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Sample records for cancer na populacao

  1. Mortality and cancer incident among residents in an area with a geological occurrence of uranium: the municipality of Monte Alegre, PA, Brazil; Avaliacao da incidencia e mortalidade por cancer na populacao residente em regiao com anomalia geologica na ocorrencia de uranio: estudo de caso: Monte Alegre, PA

    Energy Technology Data Exchange (ETDEWEB)

    Melo, Leticia Rodrigues

    2009-04-15

    The municipality of Monte Alegre, located in the Amazonian State of Para, Brazil, presents scattered areas with increased levels of natural radiation due to uranium rocks. The objectives of this dissertation were: to evaluate the mortality trend among Monte Alegre residents, and to compare it with that observed in neighbor municipalities (Alenquer and Prainha) without natural radiation sources; and to determine the impact of cancer distribution either in Monte Alegre or control counties population, taking into account their estimates of cancer incidence and mortality. The dissertation was organized in two papers. The first one aimed to evaluate the mortality trend for all causes of death, cancer, and unknown causes of death occurred between 1981-2005. Analyzed data was provided by the Brazilian National Mortality Information System (SIM), being the general population of the State of Para used as reference. In the second paper, cancer mortality risks at selected sites were ascertained using standardized mortality ratios (SMR) and mortality odds ratios (MOR). Additionally, cancer mortality risk ratios of Monte Alegre and control counties were obtained towards the ratio between SMRs of selected cancer sites in both areas. Three different sources of data were used to retrieve all cancer cases in the studied area, and therefore, to estimate cancer incidence in the studied populations: the diagnosed cancer cases at the regional reference centers for oncological care settled in Santarem, Belem and Manaus; the cancer-related hospitalization authorization records obtained at the Brazilian National Health System (SUS) registries; and primary data of cancer reported by local residents at a population-based health survey conducted by our research team in 2007-2008. A declining trend for all causes of death mortality in Monte Alegre general population, as well as for the unknown causes of death, was observed along the studied time series for both gender. Cancer mortality trend

  2. Influencia da organizacao da atencao basica e das caracteristicas sociodemograficas da populacao na demanda pelo pronto atendimento odontologico municipal

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    Dirce Aparecida Valerio da Fonseca

    2014-01-01

    Full Text Available O objetivo deste estudo foi avaliar a influência dos determinantes sociais e da oferta de serviços na atenção primária em relação à utilização de um serviço de pronto atendimento odontológico em município de médio porte. Foram utilizados para a análise dados de registros de 57.231 usuários do pronto atendimento, período de 2007 a 2009, segundo idade, sexo, data e período do atendimento, índice de exclusão social do bairro de residência e existência de equipe de saúde bucal de referência. Verificou-se que, em média/ano, 5,24% da população utilizou o serviço no período estudado, com maior procura na faixa etária de 20 a 49 anos (63,84% e equilíbrio entre os sexos. Os procedimentos mais executados foram os cirúrgicos (54,9% com tendência ao aumento dos procedimentos restauradores (62,8%. Os usuários residentes em áreas de maior exclusão social apresentaram 4,15 vezes mais chance de procurar pelo serviço (p < 0,05. Não foi observada associação estatisticamente significativa entre procura pelo pronto atendimento, sexo e a existência de equipe de saúde bucal na área de residência. Concluiu-se que houve uma maior utilização pelo serviço de urgência odontológico municipal por indivíduos provenientes de áreas mais vulneráveis, demonstrando a importância do mesmo na diminuição das iniquidades em saúde bucal.

  3. Bibliographic survey on methodologies for development of health database of the population in case of cancer occurrences; Levantamento bibliografico sobre metodologias para elaboracao de um banco de dados da saude da populacao em casos de ocorrencias de cancer

    Energy Technology Data Exchange (ETDEWEB)

    Cavinato, Christianne C.; Andrade, Delvonei A. de; Sabundjian, Gaiane, E-mail: christiannecobellocavinato@gmail.com, E-mail: delvonei@ipen.br, E-mail: gdjian@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Diz, Maria Del Pilar E., E-mail: maria.pilar@icesp.org.br [Instituto do Cancer do Estado de Sao Paulo (ICESP), Sao Paulo, SP (Brazil)

    2014-07-01

    The objective is to make a survey of existing methodologies and for the development of public health database, focusing on health (fatal and nonfatal cancer) of the population surrounding a nuclear facility, for purposes of calculating the environmental cost of the same. From methodologies found to develop this type of database, a methodology will be developed to be applied to the internal public of IPEN/CNEN-SP, Brazil, as a pre-test for the acquisition of health information desired.

  4. Delineamento e implementacao do biobanco do ELSA-Brasil: estudo prospectivo na populacao brasileira

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    Alexandre C Pereira

    2013-06-01

    Full Text Available O Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil é uma coorte prospectiva multicêntrica de funcionários públicos delineada para avaliar os determinantes das doenças crônicas, principalmente a doença cardiovascular e o diabetes tipo 2. Neste artigo são descritos os principais pontos do delineamento e implementação do projeto do biobanco do ELSA-Brasil. São detalhados aspectos econômicos, políticos, logísticos e tecnológicos do estudo. O artigo também discute o protocolo final de estocagem de material biológico e as instalações implementadas para atingir esse objetivo. O processo de delineamento e implementação do biobanco do ELSA-Brasil durou três anos. Tanto os biobancos centrais quanto os locais foram constituídos de acordo com as melhores práticas de estocagem de material biológico, usando soluções tecnológicas diferentes para as diferentes necessidades previstas no estudo.

  5. Estimativa de consumo de sodio pela populacao brasileira, 2008-2009

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    Flavio Sarno

    2013-06-01

    Full Text Available OBJETIVO: Atualizar estimativas sobre consumo de sódio no Brasil. MÉTODOS: Foram utilizados dados da Pesquisa de Orçamentos Familiares 2008-2009. Realizou-se a conversão em nutrientes dos registros de aquisição de alimentos dos domicílios brasileiros por meio de tabelas de composição de alimentos. Foram calculadas a disponibilidade média de sódio/pessoa/dia e a disponibilidade média ajustada para um consumo energético diário de 2.000 kcal. Calculou-se a contribuição de grupos de alimentos selecionados para o total de sódio disponível para consumo no domicílio e comparou-se com aqueles da Pesquisa de Orçamentos Familiares 2002-2003. RESULTADOS: A quantidade diária de sódio disponível para consumo nos domicílios brasileiros foi de 4,7 g para ingestão diária de 2.000 kcal, mantendo-se mais de duas vezes superior ao limite recomendado de ingestão desse nutriente. A maior parte do sódio disponível para consumo provém do sal de cozinha e de condimentos à base de sal (74,4%, mas a fração proveniente de alimentos processados com adição de sal aumentou linear e intensamente com o poder aquisitivo domiciliar (12,3% do total de sódio no quinto inferior da distribuição da renda por pessoa e 27,0% no quinto superior. Observou-se redução na contribuição de sal e condimentos à base de sal (76,2% para 74,4% e dos alimentos in natura ou processados sem adição de sal (6,6% para 4,8% e aumento dos alimentos processados com adição de sal (15,8% para 18,9% e dos pratos prontos (1,4% para 1,6% na comparação com a Pesquisa de Orçamentos Familiares 2002-2003. CONCLUSÕES: O consumo de sódio no Brasil mantém-se em níveis acima da recomendação máxima para esse nutriente em todas as macrorregiões e classes de renda brasileiras. Observou-se estabilidade na disponibilidade domiciliar total de sódio e aumento na fração proveniente dos alimentos processados com adição de sal e dos pratos prontos, na comparação de

  6. Programa Bolsa-Familia: qualidade da dieta de populacao adulta do municipio de Curitiba, PR

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    Flavia Emilia Leite de Lima

    2013-03-01

    Full Text Available Este estudo avaliou a qualidade da dieta da população beneficiária do Programa Bolsa-Família, em Curitiba, PR. Estudo transversal, de base populacional, realizado no período de julho de 2006 a julho de 2007. Foram entrevistados 747 beneficiários, a partir dos 19 anos de idade, de ambos os sexos. Para avaliação da qualidade da dieta foi aplicado recordatório de 24 horas, e o Índice de Qualidade da Dieta (IQD foi utilizado como parâmetro para classificação do grupo em níveis de consumo. Estatística descritiva foi utilizada para descrever a qualidade da dieta da população. Para a comparação de médias do índice segundo as variáveis socioeconômicas foram realizados o teste t de Wald e a análise de variância ANOVA, considerando-se um nível de significância de 5%. A amostra foi constituída por 91,4% de mulheres e 8,6 % de homens. A média de idade da população foi de 36,4 ± 13,3 anos, com cerca de 75 % possuindo o ensino fundamental incompleto. A média do IQD foi de 51 pontos, o que caracteriza uma dieta que precisa de ajustes. A população possui uma dieta monótona, com um consumo adequado de leguminosas, porém baixo para frutas, verduras e produtos lácteos. Na comparação entre as categorias de qualidade da dieta dos indivíduos, todos os componentes, com exceção do sódio, apresentaram medianas de pontuação estatisticamente diferentes (p < 0,01. Estudos que avaliem a qualidade da dieta são fundamentais para subsidiar a implantação de programas de educação alimentar direcionados para o cerne do problema nas populações estudadas.

  7. Instrumentos em Lingua Brasileira de Sinais para avaliacao da qualidade de vida da populacao surda

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    Neuma Chaveiro

    2013-06-01

    Full Text Available OBJETIVO: Construir a versão em Língua Brasileira de Sinais dos instrumentos WHOQOL-BREF e WHOQOL-DIS para avaliar a qualidade de vida da população surda brasileira. MÉTODOS: Utilizou-se metodologia proposta pela Organização Mundial da Saúde (WHOQOL-BREF e WHOQOL-DIS para a construção dos instrumentos adaptados para população surda em Língua Brasileira de Sinais (Libras. A pesquisa para execução do instrumento consistiu de 13 etapas: 1 criação do sinal qualidade de vida; 2 desenvolvimento das escalas de respostas em Libras; 3 tradução por um grupo bilíngue; 4 versão reconciliadora; 5 primeira retrotradução; 6 produção da versão em Libras a ser disponibilizada aos grupos focais; 7 realização dos grupos focais; 8 revisão por um grupo monolíngue; 9 revisão pelo grupo bilíngue; 10 análise sintática/semântica e segunda retrotradução; 11 reavaliação da retrotradução pelo grupo bilíngue; 12 filmagem da versão para o software; 13 desenvolvimento do software WHOQOL-BREF e WHOQOL-DIS em Libras. RESULTADOS: Características peculiares da cultura da população surda apontaram a necessidade de adaptações na metodologia de aplicação de grupos focais quando compostos por pessoas surdas. As convenções ortográficas da escrita das línguas sinalizadas não estão consolidadas, o que trouxe dificuldades em registrar graficamente as etapas de tradução. As estruturas linguísticas que causaram maiores problemas de tradução foram as que incluíram expressões idiomáticas do português, muitas sem conceitos equivalentes entre o português e a Libras. Foi possível construir um software do WHOQOL-BREF e WHOQOL-DIS em Libras. CONCLUSÕES: O WHOQOL-BREF e o WHOQOL-DIS em Libras possibilitarão que os surdos se expressem autonomamente quanto a sua qualidade de vida, o que permitirá investigar com maior precisão essas questões.

  8. Enzalutamide in Men with Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer

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    Beer, Tomasz M; Armstrong, Andrew J; Rathkopf, Dana;

    2017-01-01

    Enzalutamide significantly improved radiographic progression-free survival (rPFS) and overall survival (OS) among men with chemotherapy-naïve metastatic castration-resistant prostate cancer at the prespecified interim analysis of PREVAIL, a phase 3, double-blind, randomized study. We evaluated...

  9. SG2NA enhances cancer cell survival by stabilizing DJ-1 and thus activating Akt

    Energy Technology Data Exchange (ETDEWEB)

    Tanti, Goutam Kumar, E-mail: goutamjnu@hotmail.com; Pandey, Shweta; Goswami, Shyamal K.

    2015-08-07

    SG2NA in association with striatin and zinedin forms a striatin family of WD-40 repeat proteins. This family of proteins functions as scaffold in different signal transduction pathways. They also act as a regulatory subunit of protein phosphatase 2A. We have shown that SG2NA which evolved first in the metazoan evolution among the striatin family members expresses different isoforms generated out of alternative splicing. We have also shown that SG2NA protects cells from oxidative stress by recruiting DJ-1 and Akt to mitochondria and membrane in the post-mitotic neuronal cells. DJ-1 is both cancer and Parkinson's disease related protein. In the present study we have shown that SG2NA protects DJ-1 from proteasomal degradation in cancer cells. Hence, downregulation of SG2NA reduces DJ-1/Akt colocalization in cancer cells resulting in the reduction of anchorage dependent and independent growth. Thus SG2NA enhances cancer cell survival. Reactive oxygen species enhances SG2NA, DJ-1 and Akt trimerization. Removal of the reactive oxygen species by N-acetyl-cysteine thus reduces cancer cell growth. - Highlights: • Reactive oxygen species (ROS) play potential role in cancer cell proliferation. • It enhances the association between DJ-1 and Akt mediated by SG2NA. • In cancer cells SG2NA stabilizes DJ-1 by inhibiting it from proteosomal degradation. • DJ-1 then activates Akt and cancer cells get their property of enhanced proliferation by sustained activation of Akt. • Further study on this field could lead to new target for cancer therapy.

  10. 18F-NaF Positive Bone Metastases of Non 18F-FDG Avid Mucinous Gastric Cancer

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    Çiğdem Soydal

    2015-10-01

    Full Text Available Detection of gastric cancer bone metastasis is crucial since its presence is an independent prognostic factor. In this case report, we would like to present 18F-NaF positive bone metastases of non 18F-FDG avid gastric mucinous cancer

  11. Disrupting Na+,HCO3--cotransporter NBCn1 (Slc4a7) delays murine breast cancer development

    DEFF Research Database (Denmark)

    Lee, S.; Axelsen, T. V.; Andersen, Anne Poder

    2016-01-01

    Increased metabolism and insufficient blood supply cause acidic waste product accumulation in solid cancers. During carcinogenesis, cellular acid extrusion is upregulated but the underlying molecular mechanisms and their consequences for cancer growth and progression have not been established....... Genome-wide association studies have indicated a possible link between the Na(+),HCO3(-)-cotransporter NBCn1 (SLC4A7) and breast cancer. We tested the functional consequences of NBCn1 knockout (KO) for breast cancer development. NBCn1 protein expression increased 2.5-fold during breast carcinogenesis...... and was responsible for the increased net acid extrusion and alkaline intracellular pH of breast cancer compared with normal breast tissue. Genetic disruption of NBCn1 delayed breast cancer development: tumor latency was ~50% increased while tumor growth rate was ~65% reduced in NBCn1 KO compared with wild-type (WT...

  12. Contribution of Na+,HCOsub>3sub>--cotransport to cellular pH control in human breast cancer

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    Bødtkjer, Ebbe; Moreira, José; Mele, Marco;

    2013-01-01

    Genome-wide association studies recently linked the locus for Na(+) ,HCO(3) (-) -cotransporter NBCn1 (SLC4A7) to breast cancer susceptibility, yet functional insights have been lacking. To determine whether NBCn1, by transporting HCO(3) (-) into cells, may dispose of acid produced during high met...

  13. The Na+/H+ exchanger NHE1, but not the Na+, HCO3- cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2

    DEFF Research Database (Denmark)

    Lauritzen, Gitte; Stock, Christian-Martin; Lemaire, Justine;

    2012-01-01

    We and others have shown central roles of the Na(+)/H(+) exchanger NHE1 in cell motility. The aim of this study was to determine the roles of NHE1 and of the Na(+), HCO(3)(-) cotransporter NBCn1 in motility of serum-starved MCF-7 breast cancer cells expressing constitutively active ErbB2 (¿NErbB2...

  14. Silencing overexpression of FXYD3 protein in breast cancer cells amplifies effects of doxorubicin and γ-radiation on Na(+)/K(+)-ATPase and cell survival.

    Science.gov (United States)

    Liu, Chia-Chi; Teh, Rachel; Mozar, Christine A; Baxter, Robert C; Rasmussen, Helge H

    2016-01-01

    FXYD3, also known as mammary tumor protein 8, is overexpressed in several common cancers, including in many breast cancers. We examined if such overexpression might protect Na(+)/K(+)-ATPase and cancer cells against the high levels of oxidative stress characteristic of many tumors and often induced by cancer treatments. We measured FXYD3 expression, Na(+)/K(+)-ATPase activity and glutathionylation of the β1 subunit of Na(+)/K(+)-ATPase, a reversible oxidative modification that inhibits the ATPase, in MCF-7 and MDA-MB-468 cells. Expression of FXYD3 was suppressed by transfection with FXYD3 siRNA. A colorimetric end-point assay was used to estimate cell viability. Apoptosis was estimated by caspase 3/7 (DEVDase) activation using a Caspase fluorogenic substrate kit. Expression of FXYD3 in MCF-7 breast cancer cells was ~eightfold and ~twofold higher than in non-cancer MCF-10A cells and MDA-MB-468 cancer cells, respectively. A ~50 % reduction in FXYD3 expression increased glutathionylation of the β1 Na(+)/K(+)-ATPase subunit and reduced Na(+)/K(+)-ATPase activity by ~50 %, consistent with the role of FXYD3 to facilitate reversal of glutathionylation of the β1 subunit of Na(+)/K(+)-ATPase and glutathionylation-induced inhibition of Na(+)/K(+)-ATPase. Treatment of MCF-7 and MDA-MB- 468 cells with doxorubicin or γ-radiation decreased cell viability and induced apoptosis. The treatments upregulated FXYD3 expression in MCF-7 but not in MDA-MB-468 cells and suppression of FXYD3 in MCF-7 but not in MDA-MB-468 cells amplified effects of treatments on Na(+)/K(+)-ATPase activity and treatment-induced cell death and apoptosis. Overexpression of FXYD3 may be a marker of resistance to cancer treatments and a potentially important therapeutic target.

  15. Overexpression of NaV 1.6 channels is associated with the invasion capacity of human cervical cancer.

    Science.gov (United States)

    Hernandez-Plata, Everardo; Ortiz, Cindy S; Marquina-Castillo, Brenda; Medina-Martinez, Ingrid; Alfaro, Ana; Berumen, Jaime; Rivera, Manuel; Gomora, Juan C

    2012-05-01

    Functional activity of voltage-gated sodium channels (VGSC) has been associated to the invasion and metastasis behaviors of prostate, breast and some other types of cancer. We previously reported the functional expression of VGSC in primary cultures and biopsies derived from cervical cancer (CaC). Here, we investigate the relative expression levels of VGSC subunits and its possible role in CaC. Quantitative real-time PCR revealed that mRNA levels of Na(V) 1.6 α-subunit in CaC samples were ∼40-fold higher than in noncancerous cervical (NCC) biopsies. A Na(V) 1.7 α-subunit variant also showed increased mRNA levels in CaC (∼20-fold). All four Na(V) β subunits were also detected in CaC samples, being Na(V) β1 the most abundant. Proteins of Na(V) 1.6 and Na(V) 1.7 α-subunits were immunolocalized in both NCC and CaC biopsies and in CaC primary cultures as well; however, although in NCC sections proteins were mainly relegated to the plasma membrane, in CaC biopsies and primary cultures the respective signal was stronger and widely distributed in both cytoplasm and plasma membrane. Functional activity of Na(V) 1.6 channels in the plasma membrane of CaC cells was confirmed by whole-cell patch-clamp experiments using Cn2, a Na(V) 1.6-specific toxin, which blocked ∼30% of the total sodium current. Blocking of sodium channels VGSC with tetrodotoxin and Cn2 did not affect proliferation neither migration, but reduced by ∼20% the invasiveness of CaC primary culture cells in vitro assays. We conclude that Na(V) 1.6 is upregulated in CaC and could serve as a novel molecular marker for the metastatic behavior of this carcinoma.

  16. Cytostatic and pro-apoptotic effects of a novel phenylacetate-dextran derivative (NaPaC) on breast cancer cells in interactions with endothelial cells.

    Science.gov (United States)

    Malherbe, Séverine; Crépin, Michel; Legrand, Chantal; Wei, Ming Xing

    2004-11-01

    We have tested a novel hybrid molecule made of carboxymethylbenzylamide dextran (CMDB) and sodium phenylacetate (NaPa) groups, called the CMDB-NaPa ester (NaPaC), on the proliferation of breast cancer and endothelial cells as well as paracrine effects between these two cell types. Our results showed that NaPaC inhibited the proliferation of MDA-MB-231 cells and MCF-7 cells in a dose-dependent manner. NaPaC was 20-fold more active on highly invasive MDA-MB-231 cells than the NaPa parental molecule. On MCF-7 cells, which present a less aggressive phenotype, NaPaC was only 3-fold more active than the NaPa parental molecule. Furthermore, NaPaC had only a slight effect on the proliferation of primary cultured endothelial cells (HUVEC). A cytostatic effect of NaPaC on tumor cells was observed with cells accumulating in G0/G1 phase after 96 h of treatment. In addition, NaPaC induced a strong apoptotic effect on the two breast cancer cell lines. Conditioned media (CM) from tumor cells inhibited HUVEC proliferation, and this effect was enhanced in the presence of NaPaC (6 mM) and NaPa (10 mM). In addition to this cytostatic effect, CM from tumor cells induced a HUVEC early apoptosis which was increased, mainly, in the presence of NaPa (15 mM). Thus, this study shows that NaPaC is a more powerful anti-proliferative molecule than its parental NaPa molecule, with cytostatic and pro-apoptotic effects on MDA-MB-231 and MCF-7 tumor cells. Also, both molecules increased a pro-apoptotic effect of tumor cells on HUVEC.

  17. Cancer

    Science.gov (United States)

    ... cancer Non-Hodgkin lymphoma Ovarian cancer Pancreatic cancer Testicular cancer Thyroid cancer Uterine cancer Symptoms Symptoms of cancer ... tumor Obesity Pancreatic cancer Prostate cancer Stomach cancer Testicular cancer Throat or larynx cancer Thyroid cancer Patient Instructions ...

  18. Decrease of breast cancer cell invasiveness by sodium phenylacetate (NaPa) is associated with an increased expression of adhesive molecules

    OpenAIRE

    Vasse, M.; Thibout, D; Paysant, J; Legrand, E.; Soria, C.; Crépin, M

    2001-01-01

    Sodium phenylacetate (NaPa), a non-toxic phenylalanine metabolite, has been shown to induce in vivo and in vitro cytostatic and antiproliferative effects on various cell types. In this work, we analysed the effect of NaPa on the invasiveness of breast cancer cell (MDA-MB-231, MCF-7 and MCF-7 ras). Using the highly invasive breast cancer cell line MDA-MB-231, we demonstrated that an 18-hour incubation with NaPa strongly inhibits the cell invasiveness through Matrigel (86% inhibition at 20 mM o...

  19. Continuation maintenance therapy with S-1 in chemotherapy-naïve patients with advanced squamous cell lung cancer.

    Science.gov (United States)

    Suzuki, Seiichiro; Karayama, Masato; Inui, Naoki; Fujisawa, Tomoyuki; Enomoto, Noriyuki; Nakamura, Yutaro; Kuroishi, Shigeki; Matsuda, Hiroyuki; Yokomura, Koshi; Koshimizu, Naoki; Toyoshima, Mikio; Imokawa, Shiro; Asada, Kazuhiro; Masuda, Masafumi; Yamada, Takashi; Watanabe, Hiroshi; Suda, Takafumi

    2016-08-01

    Objectives Maintenance therapy is a standard therapeutic strategy in non-squamous non-small-cell lung cancer. However, there is no consensus regarding the benefit of maintenance therapy for patients with squamous cell lung cancer. We assessed maintenance therapy with S-1, an oral fluoropyrimidine agent, following induction therapy with carboplatin and S-1 in patients with squamous cell lung cancer. Methods In this phase II trial, chemotherapy-naïve patients with squamous cell lung cancer were enrolled to induction therapy with four cycles of carboplatin (at an area under the curve of 5 on day 1) and S-1 (80 mg/m(2)/day on days 1-14) in a 28-day cycle. Patients who achieved disease control after induction therapy received maintenance therapy with S-1 in a 21-day cycle until disease progression or unacceptable toxicity. The primary endpoint was progression-free survival after administration of maintenance therapy. Results Fifty-one patients were enrolled in the study. The median progression-free survival from the start of maintenance therapy was 3.0 months (95 % confidence interval, 2.5-3.5). The most common toxicities associated with maintenance therapy were anemia, thrombocytopenia, and fatigue, but they were not severe. Conclusion S-1 maintenance therapy might be a feasible treatment option in patients with squamous cell lung cancer.

  20. Dose-dependent changes in renal {sup 1}H-/{sup 23}Na MRI after adjuvant radiochemotherapy for gastric cancer

    Energy Technology Data Exchange (ETDEWEB)

    Haneder, Stefan [University Medical Centre Mannheim, University of Heidelberg, Institute of Clinical Radiology and Nuclear Medicine, Mannheim (Germany); University Hospital of Cologne, Department of Radiology, Cologne (Germany); Budjan, Johannes Michael; Schoenberg, Stefan Oswald [University Medical Centre Mannheim, University of Heidelberg, Institute of Clinical Radiology and Nuclear Medicine, Mannheim (Germany); Konstandin, Simon; Schad, Lothar Rudi [University Medical Centre Mannheim, University of Heidelberg, Computer Assisted Clinical Medicine, Mannheim (Germany); Hofheinz, Ralf Dieter [University Medical Centre Mannheim, University of Heidelberg, III. Department of Internal Medicine, Mannheim (Germany); Gramlich, Veronika; Wenz, Frederik; Lohr, Frank; Boda-Heggemann, Judit [University Medical Centre Mannheim, Medical Faculty Mannheim - University of Heidelberg, Department of Radiation Oncology, Mannheim (Germany)

    2015-04-01

    Combined radiochemotherapy (RCT) for gastric cancer with three-dimensional conformal radiotherapy (3D-CRT) results in ablative doses to the upper left kidney, while image-guided intensity-modulated radiotherapy (IG-IMRT) allows kidney sparing despite improved target coverage. Renal function in long-term gastric cancer survivors was evaluated with 3T functional magnetic resonance imaging (MRI) including diffusion-weighted imaging (DWI) and {sup 23}Na imaging. Five healthy volunteers and 13 patients after radiotherapy were included: 11 x IG-IMRT; 1 x 3D-CRT; 1 x ''positive control'' with stereotactic body radiotherapy (SBRT) of a metastasis between the spleen/left kidney. Radiation doses were documented for the upper/middle/lower kidney subvolumes. Late toxicity was evaluated based on CTC criteria, questionnaire, and creatinine values. Morphological sequences, DWI images, and {sup 23}Na images were acquired using a {sup 1}H/{sup 23}Na-tuned body-coil before/after intravenous water load (WL). Statistics for [{sup 23}Na] (concentration) and apparent diffusion coefficient (ADC) values were calculated for upper/middle/lower renal subvolumes. Corticomedullary [{sup 23}Na] gradients and [{sup 23}Na] differences after WL were determined. No major morphological alteration was detected in any patient. Minor scars were observed in the cranial subvolume of the left kidney of the 3D-CRT and the whole kidney of the control SBRT patient. All participants presented a corticomedullary [{sup 23}Na] gradient. After WL, a significant physiological [{sup 23}Na] gradient decrease (p < 0.001) was observed in all HV and IG-IMRT patients. In the cranial left kidney of the 3D-CRT patient and the positive control SBRT patient, the decrease was nonsignificant (p = 0.01, p = 0.02). ADC values were altered nonsignificantly in all renal subvolumes (all participants). Renal subvolumes with doses ≥ 35 Gy showed a reduced change of the [{sup 23}Na] gradient after WL (p = 0

  1. Magnetic resonance imaging in the evaluation of breast cancer; O uso da ressonancia magnetica na investigacao do cancer mamario

    Energy Technology Data Exchange (ETDEWEB)

    Alvares, Beatriz Regina [Universidade Estadual de Campinas, SP (Brazil). Faculdade de Ciencias Medicas. Dept. de Radiologia]. E-mail: alvaresb@terra.com.br; Michell, Michael [King' s College Hospital, London (United Kingdom). Dept. of Radiology and Nuclear Medicine

    2003-12-01

    Mammography, ultrasonography and scintimammography are essential examinations for the diagnosis and post-surgical follow-up of patients with breast cancer, although all these modalities may present specific limitations. In recent years magnetic resonance imaging has demonstrated good performance in detecting breast tumors in the mammary gland. In this study the authors describe the magnetic resonance imaging main indications and findings in patients with breast cancer, and compare the performance of mammography, ultrasonography and scintimammography, including the advantages and limitations of each modality. (author)

  2. Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling

    Science.gov (United States)

    House, Carrie D.; Wang, Bi-Dar; Ceniccola, Kristin; Williams, Russell; Simaan, May; Olender, Jacqueline; Patel, Vyomesh; Baptista-Hon, Daniel T.; Annunziata, Christina M.; Silvio Gutkind, J.; Hales, Tim G.; Lee, Norman H.

    2015-06-01

    Functional expression of voltage-gated Na+ channels (VGSCs) has been demonstrated in multiple cancer cell types where channel activity induces invasive activity. The signaling mechanisms by which VGSCs promote oncogenesis remain poorly understood. We explored the signal transduction process critical to VGSC-mediated invasion on the basis of reports linking channel activity to gene expression changes in excitable cells. Coincidentally, many genes transcriptionally regulated by the SCN5A isoform in colon cancer have an over-representation of cis-acting sites for transcription factors phosphorylated by ERK1/2 MAPK. We hypothesized that VGSC activity promotes MAPK activation to induce transcriptional changes in invasion-related genes. Using pharmacological inhibitors/activators and siRNA-mediated gene knockdowns, we correlated channel activity with Rap1-dependent persistent MAPK activation in the SW620 human colon cancer cell line. We further demonstrated that VGSC activity induces downstream changes in invasion-related gene expression via a PKA/ERK/c-JUN/ELK-1/ETS-1 transcriptional pathway. This is the first study illustrating a molecular mechanism linking functional activity of VGSCs to transcriptional activation of invasion-related genes.

  3. Further analysis of PREVAIL: Enzalutamide use in chemotherapy-naïve men with metastatic castration-resistant prostate cancer

    Directory of Open Access Journals (Sweden)

    Jeanny B Aragon-Ching

    2014-12-01

    Full Text Available PREVAIL was a phase III multinational, double-blind, placebo-controlled trial that enrolled chemotherapy-naïve men with metastatic castration-resistant prostate cancer (mCRPC, which showed remarkable improvement in co-primary endpoints with an overall 81% reduction in the risk of radiographic progression, as well as 29% reduction in the risk of death in favor of the enzalutamide arm over placebo. All secondary endpoints including time to subsequent chemotherapy initiation and prostate specific antigen (PSA progression were in favor of the enzalutamide arm. The results of PREVAIL shows the utility of enzalutamide that would likely soon expand the indication to asymptomatic or minimally symptomatic men with mCRPC not previously treated with chemotherapy.

  4. Collective dose estimation in Portuguese population due to medical exams of diagnostic radiology and nuclear medicine; Estimativa da dose coletiva na populacao portuguesa devido a exames medicos de radiologia de diagnostico e de medicina nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Teles, Pedro; Vaz, Pedro [Instituto Tecnologico e Nuclear, Sacavem (Portugal). Instituto Superior Tecnico; Sousa, M. Carmen de [Instituto Portugues de Oncologia de Coimbra (Portugal); Paulo, Graciano; Santos, Joana [Escola Superior de Tecnologia da Saude de Coimbra (Portugal); Pascoal, Ana [Kings College Hospital, London (United Kingdom). Kings Health Partners; Cardoso, Gabriela; Santos, Ana isabel [Hospital Garcia de Orta, Almada (Portugal); Lanca, Isabel [Administracao Regional de Saude, Coimbra (Portugal); Matela, Nuno [Universidade de Lisboa (Portugal). Fac. de Ciencias. Instituto de Biofisica e Engenharia Biomedica; Janeiro, Luis [Escola superior de Saude da Cruz Vermelha Portuguesa, Lisboa (Portugal); Sousa, Patrick [Laboratorio de Instrumentacao e Fisica Experimental de Particulas, Lisboa (Portugal); Carvoeiras, Pedro; Parafita, Rui [Medical Consult, SA, Lisboa (Portugal); Simaozinho, Paula [Administracao Regional de Saude, Faro (Portugal)

    2013-11-01

    In order to assess the exposure of the Portuguese population to ionizing radiation due to medical examinations of diagnostic radiology and nuclear medicine, a working group, consisting of 40 institutions, public and private, was created to evaluation the coletive dose in the Portuguese population in 2010. This work was conducted in collaboration with the Dose Datamed European consortium, which aims to assess the exposure of the European population to ionizing radiation due to 20 diagnostic radiology examinations most frequent in Europe (the 'TOP 20') and nuclear medicine examinations. We obtained an average value of collective dose of Almost-Equal-To 1 mSv/caput, which puts Portugal in the category of countries medium to high exposure to Europe. We hope that this work can be a starting point to bridge the persistent lack of studies in the areas referred to in Portugal, and to enable the characterization periodic exposure of the Portuguese population to ionizing radiation in the context of medical applications.

  5. Câncer na população feminina brasileira Cancer among women in Brazil

    Directory of Open Access Journals (Sweden)

    Guinar Azevedo e Silva Mendonça

    1993-02-01

    Full Text Available Objetivou-se mostrar a importância do câncer enquanto causa de morte e morbidade para a população feminina brasileira. Foram analisados os dados das estatísticas de mortalidade do Ministério da Saúde e os disponíveis nos registros de câncer de base populacional existentes nos municípios em Belém, Fortaleza, Recife, Goiânia, São Paulo e Porto Alegre (Brasil. Em 1986 o câncer foi responsável por 15,5% dos óbitos em mulheres acima de quinze anos no Brasil. Os cânceres de mama e útero representaram quase um terço desses óbitos. A comparação internacional mostrou que os coeficientes de incidência de câncer de colo de útero em Recife e Belém foram os mais altos do mundo e os de mama em Fortaleza e São Paulo são próximos dos encontrados nas regiões de mais altas cifras como nos Estados Unidos e alguns países da Europa. São discutidos os principais fatores de risco para os cânceres mais prevalentes entre as mulheres brasileiras, guardando as diferenças culturais, sociais e geográficas, bem como os programas de controle existentes. Conclui-se que os programas, de "screening" e de diagnóstico precoce para o câncer de colo uterino tiveram coberturas muito baixas. Considerou-se que o estabelecimento de uma política assistêncial e de controle que inclua a prevenção e o diagnóstico precoce para os cânceres de colo uterino e de mama nos programas de assistência à mulher deveria ser uma das prioridades de saúde pública, no Brasil.This study seeks to show the importance of cancer as a cause of morbidity and mortality among Brazilian women. Mortality data from the Health Ministry and incidence data from the six Brazilian Population Based Cancer Registries (Belém, Fortaleza, Recife, S. Paulo, Porto Alegre e Goiânia were used. Cancer accounted for 15.5% of all deaths in women above fifteen years of age, in 1986. Breast and uterine cancer were responsible for some 30% of these deaths. International comparisons show

  6. Adesao ao guia alimentar para populacao brasileira

    Directory of Open Access Journals (Sweden)

    Eliseu Verly Junior

    2013-12-01

    Full Text Available OBJETIVO : Analisar a adesão ao Guia Alimentar para População Brasileira. MÉTODOS : Amostra composta por participantes do Inquérito de Saúde de São Paulo (n = 1.661 que preencheram dois recordatórios de 24 horas. Foi utilizado modelo bivariado de efeito misto para a razão entre o consumo de energia do grupo de alimentos e o consumo calórico total. A razão estimada foi utilizada para calcular o percentual de indivíduos com consumo abaixo ou acima da recomendação. RESULTADOS : Pelo menos 80,0% da população consome abaixo do recomendado para: leite e derivados; frutas e sucos de frutas; e cereais, tubérculos e raízes; aproximadamente 60,0% para legumes e verduras; 30,0% para feijões; e 8,0% para carnes e ovos. Adolescentes apresentaram a maior inadequação para legumes e verduras (90,0%, e o estrato de maior renda foi associado à menor inadequação para óleos, gorduras e sementes oleaginosas (57,0%. CONCLUSÕES : Foi observado consumo inadequado dos grupos de alimentos relacionados com aumento do risco de doenças crônicas.

  7. Decrease of breast cancer cell invasiveness by sodium phenylacetate (NaPa) is associated with an increased expression of adhesive molecules.

    Science.gov (United States)

    Vasse, M; Thibout, D; Paysant, J; Legrand, E; Soria, C; Crépin, M

    2001-03-23

    Sodium phenylacetate (NaPa), a non-toxic phenylalanine metabolite, has been shown to induce in vivo and in vitro cytostatic and antiproliferative effects on various cell types. In this work, we analysed the effect of NaPa on the invasiveness of breast cancer cell (MDA-MB-231, MCF-7 and MCF-7 ras). Using the highly invasive breast cancer cell line MDA-MB-231, we demonstrated that an 18-hour incubation with NaPa strongly inhibits the cell invasiveness through Matrigel (86% inhibition at 20 mM of NaPa). As cell invasiveness is greatly influenced by the expression of urokinase (u-PA) and its cell surface receptor (u-PAR) as well as the secretion of matrix metalloproteinases (MMP), we tested the effect of NaPa on these parameters. An 18-hour incubation with NaPa did not modify u-PA expression, either on MDA-MB-231 or on MCF-7 and MCF-7 ras cell lines, and induced a small u-PA decrease after 3 days of treatment of MDA-MB-321 with NaPa. In contrast, an 18 h incubation of MDA-MB-231 increased the expression of u-PAR and the secretion of MMP-9. As u-PAR is a ligand for vitronectin, a composant of the extracellular matrix, these data could explain the increased adhesion of MDA-MB-231 to vitronectin, while cell adhesivity of MCF-7 and MCF-7 ras was unmodified by NaPa treatment. NaPa induced also an increased expression of both Lymphocyte Function-Associated-1 (LFA-1) and Intercellular Adhesion Molecule-1 (ICAM-1), which was obvious from 18 hour incubation with NaPa for the MDA-MB-231 cells, but was delayed (3 days) for MCF-7 and MCF-7 ras. Only neutralizing antibodies against LFA-1 reversed the decreased invasiveness of NaPa-treated cells. Therefore we can conclude that the strong inhibition of MDA-MB-231 invasiveness is not due to a decrease in proteases involved in cell migration (u-PA and MMP) but could be related both to the modification of cell structure and an increased expression of adhesion molecules such as u-PAR and LFA-1.

  8. NaYF4:Yb/Er@PPy core-shell nanoplates: an imaging-guided multimodal platform for photothermal therapy of cancers

    Science.gov (United States)

    Huang, Xiaojuan; Li, Bo; Peng, Chen; Song, Guosheng; Peng, Yuxuan; Xiao, Zhiyin; Liu, Xijian; Yang, Jianmao; Yu, Li; Hu, Junqing

    2015-12-01

    Imaging guided photothermal agents have attracted great attention for accurate diagnosis and treatment of tumors. Herein, multifunctional NaYF4:Yb/Er@polypyrrole (PPy) core-shell nanoplates are developed by combining a thermal decomposition reaction and a chemical oxidative polymerization reaction. Within such a composite nanomaterial, the core of the NaYF4:Yb/Er nanoplate can serve as an efficient nanoprobe for upconversion luminescence (UCL)/X-ray computed tomography (CT) dual-modal imaging, the shell of the PPy shows strong near infrared (NIR) region absorption and makes it effective in photothermal ablation of cancer cells and infrared thermal imaging in vivo. Thus, this platform can be simultaneously used for cancer diagnosis and photothermal therapy, and compensates for the deficiencies of individual imaging modalities and satisfies the higher requirements on the efficiency and accuracy for diagnosis and therapy of cancer. The results further provide some insight into the exploration of multifunctional nanocomposites in the photothermal theragnosis therapy of cancers.Imaging guided photothermal agents have attracted great attention for accurate diagnosis and treatment of tumors. Herein, multifunctional NaYF4:Yb/Er@polypyrrole (PPy) core-shell nanoplates are developed by combining a thermal decomposition reaction and a chemical oxidative polymerization reaction. Within such a composite nanomaterial, the core of the NaYF4:Yb/Er nanoplate can serve as an efficient nanoprobe for upconversion luminescence (UCL)/X-ray computed tomography (CT) dual-modal imaging, the shell of the PPy shows strong near infrared (NIR) region absorption and makes it effective in photothermal ablation of cancer cells and infrared thermal imaging in vivo. Thus, this platform can be simultaneously used for cancer diagnosis and photothermal therapy, and compensates for the deficiencies of individual imaging modalities and satisfies the higher requirements on the efficiency and accuracy for

  9. Carcinoma de mama: novos conceitos na classificação Breast cancer: new concepts in classification

    Directory of Open Access Journals (Sweden)

    Daniella Serafin Couto Vieira

    2008-01-01

    Full Text Available O carcinoma de mama é a neoplasia maligna mais comum em mulheres. Estudos moleculares do carcinoma de mama, baseados na identificação do perfil de expressão gênica por meio do cDNA microarray, permitiram definir pelo menos cinco sub-grupos distintos: luminal A, luminal B, superexpressão do HER2, basal e normal breast-like. A técnica de tissue microarray (TMA, descrita pela primeira vez em 1998, permitiu estudar, em várias amostras de carcinoma, os perfis de expressão protéica de diferentes neoplasias. No carcinoma de mama, os TMAs têm sido utilizados para validar os achados dos estudos preliminares, identificando, desta forma, os novos subtipos fenotípicos do carcinoma de mama. Dentre os subtipos classicamente descritos, o grupo basal constitui um dos mais intrigantes subtipos tumorais e é freqüentemente associado com pior prognóstico e ausência de alvos terapêuticos definidos. A classificação histopatológica do carcinoma de mama tem pobre valor preditivo. Portanto, a associação entre o diagnóstico histológico com técnicas moleculares nos laboratórios de anatomia patológica, por meio do estudo imunoistoquímico, pode determinar o perfil molecular do carcinoma de mama, buscando melhorar a resposta terapêutica. Este estudo visou resumir os mais recentes conhecimentos em que se baseiam os novos conceitos da classificação do carcinoma de mama.Breast cancer is the principal cause of death from cancer in women. Molecular studies of breast cancer, based in the identification of the molecular profiling techniques through cDNA microarray, had allowed defining at least five distinct sub-group: luminal A, luminal B, HER-2-overexpression, basal and " normal" type breast-like. The technique of tissue microarrays (TMA, described for the first time in 1998, allows to study, in some samples of breast cancer, distinguished by differences in their gene expression patterns, which provide a distinctive molecular portrait for each tumor

  10. 21-Benzylidene Digoxin: A Proapoptotic Cardenolide of Cancer Cells That Up-Regulates Na,K-ATPase and Epithelial Tight Junctions

    Science.gov (United States)

    Rocha, Sayonarah C.; Pessoa, Marco T. C.; Neves, Luiza D. R.; Alves, Silmara L. G.; Silva, Luciana M.; Santos, Herica L.; Oliveira, Soraya M. F.; Taranto, Alex G.; Comar, Moacyr; Gomes, Isabella V.; Santos, Fabio V.; Paixão, Natasha; Quintas, Luis E. M.; Noël, François; Pereira, Antonio F.; Tessis, Ana C. S. C.; Gomes, Natalia L. S.; Moreira, Otacilio C.; Rincon-Heredia, Ruth; Varotti, Fernando P.; Blanco, Gustavo; Villar, Jose A. F. P.; Contreras, Rubén G.; Barbosa, Leandro A.

    2014-01-01

    Cardiotonic steroids are used to treat heart failure and arrhythmia and have promising anticancer effects. The prototypic cardiotonic steroid ouabain may also be a hormone that modulates epithelial cell adhesion. Cardiotonic steroids consist of a steroid nucleus and a lactone ring, and their biological effects depend on the binding to their receptor, Na,K-ATPase, through which, they inhibit Na+ and K+ ion transport and activate of several intracellular signaling pathways. In this study, we added a styrene group to the lactone ring of the cardiotonic steroid digoxin, to obtain 21-benzylidene digoxin (21-BD), and investigated the effects of this synthetic cardiotonic steroid in different cell models. Molecular modeling indicates that 21-BD binds to its target Na,K-ATPase with low affinity, adopting a different pharmacophoric conformation when bound to its receptor than digoxin. Accordingly, 21-DB, at relatively high µM amounts inhibits the activity of Na,K-ATPase α1, but not α2 and α3 isoforms. In addition, 21-BD targets other proteins outside the Na,K-ATPase, inhibiting the multidrug exporter Pdr5p. When used on whole cells at low µM concentrations, 21-BD produces several effects, including: 1) up-regulation of Na,K-ATPase expression and activity in HeLa and RKO cancer cells, which is not found for digoxin, 2) cell specific changes in cell viability, reducing it in HeLa and RKO cancer cells, but increasing it in normal epithelial MDCK cells, which is different from the response to digoxin, and 3) changes in cell-cell interaction, altering the molecular composition of tight junctions and elevating transepithelial electrical resistance of MDCK monolayers, an effect previously found for ouabain. These results indicate that modification of the lactone ring of digoxin provides new properties to the compound, and shows that the structural change introduced could be used for the design of cardiotonic steroid with novel functions. PMID:25290152

  11. 21-Benzylidene digoxin: a proapoptotic cardenolide of cancer cells that up-regulates Na,K-ATPase and epithelial tight junctions.

    Directory of Open Access Journals (Sweden)

    Sayonarah C Rocha

    Full Text Available Cardiotonic steroids are used to treat heart failure and arrhythmia and have promising anticancer effects. The prototypic cardiotonic steroid ouabain may also be a hormone that modulates epithelial cell adhesion. Cardiotonic steroids consist of a steroid nucleus and a lactone ring, and their biological effects depend on the binding to their receptor, Na,K-ATPase, through which, they inhibit Na+ and K+ ion transport and activate of several intracellular signaling pathways. In this study, we added a styrene group to the lactone ring of the cardiotonic steroid digoxin, to obtain 21-benzylidene digoxin (21-BD, and investigated the effects of this synthetic cardiotonic steroid in different cell models. Molecular modeling indicates that 21-BD binds to its target Na,K-ATPase with low affinity, adopting a different pharmacophoric conformation when bound to its receptor than digoxin. Accordingly, 21-DB, at relatively high µM amounts inhibits the activity of Na,K-ATPase α1, but not α2 and α3 isoforms. In addition, 21-BD targets other proteins outside the Na,K-ATPase, inhibiting the multidrug exporter Pdr5p. When used on whole cells at low µM concentrations, 21-BD produces several effects, including: 1 up-regulation of Na,K-ATPase expression and activity in HeLa and RKO cancer cells, which is not found for digoxin, 2 cell specific changes in cell viability, reducing it in HeLa and RKO cancer cells, but increasing it in normal epithelial MDCK cells, which is different from the response to digoxin, and 3 changes in cell-cell interaction, altering the molecular composition of tight junctions and elevating transepithelial electrical resistance of MDCK monolayers, an effect previously found for ouabain. These results indicate that modification of the lactone ring of digoxin provides new properties to the compound, and shows that the structural change introduced could be used for the design of cardiotonic steroid with novel functions.

  12. Imaging patients with breast and prostate cancers using combined 18F NaF/18F FDG and TOF simultaneous PET/ MRI

    Energy Technology Data Exchange (ETDEWEB)

    Iagaru, Andrei; Minamimoto, Ryogo; Jamali, Mehran; Barkodhodari, Amir; Gambhir, Sanjiv Sam; Vasanawala, Shreyas [Stanford University, Department of Radiology, Division of Nuclear Medicine and Molecular Imaging (United States)

    2015-05-18

    Here we prospectively compared the combined 18F NaF/18F FDG PET/ MRI against 99mTc-MDP in patients with breast and prostate cancers. Twelve patients referred for 99mTc-MDP bone scans were prospectively enrolled from Oct 14 - Jan 15. The cohort included 6 men with prostate cancer and 6 women with breast cancer, 41 – 85 year-old (average 63 ± 15). 18F NaF (0.7-2.2 mCi, mean: 1.33 mCi) and 18F FDG (3.9-5.2 mCi, mean: 4.6 mCi) were subsequently injected from separate syringes. The PET/MRI was done 6-12 days (average 9.3 ± 3.2) after bone scan. The whole body MRI protocol consisted of T2-weighted, DWI, and contrast-enhanced T1-weighted imaging. Lesions detected with each test were tabulated and the results were compared. All patients tolerated the PET/MRI exam, and PET image quality was diagnostic despite the marked reduction in the administered dosage of radiopharmaceuticals (80% less for 18F NaF and 67% less for 18F FDG). Five patients had no bone metastases identified on either scans. Bone scintigraphy and PET/MRI showed osseous metastases in 7 patients, but more numerous bone findings were noted on PET/MRI than on bone scintigraphy in 3 patients. Lesions outside the skeleton were identified by PET/MRI in 2 patients. The combined 18F NaF/18F FDG PET/MRI is superior to 99mTc-MDP scintigraphy for evaluation of skeletal disease extent. Further, it detected extra- skeletal disease that may change the management of these patients, while allowing a significant reduction in radiation exposure from lower dosages of PET radiopharmaceuticals administered. A combination of 18F NaF/18F FDG PET/MRI may provide the most accurate staging of patients with breast and prostate cancers prior to the start of treatment.

  13. Early apoptosis and cell death induced by ATX-S10Na ( Ⅱ)-mediated photodynamic therapy are Bax- and p53-dependent in human colon cancer cells

    Institute of Scientific and Technical Information of China (English)

    Makoto Mitsunaga; Akihito Tsubota; Kohichi Nariai; Yoshihisa Namiki; Makoto Sumi; Tetsuya Yoshikawa; Kiyotaka Fujise

    2007-01-01

    AIM: To investigate the roles of Bax and p53 proteins in photosensitivity of human colon cancer cells by using lysosome-localizing photosensitizer, ATX-S10Na (Ⅱ).METHODS: HCT116 human colon cancer cells and Bax-null or p53-null isogenic derivatives were irradiated with a diode laser. Early apoptosis and cell death in response to photodynamic therapy were determined by MTT assays, annexin V assays, transmission electron microscopy assays, caspase assays and western blotting.RESULTS: Induction of early apoptosis and cell death was Bax- and p53-dependent. Bax and p53 were required for caspase-dependent apoptosis. The levels of anti-apoptotic Bcl-2 family proteins, Bcl-2 and Bcl-XL,were decreased in Bax- and p53-independent manner.CONCLUSION: Our results indicate that early apoptosis and cell death of human colon cancer cells induced by photodynamic therapy with lysosome-localizingphotosensitizer ATX-S10Na (Ⅱ) are mediated by p53-Bax network and Iow levels of Bcl-2 and Bcl-XL proteins.Our results might help in formulating new therapeutic approaches in photedynamic therapy.

  14. The cellular distribution of Na+/H+ exchanger regulatory factor 1 is determined by the PDZ-I domain and regulates the malignant progression of breast cancer

    Science.gov (United States)

    Du, Guifang; Gu, Yanan; Hao, Chengcheng; Yuan, Zhu; He, Junqi; Jiang, Wen G.; Cheng, Shan

    2016-01-01

    The oncogenic role of ectopic expression of Na+/H+ exchanger regulatory factor 1 (NHERF1) was recently suggested. Here, we show that NHERF1 was upregulated in high grades compared with low grades. Increased NHERF1 expression was correlated with poor prognosis and poor survival. NHERF1 expression was higher in the nucleus of cancer cells than in contiguous non- mammary epithelial cells. A novel mutation, namely NHERF1 Y24S, was identified in human breast cancer tissues and shown to correspond to a conserved residue in the PDZ-I domain of NHERF1. Truncation and mutation of the PDZ-I domain of NHERF1 increased the nuclear distribution of the NHERF1 protein, and this redistribution was associated with the malignant phenotype of breast cancer cells, including growth, migration, and adhesion. The present results suggest a role for NHERF1 in the progression of breast cancer mediated by the nuclear distribution of the NHERF1 protein, as determined by the truncation or key site mutation of the PDZ-I domain. PMID:27097111

  15. Naïve Bayes QSDR classification based on spiral-graph Shannon entropies for protein biomarkers in human colon cancer.

    Science.gov (United States)

    Aguiar-Pulido, Vanessa; Munteanu, Cristian R; Seoane, José A; Fernández-Blanco, Enrique; Pérez-Montoto, Lázaro G; González-Díaz, Humberto; Dorado, Julián

    2012-06-01

    Fast cancer diagnosis represents a real necessity in applied medicine due to the importance of this disease. Thus, theoretical models can help as prediction tools. Graph theory representation is one option because it permits us to numerically describe any real system such as the protein macromolecules by transforming real properties into molecular graph topological indices. This study proposes a new classification model for proteins linked with human colon cancer by using spiral graph topological indices of protein amino acid sequences. The best quantitative structure-disease relationship model is based on eleven Shannon entropy indices. It was obtained with the Naïve Bayes method and shows excellent predictive ability (90.92%) for new proteins linked with this type of cancer. The statistical analysis confirms that this model allows diagnosing the absence of human colon cancer obtaining an area under receiver operating characteristic of 0.91. The methodology presented can be used for any type of sequential information such as any protein and nucleic acid sequence.

  16. Functional characterization and anti-cancer action of the clinical phase II cardiac Na+/K+ ATPase inhibitor istaroxime: in vitro and in vivo properties and cross talk with the membrane androgen receptor

    Science.gov (United States)

    Alevizopoulos, Konstantinos; Dimas, Konstantinos; Papadopoulou, Natalia; Schmidt, Eva-Maria; Tsapara, Anna; Alkahtani, Saad; Honisch, Sabina; Prousis, Kyriakos C.; Alarifi, Saud; Calogeropoulou, Theodora

    2016-01-01

    Sodium potassium pump (Na+/K+ ATPase) is a validated pharmacological target for the treatment of various cardiac conditions. Recent published data with Na+/K+ ATPase inhibitors suggest a potent anti-cancer action of these agents in multiple indications. In the present study, we focus on istaroxime, a Na+/K+ ATPase inhibitor that has shown favorable safety and efficacy properties in cardiac phase II clinical trials. Our experiments in 22 cancer cell lines and in prostate tumors in vivo proved the strong anti-cancer action of this compound. Istaroxime induced apoptosis, affected the key proliferative and apoptotic mediators c-Myc and caspase-3 and modified actin cystoskeleton dynamics and RhoA activity in prostate cancer cells. Interestingly, istaroxime was capable of binding to mAR, a membrane receptor mediating rapid, non-genomic actions of steroids in prostate and other cells. These results support a multi-level action of Na+/K+ ATPase inhibitors in cancer cells and collectively validate istaroxime as a strong re-purposing candidate for further cancer drug development. PMID:27027435

  17. Can we improve the definition of high-risk, hormone naïve, non-metastatic prostate cancer?

    Science.gov (United States)

    Tombal, Bertrand; Alcaraz, Antonio; James, Nicholas; Valdagni, Riccardo; Irani, Jacques

    2014-02-01

    To identify criteria beyond Tumour-Node-Metastasis (TMN)-, prostate-specific antigen (PSA)- and Gleason score-based standard classifications to enhance the stratification of non-metastatic high-risk prostate cancer. A detailed search of the literature was performed using PubMed. The authors reviewed the literature and used a modified Delphi approach to identify relevant approaches to enhance standard classifications. Specific criteria for high-risk prostate cancer vary across guidelines and clinical trials, reflecting the differing perspectives concerning the definition of 'risk' between different specialities within the urology/radiation oncology community. In addition to the present classifications, evidence exists that the measure of cancer volume can provide additional prognostic value. More accurate imaging, especially multiparametric magnetic resonance imaging can also provide information concerning staging and cancer volume, and thus may assist in the identification of patients with high-risk prostate cancer. A refined definition of non-metastatic high-risk prostate cancer is proposed. Within this high-risk cohort, patients with multiple high-risk criteria are especially at risk of prostate cancer-specific mortality.

  18. SU-C-BRA-01: 18F-NaF PET/CT-Directed Dose Escalation in Stereotactic Body Radiotherapy for Spine Oligometastases From Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Wu, L [Cancer Hospital of Shantou University Medical College, Shantou, Guangdong (China); University of Nevada, Las Vegas, Las Vegas, NV (United States); Zhang, W; Li, M; Peng, X; Xie, L; Lin, Z [Cancer Hospital of Shantou University Medical College, Shantou, Guangdong (China); Kwee, S [The Queen’s Medical Center, Honolulu, HI (United States); Wang, H; Kuang, Y [University of Nevada, Las Vegas, Las Vegas, NV (United States)

    2015-06-15

    Purpose: To investigate the technical feasibility of SBRT dose painting using {sup 18}F-NaF positron emission tomography (PET) scans guidance in patients with spine oligometastases from prostate cancer. Methods: As a proof of concept, six patients with 14 spine oligometastatic lesions from prostate cancer who had {sup 18}F-NaF PET/CT scan prior to treatment were retrospectively included. GTV{sub reg} was delineated according to the regular tumor boundary shown on PET and/or CT images; and GTV{sub MATV} was contoured based on a net metabolically active tumor volume (MATV) defined by 60% of the SUV{sub max} values on {sup 18}F-NaF PET images. The PTVs (PTV{sub reg} and PTV{sub MATV}) were defined as respective GTVs (plus involved entire vertebral body for PTV{sub reg}) with a 3-mm isotropic expansion margin. Three 1-fraction SBRT plans using VMAT technique along with 10 MV FFF beams (Plan{sub 24Gy}, Plan{sub 24–27Gy}, and Plan{sub 24–30Gy}) were generated for each patient. All plans included a dose of 24 Gy prescribed to PTV{sub reg}. The Plan{sub 24–27Gy} and Plan{sub 24–30Gy} also included a simultaneous boost dose of 27 Gy or 30 Gy prescribed to the PTV{sub MATV}, respectively. The feasibility of 18F-NaF PET-guided SBRT dose escalation was evaluated by its ability to achieve the prescription dose objectives while adhering to organ-at-risk (OAR) dose constraints. The normal tissue complication probabilities (NTCP) calculated by radiological models were also compared between the plans. Results: In all 33 SBRT plans generated, the planning objectives and dose constraints were met without exception. Plan{sub 24–27Gy} and Plan{sub 24–30Gy} had a significantly higher dose in PTV{sub MATV} than Plan{sub 24Gy} (p < 0.05), respectively, while maintaining a similar OAR sparing profile and NTCP values. Conclusion: Using VMAT with FFF beams to incorporate a simultaneous {sup 18}F-NaF PET-guided radiation boost dose up to 30 Gy into a SBRT plan is technically

  19. Rationale for stereotactic body radiation therapy in treating patients with oligometastatic hormone-naïve prostate cancer

    Directory of Open Access Journals (Sweden)

    Onita eBhattasali

    2013-12-01

    Full Text Available Despite advances in treatment for metastatic prostate cancer, patients eventually progress to castrate-resistant disease and ultimately succumb to their cancer. Androgen deprivation therapy (ADT is the standard treatment for metastatic prostate cancer and has been shown to improve median time to progression and median survival time. Research suggests that castrate-resistant clones may be present early in the disease process prior to the initiation of ADT. These clones are not susceptible to ADT and may even flourish when androgen-responsive clones are depleted. Stereotactic body radiation therapy (SBRT is a safe and efficacious method of treating clinically localized prostate cancer and metastases. In patients with a limited number of metastatic sites, SBRT may have a role in eliminating castrate-resistant clones and possibly delaying progression to castrate-resistant disease.

  20. Critical analysis of imaging methods for the detection and diagnosis of breast cancer; Analise critica dos metodos de imagem na deteccao e diagnostico do cancer mamario

    Energy Technology Data Exchange (ETDEWEB)

    Mendonca, Maria Helena Siqueira

    1999-12-01

    Breast cancer is a significant health problem. Early diagnosis of the disease is mandatory to increase the effectiveness of the treatment, to augment the chances of cure and to permit conservative surgery. The use of imaging methods is essential in the early diagnosis of the disease. Imaging methods advantages and disadvantages, use and limitations, specificity and sensitivity are presented and discussed. (author)

  1. The PREVAIL Study: Primary Outcomes by Site and Extent of Baseline Disease for Enzalutamide-treated Men with Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer

    DEFF Research Database (Denmark)

    Evans, Christopher P; Higano, Celestia S; Keane, Thomas;

    2016-01-01

    in men with chemotherapy-naïve metastatic castration-resistant prostate cancer, with or without visceral disease, low- or high-volume bone disease, or lymph node only disease. PATIENT SUMMARY: Patients with metastatic castration-resistant prostate cancer-including those with or without visceral disease......BACKGROUND: Enzalutamide, an oral androgen receptor inhibitor, significantly improved overall survival (OS) and radiographic progression-free survival (rPFS) versus placebo in the PREVAIL trial of men with chemotherapy-naïve metastatic castration-resistant prostate cancer. OBJECTIVE: To assess...... the effects of enzalutamide versus placebo in patients from PREVAIL based on site and extent of baseline disease. DESIGN, SETTING, AND PARTICIPANTS: One thousand seven hundred and seventeen asymptomatic or minimally symptomatic patients were randomized to enzalutamide (n=872) or placebo (n=845). Subgroup...

