WorldWideScience

Sample records for cancer program development

  1. Developing Effective Cancer Pain Education Programs

    OpenAIRE

    Martin, Michelle Y.; Pisu, Maria; Kvale, Elizabeth A.; Johns, Shelley A.

    2012-01-01

    Pain is prevalent, burdensome, and undertreated in individuals with cancer across the disease trajectory. Providing patients and family caregivers psychosocial support and education to manage cancer pain is a core component of quality care that can result in significant clinical benefit. In this review, we (1) outline an approach for developing and assessing the effectiveness of education programs for adults with cancer pain; (2) discuss considerations for tailoring programs to the needs of d...

  2. CT Lung Cancer Screening Program Development: Part 2.

    Science.gov (United States)

    Yates, Teri

    2015-01-01

    Radiology administrators must use innovative strategies around clinical collaboration and marketing to ensure that patients access the service in sufficient numbers. Radiology Associates of South Florida in collaboration with Baptist Health South Florida have developed a successful lung cancer screening program. The biggest factors in their success have been the affordability of their service and the quality of the program. Like mammography, lung cancer screening programs serve as an entry point to other services that generate revenue for the hospital. Patients may require further evaluation in the form of more imaging or surgical services for biopsy. Part 1 provided background and laid out fundamentals for starting a program. Part 2 focuses on building patient volume, marketing, and issues related to patient management after the screen is performed. PMID:26314180

  3. Development and evaluation of a support program for prostate cancer survivors in Alaska

    OpenAIRE

    Kelley, Stacy; DeCourtney, Christine; Thorsness, Julia

    2015-01-01

    Background. Prostate cancer survivors in Alaska and elsewhere have unmet support needs. The Men’s Prostate Cancer Survivorship Retreat, or “men’s retreat,” was developed targeting Alaska Native and non-Native men who were survivors of prostate cancer. The program brought together survivors in a supportive environment to discuss and share their experiences.Objective. Despite the proven effectiveness of support groups for improving quality of life for cancer patients, men typically do not parti...

  4. Common astrocytic programs during brain development, injury and cancer

    OpenAIRE

    Silver, Daniel J.; Steindler, Dennis A.

    2009-01-01

    In addition to radial glial cells of neurohistogenesis, immature astrocytes with stem-cell-like properties cordon off emerging functional patterns in the developing brain. Astrocytes also can be stem cells during adult neurogenesis, and a proposed potency of injury-associated reactive astrocytes has recently been substantiated. Astrocytic cells might additionally be involved in cancer stem cell-associated gliomagenesis. Thus, there are distinguishing roles for stem-cell-like astrocytes during...

  5. The National Cancer Institute's PREVENT Cancer Preclinical Drug Development Program: overview, current projects, animal models, agent development strategies, and molecular targets.

    Science.gov (United States)

    Shoemaker, Robert H; Suen, Chen S; Holmes, Cathy A; Fay, Judith R; Steele, Vernon E

    2016-02-01

    The PREVENT Cancer Preclinical Drug Development Program (PREVENT) is a National Cancer Institute, Division of Cancer Prevention (NCI, DCP)-supported program whose primary goal is to bring new cancer preventive interventions (small molecules and vaccines) and biomarkers through preclinical development towards clinical trials by creating partnerships between the public sector (eg, academia, industry) and DCP. PREVENT has a formalized structure for moving interventions forward in the prevention pipeline using a stage-gate process with go/no go decision points along the critical path for development. This review describes the structure of the program, its focus areas, and provides examples of projects currently in the pipeline. PMID:26970137

  6. Using lessons from breast, cervical, and colorectal cancer screening to inform the development of lung cancer screening programs.

    Science.gov (United States)

    Armstrong, Katrina; Kim, Jane J; Halm, Ethan A; Ballard, Rachel M; Schnall, Mitchell D

    2016-05-01

    Multiple advisory groups now recommend that high-risk smokers be screened for lung cancer by low-dose computed tomography. Given that the development of lung cancer screening programs will face many of the same issues that have challenged other cancer screening programs, the National Cancer Institute-funded Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) consortium was used to identify lessons learned from the implementation of breast, cervical, and colorectal cancer screening that should inform the introduction of lung cancer screening. These lessons include the importance of developing systems for identifying and recruiting eligible individuals in primary care, ensuring that screening centers are qualified and performance is monitored, creating clear communication standards for reporting screening results to referring physicians and patients, ensuring follow-up is available for individuals with abnormal test results, avoiding overscreening, remembering primary prevention, and leveraging advances in cancer genetics and immunology. Overall, this experience emphasizes that effective cancer screening is a multistep activity that requires robust strategies to initiate, report, follow up, and track each step as well as a dynamic and ongoing oversight process to revise current screening practices as new evidence regarding screening is created, new screening technologies are developed, new biological markers are identified, and new approaches to health care delivery are disseminated. Cancer 2016;122:1338-1342. © 2016 American Cancer Society. PMID:26929386

  7. Recommendations for cervical cancer screening programs in developing countries: the need for equity and technological development

    Directory of Open Access Journals (Sweden)

    Lazcano-Ponce Eduardo

    2003-01-01

    Full Text Available The cervical cancer screening programs (CCSP have not been very efficient in the developing countries. This explains the need to foster changes on policies, standards, quality control mechanisms, evaluation and integration of new screening alternatives considered as low and high cost, as well as to regulate colposcopy practices and the foundation of HPV laboratories. Cervical cancer (CC is a disease most frequently found in poverty-stricken communities and reflecting a problem of equity at both levels gender and regional, and this, is not only due to social and economic development inequalities, but to the infrastructure and human resources necessary for primary care. For this reason, the CCSP program must be restructured, a to primarily address unprivileged rural and urban areas; b to foster actions aimed at ensuring extensive coverage as well as a similar quality of that coverage in every region; c to use screening strategies in keeping with the availability of health care services. In countries with a great regional heterogeneity, a variety of screening procedures must be regulated and standardized, including a combination of assisted visual inspection, cervical cytology and HPV detection; d regional community intervention must be set up to assess the effectiveness of using HPV detection as an strategy in addition to cervical cytology (pap smear; e the practice of colposcopy must be regulated to prevent the use of it in healthy women at a population level, thus preventing unnecessary diagnosis and treatment which not only are expensive but also causes unnecessary anxiety to women at risk; f the operation of those clinical laboratories using HPV as a detection strategy must likewise be accredited and regulated and g the CCSP program for assuring health care quality should meet the expectations of its beneficiaries, and increase the knowledge in cervical cancer related matters. Finally, though a variety of clinical tests on prophylactic and

  8. PREVENT Cancer Preclinical Drug Development Program (PREVENT) | Division of Cancer Prevention

    Science.gov (United States)

    The PREVENT program provides a structure for the introduction of new agents, drugs and vaccines to inhibit, retard or reverse the cancer process. The program was designed to optimize translational opportunities from discovery to the clinic, and provide a mechanism to identify and study efficacy and pharmacodynamics biomarkers that will help in phase II trials to evaluate drug effects.  | Research pipeline for new prevention interventions and biomarkers headed toward clinical trials.

  9. Development of Foot Massage Program on Nausea and Vomiting for Cancer Patients: A Literature Review

    Directory of Open Access Journals (Sweden)

    Ni Ketut Guru Prapti

    2012-08-01

    Full Text Available Objective: This study aims to develop a foot massage program to support care activity in reducing nausea and vomiting for cancer patients undergoing chemotherapy. Two phases, a literature review and the development of a foot massage program were conducted. The literature review was to analyze state of the art massage techniques by reviewing problems, related theories and supporting evidence. Method: Eight published studies in the English language were reviewed. A massage can be performed for different durations, from 10 minutes up to 60 minutes for three to six weeks and can be applied on various body areas. We found that the soft stroke/effleurage seems to be the best method and is most suitable for patients with cancer. It is also evident that foot massaging can be applied as a modality to reduce nausea and vomiting for cancer patients undergoing chemotherapy. Result: We developed a foot massage program specifically for patients with cancer. The foot massage program comprised of three sessions, including 1 education session, 2 preparation session, and 3 foot massage session. In the education session, patients obtain brief information about the definition of a foot massage, the benefits and contraindication of foot massaging. During the preparation phase, foot soaking and warming up are performed. Subsequently, the foot massage is applied and should last for 30 minutes. Further research is recommended to test the effectiveness of the proposed foot massage program for nausea and vomiting in cancer patients across countries including Indonesia. Key Words: Foot massage program, chemotherapy, nausea and vomiting

  10. Development of Foot Massage Program on Nausea and Vomiting for Cancer Patients: A Literature Review

    OpenAIRE

    Ni Ketut Guru Prapti; Wongchan Petpichetchian; Wimonrat Chongcharoen

    2012-01-01

    Objective: This study aims to develop a foot massage program to support care activity in reducing nausea and vomiting for cancer patients undergoing chemotherapy. Two phases, a literature review and the development of a foot massage program were conducted. The literature review was to analyze state of the art massage techniques by reviewing problems, related theories and supporting evidence. Method: Eight published studies in the English language were reviewed. A massage can be performed for ...

  11. Development and evaluation of a support program for prostate cancer survivors in Alaska

    Directory of Open Access Journals (Sweden)

    Stacy Kelley

    2015-11-01

    Full Text Available Background: Prostate cancer survivors in Alaska and elsewhere have unmet support needs. The Men's Prostate Cancer Survivorship Retreat, or “men's retreat,” was developed targeting Alaska Native and non-Native men who were survivors of prostate cancer. The program brought together survivors in a supportive environment to discuss and share their experiences. Objective: Despite the proven effectiveness of support groups for improving quality of life for cancer patients, men typically do not participate in formal support groups. This descriptive study was conducted to explore the needs of Alaska Native and non-Native prostate cancer survivors and assess satisfaction and acceptability of a men's cancer survivorship retreat in Alaska. Methods: Prostate cancer survivors (N=80 who attended men's retreats during 2009–2013 were asked to complete a retreat application and post-retreat evaluation. Comments regarding social support, helpful and valuable aspects of the retreat including overall satisfaction were reported. Results: A men's retreat with activities that engage men can be successful for prostate cancer survivors. Many men returned for successive retreats. After the retreat, 97% of the participants said they would continue with support activities. Conclusion: The men's retreat provides a valued opportunity for men to interact with other survivors and access information from health professionals. The results from this study highlight a successful model for social support and resources specific to male prostate cancer survivors.

  12. Development and Pilot Evaluation of Native CREST – a Cancer Research Experience and Student Training Program for Navajo Undergraduate Students

    OpenAIRE

    Hughes, Christine A; Bauer, Mark C.; Horazdovsky, Bruce F.; Garrison, Edward R.; Patten, Christi A.; Petersen, Wesley O.; Bowman, Clarissa N.; Vierkant, Robert A.

    2013-01-01

    The Mayo Clinic Cancer Center and Diné College received funding for a 4-year collaborative P20 planning grant from the National Cancer Institute in 2006. The goal of the partnership was to increase Navajo undergraduates’ interest in and commitment to biomedical coursework and careers, especially in cancer research. This paper describes the development, pilot testing and evaluation of Native CREST (Cancer Research Experience & Student Training), a 10-week cancer research training program provi...

  13. Estimating Development Cost for a Tailored Interactive Computer Program to Enhance Colorectal Cancer Screening Compliance

    OpenAIRE

    Lairson, David R.; Chang, Yu-Chia; Bettencourt, Judith L.; Vernon, Sally W.; Greisinger, Anthony

    2006-01-01

    The authors used an actual-work estimate method to estimate the cost of developing a tailored interactive computer education program to improve compliance with colorectal cancer screening guidelines in a large multi-specialty group medical practice. Resource use was prospectively collected from time logs, administrative records, and a design and computing subcontract. Sensitivity analysis was performed to examine the uncertainty of the overhead cost rate and other parameters. The cost of deve...

  14. Exercise in clinical cancer care: a call to action and program development description

    OpenAIRE

    Santa Mina, D.; Alibhai, S.M.H.; Matthew, A.G.; Guglietti, C.L.; Steele, J.; Trachtenberg, J; Ritvo, P. G.

    2012-01-01

    A large and convincing body of evidence demonstrates the benefits of exercise for cancer survivors during and after treatment. Based on that literature, more cancer survivors should be offered exercise support and programming. Unfortunately, exercise programs remain an exception rather than the norm in cancer care. Not surprisingly, common barriers to the implementation of exercise programs in oncology include limited resources, expertise, and awareness of benefits on the part of patients and...

  15. In memoriam: an appreciation for the NCI R25T cancer education and career development program.

    Science.gov (United States)

    Chang, Shine

    2014-06-01

    On September 7, 2013, the NCI R25T award mechanism ended its final "receipt/review/award cycle" after more than two decades shaping the cancer prevention and control workforce. Created in 1991 to respond to a national shortage of cancer prevention and control researchers, the R25T supported innovative institutional programs with specialized curricula preparing individuals for careers as independent scientists for the field. Required elements ensured developing transdisciplinary sensibilities and skills highly suited to team science, including conducting collaborative research with mentors of complementary expertise. R25Ts provided trainee stipends, research, education, and travel funds at levels far higher than T32 National Service Research Awards to attract individuals from diverse disciplines. Graduates are faculty at all academic ranks, and hold leadership positions such as associate directors of cancer prevention and control. Beyond its trainees, R25Ts also recruited into the field other students exposed through courses in specialized prevention curricula, as well as course instructors and trainee mentors, who did not initially consider their work to be relevant to cancer prevention. Although advances are being achieved, prevention efforts are not yet fully realized, and currently unknown is the impact on the workforce of terminating the R25T, including whether it is another barrier to preventing cancer. PMID:24895444

  16. Cancer diagnosis program

    International Nuclear Information System (INIS)

    The Peralta Cancer Research Institute has organized the Breast Diagnostic Center (BDC) to make available to women information about the breast, and to conduct clinical research to improve methods for early diagnosis and treatment of breast disease. Women entering the center are educated about the anatomy and physiology of the breast, signs of both benign and malignant disease, and factors that influence the risk of developing cancer. The BDC program proposes to demonstrate that the combined use of various diagnostic modalities, when each modality is used at maximum potential, can detect cancers at an earlier stage. Emphasis is placed on the physical examination, using nipple aspiration cytology, contrast ductography, fine-needle aspirations, and mammography. With the financial participation of the Clorox Company, it is shown that the concept of the BDC is economically sound and fills a need in the community

  17. The Development of a Mindfulness-Based Music Therapy (MBMT) Program for Women Receiving Adjuvant Chemotherapy for Breast Cancer.

    Science.gov (United States)

    Lesiuk, Teresa

    2016-01-01

    Problems with attention and symptom distress are common clinical features reported by women who receive adjuvant chemotherapy for breast cancer. Mindfulness practice significantly improves attention and mindfulness programs significantly reduce symptom distress in patients with cancer, and, more specifically, in women with breast cancer. Recently, a pilot investigation of a music therapy program, built on core attitudes of mindfulness practice, reported significant benefits of enhanced attention and decreased negative mood and fatigue in women with breast cancer. This paper delineates the design and development of the mindfulness-based music therapy (MBMT) program implemented in that pilot study and includes clients' narrative journal responses. Conclusions and recommendations, including recommendation for further exploration of the function of music in mindfulness practice are provided. PMID:27517966

  18. Development and evaluation of a cancer-related fatigue patient education program: protocol of a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Görres Stefan

    2008-07-01

    Full Text Available Abstract Background Cancer-related fatigue (CRF and its impact on patients' quality of life has been an increasing subject of research. However, in Germany there is a lack of evidence-based interventions consistent with the multidimensional character of fatigue. The objective of this study is to develop and evaluate a self-management program for disease-free cancer patients to cope with CRF. Methods Based on evidence extracted from a literature review, a curriculum for the self-management program was elaborated. The curriculum was reviewed and validated by an interdisciplinary expert group and the training-modules will be pretested with a small number of participants and discussed in terms of feasibility and acceptance. To determine the efficacy of the program a randomised controlled trial will be carried out: 300 patients will be recruited from oncological practices in Bremen, Germany, and will be allocated to intervention or control group. The intervention group participates in the program, whereas the control group receives standard care and the opportunity to take part in the program after the end of the follow-up (waiting control group. Primary outcome measure is the level of fatigue, secondary outcome measures are quality of life, depression, anxiety, self-efficacy and physical activity. Data will be collected before randomisation, after intervention, and after a follow-up of 6 months. Discussion Because there are no comparable self-management programs for cancer survivors with fatigue, the development of the curriculum has been complex; therefore, the critical appraisal by the experts was an important step to validate the program and their contributions have been integrated into the curriculum. The experts appreciated the program as filling a gap in outpatient cancer care. If the results of the evaluation prove to be satisfactory, the outpatient care of cancer patients can be broadened and supplemented. Trial Registration Clinical

  19. A Wellness Program for Cancer Survivors and Caregivers: Developing an Integrative Pilot Program with Exercise, Nutrition, and Complementary Medicine.

    Science.gov (United States)

    Stoutenberg, Mark; Sogor, Alyssa; Arheart, Kris; Cutrono, Stacy E; Kornfeld, Julie

    2016-03-01

    The Integrative Wellness Program (IWP) at the University of Miami Sylvester Comprehensive Cancer Center (SCCC) sought to provide integrative wellness education to cancer patients, survivors, and caregivers by offering instruction in exercise, nutrition, and complementary and alternative medicine. The objective of this study was to assess the impact of the IWP on the overall wellness of the individuals participating in the program. Three different 10-week versions of the IWP were conducted over a 1-year period. Each session focused on a different wellness topic presented through interactive lectures and applied activities. A series of self-report questionnaires were administered at baseline and again at the completion of the program to assess improvements in physical activity levels, dietary habits, sleep hygiene, and quality of life. Participants were generally older, Caucasian, female, had higher levels of education, and still currently receiving treatment. Significant changes were observed in two measures: Starting the Conversation (-2.0 ± 2.40, p = .037) and the Sticking To It subscale of the Self-Efficacy and Eating Habits Survey (1.7 ± 1.22, p = .0013). A trend for improvement in the Reducing Fat subscale of the Self-Efficacy Eating Habits (0.44 ± 0.60, p = .056) was also observed. Participant satisfaction surveys indicated high levels of satisfaction and applicability of the material presented. The significant improvements detected related to dietary habits, combined with the responses from the participant satisfaction surveys, suggest that the IWP was well received and can positively impact the overall wellness of cancer patients, survivors, and their caregivers. PMID:25663357

  20. Academic-Community Partnership to Develop a Patient-Centered Breast Cancer Risk Reduction Program for Latina Primary Care Patients

    OpenAIRE

    Castañeda, Sheila F.; Rebeca E. Giacinto; Medeiros, Elizabeth A.; Brongiel, Ilana; Cardona, Olga; Perez, Patricia; Talavera, Gregory A.

    2015-01-01

    This collaborative study sought to address Latina breast cancer (BC) disparities by increasing health literacy (HL) in a community health center situated on the US-Mexico border region of San Diego County. An academic-community partnership conducted formative research to develop a culturally tailored promotora-based intervention with 109 individuals. The Spanish language program, entitled Nuestra Cocina: Mesa Buena, Vida Sana (Our Kitchen: Good Table, Healthy Life), included six sessions targ...

  1. Programs | Office of Cancer Genomics

    Science.gov (United States)

    OCG facilitates cancer genomics research through a series of highly-focused programs. These programs generate and disseminate genomic data for use by the cancer research community. OCG programs also promote advances in technology-based infrastructure and create valuable experimental reagents and tools. OCG programs encourage collaboration by interconnecting with other genomics and cancer projects in order to accelerate translation of findings into the clinic. Below are OCG’s current, completed, and initiated programs:

  2. Academic-Community Partnership to Develop a Patient-Centered Breast Cancer Risk Reduction Program for Latina Primary Care Patients.

    Science.gov (United States)

    Castañeda, Sheila F; Giacinto, Rebeca E; Medeiros, Elizabeth A; Brongiel, Ilana; Cardona, Olga; Perez, Patricia; Talavera, Gregory A

    2016-06-01

    This collaborative study sought to address Latina breast cancer (BC) disparities by increasing health literacy (HL) in a community health center situated on the US-Mexico border region of San Diego County. An academic-community partnership conducted formative research to develop a culturally tailored promotora-based intervention with 109 individuals. The Spanish language program, entitled Nuestra Cocina: Mesa Buena, Vida Sana (Our Kitchen: Good Table, Healthy Life), included six sessions targeting HL, women's health, BC risk reduction, and patient-provider communication; sessions include cooking demonstrations of recipes with cancer-risk-reducing ingredients. A pilot study with 47 community health center Latina patients was conducted to examine the program's acceptability, feasibility, and ability to impact knowledge and skills. Pre- and post-analyses demonstrated that participants improved their self-reported cancer screening, BC knowledge, daily fruit and vegetable intake, and ability to read a nutrition label (p < 0.05). Results of the pilot study demonstrate the importance of utilizing patient-centered culturally appropriate noninvasive means to educate and empower Latina patients. PMID:27271058

  3. Internal Audit of a Comprehensive IMRT Program for Prostate Cancer: A Model for Centers in Developing Countries?

    International Nuclear Information System (INIS)

    Purpose: With improving regional prosperity, significant capital investments have been made to rapidly expand radiotherapy capacity across Southeast Asia. Yet little has been reported on the implementation of adequate quality assurance (QA) in patient management. The objective of this study is to perform an in-depth QA assessment of our definitive intensity-modulated radiotherapy (IMRT) program for prostate cancer since its inception. Methods and Materials: The department's prostate IMRT program was modeled after that of University of California San Francisco. A departmental protocol consisting of radiotherapy volume/dose and hormone sequencing/duration and a set of 18 dose objectives to the target and critical organs were developed, and all plans were presented at the weekly departmental QA rounds. All patients treated with definitive IMRT for nonmetastatic prostate cancer were retrospectively reviewed. Protocol adherence, dosimetry data, toxicities, and outcomes were evaluated. Results: Since 2005, 76 patients received IMRT: 54 with whole-pelvis and 22 with prostate-only treatment. Of the 1,140 recorded dosimetric end points, 39 (3.3%) did not meet the protocol criteria. At QA rounds, no plans required a revision. Only one major protocol violation was observed. Two and two cases of Grade 3-4 acute and late toxicities, respectively, were observed. Five (8.8%) patients developed proctitis, but only one required argon laser therapy. Conclusions: Our comprehensive, practice-adapted QA measures appeared to ensure that we were able to consistently generate conforming IMRT plans with acceptable toxicities. These measures can be easily integrated into other clinics contemplating on developing such a program.

  4. [Genome-cohort studies for the development of personalized cancer prevention programs in Japan].

    Science.gov (United States)

    Tanaka, Hideo

    2015-05-01

    One of the most important roles of molecular epidemiology is to investigate gene-environment interactions in order to provide data for personalized risk modification. A case-control study conducted in Aichi showed that an aldehyde dehydrogenase- 2(ALDH2)polymorphism together with cigarette smoking significantly affects the risk of lung cancer. The main purpose of this large-scale genome-cohort study of healthy individuals is to confirm that these factors are associated with the development of diseases and to set optimal thresholds for the environmental factors. The Japan Multi-Institutional Collaborative Cohort(J-MICC)Study was launched in 2005. It has recruited 100,600 healthy participants up to the end of 2014, and plans to follow them until 2025. Although Japanese genome-cohort studies, including the J-MICC Study, the Japan Public Health Center-based Prospective(JPHC)Study, and the Tohoku Medical Megabank Organization Study, consist of different research teams with different financial resources, collaboration to standardize the data collection format for successful pooled analysis is being discussed. PMID:25981648

  5. Splicing Programs and Cancer

    OpenAIRE

    Sophie Germann; Lise Gratadou; Martin Dutertre; Didier Auboeuf

    2012-01-01

    Numerous studies report splicing alterations in a multitude of cancers by using gene-by-gene analysis. However, understanding of the role of alternative splicing in cancer is now reaching a new level, thanks to the use of novel technologies allowing the analysis of splicing at a large-scale level. Genome-wide analyses of alternative splicing...

  6. Issues in Designing/Developing Clinical Program Content for a Cancer Center Web Site

    OpenAIRE

    Lundy, Alalia; Salmons, Theodora Xenia

    2001-01-01

    Content Management for healthcare websites entails the creation, modification, and removal of clinical information on a website by web development technical teams. This poster addresses issues in successful clinical website Content Management. The main obstacle to successful Content Management is the challenge of interaction between healthcare (clinical content) provider and technocrat (web developer). When developing the presentation of clinical information, the foremost issue (after informa...

  7. Cancer Therapy Evaluation Program | Office of Cancer Genomics

    Science.gov (United States)

    The Cancer Therapy Evaluation Program (CTEP) seeks to improve the lives of cancer patients by finding better treatments, control mechanisms, and cures for cancer. CTEP funds a national program of cancer research, sponsoring clinical trials to evaluate new anti-cancer agents.

  8. Clinical Assay Development Support - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The NCI’s Division of Cancer Treatment and Diagnosis and the Cancer Diagnosis Program announce a request for applications for the Clinical Assay Development Program (CADP) for investigators seeking clinical assay development and validation resources.

  9. Developing Parallel Programs

    OpenAIRE

    Ranjan Sen

    2012-01-01

    Parallel programming is an extension of sequential programming; today, it is becoming the mainstream paradigm in day-to-day information processing. Its aim is to build the fastest programs on parallel computers. The methodologies for developing a parallelprogram can be put into integrated frameworks. Development focuses on algorithm, languages, and how the program is deployed on the parallel computer.

  10. Development of a survivorship program.

    Science.gov (United States)

    Downs-Holmes, Catherine; Dracon, Andrea; Svarovsky, Therese; Sustin, Marla

    2014-01-01

    The number of cancer survivors has steadily climbed to more than 10 million since the 1980s secondary to advances in detection and treatment modalities. This reality, combined with an aging population, has drawn the attention of the medical community to meet the needs of this population. Therefore, cancer care providers are being called to develop survivorship programs for patients with curable disease. Some of the prominent organizations supporting this movement for focused survivorship care include the Institute of Medicine, the National Comprehensive Cancer Network, the American Society of Clinical Oncology, LiveStrong™, and the Oncology Nursing Society. This article provides the necessary steps for the development and implementation of an institution-specific survivorship program to fulfill the new standards for survivorship care. PMID:25252995

  11. The eCALM Trial-eTherapy for cancer appLying mindfulness: online mindfulness-based cancer recovery program for underserved individuals living with cancer in Alberta: protocol development for a randomized wait-list controlled clinical trial

    OpenAIRE

    Zernicke Kristin A; Campbell Tavis S; Speca Michael; McCabe-Ruff Kelley; Flowers Steven; Dirkse Dale A; Carlson Linda E

    2013-01-01

    Abstract Background Elevated stress can exacerbate cancer symptom severity, and after completion of primary cancer treatments, many individuals continue to have significant distress. Mindfulness-Based Cancer Recovery (MBCR) is an 8-week group psychosocial intervention consisting of training in mindfulness meditation and yoga designed to mitigate stress, pain, and chronic illness. Efficacy research shows face-to-face (F2F) MBCR programs have positive benefits for cancer patients; however barri...

  12. Developments in Colorectal Cancer Screening

    Science.gov (United States)

    ... on. Feature: Colorectal Cancer Developments in Colorectal Cancer Screening Summer 2016 Table of Contents Dr. Asad Umar, ... know to help determine the best colon cancer screening test for them? Colonoscopy is considered the gold ...

  13. Pancreatic Cancer Early Detection Program

    Science.gov (United States)

    2014-07-30

    Pancreatic Cancer; Pancreas Cancer; Pancreatic Adenocarcinoma; Familial Pancreatic Cancer; BRCA 1/2; HNPCC; Lynch Syndrome; Hereditary Pancreatitis; FAMMM; Familial Atypical Multiple Mole Melanoma; Peutz Jeghers Syndrome

  14. Breast Cancer and the Environment Research Program

    Science.gov (United States)

    The Breast Cancer and the Environment Research Program supports a multidisciplinary network of scientists, clinicians, and community partners to examine the effects of environmental exposures that may predispose a woman to breast cancer throughout her life.

  15. Colon Cancer Risk Assessment - Gauss Program

    Science.gov (United States)

    An executable file (in GAUSS) that projects absolute colon cancer risk (with confidence intervals) according to NCI’s Colorectal Cancer Risk Assessment Tool (CCRAT) algorithm. GAUSS is not needed to run the program.

  16. Development of cancer immunotherapy

    International Nuclear Information System (INIS)

    To increase the curative rate of cancer patients, we developed ideal biological response modifier from medicinal plants: Ginsan, KC68IId-8, KC-8Ala, KG-30. Ginsan activated natural killer cell activity of spleen cells more than 5.4 times than lentinan, 1.4 times than picibanil. Radioprotective activity of Ginsan is stronger than WR2721, glucan, and selenium. The immunogenicity of MOPC tumor cells was augmented by treatment with IL-10 antisense oligonucleotide and by transfection with VEGF sense-, antisense gene. The immunogenicity of MOPC tumor cells was augmented by treatment with IL-10 antisense oligonucleotide and by transfection with VEGF sense-, antisense gene. The immunogenicity of A20 tumor cells was also augmented by transfection with B7.1 gene. The immunosuppression of gamma-irradiation was due to the reduction of Th1 sytokine gene expression through STAT pathway. These research will devote to develop new cancer immunotherapy and to reduce side effect of cancer radiotherapy and chemotherapy

  17. Development of cancer immunotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Yun, Yeon Sook; Chung, H. Y.; Yi, S. Y.; Kim, K. W.; Kim, B. K.; Chung, I. S.; Park, J. Y

    1999-04-01

    To increase the curative rate of cancer patients, we developed ideal biological response modifier from medicinal plants: Ginsan, KC68IId-8, KC-8Ala, KG-30. Ginsan activated natural killer cell activity of spleen cells more than 5.4 times than lentinan, 1.4 times than picibanil. Radioprotective activity of Ginsan is stronger than WR2721, glucan, and selenium. The immunogenicity of MOPC tumor cells was augmented by treatment with IL-10 antisense oligonucleotide and by transfection with VEGF sense-, antisense gene. The immunogenicity of MOPC tumor cells was augmented by treatment with IL-10 antisense oligonucleotide and by transfection with VEGF sense-, antisense gene. The immunogenicity of A20 tumor cells was also augmented by transfection with B7.1 gene. The immunosuppression of gamma-irradiation was due to the reduction of Th1 sytokine gene expression through STAT pathway. These research will devote to develop new cancer immunotherapy and to reduce side effect of cancer radiotherapy and chemotherapy.

  18. Cancer Control Research Training for Native Researchers: A Model for Development of Additional Native Researcher Training Programs

    Science.gov (United States)

    Becker, Thomas M.; Dunn, Esther; Tom-Orme, Lillian; Joe, Jennie

    2005-01-01

    Several social and biological scientists who have Native status are engaged in productive research careers, but the encouragement that has been offered to Native students to formulate career goals devoted to cancer etiology or cancer control in Native peoples has had limited success. Hence, the Native Researchers' Cancer Control Training Program…

  19. Automatic Program Development

    DEFF Research Database (Denmark)

    Automatic Program Development is a tribute to Robert Paige (1947-1999), our accomplished and respected colleague, and moreover our good friend, whose untimely passing was a loss to our academic and research community. We have collected the revised, updated versions of the papers published in his...... honor in the Higher-Order and Symbolic Computation Journal in the years 2003 and 2005. Among them there are two papers by Bob: (i) a retrospective view of his research lines, and (ii) a proposal for future studies in the area of the automatic program derivation. The book also includes some papers by...... members of the IFIP Working Group 2.1 of which Bob was an active member. All papers are related to some of the research interests of Bob and, in particular, to the transformational development of programs and their algorithmic derivation from formal specifications. Automatic Program Development offers a...

  20. Cancer Prevention Fellowship Program (CPFP) | Division of Cancer Prevention

    Science.gov (United States)

    The Cancer Prevention Fellowship provides a strong foundation for scientists and clinicians to train in the field of cancer prevention and control. This structured, multidisciplinary program offers early career scientists from different health disciplines a variety of postdoctoral training opportunities . | Training to form a strong foundation in cancer prevention and control for scientists and clinicians.

  1. The eCALM Trial-eTherapy for cancer appLying mindfulness: online mindfulness-based cancer recovery program for underserved individuals living with cancer in Alberta: protocol development for a randomized wait-list controlled clinical trial

    Directory of Open Access Journals (Sweden)

    Zernicke Kristin A

    2013-02-01

    Full Text Available Abstract Background Elevated stress can exacerbate cancer symptom severity, and after completion of primary cancer treatments, many individuals continue to have significant distress. Mindfulness-Based Cancer Recovery (MBCR is an 8-week group psychosocial intervention consisting of training in mindfulness meditation and yoga designed to mitigate stress, pain, and chronic illness. Efficacy research shows face-to-face (F2F MBCR programs have positive benefits for cancer patients; however barriers exist that impede participation in F2F groups. While online MBCR groups are available to the public, none have been evaluated. Primary objective: determine whether underserved patients are willing to participate in and complete an online MBCR program. Secondary objectives: determine whether online MBCR will mirror previous efficacy findings from F2F MBCR groups on patient-reported outcomes. Method/design The study includes cancer patients in Alberta, exhibiting moderate distress, who do not have access to F2F MBCR. Participants will be randomized to either online MBCR, or waiting for the next available group. An anticipated sample size of 64 participants will complete measures online pre and post treatment or waiting period. Feasibility will be tracked through monitoring numbers eligible and participating through each stage of the protocol. Discussion 47 have completed/completing the intervention. Data suggest it is possible to conduct a randomized waitlist controlled trial of online MBCR to reach underserved cancer survivors. Trial registration Clinical Trials.gov Identifier: NCT01476891

  2. The Early Prostate Cancer program: bicalutamide in nonmetastatic prostate cancer

    DEFF Research Database (Denmark)

    Iversen, Peter; Roder, Martin Andreas; Røder, Martin Andreas

    2008-01-01

    The Early Prostate Cancer program is investigating the addition of bicalutamide 150 mg to standard care for localized or locally advanced, nonmetastatic prostate cancer. The third program analysis, at 7.4 years' median follow-up, has shown that bicalutamide 150 mg does not benefit patients with...

  3. Integrative Medicine Program- MD Anderson Cancer Center

    OpenAIRE

    Lee, Richard T.

    2012-01-01

    The Integrative Medicine Program at MD Anderson Cancer Center was first established in 1998.  Our mission is to empower patients with cancer and their families to become active partners in their own physical, psycho-spiritual, and social health through personalized education and evidenced-based clinical care to optimize health, quality of life, and clinical outcomes across the cancer continuum.  The program consists of three main components: clinical care, research, and education.  The Integr...

  4. Developing hazardous waste programs

    Science.gov (United States)

    Showstack, Randy

    Developing a fully operational hazardous waste regulatory system requires at least 10 to 15 years—even in countries with strong legal and bureaucratic institutions, according to a report on "The Evolution of Hazardous Waste Programs," which was funded by Resources for the Future (RFF) and the World Bank's South Asia Environment Group, and issued on June 4.The report, which compares the experiences of how four developed and four developing countries have created hazardous waste programs, indicates that hazardous waste issues usually do not become a pressing environmental issue until after countries have dealt with more direct threats to public health, such as contaminated drinking water and air pollution. The countries examined include Indonesia, Thailand, Germany, and the United States.

  5. Robotics Technology Development Program

    International Nuclear Information System (INIS)

    The Robotics Technology Development Program (RTDP) is a ''needs-driven'' effort. A lengthy series of presentations and discussions at DOE sites considered critical to DOE's Environmental Restoration and Waste Management (EM) Programs resulted in a clear understanding of needed robotics applications toward resolving definitive problems at the sites. A detailed analysis of the Tank Waste Retrieval (TWR), Contaminant Analysis Automation (CAA), Mixed Waste Operations (MWO), and Decontamination ampersand Dismantlement (D ampersand D). The RTDP Group realized that much of the technology development was common (Cross Cutting-CC) to each of these robotics application areas, for example, computer control and sensor interface protocols. Further, the OTD approach to the Research, Development, Demonstration, Testing, and Evaluation (RDDT ampersand E) process urged an additional organizational break-out between short-term (1--3 years) and long-term (3--5 years) efforts (Advanced Technology-AT). The RDTP is thus organized around these application areas -- TWR, CAA, MWO, D ampersand D and CC ampersand AT -- with the first four developing short-term applied robotics. An RTDP Five-Year Plan was developed for organizing the Program to meet the needs in these application areas

  6. Canadian fuel development program

    International Nuclear Information System (INIS)

    CANDU power reactor fuel has demonstrated an enviable operational record. More than 99.9% of the bundles irradiated have provided defect-free service. Defect excursions are responsible for the majority of reported defects. In some cases research and development effort is necessary to resolve these problems. In addition, development initiatives are also directed at improvements of the current design or reduction of fueling cost. The majority of the funding for this effort has been provided by COG (CANDU Owners' Group) over the past 10 to 15 years. This paper contains an overview of some key fuel technology programs within COG. The CANDU reactor is unique among the world's power reactors in its flexibility and its ability to use a number of different fuel cycles. An active program of analysis and development, to demonstrate the viability of different fuel cycles in CANDU, has been funded by AECL in parallel with the work on the natural uranium cycle. Market forces and advances in technology have obliged us to reassess and refocus some parts of our effort in this area, and significant success has been achieved in integrating all the Canadian efforts in this area. This paper contains a brief summary of some key components of the advanced fuel cycle program. (Author) 4 figs., tab., 18 refs

  7. Biofuels feedstock development program

    International Nuclear Information System (INIS)

    The Department of Energy's (DOE's) Biofuels Feedstock Development Program (BFDP) leads the nation in the research, development, and demonstration of environmentally acceptable and commercially viable dedicated feedstock supply systems (DFSS). The purpose of this report is to highlight the status and accomplishments of the research that is currently being funded by the BFDP. Highlights summarized here and additional accomplishments are described in more detail in the sections associated with each major program task. A few key accomplishments include (1) development of a methodology for doing a cost-supply analysis for energy crops and the application of that methodology to looking at possible land use changes around a specific energy facility in East Tennessee; (2) preliminary documentation of the relationship between woody crop plantation locations and bird diversity at sites in the Midwest, Canada, and the pacific Northwest supplied indications that woody crop plantations could be beneficial to biodiversity; (3) the initiation of integrated switchgrass variety trials, breeding research, and biotechnology research for the south/southeast region; (4) development of a data base management system for documenting the results of herbaceous energy crop field trials; (5) publication of three issues of Energy Crops Forum and development of a readership of over 2,300 individuals or organizations as determined by positive responses on questionnaires

  8. Cancer epidemiology in developing countries

    International Nuclear Information System (INIS)

    It is estimated that there were over 10 million new cancer cases in 2000, 5.4 million of them occurring in the developing countries (Parkin et al, 2001). The marked geographical variation in cancer occurrence results in differing therapeutic priorities: North America has more new cancer cases than South-Central Asia, but there are more deaths from cancer in South-Central Asia, reflecting a different pattern of cancer rather than differences in prognosis. Prediction of future trends is difficult, but the impact of population increase and ageing will be significant, with an expected 63% increase in the population of the less developed countries in 50 years. Four sites of cancer namely breast, cervix, colorectal and nasopharyngeal carcinoma are reviewed, looking at their present and possible future importance in the context of developing countries and their aetiology

  9. Northeast Regional Cancer Institute's Cancer Surveillance and Risk Factor Program

    Energy Technology Data Exchange (ETDEWEB)

    Lesko, Samuel M.

    2007-07-31

    OBJECTIVES The Northeast Regional Cancer Institute is conducting a program of ongoing epidemiologic research to address cancer disparities in northeast Pennsylvania. Of particular concern are disparities in the incidence of, stage at diagnosis, and mortality from colorectal cancer. In northeast Pennsylvania, age-adjusted incidence and mortality rates for colorectal cancer are higher, and a significantly smaller proportion of new colorectal cancer cases are diagnosed with local stage disease than is observed in comparable national data. Further, estimates of the prevalence of colorectal cancer screening in northeast Pennsylvania are lower than the US average. The Northeast Regional Cancer Institute’s research program supports surveillance of common cancers, investigations of cancer risk factors and screening behaviors, and the development of resources to further cancer research in this community. This project has the following specific objectives: I. To conduct cancer surveillance in northeast Pennsylvania. a. To monitor incidence and mortality for all common cancers, and colorectal cancer, in particular, and b. To document changes in the stage at diagnosis of colorectal cancer in this high-risk, underserved community. II. To conduct a population-based study of cancer risk factors and screening behavior in a six county region of northeast Pennsylvania. a. To monitor and document changes in colorectal cancer screening rates, and b. To document the prevalence of cancer risk factors (especially factors that increase the risk of colorectal cancer) and to identify those risk factors that are unusually common in this community. APPROACH Cancer surveillance was conducted using data from the Northeast Regional Cancer Institute’s population-based Regional Cancer Registry, the Pennsylvania Cancer Registry, and NCI’s SEER program. For common cancers, incidence and mortality were examined by county within the region and compared to data for similar populations in the US

  10. Development of New Treatments for Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    DiPaola, R. S.; Abate-Shen, C.; Hait, W. N.

    2005-02-01

    The Dean and Betty Gallo Prostate Cancer Center (GPCC) was established with the goal of eradicating prostate cancer and improving the lives of men at risk for the disease through research, treatment, education and prevention. GPCC was founded in the memory of Dean Gallo, a beloved New Jersey Congressman who died tragically of prostate cancer diagnosed at an advanced stage. GPCC unites a team of outstanding researchers and clinicians who are committed to high-quality basic research, translation of innovative research to the clinic, exceptional patient care, and improving public education and awareness of prostate cancer. GPCC is a center of excellence of The Cancer Institute of New Jersey, which is the only NCI-designated comprehensive cancer center in the state. GPCC efforts are now integrated well as part of our Prostate Program at CINJ, in which Dr. Robert DiPaola and Dr. Cory Abate-Shen are co-leaders. The Prostate Program unites 19 investigators from 10 academic departments who have broad and complementary expertise in prostate cancer research. The overall goal and unifying theme is to elucidate basic mechanisms of prostate growth and oncogenesis, with the ultimate goal of promoting new and effective strategies for the eradication of prostate cancer. Members' wide range of research interests collectively optimize the chances of providing new insights into normal prostate biology and unraveling the molecular pathophysiology of prostate cancer. Cell culture and powerful animal models developed by program members recapitulate the various stages of prostate cancer progression, including prostatic intraepithelial neoplasia, adenocarcinoma, androgen-independence, invasion and metastases. These models promise to further strengthen an already robust program of investigator-initiated therapeutic clinical trials, including studies adopted by national cooperative groups. Efforts to translate laboratory results into clinical studies of early detection and

  11. Program development fund

    International Nuclear Information System (INIS)

    It is the objective of the Fund to encourage innovative research to maintain the Laboratory's position at the forefront of science. Funds are used to explore new ideas and concepts that may potentially develop into new directions of research for the Laboratory and that are consistent with the major needs, overall goals, and mission of the Laboratory and the DOE. The types of projects eligible for support from PDF include: work in forefront areas of science and technology for the primary purpose of enriching Laboratory research and development capabilities; advanced study of new hypotheses, new experimental concepts, or innovative approaches to energy problems; experiments directed toward ''proof of principle'' or early determination of the utility of a new concept; and conception, design analyses, and development of experimental devices, instruments, or components. This report is a review of these research programs

  12. Atopy and development of cancer

    DEFF Research Database (Denmark)

    Skaaby, Tea; Nystrup Husemoen, Lise Lotte; Roswall, Nina;

    2014-01-01

    BACKGROUND: Atopy is the familial or personal propensity to develop IgE antibodies against environmental allergens. Atopy, theoretically, could both prevent and promote the development of cancer. However, evidence from epidemiologic studies has been inconclusive. OBJECTIVE: We investigated the...

  13. Single Institution Feasibility Trials - Cancer Imaging Program

    Science.gov (United States)

    Within the CIP program, the current R21 mechanism provides potential funding for small, single institution feasibility trials. The current announcement is titled In Vivo Cancer Imaging Exploratory/Developmental Grants.

  14. ABC Technology Development Program

    International Nuclear Information System (INIS)

    The Accelerator-Based Conversion (ABC) facility will be designed to accomplish the following mission: 'Provide a weapon's grade plutonium disposition capability in a safe, economical, and environmentally sound manner on a prudent schedule for [50] tons of weapon's grade plutonium to be disposed on in [20] years.' This mission is supported by four major objectives: provide a reliable plutonium disposition capability within the next [15] years; provide a level of safety and of safety assurance that meets or exceeds that afforded to the public by modern commercial nuclear power plants; meet or exceed all applicable federal, state, and local regulations or standards for environmental compliance; manage the program in a cost effective manner. The ABC Technology Development Program defines the technology development activities that are required to accomplish this mission. The technology development tasks are related to the following topics: blanket system; vessel systems; reactivity control systems; heat transport system components; energy conversion systems; shutdown heat transport systems components; auxiliary systems; technology demonstrations - large scale experiments

  15. WANO. Development, programs, challenges

    International Nuclear Information System (INIS)

    In the wake of the accident at the Soviet RBMK reactor unit 4 in Chernobyl the nuclear industry founded the World Association of Nuclear Operators (WANO). To this day, the purpose of the organization has been to enhance worldwide cooperation of nuclear industry and, in this way, strengthen the safety and availability of nuclear power plants. Following some first steps after 1986, the charter of the organization was signed at the WANO constituent assembly in Moscow on May 15 and 16, 1989. The member companies thus committed themselves to support WANO's mission. WANO was established for these purposes: ''The mission of WANO is to maximize the safety and reliability of nuclear power plants worldwide by working together to assess, benchmark and improve performance through mutual support, exchange of information, and emulation of best practices.'' The WANO programs developed speedily thereafter. The focus was on peer reviews. In 2000, the first interim objective had been reached: Fifty percent of all member nuclear power plants had undergone peer reviews. In addition, plant-related peer reviews were extended throughout all operator organizations, and corporate peer reviews were developed. The other WANO programs as well, i.e. exchanges of experience, technical support, and performance indicators, exerted more and more influence on industry. Peer reviews covered entire operator organizations, and corporate peer reviews were developed. The worldwide paradigm shift in evaluating the use of nuclear power, and the associated construction programs for new nuclear power plants already in their implementation phase, assigned a new quality to the work of WANO. The organization is preparing a long-term strategy in the face of the challenges to be expected. The ultimate objective of these efforts is to support member organizations from the first preparations of a nuclear power plant project to the end of commercial operation. (orig.)

  16. Assessment of a cancer screening program.

    Science.gov (United States)

    Rabeneck, Linda; Lansdorp-Vogelaar, Iris

    2015-12-01

    Several Asian countries are implementing nationwide cancer screening programs. Assessment of the effectiveness of these programs is critical to their success as this is the only way to ensure that the benefits of screening outweigh the harms. In this paper we focus on colorectal cancer (CRC) screening to illustrate the principles of screening program assessment. The International Agency for Research on Cancer (IARC) has defined organized screening, distinguishing it from opportunistic screening. The key advantage of organized screening is that it provides greater protection against the possible harms of screening. Since screening is a process, not simply a test, the effectiveness of a program depends on the quality of each step in the cancer screening process. The evaluation of long-term screening program outcomes (CRC incidence and mortality) will not be observable for many years, given the time it takes to plan, pilot and implement a program. However, early performance indicators of the impact of screening should be monitored to give an early indication whether the program is on track. The European Union (EU) has recommended a minimum dataset to be collected and reported regularly by a screening program. Using information from these data tables, early performance indicators can be generated (e.g., participation rate, proportion of screen-detected cancers that are early-stage). Subsequently, modeling the natural history of the disease can be very helpful to estimate long-term outcomes, making use of these directly measured early performance indicators. Modeling can also be used to estimate the cost-effectiveness of a screening program and the potential impact of changes in policy, as illustrated by its recent use in the Netherlands to change the definition of a positive fecal immunochemical test (FIT) for the CRC screening program. Programs should consider modeling as an important component of screening program evaluation. PMID:26651258

  17. Start-Up of the Colorectal Cancer Screening Demonstration Program

    Directory of Open Access Journals (Sweden)

    Amy DeGroff, MPH

    2008-04-01

    Full Text Available IntroductionIn 2005, the Centers for Disease Control and Prevention funded five sites to implement the Colorectal Cancer Screening Demonstration Program (CRCSDP. An evaluation is being conducted that includes a multiple case study. Case study results for the start-up period, the time between initial funding and screening initiation, provide details about the program models and start-up process and reveal important lessons learned.MethodsThe multiple case study includes all five CRCSDP sites, each representing a unique case. Data were collected from August 2005 through September 2006 from documents, observations, and more than 70 interviews with program staff and stakeholders.ResultsSites differed by geographic service area, screening modality selected, and service delivery structure. Program models were influenced by two factors: preexisting infrastructure and the need to adapt programs to fit local service delivery structures. Several sites modeled program components after their National Breast and Cervical Cancer Early Detection Program. Medical advisory boards convened by all sites provided clinical support for developing program policies and quality assurance plans. Partnerships with comprehensive cancer control programs facilitated access to financial and in-kind resources.ConclusionThe program models developed by the CRCSDP sites offer a range of prototypes. Case study results suggest benefits in employing a multidisciplinary staff team, assembling a medical advisory board, collaborating with local partners, using preexisting resources, designing programs that are easily incorporated into existing service delivery systems, and planning for adequate start-up time.

  18. The bicalutamide Early Prostate Cancer Program. Demography

    DEFF Research Database (Denmark)

    See, W A.; McLeod, D; Iversen, P;

    2001-01-01

    BACKGROUND: The optimal treatment for early prostate cancer has yet to be established. A well-tolerated hormonal therapy such as bicalutamide could be a useful treatment option in this setting, either as adjuvant or immediate therapy. A major collaborative clinical trials program was set up to...... investigate bicalutamide as a treatment option for local prostate cancer (localized or locally advanced disease). METHODS: The bicalutamide Early Prostate Cancer program comprises three randomized, double-blind, placebo-controlled trials of similar design that are being conducted in distinct geographical...... areas (North America; Australia, Europe, Israel, South Africa and Mexico; and Scandinavia). Men with T1b-4N0-1M0 (TNM 1997) prostate cancer have been randomized on a 1:1 basis to receive bicalutamide 150 mg daily or placebo. Recruitment to the program closed in July 1998, and follow-up is ongoing. Study...

  19. Radon Control Activities for Lung Cancer Prevention in National Comprehensive Cancer Control Program Plans, 2005–2011

    OpenAIRE

    Antonio Neri, MD, MPH; Sherri L. Stewart, PhD; William Angell, MS

    2013-01-01

    Introduction Radon is the second leading cause of lung cancer among smokers and the leading cause among nonsmokers. The US Environmental Protection Agency recommends that every home be tested for radon. Comprehensive Cancer Control (CCC) programs develop cancer coalitions that coordinate funding and resources to focus on cancer activities that are recorded in cancer plans. Radon tests, remediation, and radon mitigation techniques are relatively inexpensive, but it is unclear whether coalition...

  20. ICMIC Institutions - Cancer Imaging Program

    Science.gov (United States)

    ICMIC grants facilitate interaction among scientists from a variety of fields to conduct multidisciplinary research on cellular and molecular imaging related to cancer. Pre-ICMIC planning grants have provided time and funds for investigators and institutions to prepare themselves, organizationally and scientifically, to establish ICMICs.

