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Sample records for cancer research english

  1. Types of Cancer Research

    Science.gov (United States)

    An infographic from the National Cancer Institute (NCI) describing the four broad categories of cancer research: basic research, clinical research, population-based research, and translational research.

  2. Research methods for English language teachers

    CERN Document Server

    McDonough, Jo

    2014-01-01

    This book offers a lively introduction to the research methods and techniques available to English language teachers who wish to investigate aspects of their own practice. It covers qualitative and quantitative methodology and includes sections on observation, introspection, diary studies, experiments, interviews, questionnaires, numerical techniques and case study research. Each method is illustrated with examples in language teaching contexts, and techniques of data collection and analysis are introduced. The authors focus particularly on research in the classroom, on tests, materials, the

  3. Research on demand-oriented Business English learning method

    Directory of Open Access Journals (Sweden)

    Zhou Yuan

    2016-01-01

    Full Text Available Business English is integrated with visual-audio-oral English, which focuses on the application for English listening and speaking skills in common business occasions, and acquire business knowledge and improve skills through English. This paper analyzes the Business English Visual-audio-oral Course, and learning situation of higher vocational students’ learning objectives, interests, vocabulary, listening and speaking, and focuses on the research of effective methods to guide the higher vocational students to learn Business English Visual-audio-oral Course, master Business English knowledge, and improve communicative competence of Business English.

  4. Action Research for English Teachers

    Institute of Scientific and Technical Information of China (English)

    韩秋实

    2014-01-01

    As a reflective approach to teacher development,Action Research (AR)is gaining significance in education and is especially credited as providing an opportunity for professionals including both teachers and teacher educators to investigate their own classroom practice and improve it,and hopefully bring favorable changes to their classrooms.It emphasizes the role of critical reflection and always involves a problem→hypothesis→resolution cycle or spiral during which teacher researchers exert efforts to explore teaching and learning.By doing action research,language teachers can not only apply theories into practice but also be more reflective,more critical and more open to change in teach-ing approaches and methods.Despite the difficulties that teachers may have in doing action research in their busy life,it is beneficial for teach-ers to be researchers in the long run.

  5. A Reviewing on English Writing Researching in China

    Institute of Scientific and Technical Information of China (English)

    吴军莉

    2015-01-01

    English writing is also a crucial means of evaluating the language proficiency of a learner of English as second language. As a result, it is essential to review English writing researching in terms of contents, number, methods, process, feedback and as⁃sessment which can guide our English writing teaching effectively.

  6. Research on the Relationship between English Majors’ Learning Motivation and Spoken English in Chinese Context

    Institute of Scientific and Technical Information of China (English)

    陆佳佳

    2014-01-01

    With the increasing importance attached to spoken English, it is of great significance to find how the motivation of English majors affects their oral English learning outcomes. Based on the research results and theoretical frameworks of the previous studies on this area, this paper carries out research in Zhujiang College of South China Agricultural University trying to find out the types of motivation and the correlation between motivation factors of English majors and their spoken English, and thus to guide spoken English learning and teaching.

  7. English as a scientific and research language debates and discourses

    CERN Document Server

    Plo Alastrué, Ramón

    2015-01-01

    This volume examines the role of English in academic and research settings in Europe and provides recommendations on the challenges posed by the dominance of English over national languages as languages of science and research dissemination; the need for language support for academics that need to disseminate their research in English; and the effect of past and present language policies.

  8. Research on demand-oriented Business English learning method

    OpenAIRE

    Zhou Yuan

    2016-01-01

    Business English is integrated with visual-audio-oral English, which focuses on the application for English listening and speaking skills in common business occasions, and acquire business knowledge and improve skills through English. This paper analyzes the Business English Visual-audio-oral Course, and learning situation of higher vocational students’ learning objectives, interests, vocabulary, listening and speaking, and focuses on the research of effective methods to guide the higher voca...

  9. Researches and Analysis on Middle School Students’ English Learning Motivation

    Institute of Scientific and Technical Information of China (English)

    陈虹; 韩小乐

    2008-01-01

    <正>This thesis discusses the relations among English learning motivations, learning strategies and study efficiency under China’s background through reviewing the Chinese and overseas English learning motivation research, analyzing its explanation, characteristics and the questionnaire results. Several suggestions on how to stimulate and foster the students’English learning motivation have been given through the analysis of existing problems in the English study of students. I expect these would be animating English teaching in school.

  10. Peralta Cancer Research Institute

    International Nuclear Information System (INIS)

    The investigators in the cell biology program at PCRI have pioneered in the development of techniques for culturing human epithelial cells. The cancer diagnosis program has been concerned with researching new techniques for early diagnosis of breast cancer in women. The cancer treatment program has been concerned with applying cell biology and biochemistry advances to improve cancer management

  11. Disadvantages of publishing biomedical research articles in English for non-native speakers of English

    OpenAIRE

    Rezaeian, Mohsen

    2015-01-01

    OBJECTIVES: English has become the most frequently used language for scientific communication in the biomedical field. Therefore, scholars from all over the world try to publish their findings in English. This trend has a number of advantages, along with several disadvantages. METHODS: In the current article, the most important disadvantages of publishing biomedical research articles in English for non-native speakers of English are reviewed. RESULTS: The most important disadvantages of publi...

  12. Primary School English Teachers'Research Engagement%Primary School English Teachers'Research Engagement

    Institute of Scientific and Technical Information of China (English)

    Xuesong Gao; Alice Wai Kwan Chow

    2012-01-01

    Research engagement is an important means for teachers to develop their professional competence. This paper reports on an enquiry into the research engagement of a group of primary school English language teachers in Guangdong province on the Chinese mainland. Drawing on questionnaire data and teachers' interview narratives, the paper examines how these Chinese primary school teachers experienced research and what their conceptions of good quality research were. While the enquiry revealed that the participants had a variety of research experiences, it also revealed that their

  13. Experimental research on English vowel errors analysis

    Directory of Open Access Journals (Sweden)

    Huang Qiuhua

    2016-01-01

    Full Text Available Our paper analyzed relevant acoustic parameters of people’s speech samples and the results that compared with English standard pronunciation with methods of experimental phonetics by phonetic analysis software and statistical analysis software. Then we summarized phonetic pronunciation errors of college students through the analysis of English pronunciation of vowels, we found that college students’ English pronunciation are easy occur tongue position and lip shape errors during pronounce vowels. Based on analysis of pronunciation errors, we put forward targeted voice training for college students’ English pronunciation, eventually increased the students learning interest, and improved the teaching of English phonetics.

  14. Investigating Generic Structure of English Research Articles: Writing Strategy Differences between English and Indonesian Writers

    Directory of Open Access Journals (Sweden)

    Ni Ketut Mirahayuni

    2002-01-01

    Full Text Available Abstract. Research into English research articles (RAs has largely been focused on articles produced by native English writers. This paper reports a study aiming to investigate the textual structure of research articles written by non-native English (i.e. Indonesian writers, which may contribute to their acceptance for international publication. A comparison is made between RAs written by native English speakers, an Indonesian writers writing in English, all in the field of Language and Language Teaching. It explores the relation of text's generic structure. The thesis develops a framework for the generic structure analysis based on Swales' (1990 Create-A­Research-Space (CARS model of moves. The analysis focuses on two RA sections: Introduction and Discussion. The findings indicate significant differences in both forms and functions of organizing strategics between the native and non-native texts. The differences may partly be due to the influence of writing practices in the non-native writers' first language and partly to the writer's attempt to find an appropriate format in the absence of well-established research writing conventions in the first language. Consequently, non-native English texts may show organizing strategies unfamiliar to both the native English and native Indonesian texts. Findings from the research highlight two issues. First, formal and functional differences of generic structure elements and their realizations between the native and non-native English texts may disadvantage the non-native writers, particularly with regards to employment of unfamiliar organizational

  15. nvestigating Generic Structure of English Research Articles: Writing Strategy Differences between English and Indonesian Writers

    Directory of Open Access Journals (Sweden)

    Ni Ketut Mirahayuni

    2003-01-01

    Full Text Available Research into English research articles (RAs has largely been focused on articles produced by native English writers. This paper reports a study aiming to investigate the textual structure of research articles written by non-native English (i.e. Indonesian writers, which may contribute to their acceptance for international publication. A comparison is made between RAs written by native English speakers, an Indonesian writers writing in English, all in the field of Language and Language Teaching. It explores the relation of text's generic structure. The thesis develops a framework for the generic structure analysis based on Swales' (1990 Create-A-Research-Space (CARS model of moves. The analysis focuses on two RA sections: Introduction and Discussion. The findings indicate significant differences in both forms and functions of organizing strategies between the native and non-native texts. The differences may partly be due to the influence of writing practices in the non-native writers' first language and partly to the writer's attempt to find an appropriate format in the absence of well-established research writing conventions in the first language. Consequently, non-native English texts may show organizing strategies unfamiliar to both the native English and native Indonesian texts. Findings from the research highlight two issues. First, formal and functional differences of generic structure elements and their realizations between the native and non-native English texts may disadvantage the non-native writers, particularly with regards to employment of unfamiliar organizational strategies. Second, non-native English writers need to acquire knowledge of commonly used formal generic structure, and more importantly, the knowledge of the nature of scientific writing in English to be able to gain wider readership. The implications for further research and the teaching of academic writing are discussed.

  16. Profiles in Cancer Research

    Science.gov (United States)

    These articles put a face to some of the thousands of individuals who contribute to NCI’s cancer research efforts. The profiles highlight the work of scientists and clinicians and describe the circumstances and motivation behind their work.

  17. English as a Lingua Franca: Analyzing Research Frameworks in International English, World Englishes, and ELF

    Science.gov (United States)

    Pakir, Anne

    2009-01-01

    This paper considers the problems, the properties, and the prospects of using "English as a lingua franca" as a construct and as a reality. It will therefore focus on what is meant by the term "lingua franca", what is represented as a "lingua franca", and what the debates are about English as a lingua franca. The point of departure is Kachru's…

  18. Post-sampling mortality and non-response patterns in the English Cancer Patient Experience Survey: Implications for epidemiological studies based on surveys of cancer patients

    OpenAIRE

    Abel, Gary A; Saunders, Catherine L; Lyratzopoulos, Georgios

    2015-01-01

    BACKGROUND: Surveys of the experience of cancer patients are increasingly being introduced in different countries and used in cancer epidemiology research. We examine how sampling processes, post-sampling mortality and survey non-response influence the representativeness of cancer patient surveys. METHODS: We examined predictors of post-sampling mortality and non-response among patients initially included in the sampling frame of the English Cancer Patient Experience Survey. We also comp...

  19. American Institute for Cancer Research

    Science.gov (United States)

    ... Order Publications Shop AICR Health @ Work Healthy Recipes Cancer Research Update AICR eNews AICR Newsletter ScienceNow CancerResource Where ... Patients and Survivors Materials for Health Professionals Our Cancer Research Research Grants Conference Continuous Update Project Research Progress ...

  20. Research Article Introductions in English for Specific Purposes: A Comparison between Brazilian Portuguese and English

    Science.gov (United States)

    Hirano, Eliana

    2009-01-01

    This paper compares the rhetorical organization of research article introductions in Brazilian Portuguese and in English within a subfield of Applied Linguistics. Using Swales' (1990) CARS model as an analytical tool, this exploratory study investigated 20 research articles. The findings indicate that introductions in Brazilian Portuguese tend to…

  1. Planning Research on Chinese Culture English Virtual Community

    OpenAIRE

    Yina SHEN; Du, Hui; Shen, Juan

    2012-01-01

    To solve the problem existing in Chinese culture English websites, which is focusing on “introduction” while ignoring “communication”, based on the concept and core applications of virtual community, a planning research on Chinese culture English virtual community is described in this paper, which includes general requirement analysis, general structure planning and application platform planning. The aim is to provide a more comprehensive internet platform for foreigners to learn Chi...

  2. Workshop on Cancer Research

    International Nuclear Information System (INIS)

    On April, 22-24 April 1991, the Hungarian National Institute of Oncology and the Commission of the European Communities have organized a workshop on Cancer Research. The aim of the meeting was to provide the participants information on the ongoing research in Hungary and in Member States. The topic is of importance for Hungary and it was also considered that the meeting could contribute to identify subjects of possible collaboration between Hungarian and Member State laboratories in the case financial support would become available. Three papers about new therapies under development were presented proton therapy and Boron neutron capture therapy

  3. Contrastive Rhetorical Study on Korean and English Research Paper Introductions.

    Science.gov (United States)

    Lee, Sun

    2000-01-01

    Investigates differences in the rhetorical organization of research article introductions between Korean academic writing and English academic writing based on Swales' Create a Research Space model (1990). Twelve published articles written by Korean national scholars and American scholars are compared, and eight term papers by Korean…

  4. Prostate Cancer Research Trial Helps John Spencer Treat His Cancer

    Science.gov (United States)

    ... this page please turn Javascript on. Feature: Prostate Cancer Prostate Cancer Research Trial Helps John Spencer Treat His ... Read More "Prostate Cancer" Articles Progress Against Prostate Cancer / Prostate Cancer Research Trial Helps John Spencer Treat His ...

  5. Hedging and Boosting in English and Indonesian Research Articles

    Science.gov (United States)

    Sanjaya, I Nyoman Suka

    2013-01-01

    The present cross-cultural and cross-disciplinary study was aimed at exploring the similarities and differences between English and Indonesian research articles from the disciplines of applied linguistics and chemistry in terms of frequency of usage of hedges (e.g. "perhaps," "may") and boosters (e.g. "clearly,"…

  6. Research on English Teaching and Learning: Taiwan (2004-2009)

    Science.gov (United States)

    Chen, Suchiao; Tsai, Yachin

    2012-01-01

    This article analyzes research in second/foreign language teaching and learning conducted in Taiwan over the period 2004-2009. Representative articles published in local refereed journals and conference proceedings--not readily accessible outside Taiwan--are reviewed to reflect current trends in English teaching and learning. The main themes…

  7. Scandinavian Mass Communication Research: Publications in English, French and German.

    Science.gov (United States)

    Nordic Documentation Center for Mass Communication Research, Aarhus (Denmark).

    This update to the bibliographies from Nordicom edited in 1975 and 1976 lists publications on mass communications research from Denmark, Finland, and Norway, that have appeared in one or more of the three languages--English, French, or German. Materials are listed for each country separately, arranged by author (or title if there is no author),…

  8. Seeking Acceptance in an English-Only Research World

    Science.gov (United States)

    Belcher, Diane D.

    2007-01-01

    Many have noted the increasing concentration of gatekeeping power in the hands of mainstream English-only journals and made compelling cases for the need to bring more off-networked, multilingual voices into the global research conversation. Despite the hurdles that often face under-resourced off-network scholars, a number of them do find their…

  9. Biomedical research coverage in English-language Indian newspapers

    Directory of Open Access Journals (Sweden)

    Bharvi Dutt

    2012-01-01

    Full Text Available The present paper explores biomedical research coverage in the Indian English-language newspapers. Science and technology coverage in the Indian English-language newspapers revealed dominant representation of biomedical research. The research reported was mainly from foreign sources, mostly performed in US, UK and other developed countries of Europe. Plausibly, this was the major reason that areas of medical concerns in foreign countries such as Neuroscience, Oncology, Genetics and Cardiovascular research constituted more than one-third of the total space whereas neglected tropical diseases have almost been neglected in the coverage. This is despite the fact that tropical and other neglected diseases constitute the greatest health problem in India. The study discusses the significance of this research for policy planners, media, health information dissemination and those concerned about informed and science literate citizenry in the country.

  10. Naming methods and intention research in English novels

    Institute of Scientific and Technical Information of China (English)

    Li Ziyao

    2015-01-01

    Names are unique phenomenon in human society. People from different countries all have their only names, which generally consist of the first name and the last name. Not only in reality, but also in literary works, they all have their unique names, but the naming methods and intention are different. This paper emphasizes the naming methods and intention in English novels. The names of English novels usually have a richer culture, it embodies the character traits and characters in the novel, such as the outcome of their fate. Therefore, the research of the cultural intention of English novels and translating names accurately is of great significance for literary translation, which also plays an important role in the East-West cultural exchange.

  11. Questionnaire: National Research Data Survey 2015 (English)

    OpenAIRE

    Bauer, Bruno; Schmidt, Nora; Sánchez Solís, Barbara; Preza, José Luis; Mühlegger, Johannes Michael; Gumpenberger, Christian; Gründhammer, Veronika; Gorraiz, Juan; Ferus, Andreas

    2015-01-01

    In 2015, this survey was directed at the scientific and artistic-scientific personnel of all 21 public universities and three extramural research institutions in Austria. The questionnaire is based on institutional, discipline-specific surveys that have already been performed at universities and research institutions in other countries. Emphasis was placed on the creation of a specially developed questionnaire which took into consideration the different cultures in science and art.

  12. Researching Contradictions: Cultural Historical Activity Theory Research (CHAT) in the English Classroom

    Science.gov (United States)

    Thompson, Ian

    2015-01-01

    This article argues that Cultural Historical Activity Theory (CHAT) is an appropriate theoretical and methodological framework for researchers in English interested in the social contexts of culture and its relationship with the formation of mind and activity in the English classroom. Two key concepts in Vygotsky's thought central to understanding…

  13. Research in Danish cancer rehabilitation

    DEFF Research Database (Denmark)

    Høybye, Mette Terp; Dalton, Susanne Oksbjerg; Christensen, Jane;

    2008-01-01

    cancer survivors with respect to cancer site, sociodemographic variables, social network, lifestyle, self-rated health and the prevalence of cancer-related late effects. The study is part of the FOCARE research project, in which the long-term effects of the rehabilitation programme are evaluated...... rate at baseline was 86% (n = 1876). Most participants were younger women with breast cancer. They were generally well educated and working. The cancer survivors reported having comprehensive social networks and being physically active. Several cancer-related symptoms were reported by women with...... site, sex, age, family, working status and social position. These challenges might be addressed optimally in multi-dimensional rehabilitation programmes....

  14. Research Article Introductions in Chinese and English: A Comparative Genre-Based Study

    Science.gov (United States)

    Loi, Chek Kim

    2010-01-01

    This study investigates the rhetorical organisation of English and Chinese research article introductions in the field of educational psychology using (Swales, 1990) and (Swales, 2004) framework of move analysis. A corpus of 40 research articles (20 Chinese and 20 English) was selected. The English research articles, written by first-language…

  15. English

    CERN Document Server

    Nelson, Gerald

    2010-01-01

    "English: An Essential Grammar" is a concise and user-friendly guide to the grammar of modern English, written specifically for native speakers and based on genuine samples of contemporary spoken and written English. In four chapters, the book covers the essentials of English grammar, beginning with the basics and going on to deal with phrase, clause and sentence structure. A fifth chapter deals with English word formation and spelling, including problem spellings and British and American spelling variants. Features of this title include: discussion of points that often cause problem

  16. Development and reform research of English teaching theory and practice

    Institute of Scientific and Technical Information of China (English)

    Jie Guo

    2015-01-01

    The course is the core of education, which is the basic way to achieve educational goals, an educational content and value orientation are mainly expressed and implemented through the curriculum. English courses are the core of English education, which is a concrete manifestation of the value of English education, and it is basic carrier to achieve the goal of English education. This paper analyzes the development of English teaching practice, development and reform of English teaching methods.

  17. Cancer immunoinformatics: a new assistant tool for malignant disease research

    Institute of Scientific and Technical Information of China (English)

    Wang Weijia; Zhang Rupeng; Liang Han; Zhang Hui; Li Fangxuan; Yu Jinpu; Li Hui

    2014-01-01

    Objective To introduce the recent developments in cancer immunoinformatics with an emphasis on the latest trends and future direction.Data sources All related articles in this review were searched from PubMed published in English from 1992 to 2013.The search terms were cancer,immunoinformatics,immunological databases,and computational vaccinology.Study selection Original articles and reviews those were related to application of cancer immunoinformatics about tumor basic and clinical research were selected.Results Cancer immunoinformatics has been widely researched and applied in a series of fields of cancer research,including computational tools for cancer,cancer immunological databases,computational vaccinology,and cancer diagnostic workflows.Furthermore,the improvement of its theory and technology brings an enlightening insight into understanding and researching cancer and helps expound more deep and complete mechanisms of tumorigenesis and progression.Conclusion Cancer immunoinformatics provides promising methods and novel strategies for the discovery and development of tumor basic and clinical research.

  18. Scientific English: a program for addressing linguistic barriers of international research trainees in the United States.

    Science.gov (United States)

    Cameron, Carrie; Chang, Shine; Pagel, Walter

    2011-03-01

    Within the international research environment, English is indisputably the lingua franca, and thus, the majority of the world's scientists must adapt to a second language. Linguistic barriers in science affect not only researchers' career paths but institutional productivity and efficiency as well. To address these barriers, we designed and piloted a specialized course, Scientific English. The pedagogical approach is based on English for specific purposes methodology in which curriculum and content are driven by the types of daily language used and interactions which occur in the participants' occupation, in this case, cancer research. The 11-week program was organized into three sections: presentation skill, meeting and discussion skills, and writing skills. Effectiveness of the course was measured by the number of participants able to produce the presentations and written products with a score of at least 75 of 100 possible points. From January to December 2008, participant scores averaged 90.4 for presentation and 86.8 for written products. The authors provide insights and recommendations on the development and delivery of the program. PMID:20623348

  19. Mouse models for cancer research

    Institute of Scientific and Technical Information of China (English)

    Wei Zhang; Lynette Moore; Ping Ji

    2011-01-01

    Mouse models of cancer enable researchers to leamn about tumor biology in complicated and dynamic physiological systems. Since the development of gene targeting in mice, cancer biologists have been among the most frequent users of transgenic mouse models, which have dramatically increased knowledge about how cancers form and grow. The Chinese Joumnal of Cancer will publish a series of papers reporting the use of mouse models in studying genetic events in cancer cases. This editorial is an overview of the development and applications of mouse models of cancer and directs the reader to upcoming papers describing the use of these models to be published in coming issues, beginning with three articles in the current issue.

  20. Researchers Identify Early Sign of Pancreatic Cancer

    Science.gov (United States)

    ... of pancreatic cancer Researchers identify early sign of pancreatic cancer September 28, 2014 Tags: PancreaticCancer Brian Wolpin, MD ... discovered a sign of the early development of pancreatic cancer – an upsurge in certain amino acids that occurs ...

  1. Proteomics in Pancreatic Cancer Research

    Science.gov (United States)

    Geng, Ruihui; Li, Zhaoshen; Li, Shude; Gao, Jun

    2011-01-01

    Pancreatic cancer is a highly aggressive malignancy with a poor prognosis and deeply affects the life of people. Therefore, the earlier diagnosis and better treatments are urgently needed. In recent years, the proteomic technologies are well established and growing rapidly and have been widely applied in clinical applications, especially in pancreatic cancer research. In this paper, we attempt to discuss the development of current proteomic technologies and the application of proteomics to the field of pancreatic cancer research. This will explore the potential perspective in revealing pathogenesis, making the diagnosis earlier and treatment. PMID:22084685

  2. English version: Research education for diversity in educational research

    Directory of Open Access Journals (Sweden)

    Andrew Brown

    2008-06-01

    Full Text Available Concern expressed by government and other funding agencies and consumers of research, about the quality and relevance of research in the field of education affects not only the kind of research is conducted but also the way in which we educate researchers. The economic imperative for ‘value for money’ from research and researchers has, for instance, led to the education of research students to be seen increasingly in terms of training in a range of generic skills that can be applied to the investigation of a range of forms of research problem in a variety of contexts. Whilst breadth in the education of researchers has clear advantages, both for the careers of individual researchers and the wider research community, there is some tension between this approach and the more established view of a research degree as an induction into a narrow domain of knowledge and the production of a highly specialised academic identity. There are further developments that erode this notion of specialisation, for instance the growth of mixed method research, which has the potential to challenge the polarisation of qualitative and quantitative research, and shifts in the sites and agents of educational research signified by the growth of professional doctorates, which could further challenge the university as a dominant institution in the production of educational knowledge. In this paper I will explore what these developments mean for the teaching of research and consider how we can work collaboratively to develop both professional researchers and researching professionals, and reconcile the acquisition of skills with induction into specialised knowledge domains. This will involve exploration of both an overarching framework for thinking about the processes of doing research and specific examples of practice. Underlying the approach taken is a general commitment to research education, rather than to training and the teaching of methods, and the desire to ensure

  3. Research on integrated education mode in college English teaching

    OpenAIRE

    Shi Ying

    2016-01-01

    College English teaching compares with the traditional English teaching from visual-audio-oral aspects. The integrated English teaching is mainly manifested in the target, systematicness, normalization, efficiency and effectiveness of the integrated English teaching quality. With the criteria of practicability, quality, integration and language features of the integrated teaching, this paper carries out quantifiable weight analysis of the integrated college English teaching content based on A...

  4. The Research of College Students’English Classroom Behavior Investigations

    Institute of Scientific and Technical Information of China (English)

    张单

    2014-01-01

    By employing quantitative research methods, the paper investigates college students ’preferences to English classroom behaviors and the relations between behaviors and achievements. The results indicate that there are significant differences among the subjects’behavior, cognitive and emotional elements, and their classroom behaviors are mainly visual, individual, imitative and exterior-motivated;there are significant differences in behavior element and emotional element between high-result group and low-result group;confident and oral classroom behaviors have prominent relations with CET-4 achievements, and different teaching methods may make learning behaviors produce good or bad effects to achievements.

  5. Research on American English Translation of Chinese Signs in Baoding from the Perspective of Cultural Differences

    OpenAIRE

    Nan Zhao; Ruixian Ma; Xiaomei Du

    2015-01-01

    This thesis aims at analyzing the American English translation of Chinese signs in Baoding from the perspective of cultural differences. The thesis researches on signs translation from a new angle by separating American English translation from British English translation and puts special emphasis on American English signs translation, which may be helpful to the standardization of signs translation in China. Through digging out the cultural differences from different thinking mode, value, an...

  6. English

    DEFF Research Database (Denmark)

    Phillipson, Robert

    2011-01-01

    The article exemplifies and presents the characteristics of linguistic imperialism, linguistic capital accumulation following the same pattern as capitalist economic dominance. The text summarizes the way English was established in the colonial period. Many of the mechanisms of linguistic hierarchy...... have been maintained and intensified since then, as African and Indian scholarship demonstrates. Language plays a key role in education, the World Bank taking over where colonial regimes left off. Anglo-American efforts to maintain global English dominance have intensified since 1945 and are central to...... the present-day world ‘order’, as the postcolonial is subsumed under global empire, assisted by English linguistic neoimperialism. Some scholars who deny the existence of linguistic imperialism are reported on, and the complexity of language policy in European integration is demonstrated. The article...

  7. Uterine Cancer Statistics

    Science.gov (United States)

    ... Research AMIGAS Fighting Cervical Cancer Worldwide Stay Informed Statistics for Other Kinds of Cancer Breast Cervical Colorectal ( ... Skin Vaginal and Vulvar Cancer Home Uterine Cancer Statistics Language: English Español (Spanish) Recommend on Facebook Tweet ...

  8. What's New in Testicular Cancer Research and Treatment?

    Science.gov (United States)

    ... resources for testicular cancer What’s new in testicular cancer research and treatment? Important research into testicular cancer is ... Your Doctor After Treatment What`s New in Testicular Cancer Research? Other Resources and References Cancer Information Cancer Basics ...

  9. What's New in Anal Cancer Research and Treatment?

    Science.gov (United States)

    ... resources for anal cancer What’s new in anal cancer research and treatment? Important research into anal cancer is ... Your Doctor After Treatment What`s New in Anal Cancer Research? Other Resources and References Cancer Information Cancer Basics ...

  10. Breast Cancer Research at NASA

    Science.gov (United States)

    1998-01-01

    Isolation of human mammary epithelial cells (HMEC) from breast cancer susceptible tissue. Outgrowth of cells from duct element in upper right corner cultured in a standard dish; most cells spontaneously die during early cell divisions, but a few will establish long-term growth. NASA's Marshall Space Flight Center (MSFC) is sponsoring research with Bioreactors, rotating wall vessels designed to grow tissue samples in space, to understand how breast cancer works. This ground-based work studies the growth and assembly of human mammary epithelial cell (HMEC) from breast cancer susceptible tissue. Radiation can make the cells cancerous, thus allowing better comparisons of healthy vs. tunorous tissue. Credit: Dr. Robert Tichmond, NASA/Marshall Space Flight Center (MSFC).

  11. Research on interaction and communication in English teaching

    Directory of Open Access Journals (Sweden)

    Li Jing

    2016-01-01

    Full Text Available In recent years, with the continuous improvement of English teaching way, the interaction and communication way in English teaching has become an important means to improve English teaching. This paper illustrates the benefits of interaction and communication in English teaching, and introduces three interaction and communication ways in English teaching - unilateral communication between teachers and students, multi-directional communication between teachers and students, and multi-level communication between teachers and students, and carries out experimental teaching based on these three ways. This paper uses the factor analysis to analyze the student performance in listening, speaking, reading and writing, and determines the proportion of performance in these four aspects according to the analysis results. This paper evaluates the effect of role of three interaction and communication ways in English teaching according to the fuzzy comprehensive evaluation. The results show that the unilateral communication between teachers and students is slightly superior.

  12. Technology research pathways in teaching English to speakers of other languages: a new didactics research concep

    OpenAIRE

    César Eduardo Jiménez Calderón

    2013-01-01

    The objective of the study is to elaborate a systemically logicpathway of technology research methodology for teachingEnglish to speakers of other languages based on the inferentialcognitive paradigm. The inferential process consists of passingfrom previous statements, considered as true outcomes, to otherones whose propositions arise from either the need of currentreal information or the consequence of former statements. If theproposal technology research pathway is followed by educativerese...

  13. English Language Teaching Research in South Korea: A Review of Recent Studies (2009-2014)

    Science.gov (United States)

    Moodie, Ian; Nam, Hyun-Jeong

    2016-01-01

    This article reviews recent studies on English language teaching (ELT) in South Korea, where a great deal of research has been produced in recent years in local journals. In this article we review 95 studies from a pool of some 1,200 published between 2009 and 2014 on English language teaching and learning, focusing on research within the public…

  14. Some Thoughts on English for Research Publication Purposes (ERPP) and Related Issues

    Science.gov (United States)

    Flowerdew, John

    2015-01-01

    Academic writing for research publication takes place around the globe, involving, according to a recent account, 5.5 million scholars, 2,000 publishers and 17,500 research/higher education institutions (Lillis & Curry 2010: 1). Because so many scholars whose first language is not English are now using English for publication purposes and…

  15. What's New in Bile Duct Cancer Research and Treatment?

    Science.gov (United States)

    ... bile duct cancer What’s new in bile duct cancer research and treatment? Bile duct cancer is an uncommon ... Doctor After Treatment What`s New in Bile Duct Cancer Research? Other Resources and References Cancer Information Cancer Basics ...

  16. What's New in Endometrial Cancer Research and Treatment?

    Science.gov (United States)

    ... resources for endometrial cancer What`s new in endometrial cancer research and treatment? Molecular pathology of endometrial cancer For ... Your Doctor After Treatment What`s New in Endometrial Cancer Research? Other Resources and References Cancer Information Cancer Basics ...

  17. Honoring Pioneers in Breast Cancer Research

    Science.gov (United States)

    ... Current Issue Past Issues Honoring Pioneers in Breast Cancer Research Past Issues / Spring 2007 Table of Contents For ... Distinguished Medical Service Award for their pioneering breast cancer research. Photo courtesy of Bill Branson, NIH In this ...

  18. Frederick National Laboratory for Cancer Research

    Data.gov (United States)

    Federal Laboratory Consortium — Among the many cancer research laboratories operated by NCI, the Frederick National Laboratory for Cancer Research(FNLCR) is unique in that it is a Federally Funded...

  19. Gene-Environment Research and Cancer Epidemiology

    Science.gov (United States)

    The Epidemiology and Genomics Research Program supports extramural research that investigates both genetic and environmental factors that may contribute to the etiology of cancer and/or impact cancer outcomes.

  20. Center for Herbal Research on Colorectal Cancer

    Data.gov (United States)

    Federal Laboratory Consortium — Research Area: Herbs Program:Centers of Excellence for Research on CAM Description:Colorectal cancer is the third most common cancer and the third leading cause of...

  1. Phosphoproteomics and Lung Cancer Research

    Directory of Open Access Journals (Sweden)

    William C. S. Cho

    2012-09-01

    Full Text Available Massive evidence suggests that genetic abnormalities contribute to the development of lung cancer. These molecular abnormalities may serve as diagnostic, prognostic and predictive biomarkers for this deadly disease. It is imperative to search these biomarkers in different tumorigenesis pathways so as to provide the most appropriate therapy for each individual patient with lung malignancy. Phosphoproteomics is a promising technology for the identification of biomarkers and novel therapeutic targets for cancer. Thousands of proteins interact via physical and chemical association. Moreover, some proteins can covalently modify other proteins post-translationally. These post-translational modifications ultimately give rise to the emergent functions of cells in sequence, space and time. Phosphoproteomics clinical researches imply the comprehensive analysis of the proteins that are expressed in cells or tissues and can be employed at different stages. In addition, understanding the functions of phosphorylated proteins requires the study of proteomes as linked systems rather than collections of individual protein molecules. In fact, proteomics approaches coupled with affinity chromatography strategies followed by mass spectrometry have been used to elucidate relevant biological questions. This article will discuss the relevant clues of post-translational modifications, phosphorylated proteins, and useful proteomics approaches to identify molecular cancer signatures. The recent progress in phosphoproteomics research in lung cancer will be also discussed.

  2. What's New in Nasopharyngeal Cancer Research and Treatment?

    Science.gov (United States)

    ... resources for nasopharyngeal cancer What`s new in nasopharyngeal cancer research and treatment? Research into the causes, prevention, and ... Your Doctor After Treatment What`s New in Nasopharyngeal Cancer Research? Other Resources and References Cancer Information Cancer Basics ...

  3. What's New in Gallbladder Cancer Research and Treatment?

    Science.gov (United States)

    ... resources for gallbladder cancer What’s new in gallbladder cancer research and treatment? Research into the causes, diagnosis, and ... Your Doctor After Treatment What`s New in Gallbladder Cancer Research? Other Resources and References Cancer Information Cancer Basics ...

  4. What's New in Vulvar Cancer Research and Treatment?

    Science.gov (United States)

    ... resources for vulvar cancer What`s new in vulvar cancer research and treatment? Research is being done to find ... Your Doctor After Treatment What`s New in Vulvar Cancer Research? Other Resources and References Cancer Information Cancer Basics ...

  5. Translational Research in Pancreatic Cancer

    Directory of Open Access Journals (Sweden)

    Alexios S Strimpakos

    2011-03-01

    Full Text Available The high mortality rate of pancreatic cancer places this uncommon malignancy quite high as a cause of cancer related deaths. Compared to other solid tumors, there is a lag in the development of new effective drugs and the actual clinical benefit remains poor over the last decade or so. The lack of therapeutic options necessitates the invention of the important molecules playing role in pancreatic carcinogenesis and the development of specific targeted therapies. Treatment advances have to be proven first in the bench before applying them at the bedside, thus why translational research is so needed. At the 2011 American Society of Clinical Oncology (ASCO Gastrointestinal Cancers Symposium, preclinical evidence was presented regarding the efficacy of C4 compound against focal adhesion kinase (FAK (Abstract #214, the role of the cyclooxygenase-2 (COX-2 inhibitor apricoxib in enhancing the efficacy of gemcitabine and erlotinib (Abstract #227 and the role of curcumin and ABT-888 (a poly-ADP ribose polymerase (PARP inhibitor as potent radiosensitizers (Abstracts #222 and #203. Interestingly, the invention of a novel monoclonal antibody (ensituximab against the mucin epitope NPC-1C in pancreatic and colon cancer cell lines exhibited notable antibody-dependent cellular cytotoxicity (Abstract #235. Finally, enhanced selective targeting of pancreatic tumors was achieved by combining antibody-drug conjugates (ADC with radioimmunotherapy (Abstract #206.

  6. Researching the Teaching of Subject English: Socio-Cultural Theories and Methods

    Science.gov (United States)

    Exley, Beryl

    2015-01-01

    I come to this article as an experienced primary and middle years teacher and midcareer university-based academic with a vested interest in researching the message systems of the disciplinary field of subject English. My sociocultural perspective challenges those who view English teaching predominantly as a cognitive act of learning to read or…

  7. Text-Organising Metatext in Research Articles: An English-Slovene Contrastive Analysis

    Science.gov (United States)

    Peterlin, A.P.

    2005-01-01

    The paper presents a contrastive analysis focusing on the differences in the use of two selected metatext categories, previews and reviews, in English and Slovene research articles. The analysis is based on the hypothesis that the use of the selected metatext categories is more restricted in Slovene academic writing than in English academic…

  8. Teacher Professional Development through Collaborative Action Research: Impact on Foreign English-Language Teaching and Learning

    Science.gov (United States)

    Banegas, Dario; Pavese, Anahi; Velazquez, Aurelia; Velez, Sandra Maria

    2013-01-01

    In 2011 we, a group of English-as-a-foreign-language teachers at a secondary school in Argentina, decided to investigate our teaching practices through collaborative action research so as to improve our students' learning opportunities and thus revitalise English-language teaching in our context. We implemented and evaluated the integration of…

  9. Personal and Impersonal Authorial References: A Contrastive Study of English and Italian Linguistics Research Articles

    Science.gov (United States)

    Molino, Alessandra

    2010-01-01

    A cross-cultural approach is taken to analyse Linguistics research articles in English and Italian in terms of 1) the use of exclusive first-person subject pronouns in English and first-person inflected verbs in Italian, and 2) the passive voice in both languages and "si" constructions in Italian. The aim is to determine whether personal and…

  10. Learner Contribution to English Language Learning: Chinese Research Students' Agency and Their Transitional Experiences in Australia

    Science.gov (United States)

    Xu, Jianwei

    2012-01-01

    This article examines the role of agency for the English language development of three Chinese research students with high English proficiency sojourning in Australia. The focus is on the various approaches the learners employed to strengthen their sense of confidence in their language use in Australia. The data were obtained through in-depth…

  11. Autonomous Learning to Improve College English Students’English Re-search

    Institute of Scientific and Technical Information of China (English)

    WANG Yan-rong

    2015-01-01

    This paper aims to resesrch on the autonmons tearning so as to improve the college students’English learning . First of all, it introdues some basic concepts of the autonomous learning theory , Secondly, it analyzes the current situation of college Eng⁃lish students’listening and speaking. In this passage the anthor hopes that it is helpful to improve college students’listening and speaking level by their autonomous learning. It is helpful to improve their listening and speaking ability. As a result, it is helpful to develop college students’English comprehensive application ability.

  12. Research on Teaching Model in Business English Writing

    Institute of Scientific and Technical Information of China (English)

    WEN Chuan-shu

    2014-01-01

    According to the characteristics of Business English Writing Course,this essay analyses the teaching status, then in the frame of communication theory, it puts forward a new teaching model-PIADA. It is proved that this new teaching model can explore the teacher’s subjective initiative, mobilize the enthusiasm of the students fully, make the teaching process more systemat-ic and scientific, and eventually greatly improve students' English writing ability.

  13. Research on Computer English Teaching based on WEB Network

    Institute of Scientific and Technical Information of China (English)

    Liwen WANG

    2015-01-01

    With the continuous progress of the integration of information technology and English teaching course under the network environment, the traditional teaching mode cannot meet to listening teaching resources requirement, Web listening corpus is the main way to solve the problem. The paper design the small Web corpus for university English listening teaching development based on the introduction of Web corpus, and this corpus has realized to the listening material retrieval, browsing, online listening watch and update functions.

  14. Prostate cancer research in China

    Institute of Scientific and Technical Information of China (English)

    Shan-Cheng Ren; Rui Chen; Ying-Hao Sun

    2013-01-01

    Prostate cancer (PCa) research in China has been on a rocketing trend in recent years.The first genome-wide association study (GWAS)in China identified two new PCa risk associated single nucleotide polymorphisms (SNPs).Next generation sequencing is beginning to be used,yielding novel findings:gene fusions,long non-coding RNAs and other variations.Mechanisms of PCa progression have been illustrated while various diagnosis biomarkers have been investigated extensively.Personalized therapy based on genetic factors,nano-medicine and traditional Chinese medicine has been the focus of experimental therapeutic research for PCa.This review intends to shed light upon the recent progress in PCa research in China and points out the possible breakthroughs in the future.

  15. The Cancer Prevention and Control Research Network

    Directory of Open Access Journals (Sweden)

    Jeffrey R. Harris, MD, MPH, MBA

    2005-01-01

    Full Text Available The Cancer Prevention and Control Research Network is a national network recently established to focus on developing new interventions and disseminating and translating proven interventions into practice to reduce cancer burden and disparities, especially among minority and medically underserved populations. Jointly funded by the Centers for Disease Control and Prevention and the National Cancer Institute, the Cancer Prevention and Control Research Network consists of sites administered through Prevention Research Centers funded by the Centers for Disease Control and Prevention. The five sites are located in Kentucky, Massachusetts, South Carolina, Texas, Washington State, and West Virginia. The Cancer Prevention and Control Research Network’s intervention areas include primary prevention of cancer through healthy eating, physical activity, sun avoidance, tobacco control, and early detection of cancer through screening. The Cancer Prevention and Control Research Network uses the methods of community-based participatory research and seeks to build on the cancer-relevant systematic reviews of the Guide to Community Preventive Services. Initial foci for the Cancer Prevention and Control Research Network’s research work groups include projects to increase screening for breast, cervical, and colorectal cancers; to promote informed decision making for prostate cancer screening; and to validate educational materials developed for low-literacy populations.

  16. What's New In Eye Cancer Research and Treatment?

    Science.gov (United States)

    ... resources for eye cancer What’s new in eye cancer research and treatment? Many medical centers around the world ... Your Doctor After Treatment What`s New in Eye Cancer Research? Other Resources and References Cancer Information Cancer Basics ...

  17. What's New in Salivary Gland Cancer Research and Treatment?

    Science.gov (United States)

    ... salivary gland cancer What’s new in salivary gland cancer research and treatment? Medical centers throughout the world are ... Doctor After Treatment What`s New in Salivary Gland Cancer Research? Other Resources and References Cancer Information Cancer Basics ...

  18. Breast Cancer and the Environment Research Program

    Science.gov (United States)

    The Breast Cancer and the Environment Research Program supports a multidisciplinary network of scientists, clinicians, and community partners to examine the effects of environmental exposures that may predispose a woman to breast cancer throughout her life.

