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Sample records for cancer sites csr

  1. How Human Resource Professionals Use Electronic Channels to Communicate CSR : A case study focused on Solvay's French industrial sites

    OpenAIRE

    Fournet, Clara; Pauly, Marissa

    2015-01-01

    Corporate Social Responsibility (CSR) has become a large concern for many companies with the rise of globalization. Oftentimes, companies are encouraged to communicate CSR externally, but not internally. This research focuses upon the internal communication of CSR, specifically how Human Resource (HR) professionals use electronic channels to communicate to employees. The scope of this research is focused solely upon HR professionals within Solvay’s French industrial sites, which produce chemi...

  2. Political CSR

    DEFF Research Database (Denmark)

    Jeppesen, Søren; Morsing, Mette

    We engage a discussion of political CSR in SMEs in an African context. Based on critical observations on Western MNC CSR action in emerging economies that holds counterproductive implications for social development, political economists have argued that business profit far more than society...... in developing economies from CSR. In this paper we argue that local SMEs CSR work have strong influence in developing economies, that also includes counterproductive influence for social development. Based on empirical findings from African countries, we conceptualize how CSR in African SMEs differ from...... their European counterparts with their strong focus on retention of employees and support of extended households. We discuss how the African SME propensity to prioritize employees and extended households in CSR work in a paternalistic manner has productive as well as counterproductive implications for social...

  3. CSR communication

    DEFF Research Database (Denmark)

    Golob, Ursa; Podnar, Klement; Elving, Wim

    2013-01-01

    Purpose – This paper aims to introduce the special issue on CSR communication attached to the First International CSR Communication Conference held in Amsterdam in October 2011. The aim of the introduction is also to review CSR communication papers published in scholarly journals in order to make...... a summary of the state of CSR communication knowledge. Design/methodology/approach – The existing literature on CSR communication was approached via systematic review. with a combination of conventional and summative qualitative content analysis. The final dataset contained 90 papers from two main business...... and management databases, i.e. EBSCOhost and ProQuest. Findings – Papers were coded into three main categories. The results show that the majority of the papers are concerned with disclosure themes. Considerably less salient are papers that fall under process-oriented themes and the outcomes/consequences of CSR...

  4. Identification of a Csr system in Serratia marcescens 2170.

    Science.gov (United States)

    Ito, Manabu; Nomura, Kazuki; Sugimoto, Hayuki; Watanabe, Takeshi; Suzuki, Kazushi

    2014-01-01

    The carbon storage regulator (Csr) global regulatory system is conserved in many eubacteria and coordinates the expression of various genes that facilitate adaptation during the major physiological growth phase. The Csr system in Escherichia coli comprises an RNA-binding protein, CsrA; small non-coding RNAs, CsrB and CsrC; and a decay factor for small RNAs, CsrD. In this study, we identified the Csr system in Serratia marcescens 2170. S. marcescens CsrA was 97% identical to E. coli CsrA. CsrB and CsrC RNAs had typical stem-loop structures, including a GGA motif that is the CsrA binding site. CsrD was composed of N-terminal two times transmembrane region and HAMP-like, GGDEF, and EAL domains. Overexpression of S. marcescens csr genes complemented the phenotype of E. coli csr mutants. S. marcescens CsrD affected the decay of CsrB and CsrC RNAs in E. coli. These results suggest that the Csr system in S. marcescens is composed of an RNA-binding protein, two Csr small RNAs, and a decay factor for Csr small RNAs.

  5. CSR - Challenging Questions

    OpenAIRE

    Watson, Tom

    2014-01-01

    The presentation analyses current understandings of CSR and their visual representation; give examples of 'good' and 'bad' CSR/social marketing; considers the critical attack on CSR before presenting a checklist for communicators to use when developing CSR communication strategies.

  6. Empirical Analysis on CSR Communication in Romania: Transparency and Participation

    Directory of Open Access Journals (Sweden)

    Irina-Eugenia Iamandi

    2012-12-01

    Full Text Available In the specific field of corporate social responsibility (CSR, the participation of companies in supporting social and environmental issues is mainly analysed and/or measured based on their CSR communication policy; in this way, the transparency of the CSR reporting procedures is one of the most precise challenges for researchers and practitioners in the field. The main research objective of the present paper is to distinguish between different types of CSR participation by identifying the reasons behind CSR communication for a series of companies acting on the Romanian market. The descriptive analysis – conducted both at integrated and corporate level for the Romanian companies – took into account five main CSR communication related issues: CSR site, CSR report, CSR listing, CSR budget and CSR survey. The results highlight both the declarative/prescriptive and practical/descriptive perspectives of CSR communication in Romania, showing that the Romanian CSR market is reaching its full maturity. In more specific terms, the majority of the investigated companies are already using different types of CSR participation, marking the transition from CSR just for commercial purposes to CSR for long-term strategic use. The achieved results are broadly analysed in the paper and specific conclusions are emphasized.

  7. Progress of HIRFL-CSR Vacuum System

    Institute of Scientific and Technical Information of China (English)

    YangXiaotian; ZhangJunhui; MengJun; ZhangXijun; ZhangXiping; HouShengjun; HuZhenjun; NiuZhiwei; HaoBingan; WuHuimin

    2003-01-01

    The HIRFL-CSR vacuum system progressed steadily during the past year. The 2/3rd of CSR, injection beam line (SSC-CSR, m)'s vacuum chambers were installed in site in Jan. 2003 (Fig.l). The beam diagnostic devices were inserted in the chambers as well. The pressures in unbaked section were kept in 1~5×10-7 Pa range and in baked section were 2~5×10-9 Pa.

  8. State Cancer Profiles Web site

    Data.gov (United States)

    U.S. Department of Health & Human Services — The State Cancer Profiles (SCP) web site provides statistics to help guide and prioritize cancer control activities at the state and local levels. SCP is a...

  9. CSR as Aspirational Talk

    DEFF Research Database (Denmark)

    Christensen, Lars Thøger; Morsing, Mette; Thyssen, Ole

    2013-01-01

    Most writings on corporate social responsibility (CSR) treat lack of consistency between organizational CSR talk and action as a serious problem that needs to be eliminated. In this article, we argue that differences between words and action are not necessarily a bad thing and that such discrepan......Most writings on corporate social responsibility (CSR) treat lack of consistency between organizational CSR talk and action as a serious problem that needs to be eliminated. In this article, we argue that differences between words and action are not necessarily a bad thing...... and that such discrepancies have the potential to stimulate CSR improvements. We draw on a research tradition that regards communication as performative to challenge the conventional assumption that CSR communication is essentially superficial, as opposed to CSR action. In addition, we extend notions of organizational...... hypocrisy to argue that aspirational CSR talk may be an important resource for social change, even when organizations do not fully live up to their aspirations....

  10. Strategic CSR in Afghanistan

    DEFF Research Database (Denmark)

    Azizi, Sameer

    CSR is a rising phenomena in Afghanistan – but why are firms concerned about CSR in a least-developed context such as Afghanistan, and what are the strategic benefits? This paper is one of the first to explore these CSR issues in a least-developed country. It does so by focusing on CSR...... in the Afghan telecommunication sector and in particular on ‘Roshan’ as a case company. The findings of this paper are two-folded. First, it provides an overview of the CSR practices in the telecommunication sector in Afghanistan. Second, it focuses on one case and explains whether Roshan can gain strategic...... advantages through CSR in Afghanistan, and if so which and how these strategic benefits are gained. The paper shows that the developmental challenges of Afghanistan are the key explanations for why companies engage in CSR. Roshan has engaged in proactive CSR to overcome the contextual barriers for growth...

  11. CSR and Beyond

    DEFF Research Database (Denmark)

    Morsing, Mette; Strand, Robert

    2014-01-01

    Review of: CSR and Beyond. A Nordic Perspective Edited by Atle Midttun (Oslo: Cappelen Damm Akademisk, 2013)......Review of: CSR and Beyond. A Nordic Perspective Edited by Atle Midttun (Oslo: Cappelen Damm Akademisk, 2013)...

  12. CSR is dead. Long live CSR

    DEFF Research Database (Denmark)

    Rasche, Andreas; Morsing, Mette; Moon, Jeremy

    2017-01-01

    We should not focus too much on labels – labels come and labels go. CSR is a journey that has just begun and that continues to unfold on a daily basis.......We should not focus too much on labels – labels come and labels go. CSR is a journey that has just begun and that continues to unfold on a daily basis....

  13. CSR communication: quo vadis?

    NARCIS (Netherlands)

    Golob, U.; Podnar, K.; Elving, W.J.; Ellerup Nielsen, A.; Thomsen, C.; Schultz, F.

    2013-01-01

    Purpose - This paper aims to introduce the special issue on CSR communication attached to the First International CSR Communication Conference held in Amsterdam in October 2011. The aim of the introduction is also to review CSR communication papers published in scholarly journals in order to make a

  14. CSR in SMEs

    DEFF Research Database (Denmark)

    Lund-Thomsen, Peter; Jamali, Dima; Vives, Antonio

    (Fox, 2005). In fact, when it comes to their role in promoting corporate social responsibility (CSR) in developing countries, the verdict is still out there in terms of the extent to which SMEs engage in CSR, and whether their CSR involvement makes any difference to the profitability of firms, workers...

  15. CSR schemes in agribusiness

    DEFF Research Database (Denmark)

    Pötz, Katharina Anna; Haas, Rainer; Balzarova, Michaela

    2013-01-01

    Purpose – The rise of CSR followed a demand for CSR standards and guidelines. In a sector already characterized by a large number of standards, the authors seek to ask what CSR schemes apply to agribusiness, and how they can be systematically compared and analysed. Design....../methodology/approach – Following a deductive-inductive approach the authors develop a model to compare and analyse CSR schemes based on existing studies and on coding qualitative data on 216 CSR schemes. Findings – The authors confirm that CSR standards and guidelines have entered agribusiness and identify a complex landscape...... of schemes that can be categorized on focus areas, scales, mechanisms, origins, types and commitment levels. Research limitations/implications – The findings contribute to conceptual and empirical research on existing models to compare and analyse CSR standards. Sampling technique and depth of analysis limit...

  16. Three Tiers of CSR

    DEFF Research Database (Denmark)

    Aggerholm, Helle Kryger; Trapp, Leila

    2014-01-01

    Heightened concern with global issues has led to shifts in corporate social responsibility (CSR) programs. To capture the distinct nature of this global focus, researchers have developed a three-generation CSR typology. In this paper we first evaluate the usefulness of this typology...... for understanding corporate approaches to CSR by examining how several companies position themselves thematically in CEO introductions to sustainability reports. On the basis of this, we then evaluate the practical value of this typology for assisting those who work with CSR strategy. The analysis revealed...... expressions of all three CSR generations, with third generation thinking being apparent, but not dominant. It also verified that the three-generation CSR typology can be an instructive means of both evaluating as well as framing a company’s approach to sustainability, though with modifications. On the basis...

  17. Getting CSR communication fit

    DEFF Research Database (Denmark)

    Schmeltz, Line

    2017-01-01

    Companies experience increasing legal and societal pressure to communicate about their corporate social responsibility (CSR) engagements from a number of different publics. One very important group is that of young consumers who are predicted to be the most important and influential consumer group...... in the near future. From a value- theoretical base, this article empirically explores the role and applicability of ‘fit’ in strategic CSR communication targeted at young consumers. Point of departure is taken in the well-known strategic fit (a logical link between a company’s CSR commitment and its core...... values) and is further developed by introducing two additional fits, the CSR- Consumer fit and the CSR-Consumer-Company fit (Triple Fit). Through a sequential design, the three fits are empirically tested and their potential for meeting young consumers’ expectations for corporate CSR messaging...

  18. CSR in SMEs

    DEFF Research Database (Denmark)

    Lund-Thomsen, Peter; Jamali, Dima; Vives, Antonio

    2014-01-01

    Purpose -The aim of this article is to analyse the potential and limitations of donor-financed management tools that seek to promote CSR in small and medium-sized enterprises in developing countries. Drawing on key insights from three streams of literature relating to institutional theory, critical...... perspectives on CSR in developing countries, and the literature on CSR and SMEs in the developing world, we analyze the potential and limits of donor-financed management tools aimed at promoting CSR in developing country SMEs. Design/methodology/approach - Using official UN and OECD lists of all multilateral...... and bilateral donor agencies we identified 38 donors that might have produced such CSR tools. We contacted them via e-mail and/or telephone, and conductied an extensive internet search with the aim of identifying whether they had developed management tools aimed at promoting CSR in SMEs in developing countries...

  19. Communicating CSR is More Challenging than Paying CSR

    OpenAIRE

    Supriya Motwani

    2012-01-01

    In spite of the research on CSR being 50 years old, there is still no common definition of CSR. This field of study is not only theoretical & conceptually poor, but is also empirically unexplored. This is also true for CSR communication. CSR activities need to communicate because they may influence opinion leader’s behavior regarding a target organization. This potential for exploring CSR communication has lead us to develop a study that focuses on CSR communication practice & it’s challenges...

  20. Reporting consistently on CSR

    DEFF Research Database (Denmark)

    Thomsen, Christa; Nielsen, Anne Ellerup

    2006-01-01

    This chapter first outlines theory and literature on CSR and Stakeholder Relations focusing on the different perspectives and the contextual and dynamic character of the CSR concept. CSR reporting challenges are discussed and a model of analysis is proposed. Next, our paper presents the results...... of a case study showing that companies use different and not necessarily consistent strategies for reporting on CSR. Finally, the implications for managerial practice are discussed. The chapter concludes by highlighting the value and awareness of the discourse and the discourse types adopted...

  1. Can CSR be controlled?

    DEFF Research Database (Denmark)

    Kampf, Constance

    2009-01-01

    Associate Professor Constance Kampf talks about whether companies can control CSR or not, and she talks about the possible implications it can have if companies fail to live up their responsibilties. In that sense companies needs to consider the impact of the internet. She also gives advice on how...... to incorporate CSR in to the daily workflow....

  2. CSR in Afghanistan

    DEFF Research Database (Denmark)

    Azizi, Sameer; Jamali, Dima

    2016-01-01

    Purpose: – The purpose of this paper is to explain the emergence of CSR in Afghanistan as a novel context in the South-Asian CSR debate. Design/methodology/approach: – The findings of the paper are based on case studies of four corporations in the Afghan mobile telecommunications industry. Multiple...... space for manoeuvring for non-state actors to play a pivotal role in business-society relations. The paper highlights that the CSR practices are driven by the multi-level organisational field that through a unique blend of global coercive, mimetic and normative pressures lead to convergence around...... explicit CSR themes. Research limitations/implications: – The findings are based on CSR practices that are explicitly stated and do not include informal and/or implicit business-society practices in such contexts. Originality/value: – This paper combines the literature on areas of limited statehood...

  3. Conceptions of CSR in Japan

    DEFF Research Database (Denmark)

    Lystbæk, Christian Tang

    2014-01-01

    The objective of this paper is to advance an analysis of different conceptions of CSR in Japan after the Fukushima accident. The literature on CSR suggests that CSR is a complex term that has been open to a variety of interpretations. Until recently, CSR was mainly incorporated into Japanese...... concerns have raised crucial questions about environmental issues with regards to CSR. How do Japanese companies incorporate environmental issues into their CSR aims and achievements? What is the next strategic challenge for CSR in Japan? This paper will analyze the conceptualization of CSR in TEPCO...... used to understand CSR and the strategic challenges for CSR in Japan. Such a conceptual analysis provides important insight into how Japanese companies conceive of environmental issues and incorporate these into their CSR aims and achievements. As such, this paper will argue, part of the next strategic...

  4. The ribonucleoprotein Csr network.

    Science.gov (United States)

    Seyll, Ethel; Van Melderen, Laurence

    2013-11-08

    Ribonucleoprotein complexes are essential regulatory components in bacteria. In this review, we focus on the carbon storage regulator (Csr) network, which is well conserved in the bacterial world. This regulatory network is composed of the CsrA master regulator, its targets and regulators. CsrA binds to mRNA targets and regulates translation either negatively or positively. Binding to small non-coding RNAs controls activity of this protein. Expression of these regulators is tightly regulated at the level of transcription and stability by various global regulators (RNAses, two-component systems, alarmone). We discuss the implications of these complex regulations in bacterial adaptation.

  5. Strategisk CSR i store virksomheder

    OpenAIRE

    Færch, Maya Lauridsen

    2013-01-01

    This thesis examines the institutionalization of strategic CSR in large corporations in Denmark. The study focuses on how strategic CSR has become a part of the overall legitimizing paradigms in the Danish society, and whether the use of strategic CSR results in isomorphic tendencies among large corporations in Denmark. Furthermore, it examines how large corporations institutionalize strategic CSR in regards to the integration of strategic CSR in operational activities and the embedment of st...

  6. Religiosity, CSR attitudes, and CSR behavior : An empirical study of executives’ religiosity and CSR

    NARCIS (Netherlands)

    Mazereeuw, C.; Graafland, J.J.; Kaptein, M.

    2014-01-01

    In this paper, we examine the relationship between Christian religiosity, attitudes towards corporate social responsibility (CSR), and CSR behavior of executives. We distinguish four types of CSR attitudes and five types of CSR behavior. Based on empirical research conducted among 473 Dutch executiv

  7. CSR in Industrial Clusters

    DEFF Research Database (Denmark)

    Lund-Thomsen, Peter; Pillay, Renginee G.

    2012-01-01

    Purpose – The paper seeks to review the literature on CSR in industrial clusters in developing countries, identifying the main strengths, weaknesses, and gaps in this literature, pointing to future research directions and policy implications in the area of CSR and industrial cluster development...... in this field and their comments incorporated in the final version submitted to Corporate Governance. Findings – The article traces the origins of the debate on industrial clusters and CSR in developing countries back to the early 1990s when clusters began to be seen as an important vehicle for local economic...... development in the South. At the turn of the millennium the industrial cluster debate expanded as clusters were perceived as a potential source of poverty reduction, while their role in promoting CSR among small and medium-sized enterprises began to take shape from 2006 onwards. At present, there is still...

  8. Experiencing CSR in Asia

    DEFF Research Database (Denmark)

    Kampf, Constance Elizabeth

    2014-01-01

    This paper focuses on Corporate Social Responsibility (CSR) as strongly linked to expectations for corporations in the cultural con- texts in which they operate. Using an approach based in a macro-level for socio-technical design, it examines the interaction between digital activist efforts to (re......)define CSR and corporate responses to these ef- forts. Two cases of interaction between stakeholders and corporations with activist interventions are examined. Findings demonstrate that this interaction around CSR is often indirect, and misses a critical inter- action around contesting knowledge. This calls...... into question the via- bility of CSR practices mediated by policy and NGOs, because busi- nesses appear to be simply adopting mediators’ perspectives to avoid a crisis rather than a building a strategy based on critical engagement with the issues....

  9. CSR as Imperialism

    DEFF Research Database (Denmark)

    Lund-Thomsen, Peter; Khan, Farzad Rafi

    2011-01-01

    The voices of local manufacturers have largely been overlooked in academic and policy debates on corporate social responsibility (CSR) in the developing world. This article makes a contribution towards filling this gap in the literature by explicitly taking a phenomenological approach that maps...... the interpretations given to Western-based CSR initiatives by local manufacturers. Data from two qualitative research projects on CSR initiatives in the soccer ball industry of Sialkot, Pakistan, are utilized to explore this issue in an inductive and exploratory manner. The article suggests that many soccer ball...... manufacturers in Sialkot perceive CSR as part of the wider historic project of Western imperialism in the developing world through which economic resources are extracted from local manufacturers while their perceptions of what constitutes socially responsible behaviour are delegitimized. This counter...

  10. Governmentalities of CSR

    DEFF Research Database (Denmark)

    Vallentin, Steen

    2015-01-01

    This paper investigates the roles that Danish government has played in the development of corporate social responsibility (CSR). Denmark has emerged as a first mover among the Scandinavian countries when it comes to CSR. We argue that government has played a pivotal role in making this happen......, and that this reflects strong traditions of regulation, corporatism and active state involvement. However, there is no unitary “Danish model of CSR” being promoted by government. Although Danish society is often associated with a model of consensus, our claim is that Danish government policy on CSR is characterized...... of practice and show how they subject CSR to different modes of rationalization and action. We conclude that the problem with public policy being split into three is not different as such, but the failure of each regime to recognize the value of the others. As a result, government tends to add...

  11. CSR at Daimler

    OpenAIRE

    Geipel, Teresa

    2013-01-01

    Social responsibility of companies is a topic which has been more and more discussed during the last years. A lot of initiatives were started by the headline of Corporate Social Responsibility. But are these initiatives just window dressing or have employees really internalized the importance of Corporate Social Responsibility (CSR) and act according to the corporate principles? This project investigates on the CSR strategy and its implementation at the German multinational cooperation Daimle...

  12. Interaction of CSR1 with XIAP reverses inhibition of caspases and accelerates cell death.

    Science.gov (United States)

    Zheng, Zhong-Liang; Tan, Lang-Zhu; Yu, Yan P; Michalopoulos, George; Luo, Jian-Hua

    2012-08-01

    Cellular Stress Response 1 (CSR1) is a tumor suppressor gene that is located at 8p21, a region that is frequently deleted in prostate cancer as well as a variety of human malignancies. Previous studies have indicated that the expression of CSR1 induces cell death. In this study, we found that CSR1 interacts with X-linked Inhibitor of Apoptosis Protein (XIAP), using yeast two-hybrid screening analyses. XIAP overexpression has been found in many human cancers, and forced expression of XIAP blocks apoptosis. Both in vitro and in vivo analyses indicated that the C-terminus of CSR1 binds XIAP with high affinity. Through a series of in vitro recombinant protein-binding analyses, the XIAP-binding motif in CSR1 was determined to include amino acids 513 to 572. Targeted knock-down of XIAP enhanced CSR1-induced cell death, while overexpression of XIAP antagonized CSR1 activity. The binding of CSR1 with XIAP enhanced caspase-9 and caspase-3 protease activities, and CSR1-induced cell death was dramatically reduced on expression of a mutant CSR1 that does not bind XIAP. However, a XIAP mutant that does not interact with caspase-9 had no impact on CSR1-induced cell death. These results suggest that cell death is induced when CSR1 binds XIAP, preventing the interaction of XIAP with caspases. Thus, this study may have elucidated a novel mechanism by which tumor suppressors induce cell death.

  13. Public regulators and CSR

    DEFF Research Database (Denmark)

    Buhmann, Karin

    2016-01-01

    for responsible business conduct, connecting to social expectations and bridging to public regulation. This UN guidance has had a significant bearing on how public regulators seek to influence business conduct beyond Human Rights to broader Corporate Social Responsibility (CSR) concerns. Drawing on examples...... of such public regulatory governance, this article explores and explains developments towards a juridification of CSR entailing efforts by public regulators to reach beyond jurisdictional and territorial limitations of conventional public law to address adverse effects of transnational economic activity. Through...

  14. In silico identification and experimental characterization of regulatory elements controlling the expression of the Salmonella csrB and csrC genes.

    Science.gov (United States)

    Martínez, Luary C; Martínez-Flores, Irma; Salgado, Heladia; Fernández-Mora, Marcos; Medina-Rivera, Alejandra; Puente, José L; Collado-Vides, Julio; Bustamante, Víctor H

    2014-01-01

    The small RNAs CsrB and CsrC of Salmonella indirectly control the expression of numerous genes encoding widespread cellular functions, including virulence. The expression of csrB and csrC genes, which are located in different chromosomal regions, is coordinated by positive transcriptional control mediated by the two-component regulatory system BarA/SirA. Here, we identified by computational analysis an 18-bp inverted repeat (IR) sequence located far upstream from the promoter of Salmonella enterica serovar Typhimurium csrB and csrC genes. Deletion analysis and site-directed mutagenesis of the csrB and csrC regulatory regions revealed that this IR sequence is required for transcriptional activation of both genes. Protein-DNA and protein-protein interaction assays showed that the response regulator SirA specifically binds to the IR sequence and provide evidence that SirA acts as a dimer. Interestingly, whereas the IR sequence was essential for the SirA-mediated expression of csrB, our results revealed that SirA controls the expression of csrC not only by binding to the IR sequence but also by an indirect mode involving the Csr system. Additional computational, biochemical, and genetic analyses demonstrated that the integration host factor (IHF) global regulator positively controls the expression of csrB, but not of csrC, by interacting with a sequence located between the promoter and the SirA-binding site. These findings contribute to the better understanding of the regulatory mechanism controlling the expression of CsrB and CsrC.

  15. Campylobacter jejuni CsrA complements an Escherichia coli csrA mutation for the regulation of biofilm formation, motility and cellular morphology but not glycogen accumulation

    Directory of Open Access Journals (Sweden)

    Fields Joshua A

    2012-10-01

    Full Text Available Abstract Background Although Campylobacter jejuni is consistently ranked as one of the leading causes of bacterial diarrhea worldwide, the mechanisms by which C. jejuni causes disease and how they are regulated have yet to be clearly defined. The global regulator, CsrA, has been well characterized in several bacterial genera and is known to regulate a number of independent pathways via a post transcriptional mechanism, but remains relatively uncharacterized in the genus Campylobacter. Previously, we reported data illustrating the requirement for CsrA in several virulence related phenotypes of C. jejuni strain 81–176, indicating that the Csr pathway is important for Campylobacter pathogenesis. Results We compared the Escherichia coli and C. jejuni orthologs of CsrA and characterized the ability of the C. jejuni CsrA protein to functionally complement an E. coli csrA mutant. Phylogenetic comparison of E. coli CsrA to orthologs from several pathogenic bacteria demonstrated variability in C. jejuni CsrA relative to the known RNA binding domains of E. coli CsrA and in several amino acids reported to be involved in E. coli CsrA-mediated gene regulation. When expressed in an E. coli csrA mutant, C. jejuni CsrA succeeded in recovering defects in motility, biofilm formation, and cellular morphology; however, it failed to return excess glycogen accumulation to wild type levels. Conclusions These findings suggest that C. jejuni CsrA is capable of efficiently binding some E. coli CsrA binding sites, but not others, and provide insight into the biochemistry of C. jejuni CsrA.

  16. Regulation of bacterial virulence by Csr (Rsm) systems.

    Science.gov (United States)

    Vakulskas, Christopher A; Potts, Anastasia H; Babitzke, Paul; Ahmer, Brian M M; Romeo, Tony

    2015-06-01

    Most bacterial pathogens have the remarkable ability to flourish in the external environment and in specialized host niches. This ability requires their metabolism, physiology, and virulence factors to be responsive to changes in their surroundings. It is no surprise that the underlying genetic circuitry that supports this adaptability is multilayered and exceedingly complex. Studies over the past 2 decades have established that the CsrA/RsmA proteins, global regulators of posttranscriptional gene expression, play important roles in the expression of virulence factors of numerous proteobacterial pathogens. To accomplish these tasks, CsrA binds to the 5' untranslated and/or early coding regions of mRNAs and alters translation, mRNA turnover, and/or transcript elongation. CsrA activity is regulated by noncoding small RNAs (sRNAs) that contain multiple CsrA binding sites, which permit them to sequester multiple CsrA homodimers away from mRNA targets. Environmental cues sensed by two-component signal transduction systems and other regulatory factors govern the expression of the CsrA-binding sRNAs and, ultimately, the effects of CsrA on secretion systems, surface molecules and biofilm formation, quorum sensing, motility, pigmentation, siderophore production, and phagocytic avoidance. This review presents the workings of the Csr system, the paradigm shift that it generated for understanding posttranscriptional regulation, and its roles in virulence networks of animal and plant pathogens.

  17. Circuitry Linking the Catabolite Repression and Csr Global Regulatory Systems of Escherichia coli.

    Science.gov (United States)

    Pannuri, Archana; Vakulskas, Christopher A; Zere, Tesfalem; McGibbon, Louise C; Edwards, Adrianne N; Georgellis, Dimitris; Babitzke, Paul; Romeo, Tony

    2016-11-01

    Cyclic AMP (cAMP) and the cAMP receptor protein (cAMP-CRP) and CsrA are the principal regulators of the catabolite repression and carbon storage global regulatory systems, respectively. cAMP-CRP controls the transcription of genes for carbohydrate metabolism and other processes in response to carbon nutritional status, while CsrA binds to diverse mRNAs and regulates translation, RNA stability, and/or transcription elongation. CsrA also binds to the regulatory small RNAs (sRNAs) CsrB and CsrC, which antagonize its activity. The BarA-UvrY two-component signal transduction system (TCS) directly activates csrB and csrC (csrB/C) transcription, while CsrA does so indirectly. We show that cAMP-CRP inhibits csrB/C transcription without negatively regulating phosphorylated UvrY (P-UvrY) or CsrA levels. A crp deletion caused an elevation in CsrB/C levels in the stationary phase of growth and increased the expression of csrB-lacZ and csrC-lacZ transcriptional fusions, although modest stimulation of CsrB/C turnover by the crp deletion partially masked the former effects. DNase I footprinting and other studies demonstrated that cAMP-CRP bound specifically to three sites located upstream from the csrC promoter, two of which overlapped the P-UvrY binding site. These two proteins competed for binding at the overlapping sites. In vitro transcription-translation experiments confirmed direct repression of csrC-lacZ expression by cAMP-CRP. In contrast, cAMP-CRP effects on csrB transcription may be mediated indirectly, as it bound nonspecifically to csrB DNA. In the reciprocal direction, CsrA bound to crp mRNA with high affinity and specificity and yet exhibited only modest, conditional effects on expression. Our findings are incorporated into an emerging model for the response of Csr circuitry to carbon nutritional status.

  18. HIRFL-CSR complex

    Institute of Scientific and Technical Information of China (English)

    XIA Jia-Wen; ZHAN Wen-Long; WEI Bao-Wen; YUAN You-Jin; YUAN Ping; QIAO Wei-Min; GAO Da-Qing; YANG Xiao-Tian; MAN Kai-Di; XIAO Guo-Qing; ZHAO Hong-Wei; YANG Xiao-Dong; CAI Xiao-Hong; SONG Ming-Tao; XU Hu-Shan; MA Li-Zhen; LIU Yong; HE Yuan; ZHOU Zhong-Zu; ZHANG Wei; XU Zhe; MAO Rui-Shi; ZHANG Jun-Hui; JING Lan; YANG Ya-Qing; YANG Jian-Cheng; MAO Li-Jun; CHEN You-Xin

    2009-01-01

    The construction and commissioning of HIRFL-CSR were finished in 2007. From 2000 to 2005 the subsystem and key devices of CSR were successfully fabricated, such as magnet, power supply, UHV system, e-cooler, electric-static deflector with the septum of 0.1 mm, and the fast-pulse kicker with the rise time of 150 ns. After that the CSR commissioning activities were performed in 2006 and 2007, including the accumulation of those heavy ions of C, At, Kr and Xe by the combination of stripping injection (STI) or multiple multi-turn injection (MMI) and e-cooling with a hollow e-beam, wide energy-range synchrotron ramping by changing the RF harmonic-number at mid-energy, the beam stacking in the experimental ring CSRe, the RIBs mass-measurement with the isochronous-mode in CSRe by using the time-of-flight method, and the ion beam slow-extraction from CSRm.

  19. CSR Model Implementation from School Stakeholder Perspectives

    Science.gov (United States)

    Herrmann, Suzannah

    2006-01-01

    Despite comprehensive school reform (CSR) model developers' best intentions to make school stakeholders adhere strictly to the implementation of model components, school stakeholders implementing CSR models inevitably make adaptations to the CSR model. Adaptations are made to CSR models because school stakeholders internalize CSR model practices…

  20. Cancer incidence in Italian contaminated sites

    Directory of Open Access Journals (Sweden)

    Pietro Comba

    2014-06-01

    Full Text Available INTRODUCTION. The incidence of cancer among residents in sites contaminated by pollutants with a possible health impact is not adequately studied. In Italy, SENTIERI Project (Epidemiological study of residents in National Priority Contaminated Sites, NPCSs was implemented to study major health outcomes for residents in 44 NPCSs. METHODS. The Italian Association of Cancer Registries (AIRTUM records cancer incidence in 23 NPCSs. For each NPCSs, the incidence of all malignant cancers combined and 35 cancer sites (coded according to ICD-10, was analysed (1996-2005. The observed cases were compared to the expected based on age (5-year period,18 classes, gender, calendar period (1996-2000; 2001-2005, geographical area (North-Centre and Centre-South and cancer sites specific rates. Standardized Incidence Ratios (SIR with 90% Confidence Intervals were computed. RESULTS. In both genders an excess was observed for overall cancer incidence (9% in men and 7% in women as well as for specific cancer sites (colon and rectum, liver, gallbladder, pancreas, lung, skin melanoma, bladder and Non Hodgkin lymphoma. Deficits were observed for gastric cancer in both genders, chronic lymphoid leukemia (men, malignant thyroid neoplasms, corpus uteri and connective and soft-tissue tumours and sarcomas (women. DISCUSSION. This report is, to our knowledge, the first one on cancer risk of residents in NPCSs. The study, although not aiming to estimate the cancer burden attributable to the environment as compared to occupation or life-style, supports the credibility of an etiologic role of environmental exposures in contaminated sites. Ongoing analyses focus on the interpretation of risk factors for excesses of specific cancer types overall and in specific NPCSs in relation to the presence of carcinogenic pollutants.

  1. Status of the HIRFL–CSR complex

    Energy Technology Data Exchange (ETDEWEB)

    Yuan, Y.J. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Yang, J.C., E-mail: yangjch@impcas.ac.cn [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Xia, J.W.; Yuan, P.; Qiao, W.M.; Gao, D.Q.; Xiao, G.Q.; Zhao, H.W.; Xu, H.S.; Song, M.T.; Yang, X.D.; Cai, X.H.; Ma, L.Z.; Yang, X.T.; Man, K.T.; He, Y.; Zhou, Z.Z.; Zhang, J.H.; Xu, Z.; Liu, Y. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); and others

    2013-12-15

    Highlights: • HIRFL is in a very positive state and can provide all ion species with maximum energy to 1 GeV/u (A/q = 2). • Present status of HIRFL complex is given as well as the new progress on operation and improvement. • With emphasize on HIRFL–CSR project, main features realized during the commissioning and operation are described in detail. • The progress on physics experiments and hadron cancer therapy are also presented. -- Abstract: The HIRFL–CSR, as an upgrade of the HIRFL, has been put into operation since 2008. Together with a series of improvements of injector cyclotrons, the HIRFL is in a very good state and can provide all ion species from proton to uranium with energy variable from ion source energy to 1 GeV/u (A/q = 2). Present status of the HIRFL–CSR complex is given. Main features realized during the commissioning and operation are described in detail. The progress on physics experiments and cancer therapy are also presented.

  2. CSR Pulsed Switching Power Supplies

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    In 2001, CSR power supply system made a great progress. Three prototypes were designed for CSR quadruple and correct magnet. Three different companies provided the three prototypes, but the same circuit-chopper were employed. The simplified diagram is showed in Fig.1. All pulsed switching power supply prototypes were tested successfully before the end of 2001.

  3. CSR-1 Slices a Balance.

    Science.gov (United States)

    Yu, Ruby; Moazed, Danesh

    2016-04-07

    CSR-1 is a germline-expressed C. elegans Argonaute protein essential for viability. In this issue of Cell, Gerson-Gurwitz et al. now demonstrate a role for CSR-1 and its slicer activity in downregulating the levels of maternally deposited mRNAs to fine-tune the expression of proteins with critical roles in embryonic cell divisions.

  4. Integrated reporting with CSR practices

    DEFF Research Database (Denmark)

    Lueg, Klarissa; Lueg, Rainer; Andersen, Karina;

    2016-01-01

    Purpose: This study aims to illustrate how standards and guidelines for corporate social responsibility (CSR) can help a company in its integrated reporting (IR). We investigate the motivations of diverse stakeholders (including shareholders) in fostering the adoption of standards and guidelines...... for CSR after IR became mandatory in Denmark. Methodology: We conduct a case study at the Danish carpet manufacturer EGE. We interpret the case from the perspective of pragmatic constructivism, which focuses on the integration of four dimensions: facts, possibilities, values, and communication. Findings......: We find that the family-owned EGE follows a strategy of “enlightened shareholder value”, in which CSR is an essential value driver. This strategy fostered IR with guidelines and standards for CSR. The CSR practices appeared to be helpful for integrating measureable plans to the strategy...

  5. Providing Southern Perspectives on CSR

    DEFF Research Database (Denmark)

    Jeppesen, Søren; Kothuis, Bas

    The article seeks to contribute to the SMEs and CSR literature in developing countries by providing; a) a ‘Southern’ SME perspective, which includes the voices of managers and workers, b) a perspective of CSR, which opens up to informal CSR practices that SMEs undertake, and c) an analysis...... of the key institutional issues affecting the CSR practices of SMEs. It presents perceptions of CSR practices among 21 SMEs in the garment industry in South Africa, based on 40 interviews with managers and 19 interviews with workers through the use of qualitative and quantitative interview frameworks....... It highlights a high degree of similarities between managers and workers, though knowledge of (cognitive level) the concept ‘CSR’ differ considerably. Informal practices are widespread and of key importance to the SMEs, expressed by managers and workers alike. History, industry and manager-workers relations...

  6. CSR as Corporate Political Activity

    DEFF Research Database (Denmark)

    Morsing, Mette; Roepstorff, Anne

    2015-01-01

    In this article, we develop a conceptual framework to understand how a company’s CSR identity becomes defined as a political activity destabilizing the strong identity–image relations. We draw on theories of political CSR and organizational identity–image relations to study how CSR emerges...... as a corporate political activity in a context where the corporate CSR work is first appreciated and later critiqued by the public in the wake of socio-political events. We analyse the micro-organizational processes in the context of macro-political level changes, and we refer to this as the ‘identity......–image dynamics of political CSR’. Concretely, we describe in two vignettes how IKEA’s declared ‘apolitical and neutral’ CSR identity becomes entangled with national and international socio-political events that critically challenge the corporate engagement prior national understandings of citizenship rights...

  7. Turning CSR on it's head

    DEFF Research Database (Denmark)

    Kampf, Constance Elizabeth

    CSR takes a stakeholder approach that considers a broader definition of people who can affect and are affected by firms (Freeman 1984, Donaldson & Preston 1995). Currently, CSR is conceptualized from the perspective of firms choosing their practices based on communication with these stakeholders...... on its head, Carrotmob.org turns a firm-focused understanding of the CSR conversation upside down by providing a platform for consumers to bring their ideas about CSR to local firms, engaging the firms in a competition to pledge a percentage of their profits during an afternoon towards reducing...... their ecological footprint. Then CarrotMob members use social media to recruit as many customers as possible to shop at that time, thus increasing both profits and available resources for the business to engage in sustainability. As sustainability and CSR are enacted differently in the US and EU (Matten and Moon...

  8. The Cultural and Rhetorical Parameters of CSR

    DEFF Research Database (Denmark)

    Kampf, Constance

    Ethics. 62: 355-366.   Donaldson, T. & Preston, L. E. (1995). Stakeholder Theory of the Corporation: Concepts, Evidence, and Implications. The Academy of Management Review. 20(1): 65-91.   Kampf, C. (2007). Corporate Social Responsibility: WalMart, Maersk and the Cultural Bounds of Representation......How are the parameters of CSR constructed?-corporate communication policy or the interaction between civil society, governments, and corporations? Recognition of the presentation of CSR on the Web as socially constructed argumentation (Coupland 2005) opens the door for a rhetorical approach to both...... at how these sites are perceived by intended audiences. This business-centered approach to understanding corporate web presences parallels current stakeholder models such as Donaldson and Preston (1995), which also focus on the corporation as the central focus for stakeholder interactions.   However...

  9. CSR in TSL companies

    Directory of Open Access Journals (Sweden)

    Joanna DYCZKOWSKA

    2015-03-01

    Full Text Available TSL companies are characterized by high dynamics of an increase of incomes, and hence increased shipping. Owing to a rational policy in the area of the consolidation of production and distribution, they may boast of a better use of the means of transport. The purpose of this article is to present the activities in the area of the eco-friendly CSR aspect in the activities of TSL companies taking into consideration particularly logistic operators. The research methods used in the study include an analysis of secondary data, observations and comparative analyses. Road transport in the shipping structure comes first and it constitutes 84% of freights. In the year 2009, in Poland greenhouse gas emissions from road transport amounted to 42.5 million tons (4.84% of the EU member states and CO emissions were 41.9 million tons (analogically, 4.83% of environment pollutions in the European Union. This causes an emission of fumes into the atmosphere. The policy of sustainable development pursued by logistic operators under corporate social responsibility is a response to the abovementioned data. They take decisions concerning social and environmental aspects. The activities of TSL companies under CSR need to provide an answer to customer expectations and needs, and they have to cause an increase of competitiveness on the market. The selected four largest logistic operators conduct the following eco-friendly activities on the highest level: fume emission reports and the control of these emissions, transport of hazardous goods (ADR, voluntary services in the scope of environmental protection and cooperation with eco-friendly organizations. There are those activities which call for improvement: a limitation of the emission of fumes, waste management and sewage treatment policy.

  10. [Risk factors of main cancer sites].

    Science.gov (United States)

    Uleckiene, Saule; Didziapetriene, Janina; Griciūte, Liudvika Laima; Urbeliene, Janina; Kasiulevicius, Vytautas; Sapoka, Virginijus

    2008-01-01

    Cancer prevention is a system of various measures devoted to avoid this disease. Primary cancer prevention means the identification, avoidance, or destruction of known risk factors. The main risk factors are smoking, diet, alcohol consumption, occupational factors, environmental pollution, electromagnetic radiation, infection, medicines, reproductive hormones, and lack of physical activity. Approximately one-third of cancers can be avoided by implementing various preventive measures. The aim of this article was to acquaint medical students, family doctors with risk factors of main cancer sites (lung, breast, colorectal, and prostate).

  11. CSR's effect on brand image

    OpenAIRE

    Gudjonsdottir, Elly; Jusubova, Albina

    2015-01-01

    The purpose of this study is to investigate CSR’s effect on brand image in order to increase the understanding of CSR as a marketing tool, within the service industry. The research questions of the study are “How does a service-based company’s involvement in CSR as a marketing strategy affect the brand image? And how do the different CSR dimensions affect the brand image?” This study has a positive and deductive approach with a cross sectional design. The quantitative method chosen was a ques...

  12. CSR, SMEs and Social Capital

    DEFF Research Database (Denmark)

    Murillo, David; Vallentin, Steen

    2012-01-01

    capital are interrelated, turning social capital into a powerful instrument to better explain what academic literature has called silent CSR practices. The analysis that follows questions some of the basic tenets that underpin the branch of business ethics that deals with the nature of SMEs' approach...... this type of action d) Any study of this kind of practice requires a dual approach: a) normative when using tools developed by CSR; and b) descriptive and instrumental using the notion of social capital....

  13. A direct link between the global regulator PhoP and the Csr regulon in Y. pseudotuberculosis through the small regulatory RNA CsrC.

    Science.gov (United States)

    Nuss, Aaron M; Schuster, Franziska; Kathrin Heroven, Ann; Heine, Wiebke; Pisano, Fabio; Dersch, Petra

    2014-01-01

    In this study we investigated the influence of the global response regulator PhoP on the complex regulatory cascade controlling expression of early stage virulence genes of Yersinia pseudotuberculosis via the virulence regulator RovA. Our analysis revealed the following novel features: (1) PhoP activates expression of the CsrC RNA in Y. pseudotuberculosis, leading to activation of RovA synthesis through the CsrABC-RovM cascade, (2) activation of csrC transcription is direct and PhoP is shown to bind to two separate PhoP box-like sites, (3) PhoP-mediated activation results in transcription from two different promoters closely downstream of the PhoP binding sites, leading to two distinct CsrC RNAs, and (4) the stability of the CsrC RNAs differs significantly between the Y. pseudotuberculosis strains YPIII and IP32953 due to a 20 nucleotides insertion in CsrC(IP32953), which renders the transcript more susceptible to degradation. In summary, our study showed that PhoP-mediated influence on the regulatory cascade controlling the Csr system and RovA in Y. pseudotuberculosis varies within the species, suggesting that the Csr system is a focal point to readjust and adapt the genus to different hosts and reservoirs.

  14. CSR in Publicly Owned Enterprises

    DEFF Research Database (Denmark)

    Lauesen, Linne Marie

    2011-01-01

    Purpose – CSR in water utilities in Denmark faces various challenges in getting to the same level as in private organisations. The water utilities are newly privatised, hybrid organisations that are both professionally and politically driven. The purpose of this paper is an examination of the opp......Purpose – CSR in water utilities in Denmark faces various challenges in getting to the same level as in private organisations. The water utilities are newly privatised, hybrid organisations that are both professionally and politically driven. The purpose of this paper is an examination...... of the opportunities and barriers in CSR in these publicly owned enterprises (POEs). The research question is: why do the opportunities of CSR in POEs seem more beneficial than for normal private businesses, while the barriers seem to slow the progression? The opportunities lie in the closeness to and willingness...... of the political decision-makers of the city. The barriers to CSR in POEs stem from the legal regulatory framework, which dictates efficiencies, price and cost reductions and limits the ethical investments of the POEs. Design/methodology/approach – The methodology of the paper is a comparative study and analysis...

  15. Governmentality and the Politics of CSR

    DEFF Research Database (Denmark)

    Vallentin, Steen; Murillo, David

    2012-01-01

    of power and governing that are prevalent in governmental approaches to CSR in general and in neoliberal modes of CSR governance in particular. Using EU and member states policy developments as an empirical backdrop, we provide a conceptual exploration of the prospects of applying governmentality...... to the study of the changing roles of government in CSR. We position our contribution within the critical literature on CSR as a political phenomenon....

  16. Meaningful CSR Communication via Digital Media

    OpenAIRE

    Osborne, N.; Bolat, Elvira; Memery, Juliet

    2016-01-01

    It has regularly been stated that consumer demand for CSR is larger than ever, but do consumers really want to be informed about the ethical behaviour of brands? Does digital media have an impact on meaningful CSR communication? A research analysing consumer reaction to social media posts about CSR is limited. Using mixed method, this study examined the UK consumer attitudes towards CSR and its communication in digital media plus its consequent effect on purchasing intentions. Results indicat...

  17. Harmonization in CSR reporting: MNEs and global CSR standards

    NARCIS (Netherlands)

    F. Fortanier; A. Kolk; J. Pinkse

    2011-01-01

    This paper focuses on MNEs’ corporate social responsibility (CSR) reporting, which previous studies have found to exhibit strong country-of-origin effects. It examines whether MNEs’ adherence to global standards (as adopted by e.g. ILO, OECD, UN, ISO) is associated with smaller cross-country differe

  18. CSR:New Engine of Economic Recovery

    Institute of Scientific and Technical Information of China (English)

    Guo Yan

    2010-01-01

    @@ Nowadays, China has more and more focused Corporate Social Responsibility (CSR). From October 2009, more than 600 Chinese companies have released CSR reports. According to statistics from China WTO Tribune, in 2009 China issued a total of 631 CSR reports, 3.73 times more than that released in 2008.

  19. Regulatory Interactions of Csr Components: the RNA Binding Protein CsrA Activates csrB Transcription in Escherichia coli

    OpenAIRE

    Gudapaty, Seshagirirao; Suzuki, Kazushi; Wang, Xin; Babitzke, Paul; Romeo, Tony

    2002-01-01

    The global regulator CsrA (carbon storage regulator) of Escherichia coli is a small RNA binding protein that represses various metabolic pathways and processes that are induced in the stationary phase of growth, while it activates certain exponential phase functions. Both repression and activation by CsrA involve posttranscriptional mechanisms, in which CsrA binding to mRNA leads to decreased or increased transcript stability, respectively. CsrA also binds to a small untranslated RNA, CsrB, f...

  20. Analysis of Cheminova CSR practice

    DEFF Research Database (Denmark)

    Jørgensen, Michael Søgaard; Milanez, Bruno; Porto, Marcelo Firpo

    This working paper is part of a case study about the international environmental and social performance of the multinational Danish pesticide manufacturing and marketing company Cheminova. In the paper the practice of Cheminova is described and characterised based on its CSR reports from 2007...

  1. Requirements management: A CSR's perspective

    Science.gov (United States)

    Thompson, Joanie

    1991-01-01

    The following subject areas are covered: customer service overview of network service request processing; Customer Service Representative (CSR) responsibility matrix; extract from a sample Memorandum of Understanding; Network Service Request Form and its instructions sample notification of receipt; and requirements management in the NASA Science Internet.

  2. Gender, CSR and Feminist Organization Studies

    DEFF Research Database (Denmark)

    Grosser, Kate; Moon, Jeremy

    2016-01-01

    this scholarship often fails to explicitly reference feminist theory, and particularly that deriving from feminist organization studies (FOS). The first contribution of our paper is to address this gap by reviewing developments in feminist organization theory, and mapping their relevance to CSR. Our second...... contributions to gender and CSR scholarship will come from research that is well grounded in both feminist and CSR theory.......Corporate Social Responsibility (CSR) practice increasingly addresses gender issues (e.g. Women’s Empowerment Principles Global Reporting Initiative, United Nations Global Compact, Ethical Trading Initiative), and research on gender and CSR is rapidly expanding. Yet beyond feminist ethics...

  3. External CSR Communication in a Strategic Approach

    Directory of Open Access Journals (Sweden)

    Diana Corina GLIGOR-CIMPOIERU

    2014-12-01

    Full Text Available As part of a strategic approach, aimed at assuring mutual benefits for the social cause and the business organization, a good CSR - Corporate Social Responsibility communication is vital for the success of a CSR program. We argue that there is not a problem with the legitimacy of the CSR concept, but rather to its implementation. If a business organization implementing socially responsible initiatives is focusing only on reaping the image benefits from a simple public relations perspective, then it loses all the potential business benefits it could gain from a strategic approach focused on long term real results in a win-win perspective. The fact that the image benefit is one of the most important incentives that a business organization could obtain for engaging in CSR activities cannot be ignored, and that is the reason why we have chosen to analyse the topic of CSR communication, mainly external communication, as an important link in the process of implementing a CSR program, that plays an important part for the success of a CSR program. The approach on CSR communication should definitely be a strategic one, and long already common forms of external CSR communication like web pages or CSR annual reports new means of social media networks have an increasing importance. For the practical part of the paper, we were interested in analyzing how much of the external CSR communication in the Romanian business environment is oriented toward a traditional or a strategic approach.

  4. Reflexive regulation of CSR to promote sustainability

    DEFF Research Database (Denmark)

    Buhmann, Karin

    2011-01-01

    This article discusses Corporate Social Responsibility (CSR) from the perspective of governmental regulation as a measure to promote public policy interests through public-private regulation intended to influence firms’ self-regulation. Presenting a ‘government case’ for CSR, the connection between...... climate change and environmental sustainability, and social, economic and other human rights lend human rights as part of CSR a potential for meeting some environmental and climate concerns and handling adverse side-effects. The article analyses two EU initiatives: The EU Multi-Stakeholder (MSF) on CSR...... and the EU CSR Alliance. Focusing on human rights based in international law, it analyses the patterns of negotiation in the MSF and the background for the launch of the CSR Alliance. It shows that analysing public-private regulation of CSR from the perspective of reflexive law theory assists us...

  5. CSR Gravity Field Data Products

    Science.gov (United States)

    Bettadpur, Srinivas

    2014-05-01

    The joint NASA/DLR GRACE mission has successfully operated for nearly 12 years, and has provided a remarkable record of global mass flux due to a large variety of geophysical and climate processes at various spatio-temporal scales. The University of Texas Center for Space Research (CSR) hosts the mission PI, and is responsible for delivery of operational (presently denoted as Release-05 or RL05) gravity field data products. In addition, CSR generates and distributes a variety of other gravity field data products, including products generated from the use of satellite laser ranging data. This poster will provide an overview of all these data products, their relative quality, potential applications, and future plans for their development and delivery.

  6. CSR Practices at Bank Islam Malaysia Berhad (BIMB: Managing CSR Fund

    Directory of Open Access Journals (Sweden)

    Fathiyyah Abu Bakar

    2014-03-01

    Full Text Available The notion of CSR from Islamic perspective has been viewed as a comprehensive discourse when it is already embedded the element of spiritual (Tawhid and Taqwa, economics, ethics and legality. However, there is a black box in the process of managing CSR fund which is used to conduct the CSR initiatives. Thus, this study attempts to revisit the issues by discussing Islamic concept of CSR practices and to gain insights the process of managing various sources of CSR fund. By using case study approach, a group of key CSR players at Bank Islam Malaysia Berhad as well as the recipients of the initiatives have been interviewed. Moreover, an in-field observation and CSR documentations analysis have been employed to get the whole picture of managing the CSR activities and also the fund. The results show that he CSR initiatives at the bank are highly associated with religious obligations and the main source of CSR fund is derived from the zakat fund. In addition, donation, non-compliance Shariah income and purification fund have been used to fulfill various stakeholders' demands. Thus, these findings provide an avenue to conceptualize the concept and practices of CSR in Islamic view and encourage other business entities to manage their financial resources (CSR fund systematically to support the CSR activities.

  7. Electron cooling experiments in CSR

    Institute of Scientific and Technical Information of China (English)

    PARKHOMCHUK; Vasily; REVA; Vladimir

    2011-01-01

    The six species heavy ion beam was accumulated with the help of electron cooling in the main ring of Cooler Storage Ring of Heavy Ion Research Facility in Lanzhou (HIRFL-CSR). The ion beam accumulation dependence on the parameters of cooler was investigated experimentally. The 400 MeV/u 12C6+ and 200 MeV/u 129Xe54+ were stored and cooled in the experimental ring CSRe, and the cooling force was measured in different conditions.

  8. Electron Cooling Experiments in CSR

    CERN Document Server

    Xiaodong, Yang

    2011-01-01

    The six species heavy ion beam was accumulated with the help of electron cooling in the main ring of Cooler Storage Ring of Heavy Ion Research Facility in Lanzhou(HIRFL-CSR), the ion beam accumulation dependence on the parameters of cooler was investigated experimentally. The 400MeV/u 12C6+ and 200MeV/u 129Xe54+ was stored and cooled in the experimental ring CSRe, the cooling force was measured in different condition.

  9. Operationalizing CSR through Project Conception

    DEFF Research Database (Denmark)

    Kampf, Constance Elizabeth

    2013-01-01

    The purpose of this paper is to address issues raised about the content of business education—moving away from a business-centered approach to understanding management, opening up a space for reflection, and offering tools to support this change in paradigm. Strand points out these issues as “rel...... of project conception by management can be understood as the place where CSR and sustainability practices can be operationalized in the base unit of work for many corporations—the project....

  10. CSR Important to Oil Companies

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ Corporations are human endeavors, and all human endeavors should benefit our society and reflect our morals. They should provide more than just investor return. The nature of oil industry demands that oil companies be socially responsible in addition to operating in an ethical and environmentally friendly manner. At a time of rising energy prices and global concern over our energy future, however, oil companies should give even greater emphasis to this part of their approach to corporate social responsibility(CSR).

  11. Embodying CSR through Aligned Communication

    DEFF Research Database (Denmark)

    Thomsen, Elisabeth Houe

    2017-01-01

    Efter den finansielle krises start i 2008, som angiveligt blev udløst af misbrug af realkreditlån i den finansielle sektor, syntes det ret fristende for en række virksomheder i den finansielle sektor - såvel som andre sektorer - at ty til at bruge CSR-kommunikation som løftestang til at forbedre et...... noget plettet image og omdømme, der efterfølgende hang ved hele sektoren - uanset om den pågældende virksomhed faktisk var skyldig i at bidrage til krisen. Midt i denne tendens til at bruge og nogle gange misbruge CSR-kommunikation valgte enkelte virksomheder ikke at bruge denne løftestang - en af ​​dem...... er den lille danske bank Merkur, som dette casestudie omhandler. Som en bæredygtig bank, der primært lever af at låne penge til erhvervskunder, der har engageret sig i at fokusere på bæredygtighed, vælger Merkur aktivt og bevidst ikke at kommunikere CSR i den mere konventionelle forstand gennem tekst...

  12. The Indonesian Executives Perspective of CSR Practices

    Directory of Open Access Journals (Sweden)

    Hasan Fauzi

    2014-09-01

    Full Text Available The objective of this study is to investigate the CSR (Corporate Social Responsibility practices after the issuance of the government regulation as the implementation guideline of the CSR as stipulated in the law no.40/2007 through business players’ interviews. Using the semi structured  interviews with Indonesian executives/informants of Indonesian companies, this study found that CSR practices have been viewed as philanthropic activities of companies with all the consequences that follow: shareholder as the most important stakeholder, reporting CSR practice as means to have public image and no need to have any standard to prepare CSR practice reporting. Given the findings, there is a need to redefine CSR based on the intention to maintain good relationship with stakeholders and to have the integrated management system to help management well interact with them in market and non- market mechanism.

  13. Conceptions of CSR in management education

    DEFF Research Database (Denmark)

    Lystbæk, Christian Tang

    in management education policies, programs and practices. The aim of this paper is to make a first contribution to a critical analysis of the conceptions of CSR in management education policy. Based on a qualitative deconstructive analysis of management education policies, the paper identifies three main...... conceptions of CSR in management education policy and discusses their implications; a narrow economic conception of CSR, a broader economic conception of CSR and an all-encompassing systemic conception of CSR....... policy instruments used to promote CSR have been regulation, market-based instruments and voluntary agreements, but in recent years, policies have started to focus on education. Many different actors, such as business schools, businesses and governments, interact in shaping management education...

