Focal low-dose rate brachytherapy for the treatment of prostate cancer

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Tong WY

2013-09-01

Full Text Available William Y Tong, Gilad Cohen, Yoshiya Yamada Memorial Sloan-Kettering Cancer Center, Department of Radiation Oncology, New York, NY, USA Abstract: Whole-gland low-dose rate (LDR brachytherapy has been a well-established modality of treating low-risk prostate cancer. Treatment in a focal manner has the advantages of reduced toxicity to surrounding organs. Focal treatment using LDR brachytherapy has been relatively unexplored, but it may offer advantages over other modalities that have established experiences with a focal approach. This is particularly true as prostate cancer is being detected at an earlier and more localized stage with the advent of better detection methods and newer imaging modalities. Keywords: prostate cancer, focal, low dose rate, brachytherapy

History of International Workshop on Mini-Micro- and Nano- Dosimetry (MMND) and Innovation Technologies in Radiation Oncology (ITRO)

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Rosenfeld, Anatoly B.; Zaider, Marco; Yamada, Josh; Zelefsky, Michael J.

2017-01-01

The biannual MMND (former MMD) - IPCT workshops was founded in collaboration between the Centre for Medical Radiation Physics, University of Wollongong and the Memorial Sloan Kettering Cancer Center (MSKCC) in 2001 and has become an important international multidisciplinary forum for the discussion of advanced quality assurance (QA) dosimetry technology for radiation therapy and space science, as well as advanced technologies for clinical cancer treatment.

2015 Soft Condensed Matter Physics: Self-Assembly and Active Matter GRC/GRS

Science.gov (United States)

2015-10-20

Broad Institute of MIT and Harvard Poster Presenter Registered Beller, Daniel A Harvard University Poster Presenter Registered Bi, Dapeng Syracuse...Poster Presenter Registered Deforet, Maxime Memorial Sloan Kettering Cancer Center Poster Presenter Registered Del Gado, Emanuela Georgetown...Registered Dullens, Roel University of Oxford Poster Presenter Registered Fakhri, Nikta MIT Poster Presenter Registered Fan, Jing Harvard

Targeting BRCAness in Gastric Cancer

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2017-10-01

Award Number: W81XWH-16-1-0470 TITLE: Targeting BRCAness in Gastric Cancer PRINCIPAL INVESTIGATOR: Yelena Janjigian CONTRACTING ORGANIZATION...Sloan-Kettering Institute for Cancer Research New York, NY 10065 REPORT DATE: October 2017 TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical...Targeting BRCAness in Gastric Cancer 5b. GRANT NUMBER W81XWH-16-1-0473 (Ashworth) 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Eric Collisson, David

CheckMate 025 Randomized Phase 3 Study: Outcomes by Key Baseline Factors and Prior Therapy for Nivolumab Versus Everolimus in Advanced Renal Cell Carcinoma

DEFF Research Database (Denmark)

Escudier, Bernard; Sharma, Padmanee; McDermott, David F

2017-01-01

/kg every 2 wk or everolimus 10mg once daily. RESULTS AND LIMITATIONS: The minimum follow-up was 14 mo. Baseline subgroup distributions were balanced between nivolumab and everolimus arms. Nivolumab demonstrated an OS improvement versus everolimus across subgroups, including Memorial Sloan Kettering Cancer...... Center (MSKCC) and International Metastatic Renal Cell Carcinoma Database Consortium risk groups; age

Precision Oncology and Genetic Risk Information: Exploring Patients' Preferences and Responses

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Dr. Jada Hamilton is an Assistant Member at Memorial Sloan Kettering Cancer Center, as well as an Assistant Attending Psychologist in the Behavioral Sciences Service, Department of Psychiatry and Behavioral Sciences and in the Clinical Genetics Service, Department of Medicine at Memorial Hospital in New York, New York.  She leads a program of research at the intersection of behavioral science, cancer prevention, and genomics, with the goal of translating advances in genetic and genomic medicine into improved cancer care that is of high quality, aligned with patient preferences, and ultimately improves public health.  Dr. Hamilton is also currently leading a study to assess how patients and their families respond to inherited risk information that is revealed as part of tumor sequencing (funded through a Mentored Research Scholar Grant from the American Cancer Society), as well as studies to evaluate alternative models for offering genetic counseling and testing to patients with cancer, and to examine the effects of novel breast cancer genetic risk feedback on patients’ decision-making, psychological, and behavioral outcomes. Prior to joining the faculty of Memorial Sloan Kettering, Dr. Hamilton received a BA in Genetics and Psychology from Ohio Wesleyan University (2004), an MA and PhD in Social and Health Psychology from Stony Brook University (2006, 2009), and an MPH from the Mailman School of Public Health at Columbia University (2010).  She also completed a postdoctoral fellowship as part of the National Cancer Institute’s Cancer Prevention Fellowship Program.

Development of Medical Technology for Contingency Response to Marrow Toxic Agents

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2014-05-06

Specific Oligonucleotides SSP Sequence Specific Primers SSOP Sequence Specific Oligonucleotide Probes STAR ® Search, Tracking and Registry TBI Total... white paper detailing recommendations/guidelines for the assessment of new assays (potency or other assays) relevant to cord blood banking and/or...Irradiation - Marcel van den Brink (Memorial Sloan Kettering Cancer Center) 5. Organ Toxicity: h. Pulmonary Toxicity - Zeljko Vujaskovic (Duke) i

Impact of immune parameters on long-term survival in metastatic renal cell      carcinoma

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Donskov, Frede; Maase, Hans von der

2006-01-01

with estimated       5-year survival rates of 60%, 25%, and 0%, respectively. These findings       were apparent in both our own prognostic model and in an extended Memorial       Sloan-Kettering Cancer Center (New York, NY) prognostic model. CONCLUSION:       This study points on five clinical and three...