  19. Collaborations in Proteomics Research - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The National Cancer Institute (NCI), through the Office of Cancer Clinical Proteomics Research (OCCPR), has signed two Memorandums of Understanding (MOUs) in the sharing of proteomics reagents and protocols

  20. Applying Existing Reading Research : To Improve English Reading Comprehension in Icelandic Secondary Schools

    OpenAIRE

    Constance Lynne Clark 1961

    2015-01-01

    The purpose of this thesis was to examine research on collaborative reading models, the learning of strategies for improving reading comprehension for secondary students of English as a second or foreign language (hereafter referred to as the L2), and to provide intervention measures that target struggling readers before remedial recommendations become necessary. The particular focus draws from research of both native-speaking English language (L1) learners and L2 learners. Few studies are av...

  1. Forging a Link between Research and Pedagogy: A Holistic Framework for Evaluating Business English Materials

    Science.gov (United States)

    Chan, Clarice S. C.

    2009-01-01

    In the last two decades, a great deal of applied linguistics research has been conducted in different areas of business English. However, despite many highly relevant research findings, the interface between research and pedagogy remains weak. One reason behind this lack of interface is that research findings from different studies are rarely…

  2. The Education of English Language Learners: Research to Practice

    Science.gov (United States)

    Shatz, Marilyn, Ed.; Wilkinson, Louise C., Ed.

    2010-01-01

    This comprehensive volume describes evidence-based strategies for supporting English language learners (ELLs) by promoting meaningful communication and language use across the curriculum. Leading experts explain how and why learning is different for ELLs and pinpoint specific best practices for the classroom, illustrated with vivid examples.…

  3. Spanish researchers’ perceived difficulty writing research articles for English-medium journals: the impact of proficiency in English versus publication experience

    Directory of Open Access Journals (Sweden)

    Ana I. Moreno

    2012-10-01

    Full Text Available Previous quantitative studies suggest that the burden researchers who use English as an additional language perceive when writing research articles (RAs for publication in English (as L2 is 24% greater than the burden they perceive when they write RAs for publication in their L1. It remains unclear precisely which aspects of research article (RA writing in English present these writers with the greatest challenge and just why they perceive this increase in difficulty. A structured questionnaire comprising thirty-seven questions about researchers’ publication experiences in scientific journals in English and in Spanish was designed and sent out to all (n = 8,794 Spanish postdoctoral researchers at one research-only institution and four universities in Spain, yielding responses from 1,717 researchers. Our first results show that the discussion is the section that is perceived as more difficult to write for English-medium journals, across the four broad knowledge areas in a way that cannot be fully explained by their lower level of proficiency in English (as L2. This article proposes the rhetorical transfer hypothesis as a possible explanation for their additional difficulty. Our results also reveal that their increased perceived difficulty writing RA discussions in English (as L2 does not decrease noticeably until Spanish researchers report high or very high levels of proficiency in English (as L2 for academic or general purposes or have published on average at least 37 RAs as corresponding author in English-medium journals over the last ten years. Implications for English for Academic Purposes (EAP research and pedagogy are discussed.

  4. Basic research on cancer related to radiation associated medical researches

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jong In; Hwang, Dae Yong; Bang, Ho Yoon [and others

    2000-12-01

    Basic Research on Cancer related to Radiation Associated Medical Researches including 1. Establishment of animal model of colorectal cancer liver metastasis and measurement of angiogenesis, 2. Tissue expression of Tie-1 and Tie-2 in human colorectal cancer, 3. Enhancement of G2/Mphase Cell Fraction by Adenovirus-mediated p53 Gene Transfer in Ovarian Cancer Cell Lines, 4. Clinical Characteristics of the patients with Non-B Non-C Hepatocellular Carcinoma and Frequency of HBV, HCV and TTV Viremia in these Patients, 5. Significance of serum iron and ferritin in patients with stomach cancer, 6. Telomerase assay for early detection of lung cancer, 7. Study on the Usefulness of Aldehyde dehydrogenase-2 Genotyping for Risk Group of Alcohol-related Cancer Screening, 8. Gene therapy using hepatoma specific promoter, 9. Study on the Influence of DNA repair gene, XRCC1 Genotypes on the Risk of Head and Neck Cancer were performed.

  5. Basic research on cancer related to radiation associated medical researches

    International Nuclear Information System (INIS)

    Basic Research on Cancer related to Radiation Associated Medical Researches including 1. Establishment of animal model of colorectal cancer liver metastasis and measurement of angiogenesis, 2. Tissue expression of Tie-1 and Tie-2 in human colorectal cancer, 3. Enhancement of G2/Mphase Cell Fraction by Adenovirus-mediated p53 Gene Transfer in Ovarian Cancer Cell Lines, 4. Clinical Characteristics of the patients with Non-B Non-C Hepatocellular Carcinoma and Frequency of HBV, HCV and TTV Viremia in these Patients, 5. Significance of serum iron and ferritin in patients with stomach cancer, 6. Telomerase assay for early detection of lung cancer, 7. Study on the Usefulness of Aldehyde dehydrogenase-2 Genotyping for Risk Group of Alcohol-related Cancer Screening, 8. Gene therapy using hepatoma specific promoter, 9. Study on the Influence of DNA repair gene, XRCC1 Genotypes on the Risk of Head and Neck Cancer were performed

  6. Metagenomics: A new horizon in cancer research

    OpenAIRE

    Joyita Banerjee; Neetu Mishra; Yogita Dhas

    2015-01-01

    Metagenomics has broadened the scope of targeting microbes responsible for inducing various types of cancers. About 16.1% of cancers are associated with microbial infection. Metagenomics is an equitable way of identifying and studying micro-organisms within their habitat. In cancer research, this approach has revolutionized the way of identifying, analyzing and targeting the microbial diversity present in the tissue specimens of cancer patients. The genomic analyses of these micro-organisms t...

  7. Genomic Datasets for Cancer Research

    Science.gov (United States)

    A variety of datasets from genome-wide association studies of cancer and other genotype-phenotype studies, including sequencing and molecular diagnostic assays, are available to approved investigators through the Extramural National Cancer Institute Data Access Committee.

  8. College English Students’ Autonomous Learning Motivation and Cultivation Model Research

    Institute of Scientific and Technical Information of China (English)

    王艳荣; 李娥

    2015-01-01

    Studying the autonomous learning motivation and excitation model can stimulate intrinsic motivation of foreign language learners,develop students self-management strategy evaluation are very necessary.The purpose of this paper is to give students the skills of listening and speaking for their autonomous learning.Then study the cultivation and motivation of college English students autonomous learning,hoping to make students to learn autonomous learning and stimulate their motivation fully.

  9. Novel translational strategies in colorectal cancer research

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Defining translational research is still a complex task. In oncology, translational research implies using our basic knowledge learnt from in vitro and in vivo experiments to directly improve diagnostic tools and therapeutic approaches in cancer patients. Moreover, the better understanding of human cancer and its use to design more reliable tumor models and more accurate experimental systems also has to be considered a good example of translational research. The identification and characterization of new molecular markers and the discovery of novel targeted therapies are two main goals in colorectal cancer translational research. However, the straightforward translation of basic research findings, specifically into colorectal cancer treatment and vice versa is still underway. In the present paper, a summarized view of some of the new available approaches on colorectal cancer translational research is provided. Pros and cons are discussed for every approach exposed.

  10. Lysyl oxidase in cancer research

    DEFF Research Database (Denmark)

    Perryman, Lara; Erler, Janine Terra

    2014-01-01

    Metastasis is the main reason for cancer-associated deaths and therapies are desperately needed to target the progression of cancer. Lysyl oxidase (LOX) plays a pivotal role in cancer progression, including metastasis, and is therefore is an attractive therapeutic target. In this review we will...

  11. Preparing Palestinian Reflective English Language Teachers through Classroom Based Action Research

    Science.gov (United States)

    Dajani, Majida "Mohammed Yousef "

    2015-01-01

    This study aimed to describe the implementation of individual action research projects among some forty English language teachers distributed in thirty Palestinian schools in Ramallah and Qabatya districts-Palestine. It aimed to analyze the outcomes of the teachers' action research as part of a broader participatory action research project that is…

  12. An Action Research on Improving Non-English Majors' English Writing by "Basic Sentence Pattern Translation Drills"

    Science.gov (United States)

    He, Xiaoyu

    2016-01-01

    English writing plays an indispensible part in EFL (English as a Foreign Language) learning for Chinese students, which accounts for a high score in an English test in China. And it is also a comprehensive reflection of students' abilities in L2 application. However, most non-English majors in vocational and technical colleges have great trouble…

  13. Nutrition and Cancer Prevention Research Practicum | Division of Cancer Prevention

    Science.gov (United States)

    The Nutritional Science Research Group in the Division of Cancer Prevention at the National Cancer Institute, National Institutes of Health and the Department of Nutrition at the Clinical Center, National Institutes of Health are offering a one week educational opportunity in "Nutrition and Cancer Prevention Research" for individuals with a sustained commitment to nutrition and health promotion. This one-week intense learning session provides specialized instruction in the role of diet and bioactive food components as modifiers of cancer incidence and tumor behavior. |

  14. Research Networks Map | Division of Cancer Prevention

    Science.gov (United States)

    The Division of Cancer Prevention supports major scientific collaborations and research networks at more than 100 sites across the United States.  Five Major Programs' sites are shown on this map. | The Division of Cancer Prevention supports major scientific collaborations and research networks at more than 100 sites across the United States.

  15. What's New in Bone Cancer Research and Treatment?

    Science.gov (United States)

    ... resources for bone cancer What’s new in bone cancer research and treatment? Research on bone cancer is now ... Your Doctor After Treatment What`s New in Bone Cancer Research? AdditionalResources Other Resources and References Cancer Information Cancer ...

  16. Research On: Motivation to Learn English among College Students in Sudan

    Science.gov (United States)

    Humaida, Ibrahim Abdelrahim Ibrahim

    2012-01-01

    This research was conducted to achieve the following objectives: to examine motivation to learn English language among students of faculty of arts, Islamic University-Sudan, to find out if there were significant statistical differences on motivation scores related to both student level and age. To pursue these objectives, the researcher used the…

  17. Beyond Learning Styles: Brain-Based Research and English Language Learners

    Science.gov (United States)

    Lombardi, Judy

    2008-01-01

    In this article, the author discusses ways in which teachers can implement brain-based research in teaching English language learners (ELLs). Teachers of ELLs can draw on recently developed brain-based research applied to other learners, in addition to their considerations of multicultural strategies, learning styles, and diverse needs. Equipped…

  18. Data mining in cancer research

    OpenAIRE

    Paulo J G Lisboa; Vellido Alcacena, Alfredo; Tagliaferri, Roberto; Napolitano, Francesco; Ceccarelli, Michelle; Martín Guerrero, José D.; Biganzoli, Elia

    2010-01-01

    This article is not intended as a comprehensive survey of data mining applications in cancer. Rather, it provides starting points for further, more targeted, literature searches, by embarking on a guided tour of computational intelligence applications in cancer medicine, structured in increasing order of the physical scales of biological processes.

  19. Novel translational strategies in colorectal cancer research

    OpenAIRE

    Gil-Bazo, Ignacio

    2007-01-01

    Defining translational research is still a complex task. In oncology, translational research implies using our basic knowledge learnt from in vitro and in vivo experiments to directly improve diagnostic tools and therapeutic approaches in cancer patients. Moreover, the better understanding of human cancer and its use to design more reliable tumor models and more accurate experimental systems also has to be considered a good example of translational research. The identification and characteriz...

  20. Action research to promote medical students' motivation in an English for Specific Purposes class.

    OpenAIRE

    Afsaneh Dehnad; Hayedeh Nasser

    2014-01-01

    Action research is an attempt to seek immediate solutions to the problems experienced in educational settings. In this type of research, teachers are the researchers who intend to make instant reforms to develop, and improve their teaching styles and reflect on pedagogical practices. The purpose of this study was to conduct an action research to tackle the problem of students' low motivation in English classes at the medical school of Iran University of Medical Sciences in fall 2010. Particip...

  1. Databases and QSAR for Cancer Research

    Directory of Open Access Journals (Sweden)

    Adeel Malik

    2006-01-01

    Full Text Available In this review, we take a survey of bioinformatics databases and quantitative structure-activity relationship studies reported in published literature. Databases from the most general to special cancer-related ones have been included. Most commonly used methods of structure-based analysis of molecules have been reviewed, along with some case studies where they have been used in cancer research. This article is expected to be of use for general bioinformatics researchers interested in cancer and will also provide an update to those who have been actively pursuing this field of research.

  2. Milestones in Cancer Research and Discovery

    Science.gov (United States)

    During the past 250 years, we have witnessed many landmark discoveries in our efforts to make progress against cancer, an affliction known to humanity for thousands of years. This timeline shows a few key milestones in the history of cancer research.

  3. Research Areas: Causes of Cancer

    Science.gov (United States)

    Understanding the exposures and risk factors that cause cancer, as well as the genetic abnormalities associated with the disease, has helped us to reduce certain exposures and to ameliorate their harmful effects.

  4. How to Read English Research Articles: A Case Study of Graduate Students Majoring in Information Systems

    Directory of Open Access Journals (Sweden)

    - Krismiyati

    2014-05-01

    Full Text Available Reading research articles in English will be a special challenge for those students who speak English as a foreign language (EFL. EFL graduate students will require a specific method for helping them to cope with the articles they have to read. This study tries to offer a method for helping them to read, understand, and analyze English articles easier. This study employs evaluation and trialing. It is accompanied by pre and post surveys that will give information about the condition of the students before and after the method is implemented. This study involved graduate students majoring in Information Systems at Satya Wacana Christian University. It is expected that the method proposed will help the students to know exactly what they need to read and focus on when they read a research article so that they can use their time more efficiently and effectively.

  5. DCB - Cancer Immunology, Hematology, and Etiology Research

    Science.gov (United States)

    Part of NCI’s Division of Cancer Biology’s research portfolio, studies supported include the characterization of basic mechanisms relevant to anti-tumor immune responses and hematologic malignancies.

  6. NIH Research Leads to Cervical Cancer Vaccine

    Science.gov (United States)

    ... Transmitted Diseases NIH Research Leads to Cervical Cancer Vaccine Past Issues / Fall 2008 Table of Contents For ... Douglas Lowy (left) and John Schiller developed the vaccine to prevent HPV infection in women, the cause ...

  7. The Tentative Research on Cultural Identity in China English and on How to Teach Chinese Culture in College English Class

    Institute of Scientific and Technical Information of China (English)

    鲁巧巧

    2013-01-01

      With the rapid pace of globalization,English has become the global language or international language which is playing all increasingly important role in international communication. Inevitably involved in this process,China has experienced all up⁃ surge of English learning. The author drawing support from the theories in sociolinguistics and intercultural communication, And analysis the sets of teaching materials used in college English class, for example, The New Horizon College English. The unbal⁃ anced proportion of Chinese culture input to western culture input in textbooks is one of the main reasons why Chinese college stu⁃ dents are incompetent in expressing Chinese culture in English.

  8. Metagenomics: A new horizon in cancer research

    Directory of Open Access Journals (Sweden)

    Joyita Banerjee

    2015-09-01

    Full Text Available Metagenomics has broadened the scope of targeting microbes responsible for inducing various types of cancers. About 16.1% of cancers are associated with microbial infection. Metagenomics is an equitable way of identifying and studying micro-organisms within their habitat. In cancer research, this approach has revolutionized the way of identifying, analyzing and targeting the microbial diversity present in the tissue specimens of cancer patients. The genomic analyses of these micro-organisms through next generation sequencing techniques invariably facilitate in recognizing the microbial population in biopsies and their evolutionary relationships with each other. In this review an attempt has been made to generate current metagenomic view on cancer microbiota. Different types of micro-organisms have been found to be linked to various types of cancers, thus, contributing significantly in understanding the disease at molecular level.

  9. Design Based Research Methodology for Teaching with Technology in English

    Science.gov (United States)

    Jetnikoff, Anita

    2015-01-01

    Design based research (DBR) is an appropriate method for small scale educational research projects involving collaboration between teachers, students and researchers. It is particularly useful in collaborative projects where an intervention is implemented and evaluated in a grounded context. The intervention can be technological, or a new program…

  10. Cancer systems biology: signal processing for cancer research

    Institute of Scientific and Technical Information of China (English)

    Olli Yli-Harja; Antti Ylip(a)(a); Matti Nykter; Wei Zhang

    2011-01-01

    In this editorial we introduce the research paradigms of signal processing in the era of systems biology. Signal processing is a field of science traditionally focused on modeling electronic and communications systems, but recently it has turned to biological applications with astounding results. The essence of signal processing is to describe the natural world by mathematical models and then, based on these models, develop efficient computational tools for solving engineering problems. Here, we underline, with examples, the endless possibilities which arise when the battle-hardened tools of engineering are applied to solve the problems that have tormented cancer researchers. Based on this approach, a new field has emerged, called cancer systems biology. Despite its short history, cancer systems biology has already produced several success stories tackling previously impracticable problems. Perhaps most importantly, it has been accepted as an integral part of the major endeavors of cancer research, such as analyzing the genomic and epigenomic data produced by The Cancer Genome Atlas (TCGA) project. Finally, we show that signal processing and cancer research, two fields that are seemingly distant from each other, have merged into a field that is indeed more than the sum of its parts.

  11. What's New in Prostate Cancer Research and Treatment?

    Science.gov (United States)

    ... SEE A LIST » What’s new in prostate cancer research? Previous Topic Second cancers after prostate cancer Next Topic Additional resources for prostate cancer What’s new in prostate cancer research? Research into the causes , prevention , detection , and treatment ...

  12. Healthy Eating for Life English as a second language curriculum: Primary outcomes from a nutrition education intervention targeting cancer risk reduction

    OpenAIRE

    Duncan, Lindsay R; Martinez, Josefa L; Rivers, Susan E.; Latimer, Amy E.; Bertoli, Michelle C; Domingo, Samantha; Salovey, Peter

    2012-01-01

    We conducted a pre–post feasibility trial of Healthy Eating for Life, a theory-based, multimedia English as a second language curriculum that integrates content about healthy nutrition into an English language learning program to decrease cancer health disparities. Teachers in 20 English as a second language classrooms delivered Healthy Eating for Life to 286 adult English as a second language students over one semester. Postintervention data are available for 227 students. The results indica...

  13. Review of Developments in Research into English as a Lingua Franca

    Science.gov (United States)

    Jenkins, Jennifer; Cogo, Alessia; Dewey, Martin

    2011-01-01

    We begin by considering how the recent phenomenon of English as a Lingua Franca (henceforth ELF) fits in with the older notion of lingua francas in general as well as with older versions of ELF. We then explore the beginnings of ELF in its modern manifestation, including the earliest ELF research, and tackle the thorny issue of defining ELF. After…

  14. A Constructive Teaching Model in Learning Research Concept for English Language Teaching Students

    Science.gov (United States)

    Anwar, Khoirul

    2015-01-01

    This is a study to focus on analyzing the use of constructive teaching method toward the students' motivation in learning content subject of Introduction to Research of English Language Teaching. By using a mix-method of qualitative and quantitative analysis, the data are collected by using questionnaire and classroom observation. The…

  15. Thinking Allowed: Managing Innovation in English Language Education--A Research Agenda

    Science.gov (United States)

    Waters, Alan

    2014-01-01

    In Waters (2009), the author attempted to capture the "state of the art" in theorising, practice, and research activity about the management of innovation in English language education (ELE). In this article, he reprises a number of areas in that review, to identify where the field would benefit from further enquiry about how to…

  16. English Language Teaching Management Research in Post-Compulsory Contexts: Still "Crawling Out"?

    Science.gov (United States)

    Walker, John

    2011-01-01

    This paper explores the field of post-compulsory English Language Teaching (ELT) management research, enquiring into its identity, legitimacy and development, by identifying and discussing issues, problems, and controversies. It reviews the nature of the ELT sector as a predominantly commercial educational service with a significant role in "inner…

  17. Australians from a Non-English Speaking Background with Intellectual Disability: The Importance of Research

    Science.gov (United States)

    Brolan, Claire E.; Gomez, Miriam Taylor; Lennox, Nicholas G.; Ware, Robert S.

    2013-01-01

    The authors review available data on Australians from a non-English speaking background (NESB) with intellectual disability (ID). They find that intellectual disability in the Australian NESB community has received limited attention in terms of both qualitative and quantitative research. The existing literature is over 10 years old and is relevant…

  18. Study on Lexical Cohesion in English and Persian Research Articles (A Comparative Study)

    Science.gov (United States)

    Mirzapour, Fatemeh; Ahmadi, Maryam

    2011-01-01

    The present study aims to analyze comparatively English and Persian research articles (Linguistics, Literature, and Library and Information disciplines) in terms of number and degree of utilization of sub-types of lexical cohesion in order to appreciate textualization processes in the two languages concerned. The study analyzes 60 research…

  19. Investigating Move Structure of English Applied Linguistics Research Article Discussions Published in International and Thai Journals

    Science.gov (United States)

    Amnuai, Wirada; Wannaruk, Anchalee

    2013-01-01

    This study investigates the rhetorical move structure of English applied linguistic research article Discussions published in Thai and international journals. Two corpora comprising of 30 Thai Discussions and 30 international Discussions were analyzed using Yang & Allison's (2003) move model. Based on the analysis, both similarities and…

  20. The Effect of the Research Assessment Exercise on Organisational Culture in English Universities: Collegiality versus Managerialism

    Science.gov (United States)

    Yokoyama, Keiko

    2006-01-01

    The purpose of the study is to identify the effect of the research assessment exercise (RAE) on the balance between collegiality and managerialism in English universities. The article examines the institutional strategies for the 2001 RAE and its effect on organisational culture, identifying change in governance, management and leadership in…

  1. A Review of Research on Effective Community Programs for English Language Learners

    Science.gov (United States)

    Tellez, Kip; Waxman, Hersh C.

    2010-01-01

    This article synthesized current research on effective communities for English Language Learners (ELLs). The findings are discussed under the following categories: parents, community resources, and peers. The results of the review indicate that parenting programs are effective, but they must be carefully developed and often require specific…

  2. Ideologies "of" English Language Teaching in Iranian Academic Research: Mainstream, Alternative, and Beyond

    Science.gov (United States)

    Mirhosseini, Seyyed-Abdolhamid; Ghafar Samar, Reza

    2015-01-01

    Mainstream trends of English language teaching (ELT) are predominantly constructed within the epistemological boundaries shaped by the traditional conceptions of linguistics, learning, and teaching as well as positivist research methodology. What tends to be overshadowed by such conceptions is the underlying foundational belief structure of ELT…

  3. TCGA researchers identify 4 subtypes of stomach cancer

    Science.gov (United States)

    Stomach cancers fall into four distinct molecular subtypes, researchers with The Cancer Genome Atlas (TCGA) Network have found. Scientists report that this discovery could change how researchers think about developing treatments for stomach cancer, also c

  4. What's New in Liver Cancer Research and Treatment?

    Science.gov (United States)

    ... resources for liver cancer What`s new in liver cancer research and treatment? Because there are only a few ... or treat hepatitis infections before they cause liver cancers. Research into developing a vaccine to prevent hepatitis C ...

  5. Infectious Agents and Cancer Epidemiology Research Webinar Series

    Science.gov (United States)

    Infectious Agents and Cancer Epidemiology Research Webinar Series highlights emerging and cutting-edge research related to infection-associated cancers, shares scientific knowledge about technologies and methods, and fosters cross-disciplinary discussions on infectious agents and cancer epidemiology.

  6. Research Timeline: Dictionary Use by English Language Learners

    Science.gov (United States)

    Nesi, Hilary

    2014-01-01

    The history of research into dictionary use tends to be characterised by small-scale studies undertaken in a variety of different contexts, rather than larger-scale, longer-term funded projects. The research conducted by dictionary publishers is not generally made public, because of its commercial sensitivity, yet because dictionary production is…

  7. Radiation related basic cancer research

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seung Hoon; Yoo, Young Do; Hong, Seok Il [and others

    2000-04-01

    We studied the mechanism of radiation-induced apoptosis, the factors involved signaling, and the establishment of radiation-resistant cell lines in this study. During the TGF beta-stimulated epithelial mesenchymal transition(EMT), actin rearrangement occurred first and fibronectin matrix assembly followed. These two events were considered independent since cytochalasin-D did not inhibit TGF stimulated matrix assembly and fibronectin supplementation did not induce EMT. During EMT, alpha 5 beta 1 integrin and alpha v integrin have increased but MMP activation was not accompanied, which suggest that induction of extracellular matrix and activation of integrins may be main contributor for the EMT. Serum depriving induced apoptosis of HUVECs was prevented by vascular endothelial growth factor(VEGF) and PMA. The apoptosis prevention by VEGF and PMA were conformed by DNA fragmentation assay. The p53 expression level was down regulated by VEGF and PMA compared with serum deprived HUVECs. However, VEGF and PMA induces c-Myc expression level on these cells. We made the 5 radiation-resistant clones from breast, lung and cervical cancer cells. More than 70%, 100% and 50% increased resistance was detected in breast cancer cells, lung cancer cells, and cervical cells, respectively. We carried out differential display-PCR to clone the radiation-resistant genes. 9 out of 10 genes were analyzed their sequence.

  8. Radiation related basic cancer research

    International Nuclear Information System (INIS)

    We studied the mechanism of radiation-induced apoptosis, the factors involved signaling, and the establishment of radiation-resistant cell lines in this study. During the TGF beta-stimulated epithelial mesenchymal transition(EMT), actin rearrangement occurred first and fibronectin matrix assembly followed. These two events were considered independent since cytochalasin-D did not inhibit TGF stimulated matrix assembly and fibronectin supplementation did not induce EMT. During EMT, alpha 5 beta 1 integrin and alpha v integrin have increased but MMP activation was not accompanied, which suggest that induction of extracellular matrix and activation of integrins may be main contributor for the EMT. Serum depriving induced apoptosis of HUVECs was prevented by vascular endothelial growth factor(VEGF) and PMA. The apoptosis prevention by VEGF and PMA were conformed by DNA fragmentation assay. The p53 expression level was down regulated by VEGF and PMA compared with serum deprived HUVECs. However, VEGF and PMA induces c-Myc expression level on these cells. We made the 5 radiation-resistant clones from breast, lung and cervical cancer cells. More than 70%, 100% and 50% increased resistance was detected in breast cancer cells, lung cancer cells, and cervical cells, respectively. We carried out differential display-PCR to clone the radiation-resistant genes. 9 out of 10 genes were analyzed their sequence

  9. The Use of Abbreviations in English-Medium Astrophysics Research Paper Titles: A Problematic Issue

    Directory of Open Access Journals (Sweden)

    David I. Méndez

    2015-06-01

    Full Text Available In this study, we carry out a qualitative and quantitative analysis of abbreviations in 300 randomly collected research paper titles published in the most prestigious European and US-based Astrophysics journals written in English. Our main results show that the process of shortening words and groups of words is one of the most characteristic and recurrent features in Astrophysics research paper titling construction. In spite of the convenience of abbreviations as a mechanism for word-formation, some of them may pose certain difficulties of understanding and/or misinterpretation because of their specificity, ambiguity, or overlapping. To overcome these difficulties, we propose a series of options which with no doubt would lead to a better interaction among the different branches of Astrophysics in particular and of science in general and would definitely improve how research is currently performed and communicated.Keywords: Abbreviations; Astrophysics; English; Research Papers

  10. Diet and cancer: future etiologic research.

    Science.gov (United States)

    Schatzkin, A; Dorgan, J; Swanson, C; Potischman, N

    1995-01-01

    In light of several credible diet and cancer hypotheses, we suggest strategies for advancing our understanding in this area. Two conceptual approaches can be taken in defining dietary exposure: the decompositional approach focuses on specific nutrients and other chemical constituents of food, whereas the integrative approach emphasizes the action of whole foods or food patterns (cuisines). Diet-cancer hypotheses can be organized according to this conceptual framework. We review four types of scientific investigation available to us for advancing the diet and cancer field: metabolic (clinical nutrition) studies; animal studies; observational epidemiologic investigations; and clinical trials. Each of these designs has its strengths and limitations. Observational epidemiologic studies and trials have the particular advantage of examining explicit cancer end points in humans. Results from metabolic and animal research, however, can complement the findings from epidemiologic studies and trials. Finally, we briefly review strategies for evaluating promising hypotheses linking diet to cancers of the large bowel, lung, breast, and prostate. PMID:8741779

  11. Antiproton radiation found effective in cancer research

    CERN Multimedia

    2003-01-01

    "An international collaboration of scientists has completed the first ever antiproton beam experiments designed to reveal the biological effectiveness of antiproton radiation in terminating cells used for cancer research...PBar Labs assembled the collaboration at CERN (European Organization for Nuclear Research in Geneva) to perform the measurements" (1 page).

  12. A Quantitative and Comparative Research on Chinese and English Numerical Phrases

    OpenAIRE

    Peijun Chen

    2010-01-01

    Numerical phases have rich cultural connotations and connect closely with culture. Along with the extension of China’s reform and opening up policy, cross-cultural communication tends to be wider. The comparative research on cross-cultural languages is very important. Because of different cultural backgrounds, the cultural connotations of Chinese and English numerical phases are quite different. This paper tries to make a comparative research on the cultural connotations of numerical phases (...

  13. About the Breast and Gynecologic Cancer Research Group | Division of Cancer Prevention

    Science.gov (United States)

    The Breast and Gynecologic Cancer Research Group conducts and fosters the development of research on the prevention and early detection of breast cancer, cervix and human papillomavirus (HPV)-related cancers, endometrial cancers, ovarian cancers, and precursor conditions related to these cancers. |

  14. Integrative computational biology for cancer research

    OpenAIRE

    Fortney, Kristen; Jurisica, Igor

    2011-01-01

    Over the past two decades, high-throughput (HTP) technologies such as microarrays and mass spectrometry have fundamentally changed clinical cancer research. They have revealed novel molecular markers of cancer subtypes, metastasis, and drug sensitivity and resistance. Some have been translated into the clinic as tools for early disease diagnosis, prognosis, and individualized treatment and response monitoring. Despite these successes, many challenges remain: HTP platforms are often noisy and ...

  15. Prostate Cancer Research Trial Helps John Spencer Treat His Cancer | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... this page please turn Javascript on. Feature: Prostate Cancer Prostate Cancer Research Trial Helps John Spencer Treat His Cancer ... because of timely detection and treatment of his prostate cancer. He participated in an NIH-sponsored clinical trial. ...

  16. What's New in Pancreatic Cancer Research and Treatment?

    Science.gov (United States)

    ... SEE A LIST » What’s new in pancreatic cancer research? Previous Topic Living as a pancreatic cancer survivor Next Topic Additional resources for pancreatic cancer What’s new in pancreatic cancer research? Research into the causes , diagnosis , and treatment of ...

  17. The research of computer multimedia assistant in college English listening

    Science.gov (United States)

    Zhang, Qian

    2012-04-01

    With the technology development of network information, there exists more and more seriously questions to our education. Computer multimedia application breaks the traditional foreign language teaching and brings new challenges and opportunities for the education. Through the multiple media application, the teaching process is full of animation, image, voice, and characters. This can improve the learning initiative and objective with great development of learning efficiency. During the traditional foreign language teaching, people use characters learning. However, through this method, the theory performance is good but the practical application is low. During the long time computer multimedia application in the foreign language teaching, many teachers still have prejudice. Therefore, the method is not obtaining the effect. After all the above, the research has significant meaning for improving the teaching quality of foreign language.

  18. A professional development scheme for non-native speaking teachers of English from the Arab world: an action research study

    OpenAIRE

    Rabi, Sally A

    2013-01-01

    Following an action research framework, my research investigates professional development for English Language teachers in the Arab World, who are non-native speakers of English themselves. The thesis has five chapters: Literature Review, Critical Contexts, Methodology of the Study, Data Analysis and Presentation, and finally the Discussion and Findings of the research. The Literature Review covers works relevant to the area of the study in relation to existing teacher practices, te...

  19. Institutional shared resources and translational cancer research.

    Science.gov (United States)

    De Paoli, Paolo

    2009-01-01

    The development and maintenance of adequate shared infrastructures is considered a major goal for academic centers promoting translational research programs. Among infrastructures favoring translational research, centralized facilities characterized by shared, multidisciplinary use of expensive laboratory instrumentation, or by complex computer hardware and software and/or by high professional skills are necessary to maintain or improve institutional scientific competitiveness. The success or failure of a shared resource program also depends on the choice of appropriate institutional policies and requires an effective institutional governance regarding decisions on staffing, existence and composition of advisory committees, policies and of defined mechanisms of reporting, budgeting and financial support of each resource. Shared Resources represent a widely diffused model to sustain cancer research; in fact, web sites from an impressive number of research Institutes and Universities in the U.S. contain pages dedicated to the SR that have been established in each Center, making a complete view of the situation impossible. However, a nation-wide overview of how Cancer Centers develop SR programs is available on the web site for NCI-designated Cancer Centers in the U.S., while in Europe, information is available for individual Cancer centers. This article will briefly summarize the institutional policies, the organizational needs, the characteristics, scientific aims, and future developments of SRs necessary to develop effective translational research programs in oncology.In fact, the physical build-up of SRs per se is not sufficient for the successful translation of biomedical research. Appropriate policies to improve the academic culture in collaboration, the availability of educational programs for translational investigators, the existence of administrative facilitations for translational research and an efficient organization supporting clinical trial recruitment

  20. Institutional shared resources and translational cancer research

    Directory of Open Access Journals (Sweden)

    De Paoli Paolo

    2009-06-01

    Full Text Available Abstract The development and maintenance of adequate shared infrastructures is considered a major goal for academic centers promoting translational research programs. Among infrastructures favoring translational research, centralized facilities characterized by shared, multidisciplinary use of expensive laboratory instrumentation, or by complex computer hardware and software and/or by high professional skills are necessary to maintain or improve institutional scientific competitiveness. The success or failure of a shared resource program also depends on the choice of appropriate institutional policies and requires an effective institutional governance regarding decisions on staffing, existence and composition of advisory committees, policies and of defined mechanisms of reporting, budgeting and financial support of each resource. Shared Resources represent a widely diffused model to sustain cancer research; in fact, web sites from an impressive number of research Institutes and Universities in the U.S. contain pages dedicated to the SR that have been established in each Center, making a complete view of the situation impossible. However, a nation-wide overview of how Cancer Centers develop SR programs is available on the web site for NCI-designated Cancer Centers in the U.S., while in Europe, information is available for individual Cancer centers. This article will briefly summarize the institutional policies, the organizational needs, the characteristics, scientific aims, and future developments of SRs necessary to develop effective translational research programs in oncology. In fact, the physical build-up of SRs per se is not sufficient for the successful translation of biomedical research. Appropriate policies to improve the academic culture in collaboration, the availability of educational programs for translational investigators, the existence of administrative facilitations for translational research and an efficient organization

  1. Researching powerful and powerless styles: Professional mock interviews in an English course

    OpenAIRE

    Pérez Sabater, Carmen; Montero Fleta, Maria Begoña; Pérez Sabater, Mª Luisa

    2014-01-01

    The study we present forms part of an ongoing study on the introduction of the Common European Framework of Reference for Languages (CEFR) in tertiary education. Our research aims at promoting the adequate use of workplace language by analysing the ability of non-native speakers of English to differentiate speech styles. Special attention has been devoted to the adequate use of powerful and powerless language in mock job interviews. © 2013 The Authors. Published by Elsevier Ltd. O...

  2. Review of developments in research into English as a Lingua Franca

    OpenAIRE

    Jenkins, Jennifer; Cogo, Alessia; Dewey, Martin

    2011-01-01

    We begin by considering how the recent phenomenon of English as a Lingua Franca (henceforth ELF) fits in with the older notion of lingua francas in general as well as with older versions of ELF. We then explore the beginnings of ELF in its modern manifestation, including the earliest ELF research, and tackle the thorny issue of defining ELF. After discussing the main locations and domains in which ELF research has been carried out to date, we move on to examining research into three linguisti...

  3. Impact of proteomics on bladder cancer research

    DEFF Research Database (Denmark)

    Celis, Julio E; Gromova, Irina; Moreira, José Manuel Alfonso;

    2004-01-01

    Detecting bladder cancer at an early stage and predicting how a tumor will behave and act in response to therapy, as well as the identification of new targets for therapeutic intervention, are among the main areas of research that will benefit from the current explosion in the number of powerful ...

  4. Motivating Subjects: Data Sharing in Cancer Research

    OpenAIRE

    Tucker, Jennifer

    2009-01-01

    This dissertation explores motivation in decision-making and action in science and technology, through the lens of a case study: scientific data sharing in cancer research. The research begins with the premise that motivation and emotion are key elements of what it means to be human, and consequently, are important variables in how individuals make decisions and take action. At the same time, institutional controls and social messaging send a variety of signals intended to motivate specific ...

  5. Selected National Cancer Institute Breast Cancer Research Topics | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... For Breast Cancer Selected National Cancer Institute Breast Cancer Research Topics Past Issues / Summer 2014 Table of Contents ... Trials www.cancer.gov/clinicaltrials/Taking-Part-in-Cancer-Treatment-Research-Studies MedlinePlus tutorial www.nlm.nih.gov/medlineplus/ ...

  6. Why is Physics Important to Cancer Research?

    Science.gov (United States)

    Barker, Anna D.

    Cancer is increasingly described as a ''disease of the genes'', and while the genome (in fact all of the ``omes'') are important information molecules that drive aspects of the initiation and progression of cancer, they are far from the whole story. Cancer is an extraordinarily complex system (in fact a complex of systems) that occurs in three-dimensional space, across multiple scales - and often over extended periods of time. The most challenging issues that plague the cancer field such as metastasis, cellular heterogeneity and resistance to therapy are in large part more rationally explained in the context of the physics of these systems vs. genomics. For example, the biology of metastasis has been studied extensively for decades with little progress. Metastatic disease depends on cells acquiring (or expressing innate information) new properties that enable and sustain their ability to migrate to distant sites. Developing a fundamental understanding of key cancer processes ranging from metastasis to immunotherapeutic responses requires that physicists (and mathematicians and engineers) be integrated into a new generation of cancer research - period! The presentation will focus on those areas where physics is essential - and the how's and whose of achieving the integration required.

  7. Data Collected in 1959 by English Research Vessels at Serial and Surface Hydrographic Stations (NODC Accession 6900852)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The present volume contains data collected in 1959 by English research vessels at serial and surface hydrographic stations. The data list are preceded by a number...

  8. What's New in Esophageal Cancer Research and Treatment?

    Science.gov (United States)

    ... Download Printable Version [PDF] » What`s New in Esophagus Cancer Research? TOPICS Document Topics GO » SEE A LIST » What’s ... Your Doctor After Treatment What`s New in Esophagus Cancer Research? Other Resources and References Cancer Information Cancer Basics ...

  9. Translating basic research in cancer patient care

    Directory of Open Access Journals (Sweden)

    Marcello Maugeri-Saccà

    2011-01-01

    Full Text Available With the advent of molecular targeted therapies and the development of high-throughput biotechnologies, it has become evident that progress in cancer research is largely due to the creation of multidisciplinary teams able to plan clinical trials supported by appropriate molecular hypotheses. These efforts have culminated in the identification and validation of biomarkers predictive of response, as well as in the generation of more accurate prognostic tools. The identification of cancer stem cells has provided further insights into mechanisms of cancer, and many studies have tried to translate this biological notion into prognostic and predictive information. In this regard, new agents targeting key stemness-related pathways have entered the clinical development, and preliminary data suggested an encouraging antitumor activity.

  10. Application of Metabolomics in Thyroid Cancer Research

    Directory of Open Access Journals (Sweden)

    Anna Wojakowska

    2015-01-01

    Full Text Available Thyroid cancer is the most common endocrine malignancy with four major types distinguished on the basis of histopathological features: papillary, follicular, medullary, and anaplastic. Classification of thyroid cancer is the primary step in the assessment of prognosis and selection of the treatment. However, in some cases, cytological and histological patterns are inconclusive; hence, classification based on histopathology could be supported by molecular biomarkers, including markers identified with the use of high-throughput “omics” techniques. Beside genomics, transcriptomics, and proteomics, metabolomic approach emerges as the most downstream attitude reflecting phenotypic changes and alterations in pathophysiological states of biological systems. Metabolomics using mass spectrometry and magnetic resonance spectroscopy techniques allows qualitative and quantitative profiling of small molecules present in biological systems. This approach can be applied to reveal metabolic differences between different types of thyroid cancer and to identify new potential candidates for molecular biomarkers. In this review, we consider current results concerning application of metabolomics in the field of thyroid cancer research. Recent studies show that metabolomics can provide significant information about the discrimination between different types of thyroid lesions. In the near future, one could expect a further progress in thyroid cancer metabolomics leading to development of molecular markers and improvement of the tumor types classification and diagnosis.

  11. What's New in Colorectal Cancer Research and Treatment?

    Science.gov (United States)

    ... escape to close saved articles window. My Saved Articles » My ACS ... in colorectal cancer research? Research is always going on in the area of colorectal cancer. Scientists are looking for causes and ways to prevent ...

  12. AN EMPIRICAL RESEARCH APPLICATION OF CLT TO ENGLISH GRAMMAR TEACHING IN SENIOR MIDDLE SCHOOL%AN EMPIRICAL RESEARCH APPLICATION OF CLT TO ENGLISH GRAMMAR TEACHING IN SENIOR MIDDLE SCHOOL

    Institute of Scientific and Technical Information of China (English)

    Zhang Caihong

    2011-01-01

    During the course of English teaching in middle schools, grammar teaching is always a focus argued about by English researchers and English teachers- -Is it necessary to teach grammar? Which approach or method td grammar teaching may help the students improve the effects of learning a foreign language and enhance their ability to use the foreign language? In view of this circumstance, the author does an experiment on teaching grammar in the framework of CLT to prove whether CLT is really more effective for students to master grammar knowledge than traditional method and whether CLT can improve the students' ability to express themselves freely, properly and fluently.

