish SMEs have integrated CSR, and how the levels of external, internal and diagonal integration affect the qualitative and quantitative results of CSR. Whereas external CSR integration constitutes the external CSR communication and involvement of customers......, suppliers and other stakeholders, the internal CSR integration is explained and measured through the level of employee involvement and the content and the effects of internal oriented CSR activities and communication. The diagonal integration is understood as integration with the business strategy.......Corporate social responsibility (CSR) has become an acknowledged and well-established strategic approach in both theory and practice. A large majority of the existing literature emphasises CSR integration within larger corporations, although CSR also plays a pivotal role in small to medium...

  4. Corporate Social Responsibility (CSR Effectiveness in the Greek Professional Sport Context

    Directory of Open Access Journals (Sweden)

    John Douvis

    2015-03-01

    Full Text Available The present study examined CSR evaluation issues regarding the effectiveness of CSR activities in Greek professional sport organizations. The initial results illustrated a general absence of CSR effectiveness evaluation. The findings of the study revealed that the majority of respondents have reported that in fact CSR performance is not measured mainly because of a lack of a methodology or a common framework. A major barrier to CSR assessment and evaluation practices is represented by the respondents’ perceptions with respect to the nature of CSR. However, executives and managers mentioned a range of estimations to assess the impacts of their CSR actions, thus CSR effectiveness underlies subjective assessments of positive effect observations. Based on the results and the literature, the present study discusses the implications regarding the issue of CSR measurement and evaluation in Greek professional sport organizations.

  5. CSR AND SUSTAINABILITY: AN INVESTIGATION INTO THE PRACTICE OF ONLINE CSR INITIATIVES BY SECONDARY MARKET LISTED COMPANIES IN MALAYSIA

    OpenAIRE

    Nazahah Abd Rahim

    2013-01-01

    Corporate social responsibility (CSR) initiatives are being approached by corporations in so many ways and the most common in forms of campaigns, printed brochures, posters and sponsorships. This is becoming a problem because when corporations use existing resources to carry out their CSR initiatives, sometimes they are being carried away as not to think about whether they are going to have enough resources for future use, so as to become sustainable. But, there is another way of how corporat...

  6. The Strategic Value of Corporate Social Responsibility (CSR): Leveraging WSP Group’s CSR Strategy to Implement Its Sustainability Policy

    OpenAIRE

    Iskender, Khatira

    2010-01-01

    Through its impact on the built environment, construction plays a central role in the UK government’s drive to promote sustainable growth and development. Therefore, Corporate Social Responsibility (CSR) has become a growing area of interest for engineering and design consulting firms, such as WSP, within the construction industry as their stakeholder bases expand and expectations regarding the firm’s conduct also rise. This paper investigates WSP’s approach to CSR by addressing the following...

  7. A comparative content analysis of CSR strategies oriented to environmental issues between Greek and European CSR practices

    OpenAIRE

    Metaxas, Theodore; Tsavdaridou, Maria

    2011-01-01

    The scope of this research is to examine the way Greek companies contribute to the protection of the environment by investigating the CSR reports. In addition, there will be a comparative content analysis of Greek and European companies which will focus on the environmental aspect of the companies CSR strategy. Issues like recycling, environmental awareness, restoration of abandon places like quarrying, energy conservation, environmental education, green buildings, appliance of environmental ...

  8. CSR:以责任为名%CSR Becoming a Key Factor for Enterprise

    Institute of Scientific and Technical Information of China (English)

    慕名

    2009-01-01

    @@ "天堂不是建筑在公司的损益表上面,而是建在每个人尽责服务上面."虽然是上世纪20年代的一句话,但因为其拉开了CSR(Corporate social responsibility,即企监社会责任) "进化史"的大幕这一特殊意义而被后人屡屡提起.而且从当下来看,CSR受关注的程度更是与日俱增,越来越成为一个全球性的话题.

  9. A Novel CSR-Based Sparse Matrix-Vector Multiplication on GPUs

    OpenAIRE

    Guixia He; Jiaquan Gao

    2016-01-01

    Sparse matrix-vector multiplication (SpMV) is an important operation in scientific computations. Compressed sparse row (CSR) is the most frequently used format to store sparse matrices. However, CSR-based SpMVs on graphic processing units (GPUs), for example, CSR-scalar and CSR-vector, usually have poor performance due to irregular memory access patterns. This motivates us to propose a perfect CSR-based SpMV on the GPU that is called PCSR. PCSR involves two kernels and accesses CSR arrays in ...

  10. Implementation of CSR concept in manufacturing SMEs

    Directory of Open Access Journals (Sweden)

    Szczanowicz Justyna

    2014-05-01

    Full Text Available W artykule podejmuje się próbę zaproponowania modelu wdrażania koncepcji społecznej odpowiedzialności biznesu w małych i średnich przedsiębiorstwach produkcyjnych. Na podstawie badań PARP przedstawia się problem jakim jest słaba kondycja SCR w sektorze MSP. Sugeruje się podejście w którym kluczowym aspektem są poziomy społecznej odpowiedzialności biznesu rozumiane jako fundamenty na których przedsiębiorstwo nadbudowuje swoją konkurencyjność. W pracy podkreśla się również inwestycję w praktyki istotne z punktu widzenia kluczowych interesariuszy celem zwiększenie efektywności działań CSR rozumianych jako podniesienie konkurencyjności przedsiębiorstwa.

  11. Splice site mutations in mismatch repair genes and risk of cancer in the general population

    DEFF Research Database (Denmark)

    Thomsen, Mette; Nordestgaard, Børge G; Tybjærg-Hansen, Anne;

    2013-01-01

    We tested the hypothesis that splice site variations in MSH2 and MLH1 are associated with increased risk of hereditary non-polyposis colorectal cancer (HNPCC) and of cancer in general in the general population. In a cohort of 154 HNPCC patients with sequenced MSH2 and MLH1, we identified four...... possible splice-site mutations, which we subsequently genotyped in more than 9,000 individuals from the general population. Allele frequencies in the general population were 0 % for 942+3A>T in MSH2, 0.05 % for 307-19A>G, 0.005 % for 1,667+(2-8)del(taaatca);ins(attt), and 4.4 % for 1039-8T>A in MLH1. Odds...

  12. Prostate cancer guidelines on Web 2.0-based sites: the screening dilemma continues online.

    Science.gov (United States)

    Friedman, Daniela B; Koskan, Alexis; Rose, India D

    2011-03-01

    Little is known about prostate cancer (PrCA) screening information on participatory, interactive, and consumer-generated websites collectively referred to as Web 2.0. A content analysis was conducted of PrCA resources on four highly trafficked Web 2.0 social bookmarking sites. A total of 127 webpages were analyzed. Most content was from news websites (48.9%) and blogs (37.8%). PrCA screening was mentioned on 95.3% of pages; only 30.7% discussed the prostate-specific antigen test. Less than half (43.8%) mentioned current screening guidelines. PrCA content is inconsistent on Web 2.0 sites. Future research should assess the readability and usability of Web 2.0 cancer resources.

  13. 企业社会责任研究——CSR,CSR2,CSP

    Institute of Scientific and Technical Information of China (English)

    王新新; 杨德锋

    2007-01-01

    企业社会责任作为国外研究的热点,已有很长的历史,研究的中心几经转移.因企业社会责任(CSR)没有指明企业如何做社会事务,产生了企业社会响应(CSR2),因CSR对社会责任的概括不够全面,产生了企业社会绩效(CSP).对于企业为何要承担社会责任,学者们主要从工具理论等四个大的理论方面给予解释.企业承担社会责任,能够使企业获得一定的竞争优势,并且大部分的实证研究支持CSP和CFP正相关的结论.

  14. Ovarian cancer: the Fallopian tube as the site of origin and opportunities for prevention

    Directory of Open Access Journals (Sweden)

    Sophia HL George, PhD

    2016-05-01

    Full Text Available High-grade serous carcinoma is the most common and aggressive histotype of epithelial ovarian cancer, and it is the predominant histotype associated with hereditary breast and ovarian cancer syndrome (HBOC. Mutations in BRCA1 and BRCA2 are responsible for most of the known causes of HBOC, while mutations in mismatch repair genes and several genes of moderate penetrance are responsible for the remaining known hereditary risk. Women with a history of familial ovarian cancer or with known germline mutations in highly penetrant genes are offered the option risk-reducing surgery, which involves the removal of the ovaries and fallopian tubes (salpingo-oophorectomy. Growing evidence now supports the fallopian tube epithelia as an etiological site for the development of HGSC and consequently, salpingectomy alone is emerging as a prophylactic option. This review discusses the site of origin of epithelial ovarian cancer, the rationale for risk-reducing salpingectomy in the high-risk population and opportunities for salpingectomy in the low-risk population.

  15. Do founder mutations characteristic of some cancer sites also predispose to pancreatic cancer?

    Science.gov (United States)

    Lener, Marcin R; Scott, Rodney J; Kluźniak, Wojciech; Baszuk, Piotr; Cybulski, Cezary; Wiechowska-Kozłowska, Anna; Huzarski, Tomasz; Byrski, Tomasz; Kładny, Józef; Pietrzak, Sandra; Soluch, Agnieszka; Jakubowska, Anna; Lubiński, Jan

    2016-08-01

    Understanding of the etiology and risk of pancreatic cancer (PaCa) is still poorly understood. This study evaluated the prevalence of 10 Polish founder mutations in four genes among PaCa patients and assessed their possible association with the risk of disease in Poland. In the study 383 PaCa patients and 4,000 control subjects were genotyped for founder mutations in: BRCA1 (5382insC, 4153delA, C61G), CHEK2 (1100delC, IVS2 + 1G > A, del5395, I157T), NBS1 (657del5) and PALB2 (509_510delGA, 172_175delTTGT). A statistically significant association between the 657del5 mutation and an increased risk of pancreatic cancer was observed for NBS1 gene. The Slavic NBS1 gene mutation (657delACAAA) was detected in 8 of 383 (2.09%) unselected cases compared with 22 of 4,000 (0.55%) controls (OR: 3.80, p = 0.002). The PALB2 509_510delGA and 172_175delTTGT mutations combined were seen in 2 (0.52%) unselected cases of PaCa and in 8 (0.20%) of 4,000 controls (OR: 2.61, p = 0.49). For BRCA1, the three mutations combined were detected in 4 of 383 (1.04%) PaCa patients and in 17 of 4,000 (0.42%) controls (OR: 2.46, p = 0.20). CHEK2 mutations were not associated with the risk of pancreatic cancer (OR: 1.11, p = 0.72). The founder mutation in NBS1 (657del5) was associated with an increased risk of PaCa in heterozygous carriers, indicating that this mutation appears to predispose to cancer of the pancreas. By identifying pancreatic cancer risk groups, founder mutation testing in Poland should be considered for people at risk for PaCa. PMID:27038244

  16. Worry Is Good for Breast Cancer Screening: A Study of Female Relatives from the Ontario Site of the Breast Cancer Family Registry

    OpenAIRE

    Li Rita Zhang; Chiarelli, Anna M; Gord Glendon; Lucia Mirea; Knight, Julia A.; Andrulis, Irene L.; Paul Ritvo

    2012-01-01

    Background. Few prospective studies have examined associations between breast cancer worry and screening behaviours in women with elevated breast cancer risks based on family history. Methods. This study included 901 high familial risk women, aged 23–71 years, from the Ontario site of the Breast Cancer Family Registry. Self-reported breast screening behaviours at year-one followup were compared between women at low (N = 305), medium (N = 433), and high (N = 163) levels of baseline breast canc...

  17. Low energy electron cooler for the Heidelberg CSR

    International Nuclear Information System (INIS)

    The cryogenic storage ring (CSR) is currently under development at MPI-K in Heidelberg. The CSR is an electrostatic ring intended for storing ions in the 20-300 keV energy range (E/Q) in cryogenic environment at temperature down to 2 K. CSR will be equipped with an electron cooler which has to combine cooler and electron target functions. For cooling operation at given ion energies corresponding electron energies are in the range from 160 down to a few eV. Main problems in such operation mode are the decrease of electron beam intensity, the degradation of the electron longitudinal energy spread and the distortion of stored low energy ion trajectories during beams merging. For the CSR a new merging beam section layout together with a photocathode based cold electron source (tested at the Heidelberg TSR) have been proposed. In this paper we present the design of CSR electron cooler including the cryogenic implementation together with numerical calculations of the electron beam longitudinal and transverse energy spread in merged beam section

  18. Using CSR to mitigate information asymmetry in the banking sector

    Directory of Open Access Journals (Sweden)

    Semenescu Andreea

    2015-12-01

    Full Text Available The paper examines the power of corporate social responsibility to reduce information asymmetry and to act as a marketing instrument in the banking sector. Trust is the most important asset of a bank. Therefore, banks are motivated to use the most effective instruments to diminish information asymmetry with their stakeholders. The fact that cash disbursements in CSR actions are not directed towards shareholders makes them more valuable signals to other stakeholders regarding the financial soundness of the bank. The empirical study conducted based on limited dependent variable models supports the effectiveness of the CSR as marketing instrument in banking. It reveals the circumstances associated to a higher probability of an active CSR policy conducted by a banking institution. The results support the hypothesis that in the banking sector CSR is perceived as an instrument which helps stakeholders reduce information asymmetry. As marketing instrument, CSR contributes to increasing the tangibility of the banking products, decreasing their perceived variability and thus making them more attractive for the clients and allowing for differentiation between competitors.

  19. The integration of corporate social responsibility (CSR) initiatives into business activities

    DEFF Research Database (Denmark)

    Knudsen, Jette Steen

    2013-01-01

    While proponents of corporate social responsibility (CSR) have suggested that CSR initiatives should be integrated into mainstream business activities as 'strategic CSR' or 'shared value', research is lacking that explores how CSR programmes are integrated in companies. This paper compares CSR...... initiatives with human resource management (HRM) activities, which have a longer tradition of being integrated into company strategy. The focus is on gender diversity and CSR in a US multinational corporation (MNC). The MNC sees gender diversity as an integral part of business activities. In contrast, the MNC...... lacks a clear justification for the much broader CSR agenda, CSR activities seem not to reflect an overall set of values or purpose, integration into business activities is unclear, and targets are lacking....

  20. csrT Represents a New Class of csrA-Like Regulatory Genes Associated with Integrative Conjugative Elements of Legionella pneumophila

    Science.gov (United States)

    Abbott, Zachary D.; Flynn, Kaitlin J.; Byrne, Brenda G.; Mukherjee, Sampriti; Kearns, Daniel B.

