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Sample records for cancer redox steering

  1. Redox Regulation in Cancer Stem Cells

    OpenAIRE

    Shijie Ding; Chunbao Li; Ninghui Cheng; Xiaojiang Cui; Xinglian Xu; Guanghong Zhou

    2015-01-01

    Reactive oxygen species (ROS) and ROS-dependent (redox regulation) signaling pathways and transcriptional activities are thought to be critical in stem cell self-renewal and differentiation during growth and organogenesis. Aberrant ROS burst and dysregulation of those ROS-dependent cellular processes are strongly associated with human diseases including many cancers. ROS levels are elevated in cancer cells partially due to their higher metabolism rate. In the past 15 years, the concept of can...

  2. Redox regulation in cancer stem cells

    Science.gov (United States)

    Reactive oxygen species (ROS) and ROS-dependent (redox regulation) signaling pathways and transcriptional activities are thought to be critical in stem cell self-renewal and differentiation during growth and organogenesis. Aberrant ROS burst and dysregulation of those ROS-dependent cellular processe...

  3. Redox-Mediated Suberoylanilide Hydroxamic Acid Sensitivity in Breast Cancer

    Science.gov (United States)

    Chiaradonna, Ferdinando; Barozzi, Iros; Miccolo, Claudia; Bucci, Gabriele; Palorini, Roberta; Fornasari, Lorenzo; Botrugno, Oronza A.; Pruneri, Giancarlo; Masullo, Michele; Passafaro, Alfonso; Galimberti, Viviana E.; Fantin, Valeria R.; Richon, Victoria M.; Pece, Salvatore; Viale, Giuseppe; Di Fiore, Pier Paolo; Draetta, Giulio; Pelicci, Pier Giuseppe

    2015-01-01

    Abstract Aims: Vorinostat (suberoylanilide hydroxamic acid; SAHA) is a histone deacetylase inhibitor (HDACi) approved in the clinics for the treatment of T-cell lymphoma and with the potential to be effective also in breast cancer. We investigated the responsiveness to SAHA in human breast primary tumors and cancer cell lines. Results: We observed a differential response to drug treatment in both human breast primary tumors and cancer cell lines. Gene expression analysis of the breast cancer cell lines revealed that genes involved in cell adhesion and redox pathways, especially glutathione metabolism, were differentially expressed in the cell lines resistant to SAHA compared with the sensitive ones, indicating their possible association with drug resistance mechanisms. Notably, such an association was also observed in breast primary tumors. Indeed, addition of buthionine sulfoximine (BSO), a compound capable of depleting cellular glutathione, significantly enhanced the cytotoxicity of SAHA in both breast cancer cell lines and primary breast tumors. Innovation: We identify and validate transcriptional differences in genes involved in redox pathways, which include potential predictive markers of sensitivity to SAHA. Conclusion: In breast cancer, it could be relevant to evaluate the expression of antioxidant genes that may favor tumor resistance as a factor to consider for potential clinical application and treatment with epigenetic drugs (HDACis). Antioxid. Redox Signal. 23, 15–29. PMID:25897982

  4. The redox biology network in cancer pathophysiology and therapeutics

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    Gina Manda

    2015-08-01

    Full Text Available The review pinpoints operational concepts related to the redox biology network applied to the pathophysiology and therapeutics of solid tumors. A sophisticated network of intrinsic and extrinsic cues, integrated in the tumor niche, drives tumorigenesis and tumor progression. Critical mutations and distorted redox signaling pathways orchestrate pathologic events inside cancer cells, resulting in resistance to stress and death signals, aberrant proliferation and efficient repair mechanisms. Additionally, the complex inter-cellular crosstalk within the tumor niche, mediated by cytokines, redox-sensitive danger signals (HMGB1 and exosomes, under the pressure of multiple stresses (oxidative, inflammatory, metabolic, greatly contributes to the malignant phenotype. The tumor-associated inflammatory stress and its suppressive action on the anti-tumor immune response are highlighted. We further emphasize that ROS may act either as supporter or enemy of cancer cells, depending on the context. Oxidative stress-based therapies, such as radiotherapy and photodynamic therapy, take advantage of the cytotoxic face of ROS for killing tumor cells by a non-physiologically sudden, localized and intense oxidative burst. The type of tumor cell death elicited by these therapies is discussed. Therapy outcome depends on the differential sensitivity to oxidative stress of particular tumor cells, such as cancer stem cells, and therefore co-therapies that transiently down-regulate their intrinsic antioxidant system hold great promise. We draw attention on the consequences of the damage signals delivered by oxidative stress-injured cells to neighboring and distant cells, and emphasize the benefits of therapeutically triggered immunologic cell death in metastatic cancer. An integrative approach should be applied when designing therapeutic strategies in cancer, taking into consideration the mutational, metabolic, inflammatory and oxidative status of tumor cells, cellular

  5. NAC selectively inhibit cancer telomerase activity: A higher redox homeostasis threshold exists in cancer cells

    OpenAIRE

    Pengying Li; Meilin Wu; Jing Wang; Yilun Sui; Shanlin Liu; Dongyun Shi

    2016-01-01

    Telomerase activity controls telomere length, and this plays an important role in stem cells, aging and tumors. Antioxidant was shown to protect telomerase activity in normal cells but inhibit that in cancer cells, but the underlying mechanism is elusive. Here we found that 7721 hepatoma cells held a higher redox homeostasis threshold than L02 normal liver cells which caused 7721 cells to have a higher demand for ROS; MnSOD over-expression in 7721 decreased endogenous reactive oxygen species ...

  6. Redox-active and Redox-silent Compounds: Synergistic Therapeutics in Cancer

    Czech Academy of Sciences Publication Activity Database

    Tomasetti, M.; Santarelli, L.; Alleva, R.; Dong, L.F.; Neužil, Jiří

    2015-01-01

    Roč. 22, č. 5 (2015), s. 552-568. ISSN 0929-8673 R&D Projects: GA MŠk(CZ) ED1.1.00/02.0109 Institutional support: RVO:86652036 Keywords : Apoptosis * autophagy * redox-active agents Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.853, year: 2014

  7. Selective induction of oxidative stress in cancer cells via synergistic combinations of agents targeting redox homeostasis.

    Science.gov (United States)

    Akladios, Fady N; Andrew, Scott D; Parkinson, Christopher J

    2015-07-01

    Cancer cell resistance to chemotherapy is still a heavy burden that impairs the response of many cancer patients to conventional chemotherapy. Using drug combinations is one therapeutic approach to overcome the developing resistance to any one drug. Oxidative stress is now a generally regarded hallmark of cancer that can be one approach to selectively target cancer cells while sparing normal cells. With the aim of increasing oxidative stress in cancer cells to a lethal set point, we have generated and combined several series of redox active compounds that act at different points of the cellular oxidative cascade. The premise of such combinations is to deplete of endogenous antioxidant defence proteins (e.g., Glutathione) while concomitantly increasing the generation of ROS via metal redox recycling and Fenton chemistry which eventually leads to the disruption of cellular redox homeostasis and induction of cell death. Through this approach, we have identified highly synergistic combinations of two distinctive classes of compounds (Azines and Copper(II) complexes of 2-pyridyl ketone thiosemicarbazones) which are capable of eliminating cancer cells without concomitant increase in toxicity toward normal cells. In one of our most potent combinations, a combination index (CI) value of 0.056 was observed, representing a 17 fold enhancement in activity beyond additive effects. Such new combination regimen of redox active compounds can be one step closer to potentially safer low dose chemotherapy. PMID:26022081

  8. Redox Regulation in Cancer: A Double-edged Sword with Therapeutic Potential

    Directory of Open Access Journals (Sweden)

    Asha Acharya

    2010-01-01

    Full Text Available Oxidative stress, implicated in the etiology of cancer, results from an imbalance in the production of reactive oxygen species (ROS and cell’s own antioxidant defenses. ROS deregulate the redox homeostasis and promote tumor formation by initiating an aberrant induction of signaling networks that cause tumorigenesis. Ultraviolet (UV exposures, γ-radiation and other environmental carcinogens generate ROS in the cells, which can exert apoptosis in the tumors, thereby killing the malignant cells or induce the progression of the cancer growth by blocking cellular defense system. Cancer stem cells take the advantage of the aberrant redox system and spontaneously proliferate. Oxidative stress and gene-environment interactions play a significant role in the development of breast, prostate, pancreatic and colon cancer. Prolonged lifetime exposure to estrogen is associated with several kinds of DNA damage. Oxidative stress and estrogen receptor-associated proliferative changes are suggested to play important roles in estrogen-induced breast carcinogenesis. BRCA1, a tumor suppressor against hormone responsive cancers such as breast and prostate cancer, plays a significant role in inhibiting ROS and estrogen mediated DNA damage; thereby regulate the redox homeostasis of the cells. Several transcription factors and tumor suppressors are involved during stress response such as Nrf2, NFκB and BRCA1. A promising strategy for targeting redox status of the cells is to use readily available natural substances from vegetables, fruits, herbs and spices. Many of the phytochemicals have already been identified to have chemopreventive potential, capable of intervening in carcinogenesis.

  9. Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy

    Directory of Open Access Journals (Sweden)

    Barbara Marengo

    2016-01-01

    Full Text Available Reactive oxygen species (ROS and their products are components of cell signaling pathways and play important roles in cellular physiology and pathophysiology. Under physiological conditions, cells control ROS levels by the use of scavenging systems such as superoxide dismutases, peroxiredoxins, and glutathione that balance ROS generation and elimination. Under oxidative stress conditions, excessive ROS can damage cellular proteins, lipids, and DNA, leading to cell damage that may contribute to carcinogenesis. Several studies have shown that cancer cells display an adaptive response to oxidative stress by increasing expression of antioxidant enzymes and molecules. As a double-edged sword, ROS influence signaling pathways determining beneficial or detrimental outcomes in cancer therapy. In this review, we address the role of redox homeostasis in cancer growth and therapy and examine the current literature regarding the redox regulatory systems that become upregulated in cancer and their role in promoting tumor progression and resistance to chemotherapy.

  10. Radical Decisions in Cancer: Redox Control of Cell Growth and Death

    Energy Technology Data Exchange (ETDEWEB)

    Sainz, Rosa M., E-mail: sainzrosa@uniovi.es [Cellular Biology and Morphology Department, School of Medicine, University of Oviedo, Oviedo 33006 (Spain); University Institute of Oncology of Asturias (IUOPA), University of Oviedo, Oviedo 33006 (Spain); Lombo, Felipe [University Institute of Oncology of Asturias (IUOPA), University of Oviedo, Oviedo 33006 (Spain); Functional Biology Department, Area of Microbiology, School of Medicine, University of Oviedo, Oviedo 33006 (Spain); Mayo, Juan C. [Cellular Biology and Morphology Department, School of Medicine, University of Oviedo, Oviedo 33006 (Spain); University Institute of Oncology of Asturias (IUOPA), University of Oviedo, Oviedo 33006 (Spain)

    2012-04-25

    Free radicals play a key role in many physiological decisions in cells. Since free radicals are toxic to cellular components, it is known that they cause DNA damage, contribute to DNA instability and mutation and thus favor carcinogenesis. However, nowadays it is assumed that free radicals play a further complex role in cancer. Low levels of free radicals and steady state levels of antioxidant enzymes are responsible for the fine tuning of redox status inside cells. A change in redox state is a way to modify the physiological status of the cell, in fact, a more reduced status is found in resting cells while a more oxidative status is associated with proliferative cells. The mechanisms by which redox status can change the proliferative activity of cancer cells are related to transcriptional and posttranscriptional modifications of proteins that play a critical role in cell cycle control. Since cancer cells show higher levels of free radicals compared with their normal counterparts, it is believed that the anti-oxidative stress mechanism is also increased in cancer cells. In fact, the levels of some of the most important antioxidant enzymes are elevated in advanced status of some types of tumors. Anti-cancer treatment is compromised by survival mechanisms in cancer cells and collateral damage in normal non-pathological tissues. Though some resistance mechanisms have been described, they do not yet explain why treatment of cancer fails in several tumors. Given that some antitumoral treatments are based on the generation of free radicals, we will discuss in this review the possible role of antioxidant enzymes in the survival mechanism in cancer cells and then, its participation in the failure of cancer treatments.

  11. Radical Decisions in Cancer: Redox Control of Cell Growth and Death

    International Nuclear Information System (INIS)

    Free radicals play a key role in many physiological decisions in cells. Since free radicals are toxic to cellular components, it is known that they cause DNA damage, contribute to DNA instability and mutation and thus favor carcinogenesis. However, nowadays it is assumed that free radicals play a further complex role in cancer. Low levels of free radicals and steady state levels of antioxidant enzymes are responsible for the fine tuning of redox status inside cells. A change in redox state is a way to modify the physiological status of the cell, in fact, a more reduced status is found in resting cells while a more oxidative status is associated with proliferative cells. The mechanisms by which redox status can change the proliferative activity of cancer cells are related to transcriptional and posttranscriptional modifications of proteins that play a critical role in cell cycle control. Since cancer cells show higher levels of free radicals compared with their normal counterparts, it is believed that the anti-oxidative stress mechanism is also increased in cancer cells. In fact, the levels of some of the most important antioxidant enzymes are elevated in advanced status of some types of tumors. Anti-cancer treatment is compromised by survival mechanisms in cancer cells and collateral damage in normal non-pathological tissues. Though some resistance mechanisms have been described, they do not yet explain why treatment of cancer fails in several tumors. Given that some antitumoral treatments are based on the generation of free radicals, we will discuss in this review the possible role of antioxidant enzymes in the survival mechanism in cancer cells and then, its participation in the failure of cancer treatments

  12. Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance

    Directory of Open Access Journals (Sweden)

    Anna E. Maciag

    2013-01-01

    Full Text Available JS-K is a nitric oxide (NO-releasing prodrug of the O2-arylated diazeniumdiolate family that has demonstrated pronounced cytotoxicity and antitumor properties in a variety of cancer models both in vitro and in vivo. The current study of the metabolic actions of JS-K was undertaken to investigate mechanisms of its cytotoxicity. Consistent with model chemical reactions, the activating step in the metabolism of JS-K in the cell is the dearylation of the diazeniumdiolate by glutathione (GSH via a nucleophilic aromatic substitution reaction. The resulting product (CEP/NO anion spontaneously hydrolyzes, releasing two equivalents of NO. The GSH/GSSG redox couple is considered to be the major redox buffer of the cell, helping maintain a reducing environment under basal conditions. We have quantified the effects of JS-K on cellular GSH content, and show that JS-K markedly depletes GSH, due to JS-K's rapid uptake and cascading release of NO and reactive nitrogen species. The depletion of GSH results in alterations in the redox potential of the cellular environment, initiating MAPK stress signaling pathways, and inducing apoptosis. Microarray analysis confirmed signaling gene changes at the transcriptional level and revealed alteration in the expression of several genes crucial for maintenance of cellular redox homeostasis, as well as cell proliferation and survival, including MYC. Pre-treating cells with the known GSH precursor and nucleophilic reducing agent N-acetylcysteine prevented the signaling events that lead to apoptosis. These data indicate that multiplicative depletion of the reduced glutathione pool and deregulation of intracellular redox balance are important initial steps in the mechanism of JS-K's cytotoxic action.

  13. Cancer Therapy by Catechins Involves Redox Cycling of Copper Ions and Generation of Reactive Oxygen Species

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    Mohd Farhan

    2016-02-01

    Full Text Available Catechins, the dietary phytochemicals present in green tea and other beverages, are considered to be potent inducers of apoptosis and cytotoxicity to cancer cells. While it is believed that the antioxidant properties of catechins and related dietary agents may contribute to lowering the risk of cancer induction by impeding oxidative injury to DNA, these properties cannot account for apoptosis induction and chemotherapeutic observations. Catechin (C, epicatechin (EC, epigallocatechin (EGC and epigallocatechin-3-gallate (EGCG are the four major constituents of green tea. In this article, using human peripheral lymphocytes and comet assay, we show that C, EC, EGC and EGCG cause cellular DNA breakage and can alternatively switch to a prooxidant action in the presence of transition metals such as copper. The cellular DNA breakage was found to be significantly enhanced in the presence of copper ions. Catechins were found to be effective in providing protection against oxidative stress induced by tertbutylhydroperoxide, as measured by oxidative DNA breakage in lymphocytes. The prooxidant action of catechins involved production of hydroxyl radicals through redox recycling of copper ions. We also determined that catechins, particularly EGCG, inhibit proliferation of breast cancer cell line MDA-MB-231 leading to a prooxidant cell death. Since it is well established that tissue, cellular and serum copper levels are considerably elevated in various malignancies, cancer cells would be more subject to redox cycling between copper ions and catechins to generate reactive oxygen species (ROS responsible for DNA breakage. Such a copper dependent prooxidant cytotoxic mechanism better explains the anticancer activity and preferential cytotoxicity of dietary phytochemicals against cancer cells.

  14. Redox-Active Selenium Compounds—From Toxicity and Cell Death to Cancer Treatment

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    Sougat Misra

    2015-05-01

    Full Text Available Selenium is generally known as an antioxidant due to its presence in selenoproteins as selenocysteine, but it is also toxic. The toxic effects of selenium are, however, strictly concentration and chemical species dependent. One class of selenium compounds is a potent inhibitor of cell growth with remarkable tumor specificity. These redox active compounds are pro-oxidative and highly cytotoxic to tumor cells and are promising candidates to be used in chemotherapy against cancer. Herein we elaborate upon the major forms of dietary selenium compounds, their metabolic pathways, and their antioxidant and pro-oxidant potentials with emphasis on cytotoxic mechanisms. Relative cytotoxicity of inorganic selenite and organic selenocystine compounds to different cancer cells are presented as evidence to our perspective. Furthermore, new novel classes of selenium compounds specifically designed to target tumor cells are presented and the potential of selenium in modern oncology is extensively discussed.

  15. PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis.

    Science.gov (United States)

    Samanta, Debangshu; Park, Youngrok; Andrabi, Shaida A; Shelton, Laura M; Gilkes, Daniele M; Semenza, Gregg L

    2016-08-01

    Intratumoral hypoxia stimulates enrichment of breast cancer stem cells (BCSC), which are critical for metastasis and patient mortality. Here we report a metabolic adaptation that is required for hypoxia-induced BCSC enrichment and metastasis. Hypoxia-inducible factors coordinately regulate expression of genes encoding phosphoglycerate dehydrogenase (PHGDH) and five downstream enzymes in the serine synthesis pathway and mitochondrial one-carbon (folate) cycle. RNAi-mediated silencing of PHGDH expression in both estrogen receptor-positive and negative breast cancer cells led to decreased NADPH levels, disturbed mitochondrial redox homeostasis, and increased apoptosis, which abrogated BCSC enrichment under hypoxic conditions. PHGDH-deficient cells exhibited increased oxidant levels and apoptosis, as well as loss of BCSC enrichment, in response to treatment with carboplatin or doxorubicin. PHGDH-deficient cells were relatively weakly tumorigenic and tumors that did form were deficient in BCSCs, abolishing metastatic capacity. Our findings highlight a role for PHGDH in the formation of secondary (recurrent or metastatic) tumors, with potential implications for therapeutic targeting of advanced cancers. Cancer Res; 76(15); 4430-42. ©2016 AACR. PMID:27280394

  16. Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-kB signaling

    Science.gov (United States)

    Cancer cells have an efficient antioxidant system to counteract their increased generation of ROS. However, whether this ability to survive high levels of ROS has an important role in the growth and metastasis of tumors is not well understood. Here, we demonstrate that the redox protein thioredoxin-...

  17. Redox Signaling and Bioenergetics Influence Lung Cancer Cell Line Sensitivity to the Isoflavone ME-344.

    Science.gov (United States)

    Manevich, Yefim; Reyes, Leticia; Britten, Carolyn D; Townsend, Danyelle M; Tew, Kenneth D

    2016-08-01

    ME-344 [(3R,4S)-3,4-bis(4-hydroxyphenyl)-8-methyl-3,4-dihydro-2H-chromen-7-ol] is a second-generation derivative natural product isoflavone presently under clinical development. ME-344 effects were compared in lung cancer cell lines that are either intrinsically sensitive or resistant to the drug and in primary immortalized human lung embryonic fibroblasts (IHLEF). Cytotoxicity at low micromolar concentrations occurred only in sensitive cell lines, causing redox stress, decreased mitochondrial ATP production, and subsequent disruption of mitochondrial function. In a dose-dependent manner the drug caused instantaneous and pronounced inhibition of oxygen consumption rates (OCR) in drug-sensitive cells (quantitatively significantly less in drug-resistant cells). This was consistent with targeting of mitochondria by ME-344, with specific effects on the respiratory chain (resistance correlated with higher glycolytic indexes). OCR inhibition did not occur in primary IHLEF. ME-344 increased extracellular acidification rates in drug-resistant cells (significantly less in drug-sensitive cells), implying that ME-344 targets mitochondrial proton pumps. Only in drug-sensitive cells did ME-344 dose-dependently increase the intracellular generation of reactive oxygen species and cause oxidation of total (mainly glutathione) and protein thiols and the concomitant immediate increases in NADPH levels. We conclude that ME-344 causes complex, redox-specific, and mitochondria-targeted effects in lung cancer cells, which differ in extent from normal cells, correlate with drug sensitivity, and provide indications of a beneficial in vitro therapeutic index. PMID:27255112

  18. Postquantum Steering

    Science.gov (United States)

    Sainz, Ana Belén; Brunner, Nicolas; Cavalcanti, Daniel; Skrzypczyk, Paul; Vértesi, Tamás

    2015-11-01

    The discovery of postquantum nonlocality, i.e., the existence of nonlocal correlations that are stronger than any quantum correlations but nevertheless consistent with the no-signaling principle, has deepened our understanding of the foundations of quantum theory. In this work, we investigate whether the phenomenon of Einstein-Podolsky-Rosen steering, a different form of quantum nonlocality, can also be generalized beyond quantum theory. While post-quantum steering does not exist in the bipartite case, we prove its existence in the case of three observers. Importantly, we show that postquantum steering is a genuinely new phenomenon, fundamentally different from postquantum nonlocality. Our results provide new insight into the nonlocal correlations of multipartite quantum systems.

  19. A role for PP1/NIPP1 in steering migration of human cancer cells.

    Directory of Open Access Journals (Sweden)

    Cristina Martin-Granados

    Full Text Available Electrical gradients are present in many developing and regenerating tissues and around tumours. Mimicking endogenous electric fields in vitro has profound effects on the behaviour of many cell types. Intriguingly, specific cell types migrate cathodally, others anodally and some polarise with their long axis perpendicular to the electric vector. These striking phenomena are likely to have in vivo relevance since one of the determining factors during cancer metastasis is the ability to switch between attractive and repulsive migration in response to extracellular guidance stimuli. We present evidence that the cervical cancer cell line HeLa migrates cathodally in a direct current electric field of physiological intensity, while the strongly metastatic prostate cancer cell line PC-3-M migrates anodally. Notably, genetic disruption of protein serine/threonine phosphatase-1 (PP1 and its regulator NIPP1 decrease directional migration in these cell lines. Conversely, the inducible expression of NIPP1 switched the directional response of HeLa cells from cathodal to slightly anodal in a PP1-dependent manner. Remarkably, induction of a hyperactive PP1/NIPP1 holoenzyme, further shifted directional migration towards the anode. We show that PP1 association with NIPP1 upregulates signalling by the GTPase Cdc42 and demonstrate that pharmacological inhibition of Cdc42 in cells overexpressing NIPP1 recovered cathodal migration. Taken together, we provide the first evidence for regulation of directional cell migration by NIPP1. In addition, we identify PP1/NIPP1 as a novel molecular compass that controls directed cell migration via upregulation of Cdc42 signalling and suggest a way by which PP1/NIPP1 may contribute to the migratory properties of cancer cells.

  20. A Role for PP1/NIPP1 in Steering Migration of Human Cancer Cells

    OpenAIRE

    Martin-Granados, Cristina; Prescott, Alan R.; Van Dessel, Nele; Van Eynde, Aleyde; Arocena, Miguel; Klaska, Izabela P.; Görnemann, Janina; Beullens, Monique; Bollen, Mathieu; Forrester, John V.; McCaig, Colin D.

    2012-01-01

    Electrical gradients are present in many developing and regenerating tissues and around tumours. Mimicking endogenous electric fields in vitro has profound effects on the behaviour of many cell types. Intriguingly, specific cell types migrate cathodally, others anodally and some polarise with their long axis perpendicular to the electric vector. These striking phenomena are likely to have in vivo relevance since one of the determining factors during cancer metastasis is the ability to switch ...

  1. Oxidative stress, redox signaling pathways, and autophagy in cachectic muscles of male patients with advanced COPD and lung cancer.

    Science.gov (United States)

    Puig-Vilanova, Ester; Rodriguez, Diego A; Lloreta, Josep; Ausin, Pilar; Pascual-Guardia, Sergio; Broquetas, Joan; Roca, Josep; Gea, Joaquim; Barreiro, Esther

    2015-02-01

    Muscle dysfunction and wasting are predictors of mortality in advanced COPD and malignancies. Redox imbalance and enhanced protein catabolism are underlying mechanisms in COPD. We hypothesized that the expression profile of several biological markers share similarities in patients with cachexia associated with either COPD or lung cancer (LC). In vastus lateralis of cachectic patients with either LC (n=10) or advanced COPD (n=16) and healthy controls (n=10), markers of redox balance, inflammation, proteolysis, autophagy, signaling pathways, mitochondrial function, muscle structure, and sarcomere damage were measured using laboratory and light and electron microscopy techniques. Systemic redox balance and inflammation were also determined. All subjects were clinically evaluated. Compared to controls, in both cachectic groups of patients, a similar expression profile of different biological markers was observed in their muscles: increased levels of muscle protein oxidation and ubiquitination (p<0.05, both), which positively correlated (r=0.888), redox-sensitive signaling pathways (NF-κB and FoxO) were activated (p<0.05, all), fast-twitch fiber sizes were atrophied, muscle structural abnormalities and sarcomere disruptions were significantly greater (p<0.05, both). Structural and functional protein levels were lower in muscles of both cachectic patient groups than in controls (p<0.05, all). However, levels of autophagy markers including ultrastructural autophagosome counts were increased only in muscles of cachectic COPD patients (p<0.05). Systemic oxidative stress and inflammation levels were also increased in both patient groups compared to controls (p<0.005, both). Oxidative stress and redox-sensitive signaling pathways are likely to contribute to the etiology of muscle wasting and sarcomere disruption in patients with respiratory cachexia: LC and COPD. PMID:25464271

  2. The redox state of cytochrome c modulates resistance to methotrexate in human MCF7 breast cancer cells.

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    Susana Barros

    Full Text Available BACKGROUND: Methotrexate is a chemotherapeutic agent used to treat a variety of cancers. However, the occurrence of resistance limits its effectiveness. Cytochrome c in its reduced state is less capable of triggering the apoptotic cascade. Thus, we set up to study the relationship among redox state of cytochrome c, apoptosis and the development of resistance to methotrexate in MCF7 human breast cancer cells. RESULTS: Cell incubation with cytochrome c-reducing agents, such as tetramethylphenylenediamine, ascorbate or reduced glutathione, decreased the mortality and apoptosis triggered by methotrexate. Conversely, depletion of glutathione increased the apoptotic action of methotrexate, showing an involvement of cytochrome c redox state in methotrexate-induced apoptosis. Methotrexate-resistant MCF7 cells showed increased levels of endogenous reduced glutathione and a higher capability to reduce exogenous cytochrome c. Using functional genomics we detected the overexpression of GSTM1 and GSTM4 in methotrexate-resistant MCF7 breast cancer cells, and determined that methotrexate was susceptible of glutathionylation by GSTs. The inhibition of these GSTM isoforms caused an increase in methotrexate cytotoxicity in sensitive and resistant cells. CONCLUSIONS: We conclude that overexpression of specific GSTMs, GSTM1 and GSTM4, together with increased endogenous reduced glutathione levels help to maintain a more reduced state of cytochrome c which, in turn, would decrease apoptosis, thus contributing to methotrexate resistance in human MCF7 breast cancer cells.

  3. Unravelling ``off-target'' effects of redox-active polymers and polymer multilayered capsules in prostate cancer cells

    Science.gov (United States)

    Beretta, Giovanni L.; Folini, Marco; Cavalieri, Francesca; Yan, Yan; Fresch, Enrico; Kaliappan, Subramanian; Hasenöhrl, Christoph; Richardson, Joseph J.; Tinelli, Stella; Fery, Andreas; Caruso, Frank; Zaffaroni, Nadia

    2015-03-01

    Redox-active polymers and carriers are oxidizing nanoagents that can potentially trigger intracellular off-target effects. In the present study, we investigated the occurrence of off-target effects in prostate cancer cells following exposure to redox-active polymer and thin multilayer capsules with different chemical properties. We show that, depending on the intracellular antioxidant capacity, thiol-functionalized poly(methacrylic acid), PMASH triggers cell defense responses/perturbations that result in off-target effects (i.e., induction of autophagy and down-regulation of survivin). Importantly, the conversion of the carboxyl groups of PMASH into the neutral amides of poly(hydroxypropylmetacrylamide) (pHPMASH) nullified the off-target effects and cytotoxicity in tested cell lines. This suggests that the simultaneous action of carboxyl and disulfide groups in PMASH polymer or capsules may play a role in mediating the intracellular off-target effects. Our work provides evidence that the rational design of redox-active carriers for therapeutic-related application should be guided by a careful investigation on potential disturbance of the cellular machineries related to the carrier association.Redox-active polymers and carriers are oxidizing nanoagents that can potentially trigger intracellular off-target effects. In the present study, we investigated the occurrence of off-target effects in prostate cancer cells following exposure to redox-active polymer and thin multilayer capsules with different chemical properties. We show that, depending on the intracellular antioxidant capacity, thiol-functionalized poly(methacrylic acid), PMASH triggers cell defense responses/perturbations that result in off-target effects (i.e., induction of autophagy and down-regulation of survivin). Importantly, the conversion of the carboxyl groups of PMASH into the neutral amides of poly(hydroxypropylmetacrylamide) (pHPMASH) nullified the off-target effects and cytotoxicity in tested cell

  4. Mechanistic studies of cancer cell mitochondria- and NQO1-mediated redox activation of beta-lapachone, a potentially novel anticancer agent

    International Nuclear Information System (INIS)

    Beta-lapachone (beta-Lp) derived from the Lapacho tree is a potentially novel anticancer agent currently under clinical trials. Previous studies suggested that redox activation of beta-Lp catalyzed by NAD(P)H:quinone oxidoreductase 1 (NQO1) accounted for its killing of cancer cells. However, the exact mechanisms of this effect remain largely unknown. Using chemiluminescence and electron paramagnetic resonance (EPR) spin-trapping techniques, this study for the first time demonstrated the real-time formation of ROS in the redox activation of beta-lapachone from cancer cells mediated by mitochondria and NQO1 in melanoma B16–F10 and hepatocellular carcinoma HepG2 cancer cells. ES936, a highly selective NQO1 inhibitor, and rotenone, a selective inhibitor of mitochondrial electron transport chain (METC) complex I were found to significantly block beta-Lp meditated redox activation in B16–F10 cells. In HepG2 cells ES936 inhibited beta-Lp-mediated oxygen radical formation by ∼ 80% while rotenone exerted no significant effect. These results revealed the differential contribution of METC and NQO1 to beta-lapachone-induced ROS formation and cancer cell killing. In melanoma B16–F10 cells that do not express high NQO1 activity, both NOQ1 and METC play a critical role in beta-Lp redox activation. In contrast, in hepatocellular carcinoma HepG2 cells expressing extremely high NQO1 activity, redox activation of beta-Lp is primarily mediated by NQO1 (METC plays a minor role). These findings will contribute to our understanding of how cancer cells are selectively killed by beta-lapachone and increase our ability to devise strategies to enhance the anticancer efficacy of this potentially novel drug while minimizing its possible adverse effects on normal cells. - Highlights: • Both isolated mitochondria and purified NQO1 are able to generate ROS by beta-Lp. • The differential roles of mitochondria and NQO1 in mediating redox activation of beta-Lp • In cancer cells with

  5. Mechanistic studies of cancer cell mitochondria- and NQO1-mediated redox activation of beta-lapachone, a potentially novel anticancer agent

    Energy Technology Data Exchange (ETDEWEB)

    Li, Jason Z. [Virginia Tech CRC, Blacksburg, VA (United States); Ke, Yuebin [Shenzhen Center for Disease Control and Prevention, Shenzhen 518055 (China); Misra, Hara P. [Virginia Tech CRC, Blacksburg, VA (United States); Trush, Michael A. [Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (United States); Li, Y. Robert [Campbell University School of Osteopathic Medicine, Buies Creek, NC (United States); Virginia Tech-Wake Forest University SBES, Blacksburg, VA (United States); Department of Biology, University of North Carolina at Greensboro, NC (United States); Zhu, Hong, E-mail: zhu@campbell.edu [Campbell University School of Osteopathic Medicine, Buies Creek, NC (United States); Jia, Zhenquan, E-mail: z_jia@uncg.edu [Department of Biology, University of North Carolina at Greensboro, NC (United States)

    2014-12-15

    Beta-lapachone (beta-Lp) derived from the Lapacho tree is a potentially novel anticancer agent currently under clinical trials. Previous studies suggested that redox activation of beta-Lp catalyzed by NAD(P)H:quinone oxidoreductase 1 (NQO1) accounted for its killing of cancer cells. However, the exact mechanisms of this effect remain largely unknown. Using chemiluminescence and electron paramagnetic resonance (EPR) spin-trapping techniques, this study for the first time demonstrated the real-time formation of ROS in the redox activation of beta-lapachone from cancer cells mediated by mitochondria and NQO1 in melanoma B16–F10 and hepatocellular carcinoma HepG2 cancer cells. ES936, a highly selective NQO1 inhibitor, and rotenone, a selective inhibitor of mitochondrial electron transport chain (METC) complex I were found to significantly block beta-Lp meditated redox activation in B16–F10 cells. In HepG2 cells ES936 inhibited beta-Lp-mediated oxygen radical formation by ∼ 80% while rotenone exerted no significant effect. These results revealed the differential contribution of METC and NQO1 to beta-lapachone-induced ROS formation and cancer cell killing. In melanoma B16–F10 cells that do not express high NQO1 activity, both NOQ1 and METC play a critical role in beta-Lp redox activation. In contrast, in hepatocellular carcinoma HepG2 cells expressing extremely high NQO1 activity, redox activation of beta-Lp is primarily mediated by NQO1 (METC plays a minor role). These findings will contribute to our understanding of how cancer cells are selectively killed by beta-lapachone and increase our ability to devise strategies to enhance the anticancer efficacy of this potentially novel drug while minimizing its possible adverse effects on normal cells. - Highlights: • Both isolated mitochondria and purified NQO1 are able to generate ROS by beta-Lp. • The differential roles of mitochondria and NQO1 in mediating redox activation of beta-Lp • In cancer cells with

  6. Assessment of the Tumor Redox Status in Head and Neck Cancer by 62Cu-ATSM PET

    Science.gov (United States)

    Tsujikawa, Tetsuya; Asahi, Satoko; Oh, Myungmi; Sato, Yoshitaka; Narita, Norihiko; Makino, Akira; Mori, Tetsuya; Kiyono, Yasushi; Tsuchida, Tatsuro; Kimura, Hirohiko; Fujieda, Shigeharu; Okazawa, Hidehiko

    2016-01-01

    Purpose Tumor redox is an important factor for cancer progression, resistance to treatments, and a poor prognosis. The aim of the present study was to define tumor redox (over-reduction) using 62Cu-diacetyl-bis(N4-methylthiosemicarbazone) (62Cu-ATSM) PET and compare its prognostic potential in head and neck cancer (HNC) with that of 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG). Methods Thirty HNC patients (stage II–IV) underwent pretreatment 62Cu-ATSM and 18F-FDG PET scans. Maximum standardized uptake values (SUVATSM and SUVFDG) and tumor-to-muscle activity concentration ratios (TMRATSM and TMRFDG) were measured. Reductive-tumor-volume (RTV) was then determined at four thresholds (40%, 50%, 60%, and 70% SUVATSM), and total-lesion-reduction (TLR) was calculated as the product of the mean SUV and RTV for 62Cu-ATSM. In 18F-FDG, metabolic-tumor-volume (MTV) and total-lesion-glycolysis (TLG) were obtained at a threshold of 40%. A ROC analysis was performed to determine % thresholds for RTV and TLR showing the best predictive performance, and these were then used to determine the optimal cut-off values to stratify patients for each parameter. Progression-free-survival (PFS) and cause-specific-survival (CSS) were evaluated by the Kaplan-Meier method. Results The means ± standard deviations of PFS and CSS periods were 16.4±13.4 and 19.2±12.4 months, respectively. A ROC analysis determined that the 70% SUVATSM threshold for RTV and TLR was the best for predicting disease progression and cancer death. Optimal cut-offs for each index were SUVATSM = 3.6, SUVFDG = 7.9, TMRATSM = 3.2, TMRFDG = 5.6, RTV = 2.9, MTV = 8.1, TLR = 14.0, and TLG = 36.5. When the cut-offs for TMRATSM and TLR were set as described above in 62Cu-ATSM PET, patients with higher TMRATSM (p = 0.03) and greater TLR (p = 0.02) showed significantly worse PFS, while patients with greater TLR had significantly worse CSS (p = 0.02). Only MTV in 18F-FDG PET predicted differences in PSF and CSS (p = 0.03 and p = 0

  7. Natural dietary anti-cancer chemopreventive compounds: redox-mediated differential signaling mechanisms in cytoprotection of normal cellsversus cytotoxicity in tumor cells

    Institute of Scientific and Technical Information of China (English)

    Sujit NAIR; Wenge LI; Ah-Ng Tony KONG

    2007-01-01

    Many dietary phytochemicals exhibit health-beneficial effects including preven-tion of diseases such as cancer, as well as neurological, cardiovascular, inflam-matory, and metabolic diseases. Evolutionarily, herbivorous and omnivorous animals have been ingesting plants. This interaction between "animal-plant"ecosystems has resulted in an elaborate system of detoxification and defense mechanisms evolved by animals including humans. Mammalian cells, including human cells, respond to these dietary phytochemicals by "non-classical receptor sensing" mechanisms of electrophilic chemical-stress typified by "thiol-modu-lated" cellular signaling events primarily leading to the gene expression of phar-macologically beneficial effects, but sometimes unwanted cytotoxicity also. Our laboratory has been studying two groups of dietary phytochemical cancer-chemopreventive compounds (isothiocyanates and polyphenols), which are effective in chemical-induced, as well as genetically-induced, animal carcinogen-esis models. These compounds typically generate "cellular stress" and modulate gene expression of phase Ⅱ detoxifying/antioxidant enzymes. Electrophiles, reac-tive oxygen species, and reactive nitrogen species are known to act as second messengers in the modulation of many cellular signaling pathways leading to gene expression changes and pharmacological responses. Redox-sensitive tran-scription factors such as nuclear factor-E2-related factor 2 (Nrf2), AP-1, NF-κB, to cite a few examples, sense and transduce changes in the cellular redox status and modulate gene expression responses to oxidative and electrophilic stresses, pre-sumably via sulfhydryl modification of critical cysteine residues found on these proteins and/or other upstream redox-sensitive molecular targets. In the current review, we will explore dietary cancer chemopreventive phytochemicals, discuss the link between oxidative/electrophilic stresses and the redox circuitry, and con-sider different redox

  8. Redox-directed cancer therapeutics: Taurolidine and Piperlongumine as broadly effective antineoplastic agents (review).

    Science.gov (United States)

    Möhler, Hanns; Pfirrmann, Rolf W; Frei, Karl

    2014-10-01

    Targeting the oxygen stress response pathway is considered a promising strategy to exert antineoplastic activity in a broad spectrum of tumor types. Supporting this view, we summarize the mechanism of action of Taurolidine and Piperlongumine, two antineoplastic agents with strikingly broad tumor selectivity. Taurolidine enhances the oxidative stress (ROS) selectively in tumor cells. Its cytotoxicity for various tumor cells in vitro and in vivo, which includes tumor stem cells, is based on the induction of programmed cell death, largely via apoptosis but also necroptosis and autophagy. The redox-directed mechanism of action of Taurolidine is apparent from the finding that reducing agents e.g., N-acetylcysteine or glutathione impair its cytotoxicity, while its effectiveness is enhanced by agents which inhibit the cellular anti‑oxidant capacity. A similar redox-directed antineoplastic action is shown by Piperlongumine, a recently described experimental drug of plant origin. Taurolidine is particularly advantageous in surgical oncology as this taurine-derivative can be applied perioperatively or systemically with good tolerability as shown in initial clinical applications. PMID:25175943

  9. Nrf2, the master redox switch : The Achilles' heel of ovarian cancer?

    NARCIS (Netherlands)

    van der Wijst, Monique G. P.; Brown, Robert; Rots, Marianne G.

    2014-01-01

    Ovarian cancer is the most lethal gynecological tumor type in the world due to late stage detection, and resistance to chemotherapy. Therefore, alternative additional therapies are required. The etiology of ovarian cancer remains largely unknown, but risk factors point toward an important role for o

  10. Universal Steering Criteria

    Science.gov (United States)

    Zhu, Huangjun; Hayashi, Masahito; Chen, Lin

    2016-02-01

    We propose a general framework for constructing universal steering criteria that are applicable to arbitrary bipartite states and measurement settings of the steering party. The same framework is also useful for studying the joint measurement problem. Based on the data-processing inequality for an extended Rényi relative entropy, we then introduce a family of steering inequalities, which detect steering much more efficiently than those inequalities known before. As illustrations, we show unbounded violation of a steering inequality for assemblages constructed from mutually unbiased bases and establish an interesting connection between maximally steerable assemblages and complete sets of mutually unbiased bases. We also provide a single steering inequality that can detect all bipartite pure states of full Schmidt rank. In the course of study, we generalize a number of results intimately connected to data-processing inequalities, which are of independent interest.

  11. A redox-responsive mesoporous silica nanoparticle capped with amphiphilic peptides by self-assembly for cancer targeting drug delivery

    Science.gov (United States)

    Xiao, Dong; Jia, Hui-Zhen; Ma, Ning; Zhuo, Ren-Xi; Zhang, Xian-Zheng

    2015-05-01

    A redox-responsive mesoporous silica nanoparticle (RRMSN) was developed as a drug nanocarrier by noncovalent functionalization of MSNs with amphiphilic peptides containing the RGD ligand. The alkyl chain stearic acid (C18) with a thiol terminal group was anchored on the surface of MSNs via a disulfide bond, and the amphiphilic peptide (AP) C18-DSDSDSDSRGDS was coated by self-assembly through hydrophobic interactions between the octadecyl groups of MSNs and alkyl chains of AP, which played the role of a gatekeeper collectively. In vitro drug release profiles demonstrated that the anticancer drug (DOX) could be entrapped with nearly no leakage in the absence of dithiothreitol (DTT) or glutathione (GSH). With the addition of DTT or GSH, the entrapped drug released quickly due to the cleavage of the disulfide bond. It was found that after the internalization of MSNs by cancer cells via the receptor-mediated endocytosis, the surface amphiphilic peptides and alkyl chain of RRMSN/DOX were removed to induce rapid drug release intracellularly after the cleavage of the disulfide bond, triggered by GSH secreted in cancer cells. This novel intelligent RRMSN/DOX drug delivery system using self-assembly of amphiphilic peptides around the MSNs provides a facile, but effective strategy for the design and development of smart drug delivery for cancer therapy.A redox-responsive mesoporous silica nanoparticle (RRMSN) was developed as a drug nanocarrier by noncovalent functionalization of MSNs with amphiphilic peptides containing the RGD ligand. The alkyl chain stearic acid (C18) with a thiol terminal group was anchored on the surface of MSNs via a disulfide bond, and the amphiphilic peptide (AP) C18-DSDSDSDSRGDS was coated by self-assembly through hydrophobic interactions between the octadecyl groups of MSNs and alkyl chains of AP, which played the role of a gatekeeper collectively. In vitro drug release profiles demonstrated that the anticancer drug (DOX) could be entrapped with

  12. A novel class of mitochondria-targeted soft electrophiles modifies mitochondrial proteins and inhibits mitochondrial metabolism in breast cancer cells through redox mechanisms.

    Directory of Open Access Journals (Sweden)

    Praveen K Vayalil

    Full Text Available Despite advances in screening and treatment over the past several years, breast cancer remains a leading cause of cancer-related death among women in the United States. A major goal in breast cancer treatment is to develop safe and clinically useful therapeutic agents that will prevent the recurrence of breast cancers after front-line therapeutics have failed. Ideally, these agents would have relatively low toxicity against normal cells, and will specifically inhibit the growth and proliferation of cancer cells. Our group and others have previously demonstrated that breast cancer cells exhibit increased mitochondrial oxygen consumption compared with non-tumorigenic breast epithelial cells. This suggests that it may be possible to deliver redox active compounds to the mitochondria to selectively inhibit cancer cell metabolism. To demonstrate proof-of-principle, a series of mitochondria-targeted soft electrophiles (MTSEs has been designed which selectively accumulate within the mitochondria of highly energetic breast cancer cells and modify mitochondrial proteins. A prototype MTSE, IBTP, significantly inhibits mitochondrial oxidative phosphorylation, resulting in decreased breast cancer cell proliferation, cell attachment, and migration in vitro. These results suggest MTSEs may represent a novel class of anti-cancer agents that prevent cancer cell growth by modification of specific mitochondrial proteins.

  13. Hyaluronic acid functional amphipathic and redox-responsive polymer particles for the co-delivery of doxorubicin and cyclopamine to eradicate breast cancer cells and cancer stem cells

    Science.gov (United States)

    Hu, Kelei; Zhou, Huige; Liu, Ying; Liu, Zhu; Liu, Jing; Tang, Jinglong; Li, Jiayang; Zhang, Jiakun; Sheng, Wang; Zhao, Yuliang; Wu, Yan; Chen, Chunying

    2015-04-01

    Cancer stem cells (CSCs) have the ability to transform into bulk cancer cells, to promote tumor growth and establish tumor metastasis. To effectively inhibit tumor growth and prevent metastasis, treatments with conventional chemotherapy drugs should be combined with CSC targeted drugs. In this study, we describe the synthesis and characterization of a new amphiphilic polymer, hyaluronic acid-cystamine-polylactic-co-glycolic acid (HA-SS-PLGA), composed of a hydrophobic PLGA head and a hydrophilic HA segment linked by a bioreducible disulfide bond. With a double emulsion method, a nano delivery system was constructed to deliver doxorubicin (DOX) and cyclopamine (CYC, a primary inhibitor of the hedgehog signaling pathway of CSCs) to both a CD44-overexpressing breast CSC subpopulation and bulk breast cancer cells and allow an on-demand release. The resulting drug-loaded NPs exhibited a redox-responsive drug release profile. Dual drug-loaded particles potently diminished the number and size of tumorspheres and HA showed a targeting effect towards breast CSCs. In vivo combination therapy further demonstrated a remarkable synergistic anti-tumor effect and prolonged survival compared to mono-therapy using the orthotopic mammary fat pad tumor growth model. The co-delivery of drug and the CSC specific inhibitor towards targeted cancer chemotherapeutics provides an insight into anticancer strategy with facile control and high efficacy.Cancer stem cells (CSCs) have the ability to transform into bulk cancer cells, to promote tumor growth and establish tumor metastasis. To effectively inhibit tumor growth and prevent metastasis, treatments with conventional chemotherapy drugs should be combined with CSC targeted drugs. In this study, we describe the synthesis and characterization of a new amphiphilic polymer, hyaluronic acid-cystamine-polylactic-co-glycolic acid (HA-SS-PLGA), composed of a hydrophobic PLGA head and a hydrophilic HA segment linked by a bioreducible disulfide bond

  14. Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells.

    Directory of Open Access Journals (Sweden)

    Kankan Wang

    Full Text Available BACKGROUND: Pharmacological intervention of redox balance in cancer cells often results in oxidative stress-mediated apoptosis, attracting much attention for the development of a new generation of targeted therapy in cancer. However, little is known about mechanisms underlying the conversion from oxidative signaling to downstream activities leading cells to death. METHODOLOGY/PRINCIPAL FINDINGS: We here report a systematic detection of transcriptome changes in response to oxidative signals generated in leukemia cells upon fenretinide treatment, implicating the occurrence of numerous stress-responsive events during the fenretinide induced apoptosis, such as redox response, endoplasmic reticulum stress/unfolded protein response, translational repression and proteasome activation. Moreover, the configuration of these relevant events is primarily orchestrated by stress responsive transcription factors, as typically highlighted by NF-E2-related factor-2 (NRF2 and heat shock factor 1 (HSF1. Several lines of evidence suggest that the coordinated regulation of these transcription factors and thus their downstream genes are involved in converting oxidative signaling into downstream stress-responsive events regulating pro-apoptotic and apoptotic activities at the temporal and spatial levels, typifying oxidative stress-mediated programmed death rather than survival in cancer cells. CONCLUSIONS/SIGNIFICANCE: This study provides a roadmap for understanding oxidative stress-mediated apoptosis in cancer cells, which may be further developed into more sophisticated therapeutic protocols, as implicated by synergistic induction of cell apoptosis using proteasome inhibitors with fenretinide.

  15. Design of Pneumatic Collapsible Steering

    Directory of Open Access Journals (Sweden)

    Anish Nair

    2013-08-01

    Full Text Available The steering wheel is the important cause of fatal injury for drivers in frontal collision. When frontal collision occurs, due to the kinetic energy of driver or occupant body, it moves forward against steering wheel and wind shield. Actually in a frontal collision forces will be first transmitted through driver’s feet which act as fulcrum so the body will rotate about it. For the taller driver steering works as fulcrum. Driver head & chest hit the steering or windshield which may cause severe injury or death. Considering the injury potential of steering wheel we are presenting a new idea Pneumatic Collapsible Steering Column (PCS.

  16. 49 CFR 570.60 - Steering system.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Steering system. 570.60 Section 570.60... 10,000 Pounds § 570.60 Steering system. (a) System play. Lash or free play in the steering system... excessive lash or free play in the steering system. Table 2. Steering Wheel Free Play Values Steering...

  17. Electrical steering of vehicles

    DEFF Research Database (Denmark)

    Blanke, Mogens; Thomsen, Jesper Sandberg

    2006-01-01

    solutions and still meet strict requirements to functional safety. The paper applies graph-based analysis of functional system structure to find a novel fault-tolerant architecture for an electrical steering where a dedicated AC-motor design and cheap voltage measurements ensure ability to detect all...

  18. Electromagnetic tracking and steering for catheter navigation

    OpenAIRE

    O'Donoghue, Kilian

    2014-01-01

    This thesis explores the use of electromagnetics for both steering and tracking of medical instruments in minimally invasive surgeries. The end application is virtual navigation of the lung for biopsy of early stage cancer nodules. Navigation to the peripheral regions of the lung is difficult due to physical dimensions of the bronchi and current methods have low successes rates for accurate diagnosis. Firstly, the potential use of DC magnetic fields for the actuation of catheter devices with ...

  19. Steering Your Mysterious Mind

    DEFF Research Database (Denmark)

    Prasad, Ramjee

    Steering the Mysterious Mind, describes a unique, novel concept for a way to gain control of your mind. The five basic elements of human life, that is; Creativity, Content­ment, Confidence, Calmness, and Concentration (C5) have been introduced in my previous book Unlock Your Personalization...... well-being is key for happy and stress free life. Mind has enormous energy. Everyone has access to tre­mendous mental energies; what matters is being aware of this and to work on concentrating your energy into creative work. To achieve mental strength, C5 is a su­preme powerful exercise for the mind....... Compare it with going to the gym where you work on the physical body. In the same way as with arms and legs, the mind is a mus­cle which you exercise through C5 practice. Steering the mind on your personal goal will help you to be creative....

  20. Laser beam steering device

    Science.gov (United States)

    Motamedi, M. E.; Andrews, A. P.; Gunning, W. J.

    1993-01-01

    Agile beam steering is a critical requirement for airborne and space based LIDAR and optical communication systems. Design and test results are presented for a compact beam steering device with low inertia which functions by dithering two complementary (positive and negative) binary optic microlens arrays relative to each other in directions orthogonal to the direction of light propagation. The miniaturized system has been demonstrated at scan frequencies as high as 300 Hz, generating a 13 x 13 spot array with a total field of view of 2.4 degrees. The design is readily extendable to a 9.5 degree field of view and a 52 x 52 scan pattern. The system is compact - less than 2 in. on a side. Further size reductions are anticipated.

  1. Beam steering system

    Science.gov (United States)

    Bowhill, S. A.; Merewether, K. O.

    1986-01-01

    A simple technique for steering the beam of a multimodule phased array MST (mesosphere, stratosphere, troposphere) radar antenna is described. It is desirable to be able to point the antenna in multiple directions, so as to derive all components of the horizontal velocity. This was done on an experimental basis by adding parallel wire line to the feed and achieving a southward tilt of the antenna. It is proved possible to steer the beam through most of the available range without adversely affecting the VSWR seen from the transmitter. Calibrating the antenna direction can be accomplished by observing radio sources, though there are an inadequate number to cover all directions. For various assumed values of the aspect sensitivity in dB/deg, and the calculated antenna pattern, it is possible to calculate the effective pointing angle of the antenna, defined as that angle which would give an identical location for the centroid of the power spectrum if aspect sensitivity were absent. Using averaged apparent steering directions, eastward and northward winds were calculated for special radar runs simultaneous with 14 balloon launches at Peoria and results are presented.

  2. Loophole-free quantum steering

    CERN Document Server

    Wittmann, Bernhard; Steinlechner, Fabian; Langford, Nathan K; Brunner, Nicolas; Wiseman, Howard; Ursin, Rupert; Zeilinger, Anton

    2011-01-01

    Tests of the predictions of quantum mechanics for entangled systems have provided increasing evidence against local realistic theories 1-6. However, there still remains the crucial challenge of simultaneously closing all major loopholes - the locality, freedom-of-choice, and detection loopholes - in a single experiment. An important sub-class of local realistic theories can be tested with the concept of "steering". The term steering was introduced by Schr\\"odinger in 1935 for the fact that entanglement would seem to allow an experimenter to remotely steer the state of a distant system 7. Einstein called this "spooky action at a distance" 8. Steering has recently been rigorously formulated as a quantum information task opening it up to new experimental tests 9-11. Here, we present the first loophole-free demonstration of steering by violating three-setting quadratic steering inequality, tested with polarization entangled photons shared between two distant laboratories. Our experiment demonstrates this effect w...

  3. Quantum coherence of steered states.

    Science.gov (United States)

    Hu, Xueyuan; Milne, Antony; Zhang, Boyang; Fan, Heng

    2016-01-01

    Lying at the heart of quantum mechanics, coherence has recently been studied as a key resource in quantum information theory. Quantum steering, a fundamental notion originally considered by Schödinger, has also recently received much attention. When Alice and Bob share a correlated quantum system, Alice can perform a local measurement to 'steer' Bob's reduced state. We introduce the maximal steered coherence as a measure describing the extent to which steering can remotely create coherence; more precisely, we find the maximal coherence of Bob's steered state in the eigenbasis of his original reduced state, where maximization is performed over all positive-operator valued measurements for Alice. We prove that maximal steered coherence vanishes for quantum-classical states whilst reaching a maximum for pure entangled states with full Schmidt rank. Although invariant under local unitary operations, maximal steered coherence may be increased when Bob performs a channel. For a two-qubit state we find that Bob's channel can increase maximal steered coherence if and only if it is neither unital nor semi-classical, which coincides with the condition for increasing discord. Our results show that the power of steering for coherence generation, though related to discord, is distinct from existing measures of quantum correlation. PMID:26781214

  4. Design of Pneumatic Collapsible Steering

    OpenAIRE

    Anish Nair; Dhanesh Chatta; Rince Wins

    2013-01-01

    The steering wheel is the important cause of fatal injury for drivers in frontal collision. When frontal collision occurs, due to the kinetic energy of driver or occupant body, it moves forward against steering wheel and wind shield. Actually in a frontal collision forces will be first transmitted through driver’s feet which act as fulcrum so the body will rotate about it. For the taller driver steering works as fulcrum. Driver head & chest hit the steering or windshield which may cause sever...