  13. A Genre Analysis of English and Iranian Research Articles Abstracts in Applied Linguistics and Mathematics

    Directory of Open Access Journals (Sweden)

    Biook Behnam

    2014-09-01

    Full Text Available In recent years, genre studies have attracted the attention of many researchers. The aim of the present study was to observe the differences in generic structure of abstract written by English native and non-native (Iranian students in two disciplines of mathematics and applied linguistics. To this end, twenty native English students’ abstract texts from each discipline and the same number of non-native (Iranian ones were selected. In this study, Hyland’s (2000 five‐move model was used to identify the rhetorical structure of the four sets of texts. After analyzing each text, the main moves were extracted and the frequencies of each one were calculated and compared. The cross-disciplinary and cross‐linguistic analyses reveal that linguistics abstracts follow a conventional scheme, but mathematics abstracts in these two languages do not exhibit the usual norms in terms of moves. Besides, greater difference in move structure is seen across languages in mathematics. The findings of the study have some pedagogical implications for academic writing courses for graduate students, especially students from non-English backgrounds in order to facilitate their successful acculturation into these disciplinary communities.Keywords: Genre Analysis, mathematics, applied linguistics

  14. Next Generation Distributed Computing for Cancer Research

    OpenAIRE

    Pankaj Agarwal; Kouros Owzar

    2015-01-01

    Advances in next generation sequencing (NGS) and mass spectrometry (MS) technologies have provided many new opportunities and angles for extending the scope of translational cancer research while creating tremendous challenges in data management and analysis. The resulting informatics challenge is invariably not amenable to the use of traditional computing models. Recent advances in scalable computing and associated infrastructure, particularly distributed computing for Big Data, can provide ...

  15. About the Lung and Upper Aerodigestive Cancer Research Group | Division of Cancer Prevention

    Science.gov (United States)

    The Lung and Upper Aerodigestive Cancer Research Group conducts and supports research on the prevention and early detection of lung and head and neck cancers, as well as new approaches to clinical prevention studies including cancer immunoprevention.Phase 0/I/II Cancer Prevention Clinical Trials ProgramThe group jointly administers the Phase 0/I/II Cancer Prevention Clinical Trials Program evaluating new agents, surrogate biomarkers, and technologies to identify premalignant lesions, and related cancers.  |

  16. Basic and technical research on lung cancer

    International Nuclear Information System (INIS)

    In association with clinical study of carbon beam therapy for lung cancer, the basic research for lung cancer and the patients with this disease has been carried out for the past 10 years. With regard to lung damage by the carbon beams, firstly pulmonary function was measured and analyzed for the patients with stage I non-small cell lung cancer. Force expiratory volume in 1 second (FVE 1.0) and TLC (total lung capacity) was found to be reduced significantly at 6 and 12 months after therapy but the reduction rate was a little, which can support the safety of this treatment modality. Secondly, the regional lung damage by the beams was investigated by using correct fusion of CT images with carbon beam dose distribution, diagnostic follow-up CT images and blood flow and ventilation spect images. It demonstrated the graded decrease blood flow by dose and the compensatory increase of blood flow in the adjacent lobe of lung unexposed to irradiation. On the other hand, the biological study of carbon beam effects on lung cancer cells and tumors line was conducted. Firstly, by using 7 or 4 human lung cancer cell line, the radiosensitivity of carbon beams was compared with that of photons by different histological patterns. It was found that there was no essential difference in the sensitivity pattern for lung cancer histology between the carbon beams and photons though the former doubled the later in power. Secondly, by using IA cell lines among them, the dynamic of clonogenic cells (clonogen) in a nude tumor and the changes in its morphology following irradiation was investigated, clarifying that the clonogen proliferating under anoxic or hypoxic conditions played a pivotal role for tumor regrowth and stemmed from the different clone which had been genetically selected and developed under these conditions. The finding of clonogen becomes one of the evidence supporting the superiority of a single-dose radiotherapy to fractionated radiotherapy. (author)

  17. Improving Cancer Care Through Nursing Research.

    Science.gov (United States)

    Mayer, Deborah K

    2015-09-01

    Nursing research and nurse researchers have been an integral and significant part of the Oncology Nursing Society's (ONS's) history, as evidenced by the development of the Nursing Research Committee within a few years of ONS's establishment. Ruth McCorkle, PhD, RN, FAAN, was the committee's first chairperson in 1979. This was followed by the creation of the Advanced Nursing Research Special Interest Group in 1989 under the leadership of Jean Brown, PhD, RN, FAAN. ONS also began to recognize nurse researchers in 1994 by creating the annual ONS Distinguished Researcher Award to recognize the contributions of a member who has conducted or promoted research that has enhanced the science and practice of oncology nursing. The list of recipients and of their work is impressive and reflects the wide range of our practice areas (see http://bit.ly/1MTC5cp for the recipient list). In addition, the ONS Foundation began funding research in 1981 and has distributed more than $24 million in research grants, research fellowships, and other scholarships, lectures, public education projects, and career development awards (ONS Foundation, 2015). And, in 2006, the Putting Evidence Into Practice resource was unveiled, which provides evidence-based intervention reviews for the 20 most common problems experienced by patients with cancer and their caregivers (www.ons
.org/practice-resources/pep)
. PMID:26302272

  18. The cancer translational research informatics platform

    Directory of Open Access Journals (Sweden)

    Johnson Kimberly

    2008-12-01

    Full Text Available Abstract Background Despite the pressing need for the creation of applications that facilitate the aggregation of clinical and molecular data, most current applications are proprietary and lack the necessary compliance with standards that would allow for cross-institutional data exchange. In line with its mission of accelerating research discoveries and improving patient outcomes by linking networks of researchers, physicians, and patients focused on cancer research, caBIG (cancer Biomedical Informatics Grid™ has sponsored the creation of the caTRIP (Cancer Translational Research Informatics Platform tool, with the purpose of aggregating clinical and molecular data in a repository that is user-friendly, easily accessible, as well as compliant with regulatory requirements of privacy and security. Results caTRIP has been developed as an N-tier architecture, with three primary tiers: domain services, the distributed query engine, and the graphical user interface, primarily making use of the caGrid infrastructure to ensure compatibility with other tools currently developed by caBIG. The application interface was designed so that users can construct queries using either the Simple Interface via drop-down menus or the Advanced Interface for more sophisticated searching strategies to using drag-and-drop. Furthermore, the application addresses the security concerns of authentication, authorization, and delegation, as well as an automated honest broker service for deidentifying data. Conclusion Currently being deployed at Duke University and a few other centers, we expect that caTRIP will make a significant contribution to further the development of translational research through the facilitation of its data exchange and storage processes.

  19. A Proposal for Critical-Pragmatic Pedagogical Approaches to English for Research Publication Purposes

    Directory of Open Access Journals (Sweden)

    James Corcoran

    2016-03-01

    Full Text Available Despite the increasing demands on many multilingual scholars outside the centre(s of scientific knowledge production to publish their research in international scholarly journals, the support for such academic writing for publication is uneven at best. Existing English for research publication purposes (ERPP instruction typically aims to aid multilingual scholars in achieving genre-based expectations and/or navigating the submission and review process, but it often does not address the politics of English-language knowledge production. In this paper, informed by an empirical case study and a theory building perspective, we address the need for a sustained program of courses/workshops for multilingual scholars in the (semi- periphery and propose a means of operationalizing a critical-pragmatic approach to such course/workshop content. Our empirically-driven model is informed by the results of a recent case study investigation into an intensive ERPP intervention designed to address multilingual Spanish-speaking L1 scholars’ challenges with writing research articles for publication in indexed (Web of Science international scientific journals. Our model lays the groundwork for a more critical approach to ERPP pedagogy, one that attempts to attend more fully to the needs of multilingual scholars within an asymmetrical market of global knowledge production.

  20. Research status and funding trends of lung cancer biomarkers

    OpenAIRE

    Li, Cui; Hong, Wei

    2013-01-01

    Lung cancer is one of malignant tumors with the highest morbidity and mortality in the world. At present, research of early diagnosis, treatment, prognosis, and metastasis associated biomarkers is most active. This article reviewed the research status of lung cancer biomarkers and analyzed the funding situation in the field of lung cancer markers in recent 10 years in China and abroad, to provide a reference for the future basic and clinical translational research of lung cancer biomarkers.

  1. Evidence and research in rectal cancer

    International Nuclear Information System (INIS)

    The main evidences of epidemiology, diagnostic imaging, pathology, surgery, radiotherapy, chemotherapy and follow-up are reviewed to optimize the routine treatment of rectal cancer according to a multidisciplinary approach. This paper reports on the knowledge shared between different specialists involved in the design and management of the multidisciplinary ESTRO Teaching Course on Rectal Cancer. The scenario of ongoing research is also addressed. In this time of changing treatments, it clearly appears that a common standard for large heterogeneous patient groups have to be substituted by more individualised therapies based on clinical-pathological features and very soon on molecular and genetic markers. Only trained multidisciplinary teams can face this new challenge and tailor the treatments according to the best scientific evidence for each patient

  2. Adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations and breast cancer risk.

    Science.gov (United States)

    Harris, Holly R; Bergkvist, Leif; Wolk, Alicja

    2016-06-01

    The World Cancer Research Fund/American Association for Cancer Research (WCRF/AICR) has published eight nutrition-related recommendations for the prevention of cancer. However, few prospective studies have examined these recommendations by breast cancer hormone receptor subtype and only one case-control study has included the dietary supplements recommendation in their evaluation. We investigated whether adherence to the WCRF/AICR cancer prevention recommendations was associated with breast cancer incidence, overall and by hormone receptor subtype, in the Swedish Mammography Cohort. Among 31,514 primarily postmenopausal women diet and lifestyle factors were assessed with a self-administered food frequency questionnaire. A score was constructed based on adherence to the recommendations for body fatness, physical activity, energy density, plant foods, animal foods, alcoholic drinks and dietary supplements (score range 0-7). Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs). During 15 years of follow-up 1,388 cases of breast cancer were identified. Women who met six to seven recommendations had a 51% decreased risk of breast cancer compared to women meeting only zero to two recommendations (95% CI = 0.35-0.70). The association between each additional recommendation met and breast cancer risk was strongest for the ER-positive/PR-positive subtype (HR = 0.86; 95% CI = 0.79-0.94), while for the ER-negative/PR-negative subtype the individual recommendations regarding plant and animal foods were most strongly associated with reduced risk. Our findings support that adherence to the WCRF/AICR recommendations reduces breast cancer risk in a population of primarily postmenopausal women. Promoting these recommendations to the public could help reduce breast cancer incidence. PMID:26804371

  3. NCI Community Oncology Research Program Approved | Division of Cancer Prevention

    Science.gov (United States)

    On June 24, 2013, the National Cancer Institute (NCI) Board of Scientific Advisors approved the creation of the NCI Community Oncology Research Program (NCORP). NCORP will bring state-of-the art cancer prevention, control, treatment and imaging clinical trials, cancer care delivery research, and disparities studies to individuals in their own communities. |

  4. [Experience of stroke prevention-Enlightenment for cancer research].

    Science.gov (United States)

    You, Weicheng

    2015-08-01

    Cancer, stroke and heart diseases are most common causes of death. This paper summarized the experience of stroke prevention, which is an enlightenment for cancer research. In addition, this paper also described the progress of cancer epidemiological research, particular the primary and second preventions in China. PMID:26733022

  5. Getting research published internationally in English: An ethnographic account of a team of Finance Spanish scholars’ struggles

    Directory of Open Access Journals (Sweden)

    Pilar Mur Dueñas

    2012-10-01

    Full Text Available Intercultural text-based research has shown remarkable differences in the rhetorical structure and devices of research articles (RAs in different linguistic/cultural contexts of publication, including the Spanish local context and the English international context. However, not much attention has been paid to the research article (RA writing process, which can throw light into the publication practices of second language (L2 scholars in particular disciplinary fields and which can help unveil their main writing difficulties. In this paper I focus on the “text histories” of a team of Spanish researchers in the field of Finance who struggle to get their research articles published internationally in English. These text histories correspond to 24 papers drafted and (resubmitted over the past 5-6 years. The analysis focuses on the extent to which they aim to publish their RAs in English, how they cope with writing their texts in English, their success in such a task and the kind of negative comments included in the referee reports they receive. Results show that this team of L2 scholars almost exclusively write their RAs in English and aim at publishing them in English-medium international journals; for this demanding task, they draw on a number of strategies. They are partially successful in that they have managed to publish half of their RAs in the first site where they were submitted. Their manuscripts received a lot of negative comments; especially relevant is the inclusion of a high number of unspecific negative comments related to language or style in major revision reports. Looking into the writing process can be of great help to provide L2 scholars with useful guidelines on drafting their RAs in English for international publication and to gain an insight into the forces driving international publication in this context.

  6. About the Prostate and Urologic Cancer Research Group | Division of Cancer Prevention

    Science.gov (United States)

    The Prostate and Urologic Cancer Research Group conducts and supports research on prostate and bladder cancers, and new approaches to clinical prevention studies including cancer immunoprevention. The group develops, implements and monitors research efforts in chemoprevention, nutrition, genetic, and immunologic interventions, screening, early detection and other prevention strategies. |

  7. Aquatic invasive species: Lessons from cancer research

    Science.gov (United States)

    Sepulveda, Adam; Ray, Andrew; Al-Chokhachy, Robert K.; Muhlfeld, Clint C.; Gresswell, Robert E.; Gross, Jackson A.; Kershner, Jeffrey L.

    2014-01-01

    Aquatic invasive species are disrupting ecosystems with increasing frequency. Successful control of these invasions has been rare: Biologists and managers have few tools for fighting aquatic invaders. In contrast, the medical community has long worked to develop tools for preventing and fighting cancer. Its successes are marked by a coordinated research approach with multiple steps: prevention, early detection, diagnosis, treatment options and rehabilitation. The authors discuss how these steps can be applied to aquatic invasive species, such as the American bullfrog (Lithobates catesbeianus), in the Northern Rocky Mountain region of the United States, to expedite tool development and implementation along with achievement of biodiversity conservation goals.

  8. Cancer Research from Molecular Discovery to Global Health

    Science.gov (United States)

    A science writers' seminar to discuss the latest research in cancer genetics and global health efforts, including talks from leaders of NCI’s new centers of cancer genomics and global health will be held Dec. 13, 2011, at NCI.

  9. Progress through Collaboration - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The National Cancer Institute (NCI), through the Office of Cancer Clinical Proteomics Research (OCCPR), has signed two Memorandums of Understanding (MOUs) in the areas of sharing proteomics reagents and protocols and also in regulatory science.

  10. The Research on the Silence Phenomena of Students in College English Classroom Teaching

    Institute of Scientific and Technical Information of China (English)

    杨六兰

    2015-01-01

    This paper analyzes the reasons that resulted in silence phenomena in college English classroom teaching,and gives some feasible suggestions to break the classroom silence in English classroom teaching.

  11. Increasing Underrepresented Scientists in Cancer Research: The UCSD CURE Program

    OpenAIRE

    Alfred, Lawrence; Beerman, Paula R.; Tahir, Zunera; LaHousse, Sheila F.; Russell, Percy; Sadler, Georgia Robins

    2010-01-01

    The Moores UCSD Cancer Center’s Continuing Umbrella of Research Experiences program aims to increase the number of underrepresented students pursuing careers in cancer research, cancer care, and health disparities research. Participants receive 8 weeks of laboratory and classroom training during the summer followed by participation in research mentors’ laboratories. Of the 82 CURE students accrued (2002 and 2008), 91% persisted in science after 1 year. Of the 63 students eligible to graduate ...

  12. Mass Communication Researchers in Sweden. Swedish Mass Communication Research: Publications in English, French and German.

    Science.gov (United States)

    Carlsson, Ulla, Ed.

    This listing of researchers and publications in mass communications research in Sweden is integrated into a single list arranged by the name of the researchers and noting their publications (if any) in the appropriate languages. In addition to publications, information provided for each researcher includes title and academic degree, project,…

  13. Research on cancer diagnosis in Malaysia: current status.

    Science.gov (United States)

    Looi, L M; Zubaidah, Z; Cheah, P L; Cheong, S K; Gudum, H R; Iekhsan, O; Ikram, S I; Jamal, R; Mak, J W; Othman, N H; Puteri, J N; Rosline, H; Sabariah, A R; Seow, H F; Sharifah, N A

    2004-06-01

    Cancer is a major morbidity and mortality concern in Malaysia. Based on National Cancer Registry data, the Malaysian population is estimated to bear a cancer burden of about 40,000 new cases per year, and a cumulative lifetime risk of about 1:4. Cancer research in Malaysia has to consider needs relevant to our population, and resources constraints. Hence, funding bodies prioritise cancers of high prevalence, unique to our community and posing specific clinical problems. Cancer diagnosis is crucial to cancer management. While cancer diagnosis research largely aims at improvements in diagnostic information towards more appropriate therapy, it also impacts upon policy development and other areas of cancer management. The scope of cancer diagnosis upon which this paper is based, and their possible impact on other R&D areas, has been broadly categorized into: (1) identification of aetiological agents and their linkages to the development of precancer and cancer (impact on policy development, cancer prevention and treatment), (2) cancer biology and pathogenesis (impact on cancer prevention, treatment strategies and product development), (3) improvements in accuracy, sensitivity and specificity in cancer detection, monitoring and classification (impact on technology development) and (4) prognostic and predictive parameters (impact on treatment strategies). This paper is based on data collected by the Working Group on Cancer Diagnosis Research for the First National Conference on Cancer Research Coordination in April 2004. Data was collated from the databases of Institutions/Universities where the authors are employed, the Ministry of Science, Technology and Innovation (MOSTI) and targeted survey feedback from key cancer researchers. Under the 7th Malaysia Plan, 76 cancer projects were funded through the Intensified Research in Priority Areas (IRPA) scheme of MOSTI, amounting to almost RM15 million of grant money. 47(61.8%) of these projects were substantially in cancer

  14. Mandates, needs, equitable resources, and current research in English language teacher education: The case of Turkey

    Directory of Open Access Journals (Sweden)

    Saban Cepik

    2014-02-01

    Full Text Available Improving the quality of English language teacher education (ELTE programs has become a major point of consideration; however, such programmatic evaluations are markedly rare. This study utilizes both numeric and interpretive qualitative data in a blended research design. The study addresses, vis-à-vis current research in related fields: What is the current situation of the Turkish ELTE programs in terms of curriculum strength and faculty resources? How do the program directors and teacher candidates envision the situation of their programs in terms of curriculum strength and faculty resources? Data included 45 ELTE curricula, interviews with 24 program directors and pre-service teachers, documents, and test scores. Findings revealed several significant associations between school type (public/private and rank (low/high and the number of faculty with expertise in critical areas in the field. Qualitative critical evaluations suggest both perceptual matches and mismatches between program directors and teacher candidates regarding programmatic strengths and weaknesses.

  15. Cancer Prevention Health Services Research: An Emerging Field

    OpenAIRE

    Zhao, Hui; Tektiridis, Jennifer H.; Zhang, Ning; Chamberlain, Robert M.

    2012-01-01

    In October 2009, The University of Texas MD Anderson Cancer Center hosted a symposium, “Future Directions in Cancer Prevention and Control: Workforce Implications for Training, Practice, and Policy.” This article summarizes discussions and an Internet and literature review by the symposium's Health Services Infrastructure Working Group. We agree on the need for the recognition of Cancer Prevention Health Services Research (CP-HSR) as a unified research field. With advances in cancer screening...

  16. A Research on the Gain and Cost of Bilingual Teaching of Non-English-Oriented Courses

    Institute of Scientific and Technical Information of China (English)

    ZhangZongrang

    2004-01-01

    In accordance with the requirement of the Ministry of Education, many Universities and colleges have begun or are beginning to adopt bilingual teaching of non-English-oriented courses with course books in English. The pu~ is to improve students' learning and acquiring of the English language during the process of studying the subject courses, and make them

  17. Cancer Survivorship Research: A Review of the Literature and Summary of Current NCI-Designated Cancer Center Projects

    OpenAIRE

    Harrop, J. Phil; Dean, Julie A.; Paskett, Electra D.

    2011-01-01

    The number of cancer survivors and amount of cancer survivorship research has grown substantially during the past three decades. This paper provides a review of interventional and observational cancer survivorship research efforts as well as a summary of current cancer survivorship research projects being conducted by National Cancer Institute-designated cancer centers in an effort to identify areas that need further attention.

  18. Gaps in nutritional research among older adults with cancer

    Science.gov (United States)

    Presley, Carolyn J.; Dotan, Efrat; Soto-Perez-de-Celis, Enrique; Jatoi, Aminah; Mohile, Supriya G.; Won, Elizabeth; Alibhai, Shabbir; Kilari, Deepak; Harrison, Robert; Klepin, Heidi D.; Wildes, Tanya M.; Mustian, Karen; Demark-Wahnefried, Wendy

    2016-01-01

    Nutritional issues among older adults with cancer are an understudied area of research despite significant prognostic implications for treatment side effects, cancer-specific mortality, and overall survival. In May of 2015, the National Cancer Institute and the National Institute on Aging co-sponsored a conference focused on future directions in geriatric oncology research. Nutritional research among older adults with cancer was highlighted as a major area of concern as most nutritional cancer research has been conducted among younger adults, with limited evidence to guide the care of nutritional issues among older adults with cancer. Cancer diagnoses among older adults are increasing, and the care of the older adult with cancer is complicated due to multimorbidity, heterogeneous functional status, polypharmacy, deficits in cognitive and mental health, and several other non-cancer factors. Due to this complexity, nutritional needs are dynamic, multifaceted, and dependent on the clinical scenario. This manuscript outlines the proceedings of this conference including knowledge gaps and recommendations for future nutritional research among older adults with cancer. Three common clinical scenarios encountered by oncologists include (1) weight loss during anti-cancer therapy, (2) malnutrition during advanced disease, and (3) obesity during survivorship. In this manuscript, we provide a brief overview of relevant cancer literature within these three areas, knowledge gaps that exist, and recommendations for future research. PMID:27197919

  19. Gaps in nutritional research among older adults with cancer.

    Science.gov (United States)

    Presley, Carolyn J; Dotan, Efrat; Soto-Perez-de-Celis, Enrique; Jatoi, Aminah; Mohile, Supriya G; Won, Elizabeth; Alibhai, Shabbir; Kilari, Deepak; Harrison, Robert; Klepin, Heidi D; Wildes, Tanya M; Mustian, Karen; Demark-Wahnefried, Wendy

    2016-07-01

    Nutritional issues among older adults with cancer are an understudied area of research despite significant prognostic implications for treatment side effects, cancer-specific mortality, and overall survival. In May of 2015, the National Cancer Institute and the National Institute on Aging co-sponsored a conference focused on future directions in geriatric oncology research. Nutritional research among older adults with cancer was highlighted as a major area of concern as most nutritional cancer research has been conducted among younger adults, with limited evidence to guide the care of nutritional issues among older adults with cancer. Cancer diagnoses among older adults are increasing, and the care of the older adult with cancer is complicated due to multimorbidity, heterogeneous functional status, polypharmacy, deficits in cognitive and mental health, and several other non-cancer factors. Due to this complexity, nutritional needs are dynamic, multifaceted, and dependent on the clinical scenario. This manuscript outlines the proceedings of this conference including knowledge gaps and recommendations for future nutritional research among older adults with cancer. Three common clinical scenarios encountered by oncologists include (1) weight loss during anti-cancer therapy, (2) malnutrition during advanced disease, and (3) obesity during survivorship. In this manuscript, we provide a brief overview of relevant cancer literature within these three areas, knowledge gaps that exist, and recommendations for future research. PMID:27197919

  20. Introducing Business English

    NARCIS (Netherlands)

    Nickerson, C.; Planken, B.C.

    2015-01-01

    Introducing Business English provides a comprehensive overview of this topic, situating the concepts of Business English and English for Specific Business Purposes within the wider field of English for Special Purposes. This book draws on contemporary teaching and research contexts to demonstrate th

  1. Current Research and Management of Ovarian Cancer in China

    Institute of Scientific and Technical Information of China (English)

    GUMeijiao; SHIWei

    2002-01-01

    Ovarian cancer is ne of the most lethal malignant tumors in China,represents the third most common cancer after cervical cancer and endometrial cancer,and the first leading cause of death from hynaecological cancers.Due to the lack of effective screening strategies and the absence of symptoms in early-stage of disease,over 70% of patients present at an advanced stage.Despite the advances in surgical techniques and conventional chemotheraphy,the prognosis of ovarian cancer has not been improved significantly,and indeed the long-term survival for patients with advanced disease does not exceed 20%.The aetiology of ovarian cancer temains poorly understood.In China,the major focus of research is to clarify the mechanism underlying ovarian cancer,develop more effective life-saving diagnostic and therapeutic measures,and undertake more population-based studies.This article summarizes current research,diagnosis and management of ovarian cancer in China.

  2. Cancer Research Repository for Individuals With Cancer Diagnosis and High Risk Individuals.

    Science.gov (United States)

    2014-12-12

    Pancreatic Cancer; Thyroid Cancer; Lung Cancer; Esophageal Cancer; Thymus Cancer; Colon Cancer; Rectal Cancer; GIST; Anal Cancer; Bile Duct Cancer; Duodenal Cancer; Gallbladder Cancer; Gastric Cancer; Liver Cancer; Small Intestine Cancer; Peritoneal Surface Malignancies; Familial Adenomatous Polyposis; Lynch Syndrome; Bladder Cancer; Kidney Cancer; Penile Cancer; Prostate Cancer; Testicular Cancer; Ureter Cancer; Urethral Cancer; Hypopharyngeal Cancer; Laryngeal Cancer; Lip Cancer; Oral Cavity Cancer; Nasopharyngeal Cancer; Oropharyngeal Cancer; Paranasal Sinus Cancer; Nasal Cavity Cancer; Salivary Gland Cancer; Skin Cancer; CNS Tumor; CNS Cancer; Mesothelioma

  3. Understanding coping with cancer: How can qualitative research help?

    OpenAIRE

    Mahati Chittem

    2014-01-01

    Research in psycho-oncology investigates the psycho-social and emotional aspects of cancer and how this is related to health, well-being and overall patient care. Coping with cancer is a prime focus for researchers owing to its impact on patients′ psychological processing and life in general. Research so far has focused mainly on quantitative study designs such as questionnaires to examine the coping strategies used by cancer patients. However, in order to gain a rich and deep understanding o...

  4. Mouse models for cancer stem cell research

    OpenAIRE

    Cheng, Le; Ramesh, Anirudh V.; Flesken-Nikitin, Andrea; Choi, Jinhyang; Nikitin, Alexander Yu.

    2009-01-01

    Cancer stem cell concept assumes that cancers are mainly sustained by a small pool of neoplastic cells, known as cancer stem cells or tumor initiating cells, which are able to reproduce themselves and produce phenotypically heterogeneous cells with lesser tumorigenic potential. Cancer stem cells represent an appealing target for development of more selective and efficient therapies. However, direct testing of the cancer stem cell concept and assessment of its therapeutic implications in human...

  5. Prostate Cancer Stem Cells: Research Advances

    OpenAIRE

    Dagmara Jaworska; Wojciech Król; Ewelina Szliszka

    2015-01-01

    Cancer stem cells have been defined as cells within a tumor that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor. Experimental evidence showed that these highly tumorigenic cells might be responsible for initiation and progression of cancer into invasive and metastatic disease. Eradicating prostate cancer stem cells, the root of the problem, has been considered as a promising target in prostate cancer treatment to improve th...

  6. An Empirical Research on Developmental Assessment in Polytechnic Eng-lish Teaching

    Institute of Scientific and Technical Information of China (English)

    李正亚

    2015-01-01

    Developmental assessment, process-oriented and student-centered, aims at students’performance in learning process, and their development. The author of the paper conducted an empirical research of developmental assessment to her own students. By comparing the students’learning attitude, interest, motivation, strategies, performance and achievements in the experimental class with those in the controlled one, she found that developmental assessment had developed the students’comprehensive lan⁃guage competence, increased their grades in written examinations, especially in the final examination, and recorded their progress over time to have them a sense of accomplishment and become more self-confident, active, responsible and independent. There⁃fore, developmental assessment is an effective and reasonable assessment in the current polytechnic English teaching.

  7. Application and research of fuzzy clustering analysis algorithm under “micro-lecture” English teaching mode

    Directory of Open Access Journals (Sweden)

    Shi Ying

    2016-01-01

    Full Text Available The fuzzy clustering algorithm is to classify the data or indicators with a greater degree of similarity based on the principle of the same type of individuals possessing a greater similarity, and different types of individuals possessing differences, establish clear category boundaries, form any shape of relationship clusters in the solving process, and input the research indicators at random, in order to accurately analyze the significance of the indicators in the algorithm. The evaluation value of the clustering analysis can be obtained by the establishment of the fuzzy factor set based on the membership analysis, and the evaluation result can be analyzed through reference to the evaluation indicators of the fuzzy clustering analysis. The “micro-lecture” English teaching mode can be estimated and the analysis indicators can be rationally established based on the fuzzy clustering analysis algorithm, with better algorithm applicability.

  8. Canine cancer patients are included in translational research

    DEFF Research Database (Denmark)

    Børresen, Betina; Clausen, Malene Martini; Hansen, Anders Elias; Engelholm, Svend Aage; Kjær, Andreas; Kristensen, Annemarie Thuri; Zornhagen, Kamilla Westarp

    2014-01-01

    Cancer bearing dogs represent a unique clinical cancer model with a direct potential for accelerating translation into human patients. A research collaboration between the veterinary and human medical facilities at Copenhagen University and Rigshospitalet has taken offset in this. Canine cancer...

  9. Understanding coping with cancer: How can qualitative research help?

    Directory of Open Access Journals (Sweden)

    Mahati Chittem

    2014-01-01

    Full Text Available Research in psycho-oncology investigates the psycho-social and emotional aspects of cancer and how this is related to health, well-being and overall patient care. Coping with cancer is a prime focus for researchers owing to its impact on patients′ psychological processing and life in general. Research so far has focused mainly on quantitative study designs such as questionnaires to examine the coping strategies used by cancer patients. However, in order to gain a rich and deep understanding of the reasons, processes and types of strategies that patients use to deal with cancer, qualitative study designs are necessary. Few studies have used qualitative designs such as semi-structured interviews to explore coping with cancer. The current paper aims to review the suitability and benefits of using qualitative research designs to understand coping with cancer with the help of some key literature in psycho-oncology research.

  10. X ray imaging microscope for cancer research

    Science.gov (United States)

    Hoover, Richard B.; Shealy, David L.; Brinkley, B. R.; Baker, Phillip C.; Barbee, Troy W., Jr.; Walker, Arthur B. C., Jr.

    1991-01-01

    The NASA technology employed during the Stanford MSFC LLNL Rocket X Ray Spectroheliograph flight established that doubly reflecting, normal incidence multilayer optics can be designed, fabricated, and used for high resolution x ray imaging of the Sun. Technology developed as part of the MSFC X Ray Microscope program, showed that high quality, high resolution multilayer x ray imaging microscopes are feasible. Using technology developed at Stanford University and at the DOE Lawrence Livermore National Laboratory (LLNL), Troy W. Barbee, Jr. has fabricated multilayer coatings with near theoretical reflectivities and perfect bandpass matching for a new rocket borne solar observatory, the Multi-Spectral Solar Telescope Array (MSSTA). Advanced Flow Polishing has provided multilayer mirror substrates with sub-angstrom (rms) smoothnesss for the astronomical x ray telescopes and x ray microscopes. The combination of these important technological advancements has paved the way for the development of a Water Window Imaging X Ray Microscope for cancer research.

  11. Differential Network Analysis in Human Cancer Research

    Science.gov (United States)

    Gill, Ryan; Datta, Somnath; Datta, Susmita

    2016-01-01

    A complex disease like cancer is hardly caused by one gene or one protein singly. It is usually caused by the perturbation of the network formed by several genes or proteins. In the last decade several research teams have attempted to construct interaction maps of genes and proteins either experimentally or reverse engineer interaction maps using computational techniques. These networks were usually created under a certain condition such as an environmental condition, a particular disease, or a specific tissue type. Lately, however, there has been greater emphasis on finding the differential structure of the existing network topology under a novel condition or disease status to elucidate the perturbation in a biological system. In this review/tutorial article we briefly mention some of the research done in this area; we mainly illustrate the computational/statistical methods developed by our team in recent years for differential network analysis using publicly available gene expression data collected from a well known cancer study. This data includes a group of patients with acute lymphoblastic leukemia and a group with acute myeloid leukemia. In particular, we describe the statistical tests to detect the change in the network topology based on connectivity scores which measure the association or interaction between pairs of genes. The tests under various scores are applied to this data set to perform a differential network analysis on gene expression for human leukemia. We believe that, in the future, differential network analysis will be a standard way to view the changes in gene expression and protein expression data globally and these types of tests could be useful in analyzing the complex differential signatures. PMID:23530503

  12. English as Lingua Franca and English in Europe

    Science.gov (United States)

    Berns, Margie

    2009-01-01

    One of the objectives of English as Lingua Franca (ELF) researchers is an account of the unique features of English that they have found in the speech of European users of English. These features, it is argued, describe a variety of English which they label "English as Lingua Franca". The choice of this particular term is problematic because, as a…

  13. Research on Tactics of English Teaching to College Students by Modern Media Technology

    OpenAIRE

    Zhou Gang

    2016-01-01

    Modern colleges are faced with the dual pressures of university reform and international competition, how to overcome difficulties, to play the role of modern English teaching in colleges and colleges to enhance the core competitiveness of colleges, colleges and colleges modern English teaching problems to be solved. Based on the current situation of modern colleges in the premise of the Modern media platform fully demonstrated the characteristics and viability of the Modern media English tea...

  14. Application research of constructivism in the teaching of undergraduate English multimedia network

    Institute of Scientific and Technical Information of China (English)

    周红

    2015-01-01

    Constructivism is the frontier theory of cognitive psychology,constructivism has important and far-reaching influence to the college English teaching reform which is vigorously implemented in our country.Based on the introduce of constructivism theory,and the analysis of the college English multimedia network teaching status quo in present undergraduate course colleges and universities,this paper put forwards relevant suggestions on how to use constructivism theory in college English multimedia network teaching.

  15. Towards meeting the research needs of Australian cancer consumers

    Directory of Open Access Journals (Sweden)

    Saunders Carla

    2012-12-01

    Full Text Available Abstract Background There is a growing amount of literature to support the view that active involvement in research by consumers, especially informed and networked consumers, benefits the quality and direction of research itself, the research process and, most importantly, people affected by cancer. Our exploratory project focuses on identifying their priorities and developing a process to assess the research needs of Australian cancer consumers which may be useful beyond the cancer scenario. Methods This project was consumer initiated, developed and implemented, with the assistance of a leading Australian cancer consumer advocacy group, Cancer Voices NSW (CVN. Such direct involvement is unusual and ensures that the priorities identified, and the process itself, are not influenced by other interests, regardless how well-intentioned they may be. The processes established, and data collection via a workshop, followed by a questionnaire to confirm and prioritise findings, and comparison with a similar UK exercise, are detailed in this paper. Results Needs across five topic areas reflecting cancer control domains (prevention and risk; screening and diagnosis; treatment; survivorship; and end of life were identified. Cancer consumers high priority research needs were found to be: earlier diagnosis of metastatic cancers; the extent of use of best practice palliative care guidelines; identifying barriers to cancer risk behaviour change; and environmental, nutrition and lifestyle risk factors for people with cancer. A process for identifying consumers’ research priorities was developed and applied; this may be useful for further investigation in this under-studied area. Conclusion The findings provide a model for developing a consumer derived research agenda in Australia which can be used to inform the strategic direction of cancer research. Consumers have been seeking a workable method to achieve this and have worked in collaboration with a major

  16. English Language Education among Young Learners in East Asia: A Review of Current Research (2004-2014)

    Science.gov (United States)

    Butler, Yuko Goto

    2015-01-01

    The teaching of foreign languages to young learners is growing in popularity around the world. Research in this field, particularly of English as a second/foreign language education in East Asia, is a relatively new area of empirical inquiry, and it has the potential to make significant contributions to child second-language acquisition…

  17. Real Apprenticeships: Creating a Revolution in English Skills. Research by The Boston Consulting Group for the Sutton Trust

    Science.gov (United States)

    Nash, Ian; Jones, Sue

    2013-01-01

    This research by the Boston Consulting Group (BCG) for Sutton Trust examined the English education system and its apprenticeship programs. BCG reported that the UK is failing nearly half its young people by providing inadequate vocational opportunities. BSG presents key findings that include: (1) more than four in ten people have only low level…

  18. From One "I" to Another: Discursive Construction of Self-Representation in English and Castilian Spanish Research Articles

    Science.gov (United States)

    Sheldon, Elena

    2009-01-01

    The notion that academic writing is not only a conventional entity but also carries the representation of the writer has been supported by several researchers. Few studies have explored identity representation in language across two written cultures, such as English and Spanish, although Spanish might be a language of interest for non-native…

  19. Genre Analysis: Structural and Linguistic Evolution of the English-Medium Medical Research Article (1985-2004)

    Science.gov (United States)

    Li, Li-Juan; Ge, Guang-Chun

    2009-01-01

    This paper reports a corpus-based genre analysis of the structural and linguistic evolution of medical research articles (RAs) written in English. Towards that end, we analyzed the frequency of occurrence of the 11 moves identified by Nwogu (1997), of the three most frequently used verb tenses (simple past, simple present and present perfect) and…

  20. A Genre-based Analysis of English Research Article Abstracts and the Linguistic Feature of Personal Pronouns for Financial Economics

    Science.gov (United States)

    Ning, Zhen-ye

    2008-01-01

    This paper presents an empirical study of move structures and personal pronouns of fifty English RA (research article) abstracts based on the model of Bhatia (1990). It revealed that three other move patterns were ascertained besides ten out of the analyzed abstracts following his move order. The analysis of personal pronouns showed that…

  1. The Death of the Non-Native Speaker? English as a Lingua Franca in Business Communication: A Research Agenda

    Science.gov (United States)

    Nickerson, Catherine

    2015-01-01

    The impact of globalisation in the last 20 years has led to an overwhelming increase in the use of English as the medium through which many business people get their work done. As a result, the linguistic landscape within which we now operate as researchers and teachers has changed both rapidly and beyond all recognition. In the discussion below,…

  2. A Generic Analysis of English Research Article Abstracts and the Use of Modal Verbs for Financial Economics

    Science.gov (United States)

    Chen, Jie

    2010-01-01

    This paper is a generic study of schematic structures and the use of modal verbs of 50 English Research Article (RA) abstracts. With Bhatia's (1990) model as the framework, three other move patterns were obtained besides the normal move order. The density of modal verbs varies greatly from move to move with significant differences in the frequency…

  3. Review of Doctoral Research in English Language Education in the Philippines, Singapore and Malaysia (2007-2010)

    Science.gov (United States)

    Rubdy, Rani; Tupas, T. Ruanni F.; Villareal, Corazon D.; David, Maya Khemlani; Dumanig, Francisco Perlas

    2012-01-01

    This review highlights recent doctoral research in English language education and related areas completed between 2007 and 2010 in three countries in Southeast Asia: Singapore, Malaysia and the Philippines. Out of sixty dissertations initially chosen from major universities in these countries, five from the Philippines, four from Malaysia and…

  4. Integrating China English into College English Teaching

    Institute of Scientific and Technical Information of China (English)

    李永仙

    2016-01-01

    China English does exist, which is reconfirmed by salient linguistic features illustrated and documented by many research scholars. This paper explores some pedagogical implications addressing the issue of integrating China English into college English teaching to enhance learners' confidence and competence in cross-cultural communication.

  5. Next generation sequencing in cancer research and clinical application

    OpenAIRE

    Shyr, Derek; Liu, Qi

    2013-01-01

    The wide application of next-generation sequencing (NGS), mainly through whole genome, exome and transcriptome sequencing, provides a high-resolution and global view of the cancer genome. Coupled with powerful bioinformatics tools, NGS promises to revolutionize cancer research, diagnosis and therapy. In this paper, we review the recent advances in NGS-based cancer genomic research as well as clinical application, summarize the current integrative oncogenomic projects, resources and computatio...

  6. Educating Cancer Prevention Researchers in Emerging Biobehavioral Models: Lessons Learned

    OpenAIRE

    Correa-Fernández, Virmarie; Davila, Marivel; Kamrudin, Samira A.; Li, Dennis H.; Noor, Syed W.; Oluyomi, Abiodun O; Chang, Shine; Cameron, Carrie

    2011-01-01

    To increase the adoption of transdisciplinary research methods among future cancer prevention investigators, faculty members from The University of Texas MD Anderson Cancer Center developed a graduate-level course in biobehavioral methods in cancer prevention research. Two instructors paired by topic and area of expertise offered an hour-long lecture-based seminar every week for 15 weeks during the spring semester of 2010. Students and presenters both evaluated the overall course content and ...

  7. Prostate Cancer Stem Cells: Research Advances

    Directory of Open Access Journals (Sweden)

    Dagmara Jaworska

    2015-11-01

    Full Text Available Cancer stem cells have been defined as cells within a tumor that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor. Experimental evidence showed that these highly tumorigenic cells might be responsible for initiation and progression of cancer into invasive and metastatic disease. Eradicating prostate cancer stem cells, the root of the problem, has been considered as a promising target in prostate cancer treatment to improve the prognosis for patients with advanced stages of the disease.

  8. Adherence to the World Cancer Research Fund/American Institute for Cancer Research lifestyle recommendations in colorectal cancer survivors : Results of the PROFILES registry

    NARCIS (Netherlands)

    Winkels, Renate M; van Lee, Linde; Beijer, Sandra; Bours, Martijn J; van Duijnhoven, Fränzel J B; Geelen, Anouk; Hoedjes, Meeke; Mols, F.; de Vries, Jeanne; Weijenberg, Matty P; Kampman, Ellen

    2016-01-01

    We examined adherence to the eight The World Cancer Research Foundation/American Institute for Cancer Research (WCRF/AICR) recommendations on diet, physical activity, and body weight among colorectal cancer survivors, and whether adherence was associated with intention to eat healthy and with the ne

  9. Lung Cancer:Symptoms, Diagnosis, Treatments & Research | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... of this page please turn Javascript on. Feature: Lung Cancer Lung Cancer: Symptoms, Diagnosis, Treatments & Research Past Issues / Winter 2013 ... lung cancer are given intravenously or by mouth. Lung Cancer Research The large-scale National Lung Screening Trial, ...

  10. NIH Research: Cancers: A "Constellation" of Diseases | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... understanding affect how we think about cancer and cancer research? What we've learned can be grouped into ... some of the opportunities that you see in cancer research? The National Cancer Institute is ready to take ...

  11. Lung Cancer:Symptoms, Diagnosis, Treatments & Research | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... this page please turn Javascript on. Feature: Lung Cancer Lung Cancer: Symptoms, Diagnosis, Treatments & Research Past Issues / Winter 2013 ... lung cancer are given intravenously or by mouth. Lung Cancer Research The large-scale National Lung Screening Trial, ...