  2. Condutas na prevenção secundária do câncer de mama e fatores associados Breast cancer's secondary prevention and associated factors

    Directory of Open Access Journals (Sweden)

    Marcelo Leal Sclowitz

    2005-06-01

    Full Text Available OBJETIVO: Avaliar a prevalência de condutas na prevenção secundária do câncer de mama e fatores associados. MÉTODOS: Foi realizado estudo transversal de base populacional na cidade de Pelotas, RS, em 2002, com amostra de 879 mulheres de 40 a 69 anos. Foram coletadas informações sobre variáveis demográficas, socioeconômicas, comportamentais, biológicas e referentes ao manejo médico. A análise estatística das variáveis foi realizada utilizando o método de regressão de Poisson. RESULTADOS: A prevalência do "hábito de realizar o auto-exame" encontrada foi de 83,5% (IC 95%: 80,9-85,9, sendo que, dessas mulheres, 80,4% (IC 95%: 77,3-83,2 o realizavam ao menos uma vez ao mês. A prevalência de "exame clínico de mamas" foi de 83,3% (IC 95%: 80,6-85,7. "Mamografia alguma vez na vida" mostrou prevalência de 70% (IC 95%: 66,8-73,0, sendo que 83,7% (IC 95%: 80,5-86,6 realizaram a última mamografia há dois anos ou menos. Das entrevistadas, 62% (IC 95%: 58,7-65,2 consultaram ginecologista ao menos uma vez no último ano. Os fatores associados a maiores prevalências das condutas na prevenção secundária do câncer de mama foram: pertencer às classes sociais mais altas; ter a maior combinação de fatores de risco para neoplasia mamária; ter história familiar de câncer de mama; fazer uso de terapia de reposição hormonal e ter sido submetida à biópsia por patologia mamária. CONCLUSÕES: As medidas preventivas para o câncer de mama vêm sendo bastante utilizadas quantitativamente; entretanto, os dados apontam para limitações em relação à sua adequação. O nível socioeconômico parece ser o principal determinante do acesso à consulta ginecológica e, conseqüentemente, às demais condutas na prevenção secundária do câncer de mama.OBJECTIVE: To evaluate the prevalence of secondary prevention of breast cancer and associated factors. METHODS: A population-based cross-sectional study was conducted in the city of

  3. Cancer

    Science.gov (United States)

    Cancer begins in your cells, which are the building blocks of your body. Normally, your body forms ... be benign or malignant. Benign tumors aren't cancer while malignant ones are. Cells from malignant tumors ...

  4. Critical analysis of the images methods in detection and diagnosis in breast cancer; Analise critica dos metodos de imagem na deteccao e diagnostico do cancer mamario

    Energy Technology Data Exchange (ETDEWEB)

    Mendonca, Maria H.S.

    1995-12-31

    The female breast cancer is a relevant health issue among female population, due its incidence and remarkable effects in the biological, psychological and social levels. Its early diagnosis is important because it allows more effective treatments and enhances changes of cure, even allowing conservative surgical procedures. To make this possible it is essential the periodic breast imaging exams. The available imaging methods to date are: mammography, ultrasonography, thermography, nuclear medicine, computed tomography and MRI. All these methods have their advantages and disadvantages, applications and limitations and some are even in experimental stages. These methods must exercised in association to become more effective. Mammography is still, beyond and doubt the elected breast exam. even though imperfect. It must be performed repeatedly at periodic intervals depending upon the intrinsic conditions of the patient. The other methods complement the mammographic findings, clearing some of them. In this paper, the imaging methods available in our environmental for detected diagnosis of the early breast cancer are analyzed with emphasis in mammography and ultrasonography. Their advantages, disadvantages, indications and limitations are discussed. (author). 205 refs., 12 figs.

  5. Câncer de mama na gravidez e quimioterapia: revisão sistemática Breast cancer during pregnancy and chemotherapy: a systematic review

    Directory of Open Access Journals (Sweden)

    Denise Leite Maia Monteiro

    2013-04-01

    Full Text Available O objetivo do estudo é estabelecer a segurança do uso da quimioterapia na gestante portadora de câncer de mama e verificar as possíveis intercorrências no feto. Para identificação de publicações foi realizada pesquisa bibliográfica nas bases de dados: MEDLINE/PubMed, LILACS, SciELO, Cochrane, Uptodate e Google acadêmico. A busca totalizou 86 artigos publicados de 2001 a 2012, que foram avaliados por dois revisores obedecendo aos critérios de exclusão e inclusão pré-estabelecidos, sendo selecionados 39 artigos para a elaboração deste estudo. Todos os quimioterápicos utilizados no tratamento do câncer de mama na gravidez pertencem à categoria D, consistindo no uso de 5-fluorouracil (F, doxorrubicina (A ou epirrubicina (E e ciclofosfamida (C ou na combinação de doxorrubicina e ciclofosfamida (AC, método seguro quando utilizado após o primeiro trimestre da gestação. Poucos estudos avaliaram o uso de taxanos (T como docetaxel (D e paclitaxel (P, não sendo demonstrado aumento da ocorrência de malformações fetais e outras complicações maternas quando utilizados no segundo e terceiro trimestres da gestação. O uso do trastuzumabe em gestantes encontra-se associado à oligodramnia e adramnia, não sendo recomendado na gravidez. Em função da quase totalidade dos estudos serem observacionais e retrospectivos, torna-se necessário a confecção de novos estudos prospectivos sobre o tema.This study aimed to establish the safety of chemotherapy use in pregnant women with breast cancer, and to find possible effects in the fetus. A search of MEDLINE/PubMed, LILACS, SciELO, Cochrane, UpToDate, and Google Scholar databases was performed to identify publications, 86 articles published from 2001 to 2012 were retrieved and evaluated by two readers in accordance predetermined exclusion and inclusion criteria; 39 articles were selected. All the chemotherapy drugs used to treat breast cancer during pregnancy belonged to class D, and

  6. Long-term Efficacy and Safety of Enzalutamide Monotherapy in Hormone-naïve Prostate Cancer

    DEFF Research Database (Denmark)

    Tombal, Bertrand; Borre, Michael; Rathenborg, Per;

    2015-01-01

    -arm study in patients with HNPC and noncastrate testosterone (≥230 ng/dl). INTERVENTION: Oral enzalutamide 160mg/d until disease progression or unacceptable toxicity. OUTCOME MEASUREMENTS AND ANALYSIS: PSA response (≥80% decline from baseline) assessed at 1 yr (49 wk) and 2 yr (97 wk). RESULTS...... patients with metastases at baseline, 13 (50%) had a complete and four (15.4%) had a partial response as best overall tumor response up to 97 wk on treatment. There was overall maintenance of total-body bone mineral density (BMD) and moderate changes in lean and fat body mass at 49 and 97 wk. The most...... cancer, enzalutamide maintained long-term reductions in prostate-specific antigen, with a minimal impact on total-body bone mineral density. TRIAL REGISTRATION: NCT01302041....

  7. Interstitial lung abnormalities in treatment-naïve advanced non-small-cell lung cancer patients are associated with shorter survival

    Energy Technology Data Exchange (ETDEWEB)

    Nishino, Mizuki, E-mail: Mizuki_Nishino@DFCI.HARVARD.EDU [Department of Radiology, Brigham and Women' s Hospital, 75 Francis St., Boston, MA 02115 (United States); Department of Imaging, Dana-Farber Cancer Institute, 450 Brookline Ave., Boston, MA 02215 (United States); Cardarella, Stephanie [Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave., Boston, MA 02215, (United States); Dahlberg, Suzanne E. [Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, 450 Brookline Ave., Boston, MA 02215 (United States); Araki, Tetsuro [Department of Radiology, Brigham and Women' s Hospital, 75 Francis St., Boston, MA 02115 (United States); Lydon, Christine; Jackman, David M.; Rabin, Michael S. [Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave., Boston, MA 02215, (United States); Hatabu, Hiroto [Department of Radiology, Brigham and Women' s Hospital, 75 Francis St., Boston, MA 02115 (United States); Johnson, Bruce E. [Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave., Boston, MA 02215, (United States)

    2015-05-15

    Highlights: • Interstitial lung abnormalities were present in 14% of stage IV NSCLC patients. • ILA was more common in older patients with heavier smoking history. • ILA was associated with shorter survival after adjusting for smoking and therapy. • ILA could be an additional independent marker for survival in advanced NSCLC. - Abstract: Objective: Interstitial lung diseases are associated with increased risk of lung cancer. The prevalence of ILA at diagnosis of advanced non-small-cell lung cancer (NSCLC) and its impact on overall survival (OS) remain to be investigated. Materials and method: The study included 120 treatment-naïve stage IV NSCLC patients (53 males, 67 females). ILA was scored on CT prior to any systemic therapy using a 4-point scale [0 = no evidence of ILA, 1 = equivocal for ILA, 2 = suspicious for ILA, 3 = ILA] by a sequential reading method previously reported. ILA scores of 2 or 3 indicated the presence of ILA. Results: ILA was present in 17 patients (14%) with advanced NSCLC prior to any treatment (score3: n = 2, score2: n = 15). These 17 patients were significantly older (median age: 69 vs. 63, p = 0.04) and had a heavier smoking history (median: 40 vs. 15.5 pack-year, p = 0.003) than those with ILA score 0 or 1. Higher ILA scores were associated with shorter OS (p = 0.001). Median OS of the 17 patients with ILA was 7.2 months [95%CI: 2.9–9.4] compared to 14.8 months [95%CI: 11.1–18.4] in patients with ILA score 0 or 1 (p = 0.002). In a multivariate model, the presence of ILA remained significant for increased risk for death (HR = 2.09, p = 0.028) after adjusting for first-line systemic therapy (chemotherapy, p < 0.001; TKI, p < 0.001; each compared to no therapy) and pack years of smoking (p = 0.40). Conclusion: Radiographic ILA was present in 14% of treatment-naïve advanced NSCLC patients. Higher ILA scores were associated with shorter OS, indicating that ILA could be a marker of shorter survival in advanced NSCLC.

  8. Depression and anxiety levels in therapy-na(i)ve patients with inflammatory bowel disease and cancer of the colon

    Institute of Scientific and Technical Information of China (English)

    Branislav R Filipovi(c); Branka F Filipovi(c); Mirko Kerkez; Nikola Milini(c); Tomislav Ran(d)elovi(c)

    2007-01-01

    AIM: To assess whether depression and anxiety are more expressed in patients with the first episode of inflammatory bowel disease (IBD) than in individuals with newly discovered cancer of the colon (CCa).METHODS: A total of 32 patients with IBD including 13males and 19 females, aged 27 to 74, and 30 patients with CCa including 20 males and 10 females, aged 39-78,underwent a structured interview, which comprised Hamilton's Depression Rating Inventory, Hamilton's Anxiety Rating Inventory and Paykel's Stressful Events Rating Scale.RESULTS: Patients of the IBD group expressed both depression and anxiety. Depressive mood, sense of guilt, psychomotor retardation and somatic anxiety were also more pronounced in IBD patients. The discriminant function analysis revealed the total depressive score was of high importance for the classification of a newly diagnosed patient into one of the groups.CONCLUSION: Newly diagnosed patients with IBD have higher levels of depression and anxiety. Moreover, a psychiatrist in the treatment team is advisable from the beginning.

  9. Endocrine sequelae after radiotherapy in childhood and adolescence; Sequelas endocrinas da radioterapia no tratamento do cancer na infancia e adolescencia

    Energy Technology Data Exchange (ETDEWEB)

    Couto-Silva, Ana Claudia; Adan, Luis Fernando [Universidade Federal da Bahia, Salvador, BA (Brazil); Brauner, Raja [Paris-5 Univ. (France)

    2005-10-15

    Radiotherapy may result in endocrine abnormalities, osteoporosis, obesity and neurological sequelae in patients treated for cancer. In the hypothalamo-pituitary area, GH deficiency is the most frequent complication. The frequency, delay of appearance and severity of GH deficiency depend most on the dose delivered during cranial irradiation but variables as age at treatment and fractionation schedule may play an important role as well. Other hypothalamo-pituitary dysfunctions are also dose-dependent. Low dose cranial irradiation may induce precocious or early puberty, while high doses are related to gonadotropin deficiency. Endocrine complications due to extracranial irradiation such as gonadal or thyroid abnormalities are described. In spite of normal GH secretion, linear growth may be impaired by bone lesions secondary to craniospinal or total body irradiation. Results on final height have been optimized by better indicators of GH therapy associated with adequate treatment of early or precocious puberty. The purpose of this review is to explore the late endocrine sequelae of radiotherapy. (author)

  10. Preparation and clinical use of 18F-NaF in bone metastasis from lung cancer%18F-NaF的合成及其在肺癌骨转移中的临床应用

    Institute of Scientific and Technical Information of China (English)

    李彦生; 王俊起; 刘磊; 高硕

    2006-01-01

    目的合成并检测18F-NaF;比较99Tcm-亚甲基二膦酸盐(MDP)全身骨显像与18F-NaFPET/CT骨显像对诊断肺癌骨转移的价值.方法用MINItrace回旋加速器通过核反应18O(p,n)18F生产18F-F,用离子交换法合成18F-NaF并进行质控检测.对10例已行99Tcm-MDP全身骨显像的肺癌患者行18F-NaF PET/CT检查,对两者图像进行比较.结果18F-NaF注射液符合要求.18F-NaF PET/CT骨显像探测到99Tcm-MDP骨显像发现的所有病灶,并探测到后者未发现的8个病灶,使99Tcm-MDP骨显像不确定诊断数减少.结论18F-NaF PET/CT诊断肺癌骨转移准确性更高,可作为99Tcm-MDP骨显像的补充.

  11. Behavior of gastric cancer in Brazilian population Comportamento do câncer gástrico na população brasileira

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Jacob

    2009-03-01

    Full Text Available BACKGROUND: Gastric cancer (GC is a predominately male disease. Usually for every female that suffers from this condition there are two males and occurred an increase in the number of females in last decades. Brazil is poor in data about this issue. AIM: To verify if in Brazil it happened: a a change in the gender ratio and on the average age of the patients; b an increase in the number of patients with 70 years of age or more suffering from this disease; c changes in the gender ratio and in the average age in the several gastric locations during the period of study. METHODS: The medical history of patients diagnosed with primary gastric adenocarcinoma, between 1971 and 1998 were obtained at Hospital das Clínicas of the University of São Paulo, São Paulo, SP, Brazil. Exclusion criteria were: patients suffering from a non epithelial gastric malignancy; adenocarcinoma from the intestinal metaplasia in the distal esophagus invading the proximal stomach and patients submitted to a gastric resection, due to a benign or malignant tumor during the last five years prior to the surgical procedure analyzed in this study. The patients were divided into 10 years age groups and also divided in three groups, according to their ages and time intervals. Interrelationships between gender and age, and with tumor´s location on gastric wall were analyzed. RESULTS: From 1971 to 1998, 1578 patients with GC were hospitalized. Among them, 1021 were treated with gastric resection, corresponding to 64.7% of all patients. There was an increase in the proportion of patients older than 70 years, and decrease between 41 and 70 years. There was no statistical significant difference among the average ages and the different locations. There were significant differences for the locations favoring proximal third and stump, both more prevalent in males. CONCLUSIONS: a Occurred modifications in the ratio between genders: greater number of women and an increase in the number of

  12. Enzalutamide in Men with Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer: Extended Analysis of the Phase 3 PREVAIL Study.

    Science.gov (United States)

    Beer, Tomasz M; Armstrong, Andrew J; Rathkopf, Dana; Loriot, Yohann; Sternberg, Cora N; Higano, Celestia S; Iversen, Peter; Evans, Christopher P; Kim, Choung-Soo; Kimura, Go; Miller, Kurt; Saad, Fred; Bjartell, Anders S; Borre, Michael; Mulders, Peter; Tammela, Teuvo L; Parli, Teresa; Sari, Suha; van Os, Steve; Theeuwes, Ad; Tombal, Bertrand

    2017-02-01

    Enzalutamide significantly improved radiographic progression-free survival (rPFS) and overall survival (OS) among men with chemotherapy-naïve metastatic castration-resistant prostate cancer at the prespecified interim analysis of PREVAIL, a phase 3, double-blind, randomized study. We evaluated the longer-term efficacy and safety of enzalutamide up to the prespecified number of deaths in the final analysis, which included an additional 20 mo of follow-up for investigator-assessed rPFS, 9 mo of follow-up for OS, and 4 mo of follow-up for safety. Enzalutamide reduced the risk of radiographic progression or death by 68% (hazard ratio [HR] 0.32, 95% confidence interval [CI] 0.28-0.37; p<0.0001) and the risk of death by 23% (HR 0.77, 95% CI 0.67-0.88; p=0.0002). Median investigator-assessed rPFS was 20.0 mo (95% CI 18.9-22.1) in the enzalutamide arm and 5.4 mo (95% CI 4.1-5.6) in the placebo arm. Median OS was 35.3 mo (95% CI 32.2-not yet reached) in the enzalutamide arm and 31.3 mo (95% CI 28.8-34.2) in the placebo arm. At the time of the OS analysis, 167 patients in the placebo arm had crossed over to receive enzalutamide. The most common adverse events in the enzalutamide arm were fatigue, back pain, constipation, and arthralgia. This final analysis of PREVAIL provides more complete assessment of the clinical benefit of enzalutamide. PREVAIL is registered on ClinicalTrials.gov as NCT01212991.

  13. Cancer

    Science.gov (United States)

    ... uses a surgical tool to remove the tumor.Mohs' surgery. Layers of cancer cells are removed one ... usually have not been approved by the U.S. Food and Drug Administration (FDA). The medicine may have ...

  14. Prevenção do tromboembolismo na cirurgia do câncer do aparelho digestivo Thromboembolism prevention in surgery of digestive cancer

    Directory of Open Access Journals (Sweden)

    Osvaldo Malafaia

    2012-12-01

    Full Text Available RACIONAL: Tromboembolismo venoso é complicação frequente após tratamento cirúrgico em geral e, de um modo especial, na condução terapêutica do câncer. A cirurgia do aparelho digestivo tem sido referida como potencialmente indutora desta complicação. Os pacientes com câncer digestivo, têm risco substancialmente aumentado de iniciarem ou de terem recorrência de processo tromboembólico. OBJETIVO: Oferecer aos cirurgiões que atuam na cirurgia digestiva e geral orientação segura sobre como efetuar a tromboprofilaxia dos pacientes que necessitam de operações no tratamento de doenças malignas digestivas. MÉTODOS: A Diretriz foi baseada a partir da elaboração de 15 questões clínicas relevantes e relacionadas ao risco, tratamento e prognóstico do paciente submetido ao tratamento cirúrgico do câncer do aparelho digestivo. Elas focaram tanto os eventos tromboembólicos associados às operações quanto os aspectos relacionados à sua profilaxia. As questões foram estruturadas por meio do P.I.C.O. (Paciente, Intervenção ou Indicador, Comparação e Outcome, permitindo gerar estratégias de busca da evidência nas principais bases primárias de informação científica (Medline/Pubmed, Embase, Lilacs/Scielo, Cochrane Library, Premedline via OVID. Também foi realizada busca manual da evidência e de teses (BDTD e IBICT. A evidência recuperada foi selecionada a partir da avaliação crítica utilizando instrumentos (escores discriminatórios de acordo com a categoria da questão: risco, terapêutica e prognóstico (JADAD para Ensaios Clínicos Randomizados e New Castle Otawa Scale para estudos não randômicos. Após definir os estudos potenciais para sustento das recomendações, eles foram selecionados pela força da evidência e grau de recomendação segundo a classificação de Oxford, incluindo a evidência disponível de maior força. RESULTADOS: Foram avaliados 53.555 trabalhos pelo título e/ou resumo. Deste total

  15. Na+/H+ exchanger NHE1 regulation modulates metastatic potential and epithelial-mesenchymal transition of triple-negative breast cancer cells.

    Science.gov (United States)

    Amith, Schammim Ray; Wilkinson, Jodi Marie; Fliegel, Larry

    2016-04-19

    In triple-negative breast cancer (TNBC), the high recurrence rate, increased invasion and aggressive metastatic formation dictate patient survival. We previously demonstrated a critical role for the Na+/H+ exchanger isoform 1 (NHE1) in controlling metastasis of triple-negative cells. Here, we investigated the effect of changes to three regulatory loci of NHE1. Two via the Ras/Raf/ERK/p90RSK pathway: p90RSK/14-3-3 (S703A) and ERK1/2 (S766,770,771A, SSSA) and a third via a calmodulin-binding domain (K641,R643,645,647E, 1K3R4E). MDA-MB-231 cells with a mutation at the p90RSK site (S703A-NHE1) changed from a wild-type mesenchymal morphology to a smaller epithelial-like phenotype with a loss of expression of mesenchymal marker vimentin. S703A cells also had reduced metastatic potential and markedly decreased rates of migration, invasion, spheroid growth, anchorage-dependent and soft agar colony formation. Similarly, BI-D1870, a specific inhibitor of p90RSK, significantly inhibited the metastatic potential of highly invasive MDA-MB-231 and moderately invasive MDA-MB-468 TNBC cells, but was minimally effective in non-invasive Hs578T TNBC cells. In contrast, invasion and spheroid growth were unaffected in cells containing NHE1 with mutations interfering with its activation by ERK1/2 (SSSA), though rates of migration and colony formation were reduced. Cells with a constitutive activation of NHE1 via the 1K3R4E mutation exhibited higher rates of migration, invasion, and spheroid growth. Taken together, our data demonstrate the critical role of NHE1 in metastasis, and suggest a novel link between NHE1 and the expression and cytosolic organization of vimentin, a key factor in epithelial-mesenchymal transition, that is dependent on p90RSK/14-3-3-mediated activation of the exchanger.

  16. Doxorubicin-loaded NaYF4:Yb/Tm-TiO2 inorganic photosensitizers for NIR-triggered photodynamic therapy and enhanced chemotherapy in drug-resistant breast cancers.

    Science.gov (United States)

    Zeng, Leyong; Pan, Yuanwei; Tian, Ying; Wang, Xin; Ren, Wenzhi; Wang, Shouju; Lu, Guangming; Wu, Aiguo

    2015-07-01

    The combination therapy has exhibited important potential for the treatment of cancers, especially for drug-resistant cancers. In this report, bi-functional nanoprobes based on doxorubicin (DOX)-loaded NaYF4:Yb/Tm-TiO2 inorganic photosensitizers (FA-NPs-DOX) were synthesized for in vivo near infrared (NIR)-triggered inorganic photodynamic therapy (PDT) and enhanced chemotherapy to overcome the multidrug resistance (MDR) in breast cancers. Using the up-conversion luminescence (UCL) performance of NaYF4:Yb/Tm converting near-infrared (NIR) into ultraviolent (UV) lights, reactive oxygen species (ROS) were triggered from TiO2 inorganic photosensitizers for PDT under the irradiation of a 980 nm laser, by which the deep-penetration and low photo-damage could be reached. Moreover, nanocarrier delivery and folic acid (FA) targeting promoted the cellular uptake, and accelerated the release of DOX in drug-sensitive MCF-7 and resistant MCF-7/ADR cells. The toxicity assessment in vitro and in vivo revealed the good biocompatibility of the as-prepared FA-NPs-DOX nanocomposites. By the combination of enhanced chemotherapy and NIR-triggered inorganic PDT, the viability of MCF-7/ADR cells could decrease by 53.5%, and the inhibition rate of MCF-7/ADR tumors could increase up to 90.33%, compared with free DOX. Therefore, the MDR of breast cancers could be obviously overcome by enhanced chemotherapy and NIR-triggered inorganic PDT of FA-NPs-DOX nanocomposites under the excitation of a 980 nm laser.

  17. Determination of the frequency of polymorphisms in genes related to the genome stability maintenance of the population residing at Monte Alegre, PA (Brazil) municipality; Determinacao da frequencia de polimorfismos em genes relacionados a manutencao da estabilidade do genoma na populacao residente no municipio de Monte Alegre, PA

    Energy Technology Data Exchange (ETDEWEB)

    Hozumi, Cristiny Gomes

    2010-07-01

    The human exposure to ionizing radiation coming from natural sources is an inherent feature of human life on earth, for man and all living things have always been exposed to these sources. Ionizing radiation is a known genotoxic agent which can affect the genomic stability and genes related to DNA repair may play a role when they have committed certain polymorphism. This study aimed to analyze the frequency of polymorphisms (SNPs) in genes of DNA repair and cell cycle control: hOGG1 (Ser326Cys), XRCC3 (Thr241 Met) and p53 (Arg72Pro) in saliva samples from a population located Monte Alegre, state of Para were collected in August 2008 and 40 samples of men and 46 samples of women, adding a total of 86 samples. By RFLP was determined the frequency of homozygous genotypes and / or heterozygous for polymorphic genes. The I)OGG1 gene was 5% of the allele 326Cys, XRCC3 gene found about 21 % of the allele 241 Met and p53 gene showed 40.8% of the 72Pro allele. And the genotype frequencies of individuals for the three genes were 91.04%, 88.06% and 59.7% for homozygous wild genotype, 5.97%, 11.94% and 22.39% for heterozygote genotype and 2,99%, zero and 17:91% for homozygous polymorphic hOGG1 genes respectively, XRCC3, p53. These values are similar to those found in previous studies. The influence of these polymorphisms, which are involved in DNA repair and consequent genotoxicity induced by radiation depends on dose and exposure factors such as smoking, which is statistically a factor in public health surveillance in the region. This study gathered information and molecular epidemiology in Monte Alegre, that help to characterization of local population. (author)

  18. CANCER

    Directory of Open Access Journals (Sweden)

    N. Kavoussi

    1973-09-01

    Full Text Available There are many carcinogenetic elements in industry and it is for this reason that study and research concerning the effect of these materials is carried out on a national and international level. The establishment and growth of cancer are affected by different factors in two main areas:-1 The nature of the human or animal including sex, age, point and method of entry, fat metabolism, place of agglomeration of carcinogenetic material, amount of material absorbed by the body and the immunity of the body.2 The different nature of the carcinogenetic material e.g. physical, chemical quality, degree of solvency in fat and purity of impurity of the element. As the development of cancer is dependent upon so many factors, it is extremely difficult to determine whether a causative element is principle or contributory. Some materials are not carcinogenetic when they are pure but become so when they combine with other elements. All of this creates an industrial health problem in that it is almost impossible to plan an adequate prevention and safety program. The body through its system of immunity protects itself against small amounts of carcinogens but when this amount increases and reaches a certain level the body is not longer able to defend itself. ILO advises an effective protection campaign against cancer based on the Well –equipped laboratories, Well-educated personnel, the establishment of industrial hygiene within factories, the regular control of safety systems, and the implementation of industrial health principles and research programs.

  19. Regulation of demethylation and re-expression of RASSF1A gene in gastric cancer cell lines by combined treatment of 5-Aza-CdR and NaB

    Institute of Scientific and Technical Information of China (English)

    Wen-Jing Shen; Dong-Qiu Dai; Yue Teng; Hong-Bo Liu

    2008-01-01

    AIM: To investigate the changes of methylation state and expression of RASSF1A gene in human gastric cancer cell lines SGC7901 and BGC823 which were treated in vitro with demethlylating agent 5-Aza-CdR in combination with histone deacetylase inhibitor NaB.METHODS: After SGC7901 and BGC823 cells were treated with 5-Aza-CdR and/or NaB, the methylation state of RASSF1A gene was detected by methylation-specific PCR, and the changes in expression of mRNA and protein level of RASSF1A gene were observed by RT-PCR and Western-blotting before and after drug treatment.RESULTS: Hypermethylation was detected in the promoter region of RASSF1A gene in both SGC7901 and BGC823 cells, and there was no expression of this gene at both mRNA and protein level. After treatment with 5-Aza-CdR, demethylation occurred in the promoter region of RASSF1A gene, which subsequently induced re-expression of this gene. The treatment with NaB alone showed no effect on the methylation state and expression of RASSF1A gene. The combined treatment of 5-Aza-CdR and NaB induced complete demethylation of RASSF1A gene, leading to a significantly higher re-expression of the mRNA and protein of RASSF1A than those treated with 5-Aza-CdR alone (P < 0.05).CONCLUSION: Hypermethylation in the promoter region is related to inactivation of RASSF1A gene in human gastric cancer cell lines SGC7901 and BGC823, while demethlylating agent 5-Aza-CdR can reverse the methylation state of RASSF1A gene and induce itsre-expression. Histone deacetylase inhibitor NaB had a synergistic effect with 5-Aza-CdR in both demethylation and gene transcriptional regulation.(c) 2008 WJG. All rights reserved.

  20. Adiposity In Childhood Cancer Survivors: Insights Into Obesity Physiopathology [adiposidade Em Pacientes Tratados Por Câncer Na Infância: Entendendo A Fisiopatologia Da Obesidade

    OpenAIRE

    Siviero-Miachon, Adriana Aparecida; Spinola-Castro, Angela Maria; Guerra-Junior,Gil

    2009-01-01

    As childhood cancer treatment has become more effective, survival rates have improved, and a number of complications have been described while many of these patients reach adulthood. Obesity is a well-recognized late effect, and its metabolic effects may lead to cardiovascular disease. Currently, studies concerning overweight have focused on acute lymphocytic leukemia and brain tumors, since they are at risk for hypothalamic-pituitary axis damage secondary to cancer therapies (cranial irradia...

  1. 18F-NaF PET-CT与血清肿瘤标志物联合检测对肺癌骨转移早期诊断的价值%Value of 18F-NaF PET-CT and serum tumor markers in the joint detection of bone metastases in recently diagnosed lung cancer patients

    Institute of Scientific and Technical Information of China (English)

    王明霜; 周凡; 甘西伦; 谭蓓蓓

    2015-01-01

    目的:探讨18F-NaF PET-CT与血清肿瘤标志物CEA、CYFRA21-1、NSE联合检测对肺癌骨转移患者早期诊断的临床意义。方法:选取46例来我院就诊,通过临床、CT、MRI等确诊为肺癌骨转移患者,分别于行18F-NaF PET-CT检查同时采取静脉血行血清CEA、CYFRA21-1、NSE检测,得到的最终诊断进行比较,分析两种检查联合检测在肺癌骨转移患者早期诊断中的临床意义。结果:46例患者18F-NaF PET-CT检查的SUVmax平均值为8.81±4.54,CEA平均值为37.45±42.57,CYFRA21-1平均值为32.30±42.66,NSE平均值为50.12±38.45。46例阳性患者,18F-NaF PET-CT检查出44例,灵敏度为93.40%,特异性为91.37%,准确性为93.50%;三种血清肿瘤标志物联合检测诊断肺癌的灵敏度分别为83.49%,特异性为70.52%,准确性为90.99%;两种检查联合诊断的灵敏度为96.85%,特异性为97.43%,准确性为98.33%。结论:18F-NaF PET-CT对肺癌骨转移早期患者诊断的灵敏度和准确性较血清CEA、CYFRA21-1、NSE检测高,但血清CEA、CYFRA21-1、NSE对其诊断也具有一定的价值,对前者检查可以起到协助补充的作用,两者联合应用对于肺癌骨转移早期患者的早期诊断具有重要的临床意义。%ObjectiveTo explore the joint detection value of 18F-NaF PET-CT and serum CEA,CYFRA21-1,and NSE in the diagnosis of bone metastases in recently diagnosed lung cancer patients. Methods46 cases of confirmed bone metastases of recently diagnosed lung cancer were selected, 18F-NaF PET-CT and serum CEA, CYFRA21-1,and NSE detection were performed at the same time, and their value in early detecting the bone metastasis was studied. Results In 46 cases, the SUV max of 18F-NaF PET-CT was 8.81 ± 4.54, serum CEA was 37.45±42.57,serum CYFRA21-1 was 32.30±42.66, seram NSE was 50.12±38.45. The sensitivity of 18F-NaF PET - CT examination was 93.40%, specificity was 91.37%, the diagnostic accuracy was 93

  2. Preservação do Nervo Intercostobraquial na Linfadenectomia Axilar por Carcinoma de Mama Preservation of Intercostobrachial Nerve during Axillary Clearance for Breast Cancer

    Directory of Open Access Journals (Sweden)

    Renato Zocchio Torresan

    2002-05-01

    Full Text Available Objetivos: avaliar a associação entre a preservação do nervo intercostobraquial e a sensibilidade dolorosa do braço, tempo de cirurgia e número de linfonodos dissecados em pacientes submetidas à linfadenectomia axilar por carcinoma de mama. Métodos: foi realizado um estudo de intervenção, tipo ensaio clínico, randomizado e duplo-cego com 85 pacientes atendidas no Centro de Atenção Integral à Saúde da Mulher da Universidade Estadual de Campinas, no período de janeiro de 1999 a julho de 2000. As pacientes foram divididas aleatoriamente em dois grupos, conforme a intenção da preservação ou não do nervo intercostobraquial. As cirurgias foram realizadas sempre por dois dos pesquisadores, utilizando a mesma técnica. As avaliações pós-operatórias foram feitas com 2 dias, 40 dias e após 3 meses, por um dos pesquisadores que não havia participado das cirurgias. A sensibilidade dolorosa no braço foi avaliada mediante emprego de questionário específico e pelo exame físico neurológico, sempre correlacionado com o membro contralateral. Para a análise estatística foram utilizados os testes t de Student e exato de Fisher. Resultados: a técnica cirúrgica de preservação do nervo intercostobraquial foi factível em 100% dos casos, associando-se a diminuição significativa nas alterações de sensibilidade dolorosa do braço, em comparação com as pacientes que tiveram o nervo intercostobraquial seccionado. Após 3 meses, na avaliação subjetiva 61% das pacientes encontravam-se assintomáticas no grupo da preservação e 28,6% no grupo da secção (pPurpose: to evaluate the relationdhip between preservation of the intercostobrachial nerve and pain sensitivity of the arm, total time of the surgery, and number of dissected nodes in patients submitted to axillary lymphadenectomy due to breast cancer. Methods: an intervention, prospective, randomized and double-blind study was performed on 85 patients assisted at the State

  3. Impact of Bone-targeted Therapies in Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer Patients Treated with Abiraterone Acetate: Post Hoc Analysis of Study COU-AA-302

    Science.gov (United States)

    Saad, Fred; Shore, Neal; Van Poppel, Hendrik; Rathkopf, Dana E.; Smith, Matthew R.; de Bono, Johann S.; Logothetis, Christopher J.; de Souza, Paul; Fizazi, Karim; Mulders, Peter F.A.; Mainwaring, Paul; Hainsworth, John D.; Beer, Tomasz M.; North, Scott; Fradet, Yves; Griffin, Thomas A.; De Porre, Peter; Londhe, Anil; Kheoh, Thian; Small, Eric J.; Scher, Howard I.; Molina, Arturo; Ryan, Charles J.

    2016-01-01

    Background Metastatic castration-resistant prostate cancer (mCRPC) often involves bone, and bone-targeted therapy (BTT) has become part of the overall treatment strategy. Objective Investigation of outcomes for concomitant BTT in a post hoc analysis of the COU-AA-302 trial, which demonstrated an overall clinical benefit of abiraterone acetate (AA) plus prednisone over placebo plus prednisone in asymptomatic or mildly symptomatic chemotherapy-naïve mCRPC patients. Design, setting, and participants This report describes the third interim analysis (prespecified at 55% overall survival [OS] events) for the COU-AA-302 trial. Intervention Patients were grouped by concomitant BTT use or no BTT use. Outcome measurements and statistical analysis Radiographic progression-free survival and OS were coprimary end points. This report describes the third interim analysis (prespecified at 55% OS events) and involves patients treated with or without concomitant BTT during the COU-AA-302 study. Median follow-up for OS was 27.1 mo. Median time-to-event variables with 95% confidence intervals (CIs) were estimated using the Kaplan-Meier method. Adjusted hazard ratios (HRs), 95% CIs, and p values for concomitant BTT versus no BTT were obtained via Cox models. Results and limitations While the post hoc nature of the analysis is a limitation, superiority of AA and prednisone versus prednisone alone was demonstrated for clinical outcomes with or without BTT use. Compared with no BTT use, concomitant BTT significantly improved OS (HR 0.75; p = 0.01) and increased the time to ECOG deterioration (HR 0.75; p < 0.001) and time to opiate use for cancer-related pain (HR 0.80; p = 0.036). The safety profile of concomitant BTT with AA was similar to that reported for AA in the overall intent-to-treat population. Osteonecrosis of the jaw (all grade 1/2) with concomitant BTT use was reported in <3% of patients. Conclusions AA with concomitant BTT was safe and well tolerated in men with chemotherapy-na

  4. Câncer e o sujeito em psicoterapia: horizontes de trabalho na perspectiva existencialista de Jean-Paul Sartre Cancer and the subject in psychotherapy: work horizons from the Jean-Paul Sartre existentialist perspective

    Directory of Open Access Journals (Sweden)

    Fabíola Langaro

    2012-12-01

    Full Text Available Este artigo apresenta o relato de um processo psicoterápico realizado com Sofia, uma mulher de 36 anos em tratamento médico para um câncer de mama. Com base na teoria existencialista de Jean-Paul Sartre, compreendeu-se a doença como geradora de mudanças significativas em seu projeto de ser pelas alterações provocadas em suas relações e, consequentemente, em sua experiência de ser quem é. A partir disto, o objetivo principal do processo foi viabilizar Sofia a partir das diferentes condições e horizontes existenciais impostos pela doença, sem esquecer que experiências de sofrimento a atingiram em toda sua história e complexidade e não somente aquelas circunscritas à ocorrência do câncer. Finalizado o processo psicoterápico, considera-se que foi possível reorganizar seu projeto de ser, na medida em que se possibilitou a ela compreender aspectos importantes da trajetória que havia percorrido e ainda de suas possibilidades concretas no presente e para seu futuro.This article presents a report of a psychotherapy process conducted with Sofia, a woman of 36 years old, carrying through a medical treatment for breast cancer. Based on the existentialist theory of Jean-Paul Sartre, the cancer was considered as provoking significant changes in her being project, mainly caused by changes in her relationships and, consequently, in her experience of being who she was. From this, the main objective of the process was feasible Sofia from different horizons and existential conditions imposed by the disease, without forgetting that reached the experiences of suffering in all its history and complexity, and not only limited to the occurrence of cancer. Finished the psychotherapeutic process, it is considered that it was possible to rearrange Sofia being project, as it enabled her to understand important aspects of the path she had trod and yet her specific possibilities in the present and her future.

  5. Genetic polymorphisms and metabolism of endocrine disruptors in cancer susceptibility Polimorfismos genéticos e metabolismo dos desreguladores endócrinos na suscetibilidade ao câncer

    Directory of Open Access Journals (Sweden)

    Ana Hatagima

    2002-04-01

    Full Text Available Epidemiological studies have estimated that approximately 80% of all cancers are related to environmental factors. Individual cancer susceptibility can be the result of several host factors, including differences in metabolism, DNA repair, altered expression of tumor suppressor genes and proto-oncogenes, and nutritional status. Xenobiotic metabolism is the principal mechanism for maintaining homeostasis during the body's exposure to xenobiotics. The balance of xenobiotic absorption and elimination rates in metabolism can be important in the prevention of DNA damage by chemical carcinogens. Thus the ability to metabolize and eliminate xenobiotics can be considered one of the body's first protective mechanisms. Variability in individual metabolism has been related to the enzymatic polymorphisms involved in activation and detoxification of chemical carcinogens. This paper is a contemporary literature review on genetic polymorphisms involved in the metabolism of endocrine disruptors potentially related to cancer development.Estudos epidemiológicos estimam que cerca de 80% dos cânceres estão relacionados a fatores ambientais. A suscetibilidade individual ao câncer pode resultar de vários fatores relacionados ao metabolismo de xenobióticos, reparo do DNA, expressão de genes supressores de tumor e protoncogenes e estado nutricional. O metabolismo é o principal mecanismo para manter a homeostasia durante a exposição dos organismos aos xenobióticos. O equilíbrio das taxas de absorção e eliminação dos xenobióticos tem um papel importante na prevenção de danos no DNA, provocados por carcinógenos químicos. Sendo assim, a habilidade de metabolizar e eliminar os xenobióticos pode ser considerada uma das primeiras linhas de defesa dos organismos. Variações no metabolismo individual têm sido relacionadas aos polimorfismos enzimáticos, envolvidos na ativação e desintoxicação de carcinógenos químicos. Neste trabalho, é realizada

  6. A methodology to establish the appearance of cancer cases due to radiation dose in compressed breast; Uma metodologia para comprovar o aparecimento de casos de cancer devido a dose de radiacao na mama comprimida

    Energy Technology Data Exchange (ETDEWEB)

    Feital, Joao Carlos Da Silva; Delgado, Jose Ubiratan; Peixoto, Jose Guilherme P.; Fonseca, Hugo Geraldo Da, E-mail: jfeital@ird.gov.br, E-mail: delgado@ird.gov.br, E-mail: guilherm@ird.gov.br, E-mail: hfonseca@ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2013-10-01

    It is known that more than 20% of the world's population will contract some type of cancer. In Brazil, with the exception of skin cancer (non melanoma) the breast cancer ranks first among the higher frequency of tumours among women and in general, although the methods of detection are advancing in the year 2010 took place about 13 thousand deaths in about 50,000 cases, probably due to late detection of these neoplasm. New cases of breast cancer in a given population can be proven from absorbed dose quantity, calculated for the compressed breast, due to the risk by means of exposure to x rays in this radiodiagnostic practices. Methodology: Exposures were held in an ionization chamber and the other quantities required were obtained to the screen-film equipment of mammography. Results: Also experimental results were of compressed breast an equivalent dose of ( 1.82 mSv {+-} 0.2%) or (3.64 mSv {+-} 0.2%) for both projections, i.e. medium lateral oblique and cranio caudal. The experimental value obtained here is consistent with the calculated results and published in the literature for analog and CR equipment. Conclusion: From the result of dose equivalent in the breast, one can say that there will be effectively attesting as to the appearance of new cases of cancer if approximately 80 million women are exposed to radiation emitted by mammographers. (author)

  7. The predictive value of ERG protein expression for development of castration-resistant prostate cancer in hormone-naïve advanced prostate cancer treated with primary androgen deprivation therapy

    DEFF Research Database (Denmark)

    Berg, Kasper Drimer; Røder, Martin A; Thomsen, Frederik B;

    2015-01-01

    BACKGROUND: Biomarkers predicting response to primary androgen deprivation therapy (ADT) and risk of castration-resistant prostate cancer (CRPC) is lacking. We aimed to analyse the predictive value of ERG expression for development of CRPC. METHODS: In total, 194 patients with advanced and....../or metastatic prostate cancer (PCa) treated with first-line castration-based ADT were included. ERG protein expression was analysed in diagnostic specimens using immunohistochemistry (anti-ERG, EPR3864). Time to CRPC was compared between ERG subgroups using multiple cause-specific Cox regression stratified...

  8. Lack of prognostic significance of p16 and p27 after radical prostatectomy in hormone-naïve prostate cancer

    Directory of Open Access Journals (Sweden)

    Vlachostergios Panagiotis J

    2012-01-01

    Full Text Available Abstract Background Loss of normal cell cycle control is an early event in the evolution of cancer. The expression of cyclin-dependent kinase (CDK inhibitors p16 and p27 has been previously associated with progression of prostate cancer (PC. 70 patients diagnosed with early stage PCwere treated with radical prostatectomy (RP at our institution and their tumor specimens were immunohistochemically evaluated for expression of p16 and p27. Available clinical data of time to PSA recurrence were correlated with the examined parameters and combined with pre-operative PSA level, Gleason score and pathological TNM (pT stage assessment. Results Nuclear overexpression of p16 was not associated with time to biochemical failure (BF (p = 0.572. Same was the case for nuclear p27 overexpression (p = 1.000. Also, no significant correlations were found between either p16 or p27, and pre-operative PSA level, pT stage and Gleason grade. pT stage emerged as the only independent prognostic factor for biochemical recurrence (p = 0.01. Conclusions These data question previously reported data supporting the prognostic relevance of both p16 and p27 proteins in early PC.

  9. Câncer de mama: mortalidade crescente na Região Sul do Brasil entre 1980 e 2002 Increase in breast cancer mortality in Southern Brazil from 1980 to 2002

    Directory of Open Access Journals (Sweden)

    Andrea T. Cadaval Gonçalves

    2007-08-01

    Full Text Available O câncer de mama é apontado como o tipo de câncer mais prevalente no mundo. No Brasil, as taxas de mortalidade por câncer de mama continuam elevadas, observando-se diferenças inter-regionais. Foi realizado um estudo ecológico de série temporal (1980-2002 na Região Sul, com dados anuais do Departamento de Informação e Informática do SUS (DATASUS, para avaliar o comportamento do coeficiente de mortalidade por câncer de mama, padronizado por idade. Utilizou-se regressão linear simples e múltipla para estimar as taxas de mortalidade e as diferenças entre os três Estados. O Rio Grande do Sul parte de um patamar mais elevado e apresenta maior taxa média de mortalidade (14,45, sendo significativamente diferente (p Breast cancer is the most prevalent form of cancer in the world. Breast cancer mortality rates are high in Brazil and show striking variations between geographic regions. A time-trend ecological study was performed in Southern Brazil from 1980 to 2002. Data were collected from the Mortality Information System (Ministry of Health to assess age-standardized mortality rates. Linear regression for mortality time-trend analysis and multiple regression for mortality differences among three States were calculated. The highest mean mortality rate (14.45 was observed in Rio Grande do Sul, significantly greater (p < 0.001 than in Santa Catarina (8.93 and Paraná (9.95. An annual increase of 0.47 in the mortality rate was observed in the three States of Southern Brazil. According to these results, the South of Brazil and especially the State of Rio Grande do Sul showed a significant upward trend in breast cancer mortality. Continued efforts are needed to help explain these numbers and reverse the present situation.

  10. Epidermal growth factor upregulates motility of Mat-LyLu rat prostate cancer cells partially via voltage-gated Na+ channel activity

    Science.gov (United States)

    Ding, Yanning; Brackenbury, William J.; Onganer, Pinar U.; Montano, Ximena; Porter, Louise M.; Bates, Lucy F.; Djamgoz, Mustafa B. A.

    2014-01-01

    The main aim of this investigation was to determine whether a functional relationship existed between epidermal growth factor (EGF) and voltage-gated sodium channel (VGSC) upregulation, both associated with strongly metastatic prostate cancer cells. Incubation with EGF for 24 h more than doubled VGSC current density. Similar treatment with EGF significantly and dose-dependently enhanced the cells’ migration through Transwell filters. Both the patch clamp recordings and the migration assay suggested that endogenous EGF played a similar role. Importantly, co-application of EGF and tetrodotoxin, a highly selective VGSC blocker, abolished 65% of the potentiating effect of EGF. It is suggested that a significant portion of the EGF-induced enhancement of migration occurred via VGSC activity. PMID:17960590

  11. Fatores de risco para câncer de mama em mulheres indígenas Teréna de área rural, Estado do Mato Grosso do Sul, Brasil Risk factors for breast cancer among rural Teréna Indian women in the State of Mato Grosso do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Marilana Geimba de Lima

    2001-12-01

    Full Text Available Com o objetivo de se avaliar a distribuição de fatores de risco em mulheres indígenas Teréna no Estado do Mato Grosso do Sul, duas amostras destas foram entrevistadas, respectivamente em 1995 (330 mulheres voluntárias de dez aldeias teréna de área rural e em 1997 (quarenta mulheres da Aldeia de Limão Verde. Os padrões de vida reprodutiva, dieta, antecedentes patológicos pessoais e familiares foram levantados, bem como a determinação do índice de massa corporal (IMC. Na maior amostra, observou-se que a idade média à menarca foi de 12,3 anos (30% das mulheres referindo-a aos 13 anos ou mais, 86% das mulheres com antecedentes de uma ou mais gestações (42% com cinco ou mais, 71% com antecedentes de três ou mais gestações, idade média à primeira gestação de 18,9 anos (3.8% com 28 anos ou mais, aleitamento materno com duração média de 84 meses, e 70% das mulheres menopausadas antes dos cinqüenta anos de idade. O padrão referido de dieta na menor amostra revela elevado consumo de frutas, legumes, raízes e macarrão, com ingestão escassa de carne vermelha e frango, observando-se que 50% (IC 95%: 34.1-65.9 das mulheres apresentaram sobrepeso (IMC 25-29 e 27% (IC 95%: 15.1-44.1 obesidade (IMC > 29.In order to evaluate the distribution of selected risk factors for breast cancer among Teréna Indian women in the State of Mato Grosso do Sul, Brazil, two samples were interviewed, respectively, in 1995 (330 women from ten Indian villages and 1997 (40 women from the Limão Verde village. Reproductive history, diet characteristics, and family and personal medical history were investigated and body mass index was measured. In the larger sample, mean age at menarche was 12.3 years (30% at 13 years old or later, 86% of women reported one or more pregnancies (42% reporting 5 or more, 71% reported three or more pregnancies, mean age at first pregnancy was 18.9 years (3.8% after 28 years, mean duration of breastfeeding was 84 months, and

  12. Probióticos e prebióticos na atenção primária ao câncer de cólon Probiotics and prebiotics in primary care for colon cancer

    Directory of Open Access Journals (Sweden)

    Fabiana Gouveia Denipote

    2010-03-01

    Full Text Available CONTEXTO: As neoplasias de cólon são a terceira forma mais comum de câncer atualmente. Seus tratamentos ainda estão associados a elevado risco de complicações, ressaltando, assim, a necessidade de elaborar novas estratégias de tratamento. A ingestão de probióticos, prebióticos ou a combinação de ambos (simbióticos, representa nova opção terapêutica. Diante da importância do equilíbrio quantitativo e qualitativo da microbiota intestinal para saúde humana e com objetivo de melhor elucidar o papel dos probióticos e prebióticos, o tema citado procura abordar a importância destes como coadjuvantes na prevenção e tratamento de câncer de cólon. METODOLOGIA: Foi realizada pesquisa em bancos de dados científicos (Medline, Lilacs, PubMed, Ovid, Scielo através de levantamento de artigos científicos, além da busca direta aos periódicos, priorizando-se os mesmos do período de 2003 a 2008. Foram, também, coletadas informações através de sites da internet, como forma de melhor compreender a epidemiologia, conceitos e tratamentos dessa patologia. RESULTADOS: Estudos apontam relação inversa entre o consumo de probióticos e prebióticos e o diagnóstico de câncer de cólon, sendo que alguns dos possíveis mecanismos englobam: aumento da resposta imune, redução da resposta inflamatória, inibição de formação de células tumorais e da conversão de substâncias pré-carcinogênicas em carcinogênicas. CONCLUSÃO: Através da realização desta revisão literária foi possível obter respostas positivas quanto ao uso de probióticos e prebióticos na carcinogênese, colocando seu uso como recomendado de forma adequada.CONTEXT: Colon neoplasias are presently the third most common cancer type. Its treatment is still associated with high risk of complications, thus emphasizing the need to design new treatment strategies. The ingestion of probiotics and prebiotics, or the combination of both (symbiotics, represents a new

  13. Prognostic impact of incomplete surgical clearance of radioiodine sensitive local lymph node metastases diagnosed by post-operative {sup 124}I-NaI-PET/CT in patients with papillary thyroid cancer

    Energy Technology Data Exchange (ETDEWEB)

    Sabet, Amir; Binse, Ina; Grafe, Hong; Goerges, Rainer; Poeppel, Thorsten D.; Bockisch, Andreas; Rosenbaum-Krumme, Sandra J. [University Duisburg-Essen, Department of Nuclear Medicine, Essen (Germany); Ezziddin, Samer [Saarland University, Department of Nuclear Medicine, Homburg (Germany)

    2016-10-15

    Nodal involvement is an independent risk factor of recurrence in papillary thyroid cancer (PTC). Neither the international guidelines nor the recently introduced ongoing risk adaptation concept consider the extent of initial surgical clearance of radioiodine sensitive lymph node metastases in their stratification systems. We investigated the prognostic relevance of incomplete initial surgical clearance in patients with purely lymphogeneous metastatic PTC (pN1 M0) despite successful radioiodine therapy. Accurate assessment of pre-ablative nodal status was attempted using PET/CT studies with both {sup 124}I-NaI and {sup 18}F-FDG along with high-resolution cervical ultrasound. Sixty-five patients with histologically diagnosed lymph node metastases (pN1 M0) were retrospectively analyzed. Patients with iodine-negative lymph node metastases diagnosed by {sup 18}F-FDG PET/CT or distant metastases were excluded from the analysis. The association of disease recurrence with the pre-ablative nodal status, as well as other baseline characteristics, were examined applying nonparametric tests for independent samples and multiple regression analysis. Patients with persistent lymph node metastases in {sup 124}I-NaI PET/CT were further divided according to the additional presence or absence of FDG-uptake in {sup 18}F-FDG PET/CT. Survival analyses were performed using Kaplan-Meier curves and the Cox proportional hazards model for uni- and multivariate analyses to assess the influence of prognostic factors on progression free survival (PFS). Incomplete metastatic lymph node resection captured by {sup 124}I-NaI PET/CT (n = 33) was an independent risk factor for recurrence (61 % vs 25 %, p = 0.006) and shorter PFS (46 months vs not reached, HR 4.0 [95 %-CI, 1.7-9.2], p = 0.001). Ultrasound could detect lymph node metastases only in 19/33 patients (58 %). Among patients with positive nodal status, FDG-avidity of metastatic iodine positive lymph nodes worsened the outcome (16 vs 69

  14. The NA57 experiment

    CERN Multimedia

    Laurent Guiraud

    1997-01-01

    NA57 is one of the seven experiments (NA44, NA45, NA49, NA50, NA52, WA97/NA57 and WA98) involved in CERN's Heavy Ion programme, which provided evidence for the existence of a new state of matter, the quark-gluon plasma. In this state, quarks, instead of being bound up into more complex particles such as protons and neutrons, are liberated and roam freely. Theory predicts that this state must have existed at about 10 microseconds after the Big Bang, before the formation of matter as we know it today.

  15. "... e Deus criou a mulher": reconstruindo o corpo feminino na experiência do câncer de mama "... and God Created Woman": reconstructing the female body in the breast cancer experience

    Directory of Open Access Journals (Sweden)

    Waleska de Araújo Aureliano

    2009-04-01

    Full Text Available As mulheres atingidas pelo câncer de mama passam, a partir da experiência da enfermidade, a travar novas relações com o corpo modificado pela cirurgia de mama (mastectomia, que provoca profundas alterações corporais. Considerando as representações simbólicas e sociais que envolvem o corpo da mulher e a associação das mamas à feminilidade, à sexualidade e à maternidade, pretendo discutir neste artigo como a ideia do corpo feminino e dos papéis sociais associados a ele foi histórica, social e culturalmente construída em nossa sociedade, como essa representação é percebida e reelaborada pela mulher mastectomizada e quais os discursos e visões (muitas vezes ambíguos que passam a ser utilizados para a compreensão desse corpo após a experiência da doença. A pesquisa foi realizada com mulheres de dois grupos de ajuda mútua na cidade de Campina Grande, PB.After knowing about their illness, women with breast cancer start to deal with new forms of perception of their own bodies, specially when modified by mastectomy (breast surgery. This medical procedure has profound impact in body formation. Considering the symbolic and social representations that involve the woman's body and the association of breasts with femininity, sexuality and maternity, I intend to demonstrate in this article how the idea of a female body and the roles associated with it were historical, social and culturally constructed in our society. I also investigate how the symbolic representations of that female body are perceived and re-elaborated by the woman with breast cancer through (sometimes ambiguous narratives and perceptions, which are, later, used to understand their body after experiencing the illness. The research was accomplished with women of two groups of mutual aid in the city of Campina Grande, PB.

  16. Sentinel lymph node biopsy in patients with locally advanced breast cancer after neoadjuvant chemotherapy Biopsia do linfonodo sentinela em câncer na mama localmente avançado pós-quimioterapia neoadjuvante

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    Paulo Henrique Walter Aguiar

    2012-12-01

    Full Text Available PURPOSE: To check the rate of sentinel lymph node (SLN identification in patients with locally advanced breast cancer who underwent neoadjuvant chemotherapy comparing intraoperative contact cytology (imprint and embedded in paraffin and validation of methods. METHODS: A cross-sectional validation of diagnostic test involving 34 patients from the outpatient clinic of the Maternity School Assis Chateaubriand. The patients had locally advanced breast cancer and were treated with neoadjuvant chemotherapy. Those with clinically negative axilla underwent SLN biopsy, studied by imprint and histopathology in paraffin. All patients underwent axillary dissection and its histopathological study. RESULTS: The SLN identification rate was 85.3% (29/34. The sensitivity of imprint associated with paraffin on detection of metastasis compared to histopathology of the axillary content was 84.62% and specificity of 100% with false-negative rate of 12.01% and an accuracy of 92.77%. CONCLUSION: The search for metastases in the SLN by imprint and histopathological analysis in paraffin compared to the gold standard (axillary dissection had a low sensitivity with high rate of false negatives in our sample.OBJETIVO: Verificar a taxa de identificação do linfonodo sentinela (LS em pacientes portadoras de câncer na mama localmente avançado e que foram submetidos à quimioterapia neoadjuvante comparando a citologia de contato intraoperatória (imprint e a inclusão em parafina e validação dos procedimentos. MÉTODOS: Estudo transversal de validação de teste diagnóstico envolvendo 34 pacientes oriundas do Ambulatório da Maternidade-Escola Assis Chateaubriand. As pacientes eram portadoras de câncer na mama localmente avançado e foram tratadas com quimioterapia neoadjuvante. Àquelas com axila clinicamente negativa foram submetidas à biopsia do LS, esse estudado por impint e histopatologia em parafina. Todas as pacientes foram submetidas a esvaziamento axilar e seu

  17. Prognostic significance of the p185 protein in colorectal cancer Significado pronóstico de la proteína p185 en cáncer colorrectal

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    M. T. Sanz-Casla

    2004-02-01

    Full Text Available The amplification and/or overexpression of the c-erbB-2/neu oncogene may play a role in tumor development and progression. The aim of this prospective study was to evaluate the prognostic value of p185 protein in colorectal cancer using immunohistochemical techniques. We analyzed 106 colorectal tumor tissue specimens from patients who had been operated on by the same surgeon and subjected to a median follow-up of 3 years. Thirty-three per cent of patients showed p185 overexpression related to an advanced stage of the disease. In patients with adenocarcinoma tumors of the colon without distant metastases, p185 detection was found to be of clinical prognostic relevance (p = 0.06.La amplificación y/o sobre-expresión del oncogén c-erbB2/neu puede contribuir al desarrollo y progresión tumoral. El objetivo de este trabajo es el estudio del valor pronóstico de la proteína p185 mediante técnicas de inmunohistoquímica en el carcinoma colorrectal. Se trata de un estudio de cohortes prospectivo en 106 muestras de tejido tumoral colorrectal de pacientes intervenidos quirúrgicamente por un mismo cirujano y con una mediana de tiempo de seguimiento de 3 años. El 33% de los pacientes presenta sobre-expresión de p185, que se relaciona con estadios avanzados de la enfermedad. En los pacientes con tumores adenocarcinoma localizados en colon y sin metástasis a distancia, la determinación de p185 muestra valor pronóstico clínicamente relevante (p=0,06.

  18. Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions.

    Science.gov (United States)

    Gurav, Ashish; Sivaprakasam, Sathish; Bhutia, Yangzom D; Boettger, Thomas; Singh, Nagendra; Ganapathy, Vadivel

    2015-07-15

    Mammalian colon harbours trillions of bacteria under physiological conditions; this symbiosis is made possible because of a tolerized response from the mucosal immune system. The mechanisms underlying this tolerogenic phenomenon remain poorly understood. In the present study we show that Slc5a8 (solute carrier gene family 5a, member 8), a Na(+)-coupled high-affinity transporter in colon for the bacterial fermentation product butyrate, plays a critical role in this process. Among various immune cells in colon, dendritic cells (DCs) are unique not only in their accessibility to luminal contents but also in their ability to induce tolerogenic phenotype in T-cells. We found that DCs exposed to butyrate express the immunosuppressive enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and aldehyde dehydrogenase 1A2 (Aldh1A2), promote conversion of naive T-cells into immunosuppressive forkhead box P3(+) (FoxP3(+)) Tregs (regulatory T-cells) and suppress conversion of naive T-cells into pro-inflammatory interferon (IFN)-γ-producing cells. Slc5a8-null DCs do not induce IDO1 and Aldh1A2 and do not generate Tregs or suppress IFN-γ-producing T-cells in response to butyrate. We also provide in vivo evidence for an obligatory role for Slc5a8 in suppression of IFN-γ-producing T-cells. Furthermore, Slc5a8 protects against colitis and colon cancer under conditions of low-fibre intake but not when dietary fibre intake is optimal. This agrees with the high-affinity nature of the transporter to mediate butyrate entry into cells. We conclude that Slc5a8 is an obligatory link between dietary fibre and mucosal immune system via the bacterial metabolite butyrate and that this transporter is a conditional tumour suppressor in colon linked to dietary fibre content.