  5. Steering Maps and Their Application to Dimension-Bounded Steering.

    Science.gov (United States)

    Moroder, Tobias; Gittsovich, Oleg; Huber, Marcus; Uola, Roope; Gühne, Otfried

    2016-03-01

    The existence of quantum correlations that allow one party to steer the quantum state of another party is a counterintuitive quantum effect that was described at the beginning of the past century. Steering occurs if entanglement can be proven even though the description of the measurements on one party is not known, while the other side is characterized. We introduce the concept of steering maps, which allow us to unlock sophisticated techniques that were developed in regular entanglement detection and to use them for certifying steerability. As an application, we show that this allows us to go beyond even the canonical steering scenario; it enables a generalized dimension-bounded steering where one only assumes the Hilbert space dimension on the characterized side, with no description of the measurements. Surprisingly, this does not weaken the detection strength of very symmetric scenarios that have recently been carried out in experiments. PMID:26991159

  6. Droplet electrochemical study of the pH dependent redox behavior of novel ferrocenyl-carborane derivatives and its application in specific cancer cell recognition

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Changyu [State Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, Nanjing 210096 (China); Shah, Afzal [Department of Chemistry, Quaid-i-Azam University, Islamabad 45320 (Pakistan); Ye, Hongde [State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093 (China); Chen, Xiao; Ye, Jing; Jiang, Hui [State Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, Nanjing 210096 (China); Chen, Baoan [Department of Hematology, the Affiliated Zhongda Hospital, Clinical Medical School, Southeast University, Nanjing 210009 (China); Wang, Xuemei, E-mail: xuewang@seu.edu.cn [State Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, Nanjing 210096 (China); Yan, Hong, E-mail: hyan1965@nju.edu.cn [State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093 (China)

    2015-02-01

    Highlights: • Electrochemical behaviors of novel ferrocenyl based carboranes (FcCB) were explored with a droplet system. • The shifts of peak potentials with changes of pH values indicated the involvement of proton during electron transfer reaction. • Normal cells and cancer cells could be specifically recognized by using FcCB as probe. • This electrochemical method in a droplet shows great potential application for relevant diagnostics of clinical samples. - Abstract: Novel ferrocenyl based carboranes (FcCBs) and their distinguish behavior for cancer cell recognition have been explored in this contribution. The voltammetric study in a droplet of 10 μL placed on the surface of a glassy carbon electrode demonstrates the excellent electrochemical behavior of FcCBs, which could be further exploited for establishing the promising and sensitive biosensors. The FcCBs’ redox behavior is examined in a wide pH range, and square wave voltammetry revealed the reversible and irreversible nature of first and second anodic peaks. The obvious shifts in peak potentials corresponding with the change of pH values demonstrate the abstraction of electrons to be accompanied with the transfer of protons. By using the droplet electrochemical technique, FcCBs can be employed to distinguish normal and cancer cells with a linear range from 1.0 × 10{sup 3} to 3.0 × 10{sup 4} cells mL{sup −1} and the limit of detection at 800 cells mL{sup −1}. The novel carborane derivatives could be utilized as important potential molecular probes for specific recognition of cancer cells like leukemia cells from normal cells.

  7. Droplet electrochemical study of the pH dependent redox behavior of novel ferrocenyl-carborane derivatives and its application in specific cancer cell recognition

    International Nuclear Information System (INIS)

    Highlights: • Electrochemical behaviors of novel ferrocenyl based carboranes (FcCB) were explored with a droplet system. • The shifts of peak potentials with changes of pH values indicated the involvement of proton during electron transfer reaction. • Normal cells and cancer cells could be specifically recognized by using FcCB as probe. • This electrochemical method in a droplet shows great potential application for relevant diagnostics of clinical samples. - Abstract: Novel ferrocenyl based carboranes (FcCBs) and their distinguish behavior for cancer cell recognition have been explored in this contribution. The voltammetric study in a droplet of 10 μL placed on the surface of a glassy carbon electrode demonstrates the excellent electrochemical behavior of FcCBs, which could be further exploited for establishing the promising and sensitive biosensors. The FcCBs’ redox behavior is examined in a wide pH range, and square wave voltammetry revealed the reversible and irreversible nature of first and second anodic peaks. The obvious shifts in peak potentials corresponding with the change of pH values demonstrate the abstraction of electrons to be accompanied with the transfer of protons. By using the droplet electrochemical technique, FcCBs can be employed to distinguish normal and cancer cells with a linear range from 1.0 × 103 to 3.0 × 104 cells mL−1 and the limit of detection at 800 cells mL−1. The novel carborane derivatives could be utilized as important potential molecular probes for specific recognition of cancer cells like leukemia cells from normal cells

  8. Quantum coherence of steered states

    Science.gov (United States)

    Hu, Xueyuan; Milne, Antony; Zhang, Boyang; Fan, Heng

    2016-01-01

    Lying at the heart of quantum mechanics, coherence has recently been studied as a key resource in quantum information theory. Quantum steering, a fundamental notion originally considered by Schödinger, has also recently received much attention. When Alice and Bob share a correlated quantum system, Alice can perform a local measurement to ‘steer’ Bob’s reduced state. We introduce the maximal steered coherence as a measure describing the extent to which steering can remotely create coherence; more precisely, we find the maximal coherence of Bob’s steered state in the eigenbasis of his original reduced state, where maximization is performed over all positive-operator valued measurements for Alice. We prove that maximal steered coherence vanishes for quantum-classical states whilst reaching a maximum for pure entangled states with full Schmidt rank. Although invariant under local unitary operations, maximal steered coherence may be increased when Bob performs a channel. For a two-qubit state we find that Bob’s channel can increase maximal steered coherence if and only if it is neither unital nor semi-classical, which coincides with the condition for increasing discord. Our results show that the power of steering for coherence generation, though related to discord, is distinct from existing measures of quantum correlation.

  9. Holographic memory using beam steering

    Science.gov (United States)

    Chao, Tien-Hsin (Inventor); Hanan, Jay C. (Inventor); Reyes, George F. (Inventor); Zhou, Hanying (Inventor)

    2007-01-01

    A method, apparatus, and system provide the ability for storing holograms at high speed. A single laser diode emits a collimated laser beam to both write to and read from a photorefractice crystal. One or more liquid crystal beam steering spatial light modulators (BSSLMs) steer a reference beam, split from the collimated laser beam, at high speed to the photorefractive crystal.

  10. Steer assistance for teleoperation

    Science.gov (United States)

    Pape, Olivier; Houbloup, Philippe; Leveque, Stephane

    2005-05-01

    Giat Industries, expert in combat system, designs and integrates the technologies (electrical network, mechanical design, ergonomic and mobility command and control) for the French military and civil robotic. One of the main problems of current robotics is to treat the lack of operator's perception due to teleoperation. The article details the assistance for the steer control part of mobility command and control. The purpose of the assistance is to secure the vehicle, to insure the continuity of the command (in particular for tracked vehicle equipped of hydrostatic steering group), and to adapt the command (to use all the range of the command even at high speed and to adapt the speed to the desired curve). The advantage of the system presented in the article is to filter the order first and to transmit to the actuators only safe orders preserving the vehicle. This approach transforms the telepilot's order watching and correction problem, to a telepilot's order filtering problem. We pass here, from a logical "a posteriori" to a logical of "a priori" processing. The assistance includes: a model of the dynamic behavior of the vehicle and an open loop, some feed forward with appropriate filters and a closed loop. The article presents the result of the command studies from time simulation to "man on the loop" simulation. This system, at present time applied to the French Observation Robot demonstrator SYRANO (developped for the DGA-French Defence Procurement Agency), is the subject of a patent.

  11. Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition.

    Directory of Open Access Journals (Sweden)

    Danielle B Ulanet

    Full Text Available Recent work has highlighted glutaminase (GLS as a key player in cancer cell metabolism, providing glutamine-derived carbon and nitrogen to pathways that support proliferation. There is significant interest in targeting GLS for cancer therapy, although the gene is not known to be mutated or amplified in tumors. As a result, identification of tractable markers that predict GLS dependence is needed for translation of GLS inhibitors to the clinic. Herein we validate a small molecule inhibitor of GLS and show that non-small cell lung cancer cells marked by low E-cadherin and high vimentin expression, hallmarks of a mesenchymal phenotype, are particularly sensitive to inhibition of the enzyme. Furthermore, lung cancer cells induced to undergo epithelial to mesenchymal transition (EMT acquire sensitivity to the GLS inhibitor. Metabolic studies suggest that the mesenchymal cells have a reduced capacity for oxidative phosphorylation and increased susceptibility to oxidative stress, rendering them unable to cope with the perturbations induced by GLS inhibition. These findings elucidate selective metabolic dependencies of mesenchymal lung cancer cells and suggest novel pathways as potential targets in this aggressive cancer type.

  12. Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy.

    Science.gov (United States)

    Wu, Meiying; Meng, Qingshuo; Chen, Yu; Zhang, Lingxia; Li, Mengli; Cai, Xiaojun; Li, Yaping; Yu, Pengcheng; Zhang, Linlin; Shi, Jianlin

    2016-03-01

    A stability-difference-selective bond-breakage strategy for the fabrication of largepore-sized hollow mesoporous organosilica nanoparticles (HMONs) is successfully developed. Moreover, surfacefunctionalized HMONs are successfully constructed to simultaneously deliver P-gp modulator siRNA and anticancer drug doxorubicin to reverse the multidrug resistance of cancer cells. PMID:26743228

  13. STEER Coastal Use Mapping Project

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Coastal Use Mapping Project is designed to collect critical information on human activities in and near the St. Thomas East End Reserves (STEER). The project...

  14. Quantification of Gaussian quantum steering

    CERN Document Server

    Kogias, Ioannis; Ragy, Sammy; Adesso, Gerardo

    2014-01-01

    Einstein-Podolsky-Rosen steering incarnates a useful nonclassical correlation which sits in-between entanglement and Bell nonlocality. While a number of qualitative steering criteria exist, very little has been achieved for what concerns quantifying steerability. We introduce a computable measure of steering for arbitrary bipartite Gaussian states of continuous variable systems. For two-mode Gaussian states, the measure reduces to a form of coherent information, which is proven never to exceed entanglement, and to reduce to it on pure states. We provide an operational connection between our measure and the key rate in one-sided device-independent quantum key distribution. We further prove that steering bound entangled Gaussian states by Gaussian measurements is impossible.

  15. Frequency Steered Acoustic Transducer Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Small Business Innovation Research Phase I project is to develop, fabricate, and characterize a novel frequency steered acoustic transducer (FSAT) for the...

  16. Frequency Steered Acoustic Transducer Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Small Business Innovation Research Phase II project is to fabricate, characterize, and verify performance of a new type of frequency steered acoustic...

  17. Simultaneous electrochemical detection of cervical cancer markers using reduced graphene oxide-tetraethylene pentamine as electrode materials and distinguishable redox probes as labels.

    Science.gov (United States)

    Wu, Dan; Guo, Aiping; Guo, Zhankui; Xie, Lili; Wei, Qin; Du, Bin

    2014-04-15

    A novel, highly sensitive electrochemical immunoassay was proposed for the simultaneous determination of carcinoembryonic antigen (CEA) and squamous cell carcinoma antigen (SCCA) for the diagnosis of cervical cancer. Using an electrochemical analysis technique, two well-separated peaks were generated by neutral red and thionine, making the simultaneous detection of the two analytes on the electrode possible. Reduced graphene oxide-tetraethylene pentamine (rGO-TEPA), containing more amino groups, was of benefit to immobilize the primary antibody (Ab1) through an amidation reaction. Au@mesoporous carbon CMK-3 was synthesized and incubated with two secondary antibodies (Ab2) and different redox probes (neutral red and thionine) to fabricate the electrochemical immunosensor label intending to improve the analytical performance of the immunosensor. The immunosensor was prepared with a sandwich structure based on the peak current change of neutral red and thionine before and after the antigen-antibody reaction. The results showed that the immunosensor had a wide linear range, low detection limit, good reproducibility and stability. The method has been applied to the analysis of serum samples with satisfactory results. PMID:24333936

  18. Mitochondria: Redox Metabolism and Dysfunction

    OpenAIRE

    Jia Kang; Shazib Pervaiz

    2012-01-01

    Mitochondria are the main intracellular location for fuel generation; however, they are not just power plants but involved in a range of other intracellular functions including regulation of redox homeostasis and cell fate. Dysfunction of mitochondria will result in oxidative stress which is one of the underlying causal factors for a variety of diseases including neurodegenerative diseases, diabetes, cardiovascular diseases, and cancer. In this paper, generation of reactive oxygen/nitrogen sp...

  19. Responder fast steering mirror

    Science.gov (United States)

    Bullard, Andrew; Shawki, Islam

    2013-10-01

    Raytheon Space and Airborne Systems (SAS) has designed, built and tested a 3.3-inch diameter fast steering mirror (FSM) for space application. This 2-axis FSM operates over a large angle (over 10 degree range), has a very high servo bandwidth (over 3.3 Khz closed loop bandwidth), has nanoradian-class noise, and is designed to support microradian class line of sight accuracy. The FSM maintains excellent performance over large temperature ranges (which includes wave front error) and has very high reliability with the help of fully redundant angle sensors and actuator circuits. The FSM is capable of achieving all its design requirements while also being reaction-compensated. The reaction compensation is achieved passively and does not need a separate control loop. The FSM has undergone various environmental testing which include exported forces and torques and thermal vacuum testing that support the FSM design claims. This paper presents the mechanical design and test results of the mechanism which satisfies the rigorous vacuum and space application requirements.

  20. The Redox Proteome*

    OpenAIRE

    Go, Young-Mi; Jones, Dean P.

    2013-01-01

    The redox proteome consists of reversible and irreversible covalent modifications that link redox metabolism to biologic structure and function. These modifications, especially of Cys, function at the molecular level in protein folding and maturation, catalytic activity, signaling, and macromolecular interactions and at the macroscopic level in control of secretion and cell shape. Interaction of the redox proteome with redox-active chemicals is central to macromolecular structure, regulation,...

  1. Fermilab Steering Group Report

    Energy Technology Data Exchange (ETDEWEB)

    Beier, Eugene; /Pennsylvania U.; Butler, Joel; /Fermilab; Dawson, Sally; /Brookhaven; Edwards, Helen; /Fermilab; Himel, Thomas; /SLAC; Holmes, Stephen; /Fermilab; Kim, Young-Kee; /Fermilab /Chicago U.; Lankford, Andrew; /UC, Irvine; McGinnis, David; /Fermilab; Nagaitsev, Sergei; /Fermilab; Raubenheimer, Tor; /SLAC /Fermilab

    2007-01-01

    The Fermilab Steering Group has developed a plan to keep U.S. accelerator-based particle physics on the pathway to discovery, both at the Terascale with the LHC and the ILC and in the domain of neutrinos and precision physics with a high-intensity accelerator. The plan puts discovering Terascale physics with the LHC and the ILC as Fermilab's highest priority. While supporting ILC development, the plan creates opportunities for exciting science at the intensity frontier. If the ILC remains near the Global Design Effort's technically driven timeline, Fermilab would continue neutrino science with the NOVA experiment, using the NuMI (Neutrinos at the Main Injector) proton plan, scheduled to begin operating in 2011. If ILC construction must wait somewhat longer, Fermilab's plan proposes SNuMI, an upgrade of NuMI to create a more powerful neutrino beam. If the ILC start is postponed significantly, a central feature of the proposed Fermilab plan calls for building an intense proton facility, Project X, consisting of a linear accelerator with the currently planned characteristics of the ILC combined with Fermilab's existing Recycler Ring and the Main Injector accelerator. The major component of Project X is the linac. Cryomodules, radio-frequency distribution, cryogenics and instrumentation for the linac are the same as or similar to those used in the ILC at a scale of about one percent of a full ILC linac. Project X's intense proton beams would open a path to discovery in neutrino science and in precision physics with charged leptons and quarks. World-leading experiments would allow physicists to address key questions of the Quantum Universe: How did the universe come to be? Are there undiscovered principles of nature: new symmetries, new physical laws? Do all the particles and forces become one? What happened to the antimatter? Building Project X's ILC-like linac would offer substantial support for ILC development by accelerating the

  2. Fermilab Steering Group Report

    Energy Technology Data Exchange (ETDEWEB)

    Steering Group, Fermilab; /Fermilab

    2007-12-01

    The Fermilab Steering Group has developed a plan to keep U.S. accelerator-based particle physics on the pathway to discovery, both at the Terascale with the LHC and the ILC and in the domain of neutrinos and precision physics with a high-intensity accelerator. The plan puts discovering Terascale physics with the LHC and the ILC as Fermilab's highest priority. While supporting ILC development, the plan creates opportunities for exciting science at the intensity frontier. If the ILC remains near the Global Design Effort's technically driven timeline, Fermilab would continue neutrino science with the NOvA experiment, using the NuMI (Neutrinos at the Main Injector) proton plan, scheduled to begin operating in 2011. If ILC construction must wait somewhat longer, Fermilab's plan proposes SNuMI, an upgrade of NuMI to create a more powerful neutrino beam. If the ILC start is postponed significantly, a central feature of the proposed Fermilab plan calls for building an intense proton facility, Project X, consisting of a linear accelerator with the currently planned characteristics of the ILC combined with Fermilab's existing Recycler Ring and the Main Injector accelerator. The major component of Project X is the linac. Cryomodules, radio-frequency distribution, cryogenics and instrumentation for the linac are the same as or similar to those used in the ILC at a scale of about one percent of a full ILC linac. Project X's intense proton beams would open a path to discovery in neutrino science and in precision physics with charged leptons and quarks. World-leading experiments would allow physicists to address key questions of the Quantum Universe: How did the universe come to be? Are there undiscovered principles of nature: new symmetries, new physical laws? Do all the particles and forces become one? What happened to the antimatter? Building Project X's ILC-like linac would offer substantial support for ILC development by accelerating the

  3. Redox-responsive targeted gelatin nanoparticles for delivery of combination wt-p53 expressing plasmid DNA and gemcitabine in the treatment of pancreatic cancer

    International Nuclear Information System (INIS)

    Pancreatic adenocarcinoma is one of the most dreaded cancers with very low survival rate and poor prognosis to the existing frontline chemotherapeutic drugs. Gene therapy in combination with a cytotoxic agent could be a promising approach to circumvent the limitations of previously attempted therapeutic interventions. We have developed a redox-responsive thiolated gelatin based nanoparticle system that efficiently delivers its payload in the presence of glutathione-mediated reducing intra-cellular environment and could be successfully used for site-specific wt-p53 expressing plasmid DNA as well as gemcitabine delivery by targeting epidermal growth factor receptor (EGFR). Efficacy studies were performed in subcutaneous human adenocarcinoma bearing SCID beige mice along with molecular level p53 plasmid and apoptotic marker expression by PCR and western blot for all study groups. Efficacy studies demonstrate an improved in vivo targeting efficiency resulting in increased transfection efficiency and tumor growth suppression. In all the treatment groups, the targeted nanoparticles showed better anti-tumor activity than their non-targeted as well as non-encapsulated, naked therapeutic agent counterparts (50.1, 61.7 and 77.3% tumor regression by p53 plasmid alone, gemcitabine alone and in combination respectively). Molecular analysis revealed a higher mRNA expression of transfected p53 gene, its corresponding protein and that the tumor cell death in all treatment groups was due to the induction of apoptotic pathways. Gene/drug combination treatment significantly improves the therapeutic performance of the delivery system compared to the gene or drug alone treated groups. Anti-tumor activity of the thiolated gelatin loaded wt-p53 plasmid or gemcitabine-based therapy was attributed to their ability to induce cell apoptosis, which was confirmed by a marked increase in mRNA level of proapoptotic transcription factors, as well as, protein apoptotic biomarker expression and

  4. Neurobehavioral radiation mitigation to standard brain cancer therapy regimens by Mn(III) n-butoxyethylpyridylporphyrin-based redox modifier.

    Science.gov (United States)

    Weitzel, Douglas H; Tovmasyan, Artak; Ashcraft, Kathleen A; Boico, Alina; Birer, Samuel R; Roy Choudhury, Kingshuk; Herndon, James; Rodriguiz, Ramona M; Wetsel, William C; Peters, Katherine B; Spasojevic, Ivan; Batinic-Haberle, Ines; Dewhirst, Mark W

    2016-06-01

    Combinations of radiotherapy (RT) and chemotherapy have shown efficacy toward brain tumors. However, therapy-induced oxidative stress can damage normal brain tissue, resulting in both progressive neurocognitive loss and diminished quality of life. We have recently shown that MnTnBuOE-2-PyP(5+) (Mn(III)meso-tetrakis(N-n-butoxyethylpyridinium -2-yl)porphyrin) rescued RT-induced white matter damage in cranially-irradiated mice. Radiotherapy is not used in isolation for treatment of brain tumors; temozolomide is the standard-of-care for adult glioblastoma, whereas cisplatin is often used for treatment of pediatric brain tumors. Therefore, we evaluated the brain radiation mitigation ability of MnTnBuOE-2-PyP(5+) after either temozolomide or cisplatin was used singly or in combination with 10 Gy RT. MnTnBuOE-2-PyP(5+) accumulated in brains at low nanomolar levels. Histological and neurobehavioral testing showed a drastic decrease (1) of axon density in the corpus callosum and (2) rotorod and running wheel performance in the RT only treatment group, respectively. MnTnBuOE-2-PyP(5+) completely rescued this phenotype in irradiated animals. In the temozolomide groups, temozolomide/ RT treatment resulted in further decreased rotorod responses over RT alone. Again, MnTnBuOE-2-PyP(5+) treatment rescued the negative effects of both temozolomide ± RT on rotorod performance. While the cisplatin-treated groups did not give similar results as the temozolomide groups, inclusion of MnTnBuOE-2-PyP(5+) did not negatively affect rotorod performance. Additionally, MnTnBuOE-2-PyP(5+) sensitized glioblastomas to either RT ± temozolomide in flank tumor models. Mice treated with both MnTnBuOE-2-PyP(5+) and radio-/chemo-therapy herein demonstrated brain radiation mitigation. MnTnBuOE-2-PyP(5+) may well serve as a normal tissue radio-/chemo-mitigator adjuvant therapy to standard brain cancer treatment regimens. Environ. Mol. Mutagen. 57:372-381, 2016. © 2016 Wiley Periodicals, Inc

  5. Anticancer Activity of Metal Complexes: Involvement of Redox Processes

    OpenAIRE

    Jungwirth, Ute; Kowol, Christian R.; Keppler, Bernhard K; Hartinger, Christian G.; Berger, Walter; Heffeter, Petra

    2011-01-01

    Cells require tight regulation of the intracellular redox balance and consequently of reactive oxygen species for proper redox signaling and maintenance of metal (e.g., of iron and copper) homeostasis. In several diseases, including cancer, this balance is disturbed. Therefore, anticancer drugs targeting the redox systems, for example, glutathione and thioredoxin, have entered focus of interest. Anticancer metal complexes (platinum, gold, arsenic, ruthenium, rhodium, copper, vanadium, cobalt,...

  6. Steering projections in von Neumann algebras

    OpenAIRE

    Adam Wegert

    2015-01-01

    A steering projection of an arbitrary von Neumann algebra is introduced. It is shown that a steering projection always exists and is unique (up to Murray-von Neumann equivalence). A general decomposition of arbitrary projections with respect to a steering projection is established.

  7. 46 CFR 176.814 - Steering systems.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Steering systems. 176.814 Section 176.814 Shipping COAST...) INSPECTION AND CERTIFICATION Material Inspections § 176.814 Steering systems. At each initial and subsequent inspection for certification the owner or managing operator shall be prepared to test the steering systems...

  8. Necrobacillary bronchopneumonia in a steer.

    OpenAIRE

    Bundza, A; Garcia, M. M.; Kokoskin-Nelson, E

    1987-01-01

    A one and one-half year old steer killed in a slaughterhouse had necrobacillary fibrinous bronchopneumonia with abscessation. Histologically, there were variably sized areas of coagulation necrosis in the lungs, thrombosis of pulmonary lymphatics, and fibrin deposits in the bronchioli and adjacent alveoli. Fusobacterium necrophorum in pure culture was isolated from the lung.

  9. Objective Evaluation Method of Steering Comfort Based on Movement Quality Evaluation of Driver Steering Maneuver

    Institute of Scientific and Technical Information of China (English)

    YANG Yiyong; LIU Yahui; WANG Man; JI Run; JI Xuewu

    2014-01-01

    The existing research of steering comfort mainly focuses on the subjective evaluation, aiming at designing and optimizing the steering system. In the development of steering system, especially the evaluation of steering comfort, the objective evaluation methods considered the kinematic characteristics of driver steering maneuver are not proposed, which means that the objective evaluation of steering cannot be conducted with the evaluation of kinematic characteristics of driver in steering maneuver. In order to propose the objective evaluation methods of steering comfort, the evaluation of steering movement quality of driver is developed on the basis of the study of the kinematic characteristics of steering maneuver. First, the steering motion trajectories of the driver in both comfortable and certain extreme uncomfortable operation conditions are detected using the Vicon motion capture system. The operation conditions are under the restrictions of the vertical height and horizontal distance between steering wheel center and the H-point of driver, and the steering resisting torque else. Next, the movement quality evaluation of driver steering maneuver is assessed using twelve kinds of evaluation indices based on the kinematic analyses of the steering motion trajectories to propose an objective evaluation method. Finally, an integrated discomfort index of steering maneuver is proposed on the basis of the regression analysis of subjective evaluation rating and the movement quality evaluation indices, including the Jerk, Discomfort and Joint Torque indices. The test results show that the proposed integrated discomfort index gives a good fitting with the subjective evaluation of discomfort, which means it can be used to evaluate or predict the discomfort level of steering maneuver. This paper proposes an objective evaluation method of steering comfort based on the movement quality evaluation of driver steering maneuver.

  10. Plant redox proteomics

    DEFF Research Database (Denmark)

    Navrot, Nicolas; Finnie, Christine; Svensson, Birte;

    2011-01-01

    PTMs in regulating enzymatic activities and controlling biological processes in plants. Notably, proteins controlling the cellular redox state, e.g. thioredoxin and glutaredoxin, appear to play dual roles to maintain oxidative stress resistance and regulate signal transduction pathways via redox PTMs...

  11. Proactive Steering Toward Oriented Targets

    OpenAIRE

    Boulic, R

    2005-01-01

    In this paper we introduce a real-time steering controller ensuring the reach of a (possible mobile) target position and orientation, without requiring to build/update the full trajectory to that target. We name it the funnelling control. The final orientation is achieved through the continuous adjustment of the heading direction. This control mode is proactive in the sense that it anticipates the success/failure of the reach and adjusts the desired speed accordingly. Both features rely on an...

  12. 46 CFR 182.610 - Main steering gear.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Main steering gear. 182.610 Section 182.610 Shipping...) MACHINERY INSTALLATION Steering Systems § 182.610 Main steering gear. (a) A vessel must be provided with a main steering gear that is: (1) Of adequate strength and capable of steering the vessel at all...

  13. Detecting genuine multipartite entanglement in steering scenarios

    Science.gov (United States)

    Jebaratnam, C.

    2016-05-01

    Einstein-Podolsky-Rosen (EPR) steering is a form of quantum nonlocality which is intermediate between entanglement and Bell nonlocality. EPR steering is a resource for quantum key distribution that is device independent on only one side in that it certifies bipartite entanglement when one party's device is not characterized while the other party's device is fully characterized. In this work, we introduce two types of genuine tripartite EPR steering, and derive two steering inequalities to detect them. In a semi-device-independent scenario where only the dimensions of two parties are assumed, the correlations which violate one of these inequalities also certify genuine tripartite entanglement. It is known that Alice can demonstrate bipartite EPR steering to Bob if and only if her measurement settings are incompatible. We demonstrate that quantum correlations can also detect tripartite EPR steering from Alice to Bob and Charlie, even if Charlie's measurement settings are compatible.

  14. HUMAN-SIMULATING VEHICLE STEERING CONTROL ALGORITHM

    Institute of Scientific and Technical Information of China (English)

    XU Youchun; LI Keqiang; CHANG Ming; CHEN Jun

    2006-01-01

    A new vehicle steering control algorithm is presented. Unlike the traditional methods do,the algorithm uses a sigmoid function to describe the principle of the human driver's steering strategy.Based on this function, a human simulating vehicle steering model, human-simulating steering control(HS) algorithm is designed. In order to improve the adaptability to different environments, a parameter adaptive adjustment algorithm is presented. This algorithm can online modify the value of the key parameters of the HS real time. HS controller is used on a vehicle equipped with computer vision system and computer controlled steering actuator system, the result from the automatic vehicle steering experiment shows that the HS algorithm gives good performance at different speed, even at the maximum speed of 172 km/h.

  15. Vehicle Steering control: A model of learning

    Science.gov (United States)

    Smiley, A.; Reid, L.; Fraser, M.

    1978-01-01

    A hierarchy of strategies were postulated to describe the process of learning steering control. Vehicle motion and steering control data were recorded for twelve novices who drove an instrumented car twice a week during and after a driver training course. Car-driver describing functions were calculated, the probable control structure determined, and the driver-alone transfer function modelled. The data suggested that the largest changes in steering control with learning were in the way the driver used the lateral position cue.

  16. A beam steering technique using dielectric wedges.

    OpenAIRE

    Khan, M. R.

    1995-01-01

    The thesis describes a method of' beam steering aimed at producing a useful amount of deflection of an antenna beam from boresight, by a simple and Inexpensive method. For large antennas, It is difficult, as well as expensive, to steer the beam by more than a few beamwidths. The method studied was developed with particular reference to the beam steering requirements of Direct Broadcast Satellite flat plate antennas. The method involves two dielectric wedges, having cir...

  17. Classical communication cost of quantum steering

    Science.gov (United States)

    Sainz, Ana Belén; Aolita, Leandro; Brunner, Nicolas; Gallego, Rodrigo; Skrzypczyk, Paul

    2016-07-01

    Quantum steering is observed when performing appropriate local measurements on an entangled state. Here we discuss the possibility of simulating classically this effect, using classical communication instead of entanglement. We show that infinite communication is necessary for exactly simulating steering for any pure entangled state, as well as for a class of mixed entangled states. Moreover, we discuss the communication cost of steering for general entangled states, as well as approximate simulation. Our findings reveal striking differences between Bell nonlocality and steering and provide a natural way of measuring the strength of the latter.

  18. Driver behavior following an automatic steering intervention.

    Science.gov (United States)

    Fricke, Nicola; Griesche, Stefan; Schieben, Anna; Hesse, Tobias; Baumann, Martin

    2015-10-01

    The study investigated driver behavior toward an automatic steering intervention of a collision mitigation system. Forty participants were tested in a driving simulator and confronted with an inevitable collision. They performed a naïve drive and afterwards a repeated exposure in which they were told to hold the steering wheel loosely. In a third drive they experienced a false alarm situation. Data on driving behavior, i.e. steering and braking behavior as well as subjective data was assessed in the scenarios. Results showed that most participants held on to the steering wheel strongly or counter-steered during the system intervention during the first encounter. Moreover, subjective data collected after the first drive showed that the majority of drivers was not aware of the system intervention. Data from the repeated drive in which participants were instructed to hold the steering wheel loosely, led to significantly more participants holding the steering wheel loosely and thus complying with the instruction. This study seems to imply that without knowledge and information of the system about an upcoming intervention, the most prevalent driving behavior is a strong reaction with the steering wheel similar to an automatic steering reflex which decreases the system's effectiveness. Results of the second drive show some potential for countermeasures, such as informing drivers shortly before a system intervention in order to prevent inhibiting reactions. PMID:26310799

  19. Steering in loco-regional deep hyperthermia: evaluation of common practice with 3D-planning

    International Nuclear Information System (INIS)

    Full text: Radiotherapy plus hyperthermia is standard treatment for locally advanced cervical cancer. In our unit the hyperthermia treatment of these patients is performed with a BSD 2000 3D deep hyperthermia system. In order to apply loco-regional deep hyperthermia at a maximum dose level, protocolized SAR steering is used to optimize tumor temperatures, avoid toxicity and minimize complaints due to local overheating. SAR steering is the term we use to address all changes in antenna settings that affect the distribution of dissipated power. The protocol used to guide SAR steering reflects an empirical strategy based on the experience gathered over the last decade. With the availability of sophisticated codes to predict patient specific EM fields, we are now able to prospectively evaluate the effectiveness of the applied amplitude and phase settings, and of the steering protocol. In this study, we evaluate the effect of prescribed steering actions in a patient model according to the treatment protocol. In particular, we assess the effectiveness of both phase and amplitude steering to control power dissipation at the tumor location and at the surface. From the simulations it is clear that the SAR focus within the pelvis falls apart in three different maxima. One located at the ventral side and associated with the os pubis, one located at the backside and associated with the lumbosacral vertebrae, and one in the middle associated with the tumor volume. Instead of continuously shifting the SAR focus, both phase- and amplitude steering in the AP direction merely changes the ratio of dissipated power in the three different areas. To elucidate the difference between phase and amplitude steering in the AP direction, we divide our patient model in three regions of interest. These regions are indicated as front (f), middle (m) and back (b). For these regions total integrated power absorption was calculated at a range of phase and amplitude settings. In figure 1a the ratio

  20. 78 FR 23961 - Request for Steering Committee Nominations

    Science.gov (United States)

    2013-04-23

    ... THE FOOD AND DRUG ADMINISTRATION Request for Steering Committee Nominations ACTION: Request for nominations to the Steering Committee for the Foundation's Innovation in Medical Evidence Development and... Innovation in Medical Evidence Development and Surveillance (IMEDS) Steering Committee. The IMEDS...

  1. Multi-Layer Traffic Steering

    DEFF Research Database (Denmark)

    Fotiadis, Panagiotis; Polignano, Michele; Gimenez, Lucas Chavarria; Viering, Ingo; Sartori, Cinzia; Lobinger, Andreas; Pedersen, Klaus I.

    2013-01-01

    This paper investigates the potentials of traffic steering in the Radio Resource Control (RRC) Idle state by evaluating the Absolute Priorities (AP) framework in a multilayer Long Term Evolution (LTE) macrocell scenario. Frequency priorities are broadcast on the system information and RRC Idle...... signaling. The priority adjustment is based on both the Composite Available Capacity (CAC) and the radio conditions of the candidate layers. Compared to broadcast AP, the proposed scheme achieves better load balancing performance and improves network capacity, given that the User Equipment (UE) inactivity...

  2. A new model to compute the desired steering torque for steer-by-wire vehicles and driving simulators

    Science.gov (United States)

    Fankem, Steve; Müller, Steffen

    2014-05-01

    This paper deals with the control of the hand wheel actuator in steer-by-wire (SbW) vehicles and driving simulators (DSs). A novel model for the computation of the desired steering torque is presented. The introduced steering torque computation does not only aim to generate a realistic steering feel, which means that the driver should not miss the basic steering functionality of a modern conventional steering system such as an electric power steering (EPS) or hydraulic power steering (HPS), and this in every driving situation. In addition, the modular structure of the steering torque computation combined with suitably selected tuning parameters has the objective to offer a high degree of customisability of the steering feel and thus to provide each driver with his preferred steering feel in a very intuitive manner. The task and the tuning of each module are firstly described. Then, the steering torque computation is parameterised such that the steering feel of a series EPS system is reproduced. For this purpose, experiments are conducted in a hardware-in-the-loop environment where a test EPS is mounted on a steering test bench coupled with a vehicle simulator and parameter identification techniques are applied. Subsequently, how appropriate the steering torque computation mimics the test EPS system is objectively evaluated with respect to criteria concerning the steering torque level and gradient, the feedback behaviour and the steering return ability. Finally, the intuitive tuning of the modular steering torque computation is demonstrated for deriving a sportier steering feel configuration.

  3. 49 CFR 570.7 - Steering systems.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Steering systems. 570.7 Section 570.7 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY... a front wheel. If a point on the steering wheel rim moves more than the value shown in Table...

  4. Redox Species of Redox Flow Batteries: A Review.

    Science.gov (United States)

    Pan, Feng; Wang, Qing

    2015-01-01

    Due to the capricious nature of renewable energy resources, such as wind and solar, large-scale energy storage devices are increasingly required to make the best use of the renewable power. The redox flow battery is considered suitable for large-scale applications due to its modular design, good scalability and flexible operation. The biggest challenge of the redox flow battery is the low energy density. The redox active species is the most important component in redox flow batteries, and the redox potential and solubility of redox species dictate the system energy density. This review is focused on the recent development of redox species. Different categories of redox species, including simple inorganic ions, metal complexes, metal-free organic compounds, polysulfide/sulfur and lithium storage active materials, are reviewed. The future development of redox species towards higher energy density is also suggested. PMID:26593894

  5. Redox Species of Redox Flow Batteries: A Review

    Directory of Open Access Journals (Sweden)

    Feng Pan

    2015-11-01

    Full Text Available Due to the capricious nature of renewable energy resources, such as wind and solar, large-scale energy storage devices are increasingly required to make the best use of the renewable power. The redox flow battery is considered suitable for large-scale applications due to its modular design, good scalability and flexible operation. The biggest challenge of the redox flow battery is the low energy density. The redox active species is the most important component in redox flow batteries, and the redox potential and solubility of redox species dictate the system energy density. This review is focused on the recent development of redox species. Different categories of redox species, including simple inorganic ions, metal complexes, metal-free organic compounds, polysulfide/sulfur and lithium storage active materials, are reviewed. The future development of redox species towards higher energy density is also suggested.

  6. Operator space approach to steering inequality

    International Nuclear Information System (INIS)

    In Junge and Palazuelos (2011 Commun. Math. Phys. 306 695–746) and Junge et al (2010 Commun. Math. Phys. 300 715–39) the operator space theory was applied to study bipartite Bell inequalities. The aim of the paper is to follow this line of research and use the operator space technique to analyze the steering scenario. We obtain a bipartite steering functional with unbounded largest violation of steering inequality, as well as constructing all ingredients explicitly. It turns out that the unbounded largest violation is obtained by a non maximally entangled state. Moreover, we focus on the bipartite dichotomic case where we construct a steering functional with unbounded largest violation of steering inequality. This phenomenon is different to the Bell scenario where only the bounded largest violation can be obtained by any bipartite dichotomic Bell functional. (paper)

  7. Wireless traffic steering for green cellular networks

    CERN Document Server

    Zhang, Shan; Zhou, Sheng; Niu, Zhisheng; Shen, Xuemin (Sherman)

    2016-01-01

    This book introduces wireless traffic steering as a paradigm to realize green communication in multi-tier heterogeneous cellular networks. By matching network resources and dynamic mobile traffic demand, traffic steering helps to reduce on-grid power consumption with on-demand services provided. This book reviews existing solutions from the perspectives of energy consumption reduction and renewable energy harvesting. Specifically, it explains how traffic steering can improve energy efficiency through intelligent traffic-resource matching. Several promising traffic steering approaches for dynamic network planning and renewable energy demand-supply balancing are discussed. This book presents an energy-aware traffic steering method for networks with energy harvesting, which optimizes the traffic allocated to each cell based on the renewable energy status. Renewable energy demand-supply balancing is a key factor in energy dynamics, aimed at enhancing renewable energy sustainability to reduce on-grid energy consum...

  8. Investigation of Motorcycle Steering Torque Components

    Science.gov (United States)

    Cossalter, V.; Lot, R.; Massaro, M.; Peretto, M.

    2011-10-01

    When driving along a circular path, the rider controls a motorcycle mainly by the steering torque. This work addresses an in-depth analysis of the steady state cornering and in particular the decomposition of the motorcycle steering torque in its main components, such as road-tyre forces, gyroscopic torques, centrifugal and gravity effects. A detailed and experimentally validated multibody model of the motorcycle is used herein to analyze the steering torque components at different speeds and lateral accelerations. First the road tests are compared with the numerical results for three different vehicles and then a numerical investigation is carried out to decompose the steering torque. Finally, the effect of longitudinal acceleration and deceleration on steering torque components is presented.

  9. The Tumorigenic Roles of the Cellular REDOX Regulatory Systems

    OpenAIRE

    Stéphanie Anaís Castaldo; Joana Raquel Freitas; Nadine Vasconcelos Conchinha; Patrícia Alexandra Madureira

    2016-01-01

    The cellular REDOX regulatory systems play a central role in maintaining REDOX homeostasis that is crucial for cell integrity, survival, and proliferation. To date, a substantial amount of data has demonstrated that cancer cells typically undergo increasing oxidative stress as the tumor develops, upregulating these important antioxidant systems in order to survive, proliferate, and metastasize under these extreme oxidative stress conditions. Since a large number of chemotherapeutic agents cur...

  10. Beam Steering Devices Reduce Payload Weight

    Science.gov (United States)

    2012-01-01

    Scientists have long been able to shift the direction of a laser beam, steering it toward a target, but often the strength and focus of the light is altered. For precision applications, where the quality of the beam cannot be compromised, scientists have typically turned to mechanical steering methods, redirecting the source of the beam by swinging the entire laser apparatus toward the target. Just as the mechanical methods used for turning cars has evolved into simpler, lighter, power steering methods, so has the means by which researchers can direct lasers. Some of the typical contraptions used to redirect lasers are large and bulky, relying on steering gimbals pivoted, rotating supports to shift the device toward its intended target. These devices, some as large and awkward as a piece of heavy luggage, are subject to the same issues confronted by mechanical parts: Components rub, wear out, and get stuck. The poor reliability and bulk not to mention the power requirements to run one of the machines have made mechanical beam steering components less than ideal for use in applications where weight, bulk, and maneuverability are prime concerns, such as on an unmanned aerial vehicle (UAV) or a microscope. The solution to developing reliable, lighter weight, nonmechanical steering methods to replace the hefty steering boxes was to think outside the box, and a NASA research partner did just that by developing a new beam steering method that bends and redirects the beam, as opposed to shifting the entire apparatus. The benefits include lower power requirements, a smaller footprint, reduced weight, and better control and flexibility in steering capabilities. Such benefits are realized without sacrificing aperture size, efficiency, or scanning range, and can be applied to myriad uses: propulsion systems, structures, radiation protection systems, and landing systems.

  11. Redox Species of Redox Flow Batteries: A Review

    OpenAIRE

    Feng Pan; Qing Wang

    2015-01-01

    Due to the capricious nature of renewable energy resources, such as wind and solar, large-scale energy storage devices are increasingly required to make the best use of the renewable power. The redox flow battery is considered suitable for large-scale applications due to its modular design, good scalability and flexible operation. The biggest challenge of the redox flow battery is the low energy density. The redox active species is the most important component in redox flow batteries, and the...

  12. Automated beam steering using optimal control

    International Nuclear Information System (INIS)

    We present a steering algorithm which, with the aid of a model, allows the user to specify beam behavior throughout a beamline, rather than just at specified beam position monitor (BPM) locations. The model is used primarily to compute the values of the beam phase vectors from BPM measurements, and to define cost functions that describe the steering objectives. The steering problem is formulated as constrained optimization problem; however, by applying optimal control theory we can reduce it to an unconstrained optimization whose dimension is the number of control signals.

  13. 46 CFR 108.641 - Instructions for changing steering gear.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Instructions for changing steering gear. 108.641 Section... steering gear. Instructions stating, in order, the different steps to be taken for changing to emergency and secondary steering gear must be posted in the steering gear room and at each secondary...

  14. 46 CFR 58.25-20 - Piping for steering gear.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Piping for steering gear. 58.25-20 Section 58.25-20... MACHINERY AND RELATED SYSTEMS Steering Gear § 58.25-20 Piping for steering gear. (a) Pressure piping must... the hydraulic system can be readily recharged from within the steering-gear compartment and must...

  15. Digital Controller For Laser-Beam-Steering Subsystem: Part 2

    Science.gov (United States)

    Ansari, Homayoon; Voisinet, Leeann

    1995-01-01

    A report presents additional information about laser-beam-steering apparatus described in "Digital Controller for Laser-Beam-Steering Subsystem" (NPO-19193) and "More About Beam-Steering Subsystem for Laser Communication" (NPO-19381). Reiterates basic principles of operation of beam-steering subsystem, with emphasis on modes of operation, basic design concepts, and initial experiments on partial prototype of apparatus.

  16. Networks: structure and action : steering in and steering by policy networks

    OpenAIRE

    Dassen, Adrie

    2010-01-01

    This thesis explores the opportunities to build a structural policy network model that is rooted in social network theories. By making a distinction between a process of steering in networks, and a process of steering by networks, it addresses the effects of network structures on network dynamics as well as on the production of policy outputs. Steering in policy networks refers to the process of horizontal bargaining over policy positions in which resources are exchanged between individual ne...

  17. Electronic beam steering of semiconductor injection lasers

    Science.gov (United States)

    Katz, J.

    1982-01-01

    A theoretical analysis of the problem of beam steering is presented. The required modifications of the dielectric constant profile of the laser structure were derived. A practical method for implementing the needed modifications is outlined.

  18. Steering the ATLAS High Level Trigger

    CERN Document Server

    Comune, G; Morettini, P; Stamen, R; Tapprogge, S; George, S; Schiavi, C; Computing In High Energy and Nuclear Physics

    2006-01-01

    This paper describes the Steering mechanism of the ATLAS High Level Trigger (HLT). The Steering software is responsible for the implementation of the seeded and stepwise execution of algorithms in a portion of the full event called Region of Interest (RoI). The Steering is responsible for the global event accept/reject decision based on a static configuration matched against the dynamic event outcome in terms of Trigger Conditions validated by the Trigger algorithms. In the case of an event being accepted the Steering is in charge of the creation of the Detailed Event Result and in order to enable this it provides tools for reconstructed objects serialization and a fast data navigation mechanism that allows to organize the objects in memory with logical relations and all objects in an RoI back to the initial RoI seed.

  19. Redox Flow Batteries, a Review

    OpenAIRE

    Weber, Adam Z.

    2013-01-01

    Redox flow batteries are enjoying a renaissance due to their ability to store large amounts of electrical energy relatively cheaply and efficiently. In this review, we examine the components of redox flow batteries with a focus on understanding the underlying physical processes. The various transport and kinetic phenomena are discussed along with the most common redox couples.

  20. Redox Flow Batteries, a Review

    Energy Technology Data Exchange (ETDEWEB)

    Knoxville, U. Tennessee; U. Texas Austin; U, McGill; Weber, Adam Z.; Mench, Matthew M.; Meyers, Jeremy P.; Ross, Philip N.; Gostick, Jeffrey T.; Liu, Qinghua

    2011-07-15

    Redox flow batteries are enjoying a renaissance due to their ability to store large amounts of electrical energy relatively cheaply and efficiently. In this review, we examine the components of redox flow batteries with a focus on understanding the underlying physical processes. The various transport and kinetic phenomena are discussed along with the most common redox couples.

  1. New steering mechanism for wheeled mobile robots

    Institute of Scientific and Technical Information of China (English)

    Sidibe Marie Bernard; FU Yi-li; XU He; MA Yu-lin

    2007-01-01

    A new castor wheel mechanism for omni-directional mobile platform is presented. A motion of translation is transformed into a rotation to steer the wheel with the help of a helical path fits into a translation joint and three rollers whose axes are connected to the driving shaft of the wheel. When the path moves in translation it acts on the rollers for steering. The path-roller friction transmission, the wheel kinematics and the maneuverability have been analyzed.

  2. Highly sensitive beam steering with plasmonic antenna

    OpenAIRE

    Guanghao Rui; Qiwen Zhan

    2014-01-01

    In this work, we design and study a highly sensitive beam steering device that integrates a spiral plasmonic antenna with a subwavelength metallic waveguide. The short effective wavelength of the surface plasmon polaritons (SPPs) mode supported by the metallic waveguide is exploited to dramatically miniaturize the device and improve the sensitivity of the beam steering. Through introducing a tiny displacement of feed point with respect to the geometrical center of the spiral plasmonic antenna...

  3. Hybrid Beamforming and Steering With Reconfigurable Arrays

    OpenAIRE

    Hooi, Fong Ming; Thomenius, Kai E.; Fisher, Rayette; Carson, Paul L.

    2010-01-01

    Reconfigurable arrays offer an advantage over traditional ultrasound arrays because of their flexibility in channel selection. To improve ultrasound beamforming and coverage through beam steering, we propose a hybrid beamforming technique to elongate the depth of focus of transmit beams and a method of element selection that improves steering capabilities that take advantage of array reconfigurability using annular rings. A local minimization technique to optimize the hybrid aperture is discu...

  4. THz beam steering by optical coherent control

    OpenAIRE

    Füser, Heiko; Bieler, Mark

    2013-01-01

    We demonstrate optical coherent control of the emission direction of THz radiation. Femtosecond laser pulses are used to excite different types of ultrafast photocurrents along different directions in a bulk GaAs sample. The overall emission pattern can be modified by changing the phase of the optical excitation. With this method, THz beam steering of about 8 degrees is realized. A simple dipole-based model allows us to relate the size of the steering effect to the amplitude ratio between the...

  5. Improvement of motor inertia influence of electric power steering; Dendoshiki power steering no motor kansei no eikyo to hosho

    Energy Technology Data Exchange (ETDEWEB)

    Takehara, S.; Sakamoto, K.; Hanamoto, Y. [Mazda Motor Corp., Hiroshima (Japan); Noritsugu, T. [Okayama University, Okayama (Japan)

    1997-10-01

    Motor inertia of electric power steering affects not only steering characteristics but vehicle dynamics. We have investigated the influence of motor inertia and proposed a feedback strategy to compensate it. Weight of the test vehicle is 1100Kg and the steering system is pinion type electric power steering. By using simulation model and vehicle test, we have realized natural steering maneuvering and stable vehicle dynamics. 4 refs., 11 figs.

  6. Multipass Steering: A Reference Implementation

    Science.gov (United States)

    Hennessey, Michael; Tiefenback, Michael

    2015-10-01

    We introduce a reference implementation of a protocol to compute corrections that bring all beams in one of the CEBAF linear accelerators (linac) to axis, including, with a larger tolerance, the lowest energy pass using measured beam trajectory data. This method relies on linear optics as representation of the system; we treat beamline perturbations as magnetic field errors localized to regions between cryomodules, providing the same transverse momentum kick to each beam. We produce a vector of measured beam position data with which we left-multiply the pseudo-inverse of a coefficient array, A, that describes the transport of the beam through the linac using parameters that include the magnetic offsets of the quadrupole magnets, the instrumental offsets of the BPMs, and the beam initial conditions. This process is repeated using a reduced array to produce values that can be applied to the available correcting magnets and beam initial conditions. We show that this method is effective in steering the beam to a straight axis along the linac by using our values in elegant, the accelerator simulation program, on a model of the linac in question. The algorithms in this reference implementation provide a tool for systematic diagnosis and cataloging of perturbations in the beam line. Supported by Jefferson Lab, Old Dominion University, NSF, DOE.

  7. Distinct Redox Profiles of Selected Human Prostate Carcinoma Cell Lines: Implications for Rational Design of Redox Therapy

    International Nuclear Information System (INIS)

    The effects of several cancer chemotherapeutic drugs and radiation are mediated, at least in part, by oxidative stress. To better understand this process, we analyzed certain biochemical properties affecting reduction-oxidation (redox) balance in normal prostate epithelial cells and several prostate cancer cell lines. Highly aggressive androgen-independent prostate cancer PC3 cells demonstrated significantly higher levels of total antioxidant capacity (AC) and intra- and extracellular glutathione (GSH)/glutathione disulfide (GSSG) ratios when compared with normal prostate epithelial PrEC cells. WPE1-NB26 cells, a prostate cancer cell line derived from immortalized RWPE1 human prostate epithelial cells, demonstrated significantly higher levels of total AC and intra- and extracellular GSH/GSSG ratios, but lower levels of intracellular reactive oxygen/nitrogen species and lipid peroxidation compared with RWPE1 cells. LNCaP-C4-2 cells, a more aggressive prostate cancer derived from less aggressive androgen-responsive LNCaP cells, exhibited higher levels of AC and extracellular GSH/GSSG ratio when compared to LNCaP cells. Specific cell types showed distinct cytotoxic responses to redox-modulating compounds. WPE1-NB26 cells were more sensitive to phenethyl isothiocyanate and tumor necrosis factor (TNF) than RWPE1 cells, while PC3 cells were more sensitive to TNF than PrEC cells. These results are consistent with the hypothesis that cancer cell redox state may modulate responses to redox-modulating therapeutic regimens

  8. Distinct Redox Profiles of Selected Human Prostate Carcinoma Cell Lines: Implications for Rational Design of Redox Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Chaiswing, Luksana [Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, 1111 Highland Ave., WIMR 7168, Madison, WI 53705 (United States); Zhong, Weixiong; Oberley, Terry D., E-mail: toberley@wisc.edu [Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, 1111 Highland Ave., WIMR 7168, Madison, WI 53705 (United States); Pathology and Laboratory Medicine Service, William S. Middleton Memorial Veterans Hospital, Rm A-35, 2500 Overlook Terrace, Madison, WI 53705 (United States)

    2011-09-13

    The effects of several cancer chemotherapeutic drugs and radiation are mediated, at least in part, by oxidative stress. To better understand this process, we analyzed certain biochemical properties affecting reduction-oxidation (redox) balance in normal prostate epithelial cells and several prostate cancer cell lines. Highly aggressive androgen-independent prostate cancer PC3 cells demonstrated significantly higher levels of total antioxidant capacity (AC) and intra- and extracellular glutathione (GSH)/glutathione disulfide (GSSG) ratios when compared with normal prostate epithelial PrEC cells. WPE1-NB26 cells, a prostate cancer cell line derived from immortalized RWPE1 human prostate epithelial cells, demonstrated significantly higher levels of total AC and intra- and extracellular GSH/GSSG ratios, but lower levels of intracellular reactive oxygen/nitrogen species and lipid peroxidation compared with RWPE1 cells. LNCaP-C4-2 cells, a more aggressive prostate cancer derived from less aggressive androgen-responsive LNCaP cells, exhibited higher levels of AC and extracellular GSH/GSSG ratio when compared to LNCaP cells. Specific cell types showed distinct cytotoxic responses to redox-modulating compounds. WPE1-NB26 cells were more sensitive to phenethyl isothiocyanate and tumor necrosis factor (TNF) than RWPE1 cells, while PC3 cells were more sensitive to TNF than PrEC cells. These results are consistent with the hypothesis that cancer cell redox state may modulate responses to redox-modulating therapeutic regimens.

  9. Distinct Redox Profiles of Selected Human Prostate Carcinoma Cell Lines: Implications for Rational Design of Redox Therapy

    Directory of Open Access Journals (Sweden)

    Luksana Chaiswing

    2011-09-01

    Full Text Available The effects of several cancer chemotherapeutic drugs and radiation are mediated, at least in part, by oxidative stress. To better understand this process, we analyzed certain biochemical properties affecting reduction-oxidation (redox balance in normal prostate epithelial cells and several prostate cancer cell lines. Highly aggressive androgen-independent prostate cancer PC3 cells demonstrated significantly higher levels of total antioxidant capacity (AC and intra- and extracellular glutathione (GSH/glutathione disulfide (GSSG ratios when compared with normal prostate epithelial PrEC cells. WPE1-NB26 cells, a prostate cancer cell line derived from immortalized RWPE1 human prostate epithelial cells, demonstrated significantly higher levels of total AC and intra- and extracellular GSH/GSSG ratios, but lower levels of intracellular reactive oxygen/nitrogen species and lipid peroxidation compared with RWPE1 cells. LNCaP-C4-2 cells, a more aggressive prostate cancer derived from less aggressive androgen-responsive LNCaP cells, exhibited higher levels of AC and extracellular GSH/GSSG ratio when compared to LNCaP cells. Specific cell types showed distinct cytotoxic responses to redox-modulating compounds. WPE1-NB26 cells were more sensitive to phenethyl isothiocyanate and tumor necrosis factor (TNF than RWPE1 cells, while PC3 cells were more sensitive to TNF than PrEC cells. These results are consistent with the hypothesis that cancer cell redox state may modulate responses to redox-modulating therapeutic regimens.

  10. Networks: structure and action : steering in and steering by policy networks

    NARCIS (Netherlands)

    Dassen, Adrie

    2010-01-01

    This thesis explores the opportunities to build a structural policy network model that is rooted in social network theories. By making a distinction between a process of steering in networks, and a process of steering by networks, it addresses the effects of network structures on network dynamics as

  11. Redox theory of aging

    Directory of Open Access Journals (Sweden)

    Dean P. Jones

    2015-08-01

    Full Text Available Metazoan genomes encode exposure memory systems to enhance survival and reproductive potential by providing mechanisms for an individual to adjust during lifespan to environmental resources and challenges. These systems are inherently redox networks, arising during evolution of complex systems with O2 as a major determinant of bioenergetics, metabolic and structural organization, defense, and reproduction. The network structure decreases flexibility from conception onward due to differentiation and cumulative responses to environment (exposome. The redox theory of aging is that aging is a decline in plasticity of genome–exposome interaction that occurs as a consequence of execution of differentiation and exposure memory systems. This includes compromised mitochondrial and bioenergetic flexibility, impaired food utilization and metabolic homeostasis, decreased barrier and defense capabilities and loss of reproductive fidelity and fecundity. This theory accounts for hallmarks of aging, including failure to maintain oxidative or xenobiotic defenses, mitochondrial integrity, proteostasis, barrier structures, DNA repair, telomeres, immune function, metabolic regulation and regenerative capacity.

  12. Ediacaran Redox Fluctuations

    Science.gov (United States)

    Sahoo, S. K.; Jiang, G.; Planavsky, N. J.; Kendall, B.; Owens, J. D.; Anbar, A. D.; Lyons, T. W.

    2013-12-01

    Evidence for pervasive oxic conditions, and likely even deep ocean oxygenation has been documented at three intervals in the lower (ca. 632 Ma), middle (ca. 580 Ma) and upper (ca. 551 Ma) Ediacaran. The Doushantuo Formation in South China hosts large enrichments of redox-sensitive trace element (e.g., molybdenum, vanadium and uranium) in anoxic shales, which are indicative of a globally oxic ocean-atmosphere system. However, ocean redox conditions between these periods continue to be a topic of debate and remain elusive. We have found evidence for widespread anoxic conditions through much of the Ediacaran in the deep-water Wuhe section in South China. During most of the Ediacaran-early Cambrian in basinal sections is characterized by Fe speciation data and pyrite morphologies that indicate deposition under euxinic conditions with near-crustal enrichments of redox-sensitive element and positive pyrite-sulfur isotope values, which suggest low levels of marine sulfate and widespread euxinia. Our work reinforces an emerging view that the early Earth, including the Ediacaran, underwent numerous rises and falls in surface oxidation state, rather than a unidirectional rise as originally imagined. The Ediacaran ocean thus experienced repetitive expansion and contraction of marine chalcophilic trace-metal levels that may have had fundamental impact on the slow evolution of early animals and ecosystems. Further, this framework forces us to re-examine the relationship between Neoproterozoic oxygenation and metazoan diversification. Varying redox conditions through the Cryogenian and Ediacaran may help explain molecular clock and biomarker evidence for an early appearance and initial diversification of metazoans but with a delay in the appearance of most major metazoan crown groups until close to Ediacaran-Cambrian boundary.