  12. The John Milner Nutrition and Cancer Prevention Research Practicum | Division of Cancer Prevention

    Science.gov (United States)

    The Nutritional Science Research Group in the Division of Cancer Prevention at the National Cancer Institute, National Institutes of Health and the Department of Nutrition at the Clinical Center, National Institutes of Health, and the US Department of Agriculture's Beltsville Human Nutrition Research Center are offering a one week educational opportunity in "Nutrition and Cancer Prevention Research" for individuals with a sustained commitment to nutrition and health promotion. |

  13. Advanced research on separating prostate cancer stem cells

    International Nuclear Information System (INIS)

    Prostate cancer is a common malignant tumor in male urinary system,and may easily develop into the hormone refractory prostate cancer which can hardly be cured. Recent studies had found that the prostate cancer stem cells may be the source of the prostate cancer's occurrence,development, metastasis and recurrence. The therapy targeting the prostate cancer stem cells may be the effective way to cure prostate cancer. But these cells is too low to be detected. The difficulty lies in the low separation efficiency of prostate cancer stem cell, so the effectively separating prostate cancer stem cells occupied the main position for the more in-depth research of prostate cancer stem cells. This paper reviews the research progress and existing problems on the several main separating methods of prostate cancer stem cells, includes the fluorescence activated cells sorting and magnetic activated cells sorting based on prostate cancer stem cell surface markers, the side-population sorting and serum-free medium sphere forming sorting based on prostate cancer stem cell's biology. (authors)

  14. Cancer Control Research Training for Native Researchers: A Model for Development of Additional Native Researcher Training Programs

    Science.gov (United States)

    Becker, Thomas M.; Dunn, Esther; Tom-Orme, Lillian; Joe, Jennie

    2005-01-01

    Several social and biological scientists who have Native status are engaged in productive research careers, but the encouragement that has been offered to Native students to formulate career goals devoted to cancer etiology or cancer control in Native peoples has had limited success. Hence, the Native Researchers' Cancer Control Training Program…

  15. Writing To Learn in English: A Synthesis of Research and Instructional Practices.

    Science.gov (United States)

    Allen, Sheilah

    Although English teachers have implicitly been aware of the functions of writing, they may not always have explored the ways writing can be used to enhance learning: learning of content, of skills, and of self. Arthur Applebee noted that English teachers were most likely to stress personal and imaginative experiences in their writing assignments,…

  16. A Research on Students' Needs for Follow-Up Curriculum of College English

    Science.gov (United States)

    Jin, Jie; Liu, Hengying; Zhang, Yan

    2015-01-01

    Increased universities and colleges offer the undergraduates with more follow-up courses with the further reform in college English education in China. An investigation on self-evaluation, difficulty, and willingness of undergraduates in learning English further was made in order to design more appropriate and adaptable follow-up courses. This…

  17. A Research on English Educational Problems among Intermediates in Middle School

    Institute of Scientific and Technical Information of China (English)

    兰凤英

    2015-01-01

    This paper mainly centers on the neglecting parts of English intermediates in middle school and presents their existing study problems. According to intermediates' characters and learning motivation, I will reveal reasons of these problems and come up with effective strategies from two aspects of English teachers and students.

  18. The Research of Difference between Boys and Girls during English Study

    Institute of Scientific and Technical Information of China (English)

    黄翠英

    2013-01-01

    With China's opening up and joining the World Trade Organization, more and more people are learning English. English study is very important for the learners, which involves a lot of factors, among which the learner's own factor is the most direct and main factor. In English teaching, we shouldn’t just pay our attention to the regular teaching principle of teaching stu-dents in accordance with their aptitude, and turn a blind eye to the non-intellectual factors of the learners. This thesis analyzes the differences and their reasons, and then puts forward some relevant countermeasures for eliminating the differences in English learning between boys and girls, in the hope of promoting them to make progress together in English study.

  19. Comparing written and oral measures of comprehension of cancer information by English-as-a-Second-Language Chinese immigrant women.

    Science.gov (United States)

    McWhirter, Jennifer; Todd, Laura; Hoffman-Goetz, Laurie

    2011-09-01

    The Short Test of Functional Health Literacy for Adults (S-TOFHLA) and Cloze test are commonly used tools to measure comprehension of health information (i.e., health literacy); however, little is known about their use in English-as-a-Second-Language (ESL) populations. In this study, we compared written (Cloze test) and oral (Teach Back) measures of colon cancer information comprehension among ESL Chinese immigrant women to Canada. Performances on colon cancer-specific measures were compared to a general measure of health literacy (S-TOFHLA). On the S-TOFHLA, Cloze, and Teach Back, respectively, the following percentage of participants had adequate comprehension: 62.1%, 14.8%, and 89.7%. Correlation between performance on the Cloze and Teach Back was significant albeit weakly so (r = 0.38, p = 0.04); performances on the S-TOFHLA and Teach Back were not correlated. Measures of health literacy skill that require written English language skills may not be appropriate for measuring understanding of health information for ESL populations. PMID:21445682

  20. English Water Meadows: historic relics or focus for environmental management and inter-disciplinary research?

    Science.gov (United States)

    Cook, Hadrian

    2015-04-01

    Irrigated water meadows are found across Europe, from southern Scandinavia to Spain and in the Alpine regions and Italy. While the practice of engineering 'floated' meadow land for deliberate irrigation on hillsides and floodplains is widespread and ancient, since about 1600 AD the practice was widely adopted on floodplains in southern England where they improved the timing and productivity of grazing land and produced hay crops. They also became a part of English consciousness through art and literature. To some, water meadows are a relic of an agrarian past, to others they are the object of a range of foci for conservation, education, sustainable grass production, community engagement and recent research suggests water returned from meadow irrigation is beneficial to river water quality. Historically floodplain 'bedwork' water meadows grew from, and were integral in, the farming system of 'Wessex' involving sheep which produced dung for arable land and later supporting dairy and beef production, as well as hay. Where systems remain, this is largely due to the whim of individuals, the outcome of agri-environmental schemes. Water meadows may be managed by public, voluntary or private sector bodies. What is needed is a fresh look at how land owners, or communities, might micro-target them for heritage, habitat and grassland management. There are therefore interesting questions concerning their future: Who might invest in their restoration and maintenance? How might they be integrated into commercial farming? Are they of sufficient interest to restore en masse to become (once more) a major feature of the English chalk stream valleys? Do they provide a way into academic and public perception, combining environmental science, history, cultural heritage and environmental management? How might restoration and management become vehicles for public engagement? While each of these questions represents a major topic for discussion, this paper is an attempt to consolidate

  1. Cancer complementary and alternative medicine research at the US National Cancer Institute.

    Science.gov (United States)

    Jia, Libin

    2012-05-01

    The United States National Cancer Institute (NCI) supports complementary and alternative medicine (CAM) research which includes different methods and practices (such as nutrition therapies) and other medical systems (such as Chinese medicine). In recent years, NCI has spent around $120 million each year on various CAM-related research projects on cancer prevention, treatment, symptom/side effect management and epidemiology. The categories of CAM research involved include nutritional therapeutics, pharmacological and biological treatments, mind-body interventions, manipulative and body based methods, alternative medical systems, exercise therapies, spiritual therapies and energy therapies on a range of types of cancer. The NCI Office of Cancer Complementary and Alternative Medicine (OCCAM) supports various intramural and extramural cancer CAM research projects. Examples of these cancer CAM projects are presented and discussed. In addition, OCCAM also supports international research projects. PMID:22241505

  2. English for communication in Bangladesh: baseline research to establish the pre-existing environment for the ‘English in Action’ project

    OpenAIRE

    Kirkwood, Adrian

    2013-01-01

    Although Bangladesh is largely monolingual, English is increasingly important for international communication. The English in Action project was established to enhance the use of English as a tool for better access to the world economy. Interventions in three sectors (primary education, secondary education and adult learning) aim to improve the teaching and learning of communicative English over a 9-year period. At the outset of the project a range of baseline studies was undertaken to collec...

  3. Next generation distributed computing for cancer research.

    Science.gov (United States)

    Agarwal, Pankaj; Owzar, Kouros

    2014-01-01

    Advances in next generation sequencing (NGS) and mass spectrometry (MS) technologies have provided many new opportunities and angles for extending the scope of translational cancer research while creating tremendous challenges in data management and analysis. The resulting informatics challenge is invariably not amenable to the use of traditional computing models. Recent advances in scalable computing and associated infrastructure, particularly distributed computing for Big Data, can provide solutions for addressing these challenges. In this review, the next generation of distributed computing technologies that can address these informatics problems is described from the perspective of three key components of a computational platform, namely computing, data storage and management, and networking. A broad overview of scalable computing is provided to set the context for a detailed description of Hadoop, a technology that is being rapidly adopted for large-scale distributed computing. A proof-of-concept Hadoop cluster, set up for performance benchmarking of NGS read alignment, is described as an example of how to work with Hadoop. Finally, Hadoop is compared with a number of other current technologies for distributed computing. PMID:25983539

  4. Towards discovery-driven translational research in breast cancer

    DEFF Research Database (Denmark)

    Celis, Julio E; Moreira, José M A; Gromova, Irina;

    2005-01-01

    , promise to have a major impact on the way breast cancer will be diagnosed, treated and monitored in the future. Here we present a brief report on long-term ongoing strategies at the Danish Centre for Translational Breast Cancer Research to search for markers for early detection and targets for therapeutic......Discovery-driven translational research in breast cancer is moving steadily from the study of cell lines to the analysis of clinically relevant samples that, together with the ever increasing number of novel and powerful technologies available within genomics, proteomics and functional genomics...... biology approach to fight breast cancer....

  5. Contributions to Cancer Research: Finding a Niche in Communication | Office of Cancer Genomics

    Science.gov (United States)

    This past July, I started a journey into the fields of communications and cancer research when I joined the Office of Cancer Genomics (OCG) as a fellow in the National Cancer Institute (NCI) Health Communications Internship Program (HCIP). Cancer genomics and working in an office were new and uncharted territory for me: before I came to OCG, I was finishing a Ph.D. in cell biology at Vanderbilt University in Dr. Matthew Tyska’s laboratory.

  6. feature - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    "Cancer is a disease of the genome," noted Lynda Chin, M.D., professor of dermatology, Harvard Medical School and Dana-Farber Cancer Institute. "And understanding the impact of genomic changes in the proteome is critically important for converting genomic knowledge into something that a clinician can use on their patients."

  7. Research on Promote the Attendance of Senior Students in English Class

    Institute of Scientific and Technical Information of China (English)

    余文君

    2014-01-01

    In traditional English class of China, the relationship between teacher and students is one-way communication. As a result, positive attendance in senior English class is not common. It is important to develop students' automatic learning and coop⁃eration learning abilities. However, the particularities of senior students in psychology and the background of college entrance ex⁃amination block the way of traditional teaching reform. From these aspects, this thesis comes up with corresponding advices to promote the attendance of senior English class.

  8. Clinical perspectives of cancer stem cell research in radiation oncology

    International Nuclear Information System (INIS)

    Radiotherapy has a proven potential to eradicate cancer stem cells which is reflected by its curative potential in many cancer types. Considerable progress has been made in identification and biological characterisation of cancer stem cells during the past years. Recent biological findings indicate significant inter- and intratumoural and functional heterogeneity of cancer stem cells and lead to more complex models which have potential implications for radiobiology and radiotherapy. Clinical evidence is emerging that biomarkers of cancer stem cells may be prognostic for the outcome of radiotherapy in some tumour entities. Perspectives of cancer stem cell based research for radiotherapy reviewed here include their radioresistance compared to the mass of non-cancer stem cells which form the bulk of all tumour cells, implications for image- and non-image based predictive bio-assays of the outcome of radiotherapy and a combination of novel systemic treatments with radiotherapy

  9. The Changing Landscape of Lung Cancer Research and Treatment

    Science.gov (United States)

    Along with the Lung Cancer Social Media (#LCSM) community, the National Cancer Institute will be co-hosting a lively and interactive Google Hangout on Air about the changing landscape of lung cancer research and treatment. During the chat, viewers will have the opportunity to pose questions to a panel of lung cancer experts including NCI's Dr. Shakun Malik, the head of thoracic oncology therapeutics, Roy S. Herbst, MD, PhD, Chief of Medical Oncology, Yale Cancer Center and Smilow Cancer Hospital at Yale-New Haven and David Tom Cooke MD FACS, Head, Section of General Thoracic Surgery University of California, Davis. You can also learn more and follow along on the #LCSM Chat page. The chat will be moderated by lung cancer advocate and #LCSM co-founder, Janet Freeman-Daily. To ask questions of our experts, simply use the #LCSM hashtag during the chat.

  10. Biomedical text mining and its applications in cancer research.

    Science.gov (United States)

    Zhu, Fei; Patumcharoenpol, Preecha; Zhang, Cheng; Yang, Yang; Chan, Jonathan; Meechai, Asawin; Vongsangnak, Wanwipa; Shen, Bairong

    2013-04-01

    Cancer is a malignant disease that has caused millions of human deaths. Its study has a long history of well over 100years. There have been an enormous number of publications on cancer research. This integrated but unstructured biomedical text is of great value for cancer diagnostics, treatment, and prevention. The immense body and rapid growth of biomedical text on cancer has led to the appearance of a large number of text mining techniques aimed at extracting novel knowledge from scientific text. Biomedical text mining on cancer research is computationally automatic and high-throughput in nature. However, it is error-prone due to the complexity of natural language processing. In this review, we introduce the basic concepts underlying text mining and examine some frequently used algorithms, tools, and data sets, as well as assessing how much these algorithms have been utilized. We then discuss the current state-of-the-art text mining applications in cancer research and we also provide some resources for cancer text mining. With the development of systems biology, researchers tend to understand complex biomedical systems from a systems biology viewpoint. Thus, the full utilization of text mining to facilitate cancer systems biology research is fast becoming a major concern. To address this issue, we describe the general workflow of text mining in cancer systems biology and each phase of the workflow. We hope that this review can (i) provide a useful overview of the current work of this field; (ii) help researchers to choose text mining tools and datasets; and (iii) highlight how to apply text mining to assist cancer systems biology research. PMID:23159498

  11. Future possibilities in the prevention of breast cancer: Fat and fiber and breast cancer research

    OpenAIRE

    Prentice, Ross L.

    2000-01-01

    The potential for a reduction in dietary fat or for an increase in dietary fiber to reduce breast cancer risk has been debated for some years. It is argued here that available research data, even though extensive, leave open hypotheses ranging from little or no potential to major public health potential for breast cancer prevention by means of these dietary maneuvers. Some elements of a research strategy for testing these and other dietary breast cancer prevention hypotheses are described.

  12. Towards research-tested smartphone applications for preventing breast cancer

    OpenAIRE

    Coughlin, Steven S; Thind, Herpreet; Liu, Benyuan; Wilson, Lt Col Candy

    2016-01-01

    Efforts to prevent breast cancer and other chronic illnesses have focused on promoting physical activity, healthy diet and nutrition, and avoidance of excessive alcohol consumption. Smartphone applications (apps) offer a low-cost, effective strategy for breast cancer prevention in women through behavioral change. However, there are currently no research-tested smartphone apps for breast cancer prevention that are suitable for women with varying levels of health literacy and eHealth literacy. ...

  13. Graphic Evolution Witness the Development of Lung Cancer Translational Research

    Directory of Open Access Journals (Sweden)

    Chao ZHANG

    2016-06-01

    Full Text Available Lung cancer treatment has altered from conventional chemotherapy to targeted treatment, which now has been turned to the immunotherapy. Translational research has played an irreplaceable role during this progression which graphic evolution has witnessed. The evolution has gone through forest plot, KM-curve, waterfall plot, spider plot and timeline-area, showing us the refining concept and gradual process of lung cancer treatment undergoing from community towards individual. Even though the latest immunotherapy is getting increasingly hot, the result isn’t quite expected. Meanwhile, the limitations of conventional treatment still exist which require further research. This article will primarily illustrate the development of translational research of lung cancer via the aspect of curve evolution and analysis some abortive clinical trials in lung cancer surgery for inspiring the next graphic style and lung cancer treatment.

  14. [Graphic Evolution Witness the Development of Lung Cancer Translational Research].

    Science.gov (United States)

    Zhang, Chao; Zhong, Wenzhao

    2016-06-20

    Lung cancer treatment has altered from conventional chemotherapy to targeted treatment, which now has been turned to the immunotherapy. Translational research has played an irreplaceable role during this progression which graphic evolution has witnessed. The evolution has gone through forest plot, KM-curve, waterfall plot, spider plot and timeline-area, showing us the refining concept and gradual process of lung cancer treatment undergoing from community towards individual. Even though the latest immunotherapy is getting increasingly hot, the result isn't quite expected. Meanwhile, the limitations of conventional treatment still exist which require further research. This article will primarily illustrate the development of translational research of lung cancer via the aspect of curve evolution and analysis some abortive clinical trials in lung cancer surgery for inspiring the next graphic style and lung cancer treatment. PMID:27335306

  15. A RESEARCH INTO THE EFFECT OF BACKGROUND KNOWLEDGE ON BUSINESS ENGLISH READING COMPREHENSION

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    With the arrival of the new millennium,the demand fortalented people with both professional knowledge and excellentlanguage abilities is getting stronger and stronger.For business major students,reading is paramount inBusiness English teaching and learning.And their reading abilityis often assessed by a text of reading comprehension.However,from my experience as a college teacher ofBusiness English,I have noticed some problems among studentswho have little knowledge of business.They seem to readBusiness English materials at a slower rate and with lessunderstanding than general English materials.Then there is the question:is Business English reading"simply"a problem of language competence? Or are there anyother more important factors?This article is an investigation into the effect of backgroundknowledge on Business English reading comprehension.Thestudy attempts to assess to what extent L2 readers might beaffected because of their lack of a background schematapresupposed by the author by comparing the test results of twopassages comparable in language lightness or heaviness.Morecomparable passages like these can be used in investigating intothe rival effects of background knowledge and linguisticcompetence.The implications of comprehension theory for L2pedagogy are discussed and suggestions for Business Englishteaching is put forward.

  16. Long-term oceanographic and ecological research in the Western English Channel.

    Science.gov (United States)

    Southward, Alan J; Langmead, Olivia; Hardman-Mountford, Nicholas J; Aiken, James; Boalch, Gerald T; Dando, Paul R; Genner, Martin J; Joint, Ian; Kendall, Michael A; Halliday, Nicholas C; Harris, Roger P; Leaper, Rebecca; Mieszkowska, Nova; Pingree, Robin D; Richardson, Anthony J; Sims, David W; Smith, Tania; Walne, Anthony W; Hawkins, Stephen J

    2005-01-01

    Long-term research in the western English Channel, undertaken by the marine laboratories in Plymouth, is described and details of survey methods, sites, and time series given in this chapter. Major findings are summarized and their limitations outlined. Current research, with recent reestablishment and expansion of many sampling programmes, is presented, and possible future approaches are indicated. These unique long-term data sets provide an environmental baseline for predicting complex ecological responses to local, regional, and global environmental change. Between 1888 and the present, investigations have been carried out into the physical, chemical, and biological components (ranging from plankton and fish to benthic and intertidal assemblages) of the western English Channel ecosystem. The Marine Biological Association of the United Kingdom has performed the main body of these observations. More recent contributions come from the Continuous Plankton Recorder Survey, now the Sir Alister Hardy Foundation for Ocean Science, dating from 1957; the Institute for Marine Environmental Research, from 1974 to 1987; and the Plymouth Marine Laboratory, which was formed by amalgamation of the Institute for Marine Environmental Research and part of the Marine Biological Association, from 1988. Together, these contributions constitute a unique data series-one of the longest and most comprehensive samplings of environmental and marine biological variables in the world. Since the termination of many of these time series in 1987-1988 during a reorganisation of UK marine research, there has been a resurgence of interest in long-term environmental change. Many programmes have been restarted and expanded with support from several agencies. The observations span significant periods of warming (1921-1961; 1985-present) and cooling (1962-1980). During these periods of change, the abundance of key species underwent dramatic shifts. The first period of warming saw changes in

  17. Abstracts Book of 2. Research Conference 'Thyroid cancer 2000'

    International Nuclear Information System (INIS)

    The sessions in the 2. Research Conference 'Thyroid cancer 2000' concerned molecular biology, epidemiology, pathology, advances in diagnosis and therapy of thyroid cancer. Some communications discussed molecular, biological and environmental risk factors (ionizing radiation, iodine deficiency). Radiobiological, dosimetric and radiological protection problems connected with iodine-131 therapy have been presented and discussed

  18. Psychological Issues in Cancer Genetics: Current Research and Future Priorities.

    Science.gov (United States)

    Hopwood, Penelope

    1997-01-01

    Data concerning the psychological impact of high risk of cancer are reviewed, including implications of genetic testing, breast screening,and accuracy of women's risk estimates. Work in progress on prophylactic mastectomy and chemoprevention is reviewed. Research on cancer families, and interventions and prevention strategies for high-risk…

  19. Biospecimen Core Resource - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The purpose of this notice is to notify the community that the National Cancer Institute's (NCI’s) Office of Cancer Clinical Proteomics Research (OCCPR) is seeking sources to establish a Biospecimen Core Resource (BCR), capable of receiving, qualifying, processing, and distributing annotated biospecimens.

  20. NCI Community Oncology Research Program (NCORP) | Division of Cancer Prevention

    Science.gov (United States)

    The NCI Community Oncology Research Program (NCORP) is a national network of cancer care investigators, providers, academia, and other organizations that care for diverse populations in health systems. View the list of publications from NCORP. | Clinical Trials network of cancer care professionals who care for diverse populations across the U.S.

  1. Strategy of research for cancer-chemoprevention

    International Nuclear Information System (INIS)

    It has been reported that environmental chemicals are important factors in terms of both development and prevention of human cancer. For prevention of human cancer, detection of early cancer and clinical trials at the early stage have been focused so far. Now, next main project will be investigation for prevention of cancer development itself. Chemoprevention of carcinogenesis, which means prevention of carcinogenesis by some chemical compounds, have been investigated extensively in a variety of organs, but in only one organ. However, from results of our studies, antioxidants such as BHA, responded differently to organs, and whole body investigation, not only one organ carcinogenesis, should be performed to investigate of chemoprevention. Furthermore, the mechanisms of action of chemoprevention and on which step of carcinogenesis does the chemopreventive compound prevent, such as initiation, promotion, progression or whole carcinogenesis steps should be discussed. We have developed a medium term bioassay system and multi-organ carcinogenesis system, which can be used for investigation of cancer chemoprevention. Using these systems, we have investigated dose response inhibitory effects of BHA and α-tocopherol by the medium-term bioassay system, and catechins in the green tea inhibit small intestinal carcinogenesis in the multi-organ carcinogenesis. It is important for prevent human cancer to find other candidates for chemopreventive agents using animal study. (author)

  2. Language through literature through language: An action research report on the English 100 course at the University of North West

    OpenAIRE

    Butler, I.

    2002-01-01

    In this article the writer surveys attitudes to the integration of language and literature in ESL/EFL teaching, noting the reservations that have been expressed about it in the past, and which still continue to linger in some quarters. Against this background he then describes the development and implementation of an integrated English syllabus at the University of North West, focusing on his current action research in teaching the first year modules. Using examples from the material he has d...

  3. Statistical study on cancer patients of cancer research hospital

    International Nuclear Information System (INIS)

    The total number of malignant neoplasms included on this study 7,787 cases(10.4%) among 74,928 cases for 2 years. On sex, females with 57.6% were much more than males with 42.4%. The highest proportion of cancer 50-59 age group. The most frequent primary site among males was found to be stomach with 36.2%, followed by liver(12.3%), lung(12.2%), esophagus(15.5%) and larynx(4.9%). In females, the first order was uterine cervix with 47.3%, followed most common type of morphology of malignant neoplasms was adenocarcinoma(39.0%) in males an squamous cell carcinoma(56.2%) in females. Among the cancer patients initially diagnosed in this hospital, the proportion of malignant neoplasms by the extent of disease was 4.6% for patient with carcinoma-in-situ, 76.3% for patients with localized involvement, 11.6% for patients with regional involvement and 7.5% for patients with distant involvement. Among,the cancer patients initially treatment in this hospital, the proportion of malignant neoplasms by the method of treatment was 19.0% for surgery, 27.7 for radiotherapy and 24.2% for chemotherapy. Among the cancer patients confirmed by medical records, 11.2% was traced more than 5 years. (Author)

  4. What's New in Ovarian Cancer Research and Treatment?

    Science.gov (United States)

    ... escape to close saved articles window. My Saved Articles » My ACS ... new in ovarian cancer research and treatment? Risk factors and causes Scientists continue to study the genes responsible for familial ...

  5. Researchers Find 8 Immune Genes in Aggressive Brain Cancer

    Science.gov (United States)

    ... 159031.html Researchers Find 8 Immune Genes in Aggressive Brain Cancer Discovery might eventually lead to better ... tissue samples from 170 people with a less aggressive type of brain tumor. This led to the ...

  6. Review of English Homework Research in Primary and Secondary Schooks in China%国内中小学英语家庭作业研究综述

    Institute of Scientific and Technical Information of China (English)

    贾炜茵; 关世民

    2014-01-01

    Researches on English homework in primary and secondary school in China mainly involve five parts: quantity and time of English homework, function of English homework, content and types of English homework, optimal strategies of English homework design, evaluation and feedback of English homework. These researches are a positive inspiration and provide a good reference for the study of English teaching in primary and secondary school. However, there still exist many problems in these studies. For example, there are more researches focusing on speciifc issues, but the researches and construc tion of basic theory of homework are not enough; there are more experience summary and theorefical researches, but quantitative reseaches are not enough.%国内对中小学英语家庭作业的研究涉及英语家庭作业的量、时间、功能、内容与类型、优化设计与布置和评价与反馈等研究。这些研究对中小学英语教学有积极的启发和借鉴意义,但也存在对具体问题的研究较多,对作业基本理论的研究和建构薄弱;经验总结和思辨研究多,量化研究少的问题。

  7. Application of English Euphemisms in English Teaching

    Institute of Scientific and Technical Information of China (English)

    ZENG Si-si

    2015-01-01

    With the rapid development of the society, people are expected to improve their language quality as well. So when people have to express something unpleasant, they prefer to employ some mild, implicit and euphemistic expressions. Meanwhile, an increasing number of scientists indulge themselves in studying English euphemisms from different perspectives, such as linguis⁃tics, pragmatics, and psychology and so on. English Euphemisms applied in class can not only help create a relaxing and lively at⁃mosphere but also protect the students’self-esteem and stimulate their interests in English. However, the researches on the ef⁃fects of applying English euphemisms in English class are few. Therefore, Based on Face-saving Theory, this paper intends to highlight the importance of applying English euphemisms in English teaching.

  8. The Continuing Umbrella of Research Experiences (CURE): A Model for Training Underserved Scientists in Cancer Research

    OpenAIRE

    Franco, Idalid; Bailey, LeeAnn O.; Bakos, Alexis D.; Springfield, Sanya A.

    2010-01-01

    Mentoring is a critical aspect of research and training; and the adoption of a successful mentoring model for guiding researchers through the educational pipeline is lacking. The Continuing Umbrella of Research Experiences (CURE) program was established in the Comprehensive Minority Biomedical Branch; which is part of the National Cancer Institute. This program offers unique training and career development opportunities to enhance diversity in cancer research. The CURE initiative focuses on b...

  9. Advances in Research on Circulating Tumor Cells in Lung Cancer

    Directory of Open Access Journals (Sweden)

    Yingjian SONG

    2012-10-01

    Full Text Available Metastatic and recurrent tumors have been identified as the leading attribute to the lung cancer deaths. Cancer research has demonstrated the critical role circulating tumor cells (CTCs play in the metastatic spread of carcinomas and the recurrence of lung cancer. The rapid advancement of technology in targeted therapy resolves the embarrassing situation for those late-stage patients whose tumor tissues cannot be obtained. CTCs, as a substitute for the tumor tissues, represent a decisive tool to the cancer treatment strategy. Thus, CTCs exert a fundamental role in the early detection of micro-metastasis, assisting in diagnosis, prognosis and monitoring of the recurrent tumors, and subsequently choosing an individualized approach for the therapeutic treatment. This article will review the advances, which have been made in the research area of CTCs with the aid of its applications in cancer therapy.

  10. Cancer in Africa: opportunities for collaborative research and training.

    Science.gov (United States)

    Adebamowo, C A; Akarolo-Anthony, S

    2009-06-01

    Cancer is a worldwide public health problem causing increasing morbidity and mortality, particularly in the developing world. Underlying trends are changing the pattern of cancer and this is also being influenced by the HIV/AIDS pandemic, particularly in Sub-Saharan Africa. Even though the pattern of cancer varies across Africa, there are identifiable trends. Breast and cervical cancers, and Kaposi sarcoma are the commonest cancers in women, while Kaposi sarcoma, liver and prostate cancers are the commonest in men. Cancer causes more morbidity and mortality in Africa compared to other parts of the world. Infections account for a disproportionate amount of cancers in Africa. The HIV epidemic is contributing to increased prevalence of many cancers particularly those associated with Herpes and Papilloma viruses. Tobacco use, another major carcinogen, is increasing, particularly among the young. Dietary factors, alcohol use, physical inactivity and environmental pollution are also important aetiological factors of cancer in Africa. In developing countries, poverty, limited government health budget and poor health care systems complicate cancer prevention, treatment and outcomes. Coordinated response by international agencies and NGOs is needed to help developing countries and several successful models exist. More action is also needed on ensuring safety and quality of chemotherapy and the price needs to be reduced. Responses advocated for cancer control in Africa include banning tobacco use, better regulation of alcohol sale, better environmental planning and immunization against cancer associated viruses. Training of health care workers to diagnose cancer and treat it effectively within limited budgets is needed. Research to develop these new treatments and others, particularly from natural products is urgently needed and this can be done safely within established health research ethics regulatory frameworks. Several opportunities for collaborative research and

  11. Statistical study on cancer patients of cancer research hospital

    International Nuclear Information System (INIS)

    The total number of malignant neoplasms included in this study 15,737 cases(11.8%) among 133,251 cases for 3 years. On sex, females with 52.9% were much more than males with 47.1%. The highest proportion of cancer patients by age was 33.7% in males and 28.5% in females, respectivelty for 50-59 age group. The most frequent primary site among males was found to be stomach with 35.5%, followed by liver(14.7%), lung(13.0%), esophagus(5.4%) and colon (3.2%). In females, the first order was uterine cervix with 40.6%, followed by stomach(17.2%), breast(14.4), rectum(3.7%) and lung(3.4%). The most common type of morphology of malignant neoplasms was adenocarcinoma(47.4%) in males an squamous cell carcinoma(58.0%) in females. Among the cancer patients initially diagnosed in this hospital, the proportion of malignant neoplasms by the exent of disease was 2.5% for patient with carcinoma-in-situ, 54.1% for patients with localized involvement, 13.3% for patients with regional involvement and 8.5% for patients with distant involvement. Among the cancer patients initially treatment in this hospital, the proportion of malignant neoplasms by the method of treatment was 23.6% for surgery, 25.3% for radiotherapy and 30.3% for chemotherapy. Among the cancer patients confirmed by medical records, 7.7% was traced more than 5 years. (Author)

  12. A comparison of cancer burden and research spending reveals discrepancies in the distribution of research funding

    Directory of Open Access Journals (Sweden)

    Carter Ashley JR

    2012-07-01

    Full Text Available Abstract Background Ideally, the distribution of research funding for different types of cancer should be equitable with respect to the societal burden each type of cancer imposes. These burdens can be estimated in a variety of ways; “Years of Life Lost” (YLL measures the severity of death in regard to the age it occurs, "Disability-Adjusted Life-Years" (DALY estimates the effects of non-lethal disabilities incurred by disease and economic metrics focus on the losses to tax revenue, productivity or direct medical expenses. We compared research funding from the National Cancer Institute (NCI to a variety of burden metrics for the most common types of cancer to identify mismatches between spending and societal burden. Methods Research funding levels were obtained from the NCI website and information for societal health and economic burdens were collected from government databases and published reports. We calculated the funding levels per unit burden for a wide range of different cancers and burden metrics and compared these values to identify discrepancies. Results Our analysis reveals a considerable mismatch between funding levels and burden. Some cancers are funded at levels far higher than their relative burden suggests (breast cancer, prostate cancer, and leukemia while other cancers appear underfunded (bladder, esophageal, liver, oral, pancreatic, stomach, and uterine cancers. Conclusions These discrepancies indicate that an improved method of health care research funding allocation should be investigated to better match funding levels to societal burden.

  13. Proceedings of thirty second annual convention of Indian Association for Cancer Research: book of abstracts

    International Nuclear Information System (INIS)

    The convention had a broad theme on emerging trends in cancer research, road to prevention and cure and it was an international symposium on infection and cancer. The conference covered vast areas like cancer screening, early detection and prevention, caner genomics and proteonomics, cell cycle regulation and apoptosis, molecular drug designing, cancer immunology and cancer vaccines, molecular epidemiology and clinical cancer research, cancer marker discovery, non-coding RNA regulation, cancer stem cells etc. Papers relevant to INIS are indexed separately

  14. A Review of Barriers to Minorities' Participation in Cancer Clinical Trials: Implications for Future Cancer Research.

    Science.gov (United States)

    Salman, Ali; Nguyen, Claire; Lee, Yi-Hui; Cooksey-James, Tawna

    2016-04-01

    To enhance nurses' awareness and competencies in practice and research by reporting the common barriers to participation of minorities in cancer clinical trials and discussing facilitators and useful strategies for recruitment. Several databases were searched for articles published in peer reviewed journals. Some of the barriers to minorities' participation in clinical trials were identified within the cultural social-context of cancer patients. The involvement of community networking was suggested as the most effective strategy for the recruitment of minorities in cancer clinical trials. Using culturally sensitive approaches to enhance ethnic minorities' participation is important for advancing cancer care and eliminating health disparities. Awareness of barriers and potential facilitators to the enrollment of ethnic minority cancer patients may contribute to enhancing nurses' competencies of recruiting ethnic minorities in nursing research, playing efficient roles in cancer clinical trials team, and providing culturally competent quality care. PMID:25822567

  15. Biomaterials offer cancer research the third dimension.

    Science.gov (United States)

    Hutmacher, Dietmar W

    2010-02-01

    To deepen understanding and hasten the development of treatments, cancer needs to be modelled more accurately in vitro; applying tissue-engineering concepts and approaches in this field could bridge the gap between two-dimensional studies and in vivo animal models. PMID:20094076

  16. Effect on English Output Competence by Exerting Lexical Chunks Ap-proach in Autonomous Learning Model Research

    Institute of Scientific and Technical Information of China (English)

    梅王星; 王艳荣

    2015-01-01

    English language skill is an important part of the comprehensive linguistic competence for college students. Especially the language output competence by students Autonomous Learning. During the 70s of the last century, Becker came up with the term and and later put forward his Lexical Chunks. Since then, it has been researched increasingly and paid more and more atten⁃tion to due to the fact that lexical chunks possess the features of both vocabulary and grammar. Teachers should exert lexical chunks approach, consciously raise students’awareness of lexical chunks, and design various instructional activities based on dif⁃ferent teaching contents to improve students’language output competence. In this paper, the author carries out an experiment on the college students from two classes of the same level in Grade one. And compared with the experimental class itself or with the control class, found the students in experimental class have made far greater progress in English speaking and writing.

  17. 英语学习及教学研究%English Learning and Its Teaching Research

    Institute of Scientific and Technical Information of China (English)

    韩冬玲

    2011-01-01

    The paper analyzes the difficulties students' face while learning English. It also explains the reasons and the ways to solve these problems,emphasizing the English learning skills in listening,speaking,reading and writing.%本文从教学实际角度出发,深刻剖析了学生在学习英语过程中所遇到的困难及原因及其解决方法,重点论述了听、说、读、写四项基本技能在英语学习中的运用技巧。

  18. Brain Cancer in Workers Employed at a Laboratory Research Facility.

    Directory of Open Access Journals (Sweden)

    James J Collins

    Full Text Available An earlier study of research facility workers found more brain cancer deaths than expected, but no workplace exposures were implicated.Adding four additional years of vital-status follow-up, we reassessed the risk of death from brain cancer in the same workforce, including 5,284 workers employed between 1963, when the facility opened, and 2007. We compared the work histories of the brain cancer decedents in relationship to when they died and their ages at death.As in most other studies of laboratory and research workers, we found low rates of total mortality, total cancers, accidents, suicides, and chronic conditions such as heart disease and diabetes. We found no new brain cancer deaths in the four years of additional follow-up. Our best estimate of the brain cancer standardized mortality ratio (SMR was 1.32 (95% confidence interval [95% CI] 0.66-2.37, but the SMR might have been as high as 1.69. Deaths from benign brain tumors and other non-malignant diseases of the nervous system were at or below expected levels.With the addition of four more years of follow-up and in the absence of any new brain cancers, the updated estimate of the risk of brain cancer death is smaller than in the original study. There was no consistent pattern among the work histories of decedents that indicated a common causative exposure.

  19. Research and Reflection in English Studies: The Special Case of Creative Writing

    Science.gov (United States)

    Bizarro, Patrick

    2004-01-01

    A discussion on creative writing's newly improved status in English departments and what its improved status can tell us about disciplinary matters as a whole is presented. There is a need to prepare creative writers not only for their careers as writers, but also for their careers as teachers of creative writing.

  20. Harnessing Storytelling as a Sociopragmatic Skill: Applying Narrative Research to Workplace English Courses

    Science.gov (United States)

    Holmes, Janet; Marra, Meredith

    2011-01-01

    Narratives are often overlooked in workplace talk, but they contribute in crucial ways to relationship building and identity construction in workplace interaction. In this article we analyse narratives told by skilled migrants from non-English-speaking backgrounds during a workplace internship conducted as part of a Workplace Communication course.…

  1. A Qualitative Research on Portfolio Keeping in English as a Foreign Language Writing

    Science.gov (United States)

    Aydin, Selami

    2010-01-01

    Little attention has been paid to the problems about portfolio keeping in English as a foreign language (EFL) writing, while the existing literature mostly focuses on the effects of portfolios on writing skills of learners, rather than those of teachers or pre-service teachers. This study aims to investigate the problems encountered and…

  2. Changes to English as an Additional Language Writers' Research Articles: From Spoken to Written Register

    Science.gov (United States)

    Koyalan, Aylin; Mumford, Simon

    2011-01-01

    The process of writing journal articles is increasingly being seen as a collaborative process, especially where the authors are English as an Additional Language (EAL) academics. This study examines the changes made in terms of register to EAL writers' journal articles by a native-speaker writing centre advisor at a private university in Turkey.…

  3. Assessment and Intervention for English Language Learners with Primary Language Impairment: Research-Based Best Practices

    Science.gov (United States)

    Pieretti, Robert A.; Roseberry-McKibbin, Celeste

    2016-01-01

    Speech-language pathologists (SLPs) are experiencing the exciting challenge of serving increasing numbers of English Language Learners (ELLs) in U.S. schools. When ELLs struggle in school, they may be overreferred for speech-language services. SLPs are routinely expected to differentiate a language difference based on cultural, linguistic, and…

  4. Researching the Effects of Teaching Grammar Rules to English Second Language Adult Learners

    Science.gov (United States)

    Ayliff, D.

    2011-01-01

    This article describes the effects of an interventionist form-focused course on the written English of first-year second language university learners. For two semester courses the form (or grammar) of the language was concentrated upon. During the first semester the use of correct grammar was focussed on intensively, while during the second…

  5. Advancing cancer control research in an emerging news media environment.

    Science.gov (United States)

    Smith, Katherine C; Niederdeppe, Jeff; Blake, Kelly D; Cappella, Joseph N

    2013-12-01

    Cancer is both highly feared and highly newsworthy, and there is a robust body of research documenting the content and effects of cancer news coverage on health behaviors and policy. Recent years have witnessed ongoing, transformative shifts in American journalism alongside rapid advances in communication technology and the public information environment. These changes create a pressing need to consider a new set of research questions, sampling strategies, measurement techniques, and theories of media effects to ensure continued relevance and adaptation of communication research to address critical cancer control concerns. This paper begins by briefly reviewing what we know about the role of cancer news in shaping cancer-related beliefs, attitudes, behaviors, and policies. We then outline challenges and opportunities, both theoretical and methodological, posed by the rapidly changing news media environment and the nature of audience engagement. We organize our discussion around three major shifts associated with the emerging news media environment as it relates to health communication: 1) speed and dynamism of news diffusion, 2) increased narrowcasting of media content for specialized audiences, and 3) broadened participation in shaping media content. In so doing, we articulate a set of questions for future theory and research, in an effort to catalyze innovative communication scholarship to improve cancer prevention and control. PMID:24395988

  6. The transition from university to publication: Register and interactional metadiscourse features in immunology research written in Catalan and English

    Directory of Open Access Journals (Sweden)

    Ana María Pujol Dahme

    2015-11-01

    Full Text Available The ability to use the register and the rhetorical conventions of the research article is important to achieving academic success and professional development in researchers’ careers. Numerous studies have focused on research articles across different disciplines and cross-culturally. However, little research has been carried out into the students’ research report, from a developmental perspective and in a different language from English. To address this gap, we are reporting on a longitudinal study that aimed to characterize the transition of the academic register and the interactional function from university to scientific publication. The research focus is twofold: (1 it examines the academic register by means of lexical diversity, syntactic complexity and lexical density, and (2 it examines and compares the distribution of stance and engagement markers across stages. The data (N = 16 consists of university master’s theses written in Catalan (Romance language and published articles in English, in the discipline of immunology, written by the same eight subjects. As discipline-specific writing conventions are an integral aspect of determining writing proficiency, overall findings suggest that students have not yet acquired writing proficiency, either in academic register or in writer-reader interactions

  7. Lower Breast Cancer Risk among Women following the World Cancer Research Fund and American Institute for Cancer Research Lifestyle Recommendations: EpiGEICAM Case-Control Study

    OpenAIRE

    Adela Castelló; Miguel Martín; Amparo Ruiz; Casas, Ana M.; Baena-Cañada, Jose M; Virginia Lope; Silvia Antolín; Pedro Sánchez; Manuel Ramos; Antonio Antón; Montserrat Muñoz; Begoña Bermejo; Ana De Juan-Ferré; Carlos Jara; José I Chacón

    2015-01-01

    Background According to the “World Cancer Research Fund” and the “American Institute of Cancer Research” (WCRF/AICR) one in four cancer cases could be prevented through a healthy diet, weight control and physical activity. Objective To explore the association between the WCRF/AICR recommendations and risk of breast cancer. Methods During the period 2006 to 2011 we recruited 973 incident cases of breast cancer and 973 controls from 17 Spanish Regions. We constructed a score based on 9 of the W...