  14. Reflexive regulation of CSR to promote sustainablility

    DEFF Research Database (Denmark)

    Buhmann, Karin

    This article discusses Corporate Social Responsibility (CSR) from the perspective of governmental regulation as a measure to promote public policy interests through public-private regulation intended to influence firms’ self-regulation. Presenting a ‘government case’ for CSR, the connection between...... and the EU CSR Alliance. Focusing on human rights based in international law, it analyses the patterns of negotiation in the MSF and the background for the launch of the CSR Alliance. It shows that analysing public-private regulation of CSR from the perspective of reflexive law theory assists us...... in understanding the mechanisms by which public authorities seek to influence firm’s behaviour through CSR in order to promote public policy objectives. The analysis indicates that to be effective, reflexive regulatory approaches to public-private regulation should pay careful attention to procedural design...

  15. Reflexive regulation of CSR to promote sustainablility

    DEFF Research Database (Denmark)

    Buhmann, Karin

    climate change and environmental sustainability, and social, economic and other human rights lend human rights as part of CSR a potential for meeting some environmental and climate concerns and handling adverse side-effects. The article analyses two EU initiatives: The EU Multi-Stakeholder (MSF) on CSR...... in promoting companies’ responsibility with regard to aspects of sustainable development, such as climate impact. Keywords: Sustainable development, sustainable companies, reflexive regulation, climate change, CSR, EU law, public-private regulation, companies' self-regulation...... and the EU CSR Alliance. Focusing on human rights based in international law, it analyses the patterns of negotiation in the MSF and the background for the launch of the CSR Alliance. It shows that analysing public-private regulation of CSR from the perspective of reflexive law theory assists us...

  16. CSR Impedance for Non-Ultrarelativistic Beams

    Energy Technology Data Exchange (ETDEWEB)

    Li, Rui [Jefferson Lab., Newport News, VA (United States); Tsai, Cheng Y. [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Jefferson Lab., Newport News, VA (United States)

    2015-09-01

    For the analysis of the coherent synchrotron radiation (CSR)-induced microbunching gain in the low energy regime, such as when a high-brightness electron beam is transported through a low-energy merger in an energy-recovery linac (ERL) design, it is necessary to extend the CSR impedance expression in the ultrarelativistic limit to the non-ultrarelativistic regime. This paper presents our analysis of CSR impedance for general beam energies.

  17. CSR: FOCUS ON EMPLOYEES. ITALIAN CASES.

    Directory of Open Access Journals (Sweden)

    Patrizia Gazzola

    2014-12-01

    Full Text Available The aim of the paper is to analyze the Corporate Social Responsibilitys (CSR influence on employees considering the fact that employees are primary stakeholders who directly contribute to the success of the company. CSR relates to employees helps to motivate the employees themselves. Job quality should be a key objective of any employer because the happy employees can create happy customers, which produce good business results. Research clearly indicates, with the help of statistical data and with the case study methodology, that committing to CSR boosts the morale and commitment of workers in a positive way. Employees who are satisfied with the organization s commitment to social and environmental responsibilities demonstrate more commitment, engagement and productivity. A conceptual framework is proposed based on literature. The author predominantly uses methods of qualitative research. In the research the case study methodology, which has been developed within the social sciences, is used. The paper starts with a concise introduction of CSR. In the first part the potential impact of CSR on employees is explained, considering why CSR may represent a special opportunity to positively influence employees’ and prospective employees’ perceptions of companies. In the second part the research considers three Italian companies that have distinguished themselves for their CSR strategy for employees: Luxottica, Brunello Cucinelli and Ferrero. A growing number of studies have been done regarding the benefits of CSR. However, most are concerned with the external view of shareholders and customer perspective. CSR research on the employee level is not well developed now. In order to better understand its effect on the employees, this study explore the impact of employees' perception of CSR on subsequent work attitudes and behaviors. CSR has a significant effect and it could improve employees' attitudes and behaviors, contribute to corporations' success

  18. China’s CSR Has Both Common and Unique Dimensions as Compared with Western CSR

    Institute of Scientific and Technical Information of China (English)

    徐尚昆; 杨汝岱

    2008-01-01

    We conducted an inductive analysis of corporate social responsibility (CSR) in China based on an open-ended survey of 630 CEOs and business owners in 12 provinces and municipalities across China. In the survey, we collected 2811 CSR sample scenarios. After examining the quantitative data thus acquired, we identified 9 dimensions of CSR, including two dimensions never mentioned in western literature and another 2 dimensions generally recognized in western countries but not yet taking shape in China. A comparative study of CSR between China and western countries also unveiled some unique dimensions of CSR in China.In conclusion, CSR has been manifested in China in a form different from that in western countries, and China’s CSR is closely related to the social and cultural background of China.

  19. Integral Measurement of Dipole Prototype of CSR

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The dipole prototype is C type used as bending magnet of the injection beam line in CSR, and acts as a model of the dipoles in the CSR main ring simultaneously. The designed relative uniformity of good field is 0.001 in 100 mm width. The results of the local distribution and transfunction at transverse profile measured

  20. Towards strategic CSR in the multinational corporations

    DEFF Research Database (Denmark)

    Linneberg, Mai Skjøtt; Thorup-Jensen, Line

    2014-01-01

    CSR is a context-specific phenomenon, which makes working strategically with CSR particularly challenging for multinational corporation as it must allow for the various contexts of operation. Based on the extant literature, this article provides a conceptual presentation of MNC's opportunities...

  1. The Business Excellence Model for CSR Implementation?

    DEFF Research Database (Denmark)

    Neergaard, Peter; Gjerdrum Pedersen, Esben Rahbek

    2012-01-01

    Most of the Fortune 500 companies address Corporate Social Responsibility (CSR) on their websites. However, CSR remains a fluffy concept difficult to implement in organization. The European Business Excellence Model has since the introduction in 1992 served as a powerful tool for integrating qual...

  2. CSR Position in the Top Management Team

    DEFF Research Database (Denmark)

    Strand, Robert

    Recently, a number of positions with corporate social responsibility (CSR) in the position title have been introduced to the top management teams (TMTs) of some of the world’s largest corporations. I explore this phenomenon. I revisit 10 such positions identified in a previous study to add...... represents the “office holder” at the top of the corporation’s CSR bureaucracy....

  3. Industrial Clusters and CSR in Developing Countries

    DEFF Research Database (Denmark)

    Fayyaz, Anjum; Lund-Thomsen, Peter; Lindgreen, Adam

    2015-01-01

    This article contributes to literature on corporate social responsibility (CSR) exhibited by industrial clusters in developing countries. The authors conceptualize and empirically investigate the role of donor-funded CSR initiatives aimed at promoting collective action by cluster-based small- and......, tensions within SME networks, and negative perceptions of CSR by the cluster-based SMEs themselves. The findings and implications of this analysis can inform both research and policy making in this area......This article contributes to literature on corporate social responsibility (CSR) exhibited by industrial clusters in developing countries. The authors conceptualize and empirically investigate the role of donor-funded CSR initiatives aimed at promoting collective action by cluster-based small...

  4. Stakeholder involvement in CSR strategy-making?

    DEFF Research Database (Denmark)

    Trapp, Leila

    2014-01-01

    A given characteristic of successful corporate social responsibility (CSR) programs is that they reflect stakeholder expectations and preferences for corporate behavior. This study examines the process by which this alignment is sought by CSR managers in the CSR strategy-making process. Through...... reliance on stakeholder management theories, and with a particular focus on how and why managers communicate with stakeholders, the extent to which the company-stakeholder alignment process in CSR strategy-making reflects modern, enlightened approaches to stakeholder relations is assessed. This assessment...... is based on an analysis of structured, in-depth interviews with CSR managers from sixteen industry-leading, Danish companies. The managers’ descriptions of their interactions with stakeholders reveal that their practices fall short of the normative, theoretical ideals since their focus is primarily on just...

  5. CSR-communication in the Business Press

    DEFF Research Database (Denmark)

    Morsing, Mette; Langer, Roy

    In this paper we analyze the construction of corporate social responsibility in the business press as an act of strategic ambiguity. While corporate social responsibility (CSR) generally evokes positive associations in public opinion, this paper demonstrates that these associations are based...... on a broadly encompassing and ambiguous definition of CSR. Our empirical data shows how the business press in its discourse on CSR provides no clarity on the definition of CSR in terms of a coherent motive, a dominant stakeholder or a consistent issue, but rather maintains ambiguity and imprecision about...... is systematically maintained in the business press. We refer to this process as strategic ambiguity. The paper discusses the potential value and limitations of framing CSR in a state of strategic ambiguity in the context of the concurrent rethinking of the role of business in modern welfare societies....

  6. Industrial Clusters and CSR in Developing Countries

    DEFF Research Database (Denmark)

    Fayyaz, Anjum; Lund-Thomsen, Peter; Lindgreen, Adam

    2015-01-01

    This article contributes to literature on corporate social responsibility (CSR) exhibited by industrial clusters in developing countries. The authors conceptualize and empirically investigate the role of donor-funded CSR initiatives aimed at promoting collective action by cluster-based small- and......, tensions within SME networks, and negative perceptions of CSR by the cluster-based SMEs themselves. The findings and implications of this analysis can inform both research and policy making in this area......This article contributes to literature on corporate social responsibility (CSR) exhibited by industrial clusters in developing countries. The authors conceptualize and empirically investigate the role of donor-funded CSR initiatives aimed at promoting collective action by cluster-based small......- and medium-sized enterprises (SMEs). A case study of the Sialkot football-manufacturing cluster in Pakistan indicates that donor-funded support of CSR initiatives in industrial clusters in developing countries may be short-lived, due to the political economy of aid, the national context of CSR implementation...

  7. CONDITIONS FOR CSR MICROBUNCHING GAIN SUPPRESSION

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, Cheng Ying [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Douglas, David R. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Li, Rui [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Tennant, Christopher D. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); di Mitri, Simone [Elettra–Sincrotrone Trieste, 34149 Basovizza, Trieste, Italy

    2016-05-01

    The coherent synchrotron radiation (CSR) of a high brightness electron beam traversing a series of dipoles, such as transport arcs, may result in phase space degradation. On one hand, the CSR can perturb electron transverse motion in dispersive regions along the beamline, causing emittance growth. On the other hand, the CSR effect on the longitudinal beam dynamics could result in microbunching gain enhancement. For transport arcs, several schemes have been proposed* to suppress the CSR-induced emittance growth. Similarly, several scenarios have been introduced** to suppress CSR-induced microbunching gain, which however mostly aim for linac-based machines. In this paper we try to provide sufficient conditions for suppression of CSR-induced microbunching gain along a transport arc, analogous to*. Several example lattices are presented, with the relevant microbunching analyses carried out by our semi-analytical Vlasov solver***. The simulation results show that lattices satisfying the proposed conditions indeed have microbunching gain suppressed. We expect this analysis can shed light on lattice design approach that could suppress the CSR-induced microbunching gain.

  8. THE IMPORTANCE OF CSR IMPLEMENTATION

    Directory of Open Access Journals (Sweden)

    Anna Križanová

    2016-09-01

    Full Text Available The last three decades of the twentieth century and the beginning of the twenty-first century were marked by the expansion of managerial ethics and social responsibility of business. Business ceased to be perceived in terms of profit being the sole interest of management, and ethical aspects were stressed more so in connection with the company’s management. Specific managerial ethical initiatives and activities leading from outside and inside the organization constitutes the concept of Corporate Social Responsibility (CSR, which comprises many factors. The aim of this paper is to summarize the positive impact of corporate social responsibility for business activities using secondary data from global surveys and then confirm the importance and benefits of corporate social responsibility for enterprises in the Slovak Republic using primary data.

  9. Breaking through the self-fulfilling prophecy of CSR

    NARCIS (Netherlands)

    Nijhof, A.H.J.; Zwart, van der A.; Jonker, J.

    2009-01-01

    Since the last decades of the twentieth century the debate on the concept of corporate social responsibility (CSR) intensified significantly. This debate concentrates on the meaning, impact and possible gains from CSR. Alongside the growing number of CSR advocates there are also a number of CSR crit

  10. Health survey on cancers about the Tricastin nuclear site; Etude sanitaire sur les cancers autour du site nucleaire du Tricastin

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This survey aims at describing the health status of the population around the Tricastin site, and more particularly at determining whether there is a difference between death or cancer occurrence frequencies observed around this site with respect to reference frequencies. It does not aim at assessing the health impact of the site industrial installations. Cancer mortality data, cancer diagnosis data, demographic data, child cancer data, data related to hospital stays in relationship with cancer, long duration hospital stay data, and mortality data are used. Several indicators are defined and used: standardised mortality ratio, standardised hospitalisation ratio. Data are also analysed in terms of location, and socio-demographic categories. It appears that there is no specific health situation for the considered area, except for pancreas cancer for women

  11. Incorporating other texts: Intertextuality in Malaysian CSR reports

    OpenAIRE

    Kumaran Rajandran

    2016-01-01

    In Malaysia, corporate social responsibility (CSR) is relatively new but corporations have been required to engage in and disclose their CSR. A typical genre for disclosure is CSR reports and these reports often refer to other texts. The article investigates the act of referencing to other texts or intertextuality in Malaysian CSR reports. It creates an archive of CEO Statements and Environment Sections in CSR reports and studies the archive for keywords, which can identify the incorporated ...

  12. The Economic Virtues of SRI and CSR

    NARCIS (Netherlands)

    J. Derwall (Jeroen)

    2007-01-01

    textabstractFinancial markets and company managers are increasingly acknowledging the concepts of socially responsible investing (SRI) and corporate social responsibility (CSR), but not without reservations. These hesitations are largely attributable to ongoing debates about a potential conflict bet

  13. CSR REPORTING IN BANKS - THE ROMANIAN EVIDENCE

    Directory of Open Access Journals (Sweden)

    Georgiana-Loredana FRECEA

    2016-06-01

    Full Text Available The dynamics of the financial markets and the significant interrelationships with broader concepts as globalization or sustainable development, have led in recent years to the development of a multidimensional approach of CSR. The credibility of the financial system is based on the financial institutions image given by representative stakeholders. They filter in an objective way the ethical responsibilities of the banks and the legal ones and give them the legitimacy to operate on the market. In order to obtain a realistic framework of CSR in Romanian banks, the article will focus on the transparency of CSR information. The confidence crisis manifested in the banking institutions can best be overcome through an authentic reporting system, which is able to fulfill a set of requirements, from credibility to completeness. This paper highlights the main characteristics of the CSR reports provided by the Romanian banking institutions, based on the stakeholder theory and using international reporting frameworks as Global Reporting Initiative.

  14. Managing Projects with CSR in mind

    DEFF Research Database (Denmark)

    Kampf, Constance; Thomsen, Christa

    2008-01-01

    This paper examines project management as a place where CSR can be operationalized, focusing particularly on project conception processes and co-constructing CSR knowledge with emergent tertiary stakeholders. Two projects which dealt with emergent tertiary stakeholders differently are examined.......  First, the Finnish company Metsa-Botnia's paper pulp plant in Uruguay is examined as a project in which a tertiary stakeholder, Argentina, emerged during the early stages of the project.  Argentina requested dialogue about the project conception and Metsa Botnia did not include them.  In contrast......, the Danish emergency services company Falck A/S's project on redefining CSR is offered as an example of a project transformed through dialogue with the emergent tertiary stakeholder, the county of Aarhus.   To analyze the cases, the paper combines Morsing & Schultz's (2006) dialectic CSR strategy based...

  15. The C.S.R. implementation

    Directory of Open Access Journals (Sweden)

    Mihaela Bucur

    2014-12-01

    Full Text Available The enterprises which started to integrate the principles of sustainable development in their activity, in their business processes and in their philosophy of business unfolding, require that Corporate Social Responsibility (CSR actions held by the companies involved a significant component of sustainable development. In practice, it would be beneficial if every direct action of the enterprise achieved long-lasting objectives and obtained sustainable results. The original contribution of this work is therefore essential for practitioners because it identifies a series of steps to be followed for the implementation and evaluation of a company's CSR activities. The present research addresses the need for implementing the concept of CSR in up companies. Our approach is drawn from several theoretical models, simplified for a beginner integrating CSR programs. Thus, in order to know what to start with, we have identified a number of simple steps and a methodology presented in this article.

  16. SMEs and CSR in Developing Countries

    DEFF Research Database (Denmark)

    Jamali, Dima; Lund-Thomsen, Peter; Jeppesen, Søren

    2017-01-01

    This article is the guest editors’ introduction to the special issue in Business & Society on “SMEs and CSR in Developing Countries.” The special issue includes four original research articles by Hamann, Smith, Tashman, and Marshall; Allet; Egels-Zandén; and Puppim de Oliveira and Jabbour...... on various aspects of the relationship of small and medium enterprises (SMEs) to corporate social responsibility (CSR) in developing countries....

  17. The Cryogenic Storage Ring CSR

    CERN Document Server

    von Hahn, Robert; Berg, Felix; Blaum, Klaus; Breitenfeldt, Christian; Fadil, Hisham; Fellenberger, Florian; Froese, Michael; George, Sebastian; Göck, Jürgen; Grieser, Manfred; Grussie, Florian; Guerin, Elisabeth A; Heber, Oded; Herwig, Philipp; Karthein, Jonas; Krantz, Claude; Kreckel, Holger; Lange, Michael; Laux, Felix; Lohmann, Svenja; Menk, Sebastian; Meyer, Christian; Mishra, Preeti M; Novotný, Oldřich; Connor, Aodh P O; Orlov, Dmitry A; Rappaport, Michael L; Repnow, Roland; Saurabh, Sunny; Schippers, Stefan; Schröter, Claus Dieter; Schwalm, Dirk; Schweikhard, Lutz; Sieber, Thomas; Shornikov, Andrey; Spruck, Kaija; Kumar, Sudhakaran Sunil; Ullrich, Joachim; Urbain, Xavier; Vogel, Stephen; Wilhelm, Patrick; Wolf, Andreas; Zajfman, Daniel

    2016-01-01

    An electrostatic cryogenic storage ring, CSR, for beams of anions and cations with up to 300 keV kinetic energy per unit charge has been designed, constructed and put into operation. With a circumference of 35 m, the ion-beam vacuum chambers and all beam optics are in a cryostat and cooled by a closed-cycle liquid helium system. At temperatures as low as (5.5 $\\pm$ 1) K inside the ring, storage time constants of several minutes up to almost an hour were observed for atomic and molecular, anion and cation beams at an energy of 60 keV. The ion-beam intensity, energy-dependent closed-orbit shifts (dispersion) and the focusing properties of the machine were studied by a system of capacitive pickups. The Schottky-noise spectrum of the stored ions revealed a broadening of the momentum distribution on a time scale of 1000 s. Photodetachment of stored anions was used in the beam lifetime measurements. The detachment rate by anion collisions with residual-gas molecules was found to be extremely low. A residual-gas den...

  18. The cryogenic storage ring CSR

    Science.gov (United States)

    von Hahn, R.; Becker, A.; Berg, F.; Blaum, K.; Breitenfeldt, C.; Fadil, H.; Fellenberger, F.; Froese, M.; George, S.; Göck, J.; Grieser, M.; Grussie, F.; Guerin, E. A.; Heber, O.; Herwig, P.; Karthein, J.; Krantz, C.; Kreckel, H.; Lange, M.; Laux, F.; Lohmann, S.; Menk, S.; Meyer, C.; Mishra, P. M.; Novotný, O.; O'Connor, A. P.; Orlov, D. A.; Rappaport, M. L.; Repnow, R.; Saurabh, S.; Schippers, S.; Schröter, C. D.; Schwalm, D.; Schweikhard, L.; Sieber, T.; Shornikov, A.; Spruck, K.; Sunil Kumar, S.; Ullrich, J.; Urbain, X.; Vogel, S.; Wilhelm, P.; Wolf, A.; Zajfman, D.

    2016-06-01

    An electrostatic cryogenic storage ring, CSR, for beams of anions and cations with up to 300 keV kinetic energy per unit charge has been designed, constructed, and put into operation. With a circumference of 35 m, the ion-beam vacuum chambers and all beam optics are in a cryostat and cooled by a closed-cycle liquid helium system. At temperatures as low as (5.5 ± 1) K inside the ring, storage time constants of several minutes up to almost an hour were observed for atomic and molecular, anion and cation beams at an energy of 60 keV. The ion-beam intensity, energy-dependent closed-orbit shifts (dispersion), and the focusing properties of the machine were studied by a system of capacitive pickups. The Schottky-noise spectrum of the stored ions revealed a broadening of the momentum distribution on a time scale of 1000 s. Photodetachment of stored anions was used in the beam lifetime measurements. The detachment rate by anion collisions with residual-gas molecules was found to be extremely low. A residual-gas density below 140 cm-3 is derived, equivalent to a room-temperature pressure below 10-14 mbar. Fast atomic, molecular, and cluster ion beams stored for long periods of time in a cryogenic environment will allow experiments on collision- and radiation-induced fragmentation processes of ions in known internal quantum states with merged and crossed photon and particle beams.

  19. CSR and aging workforces: An explorative study on CSR-implementation in SMEs

    NARCIS (Netherlands)

    Gellert , J. F.; De Graaf, J. F.

    2012-01-01

    Although critical differences exist between large companies and small- and medium-sized enterprises (SMEs), limited empirical research has been done on human resource (HR)-related corporate social responsibility (CSR). In this paper we study aging workforce management (AWM) as a component of CSR. Ou

  20. IMPLICATIONS OF CSR ON CORPORATE STAKEHOLDERS

    Directory of Open Access Journals (Sweden)

    Crisan Catalina

    2015-07-01

    Full Text Available Companies’ strategies and values must be in accordance to stakeholders’ expectations and needs because their role and influences on companies’ activity are decisive for companies future development. Corporate Social Responsibility is a meaningful way through which companies can pursue sustainable development by having a coherent economical, social and environmental perspective on how the business should be managed. CSR must become an integral part of corporate management system, because it has a major role in distressing the relation between company and major stakeholders, both internally and externally. CSR is a global phenomenon, which draws the attention of a growing number of partisans, from public private and social sector. To demonstrate the applicability of the theoretical approaches deduced from the existing literature, the authors recourse to an empirical qualitative research, conducted through a questionnaire implemented to top managers, HR managers and heads of CSR departments within large companies that operate in Romania. The research is based on the analysis of a number of 87 questionnaires and aims to highlight major stakeholders and finding how companies’ responsible activities can influence stakeholders. This study is designed to highlight how prioritization of stakeholders influences CSR initiatives within large companies that operate in Romania, and to present a perspective of company’s approach towards shared value influence major stakeholders. The conclusions drawn have a greater relevance both theoretically and especially practically because provides insights on how large companies perceive CSR and how stakeholders influence responsible initiatives in emergent country like Romania where stereotypes are difficult to manage.

  1. Circuitry linking the Csr and stringent response global regulatory systems.

    Science.gov (United States)

    Edwards, Adrianne N; Patterson-Fortin, Laura M; Vakulskas, Christopher A; Mercante, Jeffrey W; Potrykus, Katarzyna; Vinella, Daniel; Camacho, Martha I; Fields, Joshua A; Thompson, Stuart A; Georgellis, Dimitris; Cashel, Michael; Babitzke, Paul; Romeo, Tony

    2011-06-01

    CsrA protein regulates important cellular processes by binding to target mRNAs and altering their translation and/or stability. In Escherichia coli, CsrA binds to sRNAs, CsrB and CsrC, which sequester CsrA and antagonize its activity. Here, mRNAs for relA, spoT and dksA of the stringent response system were found among 721 different transcripts that copurified with CsrA. Many of the transcripts that copurified with CsrA were previously determined to respond to ppGpp and/or DksA. We examined multiple regulatory interactions between the Csr and stringent response systems. Most importantly, DksA and ppGpp robustly activated csrB/C transcription (10-fold), while they modestly activated csrA expression. We propose that CsrA-mediated regulation is relieved during the stringent response. Gel shift assays confirmed high affinity binding of CsrA to relA mRNA leader and weaker interactions with dksA and spoT. Reporter fusions, qRT-PCR and immunoblotting showed that CsrA repressed relA expression, and (p)ppGpp accumulation during stringent response was enhanced in a csrA mutant. CsrA had modest to negligible effects on dksA and spoT expression. Transcription of dksA was negatively autoregulated via a feedback loop that tended to mask CsrA effects. We propose that the Csr system fine-tunes the stringent response and discuss biological implications of the composite circuitry.

  2. Cancer registries in Japan: National Clinical Database and site-specific cancer registries.

    Science.gov (United States)

    Anazawa, Takayuki; Miyata, Hiroaki; Gotoh, Mitsukazu

    2015-02-01

    The cancer registry is an essential part of any rational program of evidence-based cancer control. The cancer control program is required to strategize in a systematic and impartial manner and efficiently utilize limited resources. In Japan, the National Clinical Database (NCD) was launched in 2010. It is a nationwide prospective registry linked to various types of board certification systems regarding surgery. The NCD is a nationally validated database using web-based data collection software; it is risk adjusted and outcome based to improve the quality of surgical care. The NCD generalizes site-specific cancer registries by taking advantage of their excellent organizing ability. Some site-specific cancer registries, including pancreatic, breast, and liver cancer registries have already been combined with the NCD. Cooperation between the NCD and site-specific cancer registries can establish a valuable platform to develop a cancer care plan in Japan. Furthermore, the prognosis information of cancer patients arranged using population-based and hospital-based cancer registries can help in efficient data accumulation on the NCD. International collaboration between Japan and the USA has recently started and is expected to provide global benchmarking and to allow a valuable comparison of cancer treatment practices between countries using nationwide cancer registries in the future. Clinical research and evidence-based policy recommendation based on accurate data from the nationwide database may positively impact the public.

  3. Security of Operation on CSR Control System

    Institute of Scientific and Technical Information of China (English)

    GouShizhe; QiaoWeimin; JingLan

    2003-01-01

    It is important to the security of operation on the CSR control system. In order to keep the CSR control system in security environment, the following work has been done. Firstly, it can be set up a domain service, and every important services can join in it, such as databasese rvices, front web services and every interactive operating browsers, and limited the browsers right by using policy of the domain. After this, the browsers can't modify the setting of the browser, and it can keep every computers and browsers in security by preventing some virus into each computer. The domain services of control system is shown in Fig.1.

  4. A Public Governance Look at CSR

    DEFF Research Database (Denmark)

    Buhmann, Karin

    2014-01-01

    interesting potential for public regulators to steer private/public-private resource exploitation towards increased contributions to public sustainability and welfare state objectives. The significance of CSR policies and practices as private governance modalities towards risk management and as competition...... parameters combine with normative guidance based on CSR norms (e.g. the UN Global Compact, OECD’s Guidelines for Multinational Enterprises, the UN Guidelines on Business and Human Rights). Focusing on debates concerning resource extraction operations in Greenland and the pertinent policy framework...

  5. DETERMINAN PENGUNGKAPAN CSR DAN LEGITIMASI PERBANKAN SYARIAH

    Directory of Open Access Journals (Sweden)

    Adi Susilo Jahja

    2016-06-01

    Full Text Available The existence of organisation can be determined by its legitimacy. Legitimacy theory stated that the organisation should in line with the values and norms of its stakeholders. Indonesia Islamic banking legitimacy is important since this industry in Indonesia is still have small market share, but Indonesia Financial Authority (OJK has commitment to enhance the contribution of this industry to the Indonesian development. Conceptually, legitimacy could be hanced by Corporate Social Responsibility (CSR disclosure, while CSR disclosure is determined by company visibility, profitability, company size, and ownership structure.

  6. CSR Institutionalized Myths in Developing Countries

    DEFF Research Database (Denmark)

    Jamali, Dima; Lund-Thomsen, Peter; Khara, Navjote

    2017-01-01

    and standards. Through empirical fieldwork in the football manufacturing industry of Jalandhar in North India, the article documents how local cluster-based SMEs stay coupled with the global CSR agenda through joint CSR initiatives focusing on child labor. Probing further, however, also reveals patterns...... of selective decoupling in relation to core humanitarian and labor rights issues. Through in-depth interviews with a wide range of stakeholders involved in the export-oriented football manufacturing industry of Jalandhar in North India, the article highlights the dynamics of coupling and decoupling taking...

  7. Liberal CSR and New Marxist Criticism

    DEFF Research Database (Denmark)

    Toft, Kristian Høyer

    2014-01-01

    The term ‘corporate social responsibility’ (CSR) is considered by the new Marxist left to be a self-defeating oxymoron. In this chapter, the new Marxist challenge to CSR as a meaningful, coherent concept and practice is discussed. In the wake of the financial crisis the critique from the Marxist......, this chapter introduces the Hegelian inspired critique of a New Spirit of Capitalism (Chiapello 2013) as well as the critique of ideology targeted at the neo-liberal project of corporate responsibility (Žižek 2008; Fleming and Jones 2013). Subsequently, two possible liberal ‘revisions’ to the Marxist inspired...

  8. Consumer perceptions of CSR: (how) is China different?

    OpenAIRE

    van der Kolk, A; van Dolen, W.; MA, L.

    2015-01-01

    Purpose Most studies on consumers and corporate social responsibility (CSR) have focused on Western contexts. Consequently, good insight is lacking into non-Western markets where consumers may respond differently. China is a case in point, despite the popularity of the CSR concept and high societal expectations of firms. The purpose of this paper is to examine how Chinese consumers perceive the underlying components of CSR found in Western countries; whether their CSR expectations differ for ...

  9. Atopy and Specific Cancer Sites: a Review of Epidemiological Studies.

    Science.gov (United States)

    Cui, Yubao; Hill, Andrew W

    2016-12-01

    Mounting evidence appears to link asthma and atopy to cancer susceptibility. This review presents and discusses published epidemiological studies on the association between site-specific cancers and atopy. PubMed was searched electronically for publications between 1995 and 2015, and cited references were researched manually. Quantitative studies relating to atopy, allergy, or asthma and cancer were identified and tabulated. Despite many exposure-related limitations, patterns in the studies were observed. Asthma, specifically, has been observed to be a risk factor for lung cancer. A protective effect of atopic diseases against pancreatic cancer has been shown consistently in case-control studies but not in cohort studies. Allergy of any type appears to be protective against glioma and adult acute lymphoblastic leukemia. Most studies on atopic diseases and non-Hodgkin lymphoma or colorectal cancer reported an inverse association. The other sites identified had varying and non-significant outcomes. Further research should be dedicated to carefully defined exposure assessments of "atopy" as well as the biological plausibility in the association between atopic diseases and cancer.

  10. Nanshan Aluminum Reached Strategic Cooperation with CSR Corporation Limited

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    As a key supplier of aluminum profiles and aluminum plate,sheet and trip products for CSR Corporation Limited,Nanshan Aluminum will join hands with CSR Corporation Limited to reach strategic cooperation.On January 5,Nanshan Aluminum signed strategic cooperation agreement with CSR Sifang Locomotive&Rolling; Stock Co.,Ltd,both

  11. Implementation: Measuring and Explaining the Fidelity of CSR Implementation

    Science.gov (United States)

    Kurki, Anja; Boyle, Andrea; Aladjem, Daniel K.

    2006-01-01

    Comprehensive school reform (CSR) is only as effective as its implementation. By using data collected for the National Longitudinal Evaluation of Comprehensive School Reform (NLECSR), this article explores the factors that predict CSR model implementation and the ways that CSR model implementation varies. We found little difference in the fidelity…

  12. Primary site resection is superior for incurable metastatic colorectal cancer

    Institute of Scientific and Technical Information of China (English)

    Yusuke; Tanoue; Nobutaka; Tanaka; Yukihiro; Nomura

    2010-01-01

    AIM:To investigate survival in patients treated with FOLFOX followed by primary site resection or palliative surgery for incurable metastatic colorectal cancer. METHODS:Between 2001 and 2009,a total of 98 patients with colorectal adenocarcinoma and non-resectable metastases were diagnosed and treated with the new systemic agent chemotherapy regimen FOLFOX. Primary site resection was carried out in 38 patients, creation of a colostomy or bypass without resection was carried out in 36 patients,and 23 were not...

  13. How Personal Values Influence Romanian CSR Managers` Involvment in CSR Campaigns

    Directory of Open Access Journals (Sweden)

    Anca Diana ȘERBAN

    2015-12-01

    Full Text Available This study focuses on identifying the ratio between the individual and organization authority of CSR managers concerning decision making within the campaigns they coordinate. The sample includes the top 100 Romanian companies selected by turnover. The way in which the managers’ values interact with the organization authority is a subject treated poorly in both international and Romanian literature. This study, which has an exploratory character, investigates how personal values lead Romanian CSR managers to develop and coordonate CSR campaigns and to what extent these values are part of the campaign messages compared to the values of the company for which they are made. The main results of this scientific paper refers to the correlation between the CSR managers’ values and the campaigns that they coordinate.

  14. High Vacuum Furnace for HIRFL-CSR

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    In order to satisfy the requirement of ultra-high vacuum and low out-gassing rate of materials which are used to make HIIRFL-CSR vacuum chambers, a high vacuum furnace for degassing the beam chambers, flanges, and the other vacuum components has been designed and manufactured by IMP and Vacuum Equipment Factory in Lanzhou.

  15. CSR in the Aftermath of the Financial Crisis

    DEFF Research Database (Denmark)

    Lauesen, Linne Marie

    2013-01-01

    Purpose – The purpose of this paper is to examine the literature of CSR before and in the aftermath of the financial crisis in 2008. The aim of the research question is to map out the consequences upon CSR derived from the crisis and to derive new principles of future CSR models to come consistent...... the financial crisis 2008, with an emphasis on academic papers published in peer-reviewed journals. Findings – The findings of the paper reveal that post-crisis CSR-models do not articulate anything that has not been mentioned before; however, they do strengthen former values of CSR, but still lack an overall...... formula of how the financial sector can adopt CSR in the core of their businesses, and transparently display their products, and the risk adhering to them. The paper proposes a new Four-“E”-Principle that may guide new CSR-models to accomplish this deficit. See under “Originality”. Practical implications...

  16. Reviewing CSR management and marketing communication research: A discourse approach

    DEFF Research Database (Denmark)

    Nielsen, Anne Ellerup; Thomsen, Christa

    To judge from the rapidly growing body of research in the field of corporate social responsibility (CSR) management and marketing communication, there is an increasing interest in exploring the role of communication along with the transmission from implicit towards explicit CSR in the European......, and act on them through different CSR communication initiatives, channels and technology, e.g. mass media and social media. However, in spite of the growing attention on adopting CSR communication strategies and tactics, there does not seem to be a common understanding and consensus of how and to which...... of CSR research. The purpose of this investigation is to analyze how the role of communication and interaction is conceptualized in specific social contexts such as managing and marketing corporations through CSR. Many researchers argue that CSR communication is likely to increase stakeholder engagement...

  17. Highly efficient site-specific transgenesis in cancer cell lines

    Directory of Open Access Journals (Sweden)

    Michael Iacovos P

    2012-12-01

    Full Text Available Abstract Background Transgenes introduced into cancer cell lines serve as powerful tools for identification of genes involved in cancer. However, the random nature of genomic integration site of a transgene highly influences the fidelity, reliability and level of its expression. In order to alleviate this bottleneck, we characterized the potential utility of a novel PhiC31 integrase-mediated site-specific insertion system (PhiC31-IMSI for introduction of transgenes into a pre-inserted docking site in the genome of cancer cells. Methods According to this system, a “docking-site” was first randomly inserted into human cancer cell lines and clones with a single copy were selected. Subsequently, an “incoming” vector containing the gene of interest was specifically inserted in the docking-site using PhiC31. Results Using the Pc-3 and SKOV-3 cancer cell lines, we showed that transgene insertion is reproducible and reliable. Furthermore, the selection system ensured that all surviving stable transgenic lines harbored the correct integration site. We demonstrated that the expression levels of reporter genes, such as green fluorescent protein and luciferase, from the same locus were comparable among sister, isogenic clones. Using in vivo xenograft studies, we showed that the genetically altered cancer cell lines retain the properties of the parental line. To achieve temporal control of transgene expression, we coupled our insertion strategy with the doxycycline inducible system and demonstrated tight regulation of the expression of the antiangiogenic molecule sFlt-1-Fc in Pc-3 cells. Furthermore, we introduced the luciferase gene into the insertion cassette allowing for possible live imaging of cancer cells in transplantation assays. We also generated a series of Gateway cloning-compatible intermediate cassettes ready for high-throughput cloning of transgenes and demonstrated that PhiC31-IMSI can be achieved in a high throughput 96-well plate

  18. Comparison analysis between CSR-OT and CSR-H for corrugated bulkhead of large product tankers

    Institute of Scientific and Technical Information of China (English)

    蔡诗剑; 邱伟强; 刘奕谦

    2014-01-01

    Large Aframax product tanker (more than 100k DWT), with centerline longitudinal corrugated bulkheads and transverse corrugated bulkheads in cargo area, is the largest type of product tanker at present. The external draft of Harmonized Common Structural Rules (CSR-H) for Bulk Carriers and Oil Tankers is released for external review. More attentions are paid to the impact of CSR-H on the structural design of the corrugated bulkhead of large Aframax product tankers. Based on CSR-OT and CSR-H, it discusses the impact of CSR-H on the corrugated bulkhead by strength assessment of a 115k DWT product tanker.

  19. Corporate Social Performance of Indian FMCG Companies Introduction of CSR, framework and Karmayog CSR Ratings with three top Indian FMCG companies CSR initiatives

    Directory of Open Access Journals (Sweden)

    Saeed Khan

    2009-12-01

    materials, these companies are doing work in the field of Environment, Health care, Education, Community welfare, Women's empowerment and Girl Child care. Companies like Hindustan Unilever started work on CO2 reduction also. The websites of these companies are providing information about their CSR initiatives but are found not updated regularly. For checking their CSR performance, Karmayog Rating is taken. The rating gives good insight on CSR ratings of major FMCG companies of India. The method of calculating the rating also discussed. In appendices, India‘s top three major FMCGs companies overall CSR initiatives are discussed.

  20. The Current State of CSR Consultancy Development in Russia and the United Kingdom

    OpenAIRE

    Armley, Natasha

    2005-01-01

    The research examines the phenomenon of corporate social responsibility (CSR) consultancy in Russia, as a new growing market, in comparison with well defined CSR consultancy in the UK, more advanced in CSR traditions and practices. The introduction to CSR consultancy has been made through a prism of CSR definitions: how it is interpreted in the West and Russia. Significant attention has been paid to analysing the UK and Russia national CSR systems combining the major drivers of CSR develo...

  1. Magnitude and Leading Sites of Cancer in A Tertiary Cancer Care Hospital of Western Maharashtra

    Directory of Open Access Journals (Sweden)

    Kapil H Agrawal, S.S. Rajderkar

    2011-01-01

    Full Text Available Context: It is observed that cancers are increasingly seen in both genders and all the age groups due to a complex interaction of various risk factors. To implement the Public health intervention measures it is essential to have the baseline data regarding frequency, distribution of cancers in the population. Aims: To study the magnitude of cancers by obtaining a baseline data regarding the frequency, distribution, leading cancer sites among the patients in a tertiary cancer care hospital of Western Maharashtra. Study settings: Shri Siddhivinayak Ganapati Cancer Hospital, Miraj Study Design: Hospital based, Cross sectional study involving retrospective information of patients from 1st March 2005 to 28th February 2006. Methods and Material: Retrospective, questionnaire study of patients from 1st March 2005 to 28th February 2006. Out of the total 2168 new patients registered, 1891 patients were detected to be malignant and included in the study. Results: 63.5 % Males and 67% Females in the age group 35-64 years had cancer. The sex ratio percent was 1.01%. Top five Cancer in males in our study were Oral Cavity, Oesophagus, Lung, Larynx and NHL. Top five Cancer in females in our study were Cervix, Breast, Ovary, Oral Cavity and Oesophagus. 27% were TRCs (Tobacco Related Cancers in males while 9.6% were TRCs in females. 34% cancers were in easily accessible parts of body. Conclusions: The Tobacco Related Cancers represent the most preventable form of cancer in our society. It was 27% in males and 9.6% in females in our study. Additionally 34% cancers were in easily accessible parts of body. It highlights the possibility of easy and early detection of cancers in the population thus decreasing the cancer burden in the community.

  2. Incorporating other texts: Intertextuality in Malaysian CSR reports

    Directory of Open Access Journals (Sweden)

    Kumaran Rajandran

    2016-11-01

    Full Text Available In Malaysia, corporate social responsibility (CSR is relatively new but corporations have been required to engage in and disclose their CSR. A typical genre for disclosure is CSR reports and these reports often refer to other texts. The article investigates the act of referencing to other texts or intertextuality in Malaysian CSR reports. It creates an archive of CEO Statements and Environment Sections in CSR reports and studies the archive for keywords, which can identify the incorporated texts. The function of these texts is examined in relation to Malaysia’s corporate context. CSR reports contain explicit references to documents (policies, regulations, reports, research, standards and to individuals/groups (CEOs, stakeholders, expert organizations. The incorporated texts display variation in corporate control, which organizes these texts along an intertextual cline. The cline helps to identify corporate and non-corporate sources among the texts. The selection of incorporated texts may reflect government and stock exchange demands. The texts are not standardized and are relevant for the CSR domain and corporations, where these texts monitor and justify CSR performance. Yet, the incorporated texts may perpetuate inexact reporting because corporations select the texts and the parts of texts to refer to. Since these texts have been employed to scrutinize initiatives and results, CSR reports can claim to represent the “truth” about a corporation’s CSR. Hence, intertextuality serves corporate interests.

  3. Welfare mix, CSR and social citizenship

    OpenAIRE

    Moreno Fernández, Luis

    2010-01-01

    Corporate Social Responsibility (CSR) is an important undertaking by corporations in order to advance social citizenship. In the last decades a growing implication of businesses and NGOs in welfare development has run hand in hand with a noticeable increase of both: (a) the for-profit welfare provision of policies and services to the general public, and (b) those programmes made available by corporations to their employees. All these developments, together with the provision of social poli...

  4. Empowering the society through companies CSR agenda

    Directory of Open Access Journals (Sweden)

    Sulaiman Noor Adwa

    2017-01-01

    Full Text Available Topic of socioeconomic issue is one of the most widely discussed globally as it gives effects to occupation, education, income, wealth, and place of residence of individuals. These social challenges should be addressed and resolved because to enhance individuals’ contribution to economic and social life of their society and reduce social tensions and conflicts that negatively affects country’s economic development. For this reason, in the Eleventh Malaysia Plan (2016-2020, the Malaysian Government stresses on the importance of participation of companies in empowering society to improve socioeconomic that could support equitable society. The empowerment programs aim to improve the education, quality of life and wellbeing of individuals and groups in society through reducing wealth gap, racial imbalance and promoting employment equity. One way to initiate greater involvement of the companies in socioeconomic development of the society is through CSR agenda. Specifically, the CSR agenda through empowerment activities (such as trainings programs, educational sponsorship mentorship program and learning and development programs is believed to have a positive implication on society by way of improving wealth, education and skills of the individuals. Hence, this paper aims to develop measurement of empowerment in companies CSR agenda.

  5. An in-depth map of polyadenylation sites in cancer.

    Science.gov (United States)

    Lin, Yuefeng; Li, Zhihua; Ozsolak, Fatih; Kim, Sang Woo; Arango-Argoty, Gustavo; Liu, Teresa T; Tenenbaum, Scott A; Bailey, Timothy; Monaghan, A Paula; Milos, Patrice M; John, Bino

    2012-09-01

    We present a comprehensive map of over 1 million polyadenylation sites and quantify their usage in major cancers and tumor cell lines using direct RNA sequencing. We built the Expression and Polyadenylation Database to enable the visualization of the polyadenylation maps in various cancers and to facilitate the discovery of novel genes and gene isoforms that are potentially important to tumorigenesis. Analyses of polyadenylation sites indicate that a large fraction (∼30%) of mRNAs contain alternative polyadenylation sites in their 3' untranslated regions, independent of the cell type. The shortest 3' untranslated region isoforms are preferentially upregulated in cancer tissues, genome-wide. Candidate targets of alternative polyadenylation-mediated upregulation of short isoforms include POLR2K, and signaling cascades of cell-cell and cell-extracellular matrix contact, particularly involving regulators of Rho GTPases. Polyadenylation maps also helped to improve 3' untranslated region annotations and identify candidate regulatory marks such as sequence motifs, H3K36Me3 and Pabpc1 that are isoform dependent and occur in a position-specific manner. In summary, these results highlight the need to go beyond monitoring only the cumulative transcript levels for a gene, to separately analysing the expression of its RNA isoforms.

  6. CSR Driven Brand Marketing: The Case of Toms

    OpenAIRE

    Mensah, Doris

    2016-01-01

    This research investigates the concept of Corporate Social Responsibility and Branding and how organizations can integrate CSR initiatives with strategic brand management. The project analyzed and discussed Toms Group CSR activities in West Africa more especially in Ghana in relation to child labor and the conditions of cocoa farmers and what the company is doing in terms of CSR strategy that can benefit the brand of the company. The study empirically made semi-structured interviews with t...

  7. CSR and market changing product innovations: Indian case studies

    OpenAIRE

    Ramani, S.V.; Mukherjee, V.

    2010-01-01

    Do firms need to sacrifice profit while innovating in order to further social objectives, as corporate social responsibility (CSR) would seem to suggest? To answer this question, the paper compiles a classification of innovations according to market impact and CSR potential. Then it details case studies of two market changing (MC) innovations in India: genetically modified cotton of Monsanto and a drugs cocktail for HIV/AIDS of Cipla. It demonstrates that the CSR potential of an MC innovation...

  8. Fashionline: CSR case of a UK fashion retailer

    OpenAIRE

    Khan, Nadeem; Kakabadse, Nada K.; Kaur, Kulwinder

    2015-01-01

    This paper presents findings from a corporate social responsibility (CSR) case-study of a UK fashion retailer informed through 22 multi-level internal and 5 external semi-structured interviews. Our research explores the relationship between various stakeholders and their perceptions of CSR issues. Sixteen themes emerge. We find disparity in CSR perceptions at different levels of organization and in views of consumers. Our recommendations are that the UK fashion retailer needs to – better unde...

  9. Corporate Reputation and Corporate Social Responsibility : CSR for Higher Reputation

    OpenAIRE

    北見, 幸一

    2008-01-01

    There is an increased recognition of importance of corporate reputation and corporate social responsibility. The purpose of this paper is to consider the relationship between corporate reputation and CSR. In this study, the high reputation companies and the low reputation companies were picked up. According to this research, the high reputation companies sent more information about CSR to stake holders, and CSR communication was more positively done than the low reputation companies.

  10. CSR Maturity and Motivation in the Water Sector

    DEFF Research Database (Denmark)

    Lauesen, Linne Marie

    2016-01-01

    Purpose: - This paper aims to examine the literature of CSR motivation and presents research results from a case study of the water sector (water companies from Denmark, the UK, the USA and South Africa) and its motivation for and maturity in its CSR work. Design/methodology/approach - The method......Purpose: - This paper aims to examine the literature of CSR motivation and presents research results from a case study of the water sector (water companies from Denmark, the UK, the USA and South Africa) and its motivation for and maturity in its CSR work. Design......) and Crowther and Reis (2011) CSR maturity typology, the paper suggests an extension of this into a CSR Maturity Framework by adding profit-making, legitimacy and business ethics as clusters of motives for businesses to engage in CSR work. The concrete findings of the water sector suggest it as semi......-mature according to the proposed CSR Maturity Framework, because it has only reached the level of CSR reporting, but neither suggests definitions of sustainability nor shows any particularly good transparency and accountability yet. Research limitations/implications: - The research is limited to water companies...

  11. Global and regional estimates of cancer mortality and incidence by site: I. Application of regional cancer survival model to estimate cancer mortality distribution by site

    Directory of Open Access Journals (Sweden)

    Lopez Alan D

    2002-12-01

    Full Text Available Abstract Background The Global Burden of Disease 2000 (GBD 2000 study starts from an analysis of the overall mortality envelope in order to ensure that the cause-specific estimates add to the total all cause mortality by age and sex. For regions where information on the distribution of cancer deaths is not available, a site-specific survival model was developed to estimate the distribution of cancer deaths by site. Methods An age-period-cohort model of cancer survival was developed based on data from the Surveillance, Epidemiology, and End Results (SEER. The model was further adjusted for the level of economic development in each region. Combined with the available incidence data, cancer death distributions were estimated and the model estimates were validated against vital registration data from regions other than the United States. Results Comparison with cancer mortality distribution from vital registration confirmed the validity of this approach. The model also yielded the cancer mortality distribution which is consistent with the estimates based on regional cancer registries. There was a significant variation in relative interval survival across regions, in particular for cancers of bladder, breast, melanoma of the skin, prostate and haematological malignancies. Moderate variations were observed among cancers of colon, rectum, and uterus. Cancers with very poor prognosis such as liver, lung, and pancreas cancers showed very small variations across the regions. Conclusions The survival model presented here offers a new approach to the calculation of the distribution of deaths for areas where mortality data are either scarce or unavailable.

  12. Impaired class switch recombination (CSR) in Waldenstrom macroglobulinemia (WM) despite apparently normal CSR machinery.

    Science.gov (United States)

    Kriangkum, Jitra; Taylor, Brian J; Strachan, Erin; Mant, Michael J; Reiman, Tony; Belch, Andrew R; Pilarski, Linda M

    2006-04-01

    Analysis of clonotypic isotype class switching (CSR) in Waldenström macroglobulinemia (WM) and IgM monoclonal gammopathy of undetermined significance (MGUS) reveals a normal initial phase of B-cell activation as determined by constitutive and inducible expression of activation-induced cytidine deaminase (AID). Switch mu (Smu) analysis shows that large deletions are not common in WM or IgM MGUS. In CD40L/IL-4-stimulated WM cultures from 2 patients, we observed clonotypic IgG exhibiting intraclonal homogeneity associated with multiple hybrid Smu/Sgamma junctions. This suggests CSR had occurred within WM cells. Nevertheless, the estimated IgG/IgM-cell frequency was relatively low (1/1600 cells). Thus, for the majority of WM B cells, CSR does not occur even when stimulated in vitro, suggesting that the WM cell is constitutively unable to or being prevented from carrying out CSR. In contrast to WM, the majority of IgM MGUS clones exhibit intraclonal heterogeneity of IgH VDJ. Furthermore, most IgM MGUS accumulate more mutations in the upstream Smu region than do WM, making them unlikely WM progenitors. These observations suggest that switch sequence analysis may identify the subset of patients with IgM MGUS who are at risk of progression to WM.

  13. CSR and skepticism: the influence of fit and reputation on skepticism towards CSR communications

    NARCIS (Netherlands)

    Elving, W.J.L.; Bech-Larsen, T.; Frandsen, F.

    2010-01-01

    PURPOSE Consumers tend to be skeptic sometimes towards CSR outlets or communication of companies. In this experiment we tested the influence of fit and reputation on consumer skepticism when confronted with a Cause Related Marketing advertisement. DESIGN In a two (Fit versus no Fit) by three (bad re

  14. Design of Bump Magnet of CSR

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Four bumpers are required for the injection and extraction of CSR. The parameters of the bumpers are shown in table 1. Because of the steep raising and falling time and therefore the inductance of the magnet should be as small as possible, so the material of the magnet cores must be ferrite. And in order to reduce the cost of the bump magnet, the cross-section of the four ferrite cores was designed as the same, as shown in Fig.1.It is very similar to the lamination of the H-type dipole. And Fig.2 is the...

  15. Establishment of CSR Matter-Element Evaluation Model in Perspective of Low Carbon Economy in China

    Directory of Open Access Journals (Sweden)

    Li Furong

    2013-06-01

    Full Text Available With the development of CSR concept, more and more enterprises begin to bring CSR into practice. Especially in the era of low-carbon economy develops quickly, CSR practice is going to mature. In order to make a scientific evaluation on CSR and promote the comprehensive development of CSR, this study develop a new CSR evaluation model under requires of low-carbon economy development. This CSR evaluation model combined G1 weighting method with the Matter-Element Model and finally verified by an example. What we do in this study will provide a good guidance for the development of CSR evaluation and practices.

  16. Post-Transcriptional Regulation by the Csr Global Regulatory System in Escherichia coli

    OpenAIRE

    Suzuki, Kazushi; 鈴木, 一史

    2007-01-01

    In many species of bacteria, the Csr (carbon storage regulator) global regulatory system coordinates the expression of various genes. In Escherichia coli, the central component of this system, CsrA, is a RNA-binding protein. The CsrA is a homodimer and binds to leader segments of target mRNAs, affecting their translation and stability. CsrA activity is regulated by two small non-coding RNAs, CsrB and CsrC. These RNAs contain multiple CsrA-binding sequences and act by sequestering CsrA. In thi...

  17. Consumers’ responses to CSR in a cross-cultural setting

    Directory of Open Access Journals (Sweden)

    Hakan Karaosman

    2015-12-01

    Full Text Available The paper aims to clarify the relationship between corporate social responsibility (CSR and consumer behaviour in an international setting. Consumers’ responses to CSR activities and the impact on the purchase decision are limited discourses. CSR-based studies in the fashion and apparel industry are also scarce. Therefore, this study attempts to enlighten the subject of how consumers from different countries respond to CSR adopted in the fashion and apparel industry. This study is based on an exploratory qualitative research for which focus group interviews, including six group discussions with Spanish and Turkish consumers, have been used. The fundamental dimension for sampling was consumers’ interest and knowledge of CSR-related issues. The data were examined by constant comparison analysis. The paper provides empirical insights that suggest that these consumers, regardless of their country of origin, perceive CSR actions as part of companies’ marketing strategies, while overall consumer awareness to CSR is low. Moreover, the criteria, which determine the purchase decision is to be governed by self-interest. A difference between participants from both countries has been found with regard to their demand for more regulation towards CSR. An identified research need in international marketing discipline, is fulfilled in this study.

  18. Determinants of voluntary CSR disclosure: Empirical evidence from Germany

    NARCIS (Netherlands)

    R. Gamerschlag (Ramin); K. Möller (Klaus); F.H.M. Verbeeten (Frank)

    2011-01-01

    textabstractCurrently, companies spend a great deal of effort on Corporate Social Responsibility (CSR) disclosures. CSR disclosure relates to the provision of information on companies' environmental and social performance. From an economic perspective, companies might disclose this information to av

  19. Individual firm and market dynamics of CSR activities

    NARCIS (Netherlands)

    Wirl, F.; Feichtinger, G.; Kort, P.M.

    2013-01-01

    This paper investigates how firms should plan corporate social responsibility (short CSR). This dynamic analysis starts with a firm's intertemporal optimization problem, and proceeds to analyze interactions with other firms, which are crucial: if CSR is profitable for firm A then it is most likely a

  20. Consumer perceptions of CSR: (how) is China different?

    NARCIS (Netherlands)

    Kolk, A.; van Dolen, W.; Ma, L.

    2015-01-01

    Purpose Most studies on consumers and corporate social responsibility (CSR) have focused on Western contexts. Consequently, good insight is lacking into non-Western markets where consumers may respond differently. China is a case in point, despite the popularity of the CSR concept and high societal

  1. Decoupling among CSR policies, programs, and impacts : An empirical study

    NARCIS (Netherlands)

    Graafland, Johan; Smid, Hugo

    2016-01-01

    There are relatively few empirical studies on the impacts of corporate social responsibility (CSR) policies and programs. This article addresses the research gap by analyzing the incidence of, and the conditions that affect, decoupling (defined as divergence) among CSR policies, implementation of CS

  2. 5 CFR 847.503 - Transfers from the CSR Fund.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Transfers from the CSR Fund. 847.503 Section 847.503 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE... from the CSR Fund. For elections of NAFI retirement system coverage under § 847.441, the amount...

  3. 5 CFR 847.502 - Transfers to the CSR Fund.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Transfers to the CSR Fund. 847.502 Section 847.502 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE... to the CSR Fund. For elections of CSRS or FERS coverage under § 847.411 or FERS coverage and...

  4. CSR: A national and international perspective

    Directory of Open Access Journals (Sweden)

    Towseef Ahmad

    2016-01-01

    Full Text Available Abstract Corporate Social Responsibility has been around for a long time and seems to have a timeless concern for reputation, ethics and values of a Corporation; however, the modern and the scientific era of CSR began with the outstanding contribution of the landmark work entitled, Social Responsibilities of the Businessman by Howard Bowen and subsequent publication of Strategic management: A Stakeholder Approach. This concept has been subjected to a lot of managerial and skilled opinions, discussions and analysis. In spite of the apparently endless discussion and research regarding its contours, it has seen a lots of growth and development in both academic and practitioner circles. Its alternative thematic wheels work to enhance the well being of a community through social and environmental stability vetted with the concept of sustainability, benevolent business practices and responsible stakeholder investment, which assumes a great significance and is assayed within the framework of this article.Keywords: CSR, Stakeholder, Corporations, Principles and Responsibility

  5. Case Study of the Development of CSR in Danfoss

    DEFF Research Database (Denmark)

    Ma, Rufei; Toh, ImnLin; Christensen, Per

    This work‐in‐progress focuses on the CSR practice within the Danfoss Group, a leading global manufacturing company based in Denmark. Its mechanism in CSR policy making and its learning capacity in reaction to changes that may be caused by major events (climate change and the current financial...... crisis) and its global expansion to other countries (globalization), are central in our discussion. Based on the premises of Institutional and Stakeholder theories, a case study investigation was carried out. Information was gathered from the available reports and the accessible online materials, through...... Global Compact. The current financial crisis did not impede the implementation of existing CSR initiatives. Although there is a definite focus in employee relations, Danfoss did not consider formulating a CSR policy simply to attract talented personnel and in retaining staff. The CSR policy was in place...