  13. Sarsaparilla (Smilax Glabra Rhizome) Extract Inhibits Cancer Cell Growth by S Phase Arrest, Apoptosis, and Autophagy via Redox-Dependent ERK1/2 Pathway.

    Science.gov (United States)

    She, Tiantian; Qu, Like; Wang, Lixin; Yang, Xingxin; Xu, Shuo; Feng, Junnan; Gao, Yujing; Zhao, Chuanke; Han, Yong; Cai, Shaoqing; Shou, Chengchao

    2015-05-01

    Cancer is still the major cause of death across the world. Regular approaches cannot effectively solve the emerging problems, including drug/radiation resistance, side effects, and therapeutic ineffectiveness. Natural dietary supplements have shown effectiveness in the prevention and treatment of cancer. Sarsaparilla (Smilax Glabra Rhizome) has growth-inhibitory effects on several cancer cell lines in vitro and in vivo, with little toxicity on normal cells. However, the mechanism underlying its function remains elusive. In the present study, we examined the anticancer activity of the supernatant of the water-soluble extract (SW) from sarsaparilla. Liquid chromatography/mass spectrometry-ion trap-time-of-flight (LC/MS-IT-TOF) analysis identified flavonoids, alkaloids, and phenylpropanoids as the major bioactive components of SW. SW was shown to markedly inhibit the growth of a broad spectrum of cancer cell lines in the in vitro and in vivo assays. S phase arrest, autophagy, or/and apoptosis were partly responsible for SW-induced growth inhibition. Results of microarray analysis and validation by quantitative RT-PCR indicated the involvement of oxidative stress and the MAPK1 pathway in SW-treated cells. We further found that SW destroyed intracellular-reduced glutathione/oxidized glutathione (GSH/GSSG) balance, and supplement with N-acetylcysteine (NAC) or glutathione (GSH) significantly antagonized SW-induced S phase arrest, apoptosis, and autophagy. In addition, SW-induced GSH/GSSG imbalance activated the ERK1/2 pathway, which contributed to SW-induced S phase arrest, apoptosis, autophagy, and resultant growth-inhibitory effect. Together, our results provide a molecular basis for sarsaparilla as an anticancer agent. PMID:25732255

  14. Effect of 3-bromopyruvate acid on the redox equilibrium in non-invasive MCF-7 and invasive MDA-MB-231 breast cancer cells.

    Science.gov (United States)

    Kwiatkowska, Ewa; Wojtala, Martyna; Gajewska, Agnieszka; Soszyński, Mirosław; Bartosz, Grzegorz; Sadowska-Bartosz, Izabela

    2016-02-01

    Novel approaches to cancer chemotherapy employ metabolic differences between normal and tumor cells, including the high dependence of cancer cells on glycolysis ("Warburg effect"). 3-Bromopyruvate (3-BP), inhibitor of glycolysis, belongs to anticancer drugs basing on this principle. 3-BP was tested for its capacity to kill human non-invasive MCF-7 and invasive MDA-MB-231 breast cancer cells. We found that 3-BP was more toxic for MDA-MB-231 cells than for MCF-7 cells. In both cell lines, a statistically significant decrease of ATP and glutathione was observed in a time- and 3-BP concentration-dependent manner. Transient increases in the level of reactive oxygen species and reactive oxygen species was observed, more pronounced in MCF-7 cells, followed by a decreasing tendency. Activities of glutathione peroxidase, glutathione reductase (GR) and glutathione S-transferase (GST) decreased in 3-BP treated MDA-MB-231 cells. For MCF-7 cells decreases of GR and GST activities were noted only at the highest concentration of 3-BP.These results point to induction of oxidative stress by 3-BP via depletion of antioxidants and inactivation of antioxidant enzymes, more pronounced in MDA-MB-231 cells, more sensitive to 3-BP. PMID:26715289

  15. Aeroelastic Tailoring via Tow Steered Composites

    Science.gov (United States)

    Stanford, Bret K.; Jutte, Christine V.

    2014-01-01

    The use of tow steered composites, where fibers follow prescribed curvilinear paths within a laminate, can improve upon existing capabilities related to aeroelastic tailoring of wing structures, though this tailoring method has received relatively little attention in the literature. This paper demonstrates the technique for both a simple cantilevered plate in low-speed flow, as well as the wing box of a full-scale high aspect ratio transport configuration. Static aeroelastic stresses and dynamic flutter boundaries are obtained for both cases. The impact of various tailoring choices upon the aeroelastic performance is quantified: curvilinear fiber steering versus straight fiber steering, certifiable versus noncertifiable stacking sequences, a single uniform laminate per wing skin versus multiple laminates, and identical upper and lower wing skins structures versus individual tailoring.

  16. Multipass Steering Protocols at Jefferson Lab

    International Nuclear Information System (INIS)

    The CEBAF recirculating accelerator consists of two CW superconducting RF linacs, through which an electron beam is accelerated for up to 5 passes. Focusing and steering elements affect each pass differently, requiring a multipass steering protocol to correct the orbits. Perturbations include lens misalignments (including long-term ground motion), BPM offsets, and focusing and steering from RF fields inside the cavities. A previous treatment of this problem assumed all perturbations were localized at the quadrupoles and the absence of x-y coupling. Having analyzed the problem and characterized the solutions, we developed an empirical iterative protocol to compare against previous results in the presence of skew fields and cross-plane coupling. We plan to characterize static and acceleration-dependent components of the beam line perturbations to allow systematic and rapid configuration of the accelerator at different linac energy gains

  17. A computer algorithm for automatic beam steering

    Energy Technology Data Exchange (ETDEWEB)

    Drennan, E.

    1992-06-01

    Beam steering is done by modifying the current in a trim or bending magnet. If the current change is the right amount the beam can be made to bend in such a manner that it will hit a swic or BPM downstream from the magnet at a predetermined set point. Although both bending magnets and trim magnets can be used to modify beam angle, beam steering is usually done with trim magnets. This is so because, during beam steering the beam angle is usually modified only by a small amount which can be easily achieved with a trim magnet. Thus in this note, all steering magnets will be assumed to be trim magnets. There are two ways of monitoring beam position. One way is done using a BPM and the other is done using a swic. For simplicity, beam position monitoring in this paper will be referred to being done with a swic. Beam steering can be done manually by changing the current through a trim magnet and monitoring the position of the beam downstream from the magnet with a swic. Alternatively the beam can be positioned automatically using a computer which periodically updates the current through a specific number of trim magnets. The purpose of this note is to describe the steps involved in coming up with such a computer program. There are two main aspects to automatic beam steering. First a relationship between the beam position and the bending magnet is needed. Secondly a beamline setup of swics and trim magnets has to be chosen that will position the beam according to the desired specifications. A simple example will be looked at that will show that once a mathematical relationship between the needed change of the beam position on a swic and the change in trim currents is established, a computer could be programmed to calculate and update the trim currents.

  18. Experimental Quantification of Asymmetric Einstein-Podolsky-Rosen Steering.

    Science.gov (United States)

    Sun, Kai; Ye, Xiang-Jun; Xu, Jin-Shi; Xu, Xiao-Ye; Tang, Jian-Shun; Wu, Yu-Chun; Chen, Jing-Ling; Li, Chuan-Feng; Guo, Guang-Can

    2016-04-22

    Einstein-Podolsky-Rosen (EPR) steering describes the ability of one observer to nonlocally "steer" the other observer's state through local measurements. EPR steering exhibits a unique asymmetric property; i.e., the steerability can differ between observers, which can lead to one-way EPR steering in which only one observer obtains steerability in the steering process. This property is inherently different from the symmetric concepts of entanglement and Bell nonlocality, and it has attracted increasing interest. Here, we experimentally demonstrate asymmetric EPR steering for a class of two-qubit states in the case of two measurement settings. We propose a practical method to quantify the steerability. We then provide a necessary and sufficient condition for EPR steering and clearly demonstrate one-way EPR steering. Our work provides new insight into the fundamental asymmetry of quantum nonlocality and has potential applications in asymmetric quantum information processing. PMID:27152778

  19. 46 CFR 182.620 - Auxiliary means of steering.

    Science.gov (United States)

    2010-10-01

    ... TONS) MACHINERY INSTALLATION Steering Systems § 182.620 Auxiliary means of steering. (a) Except as... personnel hazards during normal or heavy weather operation. (b) A suitable hand tiller may be acceptable...

  20. Experimental Quantification of Asymmetric Einstein-Podolsky-Rosen Steering

    Science.gov (United States)

    Sun, Kai; Ye, Xiang-Jun; Xu, Jin-Shi; Xu, Xiao-Ye; Tang, Jian-Shun; Wu, Yu-Chun; Chen, Jing-Ling; Li, Chuan-Feng; Guo, Guang-Can

    2016-04-01

    Einstein-Podolsky-Rosen (EPR) steering describes the ability of one observer to nonlocally "steer" the other observer's state through local measurements. EPR steering exhibits a unique asymmetric property; i.e., the steerability can differ between observers, which can lead to one-way EPR steering in which only one observer obtains steerability in the steering process. This property is inherently different from the symmetric concepts of entanglement and Bell nonlocality, and it has attracted increasing interest. Here, we experimentally demonstrate asymmetric EPR steering for a class of two-qubit states in the case of two measurement settings. We propose a practical method to quantify the steerability. We then provide a necessary and sufficient condition for EPR steering and clearly demonstrate one-way EPR steering. Our work provides new insight into the fundamental asymmetry of quantum nonlocality and has potential applications in asymmetric quantum information processing.

  1. A steering mechanism for phototaxis in Chlamydomonas

    CERN Document Server

    Bennett, Rachel R

    2014-01-01

    Chlamydomonas shows both positive and negative phototaxis. It has a single eyespot near its equator and as the cell rotates during forward motion the light signal received by the eyespot varies. We use a simple mechanical model of Chlamydomonas that couples the flagellar beat pattern to the light intensity at the eyespot to demonstrate a mechanism for phototactic steering that is consistent with observations. The direction of phototaxis is controlled by a parameter in our model and the steering mechanism is robust to noise. Our model shows switching between directed phototaxis when the light is on and run-and-tumble behaviour in the dark.

  2. THz beam steering by optical coherent control

    CERN Document Server

    Füser, Heiko

    2013-01-01

    We demonstrate optical coherent control of the emission direction of THz radiation. Femtosecond laser pulses are used to excite different types of ultrafast photocurrents along different directions in a bulk GaAs sample. The overall emission pattern can be modified by changing the phase of the optical excitation. With this method, THz beam steering of about 8 degrees is realized. A simple dipole-based model allows us to relate the size of the steering effect to the amplitude ratio between the different photocurrent contributions and to diffraction effects resulting from the excitation spot size.

  3. More About Beam-Steering Subsystem For Laser Communication

    Science.gov (United States)

    Page, Norman A.; Chen, Chien-Chu; Hemmati, Hamid; Lesh, James R.

    1995-01-01

    Two reports present additional information about developmental beam-steering subsystem of laser-communication system. Aspects of this subsystem described previously in "Beam-Steering Subsystem for Laser Communication" (NPO-19069) and "Digital Controller for Laser-Beam-Steering Subsystem" (NPO-19193). Reports reiterate basic principles of operation of beam-steering subsystem and of laser-communication system as whole. Also presents some of details of optical and mechanical design of prototype of subsystem, called Optical Communication Demonstrator.

  4. 46 CFR 167.65-25 - Steering gear tests.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Steering gear tests. 167.65-25 Section 167.65-25... SHIPS Special Operating Requirements § 167.65-25 Steering gear tests. On all nautical school ships making voyages of more than 48 hours' duration, the entire steering gear, the whistle, the means...

  5. 46 CFR 61.20-1 - Steering gear.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Steering gear. 61.20-1 Section 61.20-1 Shipping COAST... Periodic Tests of Machinery and Equipment § 61.20-1 Steering gear. (a) The marine inspector must inspect the steering gear at each inspection for certification for vessels whose Certificate of...

  6. 9 CFR 78.21 - Bison steers and spayed heifers.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Bison steers and spayed heifers. 78.21... Restrictions on Interstate Movement of Bison Because of Brucellosis § 78.21 Bison steers and spayed heifers. Bison steers and spayed heifers may be moved interstate without restriction under this subpart....

  7. 9 CFR 78.6 - Steers and spayed heifers.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Steers and spayed heifers. 78.6... Restrictions on Interstate Movement of Cattle Because of Brucellosis § 78.6 Steers and spayed heifers. Steers and spayed heifers may be moved interstate without restriction under this subpart....

  8. Digital Controller For Laser-Beam-Steering Subsystem

    Science.gov (United States)

    Ansari, Homayoon

    1995-01-01

    Report presents additional information about proposed apparatus described in "Beam-Steering Subsystem for Laser Communication" (NPO-19069). Discusses design of digital beam-steering control subsystem and, in particular, that part of design pertaining to digital compensation for frequency response of steering mirror.

  9. Speed choice and steering behavior in curve driving

    NARCIS (Netherlands)

    van Winsum, W.; Godthelp, J

    1996-01-01

    The relation between speed choice and steering performance during curve negotiation was studied in a driving simulator. The hypothesis was that curve radius and steering competence both affect steering error during curve driving, resulting in compensatory speed choice. In this, the control of safety

  10. 14 CFR 23.745 - Nose/tail wheel steering.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Nose/tail wheel steering. 23.745 Section 23.745 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... Landing Gear § 23.745 Nose/tail wheel steering. (a) If nose/tail wheel steering is installed, it must...

  11. Enhancement of Selectivity of an Organometallic Anticancer Agent by Redox Modulation.

    Science.gov (United States)

    Romero-Canelón, Isolda; Mos, Magdalena; Sadler, Peter J

    2015-10-01

    Combination with redox modulators can potentiate the anticancer activity and maximize the selectivity of organometallic complexes with redox-based mechanisms of action. We show that nontoxic doses of l-buthionine sulfoximine increase the selectivity of organo-Os complex FY26 for human ovarian cancer cells versus normal lung fibroblasts to 63-fold. This increase is not due to changes in the mechanism of action of FY26 but to the decreased response of cancer cells to oxidative stress. PMID:26397305

  12. Ultramaneuverable steering control algorithms for terrain transitions

    Science.gov (United States)

    Torrie, Mel W.; Koch, Ralf; Bahl, Vikas; Cripps, Don

    1999-07-01

    The Center for Self-Organizing and Intelligent Systems has built several vehicles with ultra-maneuverable steering capability. Each drive wheel on the vehicle can be independently set at any angle with respect to the vehicle body and the vehicles can rotate or translate in any direction. The vehicles are expected to operate on a wide range of terrain surfaces and problems arise in effectively controlling changes in wheel steering angles as the vehicle transitions from one extreme running surface to another. Controllers developed for smooth surfaces may not perform well on rough or 'sticky' surfaces and vice versa. The approach presented involves the development of a model of the steering motor with the static and viscous friction of the steering motor load included. The model parameters are then identified through a series of environmental tests using a vehicle wheel assembly and the model thus obtained is used for control law development. Four different robust controllers were developed and evaluated through simulation and vehicle testing. The findings of this development will be presented.

  13. Development of steering system in network environment

    International Nuclear Information System (INIS)

    We have been developing the steering system, which can successively observe the-data obtained during the numerical computation and change the parameters in the analysis. Moreover, this system is also extended to link the network. By using this system, a user can easily detect errors immediately and achieve the rapid and accurate analysis with lower computation cost. (Author)

  14. Beam-Steering Subsystem For Laser Communication

    Science.gov (United States)

    Lesh, James R.; Chen, Chien-Chung; Ansari, Homayoon

    1995-01-01

    Proposed free-space laser communication system contains fewer optical and mechanical components. Involves novel fast beam-steering subsystem stabilizing only angle between transmitting and receiving beams instead of stabilizing both transmitting and receiving lines of sight individually. Received and transmitted beams of light both imaged onto CCD array at focal plane. Relative angular positions of beams computed from centroids of their images.

  15. Parametrizable cameras for 3D computational steering

    NARCIS (Netherlands)

    Mulder, J.D.; Wijk, J.J. van

    1997-01-01

    We present a method for the definition of multiple views in 3D interfaces for computational steering. The method uses the concept of a point-based parametrizable camera object. This concept enables a user to create and configure multiple views on his custom 3D interface in an intuitive graphical man

  16. Steered wheel for the support and/or steering of a vehicle, particularly hovercraft

    Energy Technology Data Exchange (ETDEWEB)

    Duell, H.J.; Kirchner, G.

    1977-04-07

    The invention concerns a steered wheel for the support or steering of a hovercraft, whose wheel suspension is provided with an eccentric journal for automatic setting in the direction of travel. So that the vehicle will not leave its track during changes of direction when the wheel is turned around the eccentric axis, according to the invention the wheel is supported on movable bearings at the journal in the direction of the driving axle.

  17. Exercise training combined with antioxidant supplementation prevents the antiproliferative activity of their single treatment in prostate cancer through inhibition of redox adaptation.

    Science.gov (United States)

    Gueritat, Jordan; Lefeuvre-Orfila, Luz; Vincent, Sophie; Cretual, Armel; Ravanat, Jean-Luc; Gratas-Delamarche, Arlette; Rannou-Bekono, Françoise; Rebillard, Amélie

    2014-12-01

    In preclinical models, exercise training (ET) or pomegranate juice (PJ) prevents prostate cancer progression. Here, we hypothesized that physical exercise combined with antioxidants could induce synergistic effects through oxidative stress modulation. Forty male Copenhagen rats with prostate tumors were divided into four groups: control, PJ, ET, and PJ+ET. Rats from the PJ group consumed 750 µl of PJ daily, rats from the ET group ran on a treadmill 5 days per week, and PJ+ET rats received the combined treatment. Each week, tumor growth was evaluated. After 4 weeks of treatment, the rats were euthanized and blood, muscles, and tumors were collected. Tumor Ki67, extracellular signal-regulated kinase (ERK) activation, Bcl-2 expression, and enzymatic and nonenzymatic antioxidant defenses, as well as oxidative stress markers (oxidized base, lipid peroxidation, protein carbonylation), were measured. PJ or ET significantly decreased prostate tumor proliferation (Ki67 staining, pcancer progression. PJ significantly reduced Bcl-2 expression in tumors (peffect. PJ or ET increased enzymatic antioxidant defenses in muscle, PJ increased nonenzymatic antioxidant defenses in plasma and whole blood. In addition, PJ reduced TBARS and 8-oxodGuo levels in tumors as well as ET (pcancer cells with antioxidants blunts the positive effects of ET and interferes with important reactive oxygen species-mediated physiological processes such as antioxidant adaptations. PMID:25236740

  18. Improving Einstein–Podolsky–Rosen steering inequalities with state information

    International Nuclear Information System (INIS)

    We discuss the relationship between entropic Einstein–Podolsky–Rosen (EPR)-steering inequalities and their underlying uncertainty relations along with the hypothesis that improved uncertainty relations lead to tighter EPR-steering inequalities. In particular, we discuss how using information about the state of a quantum system affects one's ability to witness EPR-steering. As an example, we consider the recent improvement to the entropic uncertainty relation between pairs of discrete observables (Berta et al., 2010 [10]). By considering the assumptions that enter into the development of a steering inequality, we derive correct steering inequalities from these improved uncertainty relations and find that they are identical to ones already developed (Schneeloch et al., 2013 [9]). In addition, we consider how one can use state information to improve our ability to witness EPR-steering, and develop a new continuous variable symmetric EPR-steering inequality as a result.

  19. The Tumorigenic Roles of the Cellular REDOX Regulatory Systems

    Science.gov (United States)

    Castaldo, Stéphanie Anaís; Freitas, Joana Raquel; Conchinha, Nadine Vasconcelos; Madureira, Patrícia Alexandra

    2016-01-01

    The cellular REDOX regulatory systems play a central role in maintaining REDOX homeostasis that is crucial for cell integrity, survival, and proliferation. To date, a substantial amount of data has demonstrated that cancer cells typically undergo increasing oxidative stress as the tumor develops, upregulating these important antioxidant systems in order to survive, proliferate, and metastasize under these extreme oxidative stress conditions. Since a large number of chemotherapeutic agents currently used in the clinic rely on the induction of ROS overload or change of ROS quality to kill the tumor, the cancer cell REDOX adaptation represents a significant obstacle to conventional chemotherapy. In this review we will first examine the different factors that contribute to the enhanced oxidative stress generally observed within the tumor microenvironment. We will then make a comprehensive assessment of the current literature regarding the main antioxidant proteins and systems that have been shown to be positively associated with tumor progression and chemoresistance. Finally we will make an analysis of commonly used chemotherapeutic drugs that induce ROS. The current knowledge of cancer cell REDOX adaptation raises the issue of developing novel and more effective therapies for these tumors that are usually resistant to conventional ROS inducing chemotherapy. PMID:26682014

  20. The Tumorigenic Roles of the Cellular REDOX Regulatory Systems.

    Science.gov (United States)

    Castaldo, Stéphanie Anaís; Freitas, Joana Raquel; Conchinha, Nadine Vasconcelos; Madureira, Patrícia Alexandra

    2016-01-01

    The cellular REDOX regulatory systems play a central role in maintaining REDOX homeostasis that is crucial for cell integrity, survival, and proliferation. To date, a substantial amount of data has demonstrated that cancer cells typically undergo increasing oxidative stress as the tumor develops, upregulating these important antioxidant systems in order to survive, proliferate, and metastasize under these extreme oxidative stress conditions. Since a large number of chemotherapeutic agents currently used in the clinic rely on the induction of ROS overload or change of ROS quality to kill the tumor, the cancer cell REDOX adaptation represents a significant obstacle to conventional chemotherapy. In this review we will first examine the different factors that contribute to the enhanced oxidative stress generally observed within the tumor microenvironment. We will then make a comprehensive assessment of the current literature regarding the main antioxidant proteins and systems that have been shown to be positively associated with tumor progression and chemoresistance. Finally we will make an analysis of commonly used chemotherapeutic drugs that induce ROS. The current knowledge of cancer cell REDOX adaptation raises the issue of developing novel and more effective therapies for these tumors that are usually resistant to conventional ROS inducing chemotherapy. PMID:26682014

  1. The Tumorigenic Roles of the Cellular REDOX Regulatory Systems

    Directory of Open Access Journals (Sweden)

    Stéphanie Anaís Castaldo

    2016-01-01

    Full Text Available The cellular REDOX regulatory systems play a central role in maintaining REDOX homeostasis that is crucial for cell integrity, survival, and proliferation. To date, a substantial amount of data has demonstrated that cancer cells typically undergo increasing oxidative stress as the tumor develops, upregulating these important antioxidant systems in order to survive, proliferate, and metastasize under these extreme oxidative stress conditions. Since a large number of chemotherapeutic agents currently used in the clinic rely on the induction of ROS overload or change of ROS quality to kill the tumor, the cancer cell REDOX adaptation represents a significant obstacle to conventional chemotherapy. In this review we will first examine the different factors that contribute to the enhanced oxidative stress generally observed within the tumor microenvironment. We will then make a comprehensive assessment of the current literature regarding the main antioxidant proteins and systems that have been shown to be positively associated with tumor progression and chemoresistance. Finally we will make an analysis of commonly used chemotherapeutic drugs that induce ROS. The current knowledge of cancer cell REDOX adaptation raises the issue of developing novel and more effective therapies for these tumors that are usually resistant to conventional ROS inducing chemotherapy.

  2. Research on Torque Ratio Based on the Steering Wheel Torque Characteristic for Steer-by-Wire System

    Directory of Open Access Journals (Sweden)

    Yandong Han

    2014-01-01

    Full Text Available Steer-by-wire system can improve the performance of vehicle handling stability. Removing the mechanical linkages between the front wheels and the steering wheel leads to a key technique of force feedback for steer-by-wire system. In view of the characteristic of variable torque transmission ratio for steer-by-wire system, this paper proposes a method for designing torque ratio based on the steering wheel torque characteristic for steer-by-wire system. It converts the torque ratio design into equivalent assist torque design by analyzing their relationship. It achieves the torque ratio design at different conditions based on the negative equivalent assist torque characteristic curve. Simulations and vehicle experiments are conducted by the proposed method, and the results show that the design goal has been achieved and the steering wheel torque characteristic obtained is very similar to that of the reference car.

  3. ACTIVE FRONT STEERING DURING BRAKING PROCESS

    Institute of Scientific and Technical Information of China (English)

    CHEN Deling; CHEN Li; YIN Chengliang; ZHANG Yong

    2008-01-01

    An active front steering (AFS) intervention control during braking for vehicle stability is presented. Based on the investigation of AFS mechanism, a simplified model of steering system is established and integrated with vehicle model. Then the AFS control on vehicle handling dynamics during braking is designed. Due to the difficulties associated with the sideslip angle measurement of vehicle, a state observer is designed to provide real time estimation. Thereafter, the controller with the feedback of both sideslip and yaw angle is implemented. To evaluate the system control, the proposed AFS controlled vehicle has been tested in the Hardware-in-the-loop-simulation (HILS) system and compared with that of conventional vehicle. Results show that AFS can improve vehicle lateral stability effectively without reducing the braking performance.

  4. Steering magnetic micropropellers along independent trajectories

    International Nuclear Information System (INIS)

    Multi-microrobot control is highly promising for the assembly of matter on the microscale, in situ sensing, targeted drug delivery or nanosurgery. Magnetic micropropellers can be powered and steered by external magnetic fields and therefore represent a promising microrobotic actuation mechanism. However, the simultaneous actuation of multiple propellers along independent trajectories has yet to be realized. This is challenging, specifically because all propellers are steered by the same fields. We identify here an optimal control strategy based on a thorough theoretical analysis of multi-microrobot control. Based on analytical results and simulations, we estimate the limitations to the achievable control precisions due to diffusion, errors in the field application, and interactions between propellers. We find that control precisions of a few micrometers might be achievable. (paper)

  5. Pointing Device Performance in Steering Tasks.

    Science.gov (United States)

    Senanayake, Ransalu; Goonetilleke, Ravindra S

    2016-06-01

    Use of touch-screen-based interactions is growing rapidly. Hence, knowing the maneuvering efficacy of touch screens relative to other pointing devices is of great importance in the context of graphical user interfaces. Movement time, accuracy, and user preferences of four pointing device settings were evaluated on a computer with 14 participants aged 20.1 ± 3.13 years. It was found that, depending on the difficulty of the task, the optimal settings differ for ballistic and visual control tasks. With a touch screen, resting the arm increased movement time for steering tasks. When both performance and comfort are considered, whether to use a mouse or a touch screen for person-computer interaction depends on the steering difficulty. Hence, a input device should be chosen based on the application, and should be optimized to match the graphical user interface. PMID:27216944

  6. A steering mechanism for phototaxis in Chlamydomonas

    Science.gov (United States)

    Bennett, Rachel; Golestanian, Ramin

    2015-03-01

    Chlamydomonas shows both positive and negative phototaxis. It has a single eyespot near its equator and as the cell rotates during forward motion the light signal received by the eyespot varies. We use a simple mechanical model of Chlamydomonas that couples the flagellar beat pattern to the light intensity at the eyespot to demonstrate a mechanism for phototactic steering that is consistent with observations. The direction of phototaxis is controlled by a parameter in our model and the steering mechanism is robust to noise. In the dark, our model shows emergent run-and-tumble behavior and we see switching between directed phototaxis and run-and-tumble when we switch the light on and off.

  7. SPS Beam Steering for LHC Extraction

    CERN Document Server

    Gianfelice Wendt, E; Cornelis, K; Norderhaug Drosdal, L; Goddard, B; Kain, V; Meddahi, M; Papaphilippou, Y; Wenninger, J

    2014-01-01

    Beside producing beams for fixed target operation, the CERN Super Proton Synchrotron (SPS) accelerates beams for injection into the Large Hadron Collider (LHC). During the 2012-2013 run drifts of the extracted beam horizontal trajectories have been observed and lengthy optimizations in the transfer lines were performed to reduce particle losses. The observed trajectory drifts are consistent with the measured SPS orbit drifts at extraction. The feasibility of an automatic beam steering towards a “golden” orbit at the extraction septa, has been therefore investigated. The challenges and constraints related to the implementation of such a correction in the SPS are described. Simulation results are presented and a possible operational steering strategy is proposed. As the observed drift is mainly horizontal, the horizontal plane only will be considered.

  8. Indexing system for optical beam steering

    Science.gov (United States)

    Sullivan, Mark T.; Cannon, David M.; Debra, Daniel B.; Young, Jeffrey A.; Mansfield, Joseph A.; Carmichael, Roger E.; Lissol, Peter S.; Pryor, G. M.; Miklosy, Les G.; Lee, Jeffrey H.

    1990-01-01

    This paper describes the design and testing of an indexing system for optical-beam steering. The cryogenic beam-steering mechanism is a 360-degree rotation device capable of discrete, high-precision alignment positions. It uses low-precision components for its rough alignment and kinematic design to meet its stringent repeatability and stability requirements (of about 5 arcsec). The principal advantages of this design include a decoupling of the low-precision, large angular motion from the high-precision alignment, and a power-off alignment position that potentially extends the life or hold time of cryogenic systems. An alternate design, which takes advantage of these attributes while reducing overall motion, is also presented. Preliminary test results show the kinematic mount capable of sub-arc second repeatability.

  9. EPR Steering inequalities with Communication Assistance

    Science.gov (United States)

    Nagy, Sándor; Vértesi, Tamás

    2016-01-01

    In this paper, we investigate the communication cost of reproducing Einstein-Podolsky-Rosen (EPR) steering correlations arising from bipartite quantum systems. We characterize the set of bipartite quantum states which admits a local hidden state model augmented with c bits of classical communication from an untrusted party (Alice) to a trusted party (Bob). In case of one bit of information (c = 1), we show that this set has a nontrivial intersection with the sets admitting a local hidden state and a local hidden variables model for projective measurements. On the other hand, we find that an infinite amount of classical communication is required from an untrusted Alice to a trusted Bob to simulate the EPR steering correlations produced by a two-qubit maximally entangled state. It is conjectured that a state-of-the-art quantum experiment would be able to falsify two bits of communication this way. PMID:26880376

  10. Steering System Vibration : Information and Perception Enhancement

    OpenAIRE

    Giacomin, J; Woo, Y. J.

    2005-01-01

    Automobile drivers are regularly exposed to vibrational and acoustic stimuli. These stimuli cause discomfort, and methods for analysing the noise, vibration and harshness (NVH) properties of automobiles are in regular use. Most manufacturers currently dedicate significant attention to the NVH characteristics of their products. NVH criteria are regularly applied to the design of the steering system, whose vibration spectra can reach frequencies as high as 300 Hz. The design of s...

  11. Self-testing through EPR-steering

    Science.gov (United States)

    Šupić, Ivan; Hoban, Matty J.

    2016-07-01

    The verification of quantum devices is an important aspect of quantum information, especially with the emergence of more advanced experimental implementations of quantum computation and secure communication. Within this, the theory of device-independent robust self-testing via Bell tests has reached a level of maturity now that many quantum states and measurements can be verified without direct access to the quantum systems: interaction with the devices is solely classical. However, the requirements for this robust level of verification are daunting and require high levels of experimental accuracy. In this paper we discuss the possibility of self-testing where we only have direct access to one part of the quantum device. This motivates the study of self-testing via EPR-steering, an intermediate form of entanglement verification between full state tomography and Bell tests. Quantum non-locality implies EPR-steering so results in the former can apply in the latter, but we ask what advantages may be gleaned from the latter over the former given that one can do partial state tomography? We show that in the case of self-testing a maximally entangled two-qubit state, or ebit, EPR-steering allows for simpler analysis and better error tolerance than in the case of full device-independence. On the other hand, this improvement is only a constant improvement and (up to constants) is the best one can hope for. Finally, we indicate that the main advantage in self-testing based on EPR-steering could be in the case of self-testing multi-partite quantum states and measurements. For example, it may be easier to establish a tensor product structure for a particular party’s Hilbert space even if we do not have access to their part of the global quantum system.

  12. TRANSFERRING OF MOVEMENT FOR STEERING EQUIPMENT

    OpenAIRE

    Outhier, Maxime; Rydström, Vilhelm; Sanz, Imanol

    2001-01-01

    This Examination Thesis was done at the Blekinge Institute of Technology of Karlskrona. The work is a part of the education to Bachelor of Science in product development. The task consists of changing the steering wheel transmission of the DYNAPAC CA soil compactor machine made by Svedala Compaction Equipment AB. During the work we have followed the Fredy Olsson product development method. The work is divided in two parts: The Concept phase and The Primary Construction phase. In the Concept p...

  13. Stress indicators in steers at slaughtering

    OpenAIRE

    Zarrilli, A.; G. Marsico; Grimaldi, M.; S. Dimatteo; E. Micera

    2010-01-01

    This work aimed to assess the blood modifications of some slaughtering-linked stress hormones in cattle subject to butcher standardized procedures. The blood samples of 20 Limousine 12-13 months old steers have been collected before slaughtering, during lairage, and after stunning by captive bolt gun, during exsanguination. The plasma level of epinephrine, norepinephrine, cortisol and beta-endorphin have been assayed by EIA. The data indicate that catecholamines, cortisol and beta-endorphin d...

  14. Redox Properties of Free Radicals.

    Science.gov (United States)

    Neta, P.

    1981-01-01

    Describes pulse radiolysis as a useful means in studing one-electron redox potentials. This method allows the production of radicals and the determination of their concentration and rates of reaction. (CS)

  15. On the Feasibility of Dynamic Power Steering

    Energy Technology Data Exchange (ETDEWEB)

    Barker, Kevin J.; Kerbyson, Darren J.; Anger, Eric A.

    2014-11-16

    While high performance has always been the primary constraint behind large-scale system design, future systems will be built with increasing energy efficiency in mind. Mechanisms such as fine-grained power scaling and gating will provide tools to system-software and application developers to ensure the most efficient use of tightly constrained power budgets. Such approaches to-date have been focused on node level optimizations to impact overall system energy efficiency. In this work we introduce Dynamic Power Steering, in which power can be dynamically routed across a system to resources where it will be of most benefit and away from other resources to maintain a near-constant overall power budget. This, a higher level algorithmic approach to improving energy efficiency, considers the whole extent of a system being used by an application. It can be used for applications in which there is load imbalance that varies over its execution. Using two classes of applications, namely those that contain a wave front type processing, and a particle-in-cell, we quantify the benefit of Dynamic Power Steering for a variety of workload characteristics and derive some insight into the ways in which workload behavior affect Power Steering applicability.

  16. Redox meets protein trafficking.

    Science.gov (United States)

    Bölter, Bettina; Soll, Jürgen; Schwenkert, Serena

    2015-09-01

    After the engulfment of two prokaryotic organisms, the thus emerged eukaryotic cell needed to establish means of communication and signaling to properly integrate the acquired organelles into its metabolism. Regulatory mechanisms had to evolve to ensure that chloroplasts and mitochondria smoothly function in accordance with all other cellular processes. One essential process is the post-translational import of nuclear encoded organellar proteins, which needs to be adapted according to the requirements of the plant. The demand for protein import is constantly changing depending on varying environmental conditions, as well as external and internal stimuli or different developmental stages. Apart from long-term regulatory mechanisms such as transcriptional/translation control, possibilities for short-term acclimation are mandatory. To this end, protein import is integrated into the cellular redox network, utilizing the recognition of signals from within the organelles and modifying the efficiency of the translocon complexes. Thereby, cellular requirements can be communicated throughout the whole organism. This article is part of a Special Issue entitled: Chloroplast Biogenesis. PMID:25626173

  17. Bifunctional redox flow battery

    International Nuclear Information System (INIS)

    A new bifunctional redox flow battery (BRFB) system, V(III)/V(II)-L-cystine(O2), was systematically investigated by using different separators. It is shown that during charge, water transfer is significantly restricted with increasing the concentration of HBr when the Nafion 115 cation exchange membrane is employed. The same result can be obtained when the gas diffusion layer (GDL) hot-pressed separator is used. The organic electro-synthesis is directly correlated with the crossover of vanadium. When employing the anion exchange membrane, the electro-synthesis efficiency is over 96% due to a minimal crossover of vanadium. When the GDL hot-pressed separator is applied, the crossover of vanadium and water transfer are noticeably prevented and the electro-synthesis efficiency of over 99% is obtained. Those impurities such as vanadium ions and bromine can be eliminated through the purification of organic electro-synthesized products. The purified product is identified to be L-cysteic acid by IR spectrum. The BRFB shows a favorable discharge performance at a current density of 20 mA cm-2. Best discharge performance is achieved by using the GDL hot-pressed separator. The coulombic efficiency of 87% and energy efficiency of about 58% can be obtained. The cause of major energy losses is mainly associated with the cross-contamination of anodic and cathodic active electrolytes

  18. Developments in redox flow batteries

    OpenAIRE

    Tangirala, Ravichandra

    2011-01-01

    This thesis describes the investigation of the electrochemistry principles, technology, construction and composition of the electrode materials, electrolyte and additives used in redox flow batteries. The aim was to study a flow battery system with an appreciable working performance. The study explores and compares mainly three different redox flow battery technologies; all-vanadium, soluble lead-acid and a novel copper-lead dioxide flow batteries. The first system is based in sulfuric acid e...

  19. Redox and zinc signalling pathways converging on protein tyrosine phosphatases.

    Science.gov (United States)

    Bellomo, Elisa; Hogstrand, Christer; Maret, Wolfgang

    2014-10-01

    Zinc ions, though redox-inert, have either pro-antioxidant or pro-oxidant functions at critical junctures in redox metabolism and redox signalling. They are released from cells and in cells, e.g. from metallothionein, a protein that transduces redox signals into zinc signals (1). The released zinc ions inhibit enzymes such as protein tyrosine phosphatases (PTPs), key regulatory enzymes of cellular phosphorylation signalling. The Ki(Zn) value for inhibition of receptor PTPB is 21pM (2). The binding is about as tight as the binding of zinc to zinc metalloenzymes and suggests tonic zinc inhibition. PTP1-B (PTPN1), an enzyme regulating the insulin and leptin receptors and involved in cancer and diabetes pathobiochemistry, has a Ki(Zn) value of about 5nM (3). Zinc ions bind to the enzyme in the closed conformation when additional metal-binding ligands are brought into the vicinity of the active site. In contrast, redox reactions target cysteines in the active sites of PTPs in the open conformation. This work provides a molecular basis how hydrogen peroxide and free zinc ions generated by growth factor signalling stimulate phosphorylation signalling differentially. (Supported by the Biotechnology and Biological Sciences Research Council UK, grant BB/K001442/1.). PMID:26461422

  20. Oblique incidence effect on steering efficiency of liquid crystal polarization gratings used for optical phased array beam steering amplification

    Science.gov (United States)

    Xiangjie, Zhao; Jiazhu, Duan; Dayong, Zhang; Cangli, Liu; Yongquan, Luo

    2016-07-01

    A liquid crystal polarization grating (LCPG) is proposed that amplifies the steering angle of a liquid crystal optical phased array for non-mechanical beam steering, taking advantage of its high steering efficiency under normal incidence. However, oblique incidence may play an important role in the overall steering efficiency. The effect of oblique incidence on steering efficiency of a LCPG was analyzed by numerically solving the extended Jones matrix and considering propagation crosstalk. The results indicate that the outgoing laser beam is amplitude-modulated under the effect of oblique incidence and behaves as a sinusoidal-modulated amplitude grating, which diffracts certain energies to non-blazed orders. Over-oblique incidence may even eliminate the steering effect of the incident beam. The modulation depth of the induced amplitude grating was found to be proportional to the product of sinusoidal value of oblique incidence angle and the LC layer thickness, and inversely proportional to the periodic pitch length of the LCPG. Both in-plane incidence and out-of-plane incidence behave similarly to influence the steering efficiency. Finally, the overall steering efficiency for cascaded LCPGs was analyzed and a difference of up to 11 % steering efficiency can be induced between different LCPG configurations, even without considering the over-oblique incidence effect. Both the modulation depth and final steering efficiency can be optimized by varying the LC birefringence and layer thickness.

  1. Comparison of manual steering and steering via joystick of a flexible rhino endoscope.

    Science.gov (United States)

    Eckl, R; Gumprecht, J J; Strauss, G; Hofer, M; Dietz, A; Lueth, T C

    2010-01-01

    Flexible endoscopes are used in ENT surgery for examination tasks in cases wherever rigid endoscopes are unsuitable to reach certain positions in the nasal cavity. Until today they are steered by hand and no robotized system has been put into clinical practice. One qualification a robot manipulator system has to fulfill to be accepted is not to create new disadvantages compared to the conventional method in surgery. An important factor is the time needed to steer the new system compared to the time needed to steer the conventional system. In this article a robot manipulator system and an experiment are presented to compare the particular times test persons need to perform a certain task. This approach offers the possibility to benchmark the developed robot manipulator system and future systems for flexible rhino endoscopes. PMID:21096123

  2. Multipartite Gaussian steering: monogamy constraints and cryptographical applications

    CERN Document Server

    Xiang, Yu; Adesso, Gerardo; He, Qiongyi

    2016-01-01

    We derive laws for the distribution of quantum steering among different parties in multipartite Gaussian states under Gaussian measurements. We prove that a monogamy relation akin to the generalized Coffman-Kundu-Wootters inequality holds quantitatively for a recently introduced measure of Gaussian steering. We then define the residual Gaussian steering, stemming from the monogamy inequality, as an indicator of collective steering-type correlations. For pure three-mode Gaussian states, the residual acts a quantifier of genuine multipartite steering, and is interpreted operationally in terms of the guaranteed key rate in the task of secure quantum secret sharing. Optimal resource states for the latter protocol are identified, and their possible experimental implementation discussed. Our results pin down the role of multipartite steering for quantum communication.

  3. Gaussian quantum steering and its asymmetry in curved spacetime

    CERN Document Server

    Wang, Jieci; Jing, Jiliang; Fan, Heng

    2015-01-01

    We study Gaussian quantum steering and its asymmetry in the background of a Schwarzschild black hole. We present a Gaussian channel description of quantum state evolution under the influence of Hawking radiation. We find that thermal noise introduced by Hawking effect will destroy the steerability between an inertial observer Alice and an accelerated observer Bob who hovers outside an event horizon, while it generates steerability between Bob and a hypothetical observer Anti-Bob inside the event horizon. Besides, unlike entanglement behaviors in curved spacetime, here the steering from Alice to Bob suffers from a ``sudden death" and the steering from Anti-Bob to Bob appears a ``sudden birth" with the increasing of Hawking temperature. We also find that the Gaussian steering is always asymmetric and the maximum steering asymmetry can \\emph{ exceed} $\\ln 2$ in curved spacetime, which is quite different from the flat spacetime case [Phys. Rev. Lett. 114, 060403 (2015)] where the steering asymmetry can \\emph{neve...

  4. Hydrogen peroxide and central redox theory for aerobic life: A tribute to Helmut Sies: Scout, trailblazer, and redox pioneer.

    Science.gov (United States)

    Jones, Dean P

    2016-04-01

    When Rafael Radi and I wrote about Helmut Sies for the Redox Pioneer series, I was disappointed that the Editor restricted us to the use of "Pioneer" in the title. My view is that Helmut was always ahead of the pioneers: He was a scout discovering paths for exploration and a trailblazer developing strategies and methods for discovery. I have known him for nearly 40 years and greatly enjoyed his collegiality as well as brilliance in scientific scholarship. He made monumental contributions to 20th century physiological chemistry beginning with his first measurement of H2O2 in rat liver. While continuous H2O2 production is dogma today, the concept of H2O2 production in mammalian tissues was largely buried for half a century. He continued this leadership in research on oxidative stress, GSH, selenium, and singlet oxygen, during the timeframe when physiological chemistry and biochemistry transitioned to contemporary 21st century systems biology. His impact has been extensive in medical and health sciences, especially in nutrition, aging, toxicology and cancer. I briefly summarize my interactions with Helmut, stressing our work together on the redox code, a set of principles to link mitochondrial respiration, bioenergetics, H2O2 metabolism, redox signaling and redox proteomics into central redox theory. PMID:27095208

  5. ANTENNA ARRAY WITH ELECTRONIC BEAM STEERING FOR TELECOMMUNICATION APPLICATIONS

    OpenAIRE

    Ali Akbarian, Hadi; Volskiy, Vladimir; Vandenbosch, Guy

    2010-01-01

    Electronically controlled beam steering array antennas highly increase the performance of telecommunication links by improving the link budget. Moreover, digital (baseband) beam steering includes the possibility of having multiple beams simultaneously and of communicating with more than one user at the same time. The basics of digital beam forming are explained in this paper. A 1x2 prototype array with digital beam steering is introduced and measurement results are shown.

  6. Quantum steering: a short review with focus on semidefinite programming

    OpenAIRE

    D. Cavalcanti; Skrzypczyk, P.

    2016-01-01

    Quantum steering refers to a situation where two parties share a bipartite system onto which one of the parties applies measurements that changes the state of the other party in a way that can not be explained by classical means. Quantum steering has been interpreted as the task of entanglement detection in a one-sided device independent way and has received a lot of attention since then. Here we address the characterisation of quantum steering through semidefinite programming, including stee...

  7. Electric Power Controller for Steering Wheel Management in Electric Cars

    OpenAIRE

    Milanés, Vicente; Pérez Rastelli, Joshué; Onieva, Enrique; González, Carlos; Pedro, Teresa de

    2009-01-01

    International audience Driverless driving is one of the most interesting topics in the field of the intelligent transportation systems. Among these topics, the automation of the actuators involved in the management of a car, and out of them the control of the steering wheel constitute one of the most complex. In this paper, automatic power steering architecture to manage the steering wheel via Ethernet controller is developed. An on-board PC is connected to the controller to permit handlin...

  8. Compensation of low performance steering system using torque vectoring

    OpenAIRE

    Awan, M A

    2014-01-01

    In this work torque vectoring methods are used to compensate for a low performance steer-by-wire system. Currently a number of vehicle manufacturers are considering introducing steer-by-wire into their range of vehicles. Some of the key concerns for the manufacturers are safety and cost. The safety can be subdivided in the integrity of the steering system and the effect on handling. The focus of this study is the use of low cost steering actuators on a vehicle and identify its effect...

  9. Multi-axle dynamic steering system of truck-howitzer

    Institute of Scientific and Technical Information of China (English)

    Yanliang LI; Xiuhua GAO; Chunqiu ZHANG; Yubo SUN

    2008-01-01

    A two-degree-of-freedom (2-DOF) steering model of multi-axle vehicle was established. The steering center position, the relationship between the steering angle and the vehicle velocity, and the minimum turn radius were deduced on the basis of the proportional control with a zero sideslip angle. Results indicate that the system stability is decided by the vehicle barycenter position and the lateral stiffness of a tire. Under this control, the steady value of the lateral acceleration is obviously diminished and the yaw angular velocity changes little under any vehicle velocity. The system rapidly responds, the vehicle smoothly steers, and its handling stability is prominently improved.

  10. Adjusting inequalities for detection-loophole-free steering experiments

    OpenAIRE

    Sainz, Ana Belén; Guryanova, Yelena; McCutcheon, Will; Skrzypczyk, Paul

    2016-01-01

    We study the problem of certifying quantum steering in a detection-loophole-free manner in experimental situations that require post-selection. We present a method to find the modified local-hidden-state bound of steering inequalities in such a post-selected scenario. We then present a construction of linear steering inequalities in arbitrary finite dimension and show that they certify steering in a loophole-free manner as long as the detection efficiencies are above the known bound below whi...

  11. Fault-tolerant Actuator System for Electrical Steering of Vehicles

    DEFF Research Database (Denmark)

    Sørensen, Jesper Sandberg; Blanke, Mogens

    2006-01-01

    Being critical to the safety of vehicles, the steering system is required to maintain the vehicles ability to steer until it is brought to halt, should a fault occur. With electrical steering becoming a cost-effective candidate for electrical powered vehicles, a fault-tolerant architecture is...... needed that meets this requirement. This paper studies the fault-tolerance properties of an electrical steering system. It presents a fault-tolerant architecture where a dedicated AC motor design used in conjunction with cheap voltage measurements can ensure detection of all relevant faults in the...

  12. A designed redox-controlled caspase

    Energy Technology Data Exchange (ETDEWEB)

    Witkowski, Witold A.; Hardy, Jeanne A. (UMASS, Amherst)

    2011-09-15

    Caspases are a powerful class of cysteine proteases. Introduction of activated caspases in healthy or cancerous cells results in induction of apoptotic cell death. In this study, we have designed and characterized a version of caspase-7 that can be inactivated under oxidizing extracellular conditions and then reactivated under reducing intracellular conditions. This version of caspase-7 is allosterically inactivated when two of the substrate-binding loops are locked together via an engineered disulfide. When this disulfide is reduced, the protein regains its full function. The inactive loop-locked version of caspase-7 can be readily observed by immunoblotting and mass spectrometry. The reduced and reactivated form of the enzyme observed crystallographically is the first caspase-7 structure in which the substrate-binding groove is properly ordered even in the absence of an active-site ligand. In the reactivated structure, the catalytic-dyad cysteine-histidine are positioned 3.5 {angstrom} apart in an orientation that is capable of supporting catalysis. This redox-controlled version of caspase-7 is particularly well suited for targeted cell death in concert with redox-triggered delivery vehicles.

  13. Redox electrode materials for supercapatteries

    Science.gov (United States)

    Yu, Linpo; Chen, George Z.

    2016-09-01

    Redox electrode materials, including transition metal oxides and electronically conducting polymers, are capable of faradaic charge transfer reactions, and play important roles in most electrochemical energy storage devices, such as supercapacitor, battery and supercapattery. Batteries are often based on redox materials with low power capability and safety concerns in some cases. Supercapacitors, particularly those based on redox inactive materials, e.g. activated carbon, can offer high power output, but have relatively low energy capacity. Combining the merits of supercapacitor and battery into a hybrid, the supercapattery can possess energy as much as the battery and output a power almost as high as the supercapacitor. Redox electrode materials are essential in the supercapattery design. However, it is hard to utilise these materials easily because of their intrinsic characteristics, such as the low conductivity of metal oxides and the poor mechanical strength of conducting polymers. This article offers a brief introduction of redox electrode materials, the basics of supercapattery and its relationship with pseudocapacitors, and reviews selectively some recent progresses in the relevant research and development.

  14. Auto-steering apparatus and method

    Science.gov (United States)

    McKay, Mark D.; Anderson, Matthew O.

    2007-03-13

    A vehicular guidance method involves providing a user interface using which data can be input to establish a contour for a vehicle to follow, the user interface further configured to receive information from a differential global positioning system (DGPS), determining cross track and offset data using information received from the DGPS, generating control values, using at least vehicular kinematics, the cross track, and the offset data, and providing an output to control steering of the vehicle, using the control values, in a direction to follow the established contour while attempting to minimize the cross track and the offset data.

  15. Yaw control using rear wheel steering

    OpenAIRE

    Westbom, Daniel; Frejinger, Petter

    2002-01-01

    The purpose of this project is to continue the work on a vehicle model developed in ADAMS/Car and applied with the concept of ACM (Autonomous Corner Module). The project is divided up in two parts. The objective of the first part is to setup a co-simulation environment between ADAMS/Car and MATLAB/Simulink, and evaluate the vehicle model. In the second part a yaw controller is developed using only the rear wheel steering possibilities. The controller will be evaluated when it is applied on th...

  16. Grid-Oscillator Beam-Steering Array

    OpenAIRE

    Li, Shijie; Rutledge, David B.

    1994-01-01

    Recently Liao and York (see IEEE Trans. Microwave Theory Tech., vol.41, no.10, p.1810, 1993) showed that beam-steering can be achieved by detuning the end elements of a coupled-oscillator array. The advantage of this approach is that no phase shifters are required. Liao and York used a single line array of patch antennas. Here we report the results for a pair of 1×4 HEMT line-grid oscillators at 11 GHz. This array can scan from -6.5° to +5° by changing the bias

  17. Stress indicators in steers at slaughtering

    Directory of Open Access Journals (Sweden)

    A. Zarrilli

    2010-04-01

    Full Text Available This work aimed to assess the blood modifications of some slaughtering-linked stress hormones in cattle subject to butcher standardized procedures. The blood samples of 20 Limousine 12-13 months old steers have been collected before slaughtering, during lairage, and after stunning by captive bolt gun, during exsanguination. The plasma level of epinephrine, norepinephrine, cortisol and beta-endorphin have been assayed by EIA. The data indicate that catecholamines, cortisol and beta-endorphin did not significantly increase after stunning in these animals.

  18. Hydrogen peroxide – production, fate and role in redox signaling of tumor cells

    OpenAIRE

    Lennicke, Claudia; Rahn, Jette; Lichtenfels, Rudolf; Wessjohann, Ludger A; Seliger, Barbara

    2015-01-01

    Hydrogen peroxide (H2O2) is involved in various signal transduction pathways and cell fate decisions. The mechanism of the so called “redox signaling” includes the H2O2-mediated reversible oxidation of redox sensitive cysteine residues in enzymes and transcription factors thereby altering their activities. Depending on its intracellular concentration and localization, H2O2 exhibits either pro- or anti-apoptotic activities. In comparison to normal cells, cancer cells are characterized by an in...

  19. 33 CFR 164.39 - Steering gear: Foreign tankers.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Steering gear: Foreign tankers... (CONTINUED) PORTS AND WATERWAYS SAFETY NAVIGATION SAFETY REGULATIONS § 164.39 Steering gear: Foreign tankers. (a) This section applies to each foreign tanker of 10,000 gross tons or more, except a public...

  20. Dynamic two-dimensional beam-pattern steering technique

    Science.gov (United States)

    Zhou, Shaomin; Yeh, Pochi; Liu, Hua-Kuang

    1993-01-01

    A dynamic two-dimensional laser-beam-pattern steering technique using photorefractive holograms in conjunction with electrically addressed spatial light modulators is proposed and investigated. The experimental results demonstrate the dynamic steering of random combinations of basis beam patterns. The proposed method has the advantages of random beam-pattern combination, good beam intensity uniformity, and higher diffraction efficiency compared with conventional methods.

  1. Gaussian quantum steering and its asymmetry in curved spacetime

    Science.gov (United States)

    Wang, Jieci; Cao, Haixin; Jing, Jiliang; Fan, Heng

    2016-06-01

    We study Gaussian quantum steering and its asymmetry in the background of a Schwarzschild black hole. We present a Gaussian channel description of quantum state evolution under the influence of Hawking radiation. We find that thermal noise introduced by the Hawking effect will destroy the steerability between an inertial observer Alice and an accelerated observer Bob who hovers outside the event horizon, while it generates steerability between Bob and a hypothetical observer anti-Bob inside the event horizon. Unlike entanglement behaviors in curved spacetime, here the steering from Alice to Bob suffers from a "sudden death" and the steering from anti-Bob to Bob experiences a "sudden birth" with increasing Hawking temperature. We also find that the Gaussian steering is always asymmetric and the maximum steering asymmetry cannot exceed ln 2 , which means the state never evolves to an extremal asymmetry state. Furthermore, we obtain the parameter settings that maximize steering asymmetry and find that (i) s =arccosh cosh/2r 1 -sinh2r is the critical point of steering asymmetry and (ii) the attainment of maximal steering asymmetry indicates the transition between one-way steerability and both-way steerability for the two-mode Gaussian state under the influence of Hawking radiation.

  2. Thick Pixelated CZT Detectors With Isolated Steering Grids

    CERN Document Server

    Jung, I; Perkins, J S; Krawczynski, H; Matteson, J; Skelton, R T; Bürger, A; Groza, M

    2005-01-01

    We explore the possibility to improve the performance of 0.5 cm thick Cadmium Zinc Telluride (CZT) detectors with the help of steering grids on the anode side of the detectors. Steering grids can improve the energy resolution of CZT detectors by enhancing the small pixel effect; furthermore, they can increase their detection efficiency by steering electrons to the anode pixels which otherwise would drift to the area between pixels. Previously, the benefit of steering grids had been compromised by additional noise associated with currents between the steering grids and the anode pixels. We use thin film deposition techniques to isolate the steering grid from the CZT substrate by a 150 nm thick layer of the isolator Aluminiumoxide. While the thin layer does not affect the beneficial effect of the steering grid on the weighting potentials and the electric field inside the detector, it suppresses the currents between the steering grid and the anode pixels. In this contribution, we present first results from a 2 x...