  1. Developing an orientation program.

    Science.gov (United States)

    Edwards, K

    1999-01-01

    When the local area experienced tremendous growth and change, the radiology department at Maury Hospital in Columbia, Tennessee looked seriously at its orientation process in preparation for hiring additional personnel. It was an appropriate time for the department to review its orientation process and to develop a manual to serve as both a tool for supervisors and an ongoing reference for new employees. To gather information for the manual, supervisors were asked to identify information they considered vital for new employees to know concerning the daily operations of the department, its policies and procedures, the organizational structure of the hospital, and hospital and departmental computer systems. That information became the basis of the orientation manual, and provided an introduction to the hospital and radiology department; the structure of the organization; an overview of the radiology department; personnel information; operating procedures and computer systems; and various policies and procedures. With the manual complete, the radiology department concentrated on an orientation process that would meet the needs of supervisors who said they had trouble remembering the many details necessary to teach new employees. A pre-orientation checklist was developed, which contained the many details supervisors must handle between the time an employee is hired and arrives for work. The next step was the creation of a checklist for use by the supervisor during a new employee's first week on the job. A final step in the hospital's orientation program is to have each new employee evaluate the entire orientation process. That information is then used to update and revise the manual. PMID:10346648

  2. Breast cancer prevention and control programs in Malaysia.

    Science.gov (United States)

    Dahlui, Maznah; Ramli, Sofea; Bulgiba, Awang M

    2011-01-01

    Breast cancer is the most common cancer in Malaysian females. The National Cancer Registry in 2003 and 2006 reported that the age standardized incidence of breast cancer was 46.2 and 39.3 per 100,000 populations, respectively. With the cumulative risk at 5.0; a woman in Malaysia had a 1 in 20 chance of developing breast cancer in her lifetime. The incidence of cancer in general, and for breast cancer specifically was highest in the Chinese, followed by Indians and Malays. Most of the patients with breast cancers presented at late stages (stage I: 15.45%, stage II: 46.9%, stage III: 22.2% and stage IV: 15.5%). The Healthy Lifestyles Campaign which started in the early nineties had created awareness on breast cancer and after a decade the effort was enhanced with the Breast Health Awareness program to promote breast self examination (BSE) to all women, to perform annual clinical breast examination (CBE) on women above 40 and mammogram on women above 50. The National Health Morbidity Survey in 2006 showed that the prevalence rate of 70.35% by any of three methods of breast screening; 57.1% by BSE, 51.8% by CBE and 7.6% by mammogram. The current screening policy for breast cancer focuses on CBE whereby all women at the age of 20 years and above must undergo breast examination by trained health care providers every 3 years for age between 20-39 years, and annually for age 40 and above. Several breast cancer preventive programs had been developed by various ministries in Malaysia; among which are the RM50 subsidy for mammogram by the Ministry of Women, Family and Community Development and the SIPPS program (a call-recall system for women to do PAP smear and CBE) by the Ministry of Health. Measures to increase uptake of breast cancer screening and factors as to why women with breast cancer present late should be studied to assist in more development of policy on the prevention of breast cancer in Malaysia. PMID:22126511

  3. Chronic Inflammation in Cancer Development

    OpenAIRE

    Multhoff, Gabriele; Molls, Michael; Radons, Jürgen

    2012-01-01

    Chronic inflammatory mediators exert pleiotropic effects in the development of cancer. On the one hand, inflammation favors carcinogenesis, malignant transformation, tumor growth, invasion, and metastatic spread; on the other hand inflammation can stimulate immune effector mechanisms that might limit tumor growth. The link between cancer and inflammation depends on intrinsic and extrinsic pathways. Both pathways result in the activation of transcription factors such as NF-κB, STAT-3, and HIF-...

  4. Women's knowledge of and attitude toward breast cancer in a developing country: implications for program interventions--results based on interviewing 500 women in Saudi Arabia.

    Science.gov (United States)

    Ibrahim, E M; al-Idrissi, H Y; al-Khadra, A H; Kurashi, N Y; al-Jishi, F M; Saied, I; al-Mohana, F A; al-Shehabi, A F

    1991-01-01

    We interviewed 500 adult females without personal history of any type of cancer to assess their awareness and attitude toward various aspects of breast cancer. The mean age (SD) of participants was 31.6 (+/- 8.5) years with a range of 18 to 62 years. After control for level of education, age was not found to be a statistically significant factor that influenced participants' performance. Also not statistically significant was the history of having a relative who had cancer. Conversely, education was the only examined factor that correlated with interviewees' awareness and attitude. Individuals with university or higher education (level III) were more knowledgeable (statistically significant) than uneducated or those with only primary schooling (level I), or those participants who only had intermediate or high school education (level II). On the other hand, the responses of those individuals with education level I generally performed in a fashion similar to those at education level II. The general outcome of this exercise was that unacceptably high proportions of females at all education levels were either wrong or uncertain about some fundamental aspects of breast cancer etiology, risk factors, clinical features, detection methods, and management. Also shown was the relatively high percentages of those, particularly in education level I, who held misconceptions about unconventional management or the complications of conventional methods. We conclude that academic education alone is not enough to assure that recommended health behaviors will be adopted. For establishing cancer health education or cancer prevention and early detection programs, primary care physicians and community cancer centers should work jointly. Brief guidelines are proposed. PMID:1911173

  5. Integrative Medicine Program- MD Anderson Cancer Center

    Directory of Open Access Journals (Sweden)

    Richard T Lee

    2012-06-01

    Full Text Available The Integrative Medicine Program at MD Anderson Cancer Center was first established in 1998.  Our mission is to empower patients with cancer and their families to become active partners in their own physical, psycho-spiritual, and social health through personalized education and evidenced-based clinical care to optimize health, quality of life, and clinical outcomes across the cancer continuum.  The program consists of three main components: clinical care, research, and education.  The Integrative Medicine Center provides clinical services to patients through individual and group programs.  The clinical philosophy of the center is to work collaboratively with the oncology teams to build comprehensive and integrative care plans that are personalized, evidence-based, and safe with the goal of improving clinical outcomes.  The individual services comprise of integrative oncology consultation, acupuncture, meditation, music therapy, nutrition, and oncology massage.  The center also provides a variety of group programs including meditation, yoga, tai chi, cooking classes and others.  Over the past 13 years, over 70,000 patients and families have participated in services and programs offered by the center.  The research portfolio focuses on three main areas: mind-body interventions, acupuncture, and meditation.  This lecture will focus on providing an overview of the Integrative Medicine Program at MD Anderson with a focus on the clinical services provided.  Participants will learn about the integrative clinical model and how this is applied to the care of cancer patients at MD Anderson Cancer Center.  Current and future research topics will be discussed as well as patient cases.

  6. The bicalutamide Early Prostate Cancer Program. Demography

    DEFF Research Database (Denmark)

    See, W A.; McLeod, D; Iversen, P; Wirth, M

    2001-01-01

    areas (North America; Australia, Europe, Israel, South Africa and Mexico; and Scandinavia). Men with T1b-4N0-1M0 (TNM 1997) prostate cancer have been randomized on a 1:1 basis to receive bicalutamide 150 mg daily or placebo. Recruitment to the program closed in July 1998, and follow-up is ongoing. Study...

  7. Program development for SUPERFISH

    International Nuclear Information System (INIS)

    A new computer program is coded to calculate rf fields and resonant frequencies in axially symmetrical cavities. Algorithms for triangular mesh generation and finding the frequencies are the same as those in SUPERFISH, but the quadratic Lagrange interpolation is used to approximate the fields in triangular elements. The test runs are made for a pill-box cavity with the numbers of calculating mesh points which are equivalent to the cases for SUPERIFSH. Although noticeable improvements have not yet been obtained for the frequencies, the test runs have shown that the new program gives better accuracies for the field values than SUPERFISH

  8. Challenges for cancer vaccine development.

    Science.gov (United States)

    Tabi, Z; Man, S

    2006-10-01

    The first generation of human cancer vaccines has been tested in phase III clinical trials, but only a few of these have demonstrated sufficient efficacy to be licensed for clinical use. This article reviews some of the mechanisms that could contribute to these limited clinical responses, and highlights the challenges faced for development of future vaccines. PMID:16979786

  9. Phase 2 N01 Program - Cancer Imaging Program

    Science.gov (United States)

    The Phase 2 N01 Program is a CTEP-CIP collaboration includes 7 contractors, most of whom consist of multi-institutional consortia, and includes a total of 22 NCI-designated Cancer Centers. These sites carry out early clinical trials with CTEP and CIP-held IND agents, with an emphasis on phase 2 trials, but including phase 1 trials as well. These trials include the evaluation of novel imaging agents and methods to enhance the evaluation of novel therapeutics.

  10. Hereditary Colorectal Cancer (CRC Program in Latvia

    Directory of Open Access Journals (Sweden)

    Irmejs Arvids

    2003-12-01

    Full Text Available Abstract Introduction The aim of the study is to evaluate the incidence and phenotype - genotype characteristics of hereditary colorectal cancer syndromes in Latvia in order to develop the basis of clinical management for patients and their relatives affected by these syndromes. Materials and methods From 02/1999-09/2002 in several hospitals in Latvia cancer family histories were collected from 865 patients with CRC. In families suspected of having a history consistent with a hereditary colorectal cancer syndrome, DNA testing for MLH1, MSH2 and MSH6 genes was performed. In addition immunohistochemical (IH examination of the normal and cancer tissue from large bowel tumors for MSH2 and MSH6 protein expression was performed prior to DNA analysis. Results From the 865 CRC cases only 3 (0.35% pedigrees fulfilled the Amsterdam II criteria of Hereditary Nonpolyposis Colorectal Cancer (HNPCC and 15 cases (1.73% were suspected of HNPCC. In 69 cases (8% with a cancer family aggregation (CFA were identified. Thus far 27 IH analyses have been performed and in 3 cancers homogenous lack of MSH2 or MSH6 protein expression was found. In one of these cases a mutation in MSH6 was identified. In 18 patients suspected of HNPCC or of matching the Amsterdam II criteria, denaturing high performance liquid chromatography (DHPLC followed by DNA sequencing of any heteroduplexes of the 35 exons comprising both MLH1 and MSH2 was performed revealing 3 mutations. For all of kindreds diagnosed definitively or with a high probability of being an HNPCC family appropriate recommendations concerning prophylactic measures, surveillance and treatment were provided in written form. Conclusions Existing pedigree/clinical data suggest that in Latvia the frequency of HNPCC is around 2% of consecutive colorectal cancer patients. It is crucial that genetic counseling is an integral part of cancer family syndrome management.

  11. The Biodenitrification Development Program

    International Nuclear Information System (INIS)

    Oak Ridge National Laboratory (ORNL) conducted a pilot-plant program in support of the fluidized-bed biodenitrification system currently under construction by Westinghouse, Inc., at the Feed Materials Production Center (FMPC) in Fernald, Ohio. Two 0.1-m-diam bioreactors in series, each with ∼6.1 m of active bed height, and a single 12.2-m-high, 0.1-m-diam fluidized-bed bioreactor were operated to simulate the larger bioreactors (four 1.2-m-diam bioreactors each with 12.2 m of active bed height to be operated in series) under construction at Fernald. These pilot systems were used to verify the Fernald design as well as to identify and attempt to solve any problems that might affect the full-scale system. Results of studies with FMPC wastewater having nitrate levels as high as 10 g/L indicate that the Fernald bioreactors probably cannot operate on untreated wastewater because of its high calcium concentration. When the pilot-plant system was tested with raw wastewater having calcium concentrations ranging from 100 to 450 mg/L, the bioreactors ceased to function within 5 weeks after startup due to the buildup of calcium carbonate on the bioparticles. However, Fernald wastewater has been softened at ORNL and successfully biodenitrified. The results obtained to date indicate that the biodenitrification rate used in the design of the Fernald bioreactors, 32 kg (NO3-N)/d x m3, may be achieved or exceeded; however, pH adjustment within the bioreactors may be necessary. The temperature rise may be as high as 40C in each bioreactor due to the exothermic nature of the biodenitrification reaction. Under limiting adiabatic conditions, the overall temperature rise through four columns could be 15 to 200C. Thus, some kind of temperature control will probably be necessary to achieve optimal performance. 12 refs., 21 figs., 6 tabs

  12. IND Regulatory & Manufacturing Resources - Cancer Imaging Program

    Science.gov (United States)

    The Cancer Imaging Program has been creating Investigational New Drug Applications (IND) for imaging agents in order to engage in multi-center clinical trials of these materials. A subset of the documents filed is being made available to the research community to implement routine synthesis of tracers at their own facilities and to assist investigators with the filing of their own INDs. The first of these document sets is for F-18 fluorothymidine (FLT).

  13. NCG turbocompressor development program

    Energy Technology Data Exchange (ETDEWEB)

    Nichols, K.E.

    1997-12-31

    Barber-Nichols, Pacific Gas and Electric and UNOCAL as an industry group applied for a DOE grant under the GTO to develop a new type of compressor that could be used to extract non-condensable gas (NCG) from the condensers of geothermal power plants. This grant (DE-FG07-951A13391) was awarded on September 20, 1995. The installation and startup of the turbocompressor at the PG&E Geysers Unit 11 is covered by this paper. The turbocompressor has operated several days at 17000rpm while the plant was producing 50 to 70 MW.

  14. Development and Formative Evaluation of a Web-Based Self-Management Exercise and Diet Intervention Program With Tailored Motivation and Action Planning for Cancer Survivors

    OpenAIRE

    Lee, Myung Kyung; Park, Hyeoun-Ae; Yun, Young Ho; Chang, Yoon Jung

    2013-01-01

    Background Most dietary and exercise interventions developed to date for cancer survivors have employed intensive clinic-based face-to-face counseling sessions. However, when the clinic-based face-to-face intervention ends, the participants cannot receive feedback from the experts, and the motivation for regular exercise and diet practices decreases. One way to overcome the shortcomings of clinic-based face-to-face intervention is to employ the Internet to this end. To maximize effectiveness ...

  15. Wetland Program Development Grants (WPDGs)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Wetland Grant Database (WGD) houses grant data for Wetland Program Development Grants (created by EPA in 1990 under the Clean Water Act Section 104(b)(3)...

  16. Visualization program development using Java

    Energy Technology Data Exchange (ETDEWEB)

    Sasaki, Akira; Suto, Keiko [Japan Atomic Energy Research Inst., Kizu, Kyoto (Japan). Kansai Research Establishment; Yokota, Hisashi [Research Organization for Information Science and Technology, Tokai, Ibaraki (Japan)

    2002-03-01

    Method of visualization programs using Java for the PC with the graphical user interface (GUI) is discussed, and applied to the visualization and analysis of 1D and 2D data from experiments and numerical simulations. Based on an investigation of programming techniques such as drawing graphics and event driven program, example codes are provided in which GUI is implemented using the Abstract Window Toolkit (AWT). The marked advantage of Java comes from the inclusion of library routines for graphics and networking as its language specification, which enables ordinary scientific programmers to make interactive visualization a part of their simulation codes. Moreover, the Java programs are machine independent at the source level. Object oriented programming (OOP) methods used in Java programming will be useful for developing large scientific codes which includes number of modules with better maintenance ability. (author)

  17. Visualization program development using Java

    International Nuclear Information System (INIS)

    Method of visualization programs using Java for the PC with the graphical user interface (GUI) is discussed, and applied to the visualization and analysis of 1D and 2D data from experiments and numerical simulations. Based on an investigation of programming techniques such as drawing graphics and event driven program, example codes are provided in which GUI is implemented using the Abstract Window Toolkit (AWT). The marked advantage of Java comes from the inclusion of library routines for graphics and networking as its language specification, which enables ordinary scientific programmers to make interactive visualization a part of their simulation codes. Moreover, the Java programs are machine independent at the source level. Object oriented programming (OOP) methods used in Java programming will be useful for developing large scientific codes which includes number of modules with better maintenance ability. (author)

  18. Developing a Leadership Program Trajectory.

    Science.gov (United States)

    Bleich, Michael R

    2016-06-01

    From a program development perspective, leadership goals and content are best developed over time, with an aim to help nurses mature into their capacity to lead. Leadership often is encouraged in new nurses or in those who seek management positions. Professional development educators are encouraged to enact leadership development across a career continuum. J Contin Educ Nurs. 2016;47(6):250-252. PMID:27232221

  19. Geocoding and Social Marketing in Alabama’s Cancer Prevention Programs

    OpenAIRE

    Julianna W. Miner, MPH; Arica White, MPH; Anne E. Lubenow, MPH; Sally Palmer

    2005-01-01

    The Alabama Department of Public Health (ADPH) is collaborating with the National Cancer Institute to develop detailed profiles of underserved Alabama communities most at risk for cancer. These profiles will be combined with geocoded data to create a pilot project, Cancer Prevention for Alabama’s Underserved Populations: A Focused Approach. The project's objectives are to provide the ADPH's cancer prevention programs with a more accurate and cost-effective means of planning, implementing, and...

  20. NASA Procurement Career Development Program

    Science.gov (United States)

    1987-01-01

    The NASA Procurement Career Development Program establishes an agency-wide framework for the management of career development activity in the procurement field. Within this framework, installations are encouraged to modify the various components to meet installation-specific mission and organization requirements. This program provides a systematic process for the assessment of and planning for the development, training, and education required to increase the employees' competence in the procurement work functions. It includes the agency-wide basic knowledge and skills by career field and level upon which individual and organizational development plans are developed. Also, it provides a system that is compatible with other human resource management and development systems, processes, and activities. The compatibility and linkage are important in fostering the dual responsibility of the individual and the organization in the career development process.

  1. Innovative Program Aims to Improve Support for Cancer Family Caregivers

    Science.gov (United States)

    An article about an educational program at the City of Hope Cancer Center intended to provide health professionals with the tools and information needed to help family caregivers care for themselves and their loved ones with cancer.

  2. Environmental Education and Development Program

    Energy Technology Data Exchange (ETDEWEB)

    1994-03-01

    The Environmental Education and Development Program is a component on the effort to accomplish the Office of Environmental Restoration and Waste Management`s (EM) goal of environmental compliance and cleanup of the 1989 inventory of inactive DOE sites and facilities by the year 2019. Education and Development programs were designed specifically to stimulate the knowledge and workforce capability necessary to achieve EM goals while contributing to DOE`s overall goal of increasing scientific and technical literacy and competency. The primary implementation criterion for E&D activities involved a focus on programs and projects that had both immediate and long-range leveraging effects on infrastructure. This focus included programs that yielded short term results (one to five years), as well as long-term results, to ensure a steady supply of appropriately trained and educated human resources, including women and minorities, to meet EM`s demands.

  3. Research and development program 1985

    International Nuclear Information System (INIS)

    In this report the research and development program of the GSI Darmstadt is described. It concerns heavy ion reactions, nuclear structure studies, exotic nuclei, nuclear theory, atomic collisions with heavy ions, atomic spectroscopy, the interaction of heavy ions with matter, atomic theory, biological studies with heavy ions, nuclear track techniques, UNILAC developments, acquisition of experimental data, and the development of new accelerators, ion sources, targets, and detectors. (HSI)

  4. Pilot Implementation of Breast Cancer Early Detection Programs in Colombia

    OpenAIRE

    Murillo, Raúl; Díaz, Sandra; Sánchez, Oswaldo; Perry, Fernando; Piñeros, Marion; Poveda, César; Salguero, Edgar; Osorio, Dimelza

    2008-01-01

    Breast cancer is increasing in developing countries, and Colombia has a double burden from cervical and breast cancer. Suitable guidelines for breast cancer early detection are needed, and the Breast Health Global Initiative provides a favorable framework for breast cancer control in low resource nations. The Colombian National Cancer Institute developed evidence-based guidelines for breast cancer early detection in which coordinated early detection in symptomatic women and hospital-based scr...

  5. Cancer Treatment-Related Cardiotoxicity: Understanding the Current State of Knowledge and Developing Future Research Priorities

    Science.gov (United States)

    Cancer Treatment-Related Cardiotoxicity: Understanding the Current State of Knowledge and Developing Future Research Priorities, a 2013 workshop sponsored by the Epidemiology and Genomics Research Program.

  6. Patient-Centered Cancer Care Programs in Italy: Benchmarking Global Patient Education Initiatives.

    Science.gov (United States)

    Truccolo, Ivana; Cipolat Mis, Chiara; Cervo, Silvia; Dal Maso, Luigino; Bongiovanni, Marilena; Bearz, Alessandra; Sartor, Ivana; Baldo, Paolo; Ferrarin, Emanuela; Fratino, Lucia; Mascarin, Maurizio; Roncadin, Mario; Annunziata, Maria Antonietta; Muzzatti, Barbara; De Paoli, Paolo

    2016-06-01

    In Italy, educational programs for cancer patients are currently provided by the national government, scientific societies, and patient advocate organizations. Several gaps limit their effectiveness, including the lack of coordinated efforts, poor involvement of patient feedback in the planning of programs, as well as a lack of resources on innovative cancer-related topics. This process is parallel to a strong shift in the attitude of patients towards health in general and taking charge of their own health conditions in particular. The National Cancer Institute in the USA and the Organization of European Cancer Institutes encourage comprehensive cancer centers in providing educational programs conceived to overcome these gaps. The goal of this paper is to identify and describe the key elements necessary to develop a global patient education program and provide recommendations for strategies with practical examples for implementation in the daily activities of cancer institutes. A multidisciplinary committee was established for patient education, including patient representatives as equal partners, to define, implement, verify, and evaluate the fundamental steps for establishing a comprehensive education program. Six essential topics were identified for the program: appropriate communication of cancer epidemiology, clinical trial information, new therapeutic technologies, support in the use of medicines, psycho-oncological interventions, age-personalized approaches, and training programs for healthcare providers. Integration of these topics along with patient feedback is the key to a successful model for educational programs. An integrated educational program can transform a comprehensive cancer center to an institution that provides research and care for and with patients. PMID:25773134

  7. Population-level scale-up of cervical cancer prevention services in a low-resource setting: development, implementation, and evaluation of the cervical cancer prevention program in Zambia.

    Directory of Open Access Journals (Sweden)

    Groesbeck P Parham

    Full Text Available Very few efforts have been undertaken to scale-up low-cost approaches to cervical cancer prevention in low-resource countries.In a public sector cervical cancer prevention program in Zambia, nurses provided visual-inspection with acetic acid (VIA and cryotherapy in clinics co-housed with HIV/AIDS programs, and referred women with complex lesions for histopathologic evaluation. Low-cost technological adaptations were deployed for improving VIA detection, facilitating expert physician opinion, and ensuring quality assurance. Key process and outcome indicators were derived by analyzing electronic medical records to evaluate program expansion efforts.Between 2006-2013, screening services were expanded from 2 to 12 clinics in Lusaka, the most-populous province in Zambia, through which 102,942 women were screened. The majority (71.7% were in the target age-range of 25-49 years; 28% were HIV-positive. Out of 101,867 with evaluable data, 20,419 (20% were VIA positive, of whom 11,508 (56.4% were treated with cryotherapy, and 8,911 (43.6% were referred for histopathologic evaluation. Most women (87%, 86,301 of 98,961 evaluable received same-day services (including 5% undergoing same-visit cryotherapy and 82% screening VIA-negative. The proportion of women with cervical intraepithelial neoplasia grade 2 and worse (CIN2+ among those referred for histopathologic evaluation was 44.1% (1,735/3,938 with histopathology results. Detection rates for CIN2+ and invasive cervical cancer were 17 and 7 per 1,000 women screened, respectively. Women with HIV were more likely to screen positive, to be referred for histopathologic evaluation, and to have cervical precancer and cancer than HIV-negative women.We creatively disrupted the 'no screening' status quo prevailing in Zambia and addressed the heavy burden of cervical disease among previously unscreened women by establishing and scaling-up public-sector screening and treatment services at a population level. Key

  8. Development of watershed compensation programs

    International Nuclear Information System (INIS)

    British Columbia Hydro is developing fish and wildlife watershed compensation programs to address water license requirements of recent hydroelectric developments and outstanding issues associated with older projects. Historically, no funding was provided for environmental impacts. In more recent times, a one-time payment was made to the appropriate government agencies. With no long-term commitment by B.C. Hydro, fish and wildlife resource needs were often not addressed, leading to the degradation or loss of the resource and the perception that B.C. Hydro was not addressing its responsibilities with respect to other water users. B.C. Hydro's activities are reviewed with respect to developing ongoing fisheries compensation or mitigation programs through trust funds that ensure a long term commitment towards replacing or improving, and maintaining fish resources associated with B.C. Hydro's hydroelectric developments. 2 figs

  9. Hydropower Development Programming in China

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    In the light of the speech delivered by Mr.Zhou Dabing,Deputy Manager General of China National Electric Power Corporation,on its hosted “Hydropower Developing Seminar”, during the national “10th Fivc-ynar Plan” and the “Farsight Program to 2015”, the installed capacity of hydropower shall be up to 75GW by 2000,

  10. Professorship: A Faculty Development Program.

    Science.gov (United States)

    Davis, Todd M.; Davis, Jane F.

    1987-01-01

    A faculty development program at a traditionally black college was designed to enhance the ability of graduate faculty to supervise research activities of graduate students. Focus was on interpersonal problem solving in advisement and professional issues; classroom techniques of discussion teaching, case methods, and psychodrama encouraged the…

  11. Cooperative research and development opportunities with the National Cancer Institute

    Science.gov (United States)

    Sybert, Kathleen

    1991-01-01

    The Office of Technology Development (OTD) of the National Cancer Institute (NCI) is responsible for negotiating Cooperative Research and Development Agreements (CRADAs), whereby the knowledge resulting from NCI investigators' government-sponsored research is developed in collaboration with universities and/or industry into new products of importance for the diagnosis and treatment of cancer and acquired immunodeficiency syndrome (AIDS). The NCI has recently executed a unique 'clinical trials' CRADA and is developing a model agreement based upon it for the development and commercialization of products for the diagnosis and treatment of cancer and AIDS. NCI drug screening, preclinical testing, clinical trials, and AIDS program capabilities form the basis for this new technology development/technology transfer vehicle. NCI's extensive drug screening program and 'designer foods' program serve as potential sources of investigational new drugs (INDs) and cancer preventatives. Collaborations between NCI and pharmaceutical companies having the facilities, experience, and expertise necessary to develop INDs into approved drugs available to the public are being encouraged where the companies have proprietary rights to INDs, or where NCI has proprietary rights to INDs and invites companies to respond to a collaborator announcement published in the Federal Register. The joint efforts of the NCI and the chosen collaborator are designed to generate the data necessary to obtain pharmaceutic regulatory approval from the Food and Drug Administration (FDA) to market the drugs developed, and thereby make them available to health care providers for the diagnosis and treatment of cancer and AIDS.

  12. Chemoprevention of Skin Cancer Program Project | Division of Cancer Prevention

    Science.gov (United States)

    DESCRIPTION (provided by applicant): Skin cancer is the most common malignancy in the world. One out of three new cancers is a skin cancer. More than 1 million cases of non-melanoma skin cancer (NMSC) (basal cell carcinoma [BCC] and squamous cell cancers [SCC]) occur annually. While the incidence rates for non-melanoma skin cancers continue to rise, there continues to be a substantial impact on morbidity, health and health care costs. |

  13. Feature Selection and Molecular Classification of Cancer Using Genetic Programming

    Directory of Open Access Journals (Sweden)

    Jianjun Yu

    2007-04-01

    Full Text Available Despite important advances in microarray-based molecular classification of tumors, its application in clinical settings remains formidable. This is in part due to the limitation of current analysis programs in discovering robust biomarkers and developing classifiers with a practical set of genes. Genetic programming (GP is a type of machine learning technique that uses evolutionary algorithm to simulate natural selection as well as population dynamics, hence leading to simple and comprehensible classifiers. Here we applied GP to cancer expression profiling data to select feature genes and build molecular classifiers by mathematical integration of these genes. Analysis of thousands of GP classifiers generated for a prostate cancer data set revealed repetitive use of a set of highly discriminative feature genes, many of which are known to be disease associated. GP classifiers often comprise five or less genes and successfully predict cancer types and subtypes. More importantly, GP classifiers generated in one study are able to predict samples from an independent study, which may have used different microarray platforms. In addition, GP yielded classification accuracy better than or similar to conventional classification methods. Furthermore, the mathematical expression of GP classifiers provides insights into relationships between classifier genes. Taken together, our results demonstrate that GP may be valuable for generating effective classifiers containing a practical set of genes for diagnostic/ prognostic cancer classification.

  14. Research and development program, fiscal year 1970

    Energy Technology Data Exchange (ETDEWEB)

    1968-04-01

    The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for FY 1970 is conducted within the scope of the following categories: Somatic Effects of Radiation; Combating Detrimental Effects of Radiation; Molecular and Cellular Level Studies; Environmental Radiation Studies; Radiological and Health Physics and Instrumentation; Cancer Research; and Selected Beneficial Applications. The overall objectives of the Laboratory within these areas of the Biology and Medicine Program may be summarized as follows: (1) investigation of the effects of ionizing radiation on systems of biological significance and on living organisms; (2) assessment and study of the immediate and long term consequences of the environmental radioactivity on flora, fauna, and man; (3) development of beneficial uses of ionizing radiation and radioactive substances in medicine and biology; and (4) the conduct of training and educational activities in fields related to the biological and medical aspects of radiation.

  15. Developing cancer warning statements for alcoholic beverages

    OpenAIRE

    Pettigrew, Simone; Jongenelis, Michelle; Chikritzhs, Tanya; Slevin, Terry; Pratt, Iain S; Glance, David; Liang, Wenbin

    2014-01-01

    Background There is growing evidence of the increased cancer risk associated with alcohol consumption, but this is not well understood by the general public. This study investigated the acceptability among drinkers of cancer warning statements for alcoholic beverages. Methods Six focus groups were conducted with Australian drinkers to develop a series of cancer-related warning statements for alcohol products. Eleven cancer warning statements and one general health warning statement were subse...

  16. NCI Community Oncology Research Program Approved | Division of Cancer Prevention

    Science.gov (United States)

    On June 24, 2013, the National Cancer Institute (NCI) Board of Scientific Advisors approved the creation of the NCI Community Oncology Research Program (NCORP). NCORP will bring state-of-the art cancer prevention, control, treatment and imaging clinical trials, cancer care delivery research, and disparities studies to individuals in their own communities. |

  17. Cancer Prevention Fellowship Program | Division of Cancer Prevention

    Science.gov (United States)

    The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

  18. How to motivate developers to pair program?

    OpenAIRE

    Haara, Johanna

    2016-01-01

    Many developers are needed to develop large software. Successful development demands communication and teamwork and pair programming improves them. One practice of Extreme Programming is pair programming, which means that developers work together a task. This case study studied how to motivate developers to pair program. The benefits, cost and ways to pair program were studied. In addition, affect of general motivation and Belbin’s team roles to pair programming were studied. The study w...

  19. Glucocorticoid programming of intrauterine development.

    Science.gov (United States)

    Fowden, A L; Valenzuela, O A; Vaughan, O R; Jellyman, J K; Forhead, A J

    2016-07-01

    Glucocorticoids (GCs) are important environmental and maturational signals during intrauterine development. Toward term, the maturational rise in fetal glucocorticoid receptor concentrations decreases fetal growth and induces differentiation of key tissues essential for neonatal survival. When cortisol levels rise earlier in gestation as a result of suboptimal conditions for fetal growth, the switch from tissue accretion to differentiation is initiated prematurely, which alters the phenotype that develops from the genotype inherited at conception. Although this improves the chances of survival should delivery occur, it also has functional consequences for the offspring long after birth. Glucocorticoids are, therefore, also programming signals that permanently alter tissue structure and function during intrauterine development to optimize offspring fitness. However, if the postnatal environmental conditions differ from those signaled in utero, the phenotypical outcome of early-life glucocorticoid receptor overexposure may become maladaptive and lead to physiological dysfunction in the adult. This review focuses on the role of GCs in developmental programming, primarily in farm species. It examines the factors influencing GC bioavailability in utero and the effects that GCs have on the development of fetal tissues and organ systems, both at term and earlier in gestation. It also discusses the windows of susceptibility to GC overexposure in early life together with the molecular mechanisms and long-term consequences of GC programming with particular emphasis on the cardiovascular, metabolic, and endocrine phenotype of the offspring. PMID:27345310

  20. Building a funded research program in cancer health disparities: considerations for young investigators

    OpenAIRE

    Heather M. Ochs-Balcom; Phillips, Lynette S.; Nichols, Hazel B.; Martinez, Elena; Thompson, Beti; Ojeifo, John; Rebbeck, Timothy R.

    2015-01-01

    A workshop entitled “Building a funded research program in cancer health disparities” was held at the 38th Annual American Society of Preventive Oncology (ASPO) Meeting. Organized by the Junior Members Interest Group, the session addressed topics relevant to career development for cancer disparities investigators. Such considerations include the development of research programs on a backdrop of existing multi- and trans-disciplinary teams, recognizing opportunities for advancing their researc...

  1. Program Development and Evaluation - Education / Program Design

    OpenAIRE

    2004-01-01

    Susan Barkman: Evaluation Made Easy – Designing Instruments to Measure Program Impact. Cassandra S. Corridon: Meeting the Needs of Our Audience: Child Care Connections. Jerry Culen: Assessing Environmental Literacy in a 4-H Program. Ken Culp III: University of Kentucky Volunteer Administration Academy. Louise E. Davis: Mississippi’s Goal of Improving Quality Childcare in Unlicensed Settings. Theresa M. Ferrari: Hours of Opportunity or Hours of Risk. Martha S. Garton: Does a Week Long 4-H Cam...

  2. Advanced Emissions Control Development Program

    Energy Technology Data Exchange (ETDEWEB)

    A.P.Evans; K.E. Redinger; M.J. Holmes

    1998-04-01

    The objective of the Advanced Emissions Control Development Program (AECDP) is to develop practical, cost-effective strategies for reducing the emissions of air toxics from coal-fired boilers. Ideally, the project aim is to effectively control air toxic emissions through the use of conventional flue gas cleanup equipment such as electrostatic precipitators (ESPS), fabric filters (baghouse), and wet flue gas desulfurization. Development work to date has concentrated on the capture of mercury, other trace metals, fine particulate and hydrogen chloride. Following the construction and evaluation of a representative air toxics test facility in Phase I, Phase II focused on the evaluation of mercury and several other air toxics emissions. The AECDP is jointly funded by the United States Department of Energy's Federal Energy Technology Center (DOE), the Ohio Coal Development Office within the Ohio Department of Development (oCDO), and Babcock& Wilcox-a McDermott company (B&W).

  3. "I Am More than My Cancer": An Exploratory Examination of Adventure Programming and Cancer Survivors

    Science.gov (United States)

    Sugerman, Deborah

    2005-01-01

    Adventure programs have recently emerged that are specifically designed for individuals living with cancer, yet few research studies document the outcomes of such programs. The purpose of the current qualitative study was to examine the effects of an adventure program on individual adult cancer survivors. Three central themes emerged from the…

  4. Importance of Smoking Cessation in a Lung Cancer Screening Program

    OpenAIRE

    Munshi, Vidit; McMahon, Pamela

    2013-01-01

    Early detection of lung cancer and smoking cessation interventions can decrease lung cancer mortality, but information on the effectiveness and interaction between smoking cessation and lung cancer screening is sparse and inconsistent. This review aims to synthesize recent studies in two major areas of interest. First, we explore the interactions and potential for synergies between lung cancer screening programs and smoking cessation by summarizing reported changes in smoking behavior observe...

  5. Wind Energy Career Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Gwen Andersen

    2012-03-29

    Saint Francis University has developed curriculum in engineering and in business that is meeting the needs of students and employers (Task 1) as well as integrating wind energy throughout the curriculum. Through a variety of approaches, the University engaged in public outreach and education that reached over 2,000 people annually (Task 2). We have demonstrated, through the success of these programs, that students are eager to prepare for emerging jobs in alternative energy, that employers are willing to assist in developing employees who understand the broader business and policy context of the industry, and that people want to learn about wind energy.

  6. Culturally Competent Training Program: A Key to Training Lay Health Advisors for Promoting Breast Cancer Screening

    Science.gov (United States)

    Yu, Mei-yu; Song, Lixin; Seetoo, Amy; Cai, Cuijuan; Smith, Gary; Oakley, Deborah

    2007-01-01

    The lay health advisor (LHA) training program for breast cancer screening was conducted among Chinese-English bilingual trainees residing in Southeast Michigan. Guided by Bandura's Social Learning Theory, the development of the training curriculum followed the health communication process recommended by the National Cancer Institute. Data analysis…

  7. Screening history in women with cervical cancer in a Danish population-based screening program

    DEFF Research Database (Denmark)

    Kirschner, Benny; Poll, Susanne; Rygaard, Carsten;

    2011-01-01

    The aim of this study was to explore the screening histories of all cervical cancers in a Danish screening population. The intention was to decide suboptimal sides of the screening program and to evaluate the significance of routine screening in the development of cervical cancer....

  8. Progress and controversies in developing cancer vaccines

    Directory of Open Access Journals (Sweden)

    Speiser Daniel E

    2005-04-01

    Full Text Available Abstract Immunotherapy has become a standard approach for cancer management, through the use of cytokines (eg: interleukin-2 and monoclonal antibodies. Cancer vaccines hold promise as another form of immunotherapy, and there has been substantial progress in identifying shared antigens recognized by T cells, in developing vaccine approaches that induce antigen-specific T cell responses in cancer patients, and in developing new technology for monitoring immune responses in various human tissue compartments. Dramatic clinical regressions of human solid tumors have occurred with some cancer vaccines, but the rate of those responses remains low. This article is part of a 2-part point:counterpoint series on peptide vaccines and adoptive therapy approaches for cancer. The current status of cancer vaccination, and associated challenges, are discussed. Emphasis is placed on the need to increase our knowledge of cancer immunobiology, as well as to improve monitoring of cellular immune function after vaccination. Progress in both areas will facilitate development of effective cancer vaccines, as well as of adoptive therapy. Effective cancer vaccines promise to be useful for treatment and prevention of cancer at low cost and with low morbidity.

  9. Program development fund: FY 1987

    Energy Technology Data Exchange (ETDEWEB)

    1989-03-01

    It is the objective of the Fund to encourage innovative research to maintain the Laboratory's position at the forefront of science. Funds are used to explore new ideas and concepts that may potentially develop into new directions of research for the Laboratory and that are consistent with the major needs, overall goals, and mission of the Laboratory and the DOE. The types of projects eligible for support from PDF include: work in forefront areas of science and technology for the primary purpose of enriching Laboratory research and development capabilities; advanced study of new hypotheses, new experimental concepts, or innovative approaches to energy problems; experiments directed toward ''proof of principle'' or early determination of the utility of a new concept; and conception, design analyses, and development of experimental devices, instruments, or components. This report is a review of these research programs.

  10. Establishing and Sustaining a Prospective Screening Program for Breast Cancer-Related Lymphedema at the Massachusetts General Hospital: Lessons Learned

    OpenAIRE

    Brunelle, Cheryl; Skolny, Melissa; Ferguson, Chantal; Swaroop, Meyha; O’Toole, Jean; Taghian, Alphonse G.

    2015-01-01

    There has been an increasing call to prospectively screen patients with breast cancer for the development of breast cancer-related lymphedema (BCRL) following their breast cancer treatment. While the components of a prospective screening program have been published, some centers struggle with how to initiate, establish, and sustain a screening program of their own. The intent of this manuscript is to share our experience and struggles in establishing a prospective surveillance program within ...

  11. Program summary for the Civilian Reactor Development Program

    Energy Technology Data Exchange (ETDEWEB)

    None

    1982-07-01

    This Civilian Reactor Development Program document has the prime purpose of summarizing the technical programs supported by the FY 1983 budget request. This section provides a statement of the overall program objectives and a general program overview. Section II presents the technical programs in a format intended to show logical technical interrelationships, and does not necessarily follow the structure of the formal budget presentation. Section III presents the technical organization and management structure of the program.

  12. Program summary for the Civilian Reactor Development Program

    International Nuclear Information System (INIS)

    This Civilian Reactor Development Program document has the prime purpose of summarizing the technical programs supported by the FY 1983 budget request. This section provides a statement of the overall program objectives and a general program overview. Section II presents the technical programs in a format intended to show logical technical interrelationships, and does not necessarily follow the structure of the formal budget presentation. Section III presents the technical organization and management structure of the program

  13. Geocoding and Social Marketing in Alabama’s Cancer Prevention Programs

    Directory of Open Access Journals (Sweden)

    Julianna W. Miner, MPH

    2005-11-01

    Full Text Available The Alabama Department of Public Health (ADPH is collaborating with the National Cancer Institute to develop detailed profiles of underserved Alabama communities most at risk for cancer. These profiles will be combined with geocoded data to create a pilot project, Cancer Prevention for Alabama’s Underserved Populations: A Focused Approach. The project's objectives are to provide the ADPH's cancer prevention programs with a more accurate and cost-effective means of planning, implementing, and evaluating its prevention activities in an outcomes-oriented and population-appropriate manner. The project links geocoded data from the Alabama Statewide Cancer Registry with profiles generated by the National Cancer Institute’s cancer profiling system, Consumer Health Profiles. These profiles have been successfully applied to market-focused cancer prevention messages across the United States. The ADPH and the National Cancer Institute will evaluate the efficacy of using geocoded data and lifestyle segmentation information in strategy development and program implementation. Alabama is the first state in the nation not only to link geocoded cancer registry data with lifestyle segmentation data but also to use the National Cancer Institute’s profiles and methodology in combination with actual state data.

  14. 23 CFR 660.109 - Program development.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Program development. 660.109 Section 660.109 Highways... PROGRAMS (DIRECT FEDERAL) Forest Highways § 660.109 Program development. (a) The FHWA will arrange and... program will be selected considering the following criteria: (1) The development, utilization,...

  15. Developing the basic elements for breast diagnostic programs In Ghana

    International Nuclear Information System (INIS)

    Breast cancer is the most common cancer affecting women worldwide. Women are at an increase risk of developing both physical and psychological morbidity after diagnosis. Findings show that women who were diagnosed with breast cancer are at risk of developing several psychological morbidities such as depression, anxiety, fatigue, negative thoughts, suicidal thoughts, fear of dying, sense of aloneness, sexual and body image problems, as well as an overall decrease in the quality of life. The objective of this project is to review the available literature on breast cancer diagnostic programs in the developed world and the developing countries and develop one for Ghana. Lack of resources and basic infrastructure and data on breast cancer cases, make it difficult to have access to breast cancer screening, early diagnosis, treatment or palliative care. In all the studies reviewed, a trial population of about ten thousand women aging between 50-70 years were used for three years period. Mammography, Clinical Breast-Examination (CBE) and Breast Self-Examination (BSE) methods were used to screen the women. Assessment, biopsies and treatment of palpable screen-detected abnormalities were performed using Fine Needle aspiration (FNA) and fine needle aspiration cytology (FNAC). High-quality single medio-lateral oblique view mammography has been shown to be an effective method in reducing mortality from breast cancer and we conclude that initially this preferred option for the development of breast diagnostic program. There is no evidence that clinical breast-examination or breast self-examination is effective when used alone. These methods have some value when used in combination with mammography, but their contribution requires further assessment. From available data, and the cost involved in some trials conducted in some of the developed countries, the Ghanaian programme should be based on creation of public awareness about breast cancer disease. (author)

  16. The National Cancer Program: Driving Discovery

    Science.gov (United States)

    An overview of NCI’s role in driving cancer research discoveries: conducting and funding research in challenging areas and providing resources and leadership to national infrastructures for cancer research.

  17. Prevention program of cervical cancer - Enrique Pouey

    International Nuclear Information System (INIS)

    This work is about the first basic objectives in the prevention of cervical cancer in Uruguay. The Papanicolaou test, the biopsia, and the colposcopy are important studies for the early cervical cancer detection

  18. Radiology Network (ACRIN) - Cancer Imaging Program

    Science.gov (United States)

    ACRIN is funded to improve the quality and utility of imaging in cancer research and cancer care through expert, multi-institutional clinical evaluation of discoveries and technological innovations relevant to imaging science as applied in clinical oncology.

  19. Research and development program, fiscal year 1966

    Energy Technology Data Exchange (ETDEWEB)

    1964-04-01

    The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for FY 1966 is conducted within the scope of the following categories: Somatic Effects of Radiation; Combating Detrimental Effects of Radiation; Molecular and Cellular Level Studies; Environmental Radiation Studies; Radiological and Health Physics and Instrumentation; Chemical Toxicity; Cancer Research; and Selected Beneficial Applications. The overall objectives of the Laboratory within these areas of the Biology and Medicine program may be summarized as follows: (1) investigation of the effects of ionizing radiation on living organisms and systems of biological significance; (2) investigation of the dynamic aspects of physiological and biochemical processes in man, animals and plants and how these processes are modified by radiation and related pathological states; (3) the assessment and study of the immediate and long term consequences of the operation or detonation of nuclear devices on the fauna, and flora in man's environment and on man; (4) the development of methods of minimizing or preventing the detrimental effects of ionizing radiation; (5) research in, and development of, beneficial uses of ionizing radiation and radioactive substances in medicine and biology; (6) research in the development of new and more efficient radiation detection devices; (7) research, including field studies, as mutually agreed upon by the Commission and the University, in connection with the conduct of weapon tests and biomedical and civil effects experiments at such tests conducted at continental and overseas test sites; and (8) the conduct of training and educational activities in the biological and medical aspects of radiation and related fields.

  20. Thoria powder process development (LWBR Development Program)

    International Nuclear Information System (INIS)

    The development program to identify the critical parameters for the process of converting thorium nitrate solution into thoria powder is described. Thorium oxalate hexahydrate is precipitated from the reaction of thorium nitrate solution with oxalic acid. The resulting thorium oxalate hexahydrate slurry is filter pressed into a cake which is air calcined to form thoria powder. Changes in the critical processing parameters such as free nitric acid content of the thorium nitrate solution, precipitation temperature, and calcining temperature altered the thoria powder characteristics, and thus its capability for being fabricated into fuel pellets. The objective of the powder preparation effort was to obtain thoria powders which could be formed by conventional ceramic fabrication techniques into thoria and thoria-urania pellets of high density and high integrity having a nearly uniform large grain structure

  1. Uterine development and endometrial programming.

    Science.gov (United States)

    Bartol, F F; Wiley, A A; Bagnell, C A

    2006-01-01

    Structural patterning and functional programming of uterine tissues are mechanistically coupled. These processes ensure anteroposterior differentiation of uterine tissues from adjacent segments of the developing female reproductive tract (FRT) and radial patterning that establishes uterine-specific histoarchitecture and functionality. Uterine organogenesis begins prenatally and is completed postnatally. Genes required for FRT development include Pax2, Lim1 and Emx2, genes in the abdominal-B Hoxa cluster, and members of both Wnt and Hedgehog (Hh) gene families. Disruption of morphoregulatory gene expression patterns can prevent FRT development entirely or compromise uterine organogenesis specifically. Oestrogen receptor-alpha (ER) -dependent events associated with development of the neonatal porcine uterus can be altered by administration of oestrogen (E) or relaxin (RLX). Expression of the RLX receptor is detectable in porcine endometrium at birth, before onset of ER expression and uterine gland genesis. Uterotrophic effects of both E and RLX can be inhibited with the ER antagonist ICl 182,780, indicating that RLX may act via crosstalk with the ER system in neonatal tissues. Exposure of neonatal gilts to E alters temporospatial patterns of Hh, Wnt and Hoxa expression in the uterine wall. Oestrogen given for two weeks from birth produced hypoplastic adult porcine uteri that were less responsive to periattachment conceptus signals as reflected by reduced growth response and luminal fluid protein accumulation, altered endometrial gene expression, and reduced capacity for conceptus support. Data reinforce the concept that factors affecting signalling events in uterine tissues that produce changes in morphoregulatory gene expression patterns during critical organisational periods can alter the developmental trajectory of the uterus with lasting consequences. Thus, uterine tissues can be programmed epigenetically for success or failure during perinatal life. PMID

  2. Oral cancer in Libya and development of regional oral cancer registries: A review.

    Science.gov (United States)

    BenNasir, E; El Mistiri, M; McGowan, R; Katz, R V

    2015-10-01

    The aims of this paper are three-fold: (1) to summarize the current epidemiological data on oral cancer in Libya as reported in the published literature and as compared to other national oral cancer rates in the region; (2) to present both the history of the early development, and future goals, of population-based oral cancer tumor registries in Libya as they partner with the more established regional and international population-based cancer tumor registries; and, (3) to offer recommendations that will likely be required in the near future if these nascent, population-based Libyan oral cancer registries are to establish themselves as on-going registries for describing the oral cancer disease patterns and risk factors in Libya as well as for prevention and treatment. This comprehensive literature review revealed that the current baseline incidence of oral cancer in Libya is similar to those of other North Africa countries and China, but is relatively low compared to the United Kingdom, the United States, and India. The recently established Libyan National Cancer Registry Program, initiated in 2007, while envisioning five cooperating regional cancer registries, continues to operate at a relatively suboptimal level. Lack of adequate levels of national funding continue to plague its development…and the accompanying quality of service that could be provided to the Libyan people. PMID:26644751

  3. BE ACTIVE: an Education Program for Chinese Cancer Survivors in Canada.

    Science.gov (United States)

    Kwong, Sandy; Bedard, Angela

    2016-09-01

    The needs of cancer survivors have been well documented and tend to be higher in immigrant populations. In order to help address unmet needs of Chinese-speaking cancer survivors, we have developed a structured psycho-educational program for this group. The program development was informed by both cultural values of the population and published recommendations for cancer survivorship education and support. The program, entitled BE ACTIVE, includes topics related to key domains in cancer survivorship: psychosocial aspects, general medical management and follow up for late effects, complementary medicine, and lifestyle management through fitness and nutrition. We studied the program delivery in 2012 and 2013, where a total of 124 individuals took part. Participants reported high satisfaction, learning gains, and the willingness to recommend the program to others; they rated their understanding of the behaviors needed for wellness and their motivation for change as high. A facilitator toolkit, which includes topic content development guides and presentation examples, was developed to assist with delivery of the program by other centers. This type of program can improve access and delivery to underserved populations with unmet needs and may also benefit cancer survivors in other jurisdictions with similar concerns. PMID:26386593

  4. Developing a career advancement program.

    Science.gov (United States)

    Pinette, Shirley L

    2003-01-01

    Have you ever asked yourself, "What will I be doing five or ten years from now?" "Will I be doing the same thing I'm doing right now?" How would you feel if the answer were "yes"? I often wonder if any of my employees think the same thing. If they do, and the answer is "yes," just how does that make them feel? A day's work for managers can run the gamut--from billing and coding, to patient issues, to staff performance reviews, to CQI, to JCAHO-just to name a few. We're NEVER bored. Can we say the same of our employees, or do they do the same thing day in and day out? If so, it's no wonder that attitudes may become negative and motivation and productivity may decline. What are we as healthcare managers and administrators doing to value and continually train our employees so that staff morale, productivity and patient satisfaction remain high? What are we doing to keep those highly motivated employees motivated and challenged so that they don't get bored and want to move across town to our neighboring hospital or healthcare center? What are we doing to stop our employees from developing the "same job, different day" attitude? A Career Ladder program holds many benefits and opportunities for the motivated employee who seeks and needs additional challenges on the job. It affords them opportunities to learn new skills, demonstrate initiative, accept additional responsibilities and possibly advance into new positions. It also affords them opportunities to grow, to be challenged and to feel like an important and valued member of the radiology team and radiology department. For the manager, a Career Ladder program affords opportunities to retain valuable employees, attract new high-quality employees and maintain a workforce of well-trained highly motivated employees, which in turn will provide high quality products and services to our customers. A Career Ladder program is a "win-win" situation for everyone. For the last twelve months, I have been working with other

  5. Cancer Incidence in Egypt: Results of the National Population-Based Cancer Registry Program

    OpenAIRE

    Amal S. Ibrahim; Khaled, Hussein M.; Nabiel NH Mikhail; Hoda Baraka; Hossam Kamel

    2014-01-01

    Background. This paper aims to present cancer incidence rates at national and regional level of Egypt, based upon results of National Cancer Registry Program (NCRP). Methods. NCRP stratified Egypt into 3 geographical strata: lower, middle, and upper. One governorate represented each region. Abstractors collected data from medical records of cancer centers, national tertiary care institutions, Health Insurance Organization, Government-Subsidized Treatment Program, and death records. Data ...

  6. Conductive spacecraft materials development program

    Science.gov (United States)

    Lehn, W. L.

    1977-01-01

    The objectives of this program are to provide design criteria, techniques, materials, and test methods to ensure control of absolute and differential charging of spacecraft surfaces. The control of absolute and differential charging of spacecraft cannot be effected without the development of new and improved or modified materials or techniques that will provide electrical continuity over the surface of the spacecraft. The materials' photoemission, secondary emission, thermooptical, physical, and electrical properties in the space vacuum environment both in the presence and absence of electrical stress and ultraviolet, electron, and particulate radiation, are important to the achievement of charge control. The materials must be stable or have predictable response to exposure to the space environment for long periods of time. The materials of interest include conductive polymers, paints, transparent films and coatings as well as fabric coating interweaves.

  7. Increasing Underrepresented Scientists in Cancer Research: The UCSD CURE Program

    OpenAIRE

    Alfred, Lawrence; Beerman, Paula R.; Tahir, Zunera; LaHousse, Sheila F.; Russell, Percy; Sadler, Georgia Robins

    2010-01-01

    The Moores UCSD Cancer Center’s Continuing Umbrella of Research Experiences program aims to increase the number of underrepresented students pursuing careers in cancer research, cancer care, and health disparities research. Participants receive 8 weeks of laboratory and classroom training during the summer followed by participation in research mentors’ laboratories. Of the 82 CURE students accrued (2002 and 2008), 91% persisted in science after 1 year. Of the 63 students eligible to graduate ...

  8. Developing program theory for purveyor programs

    OpenAIRE

    Oosthuizen, Christa; Louw, Johann

    2013-01-01

    Background Frequently, social interventions produce less for the intended beneficiaries than was initially planned. One possible reason is that ideas embodied in interventions are not self-executing and require careful and systematic translation to put into practice. The capacity of implementers to deliver interventions is thus paramount. Purveyor organizations provide external support to implementers to develop that capacity and to encourage high-fidelity implementation behavior. Literature ...

  9. Alternative Splicing Programs in Prostate Cancer

    OpenAIRE

    Claudio Sette

    2013-01-01

    Prostate cancer (PCa) remains one of the most frequent causes of death for cancer in the male population. Although the initial antiandrogenic therapies are efficacious, PCa often evolves into a hormone-resistant, incurable disease. The genetic and phenotypic heterogeneity of this type of cancer renders its diagnosis and cure particularly challenging. Mounting evidence indicates that alternative splicing, the process that allows production of multiple mRNA variants from each gene, contributes ...