    2015-01-01

    ABSTRACT Bacterial evolution is accelerated by mobile genetic elements. To spread horizontally and to benefit the recipient bacteria, genes encoded on these elements must be properly regulated. Among the legionellae are multiple integrative conjugative elements (ICEs) that each encode a paralog of the broadly conserved regulator csrA. Using bioinformatic analyses, we deduced that specific csrA paralogs are coinherited with particular lineages of the type IV secretion system that mediates horizontal spread of its ICE, suggesting a conserved regulatory interaction. As a first step to investigate the contribution of csrA regulators to this class of mobile genetic elements, we analyzed here the activity of the csrA paralog encoded on Legionella pneumophila ICE-βox. Deletion of this gene, which we name csrT, had no observed effect under laboratory conditions. However, ectopic expression of csrT abrogated the protection to hydrogen peroxide and macrophage degradation that ICE-βox confers to L. pneumophila. When ectopically expressed, csrT also repressed L. pneumophila flagellin production and motility, a function similar to the core genome's canonical csrA. Moreover, csrT restored the repression of motility to csrA mutants of Bacillus subtilis, a finding consistent with the predicted function of CsrT as an mRNA binding protein. Since all known ICEs of legionellae encode coinherited csrA-type IV secretion system pairs, we postulate that CsrA superfamily proteins regulate ICE activity to increase their horizontal spread, thereby expanding L. pneumophila versatility. IMPORTANCE ICEs are mobile DNA elements whose type IV secretion machineries mediate spread among bacterial populations. All surveyed ICEs within the Legionella genus also carry paralogs of the essential life cycle regulator csrA. It is striking that the csrA loci could be classified into distinct families based on either their sequence or the subtype of the adjacent type IV secretion system locus. To

  1. Effects of Core-Shell Rubber (CSR) Nanoparticles on the Cryogenic Fracture Toughness of CSR Modified Epoxy

    Science.gov (United States)

    Wang, Jun; Magee, Daniel; Schneider, Judy; Cannon, Seth

    2009-01-01

    This study investigated the effects of core-shell rubber (CSR) nanoparticles on the mechanical properties and fracture toughness of an epoxy resin at ambient and liquid nitrogen (LN2) temperatures. Varying amounts of Kane Ace(Registered TradeMark) MX130 and Kane Ace(Registered TradeMark) MX960 toughening agent were added to a commercially available EPON 862/Epikure W epoxy resin. Elastic modulus was calculated using quasi-static tensile data. Fracture toughness was evaluated by the resulting breaking energy measured in Charpy impact tests conducted on an instrumented drop tower. The size and distribution of the CSR nanoparticles were characterized using Transmission Electron Microscopy (TEM) and Small Angle X-ray Scattering (SAXS). Scanning Electron Microscopy (SEM) was used to study the fracture surface morphology. The addition of the CSR nanoparticles increased the breaking energy with negligible change in elastic modulus and ultimate tensile stress (UTS). At ambient temperature the breaking energy increased with increasing additions of the CSR nanoparticles up to 13.8wt%, while at LN2 temperatures, it reached a plateau at much lower CSR concentration.

  2. PENGARUH PENERAPAN CORPORATE SOCIAL RESPONSIBILITY ( CSR ) TERHADAP CITRA PERUSAHAAN PADA PT. HADJI KALLA CABANG SULTAN ALAUDDIN

    OpenAIRE

    MAJID, PARAMITA

    2012-01-01

    - This research aims to determine the influence either together or partially between CSR (Corporate Social Responsibility) to corporate image in PT. Hadji Kalla Cabang Sultan Alaudin, Makassar area, that being measured from CSR variables which is Profit, People, and Planet. Expectedly the information obtained from this research can be used by companies to increase CSR activities and quality of CSR programs so that more can enh...

  3. Comparative Study of CSR reporting in Finnish and UK listed Companies

    OpenAIRE

    Aryal, Nabin

    2014-01-01

    This is the comparative study of CSR reporting in Finnish and UK listed companies. This thesis provides user with knowledge on Corporate Social Responsibility (CSR) reporting and shows the comparative study on how CSR reporting is carried out in Finnish and UK listed companies. This study is carried out using qualitative study. In order to know the reporting pattern in Finland and UK three listed companies from both the countries are selected and their CSR reports have been analyzed. The aim ...

  4. Web communication of CSR and financial performance: Study applied to catalan meat companies

    OpenAIRE

    Alejandra Aramayo García; Nuria Arimany-Serrat; Clara Uribe Salazar; Anna Sabata Aliberch

    2016-01-01

    Purpose: Understanding the relationship between CSR communication on corporate websites and the financial performance of Catalan meat companies. Design/methodology/approach: Qualitative and quantitative analysis of the CSR communication variables of corporate websites identifying the companies with the best CSR web communication’s practices, and economic and financial comparative analysis. It also modelled the financial returns to determine whether CSR communication, as an independent vari...

  5. CSR strategie jako součást marketingové komunikace

    OpenAIRE

    Pospíšilová, Lucie

    2014-01-01

    The main goal of this diploma thesis is to propose a long-term CSR strategy for selected company, primarily focused on social pillar and putting emphasis on its communication. The CSR strategy is proposed based on evaluation of current company's CSR activities, concerning criteria of new global CSR concept of the company, as well as reflecting consumer's perspective and their perception of selected company's brand. Furthermore, the strategy works with local market and social specifics and gen...

  6. Examining online CSR communication within the auditing and consulting industry: the big 4 companies

    OpenAIRE

    Larnemaa, Anne

    2013-01-01

    Objectives of the Study First, the purpose of this study was to examine the online CSR communication of the Finnish Big 4 companies, that is KPMG, PwC, Deloitte and Ernst & Young (EY). The aim was to identify what these companies understand as "CSR" and how they communicate about responsibility issues online. Second, this study examined the online CSR communication of Ernst & Young on a global level and found out what kind of a global CSR communication strategy Ernst & Young has developed...

  7. CSR Communication Strategies for Twitter : Microblogging as a Tool for Public Relations

    OpenAIRE

    Etter, Michael; Plotkowiak, Thomas; Stanoevska-Slabeva, Katarina

    2011-01-01

    This study explores how companies use the social media tool Twitter for CSR communication. By analyzing CSR communication conducted by 30 most central corporate Twitter accounts, identified through social network analysis within a CSR-Twitter-network consisting of 19'855 Twitter members, we contribute to the understanding of Twitter's role for CSR communication and public relations. Manually conducted content analysis of totally 41‘864 corporate Twitter messages gives insights into different ...

  8. Corporate Social Responsibility (CSR) and Sustainability in Asian Luxury Hotels: Policies, Practices and Standards

    OpenAIRE

    Vimolboon Cherapanukorn; Kirsten Focken

    2014-01-01

    The tourism and hospitality industry claims to embrace the concept of corporate social responsibility (CSR) but it seems unclear how and if companies integrate CSR activities into the core business and how they demonstrate real impacts and positive changes. The purpose of this research is to understand how Asian luxury hotels communicate about their CSR policies, practices and standards. It gives insights of best practices of CSR from luxury hotel groups that operate predominantly in Asia. Th...

  9. Analýza CSR ve vybrané firmě

    OpenAIRE

    Hořejší, Renata

    2012-01-01

    This thesis deals with Corporate Social Responsibility. In the theoretical part the basic concepts of Corporate Social Responsibility are determined and introduced initiatives dealing with CSR at national, European and global level. The definition of methods for measuring CSR, communication, implementation and benefits of CSR for the company are also included in this part. The practical part is focused on the company Skupina ČEZ. There is company presentation, particular CSR activities and re...

  10. Sustainability in the Tobacco Sector? A Comparative Study of CSR Activities in Vietnam and the UK

    OpenAIRE

    Trinh, Ngoc Huyen

    2013-01-01

    Since controversial industry sectors started to conduct corporate social responsibility (CSR) initiatives and promote themselves as socially responsible citizens, it becomes phenomenon that critical non-governmental organizations (NGOs) react to CSR communication by highlighting the shortcomings of CSR activities; especially what infringe the ethical stances. Moving beyond the moral argument and ethical-based values that portray the debates underpinning CSR concepts and ideas, this work aims ...

  11. Understanding strategic corporate social responsibility (CSR) in Finnish consumer goods industry

    OpenAIRE

    Kuusela, Nina

    2015-01-01

    Objectives: The main objective of the study is to understand how the various elements of strategic Corporate Social Responsibility (CSR) are utilized as a source of differentiation, and even as a competitive advantage for a company. The study explores the different company approaches to CSR, and widens the understanding of strategic CSR through a Finnish case company that aims to utilize CSR as a competitive advantage. The theoretical background of this study lies in academic literature a...

  12. The Flavour of CSR in Indonesia: A comparative study of 3 Indonesian State-Owned Banks

    OpenAIRE

    Sapphira, Anya Sapphira

    2011-01-01

    CSR has been recognized in Indonesia for the past decade, and it keeps developing. Together with other developing countries in Asia, Indonesia shows more attention on the issue of CSR and its implementation. A significant step related to CSR in Indonesia is when the government of Indonesia released the Social and Environmental Responsibility (TJSL) regulation in 2007. Although until now, the regulation has not been equipped with practical standard such as government regulation, on CSR definit...

  13. How CSR creates value for mutual insurers: a strategic-economic model for managers

    OpenAIRE

    Lageu, Faye

    2009-01-01

    Over the last 20 years, corporate social responsibility (CSR) has worked its way up the business and political agenda. Evidence of firms’ increased CSR investments are not matched,however, by clear evidence of how CSR creates value for firms. As recession takes hold,managers will increasingly be required to review their inputs and outputs and consider how their various resource allocations create value. That some firms invest in CSR suggests it can provide a competitive advantage; yet...

  14. HVORDAN INTEGRERES CSR I SMÅ OG MELLEMSTORE VIRKSOMHEDER OG HVAD PÅVIRKER INTEGRATIONSFORMEN?

    DEFF Research Database (Denmark)

    Aagaard, Annabeth

    2016-01-01

    CSR integration i små og mellemstore virksomheder (SMV’er) mangelfuld, og flere studier påpeger at der er væsentlig forskel på CSR og CSR integration når man sammenligner store virksomheder og SMV’er. Denne artikel ønsker at undersøge, hvordan små og mellemstore virksomheder integrerer CSR og hvad der...

  15. The Danish CSR Reporting Requirement as Reflexive Law

    DEFF Research Database (Denmark)

    Buhmann, Karin

    2013-01-01

    With effect for financial years beginning January 2009 or later, the Danish Financial Statements Act and related governmental regulations require large Danish companies and institutional investors to submit an annual Corporate Social Responsibility (CSR) report. Through application of reflexive law...... theory and an analysis of the preparatory works and guidelines for the CSR-reporting requirement, this article demonstrates that the reporting requirement aims to obtain public policy objectives through stimulating companies to self-regulate based on reflection on their impact on society. The legislative...... history and reporting guidelines indicate a definite objective of drawing on the CSR paradigm to complement national substantive law, engaging company practice in the implementation of national public policy goals and in the extraterritorial implementation of public policy goals related to conditions...

  16. The injection beam lines of the cryogenic storage ring (CSR)

    International Nuclear Information System (INIS)

    At the Max-Planck-Institute for Nuclear Physics in Heidelberg an electrostatic cryogenic storage ring (CSR) is under construction. The ions for the CSR will be provided by two ion sources with up to 60kV and 300 kV potential, respectively. The layout of the beamlines connecting the ion sources with the CSR is presented. They will be merged using an electrostatic deflector with an opening in the outer electrode, thereby allowing quick switching between the two ion sources. In order to determine the influence of the opening on the beam optics the deflector has been modeled and a modified transport matrix has been derived. An additional beamline element is a detachment region for the neutralization of a negative ion beam by photodetachment. The potential of the detachment region defines the precise energy of the neutral particles. Calculations of the ion beam optics using the MAD X code are described.

  17. Observation of CSR spectrum from JAEA-ERL

    International Nuclear Information System (INIS)

    The energy recovery linac (ERL) is able to generate high-power coherent synchrotron radiation (CSR) in the terahertz and the millimeter-wave regions, because it produces shorter bunches than usual storage rings and a higher current than conventional linacs. The spectrum of CSR has been measured at the JAEA-ERL in the wavenumber range from 0.5 to 15cm-1. The detected power was 2x10-4 W/cm-1 at 2.5 cm-1 for the average beam current of 17.7 μA. When the infrared FEL was operated with the undulator in the ERL, the CSR spectrum was shifted to the longer wavelengths because of the energy broadening of the electron beam. (author)

  18. Analysis of risk factors of surgical site infections in breast cancer

    Institute of Scientific and Technical Information of China (English)

    GAO Yang-xu; XU Ling; YE Jing-ming; WANG Dong-min; ZHAO Jian-xin; ZHANG Lan-bo; DUAN Xue-ning; LIU Yin-hua

    2010-01-01

    Background Adjuvant chemotherapy has become an important component of standard therapy for breast cancer. However, until now, there have been few reports on the surgical site infections (SSI) after breast cancer surgery, specially after adjuvent chemotherapy. To study the risk factors of SSI of breast cancer, we analyzed patients diagnosed with breast cancer and treated with surgery. Methods Fifty-five patients diagnosed with breast cancer and received breast conserving or modified radical operations in our hospital during January 2008 to March 2008 were selected. Factors (patients' age, body mass index (BMI), diabetes mellitus, no or administered adjuvant chemotherapy, with or without onset of myelosuppression and the degree, surgical approaches, duration of operation, postoperative drainage duration and total drainage volume) associated with SSI were retrospectively reviewed and statistically analyzed by single factor analysis. Results Five patients suffered SSI (5/55, 9.1%); nineteen receiving adjuvant chemotherapy experienced Grade III+ myelosuppression, among which 4 had SSI; only 1 out of the remaining 36 patients without adjuvant chemotherapy had SSI. The difference between the two groups was significant (P=0.043). The incidence of SSI in patients with postoperative drainage tube indwelling longer than 10 days was 5/21, whereas no SSI occurred in that less than 10 days (R=0.009). in our study, there was no significient difference in other associated factors. Conclusions Concurrent Grade III+ myelosuppression after adjuvant chemotherapy is an important risk factor of SSI in breast cancer and needs further study. No SSI was detected with indwelling time of post operative drainage less than 10 days.

  19. Variation in the group B Streptococcus CsrRS regulon and effects on pathogenicity

    NARCIS (Netherlands)

    Jiang, Sheng-Mei; Ishmael, Nadeeza; Hotopp, Julie Dunning; Puliti, Manuela; Tissi, Luciana; Kumar, Nikhil; Cieslewicz, Michael J.; Tettelin, Herve; Wesselsl, Michael R.

    2008-01-01

    CsrRS (or CovRS) is a two-component regulatory system that controls expression of multiple virulence factors in the important human pathogen group B Streptococcus (GBS). We now report global gene expression studies in GBS strains 2603V/R and 515 and their isogenic csrR and csrS mutants. Together wit

  20. A Novel CSR-Based Sparse Matrix-Vector Multiplication on GPUs

    Directory of Open Access Journals (Sweden)

    Guixia He

    2016-01-01

    Full Text Available Sparse matrix-vector multiplication (SpMV is an important operation in scientific computations. Compressed sparse row (CSR is the most frequently used format to store sparse matrices. However, CSR-based SpMVs on graphic processing units (GPUs, for example, CSR-scalar and CSR-vector, usually have poor performance due to irregular memory access patterns. This motivates us to propose a perfect CSR-based SpMV on the GPU that is called PCSR. PCSR involves two kernels and accesses CSR arrays in a fully coalesced manner by introducing a middle array, which greatly alleviates the deficiencies of CSR-scalar (rare coalescing and CSR-vector (partial coalescing. Test results on a single C2050 GPU show that PCSR fully outperforms CSR-scalar, CSR-vector, and CSRMV and HYBMV in the vendor-tuned CUSPARSE library and is comparable with a most recently proposed CSR-based algorithm, CSR-Adaptive. Furthermore, we extend PCSR on a single GPU to multiple GPUs. Experimental results on four C2050 GPUs show that no matter whether the communication between GPUs is considered or not PCSR on multiple GPUs achieves good performance and has high parallel efficiency.

  1. Promoting Reading Comprehension, Content Learning, and English Acquisition through Collaborative Strategic Reading (CSR).