  19. Qualidade e desempenho das colpocitologias na prevenção de câncer de colo uterino Quality and performance of pap smears in the cervical cancer screening program in a city of southern Brazil

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    Nelson Shozo Uchimura

    2009-01-01

    Full Text Available OBJETIVO: Estimar a prevalência e analisar a qualidade e o desempenho das colpocitologias realizadas no Programa de Prevenção de Câncer de Colo Uterino no município de Maringá-PR. MÉTODOS: Estudo retrospectivo dos dados do SIS-Colo do Ministério da Saúde. Foram analisadas as variáveis idade, resultado de colpocitologia e procedência. As idades foram categorizadas em faixas etárias, a procedência distribuída em cinco regionais de saúde do município de Maringá; a colpocitologia foi categorizada conforme o Sistema Bethesda. Calculou-se a cobertura de colpocitologia dividindo-se o número de exames na população de 25 a 59 anos pelo número de mulheres nesta mesma faixa etária. RESULTADOS: As 17.664 colpocitologias coletadas, no ano de 2005, pela rede pública se distribuíram entre as mulheres com idade mínima de 12 e máxima de 82 anos, sendo 12.961 (73,4% exames na faixa entre 25 e 59 anos, considerada de maior risco para o câncer. Foram negativos para neoplasia 17.458 (98,84% exames e as alterações celulares (ASCUS/AGUS, LIEBG, LIEAG e câncer invasor totalizaram 206 (1,16%. Encontrou-se prevalência de ASCUS de 0,85% (151, de atipias celulares 1,14% (203/17.664 e a relação ASCUS/atipias celulares 2,75% (151/55. CONCLUSÃO: A prevalência das alterações colpocitológicas e da ASCUS abaixo dos índices esperados, a relação ASCUS/atipias celulares em níveis elevados, a cobertura populacional insuficiente de colpocitologia compromete o desempenho da prevenção de câncer de colo uterino. A população de baixa condição sócio-econômica requer uma atenção especial e a população mais privilegiada deve ser orientada quanto a periodicidade do exame e faixa etária de maior risco.OBJECTIVE: To estimate prevalence and analyze quality and performance of colpocytology carried out under the Cervical Cancer Screening Program in Maringá, Paraná, Brazil. METHODS: A retrospective study of the SIS-Colo database of the

  20. Angelite: Paziteli na vhoda

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    Gerov Georgi

    2009-01-01

    Full Text Available (bugarski Statijata prosledjava ikonografskata evoljucija na izobraženijata na arhangelite Mihail i Gavriil, pomesteni pri vhoda na pravoslavnija hram. Povraten moment v neja e 13 vek. Togava arhangel Mihail započva da se izobrazjava kato voin. S tova apotropejnite mu funkcii namirat adekvaten vizualen izraz. K'm kraja na stoletieto arhangel Gavriil započva da se izobrazjava kato pisar - ikonografija, kojato šče b'de dorazvita i utv'rdena prez 14 vek. Prez postvizantijskata epoha v obraza na Mihail se pojavjavat elementi, koito akcentirat v'rhu roljata mu na psihopomp.

  1. Fatores prognósticos na ressecção de metástases hepáticas de câncer colorretal Prognostic factors following liver resection for hepatic metastases from colorectal cancer

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    Aljamir Duarte Chedid

    2003-09-01

    Full Text Available OBJETIVO: Determinar o impacto de fatores prognósticos na sobrevida de pacientes com metástases hepáticas ressecadas e originadas de câncer colorretal. CASUÍSTICA E MÉTODOS: Foram analisados os prontuários de 28 pacientes submetidos a ressecção hepática de metástases de câncer colorretal de abril de 1992 a setembro de 2001. Foram realizadas 38 ressecções (8 pacientes com mais de uma ressecção no mesmo tempo cirúrgico e 2 pacientes submetidos a re-ressecções. Todos haviam sido submetidos previamente a ressecção do tumor primário. Utilizou-se protocolo de rastreamento de metástases hepáticas que incluiu revisões clínicas trimestrais, ecografia abdominal e dosagem de CEA até se completarem 5 anos de seguimento e após, semestralmente. Os fatores prognósticos estudados foram: estágio do tumor primário, tamanho das metástases > 5cm, intervalo entre ressecção do tumor primário e surgimento da metástase 100 ng/mL, margens cirúrgicas AIM: To determine the impact of prognostic factors on survival of patients with metastases from colorectal cancer that underwent liver resection. METHODS: The records of 28 patients that underwent liver resection for metastases from colorectal cancer between April 1992 and September 2001 were retrospectively analyzed. Thirty-eight resections were performed (more than one resection in eight patients and two patients underwent re-resections. The primary tumor was resected in all the patients. A screening protocol for liver metastases including clinical examinations every three months, ultrassonography and CEA level until 5 years of follow-up and after every 6 months, was applied. The prognostic factors analyzed regarding the impact on survival were: Dukes C stage of primary tumor, size of metastasis >5 cm, a disease-free interval from primary tumor to metastasis 100 ng/mL, resection margins < 1 cm and extrahepatic disease. The Kaplan-Meier curves, log rank and Cox regression were used for

  2. Implications of Helicobacter pylori infection for stomach cancer prevention Implicações da infecção por Helicobacter pylori na prevenção do câncer de estômago

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    Karen J. Goodman

    1997-01-01

    Full Text Available Accumulating evidence has implicated Helicobacter pylori, an established cause of chronic gastritis and peptic ulcer, in the etiology of gastric cancer. Control of this infection would reduce the occurrence of chronic gastritis and peptic ulcer and might substantially lower the risk of stomach cancer as well. The public health impact of this infectious agent warrants efforts to identify preventive measures. This paper reviews the evidence linking H. pylori infection to gastric cancer and evaluates the potential for control in high-risk populations. Current obstacles to H. pylori control are discussed, including the link to poor socioeconomic conditions, difficulty in identifying incident cases, lack of natural immunity to reinfection, limited effectiveness of antibiotic therapy in high-prevalence populations, and incomplete knowledge regarding the reservoir of infection, mode of transmission, host susceptibility factors, and the potential for developing an effective vaccine. Worthwhile avenues of research include studies designed to identify modifiable risk factors for acquisition of the infection, modifiable host factors that may increase resistance to chronic infection, more effective antibiotic therapies, and effective vaccines.Um acúmulo de evidências aponta para Helicobacter pylori, uma causa comprovada de gastrite e úlcera péptica, na etiologia do câncer gástrico. O controle dessa infecção poderia reduzir a ocorrência de gastrite crônica e úlcera péptica, além de diminuir o risco de câncer de estômago. O impacto desse agente infeccioso em nível de saúde pública justifica os esforços no sentido de identificar medidas preventivas. Este artigo revê as evidências ligando o H. pylori ao câncer de estômago e avalia o potencial para controle em populações de alto risco. A autora discute os obstáculos atuais ao controle do H. pylori, inclusive sua associação com condições suir o risco de câncer de estômago. O

  3. Efeito da clorexidina na mucosite induzida por radioterapia em câncer de cabeça e pescoço Effects of chlorhexidine mouthwash on radiation induced mucosistis in head and neck cancer

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    Rogério Labbate

    2003-06-01

    Full Text Available A radioterapia em pacientes com neoplasias de Cabeça e Pescoço causa alterações na mucosa oral comprometendo a execução terapêutica e o resultado final. OBJETIVO: Avaliar o efeito protetor do gluconato de clorexidina, sobre a mucosa oral, durante o tratamento actínico fracionado e o seu reflexo na qualidade de vida referida pelos pacientes. FORMA DE ESTUDO: Clínico prospectivo. MATERIAL E MÉTODO: Foram selecionados 21 portadores de câncer de Cabeça e Pescoço alocados em dois grupos: grupo Placebo (n=11, 9H e 2M, idade média 58 anos água destilada - dois bochechos diários e grupo Medicação (n=10, 7H e 2M, idade média 52 anos gluconato de clorexidina a 0,12% - dois bochechos diários. Os pacientes foram avaliados semanalmente com exame local para detecção das alterações de mucosa (classificação de acordo com a WHO e Grupo de Terapia por Radiação em Oncologia - graus 0 a IV e preenchimento de questionário de qualidade de vida ressaltando os aspectos de dor, apetite, paladar e hábitos alimentares. A análise estatística realizada pelo teste exato de Fisher. RESULTADOS: A graduação da mucosite foi mais intensa no grupo Placebo em 6 das 10 semanas de avaliação. A freqüência e intensidade das dores foram piores no grupo Placebo na 4ª semana de radioterapia e a modificação de paladar foi mais intensa nos indivíduos que não usavam o medicamento apenas na 7ª semana. Não foram encontradas diferenças nos outros parâmetros de qualidade de vida. CONCLUSÃO: Podemos concluir que o gluconato de clorexidina não eliminou as lesões de mucosa mas diminuiu, significativamente, os seus efeitos deletérios e intensidade sem apresentar um reflexo persistente na qualidade de vida dos pacientes.The radiotherapy in patients with neoplasias of Head and Neck causes alterations in the oral mucous membrane interfering with the therapeutic execution and the final result. AIM: To evaluate the protective effect of the chlorhexidin

  4. Proposta de metodização da linfadenectomia mediastinal na cirurgia do câncer de pulmão Methodization for mediastinal limphadenectomy in lung cancer resection

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    Vitório Moscon Puntel

    2003-06-01

    Full Text Available OBJETIVO: Estabelecer uma padronização anatômica da linfadenectomia mediastinal como complementação à cirurgia do câncer de pulmão. MÉTODO: 1 - Foram enviados para vinte e dois cirurgiões torácicos brasileiros, questionários sobre linfadenectomia mediastinal. 2 - Realizou-se extensa revisão bibliográfica sobre a anatomia dos linfáticos do mediastino e descrições das técnicas de dissecação linfática mediastinal. 3 - Procedeu-se à dissecação do mediastino em cinco cadáveres não formolizados. 4 - Estabelecido os limites anatômicos de cada loja linfonodal foram realizadas vinte e sete fotografias de cada uma das referidas lojas antes e após a dissecação. RESULTADOS: Não houve consenso entre os cirurgiões que responderam ao questionário quanto a realização ou não e quanto à forma de realizar a linfadenectomia do mediastino na cirurgia do câncer pulmonar, significando que a técnica merece uma metodização. Movidos por esta necessidade e baseados na análise dos itens 2, 3 e 4 acima relacionados, propusemos uma metodização da linfadenectomia mediastinal de forma objetiva, definindo claramente os limites anatômicos de cada loja ganglionar no mediastino direito e esquerdo e especificando aquelas a serem abordadas de acordo com o sítio primário da lesão no lobo pulmonar. CONCLUSÃO: É possível definir claramente uma metodização técnica de fácil execução da linfadenectomia mediastinal, baseado em critérios anatômicos.BACKGROUND: To establish an easily performing methodization for mediastinal limphadenectomy technique as a complement to lung cancer resection. METHODS: Twenty-two standard questionnaire were sent to several thoracic surgeons from several parts of Brazil. We evaluated the literature about the techniques described for mediastinal limphadenectomy by the following authors: Naruke, Martini, Izibicki and Watanabe. A literature review on the anatomy of mediastinal and pulmonary lymphatics has

  5. Increasing Breast Cancer Surveillance among African American Breast Cancer Survivors

    Science.gov (United States)

    2005-07-01

    Madam , The project entitled INCREASING BREAST CANCER SURVEILLANCE AMONG AFRICAN AMERICAN BREAST CANCER SURVIVORS includes activities involving human...B b- d § fr. Thomisonwill Work e .y .With’Dra) Vdldf naTir, W and y Bo • rganif Janidorf on data a"_`l- ssi reatihfiutfor pres~entatidns and publi

  6. A serendipidade na medicina e na anestesiologia

    OpenAIRE

    Vale,Nilton Bezerra do; Delfino,José; Vale,Lúcio Flávio Bezerra do

    2005-01-01

    JUSTIFICATIVA E OBJETIVOS: Neste trabalho foram examinados mais de uma centena dos mais felizes acoplamentos de uma mente brilhante com a sorte benfazeja (serendipidade), através da releitura das mais relevantes histórias sobre invenções e descobertas relacionadas à ciência (n = 46), à Medicina (n = 46) e à Anestesiologia (n = 16). CONTEÚDO: Conceito de serendipidade; exemplos célebres de serendipidade em Ciência e Tecnologia; serendipidade na pesquisa e prática médicas; serendipidade na Anes...

  7. Cancer incidence in the Western Amazon: population-based estimates in Rio Branco, Acre State, Brazil, 2007-2009 Incidência de câncer na Amazônia ocidental: estimativa de base populacional em Rio Branco, Acre, Brasil, 2007-2009

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    Juliano de Pádua Nakashima

    2012-11-01

    Full Text Available Cancer incidence rates vary widely in Brazil. The literature on the subject for the western Amazon region is scarce. This study aimed to determine cancer incidence in the population of Rio Branco, Acre State. A total of 718 new cases were recorded during the study period. Among men, the five leading cancer sites were prostate (ASR 75.1, stomach (ASR 23.0, lung (ASR 19.1, colon and rectum (ASR 9.5, and leukemia (ASR 6.9. Among women, they were breast (ASR 41.5, cervix (ASR 41.3, lung (ASR 11.8, colon and rectum (ASR 11.0, and stomach (ASR 7.7. These indicators reveal that Rio Branco has a cancer incidence pattern that overlaps with epidemiological cancer patterns observed in developed and developing regions. The results of the study point to the importance of implementing a population-based cancer registry - currently nonexistent in Rio Branco - as a factor to promote analysis of incident cases of the disease and monitoring of its evolution.No Brasil, as taxas de incidência de câncer variam amplamente. A literatura sobre o tema na região da Amazônia Ocidental é escassa. Este trabalho teve como objetivo determinar a incidência atual de câncer na população de Rio Branco, Acre. Registrou-se um total de 718 casos novos no período de estudo. As localizações tumorais de maior incidência em homens foram: próstata (75,1/100.000, estômago (23,0/100.000, pulmão (19.1/100.000, cólon-reto (9,5/100.000 e leucemias (6,9/100.000 e no sexo feminino: mama (41,5/100.000, colo uterino (41,3/100.000, pulmão (11,8/100.000, cólon-reto (11,0/100.000 e estômago (7,7/100.000. Esses indicadores revelam que Rio Branco apresenta um padrão de incidência por câncer que superpõe os padrões encontrados nas regiões desenvolvidas e em desenvolvimento. Os resultados do trabalho apontam para a importância da implementação de um registro de câncer de base populacional - atualmente inexistente em Rio Branco - como fator promotor da análise de casos

  8. Colon cancer

    Science.gov (United States)

    Colorectal cancer; Cancer - colon; Rectal cancer; Cancer - rectum; Adenocarcinoma - colon; Colon - adenocarcinoma ... In the United States, colorectal cancer is one of the leading causes of deaths due to cancer. Early diagnosis can often lead to a complete cure. Almost ...

  9. Cats, Cancer and Comparative Oncology

    OpenAIRE

    Cannon, Claire M.

    2015-01-01

    Naturally occurring tumors in dogs are well-established models for several human cancers. Domestic cats share many of the benefits of dogs as a model (spontaneous cancers developing in an immunocompetent animal sharing the same environment as humans, shorter lifespan allowing more rapid trial completion and data collection, lack of standard of care for many cancers allowing evaluation of therapies in treatment-naïve populations), but have not been utilized to the same degree in the One Medici...

  10. Mastectomy versus conservative surgical treatment: the impact on the quality of life of women with breast cancer Mastectomia versus tratamento cirúrgico conservador: impacto na qualidade de vida de mulheres com câncer mamário

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    Daniela Francescato Veiga

    2010-03-01

    Full Text Available OBJECTIVES: to compare the impact of mastectomy and conservative surgery on the quality of life of patients with breast cancer. METHODS: an assessment was made of the quality of life of patients undergoing mastectomy or segmentary mastectomy, at the Pouso Alegre Clinical Hospital, in the Brazilian State of Minas Gerais, using SF-36. The patients were grouped by age (50 years and years of schooling (8 years. The Mann-Whitney test was used to compare the groups with regard to the age and schooling domains of SF-36. RESULTS: a significant difference between the two groups was found in the domains of "physical functioning" (p=0.04 and "pain" (p=0.01: with the patients undergoing a mastectomy registering the worst scores. Young patients who had undergone a mastectomy displayed the worst quality of life in terms of "physical functioning" (p=0.03, "pain" (p=0.01 and "social functioning" (p=0.01; those undergoing conservative surgery aged over 50 years scored worst on "role emotional" (p=0.05. Patients undergoing a mastectomy with lower levels of schooling scored lower in "physical functioning" (p=0.01, "role physical" (p=0.05 and "pain" (p=0.05. Among those who had attended school for more than eight years, those having undergone a mastectomy scored less in the "pain" domain (p=0.04. CONCLUSIONS: patients who had undergone a mastectomy had worse results in the physical component of the evaluation of quality of life and this negative impact was more strongly felt among younger patients and those with lower levels of schooling.OBJETIVOS: comparar o impacto da mastectomia e da cirurgia conservadora na qualidade de vida de pacientes com câncer mamário. MÉTODOS: avaliou-se qualidade de vida de pacientes submetidas à mastectomia ou à mastectomia segmentar, no Hospital das Clínicas de Pouso Alegre, Minas Gerais, Brasil, utilizando-se o SF-36. As pacientes foram estratificadas quanto à idade (50 anos e escolaridade (8 anos. Aplicou-se o teste de Mann

  11. A comunicação na abordagem preventiva do câncer do colo do útero: importância das influências histórico-culturais e da sexualidade feminina na adesão às campanhas Communication in the prevention of cervix uteri cancer: the importance of historical cultural influences and of feminine sexuality in the adhesion to campaigns

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    Luciana Maria Britto da Cruz

    2008-06-01

    Full Text Available Considerando que o câncer cérvico-uterino ainda se apresenta como problema de saúde pública no Brasil e que os programas governamentais de prevenção existentes para esse câncer não alcançaram a meta estimada, visto que a cobertura e o número de atendimentos nas campanhas não atingiram um quarto do estimado na primeira campanha; e, na segunda, o alcance foi inferior à primeira, este artigo se propôs a levantar questões referentes a não adesão de muitas mulheres às campanhas. Para isso, foram ressaltadas a relevância epidemiológica para a abordagem do tema; a importância do corpo para a mulher; e as influências histórico-culturais no comportamento preventivo das mulheres. Dessa forma, foi realizado um estudo teórico descritivo, usando como fonte principal de informações dados do Ministério da Saúde e do Instituto Nacional do Câncer (INCA e como fonte de apoio livros, artigos científicos, periódicos e dissertações que abordam a temática proposta. A fim de discutir possibilidades estratégicas que possam ser eficazes para uma maior adesão feminina às campanhas preventivas, foi considerada a importância da forma de abordagem dos profissionais de saúde, salientando para que atuem correspondendo aos valores culturais apresentados pelas mulheres. Além disso, ressaltou-se a linguagem utilizada nas campanhas de prevenção do câncer do colo do útero, atentando para o fato de que conceitos transmitidos podem endossar valores culturais de abordagem do feminino que dificultam a identificação e a adesão de muitas mulheres.Cervix uteri cancer is still a public health problem in Brazil, but the governmental prevention programs that exist for this type of cancer have not reached the estimated index of covering. The number of people assisted in the campaigns has not reached one quarter of what was estimated in the first campaign and in the second one the number was even inferior. In light of this situation, this article

  12. Balanço entre ácidos graxos ômega-3 e 6 na resposta inflamatória em pacientes com câncer e caquexia Omega-3 and 6 fatty acids balance in inflammatory response in patients with cancer and cachexia

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    Adriana Garófolo

    2006-10-01

    Full Text Available O emagrecimento, associado à perda de massa magra, é um fenômeno observado com freqüência em pacientes com câncer. Tal condição predispõe o paciente ao maior risco de infecções, pior resposta aos tratamentos implantados e, como conseqüência, desfavorece o prognóstico de cura. Além disso, a desnutrição também está associada à pior qualidade de vida. Dessa forma, algumas terapias têm sido propostas na tentativa de reverter o catabolismo, por meio da atenuação da resposta inflamatória, observado em grande porcentagem de pacientes com câncer e caquexia. Entre elas, a suplementação com ácidos graxos da família ômega-3 pode representar uma estratégia na redução da formação de citocinas pró-inflamatórias, favorecendo a tolerância metabólica dos substratos energéticos e atenuando o catabolismo protéico, com o intuito de melhorar o prognóstico de cura de pacientes com câncer. Entretanto, os estudos mostram alguns resultados conflitantes da suplementação com ômega-3 na resposta imunológica. Por outro lado, em pacientes com câncer, os ensaios clínicos mostraram atenuar a resposta inflamatória e melhorar o estado nutricional. O objetivo deste artigo é realizar uma revisão criteriosa do assunto.Emaciation and loss of lean body mass is a frequent phenomenon observed in cancer patients. This condition leads to infection risk and a poor response to treatment, thus reducing the chances of cure. Furthermore, malnutrition is also associated with a poor quality of life. Therefore, therapies have been proposed in attempt to revert the catabolism observed in most of these patients by attenuating the inflammatory response. Among them, omega-3 fatty acid supplementation may be a strategy to reduce the production of pro-inflammatory cytokines and improve metabolic substrate tolerance, decreasing protein catabolism in order to ameliorate the prognosis of cure in cancer patients. However, studies demonstrate some

  13. Utilizacao de medicamentos pela populacao quilombola: inquerito no Sudoeste da Bahia

    Directory of Open Access Journals (Sweden)

    Danielle Souto de Medeiros

    2013-10-01

    Full Text Available OBJETIVO Analisar o uso de medicamentos pela população quilombola. MÉTODOS Estudo transversal de base populacional com 797 quilombolas adultos de Vitória da Conquista, BA, em 2011. Utilizou-se análise de variância para comparar as médias de medicamentos por indivíduo segundo variáveis demográficas, socioeconômicas e de comportamentos relacionados à saúde. Foram estimadas as prevalências, razões de prevalência e os respectivos intervalos de confiança de 95%. Análise múltipla foi conduzida por meio de regressão de Poisson com variância robusta. RESULTADOS Os medicamentos mais consumidos pela população foram aqueles que atuam nos sistemas cardiovascular e nervoso. A prevalência de uso de medicamentos foi de 41,9%, significativamente maior nas mulheres (50,3% do que nos homens (31,9%. Após análise ajustada, o uso de fármacos foi associado a sexo feminino, idade de 60 anos e mais, nível econômico mais alto, pior avaliação da saúde, maior número de morbidades autorreferidas e de consultas médicas. CONCLUSÕES Mulheres e idosos deverão ser os grupos de preferência para o desenvolvimento de estratégias específicas que garantam o uso racional dos medicamentos. É necessária a promoção de prescrição racional no cotidiano dos serviços de saúde.

  14. At NA2

    CERN Multimedia

    1977-01-01

    One of the NA2 calorimeter sections is moved in. The NA2 calorimeter was divided in two halves, to the left and the right of the beam, each half consisting of sheets of passive high Z material interleaved with blades of plastic scintillators. The photo shows on the right, the upstream 'electron' module with eleven lead plates for a total radiation length of 20.

  15. (−)-Englerin A-evoked Cytotoxicity Is Mediated by Na+ Influx and Counteracted by Na+/K+-ATPase*

    Science.gov (United States)

    Ludlow, Melanie J.; Gaunt, Hannah J.; Rubaiy, Hussein N.; Musialowski, Katie E.; Blythe, Nicola M.; Vasudev, Naveen S.; Muraki, Katsuhiko; Beech, David J.

    2017-01-01

    (−)-Englerin A ((−)-EA) has a rapid and potent cytotoxic effect on several types of cancer cell that is mediated by plasma membrane ion channels containing transient receptor potential canonical 4 (TRPC4) protein. Because these channels are Ca2+-permeable, it was initially thought that the cytotoxicity arose as a consequence of Ca2+ overload. Here we show that this is not the case and that the effect of (−)-EA is mediated by a heteromer of TRPC4 and TRPC1 proteins. Both TRPC4 and TRPC1 were required for (−)-EA cytotoxicity; however, although TRPC4 was necessary for the (−)-EA-evoked Ca2+ elevation, TRPC1 was not. TRPC1 either had no role or was a negative regulator of Ca2+ entry. By contrast, both TRPC4 and TRPC1 were necessary for monovalent cation entry evoked by (−)-EA, and (−)-EA-evoked cell death was dependent upon entry of the monovalent cation Na+. We therefore hypothesized that Na+/K+-ATPase might act protectively by counteracting the Na+ load resulting from sustained Na+ entry. Indeed, inhibition of Na+/K+-ATPase by ouabain potently and strongly increased (−)-EA-evoked cytotoxicity. The data suggest that (−)-EA achieves cancer cell cytotoxicity by inducing sustained Na+ entry through heteromeric TRPC1/TRPC4 channels and that the cytotoxic effect of (−)-EA can be potentiated by Na+/K+-ATPase inhibition. PMID:27875305

  16. ETAŽNA LASTNINA S POUDARKOM NA ZVEtL

    OpenAIRE

    Cvetko, Tadej

    2014-01-01

    Etažna lastnina je lastnina posameznega dela zgradbe in solastnina na skupnih delih, ki služijo vsem ali nekaterim posameznim delom zgradbe. Etažna lastnino na območju Republike Slovenije je uvedel Zakon o lastnini na delih stavbe kot odgovor na potrebo po hitri nacionalizaciji stanovanj in odrazu doslednega uvajanja osnovne ideje takratnega socialističnega duha t.j. družbene lastnine. Slovenija kot mlada demokratična država je ob tranziciji iz socialističnega v demokratični sistem poskušala ...

  17. Prognosis of breast cancer during pregnancy: evidence for nursing care El pronóstico de cáncer de mama en el embarazo: evidencias para la atención de enfermería O prognóstico de câncer de mama na gravidez: evidências para o cuidado de enfermagem

    Directory of Open Access Journals (Sweden)

    Ana Fátima Carvalho Fernandes

    2011-12-01

    Full Text Available This integrative review analyzed evidence available in the literature concerning the prognosis of breast cancer during pregnancy. The following databases were used for selecting studies: PubMed, CINAHL and LILACS. A total of 240 primary studies were identified; 13 papers were included in the integrative review’s sample after reading the titles and abstracts and according to the established inclusion and exclusion criteria. There is evidence indicating that pregnancy does not worsen the evolution of breast cancer and a poor prognosis is related to late stage tumors. Among the gaps identified in the studied theme, the need for further studies addressing nursing care provided to pregnant women with breast cancer is highlighted in order to promote improved care in the context of health care.Esta revisión integradora de la literatura objetivó analizar las evidencias disponibles en la literatura sobre el pronóstico del cáncer de mama durante el embarazo. La selección de los estudios primarios fue realizada en las bases de datos PubMed, CINAHL y LILACS; se identificaron 240 estudios primarios. Después de la lectura de los títulos y resúmenes y establecimiento de los criterios de inclusión y exclusión, 13 artículos fueron incluidos en la muestra de la revisión integradora. En la síntesis del conocimiento producido hay evidencias que indican que el embarazo no empeora la evolución del cáncer de mama y el pronóstico malo está relacionado con la estadificación clínica tardía del tumor. Entre las lagunas en el tópico investigado hay que resaltar la necesidad de realizar estudios sobre la atención de enfermería prestada a mujeres embarazadas con cáncer de mama para mejoría del cuidado en el contexto de la atención a la salud.O presente estudo teve como objetivo analisar as evidências disponíveis na literatura sobre o prognóstico de câncer de mama na gravidez. O método de revisão adotado foi a revisão integrativa. Para a

  18. Results of treatment of laryngeal cancer based on 11 years material of the Babinski Regional Hospital in Wroclaw; Podsumowanie wynikow leczenia chorych na raka krtani w 11-letnim materiale Oddzialu Laryngologicznego Wojewodzkiego Szpitala Zespolonego im J. Babinskiego

    Energy Technology Data Exchange (ETDEWEB)

    Gul, E.; Rowinska, E.; Lewandowski, A.; Pres, K.; Delikat, D.; Turek, W. [Oddzial Laryngologiczny, Wojewodzki Szpital Zespolony im J. Babinskiego, Wroclaw (Poland)

    1994-12-31

    The treatment results of patients with laryngeal cancer have been presented on the ground of an 11-year material (1982-1992). In the analysis age, sex, occupation, place of living and tobacco smoking have been taken into consideration. Clinical condition has been evaluated regarding the stage of advancement and localization. the ways and results of treatment have been discussed. (author)

  19. Barreiras na realização da colpocitologia oncótica: um inquérito domiciliar na área de abrangência da Saúde da Família de Nova Iguaçu, Rio de Janeiro, Brasil Barriers to implementation of cervical cancer screening: a household survey in the coverage area of the Family Health Program in Nova Iguaçu, Rio de Janeiro State, Brazil

    Directory of Open Access Journals (Sweden)

    Ricardo de Mattos Russo Rafael

    2010-05-01

    Full Text Available O objetivo deste estudo foi analisar as barreiras impeditivas do acesso ao rastreio do câncer do colo uterino no âmbito da Saúde da Família do Município de Nova Iguaçu, Rio de Janeiro, Brasil. Por meio de um inquérito domiciliar foram entrevistadas 281 mulheres com idades entre 20 e 59 anos. Para avaliação das barreiras de acesso ao exame, utilizou-se a versão em português do instrumento Champion's Health Belief Model Scale (CHBMS. O medo relacionado ao resultado do exame (39,85%; IC95%: 34,09-45,61 e ao profissional examinador (31,31%; IC95%: 25,86-36,77, a vergonha (39,85%; IC95%: 34,09-45,61 e o esquecimento relacionado ao agendamento do exame (32,02%; IC95%: 26,53-37,51 foram referidos como as principais barreiras impeditivas do acesso. Como os fatores de impedimento variaram de acordo com as características sociodemográficas da população, acredita-se que a estruturação das práticas de rastreio da doença deve ser pautada na realidade territorial.The aim of this study was to analyze barriers to access to cervical cancer screening under the Family Health Program in Nova Iguacu, Rio de Janeiro State, Brazil. Through a household survey, we interviewed 281 women 20 to 59 years of age. To assess barriers to the Pap smear, a Portuguese version of the Champion's Health Belief Model Scale was used. Fear related to the test results (39.85%, 95%CI: 34.09-45.61 and the professional examiner (31.31%, 95%CI: 25.86-36.77, shame (39.85%, 95%CI: 34.09-45.61, and forgetting to schedule the test (32.02%, 95%CI: 26.53-37.51 were reported as the main barriers to access. Since the constraints varied according to the population's socio-demographic characteristics, organization of cervical cancer screening should be tailored accordingly.

  20. A dor na criança com câncer: modelos de avaliação El dolor en niños con cáncer: modelos de evaluación Pain in children with cancer: evaluation models

    Directory of Open Access Journals (Sweden)

    Patrícia Torritesi

    1998-10-01

    Full Text Available O controle e o alívio da dor na assistência à criança com câncer tem sido objeto de preocupação da enfermagem na busca de intervenções que possam minimizar ou evitar problemas de ordem físico-emocional para estas crianças. A literatura da área médica, da psicologia e da enfermagem descrevem a dor através de aspectos fisiológicos, emocionais, comportamentais e ambientais, sendo divulgados vários modelos de escalas de avaliação e de controle da dor. Este estudo descreve alguns modelos de avaliação da dor em crianças e apresenta a adaptação do Modelo de Escala Analógica Visual de Faces de McGrath (1990, como instrumento a ser utilizado na assistência de enfermagem à criança com câncer. Embora a literatura utilizada neste estudo enfatize a avaliação e o controle da dor na criança com câncer, verificamos a viabilidade da aplicação deste modelo pela enfermagem em outras situações de dor.El control y alivio del dolor en la asistencia a niños con cáncer ha sido objeto de inquietud de la enfermería en busca de intervenciones que puedan minimizar o evitar problemas de orden físico-emocional para estos niños. La literatura de las áreas médica, psicología y enfermería describen el dolor a través de aspectos fisiológicos, emocionales, comportamentales y ambientales, siendo divulgados vários modelos de escalas de evaluación y control del dolor. Este estudio describe algunos modelos de evaluación del dolor en niños y presenta la adaptación del Modelo de Escala Analógica Visual de Facetas de McGrath (1990, como instrumento a ser utilizado en la asistencia de enfermería a niños con cáncer. Sin embargo la literatura utilizada en este estudio enfatice la avaluación y el control de el dolor en el niño con cáncer, verificamos la viabilidad de la aplicación de este modelo por el profesional de enfermería en otras situaciones del dolor.Control and alleviation of pain in the care to children with cancer are

  1. The NA48 experiment

    CERN Multimedia

    1995-01-01

    The NA48 experiment is designed to study the Charge-Parity (CP) violation. CP violation is observed in certain very rare decays. Its study is important in understanding Nature's preference of matter over antimatter, which resulted in asymmetry soon after the Big Bang, creating a matter-dominated Universe.

  2. Riso na epilepsia

    Directory of Open Access Journals (Sweden)

    Edymar Jardim

    1967-06-01

    Full Text Available São estudados três casos de síndrome convulsiva temporal, com manifestações concomitantes de riso na sua fase inicial. As características principais foram a imotivação e á incoercibilidade do riso. Esses sintomas desapareceram com o uso de anticonvulsivantes.

  3. Biotecnologia na agricultura

    Directory of Open Access Journals (Sweden)

    Helaine Carrer

    2010-01-01

    Full Text Available A expectativa de o crescimento populacional atingir 9 bilhões de habitantes em 2050 em adição às questões da sustentabilidade e do aquecimento global nos desafiam a aumentar a oferta de alimentos. Uma metodologia alternativa que contribua para a redução do impacto desse cenário envolve a biotecnologia, que, nas últimas décadas, trouxe marcantes oportunidades tecnológicas na agricultura, resultando em relevante desenvolvimento na obtenção de novas variedades de plantas, na melhoria da qualidade de diversos alimentos e atualmente também na bioenergia. As técnicas biotecnológicas envolvendo os marcadores moleculares, a genômica e a transformação genética estão transformando a agricultura e são discutidas neste artigo.The expected population growth to reach 9 billion by 2050 in addition to issues of sustainability and global warming challenges us to increase the supply of food. An alternative approach to help reducing the impact of this scenario involves biotechnology which in recent decades has brought remarkable technological opportunities in the agriculture that resulted in relevant development in obtaining new plant varieties, improved quality of different foods, and now also in bioenergy. The biotechnology techniques involving molecular markers, genomics and genetic transformation are transforming agriculture and will be discussed in this article.

  4. Oncologia de Cabeça e Pescoço: enquadramento epidemiológico e clínico na avaliação da Qualidade de Vida Relacionada com a Saúde Head and Neck Cancer: Health Related Quality of Life Assessment considering clinical and epidemiological perspectives

    Directory of Open Access Journals (Sweden)

    Augusta Silveira

    2012-03-01

    Full Text Available A importância das doenças oncológicas como causa de morbilidade e mortalidade está em crescimento, sendo reconhecido o seu impacto social e peso global pelos custos económicos e sociais envolvidos na sua prevenção, tratamento e reabilitação. As patologias oncológicas de cabeça e pescoço representam um dos seis tumores malignos mais prevalentes em todo o mundo, com um valor estimado de 900.000 novos casos diagnosticados anualmente em escala mundial. Estes doentes oncológicos apresentam deterioração de funções básicas que, quando percepcionadas, têm impacto negativo na sua Qualidade de Vida. Um registo oncológico adequado permite uma análise mais rigorosa dos resultados obtidos na avaliação da Qualidade de Vida Relacionada com a Saúde. Este estudo incluiu 380 doentes oncológicos de cabeça e pescoço e demonstra que as mulheres apresentam resultados de Qualidade de Vida globalmente inferiores. Salienta-se ainda a importância do diagnóstico precoce em oncologia, que se relaciona frequentemente com melhores scores e conclui-se que a localização do tumor tem impacto sobre a autopercepção de Qualidade de Vida. Os valores de Qualidade de Vida Relacionada com a Saúde devem ser interpretados à luz das variáveis sociodemográficas e clínicas, para melhor se avaliar a Patologia Oncológica de Cabeça e Pescoço numa perspectiva epidemiológica no sentido de melhor compreender o processo saúde - doença.The importance of oncology diseases as a cause of morbidity and mortality is increasing worldwide, and their social impact is being recognized due to economic and social costs involved in prevention, treatment and rehabilitation. Head and neck cancer is one of the six most prevalent neoplasms worldwide, with an estimated 900,000 new cases diagnosed annually. Regardless of tumor site, deterioration of basic functions affecting head and neck areas are perceived and affect patients' lives. Appropriate cancer registration may

  5. 6 Common Cancers - Lung Cancer

    Science.gov (United States)

    ... Bar Home Current Issue Past Issues 6 Common Cancers - Lung Cancer Past Issues / Spring 2007 Table of Contents For ... Desperate Housewives. (Photo ©2005 Kathy Hutchins / Hutchins) Lung Cancer Lung cancer causes more deaths than the next ...

  6. 6 Common Cancers - Skin Cancer

    Science.gov (United States)

    ... Bar Home Current Issue Past Issues 6 Common Cancers - Skin Cancer Past Issues / Spring 2007 Table of Contents For ... AP Photo/Herald-Mail, Kevin G. Gilbert Skin Cancer Skin cancer is the most common form of ...

  7. Caracterização da AMPK/mTOR hipotalâmica na anorexia induzida pelo câncer = : Characterization of hypothalamic AMPK/mTOR in cancer-induced anorexia

    OpenAIRE

    Gustavo Duarte Pimentel

    2015-01-01

    A teoria das doenças geradas por citocinas inflamatórias trouxe ao longo dos anos indícios que o organismo pode produzir citocinas que desempenham respostas biológicas benéficas ou prejudiciais. Com o passar dos anos ficou claro que a inflamação é um mecanismo chave na fisiopatologia do câncer. Interessantemente, diversos estudos sugerem que a AMPK e mTOR hipotalâmica, importantes moléculas no controle do balanço energética também seja responsável por modular a inflamação e anorexia. Nesse se...

  8. Preparing for NA4

    CERN Multimedia

    1977-01-01

    Here, in one of the EF workshop, Albert Duchêne works on a pretty piece of mechanics. A few others await to be attended on the left. There are indications that the pipes were meant to house the carbon target (subdivided in eight sections) to be installed inside the toroid magnet of the NA4 experiment. The external strips were designed to possibly correct the magnetic field (???).

  9. História prévia de realização de teste de Papanicolaou e câncer do colo do útero: estudo caso-controle na Baixada Fluminense, Rio de Janeiro, Brasil Previous history of Pap smears and cervical cancer: a case-control study in the Baixada Fluminense, Rio de Janeiro State, Brazil

    Directory of Open Access Journals (Sweden)

    Maria Isabel do Nascimento

    2012-10-01

    Full Text Available Este estudo caso-controle hospitalar foi realizado de 2007 a 2010 para estimar a associação de história prévia de colpocitologia e câncer do colo do útero na Baixada Fluminense, Rio de Janeiro, Brasil. A amostra consistiu de 152 casos histologicamente confirmados e 169 controles selecionados no mesmo hospital dos casos. A análise foi feita de acordo com um modelo em três níveis hierárquicos; considerando as variáveis sociodemográficas (nível distal, sexual/reprodutivas e de estilo de vida (nível intermediário e a história prévia de colpocitologia (nível proximal. Odds ratios (OR e respectivos intervalos de 95% de confiança (IC95% foram calculados pela regressão logística não condicional. Ter história prévia de três ou mais colpocitologias conferiu uma proteção de 84% (OR = 0,16; IC95%: 0,074; 0,384 após ajuste pelas variáveis selecionadas. Os resultados acentuam a importância do exame preventivo ginecológico no risco desse câncer e fortalecem a necessidade de aumentar a aderência às normas do programa brasileiro, bem como de identificar e capturar mulheres relutantes para o rastreamento da doença.This hospital-based case-control study (2007-2010 aimed to estimate the association between previous Pap smear and cervical cancer diagnosis in the Baixada Fluminense, Rio de Janeiro State, Brazil. The sample consisted of 152 histologically confirmed cases and 169 controls from the same hospital as the cases. The analysis was conducted according to a model in three hierarchical levels considering sociodemographic characteristics (distal, sexual/reproductive and lifestyle factors (intermediate, and previous Pap smear (proximal. Odds ratios (OR and respective 95% confidence intervals (95%CI were calculated using unconditional logistic regression. History of three or more Pap smears was associated with an 84% reduction in cervical cancer risk (OR = 0.16; 95%CI: 0.074; 0.384 after adjusting for selected variables. The

  10. Acurácia na reprodutibilidade do posicionamento diário de pacientes submetidos a radioterapia conformada (RT3D para câncer de próstata Accuracy in the reproducibility of daily patients' setup in 3D conformal radiotherapy for prostate cancer

    Directory of Open Access Journals (Sweden)

    Adelmo José Giordani

    2010-08-01

    Full Text Available OBJETIVO: Avaliar a reprodutibilidade do posicionamento de pacientes com diagnóstico de câncer de próstata submetidos a radioterapia conformada. MATERIAIS E MÉTODOS: Foram avaliados 960 (posições anterior e lateral filmes radiológicos, de um total de 120 pacientes que receberam radioterapia conformada na próstata com técnica isocêntrica. As imagens foram obtidas em acelerador linear de partículas 6 MV. Aplicou-se protocolo específico para planejamento e tratamento da próstata, com o paciente em posição supina, mãos colocadas sobre o tórax, pés apoiados em suporte apropriado. Diariamente, os pacientes foram posicionados conforme demarcações na pele, coincidentes com os lasers da sala. Os filmes radiológicos foram comparados com as radiografias reconstruídas digitalmente (digitally reconstructed radiography - DRR em sistema de planejamento computadorizado Eclipse, a partir das tomografias. As radiografias de posicionamento foram realizadas no primeiro dia e após, semanalmente, até o término do tratamento. RESULTADOS: As médias dos deslocamentos observados foram de 1,99 ± 1,25 mm no sentido crânio-caudal, 1,37 ± 0,84 mm no látero-lateral e 1,94 ± 1,10 mm no ântero-posterior. CONCLUSÃO: O uso de protocolos específicos para posicionamento dos pacientes é possível na prática clínica, possibilita reprodutibilidade adequada e rápida correção dos possíveis erros.OBJECTIVE: To evaluate the reproducibility of daily patients' setup in 3D conformal radiotherapy for prostate cancer. MATERIALS AND METHODS: The present study evaluated a total of 960 radiological images (anterior and lateral views of 120 patients submitted to conformal radiotherapy for prostate cancer with the isocentric technique. A 6 MV particle accelerator was utilized in the process. A specific protocol for prostate radiotherapy planning and treatment was applied, with the patients placed in supine position, hands on the chest and legs placed on and

  11. Conhecimento, atitude e práticas na prevenção do câncer de colo uterino e hpv em adolescentes Conocimientos, actitudes y prácticas en la prevención de cáncer cervicouterino y el VPH en adolescentes Knowledge, attitude and practice in the prevention of cervical cancer and HPV in adolescents

    Directory of Open Access Journals (Sweden)

    Ferla Maria Simas Bastos Cirino

    2010-03-01

    Full Text Available O início sexual cada vez mais cedo propicia alta vulnerabilidade da adolescente a problemas da esfera sexual/reprodutiva, incluindo o câncer de colo uterino e a infecção pelo HPV. O presente estudo teve como objetivo identificar o conhecimento, atitude e prática na prevenção do câncer de colo uterino e infecção pelo HPV na população adolescente e avaliar as situações que as tornam vulneráveis. Trata-se de estudo transversal realizado em uma escola pública de São Paulo com 134 adolescentes entre 14 e 19 anos. Verificou-se idade de iniciação sexual aos 14,8 anos em média. Grande parte das adolescentes não apresentou conhecimento adequado sobre a prevenção desta neoplasia. A adesão ao Papanicolaou também se mostrou baixa. As estatísticas justificam a inserção da adolescente nos programas de detecção deste câncer. É preciso haver investimentos na educação sexual nas instituições de ensino e associar campanhas de Papanicolaou com atividades educativas, com enfoque adequado e linguagem apropriada.La iniciación sexual cada vez más temprana propicia un nivel alto de vulnerabilidad de los adolescentes a los problemas de la esfera sexual / reproductiva, incluyendo el cáncer del cuello del útero y la infección por VPH. Este estudio tuvo como objetivo identificar los conocimientos, actitudes y prácticas en la prevención de cáncer cervical y la infección por VPH en la población adolescente y evaluar las situaciones que los tornan vulnerables. Este es un estudio transversal realizado en una escuela pública en Sao Paulo con 134 adolescentes entre 14 y 19 años. El promedio de la edad de iniciación sexual fue de 14,8 años. La mayoría de los adolescentes no tienen conocimientos adecuados sobre la prevención de este tipo de cáncer. También presentó bajas tasas de la prueba del Papanicolaou . Las estadísticas justifican la inclusión de estas adolescentes en los programas para la detección de este cáncer. Es

  12. Prophylactic and therapeutic management of oral complications related to chemotherapy and radiotherapy: role of dental oncology in cancer patient supportive therapy; Manejo profilatico e terapeutico das complicacoes orais associadas a quimioterapia e radioterapia: o papel da odontologia oncologica na terapia de suporte ao paciente com cancer

    Energy Technology Data Exchange (ETDEWEB)

    Buffarah, Henry Bittar [Hospital Sirio-Libanes, Sao Paulo, SP (Brazil). Centro de Oncologia. Servico de Medicina Bucal]. E-mail: hbittar@terra.com.br

    2008-07-01

    Cancer patients under treatment of head and neck tumors as well as those under chemotherapy for hematologic cancers, such as lymphoma and leukemia, and those about to receive bone marrow grafts, do require preventive oral and dental care (prior to cancer treatment), as well as oral care during and after oncological treatment. Furthermore, chemo and radiotherapy-related adverse effects are also common in patients with other types of cancer, with an estimated frequency of 10 per cent in adjuvant chemotherapy (QT), 40 per cent in primary QT, 80 per cent in bone marrow transplantation, in which myeloablative regimens are introduced, and 100 per cent in head and neck radiotherapy, in which the targeted fields are those of the oral cavity. The dentist, specialized in dental oncology, works within the multidisciplinary team at the great centers of cancer treatment, contributing to improve the quality of life of these patients. The present review of literature and of the Guidelines for Management of Oral Complications of Chemotherapy and Head and Neck Radiation (US National Cancer Institute) aims to inform the clinical oncologist, the radio therapist, and other professionals about the resources available in Oral Supportive Therapy in both the prevention and managements of such complications. (author)

  13. A epilepsia na neurocisticercose

    Directory of Open Access Journals (Sweden)

    Luís Marques-Assis

    1972-12-01

    Full Text Available Foram estudados 131 casos de epilepsia com etiologia cisticercótica comprovada. A idade variou de 2 a 68 anos; 75 pacientes eram de sexo masculino e 56 de sexo feminino; 117 eram brancos, 10 pardos, três pretos e um amarelo. A idade de início da doença predominou na primeira década. O estudo foi feito em relação ao tipo de epilepsia, ao tempo decorrido após a primeira crise, à freqüência das crises e ao eletrencefalograma relativamente às epilepsias em geral. Investigação foi feita também em relação à cefaléia, aos achados neurológicos, liquóricos, radiológicos simples e contrastados e anátomo-patológicos. A análise dos resultados permitiu aos autores as seguintes conclusões: 1 No grupo de neurocisticercose o início da doença predominou na primeira e a partir da quarta década em relação às epilepsias em geral. 2 Dentre as manifestações clínicas predominaram as formas convulsivas da doença (61%, sendo as crises bravas-jacksonianas as menos freqüentes (4%; quando comparadas com as epilepsias em geral, verifica-se incidência menor das convulsões generalizadas na neurocisticercose. 3 Quanto ao tempo de doença, verifica-se predomínio das formas de duração mais curta (um ano ou menos na neurocisticercose. 4 A severidade da epilepsia, traduzida pela freqüência das crises, foi menor no grupo com neurocisticercose. 5 Excluídos os casos com anormalidades eletrencefalográficas contínuas, foram encontrados maiores índices percentuais de EEG normal na neurocisticercose que nas epilepsias em geral. 6 A cefaléia estava presente em 68% dos casos, assumindo caráter paroxístico na maior parte (78%; em 67% dos casos com cefaléia paroxística não havia concomitantemente sinais de hipertensão intracraniana; nos casos com cefaléia contínua, em apenas dois (13% esses sinais não estavam presentes. 7 Na maior parte dos casos (62% as manifestações epilépticas se apresentaram isoladamente, sem sinais neurol

  14. Influência da terapêutica hormonal prévia sobre os indicadores de prognóstico do câncer de mama em mulheres na pós-menopausa Influence of previous hormonal therapy on breast cancer prognostic markers in postmenopausal women

    Directory of Open Access Journals (Sweden)

    Eliana Aguiar Petri Nahas

    2005-03-01

    Full Text Available OBJETIVO: avaliar a influência da terapêutica hormonal (TH prévia sobre alguns indicadores de prognóstico do câncer de mama, em pacientes na pós-menopausa. MÉTODOS: estudo transversal por meio da aplicação de questionários e levantamento de prontuários. Foram entrevistadas 157 pacientes com diagnóstico de câncer de mama na pós-menopausa, registrando-se dados clínicos, antecedentes pessoais e familiares, uso de TH e mamografias. Nos prontuários foram obtidas informações sobre o câncer de mama quanto ao diâmetro do tumor, tipo de cirurgia e estudo imuno-histoquímico. Para a estatística empregou-se ANOVA e teste do chi2. RESULTADOS: 38,2% das pacientes eram ex-usuárias de TH e 61,8% não usuárias. O tempo médio de uso da TH foi de 3,7±3,6 anos. As ex-usuárias eram de menor faixa etária e com menor tempo de menopausa quando comparadas às não usuárias (pPURPOSE: to evaluate the influence of previous hormonal therapy (HT on breast cancer prognostic markers in postmenopausal women. Methods: a cross-sectional study was carried out, applying questionnaires and medical record surveys of 157 postmenopausal patients with breast cancer diagnosis. Clinical data, personal and familiar history, HT use, and mammograms were investigated. The medical record surveys yielded information about tumor size, imunohistochemical data, and type of surgery. Statistical analysis was performed using ANOVA and the chi2 test. RESULTS: 38.2% of the patients were HT ex-users and 61.8% were non-users. Mean time of HT use was 3.7±3.6 years. HT ex-users were younger and with a shorter menopause time than non-users (p<0.05. 26.8% of the patients reported previous cases of breast cancer in their families, with no difference between the groups. Of the HT ex-users, 43.3% had previous mammograms, while of the non-users, only 11.3% (p<0.001. Mean tumor size was smaller in HT ex-users (2.3±1.1 cm than in non-users (3.3±1.5cm (p<0.001. The conservative

  15. The European Medicines Agency Review of Abiraterone for the Treatment of Metastatic Castration-Resistant Prostate Cancer in Adult Men After Docetaxel Chemotherapy and in Chemotherapy-Naïve Disease: Summary of the Scientific Assessment of the Committee for Medicinal Products for Human Use

    Science.gov (United States)

    Lopez, Arantxa Sancho; Hemmings, Robert James; Jiménez, Jorge Camarero; Garcia-Carbonero, Rocio; Gallego, Isabel García; Giménez, Elena Valencia; O'Connor, Daniel; Giuliani, Rosa; Salmonson, Tomas; Pignatti, Francesco

    2013-01-01

    On September 5, 2011, abiraterone was approved in the European Union in combination with prednisone or prednisolone for the treatment of metastatic castration-resistant prostate cancer (CRPC) in adult men whose disease has progressed on or after a docetaxel-based chemotherapy regimen. On December 18, 2012, the therapeutic indication was extended to include the use of abiraterone in combination with prednisone or prednisolone for the treatment of metastatic CRPC in adult men who are asymptomatic or mildly symptomatic after failure of androgen deprivation therapy in whom chemotherapy is not yet clinically indicated. Abiraterone is a selective, irreversible inhibitor of cytochrome P450 17α, an enzyme that is key in the production of androgens. Inhibition of androgen biosynthesis deprives prostate cancer cells from important signals for growth, even in cases of resistance to castration. At the time of European Union approval and in a phase III trial in CRPC patients who had failed at least one docetaxel-based chemotherapy regimen, median overall survival for patients treated with abiraterone was 14.8 months versus 10.9 months for those receiving placebo (hazard ratio, 0.65; 95% confidence interval 0.54–0.77; p < .0001). In a subsequent phase III trial in a similar but chemotherapy-naïve patient population, median radiographic progression-free survival was 16.5 months for patients in the abiraterone treatment arm versus 8.3 months for patients in the placebo arm (hazard ratio, 0.53; 95% confidence interval, 0.45–0.62; p < .0001). Abiraterone was most commonly associated with adverse reactions resulting from increased or excessive mineralocorticoid activity. These were generally manageable with basic medical interventions. The most common side effects (affecting more than 10% of patients) were urinary tract infection, hypokalemia, hypertension, and peripheral edema. PMID:23966222

  16. Análisis del proceso de minería de datos sobre la base de datos Bioinformática de segmentos de la proteína p53, asociada a la actividad cancerígena

    Directory of Open Access Journals (Sweden)

    Alejandro Hadad

    2011-11-01

    Full Text Available Se estudió la utilización de estrategias para afrontar el problema del desbalanceo y la alta dimensionalidad de los registros que habitualmente forman parte de las bases de datos en el área bioinformática. Se tomó como caso de estudio la base de datos de segmentos de la proteína p53; sobre dicha base se construyen modelos con el fin de identificar si corresponden a patrones activos o inactivos. El problema del desbalanceo se abordó a través de una red neuronal no supervisada, y el de la selección de variables para reducir la alta dimensionalidad, a partir de una combinación de métodos con diferentes enfoques. Experimentos preliminares del modelo propuesto en datos estándar muestran resultados promisorios.

  17. Report from NA49

    CERN Document Server

    Gazdzicki, M; Anticic, T; Baatar, B; Barna, D; Bartke, Jerzy; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Brun, R; Buncic, P; Cerny, V; Christakoglou, P; Chvala, O; Cramer, J G; Csató, P; Darmenov, N; Dimitrov, A; Dinkelaker, P; Eckardt, V; Farantatos, G; Filip, P; Flierl, D; Fodor, Z; Foka, P Y; Freund, P; Friese, V; Gál, J; Georgopoulos, G; Gladysz-Dziadus, E; Grebieszkow, K; Hegyi, S; Höhne, C; Kadija, K; Karev, A; Kliemant, M; Kniege9, S; Kolesnikov, V I; Kollegger, T; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; Van Leeuwen, M; Lévai, Peter; Litov, L; Lungwitz, B; Makariev, M; Malakhov, A I; Markert, C; Mateev, M; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Mitrovski, M; Molnár, J; Mrówczynski, S; Pálla, G; Panagiotou, A D; Panayotov, D; Petridis, A; Pikna, M; Pinsky, L; Pühlhofer, F; Reid, J G; Renfordt, R E; Richard, A; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Sann, H; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Stefanek, G; Stock, R; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Trainor, T A; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wetzler, A; Wlodarczyk, Z; Yoo, I K; Zaranek, J; Zimányi, J

    2004-01-01

    The most recent data of NA49 on hadron production in nuclear collisions at CERN SPS energies are presented. Anomalies in the energy dependence of pion and kaon production in central Pb+Pb collisions are observed. They suggest that the onset of deconfinement is located at about 30 AGeV. Large multiplicity and transverse momentum fluctuations are measured for collisions of intermediate mass systems at 158 AGeV. The need for a new experimental programme at the CERN SPS is underlined.

  18. A escola na internet

    OpenAIRE

    Albino, Ayrán Lavra

    2003-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção. O presente trabalho pretendeu analisar o uso do suporte tecnológico do ensino a distância (computador e internet) como elemento complementar do ensino presencial. Procurou-se demonstrar, na fundamentação teórica, que as tendências pedagógicas contemporâneas e as características da tecnologia digital viabilizam esta possibilidade. Operacionalizou-se essa ...

  19. Fractais na arquitectura

    OpenAIRE

    2009-01-01

    Uma forma de inovar na simplicidade, em Arquitectura, é usar a geometria dos fractais. Uma técnica simples de iterativamente chegar a formas fantásticas e muito agradáveis de integrar no desenho de uma obra de arte: sejam edifícios, pontes, jardins, e outros. Vamos abordar o conceito essencial da geometria dos fractais e analisar exemplos da sua aplicação em edifícios e cidades. Para isso faz-se uma introdução ao tema pelos primórdios da geometria fractal referindo exemplos como o Co...

  20. na Perua

    Directory of Open Access Journals (Sweden)

    Jorge Carvalho

    1989-01-01

    Full Text Available Antes de se caracterizar como tentativa de ensaio ou de análise a qualquer coisa, o presente artigo tem, antes de mais nada, a pretensão de se constituir uma provocação ao debate acerca da questão do esporte na escola. A provocação parte basicamente do relato da minha experiência pessoal como Secretário da Educação do Município de Aracaju, cargo que exerci no período de 1º de janeiro de 1986 a 27 de janeiro de 1987.

  1. Itinerário percorrido pelas mulheres na descoberta do câncer Camino recorrido por las mujeres en la descubierta del cáncer The journey experienced by women through a cancer diagnosis

    Directory of Open Access Journals (Sweden)

    Maria Aparecida Salci

    2009-09-01

    , por consiguiente, garantizar un mejor pronóstico y una mejor calidad de vida.This study intends to reveal the journey experienced by women in the process of facing a cancer diagnosis. Symbolic Interactionism and Grounded Theory were used as theoretical-methodological strategies. Twenty individuals took part in the study - 10 female cancer bearers and their respective significant others. The results are described starting from the moment they experience their first perceptions of the physiologic changes in their bodies, through the search for professional help, to the acknowledgement of a cancer diagnosis. The given itinerary presents aspects of the patients' reality prior to the diagnosis, and emphasizes the importance of professionals giving more credence to the complaints of patients who seek them if the patient made an appointment, it is because that person is concerned. This attitude can promote the early identification of the problem, and consequently guarantee a better prognosis and quality of life.

  2. Childhood Cancer

    Science.gov (United States)

    ... Cancer? Cancer Treatment Coping With Cancer en español Cáncer infantil Every cell in the body has a system that controls its growth, interaction with other cells, and even its life span. ... cancer . Different kinds of cancer have different signs, symptoms, ...

  3. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Information Advance Directives Using Trusted Resources Cancer Types Adolescents and Young Adults with Cancer Reports, Research, and ... of Cancers Cancers by Body Location Childhood Cancers Adolescent & Young Adult Cancers Metastatic Cancer Recurrent Cancer Research ...

  4. What Is Thymus Cancer?

    Science.gov (United States)

    ... Cancer? Thymus Cancer About Thymus Cancer What Is Thymus Cancer? Cancer starts when cells in the body ... Research and Treatment for Thymus Cancer? More In Thymus Cancer About Thymus Cancer Causes, Risk Factors, and ...

  5. Comprometimento pulmonar na leptospirose

    Directory of Open Access Journals (Sweden)

    Jorge Eduardo Manhães de Carvalho

    1992-03-01

    Full Text Available Em 23 pacientes com leptospirose apresentando comprometimento pulmonar, internados no Hospital Universitário Antônio Pedro da XJFF, Niterói, hemoptise e hemoptóicos foram observados em 21,7% e 30,4%, respectivajnente. Gasometria arterial revelou hipoxemia e hipocapnia na maioria dos casos. Radiografia de tórax em 15 pacientes mostrou comprometimento alveolar em 60%, comprometimento intersticial-reticular em 6%, padrão misto (alveolar e intersticial em20%e ausência de alterações radiológicas em 14%. A necrópsiade 13 pacientes mostrou edema, congestão e hemorragia nos pulmões em 100% dos casos. A hemorragia foi focal em 46% e difusa em 54% dos casos. Houve formação de membrana hialina em 30% e trombos de fibrina em 46% dos pulmões estudados, o que estabelece o diagnóstico da coagulação intravascular disseminada e a ocorrência da síndrome de angústia respiratória na leptospirose.