Dynamic contrast-enhanced computed tomography as a potential biomarker in patients with metastatic renal cell carcinoma: preliminary results from the Danish Renal Cancer Group Study-1

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Mains, Jill Rachel; Donskov, Frede; Pedersen, Erik Morre

2014-01-01

OBJECTIVES: The aim of this study was to explore the impact of dynamic contrast-enhanced (DCE) computer tomography (CT) as a biomarker in metastatic renal cell carcinoma (mRCC). MATERIALS AND METHODS: Twelve patients with favorable or intermediate Memorial Sloan Kettering Cancer Center risk group...... blinded to treatment group. The DCE-CT scans were performed at baseline, at weeks 5 and 10, and thereafter every third month. Blood flow (BF; mL/min/100 mL), peak enhancement (Hounsfield units), time to peak (seconds), and blood volume (BV; mL/100 g) were calculated. Parameters for DCE-CT were correlated...

ERF is a Potential ERK-Modulated Tumor Suppressor in Prostate Cancer

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2017-10-01

AWARD NUMBER: W81XWH-15-1-0277 TITLE: ERF is a Potential ERK-Modulated Tumor Suppressor in Prostate Cancer PRINCIPAL INVESTIGATOR: Dr...Rohit Bose CONTRACTING ORGANIZATION: Sloan Kettering Institute for Cancer Research New York NY 10065 REPORT DATE: October 2017 TYPE OF REPORT...4. TITLE AND SUBTITLE ERF is a Potential ERK-Modulated Tumor Suppressor in Prostate Cancer 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-15-1-0277 5c

Introducing a music program in the perioperative area.

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Cunningham, M F; Monson, B; Bookbinder, M

1997-10-01

Music can touch patients deeply and thus transform their anxiety and stress into relaxation and healing. Patients with cancer who undergo surgical procedures are highly stressed. To help alleviate these patients' stress and improve their comfort, perioperative nurses at Memorial Sloan-Kettering Cancer Center (MSKCC), New York, surveyed surgical patients and staff members about introducing a perioperative music program. This article reviews the literature on the use of music in perioperative care settings and describes MSKCC's decision to evaluate and then implement a music program.

Exploring cell apoptosis and senescence to understand and treat cancer: an interview with Scott Lowe

Directory of Open Access Journals (Sweden)

2015-11-01

Full Text Available Scott W. Lowe is currently principal investigator at the Memorial Sloan-Kettering Cancer Center. After beginning his studies in chemical engineering, he decided to take another path and became fascinated by biochemistry, genetics and molecular biology, which ultimately led to an interest in human disease, particularly cancer. During his PhD at the Massachusetts Institute of Technology (MIT, Scott had the opportunity to benefit from the exceptional mentorship of Earl Ruley, David Housman and Tyler Jacks, and contributed to elucidating how the p53 (TP53 tumor suppressor gene limits oncogenic transformation and modulates the cytotoxic response to conventional chemotherapy. This important work earned him a fellowship from the Cold Spring Harbor Laboratory, which helped to launch his independent career. Scott is now a leading scientist in the cancer field and his work has helped to shed light on mechanisms of cell apoptosis and senescence to better understand and treat cancer. In this interview, he talks about this incredible scientific journey.

Evolving technologies drive the new roles of Biomedical Engineering.

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Frisch, P H; St Germain, J; Lui, W

2008-01-01

Rapidly changing technology coupled with the financial impact of organized health care, has required hospital Biomedical Engineering organizations to augment their traditional operational and business models to increase their role in developing enhanced clinical applications utilizing new and evolving technologies. The deployment of these technology based applications has required Biomedical Engineering organizations to re-organize to optimize the manner in which they provide and manage services. Memorial Sloan-Kettering Cancer Center has implemented a strategy to explore evolving technologies integrating them into enhanced clinical applications while optimally utilizing the expertise of the traditional Biomedical Engineering component (Clinical Engineering) to provide expanded support in technology / equipment management, device repair, preventive maintenance and integration with legacy clinical systems. Specifically, Biomedical Engineering is an integral component of the Medical Physics Department which provides comprehensive and integrated support to the Center in advanced physical, technical and engineering technology. This organizational structure emphasizes the integration and collaboration between a spectrum of technical expertise for clinical support and equipment management roles. The high cost of clinical equipment purchases coupled with the increasing cost of service has driven equipment management responsibilities to include significant business and financial aspects to provide a cost effective service model. This case study details the dynamics of these expanded roles, future initiatives and benefits for Biomedical Engineering and Memorial Sloan Kettering Cancer Center.

Exploring cell apoptosis and senescence to understand and treat cancer: an interview with Scott Lowe.

Science.gov (United States)

Lowe, Scott; Cifra, Alessandra

2015-11-01

Scott W. Lowe is currently principal investigator at the Memorial Sloan-Kettering Cancer Center. After beginning his studies in chemical engineering, he decided to take another path and became fascinated by biochemistry, genetics and molecular biology, which ultimately led to an interest in human disease, particularly cancer. During his PhD at the Massachusetts Institute of Technology (MIT), Scott had the opportunity to benefit from the exceptional mentorship of Earl Ruley, David Housman and Tyler Jacks, and contributed to elucidating how the p53 (TP53) tumor suppressor gene limits oncogenic transformation and modulates the cytotoxic response to conventional chemotherapy. This important work earned him a fellowship from the Cold Spring Harbor Laboratory, which helped to launch his independent career. Scott is now a leading scientist in the cancer field and his work has helped to shed light on mechanisms of cell apoptosis and senescence to better understand and treat cancer. In this interview, he talks about this incredible scientific journey. © 2015. Published by The Company of Biologists Ltd.