  10. NCI Community Oncology Research Program (NCORP) | Division of Cancer Prevention

    Science.gov (United States)

    The NCI Community Oncology Research Program (NCORP) is a national network of cancer care investigators, providers, academia, and other organizations that care for diverse populations in health systems. View the list of publications from NCORP. | Clinical Trials network of cancer care professionals who care for diverse populations across the U.S.

  11. DCP Leading NIH Glycoscience Common Fund Program; Funding Opportunities Open | Division of Cancer Prevention

    Science.gov (United States)

    NCI's Division of Cancer Prevention is a leading participant for a key initiative in the National Institutes of Health (NIH) Glycoscience Common Fund program. This program supports development of accessible and affordable new tools and technologies for studying the role complex carbohydrates in health and disease. |

  12. Major Programs | Division of Cancer Prevention

    Science.gov (United States)

    The Division of Cancer Prevention supports major scientific collaborations, research networks, investigator-initiated grants, postdoctoral training, and specialized resources across the United States. |

  13. New director of Outreach Program Development named

    OpenAIRE

    Felker, Susan B.

    2005-01-01

    Jeri L. Childers recently joined Virginia Tech as director of Outreach Program Development. Childers comes to the university from Pennsylvania State University, where she was director of Workforce Education and Development Programs

  14. HOX Genes in Pancreatic Development and Cancer

    OpenAIRE

    Sophie Gray; Hardev S Pandha; Agnieszka Michael; Richard Morgan; Gary Middleton

    2011-01-01

    The HOX genes are a family of homeodomain-containing transcription factors that determine cellular identity during development and which are subsequently re-expressed in many types of cancer. Some recent studies have shown that HOX genes may have key roles both in pancreatic development and in adult diseases of the pancreas, including cancer. In this review we consider recent advances in elucidating the role of HOX genes in these processes, how they may connect early developmental events to s...

  15. Simulation of reduced breast cancer mortality in breast cancer screening programs

    International Nuclear Information System (INIS)

    The breast cancer screening programs are an essential tool in the fight against breast cancer. Currently, many questions concerning the setup of these programs are open, namely: age range of women who undergo the same, frequency of mammography, ... The effectiveness of a program should be evaluated in terms of mortality reduction is its systematic implementation in the population. In this sense, we performed Monte Carlo simulations to assess that these reductions.

  16. Assessment of environmental and genetic factors in the etiology of childhood cancers: the Childrens Cancer Group epidemiology program.

    Science.gov (United States)

    Robison, L L; Buckley, J D; Bunin, G

    1995-01-01

    The occurrence of cancer during childhood represents one of the leading causes of death within the pediatric and adolescent age group. It is estimated that approximately 8000 children will be diagnosed annually with cancer in the United States. Epidemiologic research addressing the etiology of childhood cancer has been limited because of the difficulties in identifying a sufficiently large study population. Moreover, the use of retrospectively ascertained childhood cancer cases in epidemiologic investigations has restricted the incorporation of biological and clinical parameters. The Childrens Cancer Group has developed an active program in epidemiologic research, with over a decade of experience demonstrating the feasibility and strengths of conducting analytic epidemiologic studies within a cooperative clinical trials network. The availability of detailed clinical and biologic data on cases diagnosed within the cooperative group facilitates the transfer of state-of-the-art technology to epidemiologic research. PMID:8549456

  17. Cost of Starting Colorectal Cancer Screening Programs: Results From Five Federally Funded Demonstration Programs

    OpenAIRE

    Janet Royalty, MS; James Gardner, MSPH; A. Blythe Ryerson, MPH; Marion Nadel, PhD; Florence K. L. Tangka, PhD; Sujha Subramanian, PhD; Bela Bapat, MS; Laura C. Seeff, MD; Amy DeGroff, MPH

    2008-01-01

    Introduction In 2005, the Centers for Disease Control and Prevention (CDC) started a 3-year colorectal cancer screening demonstration project and funded five programs to explore the feasibility of a colorectal cancer program for the underserved U.S. population. CDC is evaluating the five programs to estimate implementation cost, identify best practices, and determine the most cost-effective approach. The objectives are to calculate start-up costs and estimate funding requirements for widespre...

  18. The Prevention of Liver Cancer by HBV Vaccine Program

    Institute of Scientific and Technical Information of China (English)

    TAO Xiong

    2002-01-01

    Objective To recognize the HBV vaccine program for prevention of the hepatic cancer.Methods To discuss the relation between the HBV and hepatic cancer arising, and to discuss the immunology respond of the HBV vaccine (HBV surface antigen protein) in our patient group. Result Our data indicates that the predisposing of the HBV infection is required for the hepatic cancer arising and for the high expression of the AFP gene, and our data indicates that the HBV vaccine can induce highly immuno respond in about 78.8 % of the adult for achieving the HBV prevention status and the hepatic cancer prevention status.

  19. Reimagining care for adolescent and young adult cancer programs: Moving with the times.

    Science.gov (United States)

    Gupta, Abha A; Papadakos, Janet K; Jones, Jennifer M; Amin, Leila; Chang, Eugene K; Korenblum, Chana; Mina, Daniel Santa; McCabe, Lianne; Mitchell, Laura; Giuliani, Meredith E

    2016-04-01

    Literature regarding the development of adolescent and young adult (AYA) cancer programs has been dominantly informed by pediatric centers and practitioners. However, the majority of young adults are seen and treated at adult cancer centers, in which cancer volumes afford the development of innovative supportive care services. Although the supportive care services in adult cancer centers are helpful to AYAs, some of the most prominent and distinct issues faced by AYAs are not adequately addressed through these services alone. This article describes how the AYA Program at Princess Margaret Cancer Centre has collaborated with existing supportive care services in addition to supplying its own unique services to meet the comprehensive needs of AYAs in the domains of: symptom management (sexuality and fatigue), behavior modification (return to work and exercise), and health services (advanced cancer and survivorship). These collaborations are augmented by patient education interventions and timely referrals. The objective of this article was to assist other centers in expanding existing services to address the needs of AYA patients with cancer. Cancer 2016;122:1038-1046. © 2016 American Cancer Society. PMID:26848554

  20. CANCER NANOTECHNOLOGY: RECENT TRENDS AND DEVELOPMENTS

    Directory of Open Access Journals (Sweden)

    Mr. Hardik R Mody, B.Pharm

    2011-01-01

    Full Text Available Cancer is one of the leading causes of death worldwide. Deaths from cancer are continuously rising worldwide with a projection of about 12 million deaths from cancer in 2030. Hence, over the past few years, tremendous attention has been given to the cancer related research and there has been an outstanding progress in the basic cancer biology. The present article deals with the recent developments in cancer nanotechnologies and its potential application in cancer therapeutics. Nanotechnology is one of the most rapidly growing fields in the 21st century. It may be defined as the creation of materials, drugs and devices that are used to manipulate matter of size in the range of 1-100nm. Nanotechnology has found its applications in many fields related to medicine including novel drug delivery systems, biotechnology to name a few. Many different types of nanosystems have been utilized in diagnostics and therapeutics of various diseases. To subside the disadvantages of conventional cancer therapeutics, nanotechnology has been given considerable attention. In this paper, the current nanotechnologies that can be utilized in oncological interventions will be discussed. These mainly include arrays of nanocantilevers, nanotubes and nanowires for multiplexing detection, multifunctional injectable nanovectors for therapeutics and diagnostics.

  1. US advanced LMFBR fuels development program

    International Nuclear Information System (INIS)

    Following the oil crisis in 1974, a national Advanced LMFBR Fuels Development Program was initiated in the U. S. This program was developed on the basis of the experience obtained during the exploratory years. As a result, most aspects of advanced fuels development have been expanded in the U. S. in a unified national program. The experience obtained during the exploratory phase has been summarized previously. The purpose of this paper is to describe the new program and to summarize recent major findings

  2. Pancreatic Cancer and Cancer Screening Programs: From Nihilism to Hope

    Directory of Open Access Journals (Sweden)

    Raffaele Pezzilli

    2010-11-01

    Full Text Available The most common incipit of papers published regarding exocrine pancreatic neoplasms is that pancreatic cancer is one of the most lethal cancers, with a rate of incidence equal to that of mortality. Pancreatic cancer is a heterogeneous group of neoplasms in which pancreatic ductal adenocarcinoma is the most common. For the most part, the problems related to the early diagnosis of pancreatic adenocarcinoma are three: 1 to better understand the biology of this tumor; 2 to better investigate the precursors of this tumor; and 3 to plan projects for pancreatic cancer screening in high-risk individuals. Recently, Yachida et al. [1] performed rapid autopsies on seven individuals with Stage IV pancreatic cancer and they found that the clonal populations which give rise to distant metastases are represented within the primary carcinoma, but these clones are genetically evolved from the original parental, non-metastatic clone. Thus, the genetic heterogeneity of the metastases reflects that of the primary carcinoma. Most important, when the authors performed a quantitative analysis of the timing of the genetic evolution of pancreatic cancer, they found that there was at least a decade between the occurrence of the initial mutation and the birth of the parental, non-metastatic founder cell. At least five more years are required for the acquisition of metastatic ability and patients die an average two years thereafter. As underscored by the authors, these data have an important implication in planning population screening for the purpose of preventing pancreatic cancer deaths: in fact, quantitative analysis indicated a large window, of at least a decade, in which the disease could be diagnosed while it is still in the curative stage. This model also predicts an average of 6.8 years between the birth of the cell giving rise to the parental clone and the seeding of the index metastasis.

  3. Colorectal cancer development and advances in screening

    OpenAIRE

    Simon K

    2016-01-01

    Karen Simon Ventura County Gastroenterology Medical Group, Inc., Camarillo, CA, USA Abstract: Most colon tumors develop via a multistep process involving a series of histological, morphological, and genetic changes that accumulate over time. This has allowed for screening and detection of early-stage precancerous polyps before they become cancerous in individuals at average risk for colorectal cancer (CRC), which may lead to substantial decreases in the incidence of CRC. Despite the known b...

  4. Radiologic aspects of breast cancers detected through a breast cancer screening program

    International Nuclear Information System (INIS)

    Early detection in breast cancer and reduced mortality in women with this disease is today attributed to widespread use of mammography. High-quality performance is essential in all steps of breast cancer screening programs in order to avoid unnecessary anxiety and surgery in the women concerned. This report presents radiologic aspects of screening cancers. A total of 8370 asymptomatic women aged 50-69 years were screened with 2-view mammography, of which only 70 (0.84 percent) were selected for surgery after a thorough work-up. Cancers were verified histologically in 61 women and 9 showed non-malignant histology, giving a cancer detection rate of 7.3 cancers per thousand screened asymptomatic women. The benign/malignant ratio in the operated cases is thus approximately 1:7. The cancers detected showed all existing types of mammographic features where 77 percent (47 cases) showed rather typical findings, such as spiculated densities both with and without microcalcifications. The results indicate that surgery can be minimized without impairing the breast cancer detection rate. Radiologists in screening programs should be aware that a large proportion of non-palpable breast cancers present in rather unconventional forms. This point is important in order to maintain a high cancer detection rate and thereby justify the widespread use of mammography as a screening tool for breast cancer in asymptomatic women. (author). 20 refs.; 1 tab

  5. Quality control in screening programs for cervical cancer

    International Nuclear Information System (INIS)

    The malignancy of the cervix is one of the few locations avoidable cancers, if detected before it progresses to the infiltration. The most efficient way of early detection is through a screening program to provide women undertaking a regular and quality Pap smear. If this test results abnormal, the program offers easier access to specialized care, effective treatment, and follow-up. The objective of this article is to present usefulness of methods for quality control used in screening programs for cervical cancer to detect their inadequacies. Here are some factors and conditions that must be considered in each of the steps to take, for a cervical cancer screening program to be successful and to meet the objectives proposed in reducing mortality due to this cause. This document contains some useful indexes calculated to ensure quality throughout the process. There should be the measurement of quality throughout the screening process that allows collecting of reliable data as well as correcting deficiencies

  6. Programming Language and Artificial Intelligence Development.

    OpenAIRE

    Mrs. Rekha Purohit; Prof. Prabhat Mathur

    2013-01-01

    The term language means communication tool which is used to write Computer program and develop application, scripts, or other set of instructions for a computer to execute. Computer programming languages are used to write programs that define the behavior of a computer system. They are based on certain syntactic and semantic rules, which define the meaning of each of the programming language constructs. The syntactic and the semantic rules of every programming language define the language imp...

  7. Computer Program Development for House Cost Calculation

    OpenAIRE

    Korablev, Maxim

    2010-01-01

    The main purpose of this project was to develop a program, which can calculate the cost of houses. This program should accelerate a matching process between a company and users. Also the program should contain a database of building materials. The program language is PHP. PHP is a modern computer language for the development of web programs. The writing of a program code was based on the official PHP manual and a little support from a programmer in the company. For making the database of...

  8. Cancer Prevention Fellowship Program Application Period is Open until August 25 | Division of Cancer Prevention

    Science.gov (United States)

    The application period for the NCI Cancer Prevention Fellowship Program (CPFP) is open. Since 1987, CPFP has provided funding support for post-doctoral Fellows to train the next generation of researchers and leaders in the field. |

  9. [Colorectal cancer screening programs in the population at average risk in the European Union and Spain].

    Science.gov (United States)

    Grau, Jaume; Serradesanferm, Anna; Polbach, Sandra; García-Basteiro, Alberto L; Trilla, Antoni; Castells, Antoni

    2010-02-01

    There is broad international consensus on the need for colorectal cancer screening in men and women aged 50 years old or older with no personal or familial history of adenoma or colorectal cancer. The main problem is the disagreement among the various screening guidelines on the best screening method. The European Union (2003) extended the recommendation of implanting colorectal cancer screening using the fecal occult blood test (FOBT) in the population aged between 50 and 74 years. Seventy percent of the member states are introducing a program but there is wide heterogeneity. In Spain, 2-yearly FOBT is recommended in the target population aged 50 to 69 years. Currently, three autonomous communities have developed pilot programs and are extending the program to the entire population. Many other communities have announced they will commence programs shortly. PMID:19523716

  10. HOX Genes in Pancreatic Development and Cancer

    Directory of Open Access Journals (Sweden)

    Sophie Gray

    2011-05-01

    Full Text Available The HOX genes are a family of homeodomain-containing transcription factors that determine cellular identity during development and which are subsequently re-expressed in many types of cancer. Some recent studies have shown that HOX genes may have key roles both in pancreatic development and in adult diseases of the pancreas, including cancer. In this review we consider recent advances in elucidating the role of HOX genes in these processes, how they may connect early developmental events to subsequent adult disease, and their potential both as diagnostic markers and therapeutic targets.

  11. Necroptosis: an alternative cell death program defending against cancer.

    Science.gov (United States)

    Chen, Dongshi; Yu, Jian; Zhang, Lin

    2016-04-01

    One of the hallmarks of cancer is resistance to programmed cell death, which maintains the survival of cells en route to oncogenic transformation and underlies therapeutic resistance. Recent studies demonstrate that programmed cell death is not confined to caspase-dependent apoptosis, but includes necroptosis, a form of necrotic death governed by Receptor-Interacting Protein 1 (RIP1), RIP3, and Mixed Lineage Kinase Domain-Like (MLKL) protein. Necroptosis serves as a critical cell-killing mechanism in response to severe stress and blocked apoptosis, and can be induced by inflammatory cytokines or chemotherapeutic drugs. Genetic or epigenetic alterations of necroptosis regulators such as RIP3 and cylindromatosis (CYLD), are frequently found in human tumors. Unlike apoptosis, necroptosis elicits a more robust immune response that may function as a defensive mechanism by eliminating tumor-causing mutations and viruses. Furthermore, several classes of anticancer agents currently under clinical development, such as SMAC and BH3 mimetics, can promote necroptosis in addition to apoptosis. A more complete understanding of the interplay among necroptosis, apoptosis, and other cell death modalities is critical for developing new therapeutic strategies to enhance killing of tumor cells. PMID:26968619

  12. Staff-Development Program. Maxi I Practicum.

    Science.gov (United States)

    Tutalo, Anthony J.

    Described are various aspects of a program to train school personnel to meet the special needs of mainstreamed children. The staff development program is discussed in terms of program responsibility, strategy, and steps taken by the principal in the implementation procedure. The four stages of Project RETAP, a special education in-service program…

  13. 76 FR 13404 - Cancer Therapy Evaluation Program Intellectual Property Option to Collaborator

    Science.gov (United States)

    2011-03-11

    ... Cancer Treatment and Diagnosis, is announcing the final revision of the NCI Cancer Therapy Evaluation... Register of April 6, 2010 (FR Vol. 65, No. 65), the National Cancer Institute, Division of Cancer Treatment..., Associate Director, Cancer Therapy Evaluation Program, Division of Cancer Treatment and......

  14. Innovative Technology Development Program. Final summary report

    International Nuclear Information System (INIS)

    Through the Office of Technology Development (OTD), the U.S. Department of Energy (DOE) has initiated a national applied research, development, demonstration, testing, and evaluation program, whose goal has been to resolve the major technical issues and rapidly advance technologies for environmental restoration and waste management. The Innovative Technology Development (ITD) Program was established as a part of the DOE, Research, Development, Demonstration, Testing, and Evaluation (RDDT ampersand E) Program. The plan is part of the DOE's program to restore sites impacted by weapons production and to upgrade future waste management operations. On July 10, 1990, DOE issued a Program Research and Development Announcement (PRDA) through the Idaho Operations Office to solicit private sector help in developing innovative technologies to support DOE's clean-up goals. This report presents summaries of each of the seven projects, which developed and tested the technologies proposed by the seven private contractors selected through the PRDA process

  15. Program Development through Formative Evaluation: The SWRL Instructional Concepts Program.

    Science.gov (United States)

    Scott, Roger O.

    The SWRL Instructional Concepts Program has been developed to help kindergarten children quickly learn conceptual skills which are fundamental to academic achievement. Formative evaluation procedures employed in the 1968-69 tryout were primarily responsible for the changes incorporated into the present program. These procedures included teacher…

  16. Innovative fertility preservation strategies and programs for young adults with cancer

    Directory of Open Access Journals (Sweden)

    Johnson RH

    2016-01-01

    Full Text Available Rebecca H Johnson Division of Pediatric Hematology/Oncology, Department of Pediatrics, Mary Bridge Hospital, MultiCare Health System, Tacoma, WA, USA Abstract: Preservation of fertility is a key issue for young adults newly diagnosed with cancer. Up to 90% of cancer patients under the age of 45 are at risk for fertility impairment following cancer therapy. Cancer patients who are not offered fertility preservation (FP and those who become infertile following therapy may experience long-term psychosocial distress. This review summarizes the numerous effective strategies for preserving fertility, including sperm banking, electroejaculation, and testicular sperm extraction in males and cryopreservation of embryos or oocytes in females. This paper also highlights novel methods currently in development, such as gonadal tissue cryopreservation and in vitro maturation of gametes. In women, anti-Mullerian hormone is emerging as an accurate marker of ovarian reserve, and the use of gonadotropin releasing hormone analogs to protect fertility is increasingly well validated. Although national guidelines mandate FP counseling and referral prior to the start of cancer therapy for patients with reproductive potential, only a minority of young cancer patients in the USA currently take steps to preserve fertility prior to the start of therapy. Some cancer centers across the USA are developing institutional strategies to support FP, resulting in increased utilization of fertility services by newly diagnosed cancer patients. Keywords: young adult, cancer, fertility preservation, program, oocyte, sperm

  17. Automotive Stirling Engine Development Program

    Science.gov (United States)

    Nightingale, N.; Ernst, W.; Richey, A.; Simetkosky, M.; Smith, G.; Antonelli, M. (Editor)

    1983-01-01

    Mod I engine testing and test results, the test of a Mod I engine in the United States, Mod I engine characterization and analysis, Mod I Transient Test Bed fuel economy, Mod I-A engine performance are discussed. Stirling engine reference engine manufacturing and reduced size studies, components and subsystems, and the study and test of low-cost casting alloys are also covered. The overall program philosophy is outlined, and data and results are presented.

  18. Maypole (Hoop/Column) concept development program

    Science.gov (United States)

    Sullivan, M. R.

    1982-01-01

    The program is divided into six tasks: preliminary design and performance; materials development; advanced concepts; economic assessment; demonstration/verification models; and a 15 meter engineering model. All support the main objective of the program which is the technology development necessary to evaluate, design, manufacture, package, transport and deploy the Hoop/Column reflector by means of a ground-based test program. Progress for each task is reported.

  19. Coastal nonpoint pollution control program: Program development and approval guidance

    International Nuclear Information System (INIS)

    The document, developed by NOAA and EPA, contains guidance for states in developing and implementing their coastal nonpoint pollutant source programs. It describes the requirements that must be met, including: the geographic scope of the program; the pollutant sources to be addressed; the types of management measures used; the establishment of critical areas; technical assistance, public participation, and administrative coordination; and, the process for program submission and Federal approval. The document also contains the criteria by which NOAA and EPA will review the states' submissions

  20. Population-based programs for increasing colorectal cancer screening in the United States.

    Science.gov (United States)

    Verma, Manisha; Sarfaty, Mona; Brooks, Durado; Wender, Richard C

    2015-01-01

    Answer questions and earn CME/CNE Screening to detect polyps or cancer at an early stage has been shown to produce better outcomes in colorectal cancer (CRC). Programs with a population-based approach can reach a large majority of the eligible population and can offer cost-effective interventions with the potential benefit of maximizing early cancer detection and prevention using a complete follow-up plan. The purpose of this review was to summarize the key features of population-based programs to increase CRC screening in the United States. A search was conducted in the SCOPUS, OvidSP, and PubMed databases. The authors selected published reports of population-based programs that met at least 5 of the 6 International Agency for Research on Cancer (IARC) criteria for cancer prevention and were known to the National Colorectal Cancer Roundtable. Interventions at the level of individual practices were not included in this review. IARC cancer prevention criteria served as a framework to assess the effective processes and elements of a population-based program. Eight programs were included in this review. Half of the programs met all IARC criteria, and all programs led to improvements in screening rates. The rate of colonoscopy after a positive stool test was heterogeneous among programs. Different population-based strategies were used to promote these screening programs, including system-based, provider-based, patient-based, and media-based strategies. Treatment of identified cancer cases was not included explicitly in 4 programs but was offered through routine medical care. Evidence-based methods for promoting CRC screening at a population level can guide the development of future approaches in health care prevention. The key elements of a successful population-based approach include adherence to the 6 IARC criteria and 4 additional elements (an identified external funding source, a structured policy for positive fecal occult blood test results and confirmed cancer

  1. Automotive Stirling engine development program: A success

    Science.gov (United States)

    Tabata, W. K.

    1987-01-01

    The original 5-yr Automotive Stirling Engine Development Program has been extended to 10 years due to reduced annual funding levels. With an estimated completion date of April 1988, the technical achievements and the prospectives of meeting the original program objectives are reviewed. Various other applications of this developed Stirling engine technology are also discussed.

  2. Developing effective consultation programs for regulatory development

    Energy Technology Data Exchange (ETDEWEB)

    Paulson, K.F. [National Energy Board, Ottawa, ON (Canada)

    2003-07-01

    Canada's National Energy Board promotes safety, environmental protection and economic efficiency in the regulation of pipelines, energy development and trade. The Board regulates the design, construction, operation and abandonment of interprovincial and international pipelines within Canada. It also holds regulatory control over tolls and tariffs of interprovincial and international pipelines as well as the export, exploration and development of natural gas and oil resources. Regulatory authorities are required to consult with stakeholders whenever new regulations or amendments to existing regulations are proposed. The Board has launched new initiatives for compliance with Damage Prevention Regulations. Stakeholders were advised through consultative processes such as plain language drafts, open houses, focus meetings and newsletters. The proposed Damage Prevention Regulation will govern activities that have the potential to damage a pipeline. The regulations will apply to pipeline operators, excavators, landowners, municipal planners, emergency responders, and utility companies dealing with federally regulated pipelines. 7 refs., 1 tab.

  3. Community Education: Developing a Program.

    Science.gov (United States)

    Crocombe, N. G.

    1980-01-01

    Community education is concerned with the development of the individual and the development of the community to improve the quality of life. Community colleges act as catalysts by coordinating citizen and agency participation and community resources to improve educational opportunities for all. (SK)

  4. Phase 0/I/II Cancer Prevention Clinical Trials Program (Consortia) | Division of Cancer Prevention

    Science.gov (United States)

    Five cancer research centers lead multiple collaborative networks to assess potential cancer preventive agents and to conduct early clinical development of promising preventive agents. Also called the Consortia for Early Phase Prevention Trials, the studies require extensive biomarker analysis, investigation of the biologic effects of the cancer preventive agents on their intended molecular targets and on multiple endpoints associated with carcinogenesis, and correlation with clinically relevant endpoints.  | Systematic early clinical development of promising preventive agents through five major medical research centers.

  5. The role of neutering in cancer development.

    Science.gov (United States)

    Smith, Annette N

    2014-09-01

    Increased discussion on the influence of neutering on cancer development has been recently prompted with several studies that seem to indicate that incidence of some cancers may be increased with castration or spaying in our canine populations. Although the data are thought-provoking, we may not be able to extrapolate findings in single dog breeds to the entire species. Additionally, societal and humane issues related to pet overpopulation, as well as the incidence of other noncancerous diseases, behavior issues, and potentially decreased overall lifespan in unaltered animals must be taken into consideration before wholesale rejection of neutering in pets. PMID:25174910

  6. Program Development Tools and Infrastructures

    Energy Technology Data Exchange (ETDEWEB)

    Schulz, M

    2012-03-12

    Exascale class machines will exhibit a new level of complexity: they will feature an unprecedented number of cores and threads, will most likely be heterogeneous and deeply hierarchical, and offer a range of new hardware techniques (such as speculative threading, transactional memory, programmable prefetching, and programmable accelerators), which all have to be utilized for an application to realize the full potential of the machine. Additionally, users will be faced with less memory per core, fixed total power budgets, and sharply reduced MTBFs. At the same time, it is expected that the complexity of applications will rise sharply for exascale systems, both to implement new science possible at exascale and to exploit the new hardware features necessary to achieve exascale performance. This is particularly true for many of the NNSA codes, which are large and often highly complex integrated simulation codes that push the limits of everything in the system including language features. To overcome these limitations and to enable users to reach exascale performance, users will expect a new generation of tools that address the bottlenecks of exascale machines, that work seamlessly with the (set of) programming models on the target machines, that scale with the machine, that provide automatic analysis capabilities, and that are flexible and modular enough to overcome the complexities and changing demands of the exascale architectures. Further, any tool must be robust enough to handle the complexity of large integrated codes while keeping the user's learning curve low. With the ASC program, in particular the CSSE (Computational Systems and Software Engineering) and CCE (Common Compute Environment) projects, we are working towards a new generation of tools that fulfill these requirements and that provide our users as well as the larger HPC community with the necessary tools, techniques, and methodologies required to make exascale performance a reality.

  7. Program Development Tools and Infrastructures

    International Nuclear Information System (INIS)

    Exascale class machines will exhibit a new level of complexity: they will feature an unprecedented number of cores and threads, will most likely be heterogeneous and deeply hierarchical, and offer a range of new hardware techniques (such as speculative threading, transactional memory, programmable prefetching, and programmable accelerators), which all have to be utilized for an application to realize the full potential of the machine. Additionally, users will be faced with less memory per core, fixed total power budgets, and sharply reduced MTBFs. At the same time, it is expected that the complexity of applications will rise sharply for exascale systems, both to implement new science possible at exascale and to exploit the new hardware features necessary to achieve exascale performance. This is particularly true for many of the NNSA codes, which are large and often highly complex integrated simulation codes that push the limits of everything in the system including language features. To overcome these limitations and to enable users to reach exascale performance, users will expect a new generation of tools that address the bottlenecks of exascale machines, that work seamlessly with the (set of) programming models on the target machines, that scale with the machine, that provide automatic analysis capabilities, and that are flexible and modular enough to overcome the complexities and changing demands of the exascale architectures. Further, any tool must be robust enough to handle the complexity of large integrated codes while keeping the user's learning curve low. With the ASC program, in particular the CSSE (Computational Systems and Software Engineering) and CCE (Common Compute Environment) projects, we are working towards a new generation of tools that fulfill these requirements and that provide our users as well as the larger HPC community with the necessary tools, techniques, and methodologies required to make exascale performance a reality.

  8. Development of cancer cooperative groups in Japan.

    Science.gov (United States)

    Fukuda, Haruhiko

    2010-09-01

    Investigator-initiated clinical trials are essential for improving the standard of care for cancer patients, because pharmaceutical companies do not conduct trials that evaluate combination chemotherapy using drugs from different companies, surgery, radiotherapy or multimodal treatments. Government-sponsored cooperative groups have played a vital role in developing cancer therapeutics since the 1950s in the USA; however, the establishment of these groups in Japan did not take place until 30 years later. Methodological standards for multicenter cancer clinical trials were established in the 1980s by the National Cancer Institute and cooperative groups. The Japan Clinical Oncology Group, one of the largest cooperative groups in the country, was instituted in 1990. Its data center and operations office, formed during the 1990s, applied the standard methods of US cooperative groups. At present, the Japan Clinical Oncology Group consists of 14 subgroups, a Data Center, an Operations Office, nine standing committees and an Executive Committee represented by the Japan Clinical Oncology Group Chair. Quality control and quality assurance at the Japan Clinical Oncology Group, including regular central monitoring, statistical methods, interim analyses, adverse event reporting and site visit audit, have complied with international standards. Other cooperative groups have also been established in Japan since the 1980s; however, nobody figures out all of them. A project involving the restructuring of US cooperative groups has been ongoing since 2005. Learning from the success of this project will permit further progress of the cancer clinical trials enterprise in Japan. PMID:20670961

  9. Cancer Drug Development: New Targets for Cancer Treatment.

    Science.gov (United States)

    Curt

    1996-01-01

    There is often a considerable lapse of time between the definition of what causes a disease in the laboratory and the development of successful therapy. However, the history of medicine teaches us that the need to understand the scientific basis of disease before the discovery of new treatments is both essential and inevitable. During the middle of the 19th century, the work of the great German pathologist, Rudolf Virchow, defined disease as having an anatomic or histologic basis. In the clinic, this scientific perspective would lead to increasingly effective and, often, increasingly aggressive surgical approaches to disease. Later in the 19th century, Koch's discovery of the tubercle bacillus (a discovery Virchow disbelieved and publication of which he thwarted, since he hypothesized that cancer, not microbes, caused consumption!), would define a microbiological basis for disease. With bacteria defined as a major cause of human suffering, the stage was set for the development of the discovery of effective antibiotics. In the early 20th century, the pioneering work of Banting, Best and others would show that disease can also have an endocrine or metabolic basis. This new body of scientific knowledge would lead not only to the specific discovery of insulin as an effective treatment for diabetes but also to a more general understanding of the role of hormones, vitamins and co-factors in human health and disease. Basic medical research and its successful translation into effective treatments has fundamentally altered the cause of human death. In the developed world, where access to the benefit of this work is available, infectious disease is not the problem it was in the days of Pasteur, Metchnikoff and Ehrlich. As we approach the millennium, science is now teaching us that diseases, particularly cancer, can have a molecular or genetic basis. Can successful application of this new knowledge be far behind? We are already seeing the application of this new knowledge in

  10. DNA damage checkpoint recovery and cancer development

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Haiyong [First affiliated hospital, Zhejiang University, School of medicine, Cancer Center, 79 Qingchun Road, Hangzhou 310003 (China); Zhang, Xiaoshan [Department of Genetics, University of Texas M.D. Anderson Cancer Center, Department of Genetics Unit 1010, 1515 Holcombe Blvd. Houston, TX 77030 (United States); Teng, Lisong, E-mail: lsteng@zju.edu.cn [First affiliated hospital, Zhejiang University, School of medicine, Cancer Center, 79 Qingchun Road, Hangzhou 310003 (China); Legerski, Randy J., E-mail: rlegersk@mdanderson.org [Department of Genetics, University of Texas M.D. Anderson Cancer Center, Department of Genetics Unit 1010, 1515 Holcombe Blvd. Houston, TX 77030 (United States)

    2015-06-10

    Cell cycle checkpoints were initially presumed to function as a regulator of cell cycle machinery in response to different genotoxic stresses, and later found to play an important role in the process of tumorigenesis by acting as a guard against DNA over-replication. As a counterpart of checkpoint activation, the checkpoint recovery machinery is working in opposition, aiming to reverse the checkpoint activation and resume the normal cell cycle. The DNA damage response (DDR) and oncogene induced senescence (OIS) are frequently found in precancerous lesions, and believed to constitute a barrier to tumorigenesis, however, the DDR and OIS have been observed to be diminished in advanced cancers of most tissue origins. These findings suggest that when progressing from pre-neoplastic lesions to cancer, DNA damage checkpoint barriers are overridden. How the DDR checkpoint is bypassed in this process remains largely unknown. Activated cytokine and growth factor-signaling pathways were very recently shown to suppress the DDR and to promote uncontrolled cell proliferation in the context of oncovirus infection. In recent decades, data from cell line and tumor models showed that a group of checkpoint recovery proteins function in promoting tumor progression; data from patient samples also showed overexpression of checkpoint recovery proteins in human cancer tissues and a correlation with patients' poor prognosis. In this review, the known cell cycle checkpoint recovery proteins and their roles in DNA damage checkpoint recovery are reviewed, as well as their implications in cancer development. This review also provides insight into the mechanism by which the DDR suppresses oncogene-driven tumorigenesis and tumor progression. - Highlights: • DNA damage checkpoint works as a barrier to cancer initiation. • DDR machinary response to genotoxic and oncogenic stress in similar way. • Checkpoint recovery pathways provide active signaling in cell cycle control. • Checkpoint

  11. DNA damage checkpoint recovery and cancer development

    International Nuclear Information System (INIS)

    Cell cycle checkpoints were initially presumed to function as a regulator of cell cycle machinery in response to different genotoxic stresses, and later found to play an important role in the process of tumorigenesis by acting as a guard against DNA over-replication. As a counterpart of checkpoint activation, the checkpoint recovery machinery is working in opposition, aiming to reverse the checkpoint activation and resume the normal cell cycle. The DNA damage response (DDR) and oncogene induced senescence (OIS) are frequently found in precancerous lesions, and believed to constitute a barrier to tumorigenesis, however, the DDR and OIS have been observed to be diminished in advanced cancers of most tissue origins. These findings suggest that when progressing from pre-neoplastic lesions to cancer, DNA damage checkpoint barriers are overridden. How the DDR checkpoint is bypassed in this process remains largely unknown. Activated cytokine and growth factor-signaling pathways were very recently shown to suppress the DDR and to promote uncontrolled cell proliferation in the context of oncovirus infection. In recent decades, data from cell line and tumor models showed that a group of checkpoint recovery proteins function in promoting tumor progression; data from patient samples also showed overexpression of checkpoint recovery proteins in human cancer tissues and a correlation with patients' poor prognosis. In this review, the known cell cycle checkpoint recovery proteins and their roles in DNA damage checkpoint recovery are reviewed, as well as their implications in cancer development. This review also provides insight into the mechanism by which the DDR suppresses oncogene-driven tumorigenesis and tumor progression. - Highlights: • DNA damage checkpoint works as a barrier to cancer initiation. • DDR machinary response to genotoxic and oncogenic stress in similar way. • Checkpoint recovery pathways provide active signaling in cell cycle control. • Checkpoint

  12. [Cigarette smoking among women attending cervical cancer screening program].

    Science.gov (United States)

    Walentowicz-Sadłecka, Małgorzata; Sadłecki, Paweł; Marszałek, Andrzej; Grabiec, Marek

    2012-01-01

    Cervical cancer is recognized as tobacco-related malignancy. HPV vaccination and introducing screening protocols were found as the best way to decrease cervical cancer related mortality. Besides the cytological screening programs of the uterine cervix smear, nowadays co-factors of carcinogenesis are taken into consideration, also. The aim of our study was to analyse data included in questionnaire of 310 women who underwent cytological examination wi thin cervical cancer screening program in our Department in 2011. There were no differences found between studied groups on rate of oral contraceptive or hormonal therapy use, as well as age and tobacco smoking. However, taking into account education and smoking, there was a significant correlation observed. Patients with higher education level smoked less often. The special attention should be paid to promote smoking cessation in the group of women who finished education on elementary level. PMID:23421059

  13. Reach Out for Health: A Church-Based Pilot Breast Cancer Education Program.

    Science.gov (United States)

    Allen, Jennifer Dacey; Peterson, Karen; Stoddard, Anne M.; Colditz, Graham; Sorensen, Gloria

    2002-01-01

    Describes the development and testing of Reach Out For Health, a peer-led, church-based breast cancer education program for African American and Hispanic communities. Pretest-posttest evaluation of screening practices and attitudes among women over age 40 indicated that the intervention was associated with improved attitudes toward mammography,…

  14. Comparing Relaxation Programs for Breast Cancer Patients Receiving Radiotherapy

    Science.gov (United States)

    In this study, women with breast cancer who have had surgery and are scheduled to undergo radiation therapy will be randomly assigned to one of two different stretching and relaxation programs or to a control group that will receive usual care.

  15. Development of operation individual dosimetry programs in a developing country

    International Nuclear Information System (INIS)

    Development of Operational Individual Dosimetry (OID) Programs is the principle rationale for any national radiation protection regulatory program in both developed and developing countries. Individual dosimetry for external radiation means making exposure measurements by equipment carried out on the persons or workers. An operational individual dosimetry (OID) program is defined as development of a program in an operational state to provide national or institutional dosimetry services; i.e. to cover routine, operational and special monitoring as defined by ICRP 35. The development of an OID program depends on many legal, administrative, psychological and technical factors such as number of institutions and radiation workers or persons to be monitored, radiation types and conditions of the workplaces, the state of related sciences and technologies, radiation protection infrastructure as regard to laws and regulations, the existence of qualified leader and manpower, desire to develop such a program, degree of self-dependency required, etc. Although development of such a program is fairly easy with a proper arrangement, some problems still exist in particular in a developing country. In this paper, the stated points and recommendations for development of OID programs in developing countries based on the experiences of the Islamic Republic of Iran and some other countries are presented and discussed. (author). 32 refs

  16. Power Burst Facility/Boron Neutron Capture Therapy Program for cancer treatment

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, A.L. (ed.); Dorn, R.V. III.

    1990-08-01

    This report discusses monthly progress in the Power Boron Facility/Boron Neutron Capture Therapy (PBF/BNCT) Program for Cancer Treatment. Highlights of the PBF/BNCT Program during August 1990 include progress within the areas of: Gross Boron Analysis in Tissue, Blood, and Urine, boron microscopic (subcellular) analytical development, noninvasive boron quantitative determination, analytical radiation transport and interaction modeling for BNCT, large animal model studies, neutron source and facility preparation, administration and common support and PBF operations.

  17. Design of clinical trials for therapeutic cancer vaccines development.

    Science.gov (United States)

    Mackiewicz, Jacek; Mackiewicz, Andrzej

    2009-12-25

    Advances in molecular and cellular biology as well as biotechnology led to definition of a group of drugs referred to as medicinal products of advanced technologies. It includes gene therapy products, somatic cell therapeutics and tissue engineering. Therapeutic cancer vaccines including whole cell tumor cells vaccines or gene modified whole cells belong to somatic therapeutics and/or gene therapy products category. The drug development is a multistep complex process. It comprises of two phases: preclinical and clinical. Guidelines on preclinical testing of cell based immunotherapy medicinal products have been defined by regulatory agencies and are available. However, clinical testing of therapeutic cancer vaccines is still under debate. It presents a serious problem since recently clinical efficacy of the number of cancer vaccines has been demonstrated that focused a lot of public attention. In general clinical testing in the current form is very expensive, time consuming and poorly designed what may lead to overlooking of products clinically beneficial for patients. Accordingly regulatory authorities and researches including Cancer Vaccine Clinical Trial Working Group proposed three regulatory solutions to facilitate clinical development of cancer vaccines: cost-recovery program, conditional marketing authorization, and a new development paradigm. Paradigm includes a model in which cancer vaccines are investigated in two types of clinical trials: proof-of-principle and efficacy. The proof-of-principle trial objectives are: safety; dose selection and schedule of vaccination; and demonstration of proof-of-principle. Efficacy trials are randomized clinical trials with objectives of demonstrating clinical benefit either directly or through a surrogate. The clinical end points are still under debate. PMID:19835869

  18. Automotive Stirling engine development program

    Science.gov (United States)

    Ernst, W.; Piller, S.; Richey, A.; Simetkosky, M.; Antonelli, M. (Editor)

    1982-01-01

    Activities performed on Mod I engine testing and test results, progress in manufacturing, assembling and testing of a Mod I engine in the United States, P40 Stirling engine dynamometer and multifuels testing, analog/digital controls system testing, Stirling reference engine manufacturing and reduced size studies, components and subsystems, and computer code development are summarized.

  19. BK polyomavirus association with colorectal cancer development.

    Science.gov (United States)

    Khabaz, M N; Nedjadi, T; Gari, M A; Al-Maghrabi, J A; Atta, H M; Basuni, A A; Elderwi, D A

    2016-01-01

    The development of human neoplasms can be provoked by exposure to one of several viruses. Burkitt lymphoma, cervical carcinoma, and hepatocellular carcinoma are associated with Epstein-Barr, human papilloma, and hepatitis B virus infections, respectively. Over the past three decades, many studies have attempted to establish an association between colorectal cancer and viruses, with debatable results. The aim of the present research was to assess the presence of BK polyomavirus (BKV) DNA and protein in colorectal cancer samples from patients in the Western Province of Saudi Arabia. DNA extracted from archival samples of colorectal cancer tissues was analyzed for BKV sequences using polymerase chain reaction (PCR)-based techniques. In addition, expression of a BKV protein was assessed using immunohistochemical staining. None of the tumor and control samples examined tested positive for BKV DNA in PCR assays. Furthermore, immunohistochemical staining failed to detect viral proteins in both cancer and control specimens. These results may indicate that BKV is not associated with the development of colorectal adenocarcinoma in patients in the Western Province of Saudi Arabia. PMID:27173319

  20. Ultrashort pulsed laser technology development program

    Science.gov (United States)

    Manke, Gerald C.

    2014-10-01

    The Department of Navy has been pursuing a technology development program for advanced, all-fiber, Ultra Short Pulsed Laser (USPL) systems via Small Business Innovative Research (SBIR) programs. Multiple topics have been published to promote and fund research that encompasses every critical component of a standard USPL system and enable the demonstration of mJ/pulse class systems with an all fiber architecture. This presentation will summarize published topics and funded programs.

  1. Developing and implementing a career ladder program.

    Science.gov (United States)

    Wall, Michelle

    2007-01-01

    A career ladder program is a formal management tool used not only by managers looking to recognize and retain employees, but also by employees seeking growth opportunities. A career ladder program involves careful development, frequent and effective communication during implementation, and activities focused on measuring program effectiveness. Career ladders are a way to increase productivity and staff versatility; improve morale, clinical quality, and staff satisfaction; reduce turnover; promote professional growth and job enrichment; and improve patient care. PMID:17696072

  2. The effectiveness of an abbreviated training program for health workers in breast cancer awareness: innovative strategies for resource constrained environments

    OpenAIRE

    Mutebi, Miriam; Wasike, Ronald; Mushtaq, Ahmed; Kahie, Aideed; Ntoburi, Stephen

    2013-01-01

    Background Breast cancer is characterized by late presentation and significant morbidity and mortality in developing countries. Breast screening aids in early detection of breast cancer. Nurses are uniquely placed to provide advocacy and screening in a resource limited environment. Objectives To assess the effectiveness of an abbreviated training program in breast cancer awareness on nurses at a tertiary hospital, in a resource constrained environment. Methods Using a statistical tool, the So...

  3. Developing an Environmental Ethic in Outdoor Programs.

    Science.gov (United States)

    McRae, Keith

    1986-01-01

    Argues that both short- and long-term outdoor education and wilderness programs should promote environmental awareness and the development of an environmental ethic. Outlines examples of approaches to integrating environmental goals and concepts into outdoor experiential education programs offered by Australian elementary and secondary schools and…

  4. Career Development in Language Education Programs

    Science.gov (United States)

    Shawer, Saad Fathy; Alkahtani, Saad Ali

    2013-01-01

    This study assesses the influence of a two-year language program evaluation on program directors and faculty career development. The study makes use of mixed-paradigms (positivism and qualitative interpretive), mixed-strategies (survey research and qualitative evaluation), one-way analysis of variance (ANOVA) and a post-hoc test of multiple…

  5. The US Liquid Metal Reactor Development Program

    International Nuclear Information System (INIS)

    The US Liquid Metal Reactor Development Program has been restructured to take advantage of the opportunity today to carry out R and D on truly advanced reactor technology. The program gives particular emphasis to improvements to reactor safety. The new directions are based on the technology of the Integral Fast Reactor (IFR). Much of the basis for superior safety performance using IFR technology has been experimentally verified and aggressive programs continue in EBR-II and TREAT. Progress has been made in demonstrating both the metallic fuel and the new electrochemical processes of the IFR. The FFTF facility is converting to metallic fuel; however, FFTF also maintains a considerable US program in oxide fuels. In addition, generic programs are continuing in steam generator testing, materials development, and, with international cooperation, aqueous reprocessing. Design studies are carried out in conjunction with the IFR technology development program. In summary, the US maintains an active development program in Liquid Metal Reactor technology, and new directions in reactor safety are central to the program

  6. Economic and Workforce Development Program Annual Report

    Science.gov (United States)

    California Community Colleges, Chancellor's Office, 2014

    2014-01-01

    California's community colleges continue to play a crucial role in the state's economy by providing students with the skills and knowledge to succeed and by advancing the economic growth and global competitiveness of California and its regional economies through the Economic and Workforce Development Program (EWD). The EWD program invests in the…

  7. Interactive Programming Support for Secure Software Development

    Science.gov (United States)

    Xie, Jing

    2012-01-01

    Software vulnerabilities originating from insecure code are one of the leading causes of security problems people face today. Unfortunately, many software developers have not been adequately trained in writing secure programs that are resistant from attacks violating program confidentiality, integrity, and availability, a style of programming…

  8. Be smart against cancer! A school-based program covering cancer-related risk behavior

    OpenAIRE

    Stölzel, Friederike; Seidel, Nadja; Uhmann, Stefan; Baumann, Michael; Berth, Hendrik; Hoyer, Jürgen; Ehninger, Gerhard

    2014-01-01

    Background: Several studies suggest that most school-age children are poorly informed about cancer risk factors. This study examines the effectiveness of the ‘Be smart against cancer’ (BSAC) program in promoting cancer awareness and intentions to engage in health-promoting behavior. Methods: 235 seventh-grade students were randomized to either the intervention (N = 152) or the wait-control group (N = 83). The intervention included the modules: “What is cancer?,” “Sun protection,” “Non smoking...

  9. Antiangiogenic gene therapy of cancer: recent developments

    OpenAIRE

    Libutti Steven K; Blazer Dan G; Tandle Anita

    2004-01-01

    Abstract With the role of angiogenesis in tumor growth and progression firmly established, considerable effort has been directed to antiangiogenic therapy as a new modality to treat human cancers. Antiangiogenic agents have recently received much widespread attention but strategies for their optimal use are still being developed. Gene therapy represents an attractive alternative to recombinant protein administration for several reasons. This review evaluates the potential advantages of gene t...

  10. Hydrogen engine development: Experimental program

    Energy Technology Data Exchange (ETDEWEB)

    Van Blarigan, P. [Sandia National Lab., Livermore, CA (United States)

    1996-10-01

    In the continuing development of a hydrogen fueled IC engine optimized for application to a generator set or hybrid vehicle, experiments were performed at Sandia National Laboratories on two engine configurations. The intent is to maximize thermal efficiency while complying with strict emissions standards. The initial investigation was conducted utilizing a spark ignited 0.491 liter single cylinder Onan engine and has progressed to a spark ignited 0.850 liter modified for single cylinder operation Perkins engine. Both combustion chamber geometries were {open_quotes}pancake{close_quotes} shaped and achieved a compression ratio of 14:1. The engines were operated under premixed conditions. The results demonstrate that both engines can comply with the California Air Resources Board`s proposed Equivalent Zero Emission Vehicle standards for NO{sub x} during operation at an equivalence ratio of 0.4. The Onan engine achieved an indicated thermal efficiency of 43% at 1800 RPM, as determined by integration of the pressure-volume relationships. Initial experiments with the larger displacement Perkins engine have realized a gain, relative to the Onan engine, in indicated thermal efficiency of 2% at 1800 RPM, and 15% at 1200 RPM.

  11. The Asian Grocery Store-Based Cancer Education Program: Creating New Education Modules.

    Science.gov (United States)

    Truong, Linh; Tat, John; Booy, Molly; Le, Annie; Marasigan, Jeanne Marie; Yuan, Christine; Zeng, Athena; Panchal, Anand; Sadler, Georgia Robins

    2016-06-01

    Operating since 1994, the UCSD Moores Cancer Center's Asian Grocery Store-Based Cancer Education Program (the Program) is a proven and sustainable strategy for disseminating cancer and poison control information to Asian and Pacific Islander (API) communities. This paper describes the process taken to identify health topics that can be readily addressed within the Program's infrastructure and reports results of the pilot testing of the educational module that was developed by following that process. The development of each new module is guided by the Health Belief Model and the Tipping Point Model. The process starts with the selection of a health topic demonstrating pressing need and treatment options in the API community. Then, using the Pareto principle, reasonably modifiable risk factors are chosen to be addressed in the module. "Sticky messaging" for the modifiable risk factors is developed to package the health information as memorable and transmissible calls-to-action. Finally, grocery store outreaches were used to pilot test the new module to assess its effectiveness at facilitating health care information to API community members. By adhering to the steps described in this paper, the authors were able to: (1) select liver cancer as a pressing API health issue that could be positively impacted by the Program; (2) identify reasonably modifiable risk factors for the chosen health issue; (3) generate compelling call-to-action messages to decrease risk of exposure; and (4) demonstrate the cultural and linguistic alignment of the liver cancer control module. The development and testing of new health education modules follow a methodical process guided by scientific principles. Understanding and employing the elements of an existing evidence-based and sustainable health education program can increase the likelihood of success in addressing the health needs of the API community. PMID:25971431

  12. A rehabilitation program for lung cancer patients during postthoracotomy chemotherapy

    Directory of Open Access Journals (Sweden)

    Hoffman AJ

    2014-03-01

    Full Text Available Amy J Hoffman,1 Ruth Ann Brintnall,2 Alexander von Eye,3 Lee W Jones,4 Gordon Alderink,5 Lawrence H Patzelt,6 Jean K Brown7 1College of Nursing, Michigan State University, East Lansing, MI, USA; 2Kirkhof College of Nursing, Grand Valley State University, Grand Rapids, MI, USA; 3Psychology Department, Michigan State University, East Lansing, MI, USA; 4Duke Center for Cancer Survivorship Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA; 5Frederik Meijer Honors College, Grand Valley State University, Grand Rapids, MI, USA; 6Spectrum Health, Grand Rapids, MI, USA and College of Human Medicine, Michigan State University, East Lansing, MI, USA; 7School of Nursing, University at Buffalo, the State University of New York, Buffalo, NY, USA Objective: The objective of this pilot study was to describe the effects of a 16-week home-based rehabilitative exercise program on cancer-related fatigue (CRF, other symptoms, functional status, and quality of life (QOL for patients with non-small cell lung cancer (NSCLC after thoracotomy starting within days after hospital discharge and continuing through the initiation and completion of chemotherapy. Materials and methods: Five patients with NSCLC completed the Brief Fatigue Inventory (measuring CRF severity and the MD Anderson Symptom Inventory (measuring symptom severity before and after thoractomy, and at the end of each week of the 16-week exercise program. Additionally, the Medical Outcomes Study Short Form-36 (measuring physical and mental functional status and the Quality of Life Index (measuring QOL were completed before and after thoracotomy, after weeks 3, 6, 12, and 16 (the end of the exercise program. Further, the 6-minute walk test (measuring functional capacity was administered before thoracotomy, prior to the initiation of chemotherapy and/or radiation therapy, and at the end of the 16-week exercise program, after completion of chemotherapy. Results: Participants had a

  13. Development of a Decommissioning Certificate Program

    International Nuclear Information System (INIS)

    A Decommissioning Certificate Program has been developed at Washington State University Tri-Cities (WSU TC) in conjunction with Bechtel Hanford, Inc. (BHI), and the U.S. Department of Energy (DOE)to address the increasing need for qualified professionals to direct and manage decommissioning projects. The cooperative effort between academia, industry, and government in the development and delivery of this Program of education and training is described, as well as the Program's design to prepare students to contribute sooner, and at a higher level, to decommissioning projects

  14. OpenCL parallel programming development cookbook

    CERN Document Server

    Tay, Raymond

    2013-01-01

    OpenCL Parallel Programming Development Cookbook will provide a set of advanced recipes that can be utilized to optimize existing code. This book is therefore ideal for experienced developers with a working knowledge of C/C++ and OpenCL.This book is intended for software developers who have often wondered what to do with that newly bought CPU or GPU they bought other than using it for playing computer games; this book is also for developers who have a working knowledge of C/C++ and who want to learn how to write parallel programs in OpenCL so that life isn't too boring.