  6. A Nordic Perspective of Corporate Social Responsibility (CSR

    Directory of Open Access Journals (Sweden)

    Siri Granum Carson

    2011-05-01

    Full Text Available This introduction points to the divergent factors relevant to the topic of CSR, clearly indicating the need for multidisciplinary and cross-disciplinary approaches to this research area. This is reflected in the way CSR has developed at NTNU. For the past 10 years, there has been a focus on CSR in different ways; in course curricula, research projects, and strategic activities across faculties and department and as the focus area within two of the six overall research strategic areas at NTNU: the Globalization research program and the Maritime research program. Environment and energy are core topics in the programs, hereunder long traditions of collaboration with industry in innovative research projects are found. The science and technology profile, but with close connections with the social sciences and humanities, distinguishes CSR research at NTNU. The research focus on CSR attracts students and support possibilities for increased collaboration with industry.

  7. CSR BALANCED SCORECARD SYSTEMS AND BUSINESS PERFORMANCES: SMEs CASE STUDY

    Directory of Open Access Journals (Sweden)

    Edward Sek Khin Wong

    2016-01-01

    Full Text Available This paper aims to examine the performance measurement using the CSR Balanced Scorecard system in SMEs firms in Malaysia. It investigates the relationships of the four perspectives of CSR Balanced Scorecard system toward performance measurement. The purpose of this paper is to in- vestigate whether or not the improvement of the non-financial CSR measures will lead to the im- provement of performance measures. To test these relationships, data were collected using the four perspectives approach introduced by Utting (2007. The finding indicates that the organizational business performance can be greatly increased by putting greater emphasis to CSR measures. The results also reveal that the increases of firms customer’s satisfaction is caused by the increase imple- mentation of CSR measurement. At the end of the article, the implications of this study for SME industries and some suggestions are discussed for future studies.

  8. Analysis of National and EU Policies Supporting CSR and Impact

    DEFF Research Database (Denmark)

    Moon, Jeremy; Slager, Rieneke; Anastasiadis, Stephanos

    The purpose of this report is to provide an overview of the place of governmental policies in encouraging and supporting Corporate Social Responsibility (CSR) and their effectiveness therein. By: Moon, Jeremy - Slager, Rieneke - Brunn, Christoph - Hardi, Peter - Steen Knudsen, Jette - 2012 The very...... thought of a relationship between CSR and government policies would, from some perspectives, seem counter-intuitive or simply wrong. From these perspectives it would appear to be a category error that a concept founded on voluntarism, vs CSR, should be shaped by the antithesis of voluntarism, vs public...... policy. What the report finds however is that in general terms there has been a remarkable growth of public policies for CSR in Europe. This finding is confirmed both by review of the relevant literature but also our own pan-European analysis. No longer is CSR mainly implicit in public policies...

  9. CSR BENEFITS AND COSTS IN A STRATEGIC APPROACH

    Directory of Open Access Journals (Sweden)

    Diana Corina Gligor – Cimpoieru

    2015-09-01

    Full Text Available In recent decades corporate social responsibility (CSR has captured the interest of both practitioners and academics, being a concept extensively analyzed and discussed in terms of its many facets. But maybe due its complexity, still lacking a unified approach and a widely accepted definition, CSR is still often seen as having a peripheral role, auxiliary for a business organization, without even understanding its essence and having overlooked its extraordinary potential to determine multiple bivalent benefits for companies and local communities. Even if CSR benefits are identified, the analysis is often limited to an optimistic view, lacking a realistic approach that recognizes and takes into account also the costs and risks associated. With this paper we aim at identifying the most significant CSR benefits and costs in an attempt to offer a realistic pledging for the importance of CSR implementation in a strategic approach.

  10. Corporate Social Responsibility (CSR) and energy industry; Cororate Social Responsibility (CSR) und Energiewirtschaft

    Energy Technology Data Exchange (ETDEWEB)

    Landhaeusser, Werner (ed.) [Mader GmbH und Co. KG, Leinfelden-Echterdingen (Germany); Hildebrandt, Alexandra

    2016-05-01

    What means Corporate Social Responsibility (CSR) in the energy industry? A rising energy demand with limited natural resources pose utilities, industry and consumers with new challenges. This book follows an interdisciplinary approach and for the first time brings together debates and findings from industry, science, politics, culture and media. Because the energy transition can only succeed if it is comprehensible for the individual and fragmented perspectives and interests are merged. [German] Was bedeutet CSR in der Energiewirtschaft? Ein steigender Energiebedarf bei begrenzten natuerlichen Ressourcen stellt Energieversorger, Industrie und Verbraucher vor immer neue Herausforderungen. Dieses Buch folgt einem interdisziplinaeren Ansatz und fuehrt erstmals Debatten und Erkenntnisse aus Wirtschaft, Wissenschaft, Politik, Kultur und Medien zusammen. Denn die Energiewende kann nur gelingen, wenn sie fuer den Einzelnen fassbar wird und fragmentierte Sichtweisen und Interessenlagen zusammengefuehrt werden.

  11. Relationship between Customer Perception about CSR activities and Purchase Intention: The Role of CSR Communication Channels

    OpenAIRE

    SONG, JINWEN; Fang, Qi; Wang, Jieru

    2015-01-01

    With the incorporation of businesses as major players in a country’s economy and society, Corporate Social Responsibility is becoming a very important aspect of corporate activity. This field is greatly understudied and only limited research has been done on the consequences of conducting CSR activities through different channels of communication. This thesis therefore contributes to a better understanding of the relationship between customer perception and purchase intention in the setting o...

  12. CSR in the Aftermath of the Financial Crisis

    DEFF Research Database (Denmark)

    Lauesen, Linne Marie

    2013-01-01

    Purpose – The purpose of the paper is to examine the literature of CSR before and in the aftermath of the financial crisis in 2008. The aim of the research question is to map out the consequences upon CSR derived from the crisis and to derive new principles of future CSR models to come consistent...... with the consequences of the financial crisis, and to suggest new research as well as policy-­‐making possibilities to highlight the importance and necessary survival of CSR as an instrument for sustainable and financial progress. Design/methodology/approach – The paper uses a literature review of CSR prior...... to and after the financial crisis 2008 with an emphasis on academic papers published in peer-­‐reviewed journals. Findings – The findings of the paper reveal that post-­‐crisis CSR-­‐models do not articulate anything that has not been mentioned before; however they do strengthen former values of CSR, but still...

  13. From CSR to Social Risk Management

    DEFF Research Database (Denmark)

    Taarup Esbensen, Jacob

    2014-01-01

    When it comes to social risks multinational companies (MNC) within Mining are one of the most exposed businesses one can imagine. This paper examines how social risk management is practiced through the case of Teghout copper-molybdenum mine in North- Eastern Armenia, supplemented with evidence from...... other mining MNCs in the country, onsite fieldwork, interviews with key stakeholders, and public available information. This evidence suggest that a standards based social risk management strategy is adopted and that this strategy is based on international Corporate Social Responsibility (CSR) standards...... engagement management systems that is promoted through the standard. The implemented social risk management systems are ineffective because they makes the MNC unable to recognise the value of weak ties and fail to build legitimacy and trust with some of the key stakeholders resulting in the creation of more...

  14. Timing system of HIRFL-CSR

    Institute of Scientific and Technical Information of China (English)

    DONG Jin-Mei; YUAN You-Jin; QIAO Wei-Min; JING Lan; ZHANG Wei

    2009-01-01

    The national science project HIRFL-CSR has recently been officially accepted. As a cyclotron and synchrotron complex, it puts some particularly high demands on the control system. There are hundreds of pieces of equipment that need to be synchronized. An integrated timing control system is built to meet these demands. The output rate and the accuracy of the controller are 16 bit/tzs. The accuracy of the time delay reaches 40 ns. The timing control system is based on a typical event distribution system, which adopts the new event generation and the distribution scheme. The scheme of the timing control system with innovation points, the architecture and the implemented method are presented in the paper.

  15. Defining, Measuring and Supporting Success: Meeting the Challenges of Comprehensive School Reform Research. CSR Connection.

    Science.gov (United States)

    Appelbaum, Deborah; Schwartzbeck, Terri Duggan

    Many educators believe that comprehensive school reform (CSR) holds real promise for improving schools, as many CSR programs are based in research and have documented success. However, in the past year, there has been increased emphasis on CSR programs' evidence of effectiveness and scrutiny of CSR evaluations' degree of rigor. Questions exist…

  16. A feedback-based model for CSR assessment and materiality analysis

    DEFF Research Database (Denmark)

    Calabrese, Armando; Costa, Roberta; Rosati, Francesco

    2015-01-01

    Current CSR literature offers little insight into how to engage customers and other stakeholders about their CSR expectations and perceptions. The aim of this paper is to propose a model for CSR evaluation and planning based on the classification of customer CSR feedback through the comparison of...

  17. Materiality Analysis for CSR Reporting in Spanish SMEs

    Directory of Open Access Journals (Sweden)

    Elena Escrig-Olmedo

    2012-01-01

    Full Text Available Most corporate social responsibility (CSR standards have not been designedto be implemented in small and medium sized enterprises (SMEs. Giventhat 99% of Spanish companies are SMEs, this study aims to propose aselection of basic CSR material issues that, because of their usefulness andsignificance, should be adapted to Spanish SMEs and their stakeholders.This study provides a CSR model for SMEs that includes the most importantsocial, environmental, and corporate governance issues. This model, whichis based on expert knowledge, is useful for integrating sustainability in themanagement of SMEs and enhancing the management of stakeholders.

  18. Consumer inferences of Corporate Social responsibility (CSR) claims on packaged foods

    OpenAIRE

    Kim, Gaeul

    2015-01-01

    With the growing public demands in Corporate Social Responsibility (CSR) of the food industry, CSR claims have begun to appear on food packages, as companies started communicating their CSR initiatives to consumers. Although food packages emerged as an important CSR communication tool, consumers' processing of CSR claims and the effects of these claims on product evaluations still remain unknown. In this regard, the present study carries two important research questions. First, do non-health/...

  19. Innovative CSR: a framework for anchoring corporate social responsibility in the innovation literature

    OpenAIRE

    Preuss, Lutz

    2011-01-01

    Sketching the evolution of corporate social responsibility (CSR) from decoupled corporate philanthropy through strategic CSR to efforts to mainstream CSR throughout the firm, this paper highlights considerable drawbacks of a narrow view of the business case for CSR. Hence it seeks to provide an alternative that is still linked to key business processes but avoids such a tight coupling. The paper argues that this can be achieved through anchoring CSR in the literature on innovation. A definiti...

  20. Analýza CSR aktivit vybrané společnosti

    OpenAIRE

    Kačabová, Petra

    2013-01-01

    The Master thesis deals with a topic of Corporate Social Responsibility. In the theoretical part the CSR concept is explained. The author describes the increasing significance of CSR, its definition, three main pillars, reasons why to implement CSR and its possible crtiticism. Furthermore, it shows indices used for measurement and organizations handling CSR issue. In the practical part, at first, the influnce of CSR on consumers' decision making process and behaviour is demonstrated. The gene...

  1. The Danish CSR Reporting Requirement as Reflexive Law

    DEFF Research Database (Denmark)

    Buhmann, Karin

    2013-01-01

    With effect for financial years beginning January 2009 or later, the Danish Financial Statements Act and related governmental regulations require large Danish companies and institutional investors to submit an annual Corporate Social Responsibility (CSR) report. Through application of reflexive law...

  2. CSR, Employee Job Attitude and Behavior: Saudi Bank Experience

    Directory of Open Access Journals (Sweden)

    Mohammad Tahlil AZIM

    2014-11-01

    Full Text Available The present study explores the relation- ship between the external CSR practices of the organizations and employees’ job satisfaction, employee engagement and organizational cit- izenship behavior in the context of the Saudi banking industry. A positive relationship between CSR and employee job satisfaction, employee engagement and organizational citizenship be- havior related to the organization is observed. However, the organizational citizenship behavior related to individual is found unrelated to CSR. The theoretical foundation of the study is ground- ed in the spirit of social identity theory (Tajfel and Turner, 1979 and social exchange theory (Blau, 1964. The study implies that involvement in ex- ternal CSR may be a determinant for maintaining a motivated and enthusiastic workforce. 

  3. THE RELATIONSHIP BETWEEN MODELS OF QUALITY MANAGEMENT AND CSR

    Directory of Open Access Journals (Sweden)

    CĂTĂLINA SITNIKOV

    2015-03-01

    Full Text Available Lately, the quality management has integrated more and more among its components Corporate Social Responsibility (CSR. With strong roots in the foundation for sustainable development, protection of the environment, issues of social justness and economic growth, CSR raises numerous issues related to obtaining profits, business performance and firms and activities based on the quality of management. From the point of view of the last issues, the models of quality management built on the fundamental principles of quality become the foundation and catalyst for the effective implementation of CSR in organizations. This is the reason why it is necessary to investigate the extent to which quality management models provide frameworks and guidelines for integrating CSR in the management of quality and, moreover, in the management of the organization, with a clear focus on the extent to which the concept can be institutionalized and operated by the organization.

  4. CSR-induced emittance growth in achromats: Linear formalism revisited

    Science.gov (United States)

    Venturini, M.

    2015-09-01

    We review the R-matrix formalism used to describe Coherent Synchrotron Radiation (CSR)-induced projected emittance growth in electron beam transport lines and establish the connection with a description in terms of the dispersion-invariant function.

  5. CSR-induced emittance growth in achromats: Linear formalism revisited

    Energy Technology Data Exchange (ETDEWEB)

    Venturini, M.

    2015-09-11

    We review the R-matrix formalism used to describe Coherent Synchrotron Radiation (CSR)-induced projected emittance growth in electron beam transport lines and establish the connection with a description in terms of the dispersion-invariant function.

  6. Corporate Social Responsibility (CSR in India: A Review

    Directory of Open Access Journals (Sweden)

    Neelmani Jaysawal

    2015-11-01

    Full Text Available Corporate Social Responsibility (CSR is a concept, which states that Private Corporation or public organization has a responsibility to society. It minimizes the cost as well as risks thereby, increasing the brand value and reputation of the company. According to Bowen, “CSR refers to the obligations of businessmen to pursue those policies to make those decisions or to follow those lines of relations which are desirable in terms of the objectives and values of our society.” The CSR activities need to be in tune with effective strategic policies so that the aim of sustainable environmental, social and economic progress may be achieved. Methodology: This paper is based on qualitative research design consisting of review of literature through secondary sources of data collection. The data has been examined through content analysis process from various books, newspaper articles and journals. This paper seeks to explain various initiatives taken in the field of CSR along with some key challenges.

  7. Lönsamhet med CSR hosMAX Hamburgare

    OpenAIRE

    Nisell, Samuel; Kaya, Roni

    2012-01-01

    När företag engagerar sig i CSR-frågor främjar det miljö och samhälle. Denna rapport utreder hur CSR-arbetet också kan gynna företaget ur ett ekonomiskt perspektiv. Rapporten behandlar hamburgerkedjan Max Hamburgares hållbarhetssatsning och besvarar frågorna: • Är Max Hamburgares CSR-arbete ekonomiskt lönsamt för dem själva? • Är någon/några av Max Hamburgares CSR-åtgärder förlust- respektive vinstaffärer? För att besvara frågorna har en omfattande studie kring ämnet och företaget genomförts ...

  8. Should CSR Be Ignored Due to the Economic Crisis?

    Institute of Scientific and Technical Information of China (English)

    Guo Yan

    2009-01-01

    @@ Due to the economic crisis,many companies are struggling for a living.So,should the Corporate Social Responsibilitv(CSR)be put aside before these companies can secure their survival?Of course the answer is no.

  9. Effect of CSR shielding in the compact linear collider

    CERN Document Server

    Esberg, J; Apsimon, R; Schulte, D

    2014-01-01

    The Drive Beam complex of the Compact Linear Collider must use short bunches with a large charge making beam transport susceptible to unwanted effects of Coherent Synchrotron Radiation emitted in the dipole magnets. We present the effects of transporting the beam within a limited aperture which decreases the magnitude of the CSR wake. The effect, known as CSR shielding, eases the design of key components of the facility.

  10. Communicating CSR and Brand Personality through Social Media

    OpenAIRE

    Lopez, Cecilia Maria

    2015-01-01

    In the competitive atmosphere of today's business world, corporate social responsibility (CSR) has become yet another factor organizations use to distinguish themselves and make their values apparent to their audiences. Social media have helped organizations communicate these characteristics with their audiences by enabling timely and cost-effective communication between individuals and organizations. While many studies have explored the role of social media in communicating CSR messages, few...

  11. Social Media: the Wild West of CSR Communications

    OpenAIRE

    Tench, R.; Jones, B

    2015-01-01

    Purpose - The central argument that this paper posits is that traditional media of old presented a clear, ordered world of communication management for organisations to extol their CSR credentials. In contrast to this, new Web 2.0 social media is increasingly being used by activists and hactivists to challenge corporate communication CSR messages and does so by highlighting instances and examples of Corporate Social Irresponsibility (CSI) (Jones, Bowd and Tench, 2009; Tench, Sun and Jones, 20...

  12. Does CSR Create Value for Companies In Malaysia? An Empirical Study of Effect of CSR towards Financial Performance on Shariah and Non Shariah-Compliant Companies in Malaysia

    OpenAIRE

    Ding, Huey Chyi

    2015-01-01

    Over the years, there has been a significant rise in the awareness and practice of Corporate Social Responsibility (CSR) globally. Studies covered various dimensions of CSR have been carried out extensively in developed countries, with results varied that CSR active companies outperformed their peers in term of financial returns, others shown no significant correlations while some concluded that CSR activities do not pay. Similar trend of research gained distinctive attention from the develop...

  13. CSR AND SUSTAINABILITY: AN INVESTIGATION INTO THE PRACTICE OF ONLINE CSR INITIATIVES BY SECONDARY MARKET LISTED COMPANIES IN MALAYSIA

    OpenAIRE

    Nazahah Abd Rahim

    2013-01-01

    Corporate social responsibility (CSR) initiatives are being approached by corporations in so many ways and the most common in forms of campaigns, printed brochures, posters and sponsorships. This is becoming a problem because when corporations use existing resources to carry out their CSR initiatives, sometimes they are being carried away as not to think about whether they are going to have enough resources for future use, so as to become sustainable. But, there is another way of how corporat...

  14. Rectal and colon cancer : Not just a different anatomic site

    NARCIS (Netherlands)

    Tamas, K.; Walenkamp, A. M. E.; de Vries, E. G. E.; van Vugt, M. A. T. M.; Beets-Tan, R. G.; van Etten, B.; de Groot, D. J. A.; Hospers, G. A. P.

    2015-01-01

    Due to differences in anatomy, primary rectal and colon cancer require different staging procedures, different neo-adjuvant treatment and different surgical approaches. For example, neoadjuvant radiotherapy or chemoradiotherapy is administered solely for rectal cancer. Neoadjuvant therapy and total

  15. Rectal and colon cancer: Not just a different anatomic site.

    Science.gov (United States)

    Tamas, K; Walenkamp, A M E; de Vries, E G E; van Vugt, M A T M; Beets-Tan, R G; van Etten, B; de Groot, D J A; Hospers, G A P

    2015-09-01

    Due to differences in anatomy, primary rectal and colon cancer require different staging procedures, different neo-adjuvant treatment and different surgical approaches. For example, neoadjuvant radiotherapy or chemoradiotherapy is administered solely for rectal cancer. Neoadjuvant therapy and total mesorectal excision for rectal cancer might be responsible in part for the differing effect of adjuvant systemic treatment on overall survival, which is more evident in colon cancer than in rectal cancer. Apart from anatomic divergences, rectal and colon cancer also differ in their embryological origin and metastatic patterns. Moreover, they harbor a different composition of drug targets, such as v-raf murine sarcoma viral oncogene homolog B (BRAF), which is preferentially mutated in proximal colon cancers, and the epidermal growth factor receptor (EGFR), which is prevalently amplified or overexpressed in distal colorectal cancers. Despite their differences in metastatic pattern, composition of drug targets and earlier local treatment, metastatic rectal and colon cancer are, however, commonly regarded as one entity and are treated alike. In this review, we focused on rectal cancer and its biological and clinical differences and similarities relative to colon cancer. These aspects are crucial because they influence the current staging and treatment of these cancers, and might influence the design of future trials with targeted drugs.

  16. Implementation of CSR concept in manufacturing SMEs

    Directory of Open Access Journals (Sweden)

    Szczanowicz Justyna

    2014-05-01

    Full Text Available W artykule podejmuje się próbę zaproponowania modelu wdrażania koncepcji społecznej odpowiedzialności biznesu w małych i średnich przedsiębiorstwach produkcyjnych. Na podstawie badań PARP przedstawia się problem jakim jest słaba kondycja SCR w sektorze MSP. Sugeruje się podejście w którym kluczowym aspektem są poziomy społecznej odpowiedzialności biznesu rozumiane jako fundamenty na których przedsiębiorstwo nadbudowuje swoją konkurencyjność. W pracy podkreśla się również inwestycję w praktyki istotne z punktu widzenia kluczowych interesariuszy celem zwiększenie efektywności działań CSR rozumianych jako podniesienie konkurencyjności przedsiębiorstwa.

  17. Corporate Social Responsibility (CSR Effectiveness in the Greek Professional Sport Context

    Directory of Open Access Journals (Sweden)

    John Douvis

    2015-03-01

    Full Text Available The present study examined CSR evaluation issues regarding the effectiveness of CSR activities in Greek professional sport organizations. The initial results illustrated a general absence of CSR effectiveness evaluation. The findings of the study revealed that the majority of respondents have reported that in fact CSR performance is not measured mainly because of a lack of a methodology or a common framework. A major barrier to CSR assessment and evaluation practices is represented by the respondents’ perceptions with respect to the nature of CSR. However, executives and managers mentioned a range of estimations to assess the impacts of their CSR actions, thus CSR effectiveness underlies subjective assessments of positive effect observations. Based on the results and the literature, the present study discusses the implications regarding the issue of CSR measurement and evaluation in Greek professional sport organizations.

  18. Molecular basis for the wide range of affinity found in Csr/Rsm protein-RNA recognition.

    Science.gov (United States)

    Duss, Olivier; Michel, Erich; Diarra dit Konté, Nana; Schubert, Mario; Allain, Frédéric H-T

    2014-04-01

    The carbon storage regulator/regulator of secondary metabolism (Csr/Rsm) type of small non-coding RNAs (sRNAs) is widespread throughout bacteria and acts by sequestering the global translation repressor protein CsrA/RsmE from the ribosome binding site of a subset of mRNAs. Although we have previously described the molecular basis of a high affinity RNA target bound to RsmE, it remains unknown how other lower affinity targets are recognized by the same protein. Here, we have determined the nuclear magnetic resonance solution structures of five separate GGA binding motifs of the sRNA RsmZ of Pseudomonas fluorescens in complex with RsmE. The structures explain how the variation of sequence and structural context of the GGA binding motifs modulate the binding affinity for RsmE by five orders of magnitude (∼10 nM to ∼3 mM, Kd). Furthermore, we see that conformational adaptation of protein side-chains and RNA enable recognition of different RNA sequences by the same protein contributing to binding affinity without conferring specificity. Overall, our findings illustrate how the variability in the Csr/Rsm protein-RNA recognition allows a fine-tuning of the competition between mRNAs and sRNAs for the CsrA/RsmE protein.

  19. Advanced Lung Cancer Screening: An Individualized Molecular Nanotechnology Approach

    Science.gov (United States)

    2016-03-01

    Bethesda, MD, USA2014. Available from: http://seer.cancer.gov/ csr /1975_2011/. 4. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA: a cancer...Bioinformatics 2015. Available from: http:// genome.uscs.edu. 35. Brandes JC, Carraway H, Herman JG. Optimal primer design using the novel primer design...Cancer Statistics Review, 1975-2011. http://seer.cancer.gov/ csr /1975_2011/. 2. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J

  20. The Balance between Internally and Externally Oriented CSR - A case study of Danish SMEs

    DEFF Research Database (Denmark)

    Aagaard, Annabeth; Lemmergaard, Jeanette

    , suppliers and other stakeholders, the internal CSR integration is explained and measured through the level of employee involvement and the content and the effects of internal oriented CSR activities and communication. The diagonal integration is understood as integration with the business strategy.......-sized companies, SMEs. This study explores how four Danish SMEs have integrated CSR, and how the levels of external, internal and diagonal integration affect the qualitative and quantitative results of CSR. Whereas external CSR integration constitutes the external CSR communication and involvement of customers...

  1. CSR Reporting Practices of Polish Energy and Mining Companies

    Directory of Open Access Journals (Sweden)

    Elżbieta Izabela Szczepankiewicz

    2016-01-01

    Full Text Available Corporate Social Responsibility (CSR reporting receives much attention nowadays. Communication with stakeholders is a part of assumed social responsibility, thus the quality of information disclosed in CSR reports has a significant impact on fulfilment of the responsibility. The authors use content analysis of selected CSR reports to describe and assess patterns and structure of information disclosed in them. CSR reports of Polish companies have similar structures at a very high level of analysis, but a more detailed study reveals much diversity in approaches to the report’s content. Even fairly similar companies may devote significantly different amounts of space to the same issue. The number of similar stakeholders varies irrespectively of the company’s size. Considerable diversity of reporting patterns results from the nature of CSR reporting, because it concerns highly entity-specific issues. Thus, such considerable diversity is not surprising. However, many initiatives and efforts are devoted to greater comparability of reporting, so a greater degree of uniformity can be expected. Similar conclusions may be drawn from integrated reports’ analysis, though a small sample reflects the relative novelty of this trend.

  2. CSR Integration into the Financial Economy: A Conceptual Approach

    Directory of Open Access Journals (Sweden)

    Georgiana - Loredana FRECEA

    2016-06-01

    Full Text Available Corporate social responsibility is a complex concept and its design integrates economic, social and environmental issues, pointing out the operational effects on a voluntary basis. It is considered a strategic point in the actual evolution of the economy, due to the financial market dynamism, being identified a critical correlation between financial crises and corporate social responsibility. The main purpose of this paper is to synthesize, through a literature review, the multiple dimensions of CSR, with a special emphasis on the theoretical approach. In order to provide a coherent overview on the banking CSR, it will be proposed a division of the CSR theories according to: (1 the ethical approach, (2 the stakeholders approach, and (3 the corporate governance approach. The major aim of this paper is to fill a gap in the theoretical approach of the CSR for the banking system, due to the necessity to unify the CSR reporting elements in order to find a balance between the bank’s organizational structure and their legitimacy to operate on the financial market.

  3. Actions Objected at Employees in CSR - Report from the Study

    Directory of Open Access Journals (Sweden)

    Szelągowska-Rudzka Katarzyna

    2016-12-01

    Full Text Available The study analyzed the essence of the social responsibility of organizations and indicated the areas of actions to which this concept applies in the organizations. Particular attention has been paid to CSR practices objected at employees as key stakeholders of the organization. The purpose of the study was achieved in the form of analysis of CSR practices addressed to employees of the selected organizations in the Pomeranian Voivodeship. It has been confirmed that the study subjects undertake socially responsible actions addressed to their employees. These actions are compliant with the guidelines of ISO 26000 standard in the area of practice in workplace. However, it has been shown that socially responsible objectives are not commonly present in the strategies of these organizations. Personal strategies and the knowledge of the concept of CSR among employees also occur not frequently enough. The presented study is a pilot study. The reached conclusions apply only to the participating organizations. However, it should be noted that the concept of CSR is not yet widely and successfully implemented in organizations within the Pomeranian Voivodeship. It requires further popularizing and intensifying. Also, the practices of CSR addressed to employees should be further improved.

  4. Using CSR to mitigate information asymmetry in the banking sector

    Directory of Open Access Journals (Sweden)

    Semenescu Andreea

    2015-12-01

    Full Text Available The paper examines the power of corporate social responsibility to reduce information asymmetry and to act as a marketing instrument in the banking sector. Trust is the most important asset of a bank. Therefore, banks are motivated to use the most effective instruments to diminish information asymmetry with their stakeholders. The fact that cash disbursements in CSR actions are not directed towards shareholders makes them more valuable signals to other stakeholders regarding the financial soundness of the bank. The empirical study conducted based on limited dependent variable models supports the effectiveness of the CSR as marketing instrument in banking. It reveals the circumstances associated to a higher probability of an active CSR policy conducted by a banking institution. The results support the hypothesis that in the banking sector CSR is perceived as an instrument which helps stakeholders reduce information asymmetry. As marketing instrument, CSR contributes to increasing the tangibility of the banking products, decreasing their perceived variability and thus making them more attractive for the clients and allowing for differentiation between competitors.

  5. The Helicobacter pylori J99 jhp0106 Gene, under the Control of the CsrA/RpoN Regulatory System, Modulates Flagella Formation and Motility

    Science.gov (United States)

    Kao, Cheng-Yen; Chen, Jenn-Wei; Wang, Shuying; Sheu, Bor-Shyang; Wu, Jiunn-Jong

    2017-01-01

    CsrA has been shown to positively control the expression of flagella-related genes, including flaA and flaB, through regulating expression of an alternative sigma factor RpoN in Helicobacter pylori J99. Here, we aimed to characterize the CsrA regulatory system by comparative transcriptomic analysis carried out with RNA-seq on strain J99 and a csrA mutant. Fifty-three genes in the csrA mutant were found to be differentially expressed compared with the wild-type. Among CsrA-regulated genes, jhp0106, with unclear function, was found located downstream of flaB in the J99 genome. We hypothesized that flaB-jhp0106 is in an operon under the control of RpoN binding to the flaB promoter. The RT-qPCR results showed the expression of jhp0106 was decreased 76 and 92% in the csrA and rpoN mutants, respectively, compared to the wild-type. Moreover, mutations of the RpoN binding site in the flaB promoter region resulted in decreased expression of flaB and jhp0106 and deficient motility. Three-dimensional structure modeling results suggested that Jhp0106 was a glycosyltransferase. The role of jhp0106 in H. pylori was further investigated by constructing the jhp0106 mutant and revertant strains. A soft-agar motility assay and transmission electron microscope were used to determine the motility and flagellar structure of examined strains, and the results showed the loss of motility and flagellar structure in jhp0106 mutant J99. In conclusion, we found jhp0106, under the control of the CsrA/RpoN regulatory system, plays a critical role in H. pylori flagella formation.

  6. Effects of Core-Shell Rubber (CSR) Nanoparticles on the Cryogenic Fracture Toughness of CSR Modified Epoxy

    Science.gov (United States)

    Wang, Jun; Magee, Daniel; Schneider, Judy; Cannon, Seth

    2009-01-01

    This study investigated the effects of core-shell rubber (CSR) nanoparticles on the mechanical properties and fracture toughness of an epoxy resin at ambient and liquid nitrogen (LN2) temperatures. Varying amounts of Kane Ace(Registered TradeMark) MX130 and Kane Ace(Registered TradeMark) MX960 toughening agent were added to a commercially available EPON 862/Epikure W epoxy resin. Elastic modulus was calculated using quasi-static tensile data. Fracture toughness was evaluated by the resulting breaking energy measured in Charpy impact tests conducted on an instrumented drop tower. The size and distribution of the CSR nanoparticles were characterized using Transmission Electron Microscopy (TEM) and Small Angle X-ray Scattering (SAXS). Scanning Electron Microscopy (SEM) was used to study the fracture surface morphology. The addition of the CSR nanoparticles increased the breaking energy with negligible change in elastic modulus and ultimate tensile stress (UTS). At ambient temperature the breaking energy increased with increasing additions of the CSR nanoparticles up to 13.8wt%, while at LN2 temperatures, it reached a plateau at much lower CSR concentration.

  7. CSR and the Mediated Emergence of Strategic Ambiguity

    DEFF Research Database (Denmark)

    Guthey, Eric; Morsing, Mette

    2014-01-01

    We develop a framework for understanding how lack of clarity in business press coverage of corporate social responsibility functions as a mediated and emergent form of strategic ambiguity. Many stakeholders expect CSR to exhibit clarity, consistency, and discursive closure. But stakeholders also...... expect CSR to conform to varying degrees of both formal and substantive rationality. These diverse expectations conflict with each other and change over time. A content analysis of press coverage in Denmark suggests that the business media reflect and amplify the ambiguity generated by these shifting......, not from the direct intentions of individual stakeholders. Our framework suggests that CSR is best understood not as a clear or consistent agenda, but rather as a forum for sensemaking, diversity of opinion, and debate over the conflicting social norms and expectations attached to corporate activity....

  8. DOES CSR ENHANCE MARKET PERFORMANCE FOR AUTOMOTIVE COMPANIES?

    Directory of Open Access Journals (Sweden)

    Anca BUTNARIU

    2016-12-01

    Full Text Available This paper aims at analyzing the role of strategic CSR in creating stable long term performance in the automotive industry. The first part of the paper reviews the success factors for the European auto industry and analyses the influence strategic CSR has on these factors. In order to illustrate the relation between strategic CSR activities and the economic performance, the paper presents the strategic evolution of one of the most ancient motor companies on the international scene, namely Peugeot and evaluates the innovative ideas brought into the market, as well as its future prospects. The PSA Group holds a position of European leader in terms of CO2 emissions, with an average of 110.3 grams of CO2/km in 2014. The PSA Peugeot Citroen Group’s strategy is being increasingly oriented towards environmental protection and energy saving.

  9. The integration of corporate social responsibility (CSR) initiatives into business activities

    DEFF Research Database (Denmark)

    Knudsen, Jette Steen

    2013-01-01

    While proponents of corporate social responsibility (CSR) have suggested that CSR initiatives should be integrated into mainstream business activities as 'strategic CSR' or 'shared value', research is lacking that explores how CSR programmes are integrated in companies. This paper compares CSR...... initiatives with human resource management (HRM) activities, which have a longer tradition of being integrated into company strategy. The focus is on gender diversity and CSR in a US multinational corporation (MNC). The MNC sees gender diversity as an integral part of business activities. In contrast, the MNC...... lacks a clear justification for the much broader CSR agenda, CSR activities seem not to reflect an overall set of values or purpose, integration into business activities is unclear, and targets are lacking....

  10. Brother of Regulator of Imprinted Sites (BORIS) suppresses apoptosis in colorectal cancer

    Science.gov (United States)

    Zhang, Yanmei; Fang, Mengdie; Song, Yongfei; Ren, Juan; Fang, Jianfei; Wang, Xiaoju

    2017-01-01

    Identifying oncogenes that promote cancer cell proliferation or survival is critical for treatment of colorectal cancer. The Brother of Regulator of Imprinted Sites (BORIS) is frequently expressed in most types of cancer, but rarely in normal tissues. Aberrantly expressed BORIS relates to colorectal cancer, but its function in colorectal cancer cells remains unclear. In addition, previous studies indicated the significance of cytoplasm-localized BORIS in cancer cells. However, none of them investigated its function. Herein, we investigated the functions of BORIS in cancer cell proliferation and apoptosis and the role of cytoplasm-localized BORIS in colorectal cancer. BORIS expression correlated with colorectal cancer proliferation. BORIS overexpression promoted colorectal cancer cell growth, whereas BORIS knockdown suppressed cell proliferation. Sensitivity of colorectal cancer cells to 5-fluorouracil (5-FU) was inversely correlated with BORIS expression. These data suggest that BORIS functions as an oncogene in colorectal cancer. BORIS silencing induced reactive oxygen species (ROS) production and apoptosis, whereas BORIS supplementation inhibited apoptosis induced by BORIS short interfering RNA (siRNA), hydrogen peroxide (H2O2) or 5-FU. Introduction of BORIS-ZFdel showed that cytoplasmic localization of BORIS inhibited apoptosis but not ROS production. Our study highlights the anti-apoptotic function of BORIS in colorectal cancer. PMID:28098226

  11. The Collectivity in Csr 129Xe+129Xe Collisions

    Science.gov (United States)

    Xie, Fei; Wu, Kejun; Liu, Feng

    The Heavy Ion Research Facility in Lanzhou (HIRFL) - Cooler Storage Ring (CSR), which can gather few hundreds MeV/nucleon for heavy ion beam energy in the external-target experiments, could make a significant contribution in studying the property of dense matter. By using a Relativistic Transport Model(ART1.0), we study the collectivity of identified hadrons in 129Xe+129Xe collisions in CSR energy regions. Our investigation indicates that the anisotropic flow reaches its extremum around 500 MeV/nucleon of beam energy. The system size and EOS dependence on anisotropic flow show that directed flow is very sensitive to the equation of state.

  12. Impact on the magnetic compressor due to CSR

    Institute of Scientific and Technical Information of China (English)

    LIU Chu-Yu; WANG Fang; WANG Er-Dong; QUAN Sheng-Wen; HAO Jian-Kui; LU Xiang-Yang; ZHANG Bao-Cheng; ZHAO Kui

    2008-01-01

    When an electron bunch is compressed in a chicane compressor,the CSR (coherent synchrotron radiation) will induce energy redistribution along the bunch.Such energy redistribution will affect the longitudinal emittance as a direct consequence.It will also excite betatron oscillation due to the chromatic transfer functions,and hence a transverse emittance change.So,it is indispensable for us to find a way to alleviate the CSR-cansed emittance dilution and the bad result of chicane compressor in PKU-FEL.

  13. Ye olde CSR: the historic roots of corporate social responsibility in Norway

    OpenAIRE

    Ihlen, Øyvind; Høivik, Heidi von Weltzien

    2015-01-01

    This essay traces the roots of corporate social responsibility (CSR) in Norway. It is argued that a basic tenet of CSR, an orientation toward the concerns of stakeholders, has a long history in Norwegian business, predating the modern CSR movement. The essay underscores certain qualities of the Norwegian business system and the Norwegian political culture in order to explain how this stakeholder orientation grew and how CSR is perceived and practiced today. Corporatism and dialog are traits w...

  14. PENGARUH PENERAPAN CORPORATE SOCIAL RESPONSIBILITY ( CSR ) TERHADAP CITRA PERUSAHAAN PADA PT. HADJI KALLA CABANG SULTAN ALAUDDIN

    OpenAIRE

    MAJID, PARAMITA

    2012-01-01

    - This research aims to determine the influence either together or partially between CSR (Corporate Social Responsibility) to corporate image in PT. Hadji Kalla Cabang Sultan Alaudin, Makassar area, that being measured from CSR variables which is Profit, People, and Planet. Expectedly the information obtained from this research can be used by companies to increase CSR activities and quality of CSR programs so that more can enh...

  15. HVORDAN INTEGRERES CSR I SMÅ OG MELLEMSTORE VIRKSOMHEDER OG HVAD PÅVIRKER INTEGRATIONSFORMEN?

    DEFF Research Database (Denmark)

    Aagaard, Annabeth

    2016-01-01

    CSR integration i små og mellemstore virksomheder (SMV’er) mangelfuld, og flere studier påpeger at der er væsentlig forskel på CSR og CSR integration når man sammenligner store virksomheder og SMV’er. Denne artikel ønsker at undersøge, hvordan små og mellemstore virksomheder integrerer CSR og hvad der...

  16. Analýza CSR ve vybrané firmě

    OpenAIRE

    Hořejší, Renata

    2012-01-01

    This thesis deals with Corporate Social Responsibility. In the theoretical part the basic concepts of Corporate Social Responsibility are determined and introduced initiatives dealing with CSR at national, European and global level. The definition of methods for measuring CSR, communication, implementation and benefits of CSR for the company are also included in this part. The practical part is focused on the company Skupina ČEZ. There is company presentation, particular CSR activities and re...

  17. Polymorphisms in miRNA binding site: new insight into small cell lung cancer susceptibility

    Institute of Scientific and Technical Information of China (English)

    Hong-yu LIU; Jun CHEN

    2011-01-01

    Lung cancer is a leading cause in cancer-related deaths with less than 15% five-year survival worldwide.Small cell lung cancer (SCLC),which accounts for about 15%-18% of lung cancer,carries the worst prognosis within the lung cancer patients.SCLC differs from other lung cancers,so called non-small cell lung cancers (NSCLCs),in the specifically clinical and biologic characteristics.It exhibits aggressive behavior,with rapid growth,early spread to distant sites.Although exquisite sensitive to chemotherapy and radiation,SCLC recurs rapidly with only 5% of patients surviving five years and frequent association with distinct paraneoplastic syndromes[1].

  18. PERSEPSI MASYARAKAT TERHADAP PARTISIPASI MEREKA DALAM PROGRAM CSR PT HOLCIM INDONESIA Tbk – CILACAP PLANT

    OpenAIRE

    Rio Irawan, Stephanus

    2014-01-01

    Corporate Social Responsibility (CSR) telah menjadifokus perhatian dari banyak perusahaan. Survei McKinleySurvei Globalmenunjukkan bahwa76% darieksekutifpercaya bahwatanggung jawab sosial perusahaanmemberikan kontribusipositif terhadapnilai pemegang sahamjangka panjang, dan 55% eksekutif setuju bahwa CSRmembantuperusahaan merekamembangunreputasi yang kuat. Dengan kata lain, CSR berkaitan dengan kebutuhan perusahaan untuk menaikkan citra positifnya, dan dengan melakukan CSR p...

  19. The bad, the ugly and the good: new challenges for CSR communication

    NARCIS (Netherlands)

    Elving, W.J.L.; Golob, U.; Podnar, K.; Ellerup-Nielsen, A.; Thomson, C.

    2015-01-01

    Purpose - This editorial is an introduction to the special issue on CSR Communication attached to the second CSR Communication Conference held in Aarhus (Denmark) in September 2013. The purpose of this paper is to critically evaluate the role of CSR communication and the development of theory and pr

  20. Framing CSR fit: How corporate social responsibility activities are covered by news media

    NARCIS (Netherlands)

    Lunenberg, Katharina; Gosselt, Jordy F.; Jong, de Menno D.T.

    2016-01-01

    This research provides a basis for understanding how the contents of media coverage about CSR activities relates to the fit between these CSR activities and the organizations’ core activities. In two steps, 513 news articles about organizations’ CSR activities were analyzed. First, an expert review

  1. How Does It Fit? Exploring the Congruence Between Organizations and Their Corporate Social Responsibility (CSR) Activities

    NARCIS (Netherlands)

    Jong, de Menno D.T.; Meer, van der Mark

    2015-01-01

    Several studies have focused on the effects of corporate social responsibility (CSR) fit on external stakeholders’ evaluations of CSR activities, attitudes towards companies or brands, and behaviors. The results so far have been contradictory. A possible reason may be that the concept of CSR fit is

  2. 17 CFR 274.128 - Form N-CSR, certified shareholder report.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Form N-CSR, certified... Form N-CSR, certified shareholder report. This form shall be used by registered management investment... of this chapter. Editorial Note: For Federal Register citations affecting Form N-CSR, see the List...

  3. The Csr system regulates genome-wide mRNA stability and transcription and thus gene expression in Escherichia coli.

    Science.gov (United States)

    Esquerré, Thomas; Bouvier, Marie; Turlan, Catherine; Carpousis, Agamemnon J; Girbal, Laurence; Cocaign-Bousquet, Muriel

    2016-04-26

    Bacterial adaptation requires large-scale regulation of gene expression. We have performed a genome-wide analysis of the Csr system, which regulates many important cellular functions. The Csr system is involved in post-transcriptional regulation, but a role in transcriptional regulation has also been suggested. Two proteins, an RNA-binding protein CsrA and an atypical signaling protein CsrD, participate in the Csr system. Genome-wide transcript stabilities and levels were compared in wildtype E. coli (MG1655) and isogenic mutant strains deficient in CsrA or CsrD activity demonstrating for the first time that CsrA and CsrD are global negative and positive regulators of transcription, respectively. The role of CsrA in transcription regulation may be indirect due to the 4.6-fold increase in csrD mRNA concentration in the CsrA deficient strain. Transcriptional action of CsrA and CsrD on a few genes was validated by transcriptional fusions. In addition to an effect on transcription, CsrA stabilizes thousands of mRNAs. This is the first demonstration that CsrA is a global positive regulator of mRNA stability. For one hundred genes, we predict that direct control of mRNA stability by CsrA might contribute to metabolic adaptation by regulating expression of genes involved in carbon metabolism and transport independently of transcriptional regulation.

  4. Epidemiology of upper gastrointestinal cancers in Iran: A Sub site analysis of 76t cases

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    AIM: To define the sub site distribution of upper gastrointestinal cancers in three provinces of Tran. METHODS: The study was carried out in three provinces in Tran: Ardabil, Golestan, and Tehran. Tn Arbabil and Golestan, the data was collected from the sole referral center for gastrointestinal cancers and the local cancer registry. For Tehran province, data from two major private hospitals were used. All gastric and esophageal cancer patients diagnosed during the period from September 2000 and April 2002 were included in the study. RESULTS: A total of 761 patients with upper gastrointestinal cancers were identified, 314 from Ardabil, 261 from Golestan, and 186 from Tehran. In Tehran, the relative rate of cancer increased from the upper esophagus to the distal stomach. In Golestan, the reverse pattern was observed. In Ardabil, the mid portion (distal esophagus and proximal stomach) was involved most frequently. CONCLUSION: There were considerable variations in the sub site of upper gastrointestinal cancers in the three provinces studied. We cannot provide any explanation for this variation. Further research aimed at explaining the discrepancies in sub site distribution of upper gastrointestinal cancers may help identify important risk factors.

  5. Opening the CSR Discourse for Critical Stakeholders in Social Media

    DEFF Research Database (Denmark)

    Etter, Michael

    This study examines how a contested fast food chain in the middle of on-going image transformation efforts opens the distorted discourse about CSR with a social media campaign and enables the interference of official corporate communication and stakeholder critique. The study examines how...

  6. Closing the Achievement Gap: Urban Schools. CSR Connection.

    Science.gov (United States)

    Porter, Kathleen; Soper, Stephanie

    This report reviews efforts to reform urban schools, focusing on initiatives in Tennessee and California as examples from which distric leaders may draw useful lessons. The report suggests that comprehensive school reform (CSR) offers promise to struggling urban schools by focusing on transforming the academic climate, school culture, and…

  7. Multinationals, CSR and partnerships in Central African conflict countries

    NARCIS (Netherlands)

    Kolk, A.; Lenfant, F.

    2013-01-01

    Attention has increased for the potential role of multinational enterprises (MNEs) in helping address conflict issues and/or furthering peace and reconciliation as part of their corporate social responsibility (CSR) policies. However, while existing literature emphasises the importance for MNEs to c

  8. MNC reporting on CSR and conflict in Central Africa

    NARCIS (Netherlands)

    Kolk, A.; Lenfant, F.

    2010-01-01

    In recent years, corporate social responsibility (CSR) of Multinational Corporations (MNCs) in developing countries has received more attention. However, in this literature Africa is much less well represented than other regions, and existing studies about Africa have mainly focused on South Africa

  9. Non-financial reporting, CSR frameworks and groups of undertakings

    DEFF Research Database (Denmark)

    Szabó, Dániel Gergely; Sørensen, Karsten Engsig

    2017-01-01

    The recently adopted Directive on non-financial reporting (Directive 2014/95/EU) and several CSR frameworks are based on the assumption that groups of undertakings adopt, report and implement one group policy. This is a very important but also rather unique approach to groups. This article first...

  10. Are CSR disclosures relevant for investors? Empirical evidence from Germany

    NARCIS (Netherlands)

    Verbeeten, F.H.M.; Gamerschlag, R.; Möller, K.

    2016-01-01

    Purpose – The purpose of this paper is to examine whether narrative corporate social responsibility (CSR) disclosures (the provision of textual information on companies’ environmental and social performance to external stakeholders) are associated with firm value in Germany. Design/methodology/appro

  11. SOCIAL PERFORMANCE ENHANCES FINANCIAL PERFORMANCE. BENEFITS FROM CSR

    Directory of Open Access Journals (Sweden)

    gazzola patrizia

    2012-07-01

    Full Text Available The research aims to show how Corporate Social Responsibility (CSR should not be considered a cost to bear as an economic social actor but an investment that will contribute to the competitiveness and growth of the firm. In the first part we consider capitalistic firm as systems for the creation of economic and financial value for their shareholders. We measure their performance by a system of monetary values. In the second part we do not limit our view to simply the shareholders, but we consider, instead a vast group of stakeholders because it is important not only to make profits, but also how companies make them . In these years characterized by the financial crisis, where many big companies went bankrupt, more and more companies are speaking about ethics and CSR. For a firm, acting socially responsible, means for example having fair compensations, promoting transparency and the respect of employees, neutralizing conflicts of interest, as well as taking care of the environment. CSR is today a topic for discussion not only for business people but also for politicians, media, researchers, NGOs and consumers. Growing awareness of CSR is evident in the growth of voluntary codes of corporate conduct, in the growth of companies that are using self-reporting on social and environmental practices, and in increasingly social and ethical investment funds. The public and governments of the world have been steadily increasing pressure on corporations to increase their CSR. Recently the European Commission has put forward a new, simpler definition of corporate social responsibility as “the responsibility of enterprises for their impacts on society” (European Commission 25/10/2011. Companies have realized that to increase their market share or keep their market share, they must adopt CSR, but the synergy between social performance and financial performance is not automatic; rather it is the result of efforts that combine managerial

  12. PELAKSANAAN PENGELOLAAN DAN PEMANTAUAN LINGKUNGAN BERDASARKAN DOKUMEN RKL & RPL SERTA CORPORATE SOCIAL RESPONSIBILITY (CSR DI PT. TAMAN NUSA GIANYAR

    Directory of Open Access Journals (Sweden)

    I Komang Tri Sumandiarta

    2016-12-01

    Full Text Available Taman Budaya Nusantara is one of the tourism site that is located in Gianyar which being managed by PT. Taman Nusa. The negative impact from tourism site is an enhancement of environmental destruction. This research aims to analyze the adherence implementation of the Environmental Management Plan document (RKL, Environmental Monitoring Plan document (RPL and the implementation of CSR Program. The methods that used were in the research are case approachment (The Case Approach, Legislation approachment (The Statue Approach, and Conceptual approachment (Analytical and ConcePT. ual Approach. The result of the research shows that PT. Taman Nusa did not comply to the terms of legislation according to the implementation of EIA document five aspects, is Permitting, Water Pollution Control, Air Pollution Control, Hazardoces Waste Management and Solid Waste Management. PT. Taman Nusa has fulfilled obligations in carrying out its social responsibility, economic and environment by actualizing the CSR program according to the Article 74 of Constitution No 40 of 2007 about Limited Liability Company (PT. The implementation of CSR program covers 14% of the total Sidan village. PT. Taman Nusa Should perform a reparation in managing and controlling the environment according to the rules of constitution which have been suggested by local government through the BLH Gianyar to do some evaluation and reviewing the AMDAL Document of PT. Taman Nusa and conductlinkagemappingof stakeholder sandterritoriesforthe implementation of theoverallCSRprogramin the VillageSidan.

  13. The Integration of Corporate Social Responsibility (CSR) Initiatives into Business Activities

    DEFF Research Database (Denmark)

    Knudsen, Jette Steen

    While proponents of Corporate Social Responsibility (CSR) have suggested that CSR initiatives should be integrated into mainstream business activities as ‘strategic CSR’ or ‘shared value’, research is lacking that explores how CSR initiatives are integrated in companies. This article compares CSR...... initiatives to human resource management (HRM) initiatives, which have a longer tradition of being integrated into company strategy. The focus is on gender diversity and CSR initiatives in a US multinational corporation (MNC). The MNC sees gender diversity as an integral part of business activities...

  14. The global regulatory system Csr senses glucose through the phosphoenolpyruvate: carbohydrate phosphotransferase system.

    Science.gov (United States)

    Pérez-Morales, Deyanira; Bustamante, Víctor H

    2016-02-01

    A novel connection between two regulatory systems controlling crucial biological processes in bacteria, the carbon storage regulator (Csr) system and the glucose-specific phosphotransferase system (PTS), is reported by Leng et al. in this issue. This involves the interaction of unphosphorylated EIIA(Glc), a component of the glucose-specific PTS, with the CsrD protein, which accelerates the decay of the CsrB and CsrC small RNAs via RNase E in Escherichia coli. As unphosphorylated EIIA(G) (lc) is generated in the presence of glucose, the PTS thus acts as a sensor of glucose for the Csr system. Interestingly, another pathway can operate for communication between the Csr system and the glucose-specific PTS. The absence of glucose generates phosphorylated EIIA(Glc) , which activates the enzyme adenylate cyclase to produce cyclic adenosine monophosphate (cAMP) that, in turn, binds to the regulator cAMP receptor protein (CRP). Leng et al. show that the complex cAMP-CRP modestly reduces CsrB decay independently of CsrD. On the other hand, a previous study indicates that the complex cAMP-CRP positively regulates the transcription of CsrB and CsrC in Salmonella enterica. Therefore, EIIA(G) (lc) could work as a molecular switch that regulates the activity of the Csr system, in response to its phosphorylation state determined by the presence or absence of glucose, in order to control gene expression.

  15. Bioinformatics Study of Cancer-Related Mutations within p53 Phosphorylation Site Motifs

    Directory of Open Access Journals (Sweden)

    Xiaona Ji

    2014-07-01

    Full Text Available p53 protein has about thirty phosphorylation sites located at the N- and C-termini and in the core domain. The phosphorylation sites are relatively less mutated than other residues in p53. To understand why and how p53 phosphorylation sites are rarely mutated in human cancer, using a bioinformatics approaches, we examined the phosphorylation site and its nearby flanking residues, focusing on the consensus phosphorylation motif pattern, amino-acid correlations within the phosphorylation motifs, the propensity of structural disorder of the phosphorylation motifs, and cancer mutations observed within the phosphorylation motifs. Many p53 phosphorylation sites are targets for several kinases. The phosphorylation sites match 17 consensus sequence motifs out of the 29 classified. In addition to proline, which is common in kinase specificity-determining sites, we found high propensity of acidic residues to be adjacent to phosphorylation sites. Analysis of human cancer mutations in the phosphorylation motifs revealed that motifs with adjacent acidic residues generally have fewer mutations, in contrast to phosphorylation sites near proline residues. p53 phosphorylation motifs are mostly disordered. However, human cancer mutations within phosphorylation motifs tend to decrease the disorder propensity. Our results suggest that combination of acidic residues Asp and Glu with phosphorylation sites provide charge redundancy which may safe guard against loss-of-function mutations, and that the natively disordered nature of p53 phosphorylation motifs may help reduce mutational damage. Our results further suggest that engineering acidic amino acids adjacent to potential phosphorylation sites could be a p53 gene therapy strategy.

  16. Prostate Cancer Clinical Trials Group: The University of Michigan Site

    Science.gov (United States)

    2012-04-01

    cerebrovascular accident, myocardial infarction, unstable angina, or coronary artery stenting within 6 months of enrollment, or a history of venous thrombosis ...of the promoter and the transcription factor of the ETS fusion is more effective than targeting a single aspect of the fusion. The TMPRSS2-ETS gene...Phase I and biomarker study of Everolimus combined with hormonal and radiation therapy for high risk prostate cancer introduced to the PCCTC by Dr

  17. Cancer trends in Kashmir; common types, site incidence and demographic profiles: National Cancer Registry 2000-2012

    Directory of Open Access Journals (Sweden)

    M A Wani

    2014-01-01

    Full Text Available Background: An assessment of cancer incidence in population is required for prevention, early diagnosis, treatment and resource allocation. This will also guide in the formation of facilities for diagnosis, treatment, rehabilitation and follow-up for these patients. The demographic trend of cancer will help to identify common types and etiological factors. Efforts at clinical, research and administrative levels are needed to overcome this problem. Settings and Design: Present retro prospective study was conducted in regional cancer center of a tertiary care hospital. Materials and Methods: After permission from ethics committee, a retro prospective study of 1 year duration was undertaken to study the profile of cancer patients and to compare it with other cancer registries in India. Statistical Analysis: Pearson′s Chi-square test and simple linear regression were used. Statistical Package for the Social Sciences version-16 (University of Bristol information services (www.bristol.ac.uk/is/learning/resources was used. RESULTS: The overall incidence of cancer in Kashmir is on the increase and common sites of cancer are esophagus and gastroesophageal (GE junction, lung, stomach, colorectal, lymphomas, skin, laryngopharynx, acute leukemias, prostate and brain in males.In females common sites are breast, esophagus and GE junction, ovary, colorectal, stomach, lung, gallbladder, lymphomas, acute leukemias and brain. Conclusion: Cancers of esophagus, stomach and lungs have a high incidence both in men and women in Kashmir. Future studies on sources and types of environmental pollution and exposures in relation to these cancers may improve our understanding of risk factors held responsible for causation of these malignancies in this region. This will help in the allocation of available resources for prevention and treatment strategies.

  18. Relationship of oral cancer with age, sex, site distribution and habits.

    Science.gov (United States)

    Patel, Mandakini Mansukh; Pandya, Amrish N

    2004-04-01

    Many studies are carried out regarding age incidence, tobacco smoking and sites of oral cancer, but in Gujarat tobacco chewing in form of Gutkha is more common than smoking and start during preteen years. Tobacco chewing causing chronic inflammation, submucous fibrosis and oral cancer. This study was conducted on 504 patients to find out if there is increasing incidence of oral cancer in lower age group and its relation with sex as well which site was commonly affected. There was statistically significant increase in oral cancer in lower age group, and anatomically anterior part of oral cavity showed involvement in 61.32% of cases. Though males were affected more but female cases were 25%. So tobacco chewing has got detrimental effect on oral cavity.