    Science.gov (United States)

    Klingner, Janette K.; Vaughn, Sharon

    1999-01-01

    Describes procedures for teaching Collaborative Strategic Reading (CSR), in which students of mixed reading and achievement levels work in small, cooperative groups to assist one another in applying reading strategies to facilitate their comprehension of content-area text. Discusses whole-class instruction of CSR strategies, implementing CSR in…

  2. The bad, the ugly and the good: new challenges for CSR communication

    NARCIS (Netherlands)

    W.J.L. Elving; U. Golob; K. Podnar; A. Ellerup-Nielsen; C. Thomson

    2015-01-01

    Purpose - This editorial is an introduction to the special issue on CSR Communication attached to the second CSR Communication Conference held in Aarhus (Denmark) in September 2013. The purpose of this paper is to critically evaluate the role of CSR communication and the development of theory and pr

  3. How Does It Fit? Exploring the Congruence Between Organizations and Their Corporate Social Responsibility (CSR) Activities

    NARCIS (Netherlands)

    Jong, de Menno D.T.; Meer, van der Mark

    2015-01-01

    Several studies have focused on the effects of corporate social responsibility (CSR) fit on external stakeholders’ evaluations of CSR activities, attitudes towards companies or brands, and behaviors. The results so far have been contradictory. A possible reason may be that the concept of CSR fit is

  4. Port site and distant metastases of gallbladder cancer after laparoscopic cholecystectomy diagnosed by positron emission tomography

    Institute of Scientific and Technical Information of China (English)

    Jian-Bin Hu; Xiao-Nan Sun; Jing Xu; Chao He

    2008-01-01

    We report port site and distant metastases of unsuspected gallbladder cancer after laparoscopic cholecystectomy diagnosed by positron emission tomography (PET) in two patients. Patient 1, a 72-year-old woman was diagnosed as cholelithiasis and cholecystitis and received laparoscopic cholecystectomy. Unsuspected gallbladder cancer was discovered with histological result of well-differentiated squamous cell carcinoma of the gallbladder infiltrating the entire wall. A PET scan using F-18-fluorodeoxygluccee (FDG-PET) before radical resed:ion revealed residual tumor in the gallbladder fossa and recurrence at port site and metastases in bilateral hilar lymph nodes. Patient 2, a 69-year-old woman underwent laparoscopic cholecystectomy more than one year ago with pathologically confirmed unsuspected adenosquamous carcinoma of stage pTlb. At 7-mo follow-up after surgery, the patient presented with nodules in the periumbilical incision. Excisional biopsy of the nodule revealed adenosquamous carcinoma. The patient was examined by FDG-PET, demonstrating increased FDG uptake in the right lobe of the liver and mediastinal lymph nodes consistent with metastatic disease. This report is followed by a discussion about the utility of FDG-PET in the gallbladder cancer.

  5. The Csr system regulates genome-wide mRNA stability and transcription and thus gene expression in Escherichia coli

    Science.gov (United States)

    Esquerré, Thomas; Bouvier, Marie; Turlan, Catherine; Carpousis, Agamemnon J.; Girbal, Laurence; Cocaign-Bousquet, Muriel

    2016-01-01

    Bacterial adaptation requires large-scale regulation of gene expression. We have performed a genome-wide analysis of the Csr system, which regulates many important cellular functions. The Csr system is involved in post-transcriptional regulation, but a role in transcriptional regulation has also been suggested. Two proteins, an RNA-binding protein CsrA and an atypical signaling protein CsrD, participate in the Csr system. Genome-wide transcript stabilities and levels were compared in wildtype E. coli (MG1655) and isogenic mutant strains deficient in CsrA or CsrD activity demonstrating for the first time that CsrA and CsrD are global negative and positive regulators of transcription, respectively. The role of CsrA in transcription regulation may be indirect due to the 4.6-fold increase in csrD mRNA concentration in the CsrA deficient strain. Transcriptional action of CsrA and CsrD on a few genes was validated by transcriptional fusions. In addition to an effect on transcription, CsrA stabilizes thousands of mRNAs. This is the first demonstration that CsrA is a global positive regulator of mRNA stability. For one hundred genes, we predict that direct control of mRNA stability by CsrA might contribute to metabolic adaptation by regulating expression of genes involved in carbon metabolism and transport independently of transcriptional regulation. PMID:27112822

  6. The Csr system regulates genome-wide mRNA stability and transcription and thus gene expression in Escherichia coli.

    Science.gov (United States)

    Esquerré, Thomas; Bouvier, Marie; Turlan, Catherine; Carpousis, Agamemnon J; Girbal, Laurence; Cocaign-Bousquet, Muriel

    2016-01-01

    Bacterial adaptation requires large-scale regulation of gene expression. We have performed a genome-wide analysis of the Csr system, which regulates many important cellular functions. The Csr system is involved in post-transcriptional regulation, but a role in transcriptional regulation has also been suggested. Two proteins, an RNA-binding protein CsrA and an atypical signaling protein CsrD, participate in the Csr system. Genome-wide transcript stabilities and levels were compared in wildtype E. coli (MG1655) and isogenic mutant strains deficient in CsrA or CsrD activity demonstrating for the first time that CsrA and CsrD are global negative and positive regulators of transcription, respectively. The role of CsrA in transcription regulation may be indirect due to the 4.6-fold increase in csrD mRNA concentration in the CsrA deficient strain. Transcriptional action of CsrA and CsrD on a few genes was validated by transcriptional fusions. In addition to an effect on transcription, CsrA stabilizes thousands of mRNAs. This is the first demonstration that CsrA is a global positive regulator of mRNA stability. For one hundred genes, we predict that direct control of mRNA stability by CsrA might contribute to metabolic adaptation by regulating expression of genes involved in carbon metabolism and transport independently of transcriptional regulation. PMID:27112822

  7. The single-mode CSR instability for a bunched beam

    CERN Document Server

    Heifets, S

    2003-01-01

    The coherent synchrotron radiation (CSR) instability at the shielding threshold may be driven by a single synchronous mode excited by the beam in the beam pipe. The instability in this case has been analyzed [1] in the coasting beam approximation neglecting synchrotron motion. The later becomes important at large time intervals in storage rings where it substantially affects the beam dynamics. The single-mode CSR instability of a bunched beam with the synchrotron motion taken into account is described in this paper both in linear and nonlinear regimes. Analysis is relevant to other instabilities where the interaction is dominated by a single mode.

  8. Vplyv CSR na image značky

    OpenAIRE

    Mičáková, Veronika

    2010-01-01

    The main aim of this diploma thesis is to discover an evidence of CSR influence upon brand image. More precisely, I will attempt to explore the impact of L'Oréal corporate social responsibility on L'Oréal Paris brand image. The concept of CSR, the center of the brand and brand image are described in the introduction. For better understanding, there are also practical examples provided. Chapter number three creates a fluent connecting link between theoretical and practical part, briefly charac...

  9. Theory and Simulation of CSR Microbunching in Bunch Compressors

    International Nuclear Information System (INIS)

    CSR microbunching instability in bunch compressors is studied both analytically and numerically. The iterative solutions of the integral equation for the instability provide approximate expressions of CSR microbunching due to initial density and energy modulation, and can be applied to a series of bending systems consisting of multiple compressor chicanes and transport lines. Two similar but independent simulation methods are developed and are compared to each other as well as with theory. We determine the total gain in density modulation for all bend systems of the Linac Coherent Light Source and discuss initial conditions that start the unstable process

  10. Nonlinear Regime of a Single-mode CSR Instability

    International Nuclear Information System (INIS)

    Close to the shielding threshold of synchrotron radiation in a toroidal waveguide the coherent synchrotron radiation (CSR) instability may be driven by a single synchronous mode. The linear analysis of the problem is presented elsewhere. In this paper we study a nonlinear regime of the single-mode CSR instability. We show that in the nonlinear regime the instability is described by a system of equations which, after a proper scaling, coincides with the 1D FEL instability theory. We present numeric and analytic analysis of the non-linear regime for the time interval large compared with the damping time taking into account radiation damping and diffusion due to the quantum fluctuations

  11. The single-mode CSR instability for a bunched beam

    International Nuclear Information System (INIS)

    The coherent synchrotron radiation (CSR) instability at the shielding threshold may be driven by a single synchronous mode excited by the beam in the beam pipe. The instability in this case has been analyzed [1] in the coasting beam approximation neglecting synchrotron motion. The later becomes important at large time intervals in storage rings where it substantially affects the beam dynamics. The single-mode CSR instability of a bunched beam with the synchrotron motion taken into account is described in this paper both in linear and nonlinear regimes. Analysis is relevant to other instabilities where the interaction is dominated by a single mode

  12. Theory and simulation of CSR microbunching in bunch compressors

    International Nuclear Information System (INIS)

    CSR microbunching instability in bunch compressors is studied both analytically and numerically. The iterative solutions of the integral equation for the instability provide approximate expressions of CSR microbunching due to initial density and energy modulation, and can be applied to a series of bending systems consisting of multiple compressor chicanes and transport lines. Two similar but independent simulation methods are developed and are compared to each other as well as with theory. They determine the total gain in density modulation for all bend systems of the Linac Coherent Light Source and discuss initial conditions that start the unstable process

  13. Impact on the magnetic compressor due to CSR

    Institute of Scientific and Technical Information of China (English)

    LIU Chu-Yu; WANG Fang; WANG Er-Dong; QUAN Sheng-Wen; HAO Jian-Kui; LU Xiang-Yang; ZHANG Bao-Cheng; ZHAO Kui

    2008-01-01

    When an electron bunch is compressed in a chicane compressor,the CSR (coherent synchrotron radiation) will induce energy redistribution along the bunch.Such energy redistribution will affect the longitudinal emittance as a direct consequence.It will also excite betatron oscillation due to the chromatic transfer functions,and hence a transverse emittance change.So,it is indispensable for us to find a way to alleviate the CSR-cansed emittance dilution and the bad result of chicane compressor in PKU-FEL.

  14. The Collectivity in Csr 129Xe+129Xe Collisions

    Science.gov (United States)

    Xie, Fei; Wu, Kejun; Liu, Feng

    The Heavy Ion Research Facility in Lanzhou (HIRFL) - Cooler Storage Ring (CSR), which can gather few hundreds MeV/nucleon for heavy ion beam energy in the external-target experiments, could make a significant contribution in studying the property of dense matter. By using a Relativistic Transport Model(ART1.0), we study the collectivity of identified hadrons in 129Xe+129Xe collisions in CSR energy regions. Our investigation indicates that the anisotropic flow reaches its extremum around 500 MeV/nucleon of beam energy. The system size and EOS dependence on anisotropic flow show that directed flow is very sensitive to the equation of state.

  15. LACK OF EXPERTS AS AN IDEAL INTRODUCTION TO CSR

    OpenAIRE

    Simone Matthaei

    2013-01-01

    The Federal Ministry of Labour and Social Affairs (Bundesministerium für Arbeit und Soziales, BMA) is supporting 73 projects in Germany using European Union (EU) funds in the amount of € 26 million. By providing the subsidies, the European Commission and the German Federal Government are hoping to implement Corporate Social Responsibility (CSR) among German small and medium-sized businesses (SMBs). The project run by Bonn-Rhein-Sieg University is one of these CSR projects. It is aimed at prov...

  16. CSR and Company Reputation - Case study of Nike

    OpenAIRE

    Valjakka, Mira

    2013-01-01

    During the 21st century, we have seen an enormous increase in the popularity of CSR, in corporate level as well as in public media. Society’s consciousness on the effects of individual behaviour has risen with increased awareness on environmental and societal issues such as global warming and human rights. Corporate catastrophes, such as BP oil spill in Gulf of Mexico in 20101, which was the biggest oil spill in history of United States, has woken companies to protect their CSR reputation. ...

  17. How much can we say about site-specific cancer radiation risks?

    Science.gov (United States)

    Preston, D L; Krestinina, L Yu; Sokolnikov, M E; Ron, E; Davis, F G; Ostroumova, E V; Gilbert, E S

    2010-12-01

    Studies of Mayak workers and people who lived along the Techa River have demonstrated significant associations between low-dose-rate radiation exposure and increased solid cancer risk. It is of interest to use the long-term follow-up data from these cohorts to describe radiation effects for specific types of cancer; however, statistical variability in the site-specific risk estimates is large. The goal of this work is to describe this variability and provide Bayesian adjusted risk estimates. We assume that the site-specific estimates can be viewed as a sample from some underlying distribution and use Bayesian methods to produce adjusted excess relative risk per gray estimates in the Mayak and Techa River cohorts. The impact of the adjustment is compared to that seen in similar analyses in the atomic bomb survivors. Site-specific risk estimates in the Mayak and Techa River cohorts have large uncertainties. Unadjusted estimates vary from implausibly large decreases to large increases, with a range that greatly exceeds that found in the A-bomb survivors. The Bayesian adjustment markedly reduced the range of the site-specific estimates for the Techa River and Mayak studies. The extreme variability in the site-specific risk estimates is largely a consequence of the small number of excess cases. The adjusted estimates provide a useful perspective on variation in the actual risks. However, additional work on interpretation of the adjusted estimates, extension of the methods used in describing effect modification, and making more use of prior knowledge is needed to make these methods useful. PMID:21128806

  18. CSR: Bridging business and development for sustainability : a case study of CSR implementation at coffee houses as enabler for sustainable development and livelihood among small-scale produsers

    OpenAIRE

    Melbye, Janne Gillgren

    2010-01-01

    A prerequisite for achievement of sustainable development is economical growth (NorwegianGovernment, 2008-2009). Today an increasing number of corporations in the Western world implement the concept of Corporate Social Responsibility (CSR) (NorwegianEmbassyMexico, 2010a; NorwegianGovernment, 2008-2009). Accountability theories suggests that CSR initiatives increases transparency and accountability of a company, which again increases its legitimacy (Bendell, 2000; Utting, 2005). CSR is makes ―...

  19. CSR v ČR – chtějí firmy celonárodní systém koordinace CSR?

    OpenAIRE

    Skřivan, Lukáš

    2014-01-01

    This bachelor thesis connects the concept of corporate social responsibility (CSR) with sustainable development. In general, it shows the theoretical essentials of CSR area. Based on own research among companies in the Czech republic, the thesis analyzes, in specific factors, what expectations companies had of implementing the CSR to business strategy. These expectations are then, by firms, compared to evaluations of positives in said specific factors. The results show, that expectations are ...

  20. CSR activities within service corporations : A case study about how four legal jurists and their service corporation conduct CSR activities with primary focus on SME law firms.

    OpenAIRE

    Kornmann, Jan; Adolfsson, Marcus

    2010-01-01

    Purpose: The purpose of this thesis is to interview four legal jurists in order to explore how they conduct CSR activities within their service corpora-tion, with primary focus on SME law firms. Background: A current issue to address concerning the conduct of business these days is CSR activities. Although, the previous research concerning CSR activities and the service sector is limited. Theoretical Framework: The theoretical framework is divided into four parts; a general part concerning th...

  1. Reflexive regulation of CSR to promote sustainablility:understanding EU public-private regulation on CSR thourgh the case of human rights

    OpenAIRE

    Buhmann, Karin

    2010-01-01

    This article discusses Corporate Social Responsibility (CSR) from the perspective of governmental regulation as a measure to promote public policy interests through public-private regulation intended to influence firms’ self-regulation. Presenting a ‘government case’ for CSR, the connection between climate change and environmental sustainability, and social, economic and other human rights lend human rights as part of CSR a potential for meeting some environmental and climate concerns and han...

  2. Variation in the Group B Streptococcus CsrRS Regulon and Effects on Pathogenicity▿ †

    OpenAIRE

    Jiang, Sheng-Mei; Ishmael, Nadeeza; Hotopp, Julie Dunning; Puliti, Manuela; Tissi, Luciana; Kumar, Nikhil; Cieslewicz, Michael J.; Tettelin, Hervé; Wessels, Michael R.