  3. Visual analysis and steering of flooding simulations.

    Science.gov (United States)

    Ribičić, Hrvoje; Waser, Jürgen; Fuchs, Raphael; Blöschl, Günter; Gröller, Eduard

    2013-06-01

    We present a visualization tool for the real-time analysis of interactively steered ensemble-simulation runs, and apply it to flooding simulations. Simulations are performed on-the-fly, generating large quantities of data. The user wants to make sense of the data as it is created. The tool facilitates understanding of what happens in all scenarios, where important events occur, and how simulation runs are related. We combine different approaches to achieve this goal. To maintain an overview, data are aggregated and embedded into the simulation rendering, showing trends, outliers, and robustness. For a detailed view, we use information-visualization views and interactive visual analysis techniques. A selection mechanism connects the two approaches. Points of interest are selected by clicking on aggregates, supplying data for visual analysis. This allows the user to maintain an overview of the ensemble and perform analysis even as new data are supplied through simulation steering. Unexpected or unwanted developments are detected easily, and the user can focus the exploration on them. The solution was evaluated with two case studies focusing on placing and testing flood defense measures. Both were evaluated by a consortium of flood simulation and defense experts, who found the system to be both intuitive and relevant. PMID:23559514

  4. Soil inoculation steers restoration of terrestrial ecosystems.

    Science.gov (United States)

    Wubs, E R Jasper; van der Putten, Wim H; Bosch, Machiel; Bezemer, T Martijn

    2016-01-01

    Many natural ecosystems have been degraded because of human activities(1,2) and need to be restored so that biodiversity is protected. However, restoration can take decades and restoration activities are often unsuccessful(3) because of abiotic constraints (for example, eutrophication, acidification) and unfavourable biotic conditions (for example, competition or adverse soil community composition). A key question is what manageable factors prevent transition from degraded to restored ecosystems and what interventions are required for successful restoration(2,4). Experiments have shown that the soil community is an important driver of plant community development(5-8), suggesting that manipulation of the soil community is key to successful restoration of terrestrial ecosystems(3,9). Here we examine a large-scale, six-year-old field experiment on ex-arable land and show that application of soil inocula not only promotes ecosystem restoration, but that different origins of soil inocula can steer the plant community development towards different target communities, varying from grassland to heathland vegetation. The impact of soil inoculation on plant and soil community composition was most pronounced when the topsoil layer was removed, whereas effects were less strong, but still significant, when the soil inocula were introduced into intact topsoil. Therefore, soil inoculation is a powerful tool to both restore disturbed terrestrial ecosystems and steer plant community development. PMID:27398907

  5. ICESat-2 ATLAS Beam Steering Mechanism (BSM)

    Science.gov (United States)

    Hinkle, Matthew

    2015-01-01

    This work covers the design and test of a beam steering mechanism (BSM) used to accurately guide a laser on the Advanced Topographic Laser Altimeter System (ATLAS) down to Earth in order to measure elevation. It describes the main components in the BSM that allows it to perform and meet stringent requirements. Requirements of the BSM include two-axis steering of the transmitted laser beam, +-5000 uRad mechanical motion in each axis, and 1.5 uRad RMS pointing stability among many other requirements. The BSM uses four voice coil actuators in order to locate the mirror at the angle we need. There are four Differential Position Sensors that determine the position and angle of the mirror at all times. These sensors were verified through optical testing in both ambient and thermal conditions. Testing and extensive analyses were performed on the two-axis flexure throughout the program to check flexure thickness, positive margins, and infinite life. The mirror mount design has been modified to eliminate radial preload, while incorporating a titanium wave spring to provide an axial preload of 10.8N. The BSM underwent multiple tests in order to verify all components work as required under various conditions.

  6. Multiple branched adaptive steered molecular dynamics

    Science.gov (United States)

    Ozer, Gungor; Keyes, Thomas; Quirk, Stephen; Hernandez, Rigoberto

    2014-08-01

    Steered molecular dynamics, SMD, [S. Park and K. Schulten, J. Chem. Phys. 120, 5946 (2004)] combined with Jarzynski's equality has been used widely in generating free energy profiles for various biological problems, e.g., protein folding and ligand binding. However, the calculated averages are generally dominated by "rare events" from the ensemble of nonequilibrium trajectories. The recently proposed adaptive steered molecular dynamics, ASMD, introduced a new idea for selecting important events and eliminating the non-contributing trajectories, thus decreasing the overall computation needed. ASMD was shown to reduce the number of trajectories needed by a factor of 10 in a benchmarking study of decaalanine stretching. Here we propose a novel, highly efficient "multiple branching" (MB) version, MB-ASMD, which obtains a more complete enhanced sampling of the important trajectories, while still eliminating non-contributing segments. Compared to selecting a single configuration in ASMD, MB-ASMD offers to select multiple configurations at each segment along the reaction coordinate based on the distribution of work trajectories. We show that MB-ASMD has all benefits of ASMD such as faster convergence of the PMF even when pulling 1000 times faster than the reversible limit while greatly reducing the probability of getting trapped in a non-significant path. We also analyze the hydrogen bond breaking within the decaalanine peptide as we force the helix into a random coil and confirm ASMD results with less noise in the numerical averages.

  7. Experimental Study on Antivibration Control of Electrical Power Steering Systems

    Directory of Open Access Journals (Sweden)

    Zhaojian Wang

    2014-01-01

    Full Text Available We focus on the antivibration controller design problem for electrical power steering (EPS systems. The EPS system has significant advantages over the traditional hydraulic steering system. However, the improper motor controller design would lead to the steering wheel vibration. Therefore, it is necessary to investigate the antivibration control strategy. For the implementation study, we also present the motor driver design and the software design which is used to monitor the sensors and the control signal. Based on the investigation on the regular assistant algorithm, we summarize the difficulties and problems encountered by the regular algorithm. After that, in order to improve the performance of antivibration and the human-like steering feeling, we propose a new assistant strategy for the EPS. The experiment results of the bench test illustrate the effectiveness and flexibility of the proposed control strategy. Compared with the regular controller, the proposed antivibration control reduces the vibration of the steering wheel a lot.

  8. Sidelobe Suppression with Null Steering by Independent Weight Control

    Directory of Open Access Journals (Sweden)

    Zafar-Ullah Khan

    2015-01-01

    Full Text Available A uniform linear array of n antenna elements can steer up to n-1 nulls. In situations where less than n-1 nulls are required to be steered, the existing algorithms have no criterion to utilize the remaining weights for sidelobe suppression. This work combines sidelobe suppression capability with null steering by independent weight control. For this purpose, the array factor is transformed as the product of two polynomials. One of the polynomials is used for null steering by independent weight control, while the second one is for sidelobe suppression whose coefficients or weights are determined by using convex optimization. Finally, a new structure is proposed to incorporate the product of two polynomials such that sidelobe suppression weights are decoupled from those of null steering weights. Simulation results validate the effectiveness of the proposed scheme.

  9. Conclusive quantum steering with superconducting transition edge sensors

    CERN Document Server

    Smith, Devin H; de Almeida, Marcelo; Branciard, Cyril; Fedrizzi, Alessandro; Weinhold, Till J; Lita, Adriana; Calkins, Brice; Gerrits, Thomas; Nam, Sae Woo; White, Andrew G

    2011-01-01

    Quantum steering allows two parties to verify shared entanglement even if one measurement device is untrusted. A conclusive demonstration of steering through the violation of a steering inequality is of considerable fundamental interest and opens up applications in quantum communication. To date all experimental tests with single photon states have relied on post-selection, allowing untrusted devices to cheat by hiding unfavorable events in losses. Here we close this "detection loophole" by combining a highly efficient source of entangled photon pairs with superconducting transition edge sensors. We achieve an unprecedented $\\sim$62% conditional detection efficiency of entangled photons and violate a steering inequality with the minimal number of measurement settings by 48 standard deviations. Our results provide a clear path to practical applications of steering and to a photonic loophole-free Bell test.

  10. The influence of different steering systems on a wheel slip

    Directory of Open Access Journals (Sweden)

    D. Stajnko

    2012-12-01

    Full Text Available Purpose: Modern and advanced mountain tractor allows four different modes of steering wheels: front wheels, back wheels, four wheels and crab steering. The current paper presents the impact of different ways of steering to control the slip in the work transverse on the steep hill slope (39.08%. Design/methodology/approach: For each mode of steering eight measurements were made; four measurements at a forecasted speed of 0.69 m/s and four measurements at a speed of 1.39 m/s. During the two of four measurements the travelling direction was from the left to the right, and vice versa.Findings: The measured slip depended significantly on the steering system, while the driving direction did not cause any differences in the slip.Research limitations/implications: The experiment results presented herein can be applied only with the similar mountain tractors, which allows four different modes of steering wheels. Additional limitation represents the working polygon and the growing conditions of grass.Practical implications: The crab - steering resulted in the smallest slip (5.96% at the average driving speed of 1.08 m/s. When steering with all four wheels, the slip at the average speed of 1.03 m/s increased to 7.27%. The biggest slip was measured when steering with only front wheels was applied. In this case the slip was 8.07% at the average speed of 1.01 m/s.Originality/value: The findings from our experiments indicated that it is very useful to have all wheels steering tractor when working on step slope, because it is grass friendly, offers bigger agility of tractor and improve the safety of the operator.

  11. Steering of H- ion beamlet by aperture displacement

    International Nuclear Information System (INIS)

    Focussing of multibeamlets produced from a large accelerator grid is a key issue of ion beam application to the neutral beam injector (NBI) of fusion devices. Another issue is highlighted in a case of negative ion based NBI to compensate beamlet deflection inside the extractor, where magnetic field is applied for suppression of electron extraction. Steering of H- beamlet was carried out by displacing apertures in an electrostatic extractor/accelerator composed of four grids, where the beam energy was in the range of ∼50 keV. Out of a few combination of grid displacement, displacement of ESG (3rd grid) and/or GRG (4th grid) was found to be successful: 1) The beamlet steering angle of 50 mrad was obtained by displacing the apertures of 9 mm dia. up to 3 mm. It was confirmed that the steering angle was proportional fairly well to the displacement. The characteristic of the steering, i.e., the steering angle as a function of displacement, agrees well with the analysis based on the linear optics theory. 2) Neither significant divergence growth nor the beam interception were observed in the steered beams over a wide range of operation. The H- beams, of which divergent angle was 5 mrad, was obtained even under the beamlet steering. Thus the steering by displacement is suitable for the focusing of negative ion beam generated from multi-aperture grids. 3) It was found that the steering angle was independent of the magnetic field direction in the present extractor structure. This is an advantage of the steering technique for compensation of the beam deflection inside the extractor by magnetic field. (author)

  12. Thiol redox homeostasis in neurodegenerative disease

    Directory of Open Access Journals (Sweden)

    Gethin J. McBean

    2015-08-01

    Full Text Available This review provides an overview of the biochemistry of thiol redox couples and the significance of thiol redox homeostasis in neurodegenerative disease. The discussion is centred on cysteine/cystine redox balance, the significance of the xc− cystine–glutamate exchanger and the association between protein thiol redox balance and neurodegeneration, with particular reference to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and glaucoma. The role of thiol disulphide oxidoreductases in providing neuroprotection is also discussed.

  13. ATLAS Beam Steering Mechanism (BSM) Lessons Learned

    Science.gov (United States)

    Blumenstock, Kenneth A.; Cramer, Alexander K.; Gosten, Alan B.; Hakun, Claef F.; Haney, Paul G.; Hinkle, Matthew R.; Lee, Kenneth Y.; Lugo, Carlos F.; Matuszeski, Adam J.; Morell, Armando; Armani, Nerses V.; Bonafede, Joseph; Jackson, Molly I.; Steigner, Peter J.; Stromsdorfer, Juan J.

    2016-01-01

    This paper describes the design, testing, and lessons learned during the development of the Advanced Topographic Laser Altimeter System (ATLAS) Beam Steering Mechanism (BSM). The BSM is a 2 degree-of-freedom tip-tilt mechanism for the purpose of pointing a flat mirror to tightly control the co-alignment of the transmitted laser and the receiver telescope of the ATLAS instrument. The high resolution needs of the mission resulted in sub-arcsecond pointing and knowledge requirements, which have been met. Development of the methodology to verify performance required significant effort. The BSM will fly as part of the Ice, Cloud, and Elevation Satellite II Mission (ICESat II), which is scheduled to be launched in 2017. The ICESat II primary mission is to map the Earth's surface topography for the determination of seasonal changes of ice sheet thickness and vegetation canopy thickness to establish long-term trends.

  14. ATLAS Beam Steering Mechanism Lessons Learned

    Science.gov (United States)

    Blumenstock, Kenneth A.; Cramer, Alexander K.; Gostin, Alan B.; Hakun, Claef F.; Haney, Paul G.; Hinkle, Matthew R.; Lee, Kenneth Y.; Lugo, Carlos F.; Matuszeski, Adam J.; Morrell, Armando; Armani, Nerses V.; Bonafede, Joseph; Jackson, Molly I.; Steigner, Peter J.; Stromsdorfer, Juan J.

    2016-01-01

    This paper describes the design, testing, and lessons learned during the development of the Advanced Topographic Laser Altimeter System (ATLAS) Beam Steering Mechanism (BSM). The BSM is a 2 degree-of-freedom tip-tilt mechanism for the purpose of pointing a flat mirror to tightly control the co-alignment of the transmitted laser and the receiver telescope of the ATLAS instrument. The high resolution needs of the mission resulted in sub-arcsecond pointing and knowledge requirements, which have been met. Development of the methodology to verify performance required significant effort. The BSM will fly as part of the Ice, Cloud, and Elevation Satellite II Mission (ICESat II), which is scheduled to be launched in 2017. The ICESat II primary mission is to map the earth's surface topography for the determination of seasonal changes of ice sheet thickness and vegetation canopy thickness to establish long-term trends.

  15. Beam Steering Mechanism (BSM) Lessons Learned

    Science.gov (United States)

    Blumenstock, Kenneth A.; Cramer, Alexander K.; Gostin, Alan B.; Hakun, Claef F.; Haney, Paul G.; Hinkle, Matthew R.; Lee, Kenneth Y.; Lugo, Carlos F.; Matuszeski, Adam J.; Morell, Armando; Armani, Nerses V.; Bonafede, Joseph; Jackson, Molly I.; Steigner, Peter J.; Stromsdorfer, Juan J.

    2016-01-01

    This paper describes the design, testing, and lessons learned during the development of the Advanced Topographic Laser Altimeter System (ATLAS) Beam Steering Mechanism (BSM). The BSM is a 2 degree-of-freedom tip-tilt mechanism for the purpose of pointing a flat mirror to tightly control the co-alignment of the transmitted laser and the receiver telescope of the ATLAS instrument. High resolution needs of the mission resulted in sub-arcsecond pointing and knowledge requirements, which have been met. Development of methodology to verify performance was a significant effortadvancement. The BSM will fly as part of the Ice, Cloud, and Elevation Satellite 2 Mission (ICESat 2), which is scheduled to be launched in 2017. The ICESat 2 primary mission is to map the earths surface topography for the determination of seasonal changes of ice sheet thickness as well as vegetation canopy thickness.

  16. Ka-Band Beam Steering Reflectarray Study

    Science.gov (United States)

    McSpadden, James O.; Fan, Lu; Chang, Kai; Huang, John

    1999-01-01

    A one-meter diameter, 32 GHz active microstrip reflectarray capable of electronic beam steering has been studied. The 15_500 element array consists of rnicrostrip patch antennas, microstrip phase shifters, and dc bias lines. Specifically, the study focused on the solid-state devices and dc bias layouts for scanning the beam linearly 45 from boresight using 2-bit phase shifters. Three configurations are recommended for the reflectarray with integrated 2-bit phase shifters where the total substrate and cladding mass varies from 8 kg to 14 kg. Additionally, dc power requirements for p-i-n diodes in 1-bit, 2-bit and 3-bit phase shifting circuits are approximately 19 W, 19 W, and 39 W, respectively. The dc power requirement for phase shifters using passive MESFETs is much less than 1 W.

  17. Beam steering in the SLC linac

    International Nuclear Information System (INIS)

    In order to control emittance growth due to transverse wakefields it will be necessary to transport electrons and positrons through the Stanford Linear Collider (SLC) linac to within a hundred μm of the centers of the linac irises. Beam centering will be accomplished using computer routines to read stripline beam position monitors and in turn correct the orbits with dipole magnets. Several different steering algorithms have been investigated using electrons in the first third of the SLC linac lattice. The most promising scheme is a cascade of modified ''three-bumps'' in conjunction with long spanning harmonic corrections. General features of the orbit correcting software are discussed along with the mathematical recipes for correction. Experimental results and a discussion of future plans are presented

  18. Phase shifter for antenna beam steering

    Science.gov (United States)

    Jindal, Ravi; Razban, Tchanguiz

    2016-03-01

    Wide band Array Antenna operates in Ku-band (10.7-12.7 GHz) frequency composed of N×N radiating elements. This antenna aims at the reception of television satellite signals. The goal of this research is to provide better possibility of electronic beam control instead of manual or mechanical control, and design compact and low cost phase shifters to be inserted in the feeding network of this antenna. The electronic control of the phase shifter will allow the control of beam steering. The emphasis of this project will be done at the beginning on the design of a good phase shifter in Ku band. The aim of this research is to define, simulate, release and measure a continuous phase shifter. Better reflection loss, low transmission loss, low Cost of array antennas, large range of phase-shifter, phase flatness and bandwidth will be achieved by providing better gain.

  19. The need for speed: global optic flow speed influences steering.

    Science.gov (United States)

    Kountouriotis, Georgios K; Mole, Callum D; Merat, Natasha; Wilkie, Richard M

    2016-05-01

    How do animals follow demarcated paths? Different species are sensitive to optic flow and one control solution is to maintain the balance of flow symmetry across visual fields; however, it is unclear whether animals are sensitive to changes in asymmetries when steering along curved paths. Flow asymmetries can alter the global properties of flow (i.e. flow speed) which may also influence steering control. We tested humans steering curved paths in a virtual environment. The scene was manipulated so that the ground plane to either side of the demarcated path produced larger or smaller asymmetries in optic flow. Independent of asymmetries and the locomotor speed, the scene properties were altered to produce either faster or slower globally averaged flow speeds. Results showed that rather than being influenced by changes in flow asymmetry, steering responded to global flow speed. We conclude that the human brain performs global averaging of flow speed from across the scene and uses this signal as an input for steering control. This finding is surprising since the demarcated path provided sufficient information to steer, whereas global flow speed (by itself) did not. To explain these findings, existing models of steering must be modified to include a new perceptual variable: namely global optic flow speed. PMID:27293789

  20. S-glutathionylated serine proteinase inhibitors as plasma biomarkers in assessing response to redox-modulating drugs.

    Science.gov (United States)

    Grek, Christina L; Townsend, Danyelle M; Uys, Joachim D; Manevich, Yefim; Coker, Woodrow J; Pazoles, Christopher J; Tew, Kenneth D

    2012-05-01

    Many cancer drugs impact cancer cell redox regulatory mechanisms and disrupt redox homeostasis. Pharmacodynamic biomarkers that measure therapeutic efficacy or toxicity could improve patient management. Using immunoblot analyses and mass spectrometry, we identified that serpins A1 and A3 were S-glutathionylated in a dose- and time-dependent manner following treatment of mice with drugs that alter reactive oxygen or nitrogen species. Tandem mass spectrometry analyses identified Cys(256) of serpin A1 and Cys(263) of serpin A3 as the S-glutathionylated residues. In human plasma from cancer patients, there were higher levels of unmodified serpin A1 and A3, but following treatments with redox active drugs, relative S-glutathionylation of these serpins was higher in plasma from normal individuals. There is potential for S-glutathionylated serpins A1 and A3 to act as pharmacodynamic biomarkers for evaluation of patient response to drugs that target redox pathways. PMID:22406622

  1. Molecular analysis of Ku redox regulation

    Directory of Open Access Journals (Sweden)

    Shatilla Andrea

    2009-08-01

    Full Text Available Abstract Background DNA double-strand breaks (DSBs can occur in response to ionizing radiation (IR, radiomimetic agents and from endogenous DNA-damaging reactive oxygen metabolites. Unrepaired or improperly repaired DSBs are potentially the most lethal form of DNA damage and can result in chromosomal translocations and contribute to the development of cancer. The principal mechanism for the repair of DSBs in humans is non-homologous end-joining (NHEJ. Ku is a key member of the NHEJ pathway and plays an important role in the recognition step when it binds to free DNA termini. Ku then stimulates the assembly and activation of other NHEJ components. DNA binding of Ku is regulated by redox conditions and evidence from our laboratory has demonstrated that Ku undergoes structural changes when oxidized that results in a reduction in DNA binding activity. The C-terminal domain and cysteine 493 of Ku80 were investigated for their contribution to redox regulation of Ku. Results We effectively removed the C-terminal domain of Ku80 generating a truncation mutant and co-expressed this variant with wild type Ku70 in an insect cell system to create a Ku70/80ΔC heterodimer. We also generated two single amino acid variants of Cys493, replacing this amino acid with either an alanine (C493A or a serine (C493S, and over-expressed the variant proteins in SF9 insect cells in complex with wild type Ku70. Neither the truncation nor the amino acid substitutions alters protein expression or stability as determined by SDS-PAGE and Western blot analysis. We show that the C493 mutations do not alter the ability of Ku to bind duplex DNA in vitro under reduced conditions while truncation of the Ku80 C-terminus slightly reduced DNA binding affinity. Diamide oxidation of cysteines was shown to inhibit DNA binding similarly for both the wild-type and all variant proteins. Interestingly, differential DNA binding activity following re-reduction was observed for the Ku70/80

  2. Lung extracellular matrix and redox regulation.

    Science.gov (United States)

    Watson, Walter H; Ritzenthaler, Jeffrey D; Roman, Jesse

    2016-08-01

    Pulmonary fibrosis affects millions worldwide and, even though there has been a significant investment in understanding the processes involved in wound healing and maladaptive repair, a complete understanding of the mechanisms responsible for lung fibrogenesis eludes us, and interventions capable of reversing or halting disease progression are not available. Pulmonary fibrosis is characterized by the excessive expression and uncontrolled deposition of extracellular matrix (ECM) proteins resulting in erosion of the tissue structure. Initially considered an 'end-stage' process elicited after injury, these events are now considered pathogenic and are believed to contribute to the course of the disease. By interacting with integrins capable of signal transduction and by influencing tissue mechanics, ECM proteins modulate processes ranging from cell adhesion and migration to differentiation and growth factor expression. In doing so, ECM proteins help orchestrate complex developmental processes and maintain tissue homeostasis. However, poorly controlled deposition of ECM proteins promotes inflammation, fibroproliferation, and aberrant differentiation of cells, and has been implicated in the pathogenesis of pulmonary fibrosis, atherosclerosis and cancer. Considering their vital functions, ECM proteins are the target of investigation, and oxidation-reduction (redox) reactions have emerged as important regulators of the ECM. Oxidative stress invariably accompanies lung disease and promotes ECM expression directly or through the overproduction of pro-fibrotic growth factors, while affecting integrin binding and activation. In vitro and in vivo investigations point to redox reactions as targets for intervention in pulmonary fibrosis and related disorders, but studies in humans have been disappointing probably due to the narrow impact of the interventions tested, and our poor understanding of the factors that regulate these complex reactions. This review is not meant to

  3. Lung extracellular matrix and redox regulation

    Directory of Open Access Journals (Sweden)

    Walter H. Watson

    2016-08-01

    Full Text Available Pulmonary fibrosis affects millions worldwide and, even though there has been a significant investment in understanding the processes involved in wound healing and maladaptive repair, a complete understanding of the mechanisms responsible for lung fibrogenesis eludes us, and interventions capable of reversing or halting disease progression are not available. Pulmonary fibrosis is characterized by the excessive expression and uncontrolled deposition of extracellular matrix (ECM proteins resulting in erosion of the tissue structure. Initially considered an ‘end-stage’ process elicited after injury, these events are now considered pathogenic and are believed to contribute to the course of the disease. By interacting with integrins capable of signal transduction and by influencing tissue mechanics, ECM proteins modulate processes ranging from cell adhesion and migration to differentiation and growth factor expression. In doing so, ECM proteins help orchestrate complex developmental processes and maintain tissue homeostasis. However, poorly controlled deposition of ECM proteins promotes inflammation, fibroproliferation, and aberrant differentiation of cells, and has been implicated in the pathogenesis of pulmonary fibrosis, atherosclerosis and cancer. Considering their vital functions, ECM proteins are the target of investigation, and oxidation–reduction (redox reactions have emerged as important regulators of the ECM. Oxidative stress invariably accompanies lung disease and promotes ECM expression directly or through the overproduction of pro-fibrotic growth factors, while affecting integrin binding and activation. In vitro and in vivo investigations point to redox reactions as targets for intervention in pulmonary fibrosis and related disorders, but studies in humans have been disappointing probably due to the narrow impact of the interventions tested, and our poor understanding of the factors that regulate these complex reactions. This

  4. Steering Control of Wheeled Armored Vehicle with Brushless DC Motor

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Considering the steering characters of one type of wheeled armored vehicle, a brushless direct current (DC) motor is adapted as the actuator for steering control. After investigating the known algorithms, one kind of algorithm, which combines the fuzzy logic control with the self-adapting PID control and the startup and pre-brake control, is put forward. Then a test-bed is constructed, and an experiment is conducted. The result of experiment confirms the validity of this algorithm in steering control of wheeled armored vehicle with brushless DC motor.

  5. Simultaneous demultiplexing and steering of multiple orbital angular momentum modes

    Science.gov (United States)

    Li, Shuhui; Wang, Jian

    2015-01-01

    We present a simple scheme to perform simultaneous demultiplexing and steering of multiple orbital angular momentum (OAM) modes using a single complex phase mask. By designing the phase mask, the propagation directions of demultiplexed beams can be arbitrarily steered. System experiments using orthogonal frequency-division multiplexing 32-ary quadrature amplitude modulation (OFDM-32QAM) signals over two OAM modes are carried out by using a two-mode complex phase mask. Moreover, demultiplexing of sixteen OAM modes and arbitrary demultiplexed beam steering are also demonstrated in the experiment. PMID:26503167

  6. Simultaneous demultiplexing and steering of multiple orbital angular momentum modes.

    Science.gov (United States)

    Li, Shuhui; Wang, Jian

    2015-01-01

    We present a simple scheme to perform simultaneous demultiplexing and steering of multiple orbital angular momentum (OAM) modes using a single complex phase mask. By designing the phase mask, the propagation directions of demultiplexed beams can be arbitrarily steered. System experiments using orthogonal frequency-division multiplexing 32-ary quadrature amplitude modulation (OFDM-32QAM) signals over two OAM modes are carried out by using a two-mode complex phase mask. Moreover, demultiplexing of sixteen OAM modes and arbitrary demultiplexed beam steering are also demonstrated in the experiment. PMID:26503167

  7. Laser Beam Steering/shaping for Free Space Optical Communication

    Science.gov (United States)

    Wang, Xinghua; Wang, Bin; Bos, Philip J.; Anderson, James E.; Pouch, John; Miranda, Felix; McManamon, Paul F.

    2004-01-01

    The 2-D Optical Phased Array (OPA) antenna based on a Liquid Crystal On Silicon (LCoS) device can be considered for use in free space optical communication as an active beam controlling device. Several examples of the functionality of the device include: beam steering in the horizontal and elevation direction; high resolution wavefront compensation in a large telescope; and beam shaping with the computer generated kinoform. Various issues related to the diffraction efficiency, steering range, steering accuracy as well as the magnitude of wavefront compensation are discussed.

  8. Simultaneous demultiplexing and steering of multiple orbital angular momentum modes

    Science.gov (United States)

    Li, Shuhui; Wang, Jian

    2015-10-01

    We present a simple scheme to perform simultaneous demultiplexing and steering of multiple orbital angular momentum (OAM) modes using a single complex phase mask. By designing the phase mask, the propagation directions of demultiplexed beams can be arbitrarily steered. System experiments using orthogonal frequency-division multiplexing 32-ary quadrature amplitude modulation (OFDM-32QAM) signals over two OAM modes are carried out by using a two-mode complex phase mask. Moreover, demultiplexing of sixteen OAM modes and arbitrary demultiplexed beam steering are also demonstrated in the experiment.

  9. 46 CFR 196.37-33 - Instructions for changing steering gear.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Instructions for changing steering gear. 196.37-33... steering gear. (a) Instructions in at least 1/2 inch letters and figures shall be posted in the steering engineroom, relating in order, the different steps to be taken in changing to the emergency steering...

  10. Effect of feeding system on performance and carcass characteristics of yearling steers, steer calves and heifer calves.

    Science.gov (United States)

    Danner, M L; Fox, D G; Black, J R

    1980-03-01

    Three types of cattle (Angus x Hereford yearling steers, Charolais x British breed steer calves and Hereford heifer calves) were evaluated for their response to different feeding systems utilizing high moisture corn, corn silage and soybean meal as major feed ingredients. Feeding ing systems for steers included: A = 85% concentrate; B = 40% concentrate; C = two phase, with switch from all corn silage to 85% concentrate in the middle of the feeding period; D = same as C except switch occurred late in the feeding period; E = all corn silage continuously. Heifer diets consisted of the following ratios of corn silage to concentrate: low energy = 89:11; medium energy = 67:33; and high energy = 100 fed at a moderate (10.9% for low energy and medium energy, and 11.7% for high energy) and high (13.8%) crude protein level. Treatments within each experiment were terminated at approximately the same final weight. Increasing percentage corn added to the total diet increased ADG in most comparisons. Adjusted to a constant carcass weight, increasing dietary energy increased fat thickness and reduced percentage retail product with no effect on quality grade in yearling steers and heifer calves. In Charolais cross-steer calves, increasing energy level increased quality grade with no effect on yield grade or percentage retail product. Energetic efficiency slightly favored system C in yearling steers while steer calves maximized efficiency on A. Hereford heifers were the most energetically efficient on medium energy diets. PMID:7364676

  11. Cascade redox flow battery systems

    Science.gov (United States)

    Horne, Craig R.; Kinoshita, Kim; Hickey, Darren B.; Sha, Jay E.; Bose, Deepak

    2014-07-22

    A reduction/oxidation ("redox") flow battery system includes a series of electrochemical cells arranged in a cascade, whereby liquid electrolyte reacts in a first electrochemical cell (or group of cells) before being directed into a second cell (or group of cells) where it reacts before being directed to subsequent cells. The cascade includes 2 to n stages, each stage having one or more electrochemical cells. During a charge reaction, electrolyte entering a first stage will have a lower state-of-charge than electrolyte entering the nth stage. In some embodiments, cell components and/or characteristics may be configured based on a state-of-charge of electrolytes expected at each cascade stage. Such engineered cascades provide redox flow battery systems with higher energy efficiency over a broader range of current density than prior art arrangements.

  12. Redox-dependent regulation of epidermal growth factor receptor signaling.

    Science.gov (United States)

    Heppner, David E; van der Vliet, Albert

    2016-08-01

    Tyrosine phosphorylation-dependent cell signaling represents a unique feature of multicellular organisms, and is important in regulation of cell differentiation and specialized cell functions. Multicellular organisms also contain a diverse family of NADPH oxidases (NOXs) that have been closely linked with tyrosine kinase-based cell signaling and regulate tyrosine phosphorylation via reversible oxidation of cysteine residues that are highly conserved within many proteins involved in this signaling pathway. An example of redox-regulated tyrosine kinase signaling involves the epidermal growth factor receptor (EGFR), a widely studied receptor system with diverse functions in normal cell biology as well as pathologies associated with oxidative stress such as cancer. The purpose of this Graphical Redox Review is to highlight recently emerged concepts with respect to NOX-dependent regulation of this important signaling pathway. PMID:26722841

  13. Lacasse with high redox potential

    OpenAIRE

    Maté, Diana M.; Valdivieso, Malena; Fernández, Layla; Alcalde Galeote, Miguel

    2010-01-01

    [EN] The invention relates to the directed evolution of a lacasse with high redox potential, functionally expressed in S. cerevisiae, which has a high production rate, high activity and high heat stability. The invention relates to the amino acid sequence of the lacas se and to the nucleotide sequence that codes for said lacas se. The lacasse of the invention is suitable for use in different sectors: nano-biotechnology, the paper industry, bioremediation, the textile industry, the fo...

  14. Redox Pioneer: Professor Helmut Sies

    OpenAIRE

    Jones, Dean P.; Radi, Rafael

    2014-01-01

    Dr. Helmut Sies (MD, 1967) is recognized as a Redox Pioneer, because he authored five articles on oxidative stress, lycopene, and glutathione, each of which has been cited more than 1000 times, and coauthored an article on hydroperoxide metabolism in mammalian systems cited more than 5000 times (Google Scholar). He obtained preclinical education at the University of Tübingen and the University of Munich, clinical training at Munich (MD, 1967) and Paris, and completed Habilitation at Munich (P...

  15. Evaluation of Potential Usage of Incremental-Type Rotary Encoder Application for Angle Sensing in Steering System

    OpenAIRE

    Sunarto Kaleg; Aam Muharam; M. Redho Kurnia; Abdul Hapid

    2014-01-01

    The main target of a steering system is that the driver can change vehicle trajectory in accordance with the desired direction.  Power steering has become a standard feature in automobile.  It provides assisting power when the driver turns the steering wheel. The well-known power steering types include; Hydraulic Power Steering (HPS), Electro - Hydraulic Power Steering (EHPS), and Electric Power Steering (EPS). EHPS or EPS uses an Electronic Control Unit (ECU) which is specific for each vehic...

  16. The Impact of Analog and Bang-Bang Steering Gear Control on Ship's Fuel Economy

    DEFF Research Database (Denmark)

    Nørtoft Thomsen, J. C.; Blanke, Mogens; Reid, R. E.;

    1982-01-01

    The latest years have shown considerable efforts towards improving steering generated propulsion losses of ships by the introduction of various sophisticated control algorithms in the autopilots. However, little previous attention has been given to the steering gear control loop, although it is...... found to be at least equally important regarding steering performance and fuel economy. The paper presents a comprehensive survey of steering gear principles commonly used, including relevant details of three analog steering gear servo principles, which have outperformed conventional designs. Control...

  17. Performance on steering power ratio of tracked vehicles influenced by soil parameters

    OpenAIRE

    Chi Yuan; Zhang Rongrong; Wang Hongtao; Shi Dandan

    2015-01-01

    In order to study tracked vehicle adopting different steering mechanism, we use steering power ratio to evaluate its performance. The influencing factors of steering power ratio have been theoretically studied. And we designed the experimental prototype to test. We find that steering power ratio is related to vehicle parameters, resistance coefficient, turning radius, skid ratio, slip ratio and steering coefficient not only, but also it is related to soil parameters (including soil cohesion, ...

  18. Genuine High-Order Einstein-Podolsky-Rosen Steering

    Science.gov (United States)

    Li, Che-Ming; Chen, Kai; Chen, Yueh-Nan; Zhang, Qiang; Chen, Yu-Ao; Pan, Jian-Wei

    2015-07-01

    Einstein-Podolsky-Rosen (EPR) steering demonstrates that two parties share entanglement even if the measurement devices of one party are untrusted. Here, going beyond this bipartite concept, we develop a novel formalism to explore a large class of EPR steering from generic multipartite quantum systems of arbitrarily high dimensionality and degrees of freedom, such as graph states and hyperentangled systems. All of these quantum characteristics of genuine high-order EPR steering can be efficiently certified with few measurement settings in experiments. We faithfully demonstrate for the first time such generality by experimentally showing genuine four-partite EPR steering and applications to universal one-way quantum computing. Our formalism provides a new insight into the intermediate type of genuine multipartite Bell nonlocality and potential applications to quantum information tasks and experiments in the presence of untrusted measurement devices.

  19. Electrical power assisted steering for EVs and HEVs

    Institute of Scientific and Technical Information of China (English)

    Ma Haibo; Yang Ying

    2011-01-01

    Electrical power assisted steering (EPAS) is one of the key components, especially for electrical vehicle. It has attracted much attention for their advantages with respect to improved fuel economy and has been widely adopted as automotive power-steering equipment in recent years. EPS (electrical power steering) controllers contain MCU (microprocessor control unit) to implement the complex control algorithms. EPS control strategy development is the core technology of the whole system. To achieve the better performance of driving, both mechanical structures and electrical structures are totally designed as a whole. Model-based development is recommended to software design. There are several trends about EPS' future, such as high power EPS development, high voltage EPS development and steering-bywire technology.

  20. Steering of Solar Sails Using Optical Lift Force Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This study seeks to look beyond the use of radiation pressure for thrust, and to explore a means of solar navigation whereby a solar craft would be steered by use...

  1. A null-steering viewpoint of interferometric SAR

    Energy Technology Data Exchange (ETDEWEB)

    BICKEL,DOUGLAS L.

    2000-05-02

    Interferometric synthetic aperture radar (IFSAR) extends the two-dimensional imaging capability of traditional synthetic aperture radar to three-dimensions by using an aperture in the elevation plane to estimate the 3-D structure of the target. The operation of this additional aperture can be viewed from a null-steering point of view, rather than the traditional phase determination point of view. Knowing that IFSAR can be viewed from the null-steering perspective allows one to take advantage of the mathematical foundation developed for null-steering arrays. In addition, in some problems of interest in IFSAR the null-steering perspective provides better intuition and suggests alternative solutions. One example is the problem of estimating building height where layover is present.

  2. Simulation Training in Early Emergency Response (STEER).

    Science.gov (United States)

    Generoso, Jose Roberto; Latoures, Renee Elizabeth; Acar, Yahya; Miller, Dean Scott; Ciano, Mark; Sandrei, Renan; Vieira, Marlon; Luong, Sean; Hirsch, Jan; Fidler, Richard Lee

    2016-06-01

    HOW TO OBTAIN CONTACT HOURS BY READING THIS ISSUE Instructions: 1.3 contact hours will be awarded by Villanova University College of Nursing upon successful completion of this activity. A contact hour is a unit of measurement that denotes 60 minutes of an organized learning activity. This is a learner-based activity. Villanova University College of Nursing does not require submission of your answers to the quiz. A contact hour certificate will be awarded after you register, pay the registration fee, and complete the evaluation form online at http://goo.gl/gMfXaf. In order to obtain contact hours you must: 1. Read the article, "Simulation Training in Early Emergency Response (STEER)," found on pages 255-263, carefully noting any tables and other illustrative materials that are included to enhance your knowledge and understanding of the content. Be sure to keep track of the amount of time (number of minutes) you spend reading the article and completing the quiz. 2. Read and answer each question on the quiz. After completing all of the questions, compare your answers to those provided within this issue. If you have incorrect answers, return to the article for further study. 3. Go to the Villanova website to register for contact hour credit. You will be asked to provide your name, contact information, and a VISA, MasterCard, or Discover card number for payment of the $20.00 fee. Once you complete the online evaluation, a certificate will be automatically generated. This activity is valid for continuing education credit until May 31, 2019. CONTACT HOURS This activity is co-provided by Villanova University College of Nursing and SLACK Incorporated. Villanova University College of Nursing is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation. OBJECTIVES Define the purpose of the Simulation Training in Early Emergency Response (STEER) study. Review the outcome of the STEER study. DISCLOSURE

  3. Two Dimensional Array Imaging with Beam Steered Data

    OpenAIRE

    Patole, Sujeet; Torlak, Murat

    2013-01-01

    This paper discusses different approaches used for millimeter wave imaging of two-dimensional objects. Imaging of a two dimensional object requires reflected wave data to be collected across two distinct dimensions. In this paper, we propose a reconstruction method that uses narrowband waveforms along with two dimensional beam steering. The beam is steered in azimuthal and elevation direction, which forms the two distinct dimensions required for the reconstruction. The Reconstruction techniqu...

  4. Optical beam steering based on electromagnetically induced transparency

    International Nuclear Information System (INIS)

    We propose a scheme that provides all-optically-controlled steering of light beam. The system is based on steep dispersion of a coherently driven medium. Using the eikonal equation, we study the steering angle, the spread of the optical beam, and the limits set by residual absorption of the medium under conditions of electromagnetically induced transparency. Implementation of another scheme for ultrashort pulses is also discussed

  5. A micromechanical beam-steering device for terahertz systems

    OpenAIRE

    Drysdale, T.D.; Cumming, D.R.S.

    2004-01-01

    Beam-steering techniques are required to fully exploit terahertz imaging systems. We propose and model a device employing artificial dielectric techniques to provide a variable phase-control medium. The device consists of two interlocking artificial dielectric surfaces that are initially aligned parallel to each other. By mechanically introducing a relative tilt between the plates, a transmitted wave is subjected to a graded phase delay and thus the beam is steered away from the normal. Conti...

  6. Laser beam steering for GRACE Follow-On intersatellite interferometry

    OpenAIRE

    Schütze, D; Stede, G.; Müller, V.; Gerberding, O.; Bandikova, T.; Sheard, B.; Heinzel, G.; Danzmann, K

    2014-01-01

    The GRACE Follow-On satellites will use, for the first time, a Laser Ranging Interferometer to measure intersatellite distance changes from which fluctuations in Earth’s geoid can be inferred. We have investigated the beam steering method that is required to maintain the laser link between the satellites. Although developed for the specific needs of the GRACE Follow-On mission, the beam steering method could also be applied to other intersatellite laser ranging applications where major diffic...

  7. Beam-steering digital num array paramétrico

    OpenAIRE

    Cordeiro, Rui Fiel

    2012-01-01

    Several methods enable a steerable beam using an parametric loudspeaker. However, many of them are not able to use a high angular resolution with an e cient design. More, even the ability to change the beam steering in real time is neglected by several methods. In this document, we propose a new approach to the beam-steering problem using the intrinsic high frequency of a sigma-delta digital to analog converter conjugated with online con gurable digital delays obtained only ...

  8. Multiplexed broadband beam steering system utilizing high speed MEMS mirrors

    OpenAIRE

    Knoernschild, Caleb; Kim, Changsoon; Lu, Felix P.; Kim, Jungsang

    2009-01-01

    We present a beam steering system based on micro-electromechanical systems technology that features high speed steering of multiple laser beams over a broad wavelength range. By utilizing high speed micromirrors with a broadband metallic coating, our system has the flexibility to simultaneously incorporate a wide range of wavelengths and multiple beams. We demonstrate reconfiguration of two independent beams at different wavelengths (780 and 635 nm) across a common 5x5 array with 4 us settlin...

  9. Simultaneous demultiplexing and steering of multiple orbital angular momentum modes

    OpenAIRE

    Shuhui Li; Jian Wang

    2015-01-01

    We present a simple scheme to perform simultaneous demultiplexing and steering of multiple orbital angular momentum (OAM) modes using a single complex phase mask. By designing the phase mask, the propagation directions of demultiplexed beams can be arbitrarily steered. System experiments using orthogonal frequency-division multiplexing 32-ary quadrature amplitude modulation (OFDM-32QAM) signals over two OAM modes are carried out by using a two-mode complex phase mask. Moreover, demultiplexing...

  10. Steering and collimating ballistic electrons with amphoteric refraction

    International Nuclear Information System (INIS)

    We show that amphoteric refraction of ballistic electrons, i.e., positive or negative refraction depending on the incidence angle, occurs at an interface between an isotropic and an anisotropic medium and can be employed to steer and collimate electron beams. The steering angle is determined by the materials’ parameters, but the degree of collimation can be tuned in a significant range by changing the energy of ballistic electrons.

  11. Switched Reluctance Motor Drive for 42V Electric Power Steering

    OpenAIRE

    Andrada Gascón, Pedro; Blanqué Molina, Balduino; Martínez Piera, Eusebio; Perat Benavides, Josep Ignasi; Sánchez López, José Antonio; Torrent Burgués, Marcel

    2009-01-01

    In this paper, switched reluctance motors (SRM) are proposed as an alternative for electric power assisted steering (EPAS) applications. The new 42 V power voltage system is a very attractive design for a steering electric motor, both from a cost and size perspective. A four-phase 8/6 SRM drive is designed for a rack type EPAS which should provide a maximum force of 10 kN. Two-dimension finite element analysis is used to validate the design.

  12. Loophole-free Einstein Podolsky Rosen Experiment via Quantum Steering

    International Nuclear Information System (INIS)

    Full text: Experiments testing quantum mechanics have provided increasing evidence against local realistic theories. However, a conclusive test that simultaneously closes all major loopholes (the locality, freedom-of-choice, and detection loopholes) remains an open challenge. An important class of local realistic theories incorporates the assumption of quantum mechanic and can be tested with the concept of EPR-steering. The term steering was introduced by Schrödinger in 1935 for the fact that entanglement would seem to allow an experimenter to remotely steer or pilot the state of a distant system as used in the original Einstein–Podolsky–Rosen (EPR) paradox. EPR-Steering can be described in theory by the test of local hidden states. Here, we present the first loophole-free steering experiment. We use entangled photons shared between two distant laboratories and close all loopholes by a large separation, ultra-fast switching and quantum random number generation, and high, overall detection efficiency. Beside its foundational importance loop-hole-free steering is relevant for the secure distribution of quantum entanglement. (author)

  13. Effective design choices for skid-steering robotic vehicles

    Science.gov (United States)

    Sinha, Aakash K.; Rosenblum, Mark

    2004-12-01

    One of the major problems with any robotic vehicle is inefficient use of available power. This research explores in detail the locomotion, power dynamics and performance of a skid steered robotic vehicle and develops techniques to derive efficient design parameters of the vehicle in order to achieve optimal performance by minimizing the power losses/consumption. Three categories of design variables describe the vehicle and its dynamics; variables that describe the vehicle, variables that describe the surface on which it runs and variables that describe the vehicle"s motion. Two major constituent components of power losses/consumption of the vehicle are - losses in skid steer turning, and losses in rolling. Our focus is on skid steering, we present a detailed analysis of skid steering for different turning modes; elastic mode steering, half-slip steering, skid turns, low radius turns, and zero radius turns. Each of the power loss components is modeled from physics in terms of the design variables. The effect of design variables on the total power losses/consumption is then studied using simulated data for different types of surfaces i.e. hard surfaces and muddy surfaces. Finally, we make suggestions about efficient vehicle design choices in terms of the design variables.

  14. Redox characteristics of the eukaryotic cytosol

    DEFF Research Database (Denmark)

    López-Mirabal, H Reynaldo; Winther, Jakob R

    2007-01-01

    The eukaryotic cytoplasm has long been regarded as a cellular compartment in which the reduced state of protein cysteines is largely favored. Under normal conditions, the cytosolic low-molecular weight redox buffer, comprising primarily of glutathione, is highly reducing and reactive oxygen species...... (ROS) and glutathionylated proteins are maintained at very low levels. In the present review, recent progress in the understanding of the cytosolic thiol-disulfide redox metabolism and novel analytical approaches to studying cytosolic redox properties are discussed. We will focus on the yeast model...... restricting the cytosolic glutathione redox potential to a relatively narrow interval. Several mutations in genes involved in cellular redox regulation cause ROS accumulation but only moderate decreases in the cytosolic glutathione reducing power. The redox regulation in the cytosol depends not only on...

  15. Redox chemistry in the phosphorus biogeochemical cycle

    OpenAIRE

    Pasek, Matthew A.; Sampson, Jacqueline M.; Atlas, Zachary

    2014-01-01

    Phosphorus is an important nutrient for living organisms. Phosphorus is generally considered to bear a 5+ oxidation state, but several lower redox states have been reported, including the toxic gas phosphine. We show here that the lower redox states of phosphorus are common in Florida water samples, and that based on the global concentration of phosphine, we might expect to see 5−15% of all dissolved phosphorus in a lower redox state.

  16. Characterization of redox conditions in pollution plumes

    DEFF Research Database (Denmark)

    Christensen, Thomas Højlund; Bjerg, Poul Løgstrup; Banwart, Steven A.;

    2000-01-01

    Evalution of redox conditions in groundwater pollution plumes is often a prerequisite for understanding the behviour of the pollutants in the plume and for selecting remediation approaches. Measuring of redox conditions in pollution plumes is, however, a fairly recent issue and yet relative few c...... cases have been reported. No standardised or generally accepted approach exists. This paper evaluates the different methods for redox characterization based on the experiences from the reported applications....

  17. Membranes for Redox Flow Battery Applications

    OpenAIRE

    Maria Skyllas-Kazacos; Aishwarya Parasuraman; Tuti Mariana Lim; Suminto Winardi; Helen Prifti

    2012-01-01

    The need for large scale energy storage has become a priority to integrate renewable energy sources into the electricity grid. Redox flow batteries are considered the best option to store electricity from medium to large scale applications. However, the current high cost of redox flow batteries impedes the wide spread adoption of this technology. The membrane is a critical component of redox flow batteries as it determines the performance as well as the economic viability of the batteries. Th...

  18. Radii of Redox Components from Absolute Redox Potentials Compared with Covalent and Aqueous Ionic Radii

    Czech Academy of Sciences Publication Activity Database

    Heyrovská, Raji

    2010-01-01

    Roč. 22, č. 9 (2010), s. 903-907. ISSN 1040-0397 Institutional support: RVO:68081707 Keywords : Electrochemistry * Absolute redox potentials * Radii of redox components Subject RIV: BO - Biophysics Impact factor: 2.721, year: 2010

  19. Lacasa de alto potencial redox

    OpenAIRE

    Maté, Diana M.; Valdivieso, Malena; Fernández, Layla; Alcalde Galeote, Miguel

    2010-01-01

    La presente invención describe la evolución dirigida de una lacasa de alto potencial redox expresada funcionalmente en S. cerevisiae que presenta una alta tasa de producción, una elevada actividad y una gran termoestabilidad. La presente invención se refiere a la secuencia aminoacídica de dicha lacasa y a la secuencia nucleotídica que codifica para dicha lacasa. La lacasa de la invención presenta aplicaciones en diversos sectores: nano- biotecnología, industria papeler...

  20. Oxygen in human health from life to death – An approach to teaching redox biology and signaling to graduate and medical students

    Directory of Open Access Journals (Sweden)

    Margaret M. Briehl

    2015-08-01

    Full Text Available In the absence of oxygen human life is measured in minutes. In the presence of oxygen, normal metabolism generates reactive species (ROS that have the potential to cause cell injury contributing to human aging and disease. Between these extremes, organisms have developed means for sensing oxygen and ROS and regulating their cellular processes in response. Redox signaling contributes to the control of cell proliferation and death. Aberrant redox signaling underlies many human diseases. The attributes acquired by altered redox homeostasis in cancer cells illustrate this particularly well. This teaching review and the accompanying illustrations provide an introduction to redox biology and signaling aimed at instructors of graduate and medical students.

  1. Redox protective potential of fruits and vegetables:A review

    Institute of Scientific and Technical Information of China (English)

    Zainab Tahir; MuhammadArshad; Sunbal Khalil Chaudhari

    2015-01-01

    Although oxidation reactions are crucial for life, they can also be damaging to cells and tissues, causing variety of chronic ailments like, aging, cancer, autoimmune problems, cardiovascular and neurodegenerative disorders etc. Redox protective systems are present in body for general immunization against free radicals, which can be supported by antioxidants that we take in our daily diet. Natural antioxidants such as flavonoids, hydrolysable tannins, coumarins, xanthones, phenolics, terpenoids, ascorbic acid, carotenoids and proanthocyanins are found in various plant products, including fruits, leaves, seeds oils, and juices. This review gives a brief account of research reports on fruits and vegetables which provide free radical scavenging compounds to the body.

  2. Redox protective potential of fruits and vegetables: A review

    Directory of Open Access Journals (Sweden)

    Zainab Tahir

    2015-08-01

    Full Text Available Although oxidation reactions are crucial for life, they can also be damaging to cells and tissues, causing variety of chronic ailments like, aging, cancer, autoimmune problems, cardiovascular and neurodegenerative disorders etc. Redox protective systems are present in body for general immunization against free radicals, which can be supported by antioxidants that we take in our daily diet. Natural antioxidants such as flavonoids, hydrolysable tannins, coumarins, xanthones, phenolics, terpenoids, ascorbic acid, carotenoids and proanthocyanins are found in various plant products, including fruits, leaves, seeds oils, and juices. This review gives a brief account of research reports on fruits and vegetables which provide free radical scavenging compounds to the body.

  3. Backwards planning approach for rapid attitude maneuvers steering

    Science.gov (United States)

    Verbin, D.

    Remote sensing satellites are often built with payloads that do not include line of sight steering mechanisms. In cases, when frequent line of sight retargeting is required, there is a need for efficient actuators and control schemes that would support rapid attitude manoeuvring together with adequate pointing accuracy and stability between the manoeuvres. Within this frame, this research develops the Backwards Planning approach as one of the possible control methods for rapid manoeuvring. The method is based on state feedback and combines time efficient together with straight forward computation flow. Novel efficient methods to execute the Backwards Planning Control in the 3D attitude space are proposed here. The methods refer both for the first saturated control phase of the manoeuvre and for the last braking phase. The actuators used for the spacecraft control in this research are either Reaction Wheels (RWs) or Single Gimbal Control Moments Gyros (SGCMGs) or both of them together. The advantage of the SGCMG is in rapid rotational manoeuvring, but their application for high quality pointing requires very accurate gimbal mechanisms. On the other hand, RWs are usually more suitable for accurate pointing, but their torque to power performance is inferior in manoeuvring. It is shown that the coordination of SGCMGs and RWs together enables to draw more performance from the SGCMGs in terms of agility and meet the pointing requirements between manoeuvres where only the RWs are used. Novel SGCMG steering laws are suggested as well. While the steering laws determine the required angular rate for each gimbal, most steering laws are defined in the angular momentum domain and output the gimbals angular rates to produce a given required torque or angular momentum increment. This research however, practices a novel steering law in the gimbal angles domain. While both steering laws turn to be dynamically equivalent for small control signals, as in the steady state, it is shown

  4. Cancer

    Science.gov (United States)

    ... Blood tests (which look for chemicals such as tumor markers) Bone marrow biopsy (for lymphoma or leukemia) Chest ... the case with skin cancers , as well as cancers of the lung, breast, and colon. If the tumor has spread ...

  5. Cancer

    Science.gov (United States)

    Cancer begins in your cells, which are the building blocks of your body. Normally, your body forms ... be benign or malignant. Benign tumors aren't cancer while malignant ones are. Cells from malignant tumors ...

  6. Laser beam steering for GRACE Follow-On intersatellite interferometry.

    Science.gov (United States)

    Schütze, Daniel; Stede, Gunnar; Müller, Vitali; Gerberding, Oliver; Bandikova, Tamara; Sheard, Benjamin S; Heinzel, Gerhard; Danzmann, Karsten

    2014-10-01

    The GRACE Follow-On satellites will use, for the first time, a Laser Ranging Interferometer to measure intersatellite distance changes from which fluctuations in Earth's geoid can be inferred. We have investigated the beam steering method that is required to maintain the laser link between the satellites. Although developed for the specific needs of the GRACE Follow-On mission, the beam steering method could also be applied to other intersatellite laser ranging applications where major difficulties are common: large spacecraft separation and large spacecraft attitude jitter. The beam steering method simultaneously coaligns local oscillator beam and transmitted beam with the laser beam received from the distant spacecraft using Differential Wavefront Sensing. We demonstrate the operation of the beam steering method on breadboard level using GRACE satellite attitude jitter data to command a hexapod, a six-degree-of-freedom rotation and translation stage. We verify coalignment of local oscillator beam/ transmitted beam and received beam of better than 10 μrad with a stability of 10 μrad/ √Hz in the GRACE Follow-On measurement band of 0.002...0.1 Hz. Additionally, important characteristics of the beam steering setup such as Differential Wavefront Sensing signals, heterodyne efficiency, and suppression of rotation-to-pathlength coupling are investigated and compared with analysis results. PMID:25321987

  7. Quantum steering of Gaussian states via non-Gaussian measurements

    Science.gov (United States)

    Ji, Se-Wan; Lee, Jaehak; Park, Jiyong; Nha, Hyunchul

    2016-01-01

    Quantum steering—a strong correlation to be verified even when one party or its measuring device is fully untrusted—not only provides a profound insight into quantum physics but also offers a crucial basis for practical applications. For continuous-variable (CV) systems, Gaussian states among others have been extensively studied, however, mostly confined to Gaussian measurements. While the fulfilment of Gaussian criterion is sufficient to detect CV steering, whether it is also necessary for Gaussian states is a question of fundamental importance in many contexts. This critically questions the validity of characterizations established only under Gaussian measurements like the quantification of steering and the monogamy relations. Here, we introduce a formalism based on local uncertainty relations of non-Gaussian measurements, which is shown to manifest quantum steering of some Gaussian states that Gaussian criterion fails to detect. To this aim, we look into Gaussian states of practical relevance, i.e. two-mode squeezed states under a lossy and an amplifying Gaussian channel. Our finding significantly modifies the characteristics of Gaussian-state steering so far established such as monogamy relations and one-way steering under Gaussian measurements, thus opening a new direction for critical studies beyond Gaussian regime. PMID:27411853

  8. Characterization of redox proteins using electrochemical methods.

    NARCIS (Netherlands)

    Verhagen, M.F.J.M.

    1995-01-01

    The use of electrochemical techniques in combination with proteins started approximately a decade ago and has since then developed into a powerfull technique for the study of small redox proteins. In addition to the determination of redox potentials, electrochemistry can be used to obtain informatio

  9. Method for characterization of the redox condition of cementitious materials

    Energy Technology Data Exchange (ETDEWEB)

    Almond, Philip M.; Langton, Christine A.; Stefanko, David B.

    2015-12-22

    Disclosed are methods for determining the redox condition of cementitious materials. The methods are leaching methods that utilize an in situ redox indicator that is present in the cementitious materials as formed. The in situ redox indicator leaches from cementitious material and, when the leaching process is carried out under anaerobic conditions can be utilized to determine the redox condition of the material. The in situ redox indicator can exhibit distinct characteristics in the leachate depending upon the redox condition of the indicator.

  10. Redox activity of naphthalene secondary organic aerosol

    Science.gov (United States)

    McWhinney, R. D.; Zhou, S.; Abbatt, J. P. D.