  8. Network for Translational Research - Cancer Imaging Program

    Science.gov (United States)

    Cooperative agreement (U54) awards to establish Specialized Research Resource Centers that will participate as members of a network of inter-disciplinary, inter-institutional research teams for the purpose of supporting translational research in optical imaging and/or spectroscopy in vivo, with an emphasis on multiple modalities.

  9. A survey of etiologic hypotheses among testicular cancer researchers

    DEFF Research Database (Denmark)

    Stang, A; Trabert, B; Rusner, C;

    2015-01-01

    Basic research results can provide new ideas and hypotheses to be examined in epidemiological studies. We conducted a survey among testicular cancer researchers on hypotheses concerning the etiology of this malignancy. All researchers on the mailing list of Copenhagen Testis Cancer Workshops and...... plausibility of the suggested etiologic hypotheses on a scale of 1 (very implausible) to 10 (very plausible). This report describes the methodology of the survey, the score distributions by individual hypotheses, hypothesis group, and the participants' major research fields, and discuss the hypotheses that...... etiologic hypotheses that include factors related to endocrine disruption, DNA damage, inflammation, and nutrition during pregnancy. The survey results may stimulate a multidisciplinary discussion about new etiologic hypotheses of testicular cancer....

  10. NIH researchers complete whole-exome sequencing of skin cancer

    Science.gov (United States)

    A team led by researchers at NIH is the first to systematically survey the landscape of the melanoma genome, the DNA code of the deadliest form of skin cancer. The researchers have made surprising new discoveries using whole-exome sequencing, an approach that decodes the 1-2 percent of the genome that contains protein-coding genes.

  11. Implementation of proteomics for cancer research: past, present, and future.

    Science.gov (United States)

    Karimi, Parisa; Shahrokni, Armin; Ranjbar, Mohammad R Nezami

    2014-01-01

    Cancer is the leading cause of the death, accounts for about 13% of all annual deaths worldwide. Many different fields of science are collaborating together studying cancer to improve our knowledge of this lethal disease, and find better solutions for diagnosis and treatment. Proteomics is one of the most recent and rapidly growing areas in molecular biology that helps understanding cancer from an omics data analysis point of view. The human proteome project was officially initiated in 2008. Proteomics enables the scientists to interrogate a variety of biospecimens for their protein contents and measure the concentrations of these proteins. Current necessary equipment and technologies for cancer proteomics are mass spectrometry, protein microarrays, nanotechnology and bioinformatics. In this paper, we provide a brief review on proteomics and its application in cancer research. After a brief introduction including its definition, we summarize the history of major previous work conducted by researchers, followed by an overview on the role of proteomics in cancer studies. We also provide a list of different utilities in cancer proteomics and investigate their advantages and shortcomings from theoretical and practical angles. Finally, we explore some of the main challenges and conclude the paper with future directions in this field. PMID:24761843

  12. Work stress and cancer researchers: an exploration of the challenges, experiences and training needs of UK cancer researchers

    OpenAIRE

    Kennedy, F; Hicks, B.; Yarker, J

    2014-01-01

    Work stress is a significant issue for many UK healthcare professionals, in particular those working in the field of oncology. However, there have been very few attempts to explore the challenges, experiences or training needs of researchers working in cancer research. In doing so, we will be better positioned to support and develop these researchers. 18 UK oncology researchers from a variety of backgrounds took part in a semi-structured interview. Interviews were transcribed and analysed...

  13. Dr. Marco Marra: Pioneer and Visionary in Cancer Genomics Research | Office of Cancer Genomics

    Science.gov (United States)

    Dr. Marco Marra is a highly distinguished genomics and bioinformatics researcher. He is the Director of Canada’s Michael Smith Genome Sciences Centre at the BC Cancer Agency and holds a faculty position at the University of British Columbia. The Centre is a state-of-the-art sequencing facility in Vancouver, Canada, with a major focus on the study of cancers.  Many of their research projects are undertaken in collaborations with other Canadian and international institutions.

  14. Perineural Invasion in Pancreatic Cancer: Advanced Research in the Neuro-cancer Interactions

    Directory of Open Access Journals (Sweden)

    Xiao-hong SHEN

    2010-12-01

    Full Text Available Pancreatic Cancer (PCa is characterized by prominently local nerve alterations and perineural invasion (PNI, which frequently affects the extrapancreatic nerve plexus, causing severe pain and retropancreatic tumor extension. It precludes curative resection, promotes local recurrence, and at the last negatively influences the prognosis of patients. Recent research on PNI in PCa has revealed the critical involvement of numerous nerve- or cancer cell-derived molecules in vitro and in vivo. However, the mechanisms contributing to alteration and invasion of intrapancreatic nerves and the spread of cancer cells along extrapancreatic nerves in pancreatic cancer patients are still poorly understood. This review focuses on perineural invasion in pancreatic cancer and provides an outline of the characteristics and molecular mechanisms of perineural invasion in pancreatic cancer.

  15. English Proficiency and English Exposure in the Media. A comparative study between countries with high and low English exposure

    OpenAIRE

    Molnár, Máté, 1989-

    2013-01-01

    The aim of this essay is to demonstrate the differences between countries that are exposed to English, and countries that are not exposed to English in the media. The English exposure in the media of Iceland and Hungary are presented as examples of countries with a different amount of English exposure. The research on the English exposure of these two countries illustrates that Icelanders are more exposed to English than Hungarians and that Icelanders are more proficient in English. A study w...

  16. Institutional shared resources and translational cancer research

    OpenAIRE

    De Paoli Paolo

    2009-01-01

    Abstract The development and maintenance of adequate shared infrastructures is considered a major goal for academic centers promoting translational research programs. Among infrastructures favoring translational research, centralized facilities characterized by shared, multidisciplinary use of expensive laboratory instrumentation, or by complex computer hardware and software and/or by high professional skills are necessary to maintain or improve institutional scientific competitiveness. The s...

  17. The Research of English Teachers’ Confusion and Professional Development Direction Under the New Situation

    Institute of Scientific and Technical Information of China (English)

    Liu; Haiying

    2015-01-01

    At present,because of the confusion of various factors such as enrollment expansion of colleges,the increasing graduates and so on,the teachers of higher colleges will not only finish the burdensome teaching task,but also finish their own promotion and development gradually to develop students’ practical abilities and value cultural education and personality.English teachers should pay more attention to their professional development.

  18. The Research of English Teachers' Confusion and Professional Development Direction Under the New Situation

    Institute of Scientific and Technical Information of China (English)

    Liu Haiying

    2015-01-01

    At present,because of the confusion of various factors such as enrollment expansion of colleges,the increasing graduates and so on,the teachers of higher colleges will not only finish the burdensome teaching task,but also finish their own promotion and development gradually to develop students’ practical abilities and value cultural education and personality. English teachers should pay more attention to their professional development.

  19. College English Students’Autonomous Learning Motivation and Cultivation Model Research

    Institute of Scientific and Technical Information of China (English)

    王艳荣; 李娥

    2015-01-01

    Studying the autonomous learning motivation and excitation model can stimulate intrinsic motivation of foreign language learners,develop students self-management strategy evaluation are very necessary.The purpose of this paper is to give students the skills of listening and speaking for their autonomous learning.Then study the cultivation and motivation of college English students autonomous learning,hoping to make students to learn autonomous learning and stimulate their motivation fully.

  20. Research on Chinese College English Teachers’ Classroom Code-switching: Beliefs and Attitudes

    OpenAIRE

    Xiaoli Cheng

    2013-01-01

    This article documents the beliefs and attitudes of Chinese college English teachers towards classroom code-switching. The findings suggest that teachers’ code-switching is commonplace in class, although most of them still hold negative attitude toward it. Besides, students’ ability is regarded as the most significant factor affecting teachers’ code-switching, and the first language (L1) is mainly used to teach grammar and abstract words. The conclusion is that, in Chinese E...

  1. A Research of Task-based Language Teaching Applied to the College Oral English Teaching

    Institute of Scientific and Technical Information of China (English)

    王景琦; 祝菁

    2016-01-01

    Task-based Language Teaching has been greatly applied to college English teaching after the traditional “PPP”teaching approach. The key links in TBLT are assignment, development and inspection of tasks. With the main method, interactive communication,“students-centered ” is stressed, and students' subjective dynamics is fully exerted. Class time can be effectively used and students' communicative ability is cultivated with the improvement of oral expression ability.

  2. A research in sustainable competitive positional advantage of english dailies in Tamilnadu (India)

    OpenAIRE

    Selvarasu, A.; Filipe, J. A.; C. Kathiravan; Manuel Alberto M. Ferreira; Pedro, M. I.

    2011-01-01

    The aim of this study is to identify and to describe the sustainable competitive positional advantage of various English Dailies in Tamilnadu (India) in general. Cost leaderships (price) and the differentiations based on demographics, psychographics, reading activity, opinion and interest are particularly considered. In order to reach this scope a theory of sustainable competitive positional advantage is proposed, in the context of print media in India.

  3. The Aurora kinase inhibitors in cancer research and therapy.

    Science.gov (United States)

    Cicenas, Jonas

    2016-09-01

    Compounds that affect enzymatic function of kinases are valuable for the understanding of the complex biochemical processes in cells. Aurora kinases (AURKs) play a key role in the control of the mitosis. These kinases are frequently deregulated in different human cancers: overexpression, amplifications, translocations and deletions were reported in many cancer cell lines as well as patient tissues. These findings steered a rigorous hunt for small-molecule AURK inhibitors not only for research purposes as well as for therapeutic uses. In this review, we describe a number of AURK inhibitors and their use in cancer research and/or therapy. We hope to assist researchers and clinicians in deciding which inhibitor is most appropriate for their specific purpose. The review will also provide a broad overview of the clinical studies performed with some of these inhibitors (if such studies have been performed). PMID:26932147

  4. Economic terms and beyond how researchers in specialised varieties of English can benefit from focusing on terms

    CERN Document Server

    Resche, Catherine

    2013-01-01

    This book, which is aimed at researchers in specialised varieties of English, provides an illustration of how linguists can use terms, i.e. the expression of concepts in specialised fields, as entry points to explore any specialised domain, whether academic or professional, and to get acquainted with its history, its culture, and the evolution of the ideas that have nurtured it. Choosing the field of economics as an example, the author approaches terms from a diachronic, descriptive and contextual perspective, focusing on neonyms, metaphorical, ambiguous or indeterminate terms, as well as inte

  5. Public figure announcements about cancer and opportunities for cancer communication: a review and research agenda.

    Science.gov (United States)

    Noar, Seth M; Willoughby, Jessica Fitts; Myrick, Jessica Gall; Brown, Jennifer

    2014-01-01

    Announcements by public figures and celebrities about cancer diagnosis or death represent significant events in public life. But what are the substantive effects of such events, if any? The purpose of this article is to systematically review studies that examined the impact of public figure cancer announcements on cancer-oriented outcomes. Using comprehensive search procedures, we identified k = 19 studies that examined 11 distinct public figures. The most commonly studied public figures were Jade Goody, Kylie Minogue, Nancy Reagan, and Steve Jobs, with the most common cancers studied being breast (53%), cervical (21%), and pancreatic (21%) cancer. Most studies assessed multiple outcome variables, including behavioral outcomes (k = 15), media coverage (k = 10), information seeking (k = 8), cancer incidence (k = 3), and interpersonal communication (k = 2). Results fairly consistently indicated that cancer announcements from public figures had meaningful effects on many, if not most, of these outcome variables. While such events essentially act as naturally occurring interventions, the effects tend to be relatively short term. Gaps in this literature include few contemporary studies of high-profile public figures in the United States and a general lack of theory-based research. Directions for future research as well as implications for cancer communication and prevention are discussed. PMID:23845155

  6. A review of cervical cancer research in malaysia.

    Science.gov (United States)

    Zaridah, S

    2014-08-01

    Despite cervical cancer being potentially preventable, it is the second most common cancer among women in Malaysia. One hundred and five articles related to Cervical Cancer were found in a search through a database dedicated to indexing all original data relevant to medicine published in Malaysia between the years 2000-2013. Fifty seven articles were selected and reviewed for the articles' clinical relevance and future research implications. This article reviews the various aspects of cervical cancer in Malaysia, mainly persistent infection of high risk human papillomavirus (HPV), primary prevention (HPV vaccination), screening method (Pap smear issues), and the attitude and knowledge of various groups of Malaysian women that contributed to the failure to reduce the incidence and mortality of cervical cancer. Most of the studies focused on prevention, Pap smear issues, HPV DNA testing, HPV vaccination and various recommendations for prevention of cervical cancer. Secondary prevention by screening is still an important aspect because even with HPV vaccination, screening still plays an important role as vaccination does not cover all high risk HPVs. There is a need to seriously consider a properly organised screening programme, taking into consideration what we already know about the attitude and knowledge of Malaysian women, economic factors and psychosocial issues of the screening method. There is also a large gap in clinical studies on the outcome, management and survival of cervical cancer patients in Malaysia. PMID:25417949

  7. Application of Metabolomics in Drug Resistant Breast Cancer Research

    Directory of Open Access Journals (Sweden)

    Ayesha N. Shajahan-Haq

    2015-02-01

    Full Text Available The metabolic profiles of breast cancer cells are different from normal mammary epithelial cells. Breast cancer cells that gain resistance to therapeutic interventions can reprogram their endogenous metabolism in order to adapt and proliferate despite high oxidative stress and hypoxic conditions. Drug resistance in breast cancer, regardless of subgroups, is a major clinical setback. Although recent advances in genomics and proteomics research has given us a glimpse into the heterogeneity that exists even within subgroups, the ability to precisely predict a tumor’s response to therapy remains elusive. Metabolomics as a quantitative, high through put technology offers promise towards devising new strategies to establish predictive, diagnostic and prognostic markers of breast cancer. Along with other “omics” technologies that include genomics, transcriptomics, and proteomics, metabolomics fits into the puzzle of a comprehensive systems biology approach to understand drug resistance in breast cancer. In this review, we highlight the challenges facing successful therapeutic treatment of breast cancer and the innovative approaches that metabolomics offers to better understand drug resistance in cancer.

  8. Advanced Research on Circulating Tumor Cells in Lung Cancer

    Directory of Open Access Journals (Sweden)

    Hui LI

    2012-11-01

    Full Text Available Lung cancer is the malignant disease with the highest rate in terms of incidence and mortality in China. Early diagnosis and timely monitoring tumor recurrence and metastasis are extremely important for improving 5-year survival rate of lung cancer patients. Circulating tumor cells (CTCs, as a "liquid biopsy specimens” for the primary tumor, provide the possibility to perform real-time, non-invasive histological identification for lung cancer patients. The detection of CTCs contributes to early diagnosis, surveillance of tumor recurrence and metastasis, and prediction of therapeutic efficacy and prognosis. Furthermore, CTCs-dependent detection emerges as a new approach for molecularly pathologic examination, study of molecular mechanisms involved in drug resistance, and resolution for tumor heterogeneity. This study reviewed the recent progress of CTCs in lung cancer research field.

  9. Why do some countries publish more than others? An international comparison of research funding, English proficiency and publication output in highly ranked general medical journals.

    Science.gov (United States)

    Man, Jonathan P; Weinkauf, Justin G; Tsang, Monica; Sin, Don D

    2004-01-01

    National factor(s) influencing publication output in the highest ranked medical journals are largely unknown. We sought to examine the relationship between national research funding and English proficiency on publication output. We identified all original research articles appearing in the five highest ranked general medical journals between 1997 and 2001. Using the country of the corresponding author as the source nation for each article, we determined a standardized publication rate across developed nations. We used multiple regression techniques to determine the influence of national expenditures on research and scores from the Test of English as a Foreign Language (TOEFL), a surrogate for English proficiency, on publication output. There was a significant relationship of national spending on research and TOEFL scores to publication output of developed countries (p = 0.04; p < 0.01, respectively). These two variables explained approximately 71.5% of the variation in publication rate across developed nations around the world (R = 0.85; p < 0.01). Normalized for population size, English-speaking nations and certain northern European countries such as Denmark, The Netherlands, Switzerland, and Sweden had the highest rate of publication in the five highest ranked general medical journals, while Asian countries had generally low rates of publication. Research spending and English proficiency were strongly associated with publication output in the highest ranked general medical journals. While these data cannot be considered definitive due to their observational nature, they do suggest that for English-language medical journals, research funding and English proficiency may be important determinants of publication. PMID:15469039

  10. What's New in Nasal Cavity and Paranasal Sinus Cancer Research and Treatment?

    Science.gov (United States)

    ... What’s new in nasal cavity and paranasal sinus cancer research and treatment? There is always research going on ... ways to prevent nasal cavity and paranasal sinus cancers. Research on better treatment for nasal cavity and paranasal ...

  11. Accelerating cancer systems biology research through Semantic Web technology.

    Science.gov (United States)

    Wang, Zhihui; Sagotsky, Jonathan; Taylor, Thomas; Shironoshita, Patrick; Deisboeck, Thomas S

    2013-01-01

    Cancer systems biology is an interdisciplinary, rapidly expanding research field in which collaborations are a critical means to advance the field. Yet the prevalent database technologies often isolate data rather than making it easily accessible. The Semantic Web has the potential to help facilitate web-based collaborative cancer research by presenting data in a manner that is self-descriptive, human and machine readable, and easily sharable. We have created a semantically linked online Digital Model Repository (DMR) for storing, managing, executing, annotating, and sharing computational cancer models. Within the DMR, distributed, multidisciplinary, and inter-organizational teams can collaborate on projects, without forfeiting intellectual property. This is achieved by the introduction of a new stakeholder to the collaboration workflow, the institutional licensing officer, part of the Technology Transfer Office. Furthermore, the DMR has achieved silver level compatibility with the National Cancer Institute's caBIG, so users can interact with the DMR not only through a web browser but also through a semantically annotated and secure web service. We also discuss the technology behind the DMR leveraging the Semantic Web, ontologies, and grid computing to provide secure inter-institutional collaboration on cancer modeling projects, online grid-based execution of shared models, and the collaboration workflow protecting researchers' intellectual property. PMID:23188758

  12. Radiation and lung cancer: problems and topics of future research

    International Nuclear Information System (INIS)

    It was the purpose of this critical review to outline the main uncertainties of present risk estimates for radiation-induced lung cancer and the resulting topics of future research in this field. The main emphasis was the actual problems of dose and risk estimates for indoor exposure to radon daughters. The discussion indicates that the conclusions of the ICRP and the BEIR IV studies, which proceed from data of radon-exposed miners, are based on models and assumptions that are too simple. Comparison with the lung cancer data from the atomic bomb survivors indicates that these uncertainties concern mainly the transfer of the data from male miners to the female population and the influence of smoking. This underlines the importance of large direct case-control studies on lung cancer from indoor radon. A detailed list of topics for future research in this field is presented in the summary of this session. (author)

  13. Interactional Markers in English Medical Research Articles Written by Iranian and Native Authors: A Contrastive Metadiscourse Analysis of Method Section

    Directory of Open Access Journals (Sweden)

    Fariba Ghadyani

    2014-08-01

    Full Text Available To determine the issue of whether there were any significant differences between the groups including Iran ISI, Iran non- ISI, and native authors in binary comparisons as for employing interactional markers, the present study was conducted. To collect the data, 90 'method sections' of  English medical research articles within Iranian ISI, Iranian non- ISI, and native ISI journals written by Iranian and native authors published between 2005 and 2010, were examined. As the model of analysis, Hyland's (2005 taxonomy of metadiscourse markers was used. After performing quantitative and qualitative analyses of the interactional markers, Chi- Square tests were run. The results of the study at p= 0.05 revealed significant differences in binary comparisons made up of native / Iran ISI, native / Iran non- ISI, and Iran ISI/ Iran non-ISI as for employing self-mentions. The findings also demonstrated a significant difference between Native and Iran ISI groups for using boosters. These differences may be influenced by the writers' mother tongue, culture and also by their lack or limited awareness of the rhetorical conventions of English medical academic research writing which are needed to be taken into consideration. 

  14. Applications of slow positrons to cancer research: Search for selectivity of positron annihilation to skin cancer

    Energy Technology Data Exchange (ETDEWEB)

    Jean, Y.C. [Department of Chemistry, University of Missouri-Kansas City, 205 Spenscer Chemistry Building, 5009 Rockhill Road, Kansas City, MO 64110 (United States)]. E-mail: jeany@umkc.edu; Li Ying [Department of Chemistry, University of Missouri-Kansas City, 205 Spenscer Chemistry Building, 5009 Rockhill Road, Kansas City, MO 64110 (United States); Liu Gaung [Department of Chemistry, University of Missouri-Kansas City, 205 Spenscer Chemistry Building, 5009 Rockhill Road, Kansas City, MO 64110 (United States); Chen, Hongmin [Department of Chemistry, University of Missouri-Kansas City, 205 Spenscer Chemistry Building, 5009 Rockhill Road, Kansas City, MO 64110 (United States); Zhang Junjie [Department of Chemistry, University of Missouri-Kansas City, 205 Spenscer Chemistry Building, 5009 Rockhill Road, Kansas City, MO 64110 (United States); Gadzia, Joseph E. [Dermatology, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS 66103 (United States); Kansas Medical Clinic, Topeka, KS 66614 (United States)

    2006-02-28

    Slow positrons and positron annihilation spectroscopy (PAS) have been applied to medical research in searching for positron annihilation selectivity to cancer cells. We report the results of positron lifetime and Doppler broadening energy spectroscopies in human skin samples with and without cancer as a function of positron incident energy (up to 8 {mu}m depth) and found that the positronium annihilates at a significantly lower rate and forms at a lower probability in the samples having either basal cell carcinoma (BCC) or squamous cell carcinoma (SCC) than in the normal skin. The significant selectivity of positron annihilation to skin cancer may open a new research area of developing positron annihilation spectroscopy as a novel medical tool to detect cancer formation externally and non-invasively at the early stages.

  15. Mapping cancer, cardiovascular and malaria research in Brazil

    Directory of Open Access Journals (Sweden)

    P.S. Rodrigues

    2000-08-01

    Full Text Available This paper presents performance indicators for the Brazilian cancer, cardiovascular and malaria research areas from 1981 to 1995. The data show an increasing number of papers since 1981 and author numbers indicate a continuous growth of the scientific community and suggest an expected impact of scientific activity on biomedical education. The data also characterize cardiovascular research as a well-established area and cancer research as a faster growing consolidating field. The 1989-1994 share of Brazilian articles among world publications shows a growing trend for the cancer (1.61 and cardiovascular (1.59 areas, and a decrease for the malaria area (0.89. The burden of the three diseases on society is contrasted by the small number of consolidated Brazilian research groups, and a questionable balance of thematic activity, especially with regard to malaria. Brazilian periodicals play an important role in increasing the international visibility of science produced in the country. Cancer and cardiovascular research is strongly concentrated in the Southeastern and in Southern regions of Brazil, especially in São Paulo (at least one address from São Paulo in 64.5% of the 962 cancer articles and in 66.9% of the 2250 cardiovascular articles, the second state being Rio de Janeiro with at least one address in 14.1 and 11% of those articles, respectively. Malaria research (468 articles is more evenly distributed across the country, following the pattern of the endemic distribution of the disease. Surveying these national indicator trends can be useful to establish policies in the decision process about health sciences, medical education and public health.

  16. Integrating Heterogeneous Biomedical Data for Cancer Research: the CARPEM infrastructure.

    Science.gov (United States)

    Rance, Bastien; Canuel, Vincent; Countouris, Hector; Laurent-Puig, Pierre; Burgun, Anita

    2016-01-01

    Cancer research involves numerous disciplines. The multiplicity of data sources and their heterogeneous nature render the integration and the exploration of the data more and more complex. Translational research platforms are a promising way to assist scientists in these tasks. In this article, we identify a set of scientific and technical principles needed to build a translational research platform compatible with ethical requirements, data protection and data-integration problems. We describe the solution adopted by the CARPEM cancer research program to design and deploy a platform able to integrate retrospective, prospective, and day-to-day care data. We designed a three-layer architecture composed of a data collection layer, a data integration layer and a data access layer. We leverage a set of open-source resources including i2b2 and tranSMART. PMID:27437039

  17. Integrating Heterogeneous Biomedical Data for Cancer Research: the CARPEM infrastructure

    Science.gov (United States)

    Canuel, Vincent; Countouris, Hector; Laurent-Puig, Pierre; Burgun, Anita

    2016-01-01

    Summary Cancer research involves numerous disciplines. The multiplicity of data sources and their heterogeneous nature render the integration and the exploration of the data more and more complex. Translational research platforms are a promising way to assist scientists in these tasks. In this article, we identify a set of scientific and technical principles needed to build a translational research platform compatible with ethical requirements, data protection and data-integration problems. We describe the solution adopted by the CARPEM cancer research program to design and deploy a platform able to integrate retrospective, prospective, and day-to-day care data. We designed a three-layer architecture composed of a data collection layer, a data integration layer and a data access layer. We leverage a set of open-source resources including i2b2 and tranSMART. PMID:27437039

  18. Alliance Against Cancer, the network of Italian cancer centers bridging research and care.

    Science.gov (United States)

    De Paoli, Paolo; Ciliberto, Gennaro; Ferrarini, Manlio; Pelicci, PierGiuseppe; Dellabona, Paolo; De Lorenzo, Francesco; Mantovani, Alberto; Musto, Pellegrino; Opocher, Giuseppe; Picci, Piero; Ricciardi, Walter; De Maria, Ruggero

    2015-01-01

    Alliance Against Cancer (ACC) was established in Rome in 2002 as a consortium of six Italian comprehensive cancer centers (Founders). The aims of ACC were to promote a network among Italian oncologic institutions in order to develop specific, advanced projects in clinical and translational research. During the following years, many additional full and associate members joined ACC, that presently includes the National Institute of Health, 17 research-oriented hospitals, scientific and patient organizations. Furthermore, in the last three years ACC underwent a reorganization process that redesigned the structure, governance and major activities. The present goal of ACC is to achieve high standards of care across Italy, to implement and harmonize principles of modern personalized and precision medicine, by developing cost effective processes and to provide tailored information to cancer patients. We herein summarize some of the major initiatives that ACC is currently developing to reach its goal, including tumor genetic screening programs, establishment of clinical trial programs for cancer patients treated in Italian cancer centers, facilitate their access to innovative drugs under development, improve quality through an European accreditation process (European Organization of Cancer Institutes), and develop international partnerships. In conclusion, ACC is a growing organization, trying to respond to the need of networking in Italy and may contribute significantly to improve the way we face cancer in Europe. PMID:26578263

  19. Collaboration - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    Despite great strides in proteomics and the growing number of articles citing the discovery of potential biomarkers, the actual rate of introduction of Food and Drug Administration (FDA) approved protein analytes has been relatively unchanged over the past 10 years. One of reasons for the lack of new protein-based biomarkers approved has been a lack of information and understanding by the proteomics research community to the regulatory process used by the FDA.

  20. Model-driven architecture for cancer research

    OpenAIRE

    Calinescu, R.; Harris, S.; Gibbons, J.; Toujilov, I.; Nagl, S

    2007-01-01

    Abstract It is a common phenomenon for research projects to collect and analyse valuable data using ad-hoc information systems. These costly-to-build systems are often composed of incompatible variants of the same modules, and record data in ways that prevent any meaningful result analysis across similar projects. We present a framework that uses a combination of formal methods, model-driven development and service-oriented architecture (SOA) technologies to automate the generation of data ma...

  1. Educating cancer prevention researchers in emerging biobehavioral models: lessons learned.

    Science.gov (United States)

    Correa-Fernández, Virmarie; Davila, Marivel; Kamrudin, Samira A; Li, Dennis H; Noor, Syed W; Oluyomi, Abiodun O; Chang, Shine; Cameron, Carrie

    2011-12-01

    To increase the adoption of transdisciplinary research methods among future cancer prevention investigators, faculty members from The University of Texas MD Anderson Cancer Center developed a graduate-level course in biobehavioral methods in cancer prevention research. Two instructors paired by topic and area of expertise offered an hour-long lecture-based seminar every week for 15 weeks during the spring semester of 2010. Students and presenters both evaluated the overall course content and delivery method, as well as each session. A total of 11 students and 22 presenters participated in the course. In each class session, one presenter was from a behavioral science background,and the other was from a biological sciences background. Both presenters and students expressed overall satisfaction with the content and format of the course. The presentation of topics from a transdisciplinary perspective and interaction with presenters from both biological and behavioral sciences are valuable and can help junior researchers prepare to meet the emerging challenges in cancer prevention research. PMID:21720937

  2. Tumor Cold Ischemia - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    In a recently published manuscript in the journal of Molecular and Cellular Proteomics, researchers from the National Cancer Institutes (NCI) Clinical Proteomic Tumor Analysis Consortium (CPTAC) investigated the effect of cold ischemia on the proteome of fresh frozen tumors.

  3. About the Nutritional Science Research Group | Division of Cancer Prevention

    Science.gov (United States)

    The Nutritional Science Research Group (NSRG) promotes and supports studies establishing a comprehensive understanding of the precise role of diet and food components in modulating cancer risk and tumor cell behavior. This focus includes approaches to characterize molecular targets and variability in individual responses to nutrients and dietary patterns. |

  4. Donation Intentions for Cancer Genetics Research Among African Americans

    OpenAIRE

    McDonald, Jasmine A; Weathers, Benita; Barg, Frances K.; Troxel, Andrea B; Shea, Judy A; Bowen, Deborah; Guerra, Carmen E.; Halbert, Chanita Hughes

    2012-01-01

    Aims: Scientific agencies rely on individuals to donate their DNA to support research on chronic conditions that disproportionately affect African Americans; however, donation is variable in this population. The purpose of this study was to identify sociodemographic characteristics, health care variables, and cultural values having significant independent associations with intentions to donate blood or saliva samples for cancer genetics research among African American adults. Method: Cross-se...

  5. Research Priorities, Measures, and Recommendations for Assessment of Tobacco Use in Clinical Cancer Research.

    Science.gov (United States)

    Land, Stephanie R; Toll, Benjamin A; Moinpour, Carol M; Mitchell, Sandra A; Ostroff, Jamie S; Hatsukami, Dorothy K; Duffy, Sonia A; Gritz, Ellen R; Rigotti, Nancy A; Brandon, Thomas H; Prindiville, Sheila A; Sarna, Linda P; Schnoll, Robert A; Herbst, Roy S; Cinciripini, Paul M; Leischow, Scott J; Dresler, Carolyn M; Fiore, Michael C; Warren, Graham W

    2016-04-15

    There is strong evidence that cigarette smoking causes adverse outcomes in people with cancer. However, more research is needed regarding those effects and the effects of alternative tobacco products and of secondhand smoke, the effects of cessation (before diagnosis, during treatment, or during survivorship), the biologic mechanisms, and optimal strategies for tobacco dependence treatment in oncology. Fundamentally, tobacco is an important source of variation in clinical treatment trials. Nevertheless, tobacco use assessment has not been uniform in clinical trials. Progress has been impeded by a lack of consensus regarding tobacco use assessment suitable for cancer patients. The NCI-AACR Cancer Patient Tobacco Use Assessment Task Force identified priority research areas and developed recommendations for assessment items and timing of assessment in cancer research. A cognitive interview study was conducted with 30 cancer patients at the NIH Clinical Center to evaluate and improve the measurement items. The resulting Cancer Patient Tobacco Use Questionnaire (C-TUQ) includes "Core" items for minimal assessment of tobacco use at initial and follow-up time points, and an "Extension" set. Domains include the following: cigarette and other tobacco use status, intensity, and past use; use relative to cancer diagnosis and treatment; cessation approaches and history; and secondhand smoke exposure. The Task Force recommends that assessment occur at study entry and, at a minimum, at the end of protocol therapy in clinical trials. Broad adoption of the recommended measures and timing protocol, and pursuit of the recommended research priorities, will help us to achieve a clearer understanding of the significance of tobacco use and cessation for cancer patients.Clin Cancer Res; 22(8); 1907-13. ©2016 AACR. PMID:26888828

  6. Does science need a global language? English and the future of research

    CERN Document Server

    Montgomery, Scott L

    2013-01-01

    In early 2012, the global scientific community erupted with news that the elusive Higgs boson had likely been found, providing potent validation for the Standard Model of how the universe works. Scientists from more than one hundred countries contributed to this discovery-proving, beyond any doubt, that a new era in science had arrived, an era of multinationalism and cooperative reach. Globalization, the Internet, and digital technology all play a role in making this new era possible, but something more fundamental is also at work. In all scientific endeavors lies the ancient drive for sharing ideas and knowledge, and now this can be accomplished in a single tongue - English. But is this a good thing? In "Does Science Need a Global Language?", Scott L. Montgomery seeks to answer this question by investigating the phenomenon of global English in science, how and why it came about, the forms in which it appears, what advantages and disadvantages it brings, and what its future might be. He also examines the cons...

  7. Targeting hedgehog signaling in cancer: research and clinical developments

    Directory of Open Access Journals (Sweden)

    Xie J

    2013-10-01

    Full Text Available Jingwu Xie, Christopher M Bartels, Scott W Barton, Dongsheng GuWells Center for Pediatric Research, Division of Hematology and Oncology, Department of Pediatrics, Indiana University Simon Cancer Center, Indiana University, Indianapolis, IN, USAAbstract: Since its first description in Drosophila by Drs Nusslein-Volhard and Wieschaus in 1980, hedgehog (Hh signaling has been implicated in regulation of cell differentiation, proliferation, tissue polarity, stem cell maintenance, and carcinogenesis. The first link of Hh signaling to cancer was established through studies of Gorlin syndrome in 1996 by two independent teams. Later, it was shown that Hh signaling may be involved in many types of cancer, including skin, leukemia, lung, brain, and gastrointestinal cancers. In early 2012, the US Food and Drug Administration approved the clinical use of Hh inhibitor Erivedge/vismodegib for treatment of locally advanced and metastatic basal cell carcinomas. With further investigation, it is possible to see more clinical applications of Hh signaling inhibitors. In this review, we will summarize major advances in the last 3 years in our understanding of Hh signaling activation in human cancer, and recent developments in preclinical and clinical studies using Hh signaling inhibitors.Keywords: hedgehog, smoothened, PTCH1, cancer, signal transduction, clinical trials, animal model

  8. Cooperative research and development opportunities with the National Cancer Institute

    Science.gov (United States)

    Sybert, Kathleen

    1991-01-01

    The Office of Technology Development (OTD) of the National Cancer Institute (NCI) is responsible for negotiating Cooperative Research and Development Agreements (CRADAs), whereby the knowledge resulting from NCI investigators' government-sponsored research is developed in collaboration with universities and/or industry into new products of importance for the diagnosis and treatment of cancer and acquired immunodeficiency syndrome (AIDS). The NCI has recently executed a unique 'clinical trials' CRADA and is developing a model agreement based upon it for the development and commercialization of products for the diagnosis and treatment of cancer and AIDS. NCI drug screening, preclinical testing, clinical trials, and AIDS program capabilities form the basis for this new technology development/technology transfer vehicle. NCI's extensive drug screening program and 'designer foods' program serve as potential sources of investigational new drugs (INDs) and cancer preventatives. Collaborations between NCI and pharmaceutical companies having the facilities, experience, and expertise necessary to develop INDs into approved drugs available to the public are being encouraged where the companies have proprietary rights to INDs, or where NCI has proprietary rights to INDs and invites companies to respond to a collaborator announcement published in the Federal Register. The joint efforts of the NCI and the chosen collaborator are designed to generate the data necessary to obtain pharmaceutic regulatory approval from the Food and Drug Administration (FDA) to market the drugs developed, and thereby make them available to health care providers for the diagnosis and treatment of cancer and AIDS.

  9. A Good Foundation for Number Learning for Five-Year-Olds? An Evaluation of the English Early Learning "Numbers" Goal in the Light of Research

    Science.gov (United States)

    Gifford, Sue

    2014-01-01

    This article sets out to evaluate the English Early Years Foundation Stage Goal for Numbers, in relation to research evidence. The Goal, which sets out to provide "a good foundation in mathematics", has greater breadth of content and higher levels of difficulty than previous versions. Research suggests that the additional expectations…

  10. Piloting the Post-Entry Language Assessment: Outcomes from a New System for Supporting Research Candidates with English as an Additional Language

    Science.gov (United States)

    Tynan, Liz; Johns, Kellie

    2015-01-01

    The Post-Entry Language Assessment (PELA) was introduced by the James Cook University Graduate Research School in February 2013 as a pilot programme to test a new mechanism for initiating post-enrolment support for research degree candidates who have English as an additional language. Language ability does not necessarily, on its own, predict…

  11. Systems biology in the frontier of cancer research: a report of the Second International Workshop of Cancer Systems Biology

    OpenAIRE

    Ying Xu; Yan-Chun Liang; Juan Cui

    2012-01-01

    The report summarizes the Second International Workshop of Cancer Systems Biology held on July 5-6, 2012 in Changchun, China. The goal of the workshop was to bring together cancer researchers with different backgrounds to share their views about cancer and their experiences in fighting against cancer, and to gain new and systems-level understanding about cancer formation, progression, diagnosis, and treatment through exchanging ideas.

  12. Systems biology in the frontier of cancer research:a report of the Second International Workshop of Cancer Systems Biology

    Institute of Scientific and Technical Information of China (English)

    Juan Cui; Yan-Chun Liang; Ying Xu

    2012-01-01

    The report summarizes the Second International Workshop of Cancer Systems Biology held on July 5-6,2012 in Changchun,China.The goal of the workshop was to bring together cancer researchers with different backgrounds to share their views about cancer and their experiences in fighting against cancer,and to gain new and systems-level understanding about cancer formation,progression,diagnosis,and treatment through exchanging ideas.

  13. CPTAC Scientific Symposium - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    On behalf of the National Cancer Institute and the Office of Cancer Clinical Proteomics Research, you are invited to the First Annual CPTAC Scientific Symposium on Wednesday, November 13, 2013. The purpose of this symposium, which consists of plenary and poster sessions, is for investigators from CPTAC community and beyond to share and discuss novel biological discoveries, analytical methods, and translational approaches using CPTAC data. All scientists who use, or wish to use CPTAC data are welcome to participate at this free event. The symposium will be held at the Natcher Conference Facility on the main campus of the National Institutes of Health in Bethesda, Maryland.

  14. Intermediate markers as surrogate endpoints in cancer research.

    Science.gov (United States)

    Schatzkin, A

    2000-08-01

    Because studies with surrogate cancer endpoints can be smaller, faster, and substantially less expensive than those with frank cancer outcomes, the use of surrogate endpoints is undeniably attractive. This attractiveness is likely to grow in coming years as the rapidly advancing discoveries in cell and molecular biology generate new therapies requiring testing and new markers that could plausibly serve as surrogates for cancer. Surrogate endpoint studies can certainly be suggestive. They continue to play a legitimate role in phase II studies, and they may give the right answers about intervention effects on or exposure associations with cancer. The problem is the uncertainty attached to most potential surrogates. Except for those few surrogates that are both necessary for and developmentally relatively close to cancer, the existence of plausible alternative pathways makes inferences about cancer from many surrogates problematic. Merely being on the causal pathway to cancer does not in itself constitute surrogate validity. It is the totality of causal connections that is critical. There is, unfortunately, a fairly extensive history of quite plausible surrogate markers giving the wrong answer about various chronic disease therapies. There is no reason to believe that cancer surrogacy is immune to such inferential difficulties. This article is, in part, an invitation, even a plea, for researchers to carry out the investigations necessary to evaluate potential surrogates, particularly surrogate-cancer studies and intervention or exposure-surrogate-cancer mediation analyses. Such studies are needed to generalize from surrogate endpoint findings to cancer. There is, however, an implicit and perhaps unavoidable irony here: the large, long, expensive studies required to evaluate potential surrogates fully are precisely the studies that surrogates were designed to replace. The exposure dependence alluded to earlier complicates matters further: establishing validity for a

  15. Research on Situational Teaching of Junior Middle English Class from the Perspective of Life-orientation

    Institute of Scientific and Technical Information of China (English)

    FANG Jin-ming

    2014-01-01

    The regression of instruction to life raises as a developmental tendency of course reform among the world. Emphasis on the connection between instruction and students’lives has become an important aspect of curriculum reform. The student learner’s role and the development of students’potentials in their lives also have been emphasized;all these conceptions provide broad space for the implementation of life-orientation of instruction. Situational teaching emphasizes that students should be re-garded as the nucleus of the class. Through acquiring knowledge by themselves, they can bear the knowledge in their mind and improve their communicating ability. The teaching activity should always obey the rule of students centered and teacher aided and make sure that the teaching atmosphere can be kept in an authentic situation. And the most important thing that will be talk-ed about is how to apply situational teaching in Junior Middle English Class.

  16. Palliative care among heart failure patients in primary care: a comparison to cancer patients using English family practice data.

    Directory of Open Access Journals (Sweden)

    Amy Gadoud

    Full Text Available INTRODUCTION: Patients with heart failure have a significant symptom burden and other palliative care needs often over a longer period than patients with cancer. It is acknowledged that this need may be unmet but by how much has not been quantified in primary care data at the population level. METHODS: This was the first use of Clinical Practice Research Datalink, the world's largest primary care database to explore recognition of the need for palliative care. Heart failure and cancer patients who had died in 2009 aged 18 or over and had at least one year of primary care records were identified. A palliative approach to care among patients with heart failure was compared to that among patients with cancer using entry onto a palliative care register as a marker for a palliative approach to care. RESULTS: Among patients with heart failure, 7% (234/3 122 were entered on the palliative care register compared to 48% (3 669/7 608 of cancer patients. Of heart failure patients on the palliative care register, 29% (69/234 were entered onto the register within a week of their death. CONCLUSIONS: This confirms that the stark inequity in recognition of palliative care needs for people with heart failure in a large primary care dataset. We recommend a move away from prognosis based criteria for palliative care towards a patient centred approach, with assessment of and attention to palliative needs including advance care planning throughout the disease trajectory.