    2008-01-01

    CsrRS (or CovRS) is a two-component regulatory system that controls expression of multiple virulence factors in the important human pathogen group B Streptococcus (GBS). We now report global gene expression studies in GBS strains 2603V/R and 515 and their isogenic csrR and csrS mutants. Together with data reported previously for strain NEM316, the results reveal a conserved 39-gene CsrRS regulon. In vitro phosphorylation-dependent binding of recombinant CsrR to promoter regions of both positi...

  3. Multinationals, CSR and partnerships in Central African conflict countries

    NARCIS (Netherlands)

    A. Kolk; F. Lenfant

    2013-01-01

    Attention has increased for the potential role of multinational enterprises (MNEs) in helping address conflict issues and/or furthering peace and reconciliation as part of their corporate social responsibility (CSR) policies. However, while existing literature emphasises the importance for MNEs to c

  4. Are CSR disclosures relevant for investors? Empirical evidence from Germany

    NARCIS (Netherlands)

    Verbeeten, F.H.M.; Gamerschlag, R.; Möller, K.

    2016-01-01

    Purpose – The purpose of this paper is to examine whether narrative corporate social responsibility (CSR) disclosures (the provision of textual information on companies’ environmental and social performance to external stakeholders) are associated with firm value in Germany. Design/methodology/appro

  5. Closing the Achievement Gap: Urban Schools. CSR Connection.

    Science.gov (United States)

    Porter, Kathleen; Soper, Stephanie

    This report reviews efforts to reform urban schools, focusing on initiatives in Tennessee and California as examples from which distric leaders may draw useful lessons. The report suggests that comprehensive school reform (CSR) offers promise to struggling urban schools by focusing on transforming the academic climate, school culture, and…

  6. Highly charged atomic physics at HIRFL-CSR

    International Nuclear Information System (INIS)

    HIRFL-CSR is a proposed electron cooling storage ring optimized to accelerate and store beams of highly charged heavy ions. Several possibilities for advanced atomic physics studies are discussed, such as studies of electron-ion, ion-atoms, photon-ion-electron interactions and high resolution spectroscopy

  7. Birthing histone mRNAs by CSR-1 section

    OpenAIRE

    Pasquinelli, Amy E.

    2012-01-01

    Histone pre-mRNAs undergo maturation through a mechanism distinct from all other RNA Pol II transcripts. In C. elegans, 3′-end processing of histone mRNAs depends on the RNAi pathway involving the Argonaute protein CSR-1.

  8. Opening the CSR Discourse for Critical Stakeholders in Social Media

    DEFF Research Database (Denmark)

    Etter, Michael

    This study examines how a contested fast food chain in the middle of on-going image transformation efforts opens the distorted discourse about CSR with a social media campaign and enables the interference of official corporate communication and stakeholder critique. The study examines how...

  9. AN INVESTIGATION OF CSR ORIENTATIONS AMONG GREEK UNIVERSITY STUDENTS

    OpenAIRE

    Robyn Walker; Charalambos Kanellopoulos; Maria Papanayiotou; Antonios Vitalis

    2003-01-01

    This paper presents the results of a survey of the corporate social responsibility (CSR) orientations of commerce students at the University of Piraeus. The study utilised the instrument developed by Aupperle (1982, cited in Aupperle, Carroll, & Hatfield, 1985) based on Carroll's (1979) social responsibility framework. Comparisons are made with the results of other surveys that have used the same method.

  10. Ownership Concentration and CSR Policy of European Multinational Enterprises

    NARCIS (Netherlands)

    Dam, Lammertjan; Scholtens, Bert

    2013-01-01

    This study investigates how ownership concentration in European multinational firms is associated with these firms' corporate social responsibility (CSR). We employ factor analysis on responsibility data from EIRiS and use a regression analysis. Using firm-level data for almost 700 European firms, w

  11. In Silico Identification and Experimental Characterization of Regulatory Elements Controlling the Expression of the Salmonella csrB and csrC Genes

    OpenAIRE

    Martínez, Luary C.; Martínez-Flores, Irma; Salgado, Heladia; Fernández-Mora, Marcos; Medina-Rivera, Alejandra; Puente, José L.; Collado-Vides, Julio; Bustamante, Víctor H.

    2014-01-01

    The small RNAs CsrB and CsrC of Salmonella indirectly control the expression of numerous genes encoding widespread cellular functions, including virulence. The expression of csrB and csrC genes, which are located in different chromosomal regions, is coordinated by positive transcriptional control mediated by the two-component regulatory system BarA/SirA. Here, we identified by computational analysis an 18-bp inverted repeat (IR) sequence located far upstream from the promoter of Salmonella en...

  12. SOCIAL PERFORMANCE ENHANCES FINANCIAL PERFORMANCE. BENEFITS FROM CSR

    Directory of Open Access Journals (Sweden)

    gazzola patrizia

    2012-07-01

    Full Text Available The research aims to show how Corporate Social Responsibility (CSR should not be considered a cost to bear as an economic social actor but an investment that will contribute to the competitiveness and growth of the firm. In the first part we consider capitalistic firm as systems for the creation of economic and financial value for their shareholders. We measure their performance by a system of monetary values. In the second part we do not limit our view to simply the shareholders, but we consider, instead a vast group of stakeholders because it is important not only to make profits, but also how companies make them . In these years characterized by the financial crisis, where many big companies went bankrupt, more and more companies are speaking about ethics and CSR. For a firm, acting socially responsible, means for example having fair compensations, promoting transparency and the respect of employees, neutralizing conflicts of interest, as well as taking care of the environment. CSR is today a topic for discussion not only for business people but also for politicians, media, researchers, NGOs and consumers. Growing awareness of CSR is evident in the growth of voluntary codes of corporate conduct, in the growth of companies that are using self-reporting on social and environmental practices, and in increasingly social and ethical investment funds. The public and governments of the world have been steadily increasing pressure on corporations to increase their CSR. Recently the European Commission has put forward a new, simpler definition of corporate social responsibility as “the responsibility of enterprises for their impacts on society” (European Commission 25/10/2011. Companies have realized that to increase their market share or keep their market share, they must adopt CSR, but the synergy between social performance and financial performance is not automatic; rather it is the result of efforts that combine managerial

  13. The global regulatory system Csr senses glucose through the phosphoenolpyruvate: carbohydrate phosphotransferase system.

    Science.gov (United States)

    Pérez-Morales, Deyanira; Bustamante, Víctor H

    2016-02-01

    A novel connection between two regulatory systems controlling crucial biological processes in bacteria, the carbon storage regulator (Csr) system and the glucose-specific phosphotransferase system (PTS), is reported by Leng et al. in this issue. This involves the interaction of unphosphorylated EIIA(Glc), a component of the glucose-specific PTS, with the CsrD protein, which accelerates the decay of the CsrB and CsrC small RNAs via RNase E in Escherichia coli. As unphosphorylated EIIA(G) (lc) is generated in the presence of glucose, the PTS thus acts as a sensor of glucose for the Csr system. Interestingly, another pathway can operate for communication between the Csr system and the glucose-specific PTS. The absence of glucose generates phosphorylated EIIA(Glc) , which activates the enzyme adenylate cyclase to produce cyclic adenosine monophosphate (cAMP) that, in turn, binds to the regulator cAMP receptor protein (CRP). Leng et al. show that the complex cAMP-CRP modestly reduces CsrB decay independently of CsrD. On the other hand, a previous study indicates that the complex cAMP-CRP positively regulates the transcription of CsrB and CsrC in Salmonella enterica. Therefore, EIIA(G) (lc) could work as a molecular switch that regulates the activity of the Csr system, in response to its phosphorylation state determined by the presence or absence of glucose, in order to control gene expression. PMID:26593223

  14. The Integration of Corporate Social Responsibility (CSR) Initiatives into Business Activities

    DEFF Research Database (Denmark)

    Knudsen, Jette Steen

    While proponents of Corporate Social Responsibility (CSR) have suggested that CSR initiatives should be integrated into mainstream business activities as ‘strategic CSR’ or ‘shared value’, research is lacking that explores how CSR initiatives are integrated in companies. This article compares CSR...... initiatives to human resource management (HRM) initiatives, which have a longer tradition of being integrated into company strategy. The focus is on gender diversity and CSR initiatives in a US multinational corporation (MNC). The MNC sees gender diversity as an integral part of business activities....... In contrast, the MNC lacks a clear justification for the much broader CSR agenda, CSR activities seem not to reflect an overall set of values or purpose, integration into business activities is unclear, and targets are lacking....

  15. CSR Fields: Direct Numerical Solution of the Maxwell's Equation

    International Nuclear Information System (INIS)

    We discuss the properties of the coherent electromagnetic fields of a very short, ultra-relativistic bunch in a rectangular vacuum chamber inside a bending magnet. The analysis is based on the results of a direct numerical solution of Maxwell's equations together with Newton's equations. We use a new dispersion-free time-domain algorithm which employs a more efficient use of finite element mesh techniques and hence produces self-consistent and stable solutions for very short bunches. We investigate the fine structure of the CSR fields including coherent edge radiation. This approach should be useful in the study of existing and future concepts of particle accelerators and ultrafast coherent light sources. The coherent synchrotron radiation (CSR) fields have a strong action on the beam dynamics of very short bunches, which are moving in the bends of all kinds of magnetic elements. They are responsible for additional energy loss and energy spread; micro bunching and beam emittance growth. These fields may bound the efficiency of damping rings, electron-positron colliders and ultrafast coherent light sources, where high peak currents and very short bunches are envisioned. This is relevant to most high-brightness beam applications. On the other hand these fields together with transition radiation fields can be used for beam diagnostics or even as a powerful resource of THz radiation. A history of the study of CSR and a good collection of references can be found in (1). Electromagnetic theory suggests several methods on how to calculate CSR fields. The most popular method is to use Lienard-Wiechert potentials. Other approach is to solve numerically the approximate equations, which are a Schrodinger type equation. These numerical methods are described in (2). We suggest that a direct solution of Maxwell's equations together with Newton's equations can describe the detailed structure of the CSR fields (3).

  16. HPV genotyping and site of viral integration in cervical cancers in Indian women.

    Directory of Open Access Journals (Sweden)

    Poulami Das

    Full Text Available Persistent HPV infection plays a major role in cervical cancer. This study was undertaken to identify HPV types in a cohort of Indian women with locally advanced cervical cancer as well as to determine the physical state and/or site of viral integration in the host genome. Pretreatment biopsies (n = 270 from patients were screened for HPV infection by a high throughput HPV genotyping assay based on luminex xMAP technology as well as MY09/11 PCR and SPF1/2 PCR. Overall HPV positivity was observed to be 95%, with HPV16 being most common (63% followed by infection with HPV18. Integration status of the virus was identified using Amplification of Papillomavirus Oncogene Transcripts (APOT assay in a subset of samples positive for HPV16 and/or HPV18 (n = 86 and with an adequate follow-up. The data was correlated with clinical outcome of the patients. Integration of the viral genome was observed in 79% of the cases and a preference for integration into the chromosomal loci 1p, 3q, 6q, 11q, 13q and 20q was seen. Clinical data revealed that the physical state of the virus (integrated or episomal could be an important prognostic marker for cervical cancer.

  17. Cancer in neck nodes with unknown primary site: Role of mucosal radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Harper, C.S.; Mendenhall, W.M.; Parsons, J.T.; Stringer, S.P.; Cassisi, N.J.; Million, R.R. (Royal Perth Hospital (Australia))

    1990-11-01

    Sixty-nine patients with metastatic squamous cell carcinoma in neck nodes with an unknown primary lesion were treated with curative intent between October 1964 and December 1986. Sixty-five patients received radiotherapy to the neck and at least part of the mucosa of the head and neck, whereas 4 patients received treatment to the neck only. Mucosal doses were approximately 5,000 cGy-6,000 cGy at 170 cGy-180 cGy per fraction. Eight patients (12%) subsequently developed mucosal site failures, a figure that did not differ significantly from the incidence of a second metachronous head and neck cancer following definitive irradiation in a series of 393 patients with lesions of the supraglottic larynx, pharyngeal wall, pyriform sinus, or tonsillar area. This suggests that radiotherapy was highly effective in preventing the appearance of cancer at the unknown primary site from which the neck metastasis arose. Absolute and cause-specific 5-year survival rates were 48% and 66%, respectively.

  18. Site-Dependent Differences in Clinical, Pathohistological, and Molecular Parameters in Metastatic Colon Cancer

    Directory of Open Access Journals (Sweden)

    Christoph Wilmanns, Sandra Steinhauer, Joachim Grossmann, Günther Ruf

    2009-01-01

    Full Text Available The purpose was to develop a metastatic score specific to the hepatic and peritoneal site in colorectal cancer patients from clinical, pathohistological and molecular markers potentially reflecting oncogenic activation (OA or epithelial-mesenchymal transition (EMT, where OA may reflect an activation and EMT the functional loss of certain genes. The primary tumour stage (OA, EMT, lymphonodal stage (OA, the presence of a lymphangiosis carcinomatosa (OA, histological grade (OA, EMT, and immunoblot extraction of E-cadherin (OA, EMT were differentially rated with zero to one or two points due to their potential contribution to each process and the resulting scores were validated in 27 colorectal cancer patients (three patients with pre-malignant adenomas, 16 with primaries and two with local recurrencies, three of which were metastatic to the peritoneum, six metastatic to the liver and two metastatic to both, the liver and the peritoneum, and five with hepatic secondaries, one of which at histology was metastatic to the peritoneum too. As a single parameter only the N-stage significantly contributed to OA (p<0.05. Median OA and EMT scores, however, were 3.5 and 2 in the case of primaries without further spread, 5 and 4 in those nodal positive, 5 and 4 in the case of peritoneal implants, 6 and 2 in the case of liver metastases, and 6.5 and 3 in the case of a simultaneous hepatic and peritoneal spread, respectively. These differences were significant when scores from patients with and without liver metastases (OA, p<0.002 or with peritoneal implants and isolated hepatic spread (EMT, p<0.01 were compared. The results suggest a site-specific contribution of OA and EMT to tumour progression in human colon cancer.

  19. SNPing cancer in the bud: microRNA and microRNA-target site polymorphisms as diagnostic and prognostic biomarkers in cancer

    OpenAIRE

    Salzman, David W.; Weidhaas, Joanne B

    2012-01-01

    MicroRNAs are master regulators of gene expression and control many biological pathways such as cell growth, differentiation and apoptosis. Deregulation of microRNA expression and activity results in a myriad of diseases including cancer. Recently, several reports have indicated that single nucleotide polymorphisms (SNPs) in microRNAs and microRNA-target sites impact microRNA biology and associate with cancer risk, treatment response and outcome. In this review we will describe these findings...

  20. MODEL CORPORATE SOCIAL RESPONSIBILITY (CSR) PERUSAHAAN TAMBANG BATUBARA DI KABUPATEN LAHAT TERHADAP PEMBERDAYAAN MASYARAKAT BERBASIS KEARIFAN LOKAL

    OpenAIRE

    Antonius Suhadi; AR Febrian; Sri Turatmiyah

    2014-01-01

    Corporate Social Responsibility (CSR) is a corporate responsibility. The research intends to inves-tigate how CSR program is implemented, the role of local administrative, and CSR alternative model on the coal mining company in Lahat District. This normative and empiric research is aimed at finding out the implementation of local government role, and to find out the alternative model of CSR. The CSR implementation of PT BA and PT BAU as a mining company in the cooperation program includes ar...