    2013-04-01

    Chamber secondary organic aerosol (SOA) from low-NOx photooxidation of naphthalene by hydroxyl radical was examined with respect to its redox cycling behaviour using the dithiothreitol (DTT) assay. Naphthalene SOA was highly redox active, consuming DTT at an average rate of 118 ± 14 pmol per minute per μg of SOA material. Measured particle-phase masses of the major previously identified redox active products, 1,2- and 1,4-naphthoquinone, accounted for only 21 ± 3% of the observed redox cycling activity. The redox-active 5-hydroxy-1,4-naphthoquinone was identified as a new minor product of naphthalene oxidation, and including this species in redox activity predictions increased the predicted DTT reactivity to 30 ± 5% of observations. Similar attempts to predict redox behaviour of oxidised two-stroke engine exhaust particles by measuring 1,2-naphthoquinone, 1,4-naphthoquinone and 9,10-phenanthrenequinone predicted DTT decay rates only 4.9 ± 2.5% of those observed. Together, these results suggest that there are substantial unidentified redox-active SOA constituents beyond the small quinones that may be important toxic components of these particles. A gas-to-SOA particle partitioning coefficient was calculated to be (7.0 ± 2.5) × 10-4 m3 μg-1 for 1,4-naphthoquinone at 25 °C. This value suggests that under typical warm conditions, 1,4-naphthoquinone is unlikely to contribute strongly to redox behaviour of ambient particles, although further work is needed to determine the potential impact under conditions such as low temperatures where partitioning to the particle is more favourable. As well, higher order oxidation products that likely account for a substantial fraction of the redox cycling capability of the naphthalene SOA are likely to partition much more strongly to the particle phase.

  11. Redox activity of naphthalene secondary organic aerosol

    Directory of Open Access Journals (Sweden)

    R. D. McWhinney

    2013-04-01

    Full Text Available Chamber secondary organic aerosol (SOA from low-NOx photooxidation of naphthalene by hydroxyl radical was examined with respect to its redox cycling behaviour using the dithiothreitol (DTT assay. Naphthalene SOA was highly redox active, consuming DTT at an average rate of 118 ± 14 pmol per minute per μg of SOA material. Measured particle-phase masses of the major previously identified redox active products, 1,2- and 1,4-naphthoquinone, accounted for only 21 ± 3% of the observed redox cycling activity. The redox-active 5-hydroxy-1,4-naphthoquinone was identified as a new minor product of naphthalene oxidation, and including this species in redox activity predictions increased the predicted DTT reactivity to 30 ± 5% of observations. Similar attempts to predict redox behaviour of oxidised two-stroke engine exhaust particles by measuring 1,2-naphthoquinone, 1,4-naphthoquinone and 9,10-phenanthrenequinone predicted DTT decay rates only 4.9 ± 2.5% of those observed. Together, these results suggest that there are substantial unidentified redox-active SOA constituents beyond the small quinones that may be important toxic components of these particles. A gas-to-SOA particle partitioning coefficient was calculated to be (7.0 ± 2.5 × 10−4 m3 μg−1 for 1,4-naphthoquinone at 25 °C. This value suggests that under typical warm conditions, 1,4-naphthoquinone is unlikely to contribute strongly to redox behaviour of ambient particles, although further work is needed to determine the potential impact under conditions such as low temperatures where partitioning to the particle is more favourable. As well, higher order oxidation products that likely account for a substantial fraction of the redox cycling capability of the naphthalene SOA are likely to partition much more strongly to the particle phase.

  12. Steer wrestling : Hemisphere GPS hopes to bring its auto-steering technology to the oilsands

    Energy Technology Data Exchange (ETDEWEB)

    Bentein, J.

    2009-01-15

    Hemisphere GPS has developed a technology to guide giant dump trucks used in oilsand mining operations. The technology offers the possibility to haul oilsands from northern Alberta mines using driverless, remotely-guided trucks. The GPS system would ensure more accuracy than a human operator. The technology has the potential to be commercialized within the next year, and may be adapted for the mining industry. The unmanned technology would help oilsands mine operators lower their labour costs. Hemisphere GPS gained access to the steer-by-wire technology when it purchased the Australian software company Beeline Technologies Pty Ltd. Hemisphere GPS has also developed prototype unmanned drilling rig technology which has considerable potential in the energy industry. The company has won numerous awards in recognition of its commercial achievements in science and technology. 1 fig.

  13. Research on Friction Compensation Control for Electric Power Steering System

    Directory of Open Access Journals (Sweden)

    Shaosong Li

    2016-01-01

    Full Text Available A novel friction compensation control method is proposed to compensate both the dynamic and static friction torque of steering system. The change of EPS assist torque under fixed amplitude friction compensation torque can cause the diver’s steering feeling fuzzy. That is due to the fact that the friction torque felt by driver varies with EPS assist gain. Therefore, a further modified friction compensation control method is proposed based on EPS assist gain to make the driver have similar friction feeling. Finally, computer simulation and vehicle test are performed to verify the effectiveness of adaptation method in the proposed controller. Test results indicate that the proposed controller improved the driver’s steering performance.

  14. Diffraction Efficiency of Thin Film Holographic Beam Steering Devices

    Science.gov (United States)

    Titus, Charles M.; Pouch, John; Nguyen, Hung; Miranda, Felix; Bos, Philip J.

    2003-01-01

    Dynamic holography has been demonstrated as a method for correcting aberrations in space deployable optics, and can also be used to achieve high-resolution beam steering in the same environment. In this paper, we consider some of the factors affecting the efficiency of these devices. Specifically, the effect on the efficiency of a highly collimated beam from the number of discrete phase steps per period is considered for a blazed thin film beam steering grating. The effect of the number of discrete phase steps per period on steering resolution is also considered. We also present some result of Finite-Difference Time-Domain (FDTD) calculations of light propagating through liquid crystal "blazed" gratings. Liquid crystal gratings are shown to spatially modulate both the phase and amplitude of the propagating light.

  15. A Parallel and Distributed Surrogate Model Implementation for Computational Steering

    KAUST Repository

    Butnaru, Daniel

    2012-06-01

    Understanding the influence of multiple parameters in a complex simulation setting is a difficult task. In the ideal case, the scientist can freely steer such a simulation and is immediately presented with the results for a certain configuration of the input parameters. Such an exploration process is however not possible if the simulation is computationally too expensive. For these cases we present in this paper a scalable computational steering approach utilizing a fast surrogate model as substitute for the time-consuming simulation. The surrogate model we propose is based on the sparse grid technique, and we identify the main computational tasks associated with its evaluation and its extension. We further show how distributed data management combined with the specific use of accelerators allows us to approximate and deliver simulation results to a high-resolution visualization system in real-time. This significantly enhances the steering workflow and facilitates the interactive exploration of large datasets. © 2012 IEEE.

  16. Signal Processing Strategies for Cochlear Implants Using Current Steering

    Directory of Open Access Journals (Sweden)

    Waldo Nogueira

    2009-01-01

    Full Text Available In contemporary cochlear implant systems, the audio signal is decomposed into different frequency bands, each assigned to one electrode. Thus, pitch perception is limited by the number of physical electrodes implanted into the cochlea and by the wide bandwidth assigned to each electrode. The Harmony HiResolution bionic ear (Advanced Bionics LLC, Valencia, CA, USA has the capability of creating virtual spectral channels through simultaneous delivery of current to pairs of adjacent electrodes. By steering the locus of stimulation to sites between the electrodes, additional pitch percepts can be generated. Two new sound processing strategies based on current steering have been designed, SpecRes and SineEx. In a chronic trial, speech intelligibility, pitch perception, and subjective appreciation of sound were compared between the two current steering strategies and standard HiRes strategy in 9 adult Harmony users. There was considerable variability in benefit, and the mean results show similar performance with all three strategies.

  17. Electronic Two-Dimensional Beam Steering for Integrated Optical Phased Arrays

    OpenAIRE

    Abiri, Behrooz; Aflatouni, Firooz; Rekhi, Angad; Hajimiri, Ali

    2014-01-01

    This paper presents electrical beam steering in an integrated 4x4 2D optical phased array (OPA) on a silicon on insulator (SOI) process enabling fast and repeatable beam steering for next generation projection, tracking, and imaging.

  18. The interplay between sulphur and selenium metabolism influences the intracellular redox balance in Saccharomyces cerevisiae

    DEFF Research Database (Denmark)

    Mapelli, Valeria; Hillestrøm, Peter René; Patil, Kalpesh;

    2012-01-01

    Selenium (Se) is an essential element for most eukaryotic organisms, including humans. The balance between Se toxicity and its beneficial effects is very delicate. It has been demonstrated that a diet enriched with Se has cancer prevention potential in humans. The most popular commercial Se...... oxidative stress response is active when yeast actively metabolizes Se, and this response is linked to the generation of intracellular redox imbalance. The redox imbalance derives from a disproportionate ratio between the reduced and oxidized forms of glutathione and also from the influence of Se metabolism...

  19. Dynamic Curvature Steering Control for Autonomous Vehicle: Performance Analysis

    Science.gov (United States)

    Aizzat Zakaria, Muhammad; Zamzuri, Hairi; Amri Mazlan, Saiful

    2016-02-01

    This paper discusses the design of dynamic curvature steering control for autonomous vehicle. The lateral control and longitudinal control are discussed in this paper. The controller is designed based on the dynamic curvature calculation to estimate the path condition and modify the vehicle speed and steering wheel angle accordingly. In this paper, the simulation results are presented to show the capability of the controller to track the reference path. The controller is able to predict the path and modify the vehicle speed to suit the path condition. The effectiveness of the controller is shown in this paper whereby identical performance is achieved with the benchmark but with extra curvature adaptation capabilites.

  20. Compact holographic memory using E - O beam steering

    Science.gov (United States)

    Chao, Tien-Hsin; Zhou, Hanying; Reyes, George; Hanan, Jay

    2002-01-01

    An innovative holographic memory system has been developed at JPL for high-density and high speed data storage in a space environment. This system ulitlizes a newly developed electro-optic (E-O) beam steering technology for beam steering to enable high-speed random access memory read/write without moving parts. Recently, a compact CD-sized holographic memory broadboard has been developed and demonstrated for holographic data storage adn retrieval. Detail technical progress will be presented in this paper.

  1. Using brain-computer interface to steer a humanoid robot

    OpenAIRE

    Gergondet P.; Druon S.; Kheddar A.; Hintermuller C.; Guger C.; Slater M.

    2011-01-01

    This work presents the use of a brain-computer interface (BCI) system in order to steer a humanoid robot. We aim at designing a ready-to-use system allowing the user to manipulate the robot in an unknown environment. This design induces some constraints on the BCI system design that we present in this paper. Given these constraints, two steering paradigms based upon the steady-state visually evoked potentials (SSVEP) phenomenon are proposed, implemented on the HRP-2 humanoid robot, and compar...

  2. Effects of slow-release urea on ruminal digesta characteristics and growth performance in beef steers

    DEFF Research Database (Denmark)

    Taylor-Edwards, C C; Hibbard, G; Kitts, S E;

    2009-01-01

    Two experiments were conducted to evaluate the effects of slow urea (SRU) versus feed-grade urea on ruminal metabolite characteristics in steers and DMI, gain, and G:F in growing beef steers.......Two experiments were conducted to evaluate the effects of slow urea (SRU) versus feed-grade urea on ruminal metabolite characteristics in steers and DMI, gain, and G:F in growing beef steers....

  3. Magnetic measurement and analysis of independent and combined function steering magnets for Indus-2

    International Nuclear Information System (INIS)

    Indus-2 is a 2.5 GeV synchrotron light source under construction at CAT, Indore. Storage ring consists of a total 16 dipole, 72 quadrupole, 32 sextupole and 56 steering magnets. Out of these 56 steering magnets, 32 are combined function magnets, 16 horizontal and 8 vertical steering magnets. Results of magnetic measurements of steering magnets are discussed in this paper. (author)

  4. Performance Analysis of the Different Null Steering Techniques in the Field of Adaptive Beamforming

    OpenAIRE

    Fawad Zaman; Bilal Shoaib; Zafar Ullah Khan; Shahid Mehmood

    2013-01-01

    In this study, we compare the performance of three null steering techniques using uniform linear array. These techniques include Null Steering without using Phase Shifters, Null Steering by Decoupling the Real Weights and Null Steering by Decoupling the Complex Weights. The evaluation criteria of these techniques is based on the bases of different parameters i.e., null depth, main beam width, side lobe levels, number of steerable nulls, computational complexity and number of sensors used in t...

  5. Driver steering assistance: lane departure prevention for curvy roads using feedforward correction and BMI optimization

    OpenAIRE

    Minoiu-Enache, N.; Mammar, S.; LUSETTI,B; Netto, M.

    2008-01-01

    This paper presents a steering assistance system that helps the driver to avoid unintended lane departure. Using a DC motor installed on the steering column, a steering control law takes action in situations of drifting off the lane. Furthermore, the steering control law provides lane keeping for straight as well as for curved roads until the driver recovers attention. In order to minimize a potential lane overshoot after the activation moment, and to reduce the curvature effect on the lane k...

  6. Organelle redox autonomy during environmental stress.

    Science.gov (United States)

    Bratt, Avishay; Rosenwasser, Shilo; Meyer, Andreas; Fluhr, Robert

    2016-09-01

    Oxidative stress is generated in plants because of inequalities in the rate of reactive oxygen species (ROS) generation and scavenging. The subcellular redox state under various stress conditions was assessed using the redox reporter roGFP2 targeted to chloroplastic, mitochondrial, peroxisomal and cytosolic compartments. In parallel, the vitality of the plant was measured by ion leakage. Our results revealed that during certain physiological stress conditions the changes in roGFP2 oxidation are comparable to application of high concentrations of exogenous H2 O2 . Under each stress, particular organelles were affected. Conditions of extended dark stress, or application of elicitor, impacted chiefly on the status of peroxisomal redox state. In contrast, conditions of drought or high light altered the status of mitochondrial or chloroplast redox state, respectively. Amalgamation of the results from diverse environmental stresses shows cases of organelle autonomy as well as multi-organelle oxidative change. Importantly, organelle-specific oxidation under several stresses proceeded cell death as measured by ion leakage, suggesting early roGFP oxidation as predictive of cell death. The measurement of redox state in multiple compartments enables one to look at redox state connectivity between organelles in relation to oxidative stress as well as assign a redox fingerprint to various types of stress conditions. PMID:27037976

  7. [Cancer].

    Science.gov (United States)

    de la Peña-López, Roberto; Remolina-Bonilla, Yuly Andrea

    2016-09-01

    Cancer is a group of diseases which represents a significant public health problem in Mexico and worldwide. In Mexico neoplasms are the second leading cause of death. An increased morbidity and mortality are expected in the next decades. Several preventable risk factors for cancer development have been identified, the most relevant including tobacco use, which accounts for 30% of the cancer cases; and obesity, associated to another 30%. These factors, in turn, are related to sedentarism, alcohol abuse and imbalanced diets. Some agents are well knokn to cause cancer such as ionizing radiation, viruses such as the papilloma virus (HPV) and hepatitis virus (B and C), and more recently environmental pollution exposure and red meat consumption have been pointed out as carcinogens by the International Agency for Research in Cancer (IARC). The scientific evidence currently available is insufficient to consider milk either as a risk factor or protective factor against different types of cancer. PMID:27603890

  8. Redox kinetics and mechanism in silicate melts

    International Nuclear Information System (INIS)

    This work contributes to better understand iron redox reactions and mechanisms in silicate melts. It was conducted on compositions in both Na2O-B2O3-SiO2-FeO and Na2O-Al2O3-SiO2-FeO systems. The influence of boron-sodium and aluminum-sodium substitutions and iron content on properties and structure of glasses and on the iron redox kinetics has been studied by Raman, Moessbauer and XANES spectroscopies at the B and Fe K-edges. In borosilicate glasses, an increase in iron content or in the Fe3+/ΣFe redox state implies a structural rearrangement of the BO4 species in the glass network whereas the BO3 and BO4 relative proportions remain nearly constant. In all studied glasses and melts, Fe3+ is a network former in tetrahedral coordination, unless for aluminosilicates of ratio Al/Na≥1 where Fe3+ is a network modifier in five-fold coordination. Near Tg, diffusion of network modifying cations controls the iron redox kinetics along with a flux of electron holes. At liquidus temperatures, oxygen diffusion is considered to be the mechanism that governs redox reactions. This study shows the role played by the silicate network polymerization on the redox kinetics. In borosilicate melts, iron redox kinetics depends on the boron speciation between BO3 and BO4 that depends itself on the sodium content. Furthermore, an increase in the network-former/network-modifier ratio implies a decrease in oxygen diffusion that results in a slowing down of the redox kinetics. The obtained results allow a description of the iron redox kinetics for more complex compositions as natural lavas or nuclear waste model glasses. (author)

  9. 46 CFR 78.47-55 - Instructions for changing steering gear.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 3 2010-10-01 2010-10-01 false Instructions for changing steering gear. 78.47-55... OPERATIONS Markings for Fire and Emergency Equipment, Etc. § 78.47-55 Instructions for changing steering gear..., relating in order, the different steps to be taken in changing to the emergency steering gear. Each...

  10. 46 CFR 35.20-10 - Steering gear test-T/ALL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Steering gear test-T/ALL. 35.20-10 Section 35.20-10... Steering gear test—T/ALL. On all tankships making voyages of more than 48 hours' duration, the entire steering gear, the whistle, the means of communication, and the signaling appliances between the bridge...

  11. 46 CFR 97.37-33 - Instructions for changing steering gear.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Instructions for changing steering gear. 97.37-33... steering gear. (a) Instructions in at least 1/2 inch letters and figures shall be posted in the steering... gear. Each clutch, gear, wheel, lever, valve, or switch which is used during the changeover shall...

  12. Enhancement of the acute phase response to lipopolysaccharide (LPS) challenge in steers supplemented with chromium

    Science.gov (United States)

    The study examined the effect of chromium supplementation on the response of steers to an LPS challenge. Twenty steers received a premix that added 0 (control) or 0.2 mg/kg of chromium (KemTRACE®brandChromiumProprionate 0.04%, Kemin Industries) to the total diet on a dry matter basis for 55 d. Steer...

  13. Chromium supplementation enhances the acute phase response of steers to a lipopolysaccharide (LPS) challenge

    Science.gov (United States)

    The study examined the effect of chromium supplementation on the response of steers to an LPS challenge. Twenty crossbred steers (235±4 kg BW) received 0 ppb (Control; C) or 200 ppb chromium propionate (CHR) for 55 days. Steers were fitted with jugular catheters and rectal temperature (RT) recording...

  14. Scanning electrochemical microscopy of living cells: different redox activities of nonmetastatic and metastatic human breast cells.

    Science.gov (United States)

    Liu, B; Rotenberg, S A; Mirkin, M V

    2000-08-29

    Electrochemical methods have been widely used to monitor physiologically important molecules in biological systems. This report describes the first application of the scanning electrochemical microscope (SECM) to probe the redox activity of individual living cells. The possibilities of measuring the rate and investigating the pathway of transmembrane charge transfer are demonstrated. By this approach, significant differences are detected in the redox responses given by nonmotile, nontransformed human breast epithelial cells, breast cells with a high level of motility (engendered by overexpression of protein kinase Calpha), and highly metastatic breast cancer cells. SECM analysis of the three cell lines reveals reproducible differences with respect to the kinetics of charge transfer by several redox mediators. PMID:10963658

  15. Redox-mediated bypass of restriction point via skipping of G1pm

    Directory of Open Access Journals (Sweden)

    Greene James J

    2006-07-01

    Full Text Available Abstract Background It is well known that cancer cells bypass the restriction point, R, and undergo uncontrolled cell proliferation. Hypothesis and evidence We suggest here that fibrosarcoma cells enter G1ps directly from M, skipping G1pm, hence bypassing R, in response to redox modulation. Evidence is presented from the published literature that demonstrate a shortening of the cycle period of transformed fibroblasts (SV-3T3 compared to the nontransformed 3T3 fibroblasts, corresponding to the duration of G1pm in the 3T3 fibroblasts. Evidence is also presented that demonstrate that redox modulation can induce the CUA-4 fibroblasts to bypass R, resulting in a cycle period closely corresponding to the cycle period of fibrosarcoma cells (HT1080. Conclusion The evidence supports our hypothesis that a low internal redox potential can cause fibrosarcoma cells to skip the G1pm phase of the cell cycle.

  16. DSPIC BASED POWER ASSISTED STEERING USING BRUSHLESS DIRECT CURRENT MOTOR

    Directory of Open Access Journals (Sweden)

    G. R.P. Lakshmi

    2013-01-01

    Full Text Available This study illustrates the Electrically Assisted power Steering (EAS using BLDC motor for a vehicle. Earlier the Electrically Assisted power Steering (EAS was implemented with DSP. This study shows the usage of a dsPIC to control the BLDC motor with an encoder. The BLDC motor here is driven by dsPIC through a three phase inverter system. IRAMS type of inverter is used which is cost efficient and space efficient. The dsPIC supplied with the input of the steering. In its higher capacity the vehicles speed controller acts as the assistance level controller for steering effort. At the lower capacity, the torque controller gives the effort level control. In reality this can be realized as torque sensor and vehicle sensor interfaced in the dsPIC. For actual implementation in the system, a dsPIC-based BLDC motor controller with three-phase inverter module is used with Hall-effect sensor feedback. It is designed in such a way that the driver assistance can be varied at any time without any difficulty.

  17. Slow-release urea in supplement fed to beef steers

    Directory of Open Access Journals (Sweden)

    Ana Paula Gonçalves

    2015-02-01

    Full Text Available Replacing regular urea (RU by slow-release urea (SRU at two levels of non-protein nitrogen (NPN in concentrate, offered with low-quality roughage, was evaluated in beef steers on dry matter intake (DMI, ruminal fermentation parameters, plasma urea nitrogen (PUN, total tract apparent digestibility of diets and in situ degradability of nitrogen sources. Eight ruminally cannulated steers were allocated into two 4x4 Latin squares, totalizing four treatments: 40 NPN/0 SRU: 40% of concentrate crude protein (CP as NPN, resulting from 0% of SRU and 100% of RU; 40 NPN/50 SRU: 40% of concentrate CP as NPN, resulting from 50% of SRU and 50% of RU; 40 NPN/100 SRU: 40% of concentrate CP as NPN, resulting from 100% of SRU and 0% of RU; 80 NPN/100 SRU: 80% of concentrate CP as NPN, resulting from 100% of SRU and 0% of RU. Results showed that partial substitution of regular urea by slow-release urea did not alter dry matter intake, pattern of ruminal fermentation or plasma urea nitrogen concentrations and increased the total tract apparent digestibility of crude protein in steers diets. The increase in non-protein nitrogen content in crude protein of the concentrate could compromise feed intake and the efficiency of nutrient utilization in the steers fed complete diets based on low quality forage.

  18. Programmable agile beam steering based on a liquid crystal prism

    International Nuclear Information System (INIS)

    To meet the application need for agile precision beam steering, a novel liquid crystal prism device with a simple structure, convenient control, low cost and applicable performance is presented, and analysed theoretically and experimentally. The relationships between the optical path and the thickness of the liquid crystal cell under different voltages are investigated quantitatively by using a theoretical model. Analysis results show that the optical path profile of the liquid crystal prism has a quasi-linear slope and the standard deviation of the linear slope is less than 16 nm. The slope ratio can be changed by a voltage, which achieves the programmable beam steering and control. Practical liquid crystal prism devices are fabricated. Their deflection angles and wavefront profiles with different voltages are experimentally tested. The results are in good agreement with the simulated results. The results imply that the agile beam steering in a scope of 100 μrad with a micro-rad resolution is substantiated in the device. The two-dimensional beam steering is also achieved by cascading two liquid crystal prism devices. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  19. Image Processing In Laser-Beam-Steering Subsystem

    Science.gov (United States)

    Lesh, James R.; Ansari, Homayoon; Chen, Chien-Chung; Russell, Donald W.

    1996-01-01

    Conceptual design of image-processing circuitry developed for proposed tracking apparatus described in "Beam-Steering Subsystem For Laser Communication" (NPO-19069). In proposed system, desired frame rate achieved by "windowed" readout scheme in which only pixels containing and surrounding two spots read out and others skipped without being read. Image data processed rapidly and efficiently to achieve high frequency response.

  20. Mechanics of Flexible Needles Robotically Steered through Soft Tissue

    NARCIS (Netherlands)

    Misra, S.; Reed, K.B.; Schafer, B.W.; Ramesh, K.T.; Okamura, A.M.

    2010-01-01

    The tip asymmetry of a bevel-tip needle results in the needle naturally bending when it is inserted into soft tissue. This enables robotic needle steering, which can be used in medical procedures to reach subsurface targets inaccessible by straight-line trajectories. However, accurate path planning

  1. Phase control and beam steering of semiconductor laser arrays

    Science.gov (United States)

    Katz, J.

    1982-01-01

    The operational principles and a possible device configuration of one dimensional monolithically integrated semiconductor laser arrays are described. The output beam of the array can be electronically steered. Devices of the type can find applications in optical communication systems where the power levels needed are above the capability of a single laser device.

  2. Liquid Crystal-based Beam Steering Technologies for NASA Applications

    Science.gov (United States)

    Pouch, John; Nguyen, Hung; Miranda, Felix; Bos, Philip; Lavrentovich, Oleg; Wang, Xinghua; Pishnyak, Oleg; Kreminska, Liubov; Golovin, Andrii

    2006-01-01

    Liquid crystal-based beam steering devices can provide electronic beam scanning to angles above 1 milliradian, sub-microradian beam pointing accuracy, as well as wave-front correction to maintain output optical beam quality. The liquid crystal technology effort will be summarized, and the potential application of the resulting devices to NASA space-based scenarios will be described.

  3. Semiconductor Laser With Two-Dimensional Beam Steering

    Science.gov (United States)

    Katz, J.

    1986-01-01

    Modification of monolithic semiconductor injection laser capable of one-dimensional electronic beam steering enables deflection of beam in second direction. Such laser chip provides beam pointing or raster scanning for applications in optical communications, data processing, image scanning, and optical ranging.

  4. Power-dependent soliton steering in thermal nonlinear media

    OpenAIRE

    Ye, Fangwei; Kartashov, Yaroslav V.; Hu, Bambi; Torner, Lluis

    2009-01-01

    We address the existence and properties of optical solitons excited in thermal nonlinear media with a transverse refractive index gradient. We show that in such a geometry one can generate controllable switching from surface soliton propagating near the sample edges to bulk solitons. Beam steering associated to the different soliton output locations can be achieved by varying the input light intensity.

  5. Minutes: ANSI Steering Committee on Solar Energy Standards Development

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-04-29

    Minutes of the April 29, 1980, meeting of the American National Standards Institute steering committee on solar energy standards development are given. Attachments include correspondence from individuals and organizations which primarily describe the Solar Public Interest Coordination Committee (SPICC) and its recent activities. Also a report on the meeting of the ANSI subcommittee on international activity is attached. (WHK)

  6. The Analysis of The Fault of Electrical Power Steering

    Directory of Open Access Journals (Sweden)

    Zhang Li Wen

    2016-01-01

    Full Text Available This paper analysis the common fault types of primary Electrical Power Steering system, meanwhile classify every fault. It provides the basis for further troubleshooting and maintenance. At the same time this paper propose a practical working principle of fault-tolerant, in order to make the EPS system more security and durability.

  7. MODELING OF VEHICULAR STEERING EFFICIENCY IN TRAFFIC DIRECTION MOTION CHANNEL

    OpenAIRE

    V. A. Ganai; S. A. O. Diab Abdullah

    2011-01-01

    The paper formulates and solves an actual problem pertaining to vehicular steering efficiency in traffic direction motion channel. Models of operator-drivers with low, medium and high rates in motivational perception of road conditions and also a model for controlling a traffic direction motion have been taken into ccount in the paper.  Modeling has been done by using MATLAB.

  8. Periodic Exposure of Keratinocytes to Cold Physical Plasma: An In Vitro Model for Redox-Related Diseases of the Skin

    Directory of Open Access Journals (Sweden)

    Anke Schmidt

    2016-01-01

    Full Text Available Oxidative stress illustrates an imbalance between radical formation and removal. Frequent redox stress is critically involved in many human pathologies including cancer, psoriasis, and chronic wounds. However, reactive species pursue a dual role being involved in signaling on the one hand and oxidative damage on the other. Using a HaCaT keratinocyte cell culture model, we investigated redox regulation and inflammation to periodic, low-dose oxidative stress after two, six, eight, ten, and twelve weeks. Chronic redox stress was generated by recurrent incubation with cold physical plasma-treated cell culture medium. Using transcriptome microarray technology, we identified both acute ROS-stress responses as well as numerous adaptions after several weeks of redox challenge. We determined a differential expression (2-fold, FDR < 0.01, p<0.05 of 260 genes that function in inflammation and redox homeostasis, such as cytokines (e.g., IL-6, IL-8, and IL-10, growth factors (e.g., CSF2, FGF, and IGF-2, and antioxidant enzymes (e.g., HMOX, NQO1, GPX, and PRDX. Apoptotic signaling was affected rather modestly, especially in p53 downstream targets (e.g., BCL2, BBC3, and GADD45. Strikingly, the cell-protective heat shock protein HSP27 was strongly upregulated (p<0.001. These results suggested cellular adaptions to frequent redox stress and may help to better understand the inflammatory responses in redox-related diseases.

  9. Redox potential tuning by redox-inactive cations in nature's water oxidizing catalyst and synthetic analogues.

    Science.gov (United States)

    Krewald, Vera; Neese, Frank; Pantazis, Dimitrios A

    2016-04-20

    The redox potential of synthetic oligonuclear transition metal complexes has been shown to correlate with the Lewis acidity of a redox-inactive cation connected to the redox-active transition metals of the cluster via oxo or hydroxo bridges. Such heterometallic clusters are important cofactors in many metalloenzymes, where it is speculated that the redox-inactive constituent ion of the cluster serves to optimize its redox potential for electron transfer or catalysis. A principal example is the oxygen-evolving complex in photosystem II of natural photosynthesis, a Mn4CaO5 cofactor that oxidizes water into dioxygen, protons and electrons. Calcium is critical for catalytic function, but its precise role is not yet established. In analogy to synthetic complexes it has been suggested that Ca(2+) fine-tunes the redox potential of the manganese cluster. Here we evaluate this hypothesis by computing the relative redox potentials of substituted derivatives of the oxygen-evolving complex with the cations Sr(2+), Gd(3+), Cd(2+), Zn(2+), Mg(2+), Sc(3+), Na(+) and Y(3+) for two sequential transitions of its catalytic cycle. The theoretical approach is validated with a series of experimentally well-characterized Mn3AO4 cubane complexes that are structural mimics of the enzymatic cluster. Our results reproduce perfectly the experimentally observed correlation between the redox potential and the Lewis acidities of redox-inactive cations for the synthetic complexes. However, it is conclusively demonstrated that this correlation does not hold for the oxygen evolving complex. In the enzyme the redox potential of the cluster only responds to the charge of the redox-inactive cations and remains otherwise insensitive to their precise identity, precluding redox-tuning of the metal cluster as a primary role for Ca(2+) in biological water oxidation. PMID:26762578

  10. Glutathione and redox signaling in substance abuse.

    Science.gov (United States)

    Uys, Joachim D; Mulholland, Patrick J; Townsend, Danyelle M

    2014-07-01

    Throughout the last couple decades, the cause and consequences of substance abuse has expanded to identify the underlying neurobiological signaling mechanisms associated with addictive behavior. Chronic use of drugs, such as cocaine, methamphetamine and alcohol leads to the formation of oxidative or nitrosative stress (ROS/RNS) and changes in glutathione and redox homeostasis. Of importance, redox-sensitive post-translational modifications on cysteine residues, such as S-glutathionylation and S-nitrosylation could impact on the structure and function of addiction related signaling proteins. In this commentary, we evaluate the role of glutathione and redox signaling in cocaine-, methamphetamine- and alcohol addiction and conclude by discussing the possibility of targeting redox pathways for the therapeutic intervention of these substance abuse disorders. PMID:25027386

  11. Symproportionation versus Disproportionation in Bromine Redox Systems

    International Nuclear Information System (INIS)

    Graphical abstract: Display Omitted -- Highlights: • The disproportionation and symproportionation of bromine in different media is presented. • All the redox systems are elaborated according to the principles of the generalized approach to electrolytic redox systems (GATES/GEB). • All physicochemical knowledge is involved in the algorithm applied for this purpose. • The graphical representation of the systems is the basis of gaining the detailed physicochemical knowledge on the systems in question. -- Abstract: The paper refers to dynamic (titration) redox systems where symproportionation or disproportionation of bromine species occur. The related systems are modeled according to principles assumed in the Generalized Approach to Electrolytic Redox Systems (GATES), with Generalized Electron Balance (GEB) concept involved in the GATES/GEB software. The results obtained from calculations made with use of iterative computer programs prepared according to MATLAB computational software, are presented graphically, as 2D and 3D graphs

  12. High energy density redox flow device

    Energy Technology Data Exchange (ETDEWEB)

    Chiang, Yet-Ming; Carter, W. Craig; Ho, Bryan Y; Duduta, Mihai; Limthongkul, Pimpa

    2014-05-13

    Redox flow devices are described in which at least one of the positive electrode or negative electrode-active materials is a semi-solid or is a condensed ion-storing electroactive material, and in which at least one of the electrode-active materials is transported to and from an assembly at which the electrochemical reaction occurs, producing electrical energy. The electronic conductivity of the semi-solid is increased by the addition of conductive particles to suspensions and/or via the surface modification of the solid in semi-solids (e.g., by coating the solid with a more electron conductive coating material to increase the power of the device). High energy density and high power redox flow devices are disclosed. The redox flow devices described herein can also include one or more inventive design features. In addition, inventive chemistries for use in redox flow devices are also described.

  13. Oscillation and deterministic chaos in redox reactions

    Czech Academy of Sciences Publication Activity Database

    Pospíšil, Lubomír; Hromadová, Magdaléna; Fanelli, N.; Valášek, Michal

    Bourgogne : Université de Bourgogne, 2012. s. 20-20. [French-Czech Vltava Chemistry Meeting /3./. 10.09.2012-11.09.2012, Dijon] Institutional support: RVO:61388955 ; RVO:61388963 Keywords : oscillation * redox reactions Subject RIV: CG - Electrochemistry

  14. Comparing Ultrasound and Mechanical Steering in a Biodiesel Production Process

    Science.gov (United States)

    Costa-Felix, Rodrigo P. B.; Ferreira, Jerusa R. L.

    The analysis of the kinetics of the transesterification reaction is crucial to compare different routes or routes with different catalysts or reaction accelerators. The use of ultrasound is considereda method for accelerating the biodiesel production. However, little effort has been done and is reported in the literature about how and under what conditions the use of ultrasound really speeds up the process, or the conditions under which its use is unnecessary or even harmful, burdening the process. Two dissimilar energy injections into a typical route were tested: ultrasound (@ 1 MHz and no heating) and mechanical steering (with heating), both applied in an 8:1 ratio of soybean oil and methanol, adding 1% of KOH as catalyzer. As results, during the first 10 minutes of reaction ultrasound showed unbearable effect on the transesterification, whilst mechanical steering and heating achieved almost 70% of conversion ratio. However, during the following 10 minutes, the mechanical steering and heating got nothing more than 80% of conversion, a considerable less efficient process than ultrasound assisted one, which achieved more than 90%. The straightforward explanation is that ultrasound continually inserts energy in a slower rate, what can result in a more stable conversion scenario. On the other hand, mechanical steering and heating provides more energy at a glance, but cannot push the final conversion rate beyond a limit, as the transesterification is a double-way chemical process. The instability mechanical steering and heating settles in the reaction medium pulls the components back to their original states more than pushes than to the converted equilibrium state of the matter.

  15. Active steering system for the neutral beam injector for ITER

    International Nuclear Information System (INIS)

    ITER requires an additional power injection of 33 MW from neutral beams, which can be provided by two injectors, delivering 16.5 MW each, having an ion current of 40 A and an accelerating voltage of 1 MV. The requirement of on-axis and off-axis injection into ITER is presently accomplished by mechanical tilting of the injector source. To preserve the integrity of the beam line components, on the horizontal plane, very tight misalignment is tolerable (±3 mrad); such accuracy requires precise installation of the components. Breaking the vacuum and executing a long series of operations is required to provide proper beam alignment. It would be helpful if such alignments could be performed remotely. A study has been conducted on the possibility of steering the negative ions by suitable magnetic fields, generated by dedicated coils located at the exit of the accelerator. It results that the magnetic system can meet the requirements in terms of beam alignment. The steering system will heavily affect the trajectory of the electrons extracted from the accelerator and can be used to deflect the electrons onto suitable dump plates. The system can steer the ions and dump the electrons in a controlled way, even in case of modulation of the acceleration voltage; a flexible beam aiming system can be used to adapt the power deposition profile in ITER to the plasma characteristics; active steering can provide a suitable way to control the power deposition with respect to the possibility of exciting Alfven eigenmodes, which can reduce the performances of ITER plasmas. The present contribution reviews the preliminary design of the active steering system and provides an analysis of advantages and disadvantages. (author)

  16. Redox-Dependent Conformational Switching of Diphenylacetylenes

    Directory of Open Access Journals (Sweden)

    Ian M. Jones

    2014-07-01

    Full Text Available Herein we describe the design and synthesis of a redox-dependent single-molecule switch. Appending a ferrocene unit to a diphenylacetylene scaffold gives a redox-sensitive handle, which undergoes reversible one-electron oxidation, as demonstrated by cyclic voltammetry analysis. 1H-NMR spectroscopy of the partially oxidized switch and control compounds suggests that oxidation to the ferrocenium cation induces a change in hydrogen bonding interactions that results in a conformational switch.

  17. Measurement of Redox Potential in Nanoecotoxicological Investigations

    OpenAIRE

    Dipak Gohil; Jacqueline Snowden; Roger Peck; Alex Cackett; Ratna Tantra

    2012-01-01

    Redox potential has been identified by the Organisation for Economic Co-operation and Development (OECD) as one of the parameters that should be investigated for the testing of manufactured nanomaterials. There is still some ambiguity concerning this parameter, i.e., as to what and how to measure, particularly when in a nanoecotoxicological context. In this study the redox potentials of six nanomaterials (either zinc oxide (ZnO) or cerium oxide (CeO2)) dispersions were measured using an oxida...

  18. Redox signaling in cardiovascular health and disease

    OpenAIRE

    Madamanchi, Nageswara R.; Runge, Marschall S.

    2013-01-01

    Spatiotemporal regulation of the activity of a vast array of intracellular proteins and signaling pathways by reactive oxygen species (ROS) governs normal cardiovascular function. However, data from experimental and animal studies strongly support that dysregulated redox signaling, resulting from hyper-activation of various cellular oxidases or mitochondrial dysfunction, is integral to the pathogenesis and progression of cardiovascular disease (CVD). In this review, we address how redox signa...

  19. Membranes for redox flow battery applications.

    Science.gov (United States)

    Prifti, Helen; Parasuraman, Aishwarya; Winardi, Suminto; Lim, Tuti Mariana; Skyllas-Kazacos, Maria

    2012-01-01

    The need for large scale energy storage has become a priority to integrate renewable energy sources into the electricity grid. Redox flow batteries are considered the best option to store electricity from medium to large scale applications. However, the current high cost of redox flow batteries impedes the wide spread adoption of this technology. The membrane is a critical component of redox flow batteries as it determines the performance as well as the economic viability of the batteries. The membrane acts as a separator to prevent cross-mixing of the positive and negative electrolytes, while still allowing the transport of ions to complete the circuit during the passage of current. An ideal membrane should have high ionic conductivity, low water intake and excellent chemical and thermal stability as well as good ionic exchange capacity. Developing a low cost, chemically stable membrane for redox flow cell batteries has been a major focus for many groups around the world in recent years. This paper reviews the research work on membranes for redox flow batteries, in particular for the all-vanadium redox flow battery which has received the most attention. PMID:24958177

  20. Membranes for Redox Flow Battery Applications

    Directory of Open Access Journals (Sweden)

    Maria Skyllas-Kazacos

    2012-06-01

    Full Text Available The need for large scale energy storage has become a priority to integrate renewable energy sources into the electricity grid. Redox flow batteries are considered the best option to store electricity from medium to large scale applications. However, the current high cost of redox flow batteries impedes the wide spread adoption of this technology. The membrane is a critical component of redox flow batteries as it determines the performance as well as the economic viability of the batteries. The membrane acts as a separator to prevent cross-mixing of the positive and negative electrolytes, while still allowing the transport of ions to complete the circuit during the passage of current. An ideal membrane should have high ionic conductivity, low water intake and excellent chemical and thermal stability as well as good ionic exchange capacity. Developing a low cost, chemically stable membrane for redox flow cell batteries has been a major focus for many groups around the world in recent years. This paper reviews the research work on membranes for redox flow batteries, in particular for the all-vanadium redox flow battery which has received the most attention.

  1. Development of active rear steer actuator. Development of four wheel steer actuator for active safety; Active rear steer actuator no kaihatsu. Yobo anzen ni muketa 4WS actuator no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    Yamanaka, T. [Aisin Seiki Co. Ltd., Aichi (Japan)

    1997-10-01

    Recently, ecology, energy saving and safety have become important issues. And Active Safety is spotlighted in vehicle control area. Many researches and developments on four wheel steer system have been done to improve vehicle stability. We have developed the Active Rear Steer system with electromechanical Actuator, which is mass-productive, compact, and high response and durable. 10 figs., 5 tabs.

  2. DCP's Early Detection Research Guides Future Science | Division of Cancer Prevention

    Science.gov (United States)

    Early detection research funded by the NCI's Division of Cancer Prevention has positively steered both public health and clinical outcomes, and set the stage for findings in the next generation of research. |

  3. Redox interplay between mitochondria and peroxisomes

    Directory of Open Access Journals (Sweden)

    Celien eLismont

    2015-05-01

    Full Text Available Reduction-oxidation or ‘redox’ reactions are an integral part of a broad range of cellular processes such as gene expression, energy metabolism, protein import and folding, and autophagy. As many of these processes are intimately linked with cell fate decisions, transient or chronic changes in cellular redox equilibrium are likely to contribute to the initiation and progression of a plethora of human diseases. Since a long time, it is known that mitochondria are major players in redox regulation and signaling. More recently, it has become clear that also peroxisomes have the capacity to impact redox-linked physiological processes. To serve this function, peroxisomes cooperate with other organelles, including mitochondria. This review provides a comprehensive picture of what is currently known about the redox interplay between mitochondria and peroxisomes in mammals. We first outline the pro- and antioxidant systems of both organelles and how they may function as redox signaling nodes. Next, we critically review and discuss emerging evidence that peroxisomes and mitochondria share an intricate redox-sensitive relationship and cooperate in cell fate decisions. Key issues include possible physiological roles, messengers, and mechanisms. We also provide examples of how data mining of publicly-available datasets from ‘omics’ technologies can be a powerful means to gain additional insights into potential redox signaling pathways between peroxisomes and mitochondria. Finally, we highlight the need for more studies that seek to clarify the mechanisms of how mitochondria may act as dynamic receivers, integrators, and transmitters of peroxisome-derived mediators of oxidative stress. The outcome of such studies may open up exciting new avenues for the community of researchers working on cellular responses to organelle-derived oxidative stress, a research field in which the role of peroxisomes is currently highly underestimated and an issue of

  4. Hydrogen peroxide regulates cell adhesion through the redox sensor RPSA.

    Science.gov (United States)

    Vilas-Boas, Filipe; Bagulho, Ana; Tenente, Rita; Teixeira, Vitor H; Martins, Gabriel; da Costa, Gonçalo; Jerónimo, Ana; Cordeiro, Carlos; Machuqueiro, Miguel; Real, Carla

    2016-01-01

    To become metastatic, a tumor cell must acquire new adhesion properties that allow migration into the surrounding connective tissue, transmigration across endothelial cells to reach the blood stream and, at the site of metastasis, adhesion to endothelial cells and transmigration to colonize a new tissue. Hydrogen peroxide (H2O2) is a redox signaling molecule produced in tumor cell microenvironment with high relevance for tumor development. However, the molecular mechanisms regulated by H2O2 in tumor cells are still poorly known. The identification of H2O2-target proteins in tumor cells and the understanding of their role in tumor cell adhesion are essential for the development of novel redox-based therapies for cancer. In this paper, we identified Ribosomal Protein SA (RPSA) as a target of H2O2 and showed that RPSA in the oxidized state accumulates in clusters that contain specific adhesion molecules. Furthermore, we showed that RPSA oxidation improves cell adhesion efficiency to laminin in vitro and promotes cell extravasation in vivo. Our results unravel a new mechanism for H2O2-dependent modulation of cell adhesion properties and identify RPSA as the H2O2 sensor in this process. This work indicates that high levels of RPSA expression might confer a selective advantage to tumor cells in an oxidative environment. PMID:26603095

  5. Formulation of general criterion distinguishing between non-redox and redox systems

    International Nuclear Information System (INIS)

    Graphical abstract: - Highlights: • The Generalized Electron Balance (GEB) is considered as a Law of Nature. • A new criterion distinguishing redox and non-redox systems is presented. • Two equivalent approaches to formulation of GEB are presented. • GEB is applicable for electrolytic redox systems of any degree of complexity. - Abstract: The paper provides a comprehensive, compatible and consistent approach to thermodynamics of electrolytic redox and non-redox systems, referred to aqueous, non-aqueous and mixed-solvent media. It is stated that the linear combination 2·f(O) − f(H) of elemental balances: f(H) for H and f(O) for O is the property distinguishing between redox and non-redox electrolytic systems. Namely, 2·f(O) − f(H) is the linear combination of concentration balances for other components of a non-redox system, of any degree of complexity. It is also proved that 2·f(O) − f(H) is an independent equation when referred to a redox system, of any degree of complexity. The linear combination 2·f(O) − f(H) is a primary form, pr-GEB, of the Generalized Electron Balance (GEB), 2·f(O) − f(H) = pr-GEB, named as the Approach II, and considered as the alternative for the Approach I to GEB, based on the “card game” principle. The equivalency of both approaches to GEB is also proved in this paper. The GEB, considered as a relatively new Law of Nature, is perceived as a turning point in the theory of electrolytic redox systems

  6. The Midas touch: automatic steering for longwall shearers

    Energy Technology Data Exchange (ETDEWEB)

    1986-10-01

    Automatic steering for longwall shearers has helped many mines produce record tonnages. British Coal's Machine Information Display and Automation System (MIDAS) has been designed to provide automatic steering for both single and double-ended ranging drum shearers. Describes the Midas unit which is installed in the shearer and which performs all control computation. The main objective is to maintain a constant roof coal thickness and work to a constant seam height. The use of the natural radiation sensors places some limitations on the use of the MIDAS system as the seam must have a shale overburden to emit the necessary natural gammas. Describes the fully automatic, degraded automatic and manual operating modes, the early trials of MIDAS and the use of MIDAS at Silverwood Colliery.

  7. Terrestrial Steering Group. 2014. Arctic Terrestrial Biodiversity Monitoring Plan

    DEFF Research Database (Denmark)

    Aastrup, Peter; Aronsson, Mora; Barry, Tom;

    implementation of the Arctic Terrestrial Biodiversity Monitoring Plan for the next two years. Identify expert networks required for successful implementation of the plan. Identify key gaps and opportunities for the TSG related to plan implementation and identify near-term next steps to address gaps.......The Terrestrial Steering Group (TSG), has initiated the implementation phase of the CBMP Terrestrial Plan. The CBMP Terrestrial Steering Group, along with a set of invited experts (see Appendix A for a participants list), met in Iceland from February 25-27th to develop a three year work plan to...... guide implementation of the CBMP-Terrestrial Plan. This report describes the outcome of that workshop. The aim of the workshop was to develop a three year work plan to guide implementation of the CBMP-Terrestrial Plan. The participants were tasked with devising an approach to both (a) determine what...

  8. Conceptual design of a beam steering lens through transformation electromagnetics.

    Science.gov (United States)

    Yi, Jianjia; Burokur, Shah Nawaz; de Lustrac, André

    2015-05-18

    In this paper, based on transformation electromagnetics, the design procedure of a lens antenna, which steers the radiated beam of a patch array, is presented. Laplace's equation is adopted to construct the mapping between the virtual space and the physical space. The two dimensional (2D) design method can be extended to a potential three-dimensional (3D) realization, and with a proper parameter simplification, the lens can be further realized by common metamaterials or isotropic graded refractive index (GRIN) materials. Full wave simulations are performed to validate the proposed concept. It is observed that by placing the lens on a feeding source, we are able to steer the radiation emitted by the latter source. PMID:26074547

  9. Comparison between various beam steering algorithms for the CEBAF lattice

    International Nuclear Information System (INIS)

    In this paper we describe a comparative study performed to evaluate various beam steering algorithms for CEBAF lattice. The first approach that was evaluated used a Singular Value Decomposition (SVD) based algorithm to determine the corrector magnet setting for various regions of the CEBAF lattice. The second studied algorithm is known as PROSAC (Projective RMS Orbit Subtraction And Correction). This algorithm was developed at TJNAF to support the commissioning activity. The third set of algorithms tested are known as COCU (CERN Orbit Correction Utility) which is a production steering package used at CERN. A program simulating a variety of errors such as misalignment, BPM offset, etc. was used to generate test inputs for these three sets of algorithms. Conclusions of this study are presented in this paper. copyright 1997 American Institute of Physics

  10. Comparison between various beam steering algorithms for the CEBAF lattice

    International Nuclear Information System (INIS)

    In this paper we describe a comparative study performed to evaluate various beam steering algorithms for CEBAF lattice. The first approach that was evaluated used a Singular Value Decomposition (SVD) based algorithm to determine the corrector magnet setting for various regions of the CEBAF lattice. The second studied algorithm is known as PROSAC (Projective RMS Orbit Subtraction And Correction). This algorithm was developed at TJNAF to support the commissioning activity. The third set of algorithms tested are known as COCU (CERN Orbit Correction Utility) which is a production steering package used at CERN. A program simulating a variety of errors such as misalignment, BPM offset, etc. was used to generate test inputs for these three sets of algorithms. Conclusions of this study are presented in this paper

  11. Steering of Educational Processes in a Digital Medium Environment

    DEFF Research Database (Denmark)

    Tække, Jesper; Paulsen, Michael Eric

    2016-01-01

    This paper is about challenges to steering and leadership of educational interaction in classrooms provided by the new medium environment that comes with digital media. In the new medium environment, the old way of steering what is going on in the classroom appears not to work since...... by systems theory we outline a more adequate way of teaching in the new medium environment – a teaching that can manage the new situation and use the new possibilities provided by the digital media. The argumentation builds on empirical findings from the action research project Socio Media Education (SME...... it was developed in the image of the industrial society and based on a closed classroom. Now with the digital media and wireless networks the classroom is opened and the old way of organizing teaching has become inadequate: The students are disturbed by the new media, instead of learning through them. Inspired...

  12. Development of Estimation Force Feedback Torque Control Algorithm for Driver Steering Feel in Vehicle Steer by Wire System: Hardware in the Loop

    Directory of Open Access Journals (Sweden)

    Sheikh Muhammad Hafiz Fahami

    2015-01-01

    Full Text Available In conventional steering system, a feedback torque is produced from the contact between tire and road surface and its flows through mechanical column shaft directly to driver. This allows the driver to sense the steering feel during driving. However, in steer by wire (SBW system, the elimination of the mechanical column shaft requires the system to generate the feedback torque which should produce similar performance with conventional steering system. Therefore, this paper proposes a control algorithm to create the force feedback torque for SBW system. The direct current measurement approach is used to estimate torque at the steering wheel and front axle motor as elements to the feedback torque, while, adding the compensation torque for a realistic feedback torque. The gain scheduling with a linear quadratic regulator controller is used to control the feedback torque and to vary a steering feel gain. To investigate the effectiveness of the proposed algorithm, a real-time hardware in the loop (HIL methodology is developed using Matlab XPC target toolbox. The results show that the proposed algorithm is able to generate the feedback torque similar to EPS steering system. Furthermore, the compensation torque is able to improve the steering feel and stabilize the system.

  13. Redox-flow battery of actinide complexes

    International Nuclear Information System (INIS)

    Np battery and U battery were developed. We suggested that Np redox-flow battery should be (-)|Np3+,Np4+||NpO2+,NpO22+|(+), and U battery (-)|[UIIIT2]-,[UIVT2]0||[UVO2T]-,[UVIO2T]0|(+). The electromotive force at 50 % charge of Np and U battery is 1.10 V and 1.04 V, respectively. The energy efficiency of 70 mA/cm2 of Np and U battery shows 99 % and 98 %, respectively. V redox-flow battery, electrode reactions of An battery, Np battery, U battery and future of U battery are described. The concept of V redox-flow battery, comparison of energy efficiency of Np, U and V battery, oxidation state and ionic species of 3d transition metals and main An, Purbe diagram of Np and U aqueous solution, shift of redox potential of β-diketones by pKa, and specifications of three redox-flow batteries are reported. (S.Y.)

  14. Robust vehicle steering control design based on the disturbance observer

    OpenAIRE

    Bünte, T.; Odenthal, D.; Aksun-Güvenc, B.; Güvenc, L.

    2001-01-01

    A robust steering controller is introduced for improving the yaw dynamics of a passenger car. A specific two degree of freedom control architecture known as the disturbance observer is adapted to the vehicle yaw dynamics control problem and shown to robustly improve performance. The relevant design specifications are formulated in terms of eigenvalues (T-stability) and in frequency domain as bounds on weighted sensitivity and complementary sensitivity functions (B-stability). The parameter sp...

  15. Observation of one-way Einstein-Podolsky-Rosen steering

    OpenAIRE

    Händchen, V.; Eberle, T.; Steinlechner, S.; Samblowski, A.; Franz, T; Werner, R.; Schnabel, R

    2012-01-01

    The distinctive non-classical features of quantum physics were first discussed in the seminal paper by A. Einstein, B. Podolsky and N. Rosen (EPR) in 1935. In his immediate response E. Schr\\"odinger introduced the notion of entanglement, now seen as the essential resource in quantum information as well as in quantum metrology. Furthermore he showed that at the core of the EPR argument is a phenomenon which he called steering. In contrast to entanglement and violations of Bell's inequalities, ...

  16. Noise-resilient quantum evolution steered by dynamical decoupling

    OpenAIRE

    Liu, Gang-Qin; Po, Hoi Chun; Du, Jiangfeng; Liu, Ren-Bao; Pan, Xin-Yu

    2013-01-01

    Realistic quantum computing is subject to noise. Therefore, an important frontier in quantum computing is to implement noise-resilient quantum control over qubits. At the same time, dynamical decoupling can protect the coherence of qubits. Here we demonstrate non-trivial quantum evolution steered by dynamical decoupling control, which simultaneously suppresses noise effects. We design and implement a self-protected controlled-NOT gate on the electron spin of a nitrogen-vacancy centre and a ne...

  17. Ion beam steering with a high intensity electron beam

    International Nuclear Information System (INIS)

    In conventional theory, steering or bending an ion beam of high energy and high current requires very intense magnetic fields, which are both uneconomical and bulky. This problem is even more severe for a singly charged ion beam with very high atomic number, which requires large magnetic field energy both to bend and also to focus the beam against its self electric field. In this paper we present a new and simple technique, which will substantially alleviate these problems

  18. Dynamic Terahertz Beam Steering Based on Graphene Metasurfaces

    OpenAIRE

    Liu, Liming; Zarate, Yair; Hattori, Haroldo T.

    2015-01-01

    A full (2$\\pi$) phase modulation is critical for efficient wavefront manipulation. In this article, a metasurface based on graphene long/short-strip resonators is used to implement a dynamic 2$\\pi$ phase modulation by applying different voltages to different graphene resonators. The configuration is found to have high reflection efficiency (minimum 56%) and has a full phase modulation in a wide frequency range. Terahertz (THz) beam steering as large as 120 degrees ($\\pm60^\\circ$) is demonstra...

  19. An advanced beam steering system for the SRS at Daresbury

    International Nuclear Information System (INIS)

    The Daresbury SRS is a 2 GeV electron storage ring dedicated to providing synchrotron radiation to approximately 32 stations on 10 beamlines. The storage ring beam steering systems are being replaced to allow automatic real time correction of the electron beam position. The stability problem and the proposed solutions are briefly summarized. Progress on development of the constituent systems is reviewed and some data from early performance trials is presented. (author) 7 refs.; 7 figs

  20. Optimum steering of photon beam lines in SPEAR

    International Nuclear Information System (INIS)

    A common operational requirement for many synchrotron light sources is to maintain steered photon beamlines with minimum corrector strength values. To solve this problem for SPEAR, the authors employed the Singular Value Decomposition (SVD) matrix-inversion technique to minimize corrector strengths while constraining the photon beamlines to remain on target. The result was a reduction in corrector strengths, yielding increased overhead for the photon-beam position feedback systems

  1. Steering and guiding light with light in a nanosuspension

    OpenAIRE

    Terborg, Roland A.; Pérez Torres, Juan; Volke-Sepulveda, Karen

    2013-01-01

    We experimentally demonstrate guiding of a low-power probe beam (633 nm wavelength) by means of a light- induced waveguide generated by the self-focusing of a strong pump beam (532 nm wavelength) in an artificial nonlinear medium, constituted by a colloidal suspension of dielectric nanoparticles. We also demonstrate optical steering of the probe beam by controlling the direction of propagation of the pump beam. The distance over which guiding is demonstrated (5 mm) is remarkably l...