  17. Clinical Cancer Registries - Are They Up for Health Services Research?

    Science.gov (United States)

    Pobiruchin, Monika; Bochum, Sylvia; Martens, Uwe M; Schramm, Wendelin

    2016-01-01

    Clinical cancer registries are a valuable data source for health services research (HSR). HSR is in need of high quality routine care data for its evaluations. However, the secondary use of routine data - such as documented cancer cases in a disease registry - poses new challenges in terms of data quality, IT-management, documentation processes and data privacy. In the clinical cancer registry Heilbronn-Franken, real-world data from the Giessen Tumor Documentation System (GTDS) was utilized for analyses of patients' disease processes and guideline adherence in follow-up care. A process was developed to map disease state definitions to fields of the GTDS database and extract patients' disease progress information. Thus, the disease process of sub-cohorts could be compared to each other, e.g., comparison of disease free survival of HER2 (human epidermal growth factor receptor 2)-positive and -negative women who were treated with Trastuzumab, a targeted therapy applied in breast cancer. In principle, such comparisons are feasible and of great value for HSR as they depict a routine care setting of a diverse patient cohort. Yet, local documentation practice, missing flow of information from external health care providers or small sub-cohorts impede the analyses of clinical cancer registries data bases and usage for HSR. PMID:27577380

  18. ENRICH Forum: Ethical aNd Regulatory Issues in Cancer ResearcH

    Science.gov (United States)

    ENRICH Forum: Ethical aNd Regulatory Issues in Cancer ResearcH, designed to stimulate dialogue on ethical and regulatory issues in cancer research and promote awareness of developing policies and best practices.

  19. English Corner

    Institute of Scientific and Technical Information of China (English)

    陶然; 刘之定

    2000-01-01

    There is an English corner in the August 1st Park in Nanchang. You will find it near the bridge. Some young people go there to practise English. There are primary school students, junior middle school students, senior high school students, college students and others have jobs. In the English corner everyone must speak English loudly. They talk about study,

  20. World Englishes

    Institute of Scientific and Technical Information of China (English)

    张严心; 周丽

    2014-01-01

    In the current days, the search for information and the need for global communication have already promoted English from being the language of people in different countries as the international language. This essay will give some arguments about the inevitability of variety of world Englishes and its characteristics, and then explain that what Standard English is and examples about the standards in English.

  1. Microteaching in Sports English

    Institute of Scientific and Technical Information of China (English)

    李晖

    2015-01-01

    The benefit of microteaching has been recognized in many fields.But it remains a research gap in sports English teaching.The ex-periment proved it an effective way in helping students to acquire knowledge and skills in classroom observation and practice of sports English.

  2. The Ideological Construction of English: A Critical Review on the Discourse of English in East Asia

    Science.gov (United States)

    Lin, Han-Yi

    2014-01-01

    This research investigates the ideological character of the English language in East Asia. It focuses on the prevailing beliefs, values and propositions relating to English as a global language and the spread of English in the non-English East Asian countries, namely China, Japan, South Korea and Taiwan. By analyzing how English is presented in…

  3. A research on the enhancement of research management efficiency for the division of research, Korea cancer center hospital

    International Nuclear Information System (INIS)

    The research activities of Korea Cancer Center Hospital have increased for the past a few years just in proportion to the increase of research budget, but the assisting manpower of the office of research management has never been increased and the indications are that the internal and external circumstances will not allow the recruitment for a fairly long time. It has, therefore, become inevitable to enhance the work efficiency of the office by analyzing the administrative research assistance system, finding out problems and inefficiency factors, and suggesting possible answers to them. The office of research management and international cooperation has conducted this research to suggest possible ways to facilitate the administrative support for the research activities of Korea Cancer Center Hospital By analyzing the change of research budget, organization of the division of research and administrative support, manpower, and the administrative research supporting system of other institutes, we suggested possible ways to enhance the work efficiency for administrative research support and developed a relative database program. The research report will serve as a data for the organization of research support division when the Radiation Medicine Research Center is established. The database program has already been used for research budget management

  4. Recent translational research: computational studies of breast cancer

    OpenAIRE

    Demicheli, Romano; Hrushesky, William; Speer, John; Swartzendruber, Douglas; Wardwell, Robert; Retsky, Michael W

    2004-01-01

    The combination of mathematics – queen of sciences – and the general utility of computers has been used to make important inroads into insight-providing breast cancer research and clinical aids. These developments are in two broad areas. First, they provide useful prognostic guidelines for individual patients based on historic evidence. Second, by suggesting numeric tumor growth laws that are correlated to clinical parameters, they permit development of biologically relevant theories and comp...

  5. NanoParticle Ontology for Cancer Nanotechnology Research

    OpenAIRE

    Thomas, Dennis G.; Pappu, Rohit V.; Baker, Nathan A.

    2010-01-01

    Data generated from cancer nanotechnology research are so diverse and large in volume that it is difficult to share and efficiently use them without informatics tools. In particular, ontologies that provide a unifying knowledge framework for annotating the data are required to facilitate the semantic integration, knowledge-based searching, unambiguous interpretation, mining and inferencing of the data using informatics methods. In this paper, we discuss the design and development of NanoParti...

  6. Intercultural competence of first year students of English at the Faculty of Education, Masaryk University: a report of research

    Directory of Open Access Journals (Sweden)

    Zerzová Jana

    2016-05-01

    Full Text Available The article presents the initial stage of research conducted at the Department of English Language and Literature at the Faculty of Education, Masaryk University in Brno. The aim of the research is to examine the departmental students’ intercultural competence (IC at the beginning of their studies (autumn 2011, compare it with their level of IC at the end of their studies (autumn 2016 and investigate the influences that played a role in their IC development. In this paper, only the initial stage of the research is presented, i.e. examining the students’ IC at the beginning of the studies. The Intercultural Development Inventory®, version 3, was used for the purposes of the research. Since this instrument is not currently being used for academic or corporate purposes in the Czech (or Slovak Republic, a secondary aim of the article is to introduce it to the wider academic community. The results indicate that students tend to overestimate their level of IC, and find themselves in ethnocentric stages of intercultural development at the beginning of their university studies.

  7. Funding Opportunities Available for Innovative SBIR Development - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    Does your small business need early-stage financing to take its cancer research to the next level? The National Cancer Institute Small Business Innovation Research (NCI SBIR) Development Center has released $5 million for new contract funding opportunities to support cancer research and technology development in key emerging areas of need.

  8. Motivating teachers in the developing world: Insights from research with English language teachers in Oman

    Science.gov (United States)

    Wyatt, Mark

    2013-07-01

    According to some commentators, targets set by the international community for bringing education to all children in developing countries are threatened by a teacher motivation crisis. For this crisis to be addressed, challenges to the motivation of teachers in such contexts need to be understood from perspectives both theoretical and comparative. Thus an analysis is required of the changes that have taken place particularly in countries whose education systems have developed rapidly in recent decades. Case studies of motivated teacher behaviour in such national contexts might be of relevance to educational reformers. Drawing upon the tenets of self-determination theory (SDT), this article begins by discussing the nature of the reported teacher motivation crisis in the developing world more generally. It then focuses on the Sultanate of Oman, highlighting recent historical developments there. Having thus set the scene, the author considers the extent to which negative environmental influences on teacher motivation in Oman have been addressed and then looks for evidence of intrinsic motivation in case studies of Omani English teachers. Returning to the developing world more generally, conclusions focus on how teachers' psychological needs for competence, autonomy and relatedness can be met through educational policies that reduce negative influences on teacher motivation and provide both inspiring professional development opportunities and work environments characterised by respect.

  9. Technical phosphoproteomic and bioinformatic tools useful in cancer research

    Directory of Open Access Journals (Sweden)

    López Elena

    2011-10-01

    Full Text Available Abstract Reversible protein phosphorylation is one of the most important forms of cellular regulation. Thus, phosphoproteomic analysis of protein phosphorylation in cells is a powerful tool to evaluate cell functional status. The importance of protein kinase-regulated signal transduction pathways in human cancer has led to the development of drugs that inhibit protein kinases at the apex or intermediary levels of these pathways. Phosphoproteomic analysis of these signalling pathways will provide important insights for operation and connectivity of these pathways to facilitate identification of the best targets for cancer therapies. Enrichment of phosphorylated proteins or peptides from tissue or bodily fluid samples is required. The application of technologies such as phosphoenrichments, mass spectrometry (MS coupled to bioinformatics tools is crucial for the identification and quantification of protein phosphorylation sites for advancing in such relevant clinical research. A combination of different phosphopeptide enrichments, quantitative techniques and bioinformatic tools is necessary to achieve good phospho-regulation data and good structural analysis of protein studies. The current and most useful proteomics and bioinformatics techniques will be explained with research examples. Our aim in this article is to be helpful for cancer research via detailing proteomics and bioinformatic tools.

  10. Technical phosphoproteomic and bioinformatic tools useful in cancer research.

    Science.gov (United States)

    López, Elena; Wesselink, Jan-Jaap; López, Isabel; Mendieta, Jesús; Gómez-Puertas, Paulino; Muñoz, Sarbelio Rodríguez

    2011-01-01

    Reversible protein phosphorylation is one of the most important forms of cellular regulation. Thus, phosphoproteomic analysis of protein phosphorylation in cells is a powerful tool to evaluate cell functional status. The importance of protein kinase-regulated signal transduction pathways in human cancer has led to the development of drugs that inhibit protein kinases at the apex or intermediary levels of these pathways. Phosphoproteomic analysis of these signalling pathways will provide important insights for operation and connectivity of these pathways to facilitate identification of the best targets for cancer therapies. Enrichment of phosphorylated proteins or peptides from tissue or bodily fluid samples is required. The application of technologies such as phosphoenrichments, mass spectrometry (MS) coupled to bioinformatics tools is crucial for the identification and quantification of protein phosphorylation sites for advancing in such relevant clinical research. A combination of different phosphopeptide enrichments, quantitative techniques and bioinformatic tools is necessary to achieve good phospho-regulation data and good structural analysis of protein studies. The current and most useful proteomics and bioinformatics techniques will be explained with research examples. Our aim in this article is to be helpful for cancer research via detailing proteomics and bioinformatic tools. PMID:21967744

  11. An Update on Immunohistochemistry in Translational Cancer Research

    Directory of Open Access Journals (Sweden)

    Zonggao Shi

    2015-01-01

    Full Text Available Immunohistochemistry (IHC takes advantage of the specific binding between antigen and antibody to measure the presence and abundance of antigen while simultaneously providing morphologic context on a tissue section. Since the revolutionary application of heat-induced epitope retrieval methods on formalin-fixed paraffin-embedded tissues, which started in early 1990s, IHC has been routinely used in diagnostic pathology. This approach has also enabled mining of the rich archives of pathologic specimens for exploration in translational cancer research. Newer IHC biomarkers are being continuously found as aids in differential diagnosis, prediction of outcome or response to molecular-targeted therapies. These are prime examples for translational cancer research. The last decade has witnessed some significant improvements in the use of this technology. This review provides an overview on the current status of IHC as applied in translational cancer research, commenting on the underlying principles in specimen preparation, reagent choice, staining procedure, and results evaluation so that both beginners and seasoned users could appreciate the key factors and benefit from this update.

  12. Frederick National Lab and the Pancreatic Cancer Action Network Award Fellowships for KRAS Research | Poster

    Science.gov (United States)

    By Nancy Parrish, Staff Writer The Frederick National Laboratory for Cancer Research (FNLCR) recently formed a partnership with the Pancreatic Cancer Action Network (PanCAN) to award a one-year fellowship to two scientists whose research will help lead to new therapies for pancreatic cancer. The scientists will focus on KRAS, a gene in the RAS family that is mutated in 95 percent of pancreatic cancers, according to the National Cancer Institute (NCI).

  13. Consumer input into research: the Australian Cancer Trials website

    Directory of Open Access Journals (Sweden)

    Butow Phyllis N

    2011-06-01

    Full Text Available Abstract Background The Australian Cancer Trials website (ACTO was publicly launched in 2010 to help people search for cancer clinical trials recruiting in Australia, provide information about clinical trials and assist with doctor-patient communication about trials. We describe consumer involvement in the design and development of ACTO and report our preliminary patient evaluation of the website. Methods Consumers, led by Cancer Voices NSW, provided the impetus to develop the website. Consumer representative groups were consulted by the research team during the design and development of ACTO which combines a search engine, trial details, general information about trial participation and question prompt lists. Website use was analysed. A patient evaluation questionnaire was completed at one hospital, one week after exposure to the website. Results ACTO's main features and content reflect consumer input. In February 2011, it covered 1, 042 cancer trials. Since ACTO's public launch in November 2010, until the end of February 2011, the website has had 2, 549 new visits and generated 17, 833 page views. In a sub-study of 47 patient users, 89% found the website helpful for learning about clinical trials and all respondents thought patients should have access to ACTO. Conclusions The development of ACTO is an example of consumers working with doctors, researchers and policy makers to improve the information available to people whose lives are affected by cancer and to help them participate in their treatment decisions, including consideration of clinical trial enrolment. Consumer input has ensured that the website is informative, targets consumer priorities and is user-friendly. ACTO serves as a model for other health conditions.

  14. Chinese speakers' attitudes towards their own English: ELF or Interlanguage

    OpenAIRE

    Wang, Ying

    2014-01-01

    The globalisation of English has motivated the research into English as a lingua franca (ELF) and the debate concerning non-native English speakers’ (NNESs’) own English. Despite the scholarly justification of NNESs’ variations from native English, how users of non-native Englishes perceive their own English is crucial in the discussion of linguistic pluricentricity. This paper sets out to investigate Chinese speakers’ perceptions of their own English in order to offer insights into this issu...

  15. Cancer Treatment-Related Cardiotoxicity: Understanding the Current State of Knowledge and Developing Future Research Priorities

    Science.gov (United States)

    Cancer Treatment-Related Cardiotoxicity: Understanding the Current State of Knowledge and Developing Future Research Priorities, a 2013 workshop sponsored by the Epidemiology and Genomics Research Program.

  16. Sociological Research on Higher Education in Canada 1970-1980: A Review of Some Main Themes in the English Language Literature.

    Science.gov (United States)

    Pike, Robert M.

    English language sociological research on higher education in Canada from 1970-1980 is reviewed. Functionalists have tended to concentrate upon the task of describing the perceived functions of the educational system in the society and have usually considered major educational change as occurring in response to the requirements of the polity and…

  17. Ethical challenges in conducting clinical research in lung cancer

    Science.gov (United States)

    Tod, Angela M.

    2016-01-01

    The article examines ethical challenges that arise with clinical lung cancer research focusing on design, recruitment, conduct and dissemination. Design: problems related to equipoise can arise in lung cancer studies. Equipoise is an ethics precondition for RCTs and exists where there is insufficient evidence to decide which of two or more treatments is best. Difficulties arise in deciding what level of uncertainty constitutes equipoise and who should be in equipoise, for example, patients might not be even where clinicians are. Patient and public involvement (PPI) can reduce but not remove the problems. Recruitment: (I) lung cancer studies can be complex, making it difficult to obtain good quality consent. Some techniques can help, such as continuous consent. But researchers should not expect consent to be the sole protection for participants’ welfare. This protection is primarily done elsewhere in the research process, for example, in ethics review; (II) the problem of desperate volunteers: some patients only consent to a trial because it gives them a 50/50 option of the treatment they want and can be disappointed or upset if randomised to the other arm. This is not necessarily unfair, given clinical equipoise. However, it should be avoided where possible, for example, by using alternative trial designs; (III) the so-called problem of therapeutic misconception: this is the idea that patients are mistaken if they enter trials believing this to be in their clinical best interest. We argue the problem is misconceived and relates only to certain health systems. Conduct: lung cancer trials face standard ethical challenges with regard to trial conduct. PPI could be used in decisions about criteria for stopping rules. Dissemination: as in other trial areas, it is important that all results, including negative ones, are reported. We argue also that the role of PPI with regard to dissemination is currently under-developed.

  18. Clinical trials update of the European Organization for Research and Treatment of Cancer Breast Cancer Group

    International Nuclear Information System (INIS)

    The present clinical trial update consists of a review of two of eight current studies (the 10981-22023 AMAROS trial and the 10994 p53 trial) of the European Organization for Research and Treatment of Cancer Breast Cancer Group, as well as a preview of the MIND-ACT trial. The AMAROS trial is designed to prove equivalent local/regional control for patients with proven axillary lymph node metastasis by sentinel node biopsy if treated with axillary radiotherapy instead of axillary lymph node dissection, with reduced morbidity. The p53 trial started to assess the potential predictive value of p53 using a functional assay in yeast in patients with locally advanced/inflammatory or large operable breast cancer prospectively randomised to a taxane regimen versus a nontaxane regimen

  19. Head and neck cancer: from research to therapy and cure.

    Science.gov (United States)

    Varelas, Xaralabos; Kukuruzinska, Maria A

    2014-12-01

    Cumulative findings from many research groups have identified new signaling mechanisms associated with head and neck cancers. We summarize these findings, including discussion of aberrant NOTCH, PI3K, STAT3, immune recognition, oxidative pathway, and regulation of cell cycle and cell death. The genomic landscape of head and neck cancers has been shown to differ depending on human papillomavirus (HPV) status. We discuss studies examining the integration of HPV into genomic regions, as well as the epigenetic alterations that occur in response to HPV infection, and how these may help reveal new biomarker and treatment predictors. The characterization of premalignant lesions is also highlighted, as is evidence indicating that the surgical removal of these lesions is associated with better clinical outcomes. Current surgical methods are also discussed, including several less aggressive approaches such as minimal invasive robotic surgery. While much remains to be done in the fight against head and neck cancer, continued integration of basic research with new treatment options will likely lead to more effective therapeutic strategies directed against this disease. PMID:25532687

  20. A New Phase in Cancer Research at CERN

    CERN Multimedia

    2002-01-01

    The first meeting of the ENLIGHT network, set up to co-ordinate the development of light ion cancer therapy projects in Europe, took place at CERN last week. This is a form of therapy ideally suited to the treatment of deep-seated tumours and those near critical organs. Hans Hoffmann, Director for Technology transfer and scientific computing, and Director General Luciano Maiani during the opening of the first meeting of the ENLIGHT network that was held at CERN last week. The fruit of several years of work, this meeting offers new hope for the treatment of certain types of cancer. Around 70 specialists, including radiotherapists, oncologists, physicists and engineers, got together at CERN for the first meeting of a European cancer therapy research network named ENLIGHT (European Network for research in LIGHt ion Therapy(1)). This initiative, headed by oncologists and funded by the European Commission, aims to promote the development of light ion (hadron) therapy projects. The choice of CERN as a venue for ...

  1. The Role Transform for the English Teaching Researchers with the Sense of the New Curriculum

    Institute of Scientific and Technical Information of China (English)

    ZhangQiao'an

    2004-01-01

    As the curriculum reform of the basic education is developing in depth continuously, what Changes of the position and function for the teaching and research organizations will take place? And how to propell the curriculttm reform of the basic education is a real problem for every teaching and research worker to concern. During the procedure.edure of the basic

  2. The Nature and Trends in Research and Journal Literature in English Speaking Africa.

    Science.gov (United States)

    Alemna, Anaba; Badu, Ellis

    1994-01-01

    Describes a study that examined three major international library science journals to investigate the nature and trends of library and information science research in Africa from 1990 through 1992. Highlights include status of authors, gender, affiliation, country, types of research, types of cited documents, subjects covered, and most cited…

  3. The Language Lessons around Us: Undergraduate English Pedagogy and Linguistic Landscape Research

    Science.gov (United States)

    Chesnut, MIchael; Lee, Vivian; Schulte, Jenna

    2013-01-01

    This narrative article analyses three Korean undergraduate students' experiences conducting a linguistic landscape research project. Linguistic landscape research, the study of publicly displayed language such as billboards and other signs, is a relatively new area of scholarly interest. However, there has been only limited study of using…

  4. Stages of Prostate Cancer

    Science.gov (United States)

    ... Renal Cell) Cancer Leukemia Lung Cancer Lymphoma Pancreatic Cancer Prostate Cancer Skin Cancer Thyroid Cancer Uterine Cancer All ... Cancer Treatment Prostate Cancer Prevention Genetics of Prostate Cancer Prostate Cancer Screening Research Prostate Cancer Treatment (PDQ®)–Patient ...

  5. Active NCI Community Oncology Research Program Grants | Division of Cancer Prevention

    Science.gov (United States)

    The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

  6. NCI Community Oncology Research Program Clinical Trials | Division of Cancer Prevention

    Science.gov (United States)

    The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

  7. English in Vietnam and Its Features

    Institute of Scientific and Technical Information of China (English)

    李琼璐; 张婷

    2014-01-01

    English spoken by people from different countries takes on different characteristics. Many linguists conducted researches on World Englishes. Focusing on the pronunciation, grammar, vocabulary and literature achievement, these studies present the target English's environment and features. However, there is rare achievement of study.in English in Vietnam. Under the economy boom, Vietnamese government attached importance to the English education, which led to the wide utilization of English. This article analyzes English in Vietnam and its features , including pronunciation, grammar and vocabulary, in the hope of making complements to world Englishes.

  8. Research Progress of Lung Cancer with Leptomeningeal Metastasis

    Directory of Open Access Journals (Sweden)

    Chunhua MA

    2014-09-01

    Full Text Available Leptomeningeal metastases is one of the most serious complications of lung cancer, the patients with poor prognosis. Leptomeningeal metastasis in patients with lack specificity of clinical manifestations. The main clinical performance are the damage of cerebral symptoms, cranial nerve and spinal nerve. The diagnosis primarily based on the history of tumor, clinical symptoms, enhance magnetic resnance image (MRI scan and cerebrospinal fluid cytology. In recent years, new ways of detecting clinically, significantly increase the rate of early detection of leptomeningeal metastases. The effect of comprehensive treatments are still sad. The paper make a review of research progress in pathologic physiology, clinical manifestations, diagnosis methods and treatments of lung cancer with leptomeningeal metastases.

  9. Recruiting young adult cancer survivors for behavioral research.

    Science.gov (United States)

    Rabin, Carolyn; Horowitz, Santina; Marcus, Bess

    2013-03-01

    Young adults have been dramatically underrepresented in cancer survivorship research. One contributing factor is the difficulty recruiting this population. To identify effective recruitment strategies, the current study assessed the yield of strategies used to recruit young survivors for an exercise intervention including: clinic-based recruitment, recruitment at cancer-related events, mailings, telephone-based recruitment, advertising on the internet, radio, television and social networking media, distributing brochures and word-of-mouth referrals. When taking into account the strategies for which we could track the number of survivors approached, recruitment at an oncology clinic was the most productive: 38 % of those approached were screened and 8 % enrolled. When evaluating which strategy yielded the greatest percentage of the sample, however, mailings were the most productive. Given widespread use of the internet and social networking by young adults, investigators should also consider these low-cost recruitment strategies. PMID:22810954

  10. Recent progress in 8igenomic research of liver cancer

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Along the course of occurrence and development of liver cancer,the corresponding somatic cells accumulate some important genetic variations.These variations may be divided into two categories.For the genetic changes closely related to etiology of liver cancer,the well-known cases include insertion and integration of the hepatitis B virus(HBV) DNA after infection,and mutations at site 249 of the tumor suppressor gene p53 induced by exposure to aflatoxin B1.The secondary genetic changes include amplification and deletion of certain chromosome regions,mutations in p53 at the sites other than 249,as well as the mutational activation of the Wnt/β-catenin signal pathway.The tumor cells with these genetic variations may gradually become the dominant clones under evolutionary selection.Besides,identification of genetic susceptible against risk of liver malignancy is also an important aspect of research in this field.

  11. James P. Allison received the 2014 Szent-Györgi Prize for Progress in Cancer Research

    OpenAIRE

    Jie Zhao; Peter Scully; Sujuan Ba

    2014-01-01

    The Szent-Gyorgyi Prize for Progress in Cancer Research is a prestigious scientific award established by the National Foundation for Cancer Research (NFCR)-a leading cancer research charitable organization in the United States that is committed to supporting innovative cancer research on the global scale that aims to cure cancer. Each year, the Szent-Gyorgyi Prize honors an outstanding researcher whose original discoveries have expanded our understanding of cancer and resulted in notable adv...

  12. British or American English? A Survey on Speech

    OpenAIRE

    Svanhildur Sif Halldórsdóttir 1985

    2014-01-01

    The aim of this survey is to determine whether Icelanders use more British English or American English in their speech. British English is taught in most compulsory and secondary schools in Iceland but most English input comes from the United States. The research shows that males are more likely to use British English in their speech than females. They are also better at determining whether a sentence is written in British English or American English. The research indicates that older partici...

  13. The Danish Integrated Database for Labor Market Research: Towards Demystification for the English Speaking Audience

    OpenAIRE

    Bram Timmermans

    2010-01-01

    An increasing number of studies, in a wide range of disciplines, make use of so-called linked employer-employee databases. These detailed databases are only available in a limited number of countries. Denmark is one of the countries that makes this data available to researchers that are connected to a Danish research institute. Due to the sensitivity of the data, access is only granted after a thorough screening process and under strict conditions. Nevertheless, there is an international inte...

  14. The Validity of SAT® Scores in Predicting First-Year Mathematics and English Grades. Research Report 2012-1

    Science.gov (United States)

    Mattern, Krista D.; Patterson, Brian F.; Kobrin, Jennifer L.

    2012-01-01

    This study examined the validity of the SAT for predicting performance in first-year English and mathematics courses. Results reveal a significant positive relationship between SAT scores and course grades, with slightly higher correlations for mathematics courses compared to English courses. Correlations were estimated by student characteristics…

  15. Research and Practice of the System of Computer-assisted Oral English Test on a Large Scale

    Institute of Scientific and Technical Information of China (English)

    Bo Jiang

    2012-01-01

      The establishment of computer-assisted oral test system is one way to improve college students’ English communication skills. This thesis gives a brief analysis of how to set up a scientific system in colleges from the characters of oral activities,oral ability and its features,the patterns of English oral test and the abilities tested.

  16. English as an Additional Language--A Genealogy of Language-in-Education Policies and Reflections on Research Trajectories

    Science.gov (United States)

    Leung, Constant

    2016-01-01

    The school population in England is linguistically diverse; according to official data, over one million pupils do not speak English as their first language. All teachers are expected to support English as an additional language (EAL) development as part of their professional responsibility. At the same time, there has been little specific…

  17. Individual Breast Cancer risk assessment in Underserved Populations: Integrating empirical Bioethics and Health Disparities Research

    OpenAIRE

    Anderson, Emily E.; Hoskins, Kent

    2012-01-01

    Research suggests that individual breast cancer risk assessment may improve adherence to recommended screening and prevention guidelines, thereby decreasing morbidity and mortality. Further research on the use of risk assessment models in underserved minority populations is critical to informing national public health efforts to eliminate breast cancer disparities. However, implementing individual breast cancer risk assessment in underserved patient populations raises particular ethical issue...

  18. Science, Science Signaling, and Science Translational Medicine – AAAS Special Collection on Cancer Research, March 2011

    Directory of Open Access Journals (Sweden)

    Forsythe, Katherine H.

    2011-10-01

    Full Text Available The National Cancer Act, signed in 1971, aimed to eliminate cancer deaths through a massive increase in research funding. The American Association for the Advancement of Science, the publisher of Science, Science Signaling, and Science Translational Medicine, observed the 40th anniversary of the Cancer Act in 2011, with special research articles and features, found in all three journals, on the state of cancer research 40 years later. This collection of articles explores both breakthroughs and the challenges in cancer research over the last four decades, and lets us know what we might expect in the future.

  19. Differential Regulatory Analysis Based on Coexpression Network in Cancer Research.

    Science.gov (United States)

    Li, Junyi; Li, Yi-Xue; Li, Yuan-Yuan

    2016-01-01

    With rapid development of high-throughput techniques and accumulation of big transcriptomic data, plenty of computational methods and algorithms such as differential analysis and network analysis have been proposed to explore genome-wide gene expression characteristics. These efforts are aiming to transform underlying genomic information into valuable knowledges in biological and medical research fields. Recently, tremendous integrative research methods are dedicated to interpret the development and progress of neoplastic diseases, whereas differential regulatory analysis (DRA) based on gene coexpression network (GCN) increasingly plays a robust complement to regular differential expression analysis in revealing regulatory functions of cancer related genes such as evading growth suppressors and resisting cell death. Differential regulatory analysis based on GCN is prospective and shows its essential role in discovering the system properties of carcinogenesis features. Here we briefly review the paradigm of differential regulatory analysis based on GCN. We also focus on the applications of differential regulatory analysis based on GCN in cancer research and point out that DRA is necessary and extraordinary to reveal underlying molecular mechanism in large-scale carcinogenesis studies. PMID:27597964

  20. Differential Regulatory Analysis Based on Coexpression Network in Cancer Research

    Directory of Open Access Journals (Sweden)

    Junyi Li

    2016-01-01

    Full Text Available With rapid development of high-throughput techniques and accumulation of big transcriptomic data, plenty of computational methods and algorithms such as differential analysis and network analysis have been proposed to explore genome-wide gene expression characteristics. These efforts are aiming to transform underlying genomic information into valuable knowledges in biological and medical research fields. Recently, tremendous integrative research methods are dedicated to interpret the development and progress of neoplastic diseases, whereas differential regulatory analysis (DRA based on gene coexpression network (GCN increasingly plays a robust complement to regular differential expression analysis in revealing regulatory functions of cancer related genes such as evading growth suppressors and resisting cell death. Differential regulatory analysis based on GCN is prospective and shows its essential role in discovering the system properties of carcinogenesis features. Here we briefly review the paradigm of differential regulatory analysis based on GCN. We also focus on the applications of differential regulatory analysis based on GCN in cancer research and point out that DRA is necessary and extraordinary to reveal underlying molecular mechanism in large-scale carcinogenesis studies.

  1. The research on English Teaching in the network environment%网络环境中英语教学的探究

    Institute of Scientific and Technical Information of China (English)

    石英红

    2013-01-01

    The information network teaching has been more and more schools and social concerns of English teaching in today’s highly information-oriented,how to make the students to make good use of the network to master the English language,English educators face the issue.Network teaching is a new teaching model and means it will have a significant impact on the traditional English teaching.A wealth of teaching resources in the network environment,open teaching mode provides a good environment for English teaching. English Teaching of reading,writing,heard and research learning a new impetus to the development in IT support,so that the students‘enthusiasm for learning has been an unprecedented increase and converted quickly improve students’ English literacy.Network technology and English curriculum integration has gradually infiltrated into the teaching of various disciplines,educators are teaching theory and practice,delve into the network context of instructional design,teaching strategies,to form a new teaching model to promote English teaching changes.From English teaching mode to the network,the changes in the pattern of English learners,English teaching changes in the means of three levels of English teaching of the network information analysis and elaboration.%  网络信息化教学已越来越受到学校和社会的关注,而英语教学在高度信息化的今天,怎样使学生运用好网络来掌握英语,就成为英语教育工作者所要面对的课题。网络教学是全新的教学模式和手段,它将对传统的英语教学产生重大的影响。网络环境下丰富的教学资源、开放的教学模式为英语教学提供了良好的环境。英语教学中学生的阅读、写作、听说和研究性学习等内容在信息技术的支持下获得了新的发展动力,使学生的学习积极性得到了空前的提高并转化为学生英语素养的迅速提高。网络技术与英语课程的整合已经逐步渗入到

  2. Cancer survivorship--genetic susceptibility and second primary cancers: research strategies and recommendations.

    OpenAIRE

    Travis, Lois B.; Rabkin, Charles S.; Brown, Linda Morris; Allan, James M.; Alter, Blanche P.; Ambrosone, Christine B.; Begg, Colin B.; Caporaso, Neil; Chanock, Stephen; DeMichele, Angela; Figg, William Douglas; Mary K Gospodarowicz; Hall, Eric J.; Hisada, Michie; Inskip, Peter

    2006-01-01

    KEYWORDS - CLASSIFICATION: adverse effects;Antineoplastic Agents;biomarkers of individual susceptibility: validation;Biotechnology;cancer epidemiology;chemically induced;Carcinogens;Case-Control Studies;Clinical Trials;Cohort Studies;Congresses;drug therapy;epidemiology;etiology;genetics;Genetic Predisposition to Disease;Humans;methods;mortality;Medical Informatics;Multicenter Studies;Neoplasms;Neoplasms,Radiation-Induced;Neoplasms,Second Primary;radiotherapy;Radiotherapy;Registries;Research;...

  3. English Teaching Strategies Research--Based on the Vocational High School Art Students’Learning Style

    Institute of Scientific and Technical Information of China (English)

    Sun Jianxia

    2014-01-01

    Diagnosing learners' learning style is meaningful for “student-centered” teaching mode and individualized teaching.But the teaching strategies based on the students' learning style should gain the same attention.Seldom do researchers regard vocational high school art students as their subjects.Using Reid’s Perceptual Learning Style Survey as the research instrument, this paper viewed vocational high school art students as the subjects;the purpose is to find some effective strategies to teach art students of vocational high school well.

  4. An Action Research on How to Improve English Reading Abilities of Students in High School

    Institute of Scientific and Technical Information of China (English)

    王文韬; 于月清; 程雯

    2014-01-01

    This dissertation is based on the characteristics of high school students' reading ability and the latest tendency of curriculum reforms of nation to carry out my action research. Firstly, propose a hypothetical analysis and utilize questionnaire, interviewing, teacher log and student log to collect and analyze information with the aim of verifying the hypothesis. Secondly, Work out an effective action research scheme and carry it out. In the process of carrying out the scheme, I reflect and ameliorate my scheme constantly in order to maximize students' reading ability and raise students' speed. This dissertation is divided into six parts.

  5. Bioinformatics resources for cancer research with an emphasis on gene function and structure prediction tools

    Directory of Open Access Journals (Sweden)

    Daisuke Kihara

    2006-01-01

    Full Text Available The immensely popular fields of cancer research and bioinformatics overlap in many different areas, e.g. large data repositories that allow for users to analyze data from many experiments (data handling, databases, pattern mining, microarray data analysis, and interpretation of proteomics data. There are many newly available resources in these areas that may be unfamiliar to most cancer researchers wanting to incorporate bioinformatics tools and analyses into their work, and also to bioinformaticians looking for real data to develop and test algorithms. This review reveals the interdependence of cancer research and bioinformatics, and highlight the most appropriate and useful resources available to cancer researchers. These include not only public databases, but general and specific bioinformatics tools which can be useful to the cancer researcher. The primary foci are function and structure prediction tools of protein genes. The result is a useful reference to cancer researchers and bioinformaticians studying cancer alike.

  6. TRANSLATE: New Strategic Approaches for English Learners

    Science.gov (United States)

    Goodwin, Amanda P.; Jiménez, Robert

    2016-01-01

    This teaching tip shares a research-based instructional model that uses translation to improve the English reading comprehension of English Learners. Within this instruction, English learners work collaboratively in small groups and use translation to facilitate understandings of their required English language arts curriculum. Students are taught…

  7. Statistical methods in cancer research: Investigating localized clusters of disease

    International Nuclear Information System (INIS)

    The search for 'clusters' of cancer cases has been a major feature of epidemiological research, and has come to the attention of the public following the publicity given to some childhood leukemia cases in villages surrounding the Sellafield reprocessing plant in England. Clustering is a poorly defined concept. Modern methodological developments have involved two distinct methods, quadrat counts and distance methods. Although statistical methods can indicate (with some error) whether clustering is present, they provide little information as to the real cause. Putative causes will always require further, more specific, studies before the results become meaningful. 5 refs

  8. Cancer research in Brazil - stuck in second gear?

    Directory of Open Access Journals (Sweden)

    A.P. Lepique

    2015-02-01

    Full Text Available This article describes the main issues regarding clinical cancer research in Brazil, including both the opportunities and the hurdles. Scientists and clinicians in this field had the opportunity to talk to regulatory agencies and to the Health Ministry representative at a meeting held in the State of Rio de Janeiro, Brazil, in April 2014. Our conclusions are that we do indeed have opportunities; however, we need to move forward regarding partnerships between academia and industry, increase the availability of funding, and provide easier navigation through the regulatory processes.

  9. [Current status of castration-resistant prostate cancer translational research].

    Science.gov (United States)

    Maeno, Atsushi; Habuchi, Tomonori

    2016-01-01

    Recently, new drugs including abiraterone and enzalutamide have been able to be used for castration resistant prostate cancer(CRPC) patients. However, a subset of these patients who receive the new drugs does not response to the therapies. Furthermore, most patients who initially response to the drugs, progress to secondary resistance eventually. Therefore, it is important to investigate a novel therapeutic target and a novel treatment-selection marker for CRPC. In this review, we focused on AR-V7, TMPRSS2-ERG fusion gene and EP4 antagonist as representative translational researches. PMID:26793877

  10. Radiological English

    International Nuclear Information System (INIS)

    The book is an introductory book to radiological English on the basis that there are a lot of radiologists, radiology residents, radiology nurses, radiology students, and radiographers worldwide whose English level is indeterminate because their reading skills are much higher than their fluency. It is intended to help those health care professionals who need English for their work but do not speak English on a day-to-day basis. (orig.)

  11. Radiological English

    Energy Technology Data Exchange (ETDEWEB)

    Ribes, R. [Hospital Reina Sofia, Cordoba (Spain). Servicio de Radiologia; Ros, P.R. [Harvard Medical School, Boston, MA (United States). Div. of Radiology

    2007-07-01

    The book is an introductory book to radiological English on the basis that there are a lot of radiologists, radiology residents, radiology nurses, radiology students, and radiographers worldwide whose English level is indeterminate because their reading skills are much higher than their fluency. It is intended to help those health care professionals who need English for their work but do not speak English on a day-to-day basis. (orig.)

  12. Analyzing research article introductions by Iranian and native English-speaking authors of Applied Linguistics

    Directory of Open Access Journals (Sweden)

    Shahriari Ahmadi, Hesamoddin

    2013-01-01

    Full Text Available Considering the role of academic writing in the dissemination of research findings among members of scientific communities, efforts have been made by language specialists to achieve a more detailed understanding of this register, with hopes that the derived features could then be used to teach researchers, writing in a second/foreign language, to more effectively communicate the results of their studies. This study sets out to achieve a similar goal through the analysis of research article introductions in terms of the frequency and function of their lexical bundles. To this end, a corpus of 200 research article introductions by published authors in the field of Applied Linguistics was compared to a similar corpus by Iranian, non-native writers of the same field. The findings reveal that Iranian authors use more 4-word lexical bundles in their writing compared to their native-speaker counterparts. Syntactic and functional differences between the two corpora are introduced and implications for academic writing instructors are discussed in detail.

  13. Designing a Qualitative Research for Evaluation of English for Academic Purposes Activity in Teacher Education

    Science.gov (United States)

    Zascerinska, Jelena

    2010-01-01

    Competence-based teacher education provides new knowledge within the knowledge triangle of education, research and innovation. Communicative competence is of the greatest importance which individuals need for personal fulfilment and development, active citizenship, social inclusion and employment (European Commission, 2004). The successful…

  14. Mouse Monoclonal Antibodies for Liver Cancer Research | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The National Cancer Institute Laboratory of Molecular Biology seeks parties for collaborative research to co-develop and commercialize antibody drug/toxin conjugates as liver cancer therapy and diagnostics.

  15. Bridging the Critical Chasm Between Service and Research: The Cancer Information Service’s Collaboratory

    OpenAIRE

    Squiers, Linda; Bush, Nigel; Vanderpool, Robin; Cofta-Woerpel, Ludmila; Fabrizio, Cecilia

    2007-01-01

    As a collaboratory for cancer communication and education research, the National Cancer Institute’s (NCIs) Cancer Information Service (CIS) is in an ideal position to bridge the critical chasm that exists between service and research. This article describes the CIS’ current research program as well as the CIS Research Agenda launched in 2005. The CIS’ progress in developing and supporting recently funded studies that address this agenda is detailed. The unique resources and opportunities avai...

  16. Leadership of Schools as Research-Led Organisations in the English Educational Environment: Cultivating a Research-Engaged School Culture

    Science.gov (United States)

    Godfrey, David

    2016-01-01

    This article examines the conditions for the growth and expansion of research-engaged schools in England. The current policy climate is seeing a rapid growth of autonomous schools coupled with the continuing tendency to hold schools to account for overall student educational attainment indicators. Within this context, the article begins by…

  17. Impact of biospecimens handling on biomarker research in breast cancer

    Directory of Open Access Journals (Sweden)

    Callari Maurizio

    2009-11-01

    Full Text Available Abstract Background Gene expression profiling is moving from the research setting to the practical clinical use. Gene signatures able to correctly identify high risk breast cancer patients as well as to predict response to treatment are currently under intense investigation. While technical issues dealing with RNA preparation, choice of array platforms, statistical analytical tools are taken into account, the tissue collection process is seldom considered. The time elapsed between surgical tissue removal and freezing of samples for biological characterizations is rarely well defined and/or recorded even for recently stored samples, despite the publications of standard operating procedures for biological sample collection for tissue banks. Methods Breast cancer samples from 11 patients were collected immediately after surgical removal and subdivided into aliquots. One was immediately frozen and the others were maintained at room temperature for respectively 2, 6 and 24 hrs. RNA was extracted and gene expression profile was determined using cDNA arrays. Phosphoprotein profiles were studied in parallel. Results Delayed freezing affected the RNA quality only in 3 samples, which were not subjected to gene profiling. In the 8 breast cancer cases with apparently intact RNA also in sample aliquots frozen at delayed times, 461 genes were modulated simply as a function of freezing timing. Some of these genes were included in gene signatures biologically and clinically relevant for breast cancer. Delayed freezing also affected detection of phosphoproteins, whose pattern may be crucial for clinical decision on target-directed drugs. Conclusion Time elapsed between surgery and freezing of samples appears to have a strong impact and should be considered as a mandatory variable to control for clinical implications of inadequate tissue handling.

  18. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Treatment Pediatric Supportive Care Unusual Cancers of Childhood Treatment Research Metastatic Cancer Metastatic Cancer Research Common Cancer Types Recurrent Cancer Common Cancer Types Bladder Cancer Breast Cancer Colorectal Cancer Kidney (Renal Cell) Cancer Leukemia ...

  19. Letter from the Director - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The NCI’s Clinical Proteomic Technologies for Cancer (CPTC) initiative is focused on developing a better understanding of cancer biology through the proteomic interrogation of genomically characterized tumors from sources such as The Cancer Genome Atlas.

  20. Linking Genealogical Research to Library and Information Science : Concepts, Perspectives, Considerations [English Brief Adaptation

    OpenAIRE

    Sant-Geronikolou, Lia

    2011-01-01

    This essay is based on views and conclusions on genealogy and its relation to information sciences as shaped during long years of research inspired by both personal and experiental interest in the advanced study of family descent. It was a real challenge that, in order to become objectively comprehensive, I had to go beyond my personal preferences and practices, to the standards and culture of the best field professionals. It was progressively enriched in the process, along with the recons...