  1. The Csr system regulates genome-wide mRNA stability and transcription and thus gene expression in Escherichia coli

    OpenAIRE

    Thomas Esquerré; Marie Bouvier; Catherine Turlan; Carpousis, Agamemnon J.; Laurence Girbal; Muriel Cocaign-Bousquet

    2016-01-01

    Bacterial adaptation requires large-scale regulation of gene expression. We have performed a genome-wide analysis of the Csr system, which regulates many important cellular functions. The Csr system is involved in post-transcriptional regulation, but a role in transcriptional regulation has also been suggested. Two proteins, an RNA-binding protein CsrA and an atypical signaling protein CsrD, participate in the Csr system. Genome-wide transcript stabilities and levels were compared in wildtype...

  2. Corporate Social Responsibility:A framework for analysing CSR heterogeneity through the case of Indonesian Palm Oil

    OpenAIRE

    Tanaya, Jimmy

    2013-01-01

    Corporate Social Responsibility (CSR) represents a recent manifestation of the shifting of Role of Business in Society (RBiS). This thesis aims to study the development of and negotiation of various RBiS among various governance actors as manifested in CSR practices. In so doing, it reveals the heterogeneity of CSR practices over time as a contrast to the rigid and simplistic delineation of CSR practices; the institutionalisation of CSR into business strategy that so far has been perceived as...

  3. CSR behavior and aging model for the Viton© Fluorelastomer O-rings in the 9975 shipping package

    Energy Technology Data Exchange (ETDEWEB)

    Mcwilliams, A. J. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Daugherty, W. L. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Skidmore, T. E. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-12-01

    The 9975 Type B shipping package is used within the DOE complex for shipping special nuclear materials. This package is re-certified annually in accordance with Safety Analysis Report for Packaging (SARP) requirements. The package is also used at the Savannah River Site as part of the long-term storage configuration of special nuclear materials. As such, the packages do not undergo annual recertification during storage, with uncertainty as to how long some of the package components will meet their functional requirements in the storage environment. The packages are currently approved for up to 15 years storage, and work continues to provide a technical basis to extend that period. This report describes efforts by the Savannah River National Laboratory (SRNL) to extend the service life estimate of Viton® GLT and GLT-S fluoroelastomer O-rings used in the 9975 shipping package. O-rings of both GLT and GLT-S compositions are undergoing accelerated aging at elevated temperature, and are periodically tested for compression stress relaxation (CSR) behavior. The CSR behavior of O-rings was evaluated at temperatures from 175 to 400 °F. These collective data were used to develop predictive models for extrapolation of CSR behavior to relevant service temperatures (< 156 °F). The predictive model developed from the CSR data conservatively indicates a service life of approximately 37 years for Viton GLT O-rings at the maximum effective service temperature of 156 °F. The estimated service life for Viton GLT-S O-rings is significantly longer.

  4. CSR behavior and aging model for the Viton© Fluorelastomer O-rings in the 9975 shipping package

    International Nuclear Information System (INIS)

    The 9975 Type B shipping package is used within the DOE complex for shipping special nuclear materials. This package is re-certified annually in accordance with Safety Analysis Report for Packaging (SARP) requirements. The package is also used at the Savannah River Site as part of the long-term storage configuration of special nuclear materials. As such, the packages do not undergo annual recertification during storage, with uncertainty as to how long some of the package components will meet their functional requirements in the storage environment. The packages are currently approved for up to 15 years storage, and work continues to provide a technical basis to extend that period. This report describes efforts by the Savannah River National Laboratory (SRNL) to extend the service life estimate of Viton® GLT and GLT-S fluoroelastomer O-rings used in the 9975 shipping package. O-rings of both GLT and GLT-S compositions are undergoing accelerated aging at elevated temperature, and are periodically tested for compression stress relaxation (CSR) behavior. The CSR behavior of O-rings was evaluated at temperatures from 175 to 400 °F. These collective data were used to develop predictive models for extrapolation of CSR behavior to relevant service temperatures (< 156 °F). The predictive model developed from the CSR data conservatively indicates a service life of approximately 37 years for Viton GLT O-rings at the maximum effective service temperature of 156 °F. The estimated service life for Viton GLT-S O-rings is significantly longer.

  5. CSR and CSR Reporting: Reporting as a way to create Socially Responsible Business

    Directory of Open Access Journals (Sweden)

    Fabio Andrés Bonilla Sanabria

    2011-12-01

    Full Text Available Admitting the theory of a company being a set of multiple interests, the first part of this article intends to give an overview of the Shareholder and Stockholders models in the Corporate Social Responsibility debate. The prevailing view in western Company Law (the cases of the UK and US are considered is that of the Shareholder Wealth Maximization model. For the author of the article, events such as the financial crisis showed that the financial conditions of companies giving its‘ extended effects should give way to calls for public accountability in company management. However there seems to be a deadlock given that the prevailing model favours shareholders.In this scenario the Reporting of Non-Financial Information is studied as a way to create socially responsible businesses. In addressing the reporting of non-financial information, the article provides a state of affairs regarding reporting and considers specific examples of disclosure of corporate information. The CSR battle has been transferred to the reporting of non-financial information but in this field there are many difficulties unresolved and challenges ahead.

  6. Pathological Predictors for Site of Local Recurrence After Radiotherapy for Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Chopra, Supriya [Department of Radiation Oncology, University of Toronto, Toronto (Canada); Princess Margaret Hospital, University Health Network, Toronto (Canada); Toi, Ants [Princess Margaret Hospital, University Health Network, Toronto (Canada); Department of Medical Imaging, University of Toronto, Toronto (Canada); Taback, Nathan [Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto (Canada); Evans, Andrew [Princess Margaret Hospital, University Health Network, Toronto (Canada); Department of Pathology, University of Toronto, Toronto (Canada); Haider, Masoom A. [Princess Margaret Hospital, University Health Network, Toronto (Canada); Department of Medical Imaging, University of Toronto, Toronto (Canada); Sunnybrook Health Sciences Center, Toronto (Canada); Milosevic, Michael; Bristow, Robert G.; Chung, Peter; Bayley, Andrew [Department of Radiation Oncology, University of Toronto, Toronto (Canada); Princess Margaret Hospital, University Health Network, Toronto (Canada); Morton, Gerard; Vesprini, Danny [Department of Radiation Oncology, University of Toronto, Toronto (Canada); Odette Cancer Center, Sunnybrook Health Sciences Center, Toronto (Canada); Warde, Padraig; Catton, Charles [Department of Radiation Oncology, University of Toronto, Toronto (Canada); Princess Margaret Hospital, University Health Network, Toronto (Canada); Menard, Cynthia, E-mail: Cynthia.Menard@rmp.uhn.on.ca [Department of Radiation Oncology, University of Toronto, Toronto (Canada); Princess Margaret Hospital, University Health Network, Toronto (Canada)

    2012-03-01

    Purpose: Rational design of targeted radiotherapy (RT) in prostate cancer (Pca) hinges on a better understanding of spatial patterns of recurrence. We sought to identify pathological factors predictive for site of local recurrence (LR) after external beam RT. Methods and Materials: Prospective databases were reviewed to identify men with LR after RT from 1997 through 2009. Patients with biochemical failure and biopsy-confirmed Pca more than 2 years after RT were evaluated. Prediction for site of recurrence based on the following pretreatment factors was determined on independent and cluster-sextant basis: presence of malignancy, dominant vs. nondominant percentage core length (PCL) involvement, PCL {>=} or <40%, and Gleason score. Sites of dominant PCL were defined as sextants with peak PCL involvement minus 10%, and >5% for each patient. Results: Forty-one patients with low-intermediate risk Pca constituted the study cohort. Median time to biopsy after RT was 51 months (range, 24-145). Of 246 sextants, 74 were involved with tumor at baseline. When sextants are treated as independent observations the presence of malignancy (77% vs. 22%, p = 0.0001), dominant PCL (90% vs. 46%, p = 0.0001), and PCL {>=}40% (89% vs. 68 %, p = 0.04) were found to be significant predictors for LR, although PCL {>=}40% did not retain statistical significance if sextants were considered correlated. The vast majority of patients (95%) recurred at the original site of dominant PCL or PCL {>=}40%, and 44% also recurred in regions of nondominant PCL <40% (n = 8) and/or benign sampling (n = 14) at baseline. Conclusions: LR after RT predominantly occurs in regions bearing higher histological tumor burden but are not isolated to these sites. Our data highlights the value of spatially resolved baseline pathological sampling and may assist in the design of clinical trials tailoring RT dose prescriptions to subregions of the prostate gland.

  7. Post-transcriptional regulation on a global scale: form and function of Csr/Rsm systems.

    Science.gov (United States)

    Romeo, Tony; Vakulskas, Christopher A; Babitzke, Paul

    2013-02-01

    Originally described as a repressor of gene expression in the stationary phase of growth, CsrA (RsmA) regulates primary and secondary metabolic pathways, biofilm formation, motility, virulence circuitry of pathogens, quorum sensing and stress response systems by binding to conserved sequences in its target mRNAs and altering their translation and/or turnover. While the binding of CsrA to RNA is understood at an atomic level, new mechanisms of gene activation and repression by this protein are still emerging. In the γ-proteobacteria, small non-coding RNAs (sRNAs) use molecular mimicry to sequester multiple CsrA dimers away from mRNA. In contrast, the FliW protein of Bacillus subtilis inhibits CsrA activity by binding to this protein, thereby establishing a checkpoint in flagellum morphogenesis. Turnover of CsrB and CsrC sRNAs in Escherichia coli requires a specificity protein of the GGDEF-EAL domain superfamily, CsrD, in addition to the housekeeping nucleases RNase E and PNPase. The Csr system of E. coli contains extensive autoregulatory circuitry, which governs the expression and activity of CsrA. Interaction of the Csr system with transcriptional regulatory networks results in a variety of complex response patterns. This minireview will highlight basic principles and new insights into the workings of these complex eubacterial regulatory systems. PMID:22672726

  8. Szanse i ograniczenia stosowania strategii CSR w polskich przedsiêbiorstwach/The Chances and the Limitation of Applying the CSR Strategy in Polish Enterprises

    OpenAIRE

    Codogni, Iwona

    2012-01-01

    The topic of the article is the perspectives of CSR in Polish companies. The article contains the definition of corporate social responsibility, the state and dynamics of ethical reporting and the factors that can influence the dynamics of CSR in Poland – both in a favourable and adverse way.

  9. Using a stem cell-based signature to guide therapeutic selection in cancer.

    Science.gov (United States)

    Shats, Igor; Gatza, Michael L; Chang, Jeffrey T; Mori, Seiichi; Wang, Jialiang; Rich, Jeremy; Nevins, Joseph R

    2011-03-01

    Given the very substantial heterogeneity of most human cancers, it is likely that most cancer therapeutics will be active in only a small fraction of any population of patients. As such, the development of new therapeutics, coupled with methods to match a therapy with the individual patient, will be critical to achieving significant gains in disease outcome. One such opportunity is the use of expression signatures to identify key oncogenic phenotypes that can serve not only as biomarkers but also as a means of identifying therapeutic compounds that might specifically target these phenotypes. Given the potential importance of targeting tumors exhibiting a stem-like phenotype, we have developed an expression signature that reflects common biological aspects of various stem-like characteristics. The consensus stemness ranking (CSR) signature is upregulated in cancer stem cell-enriched samples at advanced tumor stages and is associated with poor prognosis in multiple cancer types. Using two independent computational approaches we utilized the CSR signature to identify clinically useful compounds that could target the CSR phenotype. In vitro assays confirmed selectivity of several predicted compounds including topoisomerase inhibitors and resveratrol towards breast cancer cell lines that exhibit a high-CSR phenotype. Importantly, the CSR signature could predict clinical response of breast cancer patients to a neoadjuvant regimen that included a CSR-specific agent. Collectively, these results suggest therapeutic opportunities to target the CSR phenotype in a relevant cohort of cancer patients. PMID:21169407

  10. Evaluation the susceptibility of five polymorphisms in microRNA-binding sites to female breast cancer risk in Chinese population.

    Science.gov (United States)

    He, Bang-Shun; Pan, Yu-Qin; Lin, Kang; Ying, Hou-Qun; Wang, Feng; Deng, Qi-Wen; Sun, Hui-Ling; Gao, Tian-Yi; Wang, Shu-Kui

    2015-11-15

    Polymorphisms in microRNA (miRNA) binding site have been widely discussed to be associated with cancer risk; however, the associations were unclear in Chinese population. To investigate the associations of five polymorphisms (rs11097457, rs1434536, rs1970801, rs1044129, rs11169571) in miRNA binding sites with breast cancer risk, a total of 435 female patients with breast cancer and 439 age- and gender-matched tumor-free individuals were enrolled in this case-control study. Sequenom MassARRAY was applied to detect the polymorphisms, and the immunohistochemistry assay was used to measure the expression of estrogen receptor (ER) and progesterone receptor (PR) and CerbB-2. The data showed that these polymorphisms were not associated with breast cancer risk or clinical characters of breast cancer in all participants and sub-group with the exception that, in the sub-group of women with their first menstruation after 14 years old, those who carried rs1970801 T allele (genotype TT/GT) were associated with decreased breast cancer risk. In short, this case-control study provided the evidence that women with their first menstruation after 14 years old and carried rs1970801 T allele (genotype TT/GT) were associated with decreased breast cancer risk.

  11. Trends in head and neck cancer incidence in Denmark, 1978-2007: Focus on human papillomavirus associated sites

    DEFF Research Database (Denmark)

    Blomberg, Maria; Nielsen, Ann; Plum, Christian Edinger Munk;

    2011-01-01

    and the overall incidence increased throughout the period. Significantly increasing incidence rates were notably seen for tumors in the oral cavity (2.2% per year), tonsils (4.8% per year), oropharynx (3.5% per year) and hypopharynx (4.4% per year). A significantly decreasing incidence of lip cancer was observed...... among men (-5.0% per year). Cancers at HPV-associated sites (n = 3650) showed strongly increasing incidence rates, primarily in individuals years. In contrast, HNCs at sites not related to HPV infection showed a significant decrease (in men) or virtually no change in incidence (in women). Our...

  12. [Lung Cancer Incidentally Detected by a Subcutaneous Nodule at the Drainage Site for Pneumothorax].

    Science.gov (United States)

    Okamoto, Jumpei; Matsumoto, Isao; Saito, Daisuke; Yoshida, Shuhei; Takada, Munehisa; Tamura, Masaya; Takemura, Hirofumi; Ikeda, Hiroko

    2016-08-01

    A 43-year-old male patient underwent thoracic drainage for the treatment of right pneumothorax. After 6 months, the patient visited our department because of a subcutaneous nodule found at the drainage site. Chest computed tomography revealed a mass lesion associated with a cavity in the right upper lobe of the lung and a subcutaneous nodule. Surgical resection was performed and both the pulmonary lesion and subcutaneous nodule were found to be adenocarcinoma. Although immunohistochemical analysis suggested that the pulmonary lesion was primary lung cancer, there were neither intrathoracic exposure of the tumor nor tumor cells in the pleural lavage cytology. The expression pattern of subcutaneous tumor in the right chest was slightly different from that of the lung lesion by immunohistochemistry. Therefore, it was difficult to determine whether this subcutaneous nodule was a tumor implantation through the drainage procedure or subcutaneous metastasis from the primary tumor. PMID:27476564

  13. Stakeholder Models for Social and Mobile Media CSR Projects

    DEFF Research Database (Denmark)

    Kampf, Constance Elizabeth

    2014-01-01

    businesses to reduce their ecological footprint in immediate and concrete ways, 2) define consumer point of purchase information sources about product goodness for health, community and the environment, or 3) to push their agendas for using corporate resources for aid purposes. These consumers organize...... to engage with business about Corporate Social Responsibility (CSR). Second, it discusses how this technology calls for an expansion of our understanding of how to interact with stakeholders. This includes moving from a communication-focused perspective to an engagement perspective, meaning that consumers...... now have the ability to engage with knowledge resources related to CSR made available through innovative uses of smartphone and social media technology. In these cases of consumer initiated sustainability-on-the go—the Good Guide, CarrotMob and Colalife— organizations founded by activist individuals...