  15. A youth development program: lasting impact.

    Science.gov (United States)

    Meltzer, Iris J; Fitzgibbon, James J; Leahy, Peter J; Petsko, Kathleen E

    2006-09-01

    The purpose of the study was to examine whether participation in a youth development program positively impacted participants' adult outcomes. Length of time adolescents spent in a comprehensive youth development program was correlated to their adult outcomes and functioning was assessed. All 141 adult past participants of a youth development program were identified. A survey was administered to 97% of the past participants located. School completion, higher education, alcohol and drug use, pregnancy and childbearing, employment, and involvement with the juvenile and adult justice systems were assessed. Degree of involvement in the program (low, medium, and high) was calculated and correlated with outcomes. Of the six areas surveyed, statistically significant findings (pcriminal justice. Nonsignificant, but positive, trends were observed in the areas of pregnancy/parenthood and illicit drug use. Best outcomes were achieved with those who participated for at least 201 days. PMID:16928844

  16. Cancer screening: Should cancer screening be essential component of primary health care in developing countries?

    OpenAIRE

    Saurabh Bobdey; Ganesh Balasubramanium; Abhinendra Kumar; Aanchal Jain

    2015-01-01

    Background: Cancer is a fatal disease and is on the rise across the globe. In India, breast, cervix and the oral cavity are the leading cancer sites, but, unfortunately, in-spite of availability of screening tools, there is no organized cancer screening program in India. The main objective of this study was to review the performance of various cancer screening modalities in a resource poor setting. Methods: MEDLINE and web of science electronic database was searched from January 1990 to D...

  17. Opinion of nurses regarding breast cancer screening programs

    Directory of Open Access Journals (Sweden)

    M Venkatramana

    2011-01-01

    Full Text Available Aim: Found to be effective in its treatment. The increased incidence of breast cancer supports the implementation of breast cancer screening programs. The present study evaluates the opinion among nurses regarding breast cancer screening programs in United Arab Emirates (UAE. Materials and Methods: The study population included 154 nurses practicing at different hospitals in United Arab Emirates (UAE, all nurses who participated in the breast cancer awareness programme organized by Gulf Medical University, Ajman, UAE. A self-administered, pretested, structured, close-ended questionnaire was used for data collection. Statistical Analysis was performed using Predictive Analytic Software (PASW 17. Results: The participants′ age ranged between 20 and 59 years. Fifty percent of the participants strongly agreed with the early detection of breast cancer by performing breast self examination. Thirty-nine percent were of the opinion that women aged 40 years and older should have a mammogram every year and continue to do so and 25.3% strongly felt that women in their 20s and 30s should have clinical breast examination as part of their periodic health examination by health professionals. 33.8% of the respondents strongly agree on providing information on the benefits and limitations of BSE to the female population. Twenty-six percent of the participants strongly agree that women at high risk should get magnetic resonance imaging and mammogram done every year. Conclusion: The present study indicates the need for providing workplace training programs thus equipping them with better knowledge and enhancing their service among the general population.

  18. Creating a “culture of research” in a community hospital: Strategies and tools from the National Cancer Institute Community Cancer Centers Program

    Science.gov (United States)

    St. Germain, Diane; Nacpil, Lianne M; Zaren, Howard A; Swanson, Sandra M; Minnick, Christopher; Carrigan, Angela; Denicoff, Andrea M; Igo, Kathleen E; Acoba, Jared D; Gonzalez, Maria M; McCaskill-Stevens, Worta

    2015-01-01

    Background The value of community-based cancer research has long been recognized. In addition to the National Cancer Institute’s Community Clinical and Minority-Based Oncology Programs established in 1983, and 1991 respectively, the National Cancer Institute established the National Cancer Institute Community Cancer Centers Program in 2007 with an aim of enhancing access to high-quality cancer care and clinical research in the community setting where most cancer patients receive their treatment. This article discusses strategies utilized by the National Cancer Institute Community Cancer Centers Program to build research capacity and create a more entrenched culture of research at the community hospitals participating in the program over a 7-year period. Methods To facilitate development of a research culture at the community hospitals, the National Cancer Institute Community Cancer Centers Program required leadership or chief executive officer engagement; utilized a collaborative learning structure where best practices, successes, and challenges could be shared; promoted site-to-site mentoring to foster faster learning within and between sites; required research program assessments that spanned clinical trial portfolio, accrual barriers, and outreach; increased identification and use of metrics; and, finally, encouraged research team engagement across hospital departments (navigation, multidisciplinary care, pathology, and disparities) to replace the traditionally siloed approach to clinical trials. Limitations The health-care environment is rapidly changing while complexity in research increases. Successful research efforts are impacted by numerous factors (e.g. institutional review board reviews, physician interest, and trial availability). The National Cancer Institute Community Cancer Centers Program sites, as program participants, had access to the required resources and support to develop and implement the strategies described. Metrics are an important

  19. Solar Heating and Cooling Development Program

    Science.gov (United States)

    Aaen, R.; Gossler, A.

    1984-01-01

    Heating is practical now, but cooling needs more development. Report describes program for design and development of solar heating and cooling systems having high performance, low cost and modular application. Describes main technical features of each of systems. Presents summary of performance and costs.

  20. The Development of Computer Music Programming Systems

    OpenAIRE

    Lazzarini, Victor

    2013-01-01

    This article traces the history and evolution of Music Programming, from the early off-line synthesis programs of the MUSIC N family to modern realtime interactive systems. It explores the main design characteristics of these systems and their impact on Computer Music. In chronological fashion, the article will examine, with code examples, the development of the early systems into the most common modern languages currently in use. In particular, we will focus on Csound, highlighting its main ...

  1. Development of a training assurance program

    International Nuclear Information System (INIS)

    The nuclear industry has made a significant commitment to improve training through the implementation of accredited performance-based training programs. Senior management expects that human performance will improve as a result of significant resource allocations. How do they know if training is effective in achieving improved human performance? Florida Power and Light Company is developing a Training Assurance Program to track indicators of training performance and future trends. Integrating the company's Quality Improvement Program processes with systematic training processes is resulting in personnel functioning in a proactive mode and increased customer satisfaction with training performance

  2. Ovarian Cancer Stroma: Pathophysiology and the Roles in Cancer Development

    International Nuclear Information System (INIS)

    Ovarian cancer represents one of the cancers with the worst prognostic in adult women. More than half of the patients who present with clinical signs such as abdominal bloating and a feeling of fullness already show advanced stages. The majority of ovarian cancers grow as cystic masses, and cancer cells easily spread into the pelvic cavity once the cysts rupture or leak. When the ovarian cancer cells disseminate into the peritoneal cavity, metastatic nests may grow in the cul-de-sac, and in more advanced stages, the peritoneal surfaces of the upper abdomen become the next largest soil for cancer progression. Ascites is also produced frequently in ovarian cancers, which facilitates distant metastasis. Clinicopathologic, epidemiologic and molecular studies on ovarian cancers have improved our understanding and therapeutic approaches, but still further efforts are required to reduce the risks in the patients who are predisposed to this lethal disease and the mortality of the patients in advanced stages. Among various molecules involved in ovarian carcinogenesis, special genes such as TP53, BRCA1 and BRCA2 have been well investigated. These genes are widely accepted as the predisposing factors that trigger malignant transformation of the epithelial cells of the ovary. In addition, adnexal inflammatory conditions such as chronic salpingitis and ovarian endometriosis have been great research interests in the context of carcinogenic background of ovarian cancers. In this review, I discuss the roles of stromal cells and inflammatory factors in the carcinogenesis and progression of ovarian cancers

  3. Ovarian Cancer Stroma: Pathophysiology and the Roles in Cancer Development

    Energy Technology Data Exchange (ETDEWEB)

    Furuya, Mitsuko [Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004 (Japan)

    2012-07-18

    Ovarian cancer represents one of the cancers with the worst prognostic in adult women. More than half of the patients who present with clinical signs such as abdominal bloating and a feeling of fullness already show advanced stages. The majority of ovarian cancers grow as cystic masses, and cancer cells easily spread into the pelvic cavity once the cysts rupture or leak. When the ovarian cancer cells disseminate into the peritoneal cavity, metastatic nests may grow in the cul-de-sac, and in more advanced stages, the peritoneal surfaces of the upper abdomen become the next largest soil for cancer progression. Ascites is also produced frequently in ovarian cancers, which facilitates distant metastasis. Clinicopathologic, epidemiologic and molecular studies on ovarian cancers have improved our understanding and therapeutic approaches, but still further efforts are required to reduce the risks in the patients who are predisposed to this lethal disease and the mortality of the patients in advanced stages. Among various molecules involved in ovarian carcinogenesis, special genes such as TP53, BRCA1 and BRCA2 have been well investigated. These genes are widely accepted as the predisposing factors that trigger malignant transformation of the epithelial cells of the ovary. In addition, adnexal inflammatory conditions such as chronic salpingitis and ovarian endometriosis have been great research interests in the context of carcinogenic background of ovarian cancers. In this review, I discuss the roles of stromal cells and inflammatory factors in the carcinogenesis and progression of ovarian cancers.

  4. Gene Expression Profiling Predicts the Development of Oral Cancer

    OpenAIRE

    Saintigny, Pierre; Zhang, Li; Fan, You-Hong; El-Naggar, Adel K.; Papadimitrakopoulou, Vali; Feng, Lei; Lee, J. Jack; Kim, Edward S.; Hong, Waun Ki; Mao, Li

    2011-01-01

    Patients with oral preneoplastic lesion (OPL) have high risk of developing oral cancer. Although certain risk factors such as smoking status and histology are known, our ability to predict oral cancer risk remains poor. The study objective was to determine the value of gene expression profiling in predicting oral cancer development. Gene expression profile was measured in 86 of 162 OPL patients who were enrolled in a clinical chemoprevention trial that used the incidence of oral cancer develo...

  5. Cancer control in developing countries: using health data and health services research to measure and improve access, quality and efficiency

    OpenAIRE

    Kangolle Alfred CT; Hanna Timothy P

    2010-01-01

    Abstract Background Cancer is a rapidly increasing problem in developing countries. Access, quality and efficiency of cancer services in developing countries must be understood to advance effective cancer control programs. Health services research can provide insights into these areas. Discussion This article provides an overview of oncology health services in developing countries. We use selected examples from peer-reviewed literature in health services research and relevant publicly availab...

  6. HUMID AIR TURBINE CYCLE TECHNOLOGY DEVELOPMENT PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    Richard Tuthill

    2002-07-18

    The Humid Air Turbine (HAT) Cycle Technology Development Program focused on obtaining HAT cycle combustor technology that will be the foundation of future products. The work carried out under the auspices of the HAT Program built on the extensive low emissions stationary gas turbine work performed in the past by Pratt & Whitney (P&W). This Program is an integral part of technology base development within the Advanced Turbine Systems Program at the Department of Energy (DOE) and its experiments stretched over 5 years. The goal of the project was to fill in technological data gaps in the development of the HAT cycle and identify a combustor configuration that would efficiently burn high moisture, high-pressure gaseous fuels with low emissions. The major emphasis will be on the development of kinetic data, computer modeling, and evaluations of combustor configurations. The Program commenced during the 4th Quarter of 1996 and closed in the 4th Quarter of 2001. It teamed the National Energy Technology Laboratory (NETL) with P&W, the United Technologies Research Center (UTRC), and a subcontractor on-site at UTRC, kraftWork Systems Inc. The execution of the program started with bench-top experiments that were conducted at UTRC for extending kinetic mechanisms to HAT cycle temperature, pressure, and moisture conditions. The fundamental data generated in the bench-top experiments was incorporated into the analytical tools available at P&W to design the fuel injectors and combustors. The NETL then used the hardware to conduct combustion rig experiments to evaluate the performance of the combustion systems at elevated pressure and temperature conditions representative of the HAT cycle. The results were integrated into systems analysis done by kraftWork to verify that sufficient understanding of the technology had been achieved and that large-scale technological application and demonstration could be undertaken as follow-on activity. An optional program extended the

  7. The impact of teaching development programs

    DEFF Research Database (Denmark)

    Rump, Camilla Østerberg; Christiansen, Frederik V; Trigwell, Keith

    University teaching development programs for academic staff typically have a range of different educational goals, ranging from gaining basic proficiency in teaching to the more fundamental goal of changing teachers’ conception of teaching towards student focused conceptions. In the current paper...... we shall explore the development of four dimensions of teacher development in a teaching development program (~10ECTS) at the University of Copenhagen. The two most important dimensions considered are the teachers’ conceptual change student focus (as measured by the Approaches to Teaching Inventory......), and the development of teachers’ self-efficacy beliefs with respect to teaching (as measured by a modified version of the Science Teaching Efficacy Belief Instrument). We find significant improvements with respect to both of these dimensions in several recent courses. No significant changes are found...

  8. Recent developments of the US RERTR program

    Energy Technology Data Exchange (ETDEWEB)

    Travelli, A.

    1983-01-01

    The status of the US Reduced Enrichment Research and Test Reactor (RERTR) Program is reviewed. After a brief outline of the RERTR Program objectives, goals and past accomplishments, emphasis is placed on the developments which took place during 1983 and on current program plans and schedules. Most program activities have proceeded as planned and a combination of two silicide fuels (U/sub 3/Si/sub 2/-Al and U/sub 3/Si-Al) was found to hold excellent promise for achieving the long-term program goals. A modification of the program plan, including the development and demonstration of those fuels, was prepared and is now being implemented. The uranium density of qualified RERTR fuels for plate-type reactors is forecasted to grow by approximately 1 g U/cm/sup 3/ each year, from the current 1.7 g U/cm/sup 3/ to the 7.0 g U/cm/sup 3/ which will be reached in 1988. The technical needs of research reactors for HEU exports are also forecasted to undergo a gradual and dramatic decline in the coming years.

  9. Recent developments of the US RERTR program

    International Nuclear Information System (INIS)

    The status of the US Reduced Enrichment Research and Test Reactor (RERTR) Program is reviewed. After a brief outline of the RERTR Program objectives, goals and past accomplishments, emphasis is placed on the developments which took place during 1983 and on current program plans and schedules. Most program activities have proceeded as planned and a combination of two silicide fuels (U3Si2-Al and U3Si-Al) was found to hold excellent promise for achieving the long-term program goals. A modification of the program plan, including the development and demonstration of those fuels, was prepared and is now being implemented. The uranium density of qualified RERTR fuels for plate-type reactors is forecasted to grow by approximately 1 g U/cm3 each year, from the current 1.7 g U/cm3 to the 7.0 g U/cm3 which will be reached in 1988. The technical needs of research reactors for HEU exports are also forecasted to undergo a gradual and dramatic decline in the coming years

  10. Identifying needs to develop a PBL staff development program

    OpenAIRE

    Prarthana Coffin

    2013-01-01

    Staff development is a crucial element for educational intervention. Recognizing the importance of staff development, this study aims to pin-point suitable methodologies in developing a Problem-Based Learning (PBL) academic staff development program for a higher education institute where PBL has become an intervention alternative. The study aims to answer the following research questions 1) how can university academic staff be assisted to acquire pedagogical competences for an initiative of t...

  11. Professional Development Programs for Teachers of English

    Directory of Open Access Journals (Sweden)

    Singgih Widodo

    2016-02-01

    Full Text Available Well-planned programs based on the needs for professional development of teachers are strongly needed to enhance the teaching-staff improvement.The impact of teacher improvement will effect the students learning and school achievement. This paper aims at raising awareness of English teachers to upgrade themselves as autonomous learners as well as researchers and broaden their horizon for stepping the ladder-career of their profession. For that purpose, a survey as reported here aimed to identify the needs of individual English teachers and the preferred programs for professional development. The findings indicated that the 36 teachers involved needed teacher training, teacher association, teacher materials, continuing education, and interschool visit and that teacher training was the most well known program among teachers.

  12. Development of an MPI benchmark program library

    International Nuclear Information System (INIS)

    Distributed parallel simulation software with message passing interfaces has been developed to realize large-scale and high performance numerical simulations. The most popular API for message communication is an MPI. The MPI will be provided on the Earth Simulator. It is known that performance of message communication using the MPI libraries gives a significant influence on a whole performance of simulation programs. We developed an MPI benchmark program library named MBL in order to measure the performance of message communication precisely. The MBL measures the performance of major MPI functions such as point-to-point communications and collective communications and the performance of major communication patterns which are often found in application programs. In this report, the description of the MBL and the performance analysis of the MPI/SX measured on the SX-4 are presented. (author)

  13. Promoting Breast Cancer Screening Among Asian American Women: the Asian Grocery Store-Based Cancer Education Program

    OpenAIRE

    Sadler, Georgia Robins; Beerman, Paula R.; Lee, Kathy; Hung, Jenny; Nguyen, Helene; Cho, Janet; Huang, Wennie

    2012-01-01

    Asian American women's historically low breast cancer mortality rate has remained constant as rates decreased for all other races. From 2000 to 2004, a randomized controlled trial explored the Asian grocery store-based breast cancer education program's impact on Chinese, Filipino, Korean, and Vietnamese women (n=1,540). Women aged 40 and older and non-adherent for annual screening mammograms were more likely to schedule a mammogram after receiving the breast cancer education program than wome...

  14. Receptivity and preferences of pancreatic cancer family members for participating in lifestyle programs to reduce cancer risk

    OpenAIRE

    Howell, Lisa A; Sinicrope, Pamela S.; Brockman, Tabetha A; Patten, Christi A.; Decker, Paul A.; Ehlers, Shawna L.; Nadeau, Ashley; Rabe, Kari G.; Breitkopf, Carmen Radecki; Petersen, Gloria M.

    2013-01-01

    Background Cancer is a shared family experience that might provide an opportunity for lifestyle change among at-risk family members. The purpose of this study was to assess receptivity and preferences for cancer risk reduction programs among at-risk family members with two or more relatives affected with pancreas cancer. Methods We surveyed 401 at-risk family members in an existing pancreatic cancer family registry. Participants completed a mailed survey which examined demographic, medical, a...

  15. Research and Development Conference CIEE Program 1992

    Energy Technology Data Exchange (ETDEWEB)

    1992-11-01

    CIEE`s second annual Research and Development Conference will introduce you to some of the results achieved to date through CIEE-sponsored multiyear research performed in three programs: Building Energy Efficiency, Air Quality Impacts of Energy Efficiency, and End-Use Resource Planning. Results from scoping studies, Director`s discretionary research, and exploratory research will also be featured in this report.

  16. 78 FR 49374 - Rural Development Voucher Program

    Science.gov (United States)

    2013-08-14

    ... Act of 1995, RHS is now seeking OMB approval of the reporting and recordkeeping requirements contained... Rental Housing Program who may be subject to an increase in their rents after prepayment of the Section... Housing Act); voucher value calculation method (Housing and Urban Development section 8 market...

  17. Developing a Systematic Patent Search Training Program

    Science.gov (United States)

    Zhang, Li

    2009-01-01

    This study aims to develop a systematic patent training program using patent analysis and citation analysis techniques applied to patents held by the University of Saskatchewan. The results indicate that the target audience will be researchers in life sciences, and aggregated patent database searching and advanced search techniques should be…

  18. The AECL research and development program

    International Nuclear Information System (INIS)

    The research and development program of the Atomic Energy of Canada Research Company is briefly described. Goals and objectives are emphasized, some recent highlights are given and the importance of technology transfer is discussed. A short representative bibliography is included. (auth)

  19. RIF's Guide to Developing a Program.

    Science.gov (United States)

    Smithsonian Institution, Washington, DC.

    The Reading is FUNdamental program is funded by the Ford Foundation and sponsored by the Smithsonian Institution. Its advisory board is composed of people from diverse fields. It is designed to motivate children to read through experiencing the joy and pride of owning books of their own choice, and its purpose is to help develop and give technical…

  20. Immunologic checkpoints in cancer therapy: focus on the programmed death-1 (PD-1 receptor pathway

    Directory of Open Access Journals (Sweden)

    Momtaz P

    2014-11-01

    Full Text Available Parisa Momtaz,1,2 Michael A Postow1,2 1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; 2Weill Cornell Medical College, New York, NY, USA Abstract: T-lymphocytes have the potential to recognize cancer antigens as foreign and therefore eliminate them. However, immune checkpoints such as cytotoxic T-lymphocyte-associated antigen (CTLA-4 and programmed cell death (PD-1 receptor and its ligands (PD-L1, PD-L2 suppress the activity of T-lymphocytes. Advances in the understanding of immunology and its role in cancer have led to the development of immune checkpoint inhibitors that block CTLA-4 and PD-1 and result in durable responses in patients with a wide range of cancers. PD-1 and PD-L1 inhibitors are currently in many stages of clinical investigation, and the anti-PD-1 antibody, pembrolizumab, was recently approved by the US Food and Drug Administration. Many questions remain to be answered, such as the optimal administration schedule, biomarkers that associate with benefit, and potential for use of PD-1 agents in combination approaches. Nonetheless, immunotherapy with PD-1 blocking antibodies is now becoming an integral part in the management of cancer. Keyword: immune checkpoints, immunotherapy, programmed cell death protein-1, cytotoxic T-lymphocyte antigen 4

  1. Programmed death-1 & its ligands: promising targets for cancer immunotherapy.

    Science.gov (United States)

    Shrimali, Rajeev K; Janik, John E; Abu-Eid, Rasha; Mkrtichyan, Mikayel; Khleif, Samir N

    2015-01-01

    Novel strategies for cancer treatment involving blockade of immune inhibitors have shown significant progress toward understanding the molecular mechanism of tumor immune evasion. The preclinical findings and clinical responses associated with programmed death-1 (PD-1) and PD-ligand pathway blockade seem promising, making these targets highly sought for cancer immunotherapy. In fact, the anti-PD-1 antibodies, pembrolizumab and nivolumab, were recently approved by the US FDA for the treatment of unresectable and metastatic melanoma resistant to anticytotoxic T-lymphocyte antigen-4 antibody (ipilimumab) and BRAF inhibitor. Here, we discuss strategies of combining PD-1/PD-ligand interaction inhibitors with other immune checkpoint modulators and standard-of-care therapy to break immune tolerance and induce a potent antitumor activity, which is currently a research area of key scientific pursuit. PMID:26250412

  2. Identifying needs to develop a PBL staff development program

    Directory of Open Access Journals (Sweden)

    Prarthana Coffin

    2013-08-01

    Full Text Available Staff development is a crucial element for educational intervention. Recognizing the importance of staff development, this study aims to pin-point suitable methodologies in developing a Problem-Based Learning (PBL academic staff development program for a higher education institute where PBL has become an intervention alternative. The study aims to answer the following research questions 1 how can university academic staff be assisted to acquire pedagogical competences for an initiative of the implementation of PBL curriculum? 2 What kinds of support do university academic staff need in order to maintain PBL implementation? Through a combination of a literature review, interviews with 6 PBL experts which emphasize the importance of PBL facilitators, and document analysis of reflection notes from 18 trainees of a PBL workshop, this study will produce a guideline in developing a PBL Academic Staff Development Program for an institute wishes to implement and retain PBL as the education strategy.

  3. Transcriptional programs activated by exposure of human prostate cancer cells to androgen

    OpenAIRE

    DePrimo, Samuel E; Diehn, Maximilian; Nelson, Joel B.; Reiter, Robert E.; Matese, John; Fero, Mike; Tibshirani, Robert; Brown, Patrick O; James D Brooks

    2002-01-01

    Background Androgens are required for both normal prostate development and prostate carcinogenesis. We used DNA microarrays, representing approximately 18,000 genes, to examine the temporal program of gene expression following treatment of the human prostate cancer cell line LNCaP with a synthetic androgen. Results We observed statistically significant changes in levels of transcripts of more than 500 genes. Many of these genes were previously reported androgen targets, but most were not prev...

  4. Improving clinical research and cancer care delivery in community settings: evaluating the NCI community cancer centers program

    Directory of Open Access Journals (Sweden)

    Fennell Mary L

    2009-09-01

    Full Text Available Abstract Background In this article, we describe the National Cancer Institute (NCI Community Cancer Centers Program (NCCCP pilot and the evaluation designed to assess its role, function, and relevance to the NCI's research mission. In doing so, we describe the evolution of and rationale for the NCCCP concept, participating sites' characteristics, its multi-faceted aims to enhance clinical research and quality of care in community settings, and the role of strategic partnerships, both within and outside of the NCCCP network, in achieving program objectives. Discussion The evaluation of the NCCCP is conceptualized as a mixed method multi-layered assessment of organizational innovation and performance which includes mapping the evolution of site development as a means of understanding the inter- and intra-organizational change in the pilot, and the application of specific evaluation metrics for assessing the implementation, operations, and performance of the NCCCP pilot. The assessment of the cost of the pilot as an additional means of informing the longer-term feasibility and sustainability of the program is also discussed. Summary The NCCCP is a major systems-level set of organizational innovations to enhance clinical research and care delivery in diverse communities across the United States. Assessment of the extent to which the program achieves its aims will depend on a full understanding of how individual, organizational, and environmental factors align (or fail to align to achieve these improvements, and at what cost.

  5. Peralta Cancer Research Institute

    International Nuclear Information System (INIS)

    The investigators in the cell biology program at PCRI have pioneered in the development of techniques for culturing human epithelial cells. The cancer diagnosis program has been concerned with researching new techniques for early diagnosis of breast cancer in women. The cancer treatment program has been concerned with applying cell biology and biochemistry advances to improve cancer management

  6. Maximizing Benefits for Effective Cancer Survivorship Programming: Defining a Dissemination and Implementation Plan

    OpenAIRE

    Wolin, Kathleen Y.; Colditz, Graham A.; Proctor, Enola K.

    2011-01-01

    The latest in implementation science is used to outline a process that cancer organizations can use in designing, implementing, prioritizing, and evaluating cancer survivor programs to improve patient outcomes, using smoking cessation as a primary example.

  7. Processed pseudogenes acquired somatically during cancer development

    OpenAIRE

    Cooke, Susanna L.; Shlien, Adam; Marshall, John; Pipinikas, Christodoulos P; Martincorena, Inigo; Tubio, Jose M. C.; Li, Yilong; Menzies, Andrew; Mudie, Laura; Ramakrishna, Manasa; Yates, Lucy; Davies, Helen; Bolli, Niccolo; Bignell, Graham R; Tarpey, Patrick S.

    2014-01-01

    Cancer evolves by mutation, with somatic reactivation of retrotransposons being one such mutational process. Germline retrotransposition can cause processed pseudogenes, but whether this occurs somatically has not been evaluated. Here we screen sequencing data from 660 cancer samples for somatically acquired pseudogenes. We find 42 events in 17 samples, especially non-small cell lung cancer (5/27) and colorectal cancer (2/11). Genomic features mirror those of germline LINE element retrotransp...

  8. Bioenergy Feedstock Development Program Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Kszos, L.A.

    2001-02-09

    The U.S. Department of Energy's (DOE's) Bioenergy Feedstock Development Program (BFDP) at Oak Ridge National Laboratory (ORNL) is a mission-oriented program of research and analysis whose goal is to develop and demonstrate cropping systems for producing large quantities of low-cost, high-quality biomass feedstocks for use as liquid biofuels, biomass electric power, and/or bioproducts. The program specifically supports the missions and goals of DOE's Office of Fuels Development and DOE's Office of Power Technologies. ORNL has provided technical leadership and field management for the BFDP since DOE began energy crop research in 1978. The major components of the BFDP include energy crop selection and breeding; crop management research; environmental assessment and monitoring; crop production and supply logistics operational research; integrated resource analysis and assessment; and communications and outreach. Research into feedstock supply logistics has recently been added and will become an integral component of the program.

  9. Laboratory Directed Research ampersand Development Program

    International Nuclear Information System (INIS)

    At Brookhaven National Laboratory the Laboratory Directed Research and Development (LDRD) Program is a discretionary research and development tool critical in maintaining the scientific excellence and vitality of the laboratory. It is also a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor in achieving and maintaining staff excellence, and a means to address national needs, within the overall mission of the Department of Energy and Brookhaven National Laboratory. This report summarizes research which was funded by this program during fiscal year 1993. The research fell in a number of broad technical and scientific categories: new directions for energy technologies; global change; radiation therapies and imaging; genetic studies; new directions for the development and utilization of BNL facilities; miscellaneous projects. Two million dollars in funding supported 28 projects which were spread throughout all BNL scientific departments

  10. Target developments program to prepare LMJ campaigns

    International Nuclear Information System (INIS)

    To carry out laser plasma experiments on CEA laser facilities, a R and D program was set up and is still under way to deliver complex targets. For a decade, specific developments are also dedicated to 'Ligne d'Integration Laser' (LIL) in France and Omega facilities (USA). To prepare the targets intended for the first experiments on the Laser 'Megajoule' (LMJ) facility, new developments are required, such as cocktail hohlraum fabrication, gas barrier coating and foam shells developments. For fusion experiments on LMJ, an important program is also under way to elaborate the Cryogenic Target Assembly (CTA), to fill and transport the CTA and to study the conformation process of the DT layer.

  11. Integrated rural development programs: a skeptical perspective.

    Science.gov (United States)

    Ruttan, V W

    1975-11-01

    In examining integrated rural development programs the question that arises is why is it possible to identify several relatively successful small-scale or pilot rural development projects yet so difficult to find examples of successful rural development programs. 3 bodies of literature offer some insight into the morphology of rural development projects, programs, and processes: the urban-industrial impact hypothesis; the theory of induced technical change; and the new models of institutional change that deal with institution building and the economics of bureaucratic behavior. The urban-industrial impact hypothesis helps in the clarification of the relationships between the development of rural areas and the development of the total society of which rural areas are a part. It is useful in understanding the spatial dimensions of rural development where rural development efforts are likely to be most successful. Formulation of the hypothesis generated a series of empirical studies designed to test its validity. The effect of these studies has been the development of a rural development model in which the rural community is linked to the urban-industrial economy through a series of market relationships. Both the urban economy's rate of growth and the efficiency of the intersector product and factor markets place significant constraints on the possibilities of rural area development. It is not possible to isolate development processes in the contemporary rural community in a developing society from development processes in the larger society. The induced technical change theory provides a guide as to what must be done to gain access to efficient sources of economic growth, the new resources and incomes that are necessary to sustain rural development. Design of a successful rural development strategy involves a combination of technical and institutional change. The ability of rural areas to respond to the opportunities for economic growth generated by local urban

  12. Cancer Control Planners’ Perceptions and Use of Evidence-Based Programs

    OpenAIRE

    Hannon, Peggy A.; Maria E. Fernandez; Williams, Rebecca; Mullen, Patricia Dolan; Escoffery, Cam; Kreuter, Matthew W.; Pfeiffer, Debra; Kegler, Michelle C.; Reese, LeRoy; Mistry, Ritesh; Bowen, Deborah J.

    2010-01-01

    The Cancer Prevention and Control Research Network (CPCRN) surveyed 282 cancer control planners to inform its efforts to increase the use of evidence-based cancer control programs (EBPs; programs that have been scientifically tested and successfully changed behavior). Respondents included planners from organizations in state Comprehensive Cancer Control coalitions as well as other governmental and non-governmental organizations, and community-based coalitions. Respondents provided information...

  13. Association of the California tobacco control program with declines in lung cancer incidence

    OpenAIRE

    Barnoya, J; Glantz, Stanton A. Ph.D.

    2004-01-01

    Objective: The California tobacco control program enacted in 1988 has been associated with declines in smoking and heart disease mortality. Since smoking also causes lung cancer, we investigated whether the program was associated with a decline in lung and other cancer incidence. Methods: Age-adjusted incidence rates of lung and bladder cancer (which are caused by smoking) and prostate and brain cancer (which are not) in the San Francisco-Oakland (SFO) Surveillance Epidemiology End Results (S...

  14. Java programming for Android developers for dummies

    CERN Document Server

    Burd , Barry

    2013-01-01

    Get started creating Android apps with Java in no time! The demand for Android apps is not slowing down but many mobile developers who want to create Android apps lack the necessary Java background. This beginner guide gets you up and running with using Java to create Android apps with no prior knowledge or experienced necessary! Shows you the basic Java development concepts and techniques that are necessary to develop Android appsExplores what goes into creating an Android app to give you a better understanding of the various elementsAddresses how to deal with standard programming challenges

  15. NP-MHTGR Fuel Development Program Results

    Energy Technology Data Exchange (ETDEWEB)

    Maki, John Thomas; Petti, David Andrew; Hobbins, Richard Redfield; McCardell, Richard K.; Shaber, Eric Lee; Southworth, Finis Hio

    2002-10-01

    In August 1988, the Secretary of Energy announced a strategy to acquire New Production Reactor capacity for producing tritium. The strategy involved construction of a New Production Modular High Temperature Gas-Cooled Reactor (NP-MHTGR) where the Idaho National Engineering and Environmental Laboratory (INEEL) was selected as the Management and Operations contractor for the project. Immediately after the announcement in August 1988, tritium target particle development began with the INEEL selected as the lead laboratory. Fuel particle development was initially not considered to be on a critical path for the project, therefore, the fuel development program was to run concurrently with the design effort of the NP-MHTGR.

  16. Tubular solid oxide fuel cell development program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-08-01

    This paper presents an overview of the Westinghouse Solid Oxide Fuel Cell (SOFC) development activities and current program status. The Westinghouse goal is to develop a cost effective cell that can operate for 50,000 to 100,000 hours. Progress toward this goal will be discussed and test results presented for multiple single cell tests which have now successfully exceeded 56,000 hours of continuous power operation at temperature. Results of development efforts to reduce cost and increase power output of tubular SOFCs are described.

  17. European Community's program in marine resources development

    International Nuclear Information System (INIS)

    The European Community launched already several research program in the different fields of social and industrial activities. The Fourth Framework Programme is divided into 4 main activities comporting a total of 18 programs. These programs are dealing with general topics as information and communication, industrial technologies, environment, life sciences and technologies, energy, transport and socioeconomic research. One line is devoted to marine sciences and technology, but offshore activities could also be included in the other topics as offshore oil and gas in energy, ship building and harbor in transport, aquaculture and fisheries in life sciences and technology, etc. In order to maintain a coherent approach toward offshore activities, the European maritime industries met intensively front 1991 to 1994 and recommended a series of proposal for Research and Development of marine resources. The methodology and content of these proposals is exposed

  18. Recent developments and innovations in gastric cancer

    OpenAIRE

    Mihmanli, Mehmet; Ilhan, Enver; Idiz, Ufuk Oguz; ALEMDAR, Ali; Demir, Uygar

    2016-01-01

    Gastric cancer has an important place in the worldwide incidence of cancer and cancer-related deaths. It can metastasize to the lymph nodes in the early stages, and lymph node metastasis is an important prognostic factor. Surgery is a very important part of gastric cancer treatment. A D2 lymphadenectomy is the standard surgical treatment for cT1N+ and T2-T4 cancers, which are potentially curable. Recently, the TNM classification system was reorganized, and the margins for gastrectomy and lymp...

  19. Programmed activation of cancer cell apoptosis: A tumor-targeted phototherapeutic topoisomerase I inhibitor

    Science.gov (United States)

    Shin, Weon Sup; Han, Jiyou; Kumar, Rajesh; Lee, Gyung Gyu; Sessler, Jonathan L.; Kim, Jong-Hoon; Kim, Jong Seung

    2016-07-01

    We report here a tumor-targeting masked phototherapeutic agent 1 (PT-1). This system contains SN-38—a prodrug of the topoisomerase I inhibitor irinotecan. Topoisomerase I is a vital enzyme that controls DNA topology during replication, transcription, and recombination. An elevated level of topoisomerase I is found in many carcinomas, making it an attractive target for the development of effective anticancer drugs. In addition, PT-1 contains both a photo-triggered moiety (nitrovanillin) and a cancer targeting unit (biotin). Upon light activation in cancer cells, PT-1 interferes with DNA re-ligation, diminishes the expression of topoisomerase I, and enhances the expression of inter alia mitochondrial apoptotic genes, death receptors, and caspase enzymes, inducing DNA damage and eventually leading to apoptosis. In vitro and in vivo studies showed significant inhibition of cancer growth and the hybrid system PT-1 thus shows promise as a programmed photo-therapeutic (“phototheranostic”).

  20. SIMS analysis: Development and evaluation program summary

    International Nuclear Information System (INIS)

    This report provides an overview of the ''SIMS Analysis: Development and Evaluation Program'', which was executed at the Idaho National Engineering Laboratory from mid-FY-92 to the end of FY-96. It should be noted that prior to FY-1994 the name of the program was ''In-Situ SIMS Analysis''. This report will not go into exhaustive detail regarding program accomplishments, because this information is contained in annual reports which are referenced herein. In summary, the program resulted in the design and construction of an ion trap secondary ion mass spectrometer (IT-SIMS), which is capable of the rapid analysis of environmental samples for adsorbed surface contaminants. This instrument achieves efficient secondary ion desorption by use of a molecular, massive ReO4- primary ion particle. The instrument manages surface charge buildup using a self-discharging principle, which is compatible with the pulsed nature of the ion trap. The instrument can achieve high selectivity and sensitivity using its selective ion storage and MS/MS capability. The instrument was used for detection of tri-n-butyl phosphate, salt cake (tank cake) characterization, and toxic metal speciation studies (specifically mercury). Technology transfer was also an important component of this program. The approach that was taken toward technology transfer was that of component transfer. This resulted in transfer of data acquisition and instrument control software in FY-94, and ongoing efforts to transfer primary ion gun and detector technology to other manufacturers

  1. Laboratory Directed Research and Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Ogeka, G.J.

    1991-12-01

    Today, new ideas and opportunities, fostering the advancement of technology, are occurring at an ever-increasing rate. It, therefore, seems appropriate that a vehicle be available which fosters the development of these new ideas and technologies, promotes the early exploration and exploitation of creative and innovative concepts, and which develops new fundable'' R D projects and programs. At Brookhaven National Laboratory (BNL), one such method is through its Laboratory Directed Research and Development (LDRD) Program. This discretionary research and development tool is critical in maintaining the scientific excellence and vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor achieving and maintaining staff excellence, and a means to address national needs, with the overall mission of the Department of Energy (DOE) and the Brookhaven National Laboratory. The Project Summaries with their accomplishments described in this report reflect the above. Aside from leading to new fundable or promising programs and producing especially noteworthy research, they have resulted in numerous publications in various professional and scientific journals, and presentations at meetings and forums.

  2. IAEA Nuclear Security Human Resource Development Program

    International Nuclear Information System (INIS)

    The IAEA is at the forefront of international efforts to strengthen the world's nuclear security framework. The current Nuclear Security Plan for 2006-2009 was approved by the IAEA Board of Governors in September 2005. This Plan has three main points of focus: needs assessment, prevention, detection and response. Its overall objective is to achieve improved worldwide security of nuclear and other radioactive material in use, storage and transport, and of their associated facilities. This will be achieved, in particular, through the provision of guidelines and recommendations, human resource development, nuclear security advisory services and assistance for the implementation of the framework in States, upon request. The presentation provides an overview of the IAEA nuclear security human resource development program that is divided into two parts: training and education. Whereas the training program focuses on filling gaps between the actual performance of personnel working in the area of nuclear security and the required competencies and skills needed to meet the international requirements and recommendations described in UN and IAEA documents relating to nuclear security, the Educational Program in Nuclear Security aims at developing nuclear security experts and specialists, at fostering a nuclear security culture and at establishing in this way sustainable knowledge in this field within a State. The presentation also elaborates on the nuclear security computer based learning component and provides insights into the use of human resource development as a tool in achieving the IAEA's long term goal of improving sustainable nuclear security in States. (author)

  3. Guidelines for developing vectorizable computer programs

    Science.gov (United States)

    Miner, E. W.

    1982-01-01

    Some fundamental principles for developing computer programs which are compatible with array-oriented computers are presented. The emphasis is on basic techniques for structuring computer codes which are applicable in FORTRAN and do not require a special programming language or exact a significant penalty on a scalar computer. Researchers who are using numerical techniques to solve problems in engineering can apply these basic principles and thus develop transportable computer programs (in FORTRAN) which contain much vectorizable code. The vector architecture of the ASC is discussed so that the requirements of array processing can be better appreciated. The "vectorization" of a finite-difference viscous shock-layer code is used as an example to illustrate the benefits and some of the difficulties involved. Increases in computing speed with vectorization are illustrated with results from the viscous shock-layer code and from a finite-element shock tube code. The applicability of these principles was substantiated through running programs on other computers with array-associated computing characteristics, such as the Hewlett-Packard (H-P) 1000-F.

  4. Advocacy resource: engaging the media and promoting your cancer program in Africa

    OpenAIRE

    Reams, R Renee; Odedina, Folakemi T; Pressey, Shannon

    2013-01-01

    To address the need for a significant increase in cancer advocacy programs in Africa, the University of Florida (UF), the Prostate Net, and the African Organization for Research and Training in Cancer (AORTIC) co-hosted the first biennial International Workshop on Cancer Advocacy for African Countries (CAAC) on November 29, 2011, one-day prior to AORTIC’s 8th International Cancer Conference in Cairo, Egypt. Over 70 African cancer advocates representing about 12 African countries participated ...

  5. Oral cancer in Libya and development of regional oral cancer registries: A review

    OpenAIRE

    BenNasir, E.; El Mistiri, M.; Mcgowan, R.; Katz, R.V.

    2015-01-01

    The aims of this paper are three-fold: (1) to summarize the current epidemiological data on oral cancer in Libya as reported in the published literature and as compared to other national oral cancer rates in the region; (2) to present both the history of the early development, and future goals, of population-based oral cancer tumor registries in Libya as they partner with the more established regional and international population-based cancer tumor registries; and, (3) to offer recommendation...

  6. Clean Technology Evaluation & Workforce Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Patricia Glaza

    2012-12-01

    The overall objective of the Clean Technology Evaluation portion of the award was to design a process to speed up the identification of new clean energy technologies and match organizations to testing and early adoption partners. The project was successful in identifying new technologies targeted to utilities and utility technology integrators, in developing a process to review and rank the new technologies, and in facilitating new partnerships for technology testing and adoption. The purpose of the Workforce Development portion of the award was to create an education outreach program for middle & high-school students focused on clean technology science and engineering. While originally targeting San Diego, California and Cambridge, Massachusetts, the scope of the program was expanded to include a major clean technology speaking series and expo as part of the USA Science & Engineering Festival on the National Mall in Washington, D.C.

  7. NCI Approves Funding Plan for NCI Community Oncology Research Program (NCORP) | Division of Cancer Prevention

    Science.gov (United States)

    On June 24, 2014, the Scientific Program Leaders (SPL) of the National Cancer Institute (NCI) approved the funding plan for the NCI Community Oncology Research Program (NCORP), a national network of investigators, cancer care providers, academic institutions, and other organizations. NCORP will conduct multi-site cancer clinical trials and studies in diverse populations in community-based healthcare systems across the United States. The program will receive $93 million a year for five years. |

  8. Establishing and Sustaining a Prospective Screening Program for Breast Cancer-Related Lymphedema at the Massachusetts General Hospital: Lessons Learned

    Directory of Open Access Journals (Sweden)

    Cheryl Brunelle

    2015-05-01

    Full Text Available There has been an increasing call to prospectively screen patients with breast cancer for the development of breast cancer-related lymphedema (BCRL following their breast cancer treatment. While the components of a prospective screening program have been published, some centers struggle with how to initiate, establish, and sustain a screening program of their own. The intent of this manuscript is to share our experience and struggles in establishing a prospective surveillance program within the infrastructure of our institution. It is our hope that by sharing our history other centers can learn from our mistakes and successes to better design their own prospective screening program to best serve their patient population.

  9. [Shared decision making in the colorectal cancer screening program in the canton of Vaud].

    Science.gov (United States)

    Auer, Reto; Selby, Kevin; Bulliard, Jean-Luc; Nichita, Christina; Dorta, Gian; Ducros, Cyril; Cornuz, Jacques

    2015-11-25

    The colorectal cancer screening program of the canton of Vaud aims to facilitate screening for this cancer for the population aged 50 to 69 years old. The two screening modalities offered are fecal immunochemical testing (FIT) and colonoscopy. The decision to undergo screening and the screening modality is based on an individual medical encounter with a primary care physician. Both screening modalities are reimbursed through basic health coverage in Switzerland. The participation to the screening program allows the exemption of the deductible for the medical encounter and the chosen screening modality. A copay of 10% is maintained for all costs. Communication tools were developed on the basis of recommendations in the literature to facilitate shared decision-making in a medical encounter. PMID:26742350

  10. Research and Development Conference CIEE Program 1992

    Energy Technology Data Exchange (ETDEWEB)

    1992-01-01

    CIEE's second annual Research and Development Conference will introduce you to some of the results achieved to date through CIEE-sponsored multiyear research performed in three programs: Building Energy Efficiency, Air Quality Impacts of Energy Efficiency, and End-Use Resource Planning. Results from scoping studies, Director's discretionary research, and exploratory research will also be featured in this report.

  11. Programmed cell death during quinoa perisperm development

    OpenAIRE

    López-Fernández, María Paula; Maldonado, Sara

    2013-01-01

    At seed maturity, quinoa (Chenopodium quinoa Willd.) perisperm consists of uniform, non-living, thin-walled cells full of starch grains. The objective of the present study was to study quinoa perisperm development and describe the programme of cell death that affects the entire tissue. A number of parameters typically measured during programmed cell death (PCD), such as cellular morphological changes in nuclei and cytoplasm, endoreduplication, DNA fragmentation, and the participation of nucle...

  12. Understanding cervical cancer in the context of developing countries

    Directory of Open Access Journals (Sweden)

    Farhad Ali

    2012-01-01

    Full Text Available Cancer is one of the leading causes of deaths worldwide. Among the women, gynecological cancers are most common. Cervical cancer is a main gynecological cancer of the women. The global burden of cervical cancer is disproportionately high among the developing countries where 85 per cent of the estimated 493, 000 new cases and 273, 000 deaths occur worldwide. There are several dimensions of the problem. Cervical cancer is a problem where people are poor, where the socio-economic status of the women is low and sometimes specific ethnicity also posses additional risk to the women to develop cervical cancer. Human papillomavirus infection is a main risk factor for the cervical cancer however there are some other factors which increase the risk. Among them some are number of sexual partners, age of first sexual intercourse, infection of sexually transmitted diseases, use of hormonal contraceptives, parity, age, smoking, food and diet. Apart from these factors, some other issues, such as policy on cancer, capacity of health system, socio-economic and cultural factors and awareness among the women are also associated with the cervical cancer related morbidity and mortality across the developing countries. There some interventions which give promising results in terms of reducing cervical cancer related morbidity and mortality. Among them visual inspection of cervix with acetic acid followed by treatment is one such effective method.

  13. Randomised controlled trial of a supervised exercise rehabilitation program for colorectal cancer survivors immediately after chemotherapy: study protocol

    OpenAIRE

    Eakin Elizabeth G; Heesch Kristiann C; Spence Rosalind R; Brown Wendy J

    2007-01-01

    Abstract Background Colorectal cancer (CRC) diagnosis and the ensuing treatments can have a substantial impact on the physical and psychological health of survivors. As the number of CRC survivors increases, so too does the need to develop viable rehabilitation programs to help these survivors return to good health as quickly as possible. Exercise has the potential to address many of the adverse effects of CRC treatment; however, to date, the role of exercise in the rehabilitation of cancer p...

  14. Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials).

    Science.gov (United States)

    Crawford, Jeffrey; Prado, Carla M M; Johnston, Mary Ann; Gralla, Richard J; Taylor, Ryan P; Hancock, Michael L; Dalton, James T

    2016-06-01

    Muscle wasting in cancer is a common and often occult condition that can occur prior to overt signs of weight loss and before a clinical diagnosis of cachexia can be made. Muscle wasting in cancer is an important and independent predictor of progressive functional impairment, decreased quality of life, and increased mortality. Although several therapeutic agents are currently in development for the treatment of muscle wasting or cachexia in cancer, the majority of these agents do not directly inhibit muscle loss. Selective androgen receptor modulators (SARMs) have the potential to increase lean body mass (LBM) and hence muscle mass, without the untoward side effects seen with traditional anabolic agents. Enobosarm, a nonsteroidal SARM, is an agent in clinical development for prevention and treatment of muscle wasting in patients with cancer (POWER 1 and 2 trials). The POWER trials are two identically designed randomized, double-blind, placebo-controlled, multicenter, and multinational phase 3 trials to assess the efficacy of enobosarm for the prevention and treatment of muscle wasting in subjects initiating first-line chemotherapy for non-small-cell lung cancer (NSCLC). To assess enobosarm's effect on both prevention and treatment of muscle wasting, no minimum weight loss is required. These pivotal trials have pioneered the methodological and regulatory fields exploring a therapeutic agent for cancer-associated muscle wasting, a process hereby described. In each POWER trial, subjects will receive placebo (n = 150) or enobosarm 3 mg (n = 150) orally once daily for 147 days. Physical function, assessed as stair climb power (SCP), and LBM, assessed by dual-energy X-ray absorptiometry (DXA), are the co-primary efficacy endpoints in both trials assessed at day 84. Based on extensive feedback from the US Food and Drug Administration (FDA), the co-primary endpoints will be analyzed as a responder analysis. To be considered a physical function responder, a

  15. Discovery and development of sulforaphane as a cancer chemopreventive phytochemical

    Institute of Scientific and Technical Information of China (English)

    Yuesheng ZHANG; Li TANG

    2007-01-01

    Sulforaphane (SF) is a phytochemical that displays both anticarcinogenic and anticancer activity. SF modulates many cancer-related events, including suscep-tibility to carcinogens, cell death, cell cycle, angiogenesis, invasion and metastasis.We review its discovery and development as a cancer chemopreventive agent with the intention of encouraging further research on this important compound and facilitating the identification and development of new phytochemicals for cancer prevention.

  16. Professional development for nuclear power programs in developing countries

    International Nuclear Information System (INIS)

    Countries entering nuclear power programs for the first time find that inadequate planning for the development of trained manpower is a critical factor in the success of their programs. This requires the early training of a team for the planning and acquisition effort to be followed by training for the supervision of construction. In addition, there is the more readily recognized training for operation. Typical manpower needs for such projects have been documented by the International Atomic Energy Agency. The basic academic training of engineers and scientists, which should be available within the country; advanced academic training, which is often secured in institutions abroad; specialized training abroad by international agencies; specialized training by the vendors of nuclear equipment; and the development of indigenous training. This paper outlines all of these avenues but will concentrate on the training available through international agencies and on the development of indigenous training capability

  17. Occurrence of Breast Cancer After Chest Wall Irradiation for Pediatric Cancer, as Detected by a Multimodal Screening Program

    Energy Technology Data Exchange (ETDEWEB)

    Terenziani, Monica [Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy); Casalini, Patrizia [Molecular Biology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy); Scaperrotta, Gianfranco; Gandola, Lorenza; Trecate, Giovanna [Radiology and Radiotherapy Departments, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy); Catania, Serena; Cefalo, Graziella [Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy); Conti, Alberto [Breast Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy); Massimino, Maura; Meazza, Cristina; Podda, Marta; Spreafico, Filippo [Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy); Suman, Laura [Radiology and Radiotherapy Departments, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy); Gennaro, Massimiliano, E-mail: gennaromassimiliano@istitutotumori.mi.it [Breast Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano (Italy)

    2013-01-01

    Purpose: To assess the occurrence of breast cancer (BC) after exposure to ionizing radiation for pediatric cancer, by means of a multimodal screening program. Patients and Methods: We identified 86 patients who had received chest wall radiation therapy for pediatric cancer. Clinical breast examination (CBE), ultrasound (US), and mammography (MX) were performed yearly. Magnetic resonance imaging (MRI) was added as of October 2007. We calculated the risk of developing BC by radiation therapy dose, patient age, and menarche before or after primary treatment. Results: Eleven women developed a BC from July 2002-February 2010. The sensitivity of the screening methods was 36% for CBE, 73% for MX, 55% for US, and 100% for MRI; the specificity was 91%, 99%, 95%, and 80% for CBE, MX, US, and MRI, respectively. The annual BC detection rate was 2.9%. The median age at BC diagnosis was 33 years. Although age had no influence, menarche before as opposed to after radiation therapy correlated significantly with BC (P=.027): the annual BC detection rate in the former subgroup was 5.3%. Conclusions: Mammography proved more sensitive and specific in our cohort of young women than CBE or US. Magnetic resonance imaging proved 100% sensitive (but this preliminary finding needs to be confirmed). Our cohort of patients carries a 10-fold BC risk at an age more than 20 years younger than in the general population.