  1. Research output and the public health burden of cancer: is there any relationship?

    Science.gov (United States)

    Patafio, F.M.; Brooks, S.C.; Wei, X.; Peng, Y.; Biagi, J.; Booth, C.M.

    2016-01-01

    Purpose The relative distribution of research output across cancer sites is not well described. Here, we evaluate whether the volume of published research is proportional to the public health burden of individual cancers. We also explore whether research output is proportional to research funding. Methods Statistics from the Canadian and American cancer societies were used to identify the top ten causes of cancer death in 2013. All journal articles and clinical trials published in 2013 by Canadian or U.S. authors for those cancers were identified. Total research funding in Canada by cancer site was obtained from the Canadian Cancer Research Alliance. Descriptive statistics and Pearson correlation coefficients were used to describe the relationship between research output, cancer mortality, and research funding. Results We identified 19,361 publications and 2661 clinical trials. The proportion of publications and clinical trials was substantially lower than the proportion of deaths for lung (41% deaths, 15% publications, 16% clinical trials), colorectal (14%, 7%, 6%), pancreatic (10%, 7%, 5%), and gastroesophageal (7%, 5%, 3%) cancers. Conversely, research output was substantially greater than the proportion of deaths for breast cancer (10% deaths, 29% publications, 30% clinical trials) and prostate cancer (8%, 15%, 17%). We observed a stronger correlation between research output and funding (publications r = 0.894, p < 0.001; clinical trials r = 0.923, p < 0.001) than between research output and cancer mortality (r = 0.363, p = 0.303; r = 0.340, p = 0.337). Conclusions Research output is not well correlated with the public health burden of individual cancers, but is correlated with the relative level of research funding. PMID:27122971

  2. An Investigation of English Writing Anxiety Among English Majors

    Institute of Scientific and Technical Information of China (English)

    马星星

    2013-01-01

    With Daly, Horwitz and Y-S-Cheng’s theoretical model of second language writing anxiety as research framework, this thesis surveyed English majors’English writing anxiety. Findings of the present study show that all of the English major stu⁃dents experience English writing anxiety. There is no significant difference in English anxiety among students from three different grades. There is significant difference in English writing anxiety between the students who hold positive attitudes towards English writing and those who hold negative attitudes towards English writing and there is significant difference in English writing anxi⁃ety among students who rated their English writing good, average and bad. Results from the qualitative study show the reasons why there is little difference in English writing anxiety among students from three different grades. What’s more, it is shown that the poor writing skills, cognitive anxiety, test anxiety and erroneous beliefs toward English writing are the main sources of Eng⁃lish writing anxiety.

  3. English For, Not English As.

    Science.gov (United States)

    De Freitas, J. F.; Adkins, P. V. A.

    1981-01-01

    Describes connotations of the phrases, Teaching English as a Foreign language (TEFL) and Teaching English as a Second Language (TESL) in England. Suggests introduction of English for Native Speakers of Other Languages (ENSOL) as a more appropriate term, which would also incorporate Community Language Learning (CLL) procedures. (BK)

  4. American English vs. British English

    Science.gov (United States)

    Shahheidaripour, Gholamabbass

    1997-01-01

    The present study, using a totally direct method, investigates, within the framework of sociolinguistics and foreign language teaching in Iran, whether teachers of English prefer British or American variety of English language, and whether their preference corresponds to their performance on a related test. Thirty Iranian English language teachers…

  5. MIDDLE ENGLISH: ENGLISH OR FRENGLISH?

    OpenAIRE

    L.M. Ikalyuk; U.T. Tatsakovych

    2015-01-01

    The article focuses on a general description of Middle English considering the impact of the French language on its development during this period. Despite an extensive number of French borrowings in different layers of the English language, the language remained English and its predominant features were still those of Germanic origin.

  6. 关于英语生词讲解法的理论研究%Theoretical Research on the Methods of Teaching English Vocabulary

    Institute of Scientific and Technical Information of China (English)

    王晓睿

    2012-01-01

    Among the research on English teaching methods,there is lots of research on the methods of teaching English vocabulary.This study mainly theoretically researches two methods used in common,and reveals the different effects of these two methods on different teaching aims,and the impact on reading comprehension.The author hopes this study would promote more research on teaching vocabularies and teaching methods,which can help students to understand English texts and practice reading comprehension more effectively.%在针对英语教学法的研究中有很多是关于生词讲解法的,本研究主要是针对其中两种常见生词讲解法的理论研究,揭示这两种讲解法对于不同教学目的会起到的不同的作用,以及会对阅读理解产生的影响。希望通过本研究可以促进更多的针对生词讲解法及教学法的研究,从而对英语课文的理解及阅读理解的练习有更大的帮助。

  7. When are breast cancer patients at highest risk of venous thromboembolism: a cohort study using English healthcare data

    OpenAIRE

    Walker, Alex J.; West, Joe; Card, Timothy R; Crooks, Colin J; Kirwan, Cliona C; Grainge, Matthew J

    2015-01-01

    Breast cancer patients are at increased risk of VTE, particularly in the peri-diagnosis period. However, no previous epidemiological studies have investigated the relative impact of breast cancer treatments in a time-dependent manner. We aimed to determine the impact of breast cancer stage, biology and treatment on the absolute and relative risks of VTE, using several recently linked data sources from England. Our cohort comprised 13,202 breast cancer patients from the Clinical Practice Resea...

  8. The European Organization for Research and Treatment of Cancer (EORTC) Quality-of-Life questionnaire cervical cancer module

    DEFF Research Database (Denmark)

    Greimel, Elfriede R; Kuljanic Vlasic, Karin; Waldenstrom, Ann-Charlotte;

    2006-01-01

    BACKGROUND: The authors report on the development and validation of a cervical cancer module for the European Organization for Research and Treatment of Cancer (EORTC) Quality-of-Life (QoL) questionnaire (QLQ), which was designed to assess disease-specific and treatment-specific aspects of Qo......L in patients with cervical cancer. METHODS: The cervical cancer module (EORTC QLQ-CX24) was developed in a multicultural, multidisciplinary setting to supplement the EORTC QLQ-C30 core questionnaire. The QLQ-C30 and the cervical cancer module were administered to 346 patients with cervical cancer who underwent...... of the EORTC QLQ-CX24 module. This newly developed module is a useful instrument for assessing the QoL of patients who are treated for cervical cancer both in clinical trials and in clinical practice....

  9. The Research of the English Majors’Intercultural Communication Competence%英语专业学生跨文化交际能力培养研究

    Institute of Scientific and Technical Information of China (English)

    许晖

    2013-01-01

    The cultivation of intercultural communication competence is particularly important for English majors. However, in the process of English teaching now, the instilment of cultural knowledge is scarce and the schools seldom open intercultural courses. Applying a combination of qualitative and quantitative method, the researcher analyzes the current situation of cultiva⁃tion of English majors’intercultural communication and gives several reasonable suggestions. The conclusion is that the current situation of English major’s intercultural communication cultivation is not optimistic and some adjustments need to be done in the teaching procedure.%  跨文化交际能力的培养对于英语专业的学生来说尤为重要,而现状是英语专业学生的教学过程中,对文化内容的植入较少,也缺少专门的跨文化课程。研究者以定性和定量相结合的方法分析了英语专业跨文化交际能力培养的现状并提出了合理的建议,得出的结论是英语专业学生现阶段跨文化交际能力培养现状不容乐观,需要对教学方法进行相应调整。

  10. Global English and Listening Materials : A Textbook Analysis

    OpenAIRE

    Eggert, Björn

    2009-01-01

    This paper focuses on listening materials used in English language teaching in Sweden, especially in respect to the concept of global English. Global English could briefly be described as the linguistic, cultural, politic, and economic influence of English in the world. This influence concerns two aspects of English, namely the usage of English as a lingua franca in international communications, as well as the great range of English varieties that are used today. The purpose of this research ...

  11. ADVANTAGES AND APPLICATIONS OF TISSUE MICROARRAY TECHNOLOGY ON CANCER RESEARCH

    Institute of Scientific and Technical Information of China (English)

    张喜平; 苏丹; 程琪辉

    2003-01-01

    S To provide evidences for exploiting tissue microarray (TMA) technology, we reviewed advantages and applications of TMA on tumor research. TMA has many advantages, including (1) section from TMA blocks can be utilized for the simultaneous analysis of up to 1,000 different tumors at DNA, RNA or protein level; (2) TMA is highly representative of their donor tissues; (3) TMA can improve conservation of tissue resources and experimental reagents, improve internal experimental control, and increase sample numbers per experiment, and can be used for large-scale, massively parallel in situ analysis; (4) TMA facilitates rapid translation of molecular discoveries to clinical applications. TMA has been applied to tumor research, such as glioma, breast tumor, lung cancer and so on. The development of novel biochip technologies has opened up new possibilities for the high-throughput molecular profiling of human tumors. Novel molecular markers emerging from high-throughput expression surveys could be analyzed on tumor TMA. It is anticipated that TMA, a new member of biochip, will soon become a widely used tool for all types of tissue-based research. TMA will lead to a significant acceleration of the transition of basic research findings into clinical applications.

  12. Culturally tailored cancer communication, education, and research: the highways and back roads of Appalachia.

    Science.gov (United States)

    Dorgan, Kelly A; Hutson, Sadie P; Gerding, Gail; Duvall, Katie L

    2009-04-01

    We seek to start a dialogue about the challenges cancer control researchers and specialists may face in attempting to understand the Appalachians' experience with cancer. Through examples drawn from our own research among Appalachian communities, we discuss the hazards of defining a culture in order to develop culturally tailored cancer control interventions and programs. We also acknowledge that cancer control work in Appalachia requires "cultural mapping," highlighting cultural beliefs, norms, and realities that may be linked to cancer mortality and morbidity. Although cancer control specialists and researchers have to rely on cultural maps, they must also remain critical of such maps. Subsequently, we describe a mapping approach around the metaphor of "signposts," directional indicators that point to broad cultural attributes but do not reduce the culture to a narrow set of traits. The interplay of these signposts ultimately helps cancer educators, communicators, and researchers better understand authentic Appalachia. PMID:19289011

  13. Korean Adults' Attitudes towards Varieties of English

    OpenAIRE

    Kim, Young Soo

    2007-01-01

    This study investigates 43 Korean adults’ attitudes towards native and non-native varieties of English in relation to the perspective of EIL (English as an international language). This study addresses three research questions: 1) do Korean adults prefer certain varieties of English? 2) do Korean adults at least accept non-native varieties of English?, and 3) are Korean adults aware of different varieties of English? In order to examine participants’ language attitudes, this study employed bo...

  14. The English Film Title Translation Strategies

    OpenAIRE

    Xuedong Shi

    2014-01-01

    Based on the research of characteristics, functions, translation principles and methods of English film titles, this paper discusses the English film title translation and mainly focus on English film titles domestication and foreignization translation. Good English film should be attractive, attracting the audience to watch the film. A good English film title has a value of artistic, aesthetic and commercial. Cultural translation leads to translators’ using domestication, foreignizatio...

  15. Researchers Use a Kinome Screen to Identify New Therapeutic Targets | Office of Cancer Genomics

    Science.gov (United States)

    The tumor suppressor p53 is mutated in over 50% of head and neck squamous cell carcinomas (HNSCC), yet there are currently no available therapies to target it. CTD2 researchers at the Fred Hutchison Cancer Research Center hypothesized that HNSCC cancer cells with p53 mutations are dependent on particular kinases for survival. In a study published in Clinical Cancer Research, they sought to identify these kinases using RNAi against known kinase genes in mouse and human cell lines.

  16. Research on Fast Track Surgery Application in Lung Cancer Surgery

    Directory of Open Access Journals (Sweden)

    Kaiyun YANG

    2010-02-01

    Full Text Available Background and objective Fast track surgery (FTS is a systematical method to accelerate the recovery of surgical patients by reducing the physical and mental trauma stress of them. The research is to investigate the feasibility of FTS application in lung cancer surgery. Methods A total of 80 cases of lung cancer patients with single leaf lobotomy resection were randomized into two groups. While the experimental group was treated with the conception of FTS, and the control group was treated with the traditional methods. The incident rate of post-operation pain degrees, telecasts, pleural effusion, the post-operation time stay in hospital time and the total cost during hospitalization in two groups were compared respectively. Results In FTS group: the VAS score of post-operation pain at 1 h, 6 h, 12 h, 24 h and 48 h all significantly decreased compared to the traditional therapy group. The incidence rate of telecast was 10.53%. The incidence rate of pleural effusion was 26.31%. The length of stay after operation was (4±1 d and the total cost was RMB 15 600±7 600. In the control group, the above values were 77.78%, 33.33%, 22.22%, (9±1 d, RMB 23 600±5 400, respectively. The post operation pain (VAS method of FTS group was remarkablely below the control group. There has significant difference of the incident rate of telecasts, stay time in hospital and the total cast in two groups (P < 0.05. No significant difference was observed in the incident rate of pleural effusion. Conclusion The new methods of FTS can apparently accelerates recovery after lung cancer resection, reduces complications, shorten timestay in hospital and cut down the total cost.

  17. Growth Analysis of Cancer Biology Research, 2000-2011

    Directory of Open Access Journals (Sweden)

    Keshava,

    2015-09-01

    Full Text Available Methods and Material: The PubMed database was used for retrieving data on 'cancer biology.' Articles were downloaded from the years 2000 to 2011. The articles were classified chronologically and transferred to a spreadsheet application for analysis of the data as per the objectives of the study. Statistical Method: To investigate the nature of growth of articles via exponential, linear, and logistics tests. Result: The year wise analysis of the growth of articles output shows that for the years 2000 to 2005 and later there is a sudden increase in output, during the years 2006 to 2007 and 2008 to 2011. The high productivity of articles during these years may be due to their significance in cancer biology literature, having received prominence in research. Conclusion: There is an obvious need for better compilations of statistics on numbers of publications in the years from 2000 to 2011 on various disciplines on a worldwide scale, for informed critical assessments of the amount of new knowledge contributed by these publications, and for enhancements and refinements of present Scientometric techniques (citation and publication counts, so that valid measures of knowledge growth may be obtained. Only then will Scientometrics be able to provide accurate, useful descriptions and predictions of knowledge growth.

  18. Redes En Acción. Increasing Hispanic participation in cancer research, training, and awareness.

    Science.gov (United States)

    Ramirez, Amelie G; Talavera, Gregory A; Marti, Jose; Penedo, Frank J; Medrano, Martha A; Giachello, Aida L; Pérez-Stable, Eliseo J

    2006-10-15

    Hispanics are affected by many health care disparities. The National Cancer Institute (NCI), through its Special Populations Branch, is supporting networking and capacity-building activities designed to increase Hispanic participation and leadership in cancer research. Redes En Acción established a national network of cancer research centers, community-based organizations, and federal partners to facilitate opportunities for junior Hispanic scientists to participate in training and research projects on cancer control. Since 2000, Redes En Acción has established a network of more than 1800 Hispanic leaders involved in cancer research and education. The project has sustained 131 training positions and submitted 29 pilot projects to NCI for review, with 16 awards for a total of $800,000, plus an additional $8.8 million in competing grant funding based on pilot study results to date. Independent research has leveraged an additional $32 million in non-Redes funding, and together the national and regional network sites have participated in more than 1400 community and professional awareness events. In addition, the program conducted extensive national survey research that provided the basis for the Redes En Acción Latino Cancer Report, a national agenda on Hispanic cancer issues. Redes En Acción has increased participation in cancer control research, training, and awareness among Hispanic scientists and within Hispanic communities. Cancer 2006. (c) 2006 American Cancer Society. PMID:16958026

  19. Recent translational research: computational studies of breast cancer.

    Science.gov (United States)

    Retsky, Michael; Demicheli, Romano; Hrushesky, William; Speer, John; Swartzendruber, Douglas; Wardwell, Robert

    2005-01-01

    The combination of mathematics--queen of sciences--and the general utility of computers has been used to make important inroads into insight-providing breast cancer research and clinical aids. These developments are in two broad areas. First, they provide useful prognostic guidelines for individual patients based on historic evidence. Second, by suggesting numeric tumor growth laws that are correlated to clinical parameters, they permit development of biologically relevant theories and comparison with patient data to help us understand complex biologic processes. These latter studies have produced many new ideas that are testable in clinical trials. In this review we discuss these developments from a clinical perspective, and ask whether and how they translate into useful tools for patient treatment. PMID:15642181

  20. Psychological research and the prostate-cancer screening controversy.

    Science.gov (United States)

    Arkes, Hal R; Gaissmaier, Wolfgang

    2012-06-01

    In October of 2011, the U.S. Preventive Services Task Force released a draft report in which they recommended against using the prostate-specific antigen (PSA) test to screen for prostate cancer. We attempt to show that four factors documented by psychological research can help explain the furor that followed the release of the task force's report. These factors are the persuasive power of anecdotal (as opposed to statistical) evidence, the influence of personal experience, the improper evaluation of data, and the influence of low base rates on the efficacy of screening tests. We suggest that augmenting statistics with facts boxes or pictographs might help such committees communicate more effectively with the public and with the U.S. Congress. PMID:22555966

  1. Annotated English

    CERN Document Server

    Hernandez-Orallo, Jose

    2010-01-01

    This document presents Annotated English, a system of diacritical symbols which turns English pronunciation into a precise and unambiguous process. The annotations are defined and located in such a way that the original English text is not altered (not even a letter), thus allowing for a consistent reading and learning of the English language with and without annotations. The annotations are based on a set of general rules that make the frequency of annotations not dramatically high. This makes the reader easily associate annotations with exceptions, and makes it possible to shape, internalise and consolidate some rules for the English language which otherwise are weakened by the enormous amount of exceptions in English pronunciation. The advantages of this annotation system are manifold. Any existing text can be annotated without a significant increase in size. This means that we can get an annotated version of any document or book with the same number of pages and fontsize. Since no letter is affected, the ...

  2. Every teacher an English teacher? Literacy strategy teaching and research in the content area of science education

    Science.gov (United States)

    Buckingham, Thomas

    Recent statements from teachers of English and literacy (NCTE, 2007) have voiced the failure of schools to help minority students and ELLs close the literacy achievement gap and the responsibility of all teachers to help with this endeavor. Central to this effort in secondary schools are the content area teachers, as their subjects constitute the bulk of school day instruction. While there have been small studies and field reports of what content teachers are or are not teaching in the way of literacy instruction (Fisher and Ivey, 2005; Verplaste, 1996, 1998; Vacca and Vacca 1989), researchers have not had success measuring the literacy practices of content area teachers in a broad-based study. This study focuses specifically on what many researchers in both the content literacy and ESL fields have emphasized for promoting literacy in the classroom---teaching metacognitive strategies. Twelve metacognitive functions derived from a literacy strategies handbook are employed as a means to ascertain strategy usage within the lessons whether specifically known content strategies are named or not. The initial analysis is performed on over 100 lesson plans hosted at four prominent university science education sites, all within a five year period (2003-7). In addition to the lesson plan analysis, a review of 100 articles taken from five on-line science education journals reveal what the science education field addresses this issue. Findings suggest that while 80% of science teachers include some type of strategic teaching and learning in their lessons, only about 20% of science teachers explicitly utilize strategies as listed in content literacy manuals and promoted by literacy and ESL experts. Rather, most science teachers implicitly include these strategies within their lessons and/or promote their own subject-specific strategies in content teaching. Analysis of science education research and publications shows that there is a focus on literacy and specifically strategic

  3. Investigation of English Writing Strategies of English Major Students at Ji'an Normal School

    Institute of Scientific and Technical Information of China (English)

    龚萌

    2014-01-01

    With the development and growth of the English teaching methodology,more and more researchers and experts have started to focus on English writing,and more and more people concentrate on English writing and how to improve English writing ability.

  4. Investigation of English Writing Strategies of English Major Students at Ji’an Normal School

    Institute of Scientific and Technical Information of China (English)

    龚萌

    2014-01-01

    With the development and growth of the English teaching methodology,more and more researchers and experts have started to focus on English writing,and more and more people concentrate on English writing and how to improve English writing ability.

  5. Epidemiology of breast cancer at the shaukat khanum memorial cancer hospital and research center, lahore, pakistan

    International Nuclear Information System (INIS)

    To describe the demographic and clinical features of females presenting with breast malignancies at the Shaukat Khanum Memorial Cancer Hospital and Research Center (SKMCH and RC), Lahore, Pakistan. Study Design: An observational study. Place and Duration of Study: SKMCH and RC, Lahore, from January 2008 to December 2012. Methodology: Demographic and clinical features of female breast cancer patients, registered at SKMCH and RC, were studied. Mean values, counts, and percentages were obtained. Results: Four-thousand, three-hundred and sixty-six female breast malignancies were recorded. Nearly 80.4% of the patients belonged to Punjab. Mean age at presentation was 48.6 ± 12.2 years, at menarche was 13.2 ± 1.2 years, and at first childbirth was 23.7 ± 4.8 years. Mean Body Mass Index (BMI) was 29.0 ± 5.7 kg/m2. In 60.1%, history of breast feeding was positive. In 55.7%, there was no history of use of any Oral Contraceptive Pills (OCP)/Hormone Replacement Therapy (HRT). Nearly 42.7% were postmenopausal, 85.2% had infiltrating ductal carcinoma, 49.6% had grade 3 tumor, 60.7% had stage II disease, and 37.3% were Estrogen Receptor (ER)/Progesterone Receptor (PR)+, Human Epidermal Growth Factor Receptor 2 (HER2)-. Family history of breast cancer was positive in 16.9% of the cases. Conclusion: The mean presenting age is lower than what has been recorded in the West. It may be worthwhile collating results from different institutions in order to study the epidemiology of the disease more extensively and develop cancer control and early detection programs. (author)

  6. Symptoms of Ovarian Cancer

    Science.gov (United States)

    ... Informed Cancer Home What Are the Symptoms of Ovarian Cancer? Language: English Español (Spanish) Recommend on Facebook Tweet Share Compartir Gynecologic cancer symptoms diaries Ovarian cancer may cause one or more of these ...

  7. The Utilization and Limitation of CD133 Epitopes in Lung Cancer Stem Cells Research

    Directory of Open Access Journals (Sweden)

    Yin CHEN

    2011-10-01

    Full Text Available Lung cancer is one of the most common tumor, which lacks of effective clinical treatment to lead to desirable prognosis. According to cancer stem cell hypothesis, lung cancer stem cells are considered to be responsible for carcinogenesis, development, metastasis, recurrence, invasion, resistance to chemotherapy and radiotherapy of lung cancer. In recent years, more and more institutes used glycosylated CD133 epitopes to define, isolate, purify lung cancer stem cells. However, along with deeply research, the application of CD133 epitopes in lung cancer stem cell research is questioned. The utilization and limitation of CD133 epitopes in lung cancer stem cells research for the past few years is summaried in this review.

  8. English Intonation Study on Male English Majors

    Institute of Scientific and Technical Information of China (English)

    邹维康

    2015-01-01

    <正>1.Overview of English Intonation Research Intonation is the melody of speech.Pitch changes on stressed syllables determine the intonation patterns of an utterance.Intonation is the combination of pitch variations and stress.Intonation is also interpreted by Halliday as a complex of three systemic variables,tonality,tonicity and tone.According

  9. Building a Long Distance Training Program to Enhance Clinical Cancer Research Capacity in Puerto Rico

    OpenAIRE

    Appleyard, Caroline B.; Antonia, Scott J; Daniel M. Sullivan; Santiago-Cardona, Pedro G.; Cáceres, William; Velez, Hector; Torres-Ruiz, Jose A.; Wright, Kenneth L.

    2015-01-01

    Barriers persist in the development and delivery of effective cancer therapies to under-represented minority populations. In Puerto Rico, cancer is the second leading cause of death, yet cancer research awareness and training opportunities remain somewhat limited on the island. These limitations hinder progress toward decreasing the cancer health disparities that exist within the Puerto Rican population. The predominantly Hispanic population of Puerto Rico is the focus of a partnership betwee...

  10. 内容本位的高职专业与基础英语融合实证研究--以物流管理专业为例%Content-based Empirical Research of Integration of Professional English and Basic English in Higher Vocational Colleges:A Case Study in Logistics Management

    Institute of Scientific and Technical Information of China (English)

    岳华

    2014-01-01

    就高职专业英语与基础英语融合不够,所培养学生专业英语掌握不够现状,青岛职业技术学院开展了内容本位的高职专业英语与基础英语融合研究,即有意识地融入一些相关专业英语教学内容活动模块,引导学生及早接触和学习与所修专业有关的专业内容。研究结果表明,进行内容本位的专业英语与基础英语融合教学改革行之有效,教改不但没有影响教改班学生的基础英语成绩,还对提升教改班学生职业素养和技能,缩短学校所学与企业所需间差距有所帮助。%To address the insufficient integration of professional English and basic English and insufficient command of professional English, Qingdao Technical College launched content-based empirical research of professional English and basic English. That is to add consciously a number of related professional English related to the students' major in their basic English, guiding students to know and learn more their major as early as possible. The research results show that the teaching reform of integration of professional English and basic English in vocational colleges worked well. The reform does not only affect the reform-class students' basic English performance, but also enhance their professionalism and skills, shorten the gap between what to study in colleges and what is needed in enterprises.

  11. What's New in Stomach Cancer Research and Treatment?

    Science.gov (United States)

    ... Local Offices Volunteer Employment Become a Supplier Report Fraud or ... reserved. The American Cancer Society is a qualified 501(c)(3) tax-exempt organization. Cancer.org is provided courtesy of ...

  12. Director's Update - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (NCI-CPTAC) has recently begun the proteomic interrogation of genomically-characterized tumors from The Cancer Genome Atlas.

  13. Clinical Assay Development Support - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The NCI’s Division of Cancer Treatment and Diagnosis and the Cancer Diagnosis Program announce a request for applications for the Clinical Assay Development Program (CADP) for investigators seeking clinical assay development and validation resources.

  14. Recent Progress on Nutraceutical Research in Prostate Cancer

    OpenAIRE

    Li, Yiwei; Ahmad, Aamir; Kong, Dejuan; Bao, Bin; Sarkar, Fazlul H.

    2014-01-01

    Recently, nutraceuticals have received increasing attention as the agents for cancer prevention and supplement with conventional therapy. Prostate Cancer (PCa) is most frequently diagnosed cancer and second leading cause of cancer-related death in men in US. Growing evidences from epidemiological studies, in vitro experimental studies, animal studies, and clinical trials have shown that nutraceuticals could be very useful for the prevention and treatment of PCa. Several nutraceuticals includi...

  15. What's New in Research and Treatment of Melanoma Skin Cancer?

    Science.gov (United States)

    ... number of skin cancers and the pain and loss of life from this disease is to educate the public, ... Blog Programs & Services Breast Cancer Support TLC Hair Loss & Mastectomy ... Cancer Relay For Life Events College Relay For Life Relay Recess Donate ...

  16. Computational Omics - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC) and the NVIDIA Foundation are pleased to announce funding opportunities in the fight against cancer. Each organization has launched a request for proposals (RFP) that will collectively fund up to $2 million to help to develop a new generation of data-intensive scientific tools to find new ways to treat cancer.

  17. Call for a Computer-Aided Cancer Detection and Classification Research Initiative in Oman.

    Science.gov (United States)

    Mirzal, Andri; Chaudhry, Shafique Ahmad

    2016-01-01

    Cancer is a major health problem in Oman. It is reported that cancer incidence in Oman is the second highest after Saudi Arabia among Gulf Cooperation Council countries. Based on GLOBOCAN estimates, Oman is predicted to face an almost two-fold increase in cancer incidence in the period 2008-2020. However, cancer research in Oman is still in its infancy. This is due to the fact that medical institutions and infrastructure that play central roles in data collection and analysis are relatively new developments in Oman. We believe the country requires an organized plan and efforts to promote local cancer research. In this paper, we discuss current research progress in cancer diagnosis using machine learning techniques to optimize computer aided cancer detection and classification (CAD). We specifically discuss CAD using two major medical data, i.e., medical imaging and microarray gene expression profiling, because medical imaging like mammography, MRI, and PET have been widely used in Oman for assisting radiologists in early cancer diagnosis and microarray data have been proven to be a reliable source for differential diagnosis. We also discuss future cancer research directions and benefits to Oman economy for entering the cancer research and treatment business as it is a multi-billion dollar industry worldwide. PMID:27268600

  18. Guidelines for the welfare and use of animals in cancer research

    OpenAIRE

    Workman, P; Aboagye, E O; Balkwill, F; Balmain, A; Bruder, G; Chaplin, D. J.; Double, J A; Everitt, J; Farningham, D A H; Glennie, M. J.; Kelland, L R; Robinson, V.; Stratford, I J; Tozer, G. M.; Watson, S.

    2010-01-01

    Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on the welfare and use of animals in cancer research. All experiments should incorporate the 3Rs: replacement, reduction and refinement. Focusing on animal welfare, we present recomme...

  19. DCP's Early Detection Research Guides Future Science | Division of Cancer Prevention

    Science.gov (United States)

    Early detection research funded by the NCI's Division of Cancer Prevention has positively steered both public health and clinical outcomes, and set the stage for findings in the next generation of research. |

  20. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Role in Cancer Research Intramural Research Extramural Research Bioinformatics and Cancer NCI-Designated Cancer Centers Frederick National ... Role in Cancer Research Intramural Research Extramural Research Bioinformatics and Cancer NCI-Designated Cancer Centers Frederick National ...

  1. Employment and the common cancers: return to work of cancer survivors

    NARCIS (Netherlands)

    A.G.E.M. de Boer; M.H.W. Frings-Dresen

    2009-01-01

    Aims To provide an overview of the outcomes of recent European research in this field and discusses future research directions to explore and improve the return-to-work experience of cancer survivors. Methods European research, principally from English and Dutch language journals, on the subject of

  2. SPECIAL ENGLISH.

    Science.gov (United States)

    English Language Services, Inc., Washington, DC.

    THIS 14-VOLUME SERIES OF TECHNICAL ENGLISH TEXTS IS DESIGNED TO PROVIDE PRACTICE IN TECHNICAL TERMINOLOGY FOR NON-NATIVE SPEAKERS OF ENGLISH. LANGUAGE FLUENCY LEVEL IS UPPER-INTERMEDIATE/ADVANCED. THE VARIOUS FIELDS OF INDUSTRY WHICH THE TEXTS DEAL WITH ARE AS FOLLOWS--(1) AGRICULTURE--BOOK 1, SOILS (2) AGRICULTURE--BOOK 2, FIELD CROPS (3)…

  3. CALL English

    DEFF Research Database (Denmark)

    Barlach, Else

    This multimedia program of English grammar caters specifically for Danish students at Bachelor level. The handbook introduces students to well-established grammatical terminology within the traditional areas of English grammar, and the CD-ROM, which contains about 120 exercises, offers students a...

  4. Maori English

    Science.gov (United States)

    Maclagan, Margaret; King, Jeanette; Gillon, Gail

    2008-01-01

    The Maori language is the language of the indigenous people of New Zealand. Today, not all Maori speak the Maori language, and many Maori as well as non-Maori speak Maori English, the fastest growing of the main varieties of New Zealand English. This paper provides a background to the linguistic situation of the Maori populace in New Zealand,…

  5. Up from Under: English Training on the Mines. Report on 1988 Research Project Conducted at Gold Fields Training Services.

    Science.gov (United States)

    Puhl, Carol A.

    A South African project investigated effective methods of English language instruction for educationally disadvantaged black gold mine workers. Four instructors taught eight 3-week intensive classes, four by traditional language teaching methods and four by methods used at the Institute for Language Teaching of the University of Stellenbosch…

  6. Research on Application of Metacognitive Strategy in English Listening in the Web-based Self-access Learning Environment

    Institute of Scientific and Technical Information of China (English)

    罗雅清

    2012-01-01

      Metacognitive strategies are regarded as advanced strategies in all the learning strategies. This study focuses on the ap⁃plication of metacognitive strategies in English listening in the web-based self-access learning environment (WSLE) and tries to provide some references for those students and teachers in the vocational colleges.

  7. Growing Capacity with the Vocabulary of English Language Arts Programs: Vocabulary Megaclusters. Reading Research Report. #11.02

    Science.gov (United States)

    Hiebert, Elfrieda H.

    2011-01-01

    The typical approach to teaching vocabulary in English/Language Arts programs has been to focus on six to eight words per text. Even though these words may add meaning to a particular story, the target words are often rare and their generalizability is limited. The Vocabulary Megaclusters provides a framework for selecting and teaching words…

  8. Practical Research on Secondary Vocational English Tea-ching%中职英语教学实用性研究

    Institute of Scientific and Technical Information of China (English)

    安琪

    2014-01-01

    本文对中职英语教学单纯英语教学向实用性转变的教学改革进行研究,在中等职业学校实施双语教学是实用性英语教学的一种重要方式,运用英语进行双语教学,在教学管理和实践教学等多层面进行分析,针对在中等职业教育中开展这种实用性教学存在的现实问题,提出解决方案和途径,为中职英语教学实用性教学改革的转变提供依据。%This paper studied the teaching reform of transforming the pure teaching to practical teaching in secondary vocational English teaching. To carry out bilingual teaching in secondary vocational schools is an important way of practical English teach-ing. This paper uses English as a means of bilingual teaching and analyzes the teaching management and practice teaching, and based on the problems existing in the practical teaching of sec-ondary vocational education, proposes relevant solutions , aiming to provide references for the practical teaching reform and trans-formation of secondary vocational English teaching.

  9. Recommendations for Cancer Epidemiologic Research in Understudied Populations and Implications for Future Needs.

    Science.gov (United States)

    Martin, Damali N; Lam, Tram Kim; Brignole, Katy; Ashing, Kimlin T; Blot, William J; Burhansstipanov, Linda; Chen, Jarvis T; Dignan, Mark; Gomez, Scarlett Lin; Martinez, Maria Elena; Matthews, Alicia; Palmer, Julie R; Perez-Stable, Eliseo J; Schootman, Mario; Vilchis, Hugo; Vu, Alexander; Srinivasan, Shobha

    2016-04-01

    Medically underserved populations in the United States continue to experience higher cancer burdens of incidence, mortality, and other cancer-related outcomes. It is imperative to understand how health inequities experienced by diverse population groups may contribute to our increasing unequal cancer burdens and disparate outcomes. The National Cancer Institute convened a diverse group of scientists to discuss research challenges and opportunities for cancer epidemiology in medically underserved and understudied populations. This report summarizes salient issues and discusses five recommendations from the group, including the next steps required to better examine and address cancer burden in the United States among our rapidly increasing diverse and understudied populations. Cancer Epidemiol Biomarkers Prev; 25(4); 573-80. ©2016 AACR SEE ALL ARTICLES IN THIS CEBP FOCUS SECTION, "MULTILEVEL APPROACHES TO ADDRESSING CANCER HEALTH DISPARITIES". PMID:27196089

  10. Cancer Patient and Survivor Research from the Cancer Information Service Research Consortium: A Preview of Three Large Randomized Trials and Initial Lessons Learned

    Science.gov (United States)

    MARCUS, ALFRED C.; DIEFENBACH, MICHAEL A.; STANTON, ANNETTE L.; MILLER-HALEGOUA, SUZANNE N.; FLEISHER, LINDA; RAICH, PETER C.; MORRA, MARION E.; PEROCCHIA, ROSEMARIE SLEVIN; TRAN, ZUNG VU; BRIGHT, MARY ANNE

    2014-01-01

    Three large randomized trials are described from the Cancer Information Service Research Consortium (CISRC). Three web-based multimedia programs are being tested to help newly diagnosed prostate (Project 1) and breast cancer patients (Project 2) make informed treatment decisions and breast cancer patients prepare for life after treatment (Project 3). Project 3 is also testing a telephone callback intervention delivered by a cancer information specialist. All participants receive standard print material specific to each project. Preliminary results from the two-month follow-up interviews are reported for the initial wave of enrolled participants, most of whom were recruited from the Cancer Information Service (1-800-4-CANCER) telephone information program (Project 1 = 208, Project 2 = 340, Project 3 = 792). Self-reported use of the multimedia program was 51%, 52% and 67% for Projects 1–3, respectively. Self-reported use of the print materials (read all, most or some) was 90%, 85% and 83% for Projects 1–3, respectively. The callback intervention was completed by 92% of Project 3 participants. Among those using the CISRC interventions, perceived utility and benefit was high, and more than 90% would recommend them to other cancer patients. Five initial lessons learned are presented that may help inform future cancer communications research. PMID:23448232

  11. The Cervix Cancer Research Network (CCRN: Increasing access to cancer clinical trials in low- and middle-income countries

    Directory of Open Access Journals (Sweden)

    Gita eSuneja

    2015-02-01

    Full Text Available Introduction: The burden of cervical cancer is large and growing in developing countries, due in large part to limited access to screening services and lack of human papillomavirus (HPV vaccination. In spite of modern advances in diagnostic and therapeutic modalities, outcomes from cervical cancer have not markedly improved in recent years. Novel clinical trials are urgently needed to improve outcomes from cervical cancer worldwide. Methods: The Cervix Cancer Research Network (CCRN, a subsidiary of the Gynecologic Cancer InterGroup (GCIG, is a multi-national, multi-institutional consortium of physicians and scientists focused on improving cervical cancer outcomes worldwide by making cancer clinical trials available in low-, middle-, and high-income countries. Standard operating procedures for participation in CCRN include a pre-qualifying questionnaire to evaluate clinical activities and research infrastructure, followed by a site visit. Once a site is approved, they may choose to participate in one of four currently accruing clinical trials.Results: To date, 13 different CCRN site visits have been performed. Of these 13 sites visited, 10 have been approved as CCRN sites including Tata Memorial Hospital, India; Bangalore, India; Trivandrum, India; Ramathibodi, Thailand; Siriaj, Thailand; Pramongkutklao, Thailand; Ho Chi Minh, Vietnam; Blokhin Russian Cancer Research Center; the Hertzen Moscow Cancer Research Institute; and the Russian Scientific Center of Roentgenoradiology. The four currently accruing clinical trials are TACO, OUTBACK, INTERLACE, and SHAPE.Discussion: The CCRN has successfully enrolled 10 sites in developing countries to participate in four randomized clinical trials. The primary objectives are to provide novel therapeutics to regions with the greatest need and to improve the validity and generalizability of clinical trial results by enrolling a diverse sample of patients.

  12. Development and Pilot Evaluation of Native CREST – a Cancer Research Experience and Student Training Program for Navajo Undergraduate Students

    OpenAIRE

    Hughes, Christine A; Bauer, Mark C.; Horazdovsky, Bruce F.; Garrison, Edward R.; Patten, Christi A.; Petersen, Wesley O.; Bowman, Clarissa N.; Vierkant, Robert A.

    2013-01-01

    The Mayo Clinic Cancer Center and Diné College received funding for a 4-year collaborative P20 planning grant from the National Cancer Institute in 2006. The goal of the partnership was to increase Navajo undergraduates’ interest in and commitment to biomedical coursework and careers, especially in cancer research. This paper describes the development, pilot testing and evaluation of Native CREST (Cancer Research Experience & Student Training), a 10-week cancer research training program provi...

  13. World Englishes and English Learning in China

    Institute of Scientific and Technical Information of China (English)

    GONG Ting

    2015-01-01

    The global spread of English is remarkable, for it has developed many different non-native varieties of English (“world Englishes”). On account of the varieties of English, the essay reviews briefly historical causes and relevant literature for English globalization. The issues of English localization, who is qualified as English instructor, what kind of English to learn and how is English changing in China are included. The essay discusses also the implications of World Englishes for English language learning and proposes three points in the context of learning English in China:(1) English language learning should take into account the changes of English;(2)attitude towards global and local English variants should be properly treated;(3)compared with English test results, more attention must be paid to practical communication competences.

  14. [Cancer].

    Science.gov (United States)

    de la Peña-López, Roberto; Remolina-Bonilla, Yuly Andrea

    2016-09-01

    Cancer is a group of diseases which represents a significant public health problem in Mexico and worldwide. In Mexico neoplasms are the second leading cause of death. An increased morbidity and mortality are expected in the next decades. Several preventable risk factors for cancer development have been identified, the most relevant including tobacco use, which accounts for 30% of the cancer cases; and obesity, associated to another 30%. These factors, in turn, are related to sedentarism, alcohol abuse and imbalanced diets. Some agents are well knokn to cause cancer such as ionizing radiation, viruses such as the papilloma virus (HPV) and hepatitis virus (B and C), and more recently environmental pollution exposure and red meat consumption have been pointed out as carcinogens by the International Agency for Research in Cancer (IARC). The scientific evidence currently available is insufficient to consider milk either as a risk factor or protective factor against different types of cancer. PMID:27603890

  15. Recruiting Chinese- and Korean-Americans in Cancer Survivorship Research: Challenges and Lessons Learned.

    Science.gov (United States)

    Lim, Jung-Won; Paek, Min-So

    2016-03-01

    This paper describes Asian-American recruitment experiences using data from the cancer survivorship study involving Chinese- and Korean-American breast cancer survivors specifically. The article discusses challenges to the successful recruitment of Asian-American populations for cancer survivorship research and provides recommendations for future recruitment efforts. The study investigated the role of family communication in coping and quality of life for survivors from Chinese- and Korean-American groups diagnosed with breast cancer. Participants were primarily recruited through cancer registries and community outreach. A total of 157 breast cancer survivors (86 Chinese-Americans and 71 Korean-Americans) completed the final survey, yielding a final response rate of 62.8 % of the accessible samples. Chinese-Americans were more likely to agree to participate but less frequently completed the survey, and Korean-Americans were more likely to refuse to participate. Common reasons for refusal were "too busy or too painful to recall," followed by "not interested," "too old," "distrust of the research," or "health issue." Participants were more likely to be young and Korean-American compared to non-participants. Cultural and linguistic barriers, distrust, and lack of awareness about cancer research should be considered to recruit more Asian-American cancer survivors. Community participatory research is required to ensure participation by sufficient numbers of ethnic minorities in cancer survivorship research. PMID:25619194

  16. Moving forward in colorectal cancer research, what proteomics has to tell

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Colorectal cancer is the third most common cancer and is highly fatal. During the last several years, research has been primarily based on the study of expression profiles using microarray technology. But now, investigators are putting into practice proteomic analyses of cancer tissues and cells to identify new diagnostic or therapeutic biomarkers for this cancer. Because the proteome reflects the state of a cell, tissue or organism more accurately, much is expected from proteomics to yield better tumor markers for disease diagnosis and therapy monitoring. This review summarizes the most relevant applications of proteomics the biomarker discovery for colorectal cancer.