  14. CSR Communication Strategies for Organizational Legitimacy in Social Media

    DEFF Research Database (Denmark)

    Colleoni, Elanor

    2013-01-01

    Purpose – Organization legitimacy is a general reflection of the relationship between an organization and its environment. By adopting an institutional approach and defining moral legitimacy as “a positive normative evaluation of the organization and its activities”, the goal of this paper...... is to investigate which corporate communication strategy adopted in online social media is more effective to create convergence between corporations' corporate social responsibility (CSR) agenda and stakeholders' social expectations, and thereby, to increase corporate legitimacy. Design/methodology/approach – Using...... the entire Twitter social graph, a network analysis was carried out to study the structural properties of the CSR community, such as the level of reciprocity, and advanced data mining techniques, i.e. topic and sentiment analysis, were carried out to investigate the communication dynamics. Findings...

  15. CSR studies for transfer line-2 at CTF3, CERN

    International Nuclear Information System (INIS)

    A transfer line with ability to compress the electron beam bunch length has been designed for CTF3 project at CERN. This line compresses bunch length from 8.3 ps to 1.5 ps with a wide tuning range of longitudinal dispersion R56 from -0.25 m to +0.25 m. In entire range of tuning second order longitudinal dispersion T566 is suppressed and transverse beam emittance dilution is kept below ∼ 10%. But at shorter bunch length, the emitted synchrotron radiation becomes coherent and thus can increase the bunch length and can dilute the transverse emittance. A study is carried out to quantify the effect of CSR on bunch length and emittance in entire range of tuning for this line and no any major detrimental effects of CSR are seen. (author)

  16. Optimization of the HIRFL-CSR cluster target

    International Nuclear Information System (INIS)

    A new gas delivery system is designed and installed for HIRFL-CSR cluster target. The original blocked nozzle is replaced by a new one with the throat diameter of 0.12mm. New test of hydrogen and argon gases are performed. The stable jets can be obtained for these two operation gases. The attenuation of the jet caused by the collision with residual gas is studied. The maximum achievable H2 target density is 1.75 x 1013 atoms/cm3 with a target thickness of 6.3 x 1012 atoms/cm2 for HIRFL-CSR cluster target. The running stability of the cluster source is tested both for hydrogen and argon. The operation parameters for obtaining hydrogen jet are optimized. The results of long time running for H2 and Ar cluster jets look promising. The jet intensity has no essential change during the test for H2 and Ar. (authors)

  17. Development of Power Supply for HIRFL-CSR Dipole Magnet

    International Nuclear Information System (INIS)

    The HIRFL-CSR dipole magnet power supply was studied. A novel scheme for designing of the synchrotron dipole magnet power supply based on the phase-controlled thyristor rectifying technology and the IGBT pulse-width modulation (PWM) converting technology was presented. After analyzing and simulating the working principle of this scheme, one complete set of prototype power supply was designed and manufactured. Through long-time on-the-spot running and testing to the prototype power supply, the current stability is -5/8 h, the tracking accuracy is -4 and the current ripple -5. The experimental results show that this scheme can satisfy the technical requirements and indexes of the HIRFL-CSR dipole magnet to the power supply.(authors)

  18. Improved design of HIRFL-CSR EVME bus controller

    International Nuclear Information System (INIS)

    The EVME bus controller which is a key component of the HIRFL-CSR control system was improved. Besides reconfiguring the embedded Linux, a utility program was developed for data exchange between the controller and the database. The bus controller is based on ARM920T(ARM9) micro processor which is BGA packaged. The bus controller has the universal interface of VGA display, keyboard, and mouse. The backboard interface logic is programmed in an in-system configurable FPGA device. The bus can drive high current up to 64 mA, with the flexibility of the programmable signal definitions. All the improved performance helped the EVME bus controller play a crucial role in HIRFL-CSR control system. (authors)

  19. An untuned MA-loaded cavity for HIRFL-CSR

    International Nuclear Information System (INIS)

    In order to realize high energy density physics and plasma physics research at HIRFL-CSR, a magnetic alloy (MA)-loaded cavity has been studied. According to the theoretical calculation and simulation for the MA-loaded cavity, we achieved a better result. The MA-loaded cavity had a higher μQf value, with a higher shunt impedance and a higher accelerating gradient. The accelerating gradient was about 95 kV/m at 1.8003 MHz, 130 kV/m at 0.9000 MHz. Compared with the ferrite-loaded cavities that are used at HIRFL-CSR, with about 10 kV/m accelerating gradient, the MA-loaded cavity obviously has an advantage. The results of the theoretical calculation and the simulation, which meet the design requirements are in good agreement. (authors)

  20. Beam kicker control system for CSR project in Lanzhou

    International Nuclear Information System (INIS)

    The beam kicker system is a key part for beam extraction and injection in ring-like accelerator, which works under high voltage and huge current. This paper introduces the kicker control system based on ARM+DSP+FPGA for CSR project in Lanzhou, which has nanosecond timing precision. ARM mainly completes the control signals with the network communication, and the time control precision for the beam kicker system is performed mainly by FPGA and DSP. The sequence control signals through the optic fiber transmission, synchronous to kicker power supply the voltage to assign uses the signal isolators and ferrites to suppress the disturbance pulses. Scene test has proved that this system can meet beam kicker control's request and work safely and stably. The control system has extracted and injected the CSR beam successfully in October 2007. (authors)

  1. The collectivity in CSR 129Xe + 129Xe collisions

    International Nuclear Information System (INIS)

    The Heavy Ion Research Facility in Lanzhou (HIRFL) – Cooler Storage Ring (CSR), which can gather few hundreds MeV/nucleon for heavy ion beam energy in the external-target experiments, could make a significant contribution in studying the property of dense matter. By using a Relativistic Transport Model(ART1.0), we study the collectivity of identified hadrons in 129Xe + 129Xe collisions in CSR energy regions. Our investigation indicates that the anisotropic flow reaches its extremum around 500 MeV/nucleon of beam energy. The system size and EOS dependence on anisotropic flow show that directed flow is very sensitive to the equation of state. (author)

  2. HIRFL status and HIRFL-CSR project in Lanzhou

    International Nuclear Information System (INIS)

    HIRFL-CSR, a new accelerator project planned at the Heavy Ion Research Facility in Lanzhou (HIRFL), is a multipurpose Cooling Storage Ring system which consists of a main ring (CSRm) and an experimental ring (CSRe). The two existing cyclotrons SFC (K = 69) and SSC (K = 450) of the HIRFL will be used as its injector system. The heavy ion beams from the HIRFL will be accumulated, cooled and accelerated in the main ring, and then extracted to produce radioactive ion beams (RIB) or highly charged heavy ions. the secondary beams (RIB or highly charged ions) can then be accepted by the experimental ring for internal-target experiments. In this paper the status of the HIRFL and the details of the HIRFL-CSR project will be reported. (author)

  3. Beam spill structure feedback test in HIRFL-CSR

    International Nuclear Information System (INIS)

    HIRFL-CSR is the post-acceleration system of the Heavy Ion Research Facility in Lanzhou and is composed of a double cooling storage ring and a radioactive beam line. The slow extraction beam from HIRFL-CSR is used in nuclear physics experiments and heavy ion therapy. 50 Hz ripple and harmonics are observed in beam spill. To improve the spill structure, the first set of control system consisting of fast Q-magnet and feedback device based FPGA is developed and installed in 2010. Spill structure feedback testing has also started. It is shown that the feedback structure has improved the spill structure, the 50 Hz ripple and its harmonics have been reduced

  4. HIRFL-CSR commissioning in 2006 and 2007

    Institute of Scientific and Technical Information of China (English)

    XIA Jia-Wen; YUAN You-Jin; LIU Yong; YANG Jian-Cheng; XU Hu-Shan; XIAO Guo-Qing; YANG Xiao-Dong; ZHANG Wei; GAO Da-Qing; ZHOU Zhong-Zu; MAO Rui-Shi; MAO Li-Jun; HE Yuan; XU Zhe; YANG Ya-Qing; XIAO Chen; YIN Da-Yu; ZHAO Tie-Cheng; WU Jun-Xia; LI Guo-Hong; LI Jie; LI Peng; LI Ke; HU Zheng-Guo

    2009-01-01

    HIRFL-CSR,a flew heavy ion cooler-storage-ring system at IMP,had been in commissioning since the beginning of 2006.In the two years of 2006 and 2007 the CSR commissioning was finished,including the stripping injection(STI),electron-cooling with hollow electron beam,C-beam stacking with the combination of STI and e-cooling,the wide energy-range synchrotron ramping from 7 MeV/u to 1000 MeV/u by changing the RF harmonic-number at mid-energy,the multiple multi-turn injection(MMI),the beam accumulation with MMI and e-cooling for heavy-ion beams of Ar,Kr and Xe,the fast extraction from CSRm and single-turn injection to CSRe,beam stacking in CSRe and the RIBs mass-spectrometer test with the isochronous mode in CSRe by using the time-of-flight method.

  5. How Well are Water Companies Engaged in CSR?

    DEFF Research Database (Denmark)

    Lauesen, Linne Marie

    2014-01-01

    Purpose – The purpose of this paper is to investigate how well water companies in four different nationalities and political cultures are engaged in the CSR discourse. This question is relevant after more than 20 years of privatization of the public administration's bureaucracy and its adoption...... of management styles, behaviours and thinking from the private business sphere. This paper seeks to critically examine how water companies take part in the CSR discourse, by which institutional mechanisms this managerial “thinking” in terms of institutional “logics” has come about, and which adopted “meanings......” lie behind. Design/methodology/approach – The paper shows a qualitatively, ethnographic investigation and discourse analysis of privatized water companies from four different political and market economy nations; small- and medium-sized water companies from the social-democratic state of Denmark...

  6. Status and Assessments of CSR GRACE Level-2 Data Products

    Science.gov (United States)

    Bettadpur, Srinivas; Kang, Zhigui; Nagel, Peter; Pastor, Rick; Poole, Steve; Ries, John; Save, Himanshu

    2015-04-01

    The joint NASA/DLR GRACE mission has successfully operated for more than 13 years, and has provided a remarkable record of global mass flux due to a large variety of geophysical and climate processes at various spatio-temporal scales. The University of Texas Center for Space Research (CSR) hosts the mission PI, and is responsible for delivery of operational (presently denoted as Release-05 or RL05) gravity field data products. In addition, CSR generates and distributes a variety of other gravity field data products, including products generated from the use of satellite laser ranging data. This poster will provide an overview of all these data products, their relative quality, potential applications, and future plans for their development and delivery.

  7. Pathological Predictors for Site of Local Recurrence After Radiotherapy for Prostate Cancer

    International Nuclear Information System (INIS)

    Purpose: Rational design of targeted radiotherapy (RT) in prostate cancer (Pca) hinges on a better understanding of spatial patterns of recurrence. We sought to identify pathological factors predictive for site of local recurrence (LR) after external beam RT. Methods and Materials: Prospective databases were reviewed to identify men with LR after RT from 1997 through 2009. Patients with biochemical failure and biopsy-confirmed Pca more than 2 years after RT were evaluated. Prediction for site of recurrence based on the following pretreatment factors was determined on independent and cluster-sextant basis: presence of malignancy, dominant vs. nondominant percentage core length (PCL) involvement, PCL ≥ or 5% for each patient. Results: Forty-one patients with low-intermediate risk Pca constituted the study cohort. Median time to biopsy after RT was 51 months (range, 24–145). Of 246 sextants, 74 were involved with tumor at baseline. When sextants are treated as independent observations the presence of malignancy (77% vs. 22%, p = 0.0001), dominant PCL (90% vs. 46%, p = 0.0001), and PCL ≥40% (89% vs. 68 %, p = 0.04) were found to be significant predictors for LR, although PCL ≥40% did not retain statistical significance if sextants were considered correlated. The vast majority of patients (95%) recurred at the original site of dominant PCL or PCL ≥40%, and 44% also recurred in regions of nondominant PCL <40% (n = 8) and/or benign sampling (n = 14) at baseline. Conclusions: LR after RT predominantly occurs in regions bearing higher histological tumor burden but are not isolated to these sites. Our data highlights the value of spatially resolved baseline pathological sampling and may assist in the design of clinical trials tailoring RT dose prescriptions to subregions of the prostate gland.

  8. Development of Corporate Social Responsibility (CSR) in India

    OpenAIRE

    Ravi Shankar; Leslie Chadwick; Shahzad Ghafoor; Farooq Khan

    2011-01-01

    The interest in Corporate Social Responsibility (CSR), which recognizes thatcompanies have obligations that extend beyond short-run profit maximization toinclude notions of social and environmental concern, has increased considerably inrecent decades. The globalization of the world economy and the related tradeliberalization has brought forward a discussion of the importance of business as anactor in the development of society. The aim of this research is to analyse theeffectiveness of the CS...

  9. CSR Implementation and Concept at Unilever Pakistan : The Stakeholder Perspective

    OpenAIRE

    Hameed, Yasir

    2011-01-01

    This thesis studies the stakeholder dialogue of a multinational company known as Unilever Pakistan working in a developing economy like Pakistan. The study required deep understanding of the area that dictated research methodology be qualitative and exploratory. Thus, case study approach was adopted that satisfied the factors of reliability and trustworthiness. The theoretical model is based on the development of literature on sustainability marked by stating CSR and stakeholder thinking.The ...

  10. MNC reporting on CSR and conflict in Central Africa

    OpenAIRE

    Kolk, A.; Lenfant, F

    2010-01-01

    In recent years, corporate social responsibility (CSR) of Multinational Corporations (MNCs) in developing countries has received more attention. However, in this literature Africa is much less well represented than other regions, and existing studies about Africa have mainly focused on South Africa and Nigeria. This focus has resulted in scant research on other African countries where MNCs are located as well, and where their presence is notable. Settings largely unexplored include conflict-r...

  11. Management Role in CSR Practices : A Case of Telenor Pakistan

    OpenAIRE

    Khan, Muhammad Saleem; Naveed, Muhammad

    2012-01-01

    Corporate social responsibility strategy is an important issue for the contemporary debate on corporations in society when considering social and environmental impacts. Corporate Social Responsibility (CSR) has become more essential for every company across the world during last few decades. Therefore we see that the company image and reputation is completely dependent on the practical implementation of social responsibility strategies. This paper presents a theoretical review exhibits the re...

  12. How do Global Retail Companies utilize Corporate Social Responsibility (CSR)?

    OpenAIRE

    Jogie, Greg; Shukat, Ayaz

    2010-01-01

    Corporations around the world are today acknowledging more and more the need of long-term sustainability strategies integrated into their core businesses. This has led to the use of the Corporate Social Responsibility (CSR) framework. H&M and UNIQLO are no different. They are established global retailing companies and heavily affected by the consumers demand of a sustainable work process. The demands are often heard when news hits of problems in the supply-chain. This can be issues like u...

  13. Social Media and CSR - A Double-Edged Sword?

    OpenAIRE

    Caun, Stephanie. E.

    2010-01-01

    The emergence of social media has given people the ability to instantaneously communicate with thousands of people through an online platform. In a very short period of time, this new form of media has managed to creep into the business domain and has provided very real opportunities for CSR to develop. As a result of being such a new phenomenon, the academic literature surrounding social media is scarce. Therefore this study intends to give an extensive and balanced insight into the positive...