  6. Laser na medicina: avanços na Oftalmologia

    OpenAIRE

    João Alberto Holanda de Freitas

    2007-01-01

    Entre os grandes avanços tecnológicos dos últimos anos, o laser sem dúvida ocupa lugar de destaque. Desde a construção do primeiro aparelho a laser em 1959, novas aplicações surgem continuadamente. O laser está presente de maneira marcante na pesquisa básica, na indústria e na medicina.

  7. Importância da dieta na epidemiologia do câncer de colon e reto The importance of diet in the epidemiology of cancer of the colon and rectum

    Directory of Open Access Journals (Sweden)

    Eliza da Conceição da Fonseca Lopes

    1984-10-01

    Full Text Available Foi feita atualização de estudos realizados com o objetivo de verificar a relação entre o fator ambiental, destacando-se a alimentação caracterizada por uma dieta pobre em fibra e rica em gordura e a distribuição epidemiológica do câncer de colon e reto. São enfatizadas as diferenças apresentadas pelas dietas dos países industrializados e dos países em desenvolvimento e a influência da religião e do fluxo migratório no hábito alimentar, associadas com as taxas de incidência da doença.Studies have been made to verify the relation between the environmental factor, diet rich in fat and deficient in fibre, and the epidemiologic distribution of cancer of the colon and rectum. The research emphasizes the differences between the diets of the industrialized and the developing countries, and the influence of religion and migratory movements on the diet usualy associated with incidence of the disease.

  8. Penile cancer

    Science.gov (United States)

    Cancer - penis; Squamous cell cancer - penis; Glansectomy; Partial penectomy ... Cancer of the penis is rare. Its exact cause is unknown. However, certain risk factors include: Uncircumcised men who don't keep the ...

  9. Cancer Chemotherapy

    Science.gov (United States)

    ... controlled way. Cancer cells keep growing without control. Chemotherapy is drug therapy for cancer. It works by killing the cancer ... It depends on the type and amount of chemotherapy you get and how your body reacts. Some ...

  10. Skin Cancer

    Science.gov (United States)

    ... the head, face, neck, hands, and arms. Another type of skin cancer, melanoma, is more dangerous but less common. Anyone ... cancer is found early. If not treated, some types of skin cancer cells can spread to other tissues and organs. ...

  11. Testicular cancer

    Science.gov (United States)

    Testicular cancer is cancer that starts in the testicles, the male reproductive glands located in the scrotum. ... developing testicular cancer increases if he has: Abnormal testicle development Exposure to certain chemicals Family history of ...

  12. Ovarian Cancer

    Science.gov (United States)

    ... deaths than other female reproductive cancers. The sooner ovarian cancer is found and treated, the better your chance for recovery. But ovarian cancer is hard to detect early. Women with ovarian ...

  13. Cancer Moonshot

    Science.gov (United States)

    The Cancer Moonshot, led by Vice President Joe Biden, will marshal resources across the federal government to speed progress in cancer research and lead to improved cancer prevention, detection, and treatment.

  14. Uterine Cancer

    Science.gov (United States)

    ... is pregnant. There are different types of uterine cancer. The most common type starts in the endometrium, ... the uterus. This type is also called endometrial cancer. The symptoms of uterine cancer include Abnormal vaginal ...

  15. Thyroid Cancer

    Science.gov (United States)

    ... body work normally. There are several types of cancer of the thyroid gland. You are at greater ... imaging tests, and a biopsy to diagnose thyroid cancer. Treatment depends on the type of cancer you ...

  16. Stomach Cancer

    Science.gov (United States)

    ... with stomach acid and helps digest protein. Stomach cancer mostly affects older people - two-thirds of people ... Smoke cigarettes Have a family history of stomach cancer It is hard to diagnose stomach cancer in ...

  17. Bone Cancer

    Science.gov (United States)

    Cancer that starts in a bone is uncommon. Cancer that has spread to the bone from another ... more common. There are three types of bone cancer: Osteosarcoma - occurs most often between ages 10 and ...

  18. Cancer Immunotherapy

    Science.gov (United States)

    Immunotherapy is a cancer treatment that helps your immune system fight cancer. It is a type of biological therapy. Biological therapy uses substances ... t yet use immunotherapy as often as other cancer treatments, such as surgery, chemotherapy, and radiation therapy. ...

  19. Throat Cancer

    Science.gov (United States)

    ... food. Surgery to remove cancerous lymph nodes (neck dissection). If throat cancer has spread deep within your ... neck cancers. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2015. Freedman ND, et al. Fruit ...

  20. Existe diferença no estadiamento entre doentes operados de câncer colorretal no sistema previdenciário e na clinica privada? There is any difference in staging between patients operated on for colorectal cancer in public or private hospital?

    Directory of Open Access Journals (Sweden)

    Rodrigo Cuiabano Paes Leme

    2007-06-01

    Full Text Available OBJETIVO: Avaliar se existe diferença no estadiamento de doentes submetidos à ressecção intestinal por câncer colorretal no sistema previdenciário e na clínica privada. MÉTODO: Foram estudados de forma retrospectiva 41 doentes (16 homens e 25 mulheres com idade média de 59,4 anos operados no sistema previdenciário (SP e 33 doentes (18 homens e 15 mulheres com idade média de 60,8 anos operados na clínica privada (CP. Foram avaliados o estadiamento TNM, a frequência de operações de urgência, de operações paliativas e do uso de colostomia. RESULTADOS: Não se observou diferença entre o estadiamento dos dois grupos. A frequência de operações de urgência foi 26,8% no SP e 12,1% na CP (p=0,100. As operações paliativas ( 19,5% SP x 6,1% CP e o uso de colostomia ( 26,8 SP X 15,2 CP foram maiores no sistema previdenciário porém os valores não foram estatisticamente significantes, valores de p=0,087 e p=0,352 respectivamente. CONCLUSÃO: Não há diferença significante entre o estadiamento TNM de doentes operados no sistema previdenciário e privado.BACKGROUND: To examine whether there is any difference in staging between patients operated on for colorectal cancer in public or private hospital. METHODS: This study included 41 patients (16 men and 25 women, mean age of 59.4 years old who underwent colorectal resection for adenocarcinoma in public hospital (PU and 33 patients (18 men and 15 women, mean age 60.8 years old operated in private hospital (PR. They were evaluated regarding the TNM stage, mode of presentation (elective or emergency, type of resection (curative or palliative and the use of colostomy. RESULTS: There was no significant difference in the staging among the two groups. Emergency presentation were 26.8% in the PU group and 12.1% in the PR group (p=0.100. Palliative resection (19.5% PU x 6.1% PR and the use of colostomy (26.8% PU X 15.2% PR were more frequently in the patients operated in public hospital but

  1. Efeito da continuidade da fisioterapia respiratória até a alta hospitalar na incidência de complicações pulmonares após esofagectomia por câncer Effect of sustained respiratory care until hospital discharge on the incidence of pulmonary complications following esophagectomy for cancer

    Directory of Open Access Journals (Sweden)

    Adriana Claudia Lunardi

    2008-01-01

    Full Text Available O presente estudo avaliou os efeitos na incidência de complicações pulmonares do cuidado contínuo de fisioterapia respiratória no pós-operatório de esofagectomia, até a alta hospitalar. Examinaram-se retrospectivamente 40 prontuários de pacientes de esofagectomia consecutivos (nenhuma exclusão, que foram divididos em dois grupos: um dos que receberam fisioterapia respiratória apenas na unidade de tratamento intensivo (gUTI, n=20 e outro dos que a receberam até a alta hospitalar (gALTA, n=20. Foram coletadas informações referentes ao pré, intra e pós-operatório. Os resultados mostram que gUTI e gALTA, respectivamente, apresentaram-se similares (média±dp quanto a idade (55,5±9,9 e 57,1±10,8 anos, IMC (22,5±3,3 e 18±4 kg/m², tempo de cirurgia (400±103,8 e 408,5±142 min, tempo de anestesia (498,3±107,3 e 516±148,9 min e número de atendimentos de fisioterapia na UTI (9,6±14,9 e 8,3±7,6. Apesar de o gALTA apresentar história de tabagismo superior (35,7±17,6 vs 26,1±18,4 maços-ano, pThis study assessed the effects of chest physical therapy all through hospital stay until discharge onto the incidence of pulmonary complications in patients having undergone esophagectomy for cancer. Medical records of esophagectomy patients were examined and 40 subsequent ones selected (none excluded, and divided into two groups: one having received chest physiotherapy only in the intensive care unit (ICUg, n=20 and the other having received it during full hospital stay (DISg, n=20. Information concerning pre-, peri- and postoperative periods were drawn from patients' records. Results show that ICUg and DISg were similar (mean±sd concerning age (55.5±9.9 vs 57.1±10.8 years old, BMI (22.5±3.3 vs 18±4 kg/m², operating time (400±103.8 vs 408.5±142 min, anesthesia time (498.3±107.3 vs 516±148.9 min and number of chest physical therapy sessions in the ICU (9.6±14.9 vs 8.3±7.6 sessions. Despite the fact that DISg patients had

  2. Na Cauda do Cometa

    Science.gov (United States)

    Voelzke, M. R.

    2009-01-01

    Quando viam um cometa, os antigos gregos imaginavam uma estrela com uma vasta cabeleira. Não à toa, a palavra deriva do termo koma, que significa cabelo. Constituídos por fragmentos de gelo e gases, os cometas possuem um núcleo sólido, que pode ter vários quilômetros de diâmetro, e uma cauda que sempre aponta na direção contrária ao Sol, devido aos ventos solares. Graças à aparência de pontos luminosos em movimento (ao contrário de outros astros, que parecem estáticos), esses corpos celestes foram interpretados por diferentes povos com muito misticismo, inspirando mitos tanto de boas-novas como de maus presságios. Conheça algumas dessas histórias:

  3. Raytracing na GPU

    OpenAIRE

    Straňák, Marek

    2011-01-01

    Raytracing je základnou technikou pro vizualizaci trojrozměrných objektů. Cílem práce je demonstrovat možnost implementace sledovaní paprsků pomocí grafického akcelerátoru.  Popíšem základní algoritmus a jeho modifikovanou verzi, která byla implementována pomocí jazyka CUDA C. Výsledný raytracer je optimalizovaný pro dynamické scény. Pro tento účel byla použita akcelerační struktura KD strom, hierarchické obalové tělesa a přenos dat pomocí PBO. Pro realističtější výstupy byla také implementov...

  4. Leadeship: na effective relationship

    OpenAIRE

    Sergio Roberto Guimarães Pantoja

    2005-01-01

    Resumo: O presente trabalho tem por objetivo analisar a eficácia da liderança em três instituições de ensino superior em São Luís -MA, sendo a instituição A (particular), a B (pública federal) e a C (pública estadual). Adotou-se os estilos de liderança: democrático, autocrático e liberal, baseando-se na Teoria dos Estilos de Kurt Lewin e seus colaboradores e nas qualidades de liderança (objetividade, compreensão dos outros, flexibilidade, comunicação e autoridade), definidas por Uris A.(196...

  5. NA48 prototype calorimeter

    CERN Document Server

    1990-01-01

    This is a calorimeter, a detector which measures the energy of particles. When in use, it is filled with liquid krypton at -152°C. Electrons and photons passing through interact with the krypton, creating a shower of charged particles which are collected on the copper ribbons. The ribbons are aligned to an accuracy of a tenth of a millimetre. The folding at each end allows them to be kept absolutely flat. Each shower of particles also creates a signal in scintillating material embedded in the support disks. These flashes of light are transmitted to electronics by the optical fibres along the side of the detector. They give the time at which the interaction occurred. The photo shows the calorimeter at NA48, a CERN experiment which is trying to understand the lack of anti-matter in the Universe today.

  6. O real na psicose

    Directory of Open Access Journals (Sweden)

    Maurício Castejón Herrmann

    2004-06-01

    Full Text Available Este artigo discute a noção de real na psicose, a partir das formulações de Lacan sobre o tema, presentes no Seminário 3 - As Psicoses, no Seminário 20 - Mais, Ainda e no texto Televisão. Considerando-se que a concepção de real tem uma indicação clínica, a hipótese que se formula é a de que a noção de real trabalhada no Seminário 20, Mais, Ainda representa uma continuidade da concepção de real desenvolvida no Seminário 3, As Psicoses

  7. Sequential growth of sandwiched NaYF{sub 4}:Yb/Er@NaYF{sub 4}:Yb@NaNdF{sub 4}:Yb core–shell–shell nanoparticles for photodynamic therapy

    Energy Technology Data Exchange (ETDEWEB)

    Peng, Huang-Yong; Ding, Bin-Bin; Ma, Yin-Chu [Department of Medical Materials and Rehabilitation Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009 (China); Sun, Shi-Qi [State Key Laboratory of Veterinary Etiological Biology and Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou, Gansu 730046 (China); Tao, Wei [Department of Medical Materials and Rehabilitation Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009 (China); Guo, Yan-Chuan [Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190 (China); Guo, Hui-Chen, E-mail: ghch-2004@hotmail.com [State Key Laboratory of Veterinary Etiological Biology and Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou, Gansu 730046 (China); Yang, Xian-Zhu, E-mail: yangxz@hftu.edu.cn [Department of Medical Materials and Rehabilitation Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009 (China); Qian, Hai-Sheng, E-mail: shqian@hfut.edu.cn [Department of Medical Materials and Rehabilitation Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009 (China)

    2015-12-01

    Graphical abstract: The monodisperse elliptical NaYF{sub 4}:Yb/Er@NaYF{sub 4}:Yb@NaNdF{sub 4}:Yb core–shell–shell nanoparticles have been synthesized successfully by a facile sequential growth process, which can be used as transducer for photodynamic therapy of cancer cells. - Highlights: • The NaYF{sub 4}:Yb/Er@NaYF{sub 4}:Yb@NaNdF{sub 4}:Yb nanoparticles have been fabricated successfully. • The as-prepared nanoparticles show strong fluorescence excited at 980 or 808 nm. • The nanoparticles were transferred into the aqueous phase via a facile process. • Photosensitizers were loaded into the composites for photodynamic therapy. - Abstract: Upconversion (UC) nanostructures have attracted much interest for their extensive biological applications. In this work, we describe a sequential synthetic route to prepare sandwiched NaYF{sub 4}:Yb/Er@NaYF{sub 4}:Yb@NaNdF{sub 4}:Yb core–shell upconversion nanoparticles. The as-prepared products were investigated by X-ray diffraction (XRD) and transmission electron microscopy (TEM, JEM 2100F), respectively. The as-prepared core–shell nanoparticles of NaYF{sub 4}:Yb/Er@NaYF{sub 4}:Yb@NaNdF{sub 4}:Yb are composed of elliptical nanoparticles with a length of 80 nm and width of 42 nm, which show efficient upconversion fluorescence excited at 808 nm indicating the formation of core–shell–shell sandwiched nanostructures. In addition, the as-prepared sandwiched NaYF{sub 4}:Yb/Er@NaYF{sub 4}:Yb@NaNdF{sub 4}:Yb core–shell upconversion nanoparticles also show strong upconversion fluorescence excited at 980 nm. Amphiphilic mPEG{sub 2k}-b-PEBEP{sub 6K} copolymers (denoted as PPE) were chosen to transfer these hydrophobic UCNPs into the aqueous phase for biological application. In vitro photodynamic therapy of cancer cells show that the viability of cells incubated with the nanoparticles loaded with MC 540 was significantly lower as compared to the nanoparticles without photosensitizers exposed to NIR laser.

  8. Comprometimento pulmonar na leptospirose

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    Jorge Eduardo Manhães de Carvalho

    1992-03-01

    Full Text Available Em 23 pacientes com leptospirose apresentando comprometimento pulmonar, internados no Hospital Universitário Antônio Pedro da XJFF, Niterói, hemoptise e hemoptóicos foram observados em 21,7% e 30,4%, respectivajnente. Gasometria arterial revelou hipoxemia e hipocapnia na maioria dos casos. Radiografia de tórax em 15 pacientes mostrou comprometimento alveolar em 60%, comprometimento intersticial-reticular em 6%, padrão misto (alveolar e intersticial em20%e ausência de alterações radiológicas em 14%. A necrópsiade 13 pacientes mostrou edema, congestão e hemorragia nos pulmões em 100% dos casos. A hemorragia foi focal em 46% e difusa em 54% dos casos. Houve formação de membrana hialina em 30% e trombos de fibrina em 46% dos pulmões estudados, o que estabelece o diagnóstico da coagulação intravascular disseminada e a ocorrência da síndrome de angústia respiratória na leptospirose.Tostudy thepulmonary complications in leptospirosis case records of 23 such patients admitted at the Hospital Universitário Antônio Pedro, Universidade Federal Fluminense, Niterói, Brasil, were reviewed. Hemoptysis were seen in 21.7% and sputal blood in 30.4% of patients. Arterial gasometry detected hypoxemia and hypocapnia in most cases. Thoracic radiology showed an alveolar pattern in 60% of the patients, alveolo-interstitial in 20%, interstitial in 6%, and in 14% the lungs were considered to be normal Necropsy of 13 cases showed edema, congestion and hemorrhage in the lungs in all cases. Hyaline membrane was found in 30% and fibrin thrombi in 46% of these cases, resulting in a diagnosis of adult respiratory distress syndrome and acute disseminated intravascular coagulation (consumption coagulopathy in leptospirosis.

  9. A ENGENHARIA NA ESCOLA

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    Valéria Pelizzer Casara

    2015-04-01

    Full Text Available Este projeto teve por objetivo principal mostrar às jovens do ensino médio, como as áreas de exatas e de engenharia podem estar inseridas em situações rotineiras por elas vivenciadas e incentivá-las para ingressarem nessas áreas. O projeto foi executado na escola de ensino Médio Nelson Horostecki na cidade de Chapecó, Santa Catarina. Mostrou-se de forma simples que as áreas de exatas e de engenharia têm aplicações práticas nas nossas vidas. No desenvolvimento do projeto, realizaram-se oficinas na escola cujo tema principal abordado foi o processo de fabricação do chocolate, visto que o mesmo é um produto muito apreciado pelas adolescentes. Dentro dessa temática, foram trabalhadas as questões que envolvem conhecimentos das áreas de exatas e de engenharia, mais especificamente a Engenharia Ambiental. O projeto auxiliou na formação cidadã e também na escolha profissional das meninas. Muitas das alunas participantes nunca haviam tido contato direto com alunos graduandos de cursos na área das exatas. Mais ainda, este projeto oportunizou a aproximação da universidade com a comunidade externa. Palavras-chave: Extensão Universitária, Ciências Exatas e Engenharia, Chocolate, Oficinas.   Engineering in the school Abstract: The main objective of this project was to show high school female students how the exact sciences and engineering can be included in their routine situations encouraging them to entering in these areas. The project was carried out at the Nelson Horostecki High School in Chapecó, Santa Catarina State, Brazil. It was showed in a simple manner how exact sciences and engineering have practical applications in our lives. Workshops were conducted in the school during the execution of the project in which the main subject was the chocolate manufacturing process, since chocolate is a product greatly appreciated by the young female people. Within this matter, the activities were performed using the knowledge of

  10. Evaluation of the frequency of polymorphisms in XRCC1 (Arg399Gln) and XPD (Lys751Gln) genes related to the genome stability maintenance in individuals of the resident population from Monte Alegre, PA/Brazil municipality; Avaliacao da frequencia de polimorfismos nos genes XRCC1 (Arg399Gln) e XPD (Lys751Gln) relacionados a manutencao da estabilidade do genoma em individuos da populacao residente no municipio de Monte Alegre, PA

    Energy Technology Data Exchange (ETDEWEB)

    Duarte, Isabelle Magliano

    2010-07-01

    The human exposure to ionizing radiation coming from natural sources is an inherent feature of human life on Earth. Ionizing radiation is a known genotoxic agent, which can affect biological molecules, causing DNA damage and genomic instability. The cellular system of DNA repair plays an important role in maintaining genomic stability by repairing DNA damage caused by genotoxic agents. However, genes related to DNA repair may have their role committed when presenting a certain polymorphism. This study intended to analyze the frequency of single nucleotide polymorphisms (SNPs) in genes of DNA repair XRCC1 (Arg39-9Gln) and XPD (Lys751Gln) in a: population of the city of Monte Alegre, that resides in an area of high exposure to natural radioactivity. Samples of saliva were collected from individuals of the population of Monte Alegre, in which 40 samples were of male and 46 female. Through the use of RFLP (length polymorphism restriction fragment) the frequency of homozygous genotypes and / or heterozygous was determined for polymorphic genes. The XRCC1 gene had 65.4% of the presence of the allele 399Gln and XPD gene had 32.9% of the 751Gln allele. These values are similar to those found in previous studies for the XPD gene, whereas XRCC1 showed a frequency much higher than described in the literature. The. influence of these polymorphisms, which are involved in DNA repair and consequent genotoxicity induced by radiation depends on dose and exposure factors such as smoking, statistically a factor in public health surveillance in the region. This study gathered information and molecular epidemiology for risk assessment of cancer in the population of Monte Alegre. (author)

  11. A difícil convivência com o câncer: um estudo das emoções na enfermagem oncológica A hard relation with cancer: a study of emotions on oncologic's nursing

    Directory of Open Access Journals (Sweden)

    Noeli Marchioro Liston Andrade Ferreira

    1996-08-01

    Full Text Available O presente estudo é uma tentativa de verificar quais as emoções presentes no trabalho de Enfermagem com o paciente oncológico e identificar de que forma elas são enfrentadas pelos enfermeiros no dia-a-dia da assistência de Enfermagem. Para alcance deste objetivo, foi inicialmente feita a opção por uma abordagem quantitativa que permitisse a contextualização da população estudada e a de suas condições de trabalho. A partir desses dados, foi realizado um aprofundamento da questão com a utilização de metodologia qualitativa, através de técnicas de entrevistas estruturadas e semi- estruturadas, bem como da realização de observação de campo. A análise temática dos discursos dos enfermeiros permitiu a identificação dos núcleos de sentidos que foram destacados pela elaboração dos Mapas de Associação de Idéias, sendo eles: a doença, o paciente, a equipe e a instituição, as emoções emergentes e as formas de enfrentamentos. Estes dados nos permitiu identificar as emoções apresentadas no dia a dia da assistência de enfermagem, as formas como enfrentam as situações consideradas difíceis e a mediação da cultura institucional como elemento controlador da expressão emocional.The present study represents an attempt to verify which emotions are present in nursing activities with cancer patients and how nurses deal with them. In order to reach this goal, a quantitative approach was used in order to allow a comprehension of the population studied and their work conditions. After that, field observations and structured and semiestructured interviews were carried out so as to understand how emotion was experienced and dealt with.Thematic analysis of the nurses discourse was conducted in order to identify the core of the emotional issues and to elaborate the Maps of Association of ideas. The main themes were: the disease, the patient, the team and the health instituition, the emotions that emerged and ways of coping

  12. Importância prognóstica da invasão neural no câncer colorretal: estudo imunoistoquímico com a proteína S-100 Prognostic importance of neural invasion in colorectal cancer: an immunohistochemical study with the S-100 protein

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    José Vinícius Cruz

    2006-09-01

    Full Text Available Das variáveis anatomopatológicas relacionadas ao prognóstico de enfermos com câncer colorretal, a invasão neural ainda se encontra pouco estudada. OBJETIVO: Verificar se a invasão neural no câncer colorretal estádios B e C de Dukes pode ser considerada como fator prognóstico independente. MÉTODO: Foram estudados 97 doentes operados com intenção curativa e seguidos por período mínimo de cinco anos. Excluíram-se doentes que receberam tratamento adjuvante. Os espécimes cirúrgicos foram corados por hematoxilina-eosina e imunoistoquímica para pesquisa da proteína S-100, com o intuito de se comparar a fidedignidade das técnicas em detectar invasão neural, sendo analisadas comparativamente: acurácia, especificidade, sensibilidade e valores preditivos positivo e negativo. A comparação entre a incidência de invasão neural com relação à recidiva foi realizada, empregando-se o teste do qui-quadrado. A sobrevida e sobrevida livre de doença foram estudadas por análise univariada,. Estabeleceu-se nível de significância de 5% (p £ 0,05 para todos os testes adotados. RESULTADOS: A técnica da HE apresentou fraca habilidade em detectar a invasão neural, não sendo adequada para esta análise em doentes portadores de câncer colorretal. As curvas de sobrevida e sobrevida livre de doença dos enfermos portadores de invasão neural, pesquisada por meio da imunocoloração para proteína S-100 são significativamente piores, identificando aquela característica histológica como valor prognóstico independente (p = 0,0003 e p = 0,0002, respectivamente. A ocorrência de recidiva tumoral foi significativamente maior nos doentes que apresentavam invasão neural (p = 0,0010. CONCLUSÃO: Os resultados do presente estudo permitem concluir que, nos doentes portadores de câncer colorretal, a detecção da invasão neural pela pesquisa imunoistoquímica da proteína S-100 demonstrou ser variável independente, acrescentando informa

  13. Valores na escola

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    Menin Maria Suzana De Stefano

    2002-01-01

    Full Text Available Neste texto pretende-se discorrer sobre valores morais na escola e suas implicações para a formação de professores. Para tanto discutir-se-á, em primeiro lugar, e brevemente, o que são valores morais, ou éticos, e como a escola pode situar-se em relação a eles. Em seguida, serão relatadas algumas observações a respeito de valores de professores e práticas daí decorrentes. São comentados resultados de pesquisa que ilustram a transmissão de valores de forma doutrinal e a educação moral e cívica tal como realizada na ditadura militar, e, por outro lado, a posição relativista e/ou de laissez-faire que certas escolas podem adotar, metodologicamente, sobre a educação em valores. Finalmente, defender-se-á a idéia de que é necessária uma discussão sobre valores pelos diversos membros da escola e uma opção por uma metodologia para ensiná-los, seja os professores, em sua formação inicial e continuada, seja os alunos. A teoria de desenvolvimento moral de Jean Piaget será apresentada como uma referência possível para a educação em valores. Exemplos de situações escolares de conflito de valores entre direção, pais e alunos são discutidas para ilustrar como uma escola pode adotar um procedimento democrático de educação em valores, que se apresenta como um terceiro caminho possível de educação moral nas escolas, além das posições doutrinárias ou relativistas.

  14. Comparative analysis of dose-volume histograms between 3D conformal and conventional non-conformal radiotherapy planning for prostate cancer; Analise comparativa dos histogramas de dose e volume entre planejamentos tridimensionais conformados e convencionais nao conformados na radioterapia do cancer de prostata

    Energy Technology Data Exchange (ETDEWEB)

    Feitosa, Silvia Moreira; Giordani, Adelmo Jose; Dias, Rodrigo Sousa; Segreto, Helena Regina Comodo; Segreto, Roberto Araujo [Universidade Federal de Sao Paulo (UNIFESP-EPM), Sao Paulo, SP (Brazil)], e-mail: silviamfeitosa@yahoo.com.br

    2009-03-15

    Objective: The present study was aimed at comparing conformal and non-conformal radiotherapy plans designed for patients with prostate cancer, by analyzing radiation doses in target volumes and organs at risk. Materials and methods: Radiotherapy plans for 40 patients with prostate cancer were analyzed. Conformal, conformal isocentric and non-conformal plans utilizing the source-surface distance were simulated for each of the patients for comparison of radiation dose in target volumes and organs at risk. For comparison purposes, dose-volume histograms for target volumes and organs at risk were analyzed. Results: Median doses were significantly lower in the conformal planning, with 25%, 40% and 60% volumes in the rectum and 30% and 60% in the bladder. The median doses were significantly lower in the conformal planning analyzing the right and left coxofemoral joints. Maximum, mean and median doses in the clinical target volume and in the planned target volume were significantly higher in the conformal planning. Conclusion: The present study has demonstrated that the conformal radiotherapy planning for prostate cancer allows the delivery of higher doses to the target volume and lower doses to adjacent healthy tissues. (author)

  15. Vaginal Cancer

    Science.gov (United States)

    Vaginal cancer is a rare type of cancer. It is more common in women 60 and older. You are also more likely to get it if you have had a human ... test can find abnormal cells that may be cancer. Vaginal cancer can often be cured in its ...

  16. Lung Cancer

    Science.gov (United States)

    Lung cancer is one of the most common cancers in the world. It is a leading cause of cancer death in men and women in the United States. Cigarette smoking causes most lung cancers. The more cigarettes you smoke per day and ...

  17. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Talking about Advanced Cancer Coping with Your Feelings Planning for Advanced Cancer Advanced Cancer and Caregivers Questions ... Talking About Advanced Cancer Coping With Your Feelings Planning for Advanced Cancer Advanced Cancer & Caregivers Managing Cancer ...

  18. What Is Thyroid Cancer?

    Science.gov (United States)

    ... Treatment? Thyroid Cancer About Thyroid Cancer What Is Thyroid Cancer? Cancer starts when cells in the body begin ... cell) Medullary Anaplastic (an aggressive undifferentiated tumor) Differentiated thyroid cancers Most thyroid cancers are differentiated cancers. The cells ...

  19. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Bladder Cancer Breast Cancer Colorectal Cancer Kidney (Renal Cell) Cancer Leukemia Liver Lung Cancer Lymphoma Pancreatic Cancer ... grade, which refers to how abnormal the cancer cells look under a microscope. Grade provides clues about ...

  20. Diet and cancer

    Science.gov (United States)

    Fiber and cancer; Cancer and fiber; Nitrates and cancer; Cancer and nitrates ... DIET AND BREAST CANCER The link between nutrition and breast cancer has been well studied. To reduce risk of breast cancer the American ...

  1. Breast Cancer Overview

    Science.gov (United States)

    ... Cancer > Breast Cancer > Breast Cancer: Overview Request Permissions Breast Cancer: Overview Approved by the Cancer.Net Editorial Board , ... bean-shaped organs that help fight infection. About breast cancer Cancer begins when healthy cells in the breast ...

  2. What Is Breast Cancer?

    Science.gov (United States)

    ... Research? Breast Cancer About Breast Cancer What Is Breast Cancer? Breast cancer starts when cells in the breast ... spread, see our section on Cancer Basics . Where breast cancer starts Breast cancers can start from different parts ...

  3. American Institute for Cancer Research

    Science.gov (United States)

    ... About Cancer By Cancer Site What Is Cancer Foods That Fight Cancer Tools You Can Use Cancer Infographics & Multimedia Studying ... About Cancer By Cancer Site What Is Cancer Foods That Fight Cancer Tools You Can Use Cancer Infographics & Multimedia Studying ...

  4. A aposta na filosofia

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    Márcio Suzuki

    2011-12-01

    Full Text Available Para Hume, filosofar é uma atividade semelhante às demais ocupações humanas. A decisão que leva à atividade filosófica é menos resultado de uma argumentação teórica do que fruto de um cálculo prático, que é entendido como uma caça ou um jogo. O objetivo deste trabalho será o de mostrar que no jogo filosófico perde quem joga sério demais. A aposta na filosofia tem que passar pelo bom humor e pela diversão: uma resposta a Pascal?For Hume, philosophy is in itself neither more nor less important than other human activities. On the contrary, it can be explained from its resemblance with game and hunting. If one chooses to dedicate himself to philosophy, his decision is not the consequence of logical reasoning, but depends on practical evaluation, which has something to do with gambling. The following text tries to show that in philosophy, like in other games, the loser will be the one who plays too earnestly. The philosophical game requires good humour and some relaxation: Is this a good answer to Pascal's pari?

  5. O SUBLIME NA MODERNIDADE

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    Martha de Almeida

    2009-03-01

    Full Text Available A obra Uma investigação filosófica sobre a origem de nossas idéias do sublime e dobelo, do sensualista inglês Edmund Burke (1757, data as origens do sublime na Modernidade. Nosublime ocorre é um prazer ligado à dor, um "horror delicioso" que sentimos quando acreditamosque estamos em perigo sem que isso esteja ocorrendo realmente. Em O mundo como Vontade erepresentação Schopenhauer assume as influências que sofreu de Kant no que diz respeito à suainterpretação sobre o belo e o sublime, porém difere dele quanto à natureza dessa impressão. ParaSchopenhauer a experiência estética pressupõe a dissolução da subjetividade num movimento decontemplação das idéias livre do querer imposto pela vontade individual. As idéias deSchopenhauer influenciaram a estética do Nietzsche de O nascimento da tragédia.

  6. A CORPOREIDADE NA ESCOLA

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    Márcio Xavier Bonorino Figueiredo

    2008-07-01

    Full Text Available Com este estudo, visa-se a investigar como a escola tem construído um corporeidade para a submissão dos estudantes ao sistema de dominação vigente. Propõe-se, também, a descobrir a corporeidade expressa nas brincadeiras, jogos e desenhos das crianças. Realizaram-se observações do espaço escolar de uma sala de aula durante um ano letivo, bem como duas entrevistas com cada uma das crianças de uma turma de 1ª série do 1º grau, em uma escola pública de periferia. Constatou-se que a escola, através de uma série de normas, explícitas ou implícitas, vai construindo uma corporeidade baseada no individualismo, na massificação e nos privilégios de uma minoria. A análise das brincadeiras, jogos e desenhos infantis revelou que estes veiculam valores contrários àqueles impostos pela escola. Em vista disso, elaborou-se uma proposta incipiente de trabalho corporal que tenha nas brincadeiras, jogos e desenhos das crianças o seu ponto de partida para uma práxis transformadora.

  7. Mudanças nos relacionamentos com os amigos, cônjuge e família após o diagnóstico de câncer na mulher Cambios en las relaciones con los amigos, conjuge y familia tras el diagnostico de cancer en la mujer Changes in relationships with friends, husband and family after cancer diagnostic in the woman

    Directory of Open Access Journals (Sweden)

    Maria Aparecida Salci Molina

    2006-08-01

    Full Text Available A proposta deste estudo foi identificar mudanças ocorridas nos relacionamentos após o diagnóstico de câncer na mulher. Como estratégia teórico-metodológica foi utilizado respectivamente o Interacionismo Simbólico e a Teoria Fundamentada nos Dados. Fizeram parte da pesquisa 10 mulheres portadoras de câncer e um familiar. Identificamos que ocorreu mudanças nos relacionamentos com amigos, em que as relações que já eram íntimas consolidaram-se ainda mais e as superficiais inexistiram. Com os cônjuges, alguns relacionamentos tornaram-se melhores e outros, que já eram conflituosos, passaram por vários problemas chegando até à separação. Com a família, os relacionamentos tornaram-se mais fortes. O estudo nos permite compreender um contexto particular da mulher com câncer e repensar algumas estratégias de cuidados a partir dessas relações.La propuesta de este estudio fue a de identificar cambios ocurridos en las relaciones, tras el diagnóstico de cáncer en la mujer. Como estrategia teórico-metodológica se utilizó respectivamente el Interacionismo Simbólico y la Teoría Fundamentada en los Datos. Formaron parte de la investigación 10 mujeres portadoras de cáncer y un familiar. Identificamos que ocurrieron cambios en las relaciones con amigos, y que las relaciones que ya eran íntimas se consolidaron todavía más y las superficiales no siguieron adelante. Con los cónyuges, algunas relaciones mejoraron y otras, que ya eran conflictivas, pasaron por varios problemas llegando hasta a la separación. Con la familia, las relaciones se fortalecieron aún más. El estudio nos permite comprender un contexto particular de la mujer con cáncer y repensar algunas estrategias de cuidados a partir de esas relaciones.The proposal of this research was to identify changes occurred in relationships after cancer diagnosis in the womam. As a theoretical-methodological strategy it was utilized respectively the Symbolic Interacionism and

  8. O cuidado do paciente oncológico com dor crônica na ótica do enfermeiro El cuidado del paciente oncológico con dolor crónico en la visión del enfermero The care to cancer patients with chronic pain in the view of nurses

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    Lili Marlene Hofstätter da Silva

    2001-01-01

    Full Text Available O objetivo deste estudo foi identificar como o enfermeiro interpreta o cuidado com o paciente oncológico com dor crônica. O estudo foi desenvolvido com oito enfermeiros de uma instituição hospitalar. Os dados foram coletados por entrevistas semi-estruturadas e na análise identificamos três categorias analíticas: a avaliação da dor crônica do paciente oncológico, a importância do cuidado multidisciplinar e as dificuldades para o cuidado do paciente. Os resultados mostram que os enfermeiros têm dificuldades em desenvolver o cuidado com o paciente devido à falta de conhecimentos específicos sobre o câncer, dor crônica e sua terapêutica, como também, nas habilidades expressivas para promoverem o apoio psicológico adequado.El objetivo de este estudio fue identificar como el enfermero interpreta el cuidado para el paciente oncológico con dolor crónico. El estudio fue desarrollado con ocho enfermeros de una institución hospitalaria. Los datos fueron recolectados por entrevistas semi-estructuradas y en el análisis identificamos tres categorías analíticas: la evaluación del dolor crónico del paciente oncológico, la importancia del cuidado multidisciplinario y las dificultades para el cuidado del paciente. Los resultados muestran que los enfermeros tienen dificultades para desarrollar el cuidado con el paciente debido a la falta de conocimientos específicos con respecto al cáncer, dolor crónico y su tratamiento, como también, en las habilidades expresivas para la promoción del apoyo psicológico adecuado.This study aims to understand how nurses interpret the care given to cancer patients with chronic pain. The informers were eight nurses from a public hospital. Data were collected on the basis of semi-structured interviews and the analysis identified three analytical categories: the evaluation of patients' pain, the importance of multidisciplinary care and nurses' difficulties to care for these patients. The results show

  9. Cancer Screening

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    Krishna Prasad

    2004-10-01

    Full Text Available Cancer screening is a means to detect cancer early with the goal of decreasing morbidity and mortality. At present, there is a reasonable consensus regarding screening for breast, cervical and colorectal cances and the role of screening is under trial in case of cancers of the lung,  ovaries and prostate. On the other hand, good screening tests are not available for some of the commonest cancers in India like the oral, pharyngeal, esophageal and stomach cancers.

  10. Um toque na masculinidade: a prevenção do câncer de próstata em gaúchos tradicionalistas Un toque a la masculinidad: la prevención del cáncer de próstata en gauchos tradicionalistas A touch on masculinity: prostate cancer prevention in traditionalist Gauchos

    Directory of Open Access Journals (Sweden)

    Luccas Melo de Souza

    2011-03-01

    Full Text Available Estudo transversal, com abordagem quantitativa, realizado com 88 gaúchos tradicionalistas participantes do Acampamento Farroupilha de 2009. Objetivou-se verificar a adesão desses gaúchos tradicionalistas aos exames preventivos de câncer de próstata, analisando, também, quais variáveis influenciam na adesão ao exame de toque retal. Os entrevistados possuíam média de idade de 58,5 anos, com alto salário e elevada escolaridade. Grande parte (92% residiu maior tempo em zona urbana, fazia acompanhamento de saúde em instituição particular (70,5% e realizou algum exame preventivo para o câncer de próstata (83%. Os que fizeram exame preventivo possuíam maior escolaridade, renda e consultavam em instituição particular. Houve menor procura aos exames preventivos por aqueles que moraram a maior parte da sua vida em zona rural. Contudo, não houve relação do local onde residiu o maior tempo com a adesão ao exame de toque retal. Os achados indicam semelhança na adesão aos exames preventivos a outros estudos realizados no Brasil.Este estudio transversal y cuantitativo fue realizado con 88 gauchos tradicionalistas que participaron del Campamento Farroupilha en 2009. Se verificó la adhesión de los participantes a los exámenes preventivos del cáncer de próstata, analizando, también, cuales variables influyen en la adhesión al examen de tacto rectal. Los encuestados tenían edad media de 58,5 años, con altos salarios y nivel de escolaridad. Gran parte (92% había residido mayor tiempo en las zonas urbanas, hacía acompañamiento de salud en instituciones privadas (70,5% e hizo algún examen preventivo de cáncer de próstata (83%. Los que han realizado examen preventivo tenían mayor nivel de escolaridad, renta y atención de salud en institución privada. Hubo menos demanda de exámenes preventivos por los que habían vivido más tiempo en la zona rural. Sin embargo, no hubo relación entre el lugar de residencia y la adhesión al

  11. Ulogata na endoetelin-1 vo razvojot na dijabeticna nefropatija inducirana so streptozocin

    Directory of Open Access Journals (Sweden)

    Jasmina Trojacanec

    2006-06-01

    Full Text Available Dijabeticnata nefropatija pretstavuva edna od hronicnite mikrovaskularni komplikacii na dijabetot, so multifaktorijalna i ne do kraj rasvetlena etiopatogeneza. So ogled na toa sto kaj pacientite so dijabet, osobeno kaj onie so dijabeticna nefropatija, se najdeni zgolemeni vrednosti na endotelin-1, se pretpostavuva deka istiot moze da ima znacajna uloga vo razvojot na dijabeticnata nefropatija. Osnovna cel na nasata studija bese da se detektiraat promenite vo plazmatskoto nivo na endotelin-1 po eksperimentalno induciran dijabet, i dijabeticna nefropatija kaj staorci so streptozocin. So ogled na dobro poznatite efekti na AKE-inhibitorite, vo ovaa studija go ispituvavme i vlijanieto na enalapril (AKE inhibitor na plazmatskite koncentracii na endotelin-1, kako i negovite efekti vo tretmanot na dijabeti~na nefropatija. Ednokratnata i.p. administracija na streptozocin (STZ predizvika signifikantno zgolemuvanje na plazmatskite koncentracii na endotelin-1, proprateni so jasno izrazeni simptomi i znaci na dijabeticna nefropatija (mikroalbuminurija, zgolemeni urinarni vrednosti na N-acetyl-fl-D-glucosamidase, zgolemeni serumski koncentracii na urea, poliurija. Cetiri nedelniot tretman so enalapril dovede do signifikantno namaluvanje na plazmatskite koncentracii na endotelin-1 i do podobruvanje na simtomite i znacite na dijabeticnata nefropatija. Dobienite rezultati potvrduvaat deka endotelin-1 moze da ima znacajna uloga vo razvojot i progresijata na dijabeticnata nefropatija, a AKE inhibitorite, odnosno enalapril, mozat da ja ublazat i usporat progresijata na dijabeticnata nefropatija

  12. Correlation between clinical examination, mammography and ultrasonography with histopathological exam in the determination of tumor size in breast cancer; Correlacao entre o exame clinico, a mamografia e a ultra-sonografia com o exame anatomopatologico na determinacao do tamanho tumoral no cancer de mama

    Energy Technology Data Exchange (ETDEWEB)

    Siqueira, Fernanda Monteiro de Paula; Rezende, Cezar Alencar de Lima [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Faculdade de Medicina. Dept. de Ginecologia e Obstetricia]. E-mail: fersiqueira75@yahoo.com.br; Barra, Alexandre de Almeida [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Hospital das Clinicas. Servico de Diagnostico por Imagem

    2008-07-01

    Purpose: to evaluate which method is the best to determine pre-surgically the size of breast cancer: clinical examination, mammography or ultrasonography, using as a reference the anatomopathological exam. Methods: this study has included 184 patients with palpable-or-not breast lesions, detected by mammography and ultrasonography, that were submitted to surgical resection of the tumor, with histopathological diagnosis of breast cancer. The same examiner evaluated clinically the largest tumoral diameter, through clinical examination, mammography and ultrasonography, and the measurements obtained by each method were correlated with the maximum diameter obtained by the anatomopathological exam. The comparative analysis has been done by Pearson's correlation coefficient (r). Results: Pearson's correlation coefficient between the anatomopathological and the clinical exams was 0.8; between the anatomopathological exam and the mammography, 0.7; and between anatomopathological exam and ultrasonography 0.7 (p<0.05). Pearson's correlation coefficients among the methods evaluated were also calculated and r=0.7 was obtained between clinical exam and mammography, r=0.8 between clinical examination and ultrasonography, and r=0.8 between mammography and ultrasonography (p<0.05). Conclusions: clinical examination, mammography and ultrasonography have presented high correlation with the anatomopathological measures, besides high correlations among themselves, what seems to show that they may be used as equivalent methods in the pre-surgical evaluation of the breast tumoral size. Nevertheless, due to specific limitations of each method, clinical examination, mammography and ultrasonography should be seen as complementary to each other, in order to obtain a more accurate measurement of the breast cancer tumor.(author)

  13. SPOLNO NADLEGOVANJE NA DELOVNEM MESTU

    OpenAIRE

    Rubič, Gašper

    2016-01-01

    V diplomskem delu smo v uvodu predstavili problem spolnega nadlegovanja na delovnem mestu in predstavili podjetje TEKSTIL d.d. V nadaljevanju smo z anketo raziskali, ali problem spolnega nadlegovanja na delovnem mestu v obravnavanem podjetju obstaja in če, kako se nanj odziva okolje. V teoretičnem delu smo nadaljevali in predstavili definicijo spolnega nadlegovanja, ki je kakršna koli oblika nezaželenega verbalnega in neverbalnega ali fizičnega ravnanja spolne narave z učinkom ali nameno...

  14. Dificuldades da aprendizagem na leitura

    OpenAIRE

    Nascimento, Solange Oliveira; Trugillo, Edneuza Alves

    2011-01-01

    Este presente artigo propôs verificar os fatores que influenciam no desenvolvimento da aprendizagem na leitura dos alunos da 4º ano no Ensino Fundamental na Escola Municipal Armando Dias no município de Sinop/MT, cujo tema é dificuldade da aprendizagem na leitura. O objetivo do trabalho foi investigar as relações interpessoais em sala de aula e de que forma a professora introduz a leitura nos conteúdos dados aos alunos. Como fundamentação teórica, recorremos a vários autores, entre eles: Enri...

  15. The role of 18F–NaF PET/CT in metastatic bone disease

    Directory of Open Access Journals (Sweden)

    Mine Araz

    2015-09-01

    Conclusion: Although further prospective clinical studies in specific cancer populations are indicated to set the place of 18F–NaF PET/CT in diagnostic scheme, the results of this pilot study from our country support the superiority of 18F–NaF PET/CT in investigation of bone metastasis over 99mTc-MDP bone scan and 18F-FDG PET/CT in various malignancies. 18F–NaF PET/CT is coming forward as a single step bone seeking study, considering all the advantages, but especially potential of detecting occult metastases and reliably directing patient management.

  16. Cancer Research Repository for Individuals With Cancer Diagnosis, High Risk Individuals, and Individuals With No History of Cancer (Control)

    Science.gov (United States)

    2016-11-14

    Pancreatic Cancer; Thyroid Cancer; Lung Cancer; Esophageal Cancer; Thymus Cancer; Colon Cancer; Rectal Cancer; GIST; Anal Cancer; Bile Duct Cancer; Duodenal Cancer; Gallbladder Cancer; Gastric Cancer; Liver Cancer; Small Intestine Cancer; Peritoneal Surface Malignancies; Familial Adenomatous Polyposis; Lynch Syndrome; Bladder Cancer; Kidney Cancer; Penile Cancer; Prostate Cancer; Testicular Cancer; Ureter Cancer; Urethral Cancer; Hypopharyngeal Cancer; Laryngeal Cancer; Lip Cancer; Oral Cavity Cancer; Nasopharyngeal Cancer; Oropharyngeal Cancer; Paranasal Sinus Cancer; Nasal Cavity Cancer; Salivary Gland Cancer; Skin Cancer; CNS Tumor; CNS Cancer; Mesothelioma; Breastcancer; Leukemia; Melanoma; Sarcoma; Unknown Primary Tumor; Multiple Myeloma; Ovarian Cancer; Endometrial Cancer; Vaginal Cancer

  17. Studies on NaXe Clusters

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The chemical shift of 23Na in excimer NaXe was measured by using nuclear magnetic resonance (NMR) spectra, which is in good agreement with the theoretical value obtained by ab initio calculations. The bond length, dissociation energy, dipole of NaXe and Mulliken charges at Na and Xe in NaXe were calculated, respectively. The spectra of ultraviolet (UV) fluorescence and surface-enhanced Raman scattering of NaXe were also measured.

  18. Análise comparativa dos histogramas de dose e volume entre planejamentos tridimensionais conformados e convencionais não conformados na radioterapia do câncer de próstata Comparative analysis of dose-volume histograms between 3D conformal and conventional non-conformal radiotherapy plannings for prostate cancer

    Directory of Open Access Journals (Sweden)

    Sílvia Moreira Feitosa

    2009-04-01

    Full Text Available OBJETIVO: Analisar, comparativamente, doses de radiação em volumes alvos e órgãos de risco entre planejamentos conformados e não conformados em pacientes com câncer de próstata. MATERIAIS E MÉTODOS: No presente trabalho foram analisados planejamentos de 40 pacientes portadores de câncer de próstata. Foram realizados planejamentos conformados, não conformados isocêntricos e não conformados utilizando a distância fonte-superfície, simulados para cada caso, para comparação das doses em volumes alvos e órgãos de risco. Para a comparação foram analisados os histogramas de dose e volume para volumes alvos e órgãos de risco. RESULTADOS: As medianas das doses foram significativamente menores no planejamento conformado analisando-se os seguintes volumes no reto: 25%, 40% e 60%. As medianas das doses foram significativamente menores no planejamento conformado analisando-se os seguintes volumes na bexiga: 30% e 60%. As doses medianas foram significativamente menores no planejamento conformado analisando-se as articulações coxofemorais direita e esquerda. As doses máximas, médias e medianas no volume alvo clínico e no volume alvo planejado foram significativamente maiores no planejamento conformado. CONCLUSÃO: O presente estudo demonstrou que por meio do planejamento conformado em pacientes com câncer de próstata é possível entregar doses maiores no volume alvo e doses menores em órgãos de risco.OBJECTIVE: The present study was aimed at comparing conformal and non-conformal radiotherapy plans designed for patients with prostate cancer, by analyzing radiation doses in target volumes and organs at risk. MATERIALS AND METHODS: Radiotherapy plans for 40 patients with prostate cancer were analyzed. Conformal, conformal isocentric and non-conformal plans utilizing the source-surface distance were simulated for each of the patients for comparison of radiation dose in target volumes and organs at risk. For comparison purposes

  19. Na via do Behemoth

    Directory of Open Access Journals (Sweden)

    Gérard Rabinovitch

    2008-06-01

    Full Text Available O momento nazista permanece um enigma impensado de que a cultura contemporânea continua cativa. O autor levanta a hipótese de que a persistência desse enigma e seus estragos duráveis se devem à insistência dos pensamentos político, sociológico e filosófico em construírem o nazismo à luz da metáfora hobbesiana do Leviatã. Propõe retomar a questão do nazismo sob a perspectiva do Behemoth, antônimo do Leviatã. Para tanto, sugere a necessidade de retornar a Freud e à psicanálise, balizas de um possível novo pensamento do político que escrutine a destrutividade nazista. Propõe ainda sondar as homologias entre nazismo, corjas e máfias, com base na figura da " heroicização da violência" que lhes seria comum. E avança um modelo " econômico" : a quimera, suscetível de capturar o caráter heterotópico e heterocrônico de sua construção criminosa.The paths of Behemoth. The Nazi moment remains as the thoughtless enigma of which contemporary culture is still captive. The author raises the hypothesis where the persistency of this enigma and its durable damages are due to the insistence of the political, social and philosophical thoughts in building the Nazism at the view of the Hobbesian metaphor of Leviathan. It is here proposed to resume the Nazism matter under Behemoth's perspective, antonym to Leviathan. For such, it is suggested a necessity to look back at Freud and the psychoanalysis, structured by a possible new political thought which scrutinizes the destructivity of the Nazism. It is also here proposed to gaze at the homologies between Nazism, mafias and gangs, with a base in the figure of " violence as a heroically act" that are their common ground. The author also advances an economical model: the chimera susceptible to capture the heterotopic and heterochronic character of its criminal construction.

  20. Results from NA61/SHINE

    Directory of Open Access Journals (Sweden)

    Unger M.

    2013-06-01

    Full Text Available In this paper we summarize recent results from NA61/SHINE relevant for heavy ion physics, neutrino oscillations and the interpretation of air showers induced by ultra-high energy cosmic rays.

  1. Characterizing and Targeting Replication Stress Response Defects in Breast Cancer

    Science.gov (United States)

    2015-08-01

    N/A 4 INTRODUCTION In both precancerous breast lesions and breast cancer, hyperproliferative activity due to...RSR defects distinguishes premalignant lesions and breast cancer from normal tissues, which makes these defects effective targets for both breast... oral gavage. i.p., intraperitoneal injection. N = 8. ! ! 8 ! ! ! ! ! !! ! Table 1. The summary of tumorigenesis assay in MDA-MB-231 xenograft model

  2. Risbjerg: Historisk stemmeskred med NA

    DEFF Research Database (Denmark)

    Thomsen, Søren Risbjerg

    2007-01-01

    ANALYSE: NA flytter 12,3 pct. af stemmerne i majs meningsmålinger - historisk mange vælgere på en måned, skriver professor Risbjerg. Udgivelsesdato: 3. juni 2007......ANALYSE: NA flytter 12,3 pct. af stemmerne i majs meningsmålinger - historisk mange vælgere på en måned, skriver professor Risbjerg. Udgivelsesdato: 3. juni 2007...

  3. Cervical Cancer

    Science.gov (United States)

    ... the place where a baby grows during pregnancy. Cervical cancer is caused by a virus called HPV. The ... for a long time, or have HIV infection. Cervical cancer may not cause any symptoms at first. Later, ...

  4. Oral cancer

    Science.gov (United States)

    ... Some oral cancers begin as a white plaque ( leukoplakia ) or as a mouth ulcer . Men develop oral ... use and safe drinking Cancer Dental care - adult Leukoplakia Metastasis Mouth ulcers Patient Instructions Dry mouth during ...

  5. Cancer Clusters

    Science.gov (United States)

    ... type Progress Annual Report to the Nation Cancer Portfolio Snapshots Milestones in Cancer Research & Discovery Stories of ... Institute for Occupational Safety and Health (NIOSH) Hazard Evaluation and Technical Assistance Branch Health Hazard Evaluation (HHE) ...

  6. Endometrial cancer

    Science.gov (United States)

    ... to be at a higher risk of endometrial cancer: Colon or breast cancer Diabetes Gallbladder disease High blood ... laparoscopic - discharge Hysterectomy - vaginal - discharge Pelvic radiation - discharge Review Date 4/5/2016 Updated by: Irina Burd, ...

  7. Cancer prevention

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Introduction A 44 year old woman attends your surgery,distressed by the fact that her closest friend has just been given a diagnosis of colorectal cancer. She wants to know how to minimise her risk of developing cancer.

  8. Eye Cancer

    Science.gov (United States)

    Cancer of the eye is uncommon. It can affect the outer parts of the eye, such as the eyelid, which are made up ... adults are melanoma and lymphoma. The most common eye cancer in children is retinoblastoma, which starts in ...

  9. Nasal Cancer

    Science.gov (United States)

    ... the way to your throat as you breathe. Cancer of the nasal cavity and paranasal sinuses is ... be like those of infections. Doctors diagnose nasal cancer with imaging tests, lighted tube-like instruments that ...

  10. Gallbladder Cancer

    Science.gov (United States)

    ... your gallbladder and liver to your small intestine. Cancer of the gallbladder is rare. It is more ... the abdomen It is hard to diagnose gallbladder cancer in its early stages. Sometimes doctors find it ...

  11. Colorectal Cancer

    Science.gov (United States)

    ... rectum are part of the large intestine. Colorectal cancer occurs when tumors form in the lining of ... men and women. The risk of developing colorectal cancer rises after age 50. You're also more ...

  12. Pancreatic Cancer

    Science.gov (United States)

    ... hormones that help control blood sugar levels. Pancreatic cancer usually begins in the cells that produce the juices. Some risk factors for developing pancreatic cancer include Smoking Long-term diabetes Chronic pancreatitis Certain ...

  13. Cancer Disparities

    Science.gov (United States)

    Basic information about cancer disparities in the U.S., factors that contribute to the disproportionate burden of cancer in some groups, and examples of disparities in incidence and mortality among certain populations.

  14. Prostate Cancer

    Science.gov (United States)

    ... man's bladder that produces fluid for semen. Prostate cancer is common among older men. It is rare ... younger than 40. Risk factors for developing prostate cancer include being over 65 years of age, family ...

  15. Thymus Cancer

    Science.gov (United States)

    ... cell. These cells help protect you from infections. Cancer of the thymus is rare. You are more ... Sometimes there are no symptoms. Other times, thymus cancer can cause A cough that doesn't go ...

  16. Intestinal Cancer

    Science.gov (United States)

    ... connects your stomach to your large intestine. Intestinal cancer is rare, but eating a high-fat diet ... increase your risk. Possible signs of small intestine cancer include Abdominal pain Weight loss for no reason ...

  17. Esophageal Cancer

    Science.gov (United States)

    ... from your throat to your stomach. Early esophageal cancer usually does not cause symptoms. Later, you may ... You're at greater risk for getting esophageal cancer if you smoke, drink heavily, or have acid ...

  18. Influence of CaNa2 EDTA on topical 5-aminolaevulinic acid photodynamic therapy

    Institute of Scientific and Technical Information of China (English)

    刘辉峰; 徐世正; 张春荣

    2004-01-01

    Background We asssessed whether the CaNa2 EDTA could improve the accumulation of protoporphyrin Ⅸ (PpⅨ) and photosensitisation in HEp-2 cells as well as the depth of treatment of skin cancers on the topical 5-Aminolaevulinic acid (5-ALA) PDT.Methods HEp-2 cells were incubated with 5-ALA (0-1mmol/L) and CaNa2EDTA (0-1mmol/L) for 4 hours, intracellular protoporphyrin Ⅸ content was quantified by extraction, and cell viability was assessed by use of the methyl-tetrazolium (MTT) assay four hours after exposure to light. In comparison with the pictures before and after treatment, depth of treatment could be determined using a Acuson Sequioa 512 phase-array system in paired experiments.Results PpⅨ accumulation increased with increasing extracellular concentrations of ALA (0-1mmol/L). Adding 1mmol/L of CaNa2EDTA increased 30% PpⅨ accumulation over the same period of incubation in the concentration of 1mmol/L ALA. Significant difference was observed between the 5-ALA alone group and 5-ALA combined CaNa2 EDTA group in the PpⅨ accumulation (P<0.01). Cell viability after exposure to light decreased with adding CaNa2 EDTA, a statistical difference in a same fluence above 1.2 J/cm2 between two groups was demonstrated (P<0.05, P<0.01 respectively). Depth of treatment of skin cancers were increased in CaNa2 EDTA-treated group.conclusion CaNa2 EDTA could improve the PpⅨ accumulation and photosensitisation in HEp-2 cells. Clinically, CaNa2 EDTA could increase the depth of treatment in the cutaneous cancers.

  19. Thyroid Cancer Risk Factors

    Science.gov (United States)

    ... Prevented? Thyroid Cancer Causes, Risk Factors, and Prevention Thyroid Cancer Risk Factors A risk factor is anything that ... Cancer? Can Thyroid Cancer Be Prevented? More In Thyroid Cancer About Thyroid Cancer Causes, Risk Factors, and Prevention ...

  20. Lung Cancer Prevention

    Science.gov (United States)

    ... Treatment Lung Cancer Prevention Lung Cancer Screening Research Lung Cancer Prevention (PDQ®)–Patient Version What is prevention? Go ... to keep cancer from starting. General Information About Lung Cancer Key Points Lung cancer is a disease in ...

  1. Surgery for Breast Cancer

    Science.gov (United States)

    ... Cancer During Pregnancy Breast Cancer Breast Cancer Treatment Surgery for Breast Cancer Surgery is a common treatment ... removed (breast reconstruction) Relieve symptoms of advanced cancer Surgery to remove breast cancer There are two main ...

  2. Skin Cancer Prevention

    Science.gov (United States)

    ... Genetics of Skin Cancer Skin Cancer Screening Research Skin Cancer Prevention (PDQ®)–Patient Version What is prevention? ... prevent cancer are being studied. General Information About Skin Cancer Key Points Skin cancer is a disease ...

  3. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Effects of Childhood Cancer Treatment Pediatric Supportive Care Unusual Cancers of Childhood Treatment Childhood Cancer Genomics Study ... Genomics Causes of Cancer Diagnosis Prevention Screening & Early Detection Treatment Cancer & Public Health Cancer Health Disparities Childhood ...

  4. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Partners & Collaborators Spotlight on Scientists Research Areas Cancer Biology Cancer Genomics Causes of Cancer Diagnosis Prevention Screening & ... Collaborators Spotlight on Scientists NCI Research Areas Cancer Biology Cancer Genomics Causes of Cancer Diagnosis Prevention Screening & ...

  5. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Cancers Metastatic Cancer Recurrent Cancer Research NCI’s Role in Cancer Research Intramural Research Extramural Research Bioinformatics and ... Annual Report to the Nation Cancer Snapshots Milestones in Cancer Research and Discovery Stories of Discovery R& ...

  6. Targeted therapies for cancer

    Science.gov (United States)

    ... types of these cancers: Leukemia and lymphoma Breast cancer Colon cancer Skin cancer Lung cancer Prostate Other cancers ... ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 44. Review Date 9/13/2015 Updated by: Todd Gersten, ...