  18. Occurrence of Breast Cancer After Chest Wall Irradiation for Pediatric Cancer, as Detected by a Multimodal Screening Program

    International Nuclear Information System (INIS)

    Purpose: To assess the occurrence of breast cancer (BC) after exposure to ionizing radiation for pediatric cancer, by means of a multimodal screening program. Patients and Methods: We identified 86 patients who had received chest wall radiation therapy for pediatric cancer. Clinical breast examination (CBE), ultrasound (US), and mammography (MX) were performed yearly. Magnetic resonance imaging (MRI) was added as of October 2007. We calculated the risk of developing BC by radiation therapy dose, patient age, and menarche before or after primary treatment. Results: Eleven women developed a BC from July 2002-February 2010. The sensitivity of the screening methods was 36% for CBE, 73% for MX, 55% for US, and 100% for MRI; the specificity was 91%, 99%, 95%, and 80% for CBE, MX, US, and MRI, respectively. The annual BC detection rate was 2.9%. The median age at BC diagnosis was 33 years. Although age had no influence, menarche before as opposed to after radiation therapy correlated significantly with BC (P=.027): the annual BC detection rate in the former subgroup was 5.3%. Conclusions: Mammography proved more sensitive and specific in our cohort of young women than CBE or US. Magnetic resonance imaging proved 100% sensitive (but this preliminary finding needs to be confirmed). Our cohort of patients carries a 10-fold BC risk at an age more than 20 years younger than in the general population.

  19. Development of an effective valve packing program

    Energy Technology Data Exchange (ETDEWEB)

    Hart, K.A.

    1996-12-01

    Current data now shows that graphite valve packing installed within the guidance of a controlled program produces not only reliable stem sealing but predictable running loads. By utilizing recent technological developments in valve performance monitoring for both MOV`s and AOV`s, valve packing performance can be enhanced while reducing maintenance costs. Once known, values are established for acceptable valve packing loads, the measurement of actual valve running loads via the current MOV/AOV diagnostic techniques can provide indication of future valve stem sealing problems, improper valve packing installation or identify the opportunity for valve packing program improvements. At times the full benefit of these advances in material and predictive technology remain under utilized due to simple past misconceptions associated with valve packing. This paper will explore the basis for these misconceptions, provide general insight into the current understanding of valve packing and demonstrate how with this new understanding and current valve diagnostic equipment the key aspects required to develop an effective, quality valve packing program fit together. The cost and operational benefits provided by this approach can be significant impact by the: elimination of periodic valve repacking, reduction of maintenance costs, benefits of leak-free valve operation, justification for reduced Post Maintenance Test Requirements, reduced radiation exposure, improved plant appearance.

  20. Cancer developing among atom-bomb survivors

    International Nuclear Information System (INIS)

    Cancer (with the exception of leukemia) which had often been observed among atom bomb survivors was discussed. Prevalence of thyroid carcinoma was high in the people who had been exposed to more than 50 rad of the atomic radiation. A great difference in prevalence of cancer was seen between irradiated people whose age had been under 20 years at the time of exposure and non-irradiated. More women than men had papillary adenocarcinoma. The highest prevalence was seen 16 to 20 years after exposure to atomic radiation, but there was no difference in prevalence between those from Hiroshima and from Nagasaki. Lung cancer comprised 89% of all cancers of the people whose age was 50 years and over. Most of them had been exposed to atomic radiation of more than 300 rad. The type was cellular retrograde cancer. The prevalence of gastric carcinoma was low, and breast cancer occurred at an early age before menopause. The occurrence of cancer in juvenile survivors was several times higher in the patients who had been exposed to atomic radiation of more than 100 rad than in non-irradiated. These values indicate that cancer occurs more frequently than leukemia does in such survivors. (Kanao, N.)

  1. Developing solar power programs : San Francisco's experience

    International Nuclear Information System (INIS)

    This keynote address discussed an array of solar programs initiated in government-owned buildings in San Francisco. The programs were strongly supported by the city's mayor,and the voting public. Known for its fog and varying microclimates, 11 monitoring stations were set up throughout the city to determine viable locations for the successful application of solar technologies. It was observed that 90 per cent of the available sunshine occurred in the central valley, whereas fog along the Pacific shore was problematic. Seven of the monitoring sites showed excellent results. Relationships with various city departments were described, as well as details of study loads, load profiles, electrical systems, roofs and the structural capabilities of the selected government buildings. There was a focus on developing good relations with the local utility. The Moscone Convention Center was selected for the program's flagship installation, a 675 kW solar project which eventually won the US EPA Green Power Award for 2004 and received high press coverage. Cost of the project was $4.2 million. 825,000 kWh solar electricity was generated, along with 4,500,000 kWh electricity saved annually from efficiency measures, resulting in a net reduction of 5,325,000 kWh. Savings on utilities bills for the center were an estimated $1,078,000. A pipeline of solar projects followed, with installations at a sewage treatment plant and a large recycling depot. A program of smaller sites included libraries, schools and health facilities. Details of plans to apply solar technology to a 500 acre redevelopment site in southeast San Francisco with an aging and inadequate electrical infrastructure were described. A model of efficient solar housing for the development was presented, with details of insulation, windows, heating ventilation and air-conditioning (HVAC), water heating, lighting, appliances and a 1.2 kilowatt solar system. Peak demand reductions were also presented. tabs., figs

  2. A community-based cervical cancer screening program among women of Delhi using camp approach

    Directory of Open Access Journals (Sweden)

    Sharma Pragya

    2010-01-01

    Full Text Available Background: Cervical cancer is the commonest malignancy among women in developing countries. Cytological screening (Pap smear have been claimed to reduce incidence and mortality of carcinoma cervix significantly for which sensitization of women is required through community-based approach. Objectives: To find out number of cervical cancer cases among patients reporting to a general health care camp through screening program and study the prevalence of perceived morbidity and its confirmation. Settings: Cross-sectional study among women attending cancer awareness camps. Materials and Methods: A total of 435 women attending cancer awareness camps were screened for carcinoma cervix. The findings of history and clinical examination were recorded. Pap smears of all the symptomatic patients were collected and cytological diagnosis was confirmed by a pathologist. Results and Conclusions: The perceived gynecological morbidity was observed to be 59.8%. The smear of the women who were suspected of carcinoma on clinical examination was confirmed to be the cases of carcinoma-in-situ (7.8% and high-grade neoplasia (2.9% on laboratory investigations. The findings of the study highlight the utility and need of cancer cervix screening among the women at regular intervals through camp approach in the community.

  3. Efficacy and safety of oxaliplatin chemotherapy programs as adjuvant treatment in colorectal cancer after surgery

    Institute of Scientific and Technical Information of China (English)

    杨莉萍

    2013-01-01

    Objective To compare the efficacy and safety of 5-fluorouracil and calcium folinatc combined with oxaliplatin(FOLFOX) program with capecitabine regimen combined oxaliplatin(XELOX) program as adjuvant chemotherapy in advanced colorectal cancer after surgery.

  4. Design elements for the development of cancer education print materials for a Latina/o audience.

    Science.gov (United States)

    Buki, Lydia P; Salazar, Silvia I; Pitton, Viviana O

    2009-10-01

    Health educators can help reduce cancer disparities in Latino populations through the creation of effective print materials. In this effort, the National Cancer Institute conducted a comprehensive needs assessment to identify key design elements of cancer education programs and create a cost-effective process that would ensure consistency in the development of materials. This article introduces the Checklist of Design Elements for the Development of Cancer Education Print Materials for Latina/o Audiences (CEMLA), which includes a total of 10 design elements related to the process of developing materials and content. Using social learning theory as a theoretical framework, design elements are included that reflect cultural sensitivity at the surface and deep structure levels. This is the most comprehensive effort to date to integrate and synthesize theory and application in the design of materials for this audience. PMID:19098265

  5. Developing National Cancer Registration in Developing Countries- Case Study of the Nigerian National System of Cancer Registries

    Directory of Open Access Journals (Sweden)

    Elima E Jedy-Agba

    2015-07-01

    Full Text Available The epidemiologic transition in sub-Saharan Africa (SSA has given rise to a concomitant increase in the incidence of non-communicable diseases including cancers. Worldwide, cancer registries have been shown to be critical for the determination of cancer burden, conduct of research, and in the planning and implementation of cancer control measures. Cancer registration though vital is often neglected in SSA owing to competing demands for resources for healthcare.We report the implementation of a system for representative nation-wide cancer registration in Nigeria - the Nigerian National System of Cancer Registries (NSCR. The NSCR coordinates the activities of cancer registries in Nigeria, strengthens existing registries, establishes new registries, complies and analyses data, and makes these freely available to researchers and policy makers. We highlight the key challenges encountered in implementing this strategy and how they were overcome. This report serves as a guide for other low and middle income countries (LMIC wishing to expand cancer registration coverage in their countries and highlights the training, mentoring, scientific and logistic support, and advocacy that are crucial to sustaining cancer registration programs in LMIC

  6. Development of inpatient oncology educational and support programs.

    Science.gov (United States)

    Grassman, D

    1993-05-01

    Support programs are needed to help patients manage the overwhelming emotions they experience when diagnosed and treated for cancer. Although many cancer support groups exist, most programs are designed for outpatients. Support groups for hospitalized patients and their families are an excellent way to provide greatly needed education and support to those who otherwise might not be able or willing to attend outpatient programs. Inpatient programs also offer the opportunity to provide support to people at the onset of diagnosis and treatment--a time when these services are particularly needed. This paper describes special considerations regarding the establishment of inpatient educational and support programs. The evolution of the Oncology Health Management Program of the Bay Pines VA Medical Center in Bay Pines, FL, also is presented. This multidisciplinary program for inpatients includes classes in spiritual support, family support, patient support, symptom management, stress management, and laughter therapy. Evaluation of the program revealed that classes that related symptom management were most useful and that laughter therapy and emotional support were reported to be highly beneficial as well. Nursing staff also gained from their participation in leading the program and expressed greater self-awareness and self-esteem. This has resulted in improved job satisfaction and staff retention as well as in more sensitive and compassionate delivery of patient care. These findings show that providing inpatient educational and support programs is an effective means of meeting the physical, mental, emotional, and spiritual needs of patients with cancer and their families. PMID:7686668

  7. Opportunities for Cancer Prevention Using Employee Wellness Programs: The Case of Kansas State Employees

    Science.gov (United States)

    Hui, Siu-kuen Azor; Engelman, Kimberly; Shireman, Theresa I.; Hunt, Suzanne; Ellerbeck, Edward F.

    2012-01-01

    Background: The utility of employee wellness programs (EWPs) in cancer prevention and control is not well established. Purpose: This project is to determine the potential value of EWPs in preventing cancer by examining the characteristics of EWP participants and their prevalence of cancer risk factors. Methods: A secondary data analysis of health…

  8. Standard Review Plan Update and Development Program

    Energy Technology Data Exchange (ETDEWEB)

    1992-05-01

    This implementing procedures document (IPD) was prepared for use in implementing tasks under the standard review plan update and development program (SRP-UDP). The IPD provides comprehensive guidance and detailed procedures for SRP-UDP tasks. The IPD is mandatory for contractors performing work for the SRP-UDP. It is guidance for the staff. At the completion of the SRP-UDP, the IPD will be revised (to remove the UDP aspects) and will replace NRR Office Letter No. 800 as long-term maintenance procedures.

  9. Oracle PLSQL Programming A Developer's Workbook

    CERN Document Server

    Feuerstein, Steven

    2008-01-01

    However excellent they are, most computer books are inherently passive--readers simply take in text without having any opportunity to react to it. The Oracle PL/SQL Developer's Workbook is a different kind of animal! It's designed to engage you actively, to get you solving programming problems immediately, and to help you apply what you've learned about PL/SQL--and in the process deepen your knowledge of the language. By tackling the exercises in this workbook, you'll find yourself moving more rapidly along the learning curve to join the growing ranks of PL/SQL experts. The Oracle PL/SQL

  10. Duplex tube steam reformer development program

    International Nuclear Information System (INIS)

    Work done in partial fulfillment of Task 7 of the Duplex Steam Reformer Development Program is described. The DSR concept acts as a double barrier between a process heat high temperature reactor plant (PNP) and a closed loop chemical heat pipe (CHP) for the long distance transport of chemical energy to a remote industrial user. The current state of the DSR design is described as well as related systems and equipment. The PNP concept presented is based upon work currently underway in the Federal Republic of Germany

  11. Standard Review Plan Update and Development Program

    International Nuclear Information System (INIS)

    This implementing procedures document (IPD) was prepared for use in implementing tasks under the standard review plan update and development program (SRP-UDP). The IPD provides comprehensive guidance and detailed procedures for SRP-UDP tasks. The IPD is mandatory for contractors performing work for the SRP-UDP. It is guidance for the staff. At the completion of the SRP-UDP, the IPD will be revised (to remove the UDP aspects) and will replace NRR Office Letter No. 800 as long-term maintenance procedures

  12. Programming language concepts for software developers

    DEFF Research Database (Denmark)

    Sestoft, Peter

    2008-01-01

    This note describes and motivates our current plans for an undergraduate course on programming language concepts for software development students. We describe the competences we expect students to acquire as well as the topics covered by the course. We plan to use C# and Scheme as instruction...... languages, and will study the implementation of Java and C# with their underlying platforms, the Java Virtual Machine and .NET Common Language Runtime. We emphasize implementation exercises and experiments. This comes at the expense of classical compiler course subjects such as register allocation...

  13. Simulation of reduced breast cancer mortality in breast cancer screening programs; Simulacion de la reduccion de mortalidad por cancer de mama en programas de cribado mamografico

    Energy Technology Data Exchange (ETDEWEB)

    Zamora, L. I.; Forastero, C.; Guirado, D.; Lallena, A. M.

    2011-07-01

    The breast cancer screening programs are an essential tool in the fight against breast cancer. Currently, many questions concerning the setup of these programs are open, namely: age range of women who undergo the same, frequency of mammography, ... The effectiveness of a program should be evaluated in terms of mortality reduction is its systematic implementation in the population. In this sense, we performed Monte Carlo simulations to assess that these reductions.

  14. Mixed Waste Integrated Program emerging technology development

    International Nuclear Information System (INIS)

    The US Department of Energy (DOE) is responsible for the management and treatment of its mixed low-level wastes (MLLW). MLLW are regulated under both the Resource Conservation and Recovery Act and various DOE orders. Over the next 5 years, DOE will manage over 1.2 m3 of MLLW and mixed transuranic (MTRU) wastes. In order to successfully manage and treat these mixed wastes, DOE must adapt and develop characterization, treatment, and disposal technologies which will meet performance criteria, regulatory approvals, and public acceptance. Although technology to treat MLLW is not currently available without modification, DOE is committed to developing such treatment technologies and demonstrating them at the field scale by FY 1997. The Office of Research and Development's Mixed Waste Integrated Program (MWIP) within the DOE Office of Environmental Management (EM), OfFice of Technology Development, is responsible for the development and demonstration of such technologies for MLLW and MTRU wastes. MWIP advocates and sponsors expedited technology development and demonstrations for the treatment of MLLW

  15. Nutrients Impact the Pathogenesis and Development of Colorectal Cancer

    Science.gov (United States)

    Du, Wan; Fang, Jing-Yuan

    2016-01-01

    Background Colorectal cancer is a commonly diagnosed cancer and the cause of many cancer deaths worldwide. Nutrients might be crucial in the pathogenesis and development of colorectal cancer. Although a number of studies have demonstrated the potential effects of nutrients, many challenges still remain Summary A tremendous amount of research has emerged concerning the roles of nutrients in colorectal cancer during the past decades. Here, we review the latest research progress on nutrients, including vitamins, folic acid, calcium, selenium and dietary fiber, involved in colorectal cancer prevention Key Message Nutrients are commonly consumed in foods or dietary supplements. It is clear that nutrients could play an important role and influence colorectal cancer outcomes. The relationship between nutrients and colorectal risk is complex. Vitamins, folic acid, calcium, selenium and dietary fiber have been proposed as potential agents to prevent colorectal cancer. However, some studies found that these nutrients did not reduce the incidence of colorectal cancer Practical Implications The supplementary dose of nutrients, the length of time required to observe the effects and confounding factors during the study might influence the role of nutrients in the prevention of colorectal cancer. Therefore, more evidence from ongoing clinical trials with different population groups and longer follow-up periods is critical to determine the relationship between nutrients and colorectal cancer. PMID:27403415

  16. Left behind: cancer disparities in the developed world.

    Science.gov (United States)

    Dixit, Niharika; Crawford, Gregory B; Lemonde, Manon; Rittenberg, Cynthia N; Fernández-Ortega, Paz

    2016-08-01

    Huge advances have been made in cancer treatments over recent decades; however, significant disparities still exist in the developed world on the basis of race, socioeconomic status, education level, geographical location, and immigration status and in the United States, insurance status. Cancer disparities persist in the continuum of cancer care from risk factors, screening, diagnosis, treatment, survivorship, and end-of-life care. The causes of disparities are complex and multifactorial. The MASCC (Multinational Association of Supportive Care in Cancer) Education Study Group would like to propose a framework of cancer disparities from a social perspective utilizing "social determinants of health" as delineated by the World Health Organization and highlight an unmet need for research and policy innovations to address cancer disparities in developed world. PMID:27052305

  17. Developing a Culturally Responsive Breast Cancer Screening Promotion with Native Hawaiian Women in Churches

    Science.gov (United States)

    Kaopua, Lana Sue

    2008-01-01

    This article presents findings from research to develop the promotional component of a breast cancer screening program for Native Hawaiian women associated with historically Hawaiian churches in medically underserved communities. The literature on adherence to health recommendations and health promotions marketing guided inquiry on screening…

  18. Thyroid stem cells: lessons from normal development and thyroid cancer

    OpenAIRE

    Thomas, Dolly; Friedman, Susan; Lin, Reigh-Yi

    2008-01-01

    Ongoing advances in stem cell research have opened new avenues for therapy for many human disorders. Until recently, however, thyroid stem cells have been relatively understudied. Here, we review what is known about thyroid stem cells and explore their utility as models of normal and malignant biological development. We also discuss the cellular origin of thyroid cancer stem cells and explore the clinical implications of cancer stem cells in the thyroid gland. Since thyroid cancer is the most...

  19. Developing imaging strategies for castration resistant prostate cancer

    International Nuclear Information System (INIS)

    Recent advances in the understanding of castrate-resistant prostate cancer (CRPC) have lead to a growing number of experimental therapies, many of which are directed against the androgen-receptor (AR) signaling axis. These advances generate the need for reliable molecular imaging biomarkers to non-invasively determine efficacy, and to better guide treatment selection of these promising AR-targeted drugs. Methods. We draw on our own experience, supplemented by review of the current literature, to discuss the systematic development of imaging biomarkers for use in the context of CRPC, with a focus on bone scintigraphy, F-18 fluorodeoxyglucose (FDG)-positron emission tomography (PET) and PET imaging of the AR signaling axis. Results. The roadmap to biomarker development mandates rigorous standardization and analytic validation of an assay before it can be qualified successfully for use in an appropriate clinical context. The Prostate Cancer Working Group 2 (PCWG2) criteria for 'radiographic' progression by bone scintigraphy serve as a paradigm of this process. Implemented by the Prostate Cancer Clinical Trials Consortium (PCCTC), these consensus criteria may ultimately enable the co-development of more potent and versatile molecular imaging biomarkers. Purported to be superior to single-photon bone scanning, the added value of Na18F-PET for imaging of bone metastases is still uncertain. FDG-PET already plays an integral role in the management of many diseases, but requires further evaluation before being qualified in the context of CRPC. PET tracers that probe the AR signaling axis, such as 18F-FDHT and 89Zr-591, are now under development as pharmacodynamic markers, and as markers of efficacy, in tandem with FDG-PET. Semi-automated analysis programs for facilitating PET interpretation may serve as a valuable tool to help navigate the biomarker roadmap. Conclusions. Molecular imaging strategies, particularly those that probe the AR signaling axis, have the potential to

  20. Life time risk for development of ten major cancers in India and its trends over the years 1982 to 2000

    Directory of Open Access Journals (Sweden)

    Satyanarayana L

    2008-02-01

    Full Text Available Background : Understanding cancer magnitude, risk and trends will be of help in cancer control programs. Aim : To study trends in cumulative risk up to 64 years of age as lifetime risk of developing major cancers in India during the years 1982 to 2000. Design : Retrospective. Setting : Secondary sources of cancer-registration data. Materials and Methods : Data on age-specific cancer-incidence rates were collected for patients 0-64 years of age of either sex for 10 major cancer sites from the National Cancer Registry Program (NCRP reports of India from Mumbai, Chennai, Bangalore, Bhopal and Delhi; and Barshi registries for the years 1982 or 1988 to 2000. Statistical Analysis : Cumulative risks computed for lifetime development of cancer. Linear trends were studied using simple linear regressions. Results : The lifetime risk among females for the10 cancer sites ranged from 0.02 to 3.3% and from 0.04 to 2.4% for the years 1982 and 2000 respectively; whereas among males, it ranged from 0.04 to 0.89% and from 0.05 to 0.95% respectively. Significant (P < 0.05 increasing trends were observed for breast, non-Hodgkin′s lymphoma (NHL, gallbladder, thyroid and ovary cancers among females; while declining trends were observed for cervix, mouth, stomach, esophagus and tongue cancers. Among males, significant (P < 0.05 increasing trends were observed for NHL and prostate cancer; whereas declining trends were observed for stomach, liver, hypopharynx and tongue cancers. Cancers of mouth and esophagus showed increasing trends (P < 0.05 in some regions and declining trends (P < 0.05 in some other. Conclusion : Significant and higher rates of positive trends in lifetime cancer risks for breast cancer among females and for NHL among both sexes were observed.

  1. FISH CANCER DEVELOPED BY ENVIRONMENTAL POLLUTANTS

    Directory of Open Access Journals (Sweden)

    Madhuri S.

    2012-10-01

    Full Text Available The pollution of rivers and streams with chemical contaminants has become one of the most critical environmental problems. Fish living in a polluted water reservoir use the contaminated water to rinse their gills; this results in the deposition of polycyclic aromatic hydrocarbons (PAHs in the fish body. Contamination of foodstuffs by heavy metals such as arsenic, cadmium, chromium, nickel and lead has poses a potential carcinogenic threat to humans. Arsenic and cadmium appear to be the most harmful to the fish. Several cancers in fish appear to be the result of exposure to different environmental pollutants/chemicals. High frequencies of liver and skin cancers in brown bullheads are associated with high concentrations of PAHs and some metals in the environmental sediments. Taking these facts in view, the present article gives the emphasis on the fish cancer caused by various environmental pollutants, suggesting that fish species are truly suffer from different cancers/tumours.

  2. The low-enrichment fuel development program

    International Nuclear Information System (INIS)

    In the 1950s and 1960s, low-power research reactors were built around the world utilized MTR-type fuel elements containing 20% enriched uranium. However, the demand for higher specific power created a need for greater uranium-235 concentrations. Early difficulties in increasing uranium content led to the substitution of highly enriched uranium in place of the 20% enriched fuel previously utilized. The highly enriched material also yielded other benefits including longer core residence time, higher specific reactivity, and somewhat lower cost. Highly enriched material then became readily available and was used for high-power reactors as well as in low-power reactors where 20% enriched material would have sufficed. The trend toward higher and higher specific power also led to the development of the dispersion-type fuels which utilized highly enriched uranium at a concentration of about 40 wt%. In the 1970's, however, concerns were raised about the proliferation resistance of fuels and fuel cycles. As a consequence, the U.S. Department of State has recently prohibited the foreign shipment of highly enriched material, except where prior contractual obligation or special merit exists. This will impact on the availability and utilization of highly enriched uranium for research and test reactor fuel. It has also stimulated development programs on fuels with higher uranium content which would allow the use of uranium of lower enrichment. The purpose of this report is to briefly describe the overall fuel development program which is coordinated by Argonne National Laboratory for the Department of Energy, and to indicate the current and potential uranium loadings. Other reports will address the individual fuel-development activities in greater detail

  3. The low-enrichment fuel development program

    International Nuclear Information System (INIS)

    In the 1950s and 1960s, low-power research reactors were built around the world utilized MTR-type fuel elements containing 20% enriched uranium. However, the demand for higher specific power created a need for greater uranium-235 concentrations. Early difficulties in increasing uranium content led to the substitution of highly enriched uranium in place of the 20% enriched fuel previously utilized. The highly enriched material also yielded other benefits including longer core residence time, higher specific reactivity, and somewhat lower cost. Highly enriched material then became readily available and was used for high-power reactors as well as in low-power reactors where 20% enriched material would have sufficed. The trend toward higher and higher specific power also led to the development of the dispersion-type fuels which utilized highly enriched uranium at a concentration of about 40 wt%. In the 1970's, however, concerns were raised about the proliferation resistance of fuels and fuel cycles. As a consequence, the U.S. Department of State has recently prohibited the foreign shipment of highly enriched material, except where prior contractual obligation or special merit exists. This will impact on the availability and utilization of highly enriched uranium for research and test reactor fuel. It has also stimulated development programs on fuels with higher uranium content which would allow the use of uranium of lower enrichment. The purpose of this report is to briefly describe the overall fuel-development program which is coordinated by Argonne National Laboratory for the Department of Energy, and to indicate the current and potential uranium loadings. Other reports will address the individual fuel-development activities in greater detail

  4. The National Cancer Informatics Program (NCIP) Annotation and Image Markup (AIM) Foundation Model

    OpenAIRE

    Mongkolwat, Pattanasak; Kleper, Vladimir; Talbot, Skip; Rubin, Daniel

    2014-01-01

    Knowledge contained within in vivo imaging annotated by human experts or computer programs is typically stored as unstructured text and separated from other associated information. The National Cancer Informatics Program (NCIP) Annotation and Image Markup (AIM) Foundation information model is an evolution of the National Institute of Health’s (NIH) National Cancer Institute’s (NCI) Cancer Bioinformatics Grid (caBIG®) AIM model. The model applies to various image types created by various techn...

  5. Introducing Students to Cancer Prevention Careers through Programmed Summer Research Experiences

    OpenAIRE

    Cameron, Carrie; Collie, Candice L.; Chang, Shine

    2012-01-01

    Training programs in cancer prevention research play an important role in addressing impending shortages in the cancer prevention workforce. Published reports on the effectiveness of these programs, however, often focus on a program’s success in recruiting and retaining a demographically diverse trainee population or on academic successes of the trainees, in general. Little has been reported about programs’ success in stimulating long-term interest in cancer prevention per se, whether in rese...

  6. Employer-Based Disease Management Programs in Cancer: Experience to Date

    OpenAIRE

    Frederick C. Lee

    2004-01-01

    The cancer disease management field took root in the early 1990s. Health plans in the US seeking to aggressively manage cancer reached out to entrepreneurial start-ups that had infused the general principles of managed care into cancer programs. More than two dozen health plans had adopted some form of cancer disease management by the end of the century. However, employers, witnessing the managed care backlash and experiencing difficulty recruiting an adequate pool of skilled labor during flu...

  7. The first national public breast cancer screening program in Saudi Arabia

    OpenAIRE

    Abulkhair, Omalkhair A.; Al Tahan, Fatina M.; Young, Susan E.; Musaad, Salma MA.; Jazieh, Abdul-Rahman M.

    2010-01-01

    BACKGROUND AND OBJECTIVES: Despite its relatively low incidence in Saudi Arabia, breast cancer has been the most common cancer among Saudi females for the past 12 consecutive years. The objective of this study was to report the results of the first national public breast cancer screening program in Saudi Arabia. METHODS: Women 40 years of age or older underwent breast cancer screening. Mammograms were scored using the Breast Imaging-Reporting and Data System (BI-RADS). Correlations between im...

  8. Polymer OLED White Light Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Homer Antoniadis; Vi-En Choong; Stelios Choulis; Brian Cumpston; Rahul Gupta; Mathew Mathai; Michael Moyer; Franky So

    2005-12-19

    OSRAM Opto Semiconductors (OSRAM) successfully completed development, fabrication and characterization of the large area, polymer based white light OLED prototype at their OLED Research and Development (R&D) facility in San Jose, CA. The program, funded by the Department of Energy (DOE), consisted of three key objectives: (1) Develop new polymer materials and device architectures--in order to improve the performance of organic light emitters. (2) Develop processing techniques--in order to demonstrate and enable the manufacturing of large area, white light and color tunable, solid state light sources. (3) Develop new electronics and driving schemes for organic light sources, including color-tunable light sources. The key performance goals are listed. A world record efficiency of 25 lm/W was established for the solution processed white organic device from the significant improvements made during the project. However, the challenges to transfer this technology from an R&D level to a large tile format such as, the robustness of the device and the coating uniformity of large area panels, remain. In this regard, the purity and the blend nature of the materials are two factors that need to be addressed in future work. During the first year, OSRAM's Materials and Device group (M&D) worked closely with the major polymer material suppliers to develop the polymer emissive technology. M&D was successful in demonstrating a 7-8 lm/W white light source which was based on fluorescent materials. However, it became apparent that the major gains in efficiency could only be made if phosphorescent materials were utilized. Thus, in order to improve the performance of the resulting devices, the focus of the project shifted towards development of solution-processable phosphorescent light emitting diodes (PHOLEDs) and device architectures. The result is a higher efficiency than the outlined project milestone.

  9. Communication and community development: early child development programs.

    Science.gov (United States)

    Wood, F; Reinhold, A J

    1993-01-01

    Community-based groups are organized around particular aspects of early childhood development (ECD), such as literacy, parent education, and early childhood activities. In the Colombian national program, community households call upon women to devote a portion of their home to organized child care for minimal material reward. The Indian Child Development Service subsidizes the payment of organizers; and Kenyan parents construct basic preschool facilities, provide school lunches, and subsidize a teacher. In such cases the government plays a subordinate role, while the burden of program maintenance is carried by the community. These programs share the characteristics that children and adults learn side by side; adult learning ranges from women's literacy, to health, organizational issues, or small-scale economic development; a strong cultural component emphasizes mother tongue language learning, indigenous child-rearing practices, and local working models; physical structures are in homes; capacity-building for the adults is central which will be transferred to other spheres of community life. In the remote coastal villages of Colombia, an organization called Promesa works with mothers on designing their preschool children's educational activities. Promesa began to confront other priority needs in the villages, especially in environmental health and malaria control. A 1990 assessment related that participants' pride, self-confidence, and ability to solve problems regarding the healthy development of their children increased; groups learned to make use of the physical, human, and institutional resources from their environments; and participants' children remained in school and performed better. Conclusions from a decade of loose experimentation suggest that through communication community women can be organized to provide basic early education and early childhood activities can help rural children over the cultural barrier of school. PMID:12317893

  10. Building Technologies Program Multi-Year Program Plan Research and Development 2008

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2008-01-01

    Building Technologies Program Multi-Year Program Plan 2008 for research and development, including residential and commercial integration, lighting, HVAC and water heating, envelope, windows, and analysis tools.

  11. Evaluation of Project Students are Sun Safe (SASS): A University Student-Delivered Skin Cancer Prevention Program for Schools.

    Science.gov (United States)

    Davis, Raeann; Loescher, Lois J; Rogers, Jillian; Spartonos, Denise; Snyder, Aimee; Koch, Stephanie; Harris, Robin B

    2015-12-01

    Skin cancer is the most common cancer in the USA and is increasing in children and young adults. Adolescents are an important target population for sun-safety interventions with ultraviolet radiation as the strongest risk factor for developing skin cancer. Schools are an ideal setting to intervene with adolescents. A novel Arizona skin cancer prevention in-class education-activity program, Project 'Students are Sun Safe' (SASS), was designed to be delivered by university students for middle school and high school students. Participant students completed the pre- and post-program tests and a satisfaction questionnaire; teachers completed reviews. The evaluation examined the program's influence on participants' sun-safety knowledge, perceptions, and behaviors; satisfaction with the program; and intent to change. After exposure to Project SASS, participants were more likely to perceive a high risk of skin cancer, report negative attitudes toward tanned skin, and answer knowledge-based questions correctly. There were minimal differences in self-reported sun-safety behaviors, though participants did report intent to change. Both participants and teachers were satisfied with the program. Project SASS appears to be an effective sun-safety program for middle school and high school students for knowledge and perceptions, and the results confirm that appropriately tailoring program components to the target population has strong potential to impact adolescent perceived susceptibility, knowledge, and behavioral intent. The strengths and weaknesses of Project SASS have many implications for public health practice, and Project SASS may hold promise to be a model for skin cancer prevention in adolescents. PMID:25417824

  12. CANCER

    Directory of Open Access Journals (Sweden)

    N. Kavoussi

    1973-09-01

    Full Text Available There are many carcinogenetic elements in industry and it is for this reason that study and research concerning the effect of these materials is carried out on a national and international level. The establishment and growth of cancer are affected by different factors in two main areas:-1 The nature of the human or animal including sex, age, point and method of entry, fat metabolism, place of agglomeration of carcinogenetic material, amount of material absorbed by the body and the immunity of the body.2 The different nature of the carcinogenetic material e.g. physical, chemical quality, degree of solvency in fat and purity of impurity of the element. As the development of cancer is dependent upon so many factors, it is extremely difficult to determine whether a causative element is principle or contributory. Some materials are not carcinogenetic when they are pure but become so when they combine with other elements. All of this creates an industrial health problem in that it is almost impossible to plan an adequate prevention and safety program. The body through its system of immunity protects itself against small amounts of carcinogens but when this amount increases and reaches a certain level the body is not longer able to defend itself. ILO advises an effective protection campaign against cancer based on the Well –equipped laboratories, Well-educated personnel, the establishment of industrial hygiene within factories, the regular control of safety systems, and the implementation of industrial health principles and research programs.

  13. Substantial contribution of extrinsic risk factors to cancer development | Office of Cancer Genomics

    Science.gov (United States)

    Recent research has highlighted a strong correlation between tissue-specific cancer risk and the lifetime number of tissue-specific stem-cell divisions. Whether such correlation implies a high unavoidable intrinsic cancer risk has become a key public health debate with the dissemination of the 'bad luck' hypothesis. Here we provide evidence that intrinsic risk factors contribute only modestly (less than ~10-30% of lifetime risk) to cancer development.

  14. Laboratory Directed Research and Development Program FY 2008 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    editor, Todd C Hansen

    2009-02-23

    consideration and review by the Office of Science Program Offices, such as LDRD projects germane to new research facility concepts and new fundamental science directions. Berkeley Lab LDRD program also play an important role in leveraging DOE capabilities for national needs. The fundamental scientific research and development conducted in the program advances the skills and technologies of importance to our Work For Others (WFO) sponsors. Among many directions, these include a broad range of health-related science and technology of interest to the National Institutes of Health, breast cancer and accelerator research supported by the Department of Defense, detector technologies that should be useful to the Department of Homeland Security, and particle detection that will be valuable to the Environmental Protection Agency. The Berkeley Lab Laboratory Directed Research and Development Program FY2008 report is compiled from annual reports submitted by principal investigators following the close of the fiscal year. This report describes the supported projects and summarizes their accomplishments. It constitutes a part of the LDRD program planning and documentation process that includes an annual planning cycle, project selection, implementation, and review.

  15. Laboratory Directed Research and Development Program FY 2008 Annual Report

    International Nuclear Information System (INIS)

    Office of Science Program Offices, such as LDRD projects germane to new research facility concepts and new fundamental science directions. Berkeley Lab LDRD program also play an important role in leveraging DOE capabilities for national needs. The fundamental scientific research and development conducted in the program advances the skills and technologies of importance to our Work For Others (WFO) sponsors. Among many directions, these include a broad range of health-related science and technology of interest to the National Institutes of Health, breast cancer and accelerator research supported by the Department of Defense, detector technologies that should be useful to the Department of Homeland Security, and particle detection that will be valuable to the Environmental Protection Agency. The Berkeley Lab Laboratory Directed Research and Development Program FY2008 report is compiled from annual reports submitted by principal investigators following the close of the fiscal year. This report describes the supported projects and summarizes their accomplishments. It constitutes a part of the LDRD program planning and documentation process that includes an annual planning cycle, project selection, implementation, and review

  16. Development of BASIC program for radiocarbon dating

    International Nuclear Information System (INIS)

    The continuous improvement of the system and the needs have produced the successful radiocarbon dating system of today to detect very low energy β-radioactivity. However, it still takes longer than 1,000 minutes for a sample counting. In a gas counting system, it is very difficult to keep the drift of impressed high voltage for a proportional counter less than 5 volts throughout the counting time. The temperature and the characteristics of gas itself also change during experiment. The accumulation of the above drift and errors are closely concerned with the accuracy and reliability of the radiocarbon date. The detection and reduction of the errors are only possible by using a ''fully automatic radiocarbon dating system'' linked to a personal computer system. In this paper, the author presents the BASIC (Beginners All-purpose Symbolic Instruction Code) program for a fully automatic radiocarbon dating system. In this paper, the outline of the system and software development are described. The details of the program include the description for gas-collection, gas-enclosing, plateau counting, β-ray counting, age calculation and data file maintenance. The author wrote numerous remark statements into the program so that it can be understood by users without detailed knowledge of the operation of a personal computer system or of the radiocarbon dating. Using this system, the author found that the radiocarbon dating has greatly progressed in speed and labour-saving, and that the accuracy and reliability of the date itself has also improved much than former manual systems. (Wakatsuki, Y.)

  17. Taking Stock of Programs to Develop Socioemotional Skills

    OpenAIRE

    Sánchez Puerta, Maria Laura; Valerio, Alexandria; Gutiérrez Bernal, Marcela

    2016-01-01

    This book represents a systematic review of the documented impacts of programs aimed at fostering socio-emotional skills in developed and developing countries. It uses a life-cycle approach to organize the findings from rigorous evaluations of more than 80 programs. This includes programs for toddlers and young children before primary school, programs for students enrolled in formal education, and programs targeted at the out-of-school population. The book develops a conceptual framework tha...

  18. Development of cancer-targeting radionanoparticles

    International Nuclear Information System (INIS)

    Here we report the first formulation of porphyrin coated albumin nanoparticles that are coated by porphyrin which is known to be cancer-tropic agent and used for photodynamic therapy for the cancer. Albumin nanoparticles were prepared by solvent extraction method. Mean particle size of the prepares nanoparticles was dependent on the addition rate of ethanol and ranged from 100 to 200 nm. Hematoporphyrin IX dihydrochloride (HP) were chosen for surface modification of albumin nanoparticle. The amino residue of surface albumin nanoparticles (ep, from lysine) was linked with carboxyl group of HP. HP coated albumin nanoparticles were purified by ultracentrifugation and characterized by modulated differential calorimetry (MDSC), x-ray diffractometry, field-emission scanning electron microsope (FE-SEM), transmission electron microsopope (TEM). HP modified albumin nanoparticles showed a good chelation efficiency (more that 95 %) against 99mTc, being applicable to cancer targeting radio-nanoparticles. The uptake of HP modified albumin nanoparticles in CT-26 and A549 cancer cell line was greater than that of normal albumin anaopraticles, proving that HP modified albumin nanoparticles is valuable for the cancer targeting radio isotope nanoparticles

  19. Development of cancer-targeting radionanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Sim, C. G.; Yang, S. G.; Jin, H. E. [Seoul National University, Seoul (Korea, Republic of)

    2007-06-15

    Here we report the first formulation of porphyrin coated albumin nanoparticles that are coated by porphyrin which is known to be cancer-tropic agent and used for photodynamic therapy for the cancer. Albumin nanoparticles were prepared by solvent extraction method. Mean particle size of the prepares nanoparticles was dependent on the addition rate of ethanol and ranged from 100 to 200 nm. Hematoporphyrin IX dihydrochloride (HP) were chosen for surface modification of albumin nanoparticle. The amino residue of surface albumin nanoparticles (ep, from lysine) was linked with carboxyl group of HP. HP coated albumin nanoparticles were purified by ultracentrifugation and characterized by modulated differential calorimetry (MDSC), x-ray diffractometry, field-emission scanning electron microsope (FE-SEM), transmission electron microsopope (TEM). HP modified albumin nanoparticles showed a good chelation efficiency (more that 95 %) against {sup 99m}Tc, being applicable to cancer targeting radio-nanoparticles. The uptake of HP modified albumin nanoparticles in CT-26 and A549 cancer cell line was greater than that of normal albumin anaopraticles, proving that HP modified albumin nanoparticles is valuable for the cancer targeting radio isotope nanoparticles.

  20. GSG-GIS development program plan

    International Nuclear Information System (INIS)

    For the past 40 years, the Savannah River Site (SRS) has been subjected to numerous geological and geotechnical investigations in support of facility construction and waste site development and remediation. Over this period,.a variety of different subcontractors have collected large quantities of geoscience data. In addition, current programs involve numerous investigators from different departments, and consequently, earth science data and interpretations are scattered among the departments, investigators, and subcontractors at SRS. As a result, scientific and management decisions cannot take advantage of the significant body of information that exists at SRS. Recent DOE Orders (Systematic Evaluation Program, 1991) have put specific requirements on their contractors to compile geological databases to coordinate DOE site data gathering and interpretations, and to assist in compiling safety analysis reports. The Earth Science Advisory Committee and the Environmental Advisory Committee have also made specific recommendations on the management of SRS geoscience data. This plan describes a management system to identify, communicate, and compile SRS geological (including geohydrologic), seismological, and geotechnical (656) data and interpretations on a Geographic Information System (GIS)

  1. Population prevalence of hereditary breast cancer phenotypes and implementation of a genetic cancer risk assessment program in southern Brazil

    Directory of Open Access Journals (Sweden)

    Edenir I. Palmero

    2009-01-01

    Full Text Available In 2004, a population-based cohort (the Núcleo Mama Porto Alegre - NMPOA Cohort was started in Porto Alegre, southern Brazil and within that cohort, a hereditary breast cancer study was initiated, aiming to determine the prevalence of hereditary breast cancer phenotypes and evaluate acceptance of a genetic cancer risk assessment (GCRA program. Women from that cohort who reported a positive family history of cancer were referred to GCRA. Of the 9218 women enrolled, 1286 (13.9% reported a family history of cancer. Of the 902 women who attended GCRA, 55 (8% had an estimated lifetime risk of breast cancer ³ 20% and 214 (23.7% had pedigrees suggestive of a breast cancer predisposition syndrome; an unexpectedly high number of these fulfilled criteria for Li-Fraumeni-like syndrome (122 families, 66.7%. The overall prevalence of a hereditary breast cancer phenotype was 6.2% (95%CI: 5.67-6.65. These findings identified a problem of significant magnitude in the region and indicate that genetic cancer risk evaluation should be undertaken in a considerable proportion of the women from this community. The large proportion of women who attended GCRA (72.3% indicates that the program was well-accepted by the community, regardless of the potential cultural, economic and social barriers.

  2. DOE EM industry programs robotics development

    International Nuclear Information System (INIS)

    The Office of Science and Technology (OST) manages an aggressive program for RD and D, as well as testing and evaluation for the Department of Energy's (DOE's) Environmental Management (EM) organization. The goal is to develop new and improved environmental restoration and waste management technologies to clean up the inventory of the DOE weapons complex faster, safer, and cheaper than is possible with currently available technologies. Robotic systems reduce worker exposure to the absolute minimum, while providing proven, cost-effective, and, for some applications, the only acceptable technique for addressing challenging problems. Development of robotic systems for remote operations occurs in three main categories: tank waste characterization and retrieval; decontamination and dismantlement; and characterization, mapping, and inspection systems. In addition, the Federal Energy Technology Center (FETC) has some other projects which fall under the heading of supporting R and D. The central objective of all FETC robotic projects is to make robotic systems more attractive by reducing costs and health risks associated with the deployment of robotic technologies in the cleanup of the nuclear weapons complex. This will be accomplished through development of robots that are cheaper, faster, safer, and more reliable, as well as more straightforward to modify/adapt and more intuitive to operate with autonomous capabilities and intelligent controls that prevent accidents and optimize task execution

  3. Oncogenic KRAS activates an embryonic stem cell-like program in human colon cancer initiation

    OpenAIRE

    Le Rolle, Anne-France; Chiu, Thang K.; Zeng, Zhaoshi; Shia, Jinru; Weiser, Martin R; Paty, Philip B.; Chiu, Vi K

    2016-01-01

    Colorectal cancer is the third most frequently diagnosed cancer worldwide. Prevention of colorectal cancer initiation represents the most effective overall strategy to reduce its associated morbidity and mortality. Activating KRAS mutation (KRASmut ) is the most prevalent oncogenic driver in colorectal cancer development, and KRASmut inhibition represents an unmet clinical need. We apply a systems-level approach to study the impact of KRASmut on stem cell signaling during human colon cancer i...

  4. Effectiveness of an Ongoing, Community-Based Breast Cancer Prevention Program for Korean American Women.

    Science.gov (United States)

    Koh, Eun; Choi, Ga-Young; Cho, Ji Young

    2016-02-01

    The study evaluates the effectiveness of an ongoing, community-based breast cancer prevention program offered by a local social services agency in the Washington, DC, metropolitan area. Korean American women who participated in this breast cancer prevention program were compared with those who did not participate in their knowledge, attitude, and screening behaviors. The study found that the intervention group was more knowledgeable on breast cancer and related services and reported more positive attitudes toward breast cancer screening services than the comparison group. The participants in the intervention group were also more likely to plan to receive a mammogram than those in the comparison group. However, significant differences were not observed in the two groups in their intention to receive a clinical breast examination. The study findings suggest that an ongoing, community-based breast cancer prevention program can be an effective method of addressing breast cancer prevention disparities observed among Korean American women. PMID:26946886

  5. [Cost-effectiveness of an organized breast cancer screening program in Southern Brazil].

    Science.gov (United States)

    Ribeiro, Rodrigo Antonini; Caleffi, Maira; Polanczyk, Carisi Anne

    2013-11-01

    The aim of this study was to evaluate the cost-effectiveness of an organized breast cancer mammographic screening program implemented in Porto Alegre (Núcleo Mama Porto Alegre - NMPOA), Rio Grande do Sul State, Brazil. A Markov model was constructed to estimate the incremental cost-effectiveness ratio of NMPOA compared to current BC diagnosis and care in the Brazilian public health system, in a hypothetical cohort of women aged 40-69 years at risk of developing breast cancer. Model parameters were collected from NMPOA and the national literature. In the NMPOA strategy, effectiveness was modeled taking into account the actual observed screening adherence. Effectiveness was measured in quality-adjusted life years (QALYs). Incremental cost-effectiveness ratio in the base case was R$ 13,426 per QALY. This result was not sensitive to variation in the main model parameters in sensitivity analyses. Considering the threshold usually suggested as highly attractive in Brazil, breast cancer screening as performed in NMPOA is cost-effective in cities with high incidence of breast cancer. PMID:25402242

  6. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Standards News Cancer Cancer Programs Cancer Programs American Joint Committee on Cancer Cancer Advocacy Efforts Cancer Liaison ... Validation Programs Accredited Education Institutes CME Accreditation CME Joint Providership Program Program for Validation and Verification of ...

  7. Development of computer aided diagnosis for lung cancer CT screening

    International Nuclear Information System (INIS)

    The introduction of low dose lung cancer helical CT screening to the clinical site has been the fundamental basis of research on Computer Aided Diagnosis (CAD) using thoracic CT images. Our purpose is the early detection of lung cancer leading to its early treatment, in order to reduce the mortality of lung cancer. From multi-slice CT, lung cancer screening has been activated more. Since CT screening contains a lot of images compared with the conventional X-ray, research and development on the utilization of computer and network using the new diagnosis support technology is required. Due to the demand from actual clinical site, the research group from The University of Tokushima has started the research and development of CAD using lung cancer CT images. We report the result and the future works. (author)

  8. 77 FR 62243 - Rural Health Network Development Program

    Science.gov (United States)

    2012-10-12

    ... HUMAN SERVICES Health Resources and Services Administration Rural Health Network Development Program... Network Development Program to the Siloam Springs Regional Health Cooperative, Inc. This non-competitive..., increase provider knowledge and effective use of health information technology and perform...

  9. Patient navigator programs, cancer disparities, and the patient protection and affordable care act.

    Science.gov (United States)

    Moy, Beverly; Chabner, Bruce A

    2011-01-01

    Patients in vulnerable population groups suffer disproportionately from cancer. The elimination of cancer disparities is critically important for lessening the burden of cancer. Patient navigator programs have been shown to improve clinical outcomes. Among its provisions relevant to disparities in cancer care, The Patient Protection and Affordability Care Act authorizes continued funding of patient navigator programs. However, given the current economic and political environment, this funding is in jeopardy. This article describes patient navigator programs and summarizes the elements of the health care law that are relevant to these programs. It is vital that the entire oncology community remain committed to leading efforts toward the improvement of cancer care among our most vulnerable patients. PMID:21804070

  10. Recommendations for cervical cancer screening programs in developing countries: the need for equity and technological development Recomendaciones a programas de detección oportuna de cáncer cervical en países en desarrollo: necesidad de equidad y desarrollo tecnológico

    Directory of Open Access Journals (Sweden)

    Eduardo Lazcano-Ponce

    2003-01-01

    Full Text Available The cervical cancer screening programs (CCSP have not been very efficient in the developing countries. This explains the need to foster changes on policies, standards, quality control mechanisms, evaluation and integration of new screening alternatives considered as low and high cost, as well as to regulate colposcopy practices and the foundation of HPV laboratories. Cervical cancer (CC is a disease most frequently found in poverty-stricken communities and reflecting a problem of equity at both levels gender and regional, and this, is not only due to social and economic development inequalities, but to the infrastructure and human resources necessary for primary care. For this reason, the CCSP program must be restructured, a to primarily address unprivileged rural and urban areas; b to foster actions aimed at ensuring extensive coverage as well as a similar quality of that coverage in every region; c to use screening strategies in keeping with the availability of health care services. In countries with a great regional heterogeneity, a variety of screening procedures must be regulated and standardized, including a combination of assisted visual inspection, cervical cytology and HPV detection; d regional community intervention must be set up to assess the effectiveness of using HPV detection as an strategy in addition to cervical cytology (pap smear; e the practice of colposcopy must be regulated to prevent the use of it in healthy women at a population level, thus preventing unnecessary diagnosis and treatment which not only are expensive but also causes unnecessary anxiety to women at risk; f the operation of those clinical laboratories using HPV as a detection strategy must likewise be accredited and regulated and g the CCSP program for assuring health care quality should meet the expectations of its beneficiaries, and increase the knowledge in cervical cancer related matters. Finally, though a variety of clinical tests on prophylactic and

  11. Telomerase targeting in cancer treatment : new developments

    NARCIS (Netherlands)

    Helder, MN; de Jong, S; de Vries, EGE; van der Zee, AGJ

    1999-01-01

    Telomerase, a ribonucleoprotein expressed in 85% of advanced cancers but not in most somatic cells, compensates for telomeric DNA erosion and as such stabilizes cell immortality. Telomerase inhibition might restore mortality in tumor cells. Recent progress is illustrated in studies on telomerase and

  12. Developing Successful International Faculty Led Program

    Science.gov (United States)

    Fabregas Janeiro, Maria G.; Fabre, Ricardo Lopez; Rosete, Rodrigo Tello

    2012-01-01

    Faculty Led Programs are study abroad experiences led by university professors. Faculty Led Programs are considered as an opportunity for college students, especially in the United States to attend a short-term international experience (Mills, 2010). Faculty Led Program is an international experience which is different from the traditional…

  13. CeraMem Filter Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Bishop, B. [CeraMem Corp., Waltham, MA (United States); Raskin, N. [CeraFilter L.P., San Diego, CA (United States)

    1996-12-31

    In gasification systems, the ash and char that is suspended in the syngas stream must be removed prior to the gas stream`s introduction to other downstream air pollution control systems (e.g., hydrogen sulfide removal). The char, once captured, can be reinjected into the gasification reactors to increase the overall system efficiency. If the ash and char are not captured before the other downstream equipment, these solids can foul process piping or columns and cause downtime for the entire system. This paper describes, in general, a development program between Ceramem Separations and Foster Wheeler for a high temperature ceramic filtration system to be sold by their partnership, CeraFilter L.P. In addition, detailed test results of ceramic filters operating at conditions approaching those of high temperature combustors are discussed. The successful development of this hot gas filtration system based upon the Ceramem ceramic-membrane-coated, monolithic filter will help address the critical challenges of particulate removal under the severe conditions imposed by advanced fossil energy power systems.

  14. Hot Dry Rock Geothermal Energy Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Smith, M.C.; Hendron, R.H.; Murphy, H.D.; Wilson, M.G.

    1989-12-01

    During Fiscal Year 1987, emphasis in the Hot Dry Rock Geothermal Energy Development Program was on preparations for a Long-Term Flow Test'' of the Phase II'' or Engineering'' hot dry rock energy system at Fenton Hill, New Mexico. A successful 30-day flow test of the system during FY86 indicated that such a system would produce heat at a temperature and rate that could support operation of a commercial electrical power plant. However, it did not answer certain questions basic to the economics of long-term operation, including the rate of depletion of the thermal reservoir, the rate of water loss from the system, and the possibility of operating problems during extended continuous operation. Preparations for a one-year flow test of the system to answer these and more fundamental questions concerning hot dry rock systems were made in FY87: design of the required surface facilities; procurement and installation of some of their components; development and testing of slimline logging tools for use through small-diameter production tubing; research on temperature-sensitive reactive chemical tracers to monitor thermal depletion of the reservoir; and computer simulations of the 30-day test, extended to modeling the planned Long-Term Flow Test. 45 refs., 34 figs., 5 tabs.