  17. Mental health of patients with lung cancer

    OpenAIRE

    Τogas Κ.; Alexias G.

    2016-01-01

    Background: Lung cancer is a very common type of cancer. The psychological reactions of these patients haven't been studied yet. Aim: The examination of the mental health of lung cancer patients. Methods: A bibliographical review of relevant articles was conducted at the electronic data bases of Pubmed, Pcych Info and Scholar Google by key-words. The quest included researches and reviews which have been published in Greek and English language between 1990- 2013. Results: Lung canc...

  18. An Introduction to English Teaching, A Textbook for English Educators

    Science.gov (United States)

    Lin, Grace Hui Chin; Chien, Paul Shih-chieh

    2010-01-01

    Teaching English became a professional and academic field from a half century ago. Many researches for teacher education and teacher training have been conducted in order to raise the English as well as the foreign language trainers' knowledge and capabilities in carrying out effective lessons in classroom. During second millennium of speedily…

  19. A Research on English Reading Difficulties of Non- English Majors of Capital Normal University%首都师范大学非英语专业大学生英语阅读困难的研究

    Institute of Scientific and Technical Information of China (English)

    赵彦林

    2012-01-01

    This study aims to explore English reading difficulties of non - English majors in the first and second year of Capital Normal University. Participants in this study are 502 students of the first and second year. Research instru- ment is questionnaire investigation. Data obtained from the questionnaire investigation is analyzed with SPSS17.0 statistical software. Research results shows: ( t ) The non - English majors have intermediate difficulties in vocabulary, grammar, discourse and thinking. By comparison, they have greater difficulty in vocabulary and grammar. (2) There almost exists significant difference in between any two groups among higher, intermediate and lower achiever groups in the aspect of vo- cabulary, grammar, discourse and thinking. There exists almost no significant difference between literal arts students and science students, nor between male and female students.%本研究旨在考察首都师范大学一、二年级非英语专业学生的英语阅读困难。研究参与者为502名大学生,研究工具为调查问卷,用SPSS17.0软件对问卷得出的数据进行统计分析,得出:(1)此高校非英语专业的学生在英语阅读中,在词汇、语法、语篇和思维方面都具有中等程度的困难,相比之下,在词汇和语法方面的困难更大一些。(2)大一、大二的学生按高考入学分数分为高、中、低三组,其中任意两组在词汇、语法、语篇和认知思维方面几乎都存在显著差异,按文理科学生分组和按男女分组,基本没有显著差异。

  20. Biospecimen Solicitation - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    A funding opportunity in support of the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) seeks to prospectively procure tumor samples, collected for proteomics investigation.

  1. Bioengineered models of solid human tumors for cancer research

    Science.gov (United States)

    Marturano-Kruik, Alessandro; Villasante, Aranzazu; Vunjak-Novakovic, Gordana

    2016-01-01

    Summary The lack of controllable in vitro models that can recapitulate the features of solid tumors such as Ewing’s sarcoma limits our understanding of the tumor initiation and progression and impedes the development of new therapies. Cancer research still relies of the use of simple cell culture, tumor spheroids, and small animals. Tissue-engineered tumor models are now being grown in vitro to mimic the actual tumors in patients. Recently, we have established a new protocol for bioengineering the Ewing’s sarcoma, by infusing tumor cell aggregates into the human bone engineered from the patient’s mesenchymal stem cells. The bone niche allows crosstalk between the tumor cells, osteoblasts and supporting cells of the bone, extracellular matrix and the tissue microenvironment. The bioreactor platform used in these experiments also allows the implementation of physiologically relevant mechanical signals. Here, we describe a method to build an in vitro model of Ewing’s sarcoma that mimics the key properties of the native tumor and provides the tissue context and physical regulatory signals. PMID:27115504

  2. Meaning and the English verb

    CERN Document Server

    Leech, Geoffrey

    2014-01-01

    Every language has its peculiar problems of meaning for the foreign learner. In the English language, some of the biggest yet most fascinating problems are concentrated in the area of the finite verb phrase: in particular, tense, aspect, mood and modality. Meaning and the English Verb describes these fields in detail for teachers and advanced students of English as a foreign or second language. This new third edition uses up-to-date examples to show differences and similarities between American and British english, reflecting a great deal of recent research in this area. It also takes account

  3. Cancer Research Center Indiana University School of Medicine

    International Nuclear Information System (INIS)

    The Department of Energy (DOE) proposes to authorize the Indiana School of Medicine to proceed with the detailed design, construction and equipping of the proposed Cancer Research Center (CRC). A grant was executed with the University on April 21, 1992. A four-story building with basement would be constructed on the proposed site over a 24-month period. The proposed project would bring together, in one building, three existing hematology/oncology basic research programs, with improved cost-effectiveness through the sharing of common resources. The proposed site is currently covered with asphaltic pavement and is used as a campus parking lot. The surrounding area is developed campus, characterized by buildings, walkways, with minimal lawns and plantings. The proposed site has no history of prior structures and no evidence of potential sources of prior contamination of the soil. Environmental impacts of construction would be limited to minor increases in traffic, and the typical noises associated with standard building construction. The proposed CRC project operation would involve the use radionuclides and various hazardous materials in conducting clinical studies. Storage, removal and disposal of hazardous wastes would be managed under existing University programs that comply with federal and state requirements. Radiological safety programs would be governed by Nuclear Regulatory Commission (NRC) license and applicable Environmental Protection Agency (EPA) regulations. There are no other NEPA reviews currently active which are in relationship to this proposed site. The proposed project is part of a Medical Campus master plan and is consistent with applicable local zoning and land use requirements

  4. Cancer Research Center Indiana University School of Medicine

    Energy Technology Data Exchange (ETDEWEB)

    1994-08-01

    The Department of Energy (DOE) proposes to authorize the Indiana School of Medicine to proceed with the detailed design, construction and equipping of the proposed Cancer Research Center (CRC). A grant was executed with the University on April 21, 1992. A four-story building with basement would be constructed on the proposed site over a 24-month period. The proposed project would bring together, in one building, three existing hematology/oncology basic research programs, with improved cost-effectiveness through the sharing of common resources. The proposed site is currently covered with asphaltic pavement and is used as a campus parking lot. The surrounding area is developed campus, characterized by buildings, walkways, with minimal lawns and plantings. The proposed site has no history of prior structures and no evidence of potential sources of prior contamination of the soil. Environmental impacts of construction would be limited to minor increases in traffic, and the typical noises associated with standard building construction. The proposed CRC project operation would involve the use radionuclides and various hazardous materials in conducting clinical studies. Storage, removal and disposal of hazardous wastes would be managed under existing University programs that comply with federal and state requirements. Radiological safety programs would be governed by Nuclear Regulatory Commission (NRC) license and applicable Environmental Protection Agency (EPA) regulations. There are no other NEPA reviews currently active which are in relationship to this proposed site. The proposed project is part of a Medical Campus master plan and is consistent with applicable local zoning and land use requirements.

  5. Cancer Research UK Centre for Drug Development: translating 21st-century science into the cancer medicines of tomorrow.

    Science.gov (United States)

    Ritchie, James W A; Williams, Robert J

    2015-08-01

    The Cancer Research UK Centre (CRUK) for Drug Development (CDD) can trace its origins back to the Cancer Research Campaign Phase I/II Committee (created in 1980) and to date has tested over 120 potential cancer medicines in early-phase clinical trials. Five drugs are now registered, providing benefit to thousands of patients with cancer as part of their routine standard of care. In recent years, the CDD has established several different business and operating models that provide it with access to the pipelines of pharmaceutical and biotechnology companies. This has enabled potential new treatments to be taken into clinical development that might have otherwise languished on companies' shelves and has increased the number of drug combinations being explored in early-phase clinical trials. PMID:25794601

  6. Professional Memory and English Teaching

    Science.gov (United States)

    Tarpey, Paul

    2009-01-01

    This article concerns the way that research into Professional Memory (PM) in English teaching might re-connect the school subject with constituencies--the individuals, communities and social values--it once served. By PM I mean the collective memories of a generation of English teachers which, when brought into conjunction with existing histories,…

  7. The English Tower of Babel

    Institute of Scientific and Technical Information of China (English)

    VALERIE; SARTOR

    2009-01-01

    English is clearly the lingua franca of today’s modern world. This lan- guage began international service in science and research, civil aviation and postal services after the end of World War II. Today, via the information superhighway powered by the Internet and other communication technologies, English impacts everyone on the planet China is no exception.

  8. A breast cancer clinical registry in an Italian comprehensive cancer center: an instrument for descriptive, clinical, and experimental research.

    Science.gov (United States)

    Baili, Paolo; Torresani, Michele; Agresti, Roberto; Rosito, Giuseppe; Daidone, Maria Grazia; Veneroni, Silvia; Cavallo, Ilaria; Funaro, Francesco; Giunco, Marco; Turco, Alberto; Amash, Hade; Scavo, Antonio; Minicozzi, Pamela; Bella, Francesca; Meneghini, Elisabetta; Sant, Milena

    2015-01-01

    In clinical research, many potentially useful variables are available via the routine activity of cancer center-based clinical registries (CCCR). We present the experience of the breast cancer clinical registry at Fondazione IRCCS "Istituto Nazionale dei Tumori" to give an example of how a CCCR can be planned, implemented, and used. Five criteria were taken into consideration while planning our CCCR: (a) available clinical and administrative databases ought to be exploited to the maximum extent; (b) open source software should be used; (c) a Web-based interface must be designed; (d) CCCR data must be compatible with population-based cancer registry data; (e) CCCR must be an open system, able to be connected with other data repositories. The amount of work needed for the implementation of a CCCR is inversely linked with the amount of available coded data: the fewer data are available in the input databases as coded variables, the more work will be necessary, for information technology staff, text mining analysis, and registrars (for collecting data from clinical records). A cancer registry in a comprehensive cancer center can be used for several research aspects, such as estimate of the number of cases needed for clinical studies, assessment of biobank specimens with specific characteristics, evaluation of clinical practice and adhesion to clinical guidelines, comparative studies between clinical and population sets of patients, studies on cancer prognosis, and studies on cancer survivorship. PMID:25953447

  9. Open-Access Cancer Genomics - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The completion of the Human Genome Project sparked a revolution in high-throughput genomics applied towards deciphering genetically complex diseases, like cancer. Now, almost 10 years later, we have a mountain of genomics data on many different cancer type

  10. CPTAC Releases Largest-Ever Breast Cancer Proteome Dataset - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    National Cancer Institute (NCI) Clinical Proteomic Tumor Analysis Consortium (CPTAC) scientists have released a dataset of proteins and phophorylated phosphopeptides identified through deep proteomic and phosphoproteomic analysis of breast tumor samples, previously genomically analyzed by The Cancer Genome Atlas (TCGA).

  11. Breast Cancer Proteomic and Phosphoproteomic Data Released - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    National Cancer Institute (NCI) Clinical Proteomic Tumor Analysis Consortium (CPTAC) scientists have released a dataset of proteins and phophorylated phosphopeptides identified through deep proteomic and phosphoproteomic analysis of breast tumor samples, previously genomically analyzed by The Cancer Genome Atlas (TCGA).

  12. Breast cancer research in Asia : Adopt or adapt Western knowledge?

    NARCIS (Netherlands)

    Bhoo-Pathy, Nirmala; Yip, Cheng-Har; Hartman, Mikael; Uiterwaal, Cuno S. P. M.; Devi, Beena C. R.; Peeters, Petra H. M.; Taib, Nur Aishah; van Gils, Carla H.; Verkooijen, Helena M.

    2013-01-01

    The incidence and mortality of breast cancer continues to rise rapidly in Asian countries. However, most of our current knowledge on breast cancer has been generated in Western populations. As the socio-economic profile, life style and culture of Asian and Western women are substantially different,

  13. Integrating Genomics with Proteomics - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    Approximately 60 percent of patients diagnosed with cancer present as early stage disease (Stage I and II). Despite the favorable prognosis associated with treatment intervention of such early stage disease (typically surgical excision), there are a small, but significant, fraction of these cancers that appear to be hardwired for aggressive metastatic behavior and ultimately lethal outcome.

  14. A CLASSROOM BASED RESEARCH PROJECT INCORPORATING ENGLISH FOR SPECIAL PURPOSES (ESP) METHODOLOGY PREPARONG JAPANESE STUDENTS FOR HOMESTAY IN AUSTRALIA

    OpenAIRE

    Nadasdy,Paul Bela

    2010-01-01

    English for Special Purposes (ESP) lesson materials were created for Japanese high school students going on homestay to Cairns, Australia. The lessons were designed specifically for situations that the students would encounter with their homestay families and at the school they would attend regularly during their stay. After teaching the lessons, and after the subsequent homestay, students were interviewed and asked about the effectiveness of the materials. Most said that they and enjoyed the...

  15. Doing Research on People with Learning Disabilities, Cancer and Dying: Ethics, Possibilities and Pitfalls

    Science.gov (United States)

    Tuffrey-Wijne, Irene; Bernal, Jane; Hollins, Sheila

    2008-01-01

    We have done research about cancer, death and dying. People with learning disabilities who had cancer were in our studies. This paper is about making sure that our research is ethical. This means that we don't want to cause any harm (or make people upset) when we do the research. We ask: (1) How do we find people to be in our studies?; (2) What…

  16. Trends in Research on Energy Balance Supported by the National Cancer Institute

    OpenAIRE

    Ballard-Barbash, Rachel; Siddiqi, Sameer M.; Berrigan, David A.; Ross, Sharon A.; Nebeling, Linda C.; Dowling, Emily C.

    2013-01-01

    Over the past decade, the body of research linking energy balance to the incidence, development, progression and treatment of cancer has grown substantially. No prior NIH portfolio analyses have focused on energy balance within one institute. This portfolio analysis describes the growth of National Cancer Institute (NCI) grant research on energy balance–related conditions and behaviors from 2004 to 2010 following the release of an NCI research priority statement in 2003 on energy balance and ...

  17. Research on English Oral Test Based on Projects in Higher Vocational Education%基于项目的高职英语口语测试研究

    Institute of Scientific and Technical Information of China (English)

    杨春艳

    2015-01-01

    As the development of project teaching of English in higher vocational education ,the traditional way of oral test fails to match with the teaching process. In this paper ,the research and discussion of the oral test is carried out based on the project.%随着项目化教学在高职英语教学中的发展,传统的口语测试方式逐渐与教学相脱节。文章对基于项目的口语测试进行了研究与探讨。

  18. Screening for cervical cancer: new alternatives and research

    Directory of Open Access Journals (Sweden)

    Lörincz Attila T

    2003-01-01

    appears that HPV DNA testing is on the way to becoming a common testing strategy in cervical cancer prevention programs. Research continues into approaches for improving the performance and cost-effectiveness of HPV detection methods. Hybrid Capture 3 will offer improved HPV typing capabilities and the Rapid Capture machine allows for robot- assisted HPV DNA testing, permitting greater test throughput. PCR test improvements are expected to contribute to the growth of flexible accurate and cost-effective HPV DNA tests. It is likely that improved diagnostic technology along with HPV genotyping and quantitation may provide more value in future. A particularly promising approach is to combine HPV DNA testing with expression levels of other markers such as proliferative or cell cycle regulatory proteins to subdivide HPV- positive women into those who are at greater risk of cancer and those who can be safely followed by screening at longer intervals.

  19. [Cancer treatment in elderly patients: evidence and clinical research].

    Science.gov (United States)

    Repetto, Lazzaro; Luciani, Andrea

    2015-01-01

    showed a good sensibility (87.3%) but a low specificity (62%) with respect to CGA for the diagnosis of patients with disabilities. Overcash et al. proposed an abbreviated form of CGA using a reduced number of items of ADL, IADL, MMSE and GDS. There was a good correlation between complete and reduced scales (coefficient of correlation 0.8). G8 is a screening tool composed of 8 questions that explore functional, cognitive and nutritional status. The score with the best equilibrium between sensibility and specificity was 14 (sensibility 85% and specificity 65%). In the first observational trial age, hystotype, chemotherapy dose, haemoglobin (man: 11 g/dL; women: 10 g/dL), creatinine clearance less than 34 mL/min (Jelliffe formula), earing problems, at least a fall in the last six months, walking problems, low social activity, were related to a major risk of toxicity; in another trial IADL, diastolic blood pressure, LDH and MAX2 index were predictive of haematological toxicity, while performance status, Mini-Mental Status score, Mini-Nutritional Assessment (MNA) score and MAX2 index were predictive of non haematological toxicity. Based on these parameters a 0-2 score was developed. A recent "position article" of EORTC (European organization for Research and Treatment of Cancer) and SIOG analyzed the pro and the contra of the use of some indicators in elderly patients. The overall survival (OS) frequently used in classical clinical trial could give wrong messages as there are some competitive risks of death in elderly patients. Another important indicator is the disease specific survival (DSS). Concerning the design of clinical trials, a possible strategy is to enrol elderly patients without upper age limit and to plan stratification. An interesting trial design is the so called "extended trial" that allow to re-open the arm of a trial in which a too low number of older patients was enrolled. PMID:25621776

  20. Astronomy and Cancer Research: X-Rays and Nanotechnology from Black Holes to Cancer Therapy

    Science.gov (United States)

    Pradhan, Anil K.; Nahar, Sultana N.

    It seems highly unlikely that any connection is to be found between astronomy and medicine. But then it also appears to be obvious: X-rays. However, that is quite superficial because the nature of X-rays in the two disciplines is quite different. Nevertheless, we describe recent research on exactly that kind of link. Furthermore, the linkage lies in atomic physics, and via spectroscopy which is a vital tool in astronomy and may also be equally valuable in biomedical research. This review begins with the physics of black hole environments as viewed through X-ray spectroscopy. It is then shown that similar physics can be applied to spectroscopic imaging and therapeutics using heavy-element (high-Z) moieties designed to target cancerous tumors. X-ray irradiation of high-Z nanomaterials as radiosensitizing agents should be extremely efficient for therapy and diagnostics (theranostics). However, broadband radiation from conventional X-ray sources (such as CT scanners) results in vast and unnecessary radiation exposure. Monochromatic X-ray sources are expected to be considerably more efficient. We have developed a new and comprehensive methodology—Resonant Nano-Plasma Theranostics (RNPT)—that encompasses the use of monochromatic X-ray sources and high-Z nanoparticles. Ongoing research entails theoretical computations, numerical simulations, and in vitro and in vivo biomedical experiments. Stemming from basic theoretical studies of Kα resonant photoabsorption and fluorescence in all elements of the Periodic Table, we have established a comprehensive multi-disciplinary program involving researchers from physics, chemistry, astronomy, pathology, radiation oncology and radiology. Large-scale calculations necessary for theory and modeling are done at a variety of computational platforms at the Ohio Supercomputer Center. The final goal is the implementation of RNPT for clinical applications.

  1. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Adult Cancers Metastatic Cancer Recurrent Cancer Research NCI’s Role in Cancer Research Intramural Research Extramural Research Bioinformatics ... Terminology Resources NCI Data Catalog Cryo-EM NCI's Role in Cancer Research Intramural Research Extramural Research Bioinformatics ...

  2. Contrast between China English and Chinese English

    Institute of Scientific and Technical Information of China (English)

    杨公建

    2014-01-01

    With the globalization of English,the discussion about China English and Chinese English attracts many scholars’ interest and attention.The concept of China English and Chinese English usual y makes people confused, so the article wil make some tentative contrasts in terms of definition、attributes and causes of the two terms and make people have a clear comprehension of China English and Chinese English.

  3. English Movies and English Learning in College

    Institute of Scientific and Technical Information of China (English)

    张爽

    2015-01-01

    Nowadays, English movies have been considered as one of the most effective ways to assist students to keep interest in improving their English abilities and enlarge their English vocabularies, as well as their cross cultural communicative ability. Based on the functions of English movies, which make them meet the needs of college students’English acquisition, this paper ana⁃lyzes the advantages of English movies in English learning.

  4. The English Movies and the English Learning

    Institute of Scientific and Technical Information of China (English)

    孔琳琳

    2014-01-01

    English learning has always been a big problem to Chinese learners. The learners pay much more attention to the vocabulary and the grammar. Acctually, they can hardly speak English as native speakers and never really understand the English because the real English environment doesn’t exist in our country in which English is only used as a foreign language. Then English movies provide the learners with what they need in English learning.

  5. A study of the extent to which university English education fulfills workplace requirements for Vietnamese graduates and of the extent to which action research can lead to improvements in university English education

    OpenAIRE

    Vo, Thi Hong Le

    2014-01-01

    This study focuses on possible approaches that can be undertaken at university to prepare undergraduate students with English language communicative competence required at the workplace. In exploring how English is taught at a university and whether English education met the needs of business, the main concern of this study is how materials design and teacher education can support learners to develop the skills to communicate effectively in the Vietnamese workplace. The purpose of the stud...

  6. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Services Advance Directives Using Trusted Resources Cancer Types Adolescents and Young Adults with Cancer Reports, Research, and ... of Cancers Cancers by Body Location Childhood Cancers Adolescent & Young Adult Cancers Metastatic Cancer Recurrent Cancer Research ...

  7. NCI Approves Funding Plan for NCI Community Oncology Research Program (NCORP) | Division of Cancer Prevention

    Science.gov (United States)

    On June 24, 2014, the Scientific Program Leaders (SPL) of the National Cancer Institute (NCI) approved the funding plan for the NCI Community Oncology Research Program (NCORP), a national network of investigators, cancer care providers, academic institutions, and other organizations. NCORP will conduct multi-site cancer clinical trials and studies in diverse populations in community-based healthcare systems across the United States. The program will receive $93 million a year for five years. |

  8. Introducing Students to Cancer Prevention Careers through Programmed Summer Research Experiences

    OpenAIRE

    Cameron, Carrie; Collie, Candice L.; Chang, Shine

    2012-01-01

    Training programs in cancer prevention research play an important role in addressing impending shortages in the cancer prevention workforce. Published reports on the effectiveness of these programs, however, often focus on a program’s success in recruiting and retaining a demographically diverse trainee population or on academic successes of the trainees, in general. Little has been reported about programs’ success in stimulating long-term interest in cancer prevention per se, whether in rese...

  9. An Auto-Ethnographic Study of the Disembodied Experience of a Novice Researcher Doing Qualitative Cancer Research.

    Science.gov (United States)

    Benoot, Charlotte; Bilsen, Johan

    2016-03-01

    Qualitative health researchers who explore individuals' experiences of illness are exposed to an emotionally demanding work environment. After doing 49 interviews with cancer patients living alone, I was confronted with serious emotional distress that kept me from my work for almost 6 months. Because there is a need for discussion within academia about the emotional risks encountered by researchers, I used auto-ethnography to explore what I call the "three disembodied experiences" I encountered during the research: disembodiment linked with suppression of emotions, disembodiment linked with distal traumatization, and disembodiment linked with overidentification with the participant. I illustrate these concepts with personal stories of doing research with cancer patients living alone. I conclude that writing down experiences of doing qualitative research in an embodied and reflexive way holds two advantages: It can protect the researcher and enhance the quality of research. PMID:26612885

  10. Current Perspectives on Teaching World Englishes and English as a Lingua Franca

    Science.gov (United States)

    Jenkins, Jennifer

    2006-01-01

    The purpose of this article is to explore recent research into World Englishes (henceforth WEs) and English as a Lingua Franca (ELF), focusing on its implications for TESOL, and the extent to which it is being taken into account by English language teachers, linguists, and second language acquisition researchers. After a brief introduction…

  11. Eurocan plus report: feasibility study for coordination of national cancer research activities.

    Science.gov (United States)

    2008-01-01

    The EUROCAN+PLUS Project, called for by the European Parliament, was launched in October 2005 as a feasibility study for coordination of national cancer research activities in Europe. Over the course of the next two years, the Project process organized over 60 large meetings and countless smaller meetings that gathered in total over a thousand people, the largest Europe-wide consultation ever conducted in the field of cancer research.Despite a strong tradition in biomedical science in Europe, fragmentation and lack of sustainability remain formidable challenges for implementing innovative cancer research and cancer care improvement. There is an enormous duplication of research effort in the Member States, which wastes time, wastes money and severely limits the total intellectual concentration on the wide cancer problem. There is a striking lack of communication between some of the biggest actors on the European scene, and there are palpable tensions between funders and those researchers seeking funds.It is essential to include the patients' voice in the establishment of priority areas in cancer research at the present time. The necessity to have dialogue between funders and scientists to establish the best mechanisms to meet the needs of the entire community is evident. A top priority should be the development of translational research (in its widest form), leading to the development of effective and innovative cancer treatments and preventive strategies. Translational research ranges from bench-to-bedside innovative cancer therapies and extends to include bringing about changes in population behaviours when a risk factor is established.The EUROCAN+PLUS Project recommends the creation of a small, permanent and independent European Cancer Initiative (ECI). This should be a model structure and was widely supported at both General Assemblies of the project. The ECI should assume responsibility for stimulating innovative cancer research and facilitating processes

  12. Validation of the Korean version of the European Organization for Research and Treatment of Cancer brain cancer module (EORTC QLQ-BN20) in patients with brain tumors

    OpenAIRE

    Shin, Yong Soon; Kim, Jeong Hoon

    2013-01-01

    Background The European Organization for Research and Treatment of Cancer Quality of Life Brain Cancer Module has been translated into Korean, but to date, its reliability and validity have been evaluated in a pilot study alone. The European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire is, overall, a valid instrument to assess the health-related quality of life in Korean cancer patients, although its reliability and validity have not yet been evaluated ...

  13. BODIPY-FL Nilotinib (Tasigna) for Use in Cancer Research | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The National Cancer Institute''s Laboratory of Cell Biology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize bodipy conjugated tyrosine kinase inhibitors that are currently used in the clinic for the treatment of CML or gastric cancers.

  14. Research Strategies for Nutritional and Physical Activity Epidemiology and Cancer Prevention

    Science.gov (United States)

    In response to a series of controversial articles about nutritional epidemiology and cancer published in 2014, staff from the Environmental Epidemiology Branch initiated a series of meetings to refine programmatic priorities for human nutrition/physical activity and cancer etiology research in the near term.

  15. Critical Appraisal of Translational Research Models for Suitability in Performance Assessment of Cancer Centers

    OpenAIRE

    Rajan, Abinaya; Sullivan, Richard; Bakker, Suzanne; van Harten, Wim H.

    2012-01-01

    This study aimed to critically appraise translational research models for suitability in performance assessment of cancer centers. Process models, such as the Process Marker Model and Lean and Six Sigma applications, seem to be suitable for performance assessment of cancer centers. However, they must be thoroughly tested in practice.

  16. New Funding Opportunity: Biospecimen Core Resource - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The purpose of this notice is to notify the community that the National Cancer Institute's (NCI’s) Office of Cancer Clinical Proteomics Research (OCCPR) is seeking sources to establish a Biospecimen Core Resource (BCR), capable of receiving, qualifying, processing, and distributing annotated biospecimens.

  17. New Funding Opportunity: Tissue Purchase Order Acquisitions - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The National Cancer Institute (NCI) is expanding its basic and translational research programs that rely heavily on sufficient availability of high quality, well annotated biospecimens suitable for use in genomic and proteomic studies. The NCI’s overarching goal with such programs is to improve the ability to diagnose, treat, and prevent cancer.

  18. Approaches to Art Therapy for Cancer Inpatients: Research and Practice Considerations

    Science.gov (United States)

    Nainis, Nancy A.

    2008-01-01

    Common symptoms reported by cancer patients include pain, fatigue, breathlessness, insomnia, lack of appetite, and anxiety. A study conducted by an interdisciplinary research team (Nainis et al., 2006) demonstrated statistically significant reductions in these cancer symptoms with the use of traditional art therapy methods. The study found a…

  19. Cancer, Employment, and American Indians: A Participatory Action Research Pilot Study

    Science.gov (United States)

    Johnson, Sharon R.; Finifrock, DeAnna; Marshall, Catherine A.; Jaakola, Julia; Setterquist, Janette; Burross, Heidi L.; Hodge, Felicia Schanche

    2011-01-01

    American Indian cancer survivors are an underserved and understudied group. In this pilot study we attempted to address, through participatory action research, missing information about those factors that serve to either facilitate employment or hinder it for adult cancer survivors. One task of the study was to develop and/or modify…

  20. Antibody Request - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    In an effort to provide well-characterized monoclonal antibodies to the scientific community, NCI's Antibody Characterization Program requests cancer-related protein targets for affinity production and distribution.

  1. Stem cells in radiation and oral cancer research

    International Nuclear Information System (INIS)

    Cancer stem cells (CSCs) are defined as a small sub population of cancer cells that constitute a pool of self sustaining cells with the exclusive ability to cause the heterogeneous lineages of cancer cells that comprise the tumour. There are three main characteristics of CSCs. Initially the cell must show potent tumour initiation in that it can regenerate the tumour which it was derived from a limited number of cells. In addition, the cells should demonstrate self renewal in vivo, which is practically observed via regrowth of phenotypically indistinguishable and heterogeneous tumours following serial transplantation of re-isolated CSCs in secondary and tertiary recipients. Finally, the cells must show a differentiation capacity, allowing them to give rise to a heterogeneous progeny, which represents a phenocopy of the original tumour. This article highlights the radiation therapy resulting in radiation resistance in cancer stem cells. (author)

  2. What's New in Laryngeal and Hypopharyngeal Cancer Research and Treatment?

    Science.gov (United States)

    ... define surgical margins (check to see if all cancer cells have been removed) and to tell which tumors may respond better to surgery or radiation therapy. These tests are still experimental and are not used in the routine care ...

  3. Caring for caregivers and patients: Research and clinical priorities for informal cancer caregiving.

    Science.gov (United States)

    Kent, Erin E; Rowland, Julia H; Northouse, Laurel; Litzelman, Kristin; Chou, Wen-Ying Sylvia; Shelburne, Nonniekaye; Timura, Catherine; O'Mara, Ann; Huss, Karen

    2016-07-01

    Informal/family caregivers are a fundamental source of care for cancer patients in the United States, yet the population of caregivers and their tasks, psychosocial needs, and health outcomes are not well understood. Changes in the nature of cancer care and its delivery, along with the growing population of survivors and their caregivers, warrant increased attention to the roles and demands of caregiving. This article reviews current evidence presented at a 2-day meeting examining the state of the science of informal cancer caregiving that was convened by the National Cancer Institute and the National Institute of Nursing Research. The meeting sought to define who is an informal cancer caregiver, summarize the state of the science in informal cancer caregiving, and describe both the kinds of interventions developed to address caregiving challenges and the various outcomes used to evaluate their impact. This article offers recommendations for moving science forward in 4 areas: 1) improving the estimation of the prevalence and burden of informal cancer caregiving; 2) advancing the development of interventions designed to improve outcomes for cancer patients, caregivers, and patient-caregiver dyads; 3) generating and testing strategies for integrating caregivers into formal health care settings; and 4) promoting the use of technology to support informal cancer caregivers. Cancer 2016;122:1987-95. © 2016 American Cancer Society. PMID:26991807

  4. Gastric cancer research in Mexico: A public health priority

    OpenAIRE

    Sampieri, Clara Luz; Mora, Mauricio

    2014-01-01

    This study aimed review studies conducted on Mexican patients diagnosed with gastric cancer and/or diseases associated with its development, in which at least one Mexican institute has participated, and to assess their contributions to the primary and secondary prevention of this disease. A search of the Medline database was conducted using the following keywords: gastric/stomach cancer, Mexico. Studies of the Mexican population were selected in which at least one Mexican Institute had partic...

  5. English II: ENG 152.

    Science.gov (United States)

    Hudson, James

    A course guide for students in English 152 of Oakland Community College, a composition course in argumentative writing, this document gives the class schedule, the course outline, examples of writing, worksheets, ways of preparing bibliography and note cards, checklists, and a research bibliography, as well as presenting other cogent materials.…

  6. Facilitating the Transition of Limited English Proficient Students From Their Native Language to English

    OpenAIRE

    Infantino, Jean Anne

    2005-01-01

    The purpose of this research was to learn how teachers, school division policies, and community influences facilitated the transition of middle school Limited English Proficient (LEP) students from their native language to English. The research questions are: (1) How did the content area teachers influence the LEP student with learning English? (2) How did the ESL teacher influence the LEP student with learning English? (3) How did the school division policies influence the LEP student with l...

  7. Translating cancer prevention and control research into the community setting: workforce implications.

    Science.gov (United States)

    Harrop, J Phil; Nelson, David E; Kuratani, Darrah Goo; Mullen, Patricia Dolan; Paskett, Electra D

    2012-05-01

    A gap exists between cancer prevention research and its translation into community practice. Two strategies to reduce this gap are community-based participatory research (CBPR) and dissemination research. CBPR offers an avenue to engage academic and community partners, thereby providing mechanisms for joint learning and application of knowledge. Dissemination research examines the movement of evidence-based public health and clinical innovations to practice settings. While applying these approaches may reduce the gap between research and practice, the cancer prevention workforce may be inadequate in size, insufficiently trained, lack resources and incentives, or face structural barriers to effectively participate in CBPR and disseminate evidence-based research findings into practice. Information on translating cancer prevention information to communities and workforce implications was obtained from a panel of experts and through a review of the literature on CBPR and dissemination research. The expert panel and literature review identified major barriers to successfully conducting CBPR and dissemination research in community settings. Barriers included inadequate policies; insufficient networking and communication infrastructures; unsupportive research cultures, climates, and mindsets; inadequate researcher and practitioner education; and limited CBPR and dissemination research with adequate study designs. No specific estimates of the cancer prevention workforce were found; however, indirect evidence for a shortfall were identified. We recommend expanding CBPR training for academic and community partners; increasing funding for dissemination research and practice; supporting proven partnerships; and providing strategic coordination for government agencies, research institutions, nongovernmental organizations, and the private sector to foster better dissemination of information and integration of community-based cancer prevention and control programs and practices

  8. The Research Progress about Wnt Pathway of Lung Cancer Stem Cells

    Directory of Open Access Journals (Sweden)

    Xiaojiang LI

    2011-08-01

    Full Text Available Being the most critical signaling molecule in the Wnt pathway, the Wnt/β-catenin signaling pathway plays an important role in the maintenance of the cell proliferation and clone formation of lung cancer stem cells. Since it is closely related to the WNT pathway, the proliferation of lung cancer stem cells can be restrained by blocking the WNT pathway or influencing its key protein. Such method provides a new method for the treatment of lung cancer. By summarizing the state of-the-art research of lung cancer stem cells and the Wnt pathway from 2005 to 2010, their relationship is investigated.

  9. CPTAC Contributes to Healthdata.gov - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    Recently, proteomic data generated by the Clinical Proteomic Tumor Analysis Consortium (CPTAC) funded by National Cancer Institute (NCI) was highlighted to the wider research community at Healthdata.gov. Healthdata.gov aims to make health data more acces

  10. Ovarian Cancer Proteomic, Phosphoproteomic, and Glycoproteomic Data Released - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    National Cancer Institute (NCI) Clinical Proteomic Tumor Analysis Consortium (CPTAC) scientists have just released a comprehensive dataset of the proteomic analysis of high grade serous ovarian tumor samples,

  11. Breast Cancer Rates by State

    Science.gov (United States)

    ... Associated Lung Ovarian Prostate Skin Uterine Cancer Home Breast Cancer Rates by State Language: English Español (Spanish) Recommend ... from breast cancer each year. Rates of Getting Breast Cancer by State The number of people who get ...

  12. Skin Cancer Trends

    Science.gov (United States)

    ... Search The CDC Cancel Submit Search The CDC Skin Cancer Note: Javascript is disabled or is not supported ... Cervical Colorectal (Colon) Lung Ovarian Prostate Cancer Home Skin Cancer Trends Language: English Español (Spanish) Recommend on Facebook ...

  13. About the Community Oncology and Prevention Trials Research Group | Division of Cancer Prevention

    Science.gov (United States)

    The Community Oncology and Prevention Trials Research Group supports clinical oncology trials in cancer prevention and control in community settings. The group also supports investigator-initiated research projects in supportive, palliative and end-of-life care, and coordinates clinical oncology research projects with other NCI programs to be done in the community setting. |

  14. Participation of Asian-American Women in Cancer Chemoprevention Research: Physician Perspectives

    OpenAIRE

    Nguyen, Tung T.; Somkin, Carol P.; Ma, Yifei

    2005-01-01

    To the authors’ knowledge, little is known regarding the participation of Asian Americans in cancer prevention research. In 2002, the authors mailed surveys to primary care physicians in Northern California to assess their knowledge, attitudes, behaviors, and barriers concerning the participation of Asian-American women in breast cancer chemoprevention research. The response rate was 52.3% (n = 306 physicians). For physician barriers, most respondents selected lack of study knowledge (73%) an...

  15. Characteristics of breast cancer survivors that predict partners' participation in research

    OpenAIRE

    Christie, KM; Meyerowitz, BE; Stanton, AL; Rowland, JH; Ganz, PA

    2013-01-01

    Background: Psycho-oncology couples' research frequently includes fewer than 50 % of those eligible. Purpose: This research examined individual and relationship characteristics associated with recruitment and retention of breast cancer survivors' partners. Methods: Investigators asked survivors from the Moving Beyond Cancer trial for permission to invite their partners to a parallel, longitudinal study. Results: Of 384 survivors with male partners, 280 survivors provided consent to contact pa...

  16. Building a funded research program in cancer health disparities: considerations for young investigators

    OpenAIRE

    Heather M. Ochs-Balcom; Phillips, Lynette S.; Nichols, Hazel B.; Martinez, Elena; Thompson, Beti; Ojeifo, John; Rebbeck, Timothy R.

    2015-01-01

    A workshop entitled “Building a funded research program in cancer health disparities” was held at the 38th Annual American Society of Preventive Oncology (ASPO) Meeting. Organized by the Junior Members Interest Group, the session addressed topics relevant to career development for cancer disparities investigators. Such considerations include the development of research programs on a backdrop of existing multi- and trans-disciplinary teams, recognizing opportunities for advancing their researc...

  17. Tracing convergence and divergence in pairs of Spanish and English research article abstracts: The case of Ibérica

    Directory of Open Access Journals (Sweden)

    Moisés Perales-Escudero

    2011-04-01

    Full Text Available This paper investigates patterns of rhetorical convergence and divergence in pairs of RA abstracts (English-Spanish and Spanish-English published in the journal Ibérica. To that end, a total of 84 pairs of author-translated RA abstracts were analyzed. Based on the results of a pilot study, the following rhetorical patterns were analyzed in the corpus: text-referring expressions, degree of epistemic commitment, amplified attitude, self-mention, and periphrastic (e.g. multi-word expressions. In addition, selected authorial input was requested to seek further explanations about the variation across these two languages. For text-referring expressions, broad cross-linguistic convergence was found in the expressions used and the degree to which the text is given agency. By contrast, the abstracts in Spanish were found to include greater degree of epistemic commitment, more amplified expressions of attitude, more self-mention, particularly in the plural first person, and periphrastic equivalents. Authorial input indicated that some of these diverging patterns were due to collocational differences but they were also influenced by beliefs about what is more natural in Spanish. Our results suggest that there may be specific lexical bundles performing intensifying functions in Spanish that deserve further investigation. These findings may have implications for ESP pedagogy and translation studies.

  18. The Links of the Phenomenon and Research between the Junior and Senior English Study---Counter Measures and Research on the Transformation of Students with Learning Difficulties in English%浅谈初、高中英语学科衔接的现状和研究--转变英语学困生的对策和研究

    Institute of Scientific and Technical Information of China (English)

    张巧玲

    2014-01-01

    In recent junior-senior school studies especially English ,most of the teachers have paid more attention to analysis and solutions of some particular problems or experience description. Instead,attach less importance to the general and whole research or theory result. Among these problems,the education of students in difficulties in English is the most terrible matter for most of the teachers and parents.%在初、高中英语衔接过程中,多数教师只关注学段过渡时期个别问题的分析及其解决办法,其中英语学困生的教育更是一个让许多教师和家长头疼的问题。

  19. IT behind a platform for Translational Cancer Research - concept and objectives.

    Science.gov (United States)

    Steffens, Michael; Husmann, Gabriele; Koca, Mithat; Lablans, Martin; Komor, Martina; Zeissig, Sylke; Emrich, Katharina; Brandts, Christian; Serve, Hubert; Blettner, Maria; Uckert, Frank

    2012-01-01

    The German Consortium for Translational Cancer Research (DKTK) and the Rhine-Main Translational Cancer Research Network (RM-TCRN) are designed to exploit large population cohorts of cancer patients for the purpose of bio-banking, clinical trials, and clinical cancer registration. Hence, the success of these platforms is heavily dependent on the close interlinking of clinical data from cancer patients, information from study registries, and data from bio-banking systems of different laboratories and scientific institutions. This article referring to the poster discusses the main challenges of the platforms from an information technology point of view, legal and data security issues, and outlines an integrative IT-concept concerning a decentralized, distributed search approach where data management and search is in compliance with existing legislative rules. PMID:22874378

  20. A Federated Network for Translational Cancer Research Using Clinical Data and Biospecimens.

    Science.gov (United States)

    Jacobson, Rebecca S; Becich, Michael J; Bollag, Roni J; Chavan, Girish; Corrigan, Julia; Dhir, Rajiv; Feldman, Michael D; Gaudioso, Carmelo; Legowski, Elizabeth; Maihle, Nita J; Mitchell, Kevin; Murphy, Monica; Sakthivel, Mayurapriyan; Tseytlin, Eugene; Weaver, JoEllen

    2015-12-15

    Advances in cancer research and personalized medicine will require significant new bridging infrastructures, including more robust biorepositories that link human tissue to clinical phenotypes and outcomes. In order to meet that challenge, four cancer centers formed the Text Information Extraction System (TIES) Cancer Research Network, a federated network that facilitates data and biospecimen sharing among member institutions. Member sites can access pathology data that are de-identified and processed with the TIES natural language processing system, which creates a repository of rich phenotype data linked to clinical biospecimens. TIES incorporates multiple security and privacy best practices that, combined with legal agreements, network policies, and procedures, enable regulatory compliance. The TIES Cancer Research Network now provides integrated access to investigators at all member institutions, where multiple investigator-driven pilot projects are underway. Examples of federated search across the network illustrate the potential impact on translational research, particularly for studies involving rare cancers, rare phenotypes, and specific biologic behaviors. The network satisfies several key desiderata including local control of data and credentialing, inclusion of rich phenotype information, and applicability to diverse research objectives. The TIES Cancer Research Network presents a model for a national data and biospecimen network. PMID:26670560