  7. Throat or larynx cancer

    Science.gov (United States)

    Vocal cord cancer; Throat cancer; Laryngeal cancer; Cancer of the glottis; Cancer of oropharynx or hypopharynx ... use tobacco are at risk of developing throat cancer. Drinking too much alcohol over a long time ...

  8. Surgery for Testicular Cancer

    Science.gov (United States)

    ... Stage Testicular Cancer Treating Testicular Cancer Surgery for Testicular Cancer Surgery is typically the first treatment for all ... Testicular Cancer, by Type and Stage More In Testicular Cancer About Testicular Cancer Causes, Risk Factors, and Prevention ...

  9. What Is Testicular Cancer?

    Science.gov (United States)

    ... Treatment? Testicular Cancer About Testicular Cancer What Is Testicular Cancer? Cancer starts when cells in the body begin ... respond well to chemotherapy and radiation therapy. Secondary testicular cancers Cancers that start in another organ and then ...

  10. Prostate Cancer

    OpenAIRE

    Eggener, Scott

    2011-01-01

    Prostate cancer continues to be a significant public health issue worldwide, particularly in countries where men have life expectancies long enough to clinically manifest the disease. In many countries, it remains one of the leading causes of cancer-related morbidity and mortality.Although significant progress has been made over the past few decades, many elements regarding the diagnosis and management of patients with prostate cancer remain enigmatic. In this Prostate Cancer special issue, o...

  11. Prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, G.P.; Kuss, R., Khoury, S.; Chatelain, C.; Denis, L.

    1987-01-01

    This book contains over 70 selections. Some of the titles are: Place of the Computed Tomography in the Staging of Prostatic Cancer; Magnetic Resonance Imaging (MRI) in Staging of the Prostatic Cancer; Magnetic Resonance Imaging of the Prostate; Long-Term Results in Radiotherapy of Prostatic Cancer; Interstitial Irradiation Using I-125 Seeds; and Treatment of Cancer of the Prostate by Use of Physiotherapy: Long-Term Results.

  12. Profiling cancer

    DEFF Research Database (Denmark)

    Ciro, Marco; Bracken, Adrian P; Helin, Kristian

    2003-01-01

    In the past couple of years, several very exciting studies have demonstrated the enormous power of gene-expression profiling for cancer classification and prediction of patient survival. In addition to promising a more accurate classification of cancer and therefore better treatment of patients......, gene-expression profiling can result in the identification of novel potential targets for cancer therapy and a better understanding of the molecular mechanisms leading to cancer....

  13. Breast cancer

    CERN Multimedia

    2002-01-01

    "Cancer specialists will soon be able to compare mammograms with computerized images of breast cancer from across Europe, in a bid to improve diagnosis and treatment....The new project, known as MammoGrid, brings together computer and medical imaging experts, cancer specialists, radiologists and epidemiologists from Bristol, Oxford, Cambridge, France and Italy" (1 page).

  14. Cancer Vaccines

    Science.gov (United States)

    ... Cervical Cancer Solid Tumors Selected References Pardoll D. Cancer immunology. In: Abeloff M, Armitage J, Niederhuber J, Kastan ... 178(4):1975–1979. [PubMed Abstract] Finn OJ. Cancer immunology. New England Journal of Medicine 2008;358(25): ...

  15. Testicular Cancer

    Science.gov (United States)

    ... of skin behind the penis. You can get cancer in one or both testicles. Testicular cancer mainly affects young men between the ages of ... undescended testicle Have a family history of the cancer Symptoms include pain, swelling, or lumps in your ...

  16. Breast Cancer

    Science.gov (United States)

    Breast cancer affects one in eight women during their lives. No one knows why some women get breast cancer, but there are many risk factors. Risks that ... who have family members with breast or ovarian cancer may wish to be tested for the genes. ...

  17. Dificuldades da aprendizagem na leitura

    Directory of Open Access Journals (Sweden)

    Solange Oliveira Nascimento

    2011-07-01

    Full Text Available Este presente artigo propôs verificar os fatores que influenciam no desenvolvimento da aprendizagem na leitura dos alunos da 4º ano no Ensino Fundamental na Escola Municipal Armando Dias no município de Sinop/MT, cujo tema é dificuldade da aprendizagem na leitura. O objetivo do trabalho foi investigar as relações interpessoais em sala de aula e de que forma a professora introduz a leitura nos conteúdos dados aos alunos. Como fundamentação teórica, recorremos a vários autores, entre eles: Enrique Cártula Fita, Elisabete da Assunção Jóse, Jésus Alonso Tapia, Maria Tereza Coelho e Ruth Caribe da Rocha Drouet. A metodologia usada consistiu na pesquisa qualitativa, no estudo de caso e questionário com perguntas abertas e fechadas aplicadas à professora e três alunos que estão com dificuldades na leitura. Através dos relatos dos sujeitos realizamos um estudo analítico confrontando os dados da pesquisa com os autores principais que fundamentam a mesma. O presente trabalho pretende contribuir e mostrar ao professor em sala de aula a importância de incentivar os alunos a aprenderem a ler com prazer motivando-os a despertar o interesse e gosto pela leitura. Os resultados da investigação revelam que a professora pesquisada está ciente de seu papel e procura meios para enfrentar os problemas existentes em sala de aula, em especial às dificuldades da aprendizagem na leitura e os alunos percebem a importância da leitura e tem vontade em avançar nesse aprendizado.Palavras-chave: educação; dificuldades na aprendizagem. professor; aluno; sala de aula.

  18. Overexpression of metallothioneins, stem cell niches and field cancerization in experimental gliomagenesis Superexpresión de metalotioneínas, nichos de células madre y campos de cancerización en gliomagénesis experimental A superexpressão de metalotioneínas em células-tronco de áreas cancerígenas na gênese de glioma experimental

    Directory of Open Access Journals (Sweden)

    Julio César Fernandes da Silva

    2009-12-01

    Full Text Available INTRODUCTION: stem cells may originate and perpetuate the tumor growth, but they are poorly known in gliomagenesis. Metallothioneins (MTs are proteins involved in oncogenesis and immunopositivity, for MT may be used as a stem cell mutation marker. OBJECTIVE: to study the MT expression in the ENU experimental model and to establish an experimental model to track glioma stem cells in early oncogenesis. METHODS: Thirty-six male Wistar rats were divided into two groups; the experimental group was treated within 24 hours after birth (neonate rats with a single dose of subcutaneously injected N-ethyl N-nitrosourea ENU (40 mg/kg body weight. The control animals were injected with the same volume of saline. These experimental animals were subdivided into three groups according to the euthanize time, as follows: the Group 1 (G1 was euthanized at the age of 30 days; the Group 2 (G2, at the age of 180 days and the Group 3 (G3 was euthanized soon after the appearing of signs of the existence of nervous system tumors, at an average age of 321 days. Immunohistochemical detection of MT protein in cold acetone-fixed paraffin embedded spine cord sections was performed by the streptavidin-avidin-biotin-immuno peroxidase complex method. RESULTS: by using the experimental model of gliomagenesis induced by the N-ethyl N-nitrosourea, it was possible to detect putative tumor stem cells in early oncogenesis, to analyze a field cancerization process and to observe a close morphological relationship between MT positive cells and blood vessels. CONCLUSIONS: this reproducible experimental model allows further studies on the origins, development and regulating factors involved in gliomagenesis.INTRODUCCIÓN: células madre pueden originar y perpetuar el crecimiento tumoral, sin embargo son poco conocidas en la gliomagénesis. Las metalotioneínas (MTs son proteínas involucradas en la oncogénesis, y la inmunopositividad de las MTs puede ser utilizada como marcador de

  19. Diferença entre hospitais privado e universitário na taxa de linfonodos de peça cirúrgica de câncer colorretal: o papel do patologista Difference between university and private hospitals on lymph nodes harvest of surgical colorectal cancer specimens: the role of the pathologist

    Directory of Open Access Journals (Sweden)

    Rodrigo Gomes da Silva

    2010-03-01

    Full Text Available Tem sido demonstrado que o número de linfonodos obtidos em peças cirúrgicas de câncer colorretal é fundamental para o adequado estadiamento da doença e, consequentemente, para a obtenção de melhores resultados oncológicos. A percepção de diferenças no número de linfonodos dissecados em peças cirúrgicas de câncer colorretal pelos mesmos cirurgiões em hospitais diferentes motivou este estudo. O objetivo do presente estudo foi avaliar se há diferença no número de linfonodos e em determinados parâmetros histopatológicos em peça cirúrgica de pacientes com câncer colorretal operados por dois cirurgiões que atuam tanto em hospital universitário, como em hospital privado. MÉTODO: Foram avaliados retrospectivamente 122 pacientes, obtendo-se dados relativos a tipo de instituição (universitária versus privada, aspectos demográficos, estadiamento, localização do tumor, tipo de operação, via de acesso (aberta versus laparoscópica , indicação de radioterapia, número de linfonodos dissecados, número de linfonodos positivos e negativos, assim como o tipo histológico, presença de invasões vascular, linfática e perineural e resposta linfocítica. RESULTADOS: Sessenta e cinco pacientes foram operados em instituição universitária e 57, em instituição privada. Não houve diferença entre os grupos quanto à idade, gênero, estadiamento, localização do tumor, indicação de radioterapia e tipo de operação. A via laparoscópica foi mais comum na instituição universitária. A mediana de linfonodos dissecados foi de 25 (P25-75: 15-34 na instituição universitária versus 15 (P25-75;12-17 (pIt has been demonstrated that lymph nodes harvest from surgical specimens of colorectal cancer is one of the most important features for appropriate staging of the disease and to plain the best treatment. The perception of differences in the number of harvest lymph nodes in surgical specimens of colorectal cancer by the same

  20. 6 Common Cancers - Colorectal Cancer

    Science.gov (United States)

    ... consisted of treatment with just two drugs, 5-fluorouracil (5-FU) and leucovorin. A third drug, irinotecan, was approved ... FDA in 1996 for use in combination with 5-FU and leucovorin in treating metastatic colorectal cancer (cancer ...

  1. Na Deposition on MnO(100)

    Science.gov (United States)

    Feng, Xu; Cox, David F.

    2016-03-01

    Na deposition on the MnO(100) surface was investigated by temperature programmed desorption (TPD), X-ray photoelectron spectroscopy (XPS) and low energy electron diffraction (LEED). Na TPD and XPS results indicate that adsorbed Na interacts strongly with the MnO substrate to form an irreversibly-adsorbed, oxidic Na compound on the surface for coverages up to 1 monolayer (ML). This strongly-bound Na diffuses into the MnO subsurface and bulk at elevated temperatures above 500 K. For Na coverages above 1 ML, metallic Na is present and desorbs from the surface below 500 K. The deposition of Na on MnO(100) follows a Stranski-Krastanov (SK) growth mode, with the formation of metallic Na islands following completion of the first Na monolayer. After Na deposition, the surface exhibits a diffuse (1 × 1) LEED pattern, suggesting the formation of disordered Na overlayers. After heating to 1000 K, the surface presents a (2 × 2) LEED pattern indicating that a surface reconstruction is induced by the diffusion of Na into the near surface region. CO2 can be used as a probe molecule in TPD to distinguish between metallic Na islands and oxidic Na in the first ML, and to indicate when Na that is still observable by XPS goes subsurface.

  2. Jezična analiza lista Naš glas

    OpenAIRE

    2015-01-01

    U radu se analizira jezik Našega glasa (list „Riviere“ – radne organizacije za ugostiteljstvo, turizam, trgovinu i proizvodnju) koji je izlazio u Poreču od 1969. do 1982. godine. Nakon kratkoga osvrta na strukturu, sadržaj i ulogu toga lista te njegov značaj za stanovništvo lokalne zajednice, slijedi prikaz jezičnih zbivanja u vrijeme njegova izlaženja. U žarištu su istraživanja pravopisne, morfološke, sintaktičke, tvorbene, leksičke i stilske karakteristike lista. Rezultati istraživanja poka...

  3. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Menu Contact Dictionary Search About Cancer Causes and Prevention Risk Factors Genetics Cancer Prevention Overview Research Cancer Screening Cancer Screening Overview Screening ...

  4. Childhood Cancer Statistics

    Science.gov (United States)

    ... Room Employment Feedback Contact Select Page Childhood Cancer Statistics Home > Cancer Resources > Childhood Cancer Statistics Childhood Cancer Statistics – Graphs and Infographics Number of Diagnoses Incidence Rates ...

  5. Comparação da linfocintilografia com dextrano 500 com a do fitato na pesquisa do linfonodo sentinela no câncer de mama Lymphoscintigraphy imaging study for sentinel node mapping, comparing dextran 500 with phytate, in breast cancer patients

    Directory of Open Access Journals (Sweden)

    Nilton Leite Xavier

    2005-06-01

    Full Text Available OBJETIVO: comparar a acurácia de dois radiocolóides na marcação do linfonodo sentinela (LNS por imagem. MÉTODOS: as pacientes foram incluídas no período de maio de 2002 a abril de 2004. Neste estudo duplo-cego, a paciente foi submetida duas vezes ao mesmo exame, mas com fármacos diferentes, sendo que os fármacos, tecnécio-99m-dextrano 500 (dextrano e tecnécio-99m-fitato (fitato, foram injetados, na mama, em quatro pontos na área peritumoral e no subcutâneo superficialmente ao tumor, com volume de 2 ml, contendo de 1,0 a 1,5 mCi, em alíquotas de 0,4 ml. Para a obtenção das imagens, duas horas após a injeção do radiofármaco, usamos gama-câmera com colimador de alta resolução. A drenagem linfática axilar foi identificada em imagens radiográficas estáticas, anterior e lateral. A estatística para pares discordantes foi realizada pelo teste de MacNemar e pelo teste Z para proporções. RESULTADOS: na análise das 40 pacientes, obtiveram-se 15 pares com imagens positivas iguais, 4 pares com imagens negativas e 21 pares com imagens distintas, seja porque uma era negativa, seja porque o número de LNS marcados era diferente. A análise do desempenho quanto ao sucesso e insucesso mostrou 35 e 27 imagens positivas e 5 e 13 imagens negativas, respectivamente para o dextrano e o fitato, sendo que das negativas 4 eram comuns. O estudo estatístico pelo teste de MacNemar mostrou p=0,026, com odds ratio (OR = 0,11 e IC 95% 0,01PURPOSE: a case-control study comparing two radiocolloids used in scintigraphy to map the sentinel lymph nodes (SLN in breast cancer patients. METHODS: forty patients were prospectively enrolled between May 2002 and April 2004, after signing an informed consent form. In the present double-blind study, each patient was submitted twice to the same examination, a mammary scintigraphy, one with 99mTc-dextran 500 (dextran and the other with 99mTc-phytate (phytate, on different days. A volume of 2 ml with 1-1.5 mCi of

  6. Corpo e sexualidade na gravidez

    Directory of Open Access Journals (Sweden)

    Natalúcia Matos Araújo

    2012-06-01

    Full Text Available Estudo etnográfico que teve como objetivo compreender como as gestantes vivenciam os processos fisiológicos do seu corpo durante a gestação e a sua repercussão na sexualidade. A pesquisa envolveu sete mulheres residentes em bairro popular de São Paulo. Na coleta de dados, utilizou-se observação participante e entrevista com questões norteadoras. Os dados foram apresentados na forma de narrativa e posteriormente organizados nas categorias: Percebendo as transformações corporais; Convivendo com as mudanças no corpo; Sentimentos e sensações na vida sexual durante a gestação e imaginando o corpo e a sexualidade após a gestação. As mulheres referiram-se às transformações do corpo como desconfortos e expressaram a preocupação de que fossem definitivas. Expressaram o desejo de que, após o parto, o corpo volte a ser como era e que volte a sentir desejo sexual. O reconhecimento destes fatos constitui-se numa ferramenta primordial na adequação das práticas profissionais.

  7. All new for NA62

    CERN Multimedia

    Antonella Del Rosso

    2012-01-01

    This week sees the start of the first run of the new NA62 experiment. This will be a unique opportunity for the collaboration to test its new beam, new detectors and new data acquisition system before the physics run in 2014. Speaking to the Bulletin, the NA62 technical coordinator Ferdinand Hahn shares the many challenges that the various teams faced to be on time for beam. Ready, steady, start!   A Large Angle Veto detector (white) in place in the NA62 decay volume (blue). With components from almost all the detectors in place downstream of the decay point of the mother particles – the kaons – and of the KTAG detector that tags the kaons before they decay, NA62 is ready for its first technical run. This unique run will test all the equipment as well as the trigger and the data acquisition systems. “This year, we will have about five weeks of beam from the SPS before the long shutdown of all the CERN machines,” says Ferdinand Hahn, NA62 Technical Co-...

  8. Alcool e drogas na esquizofrenia

    OpenAIRE

    Marilia Montoya Boscolo

    2000-01-01

    Resumo: O objetivo deste trabalho é estudar o fenômeno do uso de álcool e drogas ilícitas (maconha e cocaína) na esquizoftenia. Trata-se de estudo comparativo, casocontrole, de dois grupos de esquizoftênicos pareados para sexo e idade, que preencheram os critérios diagnósticos do DSMIV para esquizoftenia. O grupo caso é definido por esquizofrênicos que têm história de ter feito uso de álcool, pelo menos no último mês e/ ou história de ter feito uso de drogas (maconha e cocaína), pelo menos al...

  9. Criatividade na Gestalt–terapia

    Directory of Open Access Journals (Sweden)

    Patrícia Albuquerque Lima

    2009-04-01

    Full Text Available Como se conceitua criatividade na teoria da Gestalt–terapia? Qual o papel e a função da criatividade nesta abordagem? O que se considera como um comportamento criativo no senso comum é tão diferente do que compreendemos, na abordagem gestáltica, como criatividade? Estas são algumas das perguntas sobre as quais buscaremos transcorrer ao longo deste artigo. Partimos de simples perguntas, pois talvez um bom recurso para se “tratar” da criatividade seja a curiosidade. Para isto, iremos apresentar a contribuição de alguns autores que discorreram sobre o tema da criatividade em suas obras, iniciando por Kurt Goldstein e sua Teoria Organísmica, que consideramos o principal substrato teórico para se pensar a criatividade na Gestalt–terapia.

  10. gigapanorama of NA 62 cavern

    CERN Multimedia

    Brice, Maximilien

    2015-01-01

    The image shows the new rare Kaon decay experiment at CERN, called NA62. The NA62 experiment is 270 metres long and includes a 120-metre-long vacuum tank, shown here, housing several of the particle detectors. (Note: the experiment axis is a straight line, the curving of the tank is an optical effect of the photo.) Kaons are particles that decay into lighter elementary particles. The kaon decay processes are mostly well known, except for some very rare decay modes. For example, NA62 is investigating a rare decay predicted by the Standard Model in which a kaon decays into one pion and two neutrinos. This process occurs only once every 10 billion decays. The understanding of such ultra-rare decays are of great importance because they test the Standard Model in energy ranges not accessible by direct measurements. They are therefore complementary to the measurements at the LHC. ultra high definition on demand (photolab@cern.ch).

  11. Adaptação dos adolescentes com cancro na fase de tratamento: uma revisão da literatura Adaptación de los adolescentes con cáncer durante el tratamiento: una revisión de la literatura Adaptation of adolescents with cancer during treatment: a literature review

    Directory of Open Access Journals (Sweden)

    Manuel G. H. Gameiro

    2012-12-01

    Full Text Available O cancro na adolescência é uma experiência especialmente crítica. Os adolescentes com cancro têm de enfrentar as exigências do confronto com a ameaça vital e o sofrimento relacionados com a doença e os tratamentos, em simultâneo com os desafios e as condições desenvolvimentais próprios da sua fase etária. Com o propósito central de conhecer “como se caracteriza e se processa a adaptação dos adolescentes com cancro durante o tratamento”, realizámos uma revisão sistemática da literatura empírica indexada em bases de dados online. Foram analisados 15 artigos publicados desde o ano 2000. Dos resultados, salienta-se alguma consistência entre as evidências empíricas geradas, nomeadamente acerca dos mecanismos de confronto e de ajustamento e sobre as respostas adaptativas comuns nesta população. São enunciadas novas perspetivas e evocados outros fenómenos a necessitarem de mais investigação, em particular centrada no processo de adaptação, enquanto transição pessoal. São ainda deduzidas algumas implicações para a prática de enfermagem.El cáncer en la adolescencia es una experiencia especialmente crítica. Los adolescentes con cáncer tienen que enfrentarse a las exigencias de la confrontación con la amenaza vital y el sufrimiento relacionados con la enfermedad y los tratamientos, al mismo tiempo que lo hacen a los desafíos y condiciones de su fase de desarrollo. Con el principal propósito de saber “cómo se caracteriza y se procesa la adaptación de los adolescentes con cáncer durante el tratamiento”, hemos realizado una revisión sistemática de la literatura empírica indexada en bases de datos en línea. Se analizaron 15 artículos publicados desde el año 2000. A partir de los resultados, se destacada una cierta consistencia entre las evidencias empírica generadas, en particular en relación a los mecanismos de confrontación y de ajuste y sobre las respuestas de adaptación comunes en esta poblaci

  12. The meaning of being a man with intestinal stoma due to colorectal cancer: an anthropological approach to masculinities El significado de ser un hombre com estoma intestinal por cáncer de colorectal: un abordaje antropológico de la masculinidad Os sentidos de ser homem com estoma intestinal por câncer colorretal: uma abordagem na antropologia das masculinidades

    Directory of Open Access Journals (Sweden)

    Eliza Maria Rezende Dázio

    2009-10-01

    Full Text Available This study analyzes the meanings that men with intestinal stoma attribute to their colorectal cancer experience and its treatment. The medical anthropology framework, gender identity and the ethnographic methods were used. A total of 16 men from 40 to 79 years of age, residents in Ribeirão Preto and neighboring cities, SP, Brazil participated in the study. Data collection was carried out through participant observation and semi-structured interviews. Two groups of meanings were selected through inductive data analysis: acknowledging the severity of the disease and the distress of having cancer, and being submitted to surgery and suffering from a stoma. These meanings revealed the tension that develops between traditional patterns of masculinity and the new identities resulting from the experience. The understanding of these meanings from a cultural perspective favors nurse-patient communication and enables planning of care appropriate to these patients' needs.El estudio tuvo como objetivo analizar el significado que los hombres, con estoma intestinal, atribuyen a la experiencia de la enfermedad y al tratamiento de cáncer de colorectal. Fueron utilizadas las referencias teóricas de la antropología médica, de la masculinidad y del método etnográfico. Participaron del estudio 16 hombres en el intervalo de edad de 40 a 79 años, residentes en Ribeirao Preto, SP, y región. La recolección de los datos fue realizada por medio de observaciones participantes y entrevistas semiestructuradas. Por medio del análisis inductivo de los datos, se seleccionó de los núcleos de significados: el reconocimiento de la gravedad de la enfermedad y el sufrimiento de tener cáncer, someterse a la cirugía y al estoma. Esos significados revelan la tensión que se desarrolla entre los estándares tradicionales de masculinidad y las nuevas formas de identidad provocadas por la experiencia. Conocer esos significados, bajo la perspectiva cultural, facilita la

  13. Criatividade na Gestalt–terapia

    OpenAIRE

    Patrícia Albuquerque Lima

    2009-01-01

    Como se conceitua criatividade na teoria da Gestalt–terapia? Qual o papel e a função da criatividade nesta abordagem? O que se considera como um comportamento criativo no senso comum é tão diferente do que compreendemos, na abordagem gestáltica, como criatividade? Estas são algumas das perguntas sobre as quais buscaremos transcorrer ao longo deste artigo. Partimos de simples perguntas, pois talvez um bom recurso para se “tratar” da criatividade seja a curiosidade. Para isto, iremos apresentar...

  14. Cats, Cancer and Comparative Oncology

    Directory of Open Access Journals (Sweden)

    Claire M. Cannon

    2015-06-01

    Full Text Available Naturally occurring tumors in dogs are well-established models for several human cancers. Domestic cats share many of the benefits of dogs as a model (spontaneous cancers developing in an immunocompetent animal sharing the same environment as humans, shorter lifespan allowing more rapid trial completion and data collection, lack of standard of care for many cancers allowing evaluation of therapies in treatment-naïve populations, but have not been utilized to the same degree in the One Medicine approach to cancer. There are both challenges and opportunities in feline compared to canine models. This review will discuss three specific tumor types where cats may offer insights into human cancers. Feline oral squamous cell carcinoma is common, shares both clinical and molecular features with human head and neck cancer and is an attractive model for evaluating new therapies. Feline mammary tumors are usually malignant and aggressive, with the ‘triple-negative’ phenotype being more common than in humans, offering an enriched population in which to examine potential targets and treatments. Finally, although there is not an exact corollary in humans, feline injection site sarcoma may be a model for inflammation-driven tumorigenesis, offering opportunities for studying variations in individual susceptibility as well as preventative and therapeutic strategies.

  15. Estudo epidemiológico de câncer na adolescência em centro de referência Estudio epidemiológico de cáncer en la adolescencia en centro de referencia Epidemiological study of cancer in adolescents at a referral center

    Directory of Open Access Journals (Sweden)

    Paula de Figueiredo Presti

    2012-06-01

    Full Text Available OBJETIVO: Analisar as características epidemiológicas dos adolescentes portadores de neoplasias encaminhados para o Instituto de Oncologia Pediátrica (IOP/GRAACC da Universidade Federal de São Paulo, entre os anos de 2000 a 2006. MÉTODOS: Trata-se de um estudo retrospectivo descritivo, em que foram avaliados os dados epidemiológicos dos pacientes, com idade entre dez e19 anos ao diagnóstico, admitidos do ano 2000 a 2006 no IOP/Graacc. RESULTADOS: Do total de 2.362 pacientes admitidos neste período com diagnóstico de câncer, 629 (26,6% eram adolescentes. A idade média encontrada foi de 13,8 anos, sendo a maioria do sexo masculino (56,8%. Em relação à raça, 60,7% dos pacientes eram brancos. Os tipos de tumores mais frequentes foram: tumores de sistema nervoso central (22,1%, osteossarcoma (14,6%, linfomas (14,5% e leucemias (14,5%. A sobrevida global, em cinco anos, dos 629 pacientes deste estudo foi de 73,7%. Destaca-se que os adolescentes com rabdomiossarcoma apresentavam doença disseminada e histologia de pior prognóstico, contribuindo para o aumento na taxa de mortalidade deste grupo de pacientes. CONCLUSÕES: Os adolescentes com câncer correspondem a um grupo de pacientes que apresenta características peculiares quando comparado a outros grupos oncológicos. Há diferença histológica dos tumores dos adolescentes com os da infância, em que predominam leucemias e tumores do sistema nervoso central. Nesse contexto, é fundamental facilitar o acesso desses pacientes a centros especializados e oferecer meios apropriados para o diagnóstico precoce e tratamento adequado.OBJETIVO: Analizar las características epidemiológicas de los adolescentes portadores de neoplasias encaminados al Instituto de Oncología Pediátrica (IOP/GRAACC de la Universidad Federal de São Paulo, entre los años 2000 a 2006. MÉTODOS: Se trata de un estudio retrospectivo descriptivo, en el que fueron evaluados los datos epidemiológicos de los

  16. Determination of the (Na+) Sternheimer antishielding factor by 23Na NMR spectroscopy on sodium oxide chloride, Na3OCl.

    Science.gov (United States)

    Klösters, G; Jansen, M

    2000-07-01

    The (Na+) Sternheimer antishielding factor gammainifinity (Na+) was determined by 23Na NMR spectroscopy on sodium oxide-chloride, Na3OCl. The quadrupolar coupling constant of the sodium ion in Na3OCI was determined to QCC = 11.34 MHz, which presents the largest coupling constant of a sodium nucleus observed so far. Applying a simple point charge model, the largest principal value of the electric field gradient at the sodium site was calculated to V(zz) = -6.76762 x 10(20) V/m2. From these values we calculated the (Na+) Sternheimer antishielding factor to gammainifinity (Na+)= -5.36. In sodium oxide, Na2O, we observed an isotropic chemical shift of deltaCS = 55.1 ppm, referenced to 1 M aqueous NaCI (delta = 0 ppm).

  17. Lymphedema After Surgery in Patients With Endometrial Cancer, Cervical Cancer, or Vulvar Cancer

    Science.gov (United States)

    2014-12-23

    Lymphedema; Stage IA Cervical Cancer; Stage IA Uterine Corpus Cancer; Stage IA Vulvar Cancer; Stage IB Cervical Cancer; Stage IB Uterine Corpus Cancer; Stage IB Vulvar Cancer; Stage II Uterine Corpus Cancer; Stage II Vulvar Cancer; Stage IIA Cervical Cancer; Stage IIIA Vulvar Cancer; Stage IIIB Vulvar Cancer; Stage IIIC Vulvar Cancer; Stage IVB Vulvar Cancer

  18. An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells

    Directory of Open Access Journals (Sweden)

    Li Zhang

    2015-01-01

    Full Text Available Hydrogen sulfide (H2S can be synthesized in mammalian cells by cystathionine γ-lyase (CSE and/or cystathionine β-synthase (CBS. Both CSE and CBS are expressed in rat gastric tissues but their role in human gastric neoplasia has been unclear. The aims of the present study were to detect CSE and CBS proteins in human gastric cancer and determine the effect of exogenous NaHS on the proliferation of gastric cancer cells. We found that both CSE and CBS proteins were expressed in human gastric cancer cells and upregulated in human gastric carcinoma mucosa compared with those in noncancerous gastric samples. NaHS induced apoptosis of gastric cancer cells by regulating apoptosis related proteins. Also, NaHS inhibited cancer cell migration and invasion. An antigastric cancer role of H2S is thus indicated.

  19. Stress related to care: the impact of childhood cancer on the lives of parents Estrés relacionado al cuidado: el impacto del cáncer infantil en la vida de los padres Estresse relacionado ao cuidado: o impacto do câncer infantil na vida dos pais

    Directory of Open Access Journals (Sweden)

    Daniela Fernanda dos Santos Alves

    2013-02-01

    Full Text Available OBJECTIVES: The objective was to assess the stress levels of parents of children with cancer and to identify correlations among demographic data and anxiety levels. METHODS: A descriptive, cross-sectional study, conducted in two Brazilian institutions, with 101 parents of children with cancer. Through interviews, parents responded to two instruments: Pediatric Inventory for Parents - Brazilian version, which assesses stress levels, and State-Trait Anxiety Inventory, for the measurement of anxiety. The correlations between the instruments and the sociodemographic variables of the parents and children were evaluated using the Spearman correlation coefficient. RESULTS: Higher levels of stress and anxiety were seen by young parents, young children and with less time since diagnosis. The fear of death and the disease impact on the life of a child were the events considered the most stressful for the parents . CONCLUSIONS: In clinical practice, the nurse who can identify the occurrence of these symptoms becomes capable of planning nursing care that includes the family in decisions about the care. Moreover, she can provide support to help parents manage their stress levels and positively face the illness of their children.OBJETIVOS: El objetivo fue evaluar el nivel de estrés de los padres de niños con cáncer e identificar correlaciones entre los datos sociodemográficos y los niveles de ansiedad. MÉTODO: Estudio descriptivo transversal, realizado en dos instituciones brasileñas, con 101 padres de niños con cáncer. A través de entrevista, los padres contestaron a dos instrumentos: Pediatric Inventory for Parents - versión brasileña, que evalúa niveles de estrés, e Inventário de Ansiedade Traço-Estado, para medir la ansiedad. Las correlaciones entre los instrumentos y las variables sociodemográficas de los padres y de los niños fueron evaluados por el Coeficiente de Correlación de Spearman. RESULTADOS: Los más altos niveles de estrés y

  20. Li Na Aces French Open

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Chinese tennis player becomes the first Asian to win a Grand Slam singles title Chinese tennis player Li Na beat defending champion Francesca Schiavone from Italy,6-4,7-6,on the clay court at Roland Garros,winning the 2011 French Open Tennis Tournament on June 4.She made history by becoming the first Chinese to win a grand slam singles title.

  1. NA62: Hidden Sector Physics

    CERN Document Server

    Cesarotti, Carissa Joyce

    2016-01-01

    Modern experimental physics is often probing for new physics by either finding deviations from predictions on extremely precise measurements, or by looking for a new signal that cannot be explained with existing models. The NA62 experiment at CERN does the former by measuring the ultra-rare decay $K^+ \\rightarrow \\pi^+ \

  2. NA60 frees the quarks

    CERN Multimedia

    2003-01-01

    Fitted with new state-of-the-art silicon detectors, NA60 is prepared to study the phase transition from confined hadronic matter to a deconfined (free) quark-gluon plasma, a state of matter which probably existed an instant after the Big Bang.

  3. Astrocytes generate Na+-mediated metabolic waves.

    Science.gov (United States)

    Bernardinelli, Yann; Magistretti, Pierre J; Chatton, Jean-Yves

    2004-10-12

    Glutamate-evoked Na+ increase in astrocytes has been identified as a signal coupling synaptic activity to glucose consumption. Astrocytes participate in multicellular signaling by transmitting intercellular Ca2+ waves. Here we show that intercellular Na+ waves are also evoked by activation of single cultured cortical mouse astrocytes in parallel with Ca2+ waves; however, there are spatial and temporal differences. Indeed, maneuvers that inhibit Ca2+ waves also inhibit Na+ waves; however, inhibition of the Na+/glutamate cotransporters or enzymatic degradation of extracellular glutamate selectively inhibit the Na+ wave. Thus, glutamate released by a Ca2+ wave-dependent mechanism is taken up by the Na+/glutamate cotransporters, resulting in a regenerative propagation of cytosolic Na+ increases. The Na+ wave gives rise to a spatially correlated increase in glucose uptake, which is prevented by glutamate transporter inhibition. Therefore, astrocytes appear to function as a network for concerted neurometabolic coupling through the generation of intercellular Na+ and metabolic waves.

  4. Europlanet NA2 Science Networking

    Science.gov (United States)

    Harri, Ari-Matti; Szego, Karoly; Genzer, Maria; Schmidt, Walter; Krupp, Norbert; Lammer, Helmut; Kallio, Esa; Haukka, Harri

    2013-04-01

    Europlanet RI / NA2 Science Networking [1] focused on determining the major goals of current and future European planetary science, relating them to the Research Infrastructure that the Europlanet RI project [2] developed, and placing them in a more global context. NA2 also enhanced the ability of European planetary scientists to participate on the global scene with their own agenda-setting projects and ideas. The Networking Activity NA2 included five working groups, aimed at identifying key science issues and producing reference books on major science themes that will bridge the gap between the results of present and past missions and the scientific preparation of the future ones. Within the Europlanet RI project (2009-2012) the NA2 and NA2-WGs organized thematic workshops, an expert exchange program and training groups to improve the scientific impact of this Infrastructure. The principal tasks addressed by NA2 were: • Science activities in support to the optimal use of data from past and present space missions, involving the broad planetary science community beyond the "space club" • Science activities in support to the preparation of future planetary missions: Earth-based preparatory observations, laboratory studies, R&D on advanced instrumentation and exploration technologies for the future, theory and modeling etc. • Develop scientific activities, joint publications, dedicated meetings, tools and services, education activities, engaging the public and industries • Update science themes and addressing the two main scientific objectives • Prepare and support workshops of the International Space Science Institute (ISSI) in Bern and • Support Trans National Activities (TNAs), Joined Research Activities (JRAs) and the Integrated and Distributed Information Service (IDIS) of the Europlanet project These tasks were achieved by WG workshops organized by the NA2 working groups, by ISSI workshops and by an Expert Exchange Program. There were 17 official WG

  5. The Na+/H+ exchanger controls deoxycholic acid-induced apoptosis by a H+-activated, Na+-dependent ionic shift in esophageal cells.

    Directory of Open Access Journals (Sweden)

    Aaron Goldman

    Full Text Available Apoptosis resistance is a hallmark of cancer cells. Typically, bile acids induce apoptosis. However during gastrointestinal (GI tumorigenesis the cancer cells develop resistance to bile acid-induced cell death. To understand how bile acids induce apoptosis resistance we first need to identify the molecular pathways that initiate apoptosis in response to bile acid exposure. In this study we examined the mechanism of deoxycholic acid (DCA-induced apoptosis, specifically the role of Na(+/H(+ exchanger (NHE and Na(+ influx in esophageal cells. In vitro studies revealed that the exposure of esophageal cells (JH-EsoAd1, CP-A to DCA (0.2 mM-0.5 mM caused lysosomal membrane perturbation and transient cytoplasmic acidification. Fluorescence microscopy in conjunction with atomic absorption spectrophotometry demonstrated that this effect on lysosomes correlated with influx of Na(+, subsequent loss of intracellular K(+, an increase of Ca(2+ and apoptosis. However, ethylisopropyl-amiloride (EIPA, a selective inhibitor of NHE, prevented Na(+, K(+ and Ca(2+ changes and caspase 3/7 activation induced by DCA. Ouabain and amphotericin B, two drugs that increase intracellular Na(+ levels, induced similar changes as DCA (ion imbalance, caspase3/7 activation. On the contrary, DCA-induced cell death was inhibited by medium with low a Na(+ concentrations. In the same experiments, we exposed rat ileum ex-vivo to DCA with or without EIPA. Severe tissue damage and caspase-3 activation was observed after DCA treatment, but EIPA almost fully prevented this response. In summary, NHE-mediated Na(+ influx is a critical step leading to DCA-induced apoptosis. Cells tolerate acidification but evade DCA-induced apoptosis if NHE is inhibited. Our data suggests that suppression of NHE by endogenous or exogenous inhibitors may lead to apoptosis resistance during GI tumorigenesis.

  6. Complicações na rede venosa de mulheres com câncer de mama durante tratamento quimioterápico Complicaciones en la red venosa de mujeres con cáncer de mama durante tratamiento quimioterapéutico Complications in the venous network of women with breast cancer during chemotherapy treatment

    Directory of Open Access Journals (Sweden)

    Elga Zacharias Martins

    2010-01-01

    Full Text Available OBJETIVOS: Identificar as reações da rede venosa, investigar a frequência e as características dessas reações em mulheres com câncer de mama durante o tratamento quimioterápico. MÉTODOS: Foram avaliados 339 prontuários de mulheres submetidas à quimioterapia, de 2003 a 2007. RESULTADOS: Durante os tratamentos neoadjuvantes e adjuvantes 17,1% e 22,4% mulheres apresentaram intercorrências registradas no prontuário, sendo as frequentes: extravasamento, dor e alteração na coloração da pele. As condutas mais citadas na neoadjuvância foram: utilização de compressas frias (2,9% e aplicação de glicocorticoide subcutâneo no local (3,5% e na adjuvância foram: aplicação de hidrocortisona subcutâneo no local (3,2%, aplicação do protocolo de extravasamento (6,2% e utilização de compressas de gelo (7,1%. CONCLUSÃO: O registro das intercorrências e o relato da equipe de enfermagem são essenciais para o acompanhamento dos sítios de punções venosas utilizados durante o tratamento quimioterápico, além de mensuração e registro fotográfico do local.OBJETIVOS: Identificar las reacciones de la red venosa e investigar la frecuencia y las características de esas reacciones en mujeres con cáncer de mama durante el tratamiento quimioterapéutico. MÉTODOS: Fueron evaluadas 339 fichas de mujeres sometidas a quimioterapia, de 2003 a 2007. RESULTADOS: Durante los tratamientos neo-adyuvantes y adyuvantes (17,1% y 22,4% las mujeres presentaron ocurrencias registradas en fichas, siendo las más frecuentes: infiltración externa, dolor y, alteración en la coloración de la piel. Las conductas neo-adyuvantes más citadas fueron: utilización de compresas frías (2,9% y aplicación de glucocorticoide subcutáneo en el local (3,5%, y las adyuvantes fueron: aplicación de hidrocortisona subcutánea en el local (3,2%, aplicación del protocolo de infiltración externa (6,2% y utilización de compresas de hielo (7,1%. CONCLUSIÓN: El

  7. Cancer immunotherapy

    DEFF Research Database (Denmark)

    Cairns, Linda; Aspeslagh, Sandrine; Anichini, Andrea

    2016-01-01

    This report covers the Immunotherapy sessions of the 2016 Organisation of European Cancer Institutes (OECI) Oncology Days meeting, which was held on 15th-17th June 2016 in Brussels, Belgium. Immunotherapy is a potential cancer treatment that uses an individual's immune system to fight the tumour....... In recent years significant advances have been made in this field in the treatment of several advanced cancers. Cancer immunotherapies include monoclonal antibodies that are designed to attack a very specific part of the cancer cell and immune checkpoint inhibitors which are molecules that stimulate...... or block the inhibition of the immune system. Other cancer immunotherapies include vaccines and T cell infusions. This report will summarise some of the research that is going on in this field and will give us an update on where we are at present....

  8. Cancer in Patients With Gabapentin (GPRD)

    Science.gov (United States)

    2012-02-02

    Pain, Neuropathic; Epilepsy; Renal Pelvis Cancer; Pancreatic Cancer; Breast Cancer; Nervous System Cancer; Chronic Pancreatitis; Stomach Cancer; Renal Cell Carcinoma; Diabetes; Bladder Cancer; Bone and Joint Cancer; Penis Cancer; Anal Cancer; Cancer; Renal Cancer

  9. Cervical Cancer

    Centers for Disease Control (CDC) Podcasts

    2007-03-06

    Did you know that cervical cancer rates differ by race/ethnicity and region? Or that cervical cancer can usually be prevented if precancerous cervical lesions are found by a Pap test and treated? Find out how getting regular Pap tests can save a woman's life.  Created: 3/6/2007 by National Breast and Cervical Cancer Early Detection Program.   Date Released: 4/25/2007.

  10. Efeitos do treinamento de resistência na força muscular e níveis de fadiga em pacientes com câncer de mama Los efectos de los ejercicios de resistencia sobre varios músculos y niveles de fatiga en pacientes con cáncer de mama The effects of resistance training on muscular strength and fatigue levels in breast cancer patients

    Directory of Open Access Journals (Sweden)

    Claudio Battaglini

    2006-06-01

    Full Text Available Os efeitos de programas generalizados de atividade física no combate ao câncer e aos efeitos colaterais de seu tratamento têm sido amplamente relatados na literatura. O objetivo do presente estudo foi o de examinar os efeitos de um programa de prescrição de exercício físico individualizado, com ênfase no treinamento resistido, na força muscular e nos níveis de fadiga em pacientes portadoras de câncer de mama em tratamento. Vinte mulheres foram divididas aleatoriamente em dois grupos, sendo um experimental (57,5 ± 23,0 anos e um controle (56,6 ± 16,0 anos. O grupo experimental exercitou-se, após a cirurgia, durante 60 minutos, de forma moderada, duas vezes por semana, durante 21 semanas. A força muscular total foi avaliada antes e após o tratamento e os níveis de fadiga foram avaliados em três momentos durante o treinamento. Foram encontradas diferenças significativas na força muscular total entre os grupos após o treinamento (p = 0,025. Os níveis de fadiga diminuíram significativamente entre os grupos após a primeira (p = 0,001 e a segunda (p = 0,005 intervenção e ao final do tratamento (p = 0,001. Os resultados deste estudo sugerem que os exercícios resistidos devem ser incluídos na prescrição de exercícios no combate da fadiga e na melhoria da força muscular em mulheres com câncer de mama, submetidas a tratamento.Los efectos de programas generalizados de actividad física de combate al cáncer y los efectos colaterales de su tratamiento vienen siendo bastante estudiados. El objetivo del presente estudio ha sido el de examinar los efectos de un programa prescrito de ejercicio físico individual, con énfasis en el entrenamiento resistido, en la fuerza muscular y en los niveles de fatiga en pacientes portadoras de cáncer de mama en tratamiento. Veinte mujeres fueron divididas aleatoriamente en dos grupos, siendo uno de ellos el experimental (57,5 ± 23,0 años y el otro de control (56,6 ± 16,0 años. El grupo

  11. Verdade na Cena, Verdade na Vida: Boal e Stanislavski

    Directory of Open Access Journals (Sweden)

    Antonia

    2015-04-01

    Full Text Available À luz do conceito de verdade cênica, o presente artigo discute a influência do método Stanislavski nos primeiros experimentos no seio do Teatro Arena de São Paulo e também aponta rastros do mestre russo nos princípios da Poética do Oprimido de Augusto Boal. O objetivo primordial consiste em incentivar a construção de espetáculos-fórum, partindo de um trabalho com rigor físico e detalhamento psicológico stanislavskianos. Trabalho este, que pode ser desenvolvido na lógica interna do processo, na fase que precede a todo produto de criação, antes da intervenção do espectador e no âmbito de montagens profissionais de teatro-fórum, em projetos mais duradouros.

  12. Lung Cancer Screening

    Science.gov (United States)

    ... Treatment Lung Cancer Prevention Lung Cancer Screening Research Lung Cancer Screening (PDQ®)–Patient Version What is screening? Go ... These are called diagnostic tests . General Information About Lung Cancer Key Points Lung cancer is a disease in ...

  13. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Adult Cancers Metastatic Cancer Recurrent Cancer Research NCI’s Role in Cancer Research Intramural Research Extramural Research Bioinformatics ... Terminology Resources NCI Data Catalog Cryo-EM NCI's Role in Cancer Research Intramural Research Extramural Research Bioinformatics ...

  14. Hereditary Diffuse Gastric Cancer

    Science.gov (United States)

    ... Hereditary Diffuse Gastric Cancer Request Permissions Hereditary Diffuse Gastric Cancer Approved by the Cancer.Net Editorial Board , 11/2015 What is hereditary diffuse gastric cancer? Hereditary diffuse gastric cancer (HDGC) is an inherited ...

  15. Stomach (Gastric) Cancer Prevention

    Science.gov (United States)

    ... Stomach Cancer Prevention Stomach Cancer Screening Research Stomach (Gastric) Cancer Prevention (PDQ®)–Patient Version What is prevention? Go ... has stayed about the same since 2005. Stomach (gastric) cancer is a disease in which malignant (cancer) cells ...

  16. What Is Lung Cancer?

    Science.gov (United States)

    ... Graphics Infographic Stay Informed Cancer Home What Is Lung Cancer? Language: English Español (Spanish) Recommend on Facebook Tweet ... cancer starts in the lungs, it is called lung cancer. Lung cancer begins in the lungs and may ...

  17. Skin Cancer Screening

    Science.gov (United States)

    ... Genetics of Skin Cancer Skin Cancer Screening Research Skin Cancer Screening (PDQ®)–Patient Version What is screening? ... These are called diagnostic tests . General Information About Skin Cancer Key Points Skin cancer is a disease ...

  18. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... about Advanced Cancer Research Managing Cancer Care Finding Health Care Services Costs & Medical Information Advance Directives Using ... Cancer Advanced Cancer & Caregivers Managing Cancer Care Finding Health Care Services Managing Costs and Medical Information Advance ...

  19. Breast Cancer Research Update

    Science.gov (United States)

    ... JavaScript on. Feature: Breast Cancer Breast Cancer Research Update Winter 2017 Table of Contents National Cancer Institute ... Addressing Breast Cancer's Unequal Burden / Breast Cancer Research Update Winter 2017 Issue: Volume 11 Number 4 Page ...

  20. Children's cancer centers

    Science.gov (United States)

    Pediatric cancer center; Pediatric oncology center; Comprehensive cancer center ... Treating childhood cancer is not the same as treating adult cancer. The cancers are different. So are the treatments and the ...

  1. Testicular Cancer Screening

    Science.gov (United States)

    ... Health Professional Testicular Cancer Treatment Testicular Cancer Screening Testicular Cancer Screening (PDQ®)–Patient Version What is screening? Go ... These are called diagnostic tests . General Information About Testicular Cancer Key Points Testicular cancer is a disease in ...

  2. Learning about Colon Cancer

    Science.gov (United States)

    ... What do we know about heredity and colon cancer? Colon cancer, a malignant tumor of the large intestine, ... page Additional Resources for Information on Hereditary Colon Cancer Colon and Rectal Cancer Information [cancer.gov] The most ...

  3. Influência da invasão tumoral da linha de anastomose na sobrevivência de pacientes com câncer de coto gástrico The influence of tumor invasion in anastomotic line on survival of patient with gastric stump cancer

    Directory of Open Access Journals (Sweden)

    Ana Lúcia Granja Scarabel Nogueira Carrasco

    2008-06-01

    Full Text Available RACIONAL: O câncer do coto gástrico desenvolve- se no remanescente gástrico de gastrectomia realizada há pelo menos 5 anos por doença benigna e os sítios mais comuns de acometimento são próximo à anastomose e na pequena curvatura. Considera-se que o coto gástrico é estado pré-canceroso. OBJETIVOS: Identificar o padrão de disseminação de linfonodos acometidos, quantificar a invasão tumoral da linha de anastomose e correlacionar: a invasão da linha de anastomose com o comprometimento linfonodal e mesenterial, o acometimento linfonodal com sobrevivência e o acometimento da linha de anastomose com sobrevivência. MÉTODOS: Estudo retrospectivo com revisão de prontuários, peças cirúrgicas e exames anátomo-patológicos de 113 pacientes com diagnóstico de câncer de coto gástrico definido como adenocarcinoma desenvolvido no remanescente gástrico de gastrectomia realizada há pelo menos cinco anos por doença benigna. RESULTADOS: A disseminação linfonodal não se mostrou específica; 75% dos pacientes apresentaram invasão tumoral da linha de anastomose; em 66,7% dos casos ocorreu invasão da linha anastomótica e linfonodal concomitantes; menos de 10% dos casos exibiam invasão mesenterial; houve óbito em 86,5% dos casos com invasão linfonodal e 64,7% com invasão da linha de anastomose e em 100% com invasão mesenterial. CONCLUSÕES: 1 O câncer de coto gástrico não tem padrão de disseminação linfonodal específico; 2 a linha de anastomose sofre freqüente invasão tumoral; 3 apesar de freqüente a invasão da linha anastomótica, não apresenta correlação estatística significante com o comprometimento linfonodal regional ou mesenterial; 4 a presença de invasão linfonodal implica em sobrevida menor, em especial a de linfonodos do mesentério; 5 a presença de acometimento neoplásico da linha anastomótica não se correlaciona com pior resultado de sobrevivência.AIM: To identify the lymph node metastatic

  4. Ontario-wide Cancer TArgeted Nucleic Acid Evaluation

    Science.gov (United States)

    2016-09-14

    Breast Cancer; Lung Cancer; Colorectal Cancer; Melanoma; Gynecological Cancer; Genitourinary Cancer; Pancreatobiliary Cancer; Gastrointestinal Cancer; Head and Neck Cancer; Rare Cancer; Unknown Primary Cancer

  5. Pathophysiology of cancer cachexia

    Directory of Open Access Journals (Sweden)

    Riad N. Younes

    2000-10-01

    Full Text Available Cancer cachexia is a frequent complication observed in patients with malignant tumors. Although several decades have passed since the first focus on the metabolic dysfunction's associated with cancer, few effective therapeutic interventions have been successfully introduced into the medical armamentarium. The present study thoroughly reviews the basic pathophysiology of cancer cachexia and the treatment options already investigated in that field. Experimental and clinical studies were evaluated individually in order to clarify the intricate alterations observed in tumor-bearing patients. The difficulties in introducing sound and effective nutritional support or metabolic manipulation to reverse cancer cachexia are outlined in this review.A caquexia é uma complicação freqüentemente observada em pacientes portadores de tumores malignos. Apesar de várias décadas transcorrerem desde a descrição inicial das disfunções metabólicas associadas ao câncer, poucas medidas terapêuticas foram induzidas com sucesso na prática médica. O presente estudo apresenta uma revisão detalhada da fisiopatologia básica da caquexia em câncer, e as opções terapêuticas desenvolvidas nesta área. Estudos experimentais, assim como clínicos, são avaliados individualmente para esclarecer as alterações complexas observadas em pacientes portadores de tumores. As dificuldades encontradas para introduzir manipulações metabólicas e terapias de suporte nutricional eficientes são discutidas nesta revisão.

  6. Spraakrevalidatie na een totale laryngectomie

    NARCIS (Netherlands)

    Timmermans, A.J.; Krap, M.; Hilgers, F.J.M.; van den Brekel, M.W.M.

    2012-01-01

    In patients with advanced laryngeal or hypopharyngeal cancer, or in cases when the disease recurs after treatment with (chemo)radiation, a total laryngectomy (TLE) is performed. For them to be able to function properly, speech rehabilitation is of the utmost importance for these patients. For voice

  7. Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Scott Eggener

    2011-01-01

    Full Text Available Prostate cancer continues to be a significant public health issue worldwide, particularly in countries where men have life expectancies long enough to clinically manifest the disease. In many countries, it remains one of the leading causes of cancer-related morbidity and mortality.

  8. Renal cancer

    NARCIS (Netherlands)

    Corgna, Enrichetta; Betti, Maura; Gatta, Gemma; Roila, Fausto; De Mulder, Pieter H. M.

    2007-01-01

    In Europe, renal cancer (that is neoplasia of the kidney, renal pelvis or ureter (ICD-9 189 and ICD-10 C64-C66)) ranks as the seventh most common malignancy in men amongst whom there are 29,600 new cases each year (3.5% of all cancers). Tobacco, obesity and a diet poor in vegetables are all acknowle

  9. Skin Cancer

    Science.gov (United States)

    ... you ever get a bad sunburn that caused blisters when you were a child?Does your skin ... Cancer InstituteMelanoma International FoundationAmerican Cancer Society ResourcesDiagnosis and Management of Malignant Melanoma by BG Goldstein, AO Goldstein( ...

  10. Occupational Cancer

    Science.gov (United States)

    ... Regulation and Policy OSHA Standards Surveillance NIOSH Data & Statistics by Industry Sector - Cancer Click on one of the eight Sector Tabs at the top of the screen to find available cancer statistics for that Sector Work-Related Lung Disease Surveillance ...

  11. NA

    OpenAIRE

    1994-01-01

    Significant research in high performance analog-to-digital converters (ADCs) has been directed at retaining part of the high-speed flash ADC architecture, while reducing the total number of comparators in the circuit. The symmetrical number system (SNS) can be used to preprocess the analog input signal, reducing the number of comparators and thus reducing the chip area and power consumption of the ADC. This thesis examines a Very Large Scale Integrated (VLSI) design for a folding circuit for ...

  12. Hrvatska milja na starim kartama

    Directory of Open Access Journals (Sweden)

    Marina Viličić

    2016-06-01

    Full Text Available Karta Stjepana Glavača iz 1673. godine vrijedan je i jedinstven primjerak hrvatske kartografske baštine. Na njoj je ucrtana hrvatska milja kojoj nema traga na kartama izrađenima prije Glavačeve karte. Više autora spominje vrijednost duljine hrvatske milje, ali nisu suglasni s iznosom njezine vrijednosti. Za potrebe ovoga rada, pored kopije Glavačeve karte pribavljene su i istražene kopije karata Janeza Vajkarda Valvasora iz 1689., Giacoma Cantellija da Vignole iz 1690., Antuna Belavića iz 1739. i karta Kraljevinâ Dalmacije, Hrvatske i Slavonije… iz 1746. na kojima je, pored ostalih milja, ucrtana i hrvatska milja. S pomoću tih ucrtanih milja izračunan je odnos između hrvatske i njemačke milje, zatim talijanske i hrvatske milje te potom francuske i hrvatske milje. Pored tih odnosa, dan je i pregled odnosa hrvatske milje i nekih drugih milja. Utvrđeno je da je duljina hrvatske milje jednaka 1/10 duljine ekvatorskog stupnja. Duljina hrvatske milje za Zemljin radijus R = 6371 km iznosi 11 120 m, odnosno približno 11 km.

  13. Corpo e velhice na contemporaneidade

    Directory of Open Access Journals (Sweden)

    Gabriela Felten da Maia

    2014-04-01

    Full Text Available A inegável atenção dada ao corpo na sociedade inspirou a construção deste trabalho, visto que os imperativos atuais são a beleza, a forma e o vigor. A velhice e a inexorabilidade da morte apresentam-se para este ideal como incômodos que devem ser afastados através de diversos hábitos "saudáveis" e “rejuvenescedores”, como a ginástica, os cosméticos, as vitaminas, procedimentos estético-cirúrgicos, entre outros. O modo de “ser velho”, então, passa a ser configurado não mais por estereótipos negativos, mas a partir de um ethos em que os idosos são apresentados como saudáveis, joviais, engajados, produtivos e autoconfiantes. São corpos que ultrapassam as marcas do tempo, atléticos, firmes e lisos. Logo, aqueles que não aderem a este ethos podem tornar-se desviantes, estranhos, velhos, ultrapassados e precisam, portanto, serem descartados ou escamoteados. Tendo em vista estas questões, o presente trabalho propõe-se a discutir sobre o tema velhice, corpo e sociedade, na tentativa de problematizar sobre os atuais modos de subjetivação e o envelhecimento na contemporaneidade.

  14. Ambiguidade: modo de ser da mulher na prevenção secundária do câncer de mama Ambigüedad: modo de ser de la mujer en la prevención secundaria del cancer de mama Ambiguity: woman's manner of being in the secondary prevention of the breast cancer

    Directory of Open Access Journals (Sweden)

    Maria Carmen Simões Cardoso de Melo

    2012-03-01

    -cisión por la prevención secundaria. La construcción del concepto de ser y desvelamiento del sentido, pueden cimentar la práctica asistencial del enfermero y favorecer el cuidado singular, integral y humano, que privilegia el oír atento al vivido del ser-mujer, en su movimiento existencial de in-comprensiones y indagaciones.The breast cancer magnitude impose valorizing the knowledge and acting before the disease and its precocious detection. In this study, of qualitative nature, guided by the phenomenology and based on the theoretical-methodological thinking of Martin Heidegger, it searched for hearing the being-woman-who-belongsto the-familiar-risk-group, with the aim at analyzing comprehensively her meanings of secondary prevention. Before empathic relation and reduction of presuppositions, there were interviewed thirteen women indicated by theirs clients familiars. The hermeneutics made possible the interpretative comprehension of the being-there, who showed facets of its existential dimension. Guided by the talking and fear, under the ambiguity domain, it does not recognize as being of possibilities. It lacks better comprehension to move itself to the de-cision by the secondary prevention. The construction of the concept of being and the sense revelation, can support the nurse' s assistance practice and favor the singular, integral and human care, that privileges the attentive hearing to the lived of the being-woman, in her existential movement of in-comprehensions and questions.