  2. Superdirective dielectric nanoantennas with effect of light steering

    OpenAIRE

    Krasnok, Alexander; Filonov, Dmitry; Slobozhanyuk, Alexey; Simovski, Constantin; Belov, Pavel; Kivshar, Yuri,

    2013-01-01

    We introduce a novel concept of superdirective antennas based on the generation of higher-order optically-induced magnetic multipole modes. All-dielectric nanoantenna can be realized as an optically small spherical dielectric nanoparticle with a notch excited by a point source (e.g. a quantum dot) located in the notch. The superdirectivity effect is not associated with high dissipative losses. For these dielectric nanoantennas we predict the effect of the beam steering at the nanoscale charac...

  3. Self-Steering Antenna Arrays for Distributed Picosatellite Networks

    OpenAIRE

    Murakami, Blaine; Ohta, Aaron; Tamamoto, Michael; Shiroma, Grant; Miyamoto, Ryan; Shiroma, Wayne

    2003-01-01

    The potential for using self-steering arrays for secure crosslinks in picosatellite networks is investigated. The principle of operation and methods of characterization of these so-called retrodirective arrays is reviewed, and examples developed by our group are presented. New challenges for the space environment are identified, specifically the development of two-dimensional, circularly polarized retrodirective arrays optimized for size and power consumption.

  4. Detecting the existence of an invisibility cloak using temporal steering.

    Science.gov (United States)

    Chen, Shin-Liang; Chao, Ching-Shiang; Chen, Yueh-Nan

    2015-01-01

    An invisibility cloak provides a way to hide an object under the detection of waves. A good cloak guides the incident waves through the cloaking shell with few distortion. Even if one day a nearly perfect cloak is built, some important quantum effects, such as dephasing of the electron spin or photon polarization, may still remain. In this work, we consider the possibility that using the temporal steering of these degrees of freedom to detect the existence of an invisibility cloak. PMID:26493048

  5. Detecting the existence of an invisibility cloak using temporal steering

    OpenAIRE

    Shin-Liang Chen; Ching-Shiang Chao; Yueh-Nan Chen

    2015-01-01

    An invisibility cloak provides a way to hide an object under the detection of waves. A good cloak guides the incident waves through the cloaking shell with few distortion. Even if one day a nearly perfect cloak is built, some important quantum effects, such as dephasing of the electron spin or photon polarization, may still remain. In this work, we consider the possibility that using the temporal steering of these degrees of freedom to detect the existence of an invisibility cloak.

  6. Greenhouse gas and alcohol emissions from feedlot steers and calves.

    Science.gov (United States)

    Stackhouse, Kimberly R; Pan, Yuee; Zhao, Yongjing; Mitloehner, Frank M

    2011-01-01

    Livestock's contributions to climate change and smog-forming emissions are a growing public policy concern. This study quantifies greenhouse gas (GHG) and alcohol emissions from calves and feedlot steers. Carbon dioxide (CO) methane (CH), nitrous oxide (NO), ethanol (EtOH), and methanol (MeOH) were measured from a total of 45 Holstein and Angus steers and 9 Holstein calves representative of four different growth stages commonly present on calf ranches and commercial feedlots. Individuals from each animal type were randomly assigned to three equal replicate groups of nine animals per group. Steers were fed a high concentrate diet and calves a milk replacer and grain supplement. Cattle and calves were housed in groups of three animals in an environmental chamber for 24 h. The CO, NO, EtOH, and MeOH concentrations from the air inlet and outlet of the chamber were measured using an INNOVA 1412 monitor and CH using a TEI 55C methane analyzer. Emission rates (g head h) were calculated. The GHGs were mainly produced by enteric fermentation and respiration and differed across life stages of cattle. Compared with dairy cows, feedlot steers produce relatively less GHG. In general, ethanol and methanol, the most important volatile organic compound (VOC) group in the dairy sector, were below the lower limit of detection of the gas analyzer. The present data will be useful to verify models and to enhance GHG emission inventories for enteric fermentation, respiration, and fresh excreta for numerous cattle life stages across the beef industry. PMID:21546675

  7. MODELING OF VEHICULAR STEERING EFFICIENCY IN TRAFFIC DIRECTION MOTION CHANNEL

    Directory of Open Access Journals (Sweden)

    V. A. Ganai

    2011-01-01

    Full Text Available The paper formulates and solves an actual problem pertaining to vehicular steering efficiency in traffic direction motion channel. Models of operator-drivers with low, medium and high rates in motivational perception of road conditions and also a model for controlling a traffic direction motion have been taken into ccount in the paper.  Modeling has been done by using MATLAB.

  8. Workshop on automated beam steering and shaping (ABS). Proceedings

    International Nuclear Information System (INIS)

    A workshop on Automated Beam Steering and Shaping (ABS) was held at CERN in December 1998. This was the first workshop dedicated to this subject. The workshop had two major goals: to review the present status of ABS algorithms and systems around the world and to create a worldwide ABS community. These proceedings contain summary reports from all sessions, contributions from several presentations held at the workshop, and a complete set of abstracts for all presentations. (orig.)

  9. Performance of finishing steers fed different sources of carbohydrates

    Directory of Open Access Journals (Sweden)

    Leandro da Silva Freitas

    2013-05-01

    Full Text Available The objective of this study was to evaluate the effect of carbohydrate sources (corn, soybean hulls or wheat bran in the diet on performance of feedlot steers in the finishing phase. Twenty-four Charolais × Nellore crossbred steers, aged 22 months and initial weight of 335.0±10.9 kg were used in the experiment. Diets contained 40% sorghum silage and 60% concentrate. The intakes of dry matter (DM; 10.68, 10.16 and 10.34 kg/day and crude protein (1.66, 1.70 and 1.72 kg/day were not affected by diets with corn, soybean hulls or wheat bran, respectively. The intakes of neutral and acid detergent fiber were higher for soybean hulls, but the diet containing corn provided higher intake of non-fibrous carbohydrates, total digestible nutrients and digestible energy. Weight gain was higher and better feed conversion for animals fed corn (1.57 kg/day, 6.85 kg DM/kg gain or soybean hulls (1.58 kg/day and 6.61 kg DM/kg gain compared with steers receiving wheat bran (1.29 kg/day and 8.14 kg DM/kg gain in the diet. There was no significant effect of carbohydrate sources on the final body score (3.78 points, energy conversion (28.25 Mcal digestible energy/kg gain, hot carcass yield (57.63 kg/100 kg BW and fat thickness (3.1 mm. From an economic point of view, soybean hulls can be an alternative source of carbohydrate to corn in diets of finishing steers with 60% concentrate.

  10. Microhole Smart Steering and Logging While Drilling System

    Energy Technology Data Exchange (ETDEWEB)

    John Macpherson; Mathias Moeller; Thomas Gregg; Roland Chemali

    2006-06-30

    A background to Coiled Tubing Bottom Hole Assemblies (CT-BHA) is given, and the development of a resistivity measurement component, and a rib-steering motor component, is described. The successful operation of these components in both the laboratory and field environment is described. The primary conclusion of this development is that both components operate as anticipated within the CT-BHA, and significantly extend the possibility of drilling with coiled tubing in the microhole environment.

  11. Imperfection insensitivity analyses of advanced composite tow-steered shells

    OpenAIRE

    Wu, Kin C; Farrokh, Babak; Stanford, Bret K.; Weaver, Paul M

    2016-01-01

    Two advanced composite tow-steered shells, one with tow overlaps and another without overlaps, were previously designed, fabricated and tested in end compression, both without cutouts, and with small and large cutouts. In each case, good agreement was observed between experimental buckling loads and supporting linear bifurcation buckling analyses. However, previous buckling tests and analyses have shown historically poor correlation, perhaps due to the presence of geometric imperfections that...

  12. PERFORMANCE ANALYSIS OF AZIMUTH ELECTRONIC BEAM STEERING MODE SPACEBORNE SAR

    Institute of Scientific and Technical Information of China (English)

    Han Xiaodong; Xu Wei; Han Xiaolei

    2013-01-01

    Pointing angle and pattern of the antenna can be changed swiftly to actualize the azimuth beam scanning by using electronic beam steering,which makes the Synthetic Aperture Radar (SAR)system more flexible and achieve a high resolution or cover a long strip within short time span.When the pointing angle is steered away from boresight,some aberrations may appear on the antenna pattern,e.g.,the grating lobe appears,the main lobe gain decrease,and antenna pattern broadens,e.g.,the aberrations result in the worsening of system performance,and complicate the corresponding performance analysis method.Conventional computation methods of performance parameters do not account for the rapid change of the antenna pattern.It introduces remarkable errors when the scanning angle is large.In this paper,a method of calculating performance parameters is proposed for the beam steering mode,which achieves the parameters by the energy accumulation in time domain.Actually,the proposed method simulates the working process of SAR and obtains accurate performance parameters.Furthermore,we analyze the effects of the grating lobe on the Azimuth Ambiguity to Signal Ratio (AASR),and present the generic Pulse Repetition Frequency (PRF) choosing principle which can also prevent the ambiguous area from weighting by the grating lobe.Finally,the effect of the antenna configuration on the performance parameters is analyzed by a system example.

  13. Imperfection Insensitivity Analyses of Advanced Composite Tow-Steered Shells

    Science.gov (United States)

    Wu, K. Chauncey; Farrokh, Babak; Stanford, Bret K.; Weaver, Paul M.

    2016-01-01

    Two advanced composite tow-steered shells, one with tow overlaps and another without overlaps, were previously designed, fabricated and tested in end compression, both without cutouts, and with small and large cutouts. In each case, good agreement was observed between experimental buckling loads and supporting linear bifurcation buckling analyses. However, previous buckling tests and analyses have shown historically poor correlation, perhaps due to the presence of geometric imperfections that serve as failure initiators. For the tow-steered shells, their circumferential variation in axial stiffness may have suppressed this sensitivity to imperfections, leading to the agreement noted between tests and analyses. To investigate this further, a numerical investigation was performed in this study using geometric imperfections measured from both shells. Finite element models of both shells were analyzed first without, and then, with measured imperfections that were then, superposed in different orientations around the shell longitudinal axis. Small variations in both the axial prebuckling stiffness and global buckling load were observed for the range of imperfections studied here, which suggests that the tow steering, and resulting circumferentially varying axial stiffness, may result in the test-analysis correlation observed for these shells.

  14. Optimization of steering elements in the RIA driver linac

    International Nuclear Information System (INIS)

    The driver linac of the projected RIA facility is a versatile accelerator, a 1.4-GV, CW superconducting (SC) linac designed to simultaneously accelerate several heavy-ion charge states, providing beams from proton to uranium at 400 MeV/u at power levels at a minimum of 100 kW and up to 400 kW for most beams. Acceleration of multiple-charge-state uranium beams places stringent requirements on the linac design. A steering algorithm was derived that fulfilled the driver's real estate requirements, such as placement of steering dipole coils on SC solenoids and of beam position monitors outside cryostats, and beam-dynamics requirements, such as coupling effects induced by the focusing solenoids. The algorithm has been fully integrated into the tracking code TRACK and it is used to study and optimize the number and position of steering elements that minimize the multiple-beam centroid oscillations and preserve the beam emittance under misalignments of accelerating and transverse focusing elements in the driver linac

  15. Cecum microbial communities from steers differing in feed efficiency.

    Science.gov (United States)

    Myer, P R; Wells, J E; Smith, T P L; Kuehn, L A; Freetly, H C

    2015-11-01

    Apart from the rumen, limited knowledge exists regarding the structure and function of bacterial communities within the gastrointestinal tract and their association with beef cattle feed efficiency. The objective of this study was to characterize the microbial communities of the cecum among steers differing in feed efficiency. Within 2 contemporary groups of steers, individual feed intake and BW gain were determined from animals fed the same diet. Within both of 2 contemporary groups, BW was regressed on feed intake and 4 steers within each Cartesian quadrant were sampled ( = 16/group). Bacterial 16S rRNA gene amplicons were sequenced from the cecal content using next-generation sequencing technology. No significant changes in diversity or richness were detected among quadrants, and UniFrac principal coordinate analysis did not show any differences among quadrants for microbial communities within the cecum. The relative abundances of microbial populations and operational taxonomic units revealed significant differences among feed efficiency groups ( Ruminococcaceae, Lachnospiraceae, and Clostridiaceae, with significant shifts in the relative abundance of taxa among feed efficiency groups, including families Ruminococcaceae ( = 0.040), Lachnospiraceae ( = 0.020), Erysipelotrichaceae ( = 0.046), and Clostridiaceae ( = 0.043) and genera ( = 0.049), ( = 0.044), ( = 0.042), ( = 0.040), ( = 0.042), and ( = 0.042). The study identified cecal microbial associations with feed efficiency, ADG, and ADFI. This study suggests an association of the cecum microbial community with bovine feed efficiency at the 16S level. PMID:26641052

  16. Hybrid silicon free-space source with integrated beam steering

    Science.gov (United States)

    Doylend, J. K.; Heck, M. J. R.; Bovington, J. T.; Peters, J. D.; Davenport, M. L.; Coldren, L. A.; Bowers, J. E.

    2013-02-01

    Free-space beam steering using optical phase arrays are desirable as a means of implementing Light Detection and Ranging (LIDAR) and free-space communication links without the need for moving parts, thus alleviating vulnerabilities due to vibrations and inertial forces. Implementing such an approach in silicon photonic integrated circuits is particularly desirable in order to take advantage of established CMOS processing techniques while reducing both device size and packaging complexity. In this work we demonstrate a free-space diode laser together with beam steering implemented on-chip in a silicon photonic circuit. A waveguide phased array, surface gratings, a hybrid III-V/silicon laser and an array of hybrid III/V silicon amplifiers were fabricated on-chip in order to achieve a fully integrated steerable free-space optical source with no external optical inputs, thus eliminating the need for fiber coupling altogether. The chip was fabricated using a modified version of the hybrid silicon process developed at UCSB, with modifications in order to incorporate diodes within the waveguide layer as well as within the III-V gain layer. Beam steering across a 12° field of view with +/-0.3° accuracy and 1.8°x0.6° beam width was achieved, with background peaks suppressed 7 dB relative to the main lobe within the field of view for arbitrarily chosen beam directions.

  17. Entanglement, Einstein-Podolsky-Rosen correlations, Bell nonlocality, and steering

    International Nuclear Information System (INIS)

    In a recent work [Phys. Rev. Lett. 98, 140402 (2007)] we defined 'steering', a type of quantum nonlocality that is logically distinct from both nonseparability and Bell nonlocality. In the bipartite setting, it hinges on the question of whether Alice can affect Bob's state at a distance through her choice of measurement. More precisely and operationally, it hinges on the question of whether Alice, with classical communication, can convince Bob that they share an entangled state under the circumstances that Bob trusts nothing that Alice says. We argue that if she can, then this demonstrates the nonlocal effect first identified in the famous Einstein-Podolsky-Rosen paper [Phys. Rev. 47, 777 (1935)] as a universal effect for pure entangled states. This ability of Alice to remotely prepare Bob's state was subsequently called steering by Schroedinger, whose terminology we adopt. The phenomenon of steering has been largely overlooked, and prior to our work had not even been given a rigorous definition that is applicable to mixed states as well as pure states. Armed with our rigorous definition, we proved that steerable states are a strict subset of the entangled states, and a strict superset of the states that can exhibit Bell nonlocality. In this work we expand on these results and provide further examples of steerable states. We also elaborate on the connection with the original EPR paradox

  18. Redox-active cerium oxide nanoparticles protect human dermal fibroblasts from PQ-induced damage

    OpenAIRE

    Claudia von Montfort; Lirija Alili; Sarah Teuber-Hanselmann; Peter Brenneisen

    2014-01-01

    Recently, it has been published that cerium (Ce) oxide nanoparticles (CNP; nanoceria) are able to downregulate tumor invasion in cancer cell lines. Redox-active CNP exhibit both selective pro-oxidative and antioxidative properties, the first being responsible for impairment of tumor growth and invasion. A non-toxic and even protective effect of CNP in human dermal fibroblasts (HDF) has already been observed. However, the effect on important parameters such as cell death, proliferation and red...

  19. Protein redox chemistry: post-translational cysteine modifications that regulate signal transduction and drug pharmacology

    OpenAIRE

    Wani, Revati; Nagata, Asako; Murray, Brion W.

    2014-01-01

    The perception of reactive oxygen species has evolved over the past decade from agents of cellular damage to secondary messengers which modify signaling proteins in physiology and the disease state (e.g., cancer). New protein targets of specific oxidation are rapidly being identified. One emerging class of redox modification occurs to the thiol side chain of cysteine residues which can produce multiple chemically distinct alterations to the protein (e.g., sulfenic/sulfinic/sulfonic acid, disu...

  20. The enzyme-amplified amperometric DNA sensor using an electrodeposited polymer redox mediator

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    A highly sensitive method for the detection of a breast cancer-associated BRCA-1 gene is reported. The detection is based on a classical sandwich-type assay using horseradish peroxidase (HRP) as a catalytic label and electrodeposited Os2+/3+ conducting polymer (PAA-PVI-Os) as a redox mediator. Target DNA could be detected by the HRP-catalyzed reduction of H2O2, leading to a limit of detection as low as 10 fM.

  1. Postweaning performance and carcass merit of F1 steers sired by Brahman and alternative subtropically adapted breeds.

    Science.gov (United States)

    Franke, D E

    1997-10-01

    Comparisons were made among F1 steers sired by Brahman and alternative subtropically adapted breeds of bulls for feedlot and carcass traits when steers were produced from Angus- and Hereford-type dams. Brahman-derivative breeds included Brangus, Beefmaster, and Santa Gertrudis. Brangus- and Beefmaster-sired steers weighed less at slaughter, whereas carcasses of Brangus- and Santa Gertrudis-sired steers had more marbling than those of Brahman-sired steers. Brahman-sired steer carcasses had greater longissimus muscle area than carcasses of Santa Gertrudis-sired steers. Other Zebu breeds compared to Brahman were Boran, Gir, Indu-Brazil, Nellore, Red Brahman, and Sahiwal. Steers by Brahman sires had higher slaughter weights than steers by Boran, Gir, Nellore, or Sahiwal sires. Hot carcass weights of Brahman-sired steers were also higher than those of Boran- and Sahiwal-sired steers. Steer carcasses by Brahman sires had greater longissimus muscle area than those of steers by Sahiwal sires. Non-Zebu breeds included Tuli and Senepol. Steers by Tuli sires grew slower, had lower slaughter weights, and their carcasses weighed less than those of Brahman-sired steers. Brahman-sired steer carcasses had greater longissimus muscle area but less marbling than carcasses of Tuli-sired steers. These data suggest that steers by Brahman sires have an advantage for slaughter weight over steers by Brangus, Beefmaster, Boran, Gir, Nellore, Sahiwal, and Tuli sires, but their carcasses are at a disadvantage for marbling score compared with those by Brangus, Boran, Nellore, and Tuli sires. PMID:9331861

  2. Carbon Redox-Polymer-Gel Hybrid Supercapacitors

    Science.gov (United States)

    Vlad, A.; Singh, N.; Melinte, S.; Gohy, J.-F.; Ajayan, P. M.

    2016-02-01

    Energy storage devices that provide high specific power without compromising on specific energy are highly desirable for many electric-powered applications. Here, we demonstrate that polymer organic radical gel materials support fast bulk-redox charge storage, commensurate to surface double layer ion exchange at carbon electrodes. When integrated with a carbon-based electrical double layer capacitor, nearly ideal electrode properties such as high electrical and ionic conductivity, fast bulk redox and surface charge storage as well as excellent cycling stability are attained. Such hybrid carbon redox-polymer-gel electrodes support unprecedented discharge rate of 1,000C with 50% of the nominal capacity delivered in less than 2 seconds. Devices made with such electrodes hold the potential for battery-scale energy storage while attaining supercapacitor-like power performances.

  3. Physicochemical and redox characteristics of particulate matter (PM) emitted from gasoline and diesel passenger cars

    Science.gov (United States)

    Geller, Michael D.; Ntziachristos, Leonidas; Mamakos, Athanasios; Samaras, Zissis; Schmitz, Debra A.; Froines, John R.; Sioutas, Constantinos

    Particulate matter (PM) originating from mobile sources has been linked to a myriad of adverse health outcomes, ranging from cancer to cardiopulmonary disease, and an array of environmental problems, including global warming and acid rain. Till date, however, it is not clear which physical characteristics or chemical constituents of PM are significant contributors to the magnitude of the health risk. This study sought to determine the relationship between physical and chemical characteristics of PM while quantitatively measuring samples for redox activity of diesel and gasoline particulate emissions from passenger vehicles typically in use in Europe. The main objective was to relate PM chemistry to the redox activity in relation to vehicle type and driving cycle. Our results showed a high degree of correlation between several PM species, including elemental and organic carbon, low molecular weight polycyclic aromatic hydrocarbons, and trace metals such as lithium, beryllium, nickel and zinc, and the redox activity of PM, as measured by a quantitative chemical assay, the dithiothreitol (DTT) assay. The reduction in PM mass or number emission factors resulting from the various engine configurations, fuel types and/or after-treatment technologies, however, was non-linearly related to the decrease in overall PM redox activity. While the PM mass emission rate from the diesel particle filter (DPF)-equipped vehicle was on average approximately 25 times lower than that of the conventional diesel, the redox potential was only eight times lower, which makes the per mass PM redox potential of the DPF vehicle about three times higher. Thus, a strategy aimed at protecting public health and welfare by reducing total vehicle mass and number emissions may not fully achieve the desired goal of preventing the health consequences of PM exposure. Further, study of the chemical composition and interactions between various chemical species may yield greater insights into the toxicity of

  4. Thiol Redox Sensitivity of Two Key Enzymes of Heme Biosynthesis and Pentose Phosphate Pathways: Uroporphyrinogen Decarboxylase and Transketolase

    Directory of Open Access Journals (Sweden)

    Brian McDonagh

    2013-01-01

    Full Text Available Uroporphyrinogen decarboxylase (Hem12p and transketolase (Tkl1p are key mediators of two critical processes within the cell, heme biosynthesis, and the nonoxidative part of the pentose phosphate pathway (PPP. The redox properties of both Hem12p and Tkl1p from Saccharomyces cerevisiae were investigated using proteomic techniques (SRM and label-free quantification and biochemical assays in cell extracts and in vitro with recombinant proteins. The in vivo analysis revealed an increase in oxidized Cys-peptides in the absence of Grx2p, and also after treatment with H2O2 in the case of Tkl1p, without corresponding changes in total protein, demonstrating a true redox response. Out of three detectable Cys residues in Hem12p, only the conserved residue Cys52 could be modified by glutathione and efficiently deglutathionylated by Grx2p, suggesting a possible redox control mechanism for heme biosynthesis. On the other hand, Tkl1p activity was sensitive to thiol redox modification and although Cys622 could be glutathionylated to a limited extent, it was not a natural substrate of Grx2p. The human orthologues of both enzymes have been involved in certain cancers and possess Cys residues equivalent to those identified as redox sensitive in yeast. The possible implication for redox regulation in the context of tumour progression is put forward.

  5. An investigation on motor-driven power steering-based crosswind disturbance compensation for the reduction of driver steering effort

    Science.gov (United States)

    Kim, Kyuwon; Kim, Boemjun; Go, Youngil; Park, Jaeyong; Park, Joonhong; Suh, Insoo; Yi, Kyongsu

    2014-07-01

    This paper describes a lateral disturbance compensation algorithm for an application to a motor-driven power steering (MDPS)-based driver assistant system. The lateral disturbance including wind force and lateral load transfer by bank angle reduces the driver's steering refinement and at the same time increases the possibility of an accident. A lateral disturbance compensation algorithm is designed to determine the motor overlay torque of an MDPS system for reducing the manoeuvreing effort of a human driver under lateral disturbance. Motor overlay torque for the compensation of driver's steering torque induced by the lateral disturbance consists of human torque feedback and feedforward torque. Vehicle-driver system dynamics have been investigated using a combined dynamic model which consists of a vehicle dynamic model, driver steering dynamic model and lateral disturbance model. The human torque feedback input has been designed via the investigation of the vehicle-driver system dynamics. Feedforward input torque is calculated to compensate additional tyre self-aligning torque from an estimated lateral disturbance. The proposed compensation algorithm has been implemented on a developed driver model which represents the driver's manoeuvreing characteristics under the lateral disturbance. The developed driver model has been validated with test data via a driving simulator in a crosswind condition. Human-in-the-loop simulations with a full-scale driving simulator on a virtual test track have been conducted to investigate the real-time performance of the proposed lateral disturbance compensation algorithm. It has been shown from simulation studies and human-in-the-loop simulation results that the driver's manoeuvreing effort and a lateral deviation of the vehicle under the lateral disturbance can be significantly reduced via the lateral disturbance compensation algorithm.

  6. Data transfer through beam steering using agile lensing

    Science.gov (United States)

    Arshad, Muhammad Assad; Reza, Syed Azer; Muhammad, Ahsan

    2016-04-01

    This paper presents a data transfer scheme using multi-focus tunable lenses. The design involves the use of a standard laser source and a variable focus agile lens to steer to the laser beam that passes through the lens. In our proposed system, the beam steer angle depends on an input electrical signal which drives the tunable lens. Therefore the beam steer angle is made to follow the variations in the input electrical drive signal. This is extremely interesting for data transfer applications as the data signal can be used as the input drive signal to the lens. The laser beam is steered according to the input data voltage levels and when the beam is incident on a photo-detector of a finite size, only a fraction of its total incident optical power is received by the photo-detector. This power contribution is proportional to the fraction of the total number of photons per unit area which are incident on the active area of the detector. The remaining photons which are not incident on the photo-detector do not contribute to the received power at the photo-detector. We present the theory of beam steering through a tunable lens and present a theoretical framework which governs data transfer through the proposed method. We also present the transfer function of the proposed system which helps us to calculate its essential theoretical performance parameters such as modulation depth and bit error rates. We also present experimental results to demonstrate efficient data transfer through the proposed method. As tunable lenses are primarily deployed in motion-free multi-focus cameras hence most of the modern portable devices such as cellphones and tablets use these lenses to operate the in-built variable focus cameras that are part of these devices. Because tunable lenses are commonly present in several different portable devices, the proposed method of data transfer between two devices is highly promising as it expands the use of the already deployed tunable lenses with

  7. Quantification of Einstein-Podolski-Rosen steering for two-qubit states

    Science.gov (United States)

    Costa, A. C. S.; Angelo, R. M.

    2016-02-01

    In the last few years, several criteria to identify Einstein-Podolski-Rosen steering have been proposed and experimentally implemented. On the operational side, however, the evaluation of the steerability degree of a given state has shown to be a difficult task and only a few results are known. In this work, we propose a measure of steering that is based on the maximal violation of well-established steering inequalities. Applying this approach to two-qubit states, we managed to derive simple closed formulas for steering in the two- and three-measurement scenarios. We also provide closed formulas for quantifiers of Bell nonlocality in the respective scenarios. Finally, we show that our measures of steering verify the entanglement-steering-nonlocality hierarchy and reproduce results reported so far.

  8. Objectification of steering feel around straight-line driving for vehicle/tyre design

    Science.gov (United States)

    Kim, Jungsik; Yoon, Yong-San

    2015-02-01

    This paper presents the objectification techniques for the assessment of steering feel including {on-centre} feel and steering response by measurement data. Here, new objective parameters are developed by considering not only the process by which the steering feel is evaluated subjectively but also by the ergonomic perceptive sensitivity of the driver. In order to validate such objective parameters, subjective tests are carried out by professional drivers. Objective measurements are also performed for several cars at a proving ground. The linear correlation coefficients between the subjective ratings and the objective parameters are calculated. As one of new objective parameters, steering wheel angle defined by ergonomic perception sensitivity shows high correlation with the subjective questionnaires of on-center responses. Newly defined steering torque curvature also shows high correlation with the subjective questionnaires of on-center effort. These correlation results conclude that the subjective assessment of steering feel can be successfully explained and objectified by means of the suggested objective parameters.

  9. Main group redox catalysis: reversible P(III)/P(V) redox cycling at a phosphorus platform.

    Science.gov (United States)

    Dunn, Nicole L; Ha, Minji; Radosevich, Alexander T

    2012-07-18

    A planar, trivalent phosphorus compound is shown to undergo reversible two-electron redox cycling (P(III)/P(V)) enabling its use as catalyst for a transfer hydrogenation reaction. The trivalent phosphorus compound activates ammonia-borane to furnish a 10-P-5 dihydridophosphorane, which in turn is shown to transfer hydrogen cleanly to azobenzene, yielding diphenylhydrazine and regenerating the initial trivalent phosphorus species. This result constitutes a rare example of two-electron redox catalysis at a main group compound and suggests broader potential for this nonmetal platform to support bond-modifying redox catalysis of the type dominated by transition metal catalysts. PMID:22746974

  10. A Vehicle Haptic Steering by Wire System Based on High Gain GPI Observers

    OpenAIRE

    A. Rodriguez-Angeles; H. Sira-Ramirez; J. A. Garcia-Antonio

    2014-01-01

    A vehicle steering by wire (SBW) haptic system based on high gain generalized proportional integral (GPI) observers is introduced. The observers are considered for the estimation of dynamic perturbations that are present at the tire and steering wheel. To ensure efficient tracking between the commanded steering wheel angle and the tire orientation angle, the estimated perturbations are on line canceled. As to provide a haptic interface with the driver, the estimated dynamic effects at the st...

  11. Evaluation of Fatigue Life Reliability of Steering Knuckle Using Pearson Parametric Distribution Model

    OpenAIRE

    Nik Abdullah, N. M.; Shahrum, A.; Dzuraidah, A. W.; Asri, Y. M.; Azrulhisham, E. A.; Che Hassan, C. H.

    2010-01-01

    Steering module is a part of automotive suspension system which provides a means for an accurate vehicle placement and stability control. Components such as steering knuckle are subjected to fatigue failures due to cyclic loads arising from various driving conditions. This paper intends to give a description of a method used in the fatigue life reliability evaluation of the knuckle used in a passenger car steering system. An accurate representation of Belgian pave service loads in terms of re...

  12. Deformation effect simulation and optimization for double front axle steering mechanism

    Science.gov (United States)

    Wu, Jungang; Zhang, Siqin; Yang, Qinglong

    2013-03-01

    This paper research on tire wear problem of heavy vehicles with Double Front Axle Steering Mechanism from the flexible effect of Steering Mechanism, and proposes a structural optimization method which use both traditional static structural theory and dynamic structure theory - Equivalent Static Load (ESL) method to optimize key parts. The good simulated and test results show this method has high engineering practice and reference value for tire wear problem of Double Front Axle Steering Mechanism design.

  13. Modeling, Validation, and Control of Electronically Actuated Pitman Arm Steering for Armored Vehicle

    Directory of Open Access Journals (Sweden)

    Vimal Rau Aparow

    2016-01-01

    Full Text Available In this study, 2 DOF mathematical models of Pitman arm steering system are derived using Newton’s law of motion and modeled in MATLAB/SIMULINK software. The developed steering model is included with a DC motor model which is directly attached to the steering column. The Pitman arm steering model is then validated with actual Pitman arm steering test rig using various lateral inputs such as double lane change, step steer, and slalom test. Meanwhile, a position tracking control method has been used in order to evaluate the effectiveness of the validated model to be implemented in active safety system of a heavy vehicle. The similar method has been used to test the actual Pitman arm steering mechanism using hardware-in-the-loop simulation (HILS technique. Additional friction compensation is added in the HILS technique in order to minimize the frictional effects that occur in the mechanical configuration of the DC motor and Pitman arm steering. The performance of the electronically actuated Pitman arm steering system can be used to develop a firing-on-the-move actuator (FOMA for an armored vehicle. The FOMA can be used as an active safety system to reject unwanted yaw motion due to the firing force.

  14. Cycling around a curve: the effect of cycling speed on steering and gaze behavior.

    Directory of Open Access Journals (Sweden)

    Pieter Vansteenkiste

    Full Text Available Although it is generally accepted that visual information guides steering, it is still unclear whether a curvature matching strategy or a 'look where you are going' strategy is used while steering through a curved road. The current experiment investigated to what extent the existing models for curve driving also apply to cycling around a curve, and tested the influence of cycling speed on steering and gaze behavior. Twenty-five participants were asked to cycle through a semicircular lane three consecutive times at three different speeds while staying in the center of the lane. The observed steering behavior suggests that an anticipatory steering strategy was used at curve entrance and a compensatory strategy was used to steer through the actual bend of the curve. A shift of gaze from the center to the inside edge of the lane indicates that at low cycling speed, the 'look where you are going' strategy was preferred, while at higher cycling speeds participants seemed to prefer the curvature matching strategy. Authors suggest that visual information from both steering strategies contributes to the steering system and can be used in a flexible way. Based on a familiarization effect, it can be assumed that steering is not only guided by vision but that a short-term learning component should also be taken into account.

  15. Performance Analysis of the Different Null Steering Techniques in the Field of Adaptive Beamforming

    Directory of Open Access Journals (Sweden)

    Fawad Zaman

    2013-04-01

    Full Text Available In this study, we compare the performance of three null steering techniques using uniform linear array. These techniques include Null Steering without using Phase Shifters, Null Steering by Decoupling the Real Weights and Null Steering by Decoupling the Complex Weights. The evaluation criteria of these techniques is based on the bases of different parameters i.e., null depth, main beam width, side lobe levels, number of steerable nulls, computational complexity and number of sensors used in the array. The validity and effectiveness of these techniques is reflected by the resultant radiation pattern of the array.

  16. Electron Transfer rate between a electrode and a bridged redox

    OpenAIRE

    Cruz, A. V. B.; Mishra, A. K.; Schmickler, W.

    2009-01-01

    We derive an explict bias dependent expression for electron transfer reaction rate from a solvated redox to a electrode through a bridged molecule of arbitrary length. The interaction of the solvated redox with the solvent is modelled as a classical harmonic oscillator bath. The effect of competing process, namely resonance tunneling between redox and bridge and the solvation of the redox is investigated. Plots were produced for the case of 5 atom bridge. Our analysis shows that for certain s...

  17. Redox regulation of mammalian 3-mercaptopyruvate sulfurtransferase.

    Science.gov (United States)

    Nagahara, Noriyuki; Nagano, Masatoshi; Ito, Takaaki; Suzuki, Hidenori

    2015-01-01

    A cystine-catabolizing enzyme, 3-mercaptopyruvate sulfurtransferase catalyzes the trans-sulfuration reaction of mercaptopyruvate or thiosulfate to thiol-containing compounds or cyanide. During the catalytic process, persulfide is formed at the catalytic site cysteine residue and a sulfur-acceptor substrate donates the outer sulfur of the persulfide to form a new persulfide molecule. Subsequently, the molecule can be reduced by thioredoxin to form hydrogen sulfide. The enzyme is regulated by redox changes via two redox-sensing molecular switches consisting redox-sensitive cysteine residues. One switch is the catalytic cysteine in itself, which is oxidized to form a cysteine-sulfenate resulting in inhibition of catalytic activity. The sulfenate can be reduced by thioredoxin resulting in restoration of the activity. The redox potential of sulfenate is lower than that of glutathione and greater than that of thioredoxin. The other switch involves cysteine residues positioned on the surface of the enzyme. The oxidation the intermolecular disulfide linkage at these cysteine residues, leading to dimer formation, inhibits enzyme activity. On the other hand, reduction-associated monomer formation increases catalytic activity. Thioredoxin reduces the disulfide bond more effectively than dithiothreitol, although the specificity mechanism has not been identified. Congenital defects in this enzyme result in, mercaptolactate-cysteine disulfiduria associated with or without mental retardation. However, the pathogenesis has not been identified. Because 3-mercaptopyruvate sulfurtransferase serves as a cellular antioxidative protein, the other biological functions related to the inhabitant disease are being investigated. PMID:25725525

  18. Energy storage: Redox flow batteries go organic

    Science.gov (United States)

    Wang, Wei; Sprenkle, Vince

    2016-03-01

    The use of renewable resources as providers to the electrical grid is hampered by the intermittent and irregular nature in which they generate energy. Electrical energy storage technology could provide a solution and now, by using an iterative design process, a promising anolyte for use in redox flow batteries has been developed.

  19. Redox Equilibria in SO2 Oxidation Catalysts

    DEFF Research Database (Denmark)

    Rasmussen, Søren Birk; Eriksen, Kim Michael; Boghosian, Soghomon; Fehrmann, Rasmus

    been carried out regarding the complex and compound formation of V(V) and the formation of V(IV) and V(III) compounds with low solubility causing catalyst deactivation. However, the redox chemistry of vanadium and the complex formation of V(IV) is much less investigated and further information on these...

  20. Metathetical Redox Reaction of (Diacetoxyiodoarenes and Iodoarenes

    Directory of Open Access Journals (Sweden)

    Antoine Jobin-Des Lauriers

    2015-12-01

    Full Text Available The oxidation of iodoarenes is central to the field of hypervalent iodine chemistry. It was found that the metathetical redox reaction between (diacetoxyiodoarenes and iodoarenes is possible in the presence of a catalytic amount of Lewis acid. This discovery opens a new strategy to access (diacetoxyiodoarenes. A computational study is provided to rationalize the results observed.

  1. CANCER

    Directory of Open Access Journals (Sweden)

    N. Kavoussi

    1973-09-01

    Full Text Available There are many carcinogenetic elements in industry and it is for this reason that study and research concerning the effect of these materials is carried out on a national and international level. The establishment and growth of cancer are affected by different factors in two main areas:-1 The nature of the human or animal including sex, age, point and method of entry, fat metabolism, place of agglomeration of carcinogenetic material, amount of material absorbed by the body and the immunity of the body.2 The different nature of the carcinogenetic material e.g. physical, chemical quality, degree of solvency in fat and purity of impurity of the element. As the development of cancer is dependent upon so many factors, it is extremely difficult to determine whether a causative element is principle or contributory. Some materials are not carcinogenetic when they are pure but become so when they combine with other elements. All of this creates an industrial health problem in that it is almost impossible to plan an adequate prevention and safety program. The body through its system of immunity protects itself against small amounts of carcinogens but when this amount increases and reaches a certain level the body is not longer able to defend itself. ILO advises an effective protection campaign against cancer based on the Well –equipped laboratories, Well-educated personnel, the establishment of industrial hygiene within factories, the regular control of safety systems, and the implementation of industrial health principles and research programs.

  2. Protein redox chemistry: post-translational cysteine modifications that regulate signal transduction and drug pharmacology

    Directory of Open Access Journals (Sweden)

    Revati eWani

    2014-10-01

    Full Text Available The perception of reactive oxygen species (ROS has evolved over the past decade from agents of cellular damage to secondary messengers which modify signaling proteins in physiology and the disease state (e.g. cancer. New protein targets of specific oxidation are rapidly being identified. One emerging class of redox modification occurs to the thiol side chain of cysteine residues which can produce multiple chemically-distinct alterations to the protein (e.g. sulfenic/sulfinic/sulfonic acid, disulfides. These post-translational modifications (PTM are shown to affect the protein structure and function. Because redox-sensitive proteins can traffic between subcellular compartments that have different redox environments, cysteine oxidation enables a spatio-temporal control to signaling. Understanding ramifications of these oxidative modifications to the functions of signaling proteins is crucial for understanding cellular regulation as well as for informed-drug discovery process. The effects of EGFR oxidation of Cys797 on inhibitor pharmacology are presented to illustrate the principle. Taken together, cysteine redox PTM can impact both cell biology and drug pharmacology.

  3. Are bioassays useful tools to assess redox processes and biodegradation?

    DEFF Research Database (Denmark)

    Albrechtsen, Hans-Jørgen; Pedersen, Philip Grinder; Ludvigsen, L.

    When evaluating potentials for natural attenuation, assessment of ongoing redox processes are important. Terminal electron accepting processes (TEAPs) such as denitrification, Fe(Ill), Mn(IV), and sulphate reduction and methane production have been assessed by several approaches including redox...... aromatic and chlorinated aliphatic compounds in landfill leachate plumes, and of pesticides in aquifers with various redox conditions....

  4. Redox proteomics for the assessment of redox-related posttranslational regulation in plants.

    Science.gov (United States)

    Mock, Hans-Peter; Dietz, Karl-Josef

    2016-08-01

    The methodological developments of in vivo and in vitro protein labeling and subsequent detection enable sensitive and specific detection of redox modifications. Such methods are presently applied to diverse cells and tissues, subproteomes and developmental as well as environmental conditions. The chloroplast proteome is particularly suitable for such kind of studies, because redox regulation of chloroplast proteins is well established, many plastid proteins are abundant, redox network components have been inventoried in great depth, and functional consequences explored. Thus the repertoire of redox-related posttranslational modifications on the one hand side and their abundance on the other pose a challenge for the near future to understand their contribution to physiological regulation. The various posttranslational redox modifications are introduced, followed by a description of the available proteomics methods. The significance of the redox-related posttranslational modification is exemplarily worked out using established examples from photosynthesis. This article is part of a Special Issue entitled: Plant Proteomics - a bridge between fundamental processes and crop production, edited by Dr. Hans-Peter Mock. PMID:26784836

  5. Fatty acid profiles, meat quality, and sensory attributes of organic versus conventional dairy beef steers.

    Science.gov (United States)

    Bjorklund, E A; Heins, B J; Dicostanzo, A; Chester-Jones, H

    2014-03-01

    Meat from Holstein and crossbred organic and conventional dairy steers were evaluated and compared for fatty acid profiles, meat quality, sensory attributes, and consumer acceptance. Bull calves (n=49) were randomly assigned to 1 of 3 replicated groups: conventional (CONV), organic (ORG, pasture + concentrate), or grass-fed organic (GRS) and were born at the University of Minnesota West Central Research and Outreach Center (Morris, MN) between March and May 2011. The CONV steers (n=16) were fed a diet that contained 80% concentrate and 20% forage, and ORG steers (n=16) were fed a diet of organic corn, organic corn silage, and organic protein supplement. Furthermore, ORG steers consumed at least 30% of diet dry matter of high-quality organic pasture during the grazing season. The GRS steers (n=17) consumed 100% forage from pasture during the grazing season and high-quality hay or hay silage during the nongrazing season. The ORG steers had fat that was greater in oleic acid (C18:1) than the GRS and CONV steers (47.1, 36.1, and 39.9%, respectively). The GRS steers (21.9%) were lower for monounsaturated fat than the ORG (42.1%) and CONV (40.4%) steers. Furthermore, the GRS steers tended to have greater n-3 fat and had lower n-6 fat than the ORG and CONV steers. Consequently, the GRS (1.4%) steers had a lower n-6-to-n-3 fat ratio than the ORG (12.9%) and CONV (10.0%) steers. The GRS (2.6 kg) steers had steaks that were not different for Warner-Bratzler shear force than ORG (2.3 kg) steaks; however, the GRS steaks tended to have greater shear force than the CONV (2.0 kg) steaks. The 3 steer group had steaks that were not different for color brightness (L*; 0 = black and 100 = white) and yellowness/blueness (b*; positive values = yellow and negative values = blue) values; however, the GRS (10.5) steaks had lower redness/greenness (a*; positive values = red and negative values = green) values than CONV (14.5) steaks. For sensory attributes (0- to 120-point scale), no

  6. A Study on the Steering Strategy for the Master Clock

    Science.gov (United States)

    Zhao, Shu-Hong; Wang, Zheng-Ming; Yin, Dong-Shan

    2015-01-01

    A physical realization of UTC (Coordinated Universal Time) by the master clock system in a time laboratory is named UTC(k). In order to make the deviation of UTC(k) from UTC as small as possible, and keep high short-term and long-term frequency stabilities as well, a new steering algorithm is proposed, and the detailed algorithm is as follows: Firstly, a stable reference time scale (TA) for real-time monitoring UTC(NTSC) is introduced. The time scale algorithm for generating TA, which is computed as a weighted average of about 22 free-running atomic clocks at the National Time Service Center (NTSC), is based on the ALGOS algorithm. And the weighting procedure is designed to optimize the short-term frequency stability of the scale. Secondly, the frequency offset is calculated. (1) The frequency of the master clock in the next time interval is calculated; (2) The phase difference between TA and UTC(NTSC) is deducted; (3) The final frequency offset is generated on the basis of above steps. A software is compiled according to this algorithm. The results calculated with the software are sent to the microphase stepper automatically, so that the time signal derived from the steered master clock can be accurate, meanwhile its stability is not influenced. Finally, the experimental result shows that the new master clock steering strategy can control the phase offset within ±15 ns, meanwhile it can also improve its short-term stability on the condition that its long-term one is not influenced.

  7. Evaluation of Potential Usage of Incremental-Type Rotary Encoder Application for Angle Sensing in Steering System

    Directory of Open Access Journals (Sweden)

    Sunarto Kaleg

    2014-12-01

    Full Text Available The main target of a steering system is that the driver can change vehicle trajectory in accordance with the desired direction.  Power steering has become a standard feature in automobile.  It provides assisting power when the driver turns the steering wheel. The well-known power steering types include; Hydraulic Power Steering (HPS, Electro - Hydraulic Power Steering (EHPS, and Electric Power Steering (EPS. EHPS or EPS uses an Electronic Control Unit (ECU which is specific for each vehicle. The ECU should be able to regulate power of electric motor to provide corresponding assisting power for the steering wheel. Therefore ECU requires input signals, one of which is vehicle wheel angle that can be indicated from the vehicle steering wheel angle. Incremental type of Rotary Encoder (RE is used in steering angle sensor on a minibus. RE specification used was 60 pulses per rotation and the minibus steering transmission specification is 3.5 round of right wheel off angle to the left wheel off angle. So we get the RE angular resolution 6ºper pulse and 105 number of pulses to half of the steering transmission ratio. Repeatability then tested against to a steering angle counter module. Testing is done with a test cycle consisting of 3 repetitions: condition center of the steering wheel, the steering wheel is turned to full right, then to the full left, then back to the right up to the steering wheel center. The results obtained 2 pulses deviation, or equivalent to 12º of steering angle.

  8. Growth, carcass characteristics, and profitability of organic versus conventional dairy beef steers.

    Science.gov (United States)

    Bjorklund, E A; Heins, B J; Dicostanzo, A; Chester-Jones, H

    2014-03-01

    Bull calves (n=49), born at the University of Minnesota West Central Research and Outreach Center (Morris) between March and May 2011, were used to compare growth measurements and profitability of conventional and organic dairy steers. Calves were assigned to 1 of 3 replicated groups at birth: conventional (CONV; n=16), organic (pasture and concentrate; ORG; n=16), or organic grass only (GRS; n=17), and analysis of variables was on a pen basis. Breed groups of calves were Holstein (HO; n=9); Holsteins (n=11) maintained at 1964 breed average level; crossbreds (n=19) including combinations of HO, Montbéliarde, and Swedish Red; and crossbreds (n=10) including combinations of HO, Jersey, Swedish Red, and Normande. The CONV steers were fed a diet of 80% concentrate and 20% forage. The ORG steers were fed a diet of organic corn, organic corn silage, and at least 30% of their diet consisted of organic pasture during the grazing season. The GRS steers grazed pasture during the grazing season and were fed high-quality hay or hay silage during the nongrazing season. Intakes of a total mixed ration were recorded daily with herd management software. A profit function was defined to include revenues and expenses for beef value, feed intake, pasture intake, health cost, and yardage. The GRS (358.6 kg) steers had lesser total gains from birth to slaughter than ORG (429.6 kg) and CONV (534.5 kg) steers. Furthermore, the GRS (0.61 kg/d) steers had lesser average daily gain from birth compared with ORG (0.81 kg/d) and CONV (1.1 kg/d) steers. The GRS and ORG steers had smaller rib eye area (49.5 and 65.8 cm(2), respectively) compared with CONV (75.4 cm(2)) steers. For profitability, GRS steers had 43% greater profit than CONV steers due to organic beef price premiums and lower feed costs. On the other hand, ORG steers had substantially less profit than CONV steers. The higher cost of production for the ORG steers is due to the extreme high value of organic corn. The results of the

  9. Influence of feed efficiency classification on diet digestibility and growth performance of beef steers.

    Science.gov (United States)

    Russell, J R; Minton, N O; Sexten, W J; Kerley, M S; Hansen, S L

    2016-04-01

    The diet digestibility and feed efficiency (FE) relationship is not well characterized in cattle. The study objective was to determine effects of growing phase FE and diet as well as finishing phase diet on diet digestibility and finishing phase FE. Two groups, totaling 373 crossbred steers, were fed for 70 d at the University of Missouri for the growing phase and then shipped to Iowa State University (ISU) for finishing. GrowSafe feed bunks were used during both the growing and the finishing phases. Steers were fed either growing phase whole shell corn (G-Corn) or growing phase roughage-based (G-Rough) diets. Within each group, the 12 greatest and 12 least feed efficient steers from each growing diet ( = 96 total; 48 steers/group; 488 ± 5 kg) were selected for further evaluation. At ISU, steers were fed an average of 10 g TiO/steer daily in receiving phase diets similar to growing diets for 15 d, with fecal grab samples collected on d 14 and 15 to determine diet DM digestibility during receiving (GDMdig). For finishing, steers were transitioned to byproduct-based diets (F-Byp) or corn-based diets (F-Corn) with 12 steers per growing-finishing diet combination per group. Optaflexx (200 mg/d) was fed for 28 d before harvest, and the TiO protocol was repeated immediately before introducing Optaflexx to determine diet DM digestibility during finishing (FDMdig). Data from the 2 groups (96 steers) were pooled, and steers were ranked by growing phase G:F and then classified as the 24 greatest feed efficient (HFE) or 24 least feed efficient (LFE) steers from each growing diet. Data were analyzed using PROC MIXED of SAS with group applied as a fixed effect. There was a positive correlation between GDMdig and FDMdig for steers fed nutritionally similar diets during both feeding phases, G-Rough/F-Byp steers ( = 0.68, Corn/F-Corn steers ( = 0.49, = 0.02), but a negative correlation for G:F between phases in G-Rough/F-Corn steers ( = -0.57, corn finished, reinforcing the idea

  10. Secure Continuous Variable Teleportation and Einstein-Podolsky-Rosen Steering.

    Science.gov (United States)

    He, Qiongyi; Rosales-Zárate, Laura; Adesso, Gerardo; Reid, Margaret D

    2015-10-30

    We investigate the resources needed for secure teleportation of coherent states. We extend continuous variable teleportation to include quantum teleamplification protocols that allow nonunity classical gains and a preamplification or postattenuation of the coherent state. We show that, for arbitrary Gaussian protocols and a significant class of Gaussian resources, two-way steering is required to achieve a teleportation fidelity beyond the no-cloning threshold. This provides an operational connection between Gaussian steerability and secure teleportation. We present practical recipes suggesting that heralded noiseless preamplification may enable high-fidelity heralded teleportation, using minimally entangled yet steerable resources. PMID:26565449

  11. Adaptive feedback linearization applied to steering of ships

    Directory of Open Access Journals (Sweden)

    Thor I. Fossen

    1993-10-01

    Full Text Available This paper describes the application of feedback linearization to automatic steering of ships. The flexibility of the design procedure allows the autopilot to be optimized for both course-keeping and course-changing manoeuvres. Direct adaptive versions of both the course-keeping and turning controller are derived. The advantages of the adaptive controllers are improved performance and reduced fuel consumption. The application of nonlinear control theory also allows the designer in a systematic manner to compensate for nonlinearities in the control design.

  12. Steering the osteoclast through the demineralization-collagenolysis balance

    DEFF Research Database (Denmark)

    Søe, Kent; Merrild, Ditte Marie Horslev; Delaissé, Jean-Marie

    2013-01-01

    generated when collagen degradation is slower than demineralization, and trenches when collagen degradation is as fast as demineralization. Next we treated the osteoclasts with a low dose of a carbonic anhydrase inhibitor to slightly decrease the rate of demineralization, thereby allowing collagen......, forming a pit, and continues parallel to the bone surface, forming a trench. Importantly, we show that the progress of the osteoclast along this route depends on the balance between the rate of collagenolysis and demineralization. We propose that the osteocytes and bone lining cells surrounding the...... osteoclast may act on this balance to steer the osteoclast resorptive activity in order to give the excavations a specific shape....

  13. Methods of steering and focusing ion and electron beams

    International Nuclear Information System (INIS)

    This patent describes a method for steering or focussing beams such as ion or electron beams with a magnetic field. The method consists of: generating a large electric current in a straight conducting wire; projecting charged particles in proximity with the conducting wire; deflecting the charged particles by generating in proximity with the wire a circular magnetic field; confining each of the charged particles to a path which extends in a direction substantially coplanar with the conducting wire wherein a deflecting force generated by the coaxial magnetic field is exerted on each particle in the plane defined by the conducting wire and the path of the particle

  14. Superdirective dielectric nanoantennas with effect of light steering

    CERN Document Server

    Krasnok, Alexander; Slobozhanyuk, Alexey; Simovski, Constantin; Belov, Pavel; Kivshar, Yuri

    2013-01-01

    We introduce a novel concept of superdirective antennas based on the generation of higher-order optically-induced magnetic multipole modes. All-dielectric nanoantenna can be realized as an optically small spherical dielectric nanoparticle with a notch excited by a point source (e.g. a quantum dot) located in the notch. The superdirectivity effect is not associated with high dissipative losses. For these dielectric nanoantennas we predict the effect of the beam steering at the nanoscale characterized by a subwavelength sensitivity of the beam radiation direction to the source position. We confirm the predicted effects experimentally through the scaling to the microwave frequency range.

  15. 1-D ELECTRO-OPTIC BEAM STEERING DEVICE

    OpenAIRE

    Wang, Wei-Chih; Tsui, Chi Leung

    2011-01-01

    In this paper, we present the design and fabrication of a 1D beam steering device based on planar electro-optic thermal-plastic prisms and a collimator lens array. With the elimination of moving parts, the proposed device is able to overcome the mechanical limitations of present scanning devices, such as fatigue and low operating frequency, while maintaining a small system footprint (~0.5mm×0.5mm). From experimental data, our prototype device is able to achieve a maximum deflection angle of 5...

  16. Differential methods for the steering of acoustic phased arrays

    International Nuclear Information System (INIS)

    An extension of the traditional method of phase compensation for acoustic phased array systems (microphone ar-rays) will be presented in this paper. Contrary to the traditional procedure of delay-and-sum-beam forming, which exhibits a maximum of the antenna's directivity pattern in the steering direction of the array, the new method pro-posed here is using a set of additional directivity patterns which have a distinct zero in the focal direction. Utilizing this set allows the computation of point spread functions with completely new and advantageous properties that are unachievable in principle by means of classical beam forming.

  17. AN ALGORITHM FOR STEERING CONTROL WITH SIMULATION RESULTS

    OpenAIRE

    Apeksha V. Sakhare,; Prof. Dr. V. M. Thakare; Prof. R. V. Dharaskar

    2010-01-01

    The idea behind the paper was channelization of human thoughts to automated realization. It is decided to implement the theme of automatic maneuvering of vehicles and the unanimous choice of sensor was touch screen. It was started with the thought of being able to replace the steering of a car completely by a touch screen. It is drawn on the experience of driving to reach at the choice of touch screen as a drive interface. Another innovation was the touch screen controller being wireless. The...

  18. High power transcranial beam steering for ultrasonic brain therapy.

    OpenAIRE

    PERNOT, mathieu; Aubry, Jean-François; Tanter, Mickaël; Thomas, Jean-Louis; Fink, Mathias

    2003-01-01

    International audience A sparse phased array is specially designed for non-invasive ultrasound transskull brain therapy. The array is made of 200 single elements corresponding to a new generation of high power transducers developed in collaboration with Imasonic (Besançon, France). Each element has a surface of 0.5 cm2 and works at 0.9 MHz central frequency with a maximum 20 W cm(-2) intensity on the transducer surface. In order to optimize the steering capabilities of the array, several t...

  19. Hierarchical Visual Analysis and Steering Framework for Astrophysical Simulations

    Institute of Scientific and Technical Information of China (English)

    肖健; 张加万; 原野; 周鑫; 纪丽; 孙济洲

    2015-01-01

    A framework for accelerating modern long-running astrophysical simulations is presented, which is based on a hierarchical architecture where computational steering in the high-resolution run is performed under the guide of knowledge obtained in the gradually refined ensemble analyses. Several visualization schemes for facilitating ensem-ble management, error analysis, parameter grouping and tuning are also integrated owing to the pluggable modular design. The proposed approach is prototyped based on the Flash code, and it can be extended by introducing user-defined visualization for specific requirements. Two real-world simulations, i.e., stellar wind and supernova remnant, are carried out to verify the proposed approach.

  20. Orbit Steering and Central Frequency for LEP2 Energy Calibration

    CERN Document Server

    Wenninger, J

    2000-01-01

    "The central frequency is an important parameter of the LEP beam energy model. It is a direct measurementof the LEP circumference and is used to evaluate the contribution of the quadrupoles to field integral relevant forthe LEP beam ebergy. Its evolution over a run is tracked using direct frequency measurementscombined with radial beam position measurements in the LEP arcs.The influence of orbit corrections on the central frequency measurement techniques was evaluatedand a model allowing to correct for changes of corrector settings was developped.The central frequency data for the LEP2 runs between 1996 and 1999 was re-analysed to includecorrections due to the closed orbit steering."