  15. Waste sludge resuspension and transfer: development program

    International Nuclear Information System (INIS)

    The six Gunite waste tanks at Oak Ridge National Laboratory (ORNL) contain about 400,000 gal of sludge that has precipitated from solution and settled during the 35 years these tanks have been in service. Eventual decommissioning of the tanks has been proposed. The first part of this program is to resuspend the accumulated sludge, to transfer it to new storage tanks in Melton Valley, and to dispose of it by the shale-fracturing process. On the basis of preliminary information, a tentative operational concept was adopted. The sludge in each tank would be resuspended by hydraulic sluicing and pumped from the tank. This resuspended sludge would be treated as necessary to keep the particles in suspension and would be pumped to the new waste-storage tanks. Subsequently the sludge would be pumped from the tanks, combined with a cement-base mix, and disposed of by the shale-fracturing facility. Verification of the feasibility of this concept required development effort on characterization of the sludge and development of techniques for resuspending the sludge and for keeping it in suspension. These development efforts are described in this report. Sections of the report describe both the known properties of the sludge and the tests of grinding methods investigated, discuss tests of various suspenders, describe tests with cement-base mixes, summarize hot-cell tests on actual sludge samples, and describe tests that were made at a mockup of a Gunite tank installation. On the basis of the tests made, it was concluded that reslurrying and resuspension of the sludge is quite feasible and that the suspensions can be made compatible with cement mixes

  16. Breast cancer correlates in a cohort of breast screening program participants in Riyadh, KSA

    OpenAIRE

    Fahad A. Al-Amri; Mohammed Y. Saeedi; Fatina M. Al-Tahan; Ali, Arwa M.; Shaker A. Alomary; Mostafa Arafa; Ibrahim, Ahmed K.; Kassim A. Kassim

    2015-01-01

    Background: Breast cancer is the first cancer among females in the Kingdom of Saudi Arabia, accounting for 27.4% of all newly diagnosed female cancers in 2010. There are several risk factors affecting the incidence of breast cancer where some factors influence the risk more than the others. Aim: We aimed to identify the different risk factors related to breast cancer among females participating in the breast-screening program in Riyadh, KSA. Methods: Based on data from phase-I of the br...

  17. Improving breast cancer control among Latinas: evaluation of a theory-based educational program.

    Science.gov (United States)

    Mishra, S I; Chavez, L R; Magaña, J R; Nava, P; Burciaga Valdez, R; Hubbell, F A

    1998-10-01

    The study evaluated a theory-based breast cancer control program specially developed for less acculturated Latinas. The authors used a quasi-experimental design with random assignment of Latinas into experimental (n = 51) or control (n = 37) groups that completed one pretest and two posttest surveys. The experimental group received the educational program, which was based on Bandura's self-efficacy theory and Freire's empowerment pedagogy. Outcome measures included knowledge, perceived self-efficacy, attitudes, breast self-examination (BSE) skills, and mammogram use. At posttest 1, controlling for pretest scores, the experimental group was significantly more likely than the control group to have more medically recognized knowledge (sum of square [SS] = 17.0, F = 6.58, p SS = 128.8, F = 39.24, p SS = 316.5, F = 9.63, p SS = 234.8, F = 153.33, p < .001). Cancer control programs designed for less acculturated women should use informal and interactive educational methods that incorporate skill-enhancing and empowering techniques. PMID:9768384

  18. Development of PROSTVAC immunotherapy in prostate cancer.

    Science.gov (United States)

    Singh, Parminder; Pal, Sumanta K; Alex, Anitha; Agarwal, Neeraj

    2015-01-01

    PROSTVAC immunotherapy is a heterologous prime-boost regimen of two different recombinant pox-virus vectors; vaccinia as the primary immunotherapy, followed by boosters employing fowlpox, to provoke immune responses against prostate-specific antigen. Both vectors contain transgenes for prostate-specific antigen and a triad of T-cell costimulatory molecules (TRICOM). In a placebo-controlled Phase II trial of men with minimally symptomatic, chemotherapy-naive metastatic castration-resistant prostate cancer, PROSTVAC was well tolerated and associated with a 44% reduction in death. With a novel mechanism of action, and excellent tolerability, PROSTVAC has the potential to dramatically alter the treatment landscape of prostate cancer, not only as a monotherapy, but also in combination with other novel agents, such as immune check point inhibitors and novel androgen receptor blockers. A Phase III trial recently completed accrual. PMID:26235179

  19. Graphic Evolution Witness the Development of Lung Cancer Translational Research

    Directory of Open Access Journals (Sweden)

    Chao ZHANG

    2016-06-01

    Full Text Available Lung cancer treatment has altered from conventional chemotherapy to targeted treatment, which now has been turned to the immunotherapy. Translational research has played an irreplaceable role during this progression which graphic evolution has witnessed. The evolution has gone through forest plot, KM-curve, waterfall plot, spider plot and timeline-area, showing us the refining concept and gradual process of lung cancer treatment undergoing from community towards individual. Even though the latest immunotherapy is getting increasingly hot, the result isn’t quite expected. Meanwhile, the limitations of conventional treatment still exist which require further research. This article will primarily illustrate the development of translational research of lung cancer via the aspect of curve evolution and analysis some abortive clinical trials in lung cancer surgery for inspiring the next graphic style and lung cancer treatment.

  20. [Graphic Evolution Witness the Development of Lung Cancer Translational Research].

    Science.gov (United States)

    Zhang, Chao; Zhong, Wenzhao

    2016-06-20

    Lung cancer treatment has altered from conventional chemotherapy to targeted treatment, which now has been turned to the immunotherapy. Translational research has played an irreplaceable role during this progression which graphic evolution has witnessed. The evolution has gone through forest plot, KM-curve, waterfall plot, spider plot and timeline-area, showing us the refining concept and gradual process of lung cancer treatment undergoing from community towards individual. Even though the latest immunotherapy is getting increasingly hot, the result isn't quite expected. Meanwhile, the limitations of conventional treatment still exist which require further research. This article will primarily illustrate the development of translational research of lung cancer via the aspect of curve evolution and analysis some abortive clinical trials in lung cancer surgery for inspiring the next graphic style and lung cancer treatment. PMID:27335306

  1. FPs have vital role in ensuring success of breast cancer screening programs

    OpenAIRE

    Cohen, L.

    1997-01-01

    SCREENING IS THE ONLY PROVEN STRATEGY for reducing breast cancer mortality in women older than 50. Over the last 9 years, 8 provinces and 2 (territories have established independent dedicated mammography programs. A recent workshop on screening programs was told that family physicians play a crucial role in the ultimate success of these programs because of their referral role.

  2. Admission criteria to the Danish Brain Cancer Program are moderately associated with magnetic resonance imaging findings

    DEFF Research Database (Denmark)

    Hill, Thomas Winther; Nielsen, Mie Kiszka; Nepper-Rasmussen, Jørgen

    2013-01-01

    The objective of this study was to evaluate the Danish Brain Cancer Program by examining the criteria for admission to the program and the results of magnetic resonance imaging (MRI) of the brain in 359 patients referred to the program at the Odense University Hospital during one year. The...

  3. Developing and implementing a minimum safety program

    International Nuclear Information System (INIS)

    This presentation highlighted the six elements of a basic safety program. These are: (1) management involvement, (2) hazard identification and control, (3) rules and work procedures, (4) training, (5) communication, and (6) incident and accident reporting and investigation. Steps to implement a safety program were described. The importance of measuring and auditing the program, and the importance of recognizing achievement in safe operations were emphasized. 5 diapositives

  4. Developing Program Management Leadership for Acquisition Reform

    OpenAIRE

    Neil McCown

    2011-01-01

    Proceedings Paper (for Acquisition Research Program) Recent reform measures in acquisition processes support the acquisition community''s long-established goal of providing warfighters with the highest quality and most cost-effective weapons systems. Since the role of the Program Manager remains pivotal to overall program success or failure, efforts to reform the acquisition community must supplement and expand traditional expectations of PMs, focusing on four key concepts: ensuring leader...

  5. Building an Integrative Outpatient Care Program for Breast Cancer Patients in Taiwan.

    Science.gov (United States)

    Lin, Yi-Hsien; Shiu, Jing-Huei; Chen, Fang-Pey; Chiu, Jen-Hwey

    2016-09-01

    Background Breast cancer patients may experience various symptoms that affect the quality of life significantly and they seek complementary and alternative medicine (CAM). To meet the needs of patients, we developed an integrative outpatient care program. Methods This program provided CAM consultation and acupuncture for breast cancer patients at Taipei Veterans General Hospital. The outcome measures included Medical Outcomes Study 12-Item Short-Form Health Survey (SF-12) and patient satisfaction questionnaires on the first visit (baseline) and at 6 months. Results Forty-five breast cancer patients were enrolled. All patients completed the study. The median age was 53.3 (±8.3). The symptoms most often experienced during previous cancer treatments were fatigue (35.6%), arthralgia (20%), nausea (6.7%), and insomnia (6.7%). The symptoms most wished to be diminished by the patients were arthralgia (22.2%), insomnia (17.8%), and fatigue (15.6%). Thirty-four patients (75.6%) had sought CAM therapy to reduce these symptoms. Fifteen patients (33.3%) received CAM consultation only and 30 (66.7%) received acupuncture in addition. Sixteen patients completed at least 6 sessions of acupuncture. No serious adverse effect was reported. In the SF-12 Questionnaire on all the patients, physical component summary (PCS) was 49.6 (±5.6) at baseline and 44.9 (±7.6) at 6 months (P = .001); the mental component summary (MCS) was 44.7 (±6.1) at baseline and 52.3 (±9.3) at 6 months (P research to build a model that integrates CAM with conventional medicine in Taiwan. PMID:26453537

  6. Dissimilar weld failure analysis and development program

    International Nuclear Information System (INIS)

    The problem of dissimilar weld cracking and failure is examined. This problem occurs in boiler superheater and reheater sections as well as main steam piping. Typically, a dissimilar weld joins low-alloy steel tubing such as Fe-2-1/4 Cr-1Mo to stainless steel tubing such as 321H and 304H. Cracking and failure occur in the low-alloy steel heat-affected zone very close to the weld interface. The 309 stainless steel filler previously used has been replaced with nickel-base fillers such as Inconel 132, Inconel 182, and Incoweld A. This change has extended the time to cracking and failure, but has not solved the problem. To illustrate and define the problem, the metallography of damaged and failed dissimilar welds is described. Results of mechanical tests of dissimilar welds removed from service are presented, and factors believed to be influential in causing damage and failure are discussed. In addition, the importance of dissimilar weldment service history is demonstrated, and the Dissimilar Weld Failure Analysis and Development Program is described. 15 figures

  7. Hydrogen hybrid vehicle engine development: Experimental program

    Energy Technology Data Exchange (ETDEWEB)

    Van Blarigan, P. [Sandia National Lab., Livermore, CA (United States)

    1995-09-01

    A hydrogen fueled engine is being developed specifically for the auxiliary power unit (APU) in a series type hybrid vehicle. Hydrogen is different from other internal combustion (IC) engine fuels, and hybrid vehicle IC engine requirements are different from those of other IC vehicle engines. Together these differences will allow a new engine design based on first principles that will maximize thermal efficiency while minimizing principal emissions. The experimental program is proceeding in four steps: (1) Demonstration of the emissions and the indicated thermal efficiency capability of a standard CLR research engine modified for higher compression ratios and hydrogen fueled operation. (2) Design and test a new combustion chamber geometry for an existing single cylinder research engine, in an attempt to improve on the baseline indicated thermal efficiency of the CLR engine. (3) Design and build, in conjunction with an industrial collaborator, a new full scale research engine designed to maximize brake thermal efficiency. Include a full complement of combustion diagnostics. (4) Incorporate all of the knowledge thus obtained in the design and fabrication, by an industrial collaborator, of the hydrogen fueled engine for the hybrid vehicle power train illustrator. Results of the CLR baseline engine testing are presented, as well as preliminary data from the new combustion chamber engine. The CLR data confirm the low NOx produced by lean operation. The preliminary indicated thermal efficiency data from the new combustion chamber design engine show an improvement relative to the CLR engine. Comparison with previous high compression engine results shows reasonable agreement.

  8. 78 FR 36520 - Rural Development Voucher Program

    Science.gov (United States)

    2013-06-18

    ... origin, age, disability, sex, gender identity, religion, reprisal, and where applicable, political... require alternative means of communication for program information (e.g., Braille, large print,...

  9. Reviewing a Reading Program: Professional Development Module. Facilitator's Guide

    Science.gov (United States)

    Kosanovich, Marcia; Jordan, Georgia; Arndt, Elissa; VanSciver, Mary; Wahl, Michelle; Rissman, Lila

    2008-01-01

    This "Facilitator's Guide" has been prepared for presenters of the Reviewing a Reading Program professional development training. It is one of three pieces comprising a suite of materials on reviewing reading programs: this "Guide", the "Reviewing a Reading Program Participant's Guide" and the "Reviewing a Reading Program" Professional Development…

  10. [Development of Nucleic Acid-Based Adjuvant for Cancer Immunotherapy].

    Science.gov (United States)

    Kobiyama, Kouji; Ishii, Ken J

    2015-09-01

    Since the discovery of the human T cell-defined tumor antigen, the cancer immunotherapy field has rapidly progressed, with the research and development of cancer immunotherapy, including cancer vaccines, being conducted actively. However, the disadvantages of most cancer vaccines include relatively weak immunogenicity and immune escape or exhaustion. Adjuvants with innate immunostimulatory activities have been used to overcome these issues, and these agents have been shown to enhance the immunogenicity of cancer vaccines and to act as mono-therapeutic anti-tumor agents. CpG ODN, an agonist for TLR9, is one of the promising nucleic acid-based adjuvants, and it is a potent inducer of innate immune effector functions. CpG ODN suppresses tumor growth in the absence of tumor antigens and peptide administration. Therefore, CpG ODN is expected to be useful as a cancer vaccine adjuvant as well as a cancer immunotherapy agent. In this review, we discuss the potential therapeutic applications and mechanisms of CpG ODN for cancer immunotherapy. PMID:26469159

  11. The iSBTc/SITC primer on tumor immunology and biological therapy of cancer: a summary of the 2010 program

    Directory of Open Access Journals (Sweden)

    Urba Walter J

    2011-01-01

    Full Text Available Abstract The Society for Immunotherapy of Cancer, SITC (formerly the International Society for Biological Therapy of Cancer, iSBTc, aims to improve cancer patient outcomes by advancing the science, development and application of biological therapy and immunotherapy. The society and its educational programs have become premier destinations for interaction and innovation in the cancer biologics community. For over a decade, the society has offered the Primer on Tumor Immunology and Biological Therapy of Cancer™ in conjunction with its Annual Scientific Meeting. This report summarizes the 2010 Primer that took place October 1, 2010 in Washington, D.C. as part of the educational offerings associated with the society's 25th anniversary. The target audience was basic and clinical investigators from academia, industry and regulatory agencies, and included clinicians, post-doctoral fellows, students, and allied health professionals. Attendees were provided a review of basic immunology and educated on the current status and most recent advances in tumor immunology and clinical/translational caner immunology. Ten prominent investigators presented on the following topics: innate immunity and inflammation; an overview of adaptive immunity; dendritic cells; tumor microenvironment; regulatory immune cells; immune monitoring; cytokines in cancer immunotherapy; immune modulating antibodies; cancer vaccines; and adoptive T cell therapy. Presentation slides, a Primer webinar and additional program information are available online on the society's website.

  12. Cathelicidin suppresses colon cancer development by inhibition of cancer associated fibroblasts

    Directory of Open Access Journals (Sweden)

    Cheng M

    2014-12-01

    Full Text Available Michelle Cheng,1,* Samantha Ho,1,* Jun Hwan Yoo,1,2,* Deanna Hoang-Yen Tran,1,* Kyriaki Bakirtzi,1 Bowei Su,1 Diana Hoang-Ngoc Tran,1 Yuzu Kubota,1 Ryan Ichikawa,1 Hon Wai Koon1 1Center for Inflammatory Bowel Diseases, Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; 2Digestive Disease Center, CHA University Bundang Medical Center, Seongnam, Republic of Korea *These authors share co-first authorship Background: Cathelicidin (LL-37 in humans and mCRAMP in mice represents a family of endogenous antimicrobial and anti-inflammatory peptides. Cancer-associated fibroblasts can promote the proliferation of colon cancer cells and growth of colon cancer tumors. Methods: We examined the role of cathelicidin in the development of colon cancer, using subcutaneous human HT-29 colon-cancer-cell-derived tumor model in nude mice and azoxymethane- and dextran sulfate-mediated colon cancer model in C57BL/6 mice. We also determined the indirect antitumoral mechanism of cathelicidin via the inhibition of epithelial–mesenchymal transition (EMT of colon cancer cells and fibroblast-supported colon cancer cell proliferation. Results: Intravenous administration of cathelicidin expressing adeno-associated virus significantly reduced the size of tumors, tumor-derived collagen expression, and tumor-derived fibroblast expression in HT-29-derived subcutaneous tumors in nude mice. Enema administration of the mouse cathelicidin peptide significantly reduced the size and number of colonic tumors in azoxymethane- and dextran sulfate-treated mice without inducing apoptosis in tumors and the adjacent normal colonic tissues. Cathelicidin inhibited the collagen expression and vimentin-positive fibroblast expression in colonic tumors. Cathelicidin did not directly affect HT-29 cell viability, but did significantly reduce tumor growth factor-ß1-induced EMT of colon cancer cells. Media conditioned by the

  13. Phase 0/I/II Cancer Prevention Clinical Trials Program Clinical Trials | Division of Cancer Prevention

    Science.gov (United States)

    The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

  14. RESULTS OF A GOAL-ORIENTED PROSTATE CANCER SCREENING PROGRAM IN THE PENZA REGION

    Directory of Open Access Journals (Sweden)

    F. Sh. Engalychev

    2014-07-01

    Full Text Available Prostate cancer (PC has been recently the most common male cancer disease. At the same time, its incidence is ever increasing. In this connection, PS screening is highly pressing.Objective: to study and assess the first results of a regional goal-oriented PC screening program in the Penza Region.Subjects and methods. The regional goal-oriented “Male Health” program for PC screening was launched in the Penza Region in February 2008. The serum level of prostate-specific antigen (PSA was detected in all 45-to-70-year men who had visited the region’s polyclinics and hospitals for any disease. Digital rectal and transrectal ultrasound studies were additionally performed in patients having the symptoms of lower urinary tract dysfunction. When the PSA level was > 4 ng/ml, multifocal biopsy was made through transperineal and transrectal accesses under ultrasound guidance, by using 12-24 points.Results. In February 2008 to June 2010, blood was tested for PSA in 55 of 103 patients. In 5910 (10.7% of them, its level (> 4 ng/ml was above the allowable limit. Multifocal prostate puncture biopsy was performed in 1695 patients with elevated PSA levels for further examination to rule out PC. The latter was established by the results of biopsy in 737 patients. The percentage of biopsy results positive for cancer was 38.9%. That of PC detected among all the men examined for serum PSA level was 1.3%.Conclusion. To elaborate programs for the early diagnosis and screening of PC is one of the priorities of the development of oncourology, which can considerably improve the results of treatment for this disease.

  15. Advanced Emissions Control Development Program: Phase III

    Energy Technology Data Exchange (ETDEWEB)

    G.T. Amrhein; R.T. Bailey; W. Downs; M.J. Holmes; G.A. Kudlac; D.A. Madden

    1999-07-01

    The primary objective of the Advanced Emissions Control Development Program (AECDP) is to develop practical, cost-effective strategies for reducing the emissions of air toxics from coal-fired boilers. The project goal is to effectively control air toxic emissions through the use of conventional flue gas clean-up equipment such as electrostatic precipitators (ESPs), fabric filters (baghouses - BH), and wet flue gas desulfurization systems (WFGD). Development work concentrated on the capture of trace metals, fine particulate, hydrogen chloride and hydrogen fluoride, with an emphasis on the control of mercury. The AECDP project is jointly funded by the US Department of Energy's Federal Energy Technology Center (DOE), the Ohio Coal Development Office within the Ohio Department of Development (OCDO), and Babcock and Wilcox, a McDermott company (B and W). This report discusses results of all three phases of the AECDP project with an emphasis on Phase III activities. Following the construction and evaluation of a representative air toxics test facility in Phase I, Phase II focused on characterization of the emissions of mercury and other air toxics and the control of these emissions for typical operating conditions of conventional flue gas clean-up equipment. Some general comments that can be made about the control of air toxics while burning a high-sulfur bituminous coal are as follows: (1) particulate control devices such as ESP's and baghouses do a good job of removing non-volatile trace metals, (2) particulate control devices (ESPs and baghouses) effectively remove the particulate-phase mercury, but the particulate-phase mercury was only a small fraction of the total for the coals tested, (3) wet scrubbing can effectively remove hydrogen chloride and hydrogen fluoride, and (4) wet scrubbers show good potential for the removal of mercury when operated under certain conditions, however, for certain applications, system enhancements can be required to achieve

  16. Illinois Breast and Cervical Cancer Program: Implementing Effective Public-Private Partnerships to Assure Population Health.

    Science.gov (United States)

    Handler, Arden S; Henderson, Vida A; Rosenfeld, Amy; Rankin, Kristin; Jones, Brenda; Issel, L Michele

    2015-01-01

    With the implementation of the Affordable Care Act (ACA), it is essential for the public health sector to elucidate its role with respect to its mission of assuring population health, and to clarify its role with respect to the private health care system. To that end, we examined the value added to the population health enterprise of successful public-private partnerships (PPPs) such as those found in the Illinois Breast and Cervical Cancer Program (IBCCP), the Centers for Disease Control and Prevention's (CDC's) National Breast and Cervical Cancer Early Detection Program (NBCCEDP) in Illinois. Key Informant (KI) interviews focused on IBCCP implementation were conducted with IBCCP lead agency (LA) program coordinators (n = 35/36) in winter 2012-2013. Analysis was conducted using Atlas.ti software. The KI interviews revealed the existence of highly developed PPPs between the IBCCP LAs and individual medical providers and hospitals across Illinois. The data suggest that the small amount of funding provided by IBCCP to each LA in Illinois has been used to build and sustain robust PPPs in the majority of the IBCCP communities. The PPPs developed through the IBCCP can be seen as an unplanned benefit of CDC's investment in breast and cervical health through the NBCCEDP. While the IBCCP/NBCCEDP might be considered a "boutique" categorical program which some may consider no longer necessary as individuals gain insurance under the ACA, the KI data underscore the critical role of public sector dollars, not only to serve individuals and communities directly but also to mobilize the private health care sector to act in partnership with public entities and become advocates for underserved communities. PMID:25470661

  17. Development of parallel/serial program analyzing tool

    International Nuclear Information System (INIS)

    Japan Atomic Energy Research Institute has been developing 'KMtool', a parallel/serial program analyzing tool, in order to promote the parallelization of the science and engineering computation program. KMtool analyzes the performance of program written by FORTRAN77 and MPI, and it reduces the effort for parallelization. This paper describes development purpose, design, utilization and evaluation of KMtool. (author)

  18. Cancer Control Programs in East Asia: Evidence From the International Literature

    OpenAIRE

    Moore, Malcolm A

    2014-01-01

    Cancer is a major cause of mortality and morbidity throughout the world, including the countries of North-East and South-East Asia. Assessment of burden through cancer registration, determination of risk and protective factors, early detection and screening, clinical practice, interventions for example in vaccination, tobacco cessation efforts and palliative care all should be included in comprehensive cancer control programs. The degree to which this is possible naturally depends on the reso...

  19. Predictors of adherence to a 12-week exercise program among men treated for prostate cancer: ENGAGE study.

    Science.gov (United States)

    Craike, Melinda; Gaskin, Cadeyrn J; Courneya, Kerry S; Fraser, Steve F; Salmon, Jo; Owen, Patrick J; Broadbent, Suzanne; Livingston, Patricia M

    2016-05-01

    Understanding the factors that influence adherence to exercise programs is necessary to develop effective interventions for people with cancer. We examined the predictors of adherence to a supervised exercise program for participants in the ENGAGE study - a cluster randomized controlled trial that assessed the efficacy of a clinician-referred 12-week exercise program among men treated for prostate cancer. Demographic, clinical, behavioral, and psychosocial data from 52 participants in the intervention group were collected at baseline through self-report and medical records. Adherence to the supervised exercise program was assessed through objective attendance records. Adherence to the supervised exercise program was 80.3%. In the univariate analyses, cancer-specific quality of life subscales (role functioning r = 0.37, P = 0.01; sexual activity r = 0.26, P = 0.06; fatigue r = -0.26, P = 0.06, and hormonal symptoms r = -0.31, P = 0.03) and education (d = -0.60, P = 0.011) were associated with adherence. In the subsequent multivariate analysis, role functioning (B = 0.309, P = 0.019) and hormonal symptoms (B = -0.483, P = 0.054) independently predicted adherence. Men who experienced more severe hormonal symptoms had lower levels of adherence to the exercise program. Those who experienced more positive perceptions of their ability to perform daily tasks and leisure activities had higher levels of adherence to the exercise program. Hormonal symptoms and role functioning need to be considered when conducting exercise programs for men who have been treated for prostate cancer. PMID:26872005

  20. What is the Radiotherapy Quality Program of the Instituto Nacional do Cancer - INCa?

    International Nuclear Information System (INIS)

    The Radiotherapy Quality Program (PQRT) of Cancer National Institute (INCA) has been functioning since 1999 as a pilot program with only 33 participant institutions. Due to the optimal obtained results the program becomes a part of the INCA National Programs and his activities were extended to all radiotherapy services which attend the Health Unique Systems (SUS), approximately 130 institutions corresponding to 90 percent of the radiotherapy services available in Brazil. The PQRT main objective is to make the radiotherapy to be evaluated as planned, in accordance with quality assurance international standards. The principal activities of the PQRT are: local evaluation, TLD postal evaluation under reference and non-reference conditions, and training and development of research projects. The Local Evaluation System has already evaluated 85 teletherapy equipment (38 Co-60 and 47 linear accelerators), executing dosimetric, electric, mechanic and safety tests. The TLD postal system used for the 33 participants until 2002 was the International Atomic Energy Agency (IAEA) for reference conditions. Five evaluations has already been performed with this simply system. Since 2003, the postal evaluation of the PQRT is using his own system, developed for reference and non-reference conditions, applied to 58 beams (18 Co-60 and 40 linear accelerators). The PQRT ras already performed 400 evaluations under reference conditions (190 Co-60 and 210 linear accelerators). 18 courses have been provided for the participants, covering his main practical problems. In addition, some studies and research has been performed

  1. Evolving Leaders. A Model for Promoting Leadership Development in Programs.

    Science.gov (United States)

    Palus, Charles J.; Drath, Wilfred H.

    A new model for promoting leadership development in programs emphasizes individuals' psychological development. The model, which is intended for use by individuals responsible for leadership development in organizations or by leadership development program planners/evaluators, is based on a cyclic process of three time-linked categories: readiness…

  2. Biology-driven cancer drug development: back to the future

    OpenAIRE

    Ashworth Alan; Lord Christopher J

    2010-01-01

    Abstract Most of the significant recent advances in cancer treatment have been based on the great strides that have been made in our understanding of the underlying biology of the disease. Nevertheless, the exploitation of biological insight in the oncology clinic has been haphazard and we believe that this needs to be enhanced and optimized if patients are to receive maximum benefit. Here, we discuss how research has driven cancer drug development in the past and describe how recent advances...

  3. Inguinal hernia developed after radical retropubic surgery for prostate cancer

    OpenAIRE

    Chung, Choon Sik; Jeong, Gyu Young; Kim, Seung Han; Lee, Dong Keun

    2013-01-01

    Purpose In this retrospective study, we aimed to compare the clinical characteristics of inguinal hernia developed after radical retropubic surgery for prostate cancer to the hernia without previous radical prostatectomy. Methods Twenty-three patients (group A) who had radical retropubic surgery for prostate cancer underwent laparoscopic or open tension-free inguinal hernia repair from March 2007 to February 2011. Nine hundred and forty patients (group B) without previous radical retropubic s...

  4. Radiation doses to screened women in the Norwegian Breast Cancer Screening Program in 2005 and 2006

    International Nuclear Information System (INIS)

    The radiographers report exposure data for approximately 50 women annually to the Norwegian Radiation Protection Authority. Based on reported data from all laboratories involved in the Norwegian Breast Cancer Screening Program average glandular dose (AGD) to the screened. (author)

  5. CAN RAP: A Program to Help Patients Choose a Screening Strategy for Colon Cancer

    OpenAIRE

    Detmer, William M.; Gilbertson, David G.

    1993-01-01

    The CANcer Risk Assessment and Preference (CAN RAP) system is a prototype computer program that helps patients to select a screening strategy for colon cancer. CAN RAP uses demographic and risk-factor information to calculate the benefit and cost of various screening strategies. The system communicates to patients these benefits and costs, and elicits patient preferences using audio, text, and graphics.

  6. An Effectiveness Study of a CBT Group Program for Women with Breast Cancer

    Science.gov (United States)

    Beatty, Lisa; Koczwara, Bogda

    2010-01-01

    Cognitive Behaviour Stress Management for women with breast cancer has demonstrable empirical efficacy, however its effectiveness in the applied clinical setting has not been examined to date in an Australian setting. A 10-week group program was offered to five women with early stage breast cancer. Clinical changes in distress, coping, and social…

  7. Cancer incidence and novel therapies developed in Japan

    Directory of Open Access Journals (Sweden)

    Masaru Iwasaki

    2012-01-01

    Full Text Available According to the ministry of Health, Labour and welfare of Japan, Cancer has been the leading cause of death in Japan since 1981. [1] As per the data in 2010, in Japan, one in every three deaths was due to cancer. [2] The Japanese Government has introduced so far, three terms of 10 years strategies for Cancer control since 1984 till date. The budget allocated for cancer control in 2009 was 52.5 billion yen in Japan. [3] Lung is the leading site for cancer in both males and females in Japan. In males, following the lung, stomach, liver, colon and pancreas are other leading sites while in the females, stomach, colon, pancreas and breast are the other leading sites.[1] In 2006, the cancer incidence was 694,000 and the male cancer incidence was 1.4 times as large as that of females. The peak age for cancer deaths in males is their fifties while in the females it is the sixties among Japanese. In addition to the conventional treatments such as surgery, radiotherapy and chemotherapy, some of other therapies in practice in Japan are the Hyperthermia [4] that uses high temperatures to kill or damage the cancer cells, the Ion Beam therapy using proton beams [5] to damage the DNA of the cells as cancer cells have high rate of cell divisions and lesser ability to repair DNA damage, the molecular targeted therapies that interfere with a specific molecular target involved in tumour growth and progression [6] and most importantly the autologous cell based Immunotherapies. Modern Cancer Immunotherapy started in the 1970s in Japan. The immunopotentiators using compounds from Bacteria, Beta Glucans from fungi were the first forms of modern Immunotherapy. Then was the era of direct injection of cytokines such as Interleukins, Interferons etc. The adverse effects associated with the injection of cytokines led to development of cell based Immunotherapies in the 1980s. [7] Immuno-cell therapies involve isolation of immune cells which are then processed and re

  8. Improving quality of breast cancer surgery through development of a national breast cancer surgical outcomes (BRCASO research database

    Directory of Open Access Journals (Sweden)

    Aiello Bowles Erin J

    2012-04-01

    Full Text Available Abstract Background Common measures of surgical quality are 30-day morbidity and mortality, which poorly describe breast cancer surgical quality with extremely low morbidity and mortality rates. Several national quality programs have collected additional surgical quality measures; however, program participation is voluntary and results may not be generalizable to all surgeons. We developed the Breast Cancer Surgical Outcomes (BRCASO database to capture meaningful breast cancer surgical quality measures among a non-voluntary sample, and study variation in these measures across providers, facilities, and health plans. This paper describes our study protocol, data collection methods, and summarizes the strengths and limitations of these data. Methods We included 4524 women ≥18 years diagnosed with breast cancer between 2003-2008. All women with initial breast cancer surgery performed by a surgeon employed at the University of Vermont or three Cancer Research Network (CRN health plans were eligible for inclusion. From the CRN institutions, we collected electronic administrative data including tumor registry information, Current Procedure Terminology codes for breast cancer surgeries, surgeons, surgical facilities, and patient demographics. We supplemented electronic data with medical record abstraction to collect additional pathology and surgery detail. All data were manually abstracted at the University of Vermont. Results The CRN institutions pre-filled 30% (22 out of 72 of elements using electronic data. The remaining elements, including detailed pathology margin status and breast and lymph node surgeries, required chart abstraction. The mean age was 61 years (range 20-98 years; 70% of women were diagnosed with invasive ductal carcinoma, 20% with ductal carcinoma in situ, and 10% with invasive lobular carcinoma. Conclusions The BRCASO database is one of the largest, multi-site research resources of meaningful breast cancer surgical quality data

  9. Improving quality of breast cancer surgery through development of a national breast cancer surgical outcomes (BRCASO) research database

    International Nuclear Information System (INIS)

    Common measures of surgical quality are 30-day morbidity and mortality, which poorly describe breast cancer surgical quality with extremely low morbidity and mortality rates. Several national quality programs have collected additional surgical quality measures; however, program participation is voluntary and results may not be generalizable to all surgeons. We developed the Breast Cancer Surgical Outcomes (BRCASO) database to capture meaningful breast cancer surgical quality measures among a non-voluntary sample, and study variation in these measures across providers, facilities, and health plans. This paper describes our study protocol, data collection methods, and summarizes the strengths and limitations of these data. We included 4524 women ≥18 years diagnosed with breast cancer between 2003-2008. All women with initial breast cancer surgery performed by a surgeon employed at the University of Vermont or three Cancer Research Network (CRN) health plans were eligible for inclusion. From the CRN institutions, we collected electronic administrative data including tumor registry information, Current Procedure Terminology codes for breast cancer surgeries, surgeons, surgical facilities, and patient demographics. We supplemented electronic data with medical record abstraction to collect additional pathology and surgery detail. All data were manually abstracted at the University of Vermont. The CRN institutions pre-filled 30% (22 out of 72) of elements using electronic data. The remaining elements, including detailed pathology margin status and breast and lymph node surgeries, required chart abstraction. The mean age was 61 years (range 20-98 years); 70% of women were diagnosed with invasive ductal carcinoma, 20% with ductal carcinoma in situ, and 10% with invasive lobular carcinoma. The BRCASO database is one of the largest, multi-site research resources of meaningful breast cancer surgical quality data in the United States. Assembling data from electronic

  10. Developing an online certification program for nutrition education assistants

    OpenAIRE

    Christofferson, D.; Christensen, N.; LeBlanc, Heidi; Bunch, M.

    2012-01-01

    Objective: To develop an online certification program for nutrition education paraprofessionals to increase knowledge and confidence and to overcome training barriers of programming time and travel expenses. Design: An online interactive certification course based on Supplemental Nutrition Assistance Program-Education and Expanded Food and Nutrition Education Program core competencies was delivered to employees of both programs. Traditional vs online training was compared. Course content vali...

  11. Fusion Energy Postdoctoral Research Program, Professional Development Program: FY 1987 annual report

    International Nuclear Information System (INIS)

    In FY 1986, Oak Ridge Associated Universities (ORAU) initiated two programs for the US Department of Energy (DOE), Office of Fusion Energy (OFE): the Fusion Energy Postdoctoral Research Program and the Fusion Energy Professional Development Program. These programs provide opportunities to conduct collaborative research in magnetic fusion energy research and development programs at DOE laboratories and contractor sites. Participants become trained in advanced fusion energy research, interact with outstanding professionals, and become familiar with energy-related national issues while making personal contributions to the search for solutions to scientific problems. Both programs enhance the national fusion energy research and development effort by providing channels for the exchange of scientists and engineers, the diffusion of ideas and knowledge, and the transfer of relevant technologies. These programs, along with the Magnetic Fusion Energy Science and Technology Fellowship Programs, compose the fusion energy manpower development programs administered by ORAU for DOE/OFE

  12. Leadership development program - useful? Which influence/impact have leadership development programs had to your development as a leader?

    OpenAIRE

    Totlund, Mariann

    2014-01-01

    This is a quantitative study where the main objective was to find out which influence/impact leadership development programs have had for leaders’ development. The basis was different theories within leadership development, leadership, gender differences in leadership, selfawareness, culture and honeymoon effect, reflection and conflict management. The data was gathered though a questionnaire deployed in six municipalities and leaders participating at the Masters of management, NTNU. There we...

  13. Thyroid cancer development in Chernobyl including new additional results

    International Nuclear Information System (INIS)

    Full text: We have been studying the etiology of thyroid cancer development among the exposed people in Hiroshima. In 1993, we have proposed the hypothesis of oncology model of thyroid cancer development in children following the nuclear power plant accident in Chernobyl, and then related studies has been done in Chernobyl and also in Hiroshima. Following findings are included. Urinary iodine level was lower in Chernobyl than in Hiroshima. Stimulation of ret oncogene in thyroid cancer tissues, and appearance of nuclear abnormalities of thyroid follicular cells were found higher rate among the exposed people. Sensitivity of TSH-receptor in thyroid tissues (TSH-R mRNA expression) was higher while young. Synergistic effect of TSH-R mRNA and ER mRNA expressions were found in both of normal tissues and cancer tissues in thyroid, but it was more apparent in cancer tissues. These findings gave the additional proofs on the hypothesis of thyroid cancer development in Chernobyl. Including these results, we like to present the importance of thyroid for the health of the exposed people in Chernobyl

  14. Edmonton Regional Palliative Care Program: impact on patterns of terminal cancer care

    OpenAIRE

    Bruera, E; Neumann, C M; Gagnon, B.; Brenneis, C; Kneisler, P; Selmser, P; J Hanson

    1999-01-01

    The Edmonton Regional Palliative Care Program was established in July 1995 to measure the access of patients with terminal cancer to palliative care services, decrease the number of cancer-related deaths in acute care facilities and increase the participation of family physicians in the care of terminally ill patients. In this retrospective study the authors compared the pattern of care and site of deaths before establishment of the program (1992/93) and during its second year of operation (1...

  15. Patient-Centered Cancer Care Programs in Italy: Benchmarking Global Patient Education Initiatives

    OpenAIRE

    Truccolo, Ivana; Cipolat Mis, Chiara; Cervo, Silvia; Dal Maso, Luigino; Bongiovanni, Marilena; Bearz, Alessandra; Sartor, Ivana; Baldo, Paolo; Ferrarin, Emanuela; Fratino, Lucia; Mascarin, Maurizio; Roncadin, Mario; Annunziata, Maria Antonietta; Muzzatti, Barbara; De Paoli, Paolo

    2015-01-01

    In Italy, educational programs for cancer patients are currently provided by the national government, scientific societies, and patient advocate organizations. Several gaps limit their effectiveness, including the lack of coordinated efforts, poor involvement of patient feedback in the planning of programs, as well as a lack of resources on innovative cancer-related topics. This process is parallel to a strong shift in the attitude of patients towards health in general and taking charge of th...

  16. Program Development Plan and Team up

    Energy Technology Data Exchange (ETDEWEB)

    Solar Electric Power Association

    2001-12-01

    The final summary report is a comprehensive view of TEAM-UP, with documented data, information, and experiences that SEPA has collected throughout the program, including lessons learned by participating ventures, and sections covering costs and other information on both large and small systems. This report also covers the barriers that TEAM-UP faced to PV commercialization at the beginning of the program, barriers the project was able to remove or reduce, and what barriers remain on the road ahead.

  17. Baseline Gas Turbine Development Program. Fourteenth quarterly progress report

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, F W; Wagner, C E

    1976-04-30

    Progress is reported for a Baseline Gas Turbine Development Program sponsored by the Heat Engine Systems Branch, Division of Transportation Energy Conservation (TEC) of the Energy Research and Development Administration (ERDA). Structurally, this program is made up of three parts: (1) documentation of the existing automotive gas turbine state-of-the-art; (2) conduction of an extensive component improvement program; and (3) utilization of the improvements in the design, and building of an Upgraded Engine capable of demonstrating program goals.

  18. Chromatin Repressive Complexes in Stem Cells, Development, and Cancer

    DEFF Research Database (Denmark)

    Laugesen, Anne; Helin, Kristian

    2014-01-01

    The chromatin environment is essential for the correct specification and preservation of cell identity through modulation and maintenance of transcription patterns. Many chromatin regulators are required for development, stem cell maintenance, and differentiation. Here, we review the roles of the...... polycomb repressive complexes, PRC1 and PRC2, and the HDAC1- and HDAC2-containing complexes, NuRD, Sin3, and CoREST, in stem cells, development, and cancer, as well as the ongoing efforts to develop therapies targeting these complexes in human cancer. Furthermore, we discuss the role of repressive...... complexes in modulating thresholds for gene activation and their importance for specification and maintenance of cell fate....

  19. Building a Long Distance Training Program to Enhance Clinical Cancer Research Capacity in Puerto Rico

    OpenAIRE

    Appleyard, Caroline B.; Antonia, Scott J; Daniel M. Sullivan; Santiago-Cardona, Pedro G.; Cáceres, William; Velez, Hector; Torres-Ruiz, Jose A.; Wright, Kenneth L.

    2015-01-01

    Barriers persist in the development and delivery of effective cancer therapies to under-represented minority populations. In Puerto Rico, cancer is the second leading cause of death, yet cancer research awareness and training opportunities remain somewhat limited on the island. These limitations hinder progress toward decreasing the cancer health disparities that exist within the Puerto Rican population. The predominantly Hispanic population of Puerto Rico is the focus of a partnership betwee...

  20. Computer Aided Design System for Developing Musical Fountain Programs

    Institute of Scientific and Technical Information of China (English)

    刘丹; 张乃尧; 朱汉城

    2003-01-01

    A computer aided design system for developing musical fountain programs was developed with multiple functions such as intelligent design, 3-D animation, manual modification and synchronized motion to make the development process more efficient. The system first analyzed the music form and sentiment using many basic features of the music to select a basic fountain program. Then, this program is simulated with 3-D animation and modified manually to achieve the desired results. Finally, the program is transformed to a computer control program to control the musical fountain in time with the music. A prototype system for the musical fountain was also developed. It was tested with many styles of music and users were quite satisfied with its performance. By integrating various functions, the proposed computer aided design system for developing musical fountain programs greatly simplified the design of the musical fountain programs.

  1. Cancer stem cells: a new approach to tumor development

    Directory of Open Access Journals (Sweden)

    Natália Cristina Ciufa Kobayashi

    2015-02-01

    Full Text Available Many theories have been proposed to explain the origins of cancer. Currently, evidences show that not every tumor cell is capable of initiating a tumor. Only a small part of the cancer cells, called cancer stem cells (CSCs, can generate a tumor identical to the original one, when removed from human tumors and transplanted into immunosuppressed mice. The name given to these cells comes from the resemblance to normal stem cells, except for the fact that their ability to divide is infinite. These cells are also affected by their microenvironment. Many of the signaling pathways, such as Wnt, Notch and Hedgehog, are altered in this tumoral subpopulation, which also contributes to abnormal proliferation. Researchers have found several markers for CSCs; however, much remains to be studied, or perhaps a universal marker does not even exist, since they vary among tumor types and even from patient to patient. It was also found that cancer stem cells are resistant to radiotherapy and chemotherapy. This may explain the re-emergence of the disease, since they are not completely eliminated and minimal amounts of CSCs can repopulate a tumor. Once the diagnosis in the early stages greatly increases the chances of curing cancer, identifying CSCs in tumors is a goal for the development of more effective treatments. The objective of this article is to discuss the origin of cancer according to the theory of stem cell cancer, as well as its markers and therapies used for treatment.

  2. Approaches to improve development methods for therapeutic cancer vaccines.

    Science.gov (United States)

    Ogi, Chizuru; Aruga, Atsushi

    2015-04-01

    Therapeutic cancer vaccines are an immunotherapy that amplify or induce an active immune response against tumors. Notably, limitations in the methodology for existing anti-cancer drugs may subsist while applying them to cancer vaccine therapy. A retrospective analysis was performed using information obtained from ClinicalTrials.gov, PubMed, and published articles. Our research evaluated the optimal methodologies for therapeutic cancer vaccines based on (1) patient populations, (2) immune monitoring, (3) tumor response evaluation, and (4) supplementary therapies. Failure to optimize these methodologies at an early phase may impact development at later stages; thus, we have proposed some points to be considered during the early phase. Moreover, we compared our proposal with the guidance for industry issued by the US Food and Drug Administration in October 2011 entitled "Clinical Considerations for Therapeutic Cancer Vaccines". Consequently, while our research was aligned with the guidance, we hope it provides further insights in order to predict the risks and benefits and facilitate decisions for a new technology. We identified the following points for consideration: (1) include in the selection criteria the immunological stage with a prognostic value, which is as important as the tumor stage; (2) select immunological assays such as phenotype analysis of lymphocytes, based on their features and standardize assay methods; (3) utilize optimal response criteria for immunotherapy in therapeutic cancer vaccine trials; and (4) consider supplementary therapies, including immune checkpoint inhibitors, for future therapeutic cancer vaccines. PMID:25746315

  3. Molecular mechanisms of prostate cancer development

    Czech Academy of Sciences Publication Activity Database

    Souček, Karel; Lincová, Eva; Staršíchová, Andrea; Pernicová, Zuzana; Vondráček, Jan; Machala, M.; Kozubík, Alois

    Brno, 2008. s. 11. ISBN 978-80-7013-474-0. [Aktuální problematika genetické toxikologie, 31. pracovní dny České a slovenské společnosti pro mutagenezi zevním prostředím Československé biologické společnosti. 12.05.2008-14.05.2008, Brno] R&D Projects: GA ČR(CZ) GA310/07/0961; GA ČR(CZ) GA204/07/0834 Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702 Keywords : prostate cancer * neuroendocrine differentiation * inflammation Subject RIV: BO - Biophysics

  4. Development of novel radiosensitizers for cancer therapy

    CERN Document Server

    Akamatsu, K

    2002-01-01

    The novel radiosensitizers for cancer therapy, which have some atoms with large X-ray absorption cross sections, were synthesized. The chemical and radiation (X-rays, W target, 100kVp) toxicities and the radiosensitivities to LS-180 human colon adenocarcinoma cells were also evaluated. 2,3,4,5,6-pentabromobenzylalcohol (PBBA) derivatives were not radiosensitive even around the maximum concentration. On the other hand, the hydrophilic sodium 2,4,6-triiodobenzoate (STIB) indicated meaningful radiosensitivity to the cells. Moreover, the membrane-specific radiosensitizers, cetyl fluorescein isthiocyanate (cetyl FITC), cetyl eosin isothiocyanate (cetyl br-FITC), cetyl erythrosin isothiocyanate (cetyl I-FITC), which aim for the membrane damage by X-ray photoabsorption on the target atoms, were localized in the plasma membrane. As the results of the colony formation assay, it was found that both cetyl FITC are similarly radiosensitive. In this report, we demonstrate the synthetic methods of the radiosensitizers, the...

  5. Creating Synergy: Essential Components of a Successful R25E Cancer Education Program

    OpenAIRE

    Gronemeyer, Suzanne A.

    2011-01-01

    For an R25E cancer research program to be a resounding success for both participating students and faculty, and to maintain federal funding, many synergistic elements are necessary. Essential components of the R25E Pediatric Oncology Education (POE) Program at St. Jude Children’s Research Hospital include 1) a unique focus, 2) a program director who is passionate about the program and who is enthusiastically supported by the institution, 3) committed and involved faculty mentors, 4) a current...

  6. A silent crisis: Cancer treatment in developing countries

    International Nuclear Information System (INIS)

    A dramatic rise in cancer across the developing world is stretching already limited resources and equipment. Shortages of qualified staff and equipment are growing constraints to treating cancer effectively. Some 5,000 radiotherapy machines are presently needed to help patients fight cancer. But the entire developing world has only about 2,200 such machines. Experts predict a long-term crisis in managing cancer, with an estimated five million new patients requiring radiation therapy every year. Meeting the challenge is not simply a matter of providing appropriate equipment. There must be sufficient trained and knowledgeable staff with clinical and medical physics expertise to deliver a safe and effective radiation dose. Appropriate facilities and radiation protection infrastructure for monitoring and regulatory control are needed. Moreover, cancer treatment must be carried out in a comprehensive context of prevention, early diagnosis, and adequate follow-up care. Providing essential equipment and training of staff to safely treat cancer patients in the developing world is of increasing importance to the IAEA. The Agency has assisted Ethiopia, Ghana, Mongolia, Namibia, and Uganda in establishing their first radiotherapy facilities. The IAEA also provides ongoing support to some 80 developing Member States in upgrading their radiotherapy facilities and providing staff with suitable training. Dosimetry and medical physics are an integral part of any medical treatment that uses ionizing radiation. With computerization, improved techniques are increasingly being used in developing countries to plan and treat patients in a wide range of medical therapies including teletherapy, brachytherapy, and the use of open drinkable or injectable sources. The IAEA works in partnership with the World Health Organisation (WHO) on most of its cancer projects. The WHO works to address the full spectrum of the health-disease continuum from prevention to end-of-life care. The role of the

  7. Breast Cancer Stage, Surgery, and Survival Statistics for Idaho’s National Breast and Cervical Cancer Early Detection Program Population, 2004–2012

    OpenAIRE

    Johnson, Christopher J.; Graff, Robert; Moran, Patti; Cariou, Charlene; Bordeaux, Susan

    2015-01-01

    Introduction The National Breast and Cervical Cancer Early Detection Program (NBCCEDP) provides access to breast and cervical cancer screening for low-income, uninsured, and underinsured women in all states and US territories. In Idaho, a rural state with very low breast and cervical cancer screening rates, this program is called Women’s Health Check (WHC). The program has been operating continuously since 1997 and served 4,719 enrollees in 2013. The objective of this study was to assess whet...

  8. Quality of working life of cancer survivors: development of a cancer-specific questionnaire

    OpenAIRE

    de Jong, Merel; Tamminga, Sietske J; de Boer, Angela G. E. M.; Frings-Dresen, Monique H. W.

    2015-01-01

    Purpose The aim of this study was to generate, and select quality of working life issues for the development of an initial version of the Quality of Working Life Questionnaire for Cancer Survivors (QWLQ-CS). Methods Quality of working life issues were generated through focus groups with cancer survivors and oncological occupational physicians, and interviews with employers, supervisors, and organization officers. A selection of these quality of working life issues was made based on relevance ...

  9. Development of lung cancer CT screening operating support system

    Science.gov (United States)

    Ishigaki, Rikuta; Hanai, Kozou; Suzuki, Masahiro; Kawata, Yoshiki; Niki, Noboru; Eguchi, Kenji; Kakinuma, Ryutaro; Moriyama, Noriyuki

    2009-02-01

    In Japan, lung cancer death ranks first among men and third among women. Lung cancer death is increasing yearly, thus early detection and treatment are needed. For this reason, CT screening for lung cancer has been introduced. The CT screening services are roughly divided into three sections: office, radiology and diagnosis sections. These operations have been performed through paper-based or a combination of paper-based and an existing electronic health recording system. This paper describes an operating support system for lung cancer CT screening in order to make the screening services efficient. This operating support system is developed on the basis of 1) analysis of operating processes, 2) digitalization of operating information, and 3) visualization of operating information. The utilization of the system is evaluated through an actual application and users' survey questionnaire obtained from CT screening centers.

  10. A Cost-Effective Mindfulness Stress Reduction Program: A Randomized Control Trial for Breast Cancer Survivors.

    Science.gov (United States)

    Lengacher, Cecile A; Kip, Kevin E; Reich, Richard R; Craig, Benjamin M; Mogos, Mulubrhan; Ramesar, Sophia; Paterson, Carly L; Farias, Jerrica R; Pracht, Etienne

    2015-01-01

    Many breast cancer survivors continue to experience residual symptoms including anxiety, cognitive impairment, depression, fatigue, and pain. In this study, the cost-effectiveness of a Mindfulness-Based Stress Reduction intervention for breast cancer survivors was examined. The cost of the program was assessed from the societal perspective, accounting for both direct medical and patient opportunity costs. The cost per quality-adjusted life year was relatively low compared to the cost-utility findings of other published breast cancer interventions. The program appears to provide for significantly improved health-related quality of life at a comparativelv low cost. PMID:26477119

  11. Development of A Mouse Model of Menopausal Ovarian Cancer

    Directory of Open Access Journals (Sweden)

    Elizabeth R. Smith

    2014-02-01

    Full Text Available Despite significant understanding of the genetic mutations involved in ovarian epithelial cancer and advances in genomic approaches for expression and mutation profiling of tumor tissues, several key questions in ovarian cancer biology remain enigmatic: the mechanism for the well-established impact of reproductive factors on ovarian cancer risk remains obscure; questions of the cell of origin of ovarian cancer continue to be debated; and the precursor lesion, sequence, or events in progression remain to be defined. Suitable mouse models should complement the analysis of human tumor tissues and may provide clues to these questions currently perplexing ovarian cancer biology.A potentially useful model is the germ cell-deficient Wv (white spotting variant mutant mouse line, which may be used to study the impact of menopausal physiology on the increased risk of ovarian cancer. The Wv mice harbor a point mutation in c-Kit that reduces the receptor tyrosine kinase activity to about 1-5% (it is not a null mutation. Homozygous Wv mutant females have a reduced ovarian germ cell reservoir at birth and the follicles are rapidly depleted upon reaching reproductive maturity, but other biological phenotypes are minimal and the mice have a normal life span. The loss of ovarian function precipitates changes in hormonal and metabolic activity that model features of menopause in humans. As a consequence of follicle depletion, the Wv ovaries develop ovarian tubular adenomas, a benign epithelial tumor corresponding to surface epithelial invaginations and papillomatosis that mark human ovarian aging. Ongoing work will test the possibility of converting the benign epithelial tubular adenomas into neoplastic tumors by addition of an oncogenic mutation, such as of Tp53, to model the genotype and biology of serous ovarian cancer.Model based on the Wv mice may have the potential to gain biological and etiological insights into ovarian cancer development and prevention.