  19. Associations of cancer site and type with occupation and industry from the Third National Cancer Survey Interview.

    Science.gov (United States)

    Williams, R R; Stegens, N L; Goldsmith, J R

    1977-10-01

    From the Third National Cancer Survey (TNCS) Interview Study of 7,518 incident cases, lifetime histories of occupations and industries were studied for associations with specific cancer sites and types while controlling for age, sex, race, education, use of cigarettes or alcohol, and geographic location. Lung cancer patients were found more often than expected among several categories including trucking, air transportation, wholesaling, painting, building construction, building maintenance, and manufacturing (furniture, transportation equipment, and food products). Controlling for cigarette smoking did not change these associations. Leukemia and multiple myeloma were associated with sales personnel of both sexes, whereas lymphomas and Hodgkin's disease were excessive among women working in the medical industry. Other associations included rectal cancer with several retail industries; prostate cancer with ministers, farmers, plumbers, and coal miners; malignant melanoma with school teachers; and invasive cervical cancer with women working in hotels and restaurants. Breast cancer patients were more common among women who were teachers or other professionals and who worked in business and finance (even after controlling for education). Many other findings are presented in detailed tables. Results are reported mainly as a research resource for use by other investigators doing work in this field. Suggestions are given for future studies.

  20. Cancer and African Americans

    Science.gov (United States)

    ... 4 Pancreas 12.2 9.5 1.3 Stomach 4.2 1.8 2.3 Source: NCI 2016. Seer Cancer Statistics Review, 1975-2013. Tables 1.21 http://seer.cancer.gov/csr/1975_2013/sections.html Screening Breast Cancer Percent of women age 40 and ...

  1. CSR behavior and aging model for the Viton© Fluorelastomer O-rings in the 9975 shipping package

    Energy Technology Data Exchange (ETDEWEB)

    Mcwilliams, A. J. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Daugherty, W. L. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Skidmore, T. E. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-12-01

    The 9975 Type B shipping package is used within the DOE complex for shipping special nuclear materials. This package is re-certified annually in accordance with Safety Analysis Report for Packaging (SARP) requirements. The package is also used at the Savannah River Site as part of the long-term storage configuration of special nuclear materials. As such, the packages do not undergo annual recertification during storage, with uncertainty as to how long some of the package components will meet their functional requirements in the storage environment. The packages are currently approved for up to 15 years storage, and work continues to provide a technical basis to extend that period. This report describes efforts by the Savannah River National Laboratory (SRNL) to extend the service life estimate of Viton® GLT and GLT-S fluoroelastomer O-rings used in the 9975 shipping package. O-rings of both GLT and GLT-S compositions are undergoing accelerated aging at elevated temperature, and are periodically tested for compression stress relaxation (CSR) behavior. The CSR behavior of O-rings was evaluated at temperatures from 175 to 400 °F. These collective data were used to develop predictive models for extrapolation of CSR behavior to relevant service temperatures (< 156 °F). The predictive model developed from the CSR data conservatively indicates a service life of approximately 37 years for Viton GLT O-rings at the maximum effective service temperature of 156 °F. The estimated service life for Viton GLT-S O-rings is significantly longer.

  2. Post site metastasis of breast cancer after video-assisted thoracic surgery for pulmonary metastasis of breast cancer: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Park, Mee Hyun; Hwang, Ji Young; Hyun, Su Jeong; Lee, Yul; Woo, Ji Young; Yang, Ik; Hong, Hye Sook; Kim, Han Myun [Dept. of Radiology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul (Korea, Republic of)

    2016-05-15

    We reported a case of port site metastasis in a 57-year-old patient who underwent video-assisted thoracic surgery (VATS) resection of pulmonary metastasis from breast cancer. Port site metastasis after VATS is very rare in patients with breast cancer. However, when suspicious lesions are detected near the port site in patients who have undergone VATS for pulmonary metastasis, port site metastasis should be considered in the differential diagnosis.

  3. Szanse i ograniczenia stosowania strategii CSR w polskich przedsiêbiorstwach/The Chances and the Limitation of Applying the CSR Strategy in Polish Enterprises

    OpenAIRE

    Codogni, Iwona

    2012-01-01

    The topic of the article is the perspectives of CSR in Polish companies. The article contains the definition of corporate social responsibility, the state and dynamics of ethical reporting and the factors that can influence the dynamics of CSR in Poland – both in a favourable and adverse way.

  4. Post-transcriptional regulation on a global scale: form and function of Csr/Rsm systems.

    Science.gov (United States)

    Romeo, Tony; Vakulskas, Christopher A; Babitzke, Paul

    2013-02-01

    Originally described as a repressor of gene expression in the stationary phase of growth, CsrA (RsmA) regulates primary and secondary metabolic pathways, biofilm formation, motility, virulence circuitry of pathogens, quorum sensing and stress response systems by binding to conserved sequences in its target mRNAs and altering their translation and/or turnover. While the binding of CsrA to RNA is understood at an atomic level, new mechanisms of gene activation and repression by this protein are still emerging. In the γ-proteobacteria, small non-coding RNAs (sRNAs) use molecular mimicry to sequester multiple CsrA dimers away from mRNA. In contrast, the FliW protein of Bacillus subtilis inhibits CsrA activity by binding to this protein, thereby establishing a checkpoint in flagellum morphogenesis. Turnover of CsrB and CsrC sRNAs in Escherichia coli requires a specificity protein of the GGDEF-EAL domain superfamily, CsrD, in addition to the housekeeping nucleases RNase E and PNPase. The Csr system of E. coli contains extensive autoregulatory circuitry, which governs the expression and activity of CsrA. Interaction of the Csr system with transcriptional regulatory networks results in a variety of complex response patterns. This minireview will highlight basic principles and new insights into the workings of these complex eubacterial regulatory systems.

  5. CSR Communication Strategies for Organizational Legitimacy in Social Media

    DEFF Research Database (Denmark)

    Colleoni, Elanor

    2013-01-01

    the entire Twitter social graph, a network analysis was carried out to study the structural properties of the CSR community, such as the level of reciprocity, and advanced data mining techniques, i.e. topic and sentiment analysis, were carried out to investigate the communication dynamics. Findings...... is to investigate which corporate communication strategy adopted in online social media is more effective to create convergence between corporations' corporate social responsibility (CSR) agenda and stakeholders' social expectations, and thereby, to increase corporate legitimacy. Design/methodology/approach – Using....... Empirical findings show that, even when engaging in a dialogue, communication in social media is still conceived as a marketing practice to convey messages about companies. Originality/value – This paper originally investigates organizational legitimacy in the context of social media by applying advanced...

  6. CSR initiatives by companies for employees through social protection measures

    Directory of Open Access Journals (Sweden)

    Mohd Salleh Noor Akma

    2017-01-01

    Full Text Available Poverty has always been the main concern globally as it alienates and distresses particular groups of citizen that affects their emotion and psychological behaviour, and may have impact on the socio-economic aspect of the country. Hence, it is critical for the government to address the poverty problem, as this would lead to inequality. One way to minimise income inequality is through the provision of social protection to maintain the basic consumption and living standard of the needed members of the society. The government highlights the importance of increasing involvement of the private sector to improve social protection through their CSR programmes. Thus, the main purpose of this paper is to unearth the concept of social protection and its role in minimising inequality in the society as well as to develop an instrument to measure the social protection dimension of companies’ CSR activities.

  7. How Well are Water Companies Engaged in CSR?

    DEFF Research Database (Denmark)

    Lauesen, Linne Marie

    2014-01-01

    of management styles, behaviours and thinking from the private business sphere. This paper seeks to critically examine how water companies take part in the CSR discourse, by which institutional mechanisms this managerial “thinking” in terms of institutional “logics” has come about, and which adopted “meanings......; large size companies from the conservative and liberal market economy of the UK; large- and multinational companies from the USA and medium-, large- and multinationals from South Africa. Seven companies are chosen in each country from the smallest to the largest in order to obtain maximum variety......, the findings also question the credibility of this authenticity when most CSR-reports from the water companies are made without third party accreditation, without performance indicators and only through narratives that are hard to scrutinize. Research limitations/implications – The research has limitations...

  8. Status and Assessments of CSR GRACE Level-2 Data Products

    Science.gov (United States)

    Bettadpur, Srinivas; Kang, Zhigui; Nagel, Peter; Pastor, Rick; Poole, Steve; Ries, John; Save, Himanshu

    2015-04-01

    The joint NASA/DLR GRACE mission has successfully operated for more than 13 years, and has provided a remarkable record of global mass flux due to a large variety of geophysical and climate processes at various spatio-temporal scales. The University of Texas Center for Space Research (CSR) hosts the mission PI, and is responsible for delivery of operational (presently denoted as Release-05 or RL05) gravity field data products. In addition, CSR generates and distributes a variety of other gravity field data products, including products generated from the use of satellite laser ranging data. This poster will provide an overview of all these data products, their relative quality, potential applications, and future plans for their development and delivery.

  9. HIRFL-CSR commissioning in 2006 and 2007

    Institute of Scientific and Technical Information of China (English)

    XIA Jia-Wen; YUAN You-Jin; LIU Yong; YANG Jian-Cheng; XU Hu-Shan; XIAO Guo-Qing; YANG Xiao-Dong; ZHANG Wei; GAO Da-Qing; ZHOU Zhong-Zu; MAO Rui-Shi; MAO Li-Jun; HE Yuan; XU Zhe; YANG Ya-Qing; XIAO Chen; YIN Da-Yu; ZHAO Tie-Cheng; WU Jun-Xia; LI Guo-Hong; LI Jie; LI Peng; LI Ke; HU Zheng-Guo

    2009-01-01

    HIRFL-CSR,a flew heavy ion cooler-storage-ring system at IMP,had been in commissioning since the beginning of 2006.In the two years of 2006 and 2007 the CSR commissioning was finished,including the stripping injection(STI),electron-cooling with hollow electron beam,C-beam stacking with the combination of STI and e-cooling,the wide energy-range synchrotron ramping from 7 MeV/u to 1000 MeV/u by changing the RF harmonic-number at mid-energy,the multiple multi-turn injection(MMI),the beam accumulation with MMI and e-cooling for heavy-ion beams of Ar,Kr and Xe,the fast extraction from CSRm and single-turn injection to CSRe,beam stacking in CSRe and the RIBs mass-spectrometer test with the isochronous mode in CSRe by using the time-of-flight method.

  10. Prostate Cancer Clinical Trials Group - The University of Michigan Site

    Science.gov (United States)

    2014-06-01

    extracellular adhesion sites. Neoplasia 4:243–254 44. Shah RB, Mehra R, Chinnaiyan AM, Shen R, Ghosh D, Zhou M, Macvicar GR, Varambally S, Harwood J...Veganzones SB, Vidaurreta M, Martin M, Olivier C, DELO VB , Garcia-Saenz JA, Alfonso R, Arroyo M, Diaz-Rubio E (2009) Circulating tumor cells in solid...role of vascular endothelial growth factor. Proc Natl Acad Sci USA 1998; 95: 10820–10825. 25 Kumar R, Knick VB , Rudolph SK, Johnson JH, Crosby RM

  11. Globalization, CSR and business legitimacy in local relationships

    OpenAIRE

    Sundström, Agneta

    2009-01-01

    The business-society relationship is commonly viewed from a legitimacy perspective and refers to how society grants power over resources needed by business for survival and success. With globalization, business's need for traditional societal legitimacy has changed, which has made the social consequences of business actions more obvious. Corporate social responsibility (CSR) has emerged as a global trend, presenting various social motives and economic gains for business to voluntarily establi...

  12. Proceedings CSR 2010 Workshop on High Productivity Computations

    CERN Document Server

    Ablayev, Farid; Vasiliev, Alexander; 10.4204/EPTCS.52

    2011-01-01

    This volume contains the proceedings of the Workshop on High Productivity Computations (HPC 2010) which took place on June 21-22 in Kazan, Russia. This workshop was held as a satellite workshop of the 5th International Computer Science Symposium in Russia (CSR 2010). HPC 2010 was intended to organize the discussions about high productivity computing means and models, including but not limited to high performance and quantum information processing.

  13. Development of Corporate Social Responsibility (CSR) in India

    OpenAIRE

    Ravi Shankar; Leslie Chadwick; Shahzad Ghafoor; Farooq Khan

    2011-01-01

    The interest in Corporate Social Responsibility (CSR), which recognizes thatcompanies have obligations that extend beyond short-run profit maximization toinclude notions of social and environmental concern, has increased considerably inrecent decades. The globalization of the world economy and the related tradeliberalization has brought forward a discussion of the importance of business as anactor in the development of society. The aim of this research is to analyse theeffectiveness of the CS...

  14. THE YIN AND YANG OF CSR ETHICAL BRANDING

    Directory of Open Access Journals (Sweden)

    Ellisha Nasruddin

    2007-01-01

    Full Text Available Within the current discourse and the often overly-commercialized hyperbole of branding and positioning, there is a particular area that has not been given due attention. Yet, with the rapid changes and the multiple crises of present-day realities, a frequently neglected area, emerges as vitally imperative. The troubles can be seen in both large as well as small businesses within Malaysia. This article, thus, aims to bring back ethics, one of the management blind-spots, into the center stage of branding and organizational transformation. The objectives of this article are two-fold: (1 to build a discussion on the value and importance of ethical branding through CSR initiatives and (2 to present a CSR ethical branding (CSR-EB framework which delineates the content (yin and context (yang, comprising seven pillars: pillar of ethical core, pillar of inner stakeholders, pillar of products and services, pillar of outer stakeholders, pillar of cultural context, pillar of spatial context, and pillar of temporal context.

  15. THE EVOLUTION OF CSR ACROSS LISTED BRAZILIAN FIRMS

    Directory of Open Access Journals (Sweden)

    Ana Gisbert

    2012-03-01

    Full Text Available This paper analyzes the improvements in corporate social responsibility (CSR among Brazilian companies listed on the Sao Paulo Stock Exchange – Bovespa, focusing on the type of social and environmental projects together with the amount of investments over the period 2003-2007. The empirical analysis is based on the content of the CSR reports of 48 companies, among them those making up the Bovespa’s Corporate Sustainability Index. All the identified social and environmental projects were classified into eleven categories and three investment categories: internal, external and environmental. The results show the need to standardize the CSR reports due to the absence of uniformity among the sample firms. The investment data reveal a significant increase in external investment projects, followed by the internal category. The results of the environmental category reveal only a moderate increase due to the reduction of the environmental investment in the petroleum industry. Overall, the results reveal that companies tend to invest in projects strongly linked to their main activities.

  16. Corporate Social Responsibility (CSR: A Scale Development Study in Iran

    Directory of Open Access Journals (Sweden)

    Kambiz Heidarzadeh Hanzaee

    2013-07-01

    Full Text Available The present research aims to explore a scale of Corporate Social Responsibility (CSR in Iran. In this way, it reviews the literature exist on corporate social responsibility, gathers data and analyzes the data to test the emerging trends. After confirmation of reliability, factor analysis and multi dimensional scaling are used to an established survey instrument. Finally CSR was achieved as a construct with five dimensions: obligation to employees, obligation to customers and markets, obligation to social programs and natural environment, obligation to laws and regulations and obligation to society. These five dimensions represent the corporate accountability to some different groups of its stakeholders. In this study the convenient samples of managers and employees used in collecting data and developing the scale, however in exploratory studies, this type of sampling can be acceptable. Nevertheless, some limitations should be taken into consideration, while interpreting the findings of the study and generalizing them to general business environment. Therefore enlarging the sample size and using a random sampling method of managers and employees in future studies has to make Corporate Social Responsibility (CSR scale more useful and enhance the generalization.

  17. The Differential Effects of Social Media Sites for Promoting Cancer Risk Reduction.

    Science.gov (United States)

    Lauckner, Carolyn; Whitten, Pamela

    2016-09-01

    Social media are potentially valuable tools for disseminating cancer education messages, but the differential effects of various sites on persuasive outcomes are unknown. In an effort to inform future health promotion, this research tested the effects of Facebook, YouTube, Twitter, and blogs for delivering a cancer risk reduction message. Using an experimental design, participants were randomly placed in several conditions that delivered the same message but with different forms of social media. Effects on comprehension and attitudes were examined, as they are important variables in the behavior change process. YouTube led to higher comprehension and stronger attitudes toward cancer risk reduction than Twitter, but there were no differences between other sites. Additionally, YouTube led to stronger attitudes toward cancer risk reduction as compared to Facebook, but not any other sites. These results demonstrate that, even if the message is kept constant, the form of social media used to deliver content can have an effect on persuasive outcomes. More research is needed to determine the mechanisms behind the differences found, however. Altogether, this line of research is valuable for any individuals seeking to use social media for health promotion purposes and could have direct implications for the development of cancer risk reduction campaigns.

  18. Polymorphisms in MicroRNA Binding Sites Predict Colorectal Cancer Survival

    Science.gov (United States)

    Yang, Ying-Pi; Ting, Wen-Chien; Chen, Lu-Min; Lu, Te-Ling; Bao, Bo-Ying

    2017-01-01

    Background: MicroRNAs (miRNAs) mediate negative regulation of target genes through base pairing, and aberrant miRNA expression has been described in cancers. We hypothesized that single nucleotide polymorphisms (SNPs) within miRNA target sites might influence clinical outcomes in patients with colorectal cancer. Methods: Sixteen common SNPs within miRNA target sites were identified, and the association between these SNPs and overall survival was assessed in colorectal cancer patients using Kaplan-Meier analysis, Cox regression model, and survival tree analysis. Results: Survival tree analysis identified a higher-order genetic interaction profile consisting of the RPS6KB1 rs1051424 and ZNF839 rs11704 that was significantly associated with overall survival. The 5-year survival rates were 74.6%, 62.7%, and 57.1% for the low-, medium-, and high-risk genetic profiles, respectively (P = 0.006). The genetic interaction profile remained significant even after adjusting for potential risk factors. Additional in silico analysis provided evidence that rs1051424 and rs11704 affect RPS6KB1 and ZNF839 expressions, which in turn is significantly correlated with prognosis in colorectal cancer. Conclusion: Our results suggest that the genetic interaction profiles among SNPs within miRNA target sites might be prognostic markers for colorectal cancer survival. PMID:28138309

  19. Repeated occurrence of second primary lung cancer at different sites in trachea: a case report.

    Science.gov (United States)

    Lee, Yong Chul; Park, Yun Ji; Gang, Su Jin; Chung, Myung Ja; Kim, So Ri

    2015-05-01

    Multiple or second primary lung cancers can develop at any sites in the lung with same or different histologic types, synchronously and/or metachronously. In case of metachronous occurrence of the second primary lung cancer, it is easy to confuse with the primary lung cancer as a recurrence of precedent lung malignancy treated successfully or metastasis. Previous reports have demonstrated that majority of the second primary lung malignancies have same histologic types regardless of their developing time and location. However, the repeated occurrence of the second primary lung malignancy, in particular with the different histologic features, is a very rare condition.A 62-year-old male who had past history of squamous cell carcinoma treated with surgery and adjuvant chemotherapy and the recurrence of lung malignancy on the trachea, which was also resected successfully visited our hospital due to blood tinged sputum. Evaluation using bronchoscopy and chest computed tomography revealed the tracheal mass looked similar grossly to the previous recurred tracheal mass that was resected surgically. Unexpectedly, the newly developed tracheal mass was confirmed as small cell lung cancer, the different histologic type from previous ones.In this report, we describe an interesting case of subsequent occurrence of second primary lung cancers showing histologic shifting at different sites in trachea, suggesting that it is important for physician to make an effort to identify the histologic characteristics of second primary lung cancers for the correct and adequate treatment no matter what they exhibit similar gross morphology.

  20. ALERT. Adverse late effects of cancer treatment. Vol. 2. Normal tissue specific sites and systems

    Energy Technology Data Exchange (ETDEWEB)

    Rubin, Philip; Constine, Louis S. [Univ. Rochester Medical Center, NY (United States). Dept. of Radiation Oncology; Marks, Lawrence B. (ed.) [Univ. North Carolina and Lineberger, Comprehensive Cancer Center, Chapel Hill, NC (United States). Dept. of Radiation Oncology

    2014-09-01

    Comprehensively documents potential late effects in all the normal tissue sites in the human body. Considers in detail the detection, diagnosis, management and prevention of effects and discusses prognostic outcomes. Clearly presents radiation risk factors and interactions with chemotherapy effects. Provides the most current evidence-based medicine for cancer care survivorship guidelines. The literature on the late effects of cancer treatment is widely scattered in different journals since all major organ systems are affected and management is based on a variety of medical and surgical treatments. The aim of ALERT - Adverse Late Effects of Cancer Treatment is to offer a coherent multidisciplinary approach to the care of cancer survivors. The central paradigm is that cytotoxic multimodal therapy results in a perpetual cascade of events that affects each major organ system differently and is expressed continually over time. Essentially, radiation and chemotherapy are intense biologic modifiers that allow for cancer cure and cancer survivorship but accelerate senescence of normal tissues and increase the incidence of age-related diseases and second malignant tumors. Volume 2 of this two-volume work comprehensively documents potential late effects in all the normal tissue anatomic sites in the human body. The detection, diagnosis, management and prevention of effects are all considered in detail, and prognostic outcomes are discussed. Radiation risk factors and interactions with chemotherapy effects are clearly presented. The text is accompanied by numerous supportive illustrations and tables.

  1. Demystifying relationship between Corporate Social Responsibility (CSR and financial performance: An Indian business perspective

    Directory of Open Access Journals (Sweden)

    Richa Gautam

    2016-12-01

    Full Text Available Corporate Social Responsibility (CSR is a desirable approach considering it reduces risks, increases brand value, improves transparency, and has a possible impact on the financial health of the business. Initiated as an act of philanthropy, it has recently become mandatory as a part of the Companies Act, 2013 in India which mandates CSR spending. The study had an objective to validate that CSR disclosures lead to better financial performance of a company and vice-versa. The study analyzed the relationship between CSR disclosure and financial performance and vice versa using various approaches viz., exploratory to understand the trends and practices and statistical by adopting multiple regression modelling techniques. The results of the study reveal that the company’s financial performance (profitability has a cause and effect relationship with the CSR disclosure and vice versa, which substantiated the theories predicting that CSR can affect the financial performance of the company.

  2. Introducing value-based framing as a strategy for communicating CSR

    DEFF Research Database (Denmark)

    Schmeltz, Line

    2014-01-01

    Purpose – The purpose of this paper is to test how framing of CSR messages, based on a value-theoretical framework, impacts consumer perception of the CSR message. Design/methodology/approach – Quantitative study in the form of an online survey strongly inspired by classical experimental design....... Findings – Findings demonstrate that explicit communication of CSR framed as a corporate competence, and to some extent also as something personally relevant to the receivers, positively impacts evaluations of CSR messages and the companies behind them. Research limitations/implications – Findings indicate...... that CSR messages could increasingly emphasize corporate competence with a lesser focus on moral ideas and commitments, and that framing strategies can be effective in creating CSR messages that will be positively evaluated by young consumers. Originality/value – This study contributes by providing new...

  3. Incidence of Breast, Prostate, Testicular, and Thyroid Cancer in Italian Contaminated Sites with Presence of Substances with Endocrine Disrupting Properties

    Directory of Open Access Journals (Sweden)

    Marta Benedetti

    2017-03-01

    Full Text Available The aim of the present study was to investigate the incidence of breast (females, prostate, testicular, and thyroid cancer in the Italian National Priority Contaminated Sites (NPCSs, served by cancer registries, where the presence of endocrine disruptors (EDs, reported to be linked to these tumours, was documented. Evidence of carcinogenicity of EDs present in NPCSs was assessed based on evaluation by international scientific institutions and committees. Standardized Incidence Ratios (SIRs were computed for each NPCS and cancer site between 1996 and 2005. Excess incidence of one or more cancer site studied was found in twelve out of fourteen NPCSs. Significantly increased SIRs were found for breast cancer in eight NPCSs, for prostate cancer in six, for thyroid cancer (both gender in four, and for testicular cancer in two. Non-significantly increased SIRs were found in five NPCSs for testicular cancer and in two for thyroid cancer (males. In a small number of instances a significant deficit was reported, mainly for thyroid and prostate cancer. Although increased incidence of one or more cancer sites studied were found in several NPCSs, the ecological study design and the multifactorial aetiology of the considered tumours do not permit concluding causal links with environmental contamination. Regarding the observation of some excesses in SIRs, continuing epidemiological surveillance is warranted.

  4. Incidence of Breast, Prostate, Testicular, and Thyroid Cancer in Italian Contaminated Sites with Presence of Substances with Endocrine Disrupting Properties.

    Science.gov (United States)

    Benedetti, Marta; Zona, Amerigo; Beccaloni, Eleonora; Carere, Mario; Comba, Pietro

    2017-03-29

    The aim of the present study was to investigate the incidence of breast (females), prostate, testicular, and thyroid cancer in the Italian National Priority Contaminated Sites (NPCSs), served by cancer registries, where the presence of endocrine disruptors (EDs), reported to be linked to these tumours, was documented. Evidence of carcinogenicity of EDs present in NPCSs was assessed based on evaluation by international scientific institutions and committees. Standardized Incidence Ratios (SIRs) were computed for each NPCS and cancer site between 1996 and 2005. Excess incidence of one or more cancer site studied was found in twelve out of fourteen NPCSs. Significantly increased SIRs were found for breast cancer in eight NPCSs, for prostate cancer in six, for thyroid cancer (both gender) in four, and for testicular cancer in two. Non-significantly increased SIRs were found in five NPCSs for testicular cancer and in two for thyroid cancer (males). In a small number of instances a significant deficit was reported, mainly for thyroid and prostate cancer. Although increased incidence of one or more cancer sites studied were found in several NPCSs, the ecological study design and the multifactorial aetiology of the considered tumours do not permit concluding causal links with environmental contamination. Regarding the observation of some excesses in SIRs, continuing epidemiological surveillance is warranted.

  5. Cancer and birth defects surveillance system for communities around the Savannah River Site. Annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Dunbar, J.B.

    1993-05-01

    This technical report presents the age-adjusted total, and race and sex specific geographic patterns of cancer mortality for South Carolina (SC) counties utilizing the 1953--1987 average annual age-adjusted mortality rates (AAMRs). The mortality information was obtained from the State Cancer Control Map and Data Program produced by the National Cancer Institute , Centers for Disease Control and the American Cancer Society. The AAMRs for selected primary sites are classified as significantly different or not significantly different from the corresponding United States and SC mortality rates. Categories for classification of the rates are determined using 95% confidence intervals. Geographic patterns of significantly high county AAMRs are identified and discussed. Individual county rates are not emphasized. The terminology, mortality rates used throughout this report pertains to the 1953--1987 AAMRS.

  6. Cancer and birth defects surveillance system for communities around the Savannah River Site

    Energy Technology Data Exchange (ETDEWEB)

    Dunbar, J.B.

    1993-05-01

    This technical report presents the age-adjusted total, and race and sex specific geographic patterns of cancer mortality for South Carolina (SC) counties utilizing the 1953--1987 average annual age-adjusted mortality rates (AAMRs). The mortality information was obtained from the State Cancer Control Map and Data Program produced by the National Cancer Institute , Centers for Disease Control and the American Cancer Society. The AAMRs for selected primary sites are classified as significantly different or not significantly different from the corresponding United States and SC mortality rates. Categories for classification of the rates are determined using 95% confidence intervals. Geographic patterns of significantly high county AAMRs are identified and discussed. Individual county rates are not emphasized. The terminology, mortality rates used throughout this report pertains to the 1953--1987 AAMRS.

  7. On dissemination mechanism of corporate social responsibility (CSR): Analysis with agent simulation

    OpenAIRE

    Hashimoto, Takashi; Shinohara, Naoto; Egashira, Susumu

    2009-01-01

    Corporate Social Responsibility (CSR), such as pro-environmental behaviour and fair trade, is a kind of normative behaviour by private companies to provide a quasi-public good. We study dissemination mechanism of CSR with a multi-agent model in which corporation agents and consumer agents interact with each other. We show that the mechanism to disseminate CSR is a positive feedback between the corporations' popularity seeking behaviour and the consumers' social learning in which ...

  8. The Limits of Corporate Social Responsibility: Techniques of Neutralization, Stakeholder Management and Political CSR.

    Science.gov (United States)

    Fooks, Gary; Gilmore, Anna; Collin, Jeff; Holden, Chris; Lee, Kelley

    2013-01-01

    Since scholarly interest in corporate social responsibility (CSR) has primarily focused on the synergies between social and economic performance, our understanding of how (and the conditions under which) companies use CSR to produce policy outcomes that work against public welfare has remained comparatively under-developed. In particular, little is known about how corporate decision-makers privately reconcile the conflicts between public and private interests, even though this is likely to be relevant to understanding the limitations of CSR as a means of aligning business activity with the broader public interest. This study addresses this issue using internal tobacco industry documents to explore British-American Tobacco's (BAT) thinking on CSR and its effects on the company's CSR Programme. The article presents a three-stage model of CSR development, based on Sykes and Matza's theory of techniques of neutralization, which links together: how BAT managers made sense of the company's declining political authority in the mid-1990s; how they subsequently justified the use of CSR as a tool of stakeholder management aimed at diffusing the political impact of public health advocates by breaking up political constituencies working towards evidence-based tobacco regulation; and how CSR works ideologically to shape stakeholders' perceptions of the relative merits of competing approaches to tobacco control. Our analysis has three implications for research and practice. First, it underlines the importance of approaching corporate managers' public comments on CSR critically and situating them in their economic, political and historical contexts. Second, it illustrates the importance of focusing on the political aims and effects of CSR. Third, by showing how CSR practices are used to stymie evidence-based government regulation, the article underlines the importance of highlighting and developing matrices to assess the negative social impacts of CSR.

  9. Private CSR Activities in Oligopolistic Markets: Is there any room for Regulation?

    OpenAIRE

    Evangelos Mitrokostas; Emmanuel Petrakis

    2008-01-01

    The present paper examines the conditions under which the regulator can complement the provision of Corporate Social Responsibility (CSR) activities by private firms in an oligopolistic market. Our main finding is that if there is no credible information disclosure about SR characteristics of the firms' products to consumers, no firm will have incentives to undertake CSR effort in equilibrium. However, if the necessary information about the CSR aspects of each firm's product, otherwise unobse...

  10. Corporate Sustainability/CSR Communications and Value Creation : A Marketing Approach

    OpenAIRE

    Mohamed, Bibri

    2008-01-01

    The purpose of this study is to explore the current practices in corporate sustainability/CSR communications and how this trend contributes to corporate value creation. More specifically, this study looks at this subject from the angle of how companies can use corporate sustainability/CSR communications in marketing activities to attain corporate marketing objectives. To achieve the aim of this study, an examination of the current practices in corporate sustainability /CSR communications was ...

  11. The influence of transverse CSR structure on headquarters/subsidiary integration

    OpenAIRE

    Luciano Barin Cruz; Eugênio Ávila Pedrozo; Vania de Fátima Barros Estivalete; Debora Nayar Hoff

    2010-01-01

    Some studies have already highlighted the effects of the introduction of Corporate Social Responsibility [CSR] projects into Multinational Corporations’ [MNC] strategies. However, little attention has been paid to the influence of transverse CSR structure on headquarters/subsidiary integration. In this article, we begin with the following question: What is the influence of the introduction of a centralized/decentralized structure on conducting a CSR strategy in a MNC? Our main objective is to...

  12. CSR Strategies in Greater China: Global, East Asian, American, European Style?

    Directory of Open Access Journals (Sweden)

    Heiduk Guenter

    2014-10-01

    Full Text Available The concept of Corporate Social Responsibility emerged in the United States and spread to Europe and Asia while being adapted to national/local characteristics. Since borders between markets and societies are blurring and globalization is promoting MNCs which find themselves acting in hybrid societies, international institutions put efforts into the development and moral acceptance of global CSR standards. The scientific interest in CSR focused on the conflicts between company returns and benefits for society. The resulting concepts of performance-oriented, awareness-oriented and welfare-oriented CSR should facilitate the evaluation of CSR strategies implemented by MNCs. In research on the cultural dimensions of economies, it might be possible to allocate geographically the three concepts. Regarding the newly emerging Chinese MNCs, the paper aims to shed light on which concept they follow. On the one hand, CSR concepts of American and/or European MNCs that are present in China might serve as a role model; on the other hand, by learning from Taiwanese/ Hong Kong MNCs, a “greater China CSR approach” might emerge. Empirical studies and own field research suggest that compared to American and European companies, CSR is less deeply rooted in Chinese companies. Furthermore, significant differences between Mainland China, Hong Kong and Taiwanese companies indicate that a Greater Chinese CSR approach does not yet exist. Therefore, it cannot be assumed that American and European CSR concepts will experience a Chinese influence in the near future.

  13. Comparative functional characterization of the CSR-1 22G-RNA pathway in Caenorhabditis nematodes.

    Science.gov (United States)

    Tu, Shikui; Wu, Monica Z; Wang, Jie; Cutter, Asher D; Weng, Zhiping; Claycomb, Julie M

    2015-01-01

    As a champion of small RNA research for two decades, Caenorhabditis elegans has revealed the essential Argonaute CSR-1 to play key nuclear roles in modulating chromatin, chromosome segregation and germline gene expression via 22G-small RNAs. Despite CSR-1 being preserved among diverse nematodes, the conservation and divergence in function of the targets of small RNA pathways remains poorly resolved. Here we apply comparative functional genomic analysis between C. elegans and Caenorhabditis briggsae to characterize the CSR-1 pathway, its targets and their evolution. C. briggsae CSR-1-associated small RNAs that we identified by immunoprecipitation-small RNA sequencing overlap with 22G-RNAs depleted in cbr-csr-1 RNAi-treated worms. By comparing 22G-RNAs and target genes between species, we defined a set of CSR-1 target genes with conserved germline expression, enrichment in operons and more slowly evolving coding sequences than other genes, along with a small group of evolutionarily labile targets. We demonstrate that the association of CSR-1 with chromatin is preserved, and show that depletion of cbr-csr-1 leads to chromosome segregation defects and embryonic lethality. This first comparative characterization of a small RNA pathway in Caenorhabditis establishes a conserved nuclear role for CSR-1 and highlights its key role in germline gene regulation across multiple animal species.

  14. The Age of Responsibility: CSR 2.0 and the New DNA of Business

    Directory of Open Access Journals (Sweden)

    Wayne Visser

    2014-09-01

    Full Text Available This paper argues that CSR, as a business, governance and ethics system, has failed. This assumes that success or failure is measured in terms of the net impact (positive or negative of business on society and the environment. The paper contends that a different kind of CSR is needed if we are to reverse the current direction of many of the world’s most pressing social, environmental and ethical trends. The first part of the paper reviews business’s historical progress over the Ages and Stages of CSR: moving through the Ages of Greed, Philanthropy, Marketing and Management, using defensive, charitable, promotional and strategic CSR approaches respectively. The second part of the paper examines the Three Curses of Modern CSR (incremental, peripheral and uneconomic, before exploring what CSR might look like in an emerging Age of Responsibility. This new CSR – called systemic or radical CSR, or CSR 2.0 – is based on five principles (creativity, scalability, responsiveness, glocality and circularity and forms the basis for a new DNA model of responsible business, built around the four elements of value creation, good governance, societal contribution and environmental integrity.

  15. Evaluation of the prognostic benefit of identifying the probable primary site in cancer of unknown primary

    Directory of Open Access Journals (Sweden)

    Das Joyutpal

    2015-09-01

    Full Text Available With the development of site-specific cancer therapy, identifying the primary origin allows the oncologist to personalise therapy for patients with the cancer of unknown primaries (CUPs. At present, immunohistochemistry (IHC screening is the standard method used to postulate the primary site in CUP. In this retrospective study, we evaluated the prognostic benefit of identifying the primary site in CUP. All 84 patients who presented with suspected CUP to the Royal Stoke University Hospital between 2011 and 2012 were included in our study. Forty-eight percent (40/84 of these patients were unable to undergo necessary investigations to identify primary sites because of poor performance status. IHC screening was able to postulate the primary site in 59% (26/44 of the remaining patients with confirmed CUP. Therefore, the primary site was not identified in a significant proportion of patients with CUP. The median survival of confirmed CUP with probable primary site was 2.0 months (95% confidence interval (CI: 1.2 to 2.9 months, whereas the median survival of confirmed CUP with no probable primary site was 4.1 months (95% CI: 1.5 to 9.7 months. This difference in survival time was statistically significant. In addition, using the Cox regression model, we found that patients with confirmed CUP with primary sites had prognostically unfavourable diseases with a shorter median survival, regardless of the age of disease onset, gender, sites of metastases or number of metastases. One approach to improve the survival would be to start systemic therapy at the earliest possible opportunity rather than waiting for all investigation results, such as IHC.

  16. Single nucleotide polymorphisms in microRNA binding sites of oncogenes: implications in cancer and pharmacogenomics.

    Science.gov (United States)

    Manikandan, Mayakannan; Munirajan, Arasambattu Kannan

    2014-02-01

    Cancer, a complex genetic disease involving uncontrolled cell proliferation, is caused by inactivation of tumor suppressor genes and activation of oncogenes. A vast majority of these cancer causing genes are known targets of microRNAs (miRNAs) that bind to complementary sequences in 3' untranslated regions (UTR) of messenger RNAs and repress them from translation. Single Nucleotide Polymorphisms (SNPs) occurring naturally in such miRNA binding regions can alter the miRNA:mRNA interaction and can significantly affect gene expression. We hypothesized that 3'UTR SNPs in miRNA binding sites of proto-oncogenes could abrogate their post-transcriptional regulation, resulting in overexpression of oncogenic proteins, tumor initiation, progression, and modulation of drug response in cancer patients. Therefore, we developed a systematic computational pipeline that integrates data from well-established databases, followed stringent selection criteria and identified a panel of 30 high-confidence SNPs that may impair miRNA target sites in the 3' UTR of 54 mRNA transcripts of 24 proto-oncogenes. Further, 8 SNPs amidst them had the potential to determine therapeutic outcome in cancer patients. Functional annotation suggested that altogether these SNPs occur in proto-oncogenes enriched for kinase activities. We provide detailed in silico evidence for the functional effect of these candidate SNPs in various types of cancer.

  17. Tumor characteristics and metastatic sites may predict bevacizumab efficacy in the first-line treatment of metastatic colorectal cancer

    OpenAIRE

    Varol, Umut; Oktay, Esin; YILDIRIM, Mustafa; SURMELI, ZEKI GOKHAN; Dirican, Ahmet; Meydan, Nezih; KARACA, BURCAK; Karabulut, Bulent; Uslu, Ruchan

    2013-01-01

    Colorectal cancer (CRC) is among the most frequently diagnosed cancers and a major cause of cancer-related mortality worldwide. The aim of the present study was to determine whether there was an improvement in the time to disease progression (TTP) in patients with metastatic colorectal cancer (mCRC) treated with first-line bevacizumab plus chemotherapy, according to tumor characteristics and metastatic sites. Tumor characteristics and tumor burden were considered to be predictive markers of t...

  18. Alkynol natural products target ALDH2 in cancer cells by irreversible binding to the active site.

    Science.gov (United States)

    Heydenreuter, Wolfgang; Kunold, Elena; Sieber, Stephan A

    2015-11-11

    Falcarinol and stipudiol are natural products with potent anti-cancer activity found in several vegetables. Here, we use a chemical proteomic strategy to identify ALDH2 as a molecular target of falcarinol in cancer cells and confirm enzyme inhibition via covalent alkylation of the active site. Furthermore, the synthesis of stipudiol led to the observation that ALDH2 exhibits preference for alkynol-based binders. Inhibition of ALDH2 impairs detoxification of reactive aldehydes and limits oxidative stress response, two crucial pathways for cellular viability.

  19. Impact of the difference in surgical site on the physique in gastrointestinal tract cancer patients.

    Science.gov (United States)

    Hara, Tsuyoshi; Kubo, Akira; Kogure, Eisuke; Ishii, Takaya

    2016-01-01

    [Purpose] The purpose of the present study was to observe physical function, physique (only BMI), and nutrition status (evaluated by serum albumin levels) from before surgery to after discharge among perioperative patients with gastrointestinal tract cancer and to examine the effect of difference in surgical site (i.e., stomach, colon, and rectum) in these patients. [Subjects and Methods] The study subjects were 70 patients who underwent surgical treatment for gastrointestinal tract cancer [36 males and 34 females, aged 59.3 ± 11.4 years (mean ± SD)]. The subjects were classified into three levels according to surgical site (stomach, colon, and rectum). We evaluated patients' physical function, physique, and nutrition status in the three points: before surgery, after surgery, and after discharge. The 6-minute walk distance was measured for physical function. Body mass index was measured for physique. The serum albumin level was measured for nutrition status. [Results] Significant declines in 6-minute walk distance, body mass index, and serum albumin were observed after surgery among the study subjects. In addition, a significant decline in body mass index was observed after discharge compared with before surgery. Regarding body mass index, a significant interaction between surgical site and evaluation times was observed for ANOVA. [Conclusion] These results suggest that BMI after discharge is significantly less than that before surgery and that body mass index changes from before surgery to after surgery are efficacy the difference of surgical site in patients who undergo surgical treatment for gastrointestinal tract cancer.

  20. Determinants of Web-based CSR Disclosure in the Food Industry

    Directory of Open Access Journals (Sweden)

    Florian Sommer

    2015-01-01

    Full Text Available Purpose –Web-based CSR disclosure provides a variety of advantages for firms. Determining factors for web-based CSR disclosure have been analyzed in several papers. However, only limited research has been conducted on both, the food industry and small and midsized enterprises. This paper is one contribution to fill this gap as we investigate web-based CSR communication of food processors including SME.Design/methodology/approach – We analyzed corporate communication on the websites of 71 food producers from North Rhine-Westphalia, Germany using dictionary-based content analysis. Based on an ordered logit model the relationship between CSR communication and size, profitability, indebtedness and closeness to market was estimated. Economic data were obtained from the commercial database DAFNE.Findings – Our results reveal that larger firms provide relatively more CSR information than smaller firms. There was no significant relationship between CSR disclosure and profitability or indebtedness of a company and an ambiguous relationship with regard to the determinant ‘closeness to market’. Regarding the different areas of communication we found that social compared to environmental aspects were underrepresented.Practical implications – Social aspects of CSR could be used for differentiation in the market. Furthermore, as smaller firms provide relatively less information on CSR it might be worthwhile to analyze the central impediments for CSR communication for those companies.Originality/Value – This paper contributes to the ongoing discussion about firms’ CSR communication. From a convenience sample of 71 food processing firms, including SME, it provides insight regarding the determinants for CSR disclosure on firms’ websites. With the focus on the food industry and the inclusion of SME we contribute with our study to two under-researched areas.

  1. Introducing CSR - The Missing Ingredient in the Land Reform Recipe?

    Directory of Open Access Journals (Sweden)

    Henk J Kloppers

    2014-05-01

    Full Text Available In reaction to the unequal land ownership brought about by decades of apartheid, the first democratically elected government embarked on an extensive land reform programme - a programme consisting of the three constitutionally protected pillars: restitution, redistribution and tenure reform. The aim of this programme is not only to provide for restitution to persons who lost their land as a result of racially based measures, but also provide previously disadvantaged South Africans with access to land in order to address the unequal land ownership. This research focuses on the restitution and redistribution pillars of the land reform programme. The progress made in terms of both these sub-programmes has been disappointing. With reference to redistribution the government has set the target to redistribute 30% of white owned commercial agricultural land to black persons by 2014. To date, less than 10% of this target has been achieved and all indications are that the overwhelming majority of land which has been redistributed is not being used productively or have fallen into a state of total neglect. The state of the redistributed land can be attributed to a variety of causes, with the main cause being the government's inability to provide proper post-settlement support to land reform beneficiaries. Against this background it is clear that alternative options have to be identified in order to improve the result of land reform. This article identifies corporate social responsibility (CSR as one of the missing ingredients in the recipe for a successful land reform programme. The article introduces CSR and discusses the business case for CSR; identifies its benefits; considers its possible limitations; and examines the major drivers behind the notion. From the discussion of these topics it will become evident that an assumption of social responsibility by businesses in especially the agricultural sector might contribute to an improved land reform

  2. Progress of UHV System of HIRFL-CSR in 2001

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The great progress of the ultra-high vacuum system of HIRFL-CSR was obtained in 2001.1. Many testing cycles were done on the first dipole chamber prototype with different baking temperatures.250℃ was considered a suitable baking temperature for the vacuum chambers,which can reduce the outgassing rate of the chambers effectively and was not high enough to damage the magnet coils during the bake-out process.At the same time, the residual gas analyzers and vacuum gauges from several companies were tested. ...

  3. The Carbon Storage Regulator (Csr) System Exerts a Nutrient-Specific Control over Central Metabolism in Escherichia coli Strain Nissle 1917

    OpenAIRE

    Olga Revelles; Pierre Millard; Jean-Philippe Nougayrède; Ulrich Dobrindt; Eric Oswald; Fabien Létisse; Jean-Charles Portais

    2013-01-01

    The role of the post-transcriptional carbon storage regulator (Csr) system in nutrient utilization and in the control of the central metabolism in E. coli reference commensal strain Nissle 1917 was investigated. Analysis of the growth capabilities of mutants altered for various components of the Csr system (csrA51, csrB, csrC and csrD mutations) showed that only the protein CsrA - the key component of the system - exerts a marked role in carbon nutrition. Attenuation of CsrA activity in the c...

  4. Splice site mutations in mismatch repair genes and risk of cancer in the general population

    DEFF Research Database (Denmark)

    Thomsen, Mette; Nordestgaard, Børge G; Tybjærg-Hansen, Anne;

    2013-01-01

    We tested the hypothesis that splice site variations in MSH2 and MLH1 are associated with increased risk of hereditary non-polyposis colorectal cancer (HNPCC) and of cancer in general in the general population. In a cohort of 154 HNPCC patients with sequenced MSH2 and MLH1, we identified four...... possible splice-site mutations, which we subsequently genotyped in more than 9,000 individuals from the general population. Allele frequencies in the general population were 0 % for 942+3A>T in MSH2, 0.05 % for 307-19A>G, 0.005 % for 1,667+(2-8)del(taaatca);ins(attt), and 4.4 % for 1039-8T>A in MLH1. Odds...

  5. Prostate cancer guidelines on Web 2.0-based sites: the screening dilemma continues online.

    Science.gov (United States)

    Friedman, Daniela B; Koskan, Alexis; Rose, India D

    2011-03-01

    Little is known about prostate cancer (PrCA) screening information on participatory, interactive, and consumer-generated websites collectively referred to as Web 2.0. A content analysis was conducted of PrCA resources on four highly trafficked Web 2.0 social bookmarking sites. A total of 127 webpages were analyzed. Most content was from news websites (48.9%) and blogs (37.8%). PrCA screening was mentioned on 95.3% of pages; only 30.7% discussed the prostate-specific antigen test. Less than half (43.8%) mentioned current screening guidelines. PrCA content is inconsistent on Web 2.0 sites. Future research should assess the readability and usability of Web 2.0 cancer resources.

  6. Sustainability in a global context: How does local factor affect the outcomes of CSR activities in international business units?

    DEFF Research Database (Denmark)

    Thomsen, Christa; Lauring, Jakob

    In recent years CSR has become increasingly important for the activities and branding of MNCs. While some studies have investigated CSR management and branding in domestic situations, fewer studies exist in the case of international business units (subsidiaries, joint ventures, and franchises...... as CSR branding outcomes). Our findings show that local values were positively associated with external CSR engagement and that employee relations were positively related to both internal and external CSR engagement. None of the local factors were significantly associated with CSR branding outcomes......). In this study, we use a sample consisting of 119 Danish business units that are located in China. We set out to investigate the relationship between local factors (the local business unit’s Chinese values and internal employee relations in the unit) and CSR outcomes (internal and external CSR engagement as well...

  7. Ovarian cancer: the Fallopian tube as the site of origin and opportunities for prevention

    Directory of Open Access Journals (Sweden)

    Sophia HL George, PhD

    2016-05-01

    Full Text Available High-grade serous carcinoma is the most common and aggressive histotype of epithelial ovarian cancer, and it is the predominant histotype associated with hereditary breast and ovarian cancer syndrome (HBOC. Mutations in BRCA1 and BRCA2 are responsible for most of the known causes of HBOC, while mutations in mismatch repair genes and several genes of moderate penetrance are responsible for the remaining known hereditary risk. Women with a history of familial ovarian cancer or with known germline mutations in highly penetrant genes are offered the option risk-reducing surgery, which involves the removal of the ovaries and fallopian tubes (salpingo-oophorectomy. Growing evidence now supports the fallopian tube epithelia as an etiological site for the development of HGSC and consequently, salpingectomy alone is emerging as a prophylactic option. This review discusses the site of origin of epithelial ovarian cancer, the rationale for risk-reducing salpingectomy in the high-risk population and opportunities for salpingectomy in the low-risk population.

  8. The glass ceiling of corporate social responsibility : Consequences of a business case approach towards CSR

    NARCIS (Netherlands)

    Nijhof, A.H.J.; Jeurissen, R.J.M.

    2010-01-01

    Purpose – This paper aims to clarify that corporate social responsibility (CSR) has come a long way by the prevailing business case approach, but increasingly hits a glass ceiling. The glass ceiling metaphor refers to the inherent limitations created by a business case approach towards CSR. Design/m

  9. Communicating CSR and Business Identity in the Chemical Industry through Mission Slogans

    Science.gov (United States)

    Verboven, Hans

    2011-01-01

    This article analyzes the communication of corporate social responsibility (CSR) and corporate image in the chemical industry through mission slogans. Morsing's (2006) CSR communication framework is adapted for a comparative analysis of the strategies behind mission slogans. By grouping rhetorical strategies in a mission slogan into a mission…

  10. CSR Principal Perceptions of Support from the State Department of Education

    Science.gov (United States)

    Good, Thomas L.; McCaslin, Mary M.

    2005-01-01

    Elementary school principals who received a Comprehensive School Reform (CSR) award in January or August 2002 (n = 21) were invited to be interviewed in the late spring and summer of 2003. A total of 19 principals consented to audiotaped interviews. The interviews focused on several CSR dimensions, including principals' beliefs about the extent to…

  11. 17 CFR 249.331 - Form N-CSR, certified shareholder report.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Form N-CSR, certified shareholder report. 249.331 Section 249.331 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... Required Under Sections 13 and 15(d) of the Securities Exchange Act of 1934 § 249.331 Form N-CSR,...

  12. Which CSR-Related Headings Do "Fortune" 500 Companies Use on Their Websites?

    Science.gov (United States)

    Smith, Katherine Taken; Alexander, Julie J.

    2013-01-01

    This article examines website headings used by "Fortune" 500 companies in their efforts to inform stakeholders about corporate social responsibility (CSR). Instead of using "Corporate Social Responsibility" as a heading, companies often use specific terms to identify various CSR initiatives. The purpose of this article is to identify common…

  13. The Culture of Corporate Social Responsibility (CSR) in the Academic Framework: Some Literary Implications

    Science.gov (United States)

    Mehta, Sandhya Rao

    2011-01-01

    Corporate Social Responsibility (CSR) is swiftly emerging as an integral part of corporate culture and discourse. Associated with notions of responsibility, accountability and community involvement, it remains privileged with concerns that increasingly define the new millennium. Less developed, however, is the relevance of CSR ideas to academic…

  14. Program CSR Berbasis Pemberdayaan Masyarakat Menuju Kemandirian Ekonomi Pasca Tambang di Desa Sarij aya

    Directory of Open Access Journals (Sweden)

    Asa Ria Pranoto

    2016-09-01

    any indicator PT Pertamina EP is able to apply a good CSR refers to the MDGs documents, regulations regulations and ISO 26000. this study aimed to measure the effi ciency of the implementation as well as the response and participation in the implementation of CSR programs conducted.

  15. Won’t Get Fooled Again: The Effects of Internal and External CSR ECO-Labeling

    NARCIS (Netherlands)

    Gosselt, Jordy F.; Rompay, van Thomas; Haske, Laura

    2017-01-01

    Although most consumers are positive about socially responsible companies, in order to benefit from CSR efforts, effective and clear CSR communication is important. However, due to the constantly rising profusion of eco-labels, based on either own claims from the organization or claims made by an ex

  16. Phenethylisothiocyanate alters site- and promoter-specific histone tail modifications in cancer cells.

    Directory of Open Access Journals (Sweden)

    Yi Liu

    Full Text Available Site-specific histone modifications are important epigenetic regulators of gene expression. As deregulation of genes often results in complex disorders, corrective modulation of site-specific histone marks could be a powerful therapeutic or disease-preventive strategy. However, such modulation by dietary compounds and the resulting impact on disease risk remain relatively unexplored. Here we examined phenethylisothiocyanate (PEITC, a common dietary compound derived from cruciferous vegetables with known chemopreventive properties under experimental conditions, as a possible modulator of histone modifications in human colon cancer cells. The present study reports novel, dynamic, site-specific chemical changes to histone H3 in a gene-promoter-specific manner, associated with PEITC exposure in human colon tumor-derived SW480 epithelial cells. In addition, PEITC attenuated cell proliferation in a concentration- and time-dependent manner, likely mediated by caspase-dependent apoptotic signalling. The effects of PEITC on histone modifications and gene expression changes were achieved at low, non-cytotoxic concentrations, in contrast to the higher concentrations necessary to halt cancer cell proliferation. Increased understanding of specific epigenetic alterations by dietary compounds may provide improved chemopreventive strategies for reducing the healthcare burden of cancer and other human diseases.

  17. csrT Represents a New Class of csrA-Like Regulatory Genes Associated with Integrative Conjugative Elements of Legionella pneumophila

    OpenAIRE

    Abbott, Zachary D.; Flynn, Kaitlin J.; Byrne, Brenda G.; Mukherjee, Sampriti; Kearns, Daniel B.; Swanson, Michele S

    2016-01-01

    Bacterial evolution is accelerated by mobile genetic elements. To spread horizontally and to benefit the recipient bacteria, genes encoded on these elements must be properly regulated. Among the legionellae are multiple integrative conjugative elements (ICEs) that each encode a paralog of the broadly conserved regulator csrA. Using bioinformatic analyses, we deduced that specific csrA paralogs are coinherited with particular lineages of the type IV secretion system that mediates horizontal sp...

  18. 17 CFR 270.30a-2 - Certification of Form N-CSR and Form N-Q.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Certification of Form N-CSR... Form N-CSR and Form N-Q. (a) Each report filed on Form N-CSR (§§ 249.331 and 274.128 of this chapter... must include certifications in the form specified in Item 12(a)(2) of Form N-CSR or Item 3 of Form...

  19. The electrostatic Cryogenic Storage Ring CSR - Mechanical concept and realization

    Science.gov (United States)

    von Hahn, R.; Berg, F.; Blaum, K.; Crespo Lopez-Urrutia, J. R.; Fellenberger, F.; Froese, M.; Grieser, M.; Krantz, C.; Kühnel, K.-U.; Lange, M.; Menk, S.; Laux, F.; Orlov, D. A.; Repnow, R.; Schröter, C. D.; Shornikov, A.; Sieber, T.; Ullrich, J.; Wolf, A.; Rappaport, M.; Zajfman, D.

    2011-12-01

    A new and technologically challenging project, the electrostatic Cryogenic Storage Ring CSR, is presently under construction at the Max-Planck-Institute for Nuclear Physics in Heidelberg. Applying liquid helium cooling, the CSR, with 35 m circumference, will provide a low temperature environment of only a few Kelvin and an extremely high vacuum of better than 10 -13 mbar. To realize these conditions the mechanical design has been completed and now the first quarter section is in the construction phase. For the onion skin structure of the cryogenic system we have at the outer shell the cryostat chambers, realized by welded rectangular stainless steel frames with aluminum plates. The next two shells are fabricated as aluminum shields kept at 80 and 40 K. The inner vacuum chambers for the experimental vacuum consist of stainless steel chambers cladded with external copper sheets connected to the LHe lines for optimized thermal equilibration and cryopumping. Additional large surface 2 K units are installed for cryogenic pumping of H 2. The mechanical concepts and the realization will be presented in detail.

  20. I will do it if I enjoy it!: Seeking sensory pleasure when CSR campaigns offer participation

    Directory of Open Access Journals (Sweden)

    Rafaela eLardín-Zambudio

    2016-01-01

    Full Text Available In an attempt to gain differentiation, companies are allocating resources to corporate social responsibility (CSR initiatives. At the same time, they are giving consumers a more active role in the process of creating value. In this sense, consumer participation represents a new approach to gain competitive advantage. However, the effectiveness of consumer participation in CSR campaigns still remains unknown. With the purpose of shedding light on this issue, this paper shows that participatory CSR campaigns lead to greater consumer perceptions of CSR, which in turn results in more favorable attitudes toward the company. Furthermore, the effect is stronger for sensory pleasure seekers, whose involvement with the experience is greater. The findings contribute to the CSR literature and reveal important implications for marketers.