Translational Bioinformatics and Clinical Research (Biomedical) Informatics.

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Sirintrapun, S Joseph; Zehir, Ahmet; Syed, Aijazuddin; Gao, JianJiong; Schultz, Nikolaus; Cheng, Donavan T

2015-06-01

Translational bioinformatics and clinical research (biomedical) informatics are the primary domains related to informatics activities that support translational research. Translational bioinformatics focuses on computational techniques in genetics, molecular biology, and systems biology. Clinical research (biomedical) informatics involves the use of informatics in discovery and management of new knowledge relating to health and disease. This article details 3 projects that are hybrid applications of translational bioinformatics and clinical research (biomedical) informatics: The Cancer Genome Atlas, the cBioPortal for Cancer Genomics, and the Memorial Sloan Kettering Cancer Center clinical variants and results database, all designed to facilitate insights into cancer biology and clinical/therapeutic correlations. Copyright © 2015 Elsevier Inc. All rights reserved.

Risk factors and classifications of hilar cholangiocarcinoma.

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Suarez-Munoz, Miguel Angel; Fernandez-Aguilar, Jose Luis; Sanchez-Perez, Belinda; Perez-Daga, Jose Antonio; Garcia-Albiach, Beatriz; Pulido-Roa, Ysabel; Marin-Camero, Naiara; Santoyo-Santoyo, Julio

2013-07-15

Cholangiocarcinoma is the second most common primary malignant tumor of the liver. Perihilar cholangiocarcinoma or Klatskin tumor represents more than 50% of all biliary tract cholangiocarcinomas. A wide range of risk factors have been identified among patients with Perihilar cholangiocarcinoma including advanced age, male gender, primary sclerosing cholangitis, choledochal cysts, cholelithiasis, cholecystitis, parasitic infection (Opisthorchis viverrini and Clonorchis sinensis), inflammatory bowel disease, alcoholic cirrhosis, nonalcoholic cirrhosis, chronic pancreatitis and metabolic syndrome. Various classifications have been used to describe the pathologic and radiologic appearance of cholangiocarcinoma. The three systems most commonly used to evaluate Perihilar cholangiocarcinoma are the Bismuth-Corlette (BC) system, the Memorial Sloan-Kettering Cancer Center and the TNM classification. The BC classification provides preoperative assessment of local spread. The Memorial Sloan-Kettering cancer center proposes a staging system according to three factors related to local tumor extent: the location and extent of bile duct involvement, the presence or absence of portal venous invasion, and the presence or absence of hepatic lobar atrophy. The TNM classification, besides the usual descriptors, tumor, node and metastases, provides additional information concerning the possibility for the residual tumor (R) and the histological grade (G). Recently, in 2011, a new consensus classification for the Perihilar cholangiocarcinoma had been published. The consensus was organised by the European Hepato-Pancreato-Biliary Association which identified the need for a new staging system for this type of tumors. The classification includes information concerning biliary or vascular (portal or arterial) involvement, lymph node status or metastases, but also other essential aspects related to the surgical risk, such as remnant hepatic volume or the possibility of underlying disease.

Development and Assessment of Memorial Sloan Kettering Cancer Center’s Surgical Secondary Events Grading System

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Strong, Vivian E.; Selby, Luke V.; Sovel, Mindy; Disa, Joseph J.; Hoskins, William; DeMatteo, Ronald; Scardino, Peter; Jaques, David P.

2015-01-01

Background Studying surgical secondary events is an evolving effort with no current established system for database design, standard reporting, or definitions. Using the Clavien-Dindo classification as a guide, in 2001 we developed a Surgical Secondary Events database based on grade of event and required intervention to begin prospectively recording and analyzing all surgical secondary events (SSE). Study Design Events are prospectively entered into the database by attending surgeons, house staff, and research staff. In 2008 we performed a blinded external audit of 1,498 operations that were randomly selected to examine the quality and reliability of the data. Results 1,498 of 4,284 operations during the 3rd quarter of 2008 were audited. 79% (N=1,180) of the operations did not have a secondary event while 21% (N=318) of operations had an identified event. 91% (1,365) of operations were correctly entered into the SSE database. 97% (129/133) of missed secondary events were Grades I and II. Three Grade III (2%) and one Grade IV (1%) secondary event were missed. There were no missed Grade 5 secondary events. Conclusion Grade III – IV events are more accurately collected than Grade I – II events. Robust and accurate secondary events data can be collected by clinicians and research staff and these data can safely be used for quality improvement projects and research. PMID:25319579

Predictors of Bowel Function in Long-term Rectal Cancer Survivors with Anastomosis.

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Alavi, Mubarika; Wendel, Christopher S; Krouse, Robert S; Temple, Larissa; Hornbrook, Mark C; Bulkley, Joanna E; McMullen, Carmit K; Grant, Marcia; Herrinton, Lisa J

2017-11-01

Bowel function in long-term rectal cancer survivors with anastomosis has not been characterized adequately. We hypothesized that bowel function is associated with patient, disease, and treatment characteristics. The cohort study included Kaiser Permanente members who were long-term (≥5 years) rectal cancer survivors with anastomosis. Bowel function was scored using the self-administered, 14-item Memorial Sloan-Kettering Cancer Center Bowel Function Index. Patient, cancer, and treatment variables were collected from the electronic medical chart. We used multiple regression to assess the relationship of patient- and treatment-related variables with the bowel function score. The study included 381 anastomosis patients surveyed an average 12 years after their rectal cancer surgeries. The total bowel function score averaged 53 (standard deviation, 9; range, 31-70, higher scores represent better function). Independent factors associated with worse total bowel function score included receipt of radiation therapy (yes vs. no: 5.3-unit decrement, p 6 cm: 3.2-unit decrement, p decrement, p decrement, p model explained 20% of the variation in the total bowel function score. Low tumor location, radiation therapy, temporary ostomy during initial treatment, and history of smoking were linked with decreased long-term bowel function following an anastomosis. These results should improve decision-making about surgical options.