  12. The development of a telemedical cancer center within the Veterans Affairs Health Care System: a report of preliminary clinical results.

    Science.gov (United States)

    Billingsley, Kevin G; Schwartz, David L; Lentz, Susan; Vallières, Eric; Montgomery, R Bruce; Schubach, William; Penson, David; Yueh, Bevan; Chansky, Howard; Zink, Claudia; Parayno, Darla; Starkebaum, Gordon

    2002-01-01

    In order to optimize the delivery of multidisciplinary cancer care to veterans, our institution has developed a regional cancer center with a telemedical outreach program. The objectives of this report are to describe the organization and function of the telemedical cancer center and to report our early clinical results. The Veterans Affairs Health Care System is organized into a series of integrated service networks that serve veterans within different areas throughout the United States. Within Veterans Integrated Service Network 20 (Washington, Alaska, Idaho, Oregon) we have developed a regional cancer center with telemedicine links to four outlying facilities within the service area. The telemedical outreach effort functions through the use of a multidisciplinary telemedicine tumor board. The tumor board serves patients in outlying facilities by providing comprehensive, multidisciplinary consultation for the complete range of malignancies. For individuals who do require referral to the cancer center, the tumor board serves to coordinate the logistical and clinical details of the referral process. This program has been in existence for 1 year. During that time 85 patients have been evaluated in the telemedicine tumor board. Sixty-two percent of the patients were treated at their closest facility; 38% were referred to the cancer center for treatment and/or additional diagnostic studies. The patients' diagnoses included the entire clinical spectrum of malignant disease. Preliminary clinical results demonstrate the program is feasible and it improves access to multidisciplinary cancer care. Potential benefits include improved referral coordination and minimization of patient travel and treatment delays. PMID:12020412

  13. Cancer control in developing countries: using health data and health services research to measure and improve access, quality and efficiency

    Directory of Open Access Journals (Sweden)

    Kangolle Alfred CT

    2010-10-01

    Full Text Available Abstract Background Cancer is a rapidly increasing problem in developing countries. Access, quality and efficiency of cancer services in developing countries must be understood to advance effective cancer control programs. Health services research can provide insights into these areas. Discussion This article provides an overview of oncology health services in developing countries. We use selected examples from peer-reviewed literature in health services research and relevant publicly available documents. In spite of significant limitations in the available data, it is clear there are substantial barriers to access to cancer control in developing countries. This includes prevention, early detection, diagnosis/treatment and palliation. There are also substantial limitations in the quality of cancer control and a great need to improve economic efficiency. We describe how the application of health data may assist in optimizing (1 Structure: strengthening planning, collaboration, transparency, research development, education and capacity building. (2 Process: enabling follow-up, knowledge translation, patient safety and quality assurance. (3 Outcome: facilitating evaluation, monitoring and improvement of national cancer control efforts. There is currently limited data and capacity to use this data in developing countries for these purposes. Summary There is an urgent need to improve health services for cancer control in developing countries. Current resources and much-needed investments must be optimally managed. To achieve this, we would recommend investment in four key priorities: (1 Capacity building in oncology health services research, policy and planning relevant to developing countries. (2 Development of high-quality health data sources. (3 More oncology-related economic evaluations in developing countries. (4 Exploration of high-quality models of cancer control in developing countries. Meeting these needs will require national, regional and

  14. Developing an interdisciplinary master's program in applied behavior analysis

    OpenAIRE

    Lowenkron, Barry; Mitchell, Lynda

    1995-01-01

    At many universities, faculty interested in behavior analysis are spread across disciplines. This makes difficult the development of behavior-analytically oriented programs, and impedes regular contact among colleagues who share common interests. However, this separation by disciplines can be a source of strength if it is used to develop interdisciplinary programs. In this article we describe how a bottom-up strategy was used to develop two complementary interdisciplinary MS programs in appli...

  15. Research and development program, fiscal year 1974

    Energy Technology Data Exchange (ETDEWEB)

    1972-04-01

    The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for Fiscal Year 1974 is conducted within the scope of the following categories: Effects of Radiation of Living Organisms; Molecular and Cellular Radiobiology; Land and Fresh Water Environmental Sciences; Radiological and Health Physics and Instrumentation; and Nuclear Medical Research. (ACR)

  16. Power engineering development strategy. White Earth program

    International Nuclear Information System (INIS)

    The brief description of the world power program the White Earth (WE) is presented. The WE system constitutes a set of small transportable NPPs with the Pb-Bi-coolant, operating without reloading about 10 years; thereafter they gp for reprocessing and are replaced as electric batteries by other analogous NPPs. The properties and advantages of such nuclear batteries are described

  17. Global Studies: Hurdles to Program Development

    Science.gov (United States)

    Campbell, Patricia J.; Masters, Paul E.; Goolsby, Amy

    2004-01-01

    In this article, we examine a new global studies program that departs from the traditional state-centric approach and uses a geocentric, or earth-centered, approach that emphasizes the roles of individuals, grassroots organizations, cultural groups, and international organizations in an attempt to help students conceptualize global events and…

  18. Higher Education Leadership Graduate Program Development

    Science.gov (United States)

    Freeman, Sydney, Jr.; Chambers, Crystal Renée; Newton, Rochelle

    2016-01-01

    Graduate programs in higher education administration and leadership have sought to equip students with the knowledge, skills, and competencies for higher education leadership; that is, to prepare globally minded leaders who can navigate the internal and external demands of, and for, higher education. With the use of the Lattuca and Stark model of…

  19. Effects of different phases of an invitational screening program on breast cancer incidence.

    Science.gov (United States)

    Seppänen, Johanna; Heinävaara, Sirpa; Anttila, Ahti; Sarkeala, Tytti; Virkkunen, Hanna; Hakulinen, Timo

    2006-08-15

    The aim of this study was to quantify the effects of separate phases of an invitational screening program on breast cancer incidence at different ages. Our database included detailed municipality-specific information about invitations for mass-screening for breast cancer in 267 Finnish municipalities from time period 1987-2001. The age range was 50-74. For this study, the program was divided into 7 separate phases, and those that had not been invited served as a baseline. The incidence rate was modeled using Poisson regression. To study the differences between age groups within each program phase, an interaction term between age group and phase of screening was included in the model. The modeling was done separately for localized breast cancers, nonlocalized breast cancers and all stages combined. For localized cancers, the risk compared to the noninvited increased during the first years of the 2-year screening rounds in all age groups, and declined below the baseline during the second years. This effect was larger during the first round compared to the subsequent ones. In nonlocalized cancers, a clear incidence peak was detected only during the first year of the first round. A decreasing post screening effect was detected in nonlocalized cancers in women aged 60-69, but not in localized cancers. Cumulating over ages 50-74, extra incidence caused by regular screening in localized cancers was 5.2% if the program was continued up to age 59, and 28.0% if it continued up to age 69. Corresponding figures for nonlocalized cancers were decreases of 19.8% and 20.9%, respectively. PMID:16550598

  20. Development and Implementation of an Effective Early Childhood Handicapped Program.

    Science.gov (United States)

    Condon, Kathryn; Dahlstrom, Mark

    The paper describes the Early Childhood Handicapped Program of Kenosha (WI). The program focuses on receptive and expressive language, fine and gross motor skills, self-help skills, cognitive skills, perceptual skills, and social/emotional skills development. For admission into the program, children must exhibit significant delays in two or more…

  1. Development and Operation of a Voluntary Audit Program.

    Science.gov (United States)

    Murphy, Jerome R.

    This report describes a voluntary audit program implemented by the Educational Testing Service (ETS). The comprehensive audit program was developed to assure that all corporate programs adhere to the ETS Standards for Quality and Fairness. The standards address issues which relate to all ETS activities such as accountability, confidentiality of…

  2. Developing an Online Certification Program for Nutrition Education Assistants

    Science.gov (United States)

    Christofferson, Debra; Christensen, Nedra; LeBlanc, Heidi; Bunch, Megan

    2012-01-01

    Objective: To develop an online certification program for nutrition education paraprofessionals to increase knowledge and confidence and to overcome training barriers of programming time and travel expenses. Design: An online interactive certification course based on Supplemental Nutrition Assistance Program-Education and Expanded Food and…

  3. The Voice of Youth: Atmosphere in Positive Youth Development Program

    Science.gov (United States)

    Ward, Stefan; Parker, Melissa

    2013-01-01

    Background: Positive youth development (PYD) programs adhere to the notion that all children have strengths and assets to be promoted and nurtured rather than deficits that require "fixing." The study of PYD programs indicates three aspects which set them apart from other programs for youth: activities, goals, and atmosphere. Of these,…

  4. Incorporating person centred care principles into an ongoing comprehensive cancer management program: An experiential account

    Directory of Open Access Journals (Sweden)

    Vallath Nandini

    2011-01-01

    Full Text Available Recent research indicates a definite positive impact on treatment outcomes when an integrative approach that focuses on symptom control and quality of life is provided along with the standard therapeutic regimens. However implementation or practice of this approach is not seen widely due to the culture of medical training and practice. This article presents the initial development of a program for incorporating integrative care principles into an ongoing comprehensive cancer care program at a tertiary centre. The key purpose of the program being to develop, facilitate, and establish comprehensive and holistic processes including palliative care principles, that would positively enhance the quantity and quality of life of the person with disease, as well as create an environment that reflects and sustains this approach. The vision, objectives, goals, strategies, activities and results within the 7 months of implementation are documented. The new learnings gained during the process have also been noted in the hope that the model described may be used to conceptualize similar care giving facilities in other centres.

  5. Adaptation of an Evidence-Based Colorectal Cancer Screening Program Using the Consolidated Framework for Implementation Research

    OpenAIRE

    Cole, Allison M; Esplin, Andrea; Baldwin, Laura-Mae

    2015-01-01

    Introduction Federally Qualified Health Centers (FQHCs) provide primary care to low-income and uninsured patients in the United States. FQHCs are required to report annual measurements and provide evidence of improvement for quality measures; effective methods to improve quality in FQHCs are needed. Systems of Support (SOS) is a proactive, mail-based, colorectal cancer screening program that was developed and tested in an integrated health care system. The objective of this study was to adapt...

  6. AECL's research and development program in environmental science and technology

    International Nuclear Information System (INIS)

    AECL's radiological research and development (R and D) program encompasses work on sources of radiation exposure, radionuclide transport through the environment and potential impacts on biota and on human health. The application of the radiation protection knowledge and technology developed in this program provides cradle-to-grave management for CANDU and related nuclear technologies. This document provides an overview of the Environmental Science and Technology (ES and T) program which is one of the technical areas of R and D within the radiological R and D program. The ES and T program uses science from three main areas: radiochemistry, mathematical modelling and environmental assessment. In addition to providing an overview of the program, this summary also gives specific examples of recent technical work in each of the three areas. These technical examples illustrate the applied nature of the ES and T program and the close coupling of the program to CANDU customer requirements. (author)

  7. The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer

    DEFF Research Database (Denmark)

    Roura, Esther; Travier, Noémie; Waterboer, Tim; de Sanjosé, Silvia; Bosch, F Xavier; Pawlita, Michael; Pala, Valeria; Weiderpass, Elisabete; Margall, Núria; Dillner, Joakim; Gram, Inger T; Tjønneland, Anne; Munk, Christian; Palli, Domenico; Khaw, Kay-Tee; Overvad, Kim; Clavel-Chapelon, Françoise; Mesrine, Sylvie; Fournier, Agnès; Fortner, Renée T; Ose, Jennifer; Steffen, Annika; Trichopoulou, Antonia; Lagiou, Pagona; Orfanos, Philippos; Masala, Giovanna; Tumino, Rosario; Sacerdote, Carlotta; Polidoro, Silvia; Mattiello, Amalia; Lund, Eiliv; Peeters, Petra H; Bueno-de-Mesquita, H B As; Quirós, J Ramón; Sánchez, María-José; Navarro, Carmen; Barricarte, Aurelio; Larrañaga, Nerea; Ekström, Johanna; Lindquist, David; Idahl, Annika; Travis, Ruth C; Merritt, Melissa A; Gunter, Marc J; Rinaldi, Sabina; Tommasino, Massimo; Franceschi, Silvia; Riboli, Elio; Castellsagué, Xavier

    2016-01-01

    BACKGROUND: In addition to HPV, high parity and hormonal contraceptives have been associated with cervical cancer (CC). However, most of the evidence comes from retrospective case-control studies. The aim of this study is to prospectively evaluate associations between hormonal factors and risk of...... developing cervical intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS) and invasive cervical cancer (ICC). METHODS AND FINDINGS: We followed a cohort of 308,036 women recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. At enrollment, participants.......7). CONCLUSIONS: Even though HPV is the necessary cause of CC, our results suggest that several hormonal factors are risk factors for cervical carcinogenesis. Adherence to current cervical cancer screening guidelines should minimize the increased risk of CC associated with these hormonal risk factors....

  8. Biofuels Feedstock Development Program annual progress report for 1991

    Energy Technology Data Exchange (ETDEWEB)

    Wright, L.L.; Cushman, J.H.; Ehrenshaft, A.R.; McLaughlin, S.B.; McNabb, W.A.; Ranney, J.W.; Tuskan, G.A.; Turhollow, A.F.

    1992-12-01

    This report provides an overview of the ongoing research funded in 1991 by the Department of Energy's Biofuels Feedstock Development Program (BFDP). The BFDP is managed by the Environmental Sciences Division of the Oak Ridge National Laboratory and encompasses the work formerly funded by the Short Rotation Woody Crops Program and the Herbaceous Energy Crops Program. The combined program includes crop development research on both woody and herbaceous energy crop species, cross-cutting energy and environmental analysis and integration, and information management activities. Brief summaries of 26 different program activities are included in the report.

  9. Biofuels Feedstock Development Program annual progress report for 1991

    Energy Technology Data Exchange (ETDEWEB)

    Wright, L.L.; Cushman, J.H.; Ehrenshaft, A.R.; McLaughlin, S.B.; McNabb, W.A.; Ranney, J.W.; Tuskan, G.A.; Turhollow, A.F.

    1992-12-01

    This report provides an overview of the ongoing research funded in 1991 by the Department of Energy`s Biofuels Feedstock Development Program (BFDP). The BFDP is managed by the Environmental Sciences Division of the Oak Ridge National Laboratory and encompasses the work formerly funded by the Short Rotation Woody Crops Program and the Herbaceous Energy Crops Program. The combined program includes crop development research on both woody and herbaceous energy crop species, cross-cutting energy and environmental analysis and integration, and information management activities. Brief summaries of 26 different program activities are included in the report.

  10. Targeting hedgehog signaling in cancer: research and clinical developments

    Directory of Open Access Journals (Sweden)

    Xie J

    2013-10-01

    Full Text Available Jingwu Xie, Christopher M Bartels, Scott W Barton, Dongsheng GuWells Center for Pediatric Research, Division of Hematology and Oncology, Department of Pediatrics, Indiana University Simon Cancer Center, Indiana University, Indianapolis, IN, USAAbstract: Since its first description in Drosophila by Drs Nusslein-Volhard and Wieschaus in 1980, hedgehog (Hh signaling has been implicated in regulation of cell differentiation, proliferation, tissue polarity, stem cell maintenance, and carcinogenesis. The first link of Hh signaling to cancer was established through studies of Gorlin syndrome in 1996 by two independent teams. Later, it was shown that Hh signaling may be involved in many types of cancer, including skin, leukemia, lung, brain, and gastrointestinal cancers. In early 2012, the US Food and Drug Administration approved the clinical use of Hh inhibitor Erivedge/vismodegib for treatment of locally advanced and metastatic basal cell carcinomas. With further investigation, it is possible to see more clinical applications of Hh signaling inhibitors. In this review, we will summarize major advances in the last 3 years in our understanding of Hh signaling activation in human cancer, and recent developments in preclinical and clinical studies using Hh signaling inhibitors.Keywords: hedgehog, smoothened, PTCH1, cancer, signal transduction, clinical trials, animal model

  11. Laboratory Directed Research and Development Program

    International Nuclear Information System (INIS)

    This report is compiled from annual reports submitted by principal investigators following the close of fiscal year 1993. This report describes the projects supported and summarizes their accomplishments. The program advances the Laboratory's core competencies, foundations, scientific capability, and permits exploration of exciting new opportunities. Reports are given from the following divisions: Accelerator and Fusion Research, Chemical Sciences, Earth Sciences, Energy and Environment, Engineering, Environment -- Health and Safety, Information and Computing Sciences, Life Sciences, Materials Sciences, Nuclear Science, Physics, and Structural Biology

  12. Effective Strategic Programming for Java Developers

    OpenAIRE

    Balland, Emilie; Moreau, Pierre-Etienne; Reilles, Antoine

    2014-01-01

    In object programming languages, the Visitor design pattern allows separation of algorithms and data-structures. When applying this pattern to tree-like structures, programmers are always confronted with the difficulty of making their code evolve. One reason is that the code implementing the algorithm is interwound with the code implementing the traversal inside the Visitor. When implementing algorithms such as data analyses or transformations, encoding the traversal directly into the algorit...

  13. Development of Ambulatory Quality Assurance Program Using Computerized Medical Records

    OpenAIRE

    Shrader, J.; Wright, C; Mieczkowski, L.; McDonald, S.

    1993-01-01

    As part of the computerization of the ambulatory teaching facility for our residency program, we have successfully utilized a comprehensive computerized medical records system to develop a specific quality assurance program. Our QA program includes allergy audits, health screening audits, drug utilization and recall audits, and nursing care plan audits. With a computerized QA program, specific question about individual patients as well as questions regarding our patient population are quickly...

  14. Empirical Studies of Agile Software Development to Learn Programming Skills

    OpenAIRE

    Yasuyo Kofune; Takahiro Koita

    2014-01-01

    This paper presents a programming education support method based on Agile Development that encourages and builds on communication between students. Through mutual discussion, students using our approach transform their ideas into software and cooperate to write a program. The students complete the software through repetition and programming. Before completing the software program, the students learn to solve problems by working together. The students are encouraged to think and share ideas, a...

  15. PDQ-8 reference manual (LWBR development program)

    International Nuclear Information System (INIS)

    The PDQ-8 program is designed to solve the neutron diffusion, depletion problem in one, two, or three dimensions on the CDC-6600 and CDC-7600 computers. The three dimensional spatial calculation may be either explicit or discontinuous trial function synthesis. Up to five lethargy groups are permitted. The fast group treatment may be simplified P(3), and the thermal neutrons may be represented by a single group or a pair of overlapping groups. Adjoint, fixed source, one iteration, additive fixed source, eigenvalue, and boundary value calculations may be performed. The HARMONY system is used for cross section variation and generalized depletion chain solutions. The depletion is a combination gross block depletion for all nuclides as well as a fine block depletion for a specified subset of the nuclides. The geometries available include rectangular, cylindrical, spherical, hexagonal, and a very general quadrilateral geometry with diagonal interfaces. All geometries allow variable mesh in all dimensions. Various control searches as well as temperature and xenon feedbacks are provided. The synthesis spatial solution time is dependent on the number of trial functions used and the number of gross blocks. The PDQ-8 program is used at Bettis on a production basis for solving diffusion--depletion problems. The report describes the various features of the program and then separately describes the input required to utilize these features

  16. Radiotherapy in Palliative Cancer Care: Development and Implementation

    International Nuclear Information System (INIS)

    It is estimated that in 2008 there were over 12 million new cancer diagnoses and 7 million cancer deaths worldwide. The World Health Organisation (WHO) predicts that cancer rates will increase from 10 million to 24 million in the next 50 years. More than half of cancer cases will be diagnosed in low income nations, where 80% or more of patients will have incurable disease at diagnosis. In situations where most patients are diagnosed with incurable disease or where curative treatment is logistically unavailable, as is the case in many low income countries, the allocation of limited health care resources should reflect a greater emphasis on palliative care. Ironically, access to palliative care is greater in health care systems with well developed infrastructures and facilities for prevention, early detection, and curative treatment of cancer. To provide comprehensive cancer care, a multidisciplinary approach is needed. This maximizes the available treatments and interventions, whilst ensuring a cost effective and ethically sound approach to the treatment of patients at each stage of the disease. Barriers to palliative care may result from its low prioritization in health care policy and education. The WHO expert committee on cancer pain and palliative care report of 1990 called for the integration of efforts directed at maintaining patient quality of life through all stages of cancer treatment. As a result supportive interventions aimed at improving quality of life are needed for patients undergoing both curative and palliative cancer treatment. The International Atomic Energy Agency is currently collaborating with the Open Society Institute to develop palliative care programmes in Eastern Europe, Africa and India, as well as supporting programmes in other regions of the world, through the International Palliative Care Initiative. OSI partners with the IAEA's Programme of Action for Cancer Therapy, the World Health Organization, the International Agency for Research

  17. Faculty Development Program Models to Advance Teaching and Learning Within Health Science Programs

    OpenAIRE

    Lancaster, Jason W.; Stein, Susan M.; MacLean, Linda Garrelts; Van Amburgh, Jenny; Persky, Adam M.

    2014-01-01

    Within health science programs there has been a call for more faculty development, particularly for teaching and learning. The primary objectives of this review were to describe the current landscape for faculty development programs for teaching and learning and make recommendations for the implementation of new faculty development programs. A thorough search of the pertinent health science databases was conducted, including the Education Resource Information Center (ERIC), MEDLINE, and EMBAS...

  18. Recurrence after surgery due to cervical cancer - An evaluation of the follow-up program

    DEFF Research Database (Denmark)

    Fuglsang, Katrine; Petersen, Lone Kjeld; Blaakær, Jan

    , Aarhus University Hospital we identified 567 patients from 1996 to 2011 matching the diagnosis cervical cancer combined with a surgical procedure. From the Danish Pathology Data Bank the following information is collected: - Stage of disease - Histology - Surgical procedure - Number of follow-up visit......Objective During the last 20 years the follow-up program after surgical treatment for cervical cancer has remained unchanged. Surprisingly, little is communicated in relation to the follow-up program even though it has a huge impact on the life of the women and their relatives for five years...... consequences, but there is a need for a foundation prior to an adjustment of the follow-up program. Methods Design: retrospective study of a cohort of women attending follow-up program after surgery due to cervical cancer. Material: From the patient register at the Department of Gynaecology and Obstetrics...

  19. Development of cancer therapy facility of HANARO

    International Nuclear Information System (INIS)

    Facilities of the research and clinical treatments of neutron capture therapy using HANARO are developed, and they are ready to install. They are BNCT irradiation facility and prompt gamma neutron activatiion analysis facility. Since every horizontal neutron facility of HANARO is long and narrow tangential beam tube, it is analysed that sufficient epithermal neutrons for the BNCT cannot be obtained but sufficient thermal neutrons can be obtained by a filter composed of silicon and bismuth single crystals. Since the thermal neutron penetaration increases significantly when the crystals are cooled, a filter cooled by liquid nitrogen is developed. So as to avoid interference with the reactor operation, a water shutter is developed. The irradiation room is designed for the temporary surgical operation as well. Handling tools to remove activated beam port plug and to install water shutter and filter are developed. The basic structure of the irradiation room is already installed and most of other parts are ready to install. Since no free beam port is available for the prompt gamma neutron activation analysis, a method obtaining almost pure thermal neutrons by the vertical diffraction of extra beam for the polarized neutron spectrometer is developed. This method is confirmed by analysis and experiments to give high enough neutron beam. Equipment and devices are provided to install this facility

  20. Developing Metrics in Systems Integration (ISS Program COTS Integration Model)

    Science.gov (United States)

    Lueders, Kathryn

    2007-01-01

    This viewgraph presentation reviews some of the complications in developing metrics for systems integration. Specifically it reviews a case study of how two programs within NASA try to develop and measure performance while meeting the encompassing organizational goals.

  1. Development of an environmental training program

    International Nuclear Information System (INIS)

    Argonne National Laboratory and Bethel New Life have joined to develop training and job opportunities in the environmental restoration field. The Argonne-Bethel partnership began in 1993 as an opportunity for Argonne to help an older, inner-city community revitalize itself. Argonne saw this as an opportunity to use technology being developed at the laboratory, particularly in the areas of brown fields recovery, development of recycling, energy-efficient building rehabilitation, and environmental training

  2. Center Independent Research & Developments: JPL IRAD Program

    Data.gov (United States)

    National Aeronautics and Space Administration — Innovative projects are sought in the areas of basic research, fundamental research, applied research, development and systems and other concept formulation...

  3. A Woman-centered Educational Program for Primary Prevention of Lung Cancer in a Cuban Municipality, 2012--2013.

    Science.gov (United States)

    Cruz, Abel; Castillo, Zeida; Pérez, Julia; Abeledo, Ahyní

    2015-10-01

    Lung cancer educational programs seek the involvement of different groups in efforts to promote healthier habits and lifestyles. Women are primary agents for targeting prevention actions because of their ability to foster healthy lifestyles within their families. The purpose of this study was to develop a woman-centered educational program to strengthen knowledge and promote responsible behavior aimed at primary prevention of lung cancer. Based on identified learning needs in 133 female participants concerning lung cancer self care, healthy habits and communication skills about self care, a ten-workshop series was designed and validated by specialists and users. Before intervention, 82% of participants were highly aware of smoking-related harm, but only 26% were highly aware of healthy environmental management practices at home and 14% were knowledgeable about self care. Differences in both awareness and practice of health-promoting behaviors were observed by the end of the training: those highly aware of smoking-related harm rose to 86.5%, and those highly aware of environmental management and self care increased to 66.2% and 83.5%, respectively. The proportions reporting acceptable levels of environmental management and self-care practices increased to 86.5% (from 0%) and 91% (from 3.8%), respectively. One year later, a positive impact on families was confirmed, predominantly on children. We conclude that such a woman-centered educational program can increase awareness and promote healthy behaviors aimed at lung cancer prevention. Women's ability to communicate and share lessons learned within their families should be considered in designing community health education programs. KEYWORDS Lung cancer, health education, disease prevention, primary prevention, health promotion, Cuba. PMID:26947281

  4. Transfer of Training in an Academic Leadership Development Program for Program Coordinators

    Science.gov (United States)

    Ladyshewsky, Richard K.; Flavell, Helen

    2012-01-01

    The higher education sector has increasingly begun to pay more attention to academic leadership. This qualitative study explores how such an investment in a 20-week leadership development program influenced the behaviour of 10 academic staff in the role of program coordinator 6 to 12 months following participation in the program. Otherwise known…

  5. Development of an Actuarial Science Program at Salisbury University

    Science.gov (United States)

    Wainwright, Barbara A.

    2014-01-01

    This paper focuses on the development of an actuarial science track for the mathematics major at Salisbury University (SU). A timeline from the initial investigation into such a program through the proposal and approval processes is shared for those who might be interested in developing a new actuarial program. It is wise to start small and take…

  6. Talent Development Middle Grades Program. What Works Clearinghouse Intervention Report

    Science.gov (United States)

    What Works Clearinghouse, 2013

    2013-01-01

    The "Talent Development Middle Grades Program" is a comprehensive reform model that transforms the structure and curriculum of large urban middle schools with the aim of improving student achievement and raising teacher and student expectations. Key features of the "Talent Development Middle Grades Program" include small learning communities, an…

  7. Youth Sport Programs: An Avenue to Foster Positive Youth Development

    Science.gov (United States)

    Fraser-Thomas, Jessica L.; Cote, Jean; Deakin, Janice

    2005-01-01

    Concern about the growth in adolescent problem behaviours (e.g. delinquency, drug use) has led to increased interest in positive youth development, and a surge in funding for "after school programs." We evaluate the potential of youth sport programs to foster positive development, while decreasing the risk of problem behaviours. Literature on the…

  8. A Guide for the Development of an Inservice Education Program.

    Science.gov (United States)

    Froberg, Signe E.

    This document suggests several things: a process for developing an inservice education program; suggested definition, philosophy, and objectives of inservice education; guidelines to assist in developing and maintaining an effective inservice education program; and a four-step job instructor training method which involves consecutively preparing…

  9. Placental programming of chronic diseases, cancer and lifespan: a review.

    Science.gov (United States)

    Barker, D J P; Thornburg, K L

    2013-10-01

    Particular paths of fetal growth are now known to predict a range of disorders in adult life. This is thought to reflect fetal programming, the phenomenon whereby nutrition and other influences during development set the body's organs and systems for life. The thesis of this review is that normal variations in the processes of placental development lead to variations in the supply of nutrients to the fetus and programme a small number of key systems that are linked to later disease. A baby's growth and nutrition depend both on the function of the placenta, reflected in its gross morphology at birth, and on the mother's lifetime nutrition, reflected in her height and weight. In many studies, the effects of placental size and shape on later disease have been examined within different categories of mother's body size. The review shows that variations in gross placental morphology at birth predict a wide range of disorders in later life. Any particular placental phenotype seems to predict a limited number of diseases. Further research into the links between the processes of placentation and the morphology of the placenta at birth is now required. We need to know more about the relative importance of nutrient flow, nutrient balance and the timing of nutritional events in determining disorders in later life. We also need to understand why, compared to other placental mammals, the human placenta is so variable in its morphology and functional capacity. PMID:23916422

  10. Development of a Barbershop-Based Cancer Communication Intervention

    Science.gov (United States)

    Holt, Cheryl L.; Wynn, Theresa A.; Lewis, Ivey; Litaker, Mark S.; Jeames, Sanford; Huckaby, Francine; Stroud, Leonardo; Southward, Penny L.; Simons, Virgil; Lee, Crystal; Ross, Louis; Mitchell, Theodies

    2009-01-01

    Purpose: Prostate and colorectal cancer (CRC) rates are disproportionately high among African-American men. The purpose of this paper is to describe the development of an intervention in which barbers were trained to educate clients about early detection for prostate and CRC. Design/methodology/approach: Working with an advisory panel of local…

  11. Business models and opportunities for cancer vaccine developers.

    Science.gov (United States)

    Kudrin, Alex

    2012-10-01

    Despite of growing oncology pipeline, cancer vaccines contribute only to a minor share of total oncology-attributed revenues. This is mainly because of a limited number of approved products and limited sales from products approved under compassionate or via early access entry in smaller and less developed markets. However revenue contribution from these products is extremely limited and it remains to be established whether developers are breaking even or achieving profitability with existing sales. Cancer vaccine field is well recognized for high development costs and risks, low historical rates of investment return and high probability of failures arising in ventures, partnerships and alliances. The cost of reimbursement for new oncology agents is not universally acceptable to payers limiting the potential for a global expansion, market access and reducing probability of commercial success. In addition, the innovation in cancer immunotherapy is currently focused in small and mid-size biotech companies and academic institutions struggling for investment. Existing R&D innovation models are deemed unsustainable in current "value-for-money" oriented healthcare environment. New business models should be much more open to collaborative, networked and federated styles, which could help to outreach global, markets and increase cost-efficiencies across an entire value chain. Lessons learned from some developing countries and especially from South Korea illustrate that further growth of cancer vaccine industry will depends not only on new business models but also will heavily rely on regional support and initiatives from different bodies, such as governments, payers and regulatory bodies. PMID:22894953

  12. Perspectives of development of thyroid cancers in Belarus

    International Nuclear Information System (INIS)

    This paper gives an overview on the total number if thyroid cancers observed in Belarus after the Chernobyl accident among children, discusses possible sources of the observed increase over expected cases and compares these observations with predictive calculations using different risk coefficients published in the literature. To this purpose exposure estimates of the thyroid are made for children living in three selected areas. Different radioecological, dosimetric and other reasons make it very difficult to obtain reliable dose estimates for these victims, and the use of published risk coefficients for the assessment of future developments of the thyroid cancer incidence rates results in predictions which do not agree too well with the observations

  13. Developing a nanoparticle test for prostate cancer scoring

    Directory of Open Access Journals (Sweden)

    Huo Qun

    2012-03-01

    Full Text Available Abstract Background Over-diagnosis and treatment of prostate cancer has been a major problem in prostate cancer care and management. Currently the most relevant prognostic factor to predict a patient's risk of death due to prostate cancer is the Gleason score of the biopsied tissue samples. However, pathological analysis is subjective, and the Gleason score is only a qualitative estimate of the cancer malignancy. Molecular biomarkers and diagnostic tests that can accurately predict prostate tumor aggressiveness are rather limited. Method We report here for the first time the development of a nanoparticle test that not only can distinguish prostate cancer from normal and benign conditions, but also has the potential to predict the aggressiveness of prostate cancer quantitatively. To conduct the test, a prostate tissue lysate sample is spiked into a blood serum or human IgG solution and the spiked sample is incubated with a citrate-protected gold nanoparticle solution. IgG is known to adsorb to citrate-protected gold nanoparticles to form a "protein corona" on the nanoparticle surface. From this study, we discovered that certain tumor-specific molecules can interact with IgG and change the adsorption behavior of IgG to the gold nanoparticles. This change is reflected in the nanoparticle size of the assay solution and detected by a dynamic light scattering technique. Assay data were analyzed by one-way ANOVA for multiple variant analysis, and using the Student t-test or nonparametric Mann-Whitney U-tests for pairwise analyses. Results An inverse, quantitative correlation of the average nanoparticle size of the assay solution with tumor status and histological diagnostic grading was observed from the nanoparticle test. IgG solutions spiked with prostate tumor tissue exhibit significantly smaller nanoparticle size than the solutions spiked with normal and benign tissues. The higher grade the tumor is, the smaller the nanoparticle size is. The test

  14. Logic Programming and Artificial Neural Networks in Breast Cancer Detection

    OpenAIRE

    Neves, José; Guimarães, Tiago; Gomes, Sabino; Vicente, Henrique; Santos, Mariana; Neves, João; Machado, José; Novais, Paulo

    2015-01-01

    About 90% of breast cancers do not cause or are capable of producing death if detected at an early stage and treated properly. Indeed, it is still not known a specific cause for the illness. It may be not only a beginning, but also a set of associations that will determine the onset of the disease. Undeniably, there are some factors that seem to be associated with the boosted risk of the malady. Pondering the present study, different breast cancer risk assessment models where considered. It i...

  15. Logic programming and artificial neural networks in breast cancer detection

    OpenAIRE

    Guimarães, T.; Gomes, S.; Vicente, H.; Santos, M. F.; Neves, José; Machado, José Manuel; Novais, Paulo

    2015-01-01

    About 90% of breast cancers do not cause or are capable of producing death if detected at an early stage and treated properly. Indeed, it is still not known a specific cause for the illness. It may be not only a beginning, but also a set of associations that will determine the onset of the disease. Undeniably, there are some factors that seem to be associated with the boosted risk of the malady. Pondering the present study, different breast cancer risk assessment models where considered. It i...

  16. Radiotherapy for cancer treatment: A growing priority for developing countries

    International Nuclear Information System (INIS)

    During the 50s Costa Rica started an intensive program of primary health care, because infectious diseases such as diarrhea, parasitosis, tuberculosis and malaria were the main cause of mortality among the population. At that time, the infant mortality rate was 90.2 per 100 live births. Investment in primary care demanded huge economic resources, especially in infrastructure. In 1964, the National Children's Hospital was dedicated. This medical center modified the hospital concept of Costa Rica's pioneers in social security. It joined the existing centers: the San Juan de Dios Hospital (1845) and the Dr. Rafael Angel Calderon Guardia Hospital (1943). In, 1969 the newest national hospital, the Mexico Hospital, was built. The epidemiological profile completely changed: the infant mortality rate dropped, life expectancy at birth increased, and many infectious and parasitic diseases were eliminated. However, there was at the same time an increase in degenerative and cardiovascular diseases, and in cancer. It was not until the 70s, 30 years after the first effort to fight cancer began, that the first cobalt teletherapy unit was purchased to assist cancer patients. This unit was a THERATRON 80, installed at the Mexico Hospital shortly after its opening. In 1975, a campaign to purchase a second cobalt unit was organized. The so-called 'March of One Colon-coin' consisted of voluntarily contributing $0.05 per person. At the end, the goal was reached and the unit was installed at the San Juan de Dios Hospital, in the capital city. With these two cobalt units, plus a third one donated in 1992, Costa Rica was poised to address the radiotherapy needs of its 2 million inhabitants. However, in 1995 a team of physicians of the Calderon Guardia Hospital noted with great concern that despite earlier efforts, mortality associated with the five most frequent cancer types had not decreased. A study of cancer incidence in the country was started. However, just as the study was beginning

  17. Center Independent Research & Developments: JSC IRAD Program

    Data.gov (United States)

    National Aeronautics and Space Administration — JSC provides and applies its preeminent capabilities in science and technology to develop, operate, and integrate human exploration missions.  The center...

  18. DSN RFI susceptibility models development program overview

    Science.gov (United States)

    Sue, M. K.

    1982-01-01

    The RFI model development described intended to provide an understanding of the interference susceptibility of DSN receivers. An overview of interference types and effects, analytic modelling and experimental verification is presented.

  19. High burnup fuel development program in Japan

    International Nuclear Information System (INIS)

    A step wise burnup extension program has been progressing in Japan to reduce the LWR fuel cycle cost. At present, the maximum assembly burnup limit of BWR 8 Χ 8 type fuel (B. Step II fuel) is 50GWd/t and a limited numbers of 9 Χ 9 type fuel (B. Step III fuel) with 55GWd/t maximum assembly burnup has been licensed by regulatory agencies recently. Though present maximum assembly burnup limit for PWR fuel is 48GWd/t (P. Step I fuel), the licensing work has been progressing for irradiation testing on a limited number of fuel assemblies with extended burnup of up to 55GWd/t (p. Step II fuel) Design of high burnup fuel and fabrication test are carried out by vendors, and subsequent irradiation test of fuel rods is conducted jointly by utilities and vendors to prepare for licensing. It is usual to make an irradiation test for vectarion, using lead use assemblies by government to confirm fuel integrity and reliability and win the public confidence. Nuclear Power Engineering Corporation (NUPE C) is responsible for verification test. The fuel are subjected to post irradiation examination (PIE) and no unfavorable indications of fuel behavior have found both in NUPE C verification test and joint irradiation test by utilities and vendors. Burnup extension is an urgent task for LWR fuel in Japan in order to establish the domestic fuel cycle. It is conducted in joint efforts of industries, government and institutes. However, watching a situation of burnup extension in the world, we are not going ahead of other countries in the achievement of burnup extension. It is due to a conservative policy in the nuclear safety of the country. This is the reason why the burnup extension program in Japan is progressing 'slow and steady' As for the data obtained, no unfavorable indications of fuel behavior have found both in NUPE C verification test and joint irradiation test by utilities and vendors until now

  20. [Formula: see text]Cognitive training programs for childhood cancer patients and survivors: A critical review and future directions.

    Science.gov (United States)

    Olson, Katie; Sands, Stephen A

    2016-01-01

    A robust literature has developed documenting neurocognitive late effects in survivors of leukemia and central nervous system (CNS) tumors, the most frequent cancer diagnoses of childhood. Patterns of late effects include deficits in attention and concentration, working memory, processing speed, and executive function, as well as other domains. As childhood cancer survivors are living longer, ameliorating deficits both in broad and specific neurocognitive domains has been increasingly recognized as an endeavor of paramount importance. Interventions to improve cognitive functioning were first applied to the field of pediatric oncology in the 1990s, based on strategies used effectively with adults who had sustained a traumatic brain injury (TBI). Compilation and modification of these techniques has led to the development of structured cognitive training programs, with the effectiveness and feasibility of such interventions currently an active area of research. Consequently, the purpose of this critical review is to: (1) review cognitive training programs intended to remediate or prevent neurocognitive deficits in pediatric cancer patients and survivors, (2) critically analyze training program strengths and weaknesses to inform practice, and (3) provide recommendations for future directions of clinical care and research. PMID:26070928

  1. Development and Validation of a Prediction Model to Estimate Individual Risk of Pancreatic Cancer

    OpenAIRE

    Yu, Ami; Woo, Sang Myung; Joo, Jungnam; Yang, Hye-Ryung; Lee, Woo Jin; Park, Sang-Jae; Nam, Byung-Ho

    2016-01-01

    Introduction There is no reliable screening tool to identify people with high risk of developing pancreatic cancer even though pancreatic cancer represents the fifth-leading cause of cancer-related death in Korea. The goal of this study was to develop an individualized risk prediction model that can be used to screen for asymptomatic pancreatic cancer in Korean men and women. Materials and Methods Gender-specific risk prediction models for pancreatic cancer were developed using the Cox propor...

  2. Empirical Studies of Agile Software Development to Learn Programming Skills

    Directory of Open Access Journals (Sweden)

    Yasuyo Kofune

    2014-06-01

    Full Text Available This paper presents a programming education support method based on Agile Development that encourages and builds on communication between students. Through mutual discussion, students using our approach transform their ideas into software and cooperate to write a program. The students complete the software through repetition and programming. Before completing the software program, the students learn to solve problems by working together. The students are encouraged to think and share ideas, and gain experience writing software. With this approach, students not only learn how to write programs, but also increase their logical thinking, problem-solving, and communication skills.

  3. Developing the strategic plan for pollution prevention in defense programs

    International Nuclear Information System (INIS)

    In order to provide effective leadership and to ensure a consistent pollution prevention effort in all of its production facilities and laboratories, Defense Programs (DP) Headquarters, in close cooperation with the Field, has developed a strategic plan for its Pollution Prevention Program. The strategic plan is built upon the history of waste minimization, waste reduction, and pollution prevention activity to date, and articulates both long- and short-term strategies to ensure program initiation, growth, and stability. The organization of the program, including Headquarters staffing and linkages to the Geld, is described. Life-cycle analysis of program barriers and bottlenecks, along with associated initiatives and action plans are discussed. (author)

  4. Functional health literacy in Spanish-speaking Latinas seeking breast cancer screening through the National Breast and Cervical Cancer Screening Program

    OpenAIRE

    Samantha Garbers; Karen Schmitt; Anne Marie Rappa; Mary Ann Chiasson

    2010-01-01

    Samantha Garbers1, Karen Schmitt2, Anne Marie Rappa2, Mary Ann Chiasson11Public Health Solutions, New York, NY, USA; 2Columbia University Breast Cancer Screening Program, New York, NY, USABackground: This analysis examines the association between functional health literacy and follow-up after mammography among women receiving breast cancer screening at a National Breast and Cervical Cancer Early Detection Program site in New York City that provides universal bilingual case management.Methods:...

  5. Employers' role in cancer prevention and treatment-developing success metrics for use by the CEO Roundtable on Cancer.

    Science.gov (United States)

    Henke, Rachel; Goetzel, Ron Z; McHugh, Janice; Gorhan, Deborah; Reynolds, Malinda; Davenport, Jaclyn; Rasmussen, Kate; Isaac, Fikry

    2013-10-01

    As evidence accumulates on the risk factors for cancer, it is becoming clearer that employers can play a significant role in the fight against the disease by creating a workplace conducive to lowering health risks. The CEO Roundtable on Cancer's CEO Cancer Gold Standard Program defines what companies can do to prevent cancer, detect it early, and ensure access to the best available treatments for those who are afflicted with the disease. This article describes how Johnson & Johnson incorporated the Cancer Gold Standard Program into its existing health promotion initiatives. Then, a framework is proposed that employers can use to monitor progress in cancer prevention and treatment enhancement efforts. Finally, health care eligibility, claims, and health risk assessment data are analyzed to quantify Johnson & Johnson's progress since implementation of the Cancer Gold Standard Program. Companies interested in initiating or furthering their health promotion efforts should consider joining groups such as the CEO Cancer Gold Standard. Collectively, companies have the ability to influence policy makers, payers, and the industry at large in changing behaviors and creating a culture of health and wellness in the fight against cancer. PMID:23672234

  6. Cancer Development, Progression, and Therapy: An Epigenetic Overview

    Directory of Open Access Journals (Sweden)

    McKenna Longacre

    2013-10-01

    Full Text Available Carcinogenesis involves uncontrolled cell growth, which follows the activation of oncogenes and/or the deactivation of tumor suppression genes. Metastasis requires down-regulation of cell adhesion receptors necessary for tissue-specific, cell–cell attachment, as well as up-regulation of receptors that enhance cell motility. Epigenetic changes, including histone modifications, DNA methylation, and DNA hydroxymethylation, can modify these characteristics. Targets for these epigenetic changes include signaling pathways that regulate apoptosis and autophagy, as well as microRNA. We propose that predisposed normal cells convert to cancer progenitor cells that, after growing, undergo an epithelial-mesenchymal transition. This process, which is partially under epigenetic control, can create a metastatic form of both progenitor and full-fledged cancer cells, after which metastasis to a distant location may occur. Identification of epigenetic regulatory mechanisms has provided potential therapeutic avenues. In particular, epigenetic drugs appear to potentiate the action of traditional therapeutics, often by demethylating and re-expressing tumor suppressor genes to inhibit tumorigenesis. Epigenetic drugs may inhibit both the formation and growth of cancer progenitor cells, thus reducing the recurrence of cancer. Adopting epigenetic alteration as a new hallmark of cancer is a logical and necessary step that will further encourage the development of novel epigenetic biomarkers and therapeutics.

  7. Follow-up of abnormal or inadequate test results in the Danish Cervical Cancer Screening Program

    DEFF Research Database (Denmark)

    Kristiansen, Bettina Kjær

    2014-01-01

    -up recommendation. However problems with delayed follow-up may threaten the effectiveness of the Danish Cervical Cancer Screening Program, as 20% of women are delayed and dysplasia potentially can progress into cancer. Delayed follow-up is found in situations where women either consciously or unconsciously postpone......Denmark has a higher incidence of cervical cancer than other Nordic countries, although all Danish women (aged 23–65) are screened regularly to identify possible cervical dysplasia or asymptomatic invasive cancer. Annually 40 000 women receives an abnormal or inadequate test result and a follow...... follow-up, or because of organizational aspects of the screening program, where communication regarding test results can fail either in content or with delay.This study will evaluate two interventions designed to increase follow-up: 1) A letter with the test result and potential recommendation for follow...

  8. Validity of fecal occult blood test in the national cancer screening program, Korea.

    Directory of Open Access Journals (Sweden)

    Aesun Shin

    Full Text Available AIM: The aims of the current study were to assess the validity of the fecal occult blood test (FOBT in an organized screening setting in Korea and to determine factors associated with FOBT validity, such as screening round, age group, and anatomical location of the cancer. METHODS: Study participants were those who were 50 years and older who received an FOBT through the National Cancer Screening Program between 2004 and 2007. Colorectal cancer diagnoses were ascertained through linkage with the Korean National Cancer Incidence Database. The positivity rate, colorectal cancer detection rate, interval cancer rate, sensitivity, specificity, and positive predictive value of the FOBT were calculated. RESULTS: A total of 2,193,093 tests were included in the analysis. Overall, the sensitivity of the FOBT for colorectal cancer was 59.7% for the first round and 56.1% for the subsequent round. Sensitivity was highest for distal colon cancer (65.9% in the first round, and for rectal cancer (58.4% for the subsequent round. The sensitivity and positive predictive value of the FOBT generally improved between 2004 and 2008. CONCLUSIONS: The FOBT showed reasonable validity in an organized screening setting, and the validity of the FOBT varied by screening round, anatomical location, and screening year.

  9. Advanced Emissions Control Development Program: Mercury Control

    International Nuclear Information System (INIS)

    McDermott Technology, Inc. (a subsidiary of Babcock ampersand Wilcox) is conducting the Advanced Emissions Control Development Project (AECDP) which is aimed at the development of practical, cost-effective strategies for reducing the emissions of hazardous air pollutants (HAPS) from coal-fired electric utility plants. The need for such controls may arise as the US Environmental Protection Agency (EPA) proceeds with implementation of requirements set forth in the Clean Air Act Amendments (CAAA's) of 1990. Promulgation of air toxics emissions regulations for electric utility plants could dramatically impact utilities burning coal, their industrial and residential customers, and the coal industry. AECDP project work will supply the information needed by utilities to respond to potential HAPs regulations in a timely, cost-effective, enviromnentally-sound manner which supports the continued use of the Nation's abundant reserves of coal, such as those in the State of Ohio. The development work is being carried out using the 10 MW Clean Environment Development Facility wherein air toxics emissions control strategies can be developed under controlled conditions. The specific objectives of the project are to (1) measure and understand production and partitioning of air toxics species for a variety of coals, (2) optimize the air toxics removal performance of conventional flue gas cleanup systems, (3) develop advanced air toxics emissions control concepts, (4) develop and validate air toxics emissions measurement and monitoring techniques, and (5) establish a comprehensive, self-consistent air toxics data library. This project is supported by the Department of Energy, the Ohio Coal Development Office within the Ohio Department of Development and Babcock ampersand Wilcox. A comprehensive assessment of HAP emissions from coal-fired electric utility boilers sponsored by the Department of Energy and the Electric Power Research Institute concluded that with the exception of

  10. The Development of a Physician Vitality Program: A Brief Report.

    Science.gov (United States)

    Hernandez, Barbara Couden; Thomas, Tamara L

    2015-10-01

    We describe the development of an innovative program to support physician vitality. We provide the context and process of program delivery which includes a number of experimental support programs. We discuss a model for intervention and methods used to enhance physician resilience, support work-life balance, and change the culture to one that explicitly addresses the physician's biopsychosocial-spiritual needs. Recommendations are given for marriage and family therapists (MFTs) who wish to develop similar support programs for healthcare providers. Video Abstract. PMID:25109396

  11. Development of Education and Training Programs Using ISIS Research Reactor

    International Nuclear Information System (INIS)

    As a part of the French Alternative Energies and Atomic Energy Commission (CEA), the National Institute for Nuclear Science and Technology (INSTN) carries out various education and training programs on nuclear reactor theory and operation. These programs take advantage of the use of an extensive range of training tools that includes software applications, simulators, as well as the use of research reactors. After a presentation of ISIS reactor, we present the training courses that have been developed on ISIS reactor and their use in education and training programs developed by INSTN. We report on how the training courses carried out on ISIS research reactor ensure a practical and comprehensive understanding of the reactor principle and operation, bringing tremendous benefit to the trainees. We also discuss the future development of education and training programs using the ISIS research reactor as a very powerful tool for the development of the human resources needed by the nuclear industry and the nuclear programs. (author)

  12. Development of a Multidisciplinary, Multicampus Subspecialty Practice in Endocrine Cancers

    Science.gov (United States)

    Bible, Keith C.; Smallridge, Robert C.; Morris, John C.; Molina, Julian R.; Suman, Vera J.; Copland, John A.; Rubin, Joseph; Menefee, Michael E.; Sideras, Kostandinos; Maples, William J.; McIver, Bryan; Fatourechi, Vahab; Hay, Ian; Foote, Robert L.; Garces, Yolanda I.; Kasperbauer, Jan L.; Thompson, Geoffrey B.; Grant, Clive S.; Richards, Melanie L.; Sebo, Thomas; Lloyd, Ricardo; Eberhardt, Norman L.; Reddi, Honey V.; Casler, John D.; Karlin, Nina J.; Westphal, Sydney A.; Richardson, Ronald L.; Buckner, Jan C.; Erlichman, Charles

    2012-01-01

    Purpose: Relative to more abundant neoplasms, endocrine cancers have been historically neglected, yet their incidence is increasing. We therefore sought to build interest in endocrine cancers, improve physician experience, and develop innovative approaches to treating patients with these neoplasms. Methods: Between 2005 and 2010, we developed a multidisciplinary Endocrine Malignancies Disease Oriented Group involving all three Mayo Clinic campuses (Rochester, MN; Jacksonville, FL; and Scottsdale, AZ). In response to higher demand at the Rochester campus, we sought to develop a Subspecialty Tumor Group and an Endocrine Malignancies Tumor Clinic within the Division of Medical Oncology. Results: The intended groups were successfully formed. We experienced difficulty in integration of the Mayo Scottsdale campus resulting from local uncertainty as to whether patient volumes would be sufficient to sustain the effort at that campus and difficulty in developing enthusiasm among clinicians otherwise engaged in a busy clinical practice. But these obstacles were ultimately overcome. In addition, with respect to the newly formed medical oncology subspecialty endocrine malignancies group, appointment volumes quadrupled within the first year and increased seven times within two years. The number of active therapeutic endocrine malignancies clinical trials also increased from one in 2005 to five in 2009, with all three Mayo campuses participating. Conclusion: The development of subspecialty tumor groups for uncommon malignancies represents an effective approach to building experience, increasing patient volumes and referrals, and fostering development of increased therapeutic options and clinical trials for patients afflicted with otherwise historically neglected cancers. PMID:22942830

  13. Cancer screening: Should cancer screening be essential component of primary health care in developing countries?

    Directory of Open Access Journals (Sweden)

    Saurabh Bobdey

    2015-01-01

    Conclusions: Our study highlights the availability and success of visual screening tools in early detection and mortality reduction of major neoplasia in resource-poor health care settings and recommends implementation of oral and cervical cancer screening as part of assured primary health care package in developing countries.