  15. Impact of extended lymphadenectomy on morbidity, mortality, recurrence and 5-year survival after gastrectomy for cancer: meta-analysis of randomized clinical trials Impacto da linfadenectomia ampliada na morbidade, mortalidade, recidiva e cinco anos de sobrevida após gastrectomia por câncer: metanálise de ensaios clínicos randomizados

    Directory of Open Access Journals (Sweden)

    Suzana Angélica Silva Lustosa

    2008-12-01

    Full Text Available PURPOSE: To compare morbidity, mortality, recurrence and 5-year survival between D1 and D2 or D3 for treatment of gastric cancer. METHODS: Systematic review and meta-analysis of RCTs. Metaview in RevMan 4.2.8 for analysis; statistical heterogeneity by Cochran's Q test (P50%. Estimates of effect were calculated using random effects model. RESULTS: D2 or D3 was associated with higher in-hospital mortality, with RR = 2.13, p=0.0004, 95% CI, 1.40 to 3.25, I²=0%, P=0.63; overall morbidity showed higher incidence in D2 or D3, RR = 1.98, pOBJETIVO: Comparar a morbidade, mortalidade, recidiva e sobrevida de cinco anos entre linfadenectomia D1 e D2 ou D3 no tratamento do câncer gástrico. MÉTODOS: Revisão sistemática metanálise de ensaios clínicos randomizados, programa Metaview, Revman 4.2.8. Heterogeneidade estatística pelo teste Q de Cochrane (P50%. Estimativas dos efeitos pelo modelo randômico. RESULTADOS: Maior mortalidade hospitalar em D2 ou D3, RR = 2.13, p=0.0004, 95% IC, 1.40 a 3.25, I²=0%, P=0.63; maior morbidade geral em D2 ou D3, RR = 1.98, p<0.00001, 95% IC, 1.64 a 2.38, I² = 33.9%, P=0.20; maior tempo operatório em D2 e D3, diferença de média ponderal de 1.05, p<0.00001, 95% IC, 0.71 a 1.38, I² = 78.7%, P=0.03; número de reoperações maior em D2 e D3, RR = 2.33, p<0.0001, 95% IC, 1.58 a 3.44, I² = 0%, P=0.99; maior tempo de permanência hospitalar em D2 e D3, diferença de média ponderal de 4.72, p<0.00001, 95% IC, 3.80 a 5.65, I² = 89.9%, P<0.00001; recidiva maior nos grupos D2 e D3, RR = 0.89, p=0.02, 95% IC, 0.80 a 0.98, I² = 71.0%, P = 0.03; mortalidade com doença recidivada maior em D1, RR = 0.88, p=0.04, 95% IC, 0.78 a 0.99, I² =51.8%, P=0.10; 5 anos de sobrevida mostrou diferença estatística não significante, RR = 1.05, p=0.40, 95% IC, 0.93 a 1.19, I² = 49.1% e P=0.12. CONCLUSÕES: Linfadenectomia D2 ou D3 está associada a maior morbidade e maior mortalidade intra-hospitalar; D2 ou D3 apresenta menor incid

  16. Homocisteína Homocysteine

    Directory of Open Access Journals (Sweden)

    Lindalva Batista Neves

    2004-10-01

    Full Text Available A homocisteína, formada a partir da metionina hepática, é metabolizada nas vias de desmetilação e de transulfuração, sendo que seus valores plasmáticos e urinários refletem a síntese celular. Sua determinação, realizada em jejum e após sobrecarga de metionina, caracteriza as diferenças dessas vias metabólicas, principalmente quando de natureza genética. A hiper-homocisteinemia tem sido associada a maior risco de eventos aterotrombóticos, e a literatura sugere associação causal, independente de outros fatores de risco para doença arterial. Diminuição da homocisteína plasmática para valores normais é seguida de redução significante na incidência de doença aterotrombótica. A relação entre homocisteína e o fígado vem adquirindo importância nos dias atuais, uma vez que alterações das lipoproteínas e da depuração de metionina são comuns em pacientes com doença hepática crônica (hepatocelular e canalicular. O tratamento da hiper-homocisteinemia fundamenta-se na suplementação alimentar e medicamentosa de ácido fólico e vitaminas B6 e B12.Homocysteine, formed from hepatic methionine, is metabolized through the pathways of demethylation and transsulfuration. Its plasmatic and urinary values reflect the cell synthesis. Its determination after fasting and increased infusion of methionine shows the differences of these two metabolic pathways, mainly when it is related to genetic diseases. Hyperhomocysteinemia has been associated with a higher risk of vascular thrombotic events. Several authors suggest a causal relationship between these events independently of other risk factors for vascular diseases. Decrease in plasmatic homocysteine to normal levels is followed by a significant reduction on the incidence of vascular thrombotic events. The correlation between the liver and homocysteine is becoming more important because of the recent findings that alterations of lipoproteins and methionine clearance are

  17. Utjecaj načina zrenja na udjel vode u bezmasnoj tvari i na udjel masti u siru Trapistu

    OpenAIRE

    Kirin, Slavko

    2001-01-01

    U radu je istraživan utjecaj načina zrenja na udjel vode u bezmasnoj tvari i na udjel masti u siru Trapistu. U sadašnjoj proizvodnji (Lura, Tvornica Bjelovar), sir Trapist zrije na prirodan način s oblikovanjem kore, te vakuumski upakiran u termoskupljajuče plastične vrećice, čime se dobije sir bez kore. Utvrđeno je da spomenuti načini zrenja uvjetuju signifikantne razlike u udjelu vode u bezmasnoj tvari sira. On je 5,34 % viši kod sira Trapista u vrećici u odnosu na sir Trapist s korom. Udje...

  18. Na+,K+-ATPase Na+ affinity in rat skeletal muscle fiber types

    DEFF Research Database (Denmark)

    Kristensen, Michael; Juel, Carsten

    2010-01-01

    Previous studies in expression systems have found different ion activation of the Na(+)/K(+)-ATPase isozymes, which suggest that different muscles have different ion affinities. The rate of ATP hydrolysis was used to quantify Na(+),K(+)-ATPase activity, and the Na(+) affinity of Na(+),K(+)-ATPase...

  19. Can Thyroid Cancer Be Prevented?

    Science.gov (United States)

    ... Thyroid Cancer Causes, Risk Factors, and Prevention Can Thyroid Cancer Be Prevented? Most people with thyroid cancer have ... Cancer? Can Thyroid Cancer Be Prevented? More In Thyroid Cancer About Thyroid Cancer Causes, Risk Factors, and Prevention ...

  20. Breast Cancer -- Male

    Science.gov (United States)

    ... Home > Types of Cancer > Breast Cancer in Men Breast Cancer in Men This is Cancer.Net’s Guide to Breast Cancer in Men. Use the menu below to choose ... social workers, and patient advocates. Cancer.Net Guide Breast Cancer in Men Introduction Statistics Risk Factors and Prevention ...

  1. A Perspectiva de estudos sobre os sujeitos na Arquivologia, na Biblioteconomia e na Museologia

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Ávila Araújo

    2015-01-01

    Full Text Available Arquivologia, Biblioteconomia e Museologia se constituíram, como disciplinas científicas, no final do século XIX, a partir da consolidação de um modelo custodial patrimonialista e, depois, com sua superação a partir de duas perspectivas: uma funcionalista e outra crítica. Posteriormente, uma outra tradição de pesquisa se desenvolveu: estudos realizados a partir do ponto de vista dos sujeitos (usuários, públicos que se relacionam com as instituições arquivo, biblioteca, museu, e que experimentam seus espaços e se apropriam dos conteúdos de seus acervos. O objetivo deste texto é analisar o desenvolvimento desta perspectiva na Arquivologia, na Biblioteconomia e na Museologia, bem como defender a importância de um diálogo maior entre os achados de pesquisa realizados neste âmbito em cada uma das três áreas analisadas.

  2. NaCl Potentiates Human Fibrocyte Differentiation

    OpenAIRE

    Nehemiah Cox; Darrell Pilling; Gomer, Richard H.

    2012-01-01

    Excessive NaCl intake is associated with a variety of fibrosing diseases such as renal and cardiac fibrosis. This association has been attributed to increased blood pressure as the result of high NaCl intake. However, studies in patients with high NaCl intake and fibrosis reveal a connection between NaCl intake and fibrosis that is independent of blood pressure. We find that increasing the extracellular concentration of NaCl to levels that may occur in human blood after high-salt intake can p...

  3. Conversion and Distribution of Lead and Tin in NaOH-NaNO3 Fusion Process

    Science.gov (United States)

    Liu, Jingxin; Guo, Xueyi

    2017-04-01

    Oxidizing alkali fusion process has been studied to extract amphoteric metals. Transformation and distribution behaviors of typical amphoteric metals Pb and Sn in the NaOH-NaNO3 fusion process are systemically studied by theoretical analysis and experimental verification done in this work. Functions of NaOH and NaNO3 in the fusion process were also investigated. The results show the fused products, Na2PbO3 and Na2SnO3, are captured in the flux, and Na2PbO4 is speculated to reduce to Pb(II) in the following leaching process. By measuring solubility data of NaOH-Na2SnO3-PbO-H2O system, a strategy of crystallization is proposed to separate Sn with Pb in concentrated alkaline solution, and slice Na2Sn(OH)6 is obtained as a product.

  4. The hydrogen storage properties of Na decorated small boron cluster B6Na8

    Science.gov (United States)

    Tang, Chunmei; Wang, Zhiguo; Zhang, Xue; Wen, Ninghua

    2016-09-01

    The binding energy of the Na atoms to the hollow sites of the B6 cage is larger than the experimental cohesive energy of bulk Na, so the clustering of Na atoms can be avoided. The polarization interaction dominates the adsorption of H2 by the B6Na8 cluster. The Na-coated B6Na8sbnd B8sbnd B6Na8 complex with the dispersive Na atoms and four H2 molecules adsorbed per Na can serve as better building blocks of polymers than the (B6Na8)2 dimer. These findings suggest a new route to design cluster-assembled hydrogen storage materials based on sp2-terminated boron chains.

  5. Management of patients with advanced prostate cancer

    DEFF Research Database (Denmark)

    Gillessen, S; Omlin, A; Attard, G

    2015-01-01

    -resistant prostate cancer and the recent studies of chemo-hormonal therapy in men with castration-naïve prostate cancer have led to considerable uncertainty as to the best treatment choices, sequence of treatment options and appropriate patient selection. Management recommendations based on expert opinion......The first St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) Expert Panel identified and reviewed the available evidence for the ten most important areas of controversy in advanced prostate cancer (APC) management. The successful registration of several drugs for castration...... decisions on treatment as always will involve consideration of disease extent and location, prior treatments, host factors, patient preferences as well as logistical and economic constraints. Inclusion of men with APC in clinical trials should be encouraged....

  6. Silicene for Na-ion battery applications

    Science.gov (United States)

    Zhu, Jiajie; Schwingenschlögl, Udo

    2016-09-01

    Na-ion batteries are promising candidates to replace Li-ion batteries in large scale applications because of the advantages in natural abundance and cost of Na. Silicene has potential as the anode in Li-ion batteries but so far has not received attention with respect to Na-ion batteries. In this context, freestanding silicene, a graphene-silicene-graphene heterostructure, and a graphene-silicene superlattice are investigated for possible application in Na-ion batteries, using first-principles calculations. The calculated Na capacities of 954 mAh/g for freestanding silicene and 730 mAh/g for the graphene-silicene superlattice (10% biaxial tensile strain) are highly competitive and potentials of \\gt 0.3 {{V}} against the Na{}+/Na potential exceed the corresponding value of graphite. In addition, the diffusion barriers are predicted to be \\lt 0.3 {eV}.

  7. Silicene for Na-ion battery applications

    KAUST Repository

    Zhu, Jiajie

    2016-08-19

    Na-ion batteries are promising candidates to replace Li-ion batteries in large scale applications because of the advantages in natural abundance and cost of Na. Silicene has potential as the anode in Li-ion batteries but so far has not received attention with respect to Na-ion batteries. In this context, freestanding silicene, a graphene-silicene-graphene heterostructure, and a graphene-silicene superlattice are investigated for possible application in Na-ion batteries, using first-principles calculations. The calculated Na capacities of 954mAh/g for freestanding silicene and 730mAh/g for the graphenesilicene superlattice (10% biaxial tensile strain) are highly competitive and potentials of >0.3 V against the Na/Na potential exceed the corresponding value of graphite. In addition, the diffusion barriers are predicted to be <0.3 eV.

  8. Role of gambogic acid and NaI131 in A549/DDP cells

    Science.gov (United States)

    Huang, Jing; Zhu, Xiaoli; Wang, Huan; Han, Shuhua; Liu, Lu; Xie, Yan; Chen, Daozhen; Zhang, Qiang; Zhang, Li; Hu, Yue

    2017-01-01

    Resistance to platinum in tumor tissue is a considerable barrier against effective lung cancer treatment. Radionuclide therapy is the primary adjuvant treatment, however, the toxic side effects limit its dosage in the clinical setting. Therefore, the present study aimed to determine whether an NaI131 radiosensitizer could help reduce the toxic side effects of radionuclide therapy. In vitro experiments were conducted to determine whether NaI131 can inhibit platinum resistance in A549/DDP cells, which are cisplatin-resistant non-small cell lung cancer cells, and whether gambogic acid (GA) is an effective NaI131 radiosensitizer. Cell proliferation following drug intervention was analyzed using MTT and isobolographic analysis. Apoptosis was assessed by flow cytometry. In addition, the mechanisms of drug intervention were analyzed by measuring the expression of P-glycoprotein (P-gP), B cell lymphoma 2 (Bcl-2), Bcl2-associated X protein (Bax) and P53 using western blot analysis and immunocytochemistry. According to isobolographic analysis, a low concentration of NaI131 combined with GA had a synergistic effect on the inhibition of A549/DDP cell proliferation, which was consistent with an increased rate of apoptosis. Furthermore, the overexpression of Bax, and the downregulation of P-gP, P53 and Bcl-2 observed demonstrated the potential mechanism(s) of NaI131 and GA intervention. NaI131 may induce apoptosis in A549/DDP cells by regulating apoptosis-related proteins. A low concentration combination of NaI131 and GA was able to significantly inhibit A549/DDP cell proliferation and induce cell apoptosis. Thus, the two drugs appear to have a synergistic effect on apoptosis of A549/DDP cells. PMID:28123519

  9. Stress related to care: the impact of childhood cancer on the lives of parents Estrés relacionado al cuidado: el impacto del cáncer infantil en la vida de los padres Estresse relacionado ao cuidado: o impacto do câncer infantil na vida dos pais

    OpenAIRE

    Daniela Fernanda dos Santos Alves; Edinêis de Brito Guirardello; Andréa Yamaguchi Kurashima

    2013-01-01

    OBJECTIVES: The objective was to assess the stress levels of parents of children with cancer and to identify correlations among demographic data and anxiety levels. METHODS: A descriptive, cross-sectional study, conducted in two Brazilian institutions, with 101 parents of children with cancer. Through interviews, parents responded to two instruments: Pediatric Inventory for Parents - Brazilian version, which assesses stress levels, and State-Trait Anxiety Inventory, for the measurement of anx...

  10. Raltegravir in treatment naïve patients

    Directory of Open Access Journals (Sweden)

    Cossarini F

    2009-11-01

    Full Text Available Abstract Raltegravir is the first integrase inhibitor approved for the treatment of HIV infection based on the superior efficacy it showed compared to optimized backbone therapy alone in patients harboring multidrug resistant viruses. Studies on naïve patients showed comparable efficacy of raltegravir and efavirenz and just recently the US Food and Drug Administration (FDA approved raltegravir for the use in naïve patients based on the favorable results of the international double-blind phase III STARTMRK trial. Additional interesting findings were the faster, and not yet explained, decay of HIV-1 RNA and the higher CD4+ cells increase in the raltegravir group as compared to the efavirenz group. Raltegravir is generally well tolerated and adverse events were generally similar in raltegravir and comparator arms throughout all studies. When compared to efavirenz, patients on raltegravir showed less incidence of central nervous system-related adverse events. In studies on experienced patients higher incidence of cancers was found in the raltegravir arm: a relationship with the drug was, however not confirmed in a recent review considering all raltegravir studies. Raltegravir also showed a safe lipid profile expecially in naïve patients, finding that renders the drug attractive for patients with other cardiovascular risk factors. All this characteristics in association with its specific mechanism of action, make raltegravir an interesting drug for naïve patients and a large use in this type of patients is predictable. Only time and experience, however, will tell us whether raltegravir will maintain its promises in the long run.

  11. New results from NA49

    CERN Document Server

    Afanasiev, S V; Bächler, J; Barna, D; Barnby, L S; Bartke, Jerzy; Barton, R A; Behler, M; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Blyth, C O; Boimska, B; Botje, M; Bracinik, J; Brady, F P; Bramm, R; Brun, R; Buncic, P; Carr, L; Cebra, D; Cerny, V; Cooper, G E; Cramer, J G; Csató, P; Dinkelaker, P; Eckardt, V; Eckhardt, F; Ferenc, D; Filip, P; Fischer, H G; Foder, Z; Foka, P Y; Freund, P; Friese, V; Gál, J; Ganz, R E; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Harris, J W; Hegyi, S; Höhne, C; Igo, G; Jacobs, P; Jones, P G; Kadija, K; Kolesnikov, V I; Kollegger, T; Kowalski, M; Kraus, I; Kreps, M; Lasiuk, B; Van Leeuwen, M; Lévai, Peter; Malakhov, A I; Margetis, S; Markert, C; Mayes, B W; Melkumov, G L; Mischke, A; Molnár, J; Nelson, J M; Odyniec, Grazyna Janina; Oldenburg, M; Pálla, G; Panagiotou, A D; Perl, K; Petridis, A; Pikna, M; Pinsky, L; Poskanzer, A M; Prindle, D J; Pühlhofer, F; Putschke, J; Reid, J G; Renfordt, A; Retyk, W; Ritter, H G; Röhrich, D; Roland, C; Roland, G; Rybicki, A; Sammer, T; Sann, H; Schäfer, E; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Snellings, R; Squier, G T A; Stock, Reinhard; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Toy, M; Trainor, T A; Trentalange, S; Ullrich, T S; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Voloshin, S A; Vranic, D; Wang, F; Weerasundara, D D; Wenig, S; Wetzler, A; Whitten, C; Xu, N; Yates, T A; Koo, I K; Zaranek, J; Zimányi, J

    2002-01-01

    Recent results of the NA49 experiment are presented. These cover first results on pion and kaon production, HBT, and charge fluctuations from Pb+Pb reactions at 40 AGeV and their comparison to 158 AGeV beam energy. Furthermore a study on baryon number transfer in p+p, centrality selected p+Pb and Pb+Pb collisions at 158 AGeV and new results on the system size dependence of kaon yields, including C+C and Si+Si data, are presented. Additionally, a first result on Lambda Lambda correlations is shown. (11 refs).

  12. The NA52 strangelet search

    CERN Document Server

    Weber, M; Baglin, C; Beck, H P; Borer, K; Bussière, A; Elsener, K; Gorodetzky, P; Guillaud, J P; Kabana, S; Klingenberg, R; Lehmann, G; Lindén, T; Lohmann, K D; Mommsen, R K; Moser, U; Pretzl, Klaus P; Schacher, J; Spiwoks, R; Tuominiemi, Jorma

    2001-01-01

    The NA52 experiment searches for long-lived charged strangelets in 158 a GeV c/sup -1/ Pb+Pb collisions at CERN SPS. The experiment is able to identify single particles coming from the collisions at p/sub t/=0. We collected 10/sup 13/ Pb+Pb interactions looking for negatively charged strangelets and 3*10/sup 11/ Pb+Pb interactions for positively charged ones. No evidence for the production of strangelets has been observed. We present here resulting experimental differential and total upper production limits. (8 refs).

  13. Pneumonia bacteriana adquirida na comunidade

    OpenAIRE

    Machado, Lais Del Prá Netto

    2015-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2015. A pneumonia pode ser causada por diversos microrganismos e classificada de forma abrangente, havendo poucos e frágeis estudos clínicos e epidemiológicos sobre pneumonias adquiridas na comunidade (PACs). Os patógenos mais frequentes nas PACs são Streptococcus pneumoniae e Haemophilus influenzae (em pneumonias típicas) e Mycoplasma pneumoni...

  14. Cervical Cancer

    Science.gov (United States)

    ... vaginal, and vulvar cancers. It is recommended for preteens (both boys and girls) aged 11 to 12 ... index. • D on’t smoke. • Use condoms during sex. * • Limit your number of sexual partners. * HPV infection ...

  15. Eye Cancer

    Science.gov (United States)

    ... underneath the retina that contains connective tissue and melanocytes, which are pigmented (colored) cells, and nourishes the ... cancer in adults. It begins when cells called melanocytes grow uncontrollably. Intraocular melanoma is also called uveal ...

  16. Ovarian Cancer

    Science.gov (United States)

    ... the ovary, fallopian tube, and peritoneum: Epidemiology and risk factors. http://www.uptodate.com/home. Accessed Feb. 18, 2014. Havrilesky LJ, et al. Oral contraceptive pills as primary prevention for ovarian cancer: A systematic ...

  17. Testicular Cancer

    Science.gov (United States)

    ... or testicles that aren't shaped normally.Have Klinefelter's syndrome (a genetic condition where male infants are born ... contributed by: familydoctor.org editorial staff Tags: cryptorehidism, Klinefelter's syndrome, malignancies, scrotal mass, scrotal masses, testicular cancer, testicular ...

  18. Cancer nanotheranostics

    CERN Document Server

    Gopinath, P; Matai, Ishita; Bhushan, Bharat; Malwal, Deepika; Sachdev, Abhay; Dubey, Poornima

    2015-01-01

    This Brief provides a clear insight of the recent advances in the field of cancer theranostics with special emphasis upon nano scale carrier molecules (polymeric, protein and lipid based) and imaging agents (organic and inorganic).

  19. Stomach cancer

    Science.gov (United States)

    ... the stomach for a long time (chronic atrophic gastritis ) Have pernicious anemia (low number of red blood ... HealthProfessional . Accessed December 21, 2016. Read More Cancer Gastritis Malignancy Pernicious anemia Review Date 11/10/2016 ...

  20. Esophageal cancer.

    Science.gov (United States)

    Vakil, Nimish; Affi, Aboud

    2002-07-01

    Despite advances in our knowledge of esophageal cancer, 50% of patients present with incurable disease, and the overall survival after diagnosis is poor. The incidence of esophageal adenocarcinoma of the distal esophagus is rising at a rapid rate in developed countries. Recent advances in the epidemiology of esophageal cancer offer insights into preventive strategies in patients who are at risk. New developments in diagnosis may help detect the disease at an early stage. New diagnostic modalities permit more accurate staging procedures and allow appropriate selection of therapy. New studies provide more information on multimodality therapy for esophageal cancer, and new endoscopic techniques allow resection of small lesions without surgery. New stent designs provide better palliation by providing tumor ingrowth. These developments in the treatment of esophageal cancer are the focus of this review.

  1. Cancer Today

    Science.gov (United States)

    ... inactivity, nutrition, sun exposure, and even exposure to infectious agents, such as hepatitis B, human papillomavirus, or helicobacter ... The extramural research program reaches nearly 650 universities, hospitals, cancer centers, and other sites in the United ...

  2. Thyroid Cancer

    Science.gov (United States)

    ... you may be eligible to receive a medication (potassium iodide) that blocks the effects of radiation on the ... occur, you and your family could take the potassium iodide tablets to help prevent thyroid cancer. Contact your ...

  3. Prostate Cancer

    Science.gov (United States)

    ... may help you cope with your distress, including: Art therapy Dance or movement therapy Exercise Meditation Music ... www.mayoclinic.org/diseases-conditions/prostate-cancer/basics/definition/CON-20029597 . Mayo Clinic Footer Legal Conditions and ...

  4. Esophageal Cancer

    Science.gov (United States)

    ... Resources Conducting Clinical Trials Statistical Tools and Data Terminology Resources NCI Data Catalog Cryo-EM NCI's Role ... Contacts Other Funding Find NCI funding for small business innovation, technology transfer, and contracts Training Cancer Training ...

  5. Cancer Statistics

    Science.gov (United States)

    ... Resources Conducting Clinical Trials Statistical Tools and Data Terminology Resources NCI Data Catalog Cryo-EM NCI's Role ... Contacts Other Funding Find NCI funding for small business innovation, technology transfer, and contracts Training Cancer Training ...

  6. Vaginal cancer

    Science.gov (United States)

    Hacker NF. Vulvar and vaginal cancer. In: Hacker NF, Gambone JC, Hobel CJ, eds. Hacker and Moore's Essentials of Obstetrics and Gynecology . 6th ed. Philadelphia, PA: Elsevier; 2016:chap 40. Jhingran ...

  7. Cervical Cancer

    Science.gov (United States)

    ... Other things may increase the risk of developing cancer following a high-risk HPV infection. These other things include: Smoking Having HIV or reduced immunity Taking birth control pills for a long time ( ...

  8. Prostate cancer

    DEFF Research Database (Denmark)

    Chabanova, Elizaveta; Balslev, Ingegerd; Logager, Vibeke

    2011-01-01

    To investigate diagnostic accuracy of detection of prostate cancer by magnetic resonance: to evaluate the performance of T2WI, DCEMRI and CSI and to correlate the results with biopsy and radical prostatectomy histopathological data.......To investigate diagnostic accuracy of detection of prostate cancer by magnetic resonance: to evaluate the performance of T2WI, DCEMRI and CSI and to correlate the results with biopsy and radical prostatectomy histopathological data....

  9. Cancer nanotechnology

    Directory of Open Access Journals (Sweden)

    Jagdale Swati

    2009-01-01

    Full Text Available Cancer nanotechnology is the latest trend in cancer therapy. It helps the pharmacist to formulate the product with maximum therapeutic value and minimum or negligible range side effects. Cancer is the disease in which the abnormal cells are quite similar to the normal cell with just minute functional or genetic change. Thus, it is very hard to target the abnormal cells by the conventional method of the drug delivery system. Nanotechnology is probably the only method that can be used for site-specific action without causing the side effects by killing the normal cells. This review article describes the possible way to exploit the nanotechnology to targeted drug therapy in cancer. The various methods used are: systemic delivery systems, passive targeting, active targeting, intracellular delivery, subcellular localization, and nanoparticle drugs. Different cancer detection techniques like carbon nanotubes, nanorods, and biosensors are also available. This review article gives an idea about the possible potential of nanotechnology in drug delivery, drug targeting, and the diagnosis of cancer.

  10. Identidades Homossexuais na Territorialidade Tradicionalista

    Directory of Open Access Journals (Sweden)

    Edipo Djavan dos Reis Göergen

    2015-12-01

    Full Text Available Este artigo apresenta o debate teórico que sustenta a pesquisa de mestrado desenvolvida pelo autor. Tendo por base suas vivências em contextos de tradicionalismo gaúcho, o autor deste trabalho tem percebido a grande quantidade de homossexuais, ou indivíduos que se auto-denominam não-heterossexuais, integrando as atividades artísticas do Movimento Tradicionalista Gaúcho, ou a territorialidade tradicionalista. Interessado em investigar tal fenômeno, o autor tem desenvolvido o projeto de pesquisa “Os Espaços Paradoxais de Relações Homoeróticas na Territorialidade Tradicionalista”, sob orientação do prof. Dr. Benhur Pinós da Costa, no Programa de Pós-Graduação em Geografia (UFSM. Para que essa pesquisa seja realizada, levam-se em conta as relações de gênero e de sexualidade que estão envolvidas no tema. Dessa forma, por ainda se tratarem de temáticas tidas como insignificantes na sociedade em geral e marginalizadas no campo científico, para que o presente trabalho fosse empreendido, buscou-se amparo teórico nas geografias feministas e queer, segmentos contemporâneos da ciência geográfica.

  11. NaCl potentiates human fibrocyte differentiation.

    Science.gov (United States)

    Cox, Nehemiah; Pilling, Darrell; Gomer, Richard H

    2012-01-01

    Excessive NaCl intake is associated with a variety of fibrosing diseases such as renal and cardiac fibrosis. This association has been attributed to increased blood pressure as the result of high NaCl intake. However, studies in patients with high NaCl intake and fibrosis reveal a connection between NaCl intake and fibrosis that is independent of blood pressure. We find that increasing the extracellular concentration of NaCl to levels that may occur in human blood after high-salt intake can potentiate, in serum-free culture conditions, the differentiation of freshly-isolated human monocytes into fibroblast-like cells called fibrocytes. NaCl affects the monocytes directly during their adhesion. Potassium chloride and sodium nitrate also potentiate fibrocyte differentiation. The plasma protein Serum Amyloid P (SAP) inhibits fibrocyte differentiation. High levels of extracellular NaCl change the SAP Hill coefficient from 1.7 to 0.8, and cause a four-fold increase in the concentration of SAP needed to inhibit fibrocyte differentiation by 95%. Together, our data suggest that NaCl potentiates fibrocyte differentiation. NaCl-increased fibrocyte differentiation may thus contribute to NaCl-increased renal and cardiac fibrosis.

  12. NaCl potentiates human fibrocyte differentiation.

    Directory of Open Access Journals (Sweden)

    Nehemiah Cox

    Full Text Available Excessive NaCl intake is associated with a variety of fibrosing diseases such as renal and cardiac fibrosis. This association has been attributed to increased blood pressure as the result of high NaCl intake. However, studies in patients with high NaCl intake and fibrosis reveal a connection between NaCl intake and fibrosis that is independent of blood pressure. We find that increasing the extracellular concentration of NaCl to levels that may occur in human blood after high-salt intake can potentiate, in serum-free culture conditions, the differentiation of freshly-isolated human monocytes into fibroblast-like cells called fibrocytes. NaCl affects the monocytes directly during their adhesion. Potassium chloride and sodium nitrate also potentiate fibrocyte differentiation. The plasma protein Serum Amyloid P (SAP inhibits fibrocyte differentiation. High levels of extracellular NaCl change the SAP Hill coefficient from 1.7 to 0.8, and cause a four-fold increase in the concentration of SAP needed to inhibit fibrocyte differentiation by 95%. Together, our data suggest that NaCl potentiates fibrocyte differentiation. NaCl-increased fibrocyte differentiation may thus contribute to NaCl-increased renal and cardiac fibrosis.

  13. Efeito da radioterapia na função pulmonar e na fadiga de mulheres em tratamento para o câncer de mama Efecto de la radioterapia en la función pulmonar y en la fatiga de mujeres en tratamiento para el cáncer de mama Effect of radiotherapy on pulmonary function and fatigue of women undergoing treatment for breast cancer

    Directory of Open Access Journals (Sweden)

    Dayane Evellyn dos Santos

    2013-03-01

    Full Text Available O presente estudo comparou a função pulmonar e a fadiga de mulheres antes e após a radioterapia (RT adjuvante para tratamento do câncer de mama, e correlacionou a função pulmonar com a dose de radiação e fadiga. Foi conduzido um estudo observacional longitudinal envolvendo 20 mulheres. A função pulmonar foi avaliada pela espirometria (ClementClarke® e manovacuometria (GlobalMed®, modelo MVD 300, e a fadiga pelo Functional Assessment of Cancer Therapy Fatigue (FACT-F. Todas as avaliações foram realizadas antes da primeira sessão e uma semana após o término da RT adjuvante. Para a análise estatística foram utilizados os testes Wilcoxon Signed Rank Test e correlação de Spearman, adotando-se nível de significância pEl presente estudio comparó la función pulmonar y la fatiga de mujeres antes y después de la radioterapia (RT como ayudante para el tratamiento del cáncer de mama, y se correlacionó la función pulmonar con la dosis de radiación y fatiga. Fue realizado un estudio observacional longitudinal involucrando 20 mujeres. La función pulmonar fue evaluada por espirometría (ClementClarke® y manovacuometría (GlobalMed®, modelo MVD 300 y, la fatiga fue evaluada por la Functional Assessment of Cancer Therapy Fatigue (FACT-F. Todas las evaluaciones fueron realizadas antes de la primera sesión y una semana después del término de la RT. Para el análisis estadístico fueron utilizados los tests Wilcoxon Signed Rank Test y correlación de Spearman, adoptando un nivel de significancia pThis study compared the pulmonary function and fatigue in patients before and after adjuvant radiotherapy (RT and correlated the pulmonary function with the radiotherapy dose and fatigue. A longitudinal and observational study was conducted involving 20 women. Pulmonary function was evaluated by digital lung spirometry (ClementClarke® and manometry (GlobalMed®, model MVD 300 and fatigue was analyses by the Functional Assessment of

  14. Micotoxinas e Micotoxicoses na Avicultura

    Directory of Open Access Journals (Sweden)

    Santurio JM

    2000-01-01

    Full Text Available Esta revisão tem como objetivo principal mostrar, baseado em dezenas de pesquisas realizadas, os efeitos tóxicos das micotoxinas aflatoxinas, tricotecenos, zealenona e fumonisinas sobre o desempenho das aves. O descobrimento das propriedades hepatotóxicas e hepatocarcinogênicas de algumas linhagens de Aspergillus flavus e A. parasiticus em perus, na Inglaterra, no início da década de 1960, seguida pela elucidação da estrutura de seus metabólitos tóxicos, as aflatoxinas, deu novo enfoque e prioridade para a pesquisa sobre micotoxinas. Análises de aflatoxinas realizadas no Laboratório de Análises Micotoxicológicas (LAMIC da Universidade Fedaral de Santa Maria, entre os anos de 1986 e janeiro de 2000, em 15.600 amostras de alimentos destinados principalmente ao consumo animal, demonstram que no milho analisado, 41,9% das amostras estavam contaminadas por aflatoxinas. Em surtos de aflatoxicose no campo, uma das características mais marcantes é a má absorção que se manifesta como partículas de ração mal digeridas na excreta das aves. Também observa-se, em frangos e poedeiras que recebem AFL, extrema palidez das mucosas e pernas. Dietas deficientes em riboflavina ou colecalciferol (vit. D tornaram frangos sensíveis, nos índices de desenvolvimento corporal, a concentrações muito baixas de AFL. O efeito aflatoxina nos frangos é maior na fase inicial de crescimento, ou seja, quando as aves ingeriram aflatoxina nos primeiros 21 dias de vida, e quanto maior o nível de stress do lote, menor a quantidade de AFL para afetar negativamente seu desempenho, seja na produção de carne ou de ovos. As principais micotoxinas do grupo dos tricotecenos são: toxina T-2; deoxynivalenol (DON; diacetoxyscirpenol (DAS, todas produzidas através de diversas espécies de fungos do gênero Fusarium. Além dos tricotecenos, o fusarium também pode produzir zearalenona e fumonisinas. Dessas fusarium-toxinas, somente toxina T-2 gera patologias s

  15. Fotografia na Imprensa: conflitos na câmara escura

    Directory of Open Access Journals (Sweden)

    José Lúcio da Silva Menezes

    2014-07-01

    Full Text Available Este artigo recupera o teor ideológico do discurso que a Revista Veja elaborou sobre a classe trabalhadora que emergiu no cenário brasileiro, no final da década de 1970. O destaque dado aos trabalhadores como temática central resgatada, deve-se aos movimentos grevistas por eles encetados, após anos de ocultamento de sua resistência sob a repressão da ditadura civil-militar (1964-1985. Com a rebeldia operária, as matérias a respeito deste grupo, na Revista,foram se tornando mais constantes e visíveis, pois já não era mais possível, para a Revista Veja, ignorar a existência da classe operária que, com a força insurgente das greves, ocupava as ruas do Brasil.

  16. Pediatric Thyroid Cancer

    Science.gov (United States)

    ... Marketplace Find an ENT Doctor Near You Pediatric Thyroid Cancer Pediatric Thyroid Cancer Patient Health Information News media ... and neck issues, should be consulted. Types of thyroid cancer in children: Papillary : This form of thyroid cancer ...

  17. What Causes Thyroid Cancer?

    Science.gov (United States)

    ... Cancer Causes, Risk Factors, and Prevention What Causes Thyroid Cancer? Thyroid cancer is linked with a number of ... inside a cell, without an outside cause. Papillary thyroid cancer Several DNA mutations (changes) have been found in ...

  18. Anaplastic thyroid cancer

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/000352.htm Anaplastic thyroid cancer To use the sharing features on this page, ... of cancer of the thyroid gland. Causes Anaplastic thyroid cancer is an invasive type of thyroid cancer that ...

  19. Chemotherapy for Thyroid Cancer

    Science.gov (United States)

    ... Type and Stage Thyroid Cancer Treating Thyroid Cancer Chemotherapy for Thyroid Cancer Chemotherapy (chemo) uses anti-cancer drugs that are injected ... vein or muscle, or are taken by mouth. Chemotherapy is systemic therapy, which means that the drug ...

  20. What Is Liver Cancer?

    Science.gov (United States)

    ... Treatment? Liver Cancer About Liver Cancer What Is Liver Cancer? Cancer starts when cells in the body ... structure and function of the liver. About the liver The liver is the largest internal organ. It ...

  1. Surgery for Pancreatic Cancer

    Science.gov (United States)

    ... of the Tumor Pancreatic Cancer Treating Pancreatic Cancer Surgery for Pancreatic Cancer Two general types of surgery ... how far the cancer has spread. Potentially curative surgery Studies have shown that removing only part of ...

  2. Skin Cancer Foundation

    Science.gov (United States)

    ... Host a Fundraising Event | About Us | Store The Skin Cancer Foundation The Skin Cancer Foundation is the ... A "Sunscreen Gene"? Skin Cancer Facts & Statistics The Skin Cancer Foundation's Champions for Change Gala 2016 Learn ...

  3. Uterine Cancer Statistics

    Science.gov (United States)

    ... Research AMIGAS Fighting Cervical Cancer Worldwide Stay Informed Statistics for Other Kinds of Cancer Breast Cervical Colorectal ( ... Skin Vaginal and Vulvar Cancer Home Uterine Cancer Statistics Language: English Español (Spanish) Recommend on Facebook Tweet ...

  4. Breast Cancer Treatment

    Science.gov (United States)

    ... Gynecologic Cancers Breast Cancer Screening Research Breast Cancer Treatment (PDQ®)–Patient Version General Information About Breast Cancer ... Certain factors affect prognosis (chance of recovery) and treatment options. The prognosis (chance of recovery ) and treatment ...

  5. Esophageal Cancer Prevention

    Science.gov (United States)

    ... the lower part of the esophagus, near the stomach. See the following PDQ summaries for more information about esophageal cancer: Esophageal Cancer Screening Esophageal Cancer Treatment Esophageal cancer is found more ...

  6. Oral Cancer Exam

    Medline Plus

    Full Text Available ... Topics > Oral Cancer > Oral Cancer Exam Video Oral Cancer Exam Video This video shows what happens during an oral cancer examination. Quick and painless, the exam can detect ...

  7. Lung cancer - small cell

    Science.gov (United States)

    Cancer - lung - small cell; Small cell lung cancer; SCLC ... About 15% of all lung cancer cases are SCLC. Small cell lung cancer is slightly more common in men than women. Almost all cases of SCLC are ...

  8. Breast cancer screening

    Science.gov (United States)

    Mammogram - breast cancer screening; Breast exam - breast cancer screening; MRI - breast cancer screening ... performed to screen women to detect early breast cancer when it is more likely to be cured. ...

  9. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Overview Research Cancer Screening Cancer Screening Overview Screening Tests Research Diagnosis and Staging Symptoms Diagnosis Staging Prognosis ... Cancer Prevention Overview Screening Cancer Screening Overview Screening Tests Diagnosis & Staging Symptoms Diagnosis Staging Prognosis Treatment Types ...

  10. Learning about Breast Cancer

    Science.gov (United States)

    ... genetic terms used on this page Learning About Breast Cancer What do we know about heredity and breast ... Cancer What do we know about heredity and breast cancer? Breast cancer is a common disease. Each year, ...

  11. Cuidados paliativos à criança oncológica na situação do viver/morrer: a ótica do cuidar em enfermagem Cuidados paliativos al niño con cancer en la situación de vida o muerte: la óptica del cuidado en enfermería Palliative care to the onchologic child in the situation of live / die: the optics of the care in nursing

    Directory of Open Access Journals (Sweden)

    Barbara Soares Avanci

    2009-12-01

    Full Text Available Pesquisa de campo, descritiva-exploratória, com abordagem qualitativa, realizada em 2009, que objetivou conhecer a percepção do enfermeiro diante da criança com câncer sob cuidados paliativos; e discutir como essa percepção do enfermeiro interfere nos cuidados prestados à criança com câncer sob cuidados paliativos. Os sujeitos foram cinco enfermeiros do setor de pediatria do HEMORIO, e a interpretação das falas ocorreu por meio da análise temática. Percebemos que o cuidar da criança com câncer sob cuidados paliativos é um processo de sofrimento e um misto de emoções para o profissional, e que os cuidados voltam-se para a promoção do conforto, pelo alívio da dor e dos sintomas, além do atendimento às necessidades biopsicossociais e espirituais, e do apoio à família. Conclui-se que é necessário enfatizar a importância da assistência de enfermagem no cuidado paliativo à criança com câncer, principalmente sob a ótica do cuidar, mas também na perspectiva do desenvolvimento da profissão.La presente es una Investigacíon de campo, descriptiva-exploratoria con enfoque cualitativo, realizada en 2009, cuyo objetivo fue conocer la percepción del enfermero (a ante el niño con cáncer en cuidados paliativos; debatir cómo esta percepción del enfermero afecta los cuidados prestados al niño con cáncer en cuidados paliativos. Los sujetos del estudio fueron cinco enfermeros de la sección de pediatría del HEMORIO, y la interpretación del discurso se dió através del análisis temático . Notamos que el cuidar al niño con cáncer en cuidados paliativos es un proceso de sufrimiento y una mezcla de emociones para estos profesionales , y que los cuidados se orientan a la promoción de la comodidad, a través de alivio del dolor y de los síntomas, además de satisfacer las necesidades biopsicosociales y espirituales, y brindar apoyo a la familia. Se concluyó que es indispensable enfatizar la importancia que tiene la

  12. 6 Common Cancers - Breast Cancer

    Science.gov (United States)

    ... have revolutionized breast cancer treatment: tamoxifen (Nolvadex) and trastuzumab (Herceptin). Bernard Fisher, M.D., of the University of ... breast tumors. Dr. Slamon and his colleagues developed trastuzumab (Herceptin). Trastuzumab, a monoclonal antibody, was the first ...

  13. Cancer Surgery: Physically Removing Cancer

    Science.gov (United States)

    ... in cancer diagnosis, staging, treatment and symptom relief. Robotic surgery. In robotic surgery, the surgeon sits away from the operating table ... to maneuver surgical tools to perform the operation. Robotic surgery helps the surgeon operate in hard-to-reach ...

  14. Relative contributions of Na+/H+ exchange and Na+/HCO3- cotransport to ischemic Na-i(+) overload in isolated rat hearts

    NARCIS (Netherlands)

    Ten Hove, M; Nederhoff, MGJ; Van Echteld, CJA

    2005-01-01

    The Na+/H+ exchanger (NHE) and/or the Na+/HCO3- cotransporter (NBC) were blocked during ischemia in isolated rat hearts. Intracellular Na+ concentration ([Na+](i)), intracellular pH (pH(i)), and energy-related phosphates were measured by using simultaneous Na-23 and P-31 NMR spectroscopy. Hearts wer

  15. SEPP1 influences breast cancer risk among women with greater native american ancestry: the breast cancer health disparities study.

    Directory of Open Access Journals (Sweden)

    Andrew J Pellatt

    Full Text Available Selenoproteins are a class of proteins containing a selenocysteine residue, many of which have been shown to have redox functions, acting as antioxidants to decrease oxidative stress. Selenoproteins have previously been associated with risk of various cancers and redox-related diseases. In this study we evaluated possible associations between breast cancer risk and survival and single nucleotide polymorphisms (SNPs in the selenoprotein genes GPX1, GPX2, GPX3, GPX4, SELS, SEP15, SEPN1, SEPP1, SEPW1, TXNRD1, and TXNRD2 among Hispanic/Native American (2111 cases, 2597 controls and non-Hispanic white (NHW (1481 cases, 1586 controls women in the Breast Cancer Health Disparities Study. Adaptive Rank Truncated Product (ARTP analysis was used to determine both gene and pathway significance with these genes. The overall selenoprotein pathway PARTP was not significantly associated with breast cancer risk (PARTP = 0.69, and only one gene, GPX3, was of borderline significance for the overall population (PARTP =0.09 and marginally significant among women with 0-28% Native American (NA ancestry (PARTP=0.06. The SEPP1 gene was statistically significantly associated with breast cancer risk among women with higher NA ancestry (PARTP=0.002 and contributed to a significant pathway among those women (PARTP=0.04. GPX1, GPX3, and SELS were associated with Estrogen Receptor-/Progesterone Receptor+ status (PARTP = 0.002, 0.05, and 0.01, respectively. Four SNPs (GPX3 rs2070593, rsGPX4 rs2074451, SELS rs9874, and TXNRD1 rs17202060 significantly interacted with dietary oxidative balance score after adjustment for multiple comparisons to alter breast cancer risk. GPX4 was significantly associated with breast cancer survival among those with the highest NA ancestry (PARTP = 0.05 only. Our data suggest that SEPP1 alters breast cancer risk among women with higher levels of NA ancestry.

  16. SISTEMI IPTV NA IP MULTIMEDIJSKEM PODSISTEMU

    OpenAIRE

    2013-01-01

    Diplomsko delo obravnava arhitekture sistemov IPTV na IP multimedijskem podsistemu ter pripadajoče storitve in funkcije IPTV na IP multimedijskem podsistemu. Predstavljene arhitekture prinašajo veliko novih funkcionalnosti, ki so podrobneje predstavljene po posameznih enotah. V nalogi je tudi podrobneje opisana arhitektura IP multimedijskega podsistema z ravninami in protokoli. Naloga se zaključuje s storitvami na takšnih arhitekturah.

  17. PREZENTACIJA RAZVALIN GRADU NA PIRAMIDI V MARIBORU

    OpenAIRE

    Šegula Seršen, Pina

    2014-01-01

    Diplomsko delo podaja predlog za ohranitev ostalin razvalin gradu na Piramidi v Mariboru. V njem načrtujemo ureditev arheološkega območja Piramida ter problematiko prezentiranja izkopanin v povezavi z umestitvijo novih kulturnih in izobraževalnih funkcij. Diplomsko delo je sestavljeno iz analitičnega in projektnega dela. V prvem delu so raziskani arhitekturni, zgodovinski in kulturnovarstveni aspekti, na podlagi katerih je razvit idejni projekt, opisan v drugem delu naloge.

  18. Afatinib in Advanced Refractory Urothelial Cancer

    Science.gov (United States)

    2017-03-06

    Distal Urethral Cancer; Proximal Urethral Cancer; Recurrent Bladder Cancer; Recurrent Urethral Cancer; Stage III Bladder Cancer; Stage III Urethral Cancer; Stage IV Bladder Cancer; Stage IV Urethral Cancer; Ureter Cancer

  19. O consumo na vida digital

    Directory of Open Access Journals (Sweden)

    Iuri Yudi Furukita Baptista

    2016-02-01

    Full Text Available O modelo de consumo não possui as mesmas características sempre: suas relações, motivações, formatos, espaços, interesses e atividades são construções sociais que se modificam atreladas ao cenário econômico, político e tecnológico. O presente trabalho repassa o surgimento da sociedade do consumidor para então conjecturar sobre as propriedades distintivas do consumo na vida digital. O que se defende ao final é que o consumidor já não se restringe ao papel de consumir.

  20. NA-NET numerical analysis net

    Energy Technology Data Exchange (ETDEWEB)

    Dongarra, J. (Tennessee Univ., Knoxville, TN (United States). Dept. of Computer Science Oak Ridge National Lab., TN (United States)); Rosener, B. (Tennessee Univ., Knoxville, TN (United States). Dept. of Computer Science)

    1991-12-01

    This report describes a facility called NA-NET created to allow numerical analysts (na) an easy method of communicating with one another. The main advantage of the NA-NET is uniformity of addressing. All mail is addressed to the Internet host na-net.ornl.gov'' at Oak Ridge National Laboratory. Hence, members of the NA-NET do not need to remember complicated addresses or even where a member is currently located. As long as moving members change their e-mail address in the NA-NET everything works smoothly. The NA-NET system is currently located at Oak Ridge National Laboratory. It is running on the same machine that serves netlib. Netlib is a separate facility that distributes mathematical software via electronic mail. For more information on netlib consult, or send the one-line message send index'' to netlib{at}ornl.gov. The following report describes the current NA-NET system from both a user's perspective and from an implementation perspective. Currently, there are over 2100 members in the NA-NET. An average of 110 mail messages pass through this facility daily.

  1. NA-NET numerical analysis net

    Energy Technology Data Exchange (ETDEWEB)

    Dongarra, J. [Tennessee Univ., Knoxville, TN (United States). Dept. of Computer Science]|[Oak Ridge National Lab., TN (United States); Rosener, B. [Tennessee Univ., Knoxville, TN (United States). Dept. of Computer Science

    1991-12-01

    This report describes a facility called NA-NET created to allow numerical analysts (na) an easy method of communicating with one another. The main advantage of the NA-NET is uniformity of addressing. All mail is addressed to the Internet host ``na-net.ornl.gov`` at Oak Ridge National Laboratory. Hence, members of the NA-NET do not need to remember complicated addresses or even where a member is currently located. As long as moving members change their e-mail address in the NA-NET everything works smoothly. The NA-NET system is currently located at Oak Ridge National Laboratory. It is running on the same machine that serves netlib. Netlib is a separate facility that distributes mathematical software via electronic mail. For more information on netlib consult, or send the one-line message ``send index`` to netlib{at}ornl.gov. The following report describes the current NA-NET system from both a user`s perspective and from an implementation perspective. Currently, there are over 2100 members in the NA-NET. An average of 110 mail messages pass through this facility daily.

  2. IZGRADNJA MIKRO HIDROELEKTRARNE NA SKRBINSKEM POTOKU

    OpenAIRE

    Brezočnik, Simon

    2012-01-01

    Namen diplomske naloge je izgradnja mikro hidroelektrarne na Skrbinskem potoku. Predstavljene so splošne komponente potrebne za proizvajanje električne energije na manjšem vodotoku ˝Skrbinski˝ potok z možnostjo agregata do moči 36 kVA. Tema diplomske naloge je zanimiva, saj je nekoč visokogorska kmetija že imela manjšo postrojenje za samooskrbo domačije z električno energijo v mlinu na potoku Žavc in na potoku Radoljna, kjer je proizvajala električno energijo za potrebe žage torej za razrez ...

  3. A Biotecnologia na esfera pública

    OpenAIRE

    2007-01-01

    Este trabalho foca o envolvimento de cidadãos ligados à agricultura, à I&D agronómica e ao meio rural em assuntos de inovação na agricultura,tomando como caso de estudo ‘a biotecnologia na agricultura’ designada por agrobiotecnologia ou biotecnologia verde, na qual se incluem os organismos geneticamente modificados (‘OGM’) ou transgénicos. O seu uso na agricultura tem gerado desacordo entre os seus adeptos e os seus opositores, incluindo-se nestes dois grupos diversos actores. Pelo facto d...

  4. Fabrication of implanted $^{22}$Na targets

    CERN Multimedia

    2002-01-01

    A knowledge of the $^{22}$Na(p,$\\gamma$)$^{23}$ Mg reaction rate is of significant astrophysical interest. In order to complete previous studies of this reaction, radioactive $^{22}$Na targets of high purity are required. We ask for support to fabricate these targets via the implantation technique at ISOLDE GPS (off—line mode) using $^{22}$Na nuclides in an Al matrix produced in Nov. 1990 at the PSI (Zürich). The $^{22}$Na nuclides are released and ionized in a surface ionisation source, mass-analyzed at ISOLDE GPS, and implanted in a Ni-Ta backing and a C—foil in a special implantation setup.

  5. NaHCO3 and NaC1 tolerance in chronic renal failure.

    Science.gov (United States)

    Husted, F C; Nolph, K D; Maher, J F

    1975-08-01

    In patients with chronic renal failure, NaHCO3 therapy may correct or prevent acidemia. It has been proposed that the NaHCO3 required will not result in clinically significant Na retention comparable to that from similar increases in NaC1 intake. In each of ten patients with chronic renal failure, creatinine clearance (Ccr) range 2.5-16.8 ml/min, on an estimated 10-meq Na and C1 diet, electrolyte excretion was compared on NaHCO3 vs NaC1 supplements of 200 meq/day. Periods of NaHCO3 and NaC1 (in alternate order for successive patients) lasted 4 days, separated by reequilibration to base-line weight. Mean +/- SEM excretion (ex) of Na, C1, and HCO3 and deltaCcr and deltaweight (day 4-1) are compared below for the 4th day of NaC1 vs. NaHCO3 intake. Mean Ccr +/-SEM on day 4 of NaC1 and NaHCO3 were 10.8 +/-1.6 and 9.0 +/-1.4 ml/min, respectively (P less than 0.02). Mean systolic blood pressure (but not diastolic) increased significantly on NaC1 (P less than 0.05). No significant blood pressure changes were seen on NaHCO3. Net positive HCO3 balance occurred on NaHCO3 as indicated above and reflected a rise in mean serum HCO3 from 19 to 30 meq/liter (day 1 vs. 4) (P less than 0.01). Mechanisms for the greater excretion of Na on NaHCO3 may relate to C1 wasting as noted above on low C1 intake and limited HCO3 reabsorptive capacity. Thus, Na excretion by day 4 was greater on NaHCO3 than on NaHCO3 did Na excretion near intake (210 meq/day).

  6. Intra-Prostate Cancer Vaccine Inducer

    Science.gov (United States)

    2006-07-01

    immu- nogenicity while normal antigens are tolerated during development and are of much weaker im- munogenicity. (2) Autoimmunity induction is or...RF, Barr H, et al. Palliation of patients with dysphagia due to advanced esophageal cancer by endoscopic injection of cisplatin/epinephrine injectable...SA, McCormack NA, Lavender D, Haworth R. The assessment of local tolerance , acute toxicity, and DNA biodistribution following particle-mediated

  7. How Is Thyroid Cancer Diagnosed?

    Science.gov (United States)

    ... Cancer Early Detection, Diagnosis, and Staging Tests for Thyroid Cancer Thyroid cancer may be diagnosed after a person ... Health Care Team About Thyroid Cancer? More In Thyroid Cancer About Thyroid Cancer Causes, Risk Factors, and Prevention ...

  8. What Is Melanoma Skin Cancer?

    Science.gov (United States)

    ... Skin Cancer About Melanoma Skin Cancer What Is Melanoma Skin Cancer? Cancer starts when cells in the ... pigment, causing the skin to tan or darken. Melanoma skin cancers Melanoma is a cancer that begins ...

  9. How Is Stomach Cancer Diagnosed?

    Science.gov (United States)

    ... Cancer Early Detection, Diagnosis, and Staging How Is Stomach Cancer Diagnosed? Stomach cancers are usually found when a ... Ask Your Doctor About Stomach Cancer? More In Stomach Cancer About Stomach Cancer Causes, Risk Factors, and Prevention ...

  10. Key Statistics for Thyroid Cancer

    Science.gov (United States)

    ... and Treatment? Thyroid Cancer About Thyroid Cancer Key Statistics for Thyroid Cancer How common is thyroid cancer? ... remains very low compared with most other cancers. Statistics on survival rates for thyroid cancer are discussed ...

  11. How Is Ovarian Cancer Diagnosed?

    Science.gov (United States)

    ... Cancer Early Detection, Diagnosis, and Staging How Is Ovarian Cancer Diagnosed? If you have symptoms of ovarian cancer ... Ask Your Doctor About Ovarian Cancer? More In Ovarian Cancer About Ovarian Cancer Causes, Risk Factors, and Prevention ...

  12. Radiation Therapy for Testicular Cancer

    Science.gov (United States)

    ... Testicular Cancer Treating Testicular Cancer Radiation Therapy for Testicular Cancer Radiation therapy uses a beam of high-energy ... Testicular Cancer, by Type and Stage More In Testicular Cancer About Testicular Cancer Causes, Risk Factors, and Prevention ...

  13. NaNog: A pluripotency homeobox (master) molecule.

    Science.gov (United States)

    Allouba, Mona H; ElGuindy, Ahmed M; Krishnamoorthy, Navaneethakrishnan; Yacoub, Magdi H; Aguib, Yasmine E

    2015-01-01

    One of the most intriguing aspects of cell biology is the state of pluripotency, where the cell is capable of self-renewal for as many times as deemed "necessary", then at a specified time can differentiate into any type of cell. This fundamental process is required during organogenesis in foetal life and importantly during tissue repair in health and disease. Pluripotency is very tightly regulated, as any dysregulation can result in congenital defects, inability to repair damage, or cancer. Fuelled by the relatively recent interest in stem cell biology and tissue regeneration, the molecules implicated in regulating pluripotency have been the subject of extensive research. One of the important molecules involved in pluripotency, is NaNog, the subject of this article.

  14. Interaction between Na+/K+-pump and Na+/Ca2+-exchanger modulates intercellular communication

    DEFF Research Database (Denmark)

    Matchkov, Vladimir; Gustafsson, Helena; Rahman, Awahan;

    2007-01-01

    of Na(+)/K(+)-pump activity by removal of extracellular potassium ([K(+)](o)) also uncoupled cells, but only after inhibition of K(ATP) channels. Inhibition of the Na(+)/Ca(2+)-exchange activity by SEA0400 or by a reduction of the equilibrium potential (making it more negative) also uncoupled the cells....... Depletion of intracellular Na(+) and clamping of [Ca(2+)](i) at low concentrations prevented the uncoupling. The experiments suggest that the Na(+)/K(+)-pump may affect gap junction conductivity via localized changes in [Ca(2+)](i) through modulation of Na(+)/Ca(2+)-exchanger activity.......Ouabain, a specific inhibitor of the Na(+)/K(+)-pump, has previously been shown to interfere with intercellular communication. Here we test the hypothesis that the communication between vascular smooth muscle cells is regulated through an interaction between the Na(+)/K(+)-pump and the Na(+)/Ca(2...

  15. [Gastrointestinal cancer].

    Science.gov (United States)

    Takahashi, Yutaka

    2004-08-01

    Although their sensitivity is not high, SCC, TPA and IAP are useful for esophageal cancer. The sensitivity of CEA, CA 19-9, is relatively high, especially in well-differentiated adenocarcinoma of gastric cancer with lymph node metastasis. AFP is specific to liver metastasis from gastric cancer, and CA 125 is also specific to peritoneal dissemination. CA 72-4 and NCC-ST-439 are useful markers for advanced staging. CEA, CA 19-9, is useful for colon cancer, especially for predicting preoperative staging. Half-life and doubling time of tumor markers is useful in some cases for the evaluation of operation and chemotherapy. We showed our data concerning postoperative CEA and/or CA 19-9 monitoring after operation for gastric cancer in 120 recurrent patients. Positivities of CEA and CA 19-9 for recurrence were 65.8% and 85.0%, respectively, both of which were significantly higher than the preoperative sensitivities (28.3% and 45.0%, respectively). In most patients with high levels of preoperative CEA and/or CA 19-9, these tumor markers increased again at recurrence. Recurrent diseases were detected between 5 months after detection by diagnostic imagings and 12 months before detection by diagnostic imagings (mean of 3.1+/-3.6 months before detection by diagnostic imagings) and between 10 months after detection by diagnostic imagings and 13 months before detection by diagnostic imagings (mean 2.2+/-3.9 months before detection by diagnostic imagings) by CEA and CA 19-9 monitorings, respectively. These results suggest that CEA and/or CA 19-9 monitoring after operation was useful to predict the recurrence of gastric cancer, especially in almost all the patients with high preoperative levels of these markers.

  16. Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease

    DEFF Research Database (Denmark)

    Toustrup-Jensen, Mads Schak; Einholm, Anja P.; Schack, Vivien;

    2014-01-01

    The neurological disorders familial hemiplegic migraine type 2 (FHM2), alternating hemiplegia of childhood (AHC), and rapid-onset dystonia parkinsonism (RDP) are caused by mutations of Na+,K+-ATPase α2- and α3-isoforms, expressed in glial and neuronal cells, respectively. Although these disorders...... are distinct, they overlap in phenotypical presentation. Two Na+,K+-ATPase mutations, extending the C-terminus by either 28 residues ("+28" mutation) or an extra tyrosine ("+Y"), are associated with FHM2 and RDP, respectively. We describe here functional consequences of these and other neurological disease......, addressing the question to what extent they cause a change of the intracellular Na+ and K+ concentrations ([Na+]i and [K+]i) in COS cells. C-terminal extension mutants generally showed dramatically reduced Na+ affinity without disturbance of K+ binding, as did other RDP mutants. No phosphorylation from ATP...

  17. Lanthanide-doped NaScF4 nanoprobes: crystal structure, optical spectroscopy and biodetection

    Science.gov (United States)

    Ai, Yu; Tu, Datao; Zheng, Wei; Liu, Yongsheng; Kong, Jintao; Hu, Ping; Chen, Zhuo; Huang, Mingdong; Chen, Xueyuan

    2013-06-01

    Trivalent lanthanide ions (Ln3+)-doped inorganic nanoparticles (NPs) as potential luminescent bioprobes have been attracting tremendous interest because of their unique upconversion (UC) and downconversion (DC) luminescence properties. NaScF4, as an important host material, has been rarely reported and its crystal structure remains unclear. Herein, based on the single crystal X-ray diffraction, the space group of NaScF4 crystals was determined to be P31 containing multiple sites of Sc3+ with crystallographic site symmetry of C1, which was verified by high-resolution photoluminescence spectroscopy of Eu3+ at low temperature (10 K). Furthermore, monodisperse and size-controllable NaScF4:Ln3+ NPs were synthesized via a facile thermal decomposition method. The biotinylated NaScF4:Er3+/Yb3+ NPs were demonstrated for their applications as a heterogeneous UC luminescence bioprobe to detect avidin with a detection limit of 180 pM. After bioconjugation with amino-terminal fragment (ATF) of urokinase plasminogen activator (uPA), NaScF4:Ln3+ NPs also exhibited specific recognition of cancer cells overexpressed with uPA receptor (uPAR, an important marker of tumor biology and metastasis), showing great potentials in tumor-targeted bioimaging.Trivalent lanthanide ions (Ln3+)-doped inorganic nanoparticles (NPs) as potential luminescent bioprobes have been attracting tremendous interest because of their unique upconversion (UC) and downconversion (DC) luminescence properties. NaScF4, as an important host material, has been rarely reported and its crystal structure remains unclear. Herein, based on the single crystal X-ray diffraction, the space group of NaScF4 crystals was determined to be P31 containing multiple sites of Sc3+ with crystallographic site symmetry of C1, which was verified by high-resolution photoluminescence spectroscopy of Eu3+ at low temperature (10 K). Furthermore, monodisperse and size-controllable NaScF4:Ln3+ NPs were synthesized via a facile thermal

  18. Cancer cachexia

    Directory of Open Access Journals (Sweden)

    Kunze Philipp

    2003-11-01

    Full Text Available Abstract In recent years many efforts of researchers and clinicians were made to improve our knowledge of cachexia syndrome. Not only cancer, but also many chronic or end-stage diseases such as AIDS, chronic obstructive pulmonary disease (COPD, rheumatoid arthritis, tuberculosis and Crohn's disease are associated with cachexia, a condition of abnormally low weight, weakness, and general bodily decline which deteriorates quality of life and reduces the prognosis of the patients who suffer from it. In the present editorial we will focus cachexia related on cancer and provide some insight into this prognosis-limiting syndrome.