Performance of a Nomogram Predicting Disease-Specific Survival After an R0 Resection for Gastric Cancer in Patients Receiving Postoperative Chemoradiation Therapy

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Dikken, Johan L. [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Department of Surgery, Leiden University Medical Center, Leiden (Netherlands); Coit, Daniel G. [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Baser, Raymond E.; Gönen, Mithat [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Goodman, Karyn A. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Brennan, Murray F. [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Jansen, Edwin P.M. [Department of Radiotherapy, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Boot, Henk [Department of Gastroenterology, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Velde, Cornelis J.H. van de [Department of Surgery, Leiden University Medical Center, Leiden (Netherlands); Cats, Annemieke [Department of Gastroenterology, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Verheij, Marcel, E-mail: m.verheij@nki.nl [Department of Radiotherapy, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)

2014-03-01

Purpose: The internationally validated Memorial Sloan-Kettering Cancer Center (MSKCC) gastric carcinoma nomogram was based on patients who underwent curative (R0) gastrectomy, without any other therapy. The purpose of the current study was to assess the performance of this gastric cancer nomogram in patients who received chemoradiation therapy after an R0 resection for gastric cancer. Methods and Materials: In a combined dataset of 76 patients from the Netherlands Cancer Institute (NKI), and 63 patients from MSKCC, who received postoperative chemoradiation therapy (CRT) after an R0 gastrectomy, the nomogram was validated by means of the concordance index (CI) and a calibration plot. Results: The concordance index for the nomogram was 0.64, which was lower than the CI of the nomogram for patients who received no adjuvant therapy (0.80). In the calibration plot, observed survival was approximately 20% higher than the nomogram-predicted survival for patients receiving postoperative CRT. Conclusions: The MSKCC gastric carcinoma nomogram significantly underpredicted survival for patients in the current study, suggesting an impact of postoperative CRT on survival in patients who underwent an R0 resection for gastric cancer, which has been demonstrated by randomized controlled trials. This analysis stresses the need for updating nomograms with the incorporation of multimodal strategies.

Radiation therapy of Kaposi's sarcoma in AIDS: Memorial Sloan-Kettering experience

International Nuclear Information System (INIS)

Nisce, L.Z.; Safai, B.

1985-01-01

In 1980 the authors reported their experience in the management of Kaposi's sarcoma (KS) affecting elderly men of Jewish or Italian descent. Since the outbreak of KS in 1981 among young male homosexuals with acquired immune deficiency syndrome (AIDS) the KS in the elderly has been subsequently called classical Kaposi's sarcome (CKS) in order to differentiate it from the KS in AIDS. The radiosensitivity of CKS is well documented. This report describes the authors' early experience in the radiation therapy of KS in AIDS compared with CKS and also discusses the problems related to the irradiation of the immunocompromised patient

Screening for thyroid cancer in survivors of childhood and young adult cancer treated with neck radiation.

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Tonorezos, Emily S; Barnea, Dana; Moskowitz, Chaya S; Chou, Joanne F; Sklar, Charles A; Elkin, Elena B; Wong, Richard J; Li, Duan; Tuttle, R Michael; Korenstein, Deborah; Wolden, Suzanne L; Oeffinger, Kevin C

2017-06-01

The optimal method of screening for thyroid cancer in survivors of childhood and young adult cancer exposed to neck radiation remains controversial. Outcome data for a physical exam-based screening approach are lacking. We conducted a retrospective review of adult survivors of childhood and young adult cancer with a history of neck radiation followed in the Adult Long-Term Follow-Up Clinic at Memorial Sloan Kettering between November 2005 and August 2014. Eligible patients underwent a physical exam of the thyroid and were followed for at least 1 year afterwards. Ineligible patients were those with prior diagnosis of benign or malignant thyroid nodules. During a median follow-up of 3.1 years (range 0-9.4 years), 106 ultrasounds and 2277 physical exams were performed among 585 patients. Forty survivors had an abnormal thyroid physical exam median of 21 years from radiotherapy; 50% of those with an abnormal exam were survivors of Hodgkin lymphoma, 60% had radiation at ages 10-19, and 53% were female. Ultimately, 24 underwent fine needle aspiration (FNA). Surgery revealed papillary carcinoma in seven survivors; six are currently free of disease and one with active disease is undergoing watchful waiting. Among those with one or more annual visits, representing 1732 person-years of follow-up, no cases of thyroid cancer were diagnosed within a year of normal physical exam. These findings support the application of annual physical exam without routine ultrasound for thyroid cancer screening among survivors with a history of neck radiation. Survivors with a history of neck radiation may not require routine thyroid ultrasound for thyroid cancer screening. Among adult survivors of childhood and young adult cancer with a history of radiation therapy to the neck, annual physical exam is an acceptable thyroid cancer screening strategy.

Electroplating targets for production of unique PET radionuclides

International Nuclear Information System (INIS)

Bui, V.; Sheh, Y.; Finn, R.