  14. Comprehensive evaluation of cervical cancer screening programs: the case of Colombia

    OpenAIRE

    Raúl Murillo; Carolina Wiesner; Ricardo Cendales; Marion Piñeros; Sandra Tovar

    2011-01-01

    OBJECTIVE: To identify critical screening program factors for reducing cervical cancer mortality in Colombia. MATERIAL AND METHODS: Coverage, quality, and screening follow-up were evaluated in four Colombian states with different mortality rates. A case-control study (invasive cancer and healthy controls) evaluating screening history was performed. RESULTS: 3-year cytology coverage was 72.7%, false negative rate 49%, positive cytology follow-up 64.2%. There was no association between screenin...

  15. Proteomic Serum Biomarkers and Their Potential Application in Cancer Screening Programs

    OpenAIRE

    Deelder, André M; Tollenaar, Rob A. E. M.; Mertens, Bart J.; Yuri E. M. van der Burgt; Anouck Huijbers; Tim J. A. Dekker; Wilma E. Mesker; Berit Velstra

    2010-01-01

    Early diagnosis of cancer is of pivotal importance to reduce disease-related mortality. There is great need for non-invasive screening methods, yet current screening protocols have limited sensitivity and specificity. The use of serum biomarkers to discriminate cancer patients from healthy persons might be a tool to improve screening programs. Mass spectrometry based proteomics is widely applied as a technology for mapping and identifying peptides and proteins in body fluids. One commonly use...

  16. Readiness of primary care clinicians to implement lung cancer screening programs

    OpenAIRE

    Volk, Robert J.; Lewis E. Foxhall

    2015-01-01

    We examined the readiness of primary care clinicians to implement lung cancer screening programs in their practice settings in light of recent policy changes in the U.S. Attendees of two large continuing medical education events in Texas held in October and November of 2014 completed surveys about their current lung cancer screening practices and implementation needs. Surveys were completed by 350 participants (57.2% of registered attendees). Although 89.5% of participants routinely scr...

  17. Community cancer programs as strategic alliances: challenges and guidelines for action.

    OpenAIRE

    Kaluzny, A D

    1991-01-01

    This paper assesses the utility of strategic alliances as a way of expanding and improving the quality of cancer care provided in communities with limited access to major treatment centres. Alliances provide an organizational model for future community-based cancer programs by accommodating a growing need for interdependence among organizations and providers while permitting substantial independence and autonomy. Five managerial challenges to ensuring effective and efficient delivery of cance...

  18. Law 16.097 Prevention program of uterine cervix cancer in Uruguay: Uterine cervix cancer

    International Nuclear Information System (INIS)

    Every year in Uruguay, is diagnosed around 600 new cases of cancer of uterine cervix. Next important information was related on this cancer and the evolution that will have the carrying of this illness, it was informed about the prevention, symptoms, I diagnose and treatment of the same one

  19. Colorectal cancer early detection program integrated in practice of family physicians

    Directory of Open Access Journals (Sweden)

    Sanda Pribić

    2011-02-01

    Full Text Available Aim To present preliminary results of the colorectal cancer earlydetection program, a part of the project called „A Model of EarlyCancer Detection Integrated in a Practice of a Family Physician“,carried out by the Department of Family Medicine of the OsijekUniversity School of Medicine and the Health Centre of Osijek,Croatia. Methods The strategy of the project, based on the central role of a family physician in the implementation of the early cancer detection programs, was described and preliminary results of the colorectal cancer early detection program are presented and comparedwith the same issues of the National Program, centrally conductedand supplied by public services. Results From the beginning of April unil the end of May 2009, a total number of 516 testing cards on occult faecal blood were delivered to patients from two target groups (aged 45-50 and 75-79. A high responding rate of 69,76% (360 was recorded. This is an advantage in comparison with the low responding rates of about 20% (43 862, obtained by the National Program. In the project, there were in average 2,5% (9 positive tests, with the higher percent in the older than in the younger age group, 3,5% (12 and 1% (4 respectively. Conclusion Data obtained by the Project, and by the National Program - indicate that there could be a need for a more precise definition of risk groups who have to be invited for screening.

  20. Motor Development Programming in Trisomic-21 Babies

    Science.gov (United States)

    Sanz, Teresa; Menendez, Javier; Rosique, Teresa

    2011-01-01

    The present study contributes to the understanding of gross motor development in babies with Down's syndrome. Also, it facilitates the comprehension of the efficiency of the early motor stimulation as well as of beginning it as early as possible. We worked with two groups of babies with Down's syndrome, beginning the early motor training in each…

  1. Next Generation Drivetrain Development and Test Program

    Energy Technology Data Exchange (ETDEWEB)

    Keller, Jonathan; Erdman, Bill; Blodgett, Doug; Halse, Chris; Grider, Dave

    2015-11-03

    This presentation was given at the Wind Energy IQ conference in Bremen, Germany, November 30 through December 2, 2105. It focused on the next-generation drivetrain architecture and drivetrain technology development and testing (including gearbox and inverter software and medium-voltage inverter modules.

  2. Development of simulation curriculum in postgraduate programs

    Directory of Open Access Journals (Sweden)

    Hani Lababidi

    2015-01-01

    Full Text Available This paper outlines the primary steps required in developing a simulation curriculum. We examine forms of simulation in postgraduate training, instructional design models, learner assessment, and modular pattern of postgraduate simulation curriculum. Further, we provide examples of how each of these components are practically described in the literature and applied at the Center for Research, Education, and Simulation-Enhanced Training.

  3. Implementing sustainable development programs in Chicago

    Energy Technology Data Exchange (ETDEWEB)

    Henderson, H.

    1994-12-31

    Achieving sustainable development requires a revision of the present view of the nature of the city as an environment, and its relation to a larger ecosystem of which it is an essential part. The environmental health of a wilderness area is inextricably related to the environmental, and economic, health of the great urban centers. The vitality of dense metropolitan areas, where population and economic activities are concentrated, is key to the preservation of productive farm lands, wildlife habitat, and open spaces. The social and economic crisis which grips many metropolitan centers, with attendant flight of industry and development to the so-called {open_quotes}greenfields,{close_quotes} fundamentally spreads a broader crisis to our common ecosystem. This crisis is marked by the obliteration of habitat necessary for biodiversity, loss of fertile farm land, and the contamination of air, water and land, as an unescapable effect of the sprawl created by flight from the urban centers. The removal of false conceptual distinctions between the city and nature, distinctions that are unfortunately at the heart of so much of American environmental philosophy, is key to the concept of `sustainable development.` This article sets forth how the City of Chicago is implementing this understanding of the nature of the urban environment, in pursuit of sustainable development within the city.

  4. Effective Software Engineering Leadership for Development Programs

    Science.gov (United States)

    Cagle West, Marsha

    2010-01-01

    Software is a critical component of systems ranging from simple consumer appliances to complex health, nuclear, and flight control systems. The development of quality, reliable, and effective software solutions requires the incorporation of effective software engineering processes and leadership. Processes, approaches, and methodologies for…

  5. Energy development and nuclear program in China

    International Nuclear Information System (INIS)

    In this paper the current situation of energy consumption in China is provided. Coal-burn as a dominant sector of energy consumption causes heavy burden on transportation and serious environmental pollution. The roles of nuclear energy in the future energy supply are discussed. The situation of nuclear development, especially heating reactor is introduced. (author)

  6. Implementing sustainable development programs in Chicago

    International Nuclear Information System (INIS)

    Achieving sustainable development requires a revision of the present view of the nature of the city as an environment, and its relation to a larger ecosystem of which it is an essential part. The environmental health of a wilderness area is inextricably related to the environmental, and economic, health of the great urban centers. The vitality of dense metropolitan areas, where population and economic activities are concentrated, is key to the preservation of productive farm lands, wildlife habitat, and open spaces. The social and economic crisis which grips many metropolitan centers, with attendant flight of industry and development to the so-called open-quotes greenfields,close quotes fundamentally spreads a broader crisis to our common ecosystem. This crisis is marked by the obliteration of habitat necessary for biodiversity, loss of fertile farm land, and the contamination of air, water and land, as an unescapable effect of the sprawl created by flight from the urban centers. The removal of false conceptual distinctions between the city and nature, distinctions that are unfortunately at the heart of so much of American environmental philosophy, is key to the concept of 'sustainable development.' This article sets forth how the City of Chicago is implementing this understanding of the nature of the urban environment, in pursuit of sustainable development within the city

  7. Developing and Implementing a Counselor Evaluation Program.

    Science.gov (United States)

    Bell, Priscilla J.; Acker, Kathleen E.

    In the past several years, Tacoma Community College (TCC) has devoted increasing attention to evaluating faculty and staff performance. In recognition of the benefits of a growth-oriented evaluation process over a summative evaluation, the counselors and the Dean for Student Services at TCC developed a comprehensive evaluation system for…

  8. Tools for Nanotechnology Education Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Dorothy Moore

    2010-09-27

    The overall focus of this project was the development of reusable, cost-effective educational modules for use with the table top scanning electron microscope (TTSEM). The goal of this project's outreach component was to increase students' exposure to the science and technology of nanoscience.

  9. ALS liquid hydrogen turbopump: Advanced Development Program

    Science.gov (United States)

    Shimp, Nancy R.; Claffy, George J.

    1989-01-01

    The point of departure (POD) turbopump concept was reviewed and finalized. The basis for the POD was the configuration presented in the Aerojet proposal. After reviewing this proposal concept, several modifications were made. These modifications include the following: (1) the dual pump discharge arrangement was changed to a single discharge; (2) commonality of the turbine inlet manifold with the advanced launch system (ALS) liquid oxygen (LOX) TPA was dropped for this program; (3) the turbine housing flange arrangement was improved by relocating it away from the first stage nozzles; (4) a ten percent margin (five percent diameter increase) was built into the impeller design to ensure meeting the required discharge pressure without the need for increasing speed; (5) a ten percent turbine power margin was imposed which is to be obtained by increasing turbine inlet pressure if required; and (6) the backup concept, as an alternative to the use of cast impellers, now incorporates forged/machined shrouded impellers, rather than the unshrouded type originally planned.

  10. Breast cancer correlates in a cohort of breast screening program participants in Riyadh, KSA

    International Nuclear Information System (INIS)

    Background: Breast cancer is the first cancer among females in the Kingdom of Saudi Arabia, accounting for 27.4% of all newly diagnosed female cancers in 2010. There are several risk factors affecting the incidence of breast cancer where some factors influence the risk more than the others. Aim: We aimed to identify the different risk factors related to breast cancer among females participating in the breast-screening program in Riyadh, KSA. Methods: Based on data from phase-I of the breast-screening program, a case-control study was conducted on women living in Riyadh, KSA. A sample of 349 women (58 cases and 290 controls) was recruited to examine the different breast cancer correlates. Multivariate regression model was built to investigate the most important risk factors. Results: The mean age of cases was 48.5 ± 7.1 years. Age at marriage, number of pregnancy, age at menopause, oral contraceptive pills, breast feeding and family history of breast cancer in first-degree relative were identified as the most important correlates among the studied cohort. Conclusions: The findings of the current work suggested that age at marriage, age at menopause ≥50 years, and 1st degree family history of breast cancer were risk factors for breast cancer, while, age at menopause<50 years, number of pregnancies and practicing breast feeding were protective factors against breast cancer. There was no effect of body mass index or physical inactivity. Further studies are needed to explore the hereditary, familial and genetic background risk factors in Saudi population.

  11. Laboratory Directed Research and Development Program FY 2006 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Sjoreen, Terrence P [ORNL

    2007-04-01

    The Oak Ridge National Laboratory (ORNL) Laboratory Directed Research and Development (LDRD) Program reports its status to the US Departmental of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, 'Laboratory Directed Research and Development' (April 19, 2006), which establishes DOE's requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries all ORNL LDRD research activities supported during FY 2006. The associated FY 2006 ORNL LDRD Self-Assessment (ORNL/PPA-2007/2) provides financial data about the FY 2006 projects and an internal evaluation of the program's management process.

  12. Collaborative development of Estonian nuclear master's program

    International Nuclear Information System (INIS)

    In 2009 Estonia approved the National Development Plan for the Energy Sector, including the nuclear energy option. This can be realized by construction of a nuclear power plant (NPP) in Estonia or by participation in neighboring nuclear projects (e.g., Lithuania and/or Finland). Either option requires the availability of competent personnel. It is necessary to prepare specialists with expertise in all aspects related to nuclear infrastructure and to meet workforce needs (e.g. energy enterprises, public agencies, municipalities). Estonia's leading institutions of higher education and research with the support of the European Social Fund have announced in this context a new nuclear master's curriculum to be developed. The language of instruction will be English. (authors)

  13. [Cancer].

    Science.gov (United States)

    de la Peña-López, Roberto; Remolina-Bonilla, Yuly Andrea

    2016-09-01

    Cancer is a group of diseases which represents a significant public health problem in Mexico and worldwide. In Mexico neoplasms are the second leading cause of death. An increased morbidity and mortality are expected in the next decades. Several preventable risk factors for cancer development have been identified, the most relevant including tobacco use, which accounts for 30% of the cancer cases; and obesity, associated to another 30%. These factors, in turn, are related to sedentarism, alcohol abuse and imbalanced diets. Some agents are well knokn to cause cancer such as ionizing radiation, viruses such as the papilloma virus (HPV) and hepatitis virus (B and C), and more recently environmental pollution exposure and red meat consumption have been pointed out as carcinogens by the International Agency for Research in Cancer (IARC). The scientific evidence currently available is insufficient to consider milk either as a risk factor or protective factor against different types of cancer. PMID:27603890

  14. Superconducting magnet research and development program

    International Nuclear Information System (INIS)

    Viewgraphs for the conference presentation are given. The author reports technical progress in the research and development of cable-in-conduit internally-cooled superconductors; the design, construction and test of EBT-P magnets; the tests of Westinghouse/Airco Nb3Sn conductors; partial-array test in IFSMTF; the evaluation of pressure taps on the Westinghouse conductor sheath; and IFSMTF vapor-cooled-lead tests. 12 figs., 1 tab

  15. Developing a Training Program for Collection Managers

    OpenAIRE

    Forte, Eric; Chiu, Cathy; Barnes, Sherri; DeDecker, Sherry; Colmenar, Gary; Pickett, Carmelita; Lewis, Sandy; Johns, Cecily

    2002-01-01

    Training new collection managers (bibliographers) in an academic research library is an enduring challenge, especially in the modern collections environment. Many bibliographers come to the job with limited subject expertise, and must also master a constantly evolving collection development environment featuring interdisciplinary collecting, aggressive cooperative purchasing, and a myriad of technological issues.  This paper examines collection manager training at UC Santa Barbara.  It descri...

  16. NIH Roadmap & the Common Fund - Cancer Imaging Program

    Science.gov (United States)

    The NIH Roadmap for Medical Research is a series of high impact, trans-NIH programs supported by the NIH Common Fund. These programs address challenges that are priorities for the NIH and medical research but are issues that require the cooperation of more than one NIH institute to address.

  17. Environmental Development Plan (EDP). Magnetic fusion program

    International Nuclear Information System (INIS)

    The Environmental Development Plan (EDP) for magnetic fusion briefly describes the present status of this energy technology and identifies potential areas of concern relevant to the health and safety of workers, the general public, and the natural and man-made environment. It also addresses socioeconomic implications. This plan identifies research and development needed to solve anticipated problems in a timely fashion so that design and operational decisions can be made with reasonably relevant data on which to base such decisions. The principal Environmental Health and Safety (EH and S) concern is radiation exposure resulting directly and indirectly from the deuterium-tritium fusion reaction to be used in early fusion devices. Potentials for personnel and environmental exposure to tritium and neutron-activated materials necessitate special consideration in the selection of materials and development of techniques to minimize escape of radioactivity and ameliorate the consequences of contamination events. The potential for accidents is reviewed in some detail. The presence of magnetic fields up to several hundred Gauss in occupied areas of magnetic fusion reactors raises the question of possible health consequences. Magnetic fusion reactors may require large amounts of special materials whose price and availability must be considered. This EDP addresses only EH and S issues relevant to first generation, pure fusion, central electric power stations for commercial applications. It does not consider possible alternate, nonelectrical applications or fusion-fission hybrids

  18. Forschungszentrum Karlsruhe Technik und Umwelt. Research and development program 2002

    International Nuclear Information System (INIS)

    The five main fields of research and the activities under the R and D program 2002 are explained in great detail in five chapters with the following captions: 1. ENVIRONMENT. Programs: - Sustainable development, energy and environmental engineering (UMWELT). - Earth atmosphere and climate research (ATMO). 2. PUBLIC HEALTH. Programs: - Biomedical research (BIOMED). - Medical engineering (MEDTECH). 3. ENERGY. Programs: - Thermonuclear fusion (FUSION). - Nuclear safety (NUKLEAR). 4. KEY TECHNOLOGIES. Programs: - Microsystems engineering (MIKRO). - Nanotechnology (NANO). - Materials science (MATERIAL). - Chemical process engineering (CHEMIE). - Superconductivity (SUPRA). 5. MATTER and STRUCTURE. Program: The structure of matter (STRUKTUR). The sixth chapter presents cross-cutting activities under the program: Technology transfer and marketing (TTM). The concluding chapter lists and briefly presents the activities of the scientific and technical institutes of the Karlsruhe Research Center. (CB)

  19. Development of a conceptual model of cancer caregiver health literacy.

    Science.gov (United States)

    Yuen, E Y N; Dodson, S; Batterham, R W; Knight, T; Chirgwin, J; Livingston, P M

    2016-03-01

    Caregivers play a vital role in caring for people diagnosed with cancer. However, little is understood about caregivers' capacity to find, understand, appraise and use information to improve health outcomes. The study aimed to develop a conceptual model that describes the elements of cancer caregiver health literacy. Six concept mapping workshops were conducted with 13 caregivers, 13 people with cancer and 11 healthcare providers/policymakers. An iterative, mixed methods approach was used to analyse and synthesise workshop data and to generate the conceptual model. Six major themes and 17 subthemes were identified from 279 statements generated by participants during concept mapping workshops. Major themes included: access to information, understanding of information, relationship with healthcare providers, relationship with the care recipient, managing challenges of caregiving and support systems. The study extends conceptualisations of health literacy by identifying factors specific to caregiving within the cancer context. The findings demonstrate that caregiver health literacy is multidimensional, includes a broad range of individual and interpersonal elements, and is influenced by broader healthcare system and community factors. These results provide guidance for the development of: caregiver health literacy measurement tools; strategies for improving health service delivery, and; interventions to improve caregiver health literacy. PMID:25630765

  20. Programmed Cell Death During Female Gametophyte Development

    Energy Technology Data Exchange (ETDEWEB)

    Drews, Gary, N.

    2004-09-15

    Endosperm is a storage tissue in the angiosperm seed that is important both biologically and agriculturally. Endosperm is biologically important because it provides nutrients to the embryo during seed development and agriculturally important because it is a significant source of food, feed, and industrial raw materials. Approximately two-thirds of human calories are derived from endosperm, either directly or indirectly through animal feed. Furthermore, endosperm is used as a raw material for numerous industrial products including ethanol. A major event in endosperm development is the transition between the syncytial phase, during which the endosperm nuclei undergo many rounds of mitosis without cytokinesis, and the cellularized phase, during which cell walls form around the endosperm nuclei. Understanding how the syncytial-cellular transition is regulated is agriculturally important because it influences seed size, seed sink strength, and grain weight. However, the molecular processes controlling this transition are not understood. This project led to the identification of the AGL62 gene that regulates the syncytial-cellular transition during endosperm development. AGL62 is expressed during the syncytial phase and suppresses endosperm cellularization during this period. AGL62 most likely does so by suppressing the expression of genes required for cellularization. At the end of the syncytial phase, the FIS PcG complex suppresses AGL62 expression, which allows expression of the cellularization genes and triggers the initiation of the cellularized phase. Endosperm arises following fertilization of the central cell within the female gametophyte. This project also led to the identification of the AGL80 gene that is required for development of the central cell into the endosperm. Within the ovule and seed, AGL80 is expressed exclusively in the central cell and uncellularized endosperm. AGL80 is required for expression of several central cell-expressed genes, including

  1. Exercise and nutrition routine improving cancer health (ENRICH: The protocol for a randomized efficacy trial of a nutrition and physical activity program for adult cancer survivors and carers

    Directory of Open Access Journals (Sweden)

    Boyes Allison

    2011-04-01

    Full Text Available Abstract Background The Exercise and Nutrition Routine Improving Cancer Health (ENRICH study is investigating a novel lifestyle intervention aimed at improving the health behaviors of adult cancer survivors and their carers. The main purpose of the study is to determine the efficacy of lifestyle education and skill development delivered via group-based sessions on the physical activity and dietary behaviors of participants. This article describes the intervention development, study design, and participant recruitment. Methods/Design ENRICH is a randomized controlled trial, conducted in Australia, with two arms: an intervention group participating in six, two-hour face-to-face sessions held over eight weeks, and a wait-list control group. Intervention sessions are co-facilitated by an exercise physiologist and dietician. Content includes healthy eating education, and a home-based walking (utilizing a pedometer and resistance training program (utilizing elastic tubing resistance devices. The program was developed with reference to social cognitive theory and chronic disease self-management models. The study population consists of cancer survivors (post active-treatment and their carers recruited through community-based advertising and referral from health professionals. The primary outcome is seven-days of sealed pedometry. Secondary outcomes include: self-reported physical activity levels, dietary intake, sedentary behavior, waist circumference, body mass index, quality of life, and perceived social support. The outcomes will be measured at baseline (one week prior to attending the program, eight-weeks (at completion of intervention sessions, and 20-weeks. The intervention group will also be invited to complete 12-month follow-up data collection. Process evaluation data will be obtained from participants by questionnaire and attendance records. Discussion No trials are yet available that have evaluated the efficacy of group-based lifestyle

  2. MITOCHONDRIA: INSIGHT TARGET OF DRUG DEVELOPMENT IN CANCER CELLS

    Directory of Open Access Journals (Sweden)

    Md. Ataur Rahman

    2012-09-01

    Full Text Available Mitochondria are involved in different physiological and pathological processes that are crucial for tumor cell physiology, growth and survival and its dysfunction leads to many human abnormalities, including cardiovascular diseases, neurodegenerative diseases, autoimmune disorders and cancer. The present review is focused on the different experimental and therapeutic cancer strategies addressed to either target mitochondria directly, or use mitochondria as mediators of apoptosis, although its total molecular mechanism has not been elucidated. Therefore, the role of mitochondria in the etiology and progression of several function and explore potential therapeutic benefits of targeting mitochondria in the disease processes. Newly evolving advances in disease diagnostics and therapy will further facilitate future growth in the field of mitochondrian biology, where there is a dire need for sensitive and more affordable diagnostic tools and an urgency to develop effective therapies and identify reliable drug to predict accurately the response to a cancer therapy. These approaches to treat mitochondrial dysfunction rationally could lead to selective protection of cells in different tissues and various disease states. To avoid mitochondrial liabilities, routine screens need to be positioned within the drug-development process as targets of drug-induced cytotoxicity or cancer promotion, as regulators of apoptosis, as sources of cell signalling through reactive oxygen species, and mitochondrial control of specific nuclear responses. However, several novel mitochondrial targets are now emerging, including the potential to manipulate the mitochondrial pool to maintain function via biogenesis and mitophagy. Forthcoming insights into the fine regulation of mitochondrial apoptosis will likely open future perspectives for cancer drug development.

  3. An Integrated Programming and Development Environment for Adiabatic Quantum Optimization

    OpenAIRE

    Humble, Travis S.; McCaskey, Alex J.; Bennink, Ryan S.; Billings, Jay J.; D'Azevedo, Ed F.; Sullivan, Blair D.; Klymko, Christine F.; Seddiqi, Hadayat

    2013-01-01

    Adiabatic quantum computing is a promising route to the computational power afforded by quantum information processing. The recent availability of adiabatic hardware has raised challenging questions about how to evaluate adiabatic quantum optimization programs. Processor behavior depends on multiple steps to synthesize an adiabatic quantum program, which are each highly tunable. We present an integrated programming and development environment for adiabatic quantum optimization called JADE tha...

  4. Clean coal technologies: Research, development, and demonstration program plan

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-01

    The US Department of Energy, Office of Fossil Energy, has structured an integrated program for research, development, and demonstration of clean coal technologies that will enable the nation to use its plentiful domestic coal resources while meeting environmental quality requirements. The program provides the basis for making coal a low-cost, environmentally sound energy choice for electric power generation and fuels production. These programs are briefly described.

  5. Structural and Reliability Analysis of a Patient Satisfaction with Cancer-Related Care Measure: A Multi-Site Patient Navigation Research Program Study

    Science.gov (United States)

    Jean-Pierre, Pascal; Fiscella, Kevin; Freund, Karen M; Clark, Jack; Darnell, Julie; Holden, Alan; Post, Doug; Patierno, Steven R; Winters, Paul C.

    2010-01-01

    Background Patient satisfaction (PS) is an important outcome measure of quality of cancer care and one of the four core study outcomes of the National Cancer Institute (NCI) sponsored Patient Navigation Research Program (PNRP) to reduce race/ethnicity-based disparities in cancer care. There is no existing PS measure that spans the spectrum of cancer-related care. Objective Develop a Patient Satisfaction with Cancer Care (PSCC) measure that is relevant to patients receiving diagnostic/therapeutic cancer-related care. Methods We developed a conceptual framework, an operational definition of PSCC, and an item pool based on literature review, expert feedback, group discussion and consensus. The 35-item PSCC measure was administered to 891 participants from the multi-site NCI-sponsored PNRP. Principal components analysis (PCA) was conducted for latent structure analysis. Internal consistency was assessed using Cronbach coefficient alpha (α). Divergent analysis was performed using correlation analyses between the PSCC, the Communication and Attitudinal Self-Efficacy (CASE-Cancer), and demographic variables. Results The PCA revealed a one-dimensional measure with items forming a coherent set explaining 62% of the variance in PS. Reliability assessment revealed high internal consistency (α ranging from 0.95 to 0.96). The PSCC demonstrated good face validity, convergent validity and divergent validity as indicated by moderate correlations with subscales of the CASE-Cancer (all ps 0.05). Conclusion The PSCC is a valid tool for assessing satisfaction for cancer-related care for this sample. PMID:20922802

  6. Use of risk projection models to estimate mortality and incidence from radiation-induced breast cancer in screening programs

    International Nuclear Information System (INIS)

    The authors report on a method to calculate radiological risks, applicable to breast screening programs and other controlled medical exposures to ionizing radiation. In particular, it has been applied to make a risk assessment in the Valencian Breast Cancer Early Detection Program (VBCEDP) in Spain. This method is based on a parametric approach, through Markov processes, of hazard functions for radio-induced breast cancer incidence and mortality, with mean glandular breast dose, attained age and age-at-exposure as covariates. Excess relative risk functions of breast cancer mortality have been obtained from two different case-control studies exposed to ionizing radiation, with different follow-up time: the Canadian Fluoroscopy Cohort Study (1950-1987) and the Life Span Study (1950-1985 and 1950-1990), whereas relative risk functions for incidence have been obtained from the Life Span Study (1958-1993), the Massachusetts tuberculosis cohorts (1926-1985 and 1970-1985), the New York post-partum mastitis patients (1930-1981) and the Swedish benign breast disease cohort (1958-1987). Relative risks from these cohorts have been transported to the target population undergoing screening in the Valencian Community, a region in Spain with about four and a half million inhabitants. The SCREENRISK software has been developed to estimate radiological detriments in breast screening. Some hypotheses corresponding to different screening conditions have been considered in order to estimate the total risk associated with a woman who takes part in all screening rounds. In the case of the VBCEDP, the total radio-induced risk probability for fatal breast cancer is in a range between [5 x 10-6, 6 x 10-4] versus the natural rate of dying from breast cancer in the Valencian Community which is 9.2 x 10-3. The results show that these indicators could be included in quality control tests and could be adequate for making comparisons between several screening programs

  7. Use of risk projection models to estimate mortality and incidence from radiation-induced breast cancer in screening programs

    Energy Technology Data Exchange (ETDEWEB)

    Ramos, M [Chemical and Nuclear Engineering Department, Polytechnic University of Valencia, Camino de Vera s/n 46022 Valencia (Spain); Ferrer, S [Chemical and Nuclear Engineering Department, Polytechnic University of Valencia, Camino de Vera s/n 46022 Valencia (Spain); Villaescusa, J I [Radiation Protection Service, Hospital Universitario La Fe, Avda Campanar, 21 46009 Valencia (Spain); Verdu, G [Chemical and Nuclear Engineering Department, Polytechnic University of Valencia, Camino de Vera s/n 46022 Valencia (Spain); Salas, M D [Public Health General Direction, Conselleria de Sanitat de Valencia, C/Micer Masco, 31 46021 Valencia (Spain); Cuevas, M D [Assistential Service General Direction, Conselleria de Sanitat de Valencia, C/Micer Masco, 31 46021 Valencia (Spain)

    2005-02-07

    The authors report on a method to calculate radiological risks, applicable to breast screening programs and other controlled medical exposures to ionizing radiation. In particular, it has been applied to make a risk assessment in the Valencian Breast Cancer Early Detection Program (VBCEDP) in Spain. This method is based on a parametric approach, through Markov processes, of hazard functions for radio-induced breast cancer incidence and mortality, with mean glandular breast dose, attained age and age-at-exposure as covariates. Excess relative risk functions of breast cancer mortality have been obtained from two different case-control studies exposed to ionizing radiation, with different follow-up time: the Canadian Fluoroscopy Cohort Study (1950-1987) and the Life Span Study (1950-1985 and 1950-1990), whereas relative risk functions for incidence have been obtained from the Life Span Study (1958-1993), the Massachusetts tuberculosis cohorts (1926-1985 and 1970-1985), the New York post-partum mastitis patients (1930-1981) and the Swedish benign breast disease cohort (1958-1987). Relative risks from these cohorts have been transported to the target population undergoing screening in the Valencian Community, a region in Spain with about four and a half million inhabitants. The SCREENRISK software has been developed to estimate radiological detriments in breast screening. Some hypotheses corresponding to different screening conditions have been considered in order to estimate the total risk associated with a woman who takes part in all screening rounds. In the case of the VBCEDP, the total radio-induced risk probability for fatal breast cancer is in a range between [5 x 10{sup -6}, 6 x 10{sup -4}] versus the natural rate of dying from breast cancer in the Valencian Community which is 9.2 x 10{sup -3}. The results show that these indicators could be included in quality control tests and could be adequate for making comparisons between several screening programs.

  8. Virtual Weight Loss Program in Maintaining Weight in African American Breast Cancer Survivors

    Science.gov (United States)

    2016-03-01

    Cancer Survivor; Invasive Breast Carcinoma; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage IIA Breast Cancer; Stage IIB Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer

  9. Coal feeder development program. Phase III report

    Energy Technology Data Exchange (ETDEWEB)

    1979-09-01

    As a result of the work carried out in Phases I and II, the Kinetic Extruder was selected for further development during Phase III. Design studies were performed to identify components of the Kinetic Extruder which had an important impact on performance. These components were optimized and subjected to testing in the coal feeder test loop. The improved components were incorporated in the design of the Kinetic Extruder, Model No. 3, which was successfully tested up to 400 psig. The Kinetic Extruder Model No. 4 was designed to incorporate low differential pressure seals and provision for fluidic turndown control. This machine is ready for testing and engineering evaluation.

  10. Fuel rod welding (LWBR development program)

    International Nuclear Information System (INIS)

    Procedures were developed to weld both ends of approximately 25,000 fuel rods for the Light Water Breeder Reactor (LWBR) core. The rods were welded using the gas tungsten arc (GTA) method in high-purity helium at 1 atmosphere. Welding parameters, including weld current, arc gap, and speed of rotation, were established to control the size of the weld. Electrode and chill positioning with respect to the endclosure/tube joint controlled the location of the weld. Weld quality of the fuel rods was ensured by 100-percent nondestructive testing by ultrasonic and radiographic inspection and the destructive evaluation of process control samples in each weld lot

  11. Proteomic Serum Biomarkers and Their Potential Application in Cancer Screening Programs

    Directory of Open Access Journals (Sweden)

    André M. Deelder

    2010-10-01

    Full Text Available Early diagnosis of cancer is of pivotal importance to reduce disease-related mortality. There is great need for non-invasive screening methods, yet current screening protocols have limited sensitivity and specificity. The use of serum biomarkers to discriminate cancer patients from healthy persons might be a tool to improve screening programs. Mass spectrometry based proteomics is widely applied as a technology for mapping and identifying peptides and proteins in body fluids. One commonly used approach in proteomics is peptide and protein profiling. Here, we present an overview of profiling methods that have the potential for implementation in a clinical setting and in national screening programs.

  12. Laboratory Directed Research and Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Ogeka, G.J.; Romano, A.J.

    1992-12-01

    This report briefly discusses the following research: Advances in Geoexploration; Transvenous Coronary Angiography with Synchrotron X-Rays; Borehole Measurements of Global Warming; Molecular Ecology: Development of Field Methods for Microbial Growth Rate and Activity Measurements; A New Malaria Enzyme - A Potential Source for a New Diagnostic Test for Malaria and a Target for a New Antimalarial Drug; Basic Studies on Thoron and Thoron Precursors; Cloning of the cDNA for a Human Serine/Threonine Protein Kinase that is Activated Specifically by Double-Stranded DNA; Development of an Ultra-Fast Laser System for Accelerator Applications; Cluster Impact Fusion; Effect of a Bacterial Spore Protein on Mutagenesis; Structure and Function of Adenovirus Penton Base Protein; High Resolution Fast X-Ray Detector; Coherent Synchrotron Radiation Longitudinal Bunch Shape Monitor; High Grain Harmonic Generation Experiment; BNL Maglev Studies; Structural Investigations of Pt-Based Catalysts; Studies on the Cellular Toxicity of Cocaine and Cocaethylene; Human Melanocyte Transformation; Exploratory Applications of X-Ray Microscopy; Determination of the Higher Ordered Structure of Eukaryotic Chromosomes; Uranium Neutron Capture Therapy; Tunneling Microscopy Studies of Nanoscale Structures; Nuclear Techiques for Study of Biological Channels; RF Sources for Accelerator Physics; Induction and Repair of Double-Strand Breaks in the DNA of Human Lymphocytes; and An EBIS Source of High Charge State Ions up to Uranium.

  13. Laboratory Directed Research and Development Program

    International Nuclear Information System (INIS)

    This report briefly discusses the following research: Advances in Geoexploration; Transvenous Coronary Angiography with Synchrotron X-Rays; Borehole Measurements of Global Warming; Molecular Ecology: Development of Field Methods for Microbial Growth Rate and Activity Measurements; A New Malaria Enzyme - A Potential Source for a New Diagnostic Test for Malaria and a Target for a New Antimalarial Drug; Basic Studies on Thoron and Thoron Precursors; Cloning of the cDNA for a Human Serine/Threonine Protein Kinase that is Activated Specifically by Double-Stranded DNA; Development of an Ultra-Fast Laser System for Accelerator Applications; Cluster Impact Fusion; Effect of a Bacterial Spore Protein on Mutagenesis; Structure and Function of Adenovirus Penton Base Protein; High Resolution Fast X-Ray Detector; Coherent Synchrotron Radiation Longitudinal Bunch Shape Monitor; High Grain Harmonic Generation Experiment; BNL Maglev Studies; Structural Investigations of Pt-Based Catalysts; Studies on the Cellular Toxicity of Cocaine and Cocaethylene; Human Melanocyte Transformation; Exploratory Applications of X-Ray Microscopy; Determination of the Higher Ordered Structure of Eukaryotic Chromosomes; Uranium Neutron Capture Therapy; Tunneling Microscopy Studies of Nanoscale Structures; Nuclear Techiques for Study of Biological Channels; RF Sources for Accelerator Physics; Induction and Repair of Double-Strand Breaks in the DNA of Human Lymphocytes; and An EBIS Source of High Charge State Ions up to Uranium

  14. Analysis of PET hypoxia imaging in the quantitative imaging for personalized cancer medicine program

    International Nuclear Information System (INIS)

    Quantitative imaging is an important tool in clinical trials of testing novel agents and strategies for cancer treatment. The Quantitative Imaging Personalized Cancer Medicine Program (QIPCM) provides clinicians and researchers participating in multi-center clinical trials with a central repository for their imaging data. In addition, a set of tools provide standards of practice (SOP) in end-to-end quality assurance of scanners and image analysis. The four components for data archiving and analysis are the Clinical Trials Patient Database, the Clinical Trials PACS, the data analysis engine(s) and the high-speed networks that connect them. The program provides a suite of software which is able to perform RECIST, dynamic MRI, CT and PET analysis. The imaging data can be assessed securely from remote and analyzed by researchers with these software tools, or with tools provided by the users and installed at the server. Alternatively, QIPCM provides a service for data analysis on the imaging data according developed SOP. An example of a clinical study in which patients with unresectable pancreatic adenocarcinoma were studied with dynamic PET-FAZA for hypoxia measurement will be discussed. We successfully quantified the degree of hypoxia as well as tumor perfusion in a group of 20 patients in terms of SUV and hypoxic fraction. It was found that there is no correlation between bulk tumor perfusion and hypoxia status in this cohort. QIPCM also provides end-to-end QA testing of scanners used in multi-center clinical trials. Based on quality assurance data from multiple CT-PET scanners, we concluded that quality control of imaging was vital in the success in multi-center trials as different imaging and reconstruction parameters in PET imaging could lead to very different results in hypoxia imaging. (author)

  15. Cancer patients’ use of pharmaceutical patient assistance programs in the outpatient pharmacy at a large tertiary cancer center

    Science.gov (United States)

    Felder, Tisha M.; Lal, Lincy S.; Bennett, Charles L.; Hung, Frank; Franzini, Luisa

    2011-01-01

    Purpose To report on the use of pharmaceutical patient assistance programs (PAPs) in the outpatient pharmacy at the largest tertiary cancer center in the United States. Methods We conducted a retrospective (July 1, 2006–Dec 31,2007) cross-sectional analysis of outpatient pharmacy, medical, and cancer registry records at the cancer center. The cancer center identified 104 medications available through PAPs. Study-eligible patients received at least one of these medications, either as a PAP case patient or as a PAP control non-user. Binary logit regression models predicted PAP use, and descriptive statistics compared PAP user and non-user medication fills. Results Of 25,552 cancer patients at who received an outpatient medication during the study period, 1,929 met study criteria (n=950 PAP users, 979 PAP non-users). In comparison to controls, PAP users were more likely to be uninsured (odds ratio (OR)=4.60, 95% confidence interval (CI): 2.118, 9.970), indigent (OR=16.95, 95% CI: 6.845, 41.960), and < 65 years old (OR=2.31, 95% CI: 1.517, 3.509). Of the most frequently dispensed medications to PAP users from PAPs (n=5,271), 88% (n=4,936) were for supportive care (e.g., nausea/vomiting). PAPs provided 35% (n=842) of the most common anticancer agents administered to PAP users (n=1,296), accounting for a monthly mean of $55,000 in pharmaceutical expenditures. Conclusions In the cancer center’s outpatient pharmacy, PAPs provided financial support for about a third of the most commonly used therapies, primarily for supportive care indications, for a small percentage of eligible cancer patients. PMID:22879815

  16. Nature and Status of Community College Leadership Development Programs

    Science.gov (United States)

    Hull, James R.; Keim, Marybelle C.

    2007-01-01

    This study was conducted because of the paucity of research on community college leadership development programs. A mailed survey was used to gather data from a national sample of incumbent community college presidents with 286 out of 389 responding for a return rate of 74%. Of national and regional programs, the Chair Academy, the Executive…

  17. Embracing Agile methodology during DevOps Developer Internship Program

    OpenAIRE

    Patwardhan, Amol; Kidd, Jon; Urena, Tiffany; Rajgopalan, Aishwarya

    2016-01-01

    The DevOps team adopted agile methodologies during the summer internship program as an initiative to move away from waterfall. The DevOps team implemented the Scrum software development strategy to create an internal data dictionary web application. This article reports on the transition process and lessons learned from the pilot program.

  18. The Benefits of Early Child Development Programs: An Economic Analysis.

    Science.gov (United States)

    van der Gaag, Jacques; Tan, Jee-Peng

    This paper provides a framework for estimating the economic benefits of early child development (ECD) programs and applies the framework to preliminary data from the Bolivian ECD program (known as the PIDI Project). The evaluation quantifies the benefits of increased lifetime productivity as a result of ECD enrollment. The evaluation also takes…

  19. Laboratory Directed Research and Development Program Assessment for FY 2014

    Energy Technology Data Exchange (ETDEWEB)

    Hatton, D. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2014-03-01

    Each year, Brookhaven National Laboratory (BNL) is required to provide a program description and overview of its Laboratory Directed Research and Development Program (LDRD) to the Department of Energy in accordance with DOE Order 413.2B dated April 19, 2006. This report fulfills that requirement.

  20. Geothermal energy, research, development and demonstration program. Third annual report

    Energy Technology Data Exchange (ETDEWEB)

    1979-03-01

    The following topics are covered: the geothermal resource potential in the U.S., national geothermal utilization estimates, the Federal geothermal development strategy and program, Federal progress and achievements FY 1978, regional progress FY 1978, and Federal program plans for FY 1979. (MHR)

  1. Talent Development Middle Grades Program. WWC Intervention Report

    Science.gov (United States)

    What Works Clearinghouse, 2009

    2009-01-01

    Talent Development Middle Grades Program (TDMG) is a whole school reform approach for large middle schools that face serious problems with student attendance, discipline, and academic achievement. The program includes both structural and curriculum reforms. The What Works Clearinghouse (WWC) identified 17 studies of TDMG that were published or…

  2. Effects of a Program for Developing Creative Thinking Skills

    Science.gov (United States)

    Rabanos, Natalia Larraz; Torres, Pedro Allueva

    2012-01-01

    Introduction: The aim of this study is to present an intervention program for creative skills development applied to a group of students of lower Secondary Education. Method: This program was applied in a school in Zaragoza (Spain) during the 2008-09 academic year. The study used a repeated-measures, quasi-experimental design with non-equivalent…

  3. A Critical Analysis of the Infant Health and Development Program.

    Science.gov (United States)

    Baumeister, Alfred A.; Bacharach, Verne R.

    1996-01-01

    An independent analysis of the database for the Infant Health and Development Program, an intervention of home visits, parent meetings, and preschool education designed to prevent mental retardation in children, suggests that the program has not, as supporters have claimed, had meaningful and lasting effects on children's IQs. (SLD)

  4. THE DEVELOPMENT OF A MENTOR PROGRAM TO FOSTER CAREER MANAGEMENT

    OpenAIRE

    Gregory A. Baker

    1998-01-01

    Because of dramatic changes in the employment environment and the increased frequency with which employees change jobs and careers, career management has become increasingly important. This article introduces and evaluates an academic Mentor Program that was developed in response to these changes. The Mentor Program provides students with many benefits including career counseling, practical work experience, employment opportunities, and networking.

  5. Health Occupations Education Program Development Guide No. 5: Dental Assisting.

    Science.gov (United States)

    New York State Education Dept., Albany. Div. of Occupational Education Instruction.

    The bulletin, which is part of the New York State "Health Occupations Education Program Development Guide Series," focuses on the dental assisting program. The curriculum is designed to provide training for dental assistants in their assistant role at chairside, in the dental operatory and laboratory, and in the dental office and reception area. A…

  6. Teacher Development Program for ATP 2000. Project Report.

    Science.gov (United States)

    Sutphin, Dean; And Others

    Agri Tech Prep 2000 (ATP 2000) is a 4-year tech prep program linking high school and postsecondary curricula designed to prepare New York students for careers in agriculture or acceptance into a college program in agriculture. Because teacher development was designated an integral project component for fiscal year 1991-1992, a weeklong teacher…

  7. A Professional Development Unit for Reflecting on Program Evaluator Competencies

    Science.gov (United States)

    Ghere, Gail; King, Jean A.; Stevahn, Laurie; Minnema, Jane

    2006-01-01

    This article describes an interactive professional development unit that engages both novice and experienced evaluators in (a) learning about the Essential Competencies for Program Evaluators (ECPE), (b) applying the competencies to program evaluation contexts, and (c) using the ECPE to reflect on their own professional practices. The article…

  8. Programming Embedded Systems With C and GNU Development Tools

    CERN Document Server

    Barr, Michael

    2009-01-01

    Whether you're writing your first embedded program, designing the latest generation of hand-held whatchamacalits, or managing the people who do, this book is for you. Programming Embedded Systems will help you develop the knowledge and skills you need to achieve proficiency with embedded software.

  9. Considering public confidence in developing regulatory programs

    International Nuclear Information System (INIS)

    In the area of public trust and in any investment, planning and strategy are important. While it is accepted in the United States that an essential part of our mission is to leverage our resources to improving Public Confidence this performance goal must be planned for, managed and measured. Similar to our premier performance goal of Maintaining Safety, a strategy must be developed and integrated with our external stake holders but with internal regulatory staff as well. In order to do that, business is to be conducted in an open environment, the basis for regulatory decisions has to be available through public documents and public meetings, communication must be done in clear and consistent terms. (N.C.)

  10. Australia's National Bowel Cancer Screening Program: does it work for Indigenous Australians?

    Directory of Open Access Journals (Sweden)

    Katzenellenbogen Judith M

    2010-06-01

    Full Text Available Abstract Background Despite a lower incidence of bowel cancer overall, Indigenous Australians are more likely to be diagnosed at an advanced stage when prognosis is poor. Bowel cancer screening is an effective means of reducing incidence and mortality from bowel cancer through early identification and prompt treatment. In 2006, Australia began rolling out a population-based National Bowel Cancer Screening Program (NBCSP using the Faecal Occult Blood Test. Initial evaluation of the program revealed substantial disparities in bowel cancer screening uptake with Indigenous Australians significantly less likely to participate in screening than the non-Indigenous population. This paper critically reviews characteristics of the program which may contribute to the discrepancy in screening uptake, and includes an analysis of organisational, structural, and socio-cultural barriers that play a part in the poorer participation of Indigenous and other disadvantaged and minority groups. Methods A search was undertaken of peer-reviewed journal articles, government reports, and other grey literature using electronic databases and citation snowballing. Articles were critically evaluated for relevance to themes that addressed the research questions. Results The NBCSP is not reaching many Indigenous Australians in the target group, with factors contributing to sub-optimal participation including how participants are selected, the way the screening kit is distributed, the nature of the test and comprehensiveness of its contents, cultural perceptions of cancer and prevailing low levels of knowledge and awareness of bowel cancer and the importance of screening. Conclusions Our findings suggest that the population-based approach to implementing bowel cancer screening to the Australian population unintentionally excludes vulnerable minorities, particularly Indigenous and other culturally and linguistically diverse groups. This potentially contributes to exacerbating

  11. Usability testing of an online self-management program for adolescents with cancer.

    Science.gov (United States)

    Stinson, Jennifer; Gupta, Abha; Dupuis, France; Dick, Bruce; Laverdière, Caroline; LeMay, Sylvie; Sung, Lillian; Dettmer, Elizabeth; Gomer, Stephanie; Lober, Janie; Chan, Carol Y

    2015-01-01

    The objective of this study was to explore the usability of a bilingual (English and French) Internet-based self-management program for adolescents with cancer and their parents and refine the Internet program. A qualitative study design with semistructured, audio-taped interviews and observation was undertaken with 4 iterative cycles. A purposive sample of English-speaking and French-speaking adolescents with cancer and one of their parents/caregivers was recruited. Adolescents and parents provided similar feedback on how to improve the usability of the Internet program. Most changes to the website were completed after the initial cycles of English and French testing. Both groups also found information presented on the website to be appropriate, credible, and relevant to their experiences of going through cancer. Participants reported the program would have been extremely helpful when they were first diagnosed with cancer. Usability testing uncovered some issues that affected the usability of the website that led to refinements in the online program. PMID:25037173

  12. Surgical leadership and standardization of multidisciplinary breast cancer care: the evolution of the National Accreditation Program for Breast Centers.

    Science.gov (United States)

    Bensenhaver, Jessica; Winchester, David P

    2014-07-01

    Evidence has shown that multidisciplinary specialist team evaluation and management for cancer results in better patient outcomes. For breast cancer, breast centers are where this evaluation and management occurs. The National Accreditation Program for Breast Centers has helped standardize multidisciplinary breast cancer care by defining services and standards required of accredited breast centers. PMID:24882354

  13. Advance crew procedures development techniques: Procedures generation program requirements document

    Science.gov (United States)

    Arbet, J. D.; Benbow, R. L.; Hawk, M. L.

    1974-01-01

    The Procedures Generation Program (PGP) is described as an automated crew procedures generation and performance monitoring system. Computer software requirements to be implemented in PGP for the Advanced Crew Procedures Development Techniques are outlined.

  14. Industrial development - consequences about the implantation of Brazilian Nuclear Program

    International Nuclear Information System (INIS)

    The strategy to promote the growing industry participation in the Brazilian Nuclear Program, the difficulties, the measurements adopted for overcoming and the results obtained in terms of industrial development, are presented. (M.C.K.)

  15. Development of a training program for nuclear policy makers

    International Nuclear Information System (INIS)

    This report is for studying on development of training program for nuclear policy makers. The objectives are as follows : 1. Establishing the efficient training system to acquire the necessary knowledge and the techniques for nuclear policy makers. 2. Developing the model training course and checking the efficiency of the training system through the model course. The scope and contents are as follows : 1. Collection and analysis of on-going training programs related to the issue of the project. 2. Establishment of an education and training system for nuclear policy makers. 3. Development of a training program for nuclear policy makers and carrying out a course as a test run. 4. Study on the feasibility of the developed training program through the evaluation of the test run

  16. Developing robotic behavior using a genetic programming model

    Energy Technology Data Exchange (ETDEWEB)

    Pryor, R.J. [Sandia National Labs., Albuquerque, NM (United States). Program Management Dept.

    1998-01-01

    This report describes the methodology for using a genetic programming model to develop tracking behaviors for autonomous, microscale robotic vehicles. The use of such vehicles for surveillance and detection operations has become increasingly important in defense and humanitarian applications. Through an evolutionary process similar to that found in nature, the genetic programming model generates a computer program that when downloaded onto a robotic vehicle`s on-board computer will guide the robot to successfully accomplish its task. Simulations of multiple robots engaged in problem-solving tasks have demonstrated cooperative behaviors. This report also discusses the behavior model produced by genetic programming and presents some results achieved during the study.

  17. Cross software for microprocessor program development at CERN

    International Nuclear Information System (INIS)

    Programs for a variety of microprocessors (including Intel 8080; Motorola 6800 and 6809 and 68000; and Texas Instruments 9900) can be prepared on different host computers (such as IBM 370, CDC 6000, and Nord 10) using portable programs developed at CERN. The range of cross software consists of: an assembler for each target microprocessor, a single linkage editor, a single object module librarian, and a variety of pre-loaders which convert object modules from CERN's format (CUFOM) into manufacturers' formats. The programs are written in BCPL and PASCAL, programming languages which are available on a wide range of computers. (orig.)

  18. Developing robotic behavior using a genetic programming model

    International Nuclear Information System (INIS)

    This report describes the methodology for using a genetic programming model to develop tracking behaviors for autonomous, microscale robotic vehicles. The use of such vehicles for surveillance and detection operations has become increasingly important in defense and humanitarian applications. Through an evolutionary process similar to that found in nature, the genetic programming model generates a computer program that when downloaded onto a robotic vehicle's on-board computer will guide the robot to successfully accomplish its task. Simulations of multiple robots engaged in problem-solving tasks have demonstrated cooperative behaviors. This report also discusses the behavior model produced by genetic programming and presents some results achieved during the study

  19. A Learning Tool and Program Development for Mechatronics Design Education

    Science.gov (United States)

    Iribe, Masatsugu; Shirahata, Akihiro; Kita, Hiromasa; Sasashige, Yousuke; Dasai, Ryoichi

    In this paper we propose a new type educational program for Mechatronics design which contributes to develop the physical sense and problem solving ability of the students who study Mechatronics design. For this program we provide a new handicraft kit of 4-wheeled car which is composed of inexpensive and commonplace parts, and the performance of the assembled 4-wheeled car is sensitive to its assembly arrangement. And then we implemented this program with the handicraft kit to the university freshmen, and verified its effectiveness, and report the results of the program.

  20. Development of an accident consequence analysis program based on the object oriented programming technique

    International Nuclear Information System (INIS)

    The KAERI accident consequence analysis program KAPAC is being developed on the basis of reusable objects in PPAM (platform for the development of plant analysis and management codes). Development of PPAM is being conducted at the Korea Atomic Energy Research Institute (KAERI) in order to be able to provide portability and reusability of computer codes, and consistent user interface in developing software with the use of object oriented programming (OOP) under a Microsoft Windows environment. By constructing the platform, software development can benefit from a shorter development cycle and an easier validation and verification process. 1 ref., 2 figs