  1. Teaching Business Ethics to Critical Students—Adopting the Stance of Political CSR

    DEFF Research Database (Denmark)

    Toft, Kristian Høyer

    2015-01-01

    This paper provides ways of responding to critical students when teaching business ethics and corporate social responsibility (CSR). A common premise of teaching pedagogy is to approach students from their “zone of proximal development” (Vygotsky 1978). To get an understanding of students’ critical...... prior conceptions, the ideal type of the “liberal communist” (Žižek 2008) is invoked as suggestive of how students might think about business ethics and CSR. Two pedagogical approaches are suggested to address students’ a priori scepticism of business ethics and CSR. First, a framework of political...... views on CSR is presented. Second, approaching CSR by means of “problem based learning” is discussed. Finally, the paper reflects on the role of the business ethics teacher in light of tendencies towards commodification of education in the global economy....

  2. CSR BENCHMARKING IN THE ROMANIAN BUSINESS AND ACADEMIC SECTOR OF CLUJ-NAPOCA REGION

    Directory of Open Access Journals (Sweden)

    Alexandra GOGOZAN

    2012-01-01

    Full Text Available The challenge of the present article was to create an index or otherwise a database of CSR contributions that can be quantified and which should clarify the position of a company on the ladder of CSR, and also would enhance the comparability of efforts undertaken by socially responsible companies an institutions. 22 CSR aspects were taken into consideration concerning the interests of the banking sector, the commercial and academic sector, from Cluj-Napoca region, Romania. The benchmarking analysis took into consideration CSR aspects such as economical, environmental and social sustainability, the three pillars of sustainable development. The CSR aspects referred to all the stakeholders involved in those three sectors: employees, suppliers, costumers, community, shareholders and competitors.

  3. When does corporate social responsibility pay off? the impact of the country-level institutionalization of CSR

    NARCIS (Netherlands)

    Xiao, Chengyong; Wang, Qian; van Donk, Dirk Pieter; van der Vaart, Taco

    2015-01-01

    The literature on corporate social responsibility (CSR) has not yet provided a univocal answer to an important question, i.e., when does corporate social responsibility pay off? Drawing up institutional theory, this study contributes to the CSR literature through exploring the CSR-CFP (corporate fin

  4. Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism

    Science.gov (United States)

    Medina-Carmona, Encarnación; Neira, Jose L.; Salido, Eduardo; Fuchs, Julian E.; Palomino-Morales, Rogelio; Timson, David J.; Pey, Angel L.

    2017-01-01

    Disease associated genetic variations often cause intracellular enzyme inactivation, dysregulation and instability. However, allosteric communication of mutational effects to distant functional sites leading to loss-of-function remains poorly understood. We characterize here interdomain site-to-site communication by which a common cancer-associated single nucleotide polymorphism (c.C609T/p.P187S) reduces the activity and stability in vivo of NAD(P)H:quinone oxidoreductase 1 (NQO1). NQO1 is a FAD-dependent, two-domain multifunctional stress protein acting as a Phase II enzyme, activating cancer pro-drugs and stabilizing p53 and p73α oncosuppressors. We show that p.P187S causes structural and dynamic changes communicated to functional sites far from the mutated site, affecting the FAD binding site located at the N-terminal domain (NTD) and accelerating proteasomal degradation through dynamic effects on the C-terminal domain (CTD). Structural protein:protein interaction studies reveal that the cancer-associated polymorphism does not abolish the interaction with p73α, indicating that oncosuppressor destabilization largely mirrors the low intracellular stability of p.P187S. In conclusion, we show how a single disease associated amino acid change may allosterically perturb several functional sites in an oligomeric and multidomain protein. These results have important implications for the understanding of loss-of-function genetic diseases and the identification of novel structural hot spots as targets for pharmacological intervention. PMID:28291250

  5. American Institute for Cancer Research

    Science.gov (United States)

    ... About Cancer By Cancer Site What Is Cancer Foods That Fight Cancer Tools You Can Use Cancer Infographics & Multimedia Studying ... About Cancer By Cancer Site What Is Cancer Foods That Fight Cancer Tools You Can Use Cancer Infographics & Multimedia Studying ...

  6. Stakeholders’ responses to CSR tradeoffs: When other-orientation and trust trump material self-interest

    Directory of Open Access Journals (Sweden)

    Flore eBridoux

    2016-01-01

    Full Text Available When investing in corporate social responsibility (CSR, managers may strive for a win-win scenario where all stakeholders end up better off, but they may not always be able to avoid trading off stakeholders’ interests. To provide guidance to managers who have to make tradeoffs, this study used a vignette-based experiment to explore stakeholders’ intention to associate with a firm (i.e., buy from or become an employee that trades off CSR directed at the stakeholders’ own group (self-directed CSR and CSR directed at another stakeholder group (other-directed CSR. Results show that stakeholders were not systematically more attracted to a firm that favors their own group over another stakeholder group. Specifically, stakeholders’ other-orientation moderated their reaction to tradeoffs: stakeholders higher on other-orientation were willing to forego some material benefits to associate with a firm that treated suppliers in developing countries significantly better than its competitors, whereas stakeholders lower on other-orientation were more attracted to a firm favoring their own stakeholder group. Other-orientation also moderated reactions to tradeoffs involving the environment, although high CSR directed at the environment did not compensate for low self-directed CSR even for stakeholders higher on other-orientation. Second, the vignette study showed that trust mediated the relationship between tradeoffs and stakeholders’ reactions. The study contributes first and foremost to the burgeoning literature on CSR tradeoffs and to the multimotive approach to CSR, which claims that other motives can drive stakeholders’ reactions to CSR in addition to self-interest. First, it provides further evidence that studying CSR tradeoffs is important to understand both (prospective employees’ and customers’ reactions to CSR-related activities. Second, it identifies other-orientation as a motive-related individual difference that explains

  7. Stakeholders' Responses to CSR Tradeoffs: When Other-Orientation and Trust Trump Material Self-Interest.

    Science.gov (United States)

    Bridoux, Flore; Stofberg, Nicole; Den Hartog, Deanne

    2015-01-01

    When investing in corporate social responsibility (CSR), managers may strive for a win-win scenario where all stakeholders end up better off, but they may not always be able to avoid trading off stakeholders' interests. To provide guidance to managers who have to make tradeoffs, this study used a vignette-based experiment to explore stakeholders' intention to associate with a firm (i.e., buy from or become an employee) that trades off CSR directed at the stakeholders' own group (self-directed CSR) and CSR directed at another stakeholder group (other-directed CSR). Results show that stakeholders were not systematically more attracted to a firm that favors their own group over another stakeholder group. Specifically, stakeholders' other-orientation moderated their reaction to tradeoffs: stakeholders higher on other-orientation were willing to forego some material benefits to associate with a firm that treated suppliers in developing countries significantly better than its competitors, whereas stakeholders lower on other-orientation were more attracted to a firm favoring their own stakeholder group. Other-orientation also moderated reactions to tradeoffs involving the environment, although high CSR directed at the environment did not compensate for low self-directed CSR even for stakeholders higher on other-orientation. Second, the vignette study showed that trust mediated the relationship between tradeoffs and stakeholders' reactions. The study contributes first and foremost to the burgeoning literature on CSR tradeoffs and to the multimotive approach to CSR, which claims that other motives can drive stakeholders' reactions to CSR in addition to self-interest. First, it provides further evidence that studying CSR tradeoffs is important to understand both (prospective) employees' and customers' reactions to CSR-related activities. Second, it identifies other-orientation as a motive-related individual difference that explains heterogeneity in stakeholders' reactions to

  8. Transcriptional profile of fibroblasts obtained from the primary site, lymph node and bone marrow of breast cancer patients

    OpenAIRE

    2014-01-01

    Cancer-associated fibroblasts (CAF) influence tumor development at primary as well as in metastatic sites, but there have been no direct comparisons of the transcriptional profiles of stromal cells from different tumor sites. In this study, we used customized cDNA microarrays to compare the gene expression profile of stromal cells from primary tumor (CAF, n = 4), lymph node metastasis (N+, n = 3) and bone marrow (BM, n = 4) obtained from breast cancer patients. Biological validation was done ...

  9. Rare Sites of Metastases in Prostate Cancer Detected on Ga-68 PSMA PET/CT Scan—A Case Series

    Science.gov (United States)

    Dureja, Sugandha; Thakral, Parul; Pant, Vineet; Sen, Ishita

    2017-01-01

    Ga-68 labeled prostate-specific membrane antigen (PSMA) whole body PET/CT scan is a novel upcoming modality for the evaluation of prostate cancer. We present three cases of prostate cancer showing rare sites of metastases like brain, penis, and liver detected on Ga-68 PSMA PET/CT scan thus emphasizing its role in lesion detection and staging. PMID:28242977

  10. Analysis of risk factors of surgical site infections in breast cancer

    Institute of Scientific and Technical Information of China (English)

    GAO Yang-xu; XU Ling; YE Jing-ming; WANG Dong-min; ZHAO Jian-xin; ZHANG Lan-bo; DUAN Xue-ning; LIU Yin-hua

    2010-01-01

    Background Adjuvant chemotherapy has become an important component of standard therapy for breast cancer. However, until now, there have been few reports on the surgical site infections (SSI) after breast cancer surgery, specially after adjuvent chemotherapy. To study the risk factors of SSI of breast cancer, we analyzed patients diagnosed with breast cancer and treated with surgery. Methods Fifty-five patients diagnosed with breast cancer and received breast conserving or modified radical operations in our hospital during January 2008 to March 2008 were selected. Factors (patients' age, body mass index (BMI), diabetes mellitus, no or administered adjuvant chemotherapy, with or without onset of myelosuppression and the degree, surgical approaches, duration of operation, postoperative drainage duration and total drainage volume) associated with SSI were retrospectively reviewed and statistically analyzed by single factor analysis. Results Five patients suffered SSI (5/55, 9.1%); nineteen receiving adjuvant chemotherapy experienced Grade III+ myelosuppression, among which 4 had SSI; only 1 out of the remaining 36 patients without adjuvant chemotherapy had SSI. The difference between the two groups was significant (P=0.043). The incidence of SSI in patients with postoperative drainage tube indwelling longer than 10 days was 5/21, whereas no SSI occurred in that less than 10 days (R=0.009). in our study, there was no significient difference in other associated factors. Conclusions Concurrent Grade III+ myelosuppression after adjuvant chemotherapy is an important risk factor of SSI in breast cancer and needs further study. No SSI was detected with indwelling time of post operative drainage less than 10 days.

  11. Adopting and Implementing CSR Policies in Travel Agency Business: The Case of Romania

    Directory of Open Access Journals (Sweden)

    Ovidiu-Ioan Moisescu

    2015-12-01

    Full Text Available The paper investigates the extent to which Romania’s largest travel agencies adopt and implement corporate social responsibility (CSR policies, correlating these findings with their business performance reflected by their net turnover and net profit. In order to evaluate the level of CSR policies adoption and implementation, an online survey was conducted among top managers from each travel agency. The questionnaire comprised several sets of items reflecting workplace, environmental, marketplace, community, and, respectively, company values policies. Our results point to the fact that the CSR policies adopted and implemented to the highest degree are those concerning the marketplace, while the least embraced CSR policies refer to the environment. Our findings also suggest that there are several CSR policies which are adopted and implemented to a higher degree by larger travel agencies in terms of net turnover, while some other CSR policies are adopted more thoroughly by smaller ones. The results also indicate positive correlations between the profitability of travel agencies and the adoption and implementation of certain CSR policies. Last but not least, our research suggests that marketplace policies adoption and implementation could have a significant positive impact on business performance of travel agencies in terms of both net turnover and net profitability.

  12. Low Energy Electron Cooling and Accelerator Physics for the Heidelberg CSR

    Science.gov (United States)

    Fadil, H.; Grieser, M.; von Hahn, R.; Orlov, D.; Schwalm, D.; Wolf, A.; Zajfman, D.

    2006-03-01

    The Cryogenic Storage Ring (CSR) is currently under construction at MPI-K in Heidelberg. The CSR is an electrostatic ring with a total circumference of about 34 m, straight section length of 2.5 m and will store ions in the 20 ˜ 300 keV energy range (E/Q). The cryogenic system in the CSR is expected to cool the inner vacuum chamber down to 2 K. The CSR will be equipped with an electron cooler which has also to serve as an electron target for high resolution recombination experiments. In this paper we present the results of numerical investigations of the CSR lattice with finite element calculations of the deflection and focusing elements of the ring. We also present a layout of the CSR electron cooler which will have to operate in low energy mode to cool 20 keV protons in the CSR, as well as numerical estimations of the cooling times to be expected with this device.

  13. The Heidelberg CSR: Stored Ion Beams in a Cryogenic Environment

    Science.gov (United States)

    Wolf, A.; von Hahn, R.; Grieser, M.; Orlov, D. A.; Fadil, H.; Welsch, C. P.; Andrianarijaona, V.; Diehl, A.; Schröter, C. D.; Crespo López-Urrutia, J. R.; Rappaport, M.; Urbain, X.; Weber, T.; Mallinger, V.; Haberstroh, Ch.; Quack, H.; Schwalm, D.; Ullrich, J.; Zajfman, D.

    2006-03-01

    A cryogenic electrostatic ion storage ring CSR is under development at the Max-Planck Institute for Nuclear Physics in Heidelberg, Germany. Cooling of the ultrahigh vacuum chamber is envisaged to lead to extremely low pressures as demonstrated by cryogenic ion traps. The ring will apply electron cooling with electron beams of a few eV up to 200 eV. Through long storage times of 1000 s as well as through the low wall temperature, internal cooling of infrared-active molecular ions to their rotational ground state will be possible and their collisions with merged collinear beams of electrons and neutral atoms can be detected with high energy resolution. In addition storage of slow highly charged ions is foreseen. Using a fixed in-ring gas target and a reaction microscope, collisions of the stored ions at a spead of the order of the atomic unit can be kinematically reconstructed. The layout and the cryogenic concept are introduced.

  14. Multistage CSR microbunching gain development in transport or recirculation arcs

    CERN Document Server

    Tsai, Cheng-Ying; Li, Rui; Tennant, Chris

    2015-01-01

    Coherent synchrotron radiation (CSR) induced microbunching instability has been one of the most challenging issues in the design of modern accelerators. A linear Vlasov solver has been developed [1] and applied to investigate the physical processes of microbunching gain amplification for several example lattices [2]. In this paper, by further extending the concept of stage gain as proposed by Huang and Kim [3], we develop a method to characterize the microbunching development in terms of stage orders that allow the quantitative comparison of optics impacts on microbunching gain for different lattices. We find that the microbunching instability in our demonstrated arcs has a distinguishing feature of multistage amplification (e.g, up to 6th stage amplification for our example transport arcs, in contrast to two-stage amplification for a typical 4-dipole bunch compressor chicane). We also try to connect lattice optics pattern with the obtained stage gain functions by a physical interpretation. This Vlasov analys...

  15. Estimates of CSR Instability Thresholds for Various Storage Rings

    CERN Document Server

    Zimmermann, Frank

    2010-01-01

    We review the key predictions and conditions by several authors for the onset of longitudinal instabilities due to coherent synchrotron radiation (CSR), and evaluate them numerically for various storage rings, namely the KEKB High Energy Ring (HER) & Low Energy Ring (LER), SuperKEKB HER & LER, old and new designs of the SuperKEKB Damping Ring (DR), SuperB HER & LER, CLIC DR (2009 and 2010 design parameters), SLC DR, and ATF DR. We show that the theoretical uncertainty in the instability onset is at least at the level of 20-30% in bunch intensity. More importantly, we present some doubts about the general applicability for many of these storage rings of some commonly used formulae. To cast further light on these questions, an experiment at lower beam energy on the ATF Damping Ring is proposed.

  16. The RNA-binding protein CsrA plays a central role in positively regulating virulence factors in Erwinia amylovora

    Science.gov (United States)

    Ancona, Veronica; Lee, Jae Hoon; Zhao, Youfu

    2016-01-01

    The GacS/GacA two-component system (also called GrrS/GrrA) is a global regulatory system which is highly conserved among gamma-proteobacteria. This system positively regulates non-coding small regulatory RNA csrB, which in turn binds to the RNA-binding protein CsrA. However, how GacS/GacA-Csr system regulates virulence traits in E. amylovora remains unknown. Results from mutant characterization showed that the csrB mutant was hypermotile, produced higher amount of exopolysaccharide amylovoran, and had increased expression of type III secretion (T3SS) genes in vitro. In contrast, the csrA mutant exhibited complete opposite phenotypes, including non-motile, reduced amylovoran production and expression of T3SS genes. Furthermore, the csrA mutant did not induce hypersensitive response on tobacco or cause disease on immature pear fruits, indicating that CsrA is a positive regulator of virulence factors. These findings demonstrated that CsrA plays a critical role in E. amylovora virulence and suggested that negative regulation of virulence by GacS/GacA acts through csrB sRNA, which binds to CsrA and neutralizes its positive effect on T3SS gene expression, flagellar formation and amylovoran production. Future research will be focused on determining the molecular mechanism underlying the positive regulation of virulence traits by CsrA. PMID:27845410

  17. The RNA-binding protein CsrA plays a central role in positively regulating virulence factors in Erwinia amylovora.

    Science.gov (United States)

    Ancona, Veronica; Lee, Jae Hoon; Zhao, Youfu

    2016-11-15

    The GacS/GacA two-component system (also called GrrS/GrrA) is a global regulatory system which is highly conserved among gamma-proteobacteria. This system positively regulates non-coding small regulatory RNA csrB, which in turn binds to the RNA-binding protein CsrA. However, how GacS/GacA-Csr system regulates virulence traits in E. amylovora remains unknown. Results from mutant characterization showed that the csrB mutant was hypermotile, produced higher amount of exopolysaccharide amylovoran, and had increased expression of type III secretion (T3SS) genes in vitro. In contrast, the csrA mutant exhibited complete opposite phenotypes, including non-motile, reduced amylovoran production and expression of T3SS genes. Furthermore, the csrA mutant did not induce hypersensitive response on tobacco or cause disease on immature pear fruits, indicating that CsrA is a positive regulator of virulence factors. These findings demonstrated that CsrA plays a critical role in E. amylovora virulence and suggested that negative regulation of virulence by GacS/GacA acts through csrB sRNA, which binds to CsrA and neutralizes its positive effect on T3SS gene expression, flagellar formation and amylovoran production. Future research will be focused on determining the molecular mechanism underlying the positive regulation of virulence traits by CsrA.

  18. The Effect of Multiplicity of Metastatic Sites on Hormone Refractory Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Amal Halim

    2012-10-01

    Full Text Available Background: This study retrospectively evaluated the prognostic factors and treatment outcome of patients with hormone-refractory prostate cancer who received chemotherapy.Methods: We reviewed records of hormone-refractory prostate cancer patients who received chemotherapy between December 2004 and May 2011 at the Clinical Oncology and Nuclear Medicine Department, Mansoura University and the Oncology Outpatient Clinic of East Delta Insurance Institute, Egypt with regards to patient characteristics, response to chemotherapy, toxicity, survival and prognostic factors.Results: A total of 37 records were analyzed. Patients' median age was 66 years. The majority (70% had bone metastases. One patient received single agent prednisolone and 2 received single agent vinorelbine. There were 34 (92% who received a docetaxel based chemotherapy regimen for whom we determined the treatment outcome andprognostic factors. Patients underwent a median of six cycles of treatment (range: 4–11. Fourteen of 34 patients (%41 had ≥50% decrease in serum prostatic-surface antigen. Among 16 patients who had measurable disease at the baseline, 8 (50% achieved a partial response according to radiographic criteria. Of the 25 patients who experienced cancer pain before treatment initiation, 15 (60% reduced their analgesic drug intake. Grades 3-4 neutropenia occurred in 13 (38% patients. The median follow-up period was 13 months and the median event-free survival was 7 months (range: 4-31. The median overall survival period was 12 months (range: 4.5-37. According to multivariate regression analysis, multiplicity of metastatic sites was the only independent prognostic factor (P=0.005.Conclusions: Hormone-refractory prostate cancer is not considered totally resistant to chemotherapy. In this study, multiplicity of metastatic sites is the only independent prognostic factor. Survival figures are not satisfactory, therefore additional research is needed for achieving a better

  19. Sustainable Eco Coastal Development Through Corporate Social Responsibility (CSR) Program

    Science.gov (United States)

    Rakhmanissazly, Arsi; Mursito Ardy, Yong; Abdullah

    2017-02-01

    Besides technical problems the company’s operational constraints that may effect high deficiency for the company is the company – community conflicts. Company – community conflict can also arise depends on the geographic conditions and characteristics of the community itself. Some studies has show that coastal community have higher level of social risk when compared to non-coastal community. Also, the coastal community ussually only rely on what sea provides as their main livelihood. Because of the level of education still contemtible the community couldn’t optimized the potential of their own area. Corporate Social Responsibility (CSR) har emerged as an important approach for addressing the social and environmental impact of company activities. Through CSR program, PT Pertamina EP Asset 3 Tambun Field (PEP) try to form value integration by utilizing resources from the community and the company by making sustainable eco – coastal living in Desa Tambaksari, Karawang, one of PEP working area. Using sustainable livelihood approach begin with compiling data by doing social mapping PEP has initiate the area to becoming Fish Processing Industry Centre. By implementing PDCA in every steps of the program, PEP has multiplied some other programs such as Organic Fish Feed Processing, Seaweed Farming and Waste Bank for Green Coastal Village. These program is PEP’s effort to create a sustainability environment by enhancing the community’s potentials as well as resolving social problems around Tambaksari. The most important result besides getting our license to operate from the community, is the community itself can grow into an eco coastal sustainable system.

  20. A practical approach to implementing CSR in the electronics industry: global supply chain management focusing on corporate social responsibility

    Energy Technology Data Exchange (ETDEWEB)

    Jamieson, S.; Rice, G. [Panasonic Mobile Communication Development of Europe (PMCDE) (United Kingdom); Hilbron, R. [Vodafone Group Plc (United Kingdom); Clift, R.; Wehrmeyer, W. [Centre for Environmental Strategy, Univ. of Surrey (United Kingdom)

    2004-07-01

    This paper covers a co-operative investigation undertaken by Vodafone Plc and Panasonic Mobile Communications (PMC); applying Corporate Social Responsibility (CSR) principles in an actual assessment of the supply chain. Together, we carried out an informal CSR assessment on a Panasonic mobile phone handset manufacturing facility in the Philippines. CSR issues vary with geographical and cultural region. By researching CSR concerns typically encountered in the region, focal points of business performance for the Philippines investigation were identified. These are detailed in the paper. A key benefit from this assessment was the increased understanding of the management of the indirect CSR issues within the supply chain. This understanding is essential when developing a system for CSR supply-chain management. This paper will describe this exercise and its findings and will suggest future steps necessary to successfully integrate CSR principles though the global supply chain. (orig.)

  1. The Relationship Between CSR and Profitability to Firm Value in SRI-KEHATI Index

    Directory of Open Access Journals (Sweden)

    Widuri Kurniasari

    2015-03-01

    Full Text Available This study aims to investigate the relationship between Corporate Social Responsibility (CSR, Profitability to Firm Value. The samples are all manufacturer companies that listed in SRI-KEHATI Index by using control samples (manufacturers company not listed in SRI-KEHATI Index. This study is empirically examined between CSR disclosure (environment, energy, health and safety, product, and community services, profitability (ROA and firm value. For company that listed in Sri Kehati Index, this study found no significant relationship between CSR to firm value but there were positive significant relationship between profitability to firm value.

  2. Acute stress responses: A review and synthesis of ASD, ASR, and CSR.

    Science.gov (United States)

    Isserlin, Leanna; Zerach, Gadi; Solomon, Zahava

    2008-10-01

    Toward the development of a unifying diagnosis for acute stress responses this article attempts to find a place for combat stress reaction (CSR) within the spectrum of other defined acute stress responses. This article critically compares the diagnostic criteria of acute stress disorder (ASD), acute stress reaction (ASR), and CSR. Prospective studies concerning the predictive value of ASD, ASR, and CSR are reviewed. Questions, recommendations, and implications for clinical practice are raised concerning the completeness of the current acute stress response diagnoses, the heterogeneity of different stressors, the scope of expected outcomes, and the importance of decline in function as an indicator of future psychological, psychiatric, and somatic distress.

  3. Corporate Social Responsibility and Social Media Crises - How to ride off a CSR-related shitstorm

    DEFF Research Database (Denmark)

    Agerdal-Hjermind, Annette; Schmeltz, Line

    , and the case of the Norwegian chocolate brand Freia is used to illustrate how CSR-related issues are particularly vulnerable and thus potentially responsible for creating a social media crisis. The case furthermore serves to illustrate the importance of social media readiness, responsiveness and not least......This paper aims to explore and offer insights into the phenomenon of social media crises in a CSR-related context by reflexively merging theoretical and case insights (Alvesson & Kärreman, 2007, p. 2011). The phenomenon and the components of a social media crisis are theoretically identified...... strategy and communicative skills during a CSR-related social media crisis....

  4. Communicating Sustainability: Do Nordic Energy Corporations Exemplify a New Generation of CSR?

    DEFF Research Database (Denmark)

    Aggerholm, Helle Kryger; Trapp, Leila

    2011-01-01

    Heightened public interest in company efforts to address global issues, such as the climate issue, has influenced corporate social responsibility (CSR) and ethics programs (May, Cheney, & Roper, 2007). This interest has sparked a so-called “third generation” approach to CSR which involves extending...... of one company solving them alone, this shift has also inspired corporate collaboration with other companies, nonprofits, or governments (Austin, 2000). This paper aims at making an empirically based contribution to our understanding of this apparent contemporary evolution of CSR in the context...

  5. Cancer

    Science.gov (United States)

    ... cancer Non-Hodgkin lymphoma Ovarian cancer Pancreatic cancer Testicular cancer Thyroid cancer Uterine cancer Symptoms Symptoms of cancer ... tumor Obesity Pancreatic cancer Prostate cancer Stomach cancer Testicular cancer Throat or larynx cancer Thyroid cancer Patient Instructions ...

  6. Common fragile site profiling in epithelial and erythroid cells reveals that most recurrent cancer deletions lie in fragile sites hosting large genes.

    Science.gov (United States)

    Le Tallec, Benoît; Millot, Gaël Armel; Blin, Marion Esther; Brison, Olivier; Dutrillaux, Bernard; Debatisse, Michelle

    2013-08-15

    Cancer genomes exhibit numerous deletions, some of which inactivate tumor suppressor genes and/or correspond to unstable genomic regions, notably common fragile sites (CFSs). However, 70%-80% of recurrent deletions cataloged in tumors remain unexplained. Recent findings that CFS setting is cell-type dependent prompted us to reevaluate the contribution of CFS to cancer deletions. By combining extensive CFS molecular mapping and a comprehensive analysis of CFS features, we show that the pool of CFSs for all human cell types consists of chromosome regions with genes over 300 kb long, and different subsets of these loci are committed to fragility in different cell types. Interestingly, we find that transcription of large genes does not dictate CFS fragility. We further demonstrate that, like CFSs, cancer deletions are significantly enriched in genes over 300 kb long. We now provide evidence that over 50% of recurrent cancer deletions originate from CFSs associated with large genes.

  7. Physical activity in relation to all-site and lung cancer incidence and mortality in current and former smokers.

    Science.gov (United States)

    Alfano, Catherine M; Klesges, Robert C; Murray, David M; Bowen, Deborah J; McTiernan, Anne; Vander Weg, Mark W; Robinson, Leslie A; Cartmel, Brenda; Thornquist, Mark D; Barnett, Matt; Goodman, Gary E; Omenn, Gilbert S

    2004-12-01

    Increased physical activity has been associated with a reduction in the incidence and mortality from all-site cancer and some site-specific cancers in samples of primarily nonsmoking individuals; however, little is known about whether physical activity is associated with similar risk reductions among smokers and ex-smokers. This study examined physical activity in relation to all-site cancer and lung cancer incidence and mortality in a sample of current and former smokers (n = 7,045; 59% male; 95% Caucasian; mean age, 63 years) drawn from the beta-Carotene and Retinol Efficacy Trial, a lung cancer chemoprevention trial. Hazard rate ratios and 95% confidence intervals associated with a 1 SD increase in physical activity were 0.86 (0.80-0.94) for all-site cancer only among men, 0.84 (0.69-1.03) for lung cancer only for younger participants, 0.75 (0.59-0.94) for cancer mortality among younger participants and 0.68 (0.53-0.89) among women, and 0.69 (0.53-0.90) for lung cancer mortality only among women. These results suggest that incidence may be more attenuated by physical activity for men and mortality more attenuated for women. Effects may be more pronounced for younger people and may differ inconsistently by pack-years of smoking. Physical activity may play a role in reducing cancer risk and mortality among those with significant tobacco exposure. Prospective studies using more sophisticated measures of physical activity assessed at multiple time points during follow-up are needed to corroborate these associations.

  8. HPV genotyping and site of viral integration in cervical cancers in Indian women.

    Directory of Open Access Journals (Sweden)

    Poulami Das

    Full Text Available Persistent HPV infection plays a major role in cervical cancer. This study was undertaken to identify HPV types in a cohort of Indian women with locally advanced cervical cancer as well as to determine the physical state and/or site of viral integration in the host genome. Pretreatment biopsies (n = 270 from patients were screened for HPV infection by a high throughput HPV genotyping assay based on luminex xMAP technology as well as MY09/11 PCR and SPF1/2 PCR. Overall HPV positivity was observed to be 95%, with HPV16 being most common (63% followed by infection with HPV18. Integration status of the virus was identified using Amplification of Papillomavirus Oncogene Transcripts (APOT assay in a subset of samples positive for HPV16 and/or HPV18 (n = 86 and with an adequate follow-up. The data was correlated with clinical outcome of the patients. Integration of the viral genome was observed in 79% of the cases and a preference for integration into the chromosomal loci 1p, 3q, 6q, 11q, 13q and 20q was seen. Clinical data revealed that the physical state of the virus (integrated or episomal could be an important prognostic marker for cervical cancer.

  9. Tumor inoculation site affects the development of cancer cachexia and muscle wasting.

    Science.gov (United States)

    Matsuyama, Tatsuzo; Ishikawa, Takeshi; Okayama, Tetsuya; Oka, Kaname; Adachi, Satoko; Mizushima, Katsura; Kimura, Reiko; Okajima, Manabu; Sakai, Hiromi; Sakamoto, Naoyuki; Katada, Kazuhiro; Kamada, Kazuhiro; Uchiyama, Kazuhiko; Handa, Osamu; Takagi, Tomohisa; Kokura, Satoshi; Naito, Yuji; Itoh, Yoshito

    2015-12-01

    The phenotype and severity of cancer cachexia differ among tumor types and metastatic site in individual patients. In this study, we evaluated if differences in tumor microenvironment would affect the development of cancer cachexia in a murine model, and demonstrated that body weight, adipose tissue and gastrocnemius muscle decreased in tumor-bearing mice. Interestingly, a reduction in heart weight was observed in the intraperitoneal tumor group but not in the subcutaneous group. We evaluated 23 circulating cytokines and members of the TGF-β family, and found that levels of IL-6, TNF-α and activin A increased in both groups of tumor-bearing mice. Eotaxin and G-CSF levels in the intraperitoneal tumor group were higher than in the subcutaneous group. Atrogin 1 and MuRF1 mRNA expressions in the gastrocnemius muscle increased significantly in both groups of tumor-bearing mice, however, in the myocardium, expression of these mRNAs increased in the intraperitoneal group but not in subcutaneous group. Based on these results, we believe that differences in microenvironment where tumor cells develop can affect the progression and phenotype of cancer cachexia through alterations in various circulating factors derived from the tumor microenvironment.

  10. Leaders as Corporate Responsibility Spokesperson: How Leaders Explain Liabilites Via Corporate Web Sites?

    Directory of Open Access Journals (Sweden)

    Burcu Öksüz

    2014-12-01

    Full Text Available The aim of this paper is to reveal the corporate social responsibility (CSR understandings of corporations from the leaders’ perspective and discuss how leaders define and explain CSR practices their organizations executed as spokesperson via social media channels of their organizations.  In this context, a content analysis aiming to display the ideas of Turkey’s top 250 corporations’ leaders (CEO, chairman of the board, general manager designated by Istanbul Chamber of Industry in 2013. The leader messages about different dimensions of CSR and CSR practices that are partaking in corporate web sites were examined. According to the results of the analysis, it is found that the leaders act as responsible leaders, and also the spokesperson of their corporations. In addition it is found out that responsible leaders included multiplexed information on different dimensions and various practices of CSR in their social media messages.

  11. CORPORATE SOCIAL RESPONSIBILITY (CSR SEBAGAI INSTRUMEN HUKUM EKONOMI DI ERA GLOBALISASI

    Directory of Open Access Journals (Sweden)

    Nur Sulistyo B. Ambarini

    2010-09-01

    Full Text Available Globalization of the world have substantial influence the development of the state and the country of Indonesia. One of the globalization trends that influence the development of economic law in Indonesia is the Corporate Social Responsibility (CSR. Corporate Social Responsibility (CSR is a concept in economic activity associated with the embodiment of the concept of Sustainable Development . CSR arrangements in legislation, are a reflection of the principle of government intervention. In this regard CSR as an instrument of economic laws is mandatory to become a tool for corporate or business entity for achieve sustainable development and environmentally sound. This is intended as an effort to provide protection to the community, environment and natural resources of the business practices that harm. In addition it also guarantees the performance of firms in the economy in a balanced way to achieve socio-economic welfare of society.

  12. Antecedents and Consequences of Female Consumer Expectations and Evaluations toward CSR Activities

    Directory of Open Access Journals (Sweden)

    Bery Prima

    2012-06-01

    Full Text Available Many firms see Corporate Social Responsibility (CSR as necessary investments in the community where the firms operate in order to ensure and safeguard sustainable operation for the future. This paper investigates the causal relationship between the antecedents and consequences of consumer expectations and evaluation to CSR activities. The original contribution of this study is that it focuses on the perceptions of female consumers on CSR activities of a multinational company.The research employed 175 women in the Greater Jakarta region as respondents, which consists of 92 housewives and 83 career women. Respondents are existing customer of a multinational consumer goods firm operating in Indonesia. Analysis was performed using the Structural Equation Modeling. Final model showed that customer’s evaluation on the firms’ financial and ethical statements positively influences expectations and evaluations, while Consumer evaluation of a firms’ CSR has indirect effect on Consumer’s Trust, Loyalty and Perceived Risk.

  13. Global effects of the CSR-1 RNA interference pathway on the transcriptional landscape.

    Science.gov (United States)

    Cecere, Germano; Hoersch, Sebastian; O'Keeffe, Sean; Sachidanandam, Ravi; Grishok, Alla

    2014-04-01

    Argonaute proteins and their small RNA cofactors short interfering RNAs are known to inhibit gene expression at the transcriptional and post-transcriptional levels. In Caenorhabditis elegans, the Argonaute CSR-1 binds thousands of endogenous siRNAs (endo-siRNAs) that are antisense to germline transcripts. However, its role in gene expression regulation remains controversial. Here we used genome-wide profiling of nascent RNA transcripts and found that the CSR-1 RNA interference pathway promoted sense-oriented RNA polymerase II transcription. Moreover, a loss of CSR-1 function resulted in global increase in antisense transcription and ectopic transcription of silent chromatin domains, which led to reduced chromatin incorporation of centromere-specific histone H3. On the basis of these findings, we propose that the CSR-1 pathway helps maintain the directionality of active transcription, thereby propagating the distinction between transcriptionally active and silent genomic regions.

  14. DOES THE INSTITUTIONAL ENVIRONMENT AFFECT CSR DISCLOSURE? THE ROLE OF GOVERNANCE

    Directory of Open Access Journals (Sweden)

    María del Mar Miras Rodríguez

    2016-11-01

    Full Text Available The aim of this article is to analyze whether the institutional environment has a direct effect on Corporate Social Responsibility (CSR reporting practices or if this effect is explained by the influence of the institutional environment on Corporate Governance (CG mechanisms. To conduct our study, we focused on two countries that reflect different types of institutional environment: relation-based (Brazil and rule-based (Spain. Based on our results, we can affirm that the institutional environment influences CG mechanisms (Board Size and Reference Shareholder as well as companies’ CSR disclosure. Additionally, the CG mechanisms affected by the institutional environment also help to explain differences in CSR reporting practices. As relation-based societies evolve into rules-based environments, the information disclosed about CSR becomes more complex due to a strengthening of CG mechanisms.

  15. Are Australian Universities Making Good Use of ICT for CSR Reporting?

    Directory of Open Access Journals (Sweden)

    Raquel Garde Sánchez

    2015-11-01

    Full Text Available The higher education system in Australia has witnessed various government initiatives that have provided funding to integrate corporate social responsibility (CSR issues and thus contribute to the training of professionals with a strong sense of ethics, social values and concern for the repercussions of business activities in society. There are increasing demands from stakeholders for more transparent and more accountable information, including questions related to CSR. This paper analyses the policies and communication strategies regarding CSR information applied in Australian universities and considers whether they are making good use of information and communication technologies (ICT to facilitate interaction with stakeholders. The results show that ICT have not been considered a relevant tool in terms of improving accountability regarding CSR concerns in Australian universities, although they could represent a differentiation factor in the competitive environment of higher education.

  16. Prognostic factors and sites of metastasis in unresectable locally advanced pancreatic cancer.

    Science.gov (United States)

    Peixoto, Renata D'Alpino; Speers, Caroline; McGahan, Colleen E; Renouf, Daniel J; Schaeffer, David F; Kennecke, Hagen F

    2015-08-01

    Due to differences in natural history and therapy, clinical trials of patients with advanced pancreatic cancer have recently been subdivided into unresectable locally advanced pancreatic cancer (LAPC) and metastatic disease. We aimed to evaluate prognostic factors in LAPC patients who were treated with first-line chemotherapy and describe patterns of disease progression. Patients with LAPC who initiated first-line palliative chemotherapy, 2001-2011 at the BC Cancer Agency were included. A retrospective chart review was conducted to identify clinicopathologic variables, treatment, and subsequent sites of metastasis. Kaplan-Meier and Cox-regression survival analyses were performed. A total of 244 patients were included in this study. For the majority of patients (94.3%), first-line therapy was single-agent gemcitabine. About 144 (59%) patients developed distant metastatic disease and the most frequent metastatic sites included peritoneum/omentum (42.3%), liver (41%), lungs (13.9%), and distant lymph nodes (9%). Median overall survival (OS) for the entire cohort was 11.7 months (95% CI, 10.6-12.8). Development of distant metastases was associated with significantly inferior survival (HR 3.56, 95% CI 2.57-4.93), as was ECOG 2/3 versus 0/1 (HR 1.69, 95% CI 1.28-2.23), CA 19.9 > 1000 versus ≤ 1000 (HR 1.59, 95% CI 1.19-2.14) and female gender, (HR 1.57, 95% CI 1.19-2.08). In this population-based study, 41% of LAPC patients treated with first-line chemotherapy died without evidence of distant metastases. Prognostic factors for LAPC were baseline performance status, elevated CA 19.9, gender, and development of distant metastasis. Results highlight the heterogeneity of LAPC and the importance of locoregional tumor control.

  17. Focus on a New Approach in College Reading Instruction-Collaborative Strategic Reading (CSR)

    Institute of Scientific and Technical Information of China (English)

    孙松

    2012-01-01

      As an attempt to seek more reliable and valid methodology to enhance traditional college reading classes in China, the paper aims to explore an instructional approach named Collaborative Strategic Reading (CSR) based on the analysis of current college reading instructions, the suitability of CSR applied in authentic teaching context as well as pedagogical recommendations attempted to present practicable concept for college reading instructions.

  18. CSR as a Marketing Tool : a Case Study of Fast Food Restaurant in Malaysia

    OpenAIRE

    Abdul Razak, Armiza

    2014-01-01

    The use of corporate social responsibility (CSR) as being an efficient marketing tool would be matter that is being researched, especially with the increasing awareness of consumers about the importance of commercial organizations doing business in ways that do not harm the consumers or the environment. The aim of the research will be to obtain data from qualitative data in order to determine whether using CSR as being a marketing tool would bring a higher level of efficiency in the marketing...

  19. Anti-korruption i Mærsk - Et kommunikationsprojekt om CSR

    OpenAIRE

    Nielsen, Uffe Dalskov; Andersen, Kamilla Haugaard; Gaard, Sidsel Kristine; Madsen, Maria Chas; Merrild, Martin; Bak, Nina Ringgård

    2016-01-01

    This project examines how Mærsk communicates the company’s efforts on anti- corruption, and how far external demands and expectations affect Mærsk’s communication on CSR and anti-corruption initiatives. The study is based on a theoretical framework of critical discourse analysis, theories for the analysis of social practises, as well as theory on CSR. Based on social constructivism, Mærsk’s annual sustainability reports, published between 2009 and 2014, are analysed. This analysis is supporte...

  20. What do consumers "like"? Communicating CSR to consumers in Facebook, views from the airline industry

    OpenAIRE

    Tani, Essi

    2012-01-01

    Abstract AALTO UNIVERSITY SCHOOL OF BUSINESS ABSTRACT International Business Communication Master's Thesis June 2012 Essi Tuulia Tani What do consumers like? Communicating CSR to consumers in Facebook, views from the airline industry Objective of the Study The main objective of the study was to investigate airlines' CSR related communication to consumers through Facebook. More specifically the study focused on (a) Finland's largest airline's, Finnair's, perspective to...

  1. PENGARUH CORPORATE SOCIAL ESPONSIBILITY (CSR) TERHADAP CITRA PERUSAHAAN PADA PT TELEKOMUNIKASI INDONESIA, TBK AREA MAKASSAR

    OpenAIRE

    ERWIN, MUHAMMAD

    2012-01-01

    Muhammad Erwin, INFLUENCE OF CORPORATE SOCIAL RESPONSIBILITY TO CORPORATE IMAGE IN PT. TELEKOMUNIKASI INDONESIA, TBK AREA MAKASSAR (mentored by Dr. Idayanti, SE.,M.Siand Abdullah Sanusi, SE., MBA). This research aims to determine the influence either together or partially between CSR (Corporate Social Responsibility) to corporate image in PT. Telekomunikasi Indonesia, TbkMakassar area, that being measured from CSR variables which is Profit, People, and Planet. Expectedly the information o...

  2. Analýza vlivu CSR na pracovní spokojenost zaměstnanců

    OpenAIRE

    Krasnikova, Darina

    2010-01-01

    In now days knowledge society employees become the most important recourse of all kind of commercial and non-profit organizations. Employers are making efforts to create the best possible conditions with goal to get and hold the best employees. One of the complex tools to make those work conditions better and increase the satisfaction of the employees is concept of Corporate Social Responsibility (CSR). CSR is a policy for management of the organization which builds base for a sustainable dev...

  3. Embedding corporate social responsibility (CSR) with firm entrepreneurship : a contested exploration to advance corporate social entrepreneurship.

    OpenAIRE

    M. M. Uddin; Hughes, M.; Burrows, P.

    2016-01-01

    Corporate social responsibility (CSR) and entrepreneurship of firm both are widely researched scholarly domains. CSR is simultaneously a contested yet widely accepted concept in the academic and practitioner world. Creating shared value embedding social and business objectives together is more or less explored and adopted by the firms and known to the world. However, going beyond embedding social and business objectives for greater value creation is something which has not well...

  4. Peran Public Relations melalui Kegiatan Corporate Social Responsibility (CSR Islami Berbasis Pemberdayaan Masyarakat

    Directory of Open Access Journals (Sweden)

    Prima Ayu Rizqi Mahanani

    2015-12-01

    Full Text Available Image (good image is a valuable asset to a company for participating into the carrying capacity in the face of increasingly fierce competition in this era of globalization. So it becomes a moral obligation and operations to build a good image of the company that is one of the Corporate Social Responsibility (CSR. This requires a strategic role of public relations in order to carry out CSR activities are on target and provide the benefit that aims to empower the community or the community at large. The strategic role of public relations is expected to be a strategic tool for management to achieve its goals. This paper attempts to analyze the descriptive CSR activities that have been carried out by two national companies / multinational in Indonesia and one government-owned enterprises are not just mere charity but aims to empower the people of Indonesia. With the intention of reviewing the CSR program that truly provide benefit to the independence of program beneficiaries, not become dependent, and not merely interpreted deeds alone company. So that later people perceive right to CSR which is a form of actualization of corporate responsibility and communication between the company and the public. Among prorgam CSR conducted by Telkomsel, Sinar Mas, and the Bank by making strategic empowerment activities with a primary focus on education and training, sports, health, agriculture, infrastructure, social, cultural, environmental maintenance, local business development, partnerships and small businesses. All the CSR program aimed at the development of human resources and better adapted to the real needs (real need community. Keywords: Public Relations, CSR, Empowerment

  5. Measurement of CSR Performance of the Corporate Located in Talegaon Industrial Belt, Pune, India

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    Yukiko Hashimoto

    2014-05-01

    Full Text Available Being socially responsible is now a business obligation for by corporate entities. Today, about 90% of leading companies in India are involved in various CSR programmes such as working for education, health, empowerment of women and environment. Recently, CSR has evolved from philanthropy to a business related phenomenon because the new CSR concept with gaining some strategic advantage and sustainability has been widely recognized. This article examines whether corporates in India (including multinationals operating business in India are practicing strategic CSR based on the survey conducted in Talegaon Maharashtra Industrial Development Council (MIDC in Pune, India. Also, we try to measure the community impact socially and economically. The result shows that the most of the companies in Talegaon still practice a philanthropic approach but they have made improvement on community impact from 2011 to 2013. After the action research and intervention, some companies started a developmental and strategic approach for their community. It can be concluded that the quantity and area of CSR have been increased according to the community needs and community participation is very important to conduct CSR.

  6. Social Performance vs. Financial Performance: CSR Disclosures as an indicator of social performance

    Directory of Open Access Journals (Sweden)

    İlker Yılmaz

    2013-04-01

    Full Text Available In recent decades, it is gaining more and more dominance in both academic and business life that the company exists for and has responsibilities toward a wider group of stakeholders and it must have some objectives other than profitability. To achieve sustainable development and growth, the companies must assume more duties, which is called the term “corporate social responsibility (CSR.” In the literature, it is questioned whether CSR activities benefit the company or not; whether there is any relationship exists between CSR activities and the company’s financial performance and the direction of the relationship. We aimed to explore that whether there is any effect corporate social performance (CSP on financial performance and position and vice versa. We performed content analysis through annual reports and derived a social score composed of the items included in disclosure guidelines and some criteria used in CSR ratings. We also used several financial position and financial performance indicators. In order to explore the relationship between CSP and financial indicators, we run panel data regressions. We found significant results for some of the indicators, where some of the indicators gave insignificant results. The reporting of CSR activities is in very low levels. The conscious toward CSR and sustainability must be promoted and the companies must assume more active roles. The reporting of those activities is also important.

  7. Complex regulatory network encompassing the Csr, c-di-GMP and motility systems of Salmonella Typhimurium.

    Science.gov (United States)

    Jonas, Kristina; Edwards, Adrianne N; Ahmad, Irfan; Romeo, Tony; Römling, Ute; Melefors, Ojar

    2010-02-01

    Bacterial survival depends on the ability to switch between sessile and motile lifestyles in response to changing environmental conditions. In many species, this switch is governed by (3'-5')-cyclic-diguanosine monophosphate (c-di-GMP), a signalling molecule, which is metabolized by proteins containing GGDEF and/or EAL domains. Salmonella Typhimurium contains 20 such proteins. Here, we show that the RNA-binding protein CsrA regulates the expression of eight genes encoding GGDEF, GGDEF-EAL and EAL domain proteins. CsrA bound directly to the mRNA leaders of five of these genes, suggesting that it may regulate these genes post-transcriptionally. The c-di-GMP-specific phosphodiesterase STM3611, which reciprocally controls flagella function and production of biofilm matrix components, was regulated by CsrA binding to the mRNA, but was also indirectly regulated by CsrA through the FlhDC/FliA flagella cascade and STM1344. STM1344 is an unconventional (c-di-GMP-inactive) EAL domain protein, recently identified as a negative regulator of flagella gene expression. Here, we demonstrate that CsrA directly downregulates expression of STM1344, which in turn regulates STM3611 through fliA and thus reciprocally controls motility and biofilm factors. Altogether, our data reveal that the concerted and complex regulation of several genes encoding GGDEF/EAL domain proteins allows CsrA to control the motility-sessility switch in S. Typhimurium at multiple levels.

  8. Effects of Cryogenic Temperature on Fracture Toughness of Core-Shell Rubber (CSR) Toughened Epoxy Nanocomposites

    Science.gov (United States)

    Wang, J.; Cannon, S. A.; Magee, D.; Schneider, J. A.

    2008-01-01

    This study investigated the effects of core-shell rubber (CSR) nanoparticles on the mechanical properties and fracture toughness of an epoxy resin at ambient and liquid nitrogen (LN2) temperatures. Varying amounts of Kane Ace MX130 toughening agent were added to a commercially available EPON 862/Epikure W epoxy resin. Elastic modulus was calculated using quasi-static tensile data. Fracture toughness was evaluated by the resulting breaking energy measured in Charpy impact tests conducted on an instrumented drop tower. The size and distribution of the CSR nanoparticles were characterized using Transmission Electron Microscopy (TEM) and Small Angle X-ray Scattering (SAXS). Scanning Electron Microscopy (SEM) was used to study the fracture surface morphology. The addition of the CSR nanoparticles increased the breaking energy with negligible change in elastic modulus and ultimate tensile stress (UTS). At ambient temperature the breaking energy increased with increasing additions of the CSR nanoparticles, while at LN2 temperatures, it reached a maximum at 5 wt% CSR concentration. KEY WORDS: liquid nitrogen (LN2) properties, fracture toughness, core-shell rubber (CSR).

  9. Do CSR Practices Of Banks In Mauritius Lead To Satisfaction And Loyalty?

    Directory of Open Access Journals (Sweden)

    Ramlugun Vidisha Gunesh

    2015-08-01

    Full Text Available This study aims to determine how CSR activities of banks in Mauritius impact on customers’ satisfaction and loyalty towards banks. A stakeholder approach to CSR and Carroll’s (1991 four part definition was adopted, which included economic, legal, ethical and philanthropic corporate social responsibilities. A three- section questionnaire was used for data collection. 384 questionnaires were distributed, out of which 352 were returned. The results indicate that philanthropic CSR, economic CSR and ethical CSR, in their order of descending importance, are significant predictors of customer satisfaction and loyalty. The study shows that legal responsibilities however did not influence customer satisfaction and loyalty. The study concludes that philanthropic, economic and ethical CSR could be areas to further investigate with a view to benefit from competitive advantage in the banking sector. The study purports to contribute to existing literature by providing evidence that Carroll’s model may not be applicable in non-western context, more particularly so, in small economies. The study also advocates future research avenues.

  10. Pathological Predictors for Site of Local Recurrence After Radiotherapy for Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Chopra, Supriya [Department of Radiation Oncology, University of Toronto, Toronto (Canada); Princess Margaret Hospital, University Health Network, Toronto (Canada); Toi, Ants [Princess Margaret Hospital, University Health Network, Toronto (Canada); Department of Medical Imaging, University of Toronto, Toronto (Canada); Taback, Nathan [Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto (Canada); Evans, Andrew [Princess Margaret Hospital, University Health Network, Toronto (Canada); Department of Pathology, University of Toronto, Toronto (Canada); Haider, Masoom A. [Princess Margaret Hospital, University Health Network, Toronto (Canada); Department of Medical Imaging, University of Toronto, Toronto (Canada); Sunnybrook Health Sciences Center, Toronto (Canada); Milosevic, Michael; Bristow, Robert G.; Chung, Peter; Bayley, Andrew [Department of Radiation Oncology, University of Toronto, Toronto (Canada); Princess Margaret Hospital, University Health Network, Toronto (Canada); Morton, Gerard; Vesprini, Danny [Department of Radiation Oncology, University of Toronto, Toronto (Canada); Odette Cancer Center, Sunnybrook Health Sciences Center, Toronto (Canada); Warde, Padraig; Catton, Charles [Department of Radiation Oncology, University of Toronto, Toronto (Canada); Princess Margaret Hospital, University Health Network, Toronto (Canada); Menard, Cynthia, E-mail: Cynthia.Menard@rmp.uhn.on.ca [Department of Radiation Oncology, University of Toronto, Toronto (Canada); Princess Margaret Hospital, University Health Network, Toronto (Canada)

    2012-03-01

    Purpose: Rational design of targeted radiotherapy (RT) in prostate cancer (Pca) hinges on a better understanding of spatial patterns of recurrence. We sought to identify pathological factors predictive for site of local recurrence (LR) after external beam RT. Methods and Materials: Prospective databases were reviewed to identify men with LR after RT from 1997 through 2009. Patients with biochemical failure and biopsy-confirmed Pca more than 2 years after RT were evaluated. Prediction for site of recurrence based on the following pretreatment factors was determined on independent and cluster-sextant basis: presence of malignancy, dominant vs. nondominant percentage core length (PCL) involvement, PCL {>=} or <40%, and Gleason score. Sites of dominant PCL were defined as sextants with peak PCL involvement minus 10%, and >5% for each patient. Results: Forty-one patients with low-intermediate risk Pca constituted the study cohort. Median time to biopsy after RT was 51 months (range, 24-145). Of 246 sextants, 74 were involved with tumor at baseline. When sextants are treated as independent observations the presence of malignancy (77% vs. 22%, p = 0.0001), dominant PCL (90% vs. 46%, p = 0.0001), and PCL {>=}40% (89% vs. 68 %, p = 0.04) were found to be significant predictors for LR, although PCL {>=}40% did not retain statistical significance if sextants were considered correlated. The vast majority of patients (95%) recurred at the original site of dominant PCL or PCL {>=}40%, and 44% also recurred in regions of nondominant PCL <40% (n = 8) and/or benign sampling (n = 14) at baseline. Conclusions: LR after RT predominantly occurs in regions bearing higher histological tumor burden but are not isolated to these sites. Our data highlights the value of spatially resolved baseline pathological sampling and may assist in the design of clinical trials tailoring RT dose prescriptions to subregions of the prostate gland.

  11. THE IMPORTANCE OF ENVIRONMENTAL PROTECTION IN CSR POLICY

    Directory of Open Access Journals (Sweden)

    Rosca Mihai Ioan

    2011-12-01

    Full Text Available The CSR policy of companies occupy a privileged environment through coaching programs to other interests such as employees, suppliers, customers, authorities and various NGOs. This is why we wanted to see what the environment is important for managers on companies in Romania, the company's CSR policy. In the literature the definition of social responsibility and ways to implement this in practice are often encountered. Some authors claim that societal marketing concept has not found its way into the language of business. From here, there were other terms that had a greater impact on the business environment such as social responsibility. Increasing the company's impact on the environment, the pressure exerted by stakeholders, and identifying positive elements of socially responsible approach have been the main stimulus for development of social responsibility. From that a lot of studies on academic and commercial problem. And the present study fit the same line we conducted a research on 50 companies,it was an exploratory research. As respondents were chosen only marketing managers or general managers or even owners compnaie depending, in other words I tried to go directly to company decision makers in developing and building its image. While this one sample is statistically representative of the point of view we have covered with him in all areas of business activities and of all sizes can say that the results provide a clear enough picture of managersmentality in companies in Romania on business activities with the problem of intereactiunii environment Managers of companies in Romania recognize the environmental problems and say they are implicating in various actions to protect the environment. On the declarative level social environment is one of the most important areas being the most nominated as one of the top three areas of social nature that would involve having the greatest opportunity for development in coming years, over 60% of

  12. Isolated colostomy site recurrence in rectal cancer-two cases with review of literature

    Directory of Open Access Journals (Sweden)

    Singhal Vinay

    2007-05-01

    Full Text Available Abstract Background Colostomy site carcinomas are rare with only eight cases reported in the world literature. Various etiological factors like adenoma-cancer sequence, bile acids, recurrent and persistent physical damage at the colostomy site by faecal matter due to associated stomal stenosis have been considered responsible. Two such cases are being reported and in both cases there was no evidence of any local recurrence in the pelvis or liver and distant metastasis. Both patients had received adjuvant chemotherapy following surgery. Case presentation First case was a 30-year-old male that had reported with large bowel obstruction due to an obstructing ulcero-proliferative growth (poorly differentiated adenocarcinoma at the colostomy site after abdomino-perineal resection, performed for low rectal cancer six years previously. Wide local excision with microscopically free margins was performed with a satisfactory outcome. Four years later he presented with massive malignant ascites, cachexia and multiple liver metastasis and succumbed to his disease. Second case was a 47-year-old male that presented with acute large bowel obstruction due to an annular growth (well differentiated adenocarcinoma in the upper rectum. He was managed by Hartmann's operation and the sigmoid colostomy was closed six months later. Five years following closure of colostomy, he presented with two parietal masses at the previous colostomy site scar, which, on fine needle aspiration cytology were found to be well-differentiated adenocarcinomas of colorectal type. Surgery in the form of wide local resection with free margins was performed. He presented again after five years with recurrence along the previous surgery scar and an incisional hernia and was managed by wide local excision along with hernioplasty. Follow-up of nine years following first surgery is satisfactory. Conclusion Colostomy site/scar recurrence of rectal carcinoma is rare and could be due to various

  13. Stakeholder Models for Social and Mobile Media CSR Projects

    DEFF Research Database (Denmark)

    Kampf, Constance Elizabeth

    2014-01-01

    This paper is intended to demonstrate current uses of smartphone and social media technology by consumers. The three cases discussed show ways in which consumers have built communities through social and mobile media for a range of purposes—1) to organize their purchasing activities to get busine...... and mobile media to address strategy issues with businesses. Thus, these cases reveal a technology-enabled blurring of the boundaries between companies and their stakeholders through consumers' actions.......This paper is intended to demonstrate current uses of smartphone and social media technology by consumers. The three cases discussed show ways in which consumers have built communities through social and mobile media for a range of purposes—1) to organize their purchasing activities to get...... have built up an increasingly global presence since their founding in 2007-2008. Given the longevity of these organizations, which are still operating in 2012, their versions of CSR, and the internet presences they have built up, these cases demonstrate examples of consumers mobilizing through social...