  14. Balancing profit maximization and social benefit within CSR projects

    OpenAIRE

    Nielsen, Louise Villadsen; Oustrup, Mads; Todbjerg, Ane; Clancy, Conor; Weimers, Ingrid

    2014-01-01

    This project investigates the perceived dichotomy between, profit maximisation and creating social benefit in CSR projects. The focus of the research is the multi-stakeholder project “Educa-tion Clarification in Practise” (ECP), run in collaboration between ISS, a Danish multinational company and Høje Taastrup Municipality. The focus of the project is to help young people under 30 into either job or education. The project investigates the different stakeholder logics within the project and th...

  15. Using sport for corporate social responsibility (CSR) in Finland

    OpenAIRE

    Hakala, Antti

    2015-01-01

    Companies are increasingly valued beyond their capability to maximize profits. Responsibility is one of the core issues in companies’ strategies nowadays. Meanwhile sport and health professionals are facing challenges: inactivity among people and costs in grassroots participation are growing. Therefore, the relationship between sport and business around the phenomenon called corporate social responsibility (CSR) has grown in importance. This study approaches the topic by answering the ma...

  16. A theoretical framework on CSR and urban development

    OpenAIRE

    Tsavdaridou, Maria; Metaxas, Theodore

    2015-01-01

    The role of enterprises in society is without doubt controversial nowadays due to the economic crisis. Although enterprises offer infrastructures, jobs, innovative solutions to local communities their primary goal is profit in order to be competitive and sustainable. This article examines the implementation of urban development projects under the CSR strategy and provides case studies of European enterprises that offered successful urban development projects in their local communities. There...

  17. THE GENDER DIFFERENCES EFFECTS ON CORPORATE SOCIAL RESPONSIBILITY (CSR)

    OpenAIRE

    LILIANA NICOLETA SIMIONESCU

    2015-01-01

    Corporate Social Responsibility (CSR) refers to company's activities through which they need to contribute to the society well-being. Companies which are socially responsible operate their business in such way stakeholders requirements are a meet as well as ethical, legal, economical and philanthropic expectations toward the society where companies operates. Moreover, businesses decisions and strategies should take into consideration and should act with more responsibility to shareholders, cu...

  18. Long-term CSR incentives at fashion chains in Sweden

    OpenAIRE

    Persson, Stefan

    2008-01-01

    In recent time the pressure on companies from groups like governments, regular citizens and media on taking its social responsibility has increased in rapid pace. This has led to increased interest from companies all over the world about social issues and the companies’ responsibility for these issues. In the more competitive environment were companies act today the use of corporate social responsibility (CSR) to differentiate itself against other company’s increases in importance. Together w...

  19. What relation exists between CSR and longevity of firms?

    OpenAIRE

    Sahut, Jean-Michel; Boulerne, Sandrine; MILI, MEDHI; Frédéric TEULON

    2013-01-01

    The relation between company longevity and its performance is undeniable; however the relationship between sustainability and performance remains the subject of multiple studies which seem to confirm a positive link. But what type of relationship exists between a firm’s longevity and sustainability management? In this paper, we demonstrate that the adoption of corporate social responsibility (CSR) principles explains this link. Therefore, sustainable development policies can create a rampart ...

  20. How logistics firms deal with and report on CSR expectations

    OpenAIRE

    Tong, Mengni; Moussa, Toni

    2012-01-01

    The concept of Corporate Social Responsibility (CSR) is not new; however, it hasstarted to gain more attention during the last fifteen years. During this period, logistics activities were structured to maximize profitability of all firms in the supply chain by including only economic costs while disregarding social and environmental costs. Since logistics firms play a vital role in international trade, and since they are one of the main types of firms that are facing pressure from various sha...

  1. Regulation of Bacterial Virulence by Csr (Rsm) Systems

    OpenAIRE

    Vakulskas, Christopher A.; Potts, Anastasia H.; Babitzke, Paul; Ahmer, Brian M. M.; Romeo, Tony

    2015-01-01

    Most bacterial pathogens have the remarkable ability to flourish in the external environment and in specialized host niches. This ability requires their metabolism, physiology, and virulence factors to be responsive to changes in their surroundings. It is no surprise that the underlying genetic circuitry that supports this adaptability is multilayered and exceedingly complex. Studies over the past 2 decades have established that the CsrA/RsmA proteins, global regulators of posttranscriptional...

  2. CSR in family business - ethnocentric meaning socially responsible?

    OpenAIRE

    Starnawska, Marzena; Popowska, Magdalena

    2015-01-01

    The aim of this paper is to provide framework and key issues relevant for research on social responsibility of family business. From providing two theoretical approaches towards social responsibility such as social capital concept commenting on the familiness as a family firm resource and capability; and the stakeholder theory we move to the state of the art of family business. Then, we discuss heterogeneity among family firms show how it can determine their CSR approach. We also refer to fam...

  3. Industry-specific effect of CSR initiatives: hotels and airlines

    OpenAIRE

    Casado-Díaz, Ana B.; Nicolau, Juan Luis; Ruiz Moreno, Manuel Felipe; Sellers Rubio, Ricardo

    2014-01-01

    Purpose – This study aims to examine the relationships between a firm's corporate social responsibility (CSR) activities and its performance and risk. The authors hypothesize that industry-level effects are highly determinant of the sign and magnitude of these relationships to establish a ranking of industries to identify the position of the most prominent tourism-related industries: hotels and airlines. Based on the cybernetic model of decision making and the heuristics thereof, shareholders...

  4. Does CSR attract us? Empirical evidence from Finnish Business Schools

    OpenAIRE

    Englund, Polina

    2014-01-01

    A talented, competent and motivated workforce is considered as a competitive advantage and an important contributor to a company's success in the market. Nowadays in the fight for the best human resources companies must meet the challenge in attracting and retaining freshly graduated business students. Some studies suggest that corporate social responsibility (CSR) may act as a signal of a company's values, working conditions and environment, enhance the corporate image and reputation of a co...

  5. Analýza CSR v energetickom sektore

    OpenAIRE

    Sýkora, Martin

    2011-01-01

    Master's Thesis deals with issue of corporate social responsibility in the energy industry. The work is divided into four chapters. In the first one author describes basic concepts related to this issue, focusing on the current understanding of corporate social responsibility from a global and European perspective and of course from the perspective of the Czech Republic. Criticism, barries and the future of CSR are not missing as well. The second and the third chapter is dedicated to a detail...

  6. Communicating CSR: Case Study of Japanese Food Industry

    OpenAIRE

    Kaori Takano

    2013-01-01

    This study examines how the Japanese food industry responded to the food education law of 2005 throughcorporate social responsibility (CSR) communication. No previous study has examined factory visits and foodeducation of the Japanese food industry as social responsibility activity in the light of the new food education lawin Japan. Corporate websites of all the food companies categorized in the food industry in Japan were examinedduring the period 2009 December to 2010 March: A total of 275 ...

  7. Proceedings CSR 2010 Workshop on High Productivity Computations

    CERN Document Server

    Ablayev, Farid; Vasiliev, Alexander; 10.4204/EPTCS.52

    2011-01-01

    This volume contains the proceedings of the Workshop on High Productivity Computations (HPC 2010) which took place on June 21-22 in Kazan, Russia. This workshop was held as a satellite workshop of the 5th International Computer Science Symposium in Russia (CSR 2010). HPC 2010 was intended to organize the discussions about high productivity computing means and models, including but not limited to high performance and quantum information processing.

  8. THE GENDER DIFFERENCES EFFECTS ON CORPORATE SOCIAL RESPONSIBILITY (CSR)

    OpenAIRE

    LILIANA NICOLETA SIMIONESCU

    2015-01-01

    Corporate Social Responsibility (CSR) refers to company's activities through which they need to contribute to the society well-being. Companies which are socially responsible operate their business in such way stakeholders requirements are a meet as well as ethical, legal, economical and philanthropic expectations toward the society where companies operates. Moreover, businesses decisions and strategies should take into consideration and should act with more responsibility to shar...

  9. THE YIN AND YANG OF CSR ETHICAL BRANDING

    Directory of Open Access Journals (Sweden)

    Ellisha Nasruddin

    2007-01-01

    Full Text Available Within the current discourse and the often overly-commercialized hyperbole of branding and positioning, there is a particular area that has not been given due attention. Yet, with the rapid changes and the multiple crises of present-day realities, a frequently neglected area, emerges as vitally imperative. The troubles can be seen in both large as well as small businesses within Malaysia. This article, thus, aims to bring back ethics, one of the management blind-spots, into the center stage of branding and organizational transformation. The objectives of this article are two-fold: (1 to build a discussion on the value and importance of ethical branding through CSR initiatives and (2 to present a CSR ethical branding (CSR-EB framework which delineates the content (yin and context (yang, comprising seven pillars: pillar of ethical core, pillar of inner stakeholders, pillar of products and services, pillar of outer stakeholders, pillar of cultural context, pillar of spatial context, and pillar of temporal context.

  10. Calculation of longitudinal CSR impedance in curved chamber

    International Nuclear Information System (INIS)

    Coherent synchrotron radiation (CSR) fields are generated when a bunched beam moves along a curved trajectory. A new code, named CSRZ, was developed using finite difference method to calculate the longitudinal CSR impedance for a beam moving along a curved chamber. The method adopted in our code was originated by T. Agoh and K. Yokoya [1]. It solves the parabolic equation in the frequency domain in a curvilinear coordinate system. In our studies, the chamber has uniform rectangular crosssection along the beam trajectory, which is the same as that in [1]. But the curvature of the beam trajectory is freed, and then we can investigate the CSR impedance of a single or a series of bending magnets. The calculation results indicate that the shielding effect due to outer chamber wall can be well explained by a simple optical approximation model at high frequencies. With an approximation of a wiggling chamber inside a wiggler, the coherent wiggler radiation (CWR) impedance has also been studied. Due to chamber shielding, the CWR impedance exhibits narrow peaks at frequencies satisfying the resonant conditions. (author)

  11. THE EVOLUTION OF CSR ACROSS LISTED BRAZILIAN FIRMS

    Directory of Open Access Journals (Sweden)

    Ana Gisbert

    2012-03-01

    Full Text Available This paper analyzes the improvements in corporate social responsibility (CSR among Brazilian companies listed on the Sao Paulo Stock Exchange – Bovespa, focusing on the type of social and environmental projects together with the amount of investments over the period 2003-2007. The empirical analysis is based on the content of the CSR reports of 48 companies, among them those making up the Bovespa’s Corporate Sustainability Index. All the identified social and environmental projects were classified into eleven categories and three investment categories: internal, external and environmental. The results show the need to standardize the CSR reports due to the absence of uniformity among the sample firms. The investment data reveal a significant increase in external investment projects, followed by the internal category. The results of the environmental category reveal only a moderate increase due to the reduction of the environmental investment in the petroleum industry. Overall, the results reveal that companies tend to invest in projects strongly linked to their main activities.

  12. Corporate Social Responsibility (CSR: A Scale Development Study in Iran

    Directory of Open Access Journals (Sweden)

    Kambiz Heidarzadeh Hanzaee

    2013-07-01

    Full Text Available The present research aims to explore a scale of Corporate Social Responsibility (CSR in Iran. In this way, it reviews the literature exist on corporate social responsibility, gathers data and analyzes the data to test the emerging trends. After confirmation of reliability, factor analysis and multi dimensional scaling are used to an established survey instrument. Finally CSR was achieved as a construct with five dimensions: obligation to employees, obligation to customers and markets, obligation to social programs and natural environment, obligation to laws and regulations and obligation to society. These five dimensions represent the corporate accountability to some different groups of its stakeholders. In this study the convenient samples of managers and employees used in collecting data and developing the scale, however in exploratory studies, this type of sampling can be acceptable. Nevertheless, some limitations should be taken into consideration, while interpreting the findings of the study and generalizing them to general business environment. Therefore enlarging the sample size and using a random sampling method of managers and employees in future studies has to make Corporate Social Responsibility (CSR scale more useful and enhance the generalization.

  13. Corporate Social Responsibility (CSR) and its relevance for the nuclear sector

    International Nuclear Information System (INIS)

    CSR has been gaining more and more importance in recent years, together with reporting initiatives and other attempts to create a more responsible business attitude. It often, however, remains mere window dressing, lacking a clear legal foundation. This paper will discuss some foundations of the CSR movement and position it into the context of governance of the nuclear sector. What can CSR contribute to the nuclear sector to increase the acceptability of nuclear and also enhance the regulatory framework for nuclear safety and environmental protection? It will be analysed how to strengthen CSR by giving it a more legal format. Can CSR become more enforceable and play a bigger role in steering businesses’ behaviour? This will also lead to questions concerning the internal structures of companies and how the right incentives within a corporation should be set, inspired by findings from CSR and Corporate Governance. (author)

  14. Introducing value-based framing as a strategy for communicating CSR

    DEFF Research Database (Denmark)

    Schmeltz, Line

    2014-01-01

    . Findings – Findings demonstrate that explicit communication of CSR framed as a corporate competence, and to some extent also as something personally relevant to the receivers, positively impacts evaluations of CSR messages and the companies behind them. Research limitations/implications – Findings indicate......Purpose – The purpose of this paper is to test how framing of CSR messages, based on a value-theoretical framework, impacts consumer perception of the CSR message. Design/methodology/approach – Quantitative study in the form of an online survey strongly inspired by classical experimental design...... that CSR messages could increasingly emphasize corporate competence with a lesser focus on moral ideas and commitments, and that framing strategies can be effective in creating CSR messages that will be positively evaluated by young consumers. Originality/value – This study contributes by providing new...

  15. Marknadsföring av Corporate Social Responsibility : En studie i Generation Y:s attityder till CSR samt attityder till marknadsföring av CSR inomsnabbmatsbranschen i Sverige

    OpenAIRE

    Pahkamaa, Tobias; Hamrin, Emil

    2012-01-01

    Denna uppsats undersöker konsumentgrupp Generation Y:s attityd till Corporate SocialResponsibility (CSR) samt marknadsföring av CSR. Vidare undersöks i uppsatsen Generation Y:sattityder till CSR samt marknadsföring av CSR gällande detaljister inom snabbmatsbranschen iSverige. Uppsatsens teoribildning baseras på teorier om attityder från framförallt Fishbein ochAjzen (1975), samt teorier om CSR och marknadsföring av CSR. Teorin knyts samman i enanalysmodell baserad på Wang och Andersons (2011)...

  16. CSR Policies: Effects on Labour Productivity in Spanish Micro and Small Manufacturing Companies

    OpenAIRE

    Pablo ESTEBAN SÁNCHEZ; Benito Hernandez, Sonia

    2013-01-01

    This paper analyses empirical evidence of efforts to enable Spanish micro and small manufacturing companies to boost their labour productivity rates through the development of the main pillars of their corporate social responsibility (CSR) policies. This study aims to develop new approaches and sensibilities towards work from an ethical, values (virtues) and CSR perspective, showing how internal dimensions of CSR, such those related to relationships with employees and responsibility in proces...

  17. CSR as Corporate Power. A Communication View Facebook Approach: An Exploratory Study

    OpenAIRE

    Anca Diana ȘERBAN

    2016-01-01

    This article aims to operationalize and measure the power of corporate communication and the main strategies that Romanian companies use to communicate their CSR campaigns on Facebook. The study conducts an extensive survey designed to emphasize the corporate communication indicators of power within CSR communication on Facebook and their correlation with the CSR communication strategy used by the first 100 biggest companies in Romania according to their turnover. The most important findings ...