  1. Multi-targeted inhibition of tumor growth and lung metastasis by redox-sensitive shell crosslinked micelles loading disulfiram

    Science.gov (United States)

    Duan, Xiaopin; Xiao, Jisheng; Yin, Qi; Zhang, Zhiwen; Yu, Haijun; Mao, Shirui; Li, Yaping

    2014-03-01

    Metastasis, the main cause of cancer related deaths, remains the greatest challenge in cancer treatment. Disulfiram (DSF), which has multi-targeted anti-tumor activity, was encapsulated into redox-sensitive shell crosslinked micelles to achieve intracellular targeted delivery and finally inhibit tumor growth and metastasis. The crosslinked micelles demonstrated good stability in circulation and specifically released DSF under a reductive environment that mimicked the intracellular conditions of tumor cells. As a result, the DSF-loaded redox-sensitive shell crosslinked micelles (DCMs) dramatically inhibited cell proliferation, induced cell apoptosis and suppressed cell invasion, as well as impairing tube formation of HMEC-1 cells. In addition, the DCMs could accumulate in tumor tissue and stay there for a long time, thereby causing significant inhibition of 4T1 tumor growth and marked prevention in lung metastasis of 4T1 tumors. These results suggested that DCMs could be a promising delivery system in inhibiting the growth and metastasis of breast cancer.

  2. Redox-control of the alarmin, Interleukin-1α

    Directory of Open Access Journals (Sweden)

    Donald A. McCarthy

    2013-01-01

    Full Text Available The pro-inflammatory cytokine Interleukin-1α (IL-1α has recently emerged as a susceptibility marker for a wide array of inflammatory diseases associated with oxidative stress including Alzheimer's, arthritis, atherosclerosis, diabetes and cancer. In the present study, we establish that expression and nuclear localization of IL-1α are redox-dependent. Shifts in steady-state H2O2 concentrations (SS-[H2O2] resulting from enforced expression of manganese superoxide dismutase (SOD2 drive IL-1α mRNA and protein expression. The redox-dependent expression of IL-1α is accompanied by its increased nuclear localization. Both IL-1α expression and its nuclear residency are abrogated by catalase co-expression. Sub-lethal doses of H2O2 also cause IL-1α nuclear localization. Mutagenesis revealed IL-1α nuclear localization does not involve oxidation of cysteines within its N terminal domain. Inhibition of the processing enzyme calpain prevents IL-1α nuclear localization even in the presence of H2O2. H2O2 treatment caused extracellular Ca2+ influx suggesting oxidants may influence calpain activity indirectly through extracellular Ca2+ mobilization. Functionally, as a result of its nuclear activity, IL-1α overexpression promotes NF-kB activity, but also interacts with the histone acetyl transferase (HAT p300. Together, these findings demonstrate a mechanism by which oxidants impact inflammation through IL-1α and suggest that antioxidant-based therapies may prove useful in limiting inflammatory disease progression.

  3. Carcass characteristics and composition of Brahman, angus and Brahman x Angus steers fed for different times-on-feed.

    Science.gov (United States)

    Lunt, D K; Smith, G C; Murphey, C E; Savell, J W; Carpenter, Z L; Petersen, H D

    1985-01-01

    Twenty-five steers of each of three breedtypes (Angus, Brahman and F(1) Brahman x Angus) were sorted by frame size and muscle thickness, assigned to groups (five steers of each breedtype) to be fed for 0, 56, 112, 168 or 224 days, slaughtered and compared for various carcass traits. Steers of each breedtype had similar dressing percentages. Carcasses from all three breedtypes merited similar USDA quality and yield grades; breedtypes differences in quality grade were slight. Differences were found in the fat deposition patterns exhibited by the three breedtypes. Brahman steers tended to deposit more of their total fat as subcutaneous fat early in the feeding period. Angus steers had more (P Brahman steers. Brahman steers had a higher percentage of their separable lean in the muscles of the round than did steers of the other breedtypes. PMID:22055933

  4. Design and Development of Labview Based Steering Wheel Angle Sensor System

    Directory of Open Access Journals (Sweden)

    Tony George

    2015-04-01

    Full Text Available Conventional angle sensors can measure only 360°,but passenger car steering wheel turns through +/-720o (a total of 4 complete turns. In this paper we describe iGMR based steering wheel angle sensor implementation which can be used as a rotation sensor to measure +/- 720°.

  5. Throughput-Based Traffic Steering in LTE-Advanced HetNet Deployments

    DEFF Research Database (Denmark)

    Gimenez, Lucas Chavarria; Kovacs, Istvan Z.; Wigard, Jeroen;

    2015-01-01

    The objective of this paper is to propose traffic steering solutions that aim at optimizing the end-user throughput. Two different implementations of an active mode throughput-based traffic steering algorithm for Heterogeneous Networks (HetNet) are introduced. One that always forces handover of the...

  6. A 24-GHz Automotive Radar Transmitter with Digital Beam Steering in 130-nm CMOS

    OpenAIRE

    Wernehag, Johan; Sjöland, Henrik

    2006-01-01

    In this paper simulations of a 130-nm CMOS 24-GHz automotive radar transmitter with digital beam steering is presented. The beam steering is performed by multiple PAs connected to separate antenna elements. The output phases of the PAs are individually controllable through 360

  7. A steering magnet optimized by random search method for high current beam transport line

    International Nuclear Information System (INIS)

    We present an improved design of the steering magnet which produces almost uniform magnetic field in the region through which beam passes. Optimization of the parameters of the steering magnet is done by random search method. It is shown that use of a suitable shim reduces the field deviation by a great extent. (author)

  8. Research of two-dimensional beam steering in LCOS-based wavelength selective switch.

    Science.gov (United States)

    Yang, Dongtang; He, Cheng; Jing, Zean; Luo, Fengguang

    2015-05-10

    The phenomenon of two-dimensional beam steering in liquid crystal on silicon (LCOS) is demonstrated. We propose a novel flexible wavelength selective switch (WSS) using LCOS two-dimensional beam steering. The cross talk of adjacent channel in the WSS is theoretically small, while the measured insert loss is lower than 15 dB. PMID:25967496

  9. Demonstration of all-optical beam steering in modulated photonic lattices

    OpenAIRE

    Rosberg, Christian R.; Garanovich, Ivan L.; Sukhorukov, Andrey A.; Neshev, Dragomir N.; Krolikowski, Wieslaw; Kivshar, Yuri S.

    2005-01-01

    We demonstrate experimentally all-optical beam steering in modulated photonic lattices induced optically by three beam interference in a biased photorefractive crystal. We identify and characterize the key physical parameters governing the beam steering, and show that the spatial resolution can be enhanced by the additional effect of nonlinear beam self-localization.

  10. A theoretical model of speed-dependent steering torque for rolling tyres

    Science.gov (United States)

    Wei, Yintao; Oertel, Christian; Liu, Yahui; Li, Xuebing

    2016-04-01

    It is well known that the tyre steering torque is highly dependent on the tyre rolling speed. In limited cases, i.e. parking manoeuvre, the steering torque approaches the maximum. With the increasing tyre speed, the steering torque decreased rapidly. Accurate modelling of the speed-dependent behaviour for the tyre steering torque is a key factor to calibrate the electric power steering (EPS) system and tune the handling performance of vehicles. However, no satisfactory theoretical model can be found in the existing literature to explain this phenomenon. This paper proposes a new theoretical framework to model this important tyre behaviour, which includes three key factors: (1) tyre three-dimensional transient rolling kinematics with turn-slip; (2) dynamical force and moment generation; and (3) the mixed Lagrange-Euler method for contact deformation solving. A nonlinear finite-element code has been developed to implement the proposed approach. It can be found that the main mechanism for the speed-dependent steering torque is due to turn-slip-related kinematics. This paper provides a theory to explain the complex mechanism of the tyre steering torque generation, which helps to understand the speed-dependent tyre steering torque, tyre road feeling and EPS calibration.

  11. PRELIMINARY GRAZING STUDIES WITH RUMEN-FISTULATED STEERS AT SELECTED NUCLEAR-TEST SITES

    Science.gov (United States)

    Rumen-fistulated steers (steers with a capped tube inserted into a permanent surgical opening into the stomach) were allowed to graze the fallout zones of six selected nuclear-test sites on the Nevada Test Site and Tonopah Test Range. Ingesta samples were analyzed for radionuclid...

  12. Towards a flexible IT-based system for process steering in architecture design.

    OpenAIRE

    Laaroussi, Ahmed; Zarli, Alain; Bignon, Jean-Claude; Halin, Gilles

    2007-01-01

    This paper tackles the problem of assisting the steering distributed design processes in architecture. It suggests a macro model oriented steering, based on breakpoints notion borrowed from computer field. We formalize the use of breakpoint into process based on two notions: Concern Situation and Aimed Situation. A first software implementation is tried starting from this modelling.

  13. Hybrid Einstein-Podolsky-Rosen steering in an atom-optomechanical system

    Science.gov (United States)

    Tan, Huatang; Sun, Lihui

    2015-12-01

    Einstein-Podolsky-Rosen steering manifests a type of quantum correlations intermediate between entanglement and Bell nonlocality. In this paper we propose a scheme for realizing hybrid atom-mechanical quantum steering in the steady-state regime. In our scheme, an optomechanical two-mode cavity is coupled to a distant ensemble of double-λ atoms in a cascade way, which induces the dissipative interaction between the mechanics and the internal atomic states. We show that strong cavity dissipation can lead to two-way atom-mechanical steering and the optimal steering exhibited in an approximate two-mode squeezed-vacuum atom-mechanical state. Moreover, we find that for the present cascade coupling scheme, the one-way steering from the mechanical oscillator to the atoms is achievable under certain conditions, while the reverse one-way steering is impossible to obtain. The reason for achieving the asymmetric steering is analyzed and the effect of mechanical thermal noise on the steering is also studied.

  14. Seamustard (Undaria pinnatifida) Improves Growth, Immunity, Fatty Acid Profile and Reduces Cholesterol in Hanwoo Steers

    OpenAIRE

    Hwang, J. A.; Islam, M. M.; Ahmed, S. T.; Mun, H. S.; G. M. Kim; Kim, Y. J.; Yang, C. J.

    2014-01-01

    The study was designed to evaluate the effect of 2% seamustard (Undaria pinnatifida) by-product (SW) on growth performance, immunity, carcass characteristics, cholesterol content and fatty acid profile in Hanwoo steers. A total of 20 Hanwoo steers (ave. 22 months old; 619 kg body weight) were randomly assigned to control (basal diet) and 2% SW supplemented diet. Dietary SW supplementation significantly (p

  15. On Using Current Steering Logic in Mixed Analogue-digital Circuits

    DEFF Research Database (Denmark)

    Lehmann, Torsten

    1998-01-01

    The authors investigate power supply noise in mixed analogue-digital circuits, arising from communication between the analogue and digital parts of the circuit. Current steering techniques and proper buffering are used to show which noise currents can be reduced and which cannot. In addition, a...... high-swing current steering buffer for driving analogue switches or external digital signals is proposed....

  16. Ministerial Steering and Institutional Responses: Recent Developments of the Finnish Higher Education System in Germany.

    Science.gov (United States)

    Holtta, Sepp; Rekila, Eila

    2003-01-01

    Studied recent changes in the higher education system of Finland through two studies, one on the change in governmental steering instruments from the mid-1980s to the present and one on the institutional reaction to the new steering-by-results model. Data from various sources provide details of the reformulation of higher education policy. (SLD)

  17. Mid-sized omnidirectional robot with hydraulic drive and steering

    Science.gov (United States)

    Wood, Carl G.; Perry, Trent; Cook, Douglas; Maxfield, Russell; Davidson, Morgan E.

    2003-09-01

    Through funding from the US Army-Tank-Automotive and Armaments Command's (TACOM) Intelligent Mobility Program, Utah State University's (USU) Center for Self-Organizing and Intelligent Systems (CSOIS) has developed the T-series of omni-directional robots based on the USU omni-directional vehicle (ODV) technology. The ODV provides independent computer control of steering and drive in a single wheel assembly. By putting multiple omni-directional (OD) wheels on a chassis, a vehicle is capable of uncoupled translational and rotational motion. Previous robots in the series, the T1, T2, T3, ODIS, ODIS-T, and ODIS-S have all used OD wheels based on electric motors. The T4 weighs approximately 1400 lbs and features a 4-wheel drive wheel configuration. Each wheel assembly consists of a hydraulic drive motor and a hydraulic steering motor. A gasoline engine is used to power both the hydraulic and electrical systems. The paper presents an overview of the mechanical design of the vehicle as well as potential uses of this technology in fielded systems.

  18. Adiabatic photo-steering theory in topological insulators

    International Nuclear Information System (INIS)

    Feasible external control of material properties is a crucial issue in condensed matter physics. A new approach to achieving this aim, named adiabatic photo-steering, is reviewed. The core principle of this scheme is that several material constants are effectively turned into externally tunable variables by irradiation of monochromatic laser light. Two-dimensional topological insulators are selected as the optimal systems that exhibit a prominent change in their properties following the application of this method. Two specific examples of photo-steered quantum phenomena, which reflect topological aspects of the electronic systems at hand, are presented. One is the integer quantum Hall effect described by the Haldane model, and the other is the quantum spin Hall effect described by the Kane–Mele model. The topological quantities associated with these phenomena are the conventional Chern number and spin Chern number, respectively. A recent interesting idea, time-reversal symmetry breaking via a temporary periodic external stimulation, is also discussed. (focus issue review)

  19. The steering committee for the marketing of radurised foods

    International Nuclear Information System (INIS)

    After the very successful results obtained during the initial research stage of food irradiation, a need was felt for the commercial application of the process. Although few, if any, other food processing methods have been so thoroughly investigated prior to acceptance, several factors influenced the spontaneous implementation thereof. A definite need for co-ordination of commercial trials and proper commercial introduction of the process which invited so many discussions world-wide, led to the introduction of the Steering Committee for Radurised Foodstuffs in South Africa by the Minister of Agriculture during 1981. The Steering Committee was established to advise the Minister of Agriculture regarding the acceptability of the process and the progress made in this regard. The Minister of Agriculture (now Agricultural Economics and Water Affairs) fulfills an important role in the marketing of agricultural products in South Africa. Many decisions and recommendations of Organised Agriculture and of the different Marketing Boards are subject to the final approval or acceptance by the Minister. It is therefore important that he will be informed and advised regarding radurisation of foodstuffs and related aspects

  20. Ultrasound-guided robot for flexible needle steering.

    Science.gov (United States)

    Neubach, Zipi; Shoham, Moshe

    2010-04-01

    The success rate of medical procedures involving needle insertion is often directly related to needle placement accuracy. Due to inherent limitations of commonly used freehand needle placement techniques, there is a need for a system providing for controlled needle steering for procedures that demand high positional accuracy. This paper describes a robotic system developed for flexible needle steering inside soft tissues under real-time ultrasound imaging. An inverse kinematics algorithm based on a virtual spring model is applied to calculate needle base manipulations required for the tip to follow a curved trajectory while avoiding physiological obstacles. The needle tip position is derived from ultrasound images and is used in calculations to minimize the tracking error, enabling a closed-loop needle insertion. In addition, as tissue stiffness is a necessary input to the control algorithm, a novel method to classify tissue stiffness from localized tissue displacements is proposed and shown to successfully distinguish between soft and stiff tissue. The system performance was experimentally verified by robotic manipulation of the needle base inside a phantom with layers of varying stiffnesses. The closed-loop experiment with updated tissue stiffness parameters demonstrated a needle-tip tracking error of approximately 1 mm and proved to be significantly more accurate than the freehand method. PMID:19709957

  1. Advanced Optics for the Remote Steering ITER ECRH Upper Launcher

    Science.gov (United States)

    Bruschi, A.; Cirant, S.; Moro, A.; Platania, P.; Sozzi, C.

    2005-01-01

    The optics of the ECRH Upper Launcher in ITER based on the Remote Steering concept needs special attention, since any focussing element in front of the waveguide has combined effects on the range of steering angles achievable and the beam width in the plasma region. The effects are studied in detail for a setup composed by 8 beams per port (three ports), for a spherical and a hyperbolic mirror surface. Gaussian beam analysis is compared to beam pattern calculations with the optical physics code GRASP, in order to verify the validity of gaussian optics approximation. The standard description with simply astigmatic beams, not adequate in more complex systems as the proposed two-mirror set-up, requires approximations, which are compared with the generalized astigmatic beam description. The ohmic losses at the end mirrors and the related localized heating due to the very large power density cause deformations that depends on the design of the cooling circuit. The distortion of the beam shape has been evaluated in a realistic case of mirror cooling with a small-channel system. The quantification of the effect depends on the precise evaluation ohmic losses and their enhancement in the long term due to the surface deterioration.

  2. Advanced Optics for the Remote Steering ITER ECRH Upper Launcher

    International Nuclear Information System (INIS)

    The optics of the ECRH Upper Launcher in ITER based on the Remote Steering concept needs special attention, since any focussing element in front of the waveguide has combined effects on the range of steering angles achievable and the beam width in the plasma region. The effects are studied in detail for a setup composed by 8 beams per port (three ports), for a spherical and a hyperbolic mirror surface. Gaussian beam analysis is compared to beam pattern calculations with the optical physics code GRASP, in order to verify the validity of gaussian optics approximation. The standard description with simply astigmatic beams, not adequate in more complex systems as the proposed two-mirror set-up, requires approximations, which are compared with the generalized astigmatic beam description. The ohmic losses at the end mirrors and the related localized heating due to the very large power density cause deformations that depends on the design of the cooling circuit. The distortion of the beam shape has been evaluated in a realistic case of mirror cooling with a small-channel system. The quantification of the effect depends on the precise evaluation ohmic losses and their enhancement in the long term due to the surface deterioration

  3. Stability Simulation of a Vehicle with Wheel Active Steering

    Directory of Open Access Journals (Sweden)

    Brabec Pavel

    2016-01-01

    Full Text Available This paper deals with the possibility of increasing the vehicle driving stability at a higher speed. One of the ways how to achieve higher stability is using the 4WS system. Mathematical description of vehicle general movement is a very complex task. For simulation, models which are aptly simplified are used. For the first approach, so-called single-truck vehicle model (often linear is usually used. For the simulation, we have chosen to extend the model into a two-truck one, which includes the possibility to input more vehicle parameters. Considering the 4WS system, it is possible to use a number of potential regulations. In our simulation model, the regulation system with compound coupling was used. This type of regulation turns the rear wheels depending on the input parameters of the system (steering angle of the front wheels and depending on the output moving quantities of the vehicle, most frequently the yaw rate. Criterion for compensation of lateral deflection centre of gravity angle is its zero value, or more precisely the zero value of its first-order derivative. Parameters and set-up of the simulation model were done in conjunction with the dSAPACE software. Reference performances of the vehicle simulation model were made through the defined manoeuvres. But the simulation results indicate that the rear-wheels steering can have a positive effect on the vehicle movement stability, especially when changing the driving direction at high speed.

  4. Radiation focusing, guiding and steering in free electron lasers

    International Nuclear Information System (INIS)

    In a free electron laser (FEL), the radiation field, wiggler field and electron beam resonantly couple and modify the refractive index in the vicinity of the electron beam. The refractive index is modified such that the radiation beam will tend to focus upon the electron beam. A method for solving the 3-D wave equation for the FEL process is outlined. This approach, called the source dependent expansion method, provides an excellent analytical and numerical technique for studying optical focusing, guiding and steering in FELs. A radiation envelope equation is derived. Conditions and parameters necessary to achieve guided radiation beams (constant radius) in the exponential gain regime are obtained for FELs driven by either induction linacs or rf linacs. Immediately prior to saturation in the exponential gain region, the podermotive potential is large enough to trap the beam electrons. The wiggler field, at this point, could be tapered to further increase the operating efficiency. The possibility of bending or steering radiation beams in FELs is discussed and a condition necessary for radiation guiding along a curved electron beam orbit is obtained

  5. Ka-band MMIC beam steered transmitter array

    Science.gov (United States)

    Rascoe, D. L.; Riley, A. L.; Huang, J.; Lubecke, V.; Duffy, L.

    1989-01-01

    A 32-GHz six-element linear transmitter array utilizing monolithic microwave integrated circuit (MMIC) phase shifters and power amplifiers was designed and tested as part of the development of a spacecraft array feed for NASA deep-space communications applications. Measurements of the performance of individual phase shifters, power amplifiers, and microstrip radiators were carried out, and electronic beam steering of the linear array was demonstrated. The switched-line phase shifters were accurate to within 7 percent on average and the power amplifier 1-dB compressed output power varied over 0.3 dB. The array had a beamwidth of 7.5 deg and demonstrated acceptable beam steering over + or - 8 deg. From the results, it can be concluded that this MMIC phased array has adequate beam-scanning capability for use in the two-dimensional array. The areas that need to be improved are the efficiency of the MMIC power amplifier and the insertion loss of the MMIC phase shifter.

  6. High power transcranial beam steering for ultrasonic brain therapy

    International Nuclear Information System (INIS)

    A sparse phased array is specially designed for non-invasive ultrasound transskull brain therapy. The array is made of 200 single elements corresponding to a new generation of high power transducers developed in collaboration with Imasonic (Besancon, France). Each element has a surface of 0.5 cm2 and works at 0.9 MHz central frequency with a maximum 20 W cm-2 intensity on the transducer surface. In order to optimize the steering capabilities of the array, several transducer distributions on a spherical surface are simulated: hexagonal, annular and quasi-random distributions. Using a quasi-random distribution significantly reduces the grating lobes. Furthermore, the simulations show the capability of the quasi-random array to electronically move the focal spot in the vicinity of the geometrical focus (up to ±15 mm). Based on the simulation study, the array is constructed and tested. The skull aberrations are corrected by using a time reversal mirror with amplitude correction achieved thanks to an implantable hydrophone, and a sharp focus is obtained through a human skull. Several lesions are induced in fresh liver and brain samples through human skulls, demonstrating the accuracy and the steering capabilities of the system

  7. Steered Molecular Dynamics Methods Applied to Enzyme Mechanism and Energetics.

    Science.gov (United States)

    Ramírez, C L; Martí, M A; Roitberg, A E

    2016-01-01

    One of the main goals of chemistry is to understand the underlying principles of chemical reactions, in terms of both its reaction mechanism and the thermodynamics that govern it. Using hybrid quantum mechanics/molecular mechanics (QM/MM)-based methods in combination with a biased sampling scheme, it is possible to simulate chemical reactions occurring inside complex environments such as an enzyme, or aqueous solution, and determining the corresponding free energy profile, which provides direct comparison with experimental determined kinetic and equilibrium parameters. Among the most promising biasing schemes is the multiple steered molecular dynamics method, which in combination with Jarzynski's Relationship (JR) allows obtaining the equilibrium free energy profile, from a finite set of nonequilibrium reactive trajectories by exponentially averaging the individual work profiles. However, obtaining statistically converged and accurate profiles is far from easy and may result in increased computational cost if the selected steering speed and number of trajectories are inappropriately chosen. In this small review, using the extensively studied chorismate to prephenate conversion reaction, we first present a systematic study of how key parameters such as pulling speed, number of trajectories, and reaction progress are related to the resulting work distributions and in turn the accuracy of the free energy obtained with JR. Second, and in the context of QM/MM strategies, we introduce the Hybrid Differential Relaxation Algorithm, and show how it allows obtaining more accurate free energy profiles using faster pulling speeds and smaller number of trajectories and thus smaller computational cost. PMID:27497165

  8. Muscle Growth and Distribution in Fattening Steer of Different Breeds

    Directory of Open Access Journals (Sweden)

    R. Priyanto

    2011-04-01

    Full Text Available The breed patterns in growth and distribution of muscle were studied using three breeds of beef cattle entering fattening phase. This study involved 23 grass-fed steer Brahman, 24 Hereford and 22 Brahman x Hereford crosses with a live weight range of 300 to 600 kgs. An allometric Huxley model was used to study the growth and distribution patterns of muscle tissue within wholesale cut. There were several cuts in which the muscle growth coefficients were significantly different among breeds. Comparisons of muscle weight distribution at log natural of 75 kg side muscle + bone weight (4.313 kg generally showed significant between-breed differences. Herefords tended to have more muscles in their wholesale cuts than Brahmans and/or Brahman x Hereford crosses, except the muscles in Tenderloin, Rib Set and Chuck. Brahmans had heavier Topside and Silverside than Herefords and Brahman x Hereford crosses and the differences were maintained at log natural of 114 kg side muscle + bone weight (4.733 kg. At this heavier weight, there was a general tendency for Brahmans to have more muscle in their wholesale cuts than the Brahman x Hereford steers, except the muscle in Loin and Neck + Sticking.

  9. Electrowetting-Controlled Dual Liquid Prism for Adaptive Beam Steering

    Science.gov (United States)

    Cheng, Jiangtao

    2015-03-01

    The use of concentrating photovoltaic (CPV) technology has been the most promising method of harvesting solar radiation. These CPV systems often require motor-driven tracking devices to steer the sun's beams onto solar cells. The cost of maintaining these tracking systems is the primary inhibitor for widespread application. We aim to overcome the need for mechanical trackers through the use of an electrowetting-driven solar tracking (EWST) system. The electrowetting-driven solar tracking system consists of an array of novel electrowetting-controlled dual liquid prisms, which are filled with immiscible fluids that have large differences in refractive indices. The naturally formed meniscus between the fluids can function as a dynamic optical prism. Via the full-range modulation of the liquid prisms, incident sunlight can be adaptively tracked, steered, and focused onto CPV cells through a fixed optical condenser. Furthermore, unlike the conventional and cumbersome motor-driven tracking systems used today, the liquid prism system would be suitable for rooftop applications. The results of this project reveal that the EWST system has the potential to generate ~ 70% more green energy at 50% of the conventional capital cost.

  10. Certifying Einstein-Podolsky-Rosen steering via the local uncertainty principle

    Science.gov (United States)

    Zhen, Yi-Zheng; Zheng, Yu-Lin; Cao, Wen-Fei; Li, Li; Chen, Zeng-Bing; Liu, Nai-Le; Chen, Kai

    2016-01-01

    Uncertainty principle lies at the heart of quantum mechanics, while nonlocality is an intriguing phenomenon of quantum mechanics to rule out local causal theories. One subtle form of nonlocality is so-called Einstein-Podolsky-Rosen (EPR) steering, which holds the potential for shared entanglement verification even if the one-sided measurement device is untrusted. However, certifying EPR steering remains a big challenge presently. Here, we employ the local uncertainty relation to provide an experimental friendly approach for EPR steering verification. We show that the strength of EPR steering is quantitatively linked to the strength of the uncertainty relation, as well as the amount of entanglement. We find also that the realignment method works for detecting EPR steering of an arbitrary dimensional system.

  11. Redox-active cerium oxide nanoparticles protect human dermal fibroblasts from PQ-induced damage

    Directory of Open Access Journals (Sweden)

    Claudia von Montfort

    2015-04-01

    Full Text Available Recently, it has been published that cerium (Ce oxide nanoparticles (CNP; nanoceria are able to downregulate tumor invasion in cancer cell lines. Redox-active CNP exhibit both selective pro-oxidative and antioxidative properties, the first being responsible for impairment of tumor growth and invasion. A non-toxic and even protective effect of CNP in human dermal fibroblasts (HDF has already been observed. However, the effect on important parameters such as cell death, proliferation and redox state of the cells needs further clarification. Here, we present that nanoceria prevent HDF from reactive oxygen species (ROS-induced cell death and stimulate proliferation due to the antioxidative property of these particles.

  12. Advanced Materials for Redox Flow Batteries

    OpenAIRE

    Friedl, Jochen

    2015-01-01

    We investigate two advanced materials electrochemically in order to see if they can be applied to improve energy- and power-density of Redox Flow Batteries (RFBs). First, multi-walled carbon nanotubes are analyzed as electrode material for the All-Vanadium RFB. We discovered that an enhanced activity assigned by previous studies was a misinterpretation caused by an apparent catalytic effect. Second, large inorganic molecules, polyoxometalates (POMs), were investigated as nano-sized el...

  13. Progress of all vanadium redox flow batteries

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ Aresearch team headed by Prof.ZHANG Huamin from the CAS Dalian Institute of Chemical Physics has made important progress in the research and development of a LED screen demo system powered by vanadium redox flow batteries (VRB).The system has operated continuously for over one year without any malfunction.So far,the total running time is up to 11,000 hours.

  14. Electrochemical determination of thioredoxin redox states

    Czech Academy of Sciences Publication Activity Database

    Dorčák, Vlastimil; Paleček, Emil

    2009-01-01

    Roč. 81, č. 4 (2009), s. 1543-1548. ISSN 0003-2700 R&D Projects: GA AV ČR(CZ) KAN400310651; GA ČR(CZ) GA301/07/0490; GA MŠk(CZ) LC06035 Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702 Keywords : thioredoxin redox states * constant current chronopotentiometric stripping * carbon and mercury electrodes Subject RIV: BO - Biophysics Impact factor: 5.214, year: 2009

  15. Redox Flow Batteries, Hydrogen and Distributed Storage

    OpenAIRE

    Dennison, C. R.; Vrubel, Heron; Amstutz, Véronique; Peljo, Pekka Eero; Toghill, Kathryn E.; Girault, Hubert

    2015-01-01

    Social, economic, and political pressures are causing a shift in the global energy mix, with a preference toward renewable energy sources. In order to realize widespread implementation of these resources, large-scale storage of renewable energy is needed. Among the proposed energy storage technologies, redox flow batteries offer many unique advantages. The primary limitation of these systems, however, is their limited energy density which necessitates very large installations. In order to enh...

  16. Reactive oxygen species and redox compartmentalization

    OpenAIRE

    Kaludercic, Nina; Deshwal, Soni; Di Lisa, Fabio

    2014-01-01

    Reactive oxygen species (ROS) formation and signaling are of major importance and regulate a number of processes in physiological conditions. A disruption in redox status regulation, however, has been associated with numerous pathological conditions. In recent years it has become increasingly clear that oxidative and reductive modifications are confined in a spatio-temporal manner. This makes ROS signaling similar to that of Ca2+ or other second messengers. Some subcellular compartments are m...

  17. Redox Regulation in Amyotrophic Lateral Sclerosis

    Directory of Open Access Journals (Sweden)

    Sonam Parakh

    2013-01-01

    Full Text Available Amyotrophic lateral sclerosis (ALS is a neurodegenerative disease that results from the death of upper and lower motor neurons. Due to a lack of effective treatment, it is imperative to understand the underlying mechanisms and processes involved in disease progression. Regulations in cellular reduction/oxidation (redox processes are being increasingly implicated in disease. Here we discuss the possible involvement of redox dysregulation in the pathophysiology of ALS, either as a cause of cellular abnormalities or a consequence. We focus on its possible role in oxidative stress, protein misfolding, glutamate excitotoxicity, lipid peroxidation and cholesterol esterification, mitochondrial dysfunction, impaired axonal transport and neurofilament aggregation, autophagic stress, and endoplasmic reticulum (ER stress. We also speculate that an ER chaperone protein disulphide isomerase (PDI could play a key role in this dysregulation. PDI is essential for normal protein folding by oxidation and reduction of disulphide bonds, and hence any disruption to this process may have consequences for motor neurons. Addressing the mechanism underlying redox regulation and dysregulation may therefore help to unravel the molecular mechanism involved in ALS.

  18. Membrane development for vanadium redox flow batteries.

    Science.gov (United States)

    Schwenzer, Birgit; Zhang, Jianlu; Kim, Soowhan; Li, Liyu; Liu, Jun; Yang, Zhenguo

    2011-10-17

    Large-scale energy storage has become the main bottleneck for increasing the percentage of renewable energy in our electricity grids. Redox flow batteries are considered to be among the best options for electricity storage in the megawatt range and large demonstration systems have already been installed. Although the full technological potential of these systems has not been reached yet, currently the main problem hindering more widespread commercialization is the high cost of redox flow batteries. Nafion, as the preferred membrane material, is responsible for about 11% of the overall cost of a 1 MW/8 MWh system. Therefore, in recent years two main membrane related research threads have emerged: 1) chemical and physical modification of Nafion membranes to optimize their properties with regard to vanadium redox flow battery (VRFB) application; and 2) replacement of the Nafion membranes with different, less expensive materials. This review summarizes the underlying basic scientific issues associated with membrane use in VRFBs and presents an overview of membrane-related research approaches aimed at improving the efficiency of VRFBs and making the technology cost-competitive. Promising research strategies and materials are identified and suggestions are provided on how materials issues could be overcome. PMID:22102992

  19. Membrane Development for Vanadium Redox Flow Batteries

    Energy Technology Data Exchange (ETDEWEB)

    Schwenzer, Birgit; Zhang, Jianlu; Kim, Soowhan; Li, Liyu; Liu, Jun; Yang, Zhenguo

    2011-10-17

    Large-scale energy storage has become a main bottleneck for increasing the percentage of renewable energy in our electricity grids. Redox flow batteries are considered to be among the best options for electricity storage in the megawatt range, and large demonstration systems have already been installed. Although the full technological potential of these systems has not been reached yet, currently the main problem hindering more widespread commercialization is the high cost of redox flow batteries. Nafion{reg_sign} as the preferred membrane material is responsible for {approx}11% of the overall cost of a 1 MW/8 MWh system. Therefore in recent years two main membrane-related research threads have emerged: (a) chemical and physical modification of Nafion membranes to optimize their properties with regard to vanadium redox flow battery (VRFB) application; and (b) replacement of the Nafion membranes with different, less expensive materials. This review summarizes the underlying basic science issues associated with membrane use in VRFBs and presents an overview of membrane-related research approaches aimed at improving the efficiency of VRFBs and making the technology cost-competitive. Promising research strategies and materials are identified and suggestions are provided on how materials issues could be overcome.

  20. Measurement of Redox Potential in Nanoecotoxicological Investigations

    Directory of Open Access Journals (Sweden)

    Ratna Tantra

    2012-01-01

    Full Text Available Redox potential has been identified by the Organisation for Economic Co-operation and Development (OECD as one of the parameters that should be investigated for the testing of manufactured nanomaterials. There is still some ambiguity concerning this parameter, i.e., as to what and how to measure, particularly when in a nanoecotoxicological context. In this study the redox potentials of six nanomaterials (either zinc oxide (ZnO or cerium oxide (CeO2 dispersions were measured using an oxidation-reduction potential (ORP electrode probe. The particles under testing differed in terms of their particle size and dispersion stability in deionised water and in various ecotox media. The ORP values of the various dispersions and how they fluctuate relative to each other are discussed. Results show that the ORP values are mainly governed by the type of liquid media employed, with little contributions from the nanoparticles. Seawater was shown to have reduced the ORP value, which was attributed to an increase in the concentration of reducing agents such as sulphites or the reduction of dissolved oxygen concentration. The lack of redox potential value contribution from the particles themselves is thought to be due to insufficient interaction of the particles at the Pt electrode of the ORP probe.

  1. Measurement of redox potential in nanoecotoxicological investigations.

    Science.gov (United States)

    Tantra, Ratna; Cackett, Alex; Peck, Roger; Gohil, Dipak; Snowden, Jacqueline

    2012-01-01

    Redox potential has been identified by the Organisation for Economic Co-operation and Development (OECD) as one of the parameters that should be investigated for the testing of manufactured nanomaterials. There is still some ambiguity concerning this parameter, i.e., as to what and how to measure, particularly when in a nanoecotoxicological context. In this study the redox potentials of six nanomaterials (either zinc oxide (ZnO) or cerium oxide (CeO(2))) dispersions were measured using an oxidation-reduction potential (ORP) electrode probe. The particles under testing differed in terms of their particle size and dispersion stability in deionised water and in various ecotox media. The ORP values of the various dispersions and how they fluctuate relative to each other are discussed. Results show that the ORP values are mainly governed by the type of liquid media employed, with little contributions from the nanoparticles. Seawater was shown to have reduced the ORP value, which was attributed to an increase in the concentration of reducing agents such as sulphites or the reduction of dissolved oxygen concentration. The lack of redox potential value contribution from the particles themselves is thought to be due to insufficient interaction of the particles at the Pt electrode of the ORP probe. PMID:22131988

  2. Tuning of redox regulatory mechanisms, reactive oxygen species and redox homeostasis under salinity stress

    Directory of Open Access Journals (Sweden)

    Hossain eSazzad

    2016-05-01

    Full Text Available Soil salinity is a crucial environmental constraint which limits biomass production at many sites on a global scale. Saline growth conditions cause osmotic and ionic imbalances, oxidative stress and perturb metabolism, e.g. the photosynthetic electron flow. The plant ability to tolerate salinity is determined by multiple biochemical and physiological mechanisms protecting cell functions, in particular by regulating proper water relations and maintaining ion homeostasis. Redox homeostasis is a fundamental cell property. Its regulation includes control of reactive oxygen species (ROS generation, sensing deviation from and readjustment of the cellular redox state. All these redox related functions have been recognized as decisive factors in salinity acclimation and adaptation. This review focuses on the core response of plants to overcome the challenges of salinity stress through regulation of ROS generation and detoxification systems and to maintain redox homeostasis. Emphasis is given to the role of NADH oxidase (RBOH, alternative oxidase (AOX, the plastid terminal oxidase (PTOX and the malate valve with the malate dehydrogenase isoforms under salt stress. Overwhelming evidence assigns an essential auxiliary function of ROS and redox homeostasis to salinity acclimation of plants.

  3. Crossing redox boundaries--aquifer redox history and effects on iron mineralogy and arsenic availability.

    Science.gov (United States)

    Banning, Andre; Rüde, Thomas R; Dölling, Bettina

    2013-11-15

    Cretaceous shallow marine sediments from northwestern Germany exhibit a distinct colour and geochemical boundary in a depth of several decametres, witnessing a terrestrial oxidative paleo redox process which resulted in cement loss and oxidation of Fe(II) phases. Sediment samples were obtained from boreholes drilled in near-coastal and further basinward paleo environments, including both reduced and oxidized redox facies, to characterize As and Fe occurrence in unaltered layers and redistributional consequences of the redox event. Geochemical and mineralogical composition and As fractionation were assessed. Arsenic resides in pyrite in the reduced section with a bulk rock maximum concentration of 39 μg g(-1), calculated Aspyrite is ~0.2 wt.%. Siderite concretions in the fine sands do not function as As sinks, neither does glauconite whose general As/Fe leaching behaviour was characterized. In the zone of redox transition, reduced and oxidized phases coexist and elevated As concentrations (up to 73 μg g(-1)) with high proportions of reactive As were detected. Arsenic behaviour changes from relatively homogeneous Fe sulphide-control in the unaltered sediments to very heterogeneous Fe hydroxide-control above the paleo redox boundary. The studied characteristics determine recent As availability in the subsurface and must be considered during groundwater extraction from this highly important aquifer. PMID:23280400

  4. Redox Enzymes of Red Beetroot Vacuoles (Beta vulgaris L.

    Directory of Open Access Journals (Sweden)

    E.V. Pradedova

    2014-12-01

    Full Text Available Years of research have shown that some of the redox elements (enzymes, coenzymes, and co-substrate are isolated from each other kinetic and spatial manner (compartmentalization in the eukaryotic cells. The redox elements forming the "highly" and "widely" specialized redox system are found in all cell structures: mitochondria, plastids, peroxisomes, apoplast, nucleus etc. In recent years the active involvement of the central vacuole in the maintenance of the plant cell redox homeostasis is discussed, actually the information about the vacuolar redox system is very small. The high-priority redox processes and "redox-specialization" of the vacuolar compartment are not known. We have begun a study of red beet-root vacuole redox systems (Beta vulgaris L. and have identified redox enzymes such as: phenol peroxidase (EC 1.11.1.7, superoxide dismutase (EC 1.15.1.1 and glutathione reductase (EC 1.8.1.7. This paper presents some of the characteristics of these enzymes and considers the probable ways of their functioning in vacuolar redox chains.

  5. Characterisation of the Redox Sensitive NMDA Receptor

    KAUST Repository

    Alzahrani, Ohood

    2016-05-01

    Glucose entry into the brain and its subsequent metabolism to L-lactate, regulated by astrocytes, plays a major role in synaptic plasticity and memory formation. A recent study has shown that L-lactate produced by the brain upon stimulation of glycolysis, and glycogen-derived L-lactate from astrocytes and its transport into neurons, is crucial for memory formation. A recent study revealed the molecular mechanisms that underlie the role of L-lactate in neuronal plasticity and long-term memory formation. L-lactate was shown to induce a cascade of molecular events via modulation of redox-sensitive N-Methyl-D-aspartate (NMDA) receptor activity that was mimicked by nicotinamide adenine dinucleotide hydride (NADH) co-enzyme. This indicated that changes in cellular redox state, following L-lactate transport inside the cells and its subsequent metabolism, production of NADH, and favouring a reduced state are the key effects of L-lactate. Therefore, we are investigating the role of L-lactate in modulating NMDA receptor function via redox modulatory sites. Accordingly, crucial redox-sensitive cysteine residues, Cys320 and Cys87, of the NR2A NMDA receptor subunit are mutated using site-directed mutation, transfected, and expressed in HEK293 cells. This cellular system will then be used to characterise and monitor its activity upon Llactate stimulation, compared to the wild type. This will be achieved by calcium imaging, using fluorescent microscopy. Our data shows that L-lactate potentiated NMDA receptor activity and increased intracellular calcium influx in NR1/NR2A wild type compared to the control condition (WT NR1/NR2A perfused with (1μM) glutamate and (1μM) glycine agonist only), showing faster response initiation and slower decay rate of the calcium signal to the baseline. Additionally, stimulating with L-lactate associated with greater numbers of cells having high fluorescent intensity (peak amplitude) compared to the control. Furthermore, L-lactate rescued the

  6. Redox environment effect on redox sensitive elements in surface sediments of the Changjiang Estuary hypoxia zone

    Institute of Scientific and Technical Information of China (English)

    Shumei XU; Shikui ZHAI; Aibin ZHANG; Huaijing ZHANG; Haijian LU

    2008-01-01

    The grain size and element (including redox sensitive elements and terrigenous elements) concentration of surface sediments from the Changjiang Estuary hypoxia zone and its adjacent sea area were measured in this research.Based on the obtained data,the hypoxic environment's influence on the distribution of elements in surface sediments was further studied.We believe that the "redox environment effect" greatly influences the distribution of the RSE,which reveals the "patchy enrichment pattern" offshore in the hypoxia zone,while the distribution of the terrigenous elements which shows the "stripped enrichment pattern" near shore is mainly affected by "granularity effects".Due to the existence of the hypoxia zone of the Changjiang Estuary,the distribution of the RSE such as Mo,Cd and V in the study area exhibits the characteristics of "redox environment effects".

  7. Reengineering redox sensitive GFP to measure mycothiol redox potential of Mycobacterium tuberculosis during infection.

    Science.gov (United States)

    Bhaskar, Ashima; Chawla, Manbeena; Mehta, Mansi; Parikh, Pankti; Chandra, Pallavi; Bhave, Devayani; Kumar, Dhiraj; Carroll, Kate S; Singh, Amit

    2014-01-01

    Mycobacterium tuberculosis (Mtb) survives under oxidatively hostile environments encountered inside host phagocytes. To protect itself from oxidative stress, Mtb produces millimolar concentrations of mycothiol (MSH), which functions as a major cytoplasmic redox buffer. Here, we introduce a novel system for real-time imaging of mycothiol redox potential (EMSH ) within Mtb cells during infection. We demonstrate that coupling of Mtb MSH-dependent oxidoreductase (mycoredoxin-1; Mrx1) to redox-sensitive GFP (roGFP2; Mrx1-roGFP2) allowed measurement of dynamic changes in intramycobacterial EMSH with unprecedented sensitivity and specificity. Using Mrx1-roGFP2, we report the first quantitative measurements of EMSH in diverse mycobacterial species, genetic mutants, and drug-resistant patient isolates. These cellular studies reveal, for the first time, that the environment inside macrophages and sub-vacuolar compartments induces heterogeneity in EMSH of the Mtb population. Further application of this new biosensor demonstrates that treatment of Mtb infected macrophage with anti-tuberculosis (TB) drugs induces oxidative shift in EMSH , suggesting that the intramacrophage milieu and antibiotics cooperatively disrupt the MSH homeostasis to exert efficient Mtb killing. Lastly, we analyze the membrane integrity of Mtb cells with varied EMSH during infection and show that subpopulation with higher EMSH are susceptible to clinically relevant antibiotics, whereas lower EMSH promotes antibiotic tolerance. Together, these data suggest the importance of MSH redox signaling in modulating mycobacterial survival following treatment with anti-TB drugs. We anticipate that Mrx1-roGFP2 will be a major contributor to our understanding of redox biology of Mtb and will lead to novel strategies to target redox metabolism for controlling Mtb persistence. PMID:24497832

  8. Dynamic Terahertz Beam Steering Based on Graphene Metasurfaces

    CERN Document Server

    Liu, Liming; Hattori, Haroldo T

    2016-01-01

    A full (2$\\pi$) phase modulation is critical for efficient wavefront manipulation. In this article, we propose a metasurface based on graphene long/short-strip resonators which are capable of implementing a dynamic 2$\\pi$ phase modulation by applying different voltages to different graphene resonators. The configuration is found to have high reflection efficiency (minimum 56%) and has a full phase modulation in a wide frequency range. Terahertz (THz) beam steering as large as 120 degrees ($\\pm60^\\circ$) is demonstrated in a broad frequency range (1.2 to 1.9 THz) by changing the Fermi levels of different graphene resonators accordingly. This metasurface can provide a new platform for effectively manipulating THz waves.

  9. Acoustic Prism for Continuous Beam Steering Based on Piezoelectric Metamaterial

    CERN Document Server

    Xu, Jiawen

    2016-01-01

    This paper investigates an acoustic prism for continuous acoustic beam steering by a simple frequency sweep. This idea takes advantages of acoustic wave velocity shifting in metamaterials in the vicinity of local resonance. We apply this concept into the piezoelectric metamaterial consisting of host medium and piezoelectric LC shunt. Theoretical modeling and FEM simulations are carried out. It is shown that the phase velocity of acoustic wave changes dramatically in the vicinity of local resonance. The directions of acoustic wave can be adjusted continuously between 2 to 16 degrees by a simple sweep of the excitation frequency. Such an electro-mechanical coupling system has a feature of adjusting local resonance without altering the mechanical part of the system.

  10. Sugar transport across lactose permease probed by steered molecular dynamics

    DEFF Research Database (Denmark)

    Jensen, Morten Østergaard; Yin, Ying; Tajkhorshid, Emad;

    2007-01-01

    Escherichia coli lactose permease (LacY) transports sugar across the inner membrane of the bacterium using the proton motive force to accumulate sugar in the cytosol. We have probed lactose conduction across LacY using steered molecular dynamics, permitting us to follow molecular and energetic......, forcing it to interact with channel lining residues. Lactose forms a multitude of direct sugar-channel hydrogen bonds, predominantly with residues of the flexible N-domain, which is known to contribute a major part of LacY's affinity for lactose. In the periplasmic half-channel lactose predominantly......-sugar interaction maximal. Upon unbinding from the binding pocket, lactose undergoes a rotation to permeate either half-channel with its long axis aligned parallel to the channel axis. The results hint at the possibility of a transport mechanism, in which lactose permeates LacY through a narrow periplasmic half...

  11. Steering optical comb frequency by rotating polarization state

    CERN Document Server

    Zhang, Y; Zhang, X F; Zhang, L; Han, W; Guo, W; Jiang, H; Zhang, S

    2016-01-01

    Optical frequency combs, with precise control of repetition rate and carrier-envelope-offset frequency, have revolutionized many fields, such as fine optical spectroscopy, optical frequency standards, ultra-fast science research, ultra-stable microwave generation and precise ranging measurement. However, existing high bandwidth frequency control methods have small dynamic range, requiring complex hybrid control techniques. To overcome this limitation, we develop a new approach, where a home-made intra-cavity electro-optic modulator tunes polarization state of laser signal rather than only optical length of the cavity, to steer frequencies of a nonlinear-polarization-rotation mode-locked laser. By taking advantage of birefringence of the whole cavity, this approach results in not only broadband but also relative large-dynamic frequency control. Experimental results show that frequency control dynamic range increase at least one order in comparison with the traditional intra-cavity electro-optic modulator techn...

  12. Steered molecular dynamics simulations of protein-ligand interactions

    Institute of Scientific and Technical Information of China (English)

    XU Yechun; SHEN Jianhua; LUO Xiaomin; SHEN Xu; CHEN Kaixian; JIANG Hualiang

    2004-01-01

    Studies of protein-ligand interactions are helpful to elucidating the mechanisms of ligands, providing clues for rational drug design. The currently developed steered molecular dynamics (SMD) is a complementary approach to experimental techniques in investigating the biochemical processes occurring at microsecond or second time scale, thus SMD may provide dynamical and kinetic processes of ligand-receptor binding and unbinding, which cannot be accessed by the experimental methods. In this article, the methodology of SMD is described, and the applications of SMD simulations for obtaining dynamic insights into protein-ligand interactions are illustrated through two of our own examples. One is associated with the simulations of binding and unbinding processes between huperzine A and acetylcholinesterase, and the other is concerned with the unbinding process of α-APA from HIV-1 reverse transcriptase.

  13. Lightweight computational steering of very large scale molecular dynamics simulations

    International Nuclear Information System (INIS)

    We present a computational steering approach for controlling, analyzing, and visualizing very large scale molecular dynamics simulations involving tens to hundreds of millions of atoms. Our approach relies on extensible scripting languages and an easy to use tool for building extensions and modules. The system is extremely easy to modify, works with existing C code, is memory efficient, and can be used from inexpensive workstations and networks. We demonstrate how we have used this system to manipulate data from production MD simulations involving as many as 104 million atoms running on the CM-5 and Cray T3D. We also show how this approach can be used to build systems that integrate common scripting languages (including Tcl/Tk, Perl, and Python), simulation code, user extensions, and commercial data analysis packages

  14. Beam steering and impedance matching of plasmonic horn nanoantennas

    CERN Document Server

    Afridi, Adeel

    2016-01-01

    In this paper, we study a plasmonic horn nanoantenna on a metal-backed substrate. The horn nanoantenna structure consists of a two-wire transmission line (TWTL) flared at the end. We analyze the effect of the substrate thickness on the nanoantenna's radiation pattern, and demonstrate beam steering in a broad range of elevation angles. Furthermore, we analyze the effect of the ground plane on the impedance matching between the antenna and the TWTL, and observe that the ground plane increases the back reflection into the waveguide. To reduce the reflection, we develop a transmission line model to design an impedance matching section which leads to 99.75% power transmission to the nanoantenna.

  15. Energetic and climatic consequences of promotional levies and steering

    International Nuclear Information System (INIS)

    This report for the Swiss Federal Office of Energy (SFOE) presents the results of a study made in connection with a proposed levy on non-renewable energy sources that was to be used to promote the use of renewable forms of energy and energy-efficiency. A further steering-tax on non-renewable forms of energy is also the subject of the study. The report examines the framework, as defined by energy legislation, for the implementation of such taxes and their possible impact on energy prices. The usage and substitution potentials of the various renewable forms of energy and of efficiency technologies are estimated. Suggestions for the distribution of the promotional funds on the basis of non-amortisable costs incurred by the use of the renewable technologies are discussed. The effect of the two levies on energy consumption and carbon dioxide emissions are discussed and illustrated with graphical representations of various development scenarios

  16. Planning analysis and political steering with New Public Management

    DEFF Research Database (Denmark)

    Sager, Tore Øivin; Sørensen, Claus Hedegaard

    2011-01-01

    Interviews with members of the Norwegian national assembly’s Standing Committee for Transport and Communications were conducted in 1995, 1997, 2001, and 2004. The politicians were asked about the usefulness of analytic input that planners contribute to national plans, first the Norwegian Road and...... by the Government. The political concentration on strategic steering, the concomitant delegation, and management by objectives and results are central components of New Public Management....... of interviews sheds light on the apparent paradox that parliamentarians accept delegation of highway investment decisions despite their profound scepticism to the cost-benefit analyses and impact calculations that are essential to management by objectives and results, which was to give them continued political...... control despite delegation. Another conundrum is the parliamentarians’ willingness to renounce the right to decide over most highway projects, even if these were seen as politically important, in order to obtain a strategic overview which they have been unable to use for changing the priorities set...

  17. Structural Assessment of Advanced Composite Tow-Steered Shells

    Science.gov (United States)

    Wu, K. Chauncey; Stanford, Bret K.; Hrinda, Glenn A.; Wang, Zhuosong; Martin, Robert a.; Kim, H. Alicia

    2013-01-01

    The structural performance of two advanced composite tow-steered shells, manufactured using a fiber placement system, is assessed using both experimental and analytical methods. The fiber orientation angles vary continuously around the shell circumference from 10 degrees on the shell crown and keel, to 45 degrees on the shell sides. The two shells differ in that one shell has the full 24-tow course applied during each pass of the fiber placement system, while the second shell uses the fiber placement system s tow drop/add capability to achieve a more uniform shell wall thickness. The shells are tested in axial compression, and estimates of their prebuckling axial stiffnesses and bifurcation buckling loads are predicted using linear finite element analyses. These preliminary predictions compare well with the test results, with an average agreement of approximately 10 percent.

  18. Steering continuum electron dynamics by low-energy attosecond streaking

    Science.gov (United States)

    Geng, Ji-Wei; Xiong, Wei-Hao; Xiao, Xiang-Ru; Gong, Qihuang; Peng, Liang-You

    2016-08-01

    A semiclassical model is developed to understand the electronic dynamics in the low-energy attosecond streaking. Under a relatively strong infrared (IR) pulse, the low-energy part of photoelectrons initialized by a single attosecond pulse (SAP) can either rescatter with the ionic core and induce interferences structures in the momentum spectra of the ionized electrons or be recaptured into the Rydberg states. The Coulomb potential plays essential roles in both the electron rescattering and recapturing processes. We find that by changing the time delay between the SAP and the IR pulse, the photoelectrons yield or the population of the Rydberg states can be effectively controlled. The present study demonstrates a fascinating way to steer the electron motion in the continuum.

  19. Nanostructured Electrocatalysts for All-Vanadium Redox Flow Batteries.

    Science.gov (United States)

    Park, Minjoon; Ryu, Jaechan; Cho, Jaephil

    2015-10-01

    Vanadium redox reactions have been considered as a key factor affecting the energy efficiency of the all-vanadium redox flow batteries (VRFBs). This redox reaction determines the reaction kinetics of whole cells. However, poor kinetic reversibility and catalytic activity towards the V(2+)/V(3+) and VO(2+)/VO2(+) redox couples on the commonly used carbon substrate limit broader applications of VRFBs. Consequently, modified carbon substrates have been extensively investigated to improve vanadium redox reactions. In this Focus Review, recent progress on metal- and carbon-based nanomaterials as an electrocatalyst for VRFBs is discussed in detail, without the intention to provide a comprehensive review on the whole components of the system. Instead, the focus is mainly placed on the redox chemistry of vanadium ions at a surface of various metals, different dimensional carbons, nitrogen-doped carbon nanostructures, and metal-carbon composites. PMID:25899910

  20. Organic non-aqueous cation-based redox flow batteries

    Energy Technology Data Exchange (ETDEWEB)

    Jansen, Andrew N.; Vaughey, John T.; Chen, Zonghai; Zhang, Lu; Brushett, Fikile R.

    2016-03-29

    The present invention provides a non-aqueous redox flow battery comprising a negative electrode immersed in a non-aqueous liquid negative electrolyte, a positive electrode immersed in a non-aqueous liquid positive electrolyte, and a cation-permeable separator (e.g., a porous membrane, film, sheet, or panel) between the negative electrolyte from the positive electrolyte. During charging and discharging, the electrolytes are circulated over their respective electrodes. The electrolytes each comprise an electrolyte salt (e.g., a lithium or sodium salt), a transition-metal free redox reactant, and optionally an electrochemically stable organic solvent. Each redox reactant is selected from an organic compound comprising a conjugated unsaturated moiety, a boron cluster compound, and a combination thereof. The organic redox reactant of the positive electrolyte is selected to have a higher redox potential than the redox reactant of the negative electrolyte.

  1. Characterization of redox conditions in groundwater contaminant plumes

    DEFF Research Database (Denmark)

    Christensen, Thomas Højlund; Bjerg, Poul Løgstrup; Banwarth, Steven A.; Jakobsen, Rasmus; Heron, Gorm; Albrechtsen, Hans-Jørgen

    Evaluation of redox conditions in groundwater pollution plumes is often a prerequisite for understanding the behaviour of the pollutants in the plume and for selecting remediation approaches. Measuring of redox conditions in pollution plumes is, however, a fairly recent issue and yet relative few...... cases have been reported. No standardised or generally accepted approach exists. Slow electrode kinetics and the common lack of internal equilibrium of redox processes in pollution plumes make, with a few exceptions, direct electrochemical measurement and rigorous interpretation of redox potentials...... dubious, if not erroneous. Several other approaches have been used in addressing redox conditions in pollution plumes: redox-sensitive compounds in groundwater samples, hydrogen concentrations in groundwater, concentrations of volatile fatty acids in groundwater, sediment characteristics and microbial...