1994-01-01

The past decade has witnessed the applications of Positron Emission Tomography (PET) evolving from a purely research endeavour to a procedure which has specific clinical applications in the areas of cardiology, neurology and oncology. The growth of PET has been facilitated by developments in medical instrumentation and radiopharmaceutical chemistry efforts. Included in this latter effort has been the low energy accelerator production and processing of unique PET radionuclides appropriate for the radiolabeling of biomolecules i.e. monoclonal antibodies and pepetides. The development and application of electroplated targets of antimony and copper for the production of iodine-124 and gallium-66 respectively, utilizing the Memorial Sloan-Kettering Cancer Center cyclotron are examples of target design and development applicable to many medical accelerators

The state of the art in therapeutic nuclear medicine

International Nuclear Information System (INIS)

Allen, B.J.

2001-01-01

Radionuclide therapy can be curative or palliative in intent, and local or systemic in administration. Current therapy relies of beta emitting radioisotopes and selective carriers for the treatment of advanced tumours. The next generation of therapeutics may be alpha emitting radionuclides for subclinical, micrometastatic disease. Targeted Alpha therapy (TAT) offers the potential to inhibit the growth of micrometastases by selectively killing isolated and preangiogenic clusters of cancer cells. The practicality and efficacy of TAT has been tested by in vitro and in vivo studies many cancers. The first phase 1 clinical trial of TAT for leukaemia with Bi-213 has concluded at the Memorial Sloan Kettering Cancer Center, a phase 1 and 2 trial of intra-lesional TAT is ongoing at Duke University with At-211 labeled Mab against cystic glioma, and a phase 1 and 2 clinical trial for intra-lesional TAT with Bi-213 of subcutaneous secondary melanoma is underway at St George Hospital

Electronic patient self-assessment and management (SAM): a novel framework for cancer survivorship.

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Vickers, Andrew J; Salz, Talya; Basch, Ethan; Cooperberg, Matthew R; Carroll, Peter R; Tighe, Foss; Eastham, James; Rosen, Raymond C

2010-06-17

We propose a novel framework for management of cancer survivorship: electronic patient Self-Assessment and Management (SAM). SAM is a framework for transfer of information to and from patients in such a way as to increase both the patient's and the health care provider's understanding of the patient's progress, and to help ensure that patient care follows best practice. Patients who participate in the SAM system are contacted by email at regular intervals and asked to complete validated questionnaires online. Patient responses on these questionnaires are then analyzed in order to provide patients with real-time, online information about their progress and to provide them with tailored and standardized medical advice. Patient-level data from the questionnaires are ported in real time to the patient's health care provider to be uploaded to clinic notes. An initial version of SAM has been developed at Memorial Sloan-Kettering Cancer Center (MSKCC) and the University of California, San Francisco (UCSF) for aiding the clinical management of patients after surgery for prostate cancer. Pilot testing at MSKCC and UCSF suggests that implementation of SAM systems are feasible, with no major problems with compliance (> 70% response rate) or security. SAM is a conceptually simple framework for passing information to and from patients in such a way as to increase both the patient's and the health care provider's understanding of the patient's progress, and to help ensure that patient care follows best practice.

Electronic patient self-assessment and management (SAM: a novel framework for cancer survivorship

Directory of Open Access Journals (Sweden)

Tighe Foss

2010-06-01

Full Text Available Abstract Background We propose a novel framework for management of cancer survivorship: electronic patient Self-Assessment and Management (SAM. SAM is a framework for transfer of information to and from patients in such a way as to increase both the patient's and the health care provider's understanding of the patient's progress, and to help ensure that patient care follows best practice. Methods Patients who participate in the SAM system are contacted by email at regular intervals and asked to complete validated questionnaires online. Patient responses on these questionnaires are then analyzed in order to provide patients with real-time, online information about their progress and to provide them with tailored and standardized medical advice. Patient-level data from the questionnaires are ported in real time to the patient's health care provider to be uploaded to clinic notes. An initial version of SAM has been developed at Memorial Sloan-Kettering Cancer Center (MSKCC and the University of California, San Francisco (UCSF for aiding the clinical management of patients after surgery for prostate cancer. Results Pilot testing at MSKCC and UCSF suggests that implementation of SAM systems are feasible, with no major problems with compliance (> 70% response rate or security. Conclusion SAM is a conceptually simple framework for passing information to and from patients in such a way as to increase both the patient's and the health care provider's understanding of the patient's progress, and to help ensure that patient care follows best practice.

Cancer surgeons' distress and well-being, II: modifiable factors and the potential for organizational interventions.

Science.gov (United States)

Guest, Rebecca S; Baser, Ray; Li, Yuelin; Scardino, Peter T; Brown, Arthur E; Kissane, David W

2011-05-01

We showed in a companion paper that the prevalence of burnout among surgical oncologists at a comprehensive cancer center was 42% and psychiatric morbidity 27%, and high quality of life (QOL) was absent for 54% of surgeons. Here we examine modifiable workplace factors and other stressors associated with burnout, psychiatric morbidity, and low QOL, together with interest in interventions to reduce distress and improve wellness. Study-specific questions important for morale, QOL, and stressors associated with burnout were included in an anonymous Internet-based survey distributed to the surgical faculty at Memorial Sloan-Kettering Cancer Center. Among the 72 surgeons who responded (response rate of 73%), surgeons identified high stress from medical lawsuits, pressure to succeed in research, financial worries, negative attitudes to gender, and ability to cope with patients' suffering and death. Workplace features requiring greatest change were the reimbursement system, administrative support, and schedule. Work-life balance and relationship issues with spouse or partner caused high stress. Strongest correlations with distress were a desire to change communication with patients and the tension between the time devoted to work versus time available to be with family. Surgeons' preferences for interventions favored a fitness program, nutrition consultation, and increased socialization with colleagues, with less interest in interventions conventionally used to address psychological distress. Several opportunities to intervene at the organizational level permit efforts to reduce burnout and improve QOL.