  18. Private CSR Activities in Oligopolistic Markets: Is there any room for Regulation?

    OpenAIRE

    Evangelos Mitrokostas; Emmanuel Petrakis

    2008-01-01

    The present paper examines the conditions under which the regulator can complement the provision of Corporate Social Responsibility (CSR) activities by private firms in an oligopolistic market. Our main finding is that if there is no credible information disclosure about SR characteristics of the firms' products to consumers, no firm will have incentives to undertake CSR effort in equilibrium. However, if the necessary information about the CSR aspects of each firm's product, otherwise unobse...

  19. Importance of the Concept of Corporate Social Responsibility (CSR) in the Creation of Companies Value

    OpenAIRE

    Gołembski, Marcin; Wojtkowiak, Grzegorz

    2013-01-01

    In recent years, more and more interest (in view of building long-term value) of companies both large and those in the SME sector, has the concept of corporate social responsibility (CSR). The article attempts to identify the concept of CSR as a tool to build long-term value of the company. This text presents the results of empirical research on the level of business awareness of corporate social responsibility and performance and expected benefits of implementing CSR.

  20. The Role of Corporate Social Responsibility (CSR) in the Egyptian Banking Sector

    OpenAIRE

    Kamal, Mona

    2013-01-01

    Given the global recognition of Corporate Social Responsibility (CSR) of the financial institutions in developed countries and the lack of interest in the relevance of this concept in Egypt, it is essential to investigate the relation between Corporate Social Responsibility and Financial Performance (i.e. CSR-FP link) in the Egyptian banking sector. This paper explores, empirically, this association. The results imply a negative and statistically significant relationship between CSR-dimension...

  1. Corporate Sustainability/CSR Communications and Value Creation : A Marketing Approach

    OpenAIRE

    Mohamed, Bibri

    2008-01-01

    The purpose of this study is to explore the current practices in corporate sustainability/CSR communications and how this trend contributes to corporate value creation. More specifically, this study looks at this subject from the angle of how companies can use corporate sustainability/CSR communications in marketing activities to attain corporate marketing objectives. To achieve the aim of this study, an examination of the current practices in corporate sustainability /CSR communications was ...

  2. Decision support framework for resources allocation to corporate social responsibility (CSR) programmes

    OpenAIRE

    Poplawska, Jolanta

    2014-01-01

    Academia and business could benefit significantly from a framework allocating scarce resources to corporate social responsibility (CSR) programmes while considering the stakeholders’ importance. Methodologies that are capable of integrating CSR into business models in an operational way could be of great use. This thesis makes a contribution to knowledge by the development of a decision support methodology to allocate resources to CSR programmes. The research introduces the concepts of CS...

  3. Institutions and agency in CSR strategy: an empirical investigation of development and implementation

    OpenAIRE

    Bondy, Krista

    2008-01-01

    This PhD research started from an interest in how corporate social responsibility (CSR) works in practice and in identifying how to motivate companies to actively and meaningfully engage in CSR. It was further motivated by findings from previous research projects (Bondy et al 2004, Bondy 2006, Bondy 2007, Bondy et al 2008 forthcoming) which highlighted both the need for research in the area of CSR implementation, and the interesting issues around how corporations deal with the complexities of...

  4. Development of CSR Implementation Strategy Proposal. : Case: Kenkävero Association

    OpenAIRE

    Zhuvertseva, Valeriya

    2012-01-01

    The business world is awakening to an undeniable reality: our global economy, society and environment are inextricably aligned. The word of today is Corporate Social Responsibility. Up until recently, the CSR concept was generally considered by multinational enterprises exclusively, however, now small local firms see the benefits when applying CSR concept into their models. The aim of the study is the proposal of comprehensive and integrative framework for a CSR strategic implementation ...

  5. Company Stakeholder Responsibility : A Case Study of H&M and their CSR Strategy

    OpenAIRE

    Widmer, Matthias; Okara, Titus

    2012-01-01

    Problem: The scarcity of resources and increasing awareness of human rights issues in the media and the public are increasing the pressure on companies to introduce a Corporate Social Responsibility (CSR) strategy. Company Stakeholder Responsibility is a relatively new model in this field and is suggesting a wider approach to CSR. Purpose: The purpose of this thesis is to describe the topics of CSR, Stakeholder Theory and Company Stakeholder Responsibility and apply them in order to analyze t...

  6. Corporate social responsibility: How internal and external CSR perceptions influence employee outcomes

    OpenAIRE

    Kroh, Julia

    2014-01-01

    A Work Project, presented as part of the requirements for the Award of a Masters Degree in Management from the NOVA – School of Business and Economics Employees can be considered the inner workings of an organization. With CSR on the rise it is surprising to find comparatively little research exploring how CSR impacts such an existential stakeholder group. This study aims to theoretically explore and empirically test if internal and external CSR perceptions affect employees’ organizational...

  7. The Limits of Corporate Social Responsibility: Techniques of Neutralization, Stakeholder Management and Political CSR.

    Science.gov (United States)

    Fooks, Gary; Gilmore, Anna; Collin, Jeff; Holden, Chris; Lee, Kelley

    2013-01-01

    Since scholarly interest in corporate social responsibility (CSR) has primarily focused on the synergies between social and economic performance, our understanding of how (and the conditions under which) companies use CSR to produce policy outcomes that work against public welfare has remained comparatively under-developed. In particular, little is known about how corporate decision-makers privately reconcile the conflicts between public and private interests, even though this is likely to be relevant to understanding the limitations of CSR as a means of aligning business activity with the broader public interest. This study addresses this issue using internal tobacco industry documents to explore British-American Tobacco's (BAT) thinking on CSR and its effects on the company's CSR Programme. The article presents a three-stage model of CSR development, based on Sykes and Matza's theory of techniques of neutralization, which links together: how BAT managers made sense of the company's declining political authority in the mid-1990s; how they subsequently justified the use of CSR as a tool of stakeholder management aimed at diffusing the political impact of public health advocates by breaking up political constituencies working towards evidence-based tobacco regulation; and how CSR works ideologically to shape stakeholders' perceptions of the relative merits of competing approaches to tobacco control. Our analysis has three implications for research and practice. First, it underlines the importance of approaching corporate managers' public comments on CSR critically and situating them in their economic, political and historical contexts. Second, it illustrates the importance of focusing on the political aims and effects of CSR. Third, by showing how CSR practices are used to stymie evidence-based government regulation, the article underlines the importance of highlighting and developing matrices to assess the negative social impacts of CSR.

  8. How Spanish Multinationals implement CSR in Latin American countries: a focus on the energy sector

    OpenAIRE

    Llera Bagüés, Maria

    2009-01-01

    Spain is behind in the level of CSR implementation in comparison with other European countries, among other reasons due to low political commitment and support. In fact, private companies and in particular large corporations and multinationals are fostering the CSR arena in Spain, and despite the difficulties at home, the Spanish multinationals try to export their CSR initiatives abroad. Here, the energy sector is used as a guiding tool for the analysis due to the dominant position of the Spa...

  9. The Limits of Corporate Social Responsibility: Techniques of Neutralization, Stakeholder Management and Political CSR.

    Science.gov (United States)

    Fooks, Gary; Gilmore, Anna; Collin, Jeff; Holden, Chris; Lee, Kelley

    2013-01-01

    Since scholarly interest in corporate social responsibility (CSR) has primarily focused on the synergies between social and economic performance, our understanding of how (and the conditions under which) companies use CSR to produce policy outcomes that work against public welfare has remained comparatively under-developed. In particular, little is known about how corporate decision-makers privately reconcile the conflicts between public and private interests, even though this is likely to be relevant to understanding the limitations of CSR as a means of aligning business activity with the broader public interest. This study addresses this issue using internal tobacco industry documents to explore British-American Tobacco's (BAT) thinking on CSR and its effects on the company's CSR Programme. The article presents a three-stage model of CSR development, based on Sykes and Matza's theory of techniques of neutralization, which links together: how BAT managers made sense of the company's declining political authority in the mid-1990s; how they subsequently justified the use of CSR as a tool of stakeholder management aimed at diffusing the political impact of public health advocates by breaking up political constituencies working towards evidence-based tobacco regulation; and how CSR works ideologically to shape stakeholders' perceptions of the relative merits of competing approaches to tobacco control. Our analysis has three implications for research and practice. First, it underlines the importance of approaching corporate managers' public comments on CSR critically and situating them in their economic, political and historical contexts. Second, it illustrates the importance of focusing on the political aims and effects of CSR. Third, by showing how CSR practices are used to stymie evidence-based government regulation, the article underlines the importance of highlighting and developing matrices to assess the negative social impacts of CSR. PMID:23997379

  10. The Influence of Transverse CSR Structure on Headquarters/Subsidiary Integration

    OpenAIRE

    Luciano Barin Cruz; Eugênio Ávila Pedrozo; Vania de Fátima Barros Estivalete; Debora Nayar Hoff

    2010-01-01

    Some studies have already highlighted the effects of the introduction of Corporate Social Responsibility [CSR] projects into Multinational Corporations’ [MNC] strategies. However, little attention has been paid to the influence of transverse CSR structure on headquarters/subsidiary integration. In this article, we begin with the following question: What is the influence of the introduction of a centralized/decentralized structure on conducting a CSR strategy in a MNC? Our main objective is to...

  11. Determinants of Web-based CSR Disclosure in the Food Industry

    OpenAIRE

    Florian Sommer; Jeanette Klink; Daniela Senkl; Monika Hartmann

    2015-01-01

    Purpose –Web-based CSR disclosure provides a variety of advantages for firms. Determining factors for web-based CSR disclosure have been analyzed in several papers. However, only limited research has been conducted on both, the food industry and small and midsized enterprises. This paper is one contribution to fill this gap as we investigate web-based CSR communication of food processors including SME.Design/methodology/approach – We analyzed corporate communication on the website...

  12. Are firms with different CSR profiles equally innovative? Empirical analysis with survey data

    OpenAIRE

    Bocquet, Rachel; Christian LE BAS; Mothe, Caroline; Poussing, Nicolas

    2013-01-01

    This paper explores the relationship between corporate social responsibility (CSR) and innovation from a firm strategic perspective. Matching Community Innovation Survey data with specific data collected about the CSR behaviour of Luxembourg firms, the authors identify two types of firms (strategic versus responsive) that differ in the intensity of their CSR adoption. A bivariate probit model, estimated to explain the different types of technological innovations (product and/or process), show...

  13. Perception of CSR in Public & Private Companies : Case: Itella & Lidl Finland

    OpenAIRE

    Latif, Afaq

    2015-01-01

    Corporate social responsibility has become an improtant and key concept for today’s organizations. CSR refers to voluntarily behave in an ethical manner and contribute to economic development while, consecutively improving the society, workplace, and local community. The concept of CSR revolves around the notion of Triple Bottom Line, which is people, planet and profit. This study is specifically designed to study the concept of CSR and its perception in Public and Private companies in ...

  14. Should 'Responsibility' be written on the tin?: An exploration of CSR at XXXX

    OpenAIRE

    Gibson, Elizabeth Sarah

    2008-01-01

    The purpose of this report is to explore if and how a company known as XXXX could benefit from implementing a CSR policy into their business. Data was collected through a series of interviews and visits to XXXX and analysed in the light of the CSR literature. Strategic CSR can deliver business and societal benefits and the possibilities of this application to XXXX was explored. Through carefully examining the options available it is recommended that XXXX would benefit from exploring further t...

  15. Shareholder Influence on CSR: A Study of the Swedish Corporate Sector

    OpenAIRE

    Sjöström, Emma

    2009-01-01

    There is a growing expectation that shareholders can foster corporate social responsibility (CSR) through engagement activities. The aim of this study is therefore to explore the influence that shareholders have on corporations in terms of CSR. The study, which is set in Sweden, finds that corporations themselves do not perceive shareholders to have a significant direct influence on how they address CSR. At the same time, corporations find socially minded shareholders to be legitimate and imp...

  16. The Paradox of Power in CSR: A Case Study on Implementation

    OpenAIRE

    Bondy, Krista

    2008-01-01

    Purpose Although current literature assumes positive outcomes for stakeholders resulting from an increase in power associated with CSR, this research suggests that this increase can lead to conflict within organizations, resulting in almost complete inactivity on CSR. Methods A single in-depth case study, focusing on power as an embedded concept. Results Empirical evidence is used to demonstrate how some actors use CSR to improve their own positions within an organization. Resource ...

  17. What Drives Corporate Social Responsibility? Institutional Analysis of CSR in South Korean Context

    OpenAIRE

    Jung, Se Woo

    2013-01-01

    This dissertation seeks to explore the CSR drivers and to identify the social meaning of CSR in South Korea. To succeed in its aim, the dissertation will employ the institutional theory because it provides a framework of analysing various social aspects. Also, corporate citizenship theory is applied to discuss the role of government and an effect of globalisation as a key CSR driver. This paper defines globalisation in the South Korean context and how that benefits to the society. Further, to...

  18. Perceived corporate social responsibility (CSR) activities and the antecedents of customer loyalty in the airline industry

    OpenAIRE

    Asatryan, Roman; Asamoah, Emmanuel Selase

    2014-01-01

    In today’s world of business, consumers are increasingly expecting firms to engage in CSR and managers see it as marketing for competitive advantage. For the firms in the airline industry, their interest is how current and potential consumers would evaluate their CSR activities and more importantly whether it could lead to the creation of more loyal customers. The main objective of this study is to examine the impact of perceived corporate social responsibility (CSR) activities on the anteced...

  19. CORPORATE SOCIAL RESPONSIBILITY (CSR) SEBAGAI INSTRUMEN HUKUM EKONOMI DI ERA GLOBALISASI

    OpenAIRE

    Nur Sulistyo B. Ambarini

    2010-01-01

    Globalization of the world have substantial influence the development of the state and the country of Indonesia. One of the globalization trends that influence the development of economic law in Indonesia is the Corporate Social Responsibility (CSR). Corporate Social Responsibility (CSR) is a concept in economic activity associated with the embodiment of the concept of Sustainable Development . CSR arrangements in legislation, are a reflection of the principle of government intervention. In t...

  20. Dominance variation across six herbicides of the Arabidopsis thaliana csr1-1 and csr1-2 resistance alleles.

    Science.gov (United States)

    Roux, Fabrice; Matéjicek, Annick; Gasquez, Jacques; Reboud, Xavier

    2005-11-01

    Dominance of a resistance trait can be defined as a measure of the relative position of the phenotype of the heterozygote RS compared with the phenotype of the two corresponding homozygotes, SS and RR. This parameter has been shown to have primary importance in the dynamics of pesticide resistance evolution. Literature on insecticide resistance suggests that dominance levels in the presence of insecticide vary greatly from completely recessive to completely dominant. With insecticides, both the chemical applied and the dosages used have been demonstrated to affect the dominance. By contrast, almost all herbicide resistances have been found to be inherited as partially to totally dominant traits. This discrepancy between weeds and insects may partly result from the methodologies applied to measure the dominance, ie a single dose for herbicide versus several doses for insecticide. Using two well-known resistances (csr1-1 and csr1-2) to acetolactate synthase (ALS) inhibitors in Arabidopsis thaliana (L) Heynh (mouse-ear cress), we used several herbicide doses to determine the dominance level to six ALS-inhibiting herbicides. The dominance level in the presence of herbicide varied from completely dominant to completely recessive, depending on the resistance allele and the herbicide tested. The dominance of the csr1-1 and csr1-2 resistance alleles ranged from 0 (completely recessive) to 1.1 (dominant) and from 0 to 0.3 (partially dominant), respectively. The recessivity of some resistance alleles in the presence of herbicide could lead to the development of improved resistance management in order to delay or avoid herbicide resistance evolution, especially in the control of outcrossing weed species. PMID:16007690