  14. High-resolution CSR GRACE RL05 mascons

    Science.gov (United States)

    Save, Himanshu; Bettadpur, Srinivas; Tapley, Byron D.

    2016-10-01

    The determination of the gravity model for the Gravity Recovery and Climate Experiment (GRACE) is susceptible to modeling errors, measurement noise, and observability issues. The ill-posed GRACE estimation problem causes the unconstrained GRACE RL05 solutions to have north-south stripes. We discuss the development of global equal area mascon solutions to improve the GRACE gravity information for the study of Earth surface processes. These regularized mascon solutions are developed with a 1° resolution using Tikhonov regularization in a geodesic grid domain. These solutions are derived from GRACE information only, and no external model or data is used to inform the constraints. The regularization matrix is time variable and will not bias or attenuate future regional signals to some past statistics from GRACE or other models. The resulting Center for Space Research (CSR) mascon solutions have no stripe errors and capture all the signals observed by GRACE within the measurement noise level. The solutions are not tailored for specific applications and are global in nature. This study discusses the solution approach and compares the resulting solutions with postprocessed results from the RL05 spherical harmonic solutions and other global mascon solutions for studies of Arctic ice sheet processes, ocean bottom pressure variation, and land surface total water storage change. This suite of comparisons leads to the conclusion that the mascon solutions presented here are an enhanced representation of the RL05 GRACE solutions and provide accurate surface-based gridded information that can be used without further processing.

  15. A microRNA-7 binding site polymorphism in HOXB5 leads to differential gene expression in bladder cancer.

    Directory of Open Access Journals (Sweden)

    Junhua Luo

    Full Text Available PURPOSE: To investigate the biological function of HOXB5 in human bladder cancer and explore whether the HOXB5 3'-UTR SNP (1010A/G, which is located within the microRNA-7 binding site, was correlated with clinical features of bladder cancer. METHODS: Expression of HOXB5 in 35 human bladder cancer tissues and 8 cell lines were examined using real-time PCR and immunohistochemistry. Next, we explored the biological function of HOXB5 in vitro using cell proliferation, migration and colony formation assays. Using bioinformatics, a SNP (1010A/G was found located within the microRNA-7 binding site in the 3'-UTR of HOXB5. Real-time PCR was used to test HOXB5 expression affected by different alleles. Finally, multivariate logistic regression analysis was used to determine the relationship between SNP (1010A/G frequency and clinical features in 391 cases. RESULTS: HOXB5 was frequently over-expressed both in bladder cancer tissues and cell lines. Inhibition of HOXB5 suppressed the oncogenic function of cancer cells. Next, we demonstrated that a SNP (1010A/G, located within the microRNA-7 binding site in the 3'-UTR of HOXB5, could affect HOXB5 expression in bladder cancer mainly by differential binding activity of microRNA-7 and SNP-related mRNA stability. Finally, we also showed the frequency of 1010G genotype was higher in cancer group compared to normal controls and correlated with the risk of high grade and high stage. CONCLUSION: HOXB5 is overexpressed in bladder cancer. A miRNA-binding SNP (1010A/G located within 3'-UTR of HOXB5 is associated with gene expression and may be a promising prognostic factor for bladder cancer.

  16. Exploring ISO 26000 and Global Reporting Initiatives (GRI: a neo-institutional analysis of two CSR institutions

    Directory of Open Access Journals (Sweden)

    Reevany Bustami

    2013-01-01

    Full Text Available In the last decade or so, organizations have witnessed corporate social responsibility (CSR increasingly becoming part of the mainstream business practice and expectation. CSR has, in many ways been institutionalized as a standard practice for mainly large companies, especially MNCs. At various levels, ranging from individual company level to international level, a wide range of institutional arrangements and structures of CSR have been established, maintained and diffused in order to provide “a logic of appropriateness” and “give the expression and direction” (Campbell, 2006, p. 926 of CSR. However, in the context of institutionalization, these institutional arrangements of CSR have not been examined systematically. In particular, little attention has been given to the comparative analysis of two leading institutions of CSR: ISO 26000 and Global Reporting Initiatives (GRI. Adopting an analytical framework based on neo-institutional theory, this article explores and analyses both GRI and ISO 26000.

  17. Trends in head and neck cancer incidence in Denmark, 1978-2007: Focus on human papillomavirus associated sites

    DEFF Research Database (Denmark)

    Blomberg, Maria; Nielsen, Ann; Plum, Christian Edinger Munk;

    2011-01-01

    and the overall incidence increased throughout the period. Significantly increasing incidence rates were notably seen for tumors in the oral cavity (2.2% per year), tonsils (4.8% per year), oropharynx (3.5% per year) and hypopharynx (4.4% per year). A significantly decreasing incidence of lip cancer was observed...... among men (-5.0% per year). Cancers at HPV-associated sites (n = 3650) showed strongly increasing incidence rates, primarily in individuals years. In contrast, HNCs at sites not related to HPV infection showed a significant decrease (in men) or virtually no change in incidence (in women). Our...

  18. Evaluation the susceptibility of five polymorphisms in microRNA-binding sites to female breast cancer risk in Chinese population.

    Science.gov (United States)

    He, Bang-Shun; Pan, Yu-Qin; Lin, Kang; Ying, Hou-Qun; Wang, Feng; Deng, Qi-Wen; Sun, Hui-Ling; Gao, Tian-Yi; Wang, Shu-Kui

    2015-11-15

    Polymorphisms in microRNA (miRNA) binding site have been widely discussed to be associated with cancer risk; however, the associations were unclear in Chinese population. To investigate the associations of five polymorphisms (rs11097457, rs1434536, rs1970801, rs1044129, rs11169571) in miRNA binding sites with breast cancer risk, a total of 435 female patients with breast cancer and 439 age- and gender-matched tumor-free individuals were enrolled in this case-control study. Sequenom MassARRAY was applied to detect the polymorphisms, and the immunohistochemistry assay was used to measure the expression of estrogen receptor (ER) and progesterone receptor (PR) and CerbB-2. The data showed that these polymorphisms were not associated with breast cancer risk or clinical characters of breast cancer in all participants and sub-group with the exception that, in the sub-group of women with their first menstruation after 14 years old, those who carried rs1970801 T allele (genotype TT/GT) were associated with decreased breast cancer risk. In short, this case-control study provided the evidence that women with their first menstruation after 14 years old and carried rs1970801 T allele (genotype TT/GT) were associated with decreased breast cancer risk.

  19. The role of CSR engagement in the Internal Brand Building process : An exploratory study of Service firms

    OpenAIRE

    Emmanuel, Chidiebere; Eriksson, Eva

    2016-01-01

    This study explores how service firms incorporate CSR activities within the internal brand building process. It was found that CSR does influence and is implemented in every stage of our theoretical framework of the internal brand building process. The study was based on interviews conducted on managers and employees of service firms in the Netherlands and in Sweden.  CSR is an evolving concept, increasingly becoming important in affecting the consumption decisions of service firm’s customers...

  20. 中国100强企业社会责任发展状况评价%Evaluating the Level of Responsibility Management and CSR Information Disclosure of Top 100 Companies in China

    Institute of Scientific and Technical Information of China (English)

    黄群慧; 彭华岗; 钟宏武; 张蒽

    2009-01-01

    Based on the classic CSR theory of triple bottom line and stakeholders, this paper develops a "four in one" model which consists of responsibility management, economic, social and environmental responsibility. By analyzing the major international CSR indexes, national CSR initiatives and CSR reports of Fortune 500, we build the index systems of CSR evaluation for different industries, and then evaluate the level of responsibility management and CSR information disclosure of top 100 companies in China, according to the information from CSR reports, annual reports and official sites. This paper concludes that: ①the level of responsibility management and CSR information disclosure of 2/3 Chinese top 100 is low; ②the performance of responsibility management is poorer that of responsibility practices; ③the CSR index of central enterprises and state-owned financial companies is far higher than that of private, other state-owned and overseas-funded enterprises; ④firm size is in direct proportion to CSR index; ⑤the CSR indexes of different industrials are distinct, that the grid industry and electric power industry are leaders, however, the majority industries are still at the stage of participation.%本研究根据"三重底线"(Triple Bottom Line)和利益相关方理论(StakeholdersTheory)等经典的社会责任理论构建出一个责任管理、市场责任、社会责任、环境责任"四位一体"的理论模型,通过对标分析国际社会责任指数、国内社会责任倡议文件和世界500强企业社会责任报告构建出分行业的社会责任评价指标体系,以企业社会责任报告、企业年报、企业官方网站为信息来源,评价中国100强企业的社会责任管理体系建设现状和责任信息披露水平.评价结果显示:[1]约2/3的企业责任管理落后、责任信息披露不足;[2]企业责任管理显著落后于责任实践:[3]社会责任指数的企业性质差异明显,中央企业和国有金融企业

  1. CSR1, the sole target of imidazolinone herbicide in Arabidopsis thaliana.

    Science.gov (United States)

    Manabe, Yuzuki; Tinker, Nicholas; Colville, Adam; Miki, Brian

    2007-09-01

    The imidazolinone-tolerant mutant of Arabidopsis thaliana, csr1-2(D), carries a mutation equivalent to that found in commercially available Clearfield crops. Despite their widespread usage, the mechanism by which Clearfield crops gain imidazolinone herbicide tolerance has not yet been fully characterized. Transcription profiling of imazapyr (an imidazolinone herbicide)-treated wild-type and csr1-2(D) mutant plants using Affymetrix ATH1 GeneChip microarrays was performed to elucidate further the biochemical and genetic mechanisms of imidazolinone resistance. In wild-type shoots, the genes which responded earliest to imazapyr treatment were detoxification-related genes which have also been shown to be induced by other abiotic stresses. Early-response genes included steroid sulfotransferase (ST) and 1-aminocyclopropane-1-carboxylic acid oxidase (ACO), as well as members of the glycosyltransferase, glutathione transferase (GST), cytochrome P450, ATP-binding cassette (ABC) transporter, multidrug and toxin extrusion (MATE) and alternative oxidase (AOX) protein families. Later stages of the imazapyr response involved regulation of genes participating in biosynthesis of amino acids, secondary metabolites and tRNA. In contrast to the dynamic changes in the transcriptome profile observed in imazapyr-treated wild-type plants, the transcriptome of csr1-2(D) did not exhibit significant changes following imazapyr treatment, compared with mock-treated csr1-2(D). Further, no substantial difference was observed between wild-type and csr1-2(D) transcriptomes in the absence of imazapyr treatment. These results indicate that CSR1 is the sole target of imidazolinone and that the csr1-2(D) mutation has little or no detrimental effect on whole-plant fitness.

  2. A Study Of Influence Of Corporate Social Responsibility (CSR) Activities Of Firms In Consumer Purchasing Decision In Malaysia

    OpenAIRE

    Ahmad, Mashuk

    2003-01-01

    Most of the corporate social responsibility (CSR) studies conducted so far have been in the context of developed countries. Very few studies are available on the CSR practices in Malaysia which are in the context of company perspective. No study was found about CSR from the consumer’s point of view conducted in Malaysia. Since consumers are the real contributors to the firm’s revenue and profit, it is important to learn about their views on the practices of CSR. Research in this area is parti...

  3. The RNA-binding protein CsrA plays a central role in positively regulating virulence factors in Erwinia amylovora

    OpenAIRE

    Veronica Ancona; Jae Hoon Lee; Youfu Zhao

    2016-01-01

    The GacS/GacA two-component system (also called GrrS/GrrA) is a global regulatory system which is highly conserved among gamma-proteobacteria. This system positively regulates non-coding small regulatory RNA csrB, which in turn binds to the RNA-binding protein CsrA. However, how GacS/GacA-Csr system regulates virulence traits in E. amylovora remains unknown. Results from mutant characterization showed that the csrB mutant was hypermotile, produced higher amount of exopolysaccharide amylovoran...

  4. CSR and technology companies: A study on its implementation, integration and effects on the competitiveness of companies

    Directory of Open Access Journals (Sweden)

    Juan Andres Bernal-Conesa

    2016-11-01

    Full Text Available Purpose: In this paper, a structural equation model is presented in order to explain the motivations of implementing Corporate Social Responsibility (CSR in Spanish technology companies and its linkage with others standardized management systems before CSR implementation. It also examines whether CSR influences the competitiveness of these companies. Design/methodology/approach: The study was conducted in companies located in Spanish Science and Technology Parks. For this study, a survey was sent and structural equation model was used. Findings and Originality/value: Model results show that there is a positive, direct and statistically significant relationship between the motivations, previous management systems, implementation of CSR and the real integration of CSR in the organization. Research limitations/implications: Limitations are determined by the technique used for the proposed model: structural equations, which assume linearity of the relationship between latent variables. Practical implications: Companies can use the results of this study as a foothold to enhance the integration of CSR based on previous management systems and take advantage of synergies between them, since the integration of CSR has a direct relationship with the competitiveness of the company. Originality/value: The link between the motivations of CSR, CSR actions and their integration in technology companies are reliably and empirically demonstrated.

  5. The Csr/Rsm system of Yersinia and related pathogens: a post-transcriptional strategy for managing virulence.

    Science.gov (United States)

    Heroven, Ann Kathrin; Böhme, Katja; Dersch, Petra

    2012-04-01

    This review emphasizes the function and regulation of the Csr regulatory system in the human enteropathogen Yersinia pseudotuberculosis and compares its features with the homologous Csr/Rsm systems of related pathogens. The Csr/Rsm systems of eubacteria form a complex regulatory network in which redundant non-translated Csr/Rsm-RNAs bind the RNA-binding protein CsrA/RsmA, thereby preventing its interaction with mRNA targets. The Csr system is controlled by the BarA/UvrY-type of two-component sensor-regulator systems. Apart from that, common or pathogen-specific regulators control the abundance of the Csr components. The coordinate control of virulence factors and infection-linked physiological traits by the Csr/Rsm systems helps the pathogens to adapt individually to rapidly changing conditions to which they are exposed during the different stages of an infection. As Csr/Rsm function is relevant for full virulence, it represents a target suitable for antimicrobial drug development.

  6. [Scientific collaboration between Istituto Superiore di Sanità and Italian Association of Cancer Registries for the study of cancer incidence in Italian polluted sites].

    Science.gov (United States)

    Comba, P; Crocetti, E; Buzzoni, C; Fazzo, L; Ferretti, S; Fusco, M; Iavarone, I; Pirastu, R; Ricci, P

    2011-01-01

    The collaborative study between Istituto superiore di sanità and Associazione italiana registri tumori (ISS-AIRTUM) aims at investigating cancer incidence in polluted sites for adults and for children (0-14 years) and adolescents (15-19 years) to comment the study results in the light of a set of a priori hypotheses. On the whole, 141 out of 298 municipalities included in SENTIERI Project are served by a Cancer Register participating to the AIRTUM network. For a description of SENTIERI, refer to the 2010 Supplement of Epidemiology & Prevention devoted to SENTIERI Project. The time window of the study is the period 1996-2005. The number of expected cases in each polluted site will be estimated by applying incidence rates of the national pool of cancer registries and of the pool of the geographic macroarea in which each site is located: Northern, Central, Southern Italy and Islands. Cancer incidence in children and adolescents is one of the main priorities of international public health institutions, because of the need to protect childhood health from involuntary exposure to environmental risk factors. Standardized incidence ratios (SIRs) will be computed using expected figures derived from the national pool of cancer registries.

  7. The concept of CSR in accounting theory and practice in Poland: an empirical study 

    Directory of Open Access Journals (Sweden)

    Małgorzata Macuda

    2015-11-01

    Full Text Available Purpose. Right now, the issue of Corporate Social Responsibility (CSR lies within the scope of interest of various fields of social science and practice, including the science and practice of accounting. Numerous research works stress how accounting, particularly in terms of corporate reporting, is closely connected to the concept of CSR. The number of studies concerning especially CSR reporting has increased in recent years all over the world, but in Poland CSR reporting is a new field not yet covered by many current research papers. The main purpose of this work is to present the concept of CSR in the theory and practice of accounting. Design/methodology/approach. The research paper comprises a literature review and a content analysis. The literature review was conducted in the first part of the work, which was devoted to the presentation of the idea of corporate social responsibility in the context of accounting and corporate reporting, and also in the second part, which contains an overview of the most well-known and comprehensive global standards related to CSR reporting. The content analysis was used in the final part of the work to examine the disclosures of CSR in annual reports and separate reports (Management commentary, communications on a population of Polish stock exchange companies listed on the Warsaw Stock Exchange (WSE Main Market as of 31 October 2013, which are also listed in the WIG-Poland index and the RESPECT Index –the first Polish, and one of the few European indexes of socially responsible companies. Findings. It has been determined that among Polish public companies listed on the WSE, which are also listed in the WIG-Poland index, only 6% operate in a socially responsible manner according to the RESPECT criteria, and less than 4.6% of all companies listed in the WIG-Poland and 70% of RESPECT index companies prepare separate CSR reports. Out of all the companies that prepare separate CSR reports, 93% prepare ESG

  8. Surgical-site infections and postoperative complications: agreement between the Danish Gynecological Cancer Database and a randomized clinical trial

    DEFF Research Database (Denmark)

    Antonsen, Sofie L; Meyhoff, Christian Sylvest; Lundvall, Lene;

    2011-01-01

    : Evaluation study. SETTING: Danish Gynecological Cancer Database (DGCD) and the Danish multicenter trial on perioperative oxygen and surgical-site infections (PROXI). SAMPLE: Paired data from 222 patients who participated in the PROXI trial taking place at Copenhagen University Hospital, Rigshospitalet...

  9. CSR-1 RNAi pathway positively regulates histone expression in C. elegans.

    Science.gov (United States)

    Avgousti, Daphne C; Palani, Santhosh; Sherman, Yekaterina; Grishok, Alla

    2012-10-03

    Endogenous small interfering RNAs (endo-siRNAs) have been discovered in many organisms, including mammals. In C. elegans, depletion of germline-enriched endo-siRNAs found in complex with the CSR-1 Argonaute protein causes sterility and defects in chromosome segregation in early embryos. We discovered that knockdown of either csr-1, the RNA-dependent RNA polymerase (RdRP) ego-1, or the dicer-related helicase drh-3, leads to defects in histone mRNA processing, resulting in severe depletion of core histone proteins. The maturation of replication-dependent histone mRNAs, unlike that of other mRNAs, requires processing of their 3'UTRs through an endonucleolytic cleavage guided by the U7 snRNA, which is lacking in C. elegans. We found that CSR-1-bound antisense endo-siRNAs match histone mRNAs and mRNA precursors. Consistently, we demonstrate that CSR-1 directly binds to histone mRNA in an ego-1-dependent manner using biotinylated 2'-O-methyl RNA oligonucleotides. Moreover, we demonstrate that increasing the dosage of histone genes rescues the lethality associated with depletion of CSR-1 and EGO-1. These results support a positive and direct effect of RNAi on histone gene expression.

  10. An experimental test of CSR theory using a globally calibrated ordination method.

    Science.gov (United States)

    Li, Yuanzhi; Shipley, Bill

    2017-01-01

    Can CSR theory, in conjunction with a recently proposed globally calibrated CSR ordination ("StrateFy"), using only three easily measured leaf traits (leaf area, specific leaf area and leaf dry matter content) predict the functional signature of herbaceous vegetation along experimentally manipulated gradients of soil fertility and disturbance? To determine this, we grew 37 herbaceous species in mixture for five years in 24 experimental mesocosms differing in factorial levels of soil resources (stress) and density-independent mortality (disturbance). We measured 16 different functional traits and then ordinated the resulting vegetation within the CSR triangle using StrateFy. We then calculated community-weighted mean (CWM) values of the competitor (CCWM), stress-tolerator (SCWM) and ruderal (RCWM) scores for each mesocosm. We found a significant increase in SCWM from low to high stress mesocosms, and an increase in RCWM from lowly to highly disturbed mesocosms. However, CCWM did not decline significantly as intensity of stress or disturbance increased, as predicted by CSR theory. This last result likely arose because our herbaceous species were relatively poor competitors in global comparisons and thus no strong competitors in our species pool were selectively favoured in low stress and low disturbed mesocosms. Variation in the 13 other traits, not used by StrateFy, largely argeed with the predictions of CSR theory. StrateFy worked surprisingly well in our experimental study except for the C-dimension. Despite loss of some precision, it has great potential applicability in future studies due to its simplicity and generality.

  11. Does Business Model Affect CSR Involvement? A Survey of Polish Manufacturing and Service Companies

    Directory of Open Access Journals (Sweden)

    Marzanna Katarzyna Witek-Hajduk

    2016-02-01

    Full Text Available The study explores links between types of business models used by companies and their involvement in CSR. As the main part of our conceptual framework we used a business model taxonomy developed by Dudzik and Witek-Hajduk, which identifies five types of models: traditionalists, market players, contractors, distributors, and integrators. From shared characteristics of the business model profiles, we proposed that market players and integrators will show significantly higher levels of involvement in CSR than the three other classes of companies. Among other things, both market players and integrators relied strongly on building own brand value and fostering harmonious supply channel relations, which served as a rationale for our hypothesis. The data for the study were obtained through a combined CATI and CAWI survey on a group of 385 managers of medium and large enterprises. The sample was representative for the three Polish industries of chemical manufacturing, food production, and retailing. Statistical methods included confirmatory factor analysis and one-way ANOVA with contrasts and post hoc tests. The findings supported our hypothesis, showing that market players and integrators were indeed more engaged in CSR than other groups of firms. This may suggest that managers in control of these companies could bolster the integrity of their business models by increasing CSR involvement. Another important contribution of the study was to propose and validate a versatile scale for assessing CSR involvement, which showed measurement invariance for all involved industries.

  12. CSR Initiatives in two Higher Education Institutions from Belgium and Romania

    Directory of Open Access Journals (Sweden)

    Laurent LAHAYE

    2012-11-01

    Full Text Available The paper reveals the strategic role of CSR in two higher education institutions from Belgium and Romania - ICHEC Brussels Management School and Faculty of Economics and Business Administration Galati as institutions which influence sustainable development, by proving their implications in training students as future responsible citizens. Our main goal of this study was not to realise a comparative analysis of CSR initiatives managed by these two faculties, as we focused our attention on the emphasis of the outcomes related to the CSR projects, in the context in which they were designed in a totally different manner. ICHEC Housing Project provides to the students from ICHEC Brussels Management School the experience of intercultural openness, making them take part of a social work and be conscious of the reality in three countries from South: India, Burkina Faso and Benin. Within the CSR workshop organized by Faculty of Economics and Business Administration from Galati, in partnership with a NGO and four participants from Turkey, Bulgaria, France and Austria helps the students to achieve and develop their skills related to the tools, methods and procedures which can be used in CSR operational management. The project aims at increasing the level of implication of citizens in the process of sustainable development. We are aware that each project described in this paper could be considered as a model and replicated by other higher education institutions from worldwide.

  13. ANALISIS KEBERHASILAN PROGRAM PERLUASAN KEBUN KARET BIBIT UNGGUL CSR PT. ADARO INDONESIA

    Directory of Open Access Journals (Sweden)

    Hapijuddin Noor

    2016-10-01

    Full Text Available The concept of CSR based on the values of participation, empowerment, and self-sufficiency (self reliance in society is inseparable from the actual conditions and needs of the local community. One of the CSR programs undertaken by PT Adaro is people's rubber plantation development program by using seeds. Research done by conducting interviews of 36 people respondents specified in purposif to the community garden expansion program recipients rubber seeds PT Adaro Indonesia CSR in 2 (two location of research, namely: Murung Pudak Subdistrict and Upau Subdistrict and the province of South Kalimantan. The results showed that success of the expansion of Rubber Garden Superior CSR PT Adaro Indonesia. seen from the aspect of the cultivation is high. The success of the expansion of Rubber Garden Superior CSR PT Adaro Indonesia. high as seen from socio-economic and cultural aspects of institutional is high. In order for the success that has been achieved can be maintained and upgraded again especially to aspect institutional, which needs to be done coaching, supervision and guidance on an ongoing basis to the existing institutional.

  14. CSR and the Frontline Context: How Social Programs Improve Customer Service

    Directory of Open Access Journals (Sweden)

    Korschun Daniel

    2016-05-01

    Full Text Available CSR activities such as charitable giving, environmental programs and ethical practices can motivate frontline employees. One of the key variables is organizational identification. CSR communicates values, and, if these values are consistent with a person’s own value system, it results in higher identification with the company. Employees who notice that consumers are fond of the company’s CSR activities will identify even more with the company. If CSR ranks high in their own personal value system and the value system of the consumer as well, they find common ground for conversations beyond immediate business talk. CSR can be an icebreaker in conversations with customers. Once service employees find out that customers share their passion for social or environmental causes, it creates a bond that is highly motivating. They become more confident that they know what the customers want. They are more motivated to serve those customers when they see that both of them care about the same sorts of things.

  15. Selection of optimal antisense accessible sites of survivin and its application in treatment of gastric cancer

    Institute of Scientific and Technical Information of China (English)

    Qiang-Song Tong; Li-Duan Zheng; Fang-Min Chen; Fu-Qing Zeng; Liang Wang; Ji-Hua Dong; Gong-Cheng Lu

    2005-01-01

    AIM: To select the optimal antisense accessible sites of survivin, a highly expressed gene in tumor tissues, in order to explore a novel approach to improve biological therapy of gastric cancer.METHODS: The 20 mer random oligonucleotide library was synthesized, hybridized with in vitro transcribed total survivin cRNA, then digested by RNase H. After primer extension and autoradiography, the antisense accessible sites (AAS) of survivin were selected. Then RNADraw software was used to analyze and choose the AAS with obvious stem-loop structures, according to which the complementary antisense oligonucleotides (AS-ODNs) were synthesized and transferred into survivin highly- expressing gastric cancer cell line MKN-45. Survivin expression was detected by RT-PCR and Western Blotting. Cellular growth activities were assayed by tetrazolium bromide (MTT)colorimetry. Cellular ultrastructure was observed by electronic microscopy, while apoptosis was detected by annexin V-FITC and propidium iodide staining flow cytometry.RESULTS: Thirteen AAS of survivin were selected in vitro.Four AAS with stem-loop structures were chosen, locating at 207-226 bp, 187-206 bp, 126-145 bp and 44-63 bp of survivin cDNA respectively. When compared with nontranfection controls, their corresponding AS-ODNs (AS-ODN1,AS-ODN2, AS-ODN3 and AS-ODN4) could reduce Survivin mRNA levels in MKN-45 cells by 54.3±1.1% (t= 6.12, P<0.01),86.1±1.0% (t= 5.27, P<0.01), 32.2±1.3% (t= 7.34, P<0.01)and 56.2±0.9% (t= 6.45, P<0.01) respectively, while survivin protein levels were decreased by 42.2±2.5% (t = 6.26,P<0.01), 75.4±3.1% (t= 7.11, P<0.01), 28.3±2.0% (t= 6.04,P<0.01) and 45.8±1.2% (t = 6.38, P<0.01) respectively.After transfection with 600 nmol/L AS-ODN1~AS-ODN4 for24 h, cell growth was inhibited by 28.12±1.54% (t= 7.62,P<0.01), 38.42±3.12% (t = 7.75, P<0.01), 21.46±2.63%(t= 5.94, P<0.01) and 32.12±1.77% (t= 6.17, P<0.01)respectively. Partial cancer cells presented the

  16. An interactive method for teaching business ethics, stakeholder theory and corporate social responsibility (CSR)

    DEFF Research Database (Denmark)

    Rendtorff, Jacob Dahl

    2015-01-01

    and Economics and Business Administration the author of this article is responsible for this seminar that integrates issues of CSR and the ethics of innovation into the teaching of corporate social responsibility, stakeholder management and business ethics. This research oriented seminar provides a unique......his paper presents a theoretical and practical approach to teaching business ethics, stakeholder management and CSR within the framework of the thematic seminar on business ethics and corporate social responsibility at Roskilde University. Within our programs in English of business studies...... possibility for teaching CSR with an integration of methodological, theoretical and practical dimensions of business ethics (Rendtorff 2009). The idea is that the thematic seminar represents a tutor supported frame for extended studies of business ethics, stakeholder management and the social aspects...

  17. Does CSR Improve Organization Financial Performance? Evidence from Nigeria Using Triangulation Analysis

    Directory of Open Access Journals (Sweden)

    Taiwo Adewale MURITALA

    2013-12-01

    Full Text Available The study examines the impact of corporate social responsibility (CSR on organizational financial performance of some selected banks in Nigeria using time series of annual data of ten banks over the period of 1990 to 2010. Pearson Correlation coefficient was used to analyse the correlation that exist between CSR and organization performance while collected data were regressed using Ordinary Least Square technique. Findings indicate a positive relationship between CSR cost and Profit after Tax (PAT. The study therefore recommends that top management in an organization must ensure prudence in its spending and get committed to any social activity it wants to embark upon and allow the members of the public to associate such an activity or activities.

  18. ANALYSIS OF COMPANY SIZE, FINANCIAL LEVERAGE, AND PROFITABILITY AND ITS EFFECT TO CSR DISCLOSURE

    Directory of Open Access Journals (Sweden)

    Suskim Riantani

    2015-09-01

    Full Text Available This study aims to analyze and recognize the effect of financial performance measured through company size, financial leverage and profitability to Corporate Social Responsibility Disclosure (CSRD. The research was done in Tobacco Company listed in Indonesia Stock Exchange during period of 2007-2011. Descriptive analysis and verification method was used as the research method. The purposive sampling method was used to obtain the sample and there are three cigarette companies as the sample. Multiple linear regression and correlation analysis using t test and F test were applied as a technique of analysis. The test of the classical assumption such as the normality, multicollinearity, heteroscedasticity, and autocorrelation applied before the multiple linear regression. The result shows that the company size had positive and significant effect to the CSR disclosure, financial leverage does not show significant effect to the CSR disclosure, profitability does not have significant effect to the CSR disclosure during the investigation.

  19. Prospects for searching the η→e+e- rare decay at the CSR

    Institute of Scientific and Technical Information of China (English)

    JI Chang-Sheng; SHAO Ming; ZHANG Hui; CHEN Hong-Fang; ZHANG Yi-Fei

    2013-01-01

    We study the possibility of searching the η→e+e-rare decay on the Cooling Storage Ring (CSR) at Lanzhou.The main features of the proposed Internal Target Experiment (ITE) and External Target Facility (ETF)are included in the Monte Carlo simulation.Both the beam condition at the CSR and the major physics backgrounds are carefully taken into account.We conclude that the ITE is more suitable for such a study due to better detector acceptance and higher beam density.At the maximum designed luminosity (1034 cm-2s-1),η→e+e-events can be collected every ~400 seconds at the CSR.With a mass resolution of 1 MeV,the expected signal-to-background (S/B)ratio is around 1.

  20. CSR and Financial Performance: The Case of Polish Small and Medium Manufacturers

    Directory of Open Access Journals (Sweden)

    Zaborek Piotr

    2014-09-01

    Full Text Available The paper explores the hypothesized link between involvement in social responsibility and financial performance. In particular, it looks at this relationship among Polish small and medium manufacturing companies that operate in food, beverage and cosmetics industries. The statistical analysis involves developing and testing structural model on the basis of data from a survey of 187 managers supplemented by validated financial metrics from an external database. The outcomes suggests the existence of a weak but statistically significant positive correlation between the CSR involvement construct and sales profit margin (β=0.2. However, CSR seems to have no discernible direct effect on ROA. The study, as the first project of this kind in Poland, adds to the sparse body of literature on financial outcomes of CSR in small and medium enterprises from emerging economies. Another distinguishing feature of this research is its methodological approach which compares favorably to many previous studies in terms of robustness.

  1. PERFORMANCE INDICATORS IN CSR IN ROMANIA - A LINK TO THE GREEN ECONOMY

    Directory of Open Access Journals (Sweden)

    ALINA-MIHAELA BABONEA

    2012-11-01

    Full Text Available CSR (Corporate Social Responsibility has become a debated subject for public authorities, and also for private companies in the recent years especially as solution to overcome the financial crisis. We seek to create a preoccupation for this domain in Romania, by attracting the public opinion in promoting this concept. As a new concept for Romania, the CSR is a new vision implemented by companies which want to show more to their clients and to the society. These companies are willing to develop their business objectives around activities that support the environment and the society as a new trend in economic activity. The aim of this study is to explain the results of CSR indicators in Romania in the last years and to show the connection between these indicators and the green economy.

  2. Corporation as Civil Organization in a CSR Campaign: The Challenge of Maintaining Credibility

    DEFF Research Database (Denmark)

    Trapp, Leila

    2011-01-01

    , governments and civil society (Van Marrewijk, 2003). Within this framework, the case study contributes to our understanding of the motivation for the increasing number of CSR partnerships between business and Non-Governmental Organizations (NGOs) (Googins & Rochlin, 2000). More specifically, the analysis...... reveals that if a corporate CSR campaign fosters and enacts a blurring, or even elimination, of sector boundaries to reach campaign aims, important inherent distinctions between business, government, and civil organizations ultimately remain salient to the public. Unless these sector distinctions...... are recognized and maintained in CSR campaigns, challenges to a company’s credibility and reputation can arise. Key words: corporate social responsibility, corporate communication, cross-sector partnerships, corporate sustainability, campaigns, collaboration Paper type: case study Googins, B. K., Rochlin, S. A...

  3. An interactive method for teaching business ethics, stakeholder theory and corporate social responsibility (CSR)

    DEFF Research Database (Denmark)

    Rendtorff, Jacob Dahl

    2015-01-01

    his paper presents a theoretical and practical approach to teaching business ethics, stakeholder management and CSR within the framework of the thematic seminar on business ethics and corporate social responsibility at Roskilde University. Within our programs in English of business studies...... and Economics and Business Administration the author of this article is responsible for this seminar that integrates issues of CSR and the ethics of innovation into the teaching of corporate social responsibility, stakeholder management and business ethics. This research oriented seminar provides a unique...... possibility for teaching CSR with an integration of methodological, theoretical and practical dimensions of business ethics (Rendtorff 2009). The idea is that the thematic seminar represents a tutor supported frame for extended studies of business ethics, stakeholder management and the social aspects...

  4. The Relationship of CSR and Financial Performance: New Evidence from Indonesian Companies

    Directory of Open Access Journals (Sweden)

    Hasan Fauzi

    2009-06-01

    Full Text Available The research objectives of the study are to investigate whether there are any positive relationships between CFP and CSR under the slack resource theory and to investigate whether there are any positive relationships between CSR and CFP under good management theory by integrating concept of strategic management into the definition of CSR as sustainable corporate performance including economy, social, and environment. To answer the research questions of this study, questionnaire-based survey research design was used. The questionnaires that include items representing variables in this study (corporate social performance, corporate financial performance, business environment, strategy, organization structure, and control system were sent to the respondents who are managers of state-owned companies (BUMN and private-owned companies using post and e-mail services. There is a positive relationship between CFP and CSP under the slack resource theory and under good management theory.

  5. Corporate social responsibility : legal and semi-legal frameworks supporting CSR : developments 2000-2010 and Case Studies

    NARCIS (Netherlands)

    Lambooij, Tineke Elisabeth

    2010-01-01

    Corporate social responsibility (CSR) as a nominal term clearly resonates with scholars and practitioners alike. As a scientific concept, however, it has often been criticized for its lack of definitional precision and poor measurement. The upshot of this analysis is that since the CSR concept adds

  6. Islamic Corporate Social Responsibility (i-CSR Framework from the Perspective of Maqasid al- Syariah and Maslahah

    Directory of Open Access Journals (Sweden)

    Faizah Darus

    2013-06-01

    Full Text Available The rationale behind the establishment of Islamic organisations globally is based on the precept that Islamic organisations’ practices are conducted in accordance with the strict values and principles of Syariah. In line with this premise, the Corporate Social Responsibility (CSR policies and practices of Islamic organisations should be underpinned by Islamic laws and principles as revealed in the Qur’an and the Sunnah. Drawing on the doctrine of Maqasid alSyariah and the concept of Maslahah, this study proposes an Islamic CSR (i-CSR conceptual framework that will align the CSR policies and practices of Islamic organisations with the principles and values of Islam. The two conceptions are integrated with the CSR dimensions resulting in the prioritization of CSR practices based on Syariah principles. This study provides a structured approach to CSR policies and practices for Islamic organisations to ensure full compliance with Islamic principles.  Such a conceptual framework would be of interest to Islamic organisations worldwide and regulatory authorities in countries that are hosts to Islamic organisations to improve CSR policies, practices and disclosure on the part of Islamic organisations.

  7. Maintaining the CSR-identity of Sustainable Entrepreneurial Firms: The role of corporate governance in periods of business growth

    NARCIS (Netherlands)

    Roelofsen, M.; Blok, V.; Wubben, E.F.M.

    2015-01-01

    This chapter focuses on the maintenance of the CSR-identity of sustainable entrepreneurial firms (SEFs) during periods of business growth. Our aim is to explore to what extent corporate governance mechanisms can be seen as effective mechanisms to maintain the CSR-identity of growing SEFs. To this en

  8. Adaptation of Tri-molecular fluorescence complementation allows assaying of regulatory Csr RNA-protein interactions in bacteria.

    Science.gov (United States)

    Gelderman, Grant; Sivakumar, Anusha; Lipp, Sarah; Contreras, Lydia

    2015-02-01

    sRNAs play a significant role in controlling and regulating cellular metabolism. One of the more interesting aspects of certain sRNAs is their ability to make global changes in the cell by interacting with regulatory proteins. In this work, we demonstrate the use of an in vivo Tri-molecular Fluorescence Complementation assay to detect and visualize the central regulatory sRNA-protein interaction of the Carbon Storage Regulatory system in E. coli. The Carbon Storage Regulator consists primarily of an RNA binding protein, CsrA, that alters the activity of mRNA targets and of an sRNA, CsrB, that modulates the activity of CsrA. We describe the construction of a fluorescence complementation system that detects the interactions between CsrB and CsrA. Additionally, we demonstrate that the intensity of the fluorescence of this system is able to detect changes in the affinity of the CsrB-CsrA interaction, as caused by mutations in the protein sequence of CsrA. While previous methods have adopted this technique to study mRNA or RNA localization, this is the first attempt to use this technique to study the sRNA-protein interaction directly in bacteria. This method presents a potentially powerful tool to study complex bacterial RNA protein interactions in vivo.

  9. From the margins to the mainstream? - The potential for CSR cooperation in Angola and Nigeria[Corporate social responsibility

    Energy Technology Data Exchange (ETDEWEB)

    Oldgard, Mai; Pilch, Tony; Lunde, Leiv

    2004-07-01

    This paper argues that current cooperation between International Oil Companies (IOCs) on corporate social responsibility (CSR) in Angola and Nigeria is very limited. In spite of the same IOCs working on the same CSR agendas in the same countries, they rarely work together to enhance the cause of CSR. There are some exceptions, but in the vast majority of cases, IOCs continue to work in relative isolation when developing socially responsible business activity. This matters because companies and societies may stand to benefit from IOCs working together to promote CSR. Companies can benefit from being seen to work with each other, avoiding duplication and maximising opportunities. Societies may also benefit from IOCs working together; for instance on important community development projects, ensuring that services are developed where the need is greatest, and also, to the extent feasible, in conveying joint industry messages to the governments in question. The paper identifies a number of barriers to CSR cooperation, including: commercial drivers incentivising competition not cooperation, IOCs focusing on promotion of their own independent 'CSR' identity, and current arrangements encouraging cooperation with other agents, rather than between IOCs. The paper closes by proposing that multilateral agencies should help establish CSR Forums in countries like Angola and Nigeria, involving IOCs, state owned oil companies, industry associations, host governments and international governments. Such forums could work to identify key social and environmental needs, evaluate where IOCs are best placed to respond and, working together, drive greater levels of micro and macro CSR activity (author) (ml)

  10. The heavy ion cooler-storage-ring project (HIRFL-CSR) at Lanzhou

    CERN Document Server

    Xia, J W; Wei, B W; Yuan, Y J; Song, M T; Zhang, W Z; Yang, X D; Yuan Ping; Gao, D Q; Zhao, H W; Yang, X T; Xiao, G Q; Man, K T; Dang, J R; Cai, X H; Wang, Y F; Tang, J Y; Qiao, W M; Rao, Y N; He, Y; Mao, L Z; Zhou, Z Z

    2002-01-01

    HIRFL-CSR, a new ion Cooler-Storage-Ring (CSR) project, is the post-acceleration system of the Heavy Ion Research Facility in Lanzhou (HIRFL). It consists of a main ring (CSRm) and an experimental ring (CSRe). From the HIRFL cyclotron system the heavy ions will be accumulated, cooled and accelerated in the CSRm, then extracted fast to produce radioactive ion beams (RIB) or highly charged heavy ions. Those secondary beams will be accepted and stored by the CSRe for many internal-target experiments with electron cooling.

  11. Exploring the Rationales Expressed for Including a CSR Position to the Top Management Team

    DEFF Research Database (Denmark)

    Strand, Robert

    Recently, a number of positions with corporate social responsibility (CSR) in the position title have been introduced to the top management teams (TMTs) of some of the world’s largest corporations. I explore this phenomenon. I revisit 10 such positions identified in a previous study to add...... a longitudinal aspect. I then focus on three case companies from within this selection- H&M, Mattel, and Storebrand- whereby I employ the Weberian distinction between formal and substantive rationality to identify the rationales expressed by members of these TMTs for including a CSR position to the TMT...

  12. Simulations of the isochronous mass spectrometry at the HIRFL-CSR

    Science.gov (United States)

    Chen, R. J.; Yuan, Y. J.; Wang, M.; Xu, X.; Shuai, P.; Zhang, Y. H.; Yan, X. L.; Xing, Y. M.; Xu, H. S.; Zhou, X. H.; Litvinov, Yu A.; Litvinov, S.; Chen, X. C.; Fu, C. Y.; Ge, W. W.; Ge, Z.; Hu, X. J.; Huang, W. J.; Liu, D. W.; Zeng, Q.; Zhang, W.

    2015-11-01

    A Monte-Carlo simulation code, named as SimCSR, has been developed for the isochronous mass spectrometry experiments in the experimental storage ring (CSRe). The revolution times of the fragments ions stored in the CSRe, which were produced in the fragmentation of {}58{Ni} primary beam are reproduced very well by the SimCSR, although only linear components are considered. The standard deviation of the revolution time is found to be strongly affected by the phase slip factor, the width of the relative momentum difference and the instability of magnetic field. Based on the simulations, we outline and discuss the methods to reduce the standard deviation of the revolution time.

  13. A Study of Influence of Corporate Social Responsibility (Csr) and Advertisements with a Social Dimension of Firms in Consumer Purchase Intent in Malaysia

    OpenAIRE

    Syed Tahir, Sharifah Nur Adibah

    2006-01-01

    Most of the corporate social responsibility (CSR) studies conducted so far have been in the context of developed countries. Very few studies are available on the CSR practices in Malaysia which are in the context of company perspective. Fewer studies were found about CSR from the consumers’ point of view conducted in Malaysia. No study was found about CSR and advertising from the consumers’ point of view conducted in Malaysia. Research in this area is important as it will provide greater insi...

  14. Magnetic norbornene polymer as multiresponsive nanocarrier for site specific cancer therapy.

    Science.gov (United States)

    Rao N, Vijayakameswara; Ganivada, Mutyala Naidu; Sarkar, Santu; Dinda, Himadri; Chatterjee, Koushik; Dalui, Tanmoy; Das Sarma, Jayasri; Shunmugam, Raja

    2014-02-19

    A site-specific, stimuli-responsive nanocarrier has been synthesized by conjugating folate, magnetic particles and doxorubicin to the backbone of norbornene polymer. Monomers, namely, cis-5-norbornene-6-(diethoxyphosphoryl)hexanote (mono 1), norbornene grafted poly(ethyleneglycol)-folate (mono 2), and norbornene derived doxorubicin (mono 3) are carefully designed to demonstrate the smart nanorcarrier capabilities. The synthesis and complete characterization of all three monomers are elaborately discussed. Their copolymerization is done by controlled/living ring-opening metathesis polymerization (ROMP) to get the triblock copolymer PHOS-FOL-DOX. NMR spectroscopy and gel permeation chromatography confirm the formation of the triblock copolymer, while FT-IR spectroscopy, thermogravimetric analysis, along with transmission electron microscope confirm the anchoring of iron particle (Fe3O4) to the PHOS-FOL-DOX. Drug release profile shows the importance of having the hydrazone linker that helps to release the drug exactly at the mild acidic conditions resembling the pH of the cancerous cells. The newly designed nanocarrier shows greater internalization (about 8 times) due to magnetic field. Also, increased intracellular DOX release is observed due to the folate receptor. From these results, it is clear that PHOS-FOL-DOX has the potential to act as a smart nanoreservoir with the magnetic field guidance, folate receptor targeting, and finally pH stimulation.

  15. Incisional Surgical Site Infection after Elective Open Surgery for Colorectal Cancer

    Directory of Open Access Journals (Sweden)

    Kosuke Ishikawa

    2014-01-01

    Full Text Available Background. The purpose of this study was to clarify the incidence and risk factors for incisional surgical site infections (SSI in patients undergoing elective open surgery for colorectal cancer. Methods. We conducted prospective surveillance of incisional SSI after elective colorectal resections performed by a single surgeon for a 1-year period. Variables associated with infection, as identified in the literature, were collected and statistically analyzed for their association with incisional SSI development. Results. A total of 224 patients were identified for evaluation. The mean patient age was 67 years, and 120 (55% were male. Thirty-three (14.7% patients were diagnosed with incisional SSI. Multivariate analysis suggested that incisional SSI was independently associated with TNM stages III and IV (odds ratio [OR], 2.4 and intraoperative hypotension (OR, 3.4. Conclusions. The incidence of incisional SSI in our cohort was well within values generally reported in the literature. Our data suggest the importance of the maintenance of intraoperative normotension to reduce the development of incisional SSI.

  16. Worry Is Good for Breast Cancer Screening: A Study of Female Relatives from the Ontario Site of the Breast Cancer Family Registry

    Directory of Open Access Journals (Sweden)

    Li Rita Zhang

    2012-01-01

    Full Text Available Background. Few prospective studies have examined associations between breast cancer worry and screening behaviours in women with elevated breast cancer risks based on family history. Methods. This study included 901 high familial risk women, aged 23–71 years, from the Ontario site of the Breast Cancer Family Registry. Self-reported breast screening behaviours at year-one followup were compared between women at low (N=305, medium (N=433, and high (N=163 levels of baseline breast cancer worry using logistic regression. Nonlinear relationships were assessed using likelihood ratio tests. Results. A significant non-linear inverted “U” relationship was observed between breast cancer worry and mammography screening (P=0.034 for all women, where women at either low or high worry levels were less likely than those at medium to have a screening mammogram. A similar significant non-linear inverted “U” relationship was also found among all women and women at low familial risk for worry and screening clinical breast examinations (CBEs. Conclusions. Medium levels of cancer worries predicted higher rates of screening mammography and CBE among high-risk women.

  17. Campylobacter jejuni CsrA complements an Escherichia coli csrA mutation for the regulation of biofilm formation, motility and cellular morphology but not glycogen accumulation

    OpenAIRE

    Fields Joshua A; Thompson Stuart A

    2012-01-01

    Abstract Background Although Campylobacter jejuni is consistently ranked as one of the leading causes of bacterial diarrhea worldwide, the mechanisms by which C. jejuni causes disease and how they are regulated have yet to be clearly defined. The global regulator, CsrA, has been well characterized in several bacterial genera and is known to regulate a number of independent pathways via a post transcriptional mechanism, but remains relatively uncharacterized in the genus Campylobacter. Previou...

  18. 75 FR 64120 - Technical Amendments to Forms N-CSR and N-SAR in Connection With the Comprehensive Iran Sanctions...

    Science.gov (United States)

    2010-10-19

    ... COMMISSION 17 CFR Parts 249 and 274 Technical Amendments to Forms N-CSR and N-SAR in Connection With the... adopting technical amendments to Forms N-CSR and N-SAR under the Securities Exchange Act of 1934 and the... Securities and Exchange Commission (``Commission'') is adopting technical amendments to Form N-CSR \\1\\...

  19. Imaging Sites of Inhibition of Proteolysis in Pathomimetic Human Breast Cancer Cultures by Light-Activated Ruthenium Compound.

    Science.gov (United States)

    Ramalho, Suelem D; Sharma, Rajgopal; White, Jessica K; Aggarwal, Neha; Chalasani, Anita; Sameni, Mansoureh; Moin, Kamiar; Vieira, Paulo C; Turro, Claudia; Kodanko, Jeremy J; Sloane, Bonnie F

    2015-01-01

    The cysteine protease cathepsin B has been causally linked to progression and metastasis of breast cancers. We demonstrate inhibition by a dipeptidyl nitrile inhibitor (compound 1) of cathepsin B activity and also of pericellular degradation of dye-quenched collagen IV by living breast cancer cells. To image, localize and quantify collagen IV degradation in real-time we used 3D pathomimetic breast cancer models designed to mimic the in vivo microenvironment of breast cancers. We further report the synthesis and characterization of a caged version of compound 1, [Ru(bpy)2(1)2](BF4)2 (compound 2), which can be photoactivated with visible light. Upon light activation, compound 2, like compound 1, inhibited cathepsin B activity and pericellular collagen IV degradation by the 3D pathomimetic models of living breast cancer cells, without causing toxicity. We suggest that caged inhibitor 2 is a prototype for cathepsin B inhibitors that can control both the site and timing of inhibition in cancer.

  20. CXI-benzo-84 reversibly binds to tubulin at colchicine site and induces apoptosis in cancer cells.

    Science.gov (United States)

    Rai, Ankit; Gupta, Tilak Kumar; Kini, Sudarshan; Kunwar, Ambarish; Surolia, Avadhesha; Panda, Dulal

    2013-08-01

    Here, we have discovered CXI-benzo-84 as a potential anticancer agent from a library of benzimidazole derivatives using cell based screening strategy. CXI-benzo-84 inhibited cell cycle progression in metaphase stage of mitosis and accumulated spindle assembly checkpoint proteins Mad2 and BubR1 on kinetochores, which subsequently activated apoptotic cell death in cancer cells. CXI-benzo-84 depolymerized both interphase and mitotic microtubules, perturbed EB1 binding to microtubules and inhibited the assembly and GTPase activity of tubulin in vitro. CXI-benzo-84 bound to tubulin at a single binding site with a dissociation constant of 1.2±0.2μM. Competition experiments and molecular docking suggested that CXI-benzo-84 binds to tubulin at the colchicine-site. Further, computational analysis provided a significant insight on the binding site of CXI-benzo-84 on tubulin. In addition to its potential use in cancer chemotherapy, CXI-benzo-84 may also be useful to screen colchicine-site agents and to understand the colchicine binding site on tubulin.

  1. Thymineless death is inhibited by CsrA in Escherichia coli lacking the SOS response.

    Science.gov (United States)

    Hamilton, Holly M; Wilson, Ray; Blythe, Martin; Nehring, Ralf B; Fonville, Natalie C; Louis, Edward J; Rosenberg, Susan M

    2013-11-01

    Thymineless death (TLD) is the rapid loss of colony-forming ability in bacterial, yeast and human cells starved for thymine, and is the mechanism of action of common chemotherapeutic drugs. In Escherichia coli, significant loss of viability during TLD requires the SOS replication-stress/DNA-damage response, specifically its role in inducing the inhibitor of cell division, SulA. An independent RecQ- and RecJ-dependent TLD pathway accounts for a similarly large additional component of TLD, and a third SOS- and RecQ/J-independent TLD pathway has also been observed. Although two groups have implicated the SOS-response in TLD, an SOS-deficient mutant strain from an earlier study was found to be sensitive to thymine deprivation. We performed whole-genome resequencing on that SOS-deficient strain and find that, compared with the SOS-proficient control strain, it contains five mutations in addition to the SOS-blocking lexA(Ind(-)) mutation. One of the additional mutations, csrA, confers TLD sensitivity specifically in SOS-defective strains. We find that CsrA, a carbon storage regulator, reduces TLD in SOS- or SulA-defective cells, and that the increased TLD that occurs in csrA(-) SOS-defective cells is dependent on RecQ. We consider a hypothesis in which the modulation of nucleotide pools by CsrA might inhibit TLD specifically in SOS-deficient (SulA-deficient) cells.

  2. A model code on co-determination and CSR : The Netherlands: A bottom-up approach

    NARCIS (Netherlands)

    Lambooy, T.E.

    2011-01-01

    This article discusses the works council’s role in the determination of a company’s CSR strategy and the implementation thereof throughout the organisation. The association of the works councils of multinational companies with a base in the Netherlands has recently developed a ‘Model Code on Co-Dete

  3. Analysis on The Society Indicator of Corporate Social Responsibility (CSR of PT Antam

    Directory of Open Access Journals (Sweden)

    Nuraini Sari

    2013-11-01

    Full Text Available Stakeholders believe that CSR report of a company provides significant information as well as the financial information reported in financial statement. The purpose of this research is to analyze the comprehensiveness and information on society indicator stated in the Corporate Social Responsibility (CSR reporting. The Global Reporting Initiative’s (GRI Sustainability Reporting Guidelines (version 3.1 provides indicators to analyze the CSR of company. This research focuses on society aspect as one of the performance indicators. Comprehensive reporting contains three types of information: (i vision and goals, (ii management approach, and (iii performance indicator. The methodology used in this research was data collection. This research analyzed the disclosure of society aspect by PT Antam on their financial statement and annual CSR report for the year 2012. The result of this research explains that PT Antam’s sustainability report for the year 2012 was comprehensive because they reported all the six aspects of society indicator. However, PT Antam failed to report the total value of financial and in kind contributions to political parties, politicians, and related institutions by country (SO6 as part of public policy aspect in their sustainability report.

  4. Stakeholders’ responses to CSR tradeoffs: when other-orientation and trust trump material self-interest

    NARCIS (Netherlands)

    F. Bridoux; N. Stofberg; D. den Hartog

    2016-01-01

    When investing in corporate social responsibility (CSR), managers may strive for a win-win scenario where all stakeholders end up better off, but they may not always be able to avoid trading off stakeholders' interests. To provide guidance to managers who have to make tradeoffs, this study used a vi

  5. THE PROFILE OF CSR DISCLOSURE AS PRESENTED ON ROMANIAN COMPANIES’ WEBSITES

    Directory of Open Access Journals (Sweden)

    Saveanu Tomina Gabriela

    2015-07-01

    Full Text Available In this paper we present the main findings of a study on CSR disclosure by companies operating in Romania. Starting with the statement that an important incentive for social responsibility actions is represented by creating a good reputation for the company, we would expect high online visibility of these initiatives. More, based on the information available on companies’ websites we aimed at creating a typology for the CSR actions in Romania. Consequently we investigated websites of all large companies in Bihor County and the top 100 largest companies in Romania based on turnover. The analysis was systematized on the following information: concepts used, types of actions organized, reference stakeholders, elements of reporting. The conclusions are rather contradictory to the starting argument: for Romania the main driver for CSR actions seems to be the example and standards set by multinational companies not a PR strategy. Consequently such actions are less visible online and are not systematically reported. More, in many cases the lack of promotion or link between a company to a social cause indicates that CSR is the result of a social orientation of the owners or managers of companies. The concept most used in practice is sustainability, in some cases devided between environment and social components. The areas in which companies are most active are the environmental protection, sports and generally community development projects.

  6. Are narrative CSR disclosures relevant for investors? Empirical evidence from Germany

    NARCIS (Netherlands)

    Verbeeten, F.; Gamerschlag, R.; Möller, K.

    2014-01-01

    CSR disclosures relate to the provision of information on companies’ environmental and social performance to external stakeholders. Although such disclosures can be directed at several stakeholders other than the (potential) firm shareholders, they may be relevant for valuation purposes. Based on th

  7. Restoring stakeholders’ trust in multinationals’ tax planning practices with corporate social responsibility (CSR)

    NARCIS (Netherlands)

    Jallai, Ave-Geidi; Peeters, Bruno; Gribnau, Hans; Badisco, Jo

    2017-01-01

    This contribution discusses the tax planning behaviour of big corporations and investigates Corporate Social Responsibility (CSR) as a tool to battle the issue. It will be argued that certain legal tax planning strategies of multinationals are not acceptable to local communities and the public in ge

  8. An Entrepreneurial Learning Exercise as a Pedagogical Tool for Teaching CSR: A Peruvian Study

    Science.gov (United States)

    Farber, Vanina A.; Prialé, María Angela; Fuchs, Rosa María

    2015-01-01

    This paper reports on an exploratory cross-sectional study of the value of an entrepreneurial learning exercise as a tool for examining the entrepreneurship dimension of corporate social responsibility (CSR). The study used grounded theory to analyse diaries kept by graduate (MBA) students during the "20 Nuevos Soles Project". From the…

  9. CSR-i kommunikatsioon: komm või pomm? / Mari Valgepea

    Index Scriptorium Estoniae

    Valgepea, Mari

    2015-01-01

    Kuidas rääkida ettevõtte vastutustundlikkusest (CSR) nii, et seda ei tembeldataks PR-trikiks. Kahe vastutustunsliku ettevõtte, AS-i Tallinna Vesi ja Viru Keemia Grupi võimaluste ja libastumisohtude kohta jagavad selgitusi ettevõtete kommunikatsioonijuhid Mariliis Topp ja Irina Bojenko

  10. Classification and evaluation of some endemic plants from Turkey using Grime’s CSR strategies

    Directory of Open Access Journals (Sweden)

    Cengiz Yildirim

    2012-11-01

    Full Text Available Background: Functional traits play important roles in plant growth and survival. According to functional traits, there are several classification types for plants such as adaptive and demographic strategies. Material and Methods: In this study, eight endemic taxa were collected from the Amasya K�rklar Mountain in Turkey and were classified and evaluated by Grime’s CSR (Competitive, Stress tolerant, Ruderal strategy scheme. Results: These plants are in the LR(lc (Lower risk/least concern red list category and they are hemicryptophytes according to Raunkiaer’s life forms. The CSR strategies of Asyneuma limonifolium subsp. pestalozzae, Digitalis lamarckii, and Paracaryum ancyritanum were CR, Linaria corifolia and Scutellaria salviifolia were CR/CSR, Phlomis armeniaca was C/CR, and Sideritis dichotoma and Jurinea pontica were SC. Conclusions: CR, CR/CSR, and C/CR plants are resistant to competition and disturbance such as grazing, trampling, mowing, soil erosion, and fire, whereas, SC are resistant to competition and stress, for example drought.