The relative value of cytometry and cytology in the management of bladder cancer: the Memorial Sloan-Kettering Cancer Center experience.

Science.gov (United States)

Badalament, R A; Fair, W R; Whitmore, W F; Melamed, M R

1988-02-01

The flow cytometric studies presented herein are based almost entirely on DNA measurements and represent an early application of this diagnostic test. Nevertheless, the MSKCC experience with FCM has demonstrated that it is technically feasible and clinically useful. The sensitivity of FCM is in the range of 80% to 85% overall, and is superior to that of conventional voided or bladder wash cytology. In the absence of inflammation secondary to infection, calculi, or intravesical agents such as BCG, the specificity is greater than 90%. In the presence of inflammation, FCM appears to be less specific than conventional cytology. A potential advantage of FCM over cytology is the quantitative nature of the examination permitting comparisons of sequential examinations. Also, there are refinements in technique that hold promise of increasing the accuracy or clinical usefulness of FCM, eg, the joint measurements of DNA and differentiation antigens defined by monoclonal antibodies. Yet, despite the current and potential advantages of FCM, voided urinary cytology continues to be the procedure of choice for detection and monitoring urothelial carcinoma, not only because of our long experience and better understanding of this test, but because of its proven high specificity, because it is noninvasive, widely available, and may help to detect upper tract or urethral tumors.

Low-dose-rate brachytherapy for patients with transurethral resection before implantation in prostate cancer: long-term results

International Nuclear Information System (INIS)

Prada, Pedro J.; Anchuelo, Javier; Blanco, Ana Garcia; Paya, Gema; Cardenal, Juan; Acuña, Enrique; Ferri, Maria; Vazquez, Andres; Pacheco, Maite; Sanchez, Jesica

2016-01-01

Objectives: We analyzed the long-term oncologic outcome for patients with prostate cancer and transurethral resection who were treated using low-dose-rate (LDR) prostate brachytherapy. Methods and Materials: From January 2001 to December 2005, 57 consecutive patients were treated with clinically localized prostate cancer. No patients received external beam radiation. All of them underwent LDR prostate brachytherapy. Biochemical failure was defined according to the 'Phoenix consensus'. Patients were stratified as low and intermediate risk based on The Memorial Sloan Kettering group definition. Results: The median follow-up time for these 57 patients was 104 months. The overall survival according to Kaplan-Meier estimates was 88% (±6%) at 5 years and 77% (±6%) at 12 years. The 5 and 10 years for failure in tumour-free survival (TFS) was 96% and respectively (±2%), whereas for biochemical control was 94% and respectively (±3%) at 5 and 10 years, 98% (±1%) of patients being free of local recurrence. A patient reported incontinence after treatment (1.7%). The chronic genitourinary complains grade I were 7% and grade II, 10%. At six months 94% of patients reported no change in bowel function. Conclusions: The excellent long-term results and low morbidity presented, as well as the many advantages of prostate brachytherapy over other treatments, demonstrates that brachytherapy is an effective treatment for patients with transurethral resection and clinical organ-confined prostate cancer. (author)

Low-dose-rate brachytherapy for patients with transurethral resection before implantation in prostate cancer: long-term results

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Prada, Pedro J.; Anchuelo, Javier; Blanco, Ana Garcia; Paya, Gema; Cardenal, Juan; Acuña, Enrique; Ferri, Maria [Department of Radiation Oncology, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria (Spain); Vazquez, Andres; Pacheco, Maite; Sanchez, Jesica [Department of Radiation Physics, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria (Spain)

2016-01-15

Objectives: We analyzed the long-term oncologic outcome for patients with prostate cancer and transurethral resection who were treated using low-dose-rate (LDR) prostate brachytherapy. Methods and Materials: From January 2001 to December 2005, 57 consecutive patients were treated with clinically localized prostate cancer. No patients received external beam radiation. All of them underwent LDR prostate brachytherapy. Biochemical failure was defined according to the 'Phoenix consensus'. Patients were stratified as low and intermediate risk based on The Memorial Sloan Kettering group definition. Results: The median follow-up time for these 57 patients was 104 months. The overall survival according to Kaplan-Meier estimates was 88% (±6%) at 5 years and 77% (±6%) at 12 years. The 5 and 10 years for failure in tumour-free survival (TFS) was 96% and respectively (±2%), whereas for biochemical control was 94% and respectively (±3%) at 5 and 10 years, 98% (±1%) of patients being free of local recurrence. A patient reported incontinence after treatment (1.7%). The chronic genitourinary complains grade I were 7% and grade II, 10%. At six months 94% of patients reported no change in bowel function. Conclusions: The excellent long-term results and low morbidity presented, as well as the many advantages of prostate brachytherapy over other treatments, demonstrates that brachytherapy is an effective treatment for patients with transurethral resection and clinical organ-confined prostate cancer. (author)

Long-term medical outcomes in survivors of extra-ocular retinoblastoma: the Memorial Sloan-Kettering Cancer Center (MSKCC) experience.