  2. Effects of programmed gain strategies on performance and carcass characteristics of steers.

    Science.gov (United States)

    Knoblich, H V; Fluharty, F L; Loerch, S C

    1997-12-01

    In Trial 1, 161 Angus x Simmental crossbred steers (initial BW 305 +/- 1.0 kg) were used in a completely randomized design experiment to determine the effects of intake restriction and programmed gain on cattle performance and carcass composition and characteristics. Five feeding systems were tested using step-wise increases in programmed intake level. Initially steers were fed to gain 1.13 kg/d. Intake was then increased to achieve a gain of 1.36 kg/d. At the end of the feeding period, steers had ad libitum access to feed. Duration of intake restriction and the period of unrestricted intake was varied. Feeding steers at restricted intakes and then increasing daily gain by increasing feed intake using four different schedules all reduced (P .10) quality grade of the carcasses. In Trial 2, 77 individually penned Angus x Simmental crossbred steers (initial BW 273 +/- 1.2 kg) were used to determine the effects of various feed intake restriction systems. For systems 1 through 4, multiple periods of restriction and realimentation were investigated; the duration and magnitude of restriction were varied. Feed intake was not restricted for steers in system 5. The feed restriction systems used in this experiment did not result in decreased total feed intake or changes in carcass composition as compared with offering ad libitum access to feed. Reducing total energy intake seems to be a prerequisite to altering feed efficiency of steers in limit-feeding systems. PMID:9419981

  3. Performance on steering power ratio of tracked vehicles influenced by soil parameters

    Directory of Open Access Journals (Sweden)

    Chi Yuan

    2015-01-01

    Full Text Available In order to study tracked vehicle adopting different steering mechanism, we use steering power ratio to evaluate its performance. The influencing factors of steering power ratio have been theoretically studied. And we designed the experimental prototype to test. We find that steering power ratio is related to vehicle parameters, resistance coefficient, turning radius, skid ratio, slip ratio and steering coefficient not only, but also it is related to soil parameters (including soil cohesion, internal friction angle of soil and shear modulus of soil. On the condition that vehicle parameters and resistance coefficient are determined, the soil shear tests were carried out, which acquired that the average moisture content of soil is 16.85%,soil cohesion is 14.071 Kpa, internal friction angle of soil is 17.93°, and shear modulus of soil is 0.00027 m. Through being researched, steering power ratio is related to turning radius, skid ratio and slip ratio, which has the important significance on the study of steering power ratio.

  4. Ultrafast beam steering using gradient Au-Ge₂Sb₂Te₅-Au plasmonic resonators.

    Science.gov (United States)

    Cao, Tun; Zheng, Guangzhao; Wang, Shuai; Wei, Chenwei

    2015-07-13

    Beam steering devices have gained extensive interests in the fields of optical interconnects, communications, displays and data storages. However, the challenge lies in obtaining an ultrafast beam steering structure in the optical regime. Here, we propose phase-array-like plasmonic resonators based on metal/phase-change materials (PCMs)/metal trilayers for all-optical ultrafast beam steering in the mid-infrared (MIR) region. We numerically demonstrate an angle beam steering of 11° for transmitted wave (front lobe) and 22° for reflected wave (back lobe) by switching between the amorphous and crystalline states of the PCM (Ge₂Sb₂Te₅). A photothermal model is used to study the temporal variation of the temperature of the Ge₂Sb₂Te₅ film to show potential for switching the phase of Ge₂Sb₂Te₅ by optical heating. Generation of the beam steering in this structure exhibits a fast beam steering time of 3.6 ns under a low pump light intensity of 2.6 μW/μm₂. Our design possesses a simple geometry which can be fabricated using standard photolithography patterning and is essential for exploiting the ultrafast beam steering in various applications in the MIR regime. PMID:26191862

  5. Generalized Internal Model Robust Control for Active Front Steering Intervention

    Institute of Scientific and Technical Information of China (English)

    WU Jian; ZHAO Youqun; JI Xuewu; LIU Yahui; ZHANG Lipeng

    2015-01-01

    Because of the tire nonlinearity and vehicle’s parameters’ uncertainties, robust control methods based on the worst cases, such as H∞, μsynthesis, have been widely used in active front steering control, however, in order to guarantee the stability of active front steering system (AFS) controller, the robust control is at the cost of performance so that the robust controller is a little conservative and has low performance for AFS control. In this paper, a generalized internal model robust control (GIMC) that can overcome the contradiction between performance and stability is used in the AFS control. In GIMC, the Youla parameterization is used in an improved way. And GIMC controller includes two sections:a high performance controller designed for the nominal vehicle model and a robust controller compensating the vehicle parameters’ uncertainties and some external disturbances. Simulations of double lane change (DLC) maneuver and that of braking on split-μroad are conducted to compare the performance and stability of the GIMC control, the nominal performance PID controller and the H∞ controller. Simulation results show that the high nominal performance PID controller will be unstable under some extreme situations because of large vehicle’s parameters variations, H∞ controller is conservative so that the performance is a little low, and only the GIMC controller overcomes the contradiction between performance and robustness, which can both ensure the stability of the AFS controller and guarantee the high performance of the AFS controller. Therefore, the GIMC method proposed for AFS can overcome some disadvantages of control methods used by current AFS system, that is, can solve the instability of PID or LQP control methods and the low performance of the standard H∞controller.

  6. DSP-based electric power assisted steering using BLDC motor

    Indian Academy of Sciences (India)

    R Murugan; S Nandakumar; M S Mohiyadeen

    2008-10-01

    This paper introduces a design and implementation of electrically assisted power steering (EAS) using BLDC motor for a vehicle. The control architecture consists of two layers of control, namely the vehicle speed associated control and the torque assist control. In the higher level of control architecture, the vehicle speed controller works as an assistance level controller for the steering effort. In the lower level, the torque controller gives the effort level control. This has been realized by torque sensor and vehicle sensor interfaced in the DSP. For implementing in the system, a DSP-based BLDC motor controller with three-phase inverter module is specially designed using Hall-effect sensor feedback and a single dc-link current sensor. This work is implemented in a Light Commercial Vehicle having a recirculating ball type gear. This is for the first time (EAS) being implemented for this type of vehicle any where in the world. Generally, EAS having clutch to disconnect the motor in high speed or abnormal conditions from the gear box. In this implementation the motor is directly coupled to gearbox without clutch and all abnormalities are handled by the processor. This is implemented without modifying the vehicle supply system like changing the existing alternator or rating of the battery and using the existing sensors. The design is such a way that the feel of the driver assistance can be varied easily at any time. The performance of the control system is experimentally verified and it is tested in one of the Light Commercial Vehicle (LCV).

  7. Generalized internal model robust control for active front steering intervention

    Science.gov (United States)

    Wu, Jian; Zhao, Youqun; Ji, Xuewu; Liu, Yahui; Zhang, Lipeng

    2015-03-01

    Because of the tire nonlinearity and vehicle's parameters' uncertainties, robust control methods based on the worst cases, such as H ∞, µ synthesis, have been widely used in active front steering control, however, in order to guarantee the stability of active front steering system (AFS) controller, the robust control is at the cost of performance so that the robust controller is a little conservative and has low performance for AFS control. In this paper, a generalized internal model robust control (GIMC) that can overcome the contradiction between performance and stability is used in the AFS control. In GIMC, the Youla parameterization is used in an improved way. And GIMC controller includes two sections: a high performance controller designed for the nominal vehicle model and a robust controller compensating the vehicle parameters' uncertainties and some external disturbances. Simulations of double lane change (DLC) maneuver and that of braking on split- µ road are conducted to compare the performance and stability of the GIMC control, the nominal performance PID controller and the H ∞ controller. Simulation results show that the high nominal performance PID controller will be unstable under some extreme situations because of large vehicle's parameters variations, H ∞ controller is conservative so that the performance is a little low, and only the GIMC controller overcomes the contradiction between performance and robustness, which can both ensure the stability of the AFS controller and guarantee the high performance of the AFS controller. Therefore, the GIMC method proposed for AFS can overcome some disadvantages of control methods used by current AFS system, that is, can solve the instability of PID or LQP control methods and the low performance of the standard H ∞ controller.

  8. Redox homeostasis: The Golden Mean of healthy living

    Directory of Open Access Journals (Sweden)

    Fulvio Ursini

    2016-08-01

    Full Text Available The notion that electrophiles serve as messengers in cell signaling is now widely accepted. Nonetheless, major issues restrain acceptance of redox homeostasis and redox signaling as components of maintenance of a normal physiological steady state. The first is that redox signaling requires sudden switching on of oxidant production and bypassing of antioxidant mechanisms rather than a continuous process that, like other signaling mechanisms, can be smoothly turned up or down. The second is the misperception that reactions in redox signaling involve “reactive oxygen species” rather than reaction of specific electrophiles with specific protein thiolates. The third is that hormesis provides protection against oxidants by increasing cellular defense or repair mechanisms rather than by specifically addressing the offset of redox homeostasis. Instead, we propose that both oxidant and antioxidant signaling are main features of redox homeostasis. As the redox shift is rapidly reversed by feedback reactions, homeostasis is maintained by continuous signaling for production and elimination of electrophiles and nucleophiles. Redox homeostasis, which is the maintenance of nucleophilic tone, accounts for a healthy physiological steady state. Electrophiles and nucleophiles are not intrinsically harmful or protective, and redox homeostasis is an essential feature of both the response to challenges and subsequent feedback. While the balance between oxidants and nucleophiles is preserved in redox homeostasis, oxidative stress provokes the establishment of a new radically altered redox steady state. The popular belief that scavenging free radicals by antioxidants has a beneficial effect is wishful thinking. We propose, instead, that continuous feedback preserves nucleophilic tone and that this is supported by redox active nutritional phytochemicals. These nonessential compounds, by activating Nrf2, mimic the effect of endogenously produced electrophiles

  9. Redox homeostasis: The Golden Mean of healthy living.

    Science.gov (United States)

    Ursini, Fulvio; Maiorino, Matilde; Forman, Henry Jay

    2016-08-01

    The notion that electrophiles serve as messengers in cell signaling is now widely accepted. Nonetheless, major issues restrain acceptance of redox homeostasis and redox signaling as components of maintenance of a normal physiological steady state. The first is that redox signaling requires sudden switching on of oxidant production and bypassing of antioxidant mechanisms rather than a continuous process that, like other signaling mechanisms, can be smoothly turned up or down. The second is the misperception that reactions in redox signaling involve "reactive oxygen species" rather than reaction of specific electrophiles with specific protein thiolates. The third is that hormesis provides protection against oxidants by increasing cellular defense or repair mechanisms rather than by specifically addressing the offset of redox homeostasis. Instead, we propose that both oxidant and antioxidant signaling are main features of redox homeostasis. As the redox shift is rapidly reversed by feedback reactions, homeostasis is maintained by continuous signaling for production and elimination of electrophiles and nucleophiles. Redox homeostasis, which is the maintenance of nucleophilic tone, accounts for a healthy physiological steady state. Electrophiles and nucleophiles are not intrinsically harmful or protective, and redox homeostasis is an essential feature of both the response to challenges and subsequent feedback. While the balance between oxidants and nucleophiles is preserved in redox homeostasis, oxidative stress provokes the establishment of a new radically altered redox steady state. The popular belief that scavenging free radicals by antioxidants has a beneficial effect is wishful thinking. We propose, instead, that continuous feedback preserves nucleophilic tone and that this is supported by redox active nutritional phytochemicals. These nonessential compounds, by activating Nrf2, mimic the effect of endogenously produced electrophiles (parahormesis). In summary

  10. Electron transfer and interfacial behavior of redox proteins

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    This paper reviews the recent progress in the electron transfer and interfacial behavior of redox proteins. Significant achievements in the relevant fields are summarized including the direct electron transfer between proteins and electrodes, the thermodynamic and kinetic properties, catalytic activities and activity regulation of the redox proteins. It has been demonstrated that the electrochemical technique is an effective tool for protein studies, especially for probing into the electron transfer and interfacial behavior of redox proteins.

  11. Redox shuttles for safer lithium-ion batteries

    International Nuclear Information System (INIS)

    Overcharge protection is not only critical for preventing the thermal runaway of lithium-ion batteries during operation, but also important for automatic capacity balancing during battery manufacturing and repair. A redox shuttle is an electrolyte additive that can be used as intrinsic overcharge protection mechanism to enhance the safety characteristics of lithium-ion batteries. The advances on stable redox shuttles are briefly reviewed. Fundamental studies for designing stable redox shuttles are also discussed.

  12. Redox homeostasis: The Golden Mean of healthy living

    OpenAIRE

    Fulvio Ursini; Matilde Maiorino; Henry Jay Forman

    2016-01-01

    The notion that electrophiles serve as messengers in cell signaling is now widely accepted. Nonetheless, major issues restrain acceptance of redox homeostasis and redox signaling as components of maintenance of a normal physiological steady state. The first is that redox signaling requires sudden switching on of oxidant production and bypassing of antioxidant mechanisms rather than a continuous process that, like other signaling mechanisms, can be smoothly turned up or down. The second is the...

  13. DNA-mediated Charge Transport in Redox Sensing and Signaling

    OpenAIRE

    Genereux, Joseph C.; Boal, Amie K.; Barton, Jacqueline K.

    2010-01-01

    The transport of charge through the DNA base pair stack offers a route to carry out redox chemistry at a distance. Here we describe characteristics of this chemistry that have been elucidated and how this chemistry may be utilized within the cell. The shallow distance dependence associated with these redox reactions permits DNA-mediated signaling over long molecular distances in the genome and facilitates the activation of redox-sensitive transcription factors globally in response to oxidativ...

  14. Effect of weaning status and implant regimen on growth, performance, and carcass characteristics of steers.

    Science.gov (United States)

    Schoonmaker, J P; Fluharty, F L; Loerch, S C; Turner, T B; Moeller, S J; Wulf, D M

    2001-05-01

    One hundred forty-three Angus x Simmental crossbred steers (initial BW = 155.1 +/- 4.5 kg) were used in a 2-yr study (yr 1, n = 67; yr 2, n = 76) to determine the effects of weaning age, implant regimen, and the weaning age x implant regimen interaction on steer growth and performance, organ mass, carcass characteristics, and cooked beef palatability. Steers were early-weaned at an average age of 108 d (EW) or normally weaned at an average age of 202 d (NW) and allotted by weight to an aggressive or nonaggressive implant regimen. On their respective weaning dates, EW and NW steers were penned individually and fed a grain-based diet until they were slaughtered at a final BW of 546 kg. A subsample of steers (n = 2 per treatment) were slaughtered at 254 kg. At 254 kg, EW steers implanted with the aggressive implant regimen had 64% greater backfat depth than those implanted with the nonaggressive implant regimen; conversely, NW steers implanted with the aggressive implant regimen had 52% lower backfat depth than those implanted with the nonaggressive implant regimen (weaning status x implant regimen interaction; P 0.37) or feed efficiency (P > 0.15). Weaning status did not affect carcass characteristics (P > 0.14), final empty body composition (P > 0.25), or final longissimus muscle composition (P > 0.18); however, steaks from EW steers had higher (P 0.86) compared to the nonaggressive implant regimen. Placing early-weaned steers on an aggressive implant regimen is a viable management option. PMID:11374527

  15. Feedlot performance, carcass traits, and palatability traits of Hereford and Hereford x Brahman steers.

    Science.gov (United States)

    Sherbeck, J A; Tatum, J D; Field, T G; Morgan, J B; Smith, G C

    1995-12-01

    Short-yearling steer of known genotypes-straightbred Hereford (100H, n = 80) 75% Hereford x 25% Brahman (75H:25B, n = 80), and 50% Hereford x 50% Brahman (50H:50B, n = 80) were sampled serially at four time-on-feed endpoints (84, 98, 112, 126 d) to compare feedlot performance and carcass and palatability traits of Hereford and Hereford x Brahman steers. After slaughter, USDA yield grade and quality grade factors were recorded, and a portion of the longissimus muscle was removed from the left side of each carcass and fabricated into four 2.54-cm steaks for palatability analyses. Paired steaks from each carcass were aged (6 and 18 d after death), and sensory panel and shear force evaluations were performed. At a constant live weight, 100H steers had higher ADG and produced less mature carcasses with smaller longissimus muscle areas and higher marbling scores than did 75H:25B and 50H:50B steers. The 50H:50B steers had the highest (P Brahman breeding increased. EXtending the postmortem aging period from 6 to 18 d improved shear force values by 20% and panel tenderness ratings by approximately 14%. Beef from steers of the three breeds responded similarly to aging. When Certified Hereford Beef (CHB) specifications were applied, steaks from 100H steers and 75H:25B steers had similar shear force values, suggesting that beef from quarter-blood Brahman crossbred steers could be included in the CHB Program without detrimental effects on product tenderness. PMID:8655435

  16. Feedlot performance of Brahman x Angus versus Angus steers during cold weather.

    Science.gov (United States)

    Boyles, S L; Riley, J G

    1991-07-01

    Ten Angus and 10 Brahman x Angus F1 steers were used in a 184-d trial to compare feedlot performance during cold weather (-9 to 26 degrees C). Both groups of steers were exposed to the same environment for the same amount of time. All steers were fed for the same number of days regardless of frame score to avoid frame score x environment interactions. Brahman x Angus steers were 30.7 kg heavier (P less than .05) than Angus steers at the start of the trial. Differences in age (Brahman x Angus 40 d younger) for the two breed groups did not affect final live weight or carcass weight. Brahman x Angus steers consumed .2% less feed (P less than .05) as a percentage of BW than Angus steers; however, there was no difference in overall feed efficiency. Angus steers had a higher yield grade, more fat at the 12th rib (P less than .05), and graded 90% Choice; only 10% of the Brahman x Angus were graded Choice. Brahman x Angus steers were taller at the hip (P less than .05) and longer from first rib to aitch bone (P less than .05) and from thoracic vertebrae (T12/T13) to point of hock (P less than .05). Hide thickness determined at the neck, belly, and rump was found to be similar (7.7 mm) between the two groups. Sample hair weight and diameter did not differ between groups. Fiber, fat, protein, and DM digestibility coefficients were similar between groups but Brahman x Angus feces had a higher DM content.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:1885380

  17. Factors Controlling Redox Speciation of Plutonium and Neptunium in Extraction Separation Processes

    Energy Technology Data Exchange (ETDEWEB)

    Paulenova, Alena [Principal Investigator; Vandegrift, III, George F. [Collaborator

    2013-09-24

    The objective of the project was to examine the factors controlling redox speciation of plutonium and neptunium in UREX+ extraction in terms of redox potentials, redox mechanism, kinetics and thermodynamics. Researchers employed redox-speciation extractions schemes in parallel to the spectroscopic experiments. The resulting distribution of redox species w studied uring spectroscopic, electrochemical, and spectro-electrochemical methods. This work reulted in collection of data on redox stability and distribution of redox couples in the nitric acid/nitrate electrolyte and the development of redox buffers to stabilize the desired oxidation state of separated radionuclides. The effects of temperature and concentrations on the redox behavior of neptunium were evaluated.

  18. The Redox Potential of Hot Springs in Taiwan

    OpenAIRE

    Wen-Fu Chen and Menghau Sung

    2009-01-01

    Scientists began acquiring the basic of geology, occurrence, water temperature and chemistry of hot springs in Tai wan over a century ago. However, data regarding redox potential and important redox couples still remains limited. This study explores the redox status of hot springs in Taiwan by measuring Eh in the field and by determining the concentrations of commonly found redox couples, i.e., O2/H2O, NO3 -/NH4 +, and HS-/SO4 -2. Water samples were collected at hot spring discharge pools or ...

  19. Simulation and steering in the intertank matching section of the ground test accelerator

    International Nuclear Information System (INIS)

    The Intertank Matching Section (IMS) of the Ground Test Accelerator (GTA) is a short (36 cm) beamline designed to match the Radio Frequency Quadrupole (RFQ) exit beam into the first Drift Tube LINAC (DTL) tank. The IMS contains two steering quadrupoles (SMQs) and four variable-field focussing quads (VFQs). The SMQs are fixed strength permanent magnet quadrupoles on mechanical actuators capable of transverse movement for the purpose of steering the beam. The upstream and downstream steering quadrupoles are labelled SMQ1 and SMQ4 respectively. Also contained in the IMS are two RF cavities for longitudinal matching

  20. Giant and high-resolution beam steering using slow-light waveguide amplifier.

    Science.gov (United States)

    Gu, Xiaodong; Shimada, Toshikazu; Koyama, Fumio

    2011-11-01

    We propose a novel beam-steering device based on a slow-light waveguide amplifier. In this paper, we present the idea of this steering technique and show its modeling characteristics. Giant steering of the radiation beam is obtained by tuning the wavelength of input light, which is coupled into the Bragg reflector waveguide. A tunable deflection-angle range can be over 40 degrees. High beam coherency and flat intensity distribution enable us to obtain an ultra-large number of resolution-points over 1,000 for few-millimeter long devices. PMID:22109148

  1. Beam steering via resonance detuning in coherently coupled vertical cavity laser arrays

    International Nuclear Information System (INIS)

    Coherently coupled vertical-cavity surface-emitting laser arrays offer unique advantages for nonmechanical beam steering applications. We have applied dynamic coupled mode theory to show that the observed temporal phase shift between vertical-cavity surface-emitting array elements is caused by the detuning of their resonant wavelengths. Hence, a complete theoretical connection between the differential current injection into array elements and the beam steering direction has been established. It is found to be a fundamentally unique beam-steering mechanism with distinct advantages in efficiency, compactness, speed, and phase-sensitivity to current

  2. Companion-star beam steering of high-energy particles from Hercules X-1

    International Nuclear Information System (INIS)

    Gamma-ray emission from the X-ray pulsar Hercules X-1 is shown to be due to companion-star beam steering of high-energy particles from Hercules X-1. The authors demonstrate that the presence of even a weak dipole magnetic field around the companion star is sufficient to steer such a beam to a suitable target region for producing the observed γ-rays. The effects of such beam steering on γ-ray and neutrino observations is also discussed. (UK)

  3. Wearable Fabric Reconfigurable Beam-Steering Antenna for On/Off-Body Communication System

    OpenAIRE

    Seonghun Kang; Chang Won Jung

    2015-01-01

    This paper presents a comparison of on-body performances between omnidirectional (loop antenna) and reconfigurable beam-steering antennas. Both omnidirectional and reconfigurable antennas were manufactured on the same fabric substrate and operated at the frequency band of the WLAN 802.11a (5.725–5.85 GHz). The reconfigurable antenna was designed to steer the beam directions. In order to implement the beam-steering capability, the antenna used two PIN diodes. The maximum beam directions of thr...

  4. A new generation of IC based beam steering devices for free-space optical communication

    Science.gov (United States)

    Bedi, Vijit

    Free Space Optical (FSO) communication has tremendously advanced within the last decade to meet the ever increasing demand for higher communication bandwidth. Advancement in laser technology since its invention in the 1960's [1] attracted them to be the dominant source in FSO communication modules. The future of FSO systems lay in implementing semiconductor lasers due to their small size, power efficiency and mass fabrication abilities. In the near future, these systems are very likely to be used in space and ground based applications and revolutionary beam steering technologies will be required for distant communications in free-space. The highly directional characteristic inherent to a laser beam challenges and calls for new beam pointing and steering technologies for such type of communication. In this dissertation, research is done on a novel FSO communication device based on semiconductor lasers for high bandwidth communication. The "Fly eye transceiver" is an extremely wide steering bandwidth, completely non-mechanical FSO laser communication device primarily designed to replace traditional mechanical beam steering optical systems. This non-mechanical FSO device possesses a full spherical steering range and a very high tracking bandwidth. Inspired by the evolutionary model of a fly's eye, the full spherical steering range is assured by electronically controlled switching of its sub-eyes. Non mechanical technologies used in the past for beam steering such as acousto-optic Bragg cells, liquid crystal arrays or piezoelectric elements offer the wide steering bandwidth and fast response time, but are limited in their angular steering range. Mechanical gimbals offer a much greater steering range but face a much slower response time or steering bandwidth problem and often require intelligent adaptive controls with bulky driver amplifiers to feed their actuators. As a solution to feed both the fast and full spherical steering, the Fly-eye transceiver is studied as

  5. Chiral Redox-Active Isosceles Triangles.

    Science.gov (United States)

    Nalluri, Siva Krishna Mohan; Liu, Zhichang; Wu, Yilei; Hermann, Keith R; Samanta, Avik; Kim, Dong Jun; Krzyaniak, Matthew D; Wasielewski, Michael R; Stoddart, J Fraser

    2016-05-11

    Designing small-molecule organic redox-active materials, with potential applications in energy storage, has received considerable interest of late. Herein, we report on the synthesis, characterization, and application of two rigid chiral triangles, each of which consist of non-identical pyromellitic diimide (PMDI) and naphthalene diimide (NDI)-based redox-active units. (1)H and (13)C NMR spectroscopic investigations in solution confirm the lower symmetry (C2 point group) associated with these two isosceles triangles. Single-crystal X-ray diffraction analyses reveal their rigid triangular prism-like geometries. Unlike previously investigated equilateral triangle containing three identical NDI subunits, both isosceles triangles do not choose to form one-dimensional supramolecular nanotubes by dint of [C-H···O] interaction-driven columnar stacking. The rigid isosceles triangle, composed of one NDI and two PMDI subunits, forms-in the presence of N,N-dimethylformamide-two different types of intermolecular NDI-NDI and NDI-PMDI π-π stacked dimers with opposite helicities in the solid state. Cyclic voltammetry reveals that both isosceles triangles can accept reversibly up to six electrons. Continuous-wave electron paramagnetic resonance and electron-nuclear double-resonance spectroscopic investigations, supported by density functional theory calculations, on the single-electron reduced radical anions of the isosceles triangles confirm the selective sharing of unpaired electrons among adjacent redox-active NDI subunit(s) within both molecules. The isosceles triangles have been employed as electrode-active materials in organic rechargeable lithium-ion batteries. The evaluation of the structure-performance relationships of this series of diimide-based triangles reveals that the increase in the number of NDI subunits, replacing PMDI ones, within the molecules improves the electrochemical cell performance of the batteries. PMID:27070768

  6. Electronic Tongue Containing Redox and Conductivity Sensors

    Science.gov (United States)

    Buehler, Martin

    2007-01-01

    The Electronic Tongue (E-tongue 2) is an assembly of sensors for measuring concentrations of metal ions and possibly other contaminants in water. Potential uses for electronic tongues include monitoring the chemical quality of water in a variety of natural, industrial, and laboratory settings, and detecting micro-organisms indirectly by measuring microbially influenced corrosion. The device includes a heater, a temperature sensor, an oxidation/reduction (redox) sensor pair, an electrical sensor, an array of eight galvanic cells, and eight ion-specific electrodes.

  7. Fe-V redox flow batteries

    Science.gov (United States)

    Li, Liyu; Kim, Soowhan; Yang, Zhenguo; Wang, Wei; Zhang, Jianlu; Chen, Baowei; Nie, Zimin; Xia, Guanguang

    2014-07-08

    A redox flow battery having a supporting solution that includes Cl.sup.- anions is characterized by an anolyte having V.sup.2+ and V.sup.3+ in the supporting solution, a catholyte having Fe.sup.2+ and Fe.sup.3+ in the supporting solution, and a membrane separating the anolyte and the catholyte. The anolyte and catholyte can have V cations and Fe cations, respectively, or the anolyte and catholyte can each contain both V and Fe cations in a mixture. Furthermore, the supporting solution can contain a mixture of SO.sub.4.sup.2- and Cl.sup.- anions.

  8. Redox shuttles for lithium ion batteries

    Energy Technology Data Exchange (ETDEWEB)

    Weng, Wei; Zhang, Zhengcheng; Amine, Khalil

    2014-11-04

    Compounds may have general Formula IVA or IVB. ##STR00001## where, R.sup.8, R.sup.9, R.sup.10, and R.sup.11 are each independently selected from H, F, Cl, Br, CN, NO.sub.2, alkyl, haloalkyl, and alkoxy groups; X and Y are each independently O, S, N, or P; and Z' is a linkage between X and Y. Such compounds may be used as redox shuttles in electrolytes for use in electrochemical cells, batteries and electronic devices.

  9. Cancer Basics

    Science.gov (United States)

    ... Cancer? Breast Cancer Colon/Rectum Cancer Lung Cancer Prostate Cancer Skin Cancer Show All Cancer Types News and Features Cancer Glossary ACS Bookstore Cancer Information Cancer Basics Cancer Prevention & Detection Signs & Symptoms of Cancer Treatments & Side Effects ...

  10. Influence of breed and diet on growth, nutrient digestibility, body composition and plasma hormones of Brangus and Angus steers.

    Science.gov (United States)

    Beaver, E E; Williams, J E; Miller, S J; Hancock, D L; Hannah, S M; O'Connor, D L

    1989-09-01

    Two split-plot designed experiments were conducted to determine the effects of breed (Angus, A, or Brangus, B) and diet (fescue hay, FH; corn silage, CS; or concentrate) on composition and rate of growth, diet digestibility and plasma hormones of steers. In Exp. 1, 10 steers (five of each breed) were fed a CS-based diet followed by a FH-based diet for two consecutive 60-d periods. Both breeds had lower (P less than .01) DM intake and digestibility when fed FH than when fed CS diets. The B steers had higher (P less than .01) plasma insulin concentrations than A steers when fed the CS diet. In Exp. 2, during two consecutive years, 10 steers previously fed CS- and FH-based diets were finished with a corn silage-whole shelled corn-based diet. During yr 1, A steers had higher (P less than .01) DM intake and plasma triiodothyronine (T3) and thyroxine (T4) concentrations (P less than .05) than B steers did. Although final weights were similar (P greater than .10), A steers had heavier (P less than .05) carcass weights than B steers did. During yr 2, A steers had higher (P less than .07) DM and starch digestibilities and higher (P less than .01) plasma T4 concentrations than B steers did. The greater (P less than .01) energetic efficiency of A steers was attributed to the greater rates of fat deposition during yr 2. Regardless of type of diet fed, A steers were more efficient at depositing energy. Higher circulating T4 concentrations of A than B steers may explain some of the physiological differences between these breeds. PMID:2689419

  11. High-Performance Ferrite Nanoparticles through Nonaqueous Redox Phase Tuning.

    Science.gov (United States)

    Chen, Ritchie; Christiansen, Michael G; Sourakov, Alexandra; Mohr, Alan; Matsumoto, Yuri; Okada, Satoshi; Jasanoff, Alan; Anikeeva, Polina

    2016-02-10

    From magnetic resonance imaging to cancer hyperthermia and wireless control of cell signaling, ferrite nanoparticles produced by thermal decomposition methods are ubiquitous across biomedical applications. While well-established synthetic protocols allow for precise control over the size and shape of the magnetic nanoparticles, structural defects within seemingly single-crystalline materials contribute to variability in the reported magnetic properties. We found that stabilization of metastable wüstite in commonly used hydrocarbon solvents contributed to significant cation disorder, leading to nanoparticles with poor hyperthermic efficiencies and transverse relaxivities. By introducing aromatic ethers that undergo radical decomposition upon thermolysis, the electrochemical potential of the solvent environment was tuned to favor the ferrimagnetic phase. Structural and magnetic characterization identified hallmark features of nearly defect-free ferrite nanoparticles that could not be demonstrated through postsynthesis oxidation with nearly 500% increase in the specific loss powers and transverse relaxivity times compared to similarly sized nanoparticles containing defects. The improved crystallinity of the nanoparticles enabled rapid wireless control of intracellular calcium. Our work demonstrates that redox tuning during solvent thermolysis can generate potent theranostic agents through selective phase control in ferrites and can be extended to other transition metal oxides relevant to memory and electrochemical storage devices. PMID:26756463

  12. Alteration of the Redox State with Reactive Oxygen Species for 5-Fluorouracil-Induced Oral Mucositis in Hamsters

    OpenAIRE

    Yoshino, Fumihiko; Yoshida, Ayaka; Nakajima, Atsushi; Wada-Takahashi, Satoko; Takahashi, Shun-suke; Lee, Masaichi Chang-il

    2013-01-01

    Oral mucositis is often induced in patients receiving cancer chemotherapy treatment. It has been reported that oral mucositis can reduce quality of life, as well as increasing the incidence of mortality. The participation of reactive oxygen species (ROS) in the pathogenesis of oral mucositis is well known, but no report has actually demonstrated the presence of ROS. Thus, the purpose of this study was thus to demonstrate the involvement of ROS and the alteration of the redox state in oral muc...

  13. Dissolution of UO2 in redox conditions

    International Nuclear Information System (INIS)

    The performance assessment of the final disposal of the spent nuclear fuel in geological formations is strongly dependent on the spent fuel matrix dissolution. Unirradiated uranium (IV) dioxide has shown to be very useful for such purposes. The stability of UO2 is very dependent on vault redox conditions. At reducing conditions, which are expected in deep groundwaters, the dissolution of the UO2-matrix can be explained in terms of solubility, while under oxidizing conditions, the UO2 is thermodynamically unstable and the dissolution is kinetically controlled. In this report the parameters which affect the uranium solubility under reducing conditions, basically pH and redox potential are discussed. Under oxidizing conditions, UO2 dissolution rate equations as a function of pH, carbonate concentration and oxidant concentration are reported. Dissolution experiments performed with spent fuel are also reviewed. The experimental equations presented in this work, have been used to model independent dissolution experiments performed with both unirradiated and irradiated UO2. (Author)

  14. Redox characterization of functioning skeletal muscle

    Directory of Open Access Journals (Sweden)

    Li eZuo

    2015-11-01

    Full Text Available Skeletal muscle physiology is influenced by the presence of chemically reactive molecules such as reactive oxygen species (ROS. These molecules regulate multiple redox-sensitive signaling pathways that play a critical role in cellular processes including gene expression and protein modification. While ROS have gained much attention for their harmful effects in muscle fatigue and dysfunction, research has also shown ROS to facilitate muscle adaptation after stressors such as physical exercise. This manuscript aims to provide a comprehensive review of the current understanding of redox signaling in skeletal muscle. ROS-induced oxidative stress and its role in the aging process are discussed. Mitochondria have been shown to generate large amounts of ROS during muscular contractions, and thus are susceptible to oxidative stress. ROS can modify proteins located in the mitochondrial membrane leading to cell death and osmotic swelling. ROS also contribute to the necrosis and inflammation of muscle fibers that is associated with muscular diseases including Duchenne muscular dystrophy (DMD. It is imperative that future research continues to investigate the exact role of ROS in normal skeletal muscle function as well as muscular dysfunction and disease.

  15. Alterations in mitochondrial respiratory functions, redox metabolism and apoptosis by oxidant 4-hydroxynonenal and antioxidants curcumin and melatonin in PC12 cells

    International Nuclear Information System (INIS)

    Cellular oxidative stress and alterations in redox metabolisms have been implicated in the etiology and pathology of many diseases including cancer. Antioxidant treatments have been proven beneficial in controlling these diseases. We have recently shown that 4-hydroxynonenal (4-HNE), a by-product of lipid peroxidation, induces oxidative stress in PC12 cells by compromising the mitochondrial redox metabolism. In this study, we have further investigated the deleterious effects of 4-HNE on mitochondrial respiratory functions and apoptosis using the same cell line. In addition, we have also compared the effects of two antioxidants, curcumin and melatonin, used as chemopreventive agents, on mitochondrial redox metabolism and respiratory functions in these cells. 4-HNE treatment has been shown to cause a reduction in glutathione (GSH) pool, an increase in reactive oxygen species (ROS), protein carbonylation and apoptosis. A marked inhibition in the activities of the mitochondrial respiratory enzymes, cytochrome c oxidase and aconitase was observed after 4-HNE treatment. Increased nuclear translocation of NF-kB/p65 protein was also observed after 4-HNE treatment. Curcumin and melatonin treatments, on the other hand, maintained the mitochondrial redox and respiratory functions without a marked effect on ROS production and cell viability. These results suggest that 4-HNE-induced cytotoxicity may be associated, at least in part, with the altered mitochondrial redox and respiratory functions. The alterations in mitochondrial energy metabolism and redox functions may therefore be critical in determining the difference between cell death and survival

  16. Temporal steering and security of quantum key distribution with mutually unbiased bases against individual attacks

    Science.gov (United States)

    Bartkiewicz, Karol; Černoch, Antonín; Lemr, Karel; Miranowicz, Adam; Nori, Franco

    2016-06-01

    Temporal steering, which is a temporal analog of Einstein-Podolsky-Rosen steering, refers to temporal quantum correlations between the initial and final state of a quantum system. Our analysis of temporal steering inequalities in relation to the average quantum bit error rates reveals the interplay between temporal steering and quantum cloning, which guarantees the security of quantum key distribution based on mutually unbiased bases against individual attacks. The key distributions analyzed here include the Bennett-Brassard 1984 protocol and the six-state 1998 protocol by Bruss. Moreover, we define a temporal steerable weight, which enables us to identify a kind of monogamy of temporal correlation that is essential to quantum cryptography and useful for analyzing various scenarios of quantum causality.

  17. All-Optical Generation and Steering of Spatial Solitons in Discrete Waveguide Array

    OpenAIRE

    Merchant, Clark A.; Mel'nikov, Igor V.; Aitchison, J. Stewart

    2005-01-01

    We numerically study Stokes beam generation in an array of discrete waveguides. The feasibility of generation and steering of spatial solitons due to nonlinear Raman response is demonstrated for the first time

  18. National Status and Trends: Bioeffects Program - St. Thomas East End Reserves (STEER) Database

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The purpose of this effort was to characterize the extent and magnitude of chemical contamination in the St. Thomas East End Reserves or STEER, as part of a larger...

  19. A comparison of CMG steering laws for High Energy Astronomy Observatories (HEAOs)

    Science.gov (United States)

    Davis, B. G.

    1972-01-01

    A comparison of six selected control moment gyro steering laws for use on the HEAO spacecraft is reported. Basic equations are developed to project the momentum and torque of four skewed, single gimbal CMGs into vehicle coordinates. In response to the spacecraft attitude error signal, six algorithms are derived for controlling the CMG gimbal movements. HEAO performance data are obtained using each steering law and compared on the basis of such factors as accuracy, complexity, singularities, gyro hang-up and failure adaption. Moreover, each law is simulated with and without a magnetic momentum management system. The performance of any steering law is enhanced by the magnetic system. Without magnetics, the gimbal angles get large and there are significant differences in steering law performances due to cross coupling and nonlinearities. The performance of the pseudo inverse law is recommended for HEAO.

  20. One-to-One Mapping between Steering and Joint Measurability Problems.

    Science.gov (United States)

    Uola, Roope; Budroni, Costantino; Gühne, Otfried; Pellonpää, Juha-Pekka

    2015-12-01

    Quantum steering refers to the possibility for Alice to remotely steer Bob's state by performing local measurements on her half of a bipartite system. Two necessary ingredients for steering are entanglement and incompatibility of Alice's measurements. In particular, it is known that for the case of pure states of maximal Schmidt rank the problem of steerability for Bob's assemblage is equivalent to the problem of joint measurability for Alice's observables. We show that such an equivalence holds in general; namely, the steerability of any assemblage can always be formulated as a joint measurability problem, and vice versa. We use this connection to introduce steering inequalities from joint measurability criteria and develop quantifiers for the incompatibility of measurements. PMID:26684101

  1. Performance and carcass traits of early-weaned steers receiving either a pasture growing period or a finishing diet at weaning.

    Science.gov (United States)

    Myers, S E; Faulkner, D B; Nash, T G; Berger, L L; Parrett, D F; McKeith, F K

    1999-02-01

    A 2-yr study was conducted to evaluate 1) steers fed ad libitum high concentrate after weaning (CONC), or 2) steers grown on pasture for 82 d, followed by high-concentrate finishing (PAST), on the performance and carcass traits of 74 early-weaned (117 d of age) steers. Potential breed differences were evaluated using crossbred steers of three types: 1) 3/4 Angus x 1/4 Simmental (BRI), 2) 3/4 Simmental x 1/4 Angus (CON), and 3) 1/2 Wagyu x 1/4 Angus x 1/4 Simmental (WAG). Steers were randomly assigned within breed to the two treatments. There was no interactions (P > .10), so the data were pooled over years. The CONC steers had an ADG that was .17 kg/d higher (P = .0001), intake 1.09 kg/d lower (P = .0001), and gain:feed ratio .013 unit better (.190 vs .177, P = .008) than PAST steers overall. Growing treatment did not affect total concentrate consumed (P = .97). The BRI steers required 31 d less than did CON steers (P = .008), and 23 d less than WAG steers (P = .05) when fed to a constant fat end point (1.1 cm). The BRI steers exhibited an ADG .16 kg/d higher (P = .0003), tended (P = .07) to have an ADG intake .49 kg/d higher, and exhibited gain:feed .01 unit better (.189 vs 180) than WAG steers. When compared with CON steers, BRI steers consumed 310 kg less total concentrate (P = .0003). No differences (P > .38) were observed between growing treatments for carcass characteristics or sensory attributes except that CONC steers tended (P = .11) to improve percentage of steers grading Average Choice or higher by 47% over PAST steers. The WAG steers had a 76-unit higher marbling score (1,000 = Small00, 1,100 = Modest00) (P = .006) than BRI steers, resulting in 19% more (P = .09) steers grading > or = Choice and 82% more (P = .03) grading > or = Average Choice. Liver (P = .15) and rumen (P = .01) weights as a percentage of hot carcass weight were reduced for CONC steers. The CONC steers had higher gain, lower intake, better efficiency, reduced liver and rumen weights

  2. Cattle temperament influences metabolism: metabolic response to glucose tolerance and insulin sensitivity tests in beef steers.

    Science.gov (United States)

    Burdick Sanchez, N C; Carroll, J A; Broadway, P R; Hughes, H D; Roberts, S L; Richeson, J T; Schmidt, T B; Vann, R C

    2016-07-01

    Cattle temperament, defined as the reactivity of cattle to humans or novel environments, can greatly influence several physiological systems in the body, including immunity, stress, and most recently discovered, metabolism. Greater circulating concentrations of nonesterified fatty acids (NEFAs) found in temperamental cattle suggest that temperamental cattle are metabolically different than calm cattle. Further, elevated NEFA concentrations have been reported to influence insulin sensitivity. Therefore, the objective of this study was to determine whether cattle temperament would influence the metabolic response to a glucose tolerance test (GTT) and insulin sensitivity test (IST). Angus-cross steers (16 calm and 15 temperamental; 216 ± 6 kg BW) were selected based on temperament score measured at weaning. On day 1, steers were moved into indoor stanchions to allow measurement of individual ad libitum feed intake. On day 6, steers were fitted with indwelling rectal temperature probes and jugular catheters. At 9 AM on day 7, steers received the GTT (0.5-mL/kg BW of a 50% dextrose solution), and at 2 PM on day 7, steers received the IST (2.5 IU bovine insulin/kg BW). Blood samples were collected and serum isolated at -60, -45, -30, -15, 0, 10, 20, 30, 45, 60, 90, 120, and 150 min relative to each challenge. Serum was stored at -80°C until analyzed for cortisol, glucose, NEFA, and blood urea nitrogen concentrations. All variables changed over time (P < 0.01). For the duration of the study, temperamental steers maintained greater (P < 0.01) serum NEFA and less (P ≤ 0.01) serum blood urea nitrogen and insulin sensitivity (calculated using Revised Quantitative Insulin Sensitivity Check Index) compared with calm steers. During the GTT, temperamental steers had greater (P < 0.01) serum glucose, yet decreased (P = 0.03) serum insulin and (P < 0.01) serum insulin: serum glucose compared to calm cattle. During the IST, temperamental steers had greater (P < 0.01) serum

  3. Dynamic Steering for Improved Sensor Autonomy and Catalogue Maintenance

    Science.gov (United States)

    Hobson, T.; Gordon, N.; Clarkson, I.; Rutten, M.; Bessell, T.

    A number of international agencies endeavour to maintain catalogues of the man-made resident space objects (RSOs) currently orbiting the Earth. Such catalogues are primarily created to anticipate and avoid destructive collisions involving important space assets such as manned missions and active satellites. An agencys ability to achieve this objective is dependent on the accuracy, reliability and timeliness of the information used to update its catalogue. A primary means for gathering this information is by regularly making direct observations of the tens-of-thousands of currently detectable RSOs via networks of space surveillance sensors. But operational constraints sometimes prevent accurate and timely reacquisition of all known RSOs, which can cause them to become lost to the tracking system. Furthermore, when comprehensive acquisition of new objects does not occur, these objects, in addition to the lost RSOs, result in uncorrelated detections when next observed. Due to the rising number of space-missions and the introduction of newer, more capable space-sensors, the number of uncorrelated targets is at an all-time high. The process of differentiating uncorrelated detections caused by once-acquired now-lost RSOs from newly detected RSOs is a difficult and often labour intensive task. Current methods for overcoming this challenge focus on advancements in orbit propagation and object characterisation to improve prediction accuracy and target identification. In this paper, we describe a complementary approach that incorporates increased awareness of error and failed observations into the RSO tracking solution. Our methodology employs a technique called dynamic steering to improve the autonomy and capability of a space surveillance networks steerable sensors. By co-situating each sensor with a low-cost high-performance computer, the steerable sensor can quickly and intelligently decide how to steer itself. The sensor-system uses a dedicated parallel

  4. Effects of calf weaning age and subsequent management systems on growth performance and carcass characteristics of beef steers.

    Science.gov (United States)

    Moriel, P; Johnson, S E; Vendramini, J M B; McCann, M A; Gerrard, D E; Mercadante, V R G; Hersom, M J; Arthington, J D

    2014-08-01

    Brahman × British crossbred steers (n = 40 and 38 in yr 1 and 2, respectively) were used to evaluate the effects of calf management systems following early weaning (EW) on growth performance, muscle gene expression, and carcass characteristics. On the day of EW (d 0), steers were stratified by BW and age (95 ± 14 kg; 74 ± 14 d) and randomly assigned to a control treatment that was normally weaned (NW) on d 180 (n = 10 steers/yr) or to 1 of 3 EW treatments: 1) EW and limit fed a high-concentrate diet at 3.5% of BW (as-fed basis) in drylot until d 180 (EW180; n = 10 steers/yr), 2) EW and limit fed a high-concentrate diet at 3.5% of BW (as-fed basis) in drylot until d 90 and then grazed on bahiagrass pastures until d 180 (EW90; n = 10 steers/yr), or 3) EW and grazed on annual ryegrass pastures until d 60 (yr 1; n = 10 steers) or 90 (yr 2; n = 8 steers) and then on bahiagrass pastures until d 180 (EWRG). Early-weaned steers on ryegrass and bahiagrass pastures were supplemented with high-concentrate diet at 1.0% of BW (as-fed basis) until d 180. From d 180 to 270 (yr 1), all EW steers remained in their respective treatments, whereas NW steers were provided high-concentrate diet at 1.0% of BW (as-fed basis) on bahiagrass pastures. In yr 1, feedlot finishing period began on d 270. In yr 2, the study was terminated on d 180. In both years, EW180 steers were heaviest (P < 0.0001) on d 180. On d 180 of yr 1, EWRG steers were lightest (P < 0.0001) and EW90 steers were heavier (P = 0.05) than NW steers, whereas EW90, EWRG, and NW steers had similar BW on d 180 of yr 2 (P ≥ 0.14). On d 90, muscle PPARγ mRNA expression tended (P = 0.07) to be greater for EW180 steers and was greater (P = 0.008) for EW90 vs. EWRG steers but similar (P = 0.25) between EW180 and NW steers. On d 180, PPARγ mRNA was greater (P ≤ 0.06) for EW180 vs. NW, EW90, and EWRG steers. From d 274 to 302, EW180 steers had the least ADG (P ≤ 0.09), whereas EW90 steers had similar (P = 0.19) ADG

  5. Pitch ranking, electrode discrimination, and physiological spread of excitation using current steering in cochlear implants

    OpenAIRE

    Goehring, Jenny L.; Neff, Donna L.; Baudhuin, Jacquelyn L.; Hughes, Michelle L.

    2014-01-01

    The first objective of this study was to determine whether adaptive pitch-ranking and electrode-discrimination tasks with cochlear-implant (CI) recipients produce similar results for perceiving intermediate “virtual-channel” pitch percepts using current steering. Previous studies have not examined both behavioral tasks in the same subjects with current steering. A second objective was to determine whether a physiological metric of spatial separation using the electrically evoked compound acti...

  6. Integrated Driver and Active Steering Control for Vision-Based Lane Keeping

    OpenAIRE

    MARINO, Riccardo; Scalzi, Stefano; Netto, Mariana

    2012-01-01

    A nested PID steering control for autonomous vehicles equipped with artificial vision systems is designed so that the driver can override the automatic lane-keeping action and obtain a complete control of the vehicle lateral dynamics without any switching strategy. The control input is the steering wheel angle: it is designed on the basis of the yaw rate, which is measured by a gyroscope, and the lateral offset, which is measured by the vision system as the distance between the road centerlin...

  7. A Novel Millimeter-Wave Dual-Fed Phased Array for Beam Steering

    OpenAIRE

    Topak, Ali Eray

    2013-01-01

    In this dissertation, a novel beam steering approach is presented based on the superposition of two squinted antenna beams. The two antenna beams are realized by exciting the opposite feeds of a dual-fed array antenna. A change in the phase difference and amplitude ratio between the input signals, using only one phase shifter and two variable gain amplifiers or only two I-Q vector modulators, steers the main beam in different directions electronically.

  8. Initial investigation using statistical process control for quality control of accelerator beam steering

    OpenAIRE

    Able Charles M; Hampton Carnell J; Baydush Alan H; Munley Michael T

    2011-01-01

    Abstract Background This study seeks to increase clinical operational efficiency and accelerator beam consistency by retrospectively investigating the application of statistical process control (SPC) to linear accelerator beam steering parameters to determine the utility of such a methodology in detecting changes prior to equipment failure (interlocks actuated). Methods Steering coil currents (SCC) for the transverse and radial planes are set such that a reproducibly useful photon or electron...

  9. Driver Modelling: Two-Point- or Inverted Gaze-Beam-Steering

    OpenAIRE

    Möbus, Claus; Hübner, Stephan; GARBE, Hilke

    2007-01-01

    Modelling drivers’ behaviour is essential for developing error compensating assistance systems (Cacciabue, 2007). Salvucci (2007) recommends one of those, the Two-Point Visual Control Model of Steering (TPVCMOS; Salvucci & Gray, 2004), as the backbone of an integrated cognitive architecture. We discuss the shortcomings of this model from two standpoints: the empirical basis of human steering behaviour and a simulation study of a reconstructed TPVCMOS in the TORCS racing simulation environment...

  10. Demonstration of beam steering via dipole-coupled plasmonic spiral antenna

    OpenAIRE

    Guanghao Rui; Abeysinghe, Don C.; Nelson, Robert L.; Qiwen Zhan

    2013-01-01

    Optical antennas have been utilized to tailor the emission properties of nanoscale emitters in terms of the intensity, directivity and polarization. In this letter, we further explore the capability of beam steering via the use a spiral plasmonic structure as a transmitting antenna. According to both numerical simulation and experimental observations, the beaming direction can be steered through introducing a displacement of the feeding point to the spiral antenna from the geometrical center....

  11. Driver assistance system for lane departure avoidance by steering and differential braking

    OpenAIRE

    Minoiu-Enache, N.; Mammar, S.; GLASER, S; LUSETTI,B

    2010-01-01

    Lane departure avoidance systems assist actively the driver during inattention or drowsiness and increase driving safety. Most of the lane departure avoidance systems use for the lateral control of the vehicle in closed loop a DC motor similar to the electrical powered steering (EPS) assistance. Important difficulties and limits of this approach are the shared control with the driver on the steering wheel and the vehicle handling at limits. In this paper a combined lateral control using a DC ...

  12. A Steering Environment for Online Parallel Visualization of Legacy Parallel Simulations

    OpenAIRE

    Esnard, Aurélien; Richart, Nicolas; Coulaud, Olivier

    2006-01-01

    In the context of scientific computing, the computational steering consists in the coupling of numerical simulations with 3D visualization systems through the network. This allows scientists to monitor online the intermediate results of their computations in a more interactive way than the batch mode, and allows them to modify the simulation parameters on-the-fly. While most of existing computational steering environments support parallel simulations, they are often limited to sequential visu...

  13. Comparison of steering angle and bandwidth for various phased array antenna concepts

    Science.gov (United States)

    Bonjour, Romain; Singleton, Matthew; Leuchtmann, Pascal; Leuthold, Juerg

    2016-08-01

    In this paper we compare different integratable ultra-fast tunable true-time delay concepts with respect to their performances in a phased array system. The performances of the schemes are assessed with respect to the supported range, i.e. the range within which beam steering for a given fractional bandwidth can be achieved with a gain flatness better than 3 dB. We also compare the array gain as of function of steering angle and fractional bandwidth.

  14. The effect of supplementing rumen undegradable unsaturated fatty acids on marbling in early-weaned steers.

    Science.gov (United States)

    Mangrum, K S; Tuttle, G; Duckett, S K; Sell, G S; Krehbiel, C R; Long, N M

    2016-02-01

    The objective of this study was to determine if supplementation with a rumen undegradable unsaturated fatty acids (FA) source improved marbling deposition in early-weaned steers. All steers (Angus, = 23; Angus × Hereford, = 24) were weaned at 150 ± 5 d of age. Steers were blocked by BW and breed and then randomly assigned to either control (CON; average 1.5 kg of corn gluten feed [CGF], = 23) or isocaloric supplementation containing a rumen undegradable fat source (RUF; 200 g of Megalac-R added to an average of 1.06 kg of CGF, = 24) offered 5 d/wk for 110 d. All steers had ad libitum access to pastures throughout treatment and received supplements individually. Steer BW and blood samples were collected at 0, 55, and 110 d of supplementation, and real-time ultrasound measurements were collected at d 110. Following treatment, steers were transported to Oklahoma State University for finishing and subsequent harvesting at a commercial plant. All data were analyzed using the PROC MIXED procedure of SAS either as repeated measures or ANOVA depending on parameters. There were no significant changes in BW from the beginning of treatment to harvest due to treatment. Ultrasound data showed that RUF steers tended ( = 0.08) to have more i.m. fat than CON at d 110. Serum concentrations of FA showed a treatment × day interaction ( marbling scores than those of CON carcasses. All other carcass measures were similar between treatments. The percentage of total lipids was increased ( = 0.011) in steaks from RUF compared to CON. There was a decrease ( marbling deposition in early-weaned steers without impacting other carcass measures. PMID:27065154

  15. Loophole-free Einstein-Podolsky-Rosen experiment via quantum steering

    OpenAIRE

    Wittmann, Bernhard; Ramelow, Sven; Steinlechner, Fabian; Langford, Nathan K.; Brunner, Nicolas; Wiseman, Howard; Ursin, Rupert; Zeilinger, Anton

    2013-01-01

    Tests of the predictions of quantum mechanics for entangled systems have provided increasing evidence against local realistic theories. However, there still remains the crucial challenge of simultaneously closing all major loopholes - the locality, freedom-of-choice, and detection loopholes - in a single experiment. An important sub-class of local realistic theories can be tested with the concept of "steering". The term steering was introduced by Schr\\"odinger in 1935 for the fact that entang...

  16. Loophole-free Einstein-Podolsky-Rosen experiment via quantum steering

    OpenAIRE

    Wittmann, Bernhard; Ramelow, Sven; Steinlechner, Fabian; Langford, Nathan K.; Brunner, Nicolas; Wiseman, Howard; Ursin, Rupert; Zeilinger, Anton

    2011-01-01

    Tests of the predictions of quantum mechanics for entangled systems have provided increasing evidence against local realistic theories. However, there still remains the crucial challenge of simultaneously closing all major loopholes - the locality, freedom-of-choice, and detection loopholes - in a single experiment. An important sub-class of local realistic theories can be tested with the concept of "steering". The term steering was introduced by Schr\\"odinger in 1935 for the fact that entang...

  17. Correlations between meat quality and components of blood serum in steers fattened

    OpenAIRE

    Djagra, Ida Bagus; Wada, Hiroshi

    1980-01-01

    In fattened steers of Holstein breed correlation coefficients between factors of the carcass, and between roast grade and size of selected body parts were studied. Study of correlation between roast grade and levels of serumal components of blood taken at slaughter was carried out in the steer above mentioned. Roast grade had minus significant correlation to fat cover depth and daily gain, and plus significant correlation to hips width and thurls width. Correlations between roast grade and co...

  18. Evaluation of Meat Color and Physiochemical Characteristics in Forequarter Muscles of Holstein Steers

    OpenAIRE

    Moon, Sung Sil; Seong, Pil-Nam; Jeong, Jin Young

    2015-01-01

    The beef forequarter muscle comprises approximately 52% of carcass weight. The objective of this study was to evaluate the physiochemical characteristics and meat color from forequarter muscle of Holstein steers. Fifteen forequarter muscles were trimmed of external connective tissue and fat. An experimental group of eight Holstein steers was assessed using meat color, water-holding capacity, drip loss, and Warner–Bratzler shear force value at the same quality grade. The M. omotransversarius (...

  19. STEER AND HEIFER PRICE DIFFERENCES IN THE LIVE CATTLE AND CARCASS MARKETS

    OpenAIRE

    Schultz, Robert W.; Marsh, John M.

    1985-01-01

    A dynamic model is used to estimate quarterly price differences between steers and heifers in the feeder, slaughter, and carcass markets. For cattle within the same weight and grade range, their price differences are hypothesized to be influenced by seasonal, economic, and partly reflecting time changes in evaluation of steer and heifer quality in the live cattle and dressed meat trades. Stochastic factors are less prevalent at the feeder level, although risk of placing pregnant heifers in fe...

  20. Redox zones of a landfill leachate pollution plume (Vejen, Denmark)

    DEFF Research Database (Denmark)

    Lyngkilde, John; Christensen, Thomas Højlund

    1992-01-01

    , ferrogenic, nitrate-reducing and aerobic environments overa distance of 370 m. This redox zone sequence is consistent with thermodynamical principles and is closely matched by the leachate plume determined by the chloride plume distribution. The redox zone sequence is believed to be key in controlling the...... fate of reactive pollutants leached from the landfill....