  11. Two Approaches to Curriculum Development for Educating for Sustainability and CSR

    Science.gov (United States)

    Stubbs, Wendy; Schapper, Jan

    2011-01-01

    Purpose: The purpose of this paper is to report on efforts to develop two stand-alone subjects on sustainability and corporate social responsibility (CSR) in a mainstream business curriculum at Monash University, Australia. Design/methodology/approach: This paper presents details on the educational rationale and design of the two subjects in…

  12. CSR-1 and P granules suppress sperm-specific transcription in the C. elegans germline.

    Science.gov (United States)

    Campbell, Anne C; Updike, Dustin L

    2015-05-15

    Germ granules (P granules) in C. elegans are required for fertility and function to maintain germ cell identity and pluripotency. Sterility in the absence of P granules is often accompanied by the misexpression of soma-specific proteins and the initiation of somatic differentiation in germ cells. To investigate whether this is caused by the accumulation of somatic transcripts, we performed mRNA-seq on dissected germlines with and without P granules. Strikingly, we found that somatic transcripts do not increase in the young adult germline when P granules are impaired. Instead, we found that impairing P granules causes sperm-specific mRNAs to become highly overexpressed. This includes the accumulation of major sperm protein (MSP) transcripts in germ cells, a phenotype that is suppressed by feminization of the germline. A core component of P granules, the endo-siRNA-binding Argonaute protein CSR-1, has recently been ascribed with the ability to license transcripts for germline expression. However, impairing CSR-1 has very little effect on the accumulation of its mRNA targets. Instead, we found that CSR-1 functions with P granules to prevent MSP and sperm-specific mRNAs from being transcribed in the hermaphrodite germline. These findings suggest that P granules protect germline integrity through two different mechanisms, by (1) preventing the inappropriate expression of somatic proteins at the level of translational regulation, and by (2) functioning with CSR-1 to limit the domain of sperm-specific expression at the level of transcription.

  13. Protection of germline gene expression by the C. elegans Argonaute CSR-1.

    Science.gov (United States)

    Wedeles, Christopher J; Wu, Monica Z; Claycomb, Julie M

    2013-12-23

    In Caenorhabditis elegans, the Piwi-interacting small RNA (piRNA)-mediated germline surveillance system encodes more than 30,000 unique 21-nucleotide piRNAs, which silence a variety of foreign nucleic acids. What mechanisms allow endogenous germline-expressed transcripts to evade silencing by the piRNA pathway? One likely candidate in a protective mechanism is the Argonaute CSR-1, which interacts with 22G-small RNAs that are antisense to nearly all germline-expressed genes. Here, we use an in vivo RNA tethering assay to demonstrate that the recruitment of CSR-1 to a transcript licenses expression of the transcript, protecting it from piRNA-mediated silencing. Licensing occurs mainly at the level of transcription, as we observe changes in pre-mRNA levels consistent with transcriptional activation when CSR-1 is tethered. Furthermore, the recruitment of CSR-1 to a previously silenced locus transcriptionally activates its expression. Together, these results demonstrate a rare positive role for an endogenous Argonaute pathway in heritably licensing and protecting germline transcripts.

  14. CDE-1 affects chromosome segregation through uridylation of CSR-1-bound siRNAs.

    Science.gov (United States)

    van Wolfswinkel, Josien C; Claycomb, Julie M; Batista, Pedro J; Mello, Craig C; Berezikov, Eugene; Ketting, René F

    2009-10-02

    We have studied the function of a conserved germline-specific nucleotidyltransferase protein, CDE-1, in RNAi and chromosome segregation in C. elegans. CDE-1 localizes specifically to mitotic chromosomes in embryos. This localization requires the RdRP EGO-1, which physically interacts with CDE-1, and the Argonaute protein CSR-1. We found that CDE-1 is required for the uridylation of CSR-1 bound siRNAs, and that in the absence of CDE-1 these siRNAs accumulate to inappropriate levels, accompanied by defects in both meiotic and mitotic chromosome segregation. Elevated siRNA levels are associated with erroneous gene silencing, most likely through the inappropriate loading of CSR-1 siRNAs into other Argonaute proteins. We propose a model in which CDE-1 restricts specific EGO-1-generated siRNAs to the CSR-1 mediated, chromosome associated RNAi pathway, thus separating it from other endogenous RNAi pathways. The conserved nature of CDE-1 suggests that similar sorting mechanisms may operate in other animals, including mammals.

  15. The relationship of CSR and the business profit: can the most responsible companies be more profitable?

    Directory of Open Access Journals (Sweden)

    Antonio Miguel Gil Salmerón

    2016-10-01

    Full Text Available Persistent financial crisis and the cases of corruption afflicting Spain have broken the trust of society that forcefully demands an ethical, responsible and sustainable management of organizations, which are not immune to environmental problems. The effects of globalization, the introduction of tecnoestructura as a management model, technological and socio-economic changes have reshaped the cultural, management and ownership system of the current company, the company nowadays is transferred the responsibility to combine growth and competitiveness with social development and environmental improvement. This reconfiguration of business management model is implemented with the introduction of Corporate Social Responsibility (CSR in the strategic plans of the companies with the purpose of achieving a competitive advantage. The question is: can the most responsible companies be more profitable? The introduction of CSR in the organizational culture of the companies involved as a vector, accelerates the profitability of the companies that apply it: the higher level of CSR used, the more profitable the companies are. These conclusions are determined from a linear regression analysis comparing the ROA –return on assets– to CSR levels in a hundred companies with higher levels of sustainability that operate in Spain, according to a survey published in 2014 by the Monitor business Corporate Reputation (Merco

  16. Selecting a CSR Model: Quality and Implications of the Model Adoption Process

    Science.gov (United States)

    Le Floch, Kerstin Carlson; Zhang, Yu; Kurki, Anja; Herrmann, Suzannah

    2006-01-01

    The process through which a school adopts a comprehensive school reform (CSR) model has been suggested to be a key element in the lifecycle of school reform, contributing to stakeholder buy in and subsequent implementation. We studied the model adoption process, both on a national scale with survey data and in more depth with qualitative case…

  17. Brain metastases as site of first and isolated recurrence of breast cancer: the role of systemic therapy after local treatment.

    Science.gov (United States)

    Niwińska, Anna

    2016-10-01

    The role of systemic treatment was assessed after local therapy for breast cancer patients who developed central nervous system (CNS) metastases as a first and isolated recurrence. Subjects were 128 breast cancer patients with brain metastases as the first and isolated site of recurrence that were selected from 673 consecutive breast cancer patients with brain metastases treated at the same institution. Median survival from brain metastases in patients with and without systemic treatment after local therapy was respectively 15 and 4 months (p systemic treatment after local therapy, was respectively 22 and 7 months (p = 0.003). Cox multivariate analysis demonstrated that good performance status, solitary brain metastasis and systemic therapy undertaken after local treatment were factors which prolonged survival. However patient survival was adversely affected by those having leptomeningeal metastasis associated with brain parenchymal lesions. Systemic therapy, undertaken after local treatment improved survival in those patients with breast cancer and brain metastases as the site of first and isolated recurrence. Further study is required in order to fully establish the role of systemic treatment for this patient group.

  18. Ecological studies of cancer incidence in an area interested by dumping waste sites in Campania (Italy

    Directory of Open Access Journals (Sweden)

    Lucia Fazzo

    2011-01-01

    Full Text Available Cancer incidence was investigated in an area which has been affected by the illegal practices of dumping hazardous waste and setting fire to mismanaged waste. For the 35 municipalities of this area that are served by a Cancer Registry, municipal standardized incidence ratios (SIR and hierarchical Bayesian estimators (BIR were computed. Moreover, municipal spatial clustering and a Poisson regression by municipality index of waste-related exposure were performed for 10 cancer types. Increased municipality SIRs were found for some cancer types. The BIRs confirmed the increases for liver cancer in two municipalities. Statistically significant clusters were detected for liver, lung, leukaemia and soft tissue sarcomas. In the regression analysis, testis cancer showed significant trend with the index of waste-related exposure (RR = 1.18.

  19. Analyzing fit in CSR strategy research in state-owned entreprises: Indonesia context

    Directory of Open Access Journals (Sweden)

    Muafi Muafi

    2016-03-01

    Full Text Available Purpose: We attempted to empirically examine the fitness level of enterprises CSR strategy and its context with contingency and configuration approach. Furthermore, we used 213 CSR managers of state-owned enterprises in Indonesia as samples Design/methodology/approach: We used the purposive sampling technique to examine the data, also the contingency and configuration approach are measured with regression Euclidean distance. Findings: The result of the configuration and contingency approach has shown fit between CSR strategy and elements of contingency such as socialization tactic and time orientation. This condition also emerges on proactive CSR strategy and reactive CSR strategy, However, there are limitations of this study: an existence of the influence of the situation and condition when this study takes time; there is a concern on the result of not generalizing population, also the organizational performance only considered the size of organizational performance from non financial measure. Research limitation: (a respondents’ answers are highly influenced by situation and condition when the study takes time. Although validity and reliability tests has shown the right outcome, there is still a possibility of a bias, (b state-owned companies in Indonesia are represented by CSR manager samples or PKBL with purposive technique so there is a concern on the result for not generalizing population, (c this research only used primary data through questionnaires. It would be better to combine both primary and secondary data for future researches, (d  organizational performance only considered the size of organizational performance from non financial measure. Originality/value: There is a methodological contribution in testing the fit of a relationship, both contingency and configuration are superior in terms of research method which used Euclidean distance, and used multivariate fit and bivariate fit linear regression. This research model used

  20. Autophagy and TGF-Beta Antagonist Signaling in Breast Cancer at Premetastatic Sites

    Science.gov (United States)

    2015-06-01

    estrogen receptor- negative mammary tumors in mice. Journal of the National Cancer Institute 101, 107-113 (2009). 7. Borrell-Pages, M., Fernandez-Larrea...breast cancer cells in xenograft mouse models (months 1-12) 1a. To establish 4T07 cell lines harboring triple modality reporter gene and (1...reactivation of lung-disseminated breast cancer cells in mouse models (months 1-15) 3a. To establish 4T07 cell lines expressing triple modality reporter

  1. CsrA (BB0184) Is Not Involved in Activation of the RpoN-RpoS Regulatory Pathway in Borrelia burgdorferi

    OpenAIRE

    Ouyang, Zhiming; Zhou, Jianli; Norgard, Michael V.

    2014-01-01

    Borrelia burgdorferi encodes a homologue of the bacterial carbon storage regulator A (CsrA). Recently, it was reported that CsrA contributes to B. burgdorferi infectivity and is required for the activation of the central RpoN-RpoS regulatory pathway. However, many questions concerning the function of CsrA in B. burgdorferi gene regulation remain unanswered. In particular, there are conflicting reports concerning the molecular details of how CsrA may modulate rpoS expression and, thus, how Csr...

  2. Privacy Practices of Health Social Networking Sites: Implications for Privacy and Data Security in Online Cancer Communities.

    Science.gov (United States)

    Charbonneau, Deborah H

    2016-08-01

    While online communities for social support continue to grow, little is known about the state of privacy practices of health social networking sites. This article reports on a structured content analysis of privacy policies and disclosure practices for 25 online ovarian cancer communities. All of the health social networking sites in the study sample provided privacy statements to users, yet privacy practices varied considerably across the sites. The majority of sites informed users that personal information was collected about participants and shared with third parties (96%, n = 24). Furthermore, more than half of the sites (56%, n = 14) stated that cookies technology was used to track user behaviors. Despite these disclosures, only 36% (n = 9) offered opt-out choices for sharing data with third parties. In addition, very few of the sites (28%, n = 7) allowed individuals to delete their personal information. Discussions about specific security measures used to protect personal information were largely missing. Implications for privacy, confidentiality, consumer choice, and data safety in online environments are discussed. Overall, nurses and other health professionals can utilize these findings to encourage individuals seeking online support and participating in social networking sites to build awareness of privacy risks to better protect their personal health information in the digital age.

  3. Surgical site infections following colorectal cancer surgery: a randomized prospective trial comparing common and advanced antimicrobial dressing containing ionic silver

    Directory of Open Access Journals (Sweden)

    Biffi Roberto

    2012-05-01

    Full Text Available Abstract Background An antimicrobial dressing containing ionic silver was found effective in reducing surgical-site infection in a preliminary study of colorectal cancer elective surgery. We decided to test this finding in a randomized, double-blind trial. Methods Adults undergoing elective colorectal cancer surgery at two university-affiliated hospitals were randomly assigned to have the surgical incision dressed with Aquacel® Ag Hydrofiber dressing or a common dressing. To blind the patient and the nursing and medical staff to the nature of the dressing used, scrub nurses covered Aquacel® Ag Hydrofiber with a common wound dressing in the experimental arm, whereas a double common dressing was applied to patients of control group. The primary end-point of the study was the occurrence of any surgical-site infection within 30 days of surgery. Results A total of 112 patients (58 in the experimental arm and 54 in the control group qualified for primary end-point analysis. The characteristics of the patient population and their surgical procedures were similar. The overall rate of surgical-site infection was lower in the experimental group (11.1% center 1, 17.5% center 2; overall 15.5% than in controls (14.3% center 1, 24.2% center 2, overall 20.4%, but the observed difference was not statistically significant (P = 0.451, even with respect to surgical-site infection grade 1 (superficial versus grades 2 and 3, or grade 1 and 2 versus grade 3. Conclusions This randomized trial did not confirm a statistically significant superiority of Aquacel® Ag Hydrofiber dressing in reducing surgical-site infection after elective colorectal cancer surgery. Trial registration Clinicaltrials.gov: NCT00981110

  4. How Do Internal and External CSR Affect Employees' Organizational Identification? A Perspective from the Group Engagement Model.

    Science.gov (United States)

    Hameed, Imran; Riaz, Zahid; Arain, Ghulam A; Farooq, Omer

    2016-01-01

    The literature examines the impact of firms' corporate social responsibility (CSR) activities on employees' organizational identification without considering that such activities tend to have different targets. This study explores how perceived external CSR (efforts directed toward external stakeholders) and perceived internal CSR (efforts directed toward employees) activities influence employees' organizational identification. In so doing, it examines the alternative underlying mechanisms through which perceived external and internal CSR activities build employees' identification. Applying the taxonomy prescribed by the group engagement model, the study argues that the effects of perceived external and internal CSR flow through two competing mechanisms: perceived external prestige and perceived internal respect, respectively. Further, it is suggested that calling orientation (how employees see their work contributions) moderates the effects induced by these alternative forms of CSR. The model draws on survey data collected from a sample of 414 employees across five large multinationals in Pakistan. The results obtained using structural equation modeling support these hypotheses, reinforcing the notion that internal and external CSR operate through different mediating mechanisms and more interestingly employees' calling orientation moderates these relationships to a significant degree. Theoretical contributions and practical implications of results are discussed in detail.

  5. How Do Internal and External CSR Affect Employees' Organizational Identification? A Perspective from the Group Engagement Model

    Science.gov (United States)

    Hameed, Imran; Riaz, Zahid; Arain, Ghulam A.; Farooq, Omer

    2016-01-01

    The literature examines the impact of firms' corporate social responsibility (CSR) activities on employees' organizational identification without considering that such activities tend to have different targets. This study explores how perceived external CSR (efforts directed toward external stakeholders) and perceived internal CSR (efforts directed toward employees) activities influence employees' organizational identification. In so doing, it examines the alternative underlying mechanisms through which perceived external and internal CSR activities build employees' identification. Applying the taxonomy prescribed by the group engagement model, the study argues that the effects of perceived external and internal CSR flow through two competing mechanisms: perceived external prestige and perceived internal respect, respectively. Further, it is suggested that calling orientation (how employees see their work contributions) moderates the effects induced by these alternative forms of CSR. The model draws on survey data collected from a sample of 414 employees across five large multinationals in Pakistan. The results obtained using structural equation modeling support these hypotheses, reinforcing the notion that internal and external CSR operate through different mediating mechanisms and more interestingly employees' calling orientation moderates these relationships to a significant degree. Theoretical contributions and practical implications of results are discussed in detail. PMID:27303345

  6. How Do Internal and External CSR Affect Employees’ Organizational Identification? A Perspective From the Group Engagement Model

    Directory of Open Access Journals (Sweden)

    Imran eHameed

    2016-05-01

    Full Text Available The literature examines the impact of firms’ corporate social responsibility (CSR activities on employees’ organizational identification without considering that such activities tend to have different targets. This study explores how perceived external CSR (efforts directed towards external stakeholders and perceived internal CSR (efforts directed towards employees activities influence employees’ organizational identification. In so doing, it examines the alternative underlying mechanisms through which perceived external and internal CSR activities build employees’ identification. Applying the taxonomy prescribed by the group engagement model, the study argues that the effects of perceived external and internal CSR flow through two competing mechanisms: perceived external prestige and perceived internal respect, respectively. Further, it is suggested that calling orientation (how employees see their work contributions moderates the effects induced by these alternative forms of CSR. The model draws on survey data collected from a sample of 414 employees across five large multinationals in Pakistan. The results obtained using structural equation modeling support these hypotheses, reinforcing the notion that internal and external CSR operate through different mediating mechanisms and more interestingly employees’ calling orientation moderates these relationships to a significant degree. Theoretical contributions and practical implications of results are discussed in detail.

  7. Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation

    Directory of Open Access Journals (Sweden)

    Koeffler Phillip

    2010-02-01

    Full Text Available Abstract Background Epigenetic changes associated with promoter DNA methylation results in silencing of several tumor suppressor genes that lead to increased risk for tumor formation and for progression of the cancer. Methods Methylation specific PCR (MSP and bisulfite sequencing were used for determination of proapoptotic gene Caspase 8 (CASP8 and the tumor suppressor gene maspin promoter methylation in four breast cancer and two non-tumorigenic breast cell lines. Involvement of histone H3 methylation in those cell lines were examined by CHIP assay. Results The CpG sites in the promoter region of CASP8 and maspin were methylated in all four breast cancer cell lines but not in two non-tumorigenic breast cell lines. Demethylation agent 5-aza-2'-deoxycytidine (5-aza-dc selectively inhibits DNA methyltransferases, DNMT3a and DNMT3b, and restored CASP8 and maspin gene expression in breast cancer cells. 5-aza-dc also reduced histone H3k9me2 occupancy on CASP8 promoter in SKBR3cells, but not in MCF-7 cells. Combination of histone deacetylase inhibitor Trichostatin A (TSA and 5-aza-dc significant decrease in nuclear expression of Di-methyl histone H3-Lys27 and slight increase in acetyl histone H3-Lys9 in MCF-7 cells. CASP8 mRNA and protein level in MCF-7 cells were increased by the 5-aza-dc in combination with TSA. Data from our study also demonstrated that treatment with 5-FU caused a significant increase in unmethylated CASP8 and in CASP8 mRNA in all 3 cancer lines. Conclusions CASP8 and maspin expression were reduced in breast cancer cells due to promoter methylation. Selective application of demethylating agents could offer novel therapeutic opportunities in breast cancer.

  8. The carbon storage regulator (Csr system exerts a nutrient-specific control over central metabolism in Escherichia coli strain Nissle 1917.

    Directory of Open Access Journals (Sweden)

    Olga Revelles

    Full Text Available The role of the post-transcriptional carbon storage regulator (Csr system in nutrient utilization and in the control of the central metabolism in E. coli reference commensal strain Nissle 1917 was investigated. Analysis of the growth capabilities of mutants altered for various components of the Csr system (csrA51, csrB, csrC and csrD mutations showed that only the protein CsrA - the key component of the system - exerts a marked role in carbon nutrition. Attenuation of CsrA activity in the csrA51 mutant affects the growth efficiency on a broad range of physiologically relevant carbon sources, including compounds utilized by the Entner-Doudoroff (ED pathway. Detailed investigations of the metabolomes and fluxomes of mutants and wild-type cells grown on carbon sources representative of glycolysis and of the ED pathway (glucose and gluconate, respectively, revealed significant re-adjusting of central carbon metabolism for both compounds in the csrA51 mutant. However, the metabolic re-adjusting observed on gluconate was strikingly different from that observed on glucose, indicating a nutrient-specific control of metabolism by the Csr system.

  9. The carbon storage regulator (Csr) system exerts a nutrient-specific control over central metabolism in Escherichia coli strain Nissle 1917.

    Science.gov (United States)

    Revelles, Olga; Millard, Pierre; Nougayrède, Jean-Philippe; Dobrindt, Ulrich; Oswald, Eric; Létisse, Fabien; Portais, Jean-Charles

    2013-01-01

    The role of the post-transcriptional carbon storage regulator (Csr) system in nutrient utilization and in the control of the central metabolism in E. coli reference commensal strain Nissle 1917 was investigated. Analysis of the growth capabilities of mutants altered for various components of the Csr system (csrA51, csrB, csrC and csrD mutations) showed that only the protein CsrA - the key component of the system - exerts a marked role in carbon nutrition. Attenuation of CsrA activity in the csrA51 mutant affects the growth efficiency on a broad range of physiologically relevant carbon sources, including compounds utilized by the Entner-Doudoroff (ED) pathway. Detailed investigations of the metabolomes and fluxomes of mutants and wild-type cells grown on carbon sources representative of glycolysis and of the ED pathway (glucose and gluconate, respectively), revealed significant re-adjusting of central carbon metabolism for both compounds in the csrA51 mutant. However, the metabolic re-adjusting observed on gluconate was strikingly different from that observed on glucose, indicating a nutrient-specific control of metabolism by the Csr system.

  10. Corporate Social Responsibility (CSR for Global Market Access: A Malaysian Case Study on Small and Medium Enterprises (SMEs

    Directory of Open Access Journals (Sweden)

    Tareq Bin Hossain

    2013-01-01

    Full Text Available The Corporate Social Responsibility (CSR is a powerful tool or channel for ensuring greater market access and enables a better engagement in the global market. The study examines how Corporate Social Responsibility (CSR is contributing to mass access of Small and Medium Enterprises (SMEs in the global market. The study used cross section primary data from the level of executives of the corporations. Towards the achievement of its objectives this study uses descriptive statistical tools. The findings of the study revealed that practicing of CSR is playing pivotal role to pick up the brand image and reputation of the Malaysian SMEs to the customers in the global arena.

  11. The moderating role of stakeholder pressure in the relationship between CSR practices and financial performance in a globalizing world

    DEFF Research Database (Denmark)

    Haleem, Fazli; Farooq, Sami; Boer, Harry;

    2015-01-01

    Studies based on the role of context and stakeholder pressures on the relationship between CSR practices and financial performance are few and inconclusive. Aimed at contributing to filling this gap, the paper is based on data collected in 2013 from the sixth round of the International...... Manufacturing Strategy Survey (IMSS-VI). Hierarchical regression is used to investigate three hypotheses on the relationships between CSR practices, financial performance and the influence of context and stakeholder pressures. The results show that CSR practices affect financial performance positively, while...... stakeholder pressures moderate this relationship....

  12. A Csr-type regulatory system, including small non-coding RNAs, regulates the global virulence regulator RovA of Yersinia pseudotuberculosis through RovM.

    Science.gov (United States)

    Heroven, Ann Kathrin; Böhme, Katja; Rohde, Manfred; Dersch, Petra

    2008-06-01

    The MarR-type regulator RovA controls expression of virulence genes of Yersinia pseudotuberculosis in response to environmental signals. Using a genetic strategy to discover components that influence rovA expression, we identified new regulatory factors with homology to components of the carbon storage regulator system (Csr). We showed that overexpression of a CsrB- or a CsrC-type RNA activates rovA, whereas a CsrA-like protein represses RovA synthesis. We further demonstrate that influence of the Csr system on rovA is indirect and occurs through control of the LysR regulator RovM, which inhibits rovA transcription. The CsrA protein had also a major influence on the motility of Yersinia, which was independent of RovM. The CsrB and CsrC RNAs are differentially expressed in Yersinia. CsrC is highly induced in complex but not in minimal media, indicating that medium-dependent rovM expression is mediated through CsrC. CsrB synthesis is generally very low. However, overexpression of the response regulator UvrY was found to activate CsrB production, which in turn represses CsrC synthesis independent of the growth medium. In summary, the post-transcriptional Csr-type components were shown to be key regulators in the co-ordinated environmental control of physiological processes and virulence factors, which are crucial for the initiation of Yersinia infections.

  13. Small RNAs targeting transcription start site induce heparanase silencing through interference with transcription initiation in human cancer cells.

    Directory of Open Access Journals (Sweden)

    Guosong Jiang

    Full Text Available Heparanase (HPA, an endo-h-D-glucuronidase that cleaves the heparan sulfate chain of heparan sulfate proteoglycans, is overexpressed in majority of human cancers. Recent evidence suggests that small interfering RNA (siRNA induces transcriptional gene silencing (TGS in human cells. In this study, transfection of siRNA against -9/+10 bp (siH3, but not -174/-155 bp (siH1 or -134/-115 bp (siH2 region relative to transcription start site (TSS locating at 101 bp upstream of the translation start site, resulted in TGS of heparanase in human prostate cancer, bladder cancer, and gastric cancer cells in a sequence-specific manner. Methylation-specific PCR and bisulfite sequencing revealed no DNA methylation of CpG islands within heparanase promoter in siH3-transfected cells. The TGS of heparanase did not involve changes of epigenetic markers histone H3 lysine 9 dimethylation (H3K9me2, histone H3 lysine 27 trimethylation (H3K27me3 or active chromatin marker acetylated histone H3 (AcH3. The regulation of alternative splicing was not involved in siH3-mediated TGS. Instead, siH3 interfered with transcription initiation via decreasing the binding of both RNA polymerase II and transcription factor II B (TFIIB, but not the binding of transcription factors Sp1 or early growth response 1, on the heparanase promoter. Moreover, Argonaute 1 and Argonaute 2 facilitated the decreased binding of RNA polymerase II and TFIIB on heparanase promoter, and were necessary in siH3-induced TGS of heparanase. Stable transfection of the short hairpin RNA construct targeting heparanase TSS (-9/+10 bp into cancer cells, resulted in decreased proliferation, invasion, metastasis and angiogenesis of cancer cells in vitro and in athymic mice models. These results suggest that small RNAs targeting TSS can induce TGS of heparanase via interference with transcription initiation, and significantly suppress the tumor growth, invasion, metastasis and angiogenesis of cancer cells.

  14. Standardized CSR and climate performance: why is Shell willing, but Hydro reluctant?; Shell; Hydro

    Energy Technology Data Exchange (ETDEWEB)

    Boasson, Elin Lerum; Wettestad, Joergen

    2007-06-15

    This report aims to contribute to the ongoing discussion concerning whether CSR merely serves to streamline company rhetoric or also has an influence on actual efforts. We discuss the tangible effects of CSR instruments on the climate-related rules and performances of the two different oil companies Hydro and Shell. First we explore whether similar CSR instruments lead to similar climate-related rules and practices in the two companies. Both Hydro and Shell adhere to the Global Compact (GC), the Global Reporting Initiative (GRI), the Carbon Disclosure Project (CDP) and the Global Gas Flaring Reduction Public-Private Partnership (GGFR). The report concludes that the GC has not rendered any tangible effects in either of the companies. Concerning the other instruments, Hydro has only followed the instrument requirements that fit their initial approach, and refrained from all deviating requirements. Shell has been more malleable, but we have noted few effects on the actual emissions and business portfolio resulting from the instrument adherence. Second, we assess how the differing results of the similar CSR portfolio may be explained. The reluctant attitude of the leaders in Hydro and the strong CSR motivation of Shell's executives result in significant differences. Hydro executives are able to constrain the effects of the instrument adherence. With Shell we note the opposite pattern: Its leaders promoted the instruments to be translated into internal rules, but a general lack of hierarchical structures hinders them from governing the conduct of various sub-organisations. The very diversity of the Shell culture helps to explain why the efforts of its executives have resulted in limited impact. The strength of the Hydro culture makes the corporation resistant to the instruments. Moreover, Hydro is strikingly shielded by virtue of its strong position in Norway. In contrast, Shell is more strongly affected by the global field of petroleum and the global field of CSR

  15. Effects of Core-Shell Rubber (CSR) Nanoparticles on the Fracture Toughness of an Epoxy Resin at Cryogenic Temperatures

    Science.gov (United States)

    Wang, J.; Cannon, S. A.; Schneider, J. A.

    2008-01-01

    This study investigates the effects of core-shell rubber (CSR) nanoparticles on the fracture toughness of an epoxy resin at liquid nitrogen (LN2) temperatures. Varying amounts of Kane Ace (Registered TradeMark) MX130 toughening agent were added to a commercially available EPON 862/W epoxy resin. Resulting fracture toughness was evaluated by the use of Charpy impact tests conducted on an instrumented drop tower. The size and distribution of the CSR nanoparticles were characterized using Transmission Electric Microscopy (TEM) and Small Angle X-ray Scattering (SAXS). Up to nominal 4.6% addition of the CSR nanoparticles, resulted in a nearly 5 times increase in the measured breaking energy. However, further increases in the amount of CSR nanoparticles had no appreciable affect on the breaking energy.

  16. Identifying Strategic Factors of the Implantation CSR in the Airline Industry: The Case of Asia-Pacific Airlines

    Directory of Open Access Journals (Sweden)

    Dong-Shang Chang

    2015-06-01

    Full Text Available Sustainable development has always been the objective of many fields, including the tourism and transportation sector. However, a major part of this sector, the airline industry, deals with many negative impacts, such as air pollution, noise, CO2 emission, and labor practice. Corporate social responsibility (CSR is a strategic business activity that can enhance the sustainability of the airline industry. The results of the Dow Jones Sustainability Indices (DJSI reveal that airlines of Western countries exhibit a more remarkable CSR performance than Asia-Pacific airlines, suggesting that the CSR programs of Asia-Pacific airlines need improvement. By constructing an evaluation hierarchy and applying the decision-making trial and evaluation laboratory (DEMATEL method, this study found that the key strategic factors in the airline industry’s implementation of CSR include corporate governance, risk and crisis management, brand management, and product responsibility (safety.

  17. The Impact of Supervisory Board Composition on CSR Reporting. Evidence from the German Two-Tier System

    Directory of Open Access Journals (Sweden)

    Dominik Dienes

    2016-01-01

    Full Text Available Corporate social responsibility (CSR reporting is becoming increasingly relevant in light of modern corporate governance. There is growing activity among empirical research in one-tier systems that considers the link between board composition and CSR reporting. This study is the first of its kind on the German two-tier system with special regard for the supervisory board. We analyze gender diversity, expertise, the presence of former managers, frequency of meetings, and the size of the supervisory board. Our multiple regressions indicate that gender diversity has a positive impact on CSR disclosure intensity, which is in line with prior studies on one-tier systems. Our findings have implications for both users and public policy and suggest that current European corporate governance regulations could help to increase the decision usefulness of CSR reporting.

  18. Squamous cell carcinoma of pancreas: an unusual site of relapse from early-stage lung cancer: 12-month postsurgery

    Science.gov (United States)

    Sharma, Anand; Alfa-Wali, Maryam; Rodriguez-Justo, Manuel; Polychronis, Andreas

    2013-01-01

    A 57-year-old man presented with abdominal pain and backache, weight loss of 10 kg and irregular bowel movements. He was previously diagnosed with Stage IB squamous cell carcinoma of lung and had undergone lobectomy 12 months previously. Investigations including imaging revealed a cystic mass in the body and tail of the pancreas which was biopsied and it was confirmed to be a recurrence of the squamous lung cancer involving the pancreas. He was treated with systemic chemotherapy and has shown a partial response on repeat imaging. This case illustrates a rare and unusual site of relapse in lung cancer after adjuvant therapy and a key message for follow-up surveillance for these patients. PMID:23608858

  19. RPORATE SOCIAL RESPONSIBILITY (CSR BIDANG LINGKUNGAN HIDUP PADA HOTEL BINTANG LIMA DI KAWASAN PARIWISATA UBUD, KABUPATEN GIANYAR

    Directory of Open Access Journals (Sweden)

    Olivia Grace Brigitta Florencia

    2016-12-01

    Full Text Available The negative impact of tourism accommodation development, is environmental damage. Law of the Republic of Indonesia No. 10 of 2009 on Tourism Article 26, requires owner to be responsible through environmental maintenance.Law of the Republic of Indonesia No. 40 of 2007 on Limited Liability Companies Article 74, requires each company to implement Corporate Social Responsibility (CSR.The ministry of Environment itself summarizes the CSR on environment, such as Production Profit, Eco Office, Waste Management with 3R principle (Reduce, Reuse and Recycle, Conservation of Natural Resources and Energy, Renewable Energy, Climate Change Adaptation and Environmental Education.This research aimed to analyze the effectivity of CSR programs on environmental in fivestar hotels in Ubud Region, the factors that affect the program, and its development strategy. The research used descriptive quantitative method. The method of data collection using observation, interviews, and questionnaires. Data obtained was analyzed using descriptive qualitative method, complemented with IFAS (Internal Factor Analysis Summary, EFAS (External Factor Analysis Summary, and SWOT analysis.The result showed that implementation of CSR programs has not entirely been done effectively. From seven CSR programs, two programs have been categorized effective. Those two programs are Climate Change Adaptation and Environmental Education. However the program which has not run effectively is Production Profit, Eco Office, Waste Management with 3R principle (Reduce, Reuse and Recycle, Conservation of Natural Resources and Energy Renewable Energy. The main factor affecting CSR Program is organization, with score of 4.41. CSR implementation strategy, the manager continues the previous strategy that has been done. However, for the advancement of CSR programs is necessary needed revamping management, with concentration via vertical integration.

  20. Corporate Brand Trust as a Mediator in the Relationship between Consumer Perception of CSR, Corporate Hypocrisy, and Corporate Reputation

    OpenAIRE

    Hanna Kim; Won-Moo Hur; Junsang Yeo

    2015-01-01

    The aim of this research is to investigate the relationship between consumer perception of Corporate Social Responsibility (CSR), corporate brand trust, corporate hypocrisy, and corporate reputation. Based on the one-to-one interview method using a structured questionnaire of 560 consumers in South Korea, the proposed model was estimated by structural equation modeling analysis. The model suggests that consumer perception of CSR influences consumer attitudes toward a corporation ( i.e. , perc...

  1. Driving corporate social responsibility (CSR) through the companies act: an overview of the role of the social and ethics committee

    OpenAIRE

    2013-01-01

    The corporate social responsibility (CSR) movement can be described as a bundle of trends comprising regulatory frameworks aimed at improving corporate practices and leading to changes in these practices, the mobilisation of corporate role players to support the development of states, and a management trend the purpose of which is to enhance the legitimacy of a business. Government is regarded as one of the most important driving forces behind the CSR agenda and it has a partic...

  2. CREATING COMPETITIVE ADVANTAGES – THE EUROPEAN CSR-STRATEGY COMPARED WITH PORTER'S AND KRAMER'S SHARED VALUE APPROACH

    OpenAIRE

    Regina Moczadlo

    2015-01-01

    In 2011 the European Commission changed the definition and strategy for corporate social responsibility (CSR) with the creation of shared value as one core element of the new concept. In the same year Porter and Kramer published in the Harvard Business Review their approach of creating shared value (CSV) as core element of long-term business strategies. The starting point of both approaches is the societal legitimation of enterprises to do business. CSR respective CSV are evaluated to be a me...

  3. Creating shared value through business models based on sustainability and CSR : An empirical study of Swedish companies

    OpenAIRE

    Haskell, Lucas; Pålhed, Johan

    2016-01-01

    Businesses and humans in general have led to a variety of different social and environmental problems. In this thesis we call on businesses to be the solution to these problems. Therefore, we have developed two research questions:   How do Swedish companies incorporate CSR and sustainability into their business models? and How do Swedish companies create shared value through business models based on sustainability and CSR?   The purpose of these research questions is to discover how Swedish c...

  4. Relation between primary tumor FDG avidity and site of first distant metastasis in patients with breast cancer.

    Science.gov (United States)

    Lim, Chae Hong; Moon, Seung Hwan; Cho, Young Seok; Im, Young-Hyuck; Choe, Yearn Seong; Kim, Byung-Tae; Lee, Kyung-Han

    2016-08-01

    Identification of tumor imaging features associated with metastatic pattern may allow better understanding of cancer dissemination. Here, we investigated how primary tumor F-fluorodeoxyglucose (FDG) avidity influences the first site of breast cancer metastasis.Subjects were 264 patients with advanced breast cancer who underwent positron emission tomography/computed tomography at diagnosis and had metastasis at presentation (n = 193) or metastatic relapse after surgery (n = 71). Primary tumor FDG avidity (maximum SUV [SUVmax] ≥10.1) was compared with histology and first metastatic sites.The most common site of first metastasis was the bone, occurring in 62.7% of patients with metastasis at presentation and 38.0% of those with metastatic relapse. First metastasis to lung occurred in 30.1% and 35.2%, and to liver in 25.4% and 15.2% of respective groups. In patients with metastasis at presentation, primary tumors were FDG avid in 98/193 cases, and this was associated with more frequent first metastasis to lung (37.8% vs 22.1%; P = 0.018). In patients with metastasis relapse, primary tumors were FDG avid in 31/71 cases, and this was associated with more frequent first metastasis to lung (48.4% vs 25.0%; P = 0.041) and liver (29.0% vs 5.0%; P = 0.008). In patients with metastasis relapse, primary tumors that were FDG avid but hormone receptor negative had more first metastasis to lung (57.9% vs 26.9%; P = 0.016).FDG-avid primary breast tumors have favored first spread to the lung and liver, which suggests that tumor cells with heightened glycolytic activity better colonize these organs.

  5. The Trend of CSR Disclosures and the Role of Corporate Governance Attributes: The Case of Shari'ah Compliant Companies in Malaysia

    Directory of Open Access Journals (Sweden)

    Abdifatah Ahmed Haji

    2012-12-01

    Full Text Available This study examines the trend of corporate social responsibility (CSR disclosures and the role of corporate governance attributes in the CSR disclosures of Shari’ah compliant companies (ShCCs in Malaysia for the years 2006 and 2009, a period which corresponds before and after a plethora of significant changes in Malaysia, encompassing the recent financial crisis and policy changes in the form of corporate governance restructuring. Using a CSR disclosure checklist, the extent and quality of CSR discourses of a sample of 76 ShCCs was examined. The results indicate that the extent and quality of CSR disclosures by the ShCCs is in overall low. However, there was a significant increasing trend in both the extent and quality of the CSR disclosures by the ShCCs over time. results of this study offer a number of practical implications. First, whilst the findings reveal a significant increasing trend of CSR information subsequent to the policy changes and the recent financial crisis, the CSR information was however not systematically provided, with most of the disclosures being stated in a narrative form. Hence, the policy makers in Malaysia may want to re-enforce the mandatory requirement of CSR information and provide a detailed CSR framework for the companies to follow such as "what" and "how" the CSR information should be disclosed. Second, the role of corporate governance attributes in the social disclosures of the ShCCs did not improve following the revised code, perhaps due to the unfolding recent global financial turmoil which may have undermined the effectiveness of the corporate governance attributes. Finally, this study offers the first empirical study to have assessed the trend of CSR disclosures and the role of governance attributes in CSR disclosure practices by the ShCCs.

  6. Multimodal aspects of CSR communication related to gender empowerment and environmental protection

    DEFF Research Database (Denmark)

    Maier, Carmen Daniela

    Purpose – This paper explores how the multimodal persuasive strategies of CSR communication related to Coca-Cola’s “5 by 20” succeed to highlight the company’s continuous commitment to gender empowerment and environmental protection. Launched in 2010, “5 by 20” is a program designed to empower 5...... and communities due to the implementation of this program. The environmental concerns are embedded in their activities. Approach – Drawing on an interdisciplinary methodological framework related to CSR communication, multimodal discourse analysis, gender theory and environmental communication, the paper proposes...... of actors, actions, space and time. Findings – The paper explains how the commitment for gender empowerment and environmental protection is communicated through a complex interplay of several semiotic modes. It claims that by exploring how these semiotic modes reinforce, complement or subvert each other...

  7. Role of corporate social responsibility (CSR in business planning and practice of Croatian companies

    Directory of Open Access Journals (Sweden)

    Nidžara Osmanagić Bedenik

    2011-12-01

    Full Text Available The main objective of this paper is to examine business, social and ecological dimensions of the entrepreneurial activities of small, medium and large enterprises in Croatia by comparing different levels of acceptance, incorporation and utilization of those dimensions among the surveyed companies. Our purpose is to empirically identify and assess the attitudes with regard to as well as the importance and priorities of CSR aspects in business planning. This research provides findings on the priorities and characteristics of CSR concepts of the surveyed enterprises. Based on the empirical results of this study, they can be said to be focused on the operational and financial business aspects. Simultaneously, there is a constant awareness of the necessity for a business change and of the importance of broadening the perspectives to a strategic and normative dimension.

  8. The status and improvement of the HIRFL-CSR operation software

    Science.gov (United States)

    Li, Peng; Yuan, Y. J.; Yang, J. C.; Xia, J. W.; Zhang, W.; Mao, R. S.; Yin, D. Y.; Chai, W. P.

    2013-01-01

    HIRFL-CSR is a new ion cooler-storage ring system in China's Institute of Modern Physics (IMP). This facility can accelerate all ions from protons up to the heaviest element, uranium, with variable energies for nuclear physics experiments, material irradiation research, and heavy ion particle therapy and so on. With the completion of this project, a new accelerator control system has been developed to accomplish the beam injection, accumulation, acceleration, extraction and manipulation. In this paper, the architectures of the HIRFL-CSR control system and timing system, the basic function of operation software, the data cycles of power supplies and the RF cavity are described in detail. Furthermore, to fulfill the requirements of special physics experiments and enhance the facility reliability, several operation software improvements, including eliminating the magnetic hysteresis effects, dipole magnets field slow feedback and super-period slow extraction, are also introduced in this paper.

  9. Community in Credit Unions: Has banking regulationimpaired CSR in Australian Customer Owned Banks?

    Directory of Open Access Journals (Sweden)

    Dianne McGrath

    2017-02-01

    Full Text Available This paper presents a sector scan of a sample of Australian Credit Unions and Mutual Banks to examine the CSR reporting from the perspective of the three pillars model proposed by vanOorschot, de Hoog, van der Steen and van Twist (2013. It is argued that the pillar requiringco-operatives to ensure activities which ‘aim for change’, should promote increasing adoptionof CSR. The paper theorises that regulatory requirements imposed in Australia on all bankinginstitutions carry a higher proportional cost to the customer owned banking sector than theshareholder based commercial banks. This consumption of the limited financial resourcesavailable in this sector of banking services, are inhibiting regional Customer Owned Bankingproviders, as co-operative organisations, to fulfil the required co-operative principle to instigatechange for the betterment of communities. This failure could signal the demise of some entitiesin the jurisdiction of Customer Owned Banking.

  10. Capitalising on CSR-based partnerships in sports branding and sports sponsorship

    DEFF Research Database (Denmark)

    Cortsen, Kenneth Holm

    2014-01-01

    . Inspired by Shank's (2009) notion of the sports brand building process, i.e.: 1) brand awareness; 2) brand image; 3) brand equity; 4) brand loyalty, the interacting nature of sports brands exemplified by how sports brands at the corporate level interact with sports brands at the personal and product levels......The purpose of this article is to develop a toolkit for academics and practitioners, which elaborates on how strategic application of corporate social responsibility (CSR) may guide sports branding initiatives and sponsorship partnerships and lead to increased levels of brand capitalisation...... is integrated in the article. This is done to propose how these interactions may increase the effect of the work with strategic CSR on corporate sports brands....

  11. CSR induced microbunching gain estimation including transient effects in transport and recirculation arcs

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, Cheng [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Jefferson Lab., Newport News, VA (United States); Douglas, David R. [Jefferson Lab., Newport News, VA (United States); Li, Rui [Jefferson Lab., Newport News, VA (United States)

    2015-09-01

    The coherent synchrotron radiation (CSR) of a high brightness electron beam traversing a series of dipoles, such as transport or recirculation arcs, may result in the microbunching instability (μBI). To accurately quantify the direct consequence of this effect, we further extend our previously developed semi-analytical Vlasov solver to include more relevant coherent radiation models than the steady-state free-space CSR impedance, such as the entrance and exit transient effects derived from upstream beam entering to and exiting from individual dipoles. The resultant microbunching gain functions and spectra for our example lattices are presented and compared with particle tracking simulation. Some underlying physics with inclusion of these effects are also discussed.

  12. CSR induced microbunching gain estimation including transient effects in transport and recirculation arcs

    CERN Document Server

    Tsai, Cheng-Ying; Li, Rui; Tennant, Chris

    2015-01-01

    The coherent synchrotron radiation (CSR) of a high brightness electron beam traversing a series of dipoles, such as transport or recirculation arcs, may result in the microbunching instability ({\\mu}BI). To accurately quantify the direct consequence of this effect, we further extend our previously developed semi-analytical Vlasov solver [C. -Y. Tsai et al., FEL Conference 2014 (THP022)] to include more relevant coherent radiation models than the steady-state free-space CSR impedance, such as the entrance and exit transient effects derived from upstream beam entering to and exiting from individual dipoles. The resultant microbunching gain functions and spectra for our example lattices are presented and compared with particle tracking simulation. Some underlying physics with inclusion of these effects are also discussed.

  13. Capitalising on CSR-based partnerships in sports branding and sports sponsorship

    DEFF Research Database (Denmark)

    Cortsen, Kenneth

    2014-01-01

    The purpose of this article is to develop a toolkit for academics and practitioners, which elaborates on how strategic application of corporate social responsibility (CSR) may guide sports branding initiatives and sponsorship partnerships and lead to increased levels of brand capitalisation...... is integrated in the article. This is done to propose how these interactions may increase the effect of the work with strategic CSR on corporate sports brands........ Inspired by Shank's (2009) notion of the sports brand building process, i.e.: 1) brand awareness; 2) brand image; 3) brand equity; 4) brand loyalty, the interacting nature of sports brands exemplified by how sports brands at the corporate level interact with sports brands at the personal and product levels...

  14. Cancer-associated mutations are preferentially distributed in protein kinase functional sites.

    Science.gov (United States)

    Izarzugaza, Jose M G; Redfern, Oliver C; Orengo, Christine A; Valencia, Alfonso

    2009-12-01

    Protein kinases are a superfamily involved in many crucial cellular processes, including signal transmission and regulation of cell cycle. As a consequence of this role, kinases have been reported to be associated with many types of cancer and are considered as potential therapeutic targets. We analyzed the distribution of pathogenic somatic point mutations (drivers) in the protein kinase superfamily with respect to their location in the protein, such as in structural, evolutionary, and functionally relevant regions. We find these driver mutations are more clearly associated with key protein features than other somatic mutations (passengers) that have not been directly linked to tumor progression. This observation fits well with the expected implication of the alterations in protein kinase function in cancer pathogenicity. To explain the relevance of the detected association of cancer driver mutations at the molecular level in the human kinome, we compare these with genetically inherited mutations (SNPs). We find that the subset of nonsynonymous SNPs that are associated to disease, but sufficiently mild to the point of being widespread in the population, tend to avoid those key protein regions, where they could be more detrimental for protein function. This tendency contrasts with the one detected for cancer associated-driver-mutations, which seems to be more directly implicated in the alteration of protein function. The detailed analysis of protein kinase groups and a number of relevant examples, confirm the relation between cancer associated-driver-mutations and key regions for protein kinase structure and function.

  15. Corporate Brand Trust as a Mediator in the Relationship between Consumer Perception of CSR, Corporate Hypocrisy, and Corporate Reputation

    Directory of Open Access Journals (Sweden)

    Hanna Kim

    2015-03-01

    Full Text Available The aim of this research is to investigate the relationship between consumer perception of Corporate Social Responsibility (CSR, corporate brand trust, corporate hypocrisy, and corporate reputation. Based on the one-to-one interview method using a structured questionnaire of 560 consumers in South Korea, the proposed model was estimated by structural equation modeling analysis. The model suggests that consumer perception of CSR influences consumer attitudes toward a corporation (i.e., perceived corporate hypocrisy and corporate reputation by developing corporate brand trust. This in turn further enhances corporate reputation while decreasing corporate hypocrisy. The findings of our study demonstrate that consumer perception of CSR is an antecedent to corporate brand trust, which fully mediates the relationship between consumer perception of CSR and corporate reputation. In addition, corporate brand trust has the role of partial mediator in the relationship between consumer perception of CSR and corporate hypocrisy. These results imply that to better understand the relationship between consumer perception of CSR and consumer attitudes toward a corporation, it is necessary to consider corporate brand trust as an important mediating variable. The theoretical and practical implications of this study are discussed, together with its limitations and potential for future research.

  16. State-driven Corporate Social Responsibility? Mediating Offshore Outsourcing and CSR in Malaysia

    OpenAIRE

    Chong, Sabrina; Wad, Peter

    2008-01-01

    Offshore outsourcing of business activities from the Global North to the Global South does not only relocate investments and jobs, but has also brought about new business demands on suppliers activities and their social and environmental impact. The article explores whether, how and why offshore outsourcing transactions between foreign firms and Malaysian firms affect the upgrading of the CSR activities of Malaysia incorporated firms, taking the particular institutional context of Malaysia in...

  17. Modeling Employee Satisfaction in Relation to CSR Practices and Attraction and Retention of Top Talent

    OpenAIRE

    Simona VINEREAN; CETINA Iuliana; Luigi DUMITRESCU

    2013-01-01

    In today’s economy, companies must work harder than ever to attract, retain and motivate talented employees in order to foster employee satisfaction, and in order to do so, CSR practices can provide a strategic tool. A green company no longer denotes solely the promotion of green products or reduction of energy consumption, as it has to incorporate proactive and innovative means of tracking sustainability while involving employees in such corporate behavior. This paper highlights an empirical...

  18. Advertising to bottom of the pyramid consumers: descriptive analysis of CSR advertising

    OpenAIRE

    Rahman, Mizan

    2014-01-01

    The paper aims to understand through primary research the effectiveness of advertising where corporate social responsibility (CSR) messages are given in an international marketing context in a developing country. The work would benefit marketers devise their international marketing strategy and would give new insights into positioning a brand strategically in the developing world. The discussion is on the practice of Telenor, a Norwegian telecommunications company in Bangladesh, a South East ...

  19. Suppression of the emittance growth induced by CSR in a DBA cell

    CERN Document Server

    Xiao-Hao, Cui; Gang, Xu; Xi-Yang, Huang

    2013-01-01

    The Emittace growth induced by Coherent Synchrotron Radiation(CSR) is an important issue when electron bunches with short bunch length and high peak current are transported in a bending magnet. In this paper, a single kick method is introduced which could give the same result as the R-matrix method, and much easier to use. Then with this method, an optics design technique which could minimize the emittance dilution within a single achromatic cell.

  20. Student Lloyd C. Bruce listens to MS John M. Lounge in CSR during STS-26

    Science.gov (United States)

    1988-01-01

    Seated in the customer support room (CSR) of JSC's Mission Control Center (MCC) Bldg 30, student experimenter Lloyd C. Bruce listens to Mission Specialist (MS) John M. Lounge onboard Discovery, Orbiter Vehicle (OV) 103, during the STS-26 mission. Bruce's student experiment 82-4 (SE82-4) 'The Effects of Weightlessness on Grain Formation and Strength in Metals' is onboard OV-103. Lounge is visible in the television (TV) monitor on the left.

  1. CSR 2.0 and the new era of corporate citizenship

    OpenAIRE

    Camilleri, Mark Anthony

    2017-01-01

    Why should you choose this book? This publication is primarily intended to academia, including post graduate students pursuing research degrees. It explores the core aspects of contemporary corporate strategies, public policies and practices that create value. This publication is a concise and authoritative guide on the business case for corporate social responsibility (CSR). It provides a thorough understanding on the theoretical underpinnings of corporate social responsibility, business ...

  2. Cancer and Asians/Pacific Islanders

    Science.gov (United States)

    ... Liver & IBD* 6.0 3.1 1.9 Stomach 4.4 1.8 2.4 Breast 11.2 21.5 0.5 *IBD = Intrahepatic Bile Duct Source: NCI 2016. Seer Cancer Statistics Review, 1975-2013. Table 1.21. http://seer.cancer.gov/csr/2013/sections.html Screening Breast Cancer Percent of women age 40 and ...

  3. A STUDY CASE ON CSR AND MANAGERIAL CULTURE IN THE EASTERN ROMANIAN PRIVATE BUSINESS

    Directory of Open Access Journals (Sweden)

    Roxana Mironescu

    2016-07-01

    Full Text Available The Corporate Social Responsibility (CSR is a prerequisite for business growth, through innovation and business opportunities providing, in order to make the difference between companies, in the high competitive environment. In our view, the CSR must be integrated and developed inside the company strategy, as its basic set of moral values and principles that reflect the company goals. In this scientific approach, we have explained the concept of Social Responsibility both in terms of theory and as an analysis support for practical issues, in some eastern Romanian companies. The paper is oriented for achieving two main goals: to determine the main Social Responsibility actions made by the companies and to demonstrate the importance of their implementation; to explore the impact of the CSR activities on an expected advantageous position of these companies on their markets. Considered as a direct beneficiary of the community where it belongs, the company returns a part of its success to the community through its active participation in the critical general problems. A company that does not respect the environment, the community, its employees or the ethical principles, will lose credibility and will move away customers and suppliers.

  4. The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression.

    Science.gov (United States)

    Seth, Meetu; Shirayama, Masaki; Gu, Weifeng; Ishidate, Takao; Conte, Darryl; Mello, Craig C

    2013-12-23

    Organisms can develop adaptive sequence-specific immunity by reexpressing pathogen-specific small RNAs that guide gene silencing. For example, the C. elegans PIWI-Argonaute/piwi-interacting RNA (piRNA) pathway recruits RNA-dependent RNA polymerase (RdRP) to foreign sequences to amplify a transgenerational small-RNA-induced epigenetic silencing signal (termed RNAe). Here, we provide evidence that, in addition to an adaptive memory of silenced sequences, C. elegans can also develop an opposing adaptive memory of expressed/self-mRNAs. We refer to this mechanism, which can prevent or reverse RNAe, as RNA-induced epigenetic gene activation (RNAa). We show that CSR-1, which engages RdRP-amplified small RNAs complementary to germline-expressed mRNAs, is required for RNAa. We show that a transgene with RNAa activity also exhibits accumulation of cognate CSR-1 small RNAs. Our findings suggest that C. elegans adaptively acquires and maintains a transgenerational CSR-1 memory that recognizes and protects self-mRNAs, allowing piRNAs to recognize foreign sequences innately, without the need for prior exposure

  5. A multitasking Argonaute: exploring the many facets of C. elegans CSR-1.

    Science.gov (United States)

    Wedeles, Christopher J; Wu, Monica Z; Claycomb, Julie M

    2013-12-01

    While initial studies of small RNA-mediated gene regulatory pathways focused on the cytoplasmic functions of such pathways, identifying roles for Argonaute/small RNA pathways in modulating chromatin and organizing the genome has become a topic of intense research in recent years. Nuclear regulatory mechanisms for Argonaute/small RNA pathways appear to be widespread, in organisms ranging from plants to fission yeast, Caenorhabditis elegans to humans. As the effectors of small RNA-mediated gene regulatory pathways, Argonaute proteins guide the chromatin-directed activities of these pathways. Of particular interest is the C. elegans Argonaute, chromosome segregation and RNAi deficient (CSR-1), which has been implicated in such diverse functions as organizing the holocentromeres of worm chromosomes, modulating germline chromatin, protecting the genome from foreign nucleic acid, regulating histone levels, executing RNAi, and inhibiting translation in conjunction with Pumilio proteins. CSR-1 interacts with small RNAs known as 22G-RNAs, which have complementarity to 25 % of the protein coding genes. This peculiar Argonaute is the only essential C. elegans Argonaute out of 24 family members in total. Here, we summarize the current understanding of CSR-1 functions in the worm, with emphasis on the chromatin-directed activities of this ever-intriguing Argonaute.

  6. Effects of CSR Generated from Upstream Bends in a Laser Plasma Storage Ring

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, C.; Qiang, J.; Venturini, M.