  19. [Cervix cancer].

    Science.gov (United States)

    Pointreau, Y; Ruffier Loubière, A; Denis, F; Barillot, I

    2010-11-01

    Cervix cancers declined in most developed countries in recent years, but remain, the third worldwide leading cause of cancer death in women. A precise staging, based on clinical exam, an abdominal and pelvic MRI, a possible PET-CT and a possible lymph node sampling is necessary to adapt the best therapeutic strategy. In France, the treatments of tumors of less than 4 cm without nodal involvement are often based on radiotherapy followed by surgery and, whereas tumors larger than 4 cm and involved nodes are treated with concurrent chemoradiotherapy. Based on an illustrated clinical case, indications, delineation, dosimetry and complications expected with radiotherapy are demonstrated.

  20. Cancer immunology

    Energy Technology Data Exchange (ETDEWEB)

    Herberman, R.B. (Univ. of Pittsburgh, Pittsburgh, PA (US))

    1986-01-01

    This book contains seven chapters. They are: Immunlogy of human T-cell leukemia/lymphonma (lymphotropic) viruses (the HTLV 'family'); Tumor specific antigens induced by mutagens and DNA hypomethylating agents: implications for the immunobiology of neoplasia; Destruction of tumor cells by macrophages: mechanisms of recognition and lysis and their regulation; Mechanisms of NK-cell mediated cytotoxicity; Role of natural killer (NK) cells in the control of tumor growth and metastatic spread; Monoclonal antibody therapy of cancer; preclinical models and investigations in humans; and Abnormalities in interleukin 2 production and response in cancer and possible therapeutic approaches.

  1. Penile Cancer

    Science.gov (United States)

    Clark, Peter E.; Spiess, Philippe E.; Agarwal, Neeraj; Biagioli, Matthew C.; Eisenberger, Mario A.; Greenberg, Richard E.; Herr, Harry W.; Inman, Brant A.; Kuban, Deborah A.; Kuzel, Timothy M.; Lele, Subodh M.; Michalski, Jeff; Pagliaro, Lance; Pal, Sumanta K.; Patterson, Anthony; Plimack, Elizabeth R.; Pohar, Kamal S.; Porter, Michael P.; Richie, Jerome P.; Sexton, Wade J.; Shipley, William U.; Small, Eric J.; Trump, Donald L.; Wile, Geoffrey; Wilson, Timothy G.; Dwyer, Mary; Ho, Maria

    2014-01-01

    Squamous cell carcinoma of the penis represents approximately 0.5% of all cancers among men in the United States and other developed countries. Although rare, it is associated with significant disfigurement, and only half of the patients survive beyond 5 years. Proper evaluation of both the primary lesion and lymph nodes is critical, because nodal involvement is the most important factor of survival. The NCCN Clinical Practice Guidelines in Oncology for Penile Cancer provide recommendations on the diagnosis and management of this devastating disease based on evidence and expert consensus. PMID:23667209

  2. A review of the infection-associated cancers in North African countries.

    Science.gov (United States)

    Hussein, Wafaa Mohamed; Anwar, Wagida A; Attaleb, Mohammed; Mazini, Loubna; Försti, Asta; Trimbitas, Roxana-Delia; Khyatti, Meriem

    2016-01-01

    Cancer is typically classified as a leading non-communicable disease; however, infectious agents, such as Helicobacter pylori (H. pylori), hepatitis B virus (HBV), hepatitis C virus (HCV) and human papilloma virus (HPV), contribute significantly to the pathogenesis of various cancers. Less developed countries, including countries of the North African (NA) region, endure the highest burden of infection-related cancers. The five most common infection-associated cancers in NA in order of incidence are bladder cancer, cervical cancer, liver cancer, stomach cancer, and nasopharyngeal carcinoma. This review aims to outline the epidemiologic pattern of infection-associated cancers in five NA countries (namely: Morocco, Algeria, Tunisia, Libya and Egypt) highlighting the similarities and differences across the region. The present study employed an initial literature review of peer-reviewed articles selected from PubMed, ScienceDirect and World Health Organization (WHO) databases based on key word searches without restriction on publication dates. Original research articles and reports written in French, as well as data from institutional reports and regional meeting abstracts were also included in this extensive review. Egypt, Libya, Tunisia, Algeria and Morocco were selected to be the focus of this review.

  3. Detección precoz de cáncer de cérvix según los discursos de las matronas de atención primaria en Segovia, España Detecção precoce de câncer cervical segundo discursos de parteiras na atenção primária em Segóvia, Espanha Early detection of cervical cancer according to the discourses of primary care midwives in Segovia, Spain

    Directory of Open Access Journals (Sweden)

    Laura Otero

    2011-10-01

    realizado em Segóvia, em uma área de baixa densidade populacional na Espanha, com alta proporção de populações rurais e imigrantes, de 2008 a 2009. Utilizou-se a entrevista semi-estruturada para coleta de informações. Foram entrevistadas dez parteiras das 16 Zonas Básicas de Saúde. A análise da informação baseou-se nas propostas da Teoria Fundamentada. ANÁLISE DOS RESULTADOS: O acesso e utilização do Programa Preventivo de Câncer Cervical relacionam-se a mulheres atendidas pela parteira, as vivências das mulheres em relação os resultados do exame de citologia vaginal e sua percepção de risco de sofrer um câncer de colo uterino. A barreira percebida é a distância para comparecer à consulta com a parteira. Para as mulheres imigrantes há ainda a possibilidade de não dispor de carteira de saúde e desconhecer o programa. A exclusão social também está relacionada a barreiras de acesso e utilização. O principal facilitador identificado foi o aconselhamento dos médicos de família para participar do programa. CONCLUSÕES: As parteiras percebem desigualdades de acesso e utilização do Programa Preventivo de Câncer Cervical que se relacionam tanto com características individuais das mulheres como com o meio geográfico em que vivem e com a própria estrutura do Programa. Há situações de vulnerabilidade da eqüidade de grupos de mulheres pouco representadas em nível de inquéritos populacionais, como as imigrantes e as que moram em zonas rurais.OBJECTIVE: To analyze the discourses of primary care midwives on access to and utilization of the Cervical Cancer Prevention Program. METHODS: A qualitative study was conducted in an area of low population density with a high proportion of rural population in Segovia, Spain, between 2008 and 2009. Semi-structured interviews were carried out. Ten primary care midwives were interviewed covering the 16 basic health districts of the city. Data analysis was based on grounded theory methodology. RESULTS

  4. Chemotherapeutic Targeting of Fibulin-5 to Suppress Breast Cancer Invasion and Metastasis Simulated by Transforming Growth Factor-Beta

    Science.gov (United States)

    2012-01-01

    rates in patients with cancers of the brain , breast, lung, and blood. Our findings related to this novel FBLN5:fibromodulin signaling axis were...epithelial cells via a MMP-dependent mechanism. Carcinogenesis, 29, 2243-2251. [2] Bhowmick NA and Moses HL (2005). Tumor-stroma interactions. Curr...Opin Genet Dev, 15, 97- 101. 13 [3] Bhowmick NA, Neilson EG and Moses HL (2004). Stromal fibroblasts in cancer initiation and progression. Nature

  5. Nitric oxide and pH modulation in gynaecological cancer.

    Science.gov (United States)

    Sanhueza, Carlos; Araos, Joaquín; Naranjo, Luciano; Barros, Eric; Subiabre, Mario; Toledo, Fernando; Gutiérrez, Jaime; Chiarello, Delia I; Pardo, Fabián; Leiva, Andrea; Sobrevia, Luis

    2016-12-01

    Nitric oxide plays several roles in cellular physiology, including control of the vascular tone and defence against pathogen infection. Neuronal, inducible and endothelial nitric oxide synthase (NOS) isoforms synthesize nitric oxide. Cells generate acid and base equivalents, whose physiological intracellular concentrations are kept due to membrane transport systems, including Na(+) /H(+) exchangers and Na(+) /HCO3(-) transporters, thus maintaining a physiological pH at the intracellular (~7.0) and extracellular (~7.4) medium. In several pathologies, including cancer, cells are exposed to an extracellular acidic microenvironment, and the role for these membrane transport mechanisms in this phenomenon is likely. As altered NOS expression and activity is seen in cancer cells and because this gas promotes a glycolytic phenotype leading to extracellular acidosis in gynaecological cancer cells, a pro-inflammatory microenvironment increasing inducible NOS expression in this cell type is feasible. However, whether abnormal control of intracellular and extracellular pH by cancer cells regards with their ability to synthesize or respond to nitric oxide is unknown. We, here, discuss a potential link between pH alterations, pH controlling membrane transport systems and NOS function. We propose a potential association between inducible NOS induction and Na(+) /H(+) exchanger expression and activity in human ovary cancer. A potentiation between nitric oxide generation and the maintenance of a low extracellular pH (i.e. acidic) is proposed to establish a sequence of events in ovarian cancer cells, thus preserving a pro-proliferative acidic tumour extracellular microenvironment. We suggest that pharmacological therapeutic targeting of Na(+) /H(+) exchangers and inducible NOS may have benefits in human epithelial ovarian cancer.

  6. Inelastic processes in Na+-Ne, Na+-Ar, Ne+-Na, and Ar+-Na collisions in the energy range 0.5-14 keV

    Science.gov (United States)

    Lomsadze, R. A.; Gochitashvili, M. R.; Kezerashvili, R. Ya.

    2015-12-01

    Absolute cross sections for charge-exchange, ionization, and excitation in Na+-Ne and Na+-Ar collisions were measured in the ion energy range 0.5 -10 keV using a refined version of a capacitor method and collision and optical spectroscopy methods simultaneously in the same experimental setup. Ionization cross sections for Ne+-Na and Ar+-Na collisions are measured at energies of 2 -14 keV using a crossed-beam spectroscopy method. The experimental data and the schematic correlation diagrams are used to analyze and determine the mechanisms for these processes. For the charge-exchange process in Na+-Ar collisions two nonadiabatic regions are revealed and mechanisms responsible for these regions are explained. Structural peculiarity on the excitation function for the resonance lines of argon atoms in Na+-Ar collisions are observed and the possible mechanisms of this phenomenon are explored. The measured ionization cross sections for Na+-Ne and Ne+-Na collisions in conjunction with the Landau-Zener formula are used to determine the coupling matrix element and transition probability in a region of pseudocrossing of the potential curves.

  7. Bullying na Escola: um sofrimento

    Directory of Open Access Journals (Sweden)

    Marlene Silva Sardinha Gurpilhares

    2014-07-01

    Full Text Available O bullying é uma forma de violência presente nas escolas e o termo é utilizado para caracterizar todas as formas de agressões repetitivas psicológicas e físicas, direta ou indiretamente. Esta violência causa sofrimentos, intimidação e medo, sempre numa relação de poder entre pares. Esta pesquisa trata de um estudo do bullying escolar: o que é, como surgiu, como identificá-lo e sua caracterização, conseqüências, causas, o papel da escola, de professores e pais e uma proposta prática que pode ser adotada para sua prevenção e contenção. O objetivo é organizar materiais para leitura dos atores educacionais para uma possível reflexão, através de pesquisas bibliográficas. Esta violência é grave e deveria ser tratada como saúde pública, devido às conseqüências que traz, como queda na aprendizagem, na autoestima e em casos mais graves, até o suicido e outras tragédias. A escola necessita atentar para esse tipo de violência, revendo suas ações em todos os momentos, tendo um olhar integral e diferenciado em relação aos alunos. É fundamental que o bullying não seja tratado como brincadeira de criança e para ser identificado e combatido é necessária uma ação entre a família e todos da escola, que pode ser desenvolvida através de projetos que ajudem a apontar caminhos para a solução do problema. Tais ações devem ser pautadas por constantes debates e reflexões, nas quais o aluno se torne o protagonista. Não existem fórmulas prontas, pois a intervenção deve ser feita através da realidade de cada escola.

  8. Prostate cancer is not breast cancer

    Directory of Open Access Journals (Sweden)

    Ajit Venniyoor

    2016-01-01

    Full Text Available Cancers of the prostate and breast are hormone dependent cancers. There is a tendency to equate them and apply same algorithms for treatment. It is pointed out that metastatic prostate cancer with bone-only disease is a potentially fatal condition with a much poorer prognosis than metastatic breast cancer and needs a more aggressive approach.

  9. Negative electrodes for Na-ion batteries.

    Science.gov (United States)

    Dahbi, Mouad; Yabuuchi, Naoaki; Kubota, Kei; Tokiwa, Kazuyasu; Komaba, Shinichi

    2014-08-07

    Research interest in Na-ion batteries has increased rapidly because of the environmental friendliness of sodium compared to lithium. Throughout this Perspective paper, we report and review recent scientific advances in the field of negative electrode materials used for Na-ion batteries. This paper sheds light on negative electrode materials for Na-ion batteries: carbonaceous materials, oxides/phosphates (as sodium insertion materials), sodium alloy/compounds and so on. These electrode materials have different reaction mechanisms for electrochemical sodiation/desodiation processes. Moreover, not only sodiation-active materials but also binders, current collectors, electrolytes and electrode/electrolyte interphase and its stabilization are essential for long cycle life Na-ion batteries. This paper also addresses the prospect of Na-ion batteries as low-cost and long-life batteries with relatively high-energy density as their potential competitive edge over the commercialized Li-ion batteries.

  10. Razvitak naselja na kvarnerskim otocima - primjer Dobrinja

    Directory of Open Access Journals (Sweden)

    Marijan Bradanović

    2012-12-01

    Full Text Available Na dosad slabo poznatom i sa stajališta povijesti umjetnosti još posve neobrađenom primjeru Dobrinja na otoku Krku, raspravlja se o razvitku naselja na kvarnerskim otocima. Uz isticanje štetnosti dosad prevladavajućih uopćavanja, karakteristični položaj i razvitak Dobrinja tumače se u širem, komparativnom kontekstu. Analiziraju se prostiranje i obilježja pojedinih dijelova ovog naselja, a naglasak je na vremenu kasnog srednjeg i ranijeg novog vijeka. Tada je najuži dio povijesnog središta Dobrinja poprimio čvrstu, na tlorisnoj osnovi i danas, usprkos opsežnim pregradnjama i arhitektonskim preinakama, jasno uočljivu, urbanu fizionomiju.

  11. Kidney Cancer

    Science.gov (United States)

    You have two kidneys. They are fist-sized organs on either side of your backbone above your waist. The tubes inside filter and ... blood, taking out waste products and making urine. Kidney cancer forms in the lining of tiny tubes ...

  12. Colon Cancer

    Centers for Disease Control (CDC) Podcasts

    2013-11-05

    In this podcast, Dr. Tom Frieden, CDC Director, discusses colon cancer and the importance of early detection.  Created: 11/5/2013 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 3/6/2014.

  13. Breast cancer

    Science.gov (United States)

    ... women: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med . 2014;160:271-281. PMID: 24366376 www.ncbi. ... Cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med . [Epub ahead of print 12 January 2016] doi: ...

  14. Esophageal cancer

    DEFF Research Database (Denmark)

    Mortensen, M. B.

    2007-01-01

    The distribution of adenocarcinomas and squamous cell carcinomas in esophageal cancer (EC) has changed, and focus directed towards tumors of the distal esophagus and the esophagogastric junction. The genetic events leading to EC are not fully clarified, but important risk factors have been...

  15. Lung cancer

    DEFF Research Database (Denmark)

    Hansen, H H; Rørth, M

    1999-01-01

    The results of the many clinical trials published in 1997 had only modest impact on the treatment results using either cytostatic agents alone or combined with radiotherapy in lung cancer. In SCLC, combination chemotherapy including platin-compounds (cisplatin, carboplatin) and the podophyllotoxins...

  16. Genomic and transcriptomic plasticity in treatment-naive ovarian cancer

    NARCIS (Netherlands)

    Hoogstraat, Marlous; de Pagter, Mirjam S; Cirkel, Geert A; van Roosmalen, Markus J; Harkins, Timothy T; Duran, Karen; Kreeftmeijer, Jennifer; Renkens, Ivo; Witteveen, Petronella O; Lee, Clarence C; Nijman, Isaac J; Guy, Tanisha; van 't Slot, Ruben; Jonges, Trudy N; Lolkema, Martijn P; Koudijs, Marco J; Zweemer, Ronald P; Voest, Emile E; Cuppen, Edwin; Kloosterman, Wigard P

    2014-01-01

    Intra-tumor heterogeneity is a hallmark of many cancers and may lead to therapy resistance or interfere with personalized treatment strategies. Here, we combined topographic mapping of somatic breakpoints and transcriptional profiling to probe intra-tumor heterogeneity of treatment-naïve stage IIIC/

  17. Curcumin Attenuates Gastric Cancer Induced by N-Methyl-N-Nitrosourea and Saturated Sodium Chloride in Rats

    Directory of Open Access Journals (Sweden)

    Kawiya Sintara

    2012-01-01

    Full Text Available To determine effects of curcumin on N-methyl-N-nitrosourea (MNU and saturated sodium chloride (s-NaCl-induced gastric cancer in rats. Male Wistar rats were divided into 5 groups: control (CO, control supplemented with 200 mg/kg curcumin (CC, MNU + s-NaCl, MNU + s-NaCl supplemented with 200 mg/kg curcumin daily for the first 3 weeks (MNU + s-NaCl + C3W, and MNU + s-NaCl supplemented with curcumin for 20 weeks (MNU + s-NaCl + C20W. To induce stomach cancer, rats except for CO and CC were orally treated with 100 mg/kg MNU on day 0 and 14, and s-NaCl twice-a-week for the first 3 weeks. The experiment was finished and rats were sacrificed at the end of 20 weeks. Cancers were found in forestomachs of all rats in MNU + s-NaCl. The expressions of phosphorylated inhibitor kappaB alpha (phospho-IκBα, 8-hydroxy-2′-deoxyguanosine (8-OHdG, and cyclin D1 significantly increased in MNU + s-NaCl compared with CO. Curcumin treatments for 3 and 20 weeks reduced the cancer incidence resulting in a decrease of phospho-IκBα expression in benign tumor-bearing rats compared with MNU + s-NaCl. Curcumin treatment for 20 weeks also decreased 8-OHdG expression in benign tumor-bearing rats compared with MNU + s-NaCl. Curcumin can attenuate cancer via a reduction of phospho-IκBα and 8-OHdG expressions, which may play a promising role in gastric carcinogenesis.

  18. Curcumin attenuates gastric cancer induced by N-methyl-N-nitrosourea and saturated sodium chloride in rats.

    Science.gov (United States)

    Sintara, Kawiya; Thong-Ngam, Duangporn; Patumraj, Suthiluk; Klaikeaw, Naruemon

    2012-01-01

    To determine effects of curcumin on N-methyl-N-nitrosourea (MNU) and saturated sodium chloride (s-NaCl)-induced gastric cancer in rats. Male Wistar rats were divided into 5 groups: control (CO), control supplemented with 200 mg/kg curcumin (CC), MNU + s-NaCl, MNU + s-NaCl supplemented with 200 mg/kg curcumin daily for the first 3 weeks (MNU + s-NaCl + C3W), and MNU + s-NaCl supplemented with curcumin for 20 weeks (MNU + s-NaCl + C20W). To induce stomach cancer, rats except for CO and CC were orally treated with 100 mg/kg MNU on day 0 and 14, and s-NaCl twice-a-week for the first 3 weeks. The experiment was finished and rats were sacrificed at the end of 20 weeks. Cancers were found in forestomachs of all rats in MNU + s-NaCl. The expressions of phosphorylated inhibitor kappaB alpha (phospho-IκBα), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and cyclin D1 significantly increased in MNU + s-NaCl compared with CO. Curcumin treatments for 3 and 20 weeks reduced the cancer incidence resulting in a decrease of phospho-IκBα expression in benign tumor-bearing rats compared with MNU + s-NaCl. Curcumin treatment for 20 weeks also decreased 8-OHdG expression in benign tumor-bearing rats compared with MNU + s-NaCl. Curcumin can attenuate cancer via a reduction of phospho-IκBα and 8-OHdG expressions, which may play a promising role in gastric carcinogenesis.

  19. Barroco: A tempestade na Biblioteca

    Directory of Open Access Journals (Sweden)

    Diego Cervelin

    2008-12-01

    Full Text Available Desde que Heinrich Wölfflin, nos últimos vinte anos do século XIX, se interessou por trazer à tona as formas arquitetônicas do século XVII conferindo-lhes caráter autônomo de estilo histórico determinável, não é nenhuma novidade que os estudos sobre o barroco pudessem polarizar – quase sempre em um tom colérico – os pesquisadores da arte e da cultura. Em terras do Brasil, não chega a ser de todo descabido recordar a severíssima crítica operada por Sérgio Buarque de Holanda em Raízes do Brasil. O livro, que pretende detectar a avalanche de equívocos que teria povoado o passado nacional com as vistas voltadas para a concretização de um projeto de emancipação e progresso na linha da história brasileira, apresenta em seu quarto capítulo uma impugnação explícita ao passado colonial.

  20. Terapia de linguagem na afasia

    Directory of Open Access Journals (Sweden)

    Mauro Spinelli

    1977-12-01

    Full Text Available A terapia da linguagem na afasia foi estudada em 15 pacientes, 8 do sexo masculino e 7 do sexo feminino; a idade variou de menos de 10 anos a mais de 50 anos; em 11 casos a afasia era sequela de acidente vascular cerebral e, em 4, de traumatismo crânio-encefálico. Quanto ao tipo de afasia, 5 pacientes apresentavam déficits predominantemente de expressão e 10 apresentavam déficits receptivos e expressivos em graus equiparáveis. Em 6 casos a terapia foi iniciada dentro dos 3 primeiros meses de instalação do quadro; nos restantes foi iniciada mais tardiamente. Dos 15 pacientes, 11 apresentaram evolução satisfatória, a qual não depndeu do grau de afasia, do tipo de afasia, da idade do paciente, do tipo de patologia e do intervalo entre a instalação do quadro afásico e o início da terapia. A terapia da linguagem no paciente afásico é efetiva, o prognóstico não pode ser feito a priori. Somente a evolução do caso com sua retestagem criteriosa poderá dar dados realmente úteis para se falar em evolução.

  1. Anodic Synthesis and Characterization of Na-Pb-O, Na-Pb-Bi-O Crystals

    Institute of Scientific and Technical Information of China (English)

    Li Mei QIU; Fen LIU; Liang Zhong ZHAO

    2005-01-01

    Crystals of Na-Pb-O and Na-Pb-Bi-O were electrosynthesized on the anode from molten salts. The resulting crystals have a hexagonal structure, in which the base ions (Pb and Bi) are in high oxidation states. By using KOH/NaOH (atomic ratio K:Na=1:1) mixture as a flux,incorporation of K ions into the lattice is inhibited while incorporation of Bi ions is enhanced. The magnetic measurement shows that the Na-Pb-Bi-O crystals are dominated by diamagnetism.

  2. Aponecrotic, antiangiogenic and antiproliferative effects of a novel dextran derivative on breast cancer growth in vitro and in vivo.

    Science.gov (United States)

    Di Benedetto, Mélanie; Starzec, Anna; Colombo, Bruno M; Briane, Dominique; Perret, Gérard Y; Kraemer, Michel; Crépin, Michel

    2002-04-01

    1. Since the sodium phenylacetate (NaPa) was reported to enhance the inhibitory effect of carboxymethyl benzylamide dextran (CMDB) on the breast cancer growth, we performed the esterification of CMDB with NaPa to obtain a new drug carrying the characteristics of these two components. A new molecule, phenylacetate carboxymethyl benzylamide dextran, was named NaPaC. 2. We investigated in vitro and in vivo the effects of NaPaC on MCF-7ras cell growth as well as its apoptotic and antiangiogenic effects in comparison to NaPa and CMDB. In addition, we assessed in vitro the antiproliferative effects of these drugs on other breast cancer cells, including MDA-MB-231, MDA-MB-435 and MCF-7. 3. In vitro, NaPaC inhibited MCF-7ras cell proliferation by 40% at concentration lower than that of CMDB and NaPa (12 microM vs 73 microM and 10 mM). IC(50)s were 6 and 28 microM for NaPaC and CMDB, respectively. The similar results were obtained for three other breast cancer cell lines. NaPaC reduced the DNA replication and induced cell recruitment in G(0)/G(1) phase more efficiently than its components. Moreover, it induced a cell death at concentration 1000-fold lower than NaPa. 4. In vivo, CMDB (150 mg kg(-1)) and NaPa (40 mg kg(-1)) inhibited the MCF-7ras tumour growth by 37 and 57%, respectively, whereas NaPaC (15 mg kg(-1)) decreased tumour growth by 66% without toxicity. 5. NaPa or CMDB reduced the microvessel number in tumour by 50% after 7 weeks of treatment. NaPaC had the same effect after only 2 weeks. After 7 weeks, it generated a large necrosis area without detectable microvessels. In vitro, NaPaC inhibited human endothelial cell proliferation more efficiently than CMDB or NaPa. NaPaC interacts with vascular endothelial growth factor as observed by affinity electrophoresis. 6. NaPaC acts like NaPa and CMDB but in more potent manner than components used separately. Its antiproliferative, aponecrotic and anti-angiogenic actions make it a good candidate for a new anti-cancer

  3. Sodium phenylacetate (NaPa) induces modifications of the proliferation, the adhesion and the cell cycle of tumoral epithelial breast cells.

    Science.gov (United States)

    Thibout, D; Kraemer, M; Di Benedetto, M; Saffar, L; Gattegno, L; Derbin, C; Crépin, M

    1999-01-01

    Sodium phenylacetate (NaPa), a physiological product of phenylalanine metabolism, present in micromolar concentrations in human plasma, has been shown to induce in vivo and in vitro cytostatic antiproliferative effects at millimolar concentrations. Cadherin molecules are powerful invasion suppressor molecules and the reduction of E-cadherin expression plays an important role in the invasion and metastasis of human breast cancer. In this study, we demonstrated, on one hand, that NaPa stimulated aggregation by increasing the expression of E-cadherin at the surface of breast cancer MCF-7ras cells transformed by Ha-ras oncogene and inhibited its expression in MCF-7 cells. We demonstrated that NaPa increased the formation of MCF-7ras cell aggregates and did not alter the formation of MCF-7 cell aggregates. By Northern blot, we demonstrated that the E-cadherin expression was not regulated at the transcriptional level. On the other hand, we analyzed the cell cycle of these 2 cell lines after NaPa treatment and showed that NaPa induced arrest at the G1/S phase in both MCF-7 and MCF-7ras cells. bFGF increased the growth of MCF-7 cells, but inhibited MCF-7ras cell proliferation. NaPa treatment suppressed the stimulation of MCF-7 cell proliferation and increased MCF-7ras cell growth inhibition. We have demonstrated a new target of NaPa action in blocking the cell cycle of tumor cells in G0/G1. We suggest that the anti-proliferative effect of NaPa associated to the restoration of the cadherin function in human mammary carcinoma cells indicates that NaPa could be a novel therapeutic agent in breast cancer.

  4. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Finding Health Care Services Managing Costs and Medical Information Advance Directives Using Trusted Resources Cancer Types Adolescents and Young Adults with Cancer Reports, Research, and Literature Quiz Cancers by Body Location/System Childhood Cancers Late Effects of Childhood Cancer Treatment ...

  5. Stomach (Gastric) Cancer Screening

    Science.gov (United States)

    ... Gastric Cancer Treatment Stomach Cancer Prevention Stomach Cancer Screening Research Stomach (Gastric) Cancer Screening (PDQ®)–Patient Version What is ... from the . There is no standard or routine screening test for stomach cancer. Several types of screening tests have been ...

  6. Breakup studies with {sup 23}Na

    Energy Technology Data Exchange (ETDEWEB)

    Jarvis, N.S.; Watson, D.L.; Gyapong, G.J.; Jones, C.D. [University of York, York YO1 5DD (United Kingdom); Bennett, S.J.; Freer, M.; Fulton, B.R.; Karban, O.; Murgatroyd, J.T.; Tungate, G. [University of Birmingham, Birmingham, B15 2TT (United Kingdom); Rae, W.D.M.; Smith, A.E. [University of Oxford, Oxford, OX1 3RA (United Kingdom)

    1995-05-01

    The breakup of {sup 23}Na nuclei into {sup 11}B+{sup 12}C and of {sup 24}Mg nuclei into {sup 12}C+{sup 12}C has been studied using the reactions {sup 12}C({sup 23}Na,{sup 11}B{sup 12}C){sup 12}C and {sup 12}C({sup 23}Na,{sup 12}C{sup 12}C){sup 11}B. Clear evidence was found for the breakup of the {sup 23}Na and {sup 24}Mg nuclei into the ground states of both fragments. The yieldrotect from the {sup 12}C({sup 23}Na,{sup 11}B{sub g.s.}{sup 12}C{sub g.s.}){sup 12}C{sub g.s.} reaction was concentrated in the region of excitationrotect energy in {sup 23}Na between 24 and 28 MeV and fragmented among a number of states. Therotect {sup 12}C({sup 23}Na,{sup 12}C{sub g.s.} {sup 12}C{sub g.s.)}{sup 11}B{sub g.s.} reaction was found to proceed chiefly via broad states at 22.1 and 23.9 MeV in {sup 24}Mg.

  7. Gasotransmitters: novel regulators of epithelial na(+) transport?

    Science.gov (United States)

    Althaus, Mike

    2012-01-01

    The vectorial transport of Na(+) across epithelia is crucial for the maintenance of Na(+) and water homeostasis in organs such as the kidneys, lung, or intestine. Dysregulated Na(+) transport processes are associated with various human diseases such as hypertension, the salt-wasting syndrome pseudohypoaldosteronism type 1, pulmonary edema, cystic fibrosis, or intestinal disorders, which indicate that a precise regulation of epithelial Na(+) transport is essential. Novel regulatory signaling molecules are gasotransmitters. There are currently three known gasotransmitters: nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H(2)S). These molecules are endogenously produced in mammalian cells by specific enzymes and have been shown to regulate various physiological processes. There is a growing body of evidence which indicates that gasotransmitters may also regulate Na(+) transport across epithelia. This review will summarize the available data concerning NO, CO, and H(2)S dependent regulation of epithelial Na(+) transport processes and will discuss whether or not these mediators can be considered as true physiological regulators of epithelial Na(+) transport biology.

  8. Gasotransmitters: Novel regulators of epithelial Na+ transport?

    Directory of Open Access Journals (Sweden)

    Mike eAlthaus

    2012-04-01

    Full Text Available The vectorial transport of Na+ across epithelia is crucial for the maintenance of Na+ and water homeostasis in organs such as the kidneys, lung or intestine. Dysregulated Na+ transport processes are associated with various human diseases such as hypertension, the salt-wasting syndrome pseudohypoaldosteronism type 1, pulmonary edema, cystic fibrosis or intestinal disorders, which indicate that a precise regulation of epithelial Na+ transport is essential. Novel regulatory signaling molecules are gasotransmitters. There are currently three known gasotransmitters: nitric oxide (NO, carbon monoxide (CO and hydrogen sulfide (H2S. These molecules are endogenously produced in mammalian cells by specific enzymes and have been shown to regulate various physiological processes. There is a growing body of evidence, which indicates that gasotransmitters may also regulate Na+ transport across epithelia. This review will summarize the available data concerning NO, CO and H2S dependent regulation of epithelial Na+ transport processes and will discuss whether or not these mediators can be considered as true physiological regulators of epithelial Na+ transport biology.

  9. Engagement of Patients With Advanced Cancer

    Science.gov (United States)

    2016-11-15

    End of Life; Advanced Cancer; Lung Neoplasm; Gastric Cancer; Colon Cancer; Glioblastoma Multiforme; Head and Neck Neoplasms; Rectum Cancer; Melanoma; Kidney Cancer; Prostate Cancer; Testicular Neoplasms; Liver Cancer; Cancer of Unknown Origin

  10. Biologic Therapy (Immunotherapy) for Kidney Cancer

    Science.gov (United States)

    ... Stage for Kidney Cancer Kidney Cancer Treating Kidney Cancer Biologic Therapy (Immunotherapy) for Kidney Cancer The goal of biologic therapy ... Therapy for Kidney Cancer Targeted Therapies for Kidney Cancer Biologic Therapy (Immunotherapy) for Kidney Cancer Chemotherapy for Kidney Cancer Pain ...

  11. EKSPERIMENTALNA ANALIZA VIBRACIJ NA PRALNI GRUPI

    OpenAIRE

    Kozel, Rok

    2012-01-01

    Diplomsko delo se ukvarja z vibracijami pralnega stroja. Eksperimentalno analizo smo opravili na laboratorijskem preizkuševališču, kjer je pralna grupa obešena na namenskem ogrodju. Na pralni grupi sta nameščena pospeškomera ADXL345, ki sta s serijsko SPI komunikacijo povezana z NI PXI-7841R karto. NI PXI-7841R karta je v ohišju NI PXI 1003 in je povezana z računalnikom. Pralna grupa je opremljena tudi z BLAC motorjem, s katerim operira razvojna plošča NEXYS 2. Vse skupaj nadziramo preko raču...

  12. Kornati na starim geografskim i pomorskim kartama

    OpenAIRE

    Faričić, Josip; Simičić, Zdenko

    2005-01-01

    U radu se na temelju analize kartografskih izvora analizira historijsko-geografski razvitak Kornatskih otoka, koji čine najbrojniju skupinu među hrvatskim otocima. Stare se karte koriste ponajprije kao sredstvo geografskih istraživanja, koje u nužnoj korelaciji s istovremenim povijesnim pisanim izvorima te modernim topografskim i pomorskim kartama čine osnovu za oblikovanje istraživačke platforme na kojoj se mogu graditi relevantni znanstveni rezultati. Na temelju starih karata moguće je, uz ...

  13. Nalaz tombusvirusa na vrsti Erigeron canadensis L.

    OpenAIRE

    Jeknić, Zoran; Erić, Živojin; Grbelja, Julijana

    1988-01-01

    Iz listova zaraženih primjeraka korovne biljke Erigeron canadensis L. koji su rasli na nekoliko lokaliteta u Sarajevu izoliran je virus iz skupine tombusvirusi. Identifikacija virusa izvršena je na osnovi reakcije pokusnih biljaka, analize ultratankih presjeka kroz zaraženo tkivo, morfologije i veličine virusnih čestica, te na osnovi seroloških reakcija metodom dvostruke imunodifuzije u agarskom gelu i čvrsto fazne imunoelektronske mikroskopije (SPIEM). U serološkim pokusima upotrijebljen je ...

  14. 钠钾ATP酶抑制剂通过调节DNA损伤感应复合体Mre11/Rad50/Nbs1的表达诱导肝癌HepG2细胞周期阻滞%Na+,K+-ATPase inhibitor induces cell cycle arrest in liver cancer HepG2 cells by regulating expression of DNA damage Mre11/Rad50/Nbs1 complex

    Institute of Scientific and Technical Information of China (English)

    徐忠伟; 王凤梅; 王聪聪; 单娜娜; 徐瑞成

    2016-01-01

    目的:研究钠钾ATP酶抑制剂华蟾毒配基( cinobufa-gin)对人肝癌 HepG2细胞 DNA损伤修复阻断及其发生机制。方法免疫组化分析人肝癌临床组织标本、正常肝组织中钠钾ATP酶α1亚单位的表达;以人肝癌细胞HepG2为靶细胞,实验分为对照组、5μmol · L-1华蟾毒配基作用6、12和24 h组;单细胞电泳检测 DNA双链断裂, Real time-PCR和Western blot检测损伤修复基因Mre11、Rad50、Nbs1和p53的表达变化,流式细胞术检测细胞周期。结果肝癌组织钠钾ATP酶α1亚单位表达与癌旁组织相比明显升高( P <0.05);华蟾毒配基诱导HepG2细胞DNA断裂的发生率与作用时间高度相关,作用时间延长断裂效应更加明显(P<0.05),Mre11,Nbs1,Rad50和p53表达随药物作用时间延长逐渐升高(P<0.05),流式细胞术分析细胞周期对照组S期细胞比例为(21.32±4.21)%,5μmol·L-1华蟾毒配基处理6 h 后为(33.25±5.72)%,处理12 h 后为(56.72±6.29)%,作用24 h后为(67.32±9.42)%。结论华蟾毒配基激活 Mre11/Rad50/Nbs1损伤感应复合体介导肝癌HepG2细胞周期阻滞。%Aim To explore the relationship between Mre11/Rad50/Nbs1 ( MRN ) complex focus formation and DNA double-strand breaks( DSBs) caused by cinob-ufagin in human hepatocellular carcinoma HepG2 cells. Methods The Na+,K+-ATPaseα1 subunit expression level in liver cancer tissues was detected by immunohis-tochemistry. After HepG2 cells were treated with 5μmol·L-1 cinobufagin for 6, 12 and 24 h, the drug-in-duced DSBs were assessed by single cell gel electro-phroesis ( SCGE ) , the gene transcription and protein levels of Mrel1, Nbs1, Rad50 and p53 were evaluated by Real time-PCR and Western blot. The cell cycle in parallel was analyzed by flow cytometry. Results The Na+, K+-ATPase α1 subunit expression level in liver cancer tissues was significantly increased compared with the tissue adjacent to carcinoma ( P <0. 05 ) . The 5μmol · L-1

  15. PERUBAHAN KEKERASAN DENTIN PADA SALURAN AKAR SETELAH APLIKASI NaOCl 3%, KOMBINASI NaOCl 3% - EDTA 17%, DAN NaOCl 3% - KLORHEKSIDIN 2%

    OpenAIRE

    ALFINA, RISCA

    2014-01-01

    2014 PERUBAHAN KEKERASAN DENTIN PADA SALURAN AKAR SETELAH APLIKASI NaOCl 3%, KOMBINASI NaOCl 3% - EDTA 17%, DAN NaOCl 3% - KLORHEKSIDIN 2% Risca Alfina Fakultas Kedokteran Gigi Universitas Hasanuddin ABSTRAK Latar Belakang: Beberapa larutan irigasi yang biasa digunakan saat pembersihan dan preparasi saluran akar yaitu sodium hypochlorite (NaOCl), klorheksidin, dan ethylenediaminetetraacetic acid (EDTA). Larutan irigasi tersebut berinteraks...

  16. cancers coliques

    OpenAIRE

    ali cherif, mohamed el amine; aliane, fatma

    2010-01-01

    - le cancer colique est un pathologie maligne de l'appareil digestif en plein recrudescence dont l'étiologies elle est polygénique = héréditaire et surtout le changement des habitudes alimentaires qui sont les principales causes d'apparition des polypes dont leurs dégénérescence évolue vers le cancer colique. D'après les étude faite dans notre service: - 07 cas sur oans d'étude (ig8i-i987). - 12 cas sur ians d' étude (1990-2002). Notre étude de oans (2005-2009) r...

  17. Enhanced photodynamic antitumor effect on gastric cancer by a novel photosensitive stealth liposome.

    Science.gov (United States)

    Namiki, Yoshihisa; Namiki, Tamami; Date, Masataka; Yanagihara, Kazuyoshi; Yashiro, Masakazu; Takahashi, Hiroshi

    2004-07-01

    Lipophilic photosensitizers hold potential for cancer photodynamic therapy. We sought to develop a novel photosensitive stealth liposome (PSSL) which incorporating a lipophilic photosensitizer into its lipid bilayer and to examine its photoactivity. We prepared PSSL composed of lipophilic chlorin e6 (Ce6) ester, dilauroylphosphatidylcholine, dioleoylphosphatidylethanolamine and distearoyl-phosphoethanolamine-N-[poly (ethylene glycol) 2000] and evaluated its photodynamic effect against gastric cancer cell lines and tumor-bearing nude mice models. In gastric cancer cell lines, LC(80) of PSSL was a maximum of 53 times as low as that of Ce6 sodium salt (Ce6-Na). PSSL completely destroyed all tumors in animal models and tumor recurrence levels were minimal (1.5 +/- 0.9%). PSSL achieved greater photodynamic effects in gastric cancer cell lines and in murine models than Ce6-Na. PSSL holds promise for photodynamic therapy for gastric cancer.

  18. 1985 Cancer Facts and Figures.

    Science.gov (United States)

    American Cancer Society, Inc., New York, NY.

    Information and statistical data about cancer are provided in seven categories. They include: (1) basic cancer data (considering how cancer works, trends in diagnosis and treatment, new cancer cases and deaths for 1985, and other areas); (2) major cancer sites (discussing lung cancer, colorectal cancer, breast cancer, 5-year survival rates/trends…

  19. How Are Childhood Cancers Found?

    Science.gov (United States)

    ... term effects of Cancer Treatment on Children References: Cancer in Children If Your Child Has Cancer Cancer in Children Finding Cancer in ... term effects of Cancer Treatment on Children References: Cancer in Children If Your Child Has Cancer Back To Top Imagine a world ...

  20. Bladder Cancer Advocacy Network

    Science.gov (United States)

    ... future bladder cancer research through the Patient Survey Network. Read More... The JPB Foundation 2016 Bladder Cancer ... 2016 Young Investigator Awardees The Bladder Cancer Advocacy Network (BCAN) has announced the recipients of the 2016 ...

  1. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Trials Information A to Z List of Cancer Drugs Complementary & Alternative Medicine (CAM) Questions to Ask about ... Types of Treatment Side Effects Clinical Trials Cancer Drugs Complementary & Alternative Medicine Coping Feelings & Cancer Adjusting to ...

  2. Cervical Cancer Stage IVA

    Science.gov (United States)

    ... historical Searches are case-insensitive Cervical Cancer Stage IVA Add to My Pictures View /Download : Small: 756x576 ... Large: 3150x2400 View Download Title: Cervical Cancer Stage IVA Description: Stage IVA cervical cancer; drawing and inset ...

  3. Cervical Cancer Screening

    Science.gov (United States)

    ... Cancer found early may be easier to treat. Cervical cancer screening is usually part of a woman's health ... may do more tests, such as a biopsy. Cervical cancer screening has risks. The results can sometimes be ...

  4. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Program Cancer Reporting Fellowships Events Scientific Meetings & Lectures Conferences Advisory Board Meetings Social Media Events Cancer Currents ... Media Contacts Multicultural Media Events Scientific Meetings & Lectures Conferences Advisory Board Meetings Social Media Cancer Currents Blog ...

  5. Ovarian Cancer FAQ

    Science.gov (United States)

    ... increased risk of breast cancer and ovarian cancer. CA 125: A substance in the blood that may increase in the presence of some cancerous tumors. Colonoscopy: An exam of the entire colon using a small, lighted instrument. Computed Tomography: A ...

  6. Coping with Cancer

    Science.gov (United States)

    ... Treatment Most people face some degree of depression, anxiety, fear or distress when cancer becomes part of their ... who has cancer. Distress in People With Cancer Anxiety, Fear, and Depression Depression Anxiety, Fear, and Emotional Distress ...

  7. Stages of Gallbladder Cancer

    Science.gov (United States)

    ... cancer. Tests that examine the gallbladder and nearby organs are used to detect (find), diagnose, and stage ... cancer cells or to make cancer cells more sensitive to the effects of radiation therapy and certain ...

  8. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... type Progress Annual Report to the Nation Cancer Portfolio Snapshots Milestones in Cancer Research & Discovery Stories of ... greatly. Also, it takes years to see the benefit of new treatments and ways of finding cancer. ...

  9. Chemotherapy for Testicular Cancer

    Science.gov (United States)

    ... Type and Stage Testicular Cancer Treating Testicular Cancer Chemotherapy for Testicular Cancer Chemotherapy (chemo) is the use of drugs to treat ... that is only in the testicle. Doctors give chemotherapy in cycles, with each period of treatment followed ...

  10. Cervical Cancer Stage IVB

    Science.gov (United States)

    ... of the body, such as the lymph nodes, lung, liver, intestine, or bone. Stage IVB cervical cancer. Topics/Categories: Anatomy -- Gynecologic Cancer Types -- Cervical Cancer Staging Type: Color, ...

  11. Liver cancer - hepatocellular carcinoma

    Science.gov (United States)

    Primary liver cell carcinoma; Tumor - liver; Cancer - liver; Hepatoma ... Hepatocellular carcinoma accounts for most liver cancers. This type of cancer occurs more often in men than women. It is usually diagnosed in people age 50 or ...

  12. Photodynamic Therapy for Cancer

    Science.gov (United States)

    ... References Dolmans DE, Fukumura D, Jain RK. Photodynamic therapy for cancer. Nature Reviews Cancer 2003; 3(5):380–387. [PubMed Abstract] Wilson BC. Photodynamic therapy for cancer: principles. Canadian Journal of Gastroenterology 2002; ...

  13. Laryngeal (Voice Box) Cancer

    Science.gov (United States)

    ... ENTCareers Marketplace Find an ENT Doctor Near You Voice Box (Laryngeal) Cancer Voice Box (Laryngeal) Cancer Patient Health Information News media ... laryngeal cancer can be severe with respect to voice, breathing, or swallowing. It is fundamentally a preventable ...

  14. Dealing with chronic cancer

    Science.gov (United States)

    ... medlineplus.gov/ency/patientinstructions/000933.htm Dealing with chronic cancer To use the sharing features on this ... be controlled for a period of time. Controlling Chronic Cancer When you have a chronic cancer, the ...

  15. Salivary Gland Cancer Treatment

    Science.gov (United States)

    ... and Oropharyngeal Cancer Screening Research Salivary Gland Cancer Treatment (PDQ®)–Patient Version General Information About Salivary Gland ... in diagnosing salivary gland cancer. Certain factors affect treatment options and prognosis (chance of recovery). The treatment ...

  16. Prostate Cancer Foundation

    Science.gov (United States)

    ... P 2 rovocative Questions PCCTC Scientific Retreat Coffey-Holden Research News Faces of Prostate Cancer [4] Survivors ... Foundation News The Prostate Cancer Foundation’s 2016 Coffey-Holden Prostate Cancer Academy Meeting accelerates advances in the ...

  17. Snapshot of Stomach Cancer

    Science.gov (United States)

    ... and vegetables. There is no standard or routine screening test for stomach cancer. Standard treatments for stomach cancer include surgery , ... NCI Stomach (Gastric) Cancer Home Page Information about stomach ... causes, screening, clinical trials, research and statistics from the National ...

  18. Oral Cancer Exam

    Medline Plus

    Full Text Available ... for signs of oral cancer. For Patients and the Public Oral Cancer Pamphlet that describes the risk factors, signs and symptoms of oral cancer, and the importance of detecting the disease in its early ...

  19. Pancreatic Cancer Risk Factors

    Science.gov (United States)

    ... risks of other cancers (or other health problems). Examples of genetic syndromes that can cause exocrine pancreatic cancer include: Hereditary breast and ovarian cancer syndrome , caused by mutations in the BRCA1 or BRCA2 genes Familial atypical ...

  20. Male Breast Cancer

    Science.gov (United States)

    ... breast cancer include exposure to radiation, a family history of breast cancer, and having high estrogen levels, which can happen with diseases like cirrhosis or Klinefelter's syndrome. Treatment for male breast cancer is usually ...

  1. Identifying cancer genes from cancer mutation profiles by cancer functions

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    It is of great importance to identify new cancer genes from the data of large scale genome screenings of gene mutations in cancers. Considering the alternations of some essential functions are indispensable for oncogenesis, we define them as cancer functions and select, as their approximations, a group of detailed functions in GO (Gene Ontology) highly enriched with known cancer genes. To evaluate the efficiency of using cancer functions as features to identify cancer genes, we define, in the screened genes, the known protein kinase cancer genes as gold standard positives and the other kinase genes as gold standard negatives. The results show that cancer associated functions are more efficient in identifying cancer genes than the selection pressure feature. Furthermore, combining cancer functions with the number of non-silent mutations can generate more reliable positive predictions. Finally, with precision 0.42, we suggest a list of 46 kinase genes as candidate cancer genes which are annotated to cancer functions and carry at least 3 non-silent mutations.

  2. Perfil nutricional na artrite reumatoide

    Directory of Open Access Journals (Sweden)

    Rachel Simone Maccarini Zarpellon

    2014-01-01

    Full Text Available Objetivo: Estudar o perfil nutricional de pacientes com artrite reumatoide (AR. Métodos: Estudo transversal observacional de 102 pacientes com AR. Os pacientes foram estudados para dados clínicos, demográficos, sorológicos, atividade de doença e perfil nutricional. Neste último incluiu-se a medida do índice de massa corporal (IMC, relação quadril/cintura, pregas cutâneas bicipitais (PCB e sua adequação; prega cutânea tricipital (PCT e sua adequação e circunferência muscular do braço (CMB e sua adequação. Estudos de associação foram feitos usando os testes de Fisher e qui-quadrado para dados nominais e teste t não pareado e Mann Whitney para dados numéricos. Para cálculo de correlação usou-se o teste de Spearman. Resultado: Na amostra existiam 14/102 homens e 88/102 mulheres com idade média de 52,1 ± 11,5 anos e duração média de doença de 10,6 ± 7,4 anos. A relação cintura/quadril média era de 0,92 ± 0,07. De acordo com IMC, 30,3% tinham peso normal e 65,5% tinham peso acima do normal. De acordo com PCB, 74,5% eram normais e 25,5% tinham depleção; de acordo com a PCT, 83,3% eram normais e 16,7% tinham depleção. Associação de variáveis nutricionais com gênero, fator reumatoide, nódulos e atividade da doença não mostraram diferenças (p = NS exceto, por uma relação cintura/quadril menor em indivíduos com nódulos (p = 0,02 e uma correlação modesta da PCT com a duração de doença (p = 0,02; R = 0,22; 95% IC = 0,01-0,40. Conclusão: Existe uma alta prevalência de sobrepeso e obesidade em artrite reumatoide e uma pequena frequência de depleção muscular.

  3. Genetic variants in interleukin genes are associated with breast cancer risk and survival in a genetically admixed population: the Breast Cancer Health Disparities Study.

    Science.gov (United States)

    Slattery, Martha L; Herrick, Jennifer S; Torres-Mejia, Gabriella; John, Esther M; Giuliano, Anna R; Hines, Lisa M; Stern, Mariana C; Baumgartner, Kathy B; Presson, Angela P; Wolff, Roger K

    2014-08-01

    Interleukins (ILs) are key regulators of immune response. Genetic variation in IL genes may influence breast cancer risk and mortality given their role in cell growth, angiogenesis and regulation of inflammatory process. We examined 16 IL genes with breast cancer risk and mortality in an admixed population of Hispanic/Native American (NA) (2111 cases and 2597 controls) and non-Hispanic white (NHW) (1481 cases and 1585 controls) women. Adaptive Rank Truncated Product (ARTP) analysis was conducted to determine gene significance and lasso (least absolute shrinkage and selection operator) was used to identify potential gene by gene and gene by lifestyle interactions. The pathway was statistically significant for breast cancer risk overall (P ARTP = 0.0006), for women with low NA ancestry (P(ARTP) = 0.01), for premenopausal women (P(ARTP) = 0.02), for estrogen receptor (ER)+/progesterone receptor (PR)+ tumors (P(ARTP) = 0.03) and ER-/PR- tumors (P(ARTP) = 0.02). Eight of the 16 genes evaluated were associated with breast cancer risk (IL1A, IL1B, IL1RN, IL2, IL2RA, IL4, IL6 and IL10); four genes were associated with breast cancer risk among women with low NA ancestry (IL1B, IL6, IL6R and IL10), two were associated with breast cancer risk among women with high NA ancestry (IL2 and IL2RA) and four genes were associated with premenopausal breast cancer risk (IL1A, IL1B, IL2 and IL3). IL4, IL6R, IL8 and IL17A were associated with breast cancer-specific mortality. We confirmed associations with several functional polymorphisms previously associated with breast cancer risk and provide support that their combined effect influences the carcinogenic process.

  4. Waardevolle lessen na overstromingen in Thailand

    NARCIS (Netherlands)

    Jonkman, S.N.; Van der Meer, M.T.; Hardeman, B.

    2012-01-01

    Een verkenningsmissie na de overstromingen in Thailand in 2011 heeft meer inzicht gegeven in het functioneren van het waterkeringssysteem tijdens de ramp. Dijken bleken kwetsbaar door overloop, evenals de aansluitingen tussen dijken en constructies.

  5. Erythrocyte 22Na+ influx in hypertension

    Energy Technology Data Exchange (ETDEWEB)

    Shalev, O.; Eaton, J.W.; Ben-Ishay, D.

    1984-01-01

    We assessed 22Na+ uptake by erythrocytes (RBC) from 38 individuals with essential hypertension and 37 healthy controls. All subjects were male, white, non-obese and with normal renal function, obviating sex, race, hormonal, ponderal and renal factors known to influence RBC Na+ handling. The mean +/- sem 22Na+ uptake of the patients was 284 +/- 16 mumole/liter RBC/hour while that of normal controls was 249 +/- 11 mumole/liter RBC/hour; although the difference reached borderline significance, individual values showed considerable overlap. Consequently, in our population, RBC 22Na+ uptake is not a reliable marker for essential hypertension. We believe that previous studies should be reassessed with regard to patients' characteristics and future studies employ rigorous criteria in selection of subjects.

  6. Aerobe zuivering van vergiste varkensdrijfmest na aanzuren

    NARCIS (Netherlands)

    Goossens, W.

    1988-01-01

    Onderzoeksverslag betreffende een vorm van nazuivering, bedoeld om de vluchtige componenten (vetzuren), die na vergisting nog aanwezig zijn, te oxideren. De mest wordt belucht onder toevoeging van zwavelzuur. Het zure milieu voorkomt ammoniakemissie tijdens het beluchten. Bovendien zullen in volgend

  7. Hydrogen-fluorine exchange in NaBH4-NaBF4.

    Science.gov (United States)

    Rude, L H; Filsø, U; D'Anna, V; Spyratou, A; Richter, B; Hino, S; Zavorotynska, O; Baricco, M; Sørby, M H; Hauback, B C; Hagemann, H; Besenbacher, F; Skibsted, J; Jensen, T R

    2013-11-07

    Hydrogen-fluorine exchange in the NaBH4-NaBF4 system is investigated using a range of experimental methods combined with DFT calculations and a possible mechanism for the reactions is proposed. Fluorine substitution is observed using in situ synchrotron radiation powder X-ray diffraction (SR-PXD) as a new Rock salt type compound with idealized composition NaBF2H2 in the temperature range T = 200 to 215 °C. Combined use of solid-state (19)F MAS NMR, FT-IR and DFT calculations supports the formation of a BF2H2(-) complex ion, reproducing the observation of a (19)F chemical shift at -144.2 ppm, which is different from that of NaBF4 at -159.2 ppm, along with the new absorption bands observed in the IR spectra. After further heating, the fluorine substituted compound becomes X-ray amorphous and decomposes to NaF at ~310 °C. This work shows that fluorine-substituted borohydrides tend to decompose to more stable compounds, e.g. NaF and BF3 or amorphous products such as closo-boranes, e.g. Na2B12H12. The NaBH4-NaBF4 composite decomposes at lower temperatures (300 °C) compared to NaBH4 (476 °C), as observed by thermogravimetric analysis. NaBH4-NaBF4 (1:0.5) preserves 30% of the hydrogen storage capacity after three hydrogen release and uptake cycles compared to 8% for NaBH4 as measured using Sievert's method under identical conditions, but more than 50% using prolonged hydrogen absorption time. The reversible hydrogen storage capacity tends to decrease possibly due to the formation of NaF and Na2B12H12. On the other hand, the additive sodium fluoride appears to facilitate hydrogen uptake, prevent foaming, phase segregation and loss of material from the sample container for samples of NaBH4-NaF.

  8. Breast cancer in pregnancy.

    Science.gov (United States)

    Krishna, Iris; Lindsay, Michael

    2013-09-01

    Pregnancy-associated breast cancer is defined as breast cancer diagnosed during pregnancy or in the first postpartum year. Breast cancer is one of the more common malignancies to occur during pregnancy and, as more women delay childbearing, the incidence of breast cancer in pregnancy is expected to increase. This article provides an overview of diagnosis, staging, and treatment of pregnancy-associated breast cancer. Recommendations for management of breast cancer in pregnancy are discussed.

  9. Living with Cancer

    Institute of Scientific and Technical Information of China (English)

    1996-01-01

    Cancer is regarded as a formidable threat to mankind. Every yem’ in Shanghai, which has a high cancer rate, 15,000 people are diagnosed with the disease and 12,000 die of cancer. Because many people believe that "cancer equals death," a special cancer rehabilitation center has appeared in Shanghai. The center creates an environment where cancer patients can exchange experiences and receive psychological group therapy. In this way those patients

  10. Cervical cancer - screening and prevention

    Science.gov (United States)

    Cancer cervix - screening; HPV - cervical cancer screening; Dysplasia - cervical cancer screening; Cervical cancer - HPV vaccine ... Almost all cervical cancers are caused by HPV (human papilloma virus). HPV is a common virus that spreads through sexual contact. Certain ...

  11. Risks of Lung Cancer Screening

    Science.gov (United States)

    ... Treatment Lung Cancer Prevention Lung Cancer Screening Research Lung Cancer Screening (PDQ®)–Patient Version What is screening? Go ... These are called diagnostic tests . General Information About Lung Cancer Key Points Lung cancer is a disease in ...

  12. Understanding a Breast Cancer Diagnosis

    Science.gov (United States)

    ... Cancer A-Z Breast Cancer Understanding a Breast Cancer Diagnosis If you’ve been diagnosed with breast cancer, ... Prevention Early Detection and Diagnosis Understanding a Breast Cancer Diagnosis Treatment Breast Reconstruction Surgery Living as a Breast ...

  13. Renal pelvis or ureter cancer

    Science.gov (United States)

    Transitional cell cancer of the renal pelvis or ureter; Kidney cancer - renal pelvis; Ureter cancer ... Cancer can grow in the urine collection system, but it is uncommon. Renal pelvis and ureter cancers ...

  14. How Is Ovarian Cancer Staged?

    Science.gov (United States)

    ... Cancer Early Detection, Diagnosis, and Staging How Is Ovarian Cancer Staged? Staging is the process of finding out ... Ask Your Doctor About Ovarian Cancer? More In Ovarian Cancer About Ovarian Cancer Causes, Risk Factors, and Prevention ...

  15. How Is Testicular Cancer Diagnosed?

    Science.gov (United States)

    ... Cancer Early Detection, Diagnosis, and Staging How Is Testicular Cancer Diagnosed? Testicular cancer is usually found as a ... the tumor might have returned. Surgery to diagnose testicular cancer Most types of cancer are diagnosed by removing ...

  16. IZDELAVA IN VODENJE AVTONOMNEGA VOZILA NA GOSENICAH

    OpenAIRE

    Obal, Aleš

    2012-01-01

    V Diplomskem delu je opisan postopek izdelave kontrolno nadzornega sistema za vodenje robota po prostoru. Ključni deli tega sistema so senzorji za merjenje orientacije in pozicije vozila na mikrokrmilniškem sistemu. Vozilu smo dodali komunikacijo z osebnim računalnikom za oddaljen nadzor in na koncu povzeli še program, ki smo ga napisali v mikroC programskem okolju.

  17. Positron-impact ionization of Na

    Energy Technology Data Exchange (ETDEWEB)

    Mukherjee, K.K. (Jawahar Navodaya Vidyalaya, Ramchandraghat, West Tripura 799207, Tripura (India)); Singh, N.R. (Thambal Marik College, Oinam, Bishanpur, Manipur (India)); Choudhury, K.B. (Department of Physics, Jadavpur University, Calcutta 700032, West Bengal (India)); Mazumdar, P.S. (Department of Physics, Manipur University, Canchipur, Imphal 795003, Manipur (India))

    1992-07-01

    In this paper we present the total cross sections for the positron-impact ionization of Na in the range 8--30 eV of the energy of the incident positron. Calculations are done by using a distorted-wave approximation incorporating the effects of screening and distortion. The present results are compared with the experimental results for the electron-impact ionization of Na.

  18. Living with Prostate Cancer

    Science.gov (United States)

    ... cancer treatment and can improve many aspects of health, including muscle strength, balance, fatigue, cardiovascular fitness, and depression. Physical activity after a prostate cancer diagnosis is linked to ...

  19. Types of Cancer Research

    Science.gov (United States)

    An infographic from the National Cancer Institute (NCI) describing the four broad categories of cancer research: basic research, clinical research, population-based research, and translational research.

  20. Colon cancer screening

    Science.gov (United States)

    Screening for colon cancer; Colonoscopy - screening; Sigmoidoscopy - screening; Virtual colonoscopy - screening; Fecal immunochemical test; Stool DNA test; sDNA test; Colorectal cancer - screening; Rectal ...