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Friedman, Danielle Novetsky; Sklar, Charles A; Oeffinger, Kevin C; Kernan, Nancy A; Khakoo, Yasmin; Marr, Brian P; Wolden, Suzanne L; Abramson, David H; Dunkel, Ira J

2013-04-01

Data on long-term outcomes of survivors of extra-ocular retinoblastoma are lacking. The authors sought to provide the first report characterizing long-term outcomes among survivors of extra-ocular retinoblastoma. Retrospective analysis of long-term medical outcomes in 19 survivors of extra-ocular retinoblastoma treated between 1992 and 2009. Severity of outcomes was graded using Common Terminology Criteria for Adverse Events. All patients received intensive multimodality therapy for their extra-ocular disease after management of their primary intra-ocular disease, including conventional chemotherapy (n = 19, 100%), radiotherapy (n = 15, 69%), and/or high-dose chemotherapy with autologous stem cell transplant (n = 17, 89%). The median follow-up was 7.8 years from diagnosis of extra-ocular retinoblastoma (range 2-17.8 years). The most common long-term non-visual outcomes were hearing loss (n = 15, 79%), short stature (n = 7, 37%), and secondary malignancies [SMN] (n = 6, 31%). Sixty-eight percent of survivors exhibited ≥2 non-visual long-term outcomes of any grade. Except short stature, which was not graded for severity, Grade 3-4 outcomes were limited to: ototoxicity (n = 8; n = 4 require hearing aids), SMNs (n = 6), and unequal limb length (n = 1). Five patients who developed SMNs carried a known RB1 mutation. SMNs developed at a median of 11.1 years after initial diagnosis; two patients died of their SMN. Long-term cardiac, pulmonary, hepatobiliary, or renal conditions were not identified in any survivors. Long-term outcomes are commonly seen in extra-ocular retinoblastoma survivors but the majority are mild-moderate in their severity. Longer comprehensive follow-up is needed to fully assess treatment-related outcomes but the information collected to date may affect management decisions for children with extra-ocular disease. Copyright © 2012 Wiley Periodicals, Inc.

Australia-wide comparison of intensity modulated radiation therapy prostate plans

International Nuclear Information System (INIS)

Skala, M.; Holloway, L.; Bailey, M.; Kneebone, A.

2005-01-01

The aim of this study was to investigate the ability of Australian centres to produce high-dose intensity modulated radiation therapy (IMRT) prostate plans, and to compare the planning parameters and resultant dose distributions. Five Australian radiation therapy departments were invited to participate. Each centre received an identical 5 mm-slice CT data set complete with contours of the prostate, seminal vesicles, rectum, bladder, femoral heads and body outline. The planning team was asked to produce the best plan possible, using published Memorial Sloan-Kettering Cancer Centre prescription and dose constraints. Three centres submitted plans for evaluation. All plans covered the planning target volume adequately; however, only one plan met all the critical organ dose constraints. Although the planning parameters, beam arrangements and planning systems were different for each centre, the resulting plans were similar. In Australia, IMRT for prostate cancer is in the early stages of implementation, with routine use limited to a few centres. Copyright (2005) Blackwell Science Pty Ltd

The Syed temporary interstitial iridium gynaecological implant: an inverse planning system

International Nuclear Information System (INIS)

Fung, Albert Y.C.

2002-01-01

Patients with advanced gynaecological cancer are often treated with a temporary interstitial implant using the Syed template and Ir-192 ribbons at the Memorial Sloan-Kettering Cancer Center. Urgency in planning is great. We created a computerized inverse planning system for the Syed temporary gynaecological implant, which optimized the ribbon strengths a few seconds after catheter digitization. Inverse planning was achieved with simulated annealing. We discovered that hand-drawn target volumes had drawbacks; hence instead of producing a grid of points based on target volume, the optimization points were generated directly from the catheter positions without requiring an explicit target volume. Since all seeds in the same ribbon had the same strength, the minimum doses were located at both ends of the implant. Optimization points generated at both ends ensured coverage of the whole implant. Inverse planning took only a few seconds, and generated plans that provide a good starting point for manual improvement. (author)

Clinical role of pathological downgrading after radical prostatectomy in patients with biopsy-proven Gleason score 3+4 prostate cancer

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Gondo, Tatsuo; Poon, Bing Ying; Matsumoto, Kazuhiro; Bernstein, Melanie; Sjoberg, Daniel D.; Eastham, James A.

2014-01-01

Objective To identify preoperative factors predicting Gleason score downgrading after radical prostatectomy in patients with biopsy Gleason score 3+4 prostate cancer. To determine if prediction of downgrading can identify potential candidates for active surveillance. Patients and Methods We identified 1317 patients with biopsy Gleason score 3+4 prostate cancer who underwent radical prostatectomy at Memorial Sloan-Kettering Cancer Center between 2005 and 2013. Several preoperative and biopsy characteristics were evaluated by forward selection regression, and selected predictors of downgrading were analyzed by multivariable logistic regression. Decision curve analysis was performed to evaluate the clinical utility of the multivariate model. Results Gleason score was downgraded after radical prostatectomy in 115 patients (9%). We developed a multivariable model using age, prostate specific antigen density, percent of positive cores with Gleason 4 cancer out of all cores taken, and maximum percent of cancer involvement within a positive core with Gleason 4 cancer. The area under the curve for this model was 0.75 after ten-fold cross validation. However, decision curve analysis revealed that the model was not clinically helpful in identifying patients who will downgrade at radical prostatectomy for the purpose of reassigning them to active surveillance. Conclusion While patients with pathology Gleason score 3+3 with tertiary Gleason pattern 4 or lower at radical prostatectomy in patients with biopsy Gleason score 3+4 prostate cancer may be potential candidates for active surveillance, decision curve analysis showed limited utility of our model to identify such men. Future study is needed to identify new predictors to help identify potential candidates for active surveillance among patients with biopsy-proven Gleason score 3+4 prostate cancer. PMID:24725760

Acute Skin Toxicity Following Stereotactic Body Radiation Therapy for Stage I Non-Small-Cell Lung Cancer: Who's at Risk?