    2013-08-28

    The recent proposal [1] of a Laser Plasma Storage Ring (LPSR) envisions the use of a laser-plasma (LP) acceleration module to inject an electron beam into a compact 500 MeV storage ring. Electron bunches generated by LP methods are naturally very short (tens of femtoseconds), presenting peak currents on the order of 10 kA or higher. Of obvious concern is the impact of collective effects and in particular Coherent Synchrotron Radiation (CSR) on the beam dynamics in the storage ring. Available simulation codes (e.g. Elegant [2]) usually include transient CSR effects but neglect the contribution of radiation emitted from trailing magnets. In a compact storage ring, with dipole magnets close to each other, cross talking between different magnets could in principle be important.In this note we investigate this effect for the proposed LPSR and show that, in fact, this effect is relatively small. However our analysis also indicates that CSR effects in general would be quite strong and deserve a a careful study.

  7. 超临界水冷堆CSR1000流动不稳定性研究%Flow Instability Analysis of Supercritical Water-Cooled Reactor CSR1000 based on Frequency Domain

    Institute of Scientific and Technical Information of China (English)

    田文喜; 田晓艳; 冯健; 秋穗正; 苏光辉; 鲁剑超

    2013-01-01

    Flow instability of Supercritical Water-cooled Reactor CSR1000 was studied and mathematics model of core in supercritical water-cooled reactor CSR 1000 was established.A code named FREDO-CSR1000(Frequency domain analysis of CSR1000) and a code named TIMDO(Time-Domain Method) have been developed to analyze the flow instability of Supercritical Water-cooled Reactor CSR1000 after the codes was verified.The results show that the shape of stability map obtained by the two different methods are very similar, both of which are divided into two regions, respectively corresponding to two types of flow instability, namely the flow drift and the density wave oscillation instability.Besides, it is also found that the operation points of CSR1000 calculated by the frequency domain method and time domain method are both in the safety operation region., which are far away from the unstable region.%针对中国超临界水冷堆(CSR1000)建立堆芯数学模型,开发基于频域法的超临界水冷堆流动不稳定性分析程序FREDO-CSR1000和基于时域法的超临界水冷堆流动不稳定性分析程序TIMDO.对程序进行初步验证后,使用其对CSR1000堆芯进行流动不稳定性分析计算,计算结果显示由频域法和时域法计算得到的稳定性边界图都明显分成2个区域,呈现倾斜的双L型,明显存在2个拐点,分别对应流量漂移和密度波振荡2种流动不稳定性现象.2种方法计算得到的CSR1000运行点都处于安全运行空间内,距离流动不稳定性边界较远.

  8. DRIVING CORPORATE SOCIAL RESPONSIBILITY (CSR THROUGH THE COMPANIES ACT: AN OVERVIEW OF THE ROLE OF THE SOCIAL AND ETHICS COMMITTEE

    Directory of Open Access Journals (Sweden)

    Henk J Kloppers

    2013-04-01

    Full Text Available The corporate social responsibility (CSR movement can be described as a bundle of trends comprising regulatory frameworks aimed at improving corporate practices and leading to changes in these practices, the mobilisation of corporate role players to support the development of states, and a management trend the purpose of which is to enhance the legitimacy of a business. Government is regarded as one of the most important driving forces behind the CSR agenda and it has a particularly important role to play in the creation of an enabling CSR environment.In general, advocates of legislative involvement in framing the CSR policy highlight the failure of existing voluntary systems as one of the main reasons why the state should play a more important role in the facilitation of CSR. Although governments realise the importance of encouraging socially responsible business, it should be noted that CSR should not replace regulation or legislation concerning social rights. Furthermore CSR should not be seen as shifting (or outsourcing the state's responsibility for the provision of basic services (such as education or the provision of health services to the private sector and thus "privatising" the state's responsibilities. However, the legacies of apartheid remain firmly entrenched in the social problems facing South Africa and it seems as if the Government is unable to deliver the social and physical infrastructure required to effect the desired transformation, thus necessitating the engagement of the private sector. The role of Government in establishing a CSR policy framework and driving CSR has become increasingly important. The (perceived failure of the welfare state has given further impetus to the move of governments toward tapping into the resources of the private sector (through their CSR in order to address socio-economic challenges. A purely voluntary approach to CSR without any legislative intervention will not succeed – a clear public

  9. Paper Highlight: Biomarker Identified for Predicting Early Prostate Cancer Aggressiveness — Site

    Science.gov (United States)

    A team led by Cory Abate-Shen, Michael Shen, and Andrea Califano at Columbia University found that measuring the expression levels of three genes associated with aging can be used to predict the aggressiveness of seemingly low-risk prostate cancer.

  10. Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type–specific cancer genes in leukemia

    Science.gov (United States)

    Sauvageau, Martin; Miller, Michelle; Lemieux, Sébastien; Lessard, Julie; Hébert, Josée; Sauvageau, Guy

    2017-01-01

    Proviral insertional mutagenesis is a powerful tool for the discovery of cancer-associated genes. The ability of integrated proviruses to affect gene expression over long distances combined with the lack of methods to determine the expression levels of large numbers of genes in a systematic and truly quantitative manner have limited the identification of cancer genes by proviral insertional mutagenesis. Here, we have characterized a new model of proviral insertional mutagenesis-induced lymphoid tumors derived from Eed Polycomb group gene mutant mice and quantitatively determined the expression levels of all genes within 100 kb of 20 different retroviral common insertion sites (CISs) identified in these tumors. Using high-throughput quantitative reverse transcription–polymerase chain reaction (Q-RT-PCR), we document an average of 13 CIS-associated genes deregulated per tumor, half of which are leukemia subtype–specific, while the others are coordinately deregulated in the majority of tumors analyzed. Interestingly, we find that genes located distantly from common proviral integration sites are as frequently deregulated as proximal genes, with multiple genes affected per integration. Our studies reveal an unsuspected conservation in the group of genes deregulated among phenotypically similar subtypes of lymphoid leukemias, and suggest that identification of common molecular determinants of this disease is within reach. PMID:17906077

  11. Sanctuary site leptomeningeal metastases in HER-2 positive breast cancer: A review in the era of trastuzumab.

    Science.gov (United States)

    Kordbacheh, T; Law, W Y; Smith, I E

    2016-04-01

    The development of trastuzumab and other targeted systemic therapies has transformed the management of HER-2 positive breast cancers. However, as patients live longer and systemic therapies may not cross the blood brain barrier a rising number of patients are developing leptomeningeal metastases and brain metastases as a sanctuary site of disease. Intrathecal trastuzumab has been reported to treat these. We describe a breast cancer patient with HER-2 positive leptomeningeal disease in the spinal cord successfully treated with intrathecal trastuzumab and methotrexate, alongside systemic anti-HER-2 therapy and radiotherapy. We also review the literature to date on the efficacy and safety of intrathecal trastuzumab, and recent evidence suggesting that intrathecal trastuzumab passes via the blood brain barrier into the serum to achieve intravenous concentrations similar to that seen with systemic therapy alone. Overall, intrathecal trastuzumab appears to be a safe and often effective treatment for leptomeningeal metastases in HER-2 positive breast cancer. Ongoing phase I and II studies are required to determine optimum dosing schedules, validate CSF and CSF-to-serum pharmacokinetics, determine efficacy, and to assess the added benefits or disadvantages of prior radiotherapy and concomitant systemic therapy.

  12. Internal Mammary Recipient Site Breast Cancer Recurrence Following Delayed Microvascular Breast Reconstruction

    OpenAIRE

    Rosich-Medina, Anais; Wang, Susan; Erel, Ertan; Malata, Charles M.

    2013-01-01

    Objective: The internal mammary vessels are a popular recipient site for microsurgical anastomoses of free flap breast reconstructions. We, however, observed 3 patients undergoing internal mammary vessel delayed free flap breast reconstruction that subsequently developed tumor recurrence at this site. We reviewed their characteristics to determine whether there was a correlation between delayed microsurgical reconstruction and local recurrence. Methods: A retrospective review of a single surg...

  13. Investigators' - Site Coordinators' Opportunity for Research Excellence (I-SCORE) Workshop | Division of Cancer Prevention

    Science.gov (United States)

    The DCP Organ Systems Research Groups develop, support and oversee clinical cancer prevention trials and promote participation by all populations. The trials are designed to evaluate the safety and efficacy of promising new preventive agents, the utility of novel biomarkers and the value of innovative technologies to identify premalignant lesions. The Consortia for Early Phase Prevention Trials program was created to facilitate the efficient implementation of these studies by teams of multidisciplinary investigators. |

  14. Cancer and birth defects surveillance system for communities around the Savannah River Site. Annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Dunbar, J.B.

    1994-05-01

    The US DOE funded this grant to the Medical University of South Carolina for a cancer and birth defects registry for an initial three year period which was completed as of April 29, 1994. While this Technical Progress Report is prepared principally to document the activities of year 03, it also summarizes the accomplishments of the first two years in order to put into perspective the energy and progress of the program over the entire three year funding cycle.

  15. A cellular stress response (CSR) that interacts with NADPH-P450 reductase (NPR) is a new regulator of hypoxic response.

    Science.gov (United States)

    Oguro, Ami; Koyama, Chika; Xu, Jing; Imaoka, Susumu

    2014-02-28

    NADPH-P450 reductase (NPR) was previously found to contribute to the hypoxic response of cells, but the mechanism was not clarified. In this study, we identified a cellular stress response (CSR) as a new factor interacting with NPR by a yeast two-hybrid system. Overexpression of CSR enhanced the induction of erythropoietin and hypoxia response element (HRE) activity under hypoxia in human hepatocarcinoma cell lines (Hep3B), while knockdown of CSR suppressed them. This new finding regarding the interaction of NPR with CSR provides insight into the function of NPR in hypoxic response.

  16. 产品伤害危机后企业社会责任的选择:商业型还是慈善型%CSR Selection after the Crises about Harm to Products:Business CSR or Philanthropic CSR

    Institute of Scientific and Technical Information of China (English)

    王汉瑛; 田虹

    2016-01-01

    产品伤害危机发生后,很多企业积极开展社会责任活动来修复已经受损的企业形象,然而选择不同的企业社会责任(CSR)策略可能产生完全不同的效果。针对这一问题,文章从利益相关者理论工具性视角和规范性视角的矛盾出发,引入认知失调理论和归因理论的观点,构建了一个综合性理论模型以使这两种视角的矛盾观点达成和解。实验结果表明,在中国当前有限信任和信息不对称环境中,消费者怀疑在企业社会责任感知和购买意向改变中起到中介作用;并且商业型CSR和慈善型CSR的交互作用可以通过影响消费者怀疑来影响消费者购买意向的改变;只有当商业型CSR较高时,慈善型CSR才会起到积极作用;否则投入较多的慈善型CSR更容易引发消费者的怀疑。因此,实践中企业应当在资源充足的情况下选择双高型CSR策略;在资源不足的情况下选择商业型CSR高、慈善型CSR低的策略。研究明确了消费者对CSR活动进行解读与反馈的心理机制,从而帮助企业走出产品伤害危机后CSR修复策略的实践困境。%Many corporations implement CSR activities after the crises about harm to products to restore damaged firm images .However ,different CSR selections may have completely differ‐ent effects .Drawing on the conflict of instrumental and normative views of stakeholder theory , this paper introduces both cognitive dissonance theory and attribution theory to build a compre‐hensive theoretical model to reconcile the conflict between the two views .Experimental results show that in current environment of limited trust and asymmetric information in China ,consum‐er suspicion plays an intermediary role in CSR perception and the change in purchase intentions . The interactive effect of business CSR and philanthropic CSR affects the changes in consumer purchase intentions through consumer suspicion .Moreover

  17. Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites

    Directory of Open Access Journals (Sweden)

    Pierce Levi CT

    2009-01-01

    Full Text Available Abstract Background Gene rearrangements such as chromosomal translocations have been shown to contribute to cancer development. Human chromosomal fragile sites are regions of the genome especially prone to breakage, and have been implicated in various chromosome abnormalities found in cancer. However, there has been no comprehensive and quantitative examination of the location of fragile sites in relation to all chromosomal aberrations. Results Using up-to-date databases containing all cancer-specific recurrent translocations, we have examined 444 unique pairs of genes involved in these translocations to determine the correlation of translocation breakpoints and fragile sites in the gene pairs. We found that over half (52% of translocation breakpoints in at least one gene of these gene pairs are mapped to fragile sites. Among these, we examined the DNA sequences within and flanking three randomly selected pairs of translocation-prone genes, and found that they exhibit characteristic features of fragile DNA, with frequent AT-rich flexibility islands and the potential of forming highly stable secondary structures. Conclusion Our study is the first to examine gene pairs involved in all recurrent chromosomal translocations observed in tumor cells, and to correlate the location of more than half of breakpoints to positions of known fragile sites. These results provide strong evidence to support a causative role for fragile sites in the generation of cancer-specific chromosomal rearrangements.

  18. Concordance of HER2 expression in paired primary and metastatic sites of gastric and gastro-oesophageal junction cancers.

    Science.gov (United States)

    Wong, Daniel D; Kumarasinghe, M Priyanthi; Platten, Michael A; de Boer, W Bastiaan

    2015-12-01

    HER2 is amplified/overexpressed in a subset of gastric and gastro-oesophageal junction cancers. Addition of anti-HER2 therapy has been shown to provide survival benefit in this setting. However, there are limited data assessing the concordance of HER2 status between primary and metastatic sites.A total of 113 samples from 43 paired primary and metastatic tumours were tested for HER2 status, by immunohistochemistry (IHC) for protein expression and silver in situ hybridisation (SISH) for gene amplification.Primary sites tested included endoscopic biopsies (n = 30) and resections (n = 24). Metastatic samples included lymph nodes (n = 29), peritoneal effusions (n = 21) and miscellaneous sites (n = 9). The overall HER2+ rate was 11%. Of 41 (95%; 95% CI 88.5-100%) concordant cases, 38 were HER2- and three were HER2+. There were two (5%) discordant cases, one of which showed heterogeneity of HER2 expression.This series confirms a high concordance rate of 95%, supporting that testing of primary tumours and metastases is equally valid and providing clinical rationale for the addition of anti-HER2 therapy in HER2+ disseminated disease.

  19. Internal Mammary Recipient Site Breast Cancer Recurrence Following Delayed Microvascular Breast Reconstruction

    Science.gov (United States)

    Rosich-Medina, Anais; Wang, Susan; Erel, Ertan; Malata, Charles M.

    2013-01-01

    Objective: The internal mammary vessels are a popular recipient site for microsurgical anastomoses of free flap breast reconstructions. We, however, observed 3 patients undergoing internal mammary vessel delayed free flap breast reconstruction that subsequently developed tumor recurrence at this site. We reviewed their characteristics to determine whether there was a correlation between delayed microsurgical reconstruction and local recurrence. Methods: A retrospective review of a single surgeon's delayed free flap breast reconstructions using the internal mammary vessels was conducted over a 7-year period to identify the time intervals between mastectomy and delayed breast reconstruction and between delayed breast reconstruction and recurrence. Results: Three patients developed local recurrence at the site of the microvascular anastomoses following delayed breast reconstruction. All patients had been disease-free following mastectomy. The median time interval between mastectomy and delayed breast reconstruction was 28 months (range = 20-120 months) while that between delayed breast reconstruction and local recurrence was 7 months (range = 4-10 months). Two patients died from metastatic disease, 36 and 72 months following their local recurrence. One patient remains alive 44 months after reconstruction. Conclusions: Local tumor recurrence at the internal mammary vessel dissection site following delayed breast reconstruction raises the question whether these 2 events may be related. Specifically, could internal mammary vessel dissection undertaken for delayed microsurgical reconstruction predispose to recurrence in the internal mammary lymph nodes? Further research is needed to ascertain whether delayed breast reconstruction increases the risk of local recurrence in this patient group. PMID:23383360

  20. Rapid on-site evaluation of axillary fine-needle aspiration cytology in breast cancer.

    LENUS (Irish Health Repository)

    O'Leary, D P

    2012-06-01

    Axillary ultrasonography (AUS) and fine-needle aspiration cytology (FNAC) can establish axillary lymph node status before surgery, although this technique is hampered by poor adequacy rates. To achieve consistently high rates of FNAC adequacy, rapid on-site evaluation (ROSE) of FNAC samples was introduced.

  1. 超临界水冷堆CSR1000燃料组件子通道分析%Subchannel Analysis of SCWR CSR1000 Assembly

    Institute of Scientific and Technical Information of China (English)

    杜代全; 肖泽军; 闫晓; 曾小康; 黄彦平

    2013-01-01

    利用实验数据和计算流体力学(CFD)商用软件CFX对现有子通道分析模型进行研究,分析其在超临界水冷堆(SCWR)分析中的适用性,并根据分析结果对ATHAS程序进行改进.采用改进的ATHAS程序对超临界水冷堆CSR1000燃料组件进行稳态子通道分析,获得燃料组件冷却剂和包壳温度分布、流动压降等参数.结果表明:减小螺旋肋螺距(Hw)可展平燃料组件冷却剂出口温度分布、降低包壳表面最高温度(MCST),但同时燃料组件流动阻力将增大.%Subchannel analysis models have been investigated for SCWR fuel assembly by using experimental data available and Computational Fluid Dynamics(CFD) code in the present paper, which applicability in SCWR analysis is also analyzed, and the analysis results is used to improve the ATHAS code.The steady state subchannel analysis is conducted on the CSR1000 fuel assembly using the improve ATHAS, to obtain the temperature distribution of coolant and cladding and pressure drop in assembly.The result shows that, smaller pitch will flatten the profile of coolant temperature and reduce MCST, but it also increases the pressure drop in the assembly.

  2. Autophagy and TGF-Beta Antagonist Signaling in Breast Cancer Dormancy at Premetastatic Sites

    Science.gov (United States)

    2015-06-01

    development of estrogen receptor- negative mammary tumors in mice. Journal of the National Cancer Institute 101, 107-113 (2009). 7. Borrell-Pages, M...harboring triple modality reporter gene and (1) tetracycline (tet)-inducible LacZ shRNA as control, (2) tet-inducible ATG7-shRNA (two constructs...establish 4T07 cell lines expressing triple modality reporter gene, tet-inducible Coco expression, and tet-inducible shRNA against autophagy genes or LacZ

  3. Finding the Link between CSR Reporting and Corporate Financial Performance: Evidence on Czech and Estonian Listed Companies

    Directory of Open Access Journals (Sweden)

    Jiří Strouhal

    2015-09-01

    Full Text Available Despite the fact that obligations to publish reports on corporate social responsibility will come into force in the European Union from 2018, an increasing number of companies are starting to implement corporate social responsibility (CSR policy into their everyday business practices, and as a result the information of this activity is disclosed in CSR reports or within annual reports. As the disclosure of such information is currently voluntarily based, we believe that the growing popularity of CSR leads to a direct link between the sustainability of the company and its financial performance. The purpose of this paper is therefore to determine the linkage between CSR and financial performance within two countries in the CEE region – Czech and Estonia – using data from 2012 - 2013. We compare return on assets and normalized market value added of listed companies. Based on the results, we can state that the implementation of a standalone CSR report does not have any direct linkage with the financial performance of the tested companies.

  4. A call to action on women's health: putting corporate CSR standards for workplace health on the global health agenda.

    Science.gov (United States)

    Wofford, David; MacDonald, Shawn; Rodehau, Carolyn

    2016-11-04

    Business operates within a Corporate Social Responsibility (CSR) system that the global health community should harness to advance women's health and related sustainable development goals for workers and communities in low- and middle-income countries. Corporations and their vast networks of supplier companies, particularly in manufacturing and agribusiness, employ millions of workers, increasingly comprised of young women, who lack access to health information, products and services. However, occupational safety and health practices focus primarily on safety issues and fail to address the health needs, including reproductive health, of women workers. CSR policy has focused on shaping corporate policies and practices related to the environment, labor, and human rights, but has also ignored the health needs of women workers. The authors present a new way for global health to understand CSR - as a set of regulatory processes governed by civil society, international institutions, business, and government that set, monitor, and enforce emerging standards related to the role of business in society. They call this the CSR system. They argue that the global health community needs to think differently about the role of corporations in public health, which has been as "partners," and that the global health practitioners should play the same advocacy role in the CSR system for corporate health policies as it does for government and international health policies.

  5. The post-transcriptional regulatory system CSR controls the balance of metabolic pools in upper glycolysis of Escherichia coli.

    Science.gov (United States)

    Morin, Manon; Ropers, Delphine; Letisse, Fabien; Laguerre, Sandrine; Portais, Jean-Charles; Cocaign-Bousquet, Muriel; Enjalbert, Brice

    2016-05-01

    Metabolic control in Escherichia coli is a complex process involving multilevel regulatory systems but the involvement of post-transcriptional regulation is uncertain. The post-transcriptional factor CsrA is stated as being the only regulator essential for the use of glycolytic substrates. A dozen enzymes in the central carbon metabolism (CCM) have been reported as potentially controlled by CsrA, but its impact on the CCM functioning has not been demonstrated. Here, a multiscale analysis was performed in a wild-type strain and its isogenic mutant attenuated for CsrA (including growth parameters, gene expression levels, metabolite pools, abundance of enzymes and fluxes). Data integration and regulation analysis showed a coordinated control of the expression of glycolytic enzymes. This also revealed the imbalance of metabolite pools in the csrA mutant upper glycolysis, before the phosphofructokinase PfkA step. This imbalance is associated with a glucose-phosphate stress. Restoring PfkA activity in the csrA mutant strain suppressed this stress and increased the mutant growth rate on glucose. Thus, the carbon storage regulator system is essential for the effective functioning of the upper glycolysis mainly through its control of PfkA. This work demonstrates the pivotal role of post-transcriptional regulation to shape the carbon metabolism.

  6. An illegitimate microRNA target site within the 3' UTR of MDM4 affects ovarian cancer progression and chemosensitivity

    DEFF Research Database (Denmark)

    Wynendaele, Jessika; Böhnke, Anja; Leucci, Eleonora

    2010-01-01

    Overexpression of MDM4 (also known as MDMX or HDMX) is thought to promote tumorigenesis by decreasing p53 tumor suppressor function. Even modest decrease in Mdm4 levels affects tumorigenesis in mice, suggesting that genetic variants of MDM4 might have similar effects in humans. We sequenced the MDM......4 gene in a series of ovarian cancer cell lines and carcinomas to identify mutations and/or single nucleotide polymorphisms (SNPs). We identified an SNP (SNP34091) in the 3'-UTR of MDM4 that creates a putative target site for hsa-miR-191, a microRNA that is highly expressed in normal and tumor...... tissues. Biochemical evidence supports specific miR-191-dependent regulation of the MDM4-C, but not MDM4-A, variant. Consistently, the A-allele was associated with statistically significant increased expression of MDM4 mRNA and protein levels in ovarian carcinomas. Importantly, the wild-type genotype (A...

  7. CSR的辐射屏蔽设计%Radiation Shielding Design of CSR

    Institute of Scientific and Technical Information of China (English)

    苏有武; 李武元; 李宗强; 郑华智; 朱小龙

    2005-01-01

    The construction of CSR (cooling storage ring) which includes a main ring (CSRm) and an experimental ring (CSRe) will be finished at the end of 2005. Heavy ions of carbon to uranium will be accelerated up to 900MeV/u and 400MeV/u at intensity of 108 pps. The HIRFL (heavy ion research facility in Lanzhou)will be used as the injector. For the shielding design of CSR, the secondary neutrons due to the ion beam loss,their spectra and angular distributions were estimated based on the experimental results. The dose equivalent outside the shielding surface and in the surrounding environment and the neutron skyshine dose equivalent were also estimated in this study. The experimental result, neutron yield, spectrum and angular distribution for 400MeV/u 12C+Cu reaction were used for estimating the source term of shielding design. It is found that the most important environmental radiation impact component of CSR is the skyshine neutrons.%CSR(cooling storage ring)按计划将于2005年底建成调束,届时从12C到238U的重离子将可以分别被加速到900和400MeV的能量.HIRFL(兰州重离子加速器Heavy Ion Research Facility in Lanzhou)将用作CSR的注入器.为了CSR的屏蔽设计,本文利用现有的实验数据计算了由于束流损失产生的中子及其能谱、角分布,同时也估算了屏蔽体外表面的中子剂量、环境中子剂量及天空返照中子剂量.在源项计算中使用了400MeV/u12C+Cu反应的中子产额、能谱、角分布的实验数据.计算表明,CSR对环境剂量影响最大的是天空返照中子.

  8. HIRFL-CSR Internal Target System%HIRFL-CSR实验环内靶系统

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    兰州重离子加速器冷却储存环(HIRFL-CSR)的内靶系统, 是用于为实验环内的物理实验提供厚度为1011-1013 atoms/cm2的团簇靶和极化靶. 采用超声喷气技术获得团簇粒子束, 采用Stern-Gerlach方法获得极化氢束和极化氘束.

  9. Interferometry imaging for the evolving source in heavy ion collisions at HIRFL-CSR energy

    Institute of Scientific and Technical Information of China (English)

    YIN Hong-Jie; M. J. Efaaf; ZHANG Wei-Ning

    2012-01-01

    Imaging analysis of two-pion interferometry is performed for an evolving particle-emitting source in heavy ion collisions at HIRFL-CSR energy.The source evolution is described by the relativistic hydrodynamics in (2+1) dimensions. The model-independent characteristic quantities of the source are investigated and compared with the interferometry results obtained by the usual Gaussian formula fit.It is found that the firstorder source function moments can describe the source sizes.The ratio of the normalized standard deviation (O) to the first-order moment (R),(O)/(R),is sensitive to the shape of the source function.

  10. Adaptive Row-grouped CSR Format for Storing of Sparse Matrices on GPU

    CERN Document Server

    Heller, Martin

    2012-01-01

    We present new adaptive format for storing sparse matrices on GPU. We compare it with several other formats including CUSPARSE which is today probably the best choice for processing of sparse matrices on GPU in CUDA. Contrary to CUSPARSE which works with common CSR format, our new format requires conversion. However, multiplication of sparse-matrix and vector is significantly faster for many atrices. We demonstrate it on set of 1 600 matrices and we show for what types of matrices our format is profitable.

  11. Beam dynamics design of the main accelerating section with KONUS in the CSR-LINAC

    CERN Document Server

    Xiao-Hu, Zhang; Jia-Wen, Xia; Xue-Jun, Yin; Heng, Du

    2013-01-01

    The CSR-LINAC injector has been proposed in Heavy Ion Research Facility in Lanzhou (HIRFL). The linac mainly consists of two parts, the RFQ and the IH-DTL. The KONUS (Kombinierte Null Grad Struktur) concept has been introduced into the DTL section. In this paper, the re-matching of the main accelerating section will be finished in the 3.7 MeV/u scheme and the new beam dynamics design up to 7 MeV/u will be also shown. Through the beam re-matching, the relative emittance growth has been suppressed greatly along the linac.

  12. Primary Recrystallization of Grain Oriented Silicon Steel Strip Rolled by CSR and Annealed in Magnetic Field

    Institute of Scientific and Technical Information of China (English)

    En LIU; Kemin QI; Xiuhua GAO; Chunlin QIU; Hezhou YE

    2005-01-01

    The magnetic properties and textures of grain oriented silicon steel with different thickness rolled by cross shear rolling (CSR) of different mismatched speed ratio (MSR) and annealed in magnetic field under hydrogen were presented.Effects of the factors such as thickness and mismatched speed ratio on the magnetic properties and recrystallization texture were analyzed and the recrystallization principles in magnetic field annealing were discussed. The study would provide a new route for mass production of high quality ultra-thin grain oriented silicon steel strip.

  13. Radiotherapeutic concepts in cancer of unknown primary site; Strahlentherapeutische Konzepte beim CUP-Syndrom

    Energy Technology Data Exchange (ETDEWEB)

    Krug, D.; Debus, J.; Sterzing, F. [Universitaetsklinikum Heidelberg, Klinik fuer Radioonkologie und Strahlentherapie, Heidelberg (Germany)

    2014-02-15

    The term cancer of unknown primary (CUP) encompasses a group of entities which differ to a great extent regarding etiology, prognosis and therapeutic management. The aim of the study was an elaboration of the role of radiotherapy in CUP syndrome. Systematic literature search and specification of the available treatment options. Radiotherapy is an integral part of interdisciplinary management approaches for patients with CUP in both curative and palliative situations. Radio-oncological techniques, such as intensity-modulated radiotherapy and stereotactic body radiotherapy increase the therapeutic window. Modern diagnostic modalities from radiology and nuclear medicine are the cornerstone of radiotherapeutic interventions, especially in terms of target volume definition and pretherapeutic staging. In the interdisciplinary setting radiation oncology offers the possibility of curative and often organ preserving approaches in patients with axillary and cervical CUP. In addition, improvement and preservation of quality of life can be achieved in patients with metastatic disease. Radiation oncology is a crucial component of the interdisciplinary management of patients with CUP. Therapeutic decisions in patients with CUP should be made in an interdisciplinary setting. (orig.) [German] Das Cancer-of-unknown-primary(CUP)-Syndrom fasst eine Gruppe von Erkrankungen zusammen, die durch eine ausgepraegte Heterogenitaet hinsichtlich Aetiologie, Therapie und Prognose gepraegt sind. Darstellung der Rolle der Strahlentherapie beim CUP-Syndrom. Systematische Literaturrecherche und Erlaeuterung der Behandlungsoptionen. Die Strahlentherapie ist beim CUP-Syndrom sowohl in adjuvanten und definitiven Therapiekonzepten wie auch in palliativer Intention etabliert. Technisch innovative Verfahren wie die intensitaetsmodulierte Radiotherapie und die stereotaktische Bestrahlung im Koerperstammbereich ermoeglichen eine Vergroesserung der therapeutischen Breite. Eine leistungsfaehige und moderne

  14. The Role of Organizational Leadership to Enhance Top 10 CSR Issues and Trends in The Global Economy

    Directory of Open Access Journals (Sweden)

    Dewi Rachmayanti

    2014-08-01

    Full Text Available Research on leadership and its relationship with organizational performance have been carried out and not considered Corporate Social Responsibility (CSR performance, especially in the field of community development (Comdev and even done partially. This study aims to investigate the role of organizational leadership to enhance Top 10 CSR issues and trends in the global economy which defines roles and leadership competencies. Thirteen experts were involved in the Forum of Multi Stakeholder Corporate Social Responsibility (MSHCSR through Focus Group Discussion (FGD. Data by cluster random sampling were statistically analyzed with Assumption Surfacing and Testing Strategy (SAST. The results showed from FGD experts stating if eight roles and eight competencies of the organization’s leadership is very important and influential to enhance Top 10 CSR issues and trends in the global economy.

  15. Bright luminescence of Vibrio fischeri aconitase mutants reveals a connection between citrate and the Gac/Csr regulatory system.

    Science.gov (United States)

    Septer, Alecia N; Bose, Jeffrey L; Lipzen, Anna; Martin, Joel; Whistler, Cheryl; Stabb, Eric V

    2015-01-01

    The Gac/Csr regulatory system is conserved throughout the γ-proteobacteria and controls key pathways in central carbon metabolism, quorum sensing, biofilm formation and virulence in important plant and animal pathogens. Here we show that elevated intracellular citrate levels in a Vibrio fischeri aconitase mutant correlate with activation of the Gac/Csr cascade and induction of bright luminescence. Spontaneous or directed mutations in the gene that encodes citrate synthase reversed the bright luminescence of aconitase mutants, eliminated their citrate accumulation and reversed their elevated expression of CsrB. Our data elucidate a correlative link between central metabolic and regulatory pathways, and they suggest that the Gac system senses a blockage at the aconitase step of the tricarboxylic acid cycle, either through elevated citrate levels or a secondary metabolic effect of citrate accumulation, and responds by modulating carbon flow and various functions associated with host colonization, including bioluminescence.

  16. Demographics-based differences in the relationship between perceived CSR and customer loyalty in the dairy products market

    Directory of Open Access Journals (Sweden)

    Moisescu Ovidiu-Ioan

    2015-09-01

    Full Text Available The purpose of the current paper is to investigate the demographics-based differences in the relationship between customers’ perceptions of corporate social responsibility (CSR and their loyalty towards brands/companies in the dairy products market, considering the socio-cultural and economic particularities of one of the largest countries of Central-Eastern Europe. For this purpose, a survey was implemented among a sample of 1461 dairy products consumers from the urban area of Romania, investigating perceived CSR and customer loyalty by using 28, and, respectively, 6 Likert-type items. Results show that customers’ loyalty towards dairy brands/companies is positively and significantly influenced by how customers perceive companies’ responsibility towards their customers, in all investigated demographic segments. However, there are other facets of perceived CSR (community development, the environment, economic success, sponsorship, public authorities in which case the relationship with customer loyalty is only significant in certain demographics-based market segments

  17. A Functional Variant at the miR-214 Binding Site in the Methylenetetrahydrofolatereductase Gene Alters Susceptibility to Gastric Cancer in a Chinese Han Population

    Directory of Open Access Journals (Sweden)

    Qiaoyun Chen

    2015-05-01

    Full Text Available Background and Aims: Single nucleotide polymorphisms in miRNA binding sites, which are located in mRNA 3' untranslated regions (3'-UTRs, were recently found to influence microRNA-target interactions. Specifically, such polymorphisms can modulatebinding affinity or create or destroy miRNA-binding sites; such variants have also been found to be associated with cancer risk. In this study, we explored the effect of a functional variant at the miR-214 binding site in the methylenetetrahydrofolate reductase gene (rs114673809 on gastric cancer (GC risk in a hospital-based case-control study in a Chinese Han population. Methods and Results: We genotyped the rs114673809 polymorphism in 345 gastric cancer patients and 376 cancer-free controls using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP technique. The functions of rs114673809 were investigated using a luciferase activity assay and validated by immunoblotting. We found that participants carrying the rs114673809 AA genotype or A allele had a significantly increased risk of gastric cancer (OR = 1.667, 95% CI = 1.044-2.660, P = 0.034; OR = 1.261, 95% CI = 1.017-1.563, P = 0.037, respectively compared to those carrying the GG genotype and G allele. In addition, rs114673809 modified the binding of hsa-miR-214 to MTHFR as well as MTHFR protein levels in gastric cancer patients. Conclusion: Our data suggested that rs114673809, which is located at the miR-214 binding site in the 3'-UTR of MTHFR, may play an important role in the development of gastric cancer in a Chinese Han population.

  18. The Effect of Corporate Governance Elements on Corporate Social Responsibility (CSR Disclosure: An Empirical Evidence from Listed Companies at KSE Pakistan

    Directory of Open Access Journals (Sweden)

    Sadia Majeed

    2015-11-01

    Full Text Available The purpose of this study is to investigate the potential effects of corporate governance (CG elements on corporate social responsibility (CSR disclosure. The annual reports of companies for the year 2007–2011 are examined to analyze the relationship between CG and CSR reporting. It considers the elements of CG such as board size, independent directors, foreign nationalities and women representation in the board, ownership concentration, institutional ownership, firm size and profitability. The multiple regression technique is used to measure the impact of CG elements on companies’ CSR reporting. The results of the study demonstrate that overall CSR reporting by Pakistani companies are rather moderate however, the assortments of CSR items are really impressive. The study found positive and significant impact from board size, institutions ownership, ownership concentration and firm size on CSR reporting. The results also display contrary relationships between the women and foreign director’s representation in the board and CSR reporting. This study suggests that organizations should audit their CG activities related to CSR in order to prove themselves good corporate citizens to all stakeholders.

  19. Non-Oriented Fe-Si Thin Strip Produced from Grain Oriented Fe-Si Strip by CSR

    Institute of Scientific and Technical Information of China (English)

    YE He-zhou; QI Ke-min; GAO Xiu-hua; QIU Chun-lin; LIU En

    2004-01-01

    The grain oriented silicon strip was rolled by cross shear rolling (CSR) and then annealed to manufacture non-oriented thin silicon strip of high quality. The recrystallization of rolled grain-oriented silicon steel into non-oriented silicon steel was studied. For this purpose, CSR is better than conventional rolling, and the higher the mismatched speed rate is, the better the properties of the non-oriented thin silicon strip are. The optimum annealing schedule is heating at 1 000 ℃ for 1 h in pure hydrogen atmosphere added with H2S of 0.001 0 %.

  20. The achievement of market study on a representative sample of companies in Romania about SD and CSR communication

    Directory of Open Access Journals (Sweden)

    Mihaela Bucur

    2014-05-01

    Full Text Available The purpose of this paper is to provide some results on how firms in Romania made communication on Corporate Social Responsibility (CSR and sustainable development (SD. The paper identifies the real pulse of Romanian business on the premise of communication responsible. Our approach shows how communication is performed inside and outside the company, the issues of CSR in the world customers, suppliers, business partners and customers. The findings demonstrate where are communication problems which components are satisfied through communication and where there should be improvements.

  1. Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy

    Institute of Scientific and Technical Information of China (English)

    Yanfen Liu; Yihong Ye

    2011-01-01

    To deal with the constant challenge of protein misfolding in the endoplasmic reticulum (ER), eukaryotic cells have evolved an ER protein quality control (ERQC) mechanism that is integrated with an adaptive stress response. The ERQC pathway is comprised of factors residing in the ER lumen that function in the identification and retention of aberrantly folded proteins, factors in the ER membrane for retrotranslocation of misfolded polypeptides, and enzymes in the cytosol that degrade retrotranslocated proteins. The integrated stress response (termed ER stress or unfolded protein response, UPR) contains several signaling branches elicited from the ER membrane, which fine-tune the rate of protein synthesis and entry into the ER to match the ER folding capacity. The fitness of the cell, particularly those bearing a high secretory burden, is critically dependent on functional integrity of the ER, which in turn relies on these stress-attenuating mechanisms to maintain protein homeostasis, or proteostasis. Aberrant proteostasis can trigger cellular apoptosis, making these adaptive stress response systems attractive targets for perturbation in treatment of cell malignancies. Here, we review our current understanding of how the cell preserves ER proteostasis and discuss how we may harness the mechanistic information on this process to develop new cancer therapeutics.

  2. “Identification Card”:Sites on Histone Modification of Cancer Cell

    Institute of Scientific and Technical Information of China (English)

    Chao Huang; Bin Wen

    2015-01-01

    Formation of malignant tumor originating from normal healthy cell is a multistep process including genetic and epigenetic lesions. Previous studies of cell line model systems displayed that early important epigenetic events happened in stepwise fashion prior to cell immortalization. Once these epigenetic alterations are integrated into chromatin, they will perform vertical propagation through cell subculture. Hence, status of epigenetics is dramatically important in maintaining of cell identity. Histone modification is another factor of epigenetic alterations during human oncogenesis. Histones, one of main components of chromatin, can be modified post-translationally. Histone tail modifications are regulated by corresponding modification enzymes. This review focuses on the description of relationship between the main sites of histone modification and oncogenesis.

  3. Sulindac-derived RXRα modulators inhibit cancer cell growth by binding to a novel site.

    Science.gov (United States)

    Chen, Liqun; Wang, Zhi-Gang; Aleshin, Alexander E; Chen, Fan; Chen, Jiebo; Jiang, Fuquan; Alitongbieke, Gulimiran; Zeng, Zhiping; Ma, Yue; Huang, Mingfeng; Zhou, Hu; Cadwell, Gregory; Zheng, Jian-Feng; Huang, Pei-Qiang; Liddington, Robert C; Zhang, Xiao-kun; Su, Ying

    2014-05-22

    Retinoid X receptor-alpha (RXRα), an intriguing and unique drug target, can serve as an intracellular target mediating the anticancer effects of certain nonsteroidal anti-inflammatory drugs (NSAIDs), including sulindac. We report the synthesis and characterization of two sulindac analogs, K-8008 and K-8012, which exert improved anticancer activities over sulindac in a RXRα-dependent manner. The analogs inhibit the interaction of the N-terminally truncated RXRα (tRXRα) with the p85α subunit of PI3K, leading to suppression of AKT activation and induction of apoptosis. Crystal structures of the RXRα ligand-binding domain (LBD) with K-8008 or K-8012 reveal that both compounds bind to tetrameric RXRα LBD at a site different from the classical ligand-binding pocket. Thus, these results identify K-8008 and K-8012 as tRXRα modulators and define a binding mechanism for regulating the nongenomic action of tRXRα.

  4. Applying & Publishing GRI framework in Transport Companies Rethink. Redesign. Rebuild. CSR Reporting and Climate Change

    Directory of Open Access Journals (Sweden)

    Lilian Soares Outtes Wanderley

    2010-08-01

    Full Text Available Corporations with systematic relationships to tourism are developing activities and publishing CSR reports applying the GRI framework (GRI, 2009. The contribution of tourism to climate change is estimated at between 5% and 12% and by 2050 the amount spent on the tourism sector will consume the entire carbon budget required to avoid dangerous climate change (Scott et al. 2009, UNWTO-UNEP-WMO 2008. This study defines the TC-8 group, a group of transport in tourism related companies, in order to answer the main questions:To what extent is climate change addressed in the CSR reports of transport companies? Climate change is mentioned and receives attention in all of the company reports analysed, however,overall the transport sector shows that in comparison to the GRI/KPMG (2007 survey, it under-performs. Are the companies just reporting direct emissions from production or also broader emissions from the use of the products? Half of these companies report emissions; some include direct and indirect emissions. Further actions can be mentioned such as, companies participating in forums discussing solutions to climate change, assuming shared responsibilities and employing measures such as reducing energy consumption by runningtheir own photovoltaic power unit or planning for a CO2 neutral operation by 2012.

  5. How do Companies Invest in Corporate Social Responsibility? An Ordonomic Contribution for Empirical CSR Research

    Directory of Open Access Journals (Sweden)

    Matthias Georg Will

    2014-07-01

    Full Text Available This paper takes both a conceptual and an empirical approach to answer the question as to how Corporate Social Responsibility (CSR can be connected to the company’s role as an agent of social value creation when it operates within an imperfect institutional framework of market competition. To develop a functional design for an empirical study, we draw on the concept of ordonomics, which provides a heuristics for responsible business activities in society. Drawing on ordonomics, we devise three questions: Referring to action responsibility we ask in which CSR activities companies do invest in their day-to-day business. Referring to governance responsibility we ask as to how companies realize win-win solutions through strategic commitments. In addition, with regard to discourse responsibility we ask in which stakeholder dialogues companies engage in order to discuss and find functional rules for organizing win-win solutions. In our empirical study, we reveal insights into the micro-level analysis of the CSP-CFP link and generate several new questions to be the subject of future research.

  6. Active spot-scanning test with heavy ions at HIRFL-CSR

    Institute of Scientific and Technical Information of China (English)

    DAI Zhong-Ying; LI Qiang; LIU Xin-Guo; JIN Xiao-Dong; HUANG Qi-Yan; XIAO Guo-Qing

    2012-01-01

    An active spot beam delivery system for heavy ion therapy has been developed based on the Cooling Storage Ring at HIRFL-CSR,where the pencil carbon-ion beams were scanned within a target volume transversely by a pair of orthogonal (horizontal and vertical) dipole magnets to paint the slices of the target volume and longitudinally by active energy variation of the synchrotron slice by slice.The unique techniques such as dose shaping via active energy variation and magnetic deflection constitute a promising three-dimensional conformal even intensity-modulated radiotherapy with heavy ions at HIRFL-CSR.In this paper,the verification of active energy variation and the calibration of steerable beam deflection are shown,as the basic functionality components of the active spot-scanning system.Additionally,based on the capability of creating homogeneous irradiation fields with steerable pencil beams,a radiobiological experiment like cell survival measurement has been performed aiming at comparison of the radiobiological effects under active and passive beam deliveries.

  7. MODIS Collection 6 Clear Sky Restoral (CSR): Filtering Cloud Mast 'Not Clear' Pixels

    Science.gov (United States)

    Meyer, Kerry G.; Platnick, Steven Edward; Wind, Galina; Riedi, Jerome

    2014-01-01

    Correctly identifying cloudy pixels appropriate for the MOD06 cloud optical and microphysical property retrievals is accomplished in large part using results from the MOD35 1km cloud mask tests (note there are also two 250m subpixel cloud mask tests that can convert the 1km cloudy designations to clear sky). However, because MOD35 is by design clear sky conservative (i.e., it identifies "not clear" pixels), certain situations exist in which pixels identified by MOD35 as "cloudy" are nevertheless likely to be poor retrieval candidates. For instance, near the edge of clouds or within broken cloud fields, a given 1km MODIS field of view (FOV) may in fact only be partially cloudy. This can be problematic for the MOD06 retrievals because in these cases the assumptions of a completely overcast homogenous cloudy FOV and 1-dimensional plane-parallel radiative transfer no longer hold, and subsequent retrievals will be of low confidence. Furthermore, some pixels may be identified by MOD35 as "cloudy" for reasons other than the presence of clouds, such as scenes with thick smoke or lofted dust, and should therefore not be retrieved as clouds. With such situations in mind, a Clear Sky Restoral (CSR) algorithm was introduced in C5 that attempts to identify pixels expected to be poor retrieval candidates. Table 1 provides SDS locations for CSR and partly cloudy (PCL) pixels.

  8. I Will Do It If I Enjoy It! The Moderating Effect of Seeking Sensory Pleasure When Exposed to Participatory CSR Campaigns

    Science.gov (United States)

    Ruiz de Maya, Salvador; Lardín-Zambudio, Rafaela; López-López, Inés

    2016-01-01

    In an attempt to gain differentiation, companies are allocating resources to corporate social responsibility (CSR) initiatives. At the same time, they are giving consumers a more active role in the process of creating value. In this sense, consumer participation represents a new approach to gain competitive advantage. However, the effectiveness of consumer participation in CSR campaigns still remains unknown. With the purpose of shedding light on this issue, this paper shows that participatory CSR campaigns lead to greater consumer perceptions of CSR, which in turn results in more favorable attitudes toward the company. Furthermore, the effect is stronger for sensory pleasure seekers, whose involvement with the experience is greater. The findings contribute to the CSR literature and reveal important implications for marketers. PMID:26779070

  9. The post-transcriptional regulator CsrA plays a central role in the adaptation of bacterial pathogens to different stages of infection in animal hosts.

    Science.gov (United States)

    Lucchetti-Miganeh, Céline; Burrowes, Elizabeth; Baysse, Christine; Ermel, Gwennola

    2008-01-01

    The importance of Csr post-transcriptional systems is gradually emerging; these systems control a variety of virulence-linked physiological traits in many pathogenic bacteria. This review focuses on the central role that Csr systems play in the pathogenesis of certain bacteria and in the establishment of successful infections in animal hosts. Csr systems appear to control the 'switch' between different physiological states in the infection process; for example switching pathogens from a colonization state to a persistence state. Csr systems are controlled by two-component sensor/regulator systems and by non-coding RNAs. In addition, recent findings suggest that the RNA chaperone Hfq may play an integral role in Csr-mediated bacterial adaptation to the host environment.

  10. I Will Do It If I Enjoy It! The Moderating Effect of Seeking Sensory Pleasure When Exposed to Participatory CSR Campaigns.

    Science.gov (United States)

    Ruiz de Maya, Salvador; Lardín-Zambudio, Rafaela; López-López, Inés

    2015-01-01

    In an attempt to gain differentiation, companies are allocating resources to corporate social responsibility (CSR) initiatives. At the same time, they are giving consumers a more active role in the process of creating value. In this sense, consumer participation represents a new approach to gain competitive advantage. However, the effectiveness of consumer participation in CSR campaigns still remains unknown. With the purpose of shedding light on this issue, this paper shows that participatory CSR campaigns lead to greater consumer perceptions of CSR, which in turn results in more favorable attitudes toward the company. Furthermore, the effect is stronger for sensory pleasure seekers, whose involvement with the experience is greater. The findings contribute to the CSR literature and reveal important implications for marketers.

  11. Direct finite element computation software CSR-DSA of China Classification Society%中国船级社有限元直接计算软件CSR-DSA

    Institute of Scientific and Technical Information of China (English)

    刘玉川; 金立明; 王丽荣; 章伟星

    2010-01-01

    鉴于国际船级社协会(International Association of Classification Societies,IACS)2006年推出的散货船、双壳油船共同结构规范CSR-BC/OT的复杂性,为减小用人工方法施加载荷、处理结果和扣除腐蚀等的工作量,降低出错率,中国船级社(China Classification Society,CCS)开发出有限元直接计算软件CSR-DSA.该软件以MSC Patran为平台,并使用PCL开发实现自动扣除腐蚀,施加载荷,校核屈服、屈曲、疲劳和细化网格等功能,覆盖CSR-BC/OT的大部分直接强度分析要求.CSR-DSA已得到广泛应用,很大程度上解决该规范带来的工作量大和计算易出错等问题,可以大大缩短船舶设计和审图的工作周期、提高计算准确性.

  12. Genetic variants within microRNA-binding site of RAD51B are associated with risk of cervical cancer in Chinese women.

    Science.gov (United States)

    Hang, Dong; Zhou, Wen; Jia, Meiqun; Wang, Lihua; Zhou, Jing; Yin, Yin; Ma, Hongxia; Hu, Zhibin; Li, Ni; Shen, Hongbin

    2016-09-01

    RAD51B plays a central role in homologous recombinational repair (HRR) of DNA double-strand breaks (DSBs), which is important to prevent genomic instability, a hallmark of cancer. Recent studies suggested that common genetic variants of RAD51B may contribute to cancer susceptibility. In this study, we aimed to investigate whether potentially functional variants within miRNA-binding sites of RAD51B are associated with risk of cervical cancer. A total of 1486 cervical cancer patients and 1536 cancer-free controls were enrolled, and two genetic variants, rs963917 (A > G) and rs963918 (T > C), were genotyped in all participants. Using multivariate logistic regression analyses, we found that G allele of rs963917 conferred lower risk of cervical cancer compared to A allele (adjusted OR = 0.89, 95% CI = 0.80-0.99, P = 0.039). Similarly, rs963918 allele C was associated with a decreased risk for cervical cancer compared with allele T (adjusted OR = 0.84, 95% CI = 0.74-0.94, P = 0.004). Haplotype analyses showed that haplotype GC was also correlated with lower risk (OR = 0.83, 95% CI = 0.73-0.95, P = 0.005) compared with the most common haplotype AT. In summary, our study suggested that miRNA-binding site genetic variants of RAD51B may modify the susceptibility to cervical cancer, which is important to identify individuals with differential risk for this malignancy and to improve the effectiveness of preventive intervention.

  13. TCT-CSR 功率调节对控制绕组零序过流保护的影响%Impact of TCT-CSR Power Regulation on Zero-sequence Overcurrent Protection of Control Windings

    Institute of Scientific and Technical Information of China (English)

    张芬芬; 郑涛; 刘连光

    2016-01-01

    晶闸管控制变压器式可控并联电抗器(TCT‐CSR)具有功率大范围平滑可调、响应速度快等优势,在超/特高压电网中具有良好的应用前景。以 TCT‐CSR 低压物理模型为研究对象,针对TCT‐CSR 功率快速大幅度调节对本体保护的影响开展研究。根据 TCT‐CSR 结构及原理建立了其稳态运行及功率调节过程的简化数学模型,研究了 TCT‐CSR 功率调节的暂态特性及其对 TCT‐CSR 控制绕组零序过流保护的影响,仿真计算确定了与 TCT‐CSR 功率调节范围对应的控制绕组基波零序电流峰值和暂态持续时间两项指标。在此基础上,提出通过适当增大控制绕组电阻的方法防止本体保护误动,经过大量仿真试验的对比分析,研究确定了电阻阻值的取值范围及其防误动的效果,为 TCT‐CSR 本体参数的设计改进提供了重要参考。%Possessing such advantages as continuously adjustable reactive power and high operating speed , the thyristor controlled transformer‐type controllable shunt reactor ( TCT‐CSR) is preferred to reactive power control in extra/ultra‐high voltage transmission systems . This paper focuses on the impact of power regulation of TCT‐CSR on its protection system . Based on the structure and operating principles of TCT‐CSR , a simplified mathematical model for its operation in both the steady state and transient state during power regulation is proposed . The transient characteristics during power regulation and its influence on zero‐sequence overcurrent protection of control windings are analyzed . The fundamental zero‐sequence current peak value and the transient state duration after power regulation are determined according to simulation results . Based on this , an approach to increasing the resistance of control windings is proposed . The value of the resistor and its influence on the performance of zero‐sequence overcurrent protection

  14. Corporate Social Responsibility : Legal and semi-legal frameworks supporting CSR developments 2000-2010 and cases studies

    NARCIS (Netherlands)

    Lambooy, T.E.

    2010-01-01

    Corporate social responsibility (CSR) has rapidly gained a foothold in business. In the last decade, many companies developed 'Planet, People, Profit' strategies, and put them into practice. Governments and civil society have called on private actors to contribute in resolving the difficulties of gl

  15. The CSR-Quality Trade-Off: When can Corporate Social Responsibility and Corporate Ability Compensate Each Other?

    NARCIS (Netherlands)

    G.A.J.M. Berens (Guido); C.B.M. van Riel (Cees); J. van Rekom (Johan)

    2007-01-01

    textabstractThis paper investigates under what conditions a good corporate social responsibility (CSR) can compensate for a relatively poor corporate ability (CA) (quality), and vice versa. The authors conducted an experiment among business administration students, in which information about a finan

  16. 75 FR 65323 - The Tennis Channel, Inc. v. Comcast Cable Communications, LLC; File No. CSR-8258-P

    Science.gov (United States)

    2010-10-22

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION The Tennis Channel, Inc. v. Comcast Cable Communications, LLC; File No. CSR-8258-P AGENCY: Federal Communications Commission. ACTION: Notice. SUMMARY: This document designates a program carriage complaint...

  17. The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation.

    Science.gov (United States)

    Claycomb, Julie M; Batista, Pedro J; Pang, Ka Ming; Gu, Weifeng; Vasale, Jessica J; van Wolfswinkel, Josien C; Chaves, Daniel A; Shirayama, Masaki; Mitani, Shohei; Ketting, René F; Conte, Darryl; Mello, Craig C

    2009-10-02

    RNAi-related pathways regulate diverse processes, from developmental timing to transposon silencing. Here, we show that in C. elegans the Argonaute CSR-1, the RNA-dependent RNA polymerase EGO-1, the Dicer-related helicase DRH-3, and the Tudor-domain protein EKL-1 localize to chromosomes and are required for proper chromosome segregation. In the absence of these factors chromosomes fail to align at the metaphase plate and kinetochores do not orient to opposing spindle poles. Surprisingly, the CSR-1-interacting small RNAs (22G-RNAs) are antisense to thousands of germline-expressed protein-coding genes. Nematodes assemble holocentric chromosomes in which continuous kinetochores must span the expressed domains of the genome. We show that CSR-1 interacts with chromatin at target loci but does not downregulate target mRNA or protein levels. Instead, our findings support a model in which CSR-1 complexes target protein-coding domains to promote their proper organization within the holocentric chromosomes of C. elegans.

  18. CSR-ISSUES IN THE VALUE CHAINS OF MULTI NATIONAL COMPANIES (MNCS – CHALLENGES AND BEST PRACTISE

    Directory of Open Access Journals (Sweden)

    BARTŁOMIEJ OKWIET

    2012-12-01

    Full Text Available The following article presents the historical basis of Corporate Social Responsibility and the most common definitions of it. Another part of the article presents the fuel company and the bank with the description of its main activities in the area of CSR.

  19. CSR business models and change trajectories in the retail industry; A Dynamic Benchmark Exercise (1995-2007)

    NARCIS (Netherlands)

    Tulder, van R.; Bleijenbergh, M.; Danse, M.G.; Wiersinga, R.C.; Torppe, M.

    2009-01-01

    Sustainability or Corporate Social Responsibility (CSR) is an important societal issue that also gains momentum in the food retail industry. Companies apply different strategies towards sustainability and can alter these over time. This report presents the findings of RSM research on (changes in) bu

  20. [Long-term survival after surgical resection of a cancer of unknown primary site-a case report].

    Science.gov (United States)

    Tsukao, Yukiko; Moon, Jeong Ho; Kobayashi, Kenji; Hyuga, Satoshi; Chono, Teruhiro; Watanabe, Risa; Matsumoto, Takashi; Takemoto, Hiroyoshi; Takachi, Ko; Nishioka, Kiyonori; Aoki, Taro; Uemura, Yoshio

    2013-11-01

    We report a case of long-term survival after combination chemotherapy and surgical resection of a cancer of unknown primary site[ CUPs]. A septuagenarian female was identified as having high blood levels of carcinoembryonic antigen (CEA) during follow-up monitoring of asthma. Endoscopy and imaging studies including computed tomography (CT) and positron emission tomography (PET)-CT revealed a malignant lymph node adjacent to the abdominal aorta; however, no other lesion was detected. Therefore, we performed CT-guided biopsy and diagnosed the lesion to be a lymph node metastasis of poorly differentiated adenocarcinoma. As we considered this as a systemic disease, the patient received 2 courses of combination chemotherapy with 5-fluorouracil( 5-FU)/cisplatin( CDDP) and achieved a partial response (PR). Later, the patient received S-1 therapy as second-line chemotherapy and S-1/irinotecan( CPT-11) as third-line chemotherapy in an outpatient clinic. However, the tumor continued to grow, and therefore, we decided to perform surgical resection. Histopathological examination of the resected specimen yielded a diagnosis of metastatic adenocarcinoma of the lymph node. The patient has been well without any signs of recurrence for more than 9 years since surgery. As CUPs is generally associated with poor prognosis, this case raises the possibility that combination therapy might improve convalescence.