  1. Squamous cell skin cancer

    Science.gov (United States)

    ... that reflect light more, such as water, sand, concrete, and areas that are painted white. The higher ... - skin - squamous cell; Skin cancer - squamous cell; Nonmelanoma skin cancer - squamous ...

  2. Elastic Coulomb breakup of $^{34}$Na

    CERN Document Server

    Singh, G; Chatterjee, R

    2016-01-01

    Purpose : The aim of this paper is to study the elastic Coulomb breakup of $^{34}$Na on $^{208}$Pb to give us a core of $^{33}$Na with a neutron and in the process we try and investigate the one neutron separation energy and the ground state configuration of $^{34}$Na. Method : A fully quantum mechanical Coulomb breakup theory within the architecture of post-form finite range distorted wave Born approximation extended to include the effects of deformation is used to research the elastic Coulomb breakup of $^{34}$Na on $^{208}$Pb at 100 MeV/u. The triple differential cross-section calculated for the breakup is integrated over the desired components to find the total cross-section, momentum and angular distributions as well as the average momenta, along with the energy-angular distributions. Results : The total one neutron removal cross-section is calculated to test the possible ground state configurations of $^{34}$Na. The average momentum results along with energy-angular calculations indicate $^{34}$Na to ha...

  3. Expression and clinical significance of Na v1.7 and L -type calcium channel subunit α1 C in cervical cancer%Nav1.7与L-型钙离子通道在宫颈癌中的表达及临床意义

    Institute of Scientific and Technical Information of China (English)

    李慧; 王路芳; 吴爱娣; 季鑫; 武昕

    2016-01-01

    1 C in cervical cancer.Methods:Using reverse transcription -polymerase chain reaction (RT -PCR)meth-ods to detect expression of Nav 1.7 and L -type calcium channel subunit α1 C in 60 cases of cervical cancer tissue,10 cases of cervical cancer who before and after the radiation and chemotherapy group and 10 cases of normal cervical tissue.Results:The ratio of gray level of Nav 1.7 mRNA was 1.640 3 in cervical cancer,but no expression in normal cervix,in which there was significantly difference(P <0.05).The midterm expression of Nav 1.7 mRNA in high dif-ferentiation of carcinoma,differentiation of carcinoma and poorly differentiated carcinoma were 0.960 1,0.991 8 and 1.901 4,respectively,there was significantly difference(P <0.05).The midterm expression of Nav 1.7 mRNA in cervical cancer of stageⅠ -Ⅱwas 0.986 7,while in cervical cancer of stage Ⅲ -Ⅳ was 1.899 3,and the difference was statistically significant (P <0.01).Nav 1.7 was higher before radiotherapy and chemotherapy (1.4010)than that after radiochemotherapy (0.300 1)and the difference was statistically significant(P <0.01).L -type calcium chan-nel subunit α1 C mRNA in normal cervical tissues and cervical cancer tissue of the grey value of ratio were 0.091 4 and 0.357 3,respectively,there was significantly difference(P <0.05).The midterm expression of L -type calciu mchannel subunit α1 C mRNA in high differentiation of carcinoma,differentiation of carcinoma and poorly differentia-ted carcinoma were 0.291 2,0.304 5 and 0.493 5 respectively,there was significantly difference(P <0.05).The midterm expression of L -type calcium channel subunit α1C mRNA in cervical cancer of stageⅠ -Ⅱ was 0.475 4, while in cervical cancer of stage Ⅲ -Ⅳ was 0.833 7,and the difference was statistically significant (P <0.01).L -type calcium channel subunit α1 C mRNA was higher before radiotherapy and chemotherapy (0.531 6)than that after radiochemotherapy(0.102 4)and the difference was statistically significant (P

  4. Câncer na infância: análise comparativa da incidência, mortalidade e sobrevida em Goiânia (Brasil e outros países Childhood cancer: a comparative analysis of incidence, mortality, and survival in Goiania (Brazil and other countries

    Directory of Open Access Journals (Sweden)

    Patrícia Emília Braga

    2002-02-01

    Full Text Available As análises de incidência do câncer, mortalidade e sobrevida permitem identificar variações geográficas e temporais importantes para o planejamento e avaliação de ações de saúde. Neste trabalho, apresentam-se os coeficientes de incidência e de mortalidade por câncer em menores de 15 anos e suas tendências em vários países do mundo, assim como as probabilidades acumuladas de sobrevida após cinco anos do diagnóstico, em regiões desenvolvidas ou em desenvolvimento. Conclui-se que, embora em países desenvolvidos observem-se taxas crescentes ou estáveis de incidência e decrescentes de mortalidade para o câncer infantil, suas tendências são desconhecidas nos países em desenvolvimento. Nos dados de Goiânia analisados, observaram-se taxas estáveis de incidência e de mortalidade para o câncer infantil, e a sobrevida após cinco anos de diagnóstico (48% mostrou-se semelhante à de outras regiões em desenvolvimento e inferior às observadas em regiões desenvolvidas (64%-70%.Analysis of cancer incidence, mortality, and survival rates can yield geographic and temporal trends that are useful for planning and evaluating health interventions. This article reviews cancer incidence and mortality rates and respective trends around the world in children under 15 years old, as well as their 5-year survival rates in developed and developing countries. We conclude that even though increasing or stable childhood cancer incidence rates and decreasing mortality rates have been observed in developed countries, the trends remain unknown in developing countries. Data from the city of Goiania, Brazil, show stable childhood cancer incidence and mortality rates. Five-year survival rates (48% in Goiania are similar to those seen in underdeveloped regions and lower than those reported in developed countries (64-70%.

  5. Global cancer statistics, 2012.

    Science.gov (United States)

    Torre, Lindsey A; Bray, Freddie; Siegel, Rebecca L; Ferlay, Jacques; Lortet-Tieulent, Joannie; Jemal, Ahmedin

    2015-03-01

    Cancer constitutes an enormous burden on society in more and less economically developed countries alike. The occurrence of cancer is increasing because of the growth and aging of the population, as well as an increasing prevalence of established risk factors such as smoking, overweight, physical inactivity, and changing reproductive patterns associated with urbanization and economic development. Based on GLOBOCAN estimates, about 14.1 million new cancer cases and 8.2 million deaths occurred in 2012 worldwide. Over the years, the burden has shifted to less developed countries, which currently account for about 57% of cases and 65% of cancer deaths worldwide. Lung cancer is the leading cause of cancer death among males in both more and less developed countries, and has surpassed breast cancer as the leading cause of cancer death among females in more developed countries; breast cancer remains the leading cause of cancer death among females in less developed countries. Other leading causes of cancer death in more developed countries include colorectal cancer among males and females and prostate cancer among males. In less developed countries, liver and stomach cancer among males and cervical cancer among females are also leading causes of cancer death. Although incidence rates for all cancers combined are nearly twice as high in more developed than in less developed countries in both males and females, mortality rates are only 8% to 15% higher in more developed countries. This disparity reflects regional differences in the mix of cancers, which is affected by risk factors and detection practices, and/or the availability of treatment. Risk factors associated with the leading causes of cancer death include tobacco use (lung, colorectal, stomach, and liver cancer), overweight/obesity and physical inactivity (breast and colorectal cancer), and infection (liver, stomach, and cervical cancer). A substantial portion of cancer cases and deaths could be prevented by broadly

  6. Glutamate Water Gates in the Ion Binding Pocket of Na+ Bound Na+, K+-ATPase

    Science.gov (United States)

    Han, Minwoo; Kopec, Wojciech; Solov’yov, Ilia A.; Khandelia, Himanshu

    2017-01-01

    The dynamically changing protonation states of the six acidic amino acid residues in the ion binding pocket of the Na+, K+ -ATPase (NKA) during the ion transport cycle are proposed to drive ion binding, release and possibly determine Na+ or K+ selectivity. We use molecular dynamics (MD) and density functional theory (DFT) simulations to determine the protonation scheme of the Na+ bound conformation of NKA. MD simulations of all possible protonation schemes show that the bound Na+ ions are most stably bound when three or four protons reside in the binding sites, and that Glu954 in site III is always protonated. Glutamic acid residues in the three binding sites act as water gates, and their deprotonation triggers water entry to the binding sites. From DFT calculations of Na+ binding energies, we conclude that three protons in the binding site are needed to effectively bind Na+ from water and four are needed to release them in the next step. Protonation of Asp926 in site III will induce Na+ release, and Glu327, Glu954 and Glu779 are all likely to be protonated in the Na+ bound occluded conformation. Our data provides key insights into the role of protons in the Na+ binding and release mechanism of NKA. PMID:28084301

  7. Efeitos imediatos da MWM na dor, amplitude de movimento e funcionalidade, na osteoartrite da anca.

    OpenAIRE

    Beselga, Carlos

    2014-01-01

    Introdução: A mobilização com movimento (MWM), segundo o Conceito Mulligan tem apresentado bons resultados na melhoria da dor, amplitude de movimento e funcionalidade em diversas disfunções. No entanto, existem poucos estudos sobre a articulação da anca e, até este momento, não foi avaliada a sua efetividade em indivíduos com osteoartrite da anca. Objectivo(s): Avaliar os efeitos imediatos da técnica de MWM na dor, na amplitude de movimento e na função física em indivíduos com ...

  8. Cervical Cancer Screening | Cancer Trends Progress Report

    Science.gov (United States)

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  9. Ovarian Cancer Treatment | Cancer Trends Progress Report

    Science.gov (United States)

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  10. Elastic Coulomb breakup of 34Na

    Science.gov (United States)

    Singh, G.; Shubhchintak, Chatterjee, R.

    2016-08-01

    Background: 34Na is conjectured to play an important role in the production of seed nuclei in the alternate r -process paths involving light neutron rich nuclei very near the β -stability line, and as such, it is important to know its ground state properties and structure to calculate rates of the reactions it might be involved in, in the stellar plasma. Found in the region of `island of inversion', its ground state might not be in agreement with normal shell model predictions. Purpose: The aim of this paper is to study the elastic Coulomb breakup of 34Na on 208Pb to give us a core of 33Na with a neutron and in the process we try and investigate the one neutron separation energy and the ground state configuration of 34Na. Method: A fully quantum mechanical Coulomb breakup theory within the architecture of post-form finite range distorted wave Born approximation extended to include the effects of deformation is used to research the elastic Coulomb breakup of 34Na on 208Pb at 100 MeV/u. The triple differential cross section calculated for the breakup is integrated over the desired components to find the total cross-section, momentum, and angular distributions as well as the average momenta, along with the energy-angular distributions. Results: The total one neutron removal cross section is calculated to test the possible ground state configurations of 34Na. The average momentum results along with energy-angular calculations indicate 34Na to have a halo structure. The parallel momentum distributions with narrow full widths at half-maxima signify the same. Conclusion: We have attempted to analyze the possible ground state configurations of 34Na and in congruity with the patterns in the `island of inversion' conclude that even without deformation, 34Na should be a neutron halo with a predominant contribution to its ground state most probably coming from 33Na(3 /2+)⊗ 2 p3 /2ν configuration. We also surmise that it would certainly be useful and rewarding to test our

  11. A fadiga relacionada ao câncer como temática na enfermagem oncológica La fatiga relacionada al cáncer como temática en la enfermería oncológica Cancer-related fatigue as a thematic issue in oncology nursing

    OpenAIRE

    Maria de Fátima Batalha de Menezes; Teresa Caldas Camargo

    2006-01-01

    Este estudo objetiva buscar como a produção científica de Enfermagem Oncológica tem abordado a fadiga, associando-a com as características definidoras apontadas pela NANDA; e identificar as intervenções de Enfermagem que têm sido realizadas para sua prevenção e/ou tratamento nessas publicações, associando-as às intervenções citadas pela NIC. Trata-se de uma reflexão acerca da temática "fadiga" na área de Enfermagem Oncológica. Utilizou-se a revisão bibliográfica narrativa como método. As base...

  12. Testicular cancer.

    Science.gov (United States)

    Peckham, M

    1988-01-01

    Testicular cancer, which predominantly occurs in young men, has become increasingly common; it is presently the most common malignancy in men aged 20-34. Despite a lack of knowledge of aetiology, empirical advances, particularly in the management of patients with advanced disease, have been dramatic. Prior to the development of effective chemotherapy in the 1970s, less than 10% of men with metastatic non-seminomatous germ cell tumours were cured; nowadays approximately 90% of patients are potentially curable. The introduction of effective chemotherapy has led to a reappraisal of surgery and radiotherapy in the management of early stage disease and the introduction of a policy of surveillance in patients without evidence of metastases at the time of removal of the primary tumour. Following chemotherapy, surgery is required in approximately 25% of patients with advanced disease to excise residual masses, which in one-fifth of cases will show evidence of residual malignancy. In a proportion of patients, testicular cancer develops on a background of long-standing infertility, whereas in many men there is temporary oligospermia, despite a previous history of fertility. The majority of patients with prior evidence of spermatogenesis recover this function following chemotherapy and there is no evidence that children fathered by such patients have an increased risk of malformation. Despite physician optimism and excellent prospects for cure, significant psycho-social morbidity is associated with the diagnosis and treatment of testicular cancer. Factors contributing to this are being identified and will lead, hopefully, to the minimisation of such problems by appropriate intervention.

  13. [Gastric cancer].

    Science.gov (United States)

    Belén Fraile, M; Serra Bartual, M; Segarra Sánchez, J; Richart Rufino, M J

    1991-11-01

    Gastric cancer represents a disorder which incidence has come down last years. Its etiology is unknown, but diet is the principal determinant risk of suffering it. Clinic history is not much useful, because in the early stage symptoms can fail and in the late stage are inespecific. Election diagnosis is endoscopy. Surgery is the only curative treatment. By these features, it would be useful to left under vigilance to: a) patients 40 years older with dispepsia; b) patients following gastric operations; c) patients with disorders presenting aclorhidria. The authors report a clinic case that can be of frequent presentation in primary assistance.

  14. Dose effects of oxaliplatin on persistent and transient Na+ conductances and the development of neurotoxicity.

    Directory of Open Access Journals (Sweden)

    Susanna B Park

    Full Text Available BACKGROUND: Oxaliplatin, a platinum-based chemotherapy utilised in the treatment of colorectal cancer, produces two forms of neurotoxicity--acute sensorimotor neuropathic symptoms and a dose-limiting chronic sensory neuropathy. Given that a Na(+ channelopathy has been proposed as the mechanism underlying acute oxaliplatin-induced neuropathy, the present study aimed to determine specific mechanisms of Na(+ channel dysfunction. METHODOLOGY/PRINCIPAL FINDINGS: Specifically the function of transient and persistent Na(+ currents were followed during treatment and were investigated in relation to oxaliplatin dose level. Eighteen patients were assessed before and after a single oxaliplatin infusion with motor and sensory axonal excitability studies performed on the median nerve at the wrist. While refractoriness (associated with Na(+ channel inactivation was significantly altered post-oxaliplatin infusion in both motor (Pre: 31.7±6.4%; Post: 68.8±14.5%; P≤.001 and sensory axons (Pre: 31.4±5.4%; Post: 21.4±5.5%; P<.05, strength-duration time constant (marker of persistent Na(+ conductances was not significantly altered post-infusion (Motor Pre: 0.395±0.01 ms; Post: 0.394±0.02 ms; NS; Sensory Pre:0.544±0.03 ms; Post: 0.535±0.05 ms; NS. However, changes in strength-duration time constant were significantly correlated with changes in refractoriness in motor and sensory axons (Motor correlation coefficient = -.65; P<.05; Sensory correlation coefficient = .67; P<.05. CONCLUSIONS/SIGNIFICANCE: It is concluded that the predominant effect of acute oxaliplatin exposure in human motor and sensory axons is mediated through changes in transient rather than persistent Na(+ conductances. These findings are likely to have implications for the design and trial of neuroprotective strategies.

  15. Quasi-solid state rechargeable Na-CO2 batteries with reduced graphene oxide Na anodes.

    Science.gov (United States)

    Hu, Xiaofei; Li, Zifan; Zhao, Yaran; Sun, Jianchao; Zhao, Qing; Wang, Jianbin; Tao, Zhanliang; Chen, Jun

    2017-02-01

    Na-CO2 batteries using earth-abundant Na and greenhouse gas CO2 are promising tools for mobile and stationary energy storage, but they still pose safety risks from leakage of liquid electrolyte and instability of the Na metal anode. These issues result in extremely harsh operating conditions of Na-CO2 batteries and increase the difficulty of scaling up this technology. We report the development of quasi-solid state Na-CO2 batteries with high safety using composite polymer electrolyte (CPE) and reduced graphene oxide (rGO) Na anodes. The CPE of PVDF-HFP [poly(vinylidene fluoride-co-hexafluoropropylene)]-4% SiO2/NaClO4-TEGDME (tetraethylene glycol dimethyl ether) has high ion conductivity (1.0 mS cm(-1)), robust toughness, a nonflammable matrix, and strong electrolyte-locking ability. In addition, the rGO-Na anode presents fast and nondendritic Na(+) plating/stripping (5.7 to 16.5 mA cm(-2)). The improved kinetics and safety enable the constructed rGO-Na/CPE/CO2 batteries to successfully cycle in wide CO2 partial pressure window (5 to 100%, simulated car exhaust) and especially to run for 400 cycles at 500 mA g(-1) with a fixed capacity of 1000 mA·hour g(-1) in pure CO2. Furthermore, we scaled up the reversible capacity to 1.1 A·hour in pouch-type batteries (20 × 20 cm, 10 g, 232 Wh kg(-1)). This study makes quasi-solid state Na-CO2 batteries an attractive prospect.

  16. Quasi–solid state rechargeable Na-CO2 batteries with reduced graphene oxide Na anodes

    Science.gov (United States)

    Hu, Xiaofei; Li, Zifan; Zhao, Yaran; Sun, Jianchao; Zhao, Qing; Wang, Jianbin; Tao, Zhanliang; Chen, Jun

    2017-01-01

    Na-CO2 batteries using earth-abundant Na and greenhouse gas CO2 are promising tools for mobile and stationary energy storage, but they still pose safety risks from leakage of liquid electrolyte and instability of the Na metal anode. These issues result in extremely harsh operating conditions of Na-CO2 batteries and increase the difficulty of scaling up this technology. We report the development of quasi–solid state Na-CO2 batteries with high safety using composite polymer electrolyte (CPE) and reduced graphene oxide (rGO) Na anodes. The CPE of PVDF-HFP [poly(vinylidene fluoride-co-hexafluoropropylene)]–4% SiO2/NaClO4–TEGDME (tetraethylene glycol dimethyl ether) has high ion conductivity (1.0 mS cm−1), robust toughness, a nonflammable matrix, and strong electrolyte-locking ability. In addition, the rGO-Na anode presents fast and nondendritic Na+ plating/stripping (5.7 to 16.5 mA cm−2). The improved kinetics and safety enable the constructed rGO-Na/CPE/CO2 batteries to successfully cycle in wide CO2 partial pressure window (5 to 100%, simulated car exhaust) and especially to run for 400 cycles at 500 mA g−1 with a fixed capacity of 1000 mA·hour g−1 in pure CO2. Furthermore, we scaled up the reversible capacity to 1.1 A·hour in pouch-type batteries (20 × 20 cm, 10 g, 232 Wh kg−1). This study makes quasi–solid state Na-CO2 batteries an attractive prospect. PMID:28164158

  17. Collection of Biospecimen & Clinical Information in Patients w/ Gastrointestinal Cancers

    Science.gov (United States)

    2012-05-24

    Gastrointestinal Neoplasms; Gynecologic Cancers; Gynecologic Cancers Cervical Cancer; Gastric (Stomach) Cancer; Gastro-Esophageal(GE) Junction Cancer; Gastrointenstinal Stromal Tumor (GIST); Colon/Rectal Cancer; Colon/Rectal Cancer Colon Cancer; Colon/Rectal Cancer Rectal Cancer; Colon/Rectal Cancer Anal Cancer; Anal Cancer; Hepatobiliary Cancers; Hepatobiliary Cancers Liver; Pancreatic Cancer

  18. O Passeio Público do Rio de Janeiro na Literatura, na Pintura e na Fotografia do Século XIX

    Directory of Open Access Journals (Sweden)

    Solange de Aragão

    2012-06-01

    Full Text Available Este artigo tem como objetivo geral e mais amplo chamar a atenção dos pesquisadores para a importância da literatura, da pintura e da fotografia como fontes documentais para a construção da História do Paisagismo no Brasil por meio de um estudo de caso muito particular: o Passeio Público do Rio de Janeiro no século XIX. São objetivos específicos apresentar e analisar o modo como esse espaço livre público aparece na literatura, na pintura e na fotografia desse período, considerando suas transformações paisagísticas.

  19. Na+ channel β subunits: Overachievers of the ion channel family

    Directory of Open Access Journals (Sweden)

    William J Brackenbury

    2011-09-01

    Full Text Available Voltage gated Na+ channels (VGSCs in mammals contain a pore-forming α subunit and one or more β subunits. There are five mammalian β subunits in total: β1, β1B, β2, β3, and β4, encoded by four genes: SCN1B-SCN4B. With the exception of the SCN1B splice variant, β1B, the β subunits are type I topology transmembrane proteins. In contrast, β1B lacks a transmembrane domain and is a secreted protein. A growing body of work shows that VGSC β subunits are multifunctional. While they do not form the ion channel pore, β subunits alter gating, voltage-dependence, and kinetics of VGSC α subunits and thus regulate cellular excitability in vivo. In addition to their roles in channel modulation, β subunits are members of the immunoglobulin (Ig superfamily of cell adhesion molecules (CAMs and regulate cell adhesion and migration. β subunits are also substrates for sequential proteolytic cleavage by secretases. An example of the multifunctional nature of β subunits is β1, encoded by SCN1B, that plays a critical role in neuronal migration and pathfinding during brain development, and whose function is dependent on Na+ current and γ-secretase activity. Functional deletion of SCN1B results in Dravet Syndrome, a severe and intractable pediatric epileptic encephalopathy. β subunits are emerging as key players in a wide variety of pathophysiologies, including epilepsy, cardiac arrhythmia, multiple sclerosis, Huntington’s disease, neuropsychiatric disorders, neuropathic and inflammatory pain, and cancer. β subunits mediate multiple signaling pathways on different timescales, regulating electrical excitability, adhesion, migration, pathfinding, and transcription. Importantly, some β subunit functions may operate independent of α subunits. Thus, β subunits perform critical roles during development and disease. As such, they may prove useful in disease diagnosis and therapy.

  20. Shorter telomere length of T-cells in peripheral blood of patients with lung cancer

    Directory of Open Access Journals (Sweden)

    Qian Y

    2016-05-01

    Full Text Available Yaqin Qian,1–3,* Tingting Ding,1–3,* Lijuan Wei,2 Shui Cao,2–4 Lili Yang1–3 1Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, People’s Republic of China; 2National Clinical Research Center of Cancer, Tianjin, People’s Republic of China; 3Tianjin Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, People’s Republic of China; 4Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, People’s Republic of China *These authors contributed equally to this work Purpose: Telomere shortening occurs in tumor tissues and peripheral blood lymphocytes of many common human malignancies, including lung cancer, but its variation in T-cells has never been investigated. Thus, the aim of this study was to assess telomere length in T-cells and its correlation with the clinical characteristics of patients with lung cancer.Patients and methods: A total of 40 patients with lung cancer but without prior cancer history and 25 healthy individuals were selected. T-cells were isolated and their telomere lengths were measured using quantitative real-time polymerase chain reaction methods.Results: Telomere length in T-cells was significantly shorter in patients with lung cancer than in controls (P<0.001. Shorter telomere length was significantly associated with increased clinical stage (P=0.008 and distant metastasis (P=0.028. Naïve T-cells from patients with lung cancer had significantly decreased telomere length when compared with those from controls (P=0.012.Conclusion: The shortened telomere length in T-cells occurred in naïve T-cells and might be related to lung cancer progression. Keywords: tumor, telomere’s activity, naïve T-cell, immunocompromise, telomere shortening, T lymphocytes

  1. Mesoporous NaYbF4@NaGdF4 core-shell up-conversion nanoparticles for targeted drug delivery and multimodal imaging.

    Science.gov (United States)

    Zhou, Liangjun; Zheng, Xiaopeng; Gu, Zhanjun; Yin, Wenyan; Zhang, Xiao; Ruan, Longfei; Yang, Yanbo; Hu, Zhongbo; Zhao, Yuliang

    2014-08-01

    We developed a facile strategy to obtain a new kind of mesoporous core-shell structured up-conversion nanoparticles (mUCNPs), composed of a NaYbF4:2%Er core and a mesoporous NaGdF4 shell. This mesoporous shell not only enhanced the up-conversion luminescence but also endowed many other functionalities of the nanoparticles such as drug delivery and bio-imaging capabilities. Moreover, after being conjugated with polyethylenimine (PEI) and folic acid (FA), core-shell mUCNPs exhibited good water dispersibility, enhanced drug delivery efficiency, and remarkable targeting ability to cancer cells. To certify the folate receptors (FR)-mediated targeted drug delivery, cell viability assay, cell up-conversion luminescence imaging and flow cytometry analysis were carried out. Furthermore, apart from the application for targeted drug delivery, the as-prepared core-shell mUCNPs could also be employed as the contrast agents for X-ray computed tomography (CT) and magnetic resonance (MR) imaging, because of the strong X-ray attenuation ability of Yb and high longitudinal molar relaxivity (r1) of Gd in the nanoparticles, providing the potential for simultaneously bio-imaging and cancer-targeting therapy.

  2. Monitoramento auditivo na ototoxidade Auditory monitoring in ototoxicity

    Directory of Open Access Journals (Sweden)

    Lilian Cassia Bornia Jacob

    2006-12-01

    Full Text Available Algumas drogas, denominadas ototóxicas, têm a capacidade de lesar os sistemas auditivo e vestibular. O avanço tecnológico tem disponibilizado inúmeros recursos para realizar o monitoramento da audição, porém, apesar da disponibilização de protocolos de avaliação internacionais, existem controvérsias quanto à escolha do procedimento de maior sensibilidade e especificidade para este fim. OBJETIVO: Analisar os procedimentos audiológicos utilizados no monitoramento auditivo dos indivíduos expostos à medicação ototóxica. METODOLOGIA: Realizou-se busca eletrônica nas bases de dados MEDLINE e LILACS, a partir da combinação entre os descritores que caracterizaram as temáticas monitoramento auditivo, ototoxicidade e câncer. A literatura apontou dois principais procedimentos efetivos no monitoramento: a audiometria de altas freqüências e as emissões otoacústicas. Ambos permitem que a alteração no sistema auditivo seja identificada antes que haja um comprometimento dos limiares tonais na faixa de freqüências convencional, e conseqüentemente na habilidade de compreensão da fala. CONCLUSÃO: O protocolo de monitoramento auditivo foi sugerido considerando a capacidade do paciente em responder aos testes comportamentais e a etapa do monitoramento (primeira avaliação ou subseqüentes. No caso de portadores de câncer, o monitoramento auditivo deve ser disponibilizado no local de tratamento do indivíduo.Some pharmaceutical products are capable of damaging the human auditory system. Technological progress has provided numerous resources to monitor hearing but there still is some controversy regarding the selection of the most sensitive and specific tests. OBJECTIVE: to analyze audiological procedures used in the auditory monitoring of individuals exposed to ototoxic medication. METHODS: we searched the MEDLINE and LILACS literature databases, using terms pertinent to audiological monitoring, ototoxicity and cancer. The

  3. Associations between CYP19A1 polymorphisms, Native American ancestry, and breast cancer risk and mortality: the Breast Cancer Health Disparities Study.

    Science.gov (United States)

    Boone, Stephanie D; Baumgartner, Kathy B; Baumgartner, Richard N; Connor, Avonne E; Pinkston, Christina M; Rai, Shesh N; Riley, Elizabeth C; Hines, Lisa M; Giuliano, Anna R; John, Esther M; Stern, Mariana C; Torres-Mejía, Gabriela; Wolff, Roger K; Slattery, Martha L

    2014-11-01

    The cytochrome p450 family 19 gene (CYP19A1) encodes for aromatase, which catalyzes the final step in estrogen biosynthesis and conversion of androgens to estrogens. Genetic variation in CYP19A1 is linked to higher circulating estrogen levels and increased aromatase expression. Using data from the Breast Cancer Health Disparities Study, a consortium of three population-based case-control studies in the United States (n = 3,030 non-Hispanic Whites; n = 2,893 Hispanic/Native Americans (H/NA) and Mexico (n = 1,810), we examined influence of 25 CYP19A1 tagging single-nucleotide polymorphisms (SNPs) on breast cancer risk and mortality, considering NA ancestry. Odds ratios (ORs) and 95 % confidence intervals (CIs) and hazard ratios estimated breast cancer risk and mortality. After multiple comparison adjustment, none of the SNPs were significantly associated with breast cancer risk or mortality. Two SNPs remained significantly associated with increased breast cancer risk in women of moderate to high NA ancestry (≥29 %): rs700518, ORGG 1.36, 95 % CI 1.11-1.67 and rs11856927, ORGG 1.35, 95 % CI 1.05-1.72. A significant interaction was observed for rs2470144 and menopausal status (p adj = 0.03); risk was increased in postmenopausal (ORAA 1.22, 95 % CI 1.05-1.14), but not premenopausal (ORAA 0.78, 95 % CI 0.64-0.95) women. The absence of an overall association with CYP19A1 and breast cancer risk is similar to previous literature. However, this analysis provides support that variation in CYP19A1 may influence breast cancer risk differently in women with moderate to high NA ancestry. Additional research is warranted to investigate the how variation in an estrogen-regulating gene contributes to racial/ethnic disparities in breast cancer.

  4. Breast cancer awareness

    OpenAIRE

    2012-01-01

    The incidence of breast cancer is rising among women in many European countries, affecting up to 1 in 16 women and has become the most common cause of cancer in European women. In Malta breast cancer is the commonest oncological cause of death in females. In fact 5.2% of all deaths in females in 2010 was from breast cancer.

  5. Cancer and Women

    Science.gov (United States)

    ... I J K L M N O P Q R S T U V W X Y Z # ... CDC.gov . Cancer Home Kinds of Cancer Bladder Breast Cervical Colorectal (Colon) Head and Neck Kidney Leukemia ... Anxiety and Depression Medicine Use Among Cancer Survivors Breast Cancer Rates Among Black Women and White Women ...

  6. Advanced Cancer Detection Center

    Science.gov (United States)

    2000-10-01

    Coeur d’Alene, ID IASLC 9th World Conference on Lung Cancer, Cellular Targeting in the Molecular Diagnosis of Lung Cancer, Tokyo, Japan The...World Conference on Lung Cancer, Cellular Targeting in the Molecular Diagnosis of Lung Cancer, Tokyo, Japan The first International Conference on

  7. Report: Human cancer genetics

    Institute of Scientific and Technical Information of China (English)

    LI Marilyn; ALBERTSON Donna

    2006-01-01

    The short report will be focused on the genetic basis and possible mechanisms of tumorigenesis, common types of cancer, the importance of genetic diagnosis of cancer, and the methodology of cancer genetic diagnosis. They will also review presymptomatic testing of hereditary cancers, and the application of expression profiling to identify patients likely to benefit from particular therapeutic approaches.

  8. Primary Peritoneal Cancer

    Science.gov (United States)

    ... 4059 FWCinfo@sgo.org Copyright © 2017 Foundation for Women’s Cancer. All rights reserved. Site Design by Nov. 6, 2016 REGISTER ... to End Women’s Cancer Press Release: Foundation for Women’s Cancer ... Gynecologic Cancer Awareness Movement (GCAM) to be Featured on Times Square “Super ...

  9. Symptoms of Ovarian Cancer

    Science.gov (United States)

    ... Informed Cancer Home What Are the Symptoms of Ovarian Cancer? Language: English Español (Spanish) Recommend on Facebook Tweet Share Compartir Gynecologic cancer symptoms diaries Ovarian cancer may cause the following signs and symptoms— Vaginal ...

  10. Staging of Lung Cancer

    Science.gov (United States)

    ... is important for two reasons. First, staging your lung cancer helps decide which therapy (or therapies) should be used. Second, lung cancer ... 422-6237 http://www.cancer.gov/cancertopics/wyntk/lung/page8 http://www.cancer.gov/cancertopics/pdq/treatment/non- small-cell-lung/Patient/page2 National Lung ...

  11. Human cancer genetics*

    OpenAIRE

    2006-01-01

    The short report will be focused on the genetic basis and possible mechanisms of tumorigenesis, common types of cancer, the importance of genetic diagnosis of cancer, and the methodology of cancer genetic diagnosis. They will also review presymptomatic testing of hereditary cancers, and the application of expression profiling to identify patients likely to benefit from particular therapeutic approaches.

  12. | Division of Cancer Prevention

    Science.gov (United States)

    The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

  13. Cigar Smoking and Cancer

    Science.gov (United States)

    ... cancer and other diseases? Yes. Cigar smoking causes cancer of the oral cavity, larynx, esophagus, and lung. It may also cause cancer ... directly expose their lips, mouth, tongue, throat, and larynx to smoke and its toxic and cancer-causing chemicals. In addition, when saliva containing the ...

  14. Breast cancer in men

    Science.gov (United States)

    ... in situ - male; Intraductal carcinoma - male; Inflammatory breast cancer - male; Paget disease of the nipple - male; Breast cancer - male ... The cause of breast cancer in men is not clear. But there are risk factors that make breast cancer more likely in men: Exposure to ...

  15. What Is Kidney Cancer (Renal Cell Carcinoma)?

    Science.gov (United States)

    ... Treatment? Kidney Cancer About Kidney Cancer What Is Kidney Cancer? Kidney cancer is a cancer that starts ... and spread, see What Is Cancer? About the kidneys To understand more about kidney cancer, it helps ...

  16. Breast Cancer Early Detection and Diagnosis

    Science.gov (United States)

    ... En Español Category Cancer A-Z Breast Cancer Breast Cancer Early Detection and Diagnosis Breast cancer is sometimes ... cancer screening is so important. Learn more. Can Breast Cancer Be Found Early? Breast cancer is sometimes found ...

  17. Cancer Biomarkers | Division of Cancer Prevention

    Science.gov (United States)

    [[{"fid":"175","view_mode":"default","fields":{"format":"default","field_file_image_alt_text[und][0][value]":"Cancer Biomarkers Research Group Homepage Logo","field_file_image_title_text[und][0][value]":"Cancer Biomarkers Research Group Homepage Logo","field_folder[und]":"15"},"type":"media","attributes":{"alt":"Cancer Biomarkers Research Group Homepage Logo","title":"Cancer Biomarkers Research Group Homepage Logo","height":"266","width":"400","style":"width: 400px; height: 266px;","class":"i | Research to identify, develop and validate biomarkers for early cancer detection and risk assessment.

  18. [The Dutch Cancer Society Cancer Risk Test].

    Science.gov (United States)

    Elias, Sjoerd G; Grooters, Hilda G; Bausch-Goldbohm, R A Sandra; van den Brandt, Piet A; Kampman, Ellen; van Leeuwen, Flora E; Peeters, Petra H M; de Vries, Esther; Wigger, Stefan; Kiemeney, L A L M Bart

    2012-01-01

    The Dutch Cancer Society developed the 'KWF Kanker Risico Test' (Cancer Risk Test) to improve the information available to the Dutch population regarding cancer risk factors. This Internet test, based under licence on the American 'Your Disease Risk' test, informs users about risk factors for 12 common types of cancer. The test provides an estimate of individual risk of a specific type of cancer and gives specific lifestyle advice that could lower that risk. This paper describes the development of the test, how it works, and its strengths and limitations.

  19. Voltage dependence of Na translocation by the Na/K pump.

    Science.gov (United States)

    Nakao, M; Gadsby, D C

    During each complete reaction cycle, the Na/K pump transports three Na ions out across the cell membrane and two K ions in. The resulting net extrusion of positive charge generates outward membrane current but, until now, it was unclear how that net charge movement occurs. Reasonable possibilities included a single positive charge moving outwards during Na translocation; or a single negative charge moving inwards during K translocation; or either positive or negative charges moving during both translocation steps, but in unequal quantities. Any step that involves net charge movement through the membrane must have voltage-dependent transition rates. Here we report measurements of transient, voltage-dependent, displacement currents generated by the pump when its normal Na/K transport cycle has been interrupted by removal of external K and it is thus constrained to carry out Na/Na exchange. The quantity and voltage sensitivity of the charge moved during these transient currents suggests that Na translocation includes a voltage-dependent transition involving movement of one positive charge across the membrane. This single step can thus fully account for the electrogenic nature of Na/K exchange. The result provides important new insight into the molecular mechanism of active cation transport.

  20. Prevalência do papilomavírus humano (HPV na cavidade oral e na orofaringe Prevalence of human papillomavirus (HPV in oral cavity and oropharynx

    Directory of Open Access Journals (Sweden)

    Therezita Peixoto Patury Galvão Castro

    2006-04-01

    Full Text Available A prevalência do papilomavírus humano (HPV na cavidade oral e na orofaringe ainda não está bem esclarecida como nos estudos do trato genital, na qual é bem definida. Entretanto, novas pesquisas estão surgindo após o aparecimento dos exames de biologia molecular. Neste estudo foi realizada uma revisão da literatura com o objetivo de verificar a prevalência do papilomavírus humano na cavidade oral e na orofaringe. Os resultados desta pesquisa mostraram uma prevalência do HPV 16 na mucosa oral normal (infecção latente. Já nas lesões benignas orais associadas ao HPV mostraram uma prevalência do HPV 6 e 11 em papilomas de células escamosas e condilomas, e, nas verrugas, uma prevalência do HPV 2 e 57, enquanto na hiperplasia epitelial focal prevaleceram os HPVs 13 e 32, e no câncer oral, principalmente, no carcinoma de células escamosas (CCE, foi evidenciada uma alta prevalência do HPV 16, o que sugere sua participação na carcinogênese oral, apesar de ser um assunto controverso. Constatou-se também uma enorme discrepância nos resultados da prevalência do papilomavírus humano (HPV na mucosa oral normal (infecção latente e no câncer oral, enquanto nas lesões benignas associadas ao vírus, os resultados foram confirmatórios.The prevalence of human papillomavirus (HPV in the oral cavity and oropharynx has not yet been as well studied as its infection of the vaginal tract. However, new study are emerge after the development of molecular biology techniques. The objective of this study is to show the prevalence of HPV in the oral cavity and the oropharynx. An ample bibliographic review was done showing a prevalence of HPV 6, 11 in a normal oral mucous membrane (latent infection. In oral benign lesions associated with HPV, a prevalence of HPV 6 and 11 was observed in squamous cell papilloma (SCP and condylomas acuminatum, while HPV 2 and 57 were more prevalent in verruca vulgaris lesions. As for focal epithelial hyperplasia

  1. Role of wild type p53 and double suicide genes in interventional therapy of liver cancer in rabbits Papel do p53 selvagem e do duplo genes suicidas na terapia intervencionista do câncer de fígado em coelhos

    Directory of Open Access Journals (Sweden)

    Hong-xin Niu

    2012-08-01

    Full Text Available PURPOSE: To investigate the feasibility of interventional lipiodol embolism and multigene therapy in combination with focal chemotherapy in the treatment of VX2 liver cancer in rabbits. METHODS: Forty five rabbits with cancer larger than 2cm in diameter were randomly divided into five groups (n=9 per group. In Group 1, animals were treated with 0.9% sodium chloride. In Group 2, animals received lipiodol embolism. In Group 3, animals received lipiodol embolism and p53 gene therapy. In Group 4, animals received lipiodol embolism and TK/CD gene therapy. In Group 5, animals received lipiodol embolism and p53 and TK/CD gene therapy. Ultrasonography and CT were performed before and at ten days after interventional therapy. RESULTS: The VX2 model of liver cancer was successfully established in rabbits and interventional therapy smoothly performed. At ten days after interventional therapy, significant difference in the tumor volume was noted among five groups (pOBJETIVO: Investigar a possibilidade de terapia multigênica e intervenção por embolização com lipiodol em combinação com quimioterapia focal no tratamento de câncer de fígado VX2 em coelhos. MÉTODOS: Quarenta e cinco coelhos com câncer maior do que 2cm de diâmetro foram distribuídos, aleatoriamente, em cinco grupos (n=9 por grupo. Grupo 1: animais foram tratados com cloreto de sódio 0,9% e no grupo 2 os animais receberam embolização com lipidol. Grupo 3: animais receberam embolização com lipiodol e terapia do gene p53 e grupo 4 animais receberam embolização com lipiodol e terapia do gene TK/CD. Grupo 5: animais receberam embolização com lipiodol e terapia do gene p53 e do gene TK/CD. Ultrassonografia e tomografia computadorizada foram realizadas antes e dez dias após a intervenção terapêutica. RESULTADOS: O modelo VX2 de câncer de fígado foi estabelecido com sucesso em coelhos e a terapia intervencionista foi bem executada. Dez dias após a intervenção terap

  2. Fatores dietéticos e câncer oral: estudo caso-controle na Região Metropolitana de São Paulo, Brasil Dietary factors and oral cancer: a case-control study in Greater Metropolitan São Paulo, Brazil

    Directory of Open Access Journals (Sweden)

    Dirce Maria Lobo Marchioni

    2007-03-01

    Full Text Available Neste estudo, investigou-se os fatores dietéticos associados com o câncer oral, em um estudo tipo caso-controle de base hospitalar no Município de São Paulo, Brasil, entre 1998 e 2002. Participaram 835 indivíduos, sendo 366 casos incidentes de câncer de cavidade oral ou faringe e 469 controles. Os dados de consumo alimentar foram obtidos por um Questionário de Freqüência Alimentar (QFA. Os valores de odds ratio (OR e intervalos com 95% de confiança (IC95% foram estimados por regressão logística não condicional, ajustada por potenciais fatores de confusão. Verificaram-se associações inversas entre o câncer oral e o consumo mais elevado de feijão, OR = 0,37 (IC95%: 0,22-0,64, vegetais crus, OR = 0,51 (IC95%: 0,29-0,93 e para o tercil intermediário de arroz e massas, OR = 0,56 (IC95%: 0,38-0,83. Associações diretas foram observadas para o mais elevado consumo de ovos, OR = 1,84 (IC95%: 1,23-2,75, batata, OR = 2,22 (IC95%: 1,53-3,25 e leite, OR= 1,80 (IC95%: 1,09-2,98. Alimentos básicos da dieta do brasileiro, como arroz e feijão, emergiram como fatores de proteção para o câncer oral, independente de outros fatores de risco.Dietary factors associated with oral cancer were investigated in a case-control hospital-based study in the city of São Paulo, Brazil, from 1998 to 2002. A total of 835 subjects, 366 with histologically confirmed incident cases of oral-cavity or pharyngeal cancer and 469 controls participated in the study. Dietary data were collected with a food frequency questionnaire (FFQ. Odds ratios (OR and 95% confidence intervals (95%CI were obtained from unconditional logistic regression, adjusted for potential confounders. Inverse associations with risk of oral cancer were found for the highest intake of beans, OR = 0.37 (95%CI: 0.22-0.64, raw vegetables, OR = 0.51 (95%CI: 0.29-0.93 and the intermediate tertile of rice and pasta intake, OR = 0.56 (95%CI: 0.38-0.83. Positive associations were observed for the

  3. Telomerers rolle i cancer

    DEFF Research Database (Denmark)

    Bendix, Laila; Kølvraa, Steen

    2010-01-01

    Telomeres are a double-edged sword when it comes to cancer. On one hand, telomeres limit the cells' ability to divide and thereby restrict the uninhibited growth seen in cancer. On the other hand, short telomeres can initiate the chromosome instability that characterizes cancer. Diseases...... with the combination of short telomeres and high cancer risk are seen, but until now the use of telomeres as predictors of cancer has, in general, been unsuccessful. Telomeres and telomerase play an important role in further cancer development. Researchers are trying to exploit this in the development of new cancer...

  4. Inherited pancreatic cancer syndromes.

    Science.gov (United States)

    Solomon, Sheila; Das, Siddhartha; Brand, Randall; Whitcomb, David C

    2012-01-01

    Pancreatic cancer remains one of the most challenging of all cancers. Genetic risk factors are believed to play a major role, but other than genes coding for blood group, genetic risks for sporadic cases remain elusive. However, several germline mutations have been identified that lead to hereditary pancreatic cancer, familial pancreatic cancer, and increased risk for pancreatic cancer as part of a familial cancer syndrome. The most important genes with variants increasing risk for pancreatic cancer include BRCA1, BRCA2, PALB2, ATM, CDKN2A, APC, MLH1, MSH2, MSH6, PMS2, PRSS1, and STK11. Recognition of members of high-risk families is important for understanding pancreatic cancer biology, for recommending risk reduction strategies and, in some cases, initiating cancer surveillance programs. Because the best methods for surveillance have not been established, the recommendation to refer at-risk patients to centers with ongoing research programs in pancreatic cancer surveillance is supported.

  5. Lung cancer after treatment for breast cancer.

    Science.gov (United States)

    Lorigan, Paul; Califano, Raffaele; Faivre-Finn, Corinne; Howell, Anthony; Thatcher, Nick

    2010-12-01

    Breast cancer is the most common cancer in women, and the second most common cause of cancer death after lung cancer. Improvements in the outcome of breast cancer mean that more patients are living longer and are, therefore, at risk of developing a second malignancy. The aim of this review is to present the current understanding of the risk of lung cancer arising in patients previously treated for early stage breast cancer. We review data on the effect of treatment factors (ie, surgery type, radiotherapy technique, and adjuvant chemotherapy) and patient factors (ie, age and smoking) on the risk of developing a subsequent lung cancer. The evidence suggests that older radiotherapy techniques were associated with a substantially increased risk of developing lung cancer in the ipsilateral lung, but there is no clear evidence of an increased risk with modern techniques. Smoking is an important risk factor, and increases the risk of lung cancer in those receiving radiotherapy. Adjuvant chemotherapy is not significantly associated with an increased risk. The risk of developing lung cancer increases with time elapsed since treatment, but any effect of age at treatment is unclear.

  6. Metallic Na formation in NaCl crystals with irradiation of electron or vacuum ultraviolet photon

    Energy Technology Data Exchange (ETDEWEB)

    Owaki, Shigehiro [Osaka Prefecture Univ., Sakai, Osaka (Japan). Coll. of Integrated Arts and Sciences; Koyama, Shigeko; Takahashi, Masao; Kamada, Masao; Suzuki, Ryouichi

    1997-03-01

    Metallic Na was formed in NaCl single crystals with irradiation of a variety of radiation sources and analyzed the physical states with several methods. In the case of irradiation of 21 MeV electron pulses to the crystal blocks, the optical absorption and lifetime measurement of positron annihilation indicated appearance of Na clusters inside. Radiation effects of electron beam of 30 keV to the crystals in vacuum showed the appearance of not only metallic Na but atomic one during irradiation with Auger electron spectroscopy. Intense photon fluxes in vacuum ultraviolet region of synchrotron radiation were used as another source and an analyzing method of ultraviolet photoelectron spectroscopy. The results showed the metallic Na layered so thick that bulk plasmon can exist. (author)

  7. Summer sudden Na number density enhancements measured with the ALOMAR Weber Na Lidar

    Directory of Open Access Journals (Sweden)

    D. Heinrich

    2008-05-01

    Full Text Available We present summer Na-densities and atmospheric temperatures measured 80 to 110 km above the Arctic Lidar Observatory for Middle Atmosphere Research (ALOMAR. The Weber Na Lidar is part of ALOMAR, located at 69° N in Norway, 150 km north of the Arctic Circle. The sun does not set here during the summer months, and measurements require a narrowband Faraday Anomalous Dispersion Optical Filter (FADOF.

    We discuss an observed sudden enhancement in the Na number density around 22:00 UT on 1 to 2 June 2006. We compare this observation with previous summer measurements and find a frequent appearance of Na number density enhancements near local midnight. We describe the time of appearance, the altitude distribution, the duration and the strength of these enhancements and compare them to winter observations. We investigate possible formation mechanisms and, as others before, we find a strong link between these Na number density enhancements and sporadic E layers.

  8. Efeitos da cafeína na performance de exercícios de endurance

    Directory of Open Access Journals (Sweden)

    Giuliano Roberto da Silva

    2015-10-01

    Full Text Available Objetivo: verificar os efeitos da cafeína na performance de exercícios de endurance, através do teste de exaustão na bicicleta ergométrica. Método: participaram 50 indivíduos do sexo masculino, submetidos ao teste de exaustão em cicloergômetro após ingestão de 6mg/kg de cafeína (CAF (n=25; grupo cafeína, e 6mg/kg de placebo (PLA (n=25; grupo placebo, 40 minutos antes do teste. Os dados foram tratados estatisticamente, submetidos ao teste t de Student (p

  9. National Cancer Institute Prostate Cancer Genetics Workshop.

    Science.gov (United States)

    Catalona, William J; Bailey-Wilson, Joan E; Camp, Nicola J; Chanock, Stephen J; Cooney, Kathleen A; Easton, Douglas F; Eeles, Rosalind A; FitzGerald, Liesel M; Freedman, Matthew L; Gudmundsson, Julius; Kittles, Rick A; Margulies, Elliott H; McGuire, Barry B; Ostrander, Elaine A; Rebbeck, Timothy R; Stanford, Janet L; Thibodeau, Stephen N; Witte, John S; Isaacs, William B

    2011-05-15

    Compelling evidence supports a genetic component to prostate cancer susceptibility and aggressiveness. Recent genome-wide association studies have identified more than 30 single-nucleotide polymorphisms associated with prostate cancer susceptibility. It remains unclear, however, whether such genetic variants are associated with disease aggressiveness--one of the most important questions in prostate cancer research today. To help clarify this and substantially expand research in the genetic determinants of prostate cancer aggressiveness, the first National Cancer Institute Prostate Cancer Genetics Workshop assembled researchers to develop plans for a large new research consortium and patient cohort. The workshop reviewed the prior work in this area and addressed the practical issues in planning future studies. With new DNA sequencing technology, the potential application of sequencing information to patient care is emerging. The workshop, therefore, included state-of-the-art presentations by experts on new genotyping technologies, including sequencing and associated bioinformatics issues, which are just beginning to be applied to cancer genetics.

  10. Induced radioactivity in the blood of cancer patients following Boron Neutron Capture Therapy.

    Science.gov (United States)

    Fujiwara, Keiko; Kinashi, Yuko; Takahashi, Tomoyuki; Yashima, Hiroshi; Kurihara, Kouta; Sakurai, Yoshinori; Tanaka, Hiroki; Ono, Koji; Takahashi, Sentaro

    2013-07-01

    Since 1990, Boron Neutron Capture Therapy (BNCT) has been used for over 400 cancer patients at the Kyoto University Research Reactor Institute (KURRI). After BNCT, the patients are radioactive and their (24)Na and (38)Cl levels can be detected via a Na-I scintillation counter. This activity is predominantly due to (24)Na, which has a half-life of 14.96 h and thus remains in the body for extended time periods. Radioactive (24)Na is mainly generated from (23)Na in the target tissue that is exposed to the neutron beam in BNCT. The purpose of this study is to evaluate the relationship between the radioactivity of blood (24)Na following BNCT and the absorbed gamma ray dose in the irradiated field. To assess blood (24)Na, 1 ml of peripheral blood was collected from 30 patients immediately after the exposure, and the radioactivity of blood (24)Na was determined using a germanium counter. The activity of (24)Na in the blood correlated with the absorbed gamma ray doses in the irradiated field. For the same absorbed gamma ray dose in the irradiated field, the activity of blood (24)Na was higher in patients with neck or lung tumors than in patients with brain or skin tumors. The reasons for these findings are not readily apparent, but the difference in the blood volume and the ratio of bone to soft tissue in the irradiated field, as well as the dose that leaked through the clinical collimator, may be responsible.

  11. Normal SUV values measured from NaF18- PET/CT bone scan studies.

    Directory of Open Access Journals (Sweden)

    Aung Zaw Win

    Full Text Available Cancer and metabolic bone diseases can alter the SUV. SUV values have never been measured from healthy skeletons in NaF18-PET/CT bone scans. The primary aim of this study was to measure the SUV values from normal skeletons in NaF18-PET/CT bone scans.A retrospective study was carried out involving NaF18- PET/CT bone scans that were done at our institution between January 2010 to May 2012. Our excluding criteria was patients with abnormal real function and patients with past history of cancer and metabolic bone diseases including but not limited to osteoporosis, osteopenia and Paget's disease. Eleven studies met all the criteria.The average normal SUVmax values from 11 patients were: cervical vertebrae 6.84 (range 4.38-8.64, thoracic vertebrae 7.36 (range 6.99-7.66, lumbar vertebrae 7.27 (range 7.04-7.72, femoral head 2.22 (range 1.1-4.3, humeral head 1.82 (range 1.2-2.9, mid sternum 5.51 (range 2.6-8.1, parietal bone 1.71 (range 1.3-2.4.According to our study, various skeletal sites have different normal SUV values. SUV values can be different between the normal bones and bones with tumor or metabolic bone disease. SUV can be used to quantify NaF-18 PET/CT studies. If the SUV values of the normal skeleton are known, they can be used in the characterization of bone lesions and in the assessment of treatment response to bone diseases.

  12. Functional coupling of renal K+ and Na+ handling causes high blood pressure in Na+ replete mice.

    Science.gov (United States)

    Vitzthum, Helga; Seniuk, Anika; Schulte, Laura Helene; Müller, Maxie Luise; Hetz, Hannah; Ehmke, Heimo

    2014-03-01

    A network of kinases, including WNKs, SPAK and Sgk1, is critical for the independent regulation of K+ and Na+ transport in the distal nephron. Angiotensin II is thought to act as a key hormone in orchestrating these kinases to switch from K+ secretion during hyperkalaemia to Na+ reabsorption during intravascular volume depletion, thus keeping disturbances in electrolyte and blood pressure homeostasis at a minimum. It remains unclear, however, how K+ and Na+ transport are regulated during a high Na+ intake, which is associated with suppressed angiotensin II levels and a high distal tubular Na+ load. We therefore investigated the integrated blood pressure, renal, hormonal and gene and protein expression responses to large changes of K+ intake in Na+ replete mice. Both low and high K+ intake increased blood pressure and caused Na+ retention. Low K+ intake was accompanied by an upregulation of the sodium-chloride cotransporter (NCC) and its activating kinase SPAK, and inhibition of NCC normalized blood pressure. Renal responses were unaffected by angiotensin AT1 receptor antagonism, indicating that low K+ intake activates the distal nephron by an angiotensin-independent mode of action. High K+ intake was associated with elevated plasma aldosterone concentrations and an upregulation of the epithelial sodium channel (ENaC) and its activating kinase Sgk1. Surprisingly, high K+ intake increased blood pressure even during ENaC or mineralocorticoid receptor antagonism, suggesting the contribution of aldosterone-independent mechanisms. These findings show that in a Na+ replete state, changes in K+ intake induce specific molecular and functional adaptations in the distal nephron that cause a functional coupling of renal K+ and Na+ handling, resulting in Na+ retention and high blood pressure when K+ intake is either restricted or excessively increased.

  13. Recent results from NA61/SHINE

    CERN Document Server

    Kowalski, Seweryn

    2015-01-01

    The aim of the NA61/SHINE ion programme is to explore the QCD phase diagram within the range of thermodynamical variables accessible by the SPS. Moreover the experiment provides precision hadron production measurements to improve computation of neutrino fluxes in neutrino oscillation experiments and for improving air shower simulations of cosmic-ray experiments. The main physics goals of the NA61/SHINE ion programme are the study of the properties of the onset of deconfinement and the search for signatures of the critical point of strongly interacting matter. These goals are pursued by performing an energy (beam momentum 13A – 158 A GeV/c) and system size (p+p, p+Pb, Be+Be, Ar+Sc, Xe+La) scan. This paper reviews the status and results of the NA61/SHINE experiment.

  14. Eletrencefalograma na síndrome parkinsoniana

    Directory of Open Access Journals (Sweden)

    José Geraldo Camargo Lima

    1973-09-01

    Full Text Available Foram estudados os eletrencefalogramas de 50 pacientes parkinsonianos livres de qualquer antecedente convulsivo, sendo registrados traçados anormais em 40% dos casos. A incidência de traçados anormais foi maior na síndrome parkinsoniana bilateral do que na unilateral (52% e 25%, respectivamente. Entre as anormalidades assinaladas foram as paroxísticas as mais freqüentes (65% dos casos, caracterizando-se predominantemente por surtos de ondas teta. O registro de anormalidades paroxísticas do tipo irritativo encontrado em três casos é salientado. Alterações da atividade de base foram assinaladas em 35% dos pacientes. A idade dos pacientes não parece ter tido importante papel na gênese das anormalidades eletrencefalográficas.

  15. Tecnologia simplificada na enfermagem materno infantil

    Directory of Open Access Journals (Sweden)

    Selma Campestrini

    1991-09-01

    Full Text Available A autora apresenta três modelos de tecnologia simplificada da enfermagem materno infantil: o equipamento didático SEIO COBAIA para treinar exercícios e massagens da mama e mamilo; a peça indumentária SUPRETRAUMA - sutiã preventivo de traumatismo mamilar - usado por gestantes; e, a técnica para reverter mamilo umbilicado durante o puerperio imediato. Além de corroborar na promoção do aleitamento materno e na prevenção de desmame precoce, demonstra a possibilidade da enfermagem relacionar o saber teórico-científico com o saber tecnico-prático, na saúde da mulher e da criança, com tecnologia adequada às necessidades, à compreensão e ao bem estar da população.

  16. Labirintos na cidade contemporânea

    Directory of Open Access Journals (Sweden)

    Edson Luiz André de Sousa

    Full Text Available Este artigo pretende tensionar pontos de conexão e diluição de fronteiras entre as categorias público/privado, conversando com a literatura de Baudelaire e W. Benjamin, Fredric Jamenson e Marc Augé. Através da imagem do labirinto, símbolo da cidade antiga que se quis extinguir na cidade moderna, busca-se refletir sobre alguns caminhos e caminhantes considerados excedentes na cidade contemporânea. O cenário propulsor dessa reflexão é a experiência do jornal Boca de Rua, elaborado por moradores de rua na cidade de Porto Alegre.

  17. Rastreabilidade de componentes na cadeia de fornecimento

    OpenAIRE

    2005-01-01

    Como pouco se conhece sobre a aplicação e uso da tecnologia de RFID (Identificação por rádio frequência) na Identificação automática e recolha e dados de componentes na cadeia de fornecimento num contexto de rastreabilidade, o presente trabalho visa procurar conhecer melhor os fenómenos em estudo através de novas questões, novas explicações, tentando indagar as características e as alterações que esta tecnologia irá provocar na gestão da cadeia de fornecimento. A cadeia d...

  18. Knjige o kartografskim projekcijama na internetu

    Directory of Open Access Journals (Sweden)

    Nedjeljko Frančula

    2011-12-01

    Full Text Available U ovom prikazu skrećemo pozornost na neke knjige o kartografskim projekcijama koje su prvobitno objavljene u tisku, a potom digitalizirane i besplatno stavljene na mrežu. Neke od tih knjiga nude se na mreži kao Google e-knjige. Google godinama skuplja knjige kojima su istekla autorska prava i digitalizira ih. Fotografira se svaka stranica te zatim spaja u jednu veliku fotografiju iz koje se izvlači tekst softverom OCR. Google čuva originalnu digitalnu fotografiju u svom arhivu, a izvučeni tekst pretvara u formate HTML, PDF ili EPUB. Google danas nudi više od milijun besplatnih e-knjiga (http://www.google.com/books.

  19. Aponecrotic, antiangiogenic and antiproliferative effects of a novel dextran derivative on breast cancer growth in vitro and in vivo

    OpenAIRE

    Benedetto, Mélanie Di; Starzec, Anna; Colombo, Bruno M; Briane, Dominique; Perret, Gérard Y; Kraemer, Michel; Crépin, Michel

    2002-01-01

    1 Since the sodium phenylacetate (NaPa) was reported to enhance the inhibitory effect of carboxymethyl benzylamide dextran (CMDB) on the breast cancer growth, we performed the esterification of CMDB with NaPa to obtain a new drug carrying the characteristics of these two components. A new molecule, phenylacetate carboxymethyl benzylamide dextran, was named NaPaC.We investigated in vitro and in vivo the effects of NaPaC on MCF-7ras cell growth as well as its apoptotic and antiangiogenic effect...

  20. Diabetes and pancreatic cancer

    OpenAIRE

    Christine Hsu; Muhammad Wasif Saif

    2012-01-01

    Pancreatic cancer is the fourth leading cause of cancer death in the United States. Risk factors for pancreatic cancer are smoking, family history, chronic pancreatitis, and diabetes. There is controversy with regards to the causal relationship between diabetes and pancreatic cancer because many patients with pancreatic cancer have new onset diabetes. Abstracts presented at the 2011 American Society of Clinical Oncology (ASCO) Annual Meeting highlighted and supported the positive association ...