International Nuclear Information System (INIS)

Hoppe, Bradford S.; Laser, Benjamin; Kowalski, Alex V.; Fontenla, Sandra C.; Pena-Greenberg, Elizabeth; Yorke, Ellen D.; Lovelock, D. Michael; Hunt, Margie A.; Rosenzweig, Kenneth E.

2008-01-01

Purpose: We examined the rate of acute skin toxicity within a prospectively managed database of patients treated for early-stage non-small-cell lung cancer (NSCLC) and investigated factors that might predict skin toxicity. Methods: From May 2006 through January 2008, 50 patients with Stage I NSCLC were treated at Memorial Sloan-Kettering Cancer Center with 60 Gy in three fractions or 44-48 Gy in four fractions. Patients were treated with multiple coplanar beams (3-7, median 4) with a 6 MV linac using intensity-modulated radiotherapy (IMRT) and dynamic multileaf collimation. Toxicity grading was performed and based on the National Cancer Institute Common Terminology Criteria for Adverse Effects. Factors associated with Grade 2 or higher acute skin reactions were calculated by Fisher's exact test. Results: After a minimum 3 months of follow-up, 19 patients (38%) developed Grade 1, 4 patients (8%) Grade 2, 2 patients (4%) Grade 3, and 1 patient Grade 4 acute skin toxicity. Factors associated with Grade 2 or higher acute skin toxicity included using only 3 beams (p = 0.0007), distance from the tumor to the posterior chest wall skin of less than 5 cm (p = 0.006), and a maximum skin dose of 50% or higher of the prescribed dose (p = 0.02). Conclusions: SBRT can be associated with significant skin toxicity. One must consider the skin dose when evaluating the treatment plan and consider the bolus effect of immobilization devices

Outcome of genetic evaluation of patients with kidney cancer referred for suspected hereditary cancer syndromes.

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Stratton, Kelly L; Alanee, Shaheen; Glogowski, Emily A; Schrader, Kasmintan A; Rau-Murthy, Rohini; Klein, Robert; Russo, Paul; Coleman, Jonathan; Offit, Kenneth

2016-05-01

To analyze patients with kidney cancer referred for evaluation at a high-volume genetics service at a comprehensive cancer center and identify factors associated with positive tests for hereditary cancer syndromes. A retrospective review of patients referred to the Clinical Genetics Service at Memorial Sloan-Kettering Cancer Center was performed, and patients with a personal history of kidney cancer were identified. Patient and disease characteristics were reviewed. In all, 4 variables including age at diagnosis of kidney tumor, presence of syndromic manifestations, family history of kidney cancer, and number of primary malignancies were evaluated for association with positive test results in 2 groups: patients tested for renal cell carcinoma syndromes and Lynch syndrome. Guidance for genetic testing strategy in patients with kidney cancer is provided. Between 1999 and 2012, 120 patients with a history of kidney cancer were evaluated by the Clinical Genetics Service. The mean age at kidney cancer diagnosis was 52 years (interquartile range: 42-63), with 57% being women. A family history of kidney cancer was reported by 39 patients (33%). Time between diagnosis of first cancer and genetic consultation was 5 years in the remaining 23%. Overall, 95 patients were tested for genetic abnormalities with 27 (28%) testing positive. Testing for renal cell carcinoma (RCC)-related syndromes was performed on 43 patients, with 13 testing positive (30%). Lynch syndrome testing was positive in 9 patients (32%) after 28 were tested. In RCC-associated syndromes, young age of diagnosis was associated with positive test results. Conversely, syndromic manifestations and increasing number of primary malignancies were associated with positive Lynch testing. The discovery of inherited kidney cancer syndromes has provided a unique opportunity to identify patients at increased risk for cancer. Factors associated with positive genetic testing are unique to different syndromes. These data

Radiation induced sarcomas of bone following therapeutic radiation

International Nuclear Information System (INIS)

Kim, J.H.; Chu, F.C.H.; Woodward, H.Q.; Huvos, A.

1983-01-01

Because of new therapeutic trends of multi-modality and the importance of late effects, we have updated our series of radiation induced bone sarcomas seen at Memorial Sloan-Kettering Cancer Center over the past four decades. A total of 37 cases of bone sarcoma arising from normal bone in the irradiated field was analyzed. The median for latent period from irradiation to diagnosis of bone sarcoma was 11 years with a minimum latent period of four years. The median radiation dose for the bone sarcoma was 6000 rad in 6 weeks with a minimum total radiation dose of 3000 rad in 3 weeks. We have found nine patients who developed bone sarcomas in the radiation field after successful treatment of Hodgkin's disease. Criteria for radiation induced bone sarcomas and the magnitude of the risk of bone sarcomas are briefly discussed

Support needs of Chinese immigrant cancer patients.

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Leng, Jennifer; Lee, Trevor; Li, Yanjun; Stern, Charles; Chen, Mei Hsuan; Winkel, Gary; Gany, Francesca

2014-01-01

To enable better psychosocial, informational, and practical support of Chinese patients with cancer, this study was conducted to identify the specific support needs of Chinese immigrant cancer patients. The Cancer Portal Project at Memorial Sloan-Kettering Cancer Center's Center for Immigrant Health and Cancer Disparities is a patient navigation program that assists underserved and minority cancer patients in obtaining social and economic assistance at ten New York City cancer clinics. This need assessment was conducted as part of the Portal Project. Sixty-four questions were added to the existing Portal Intake Form about the needs and preferences for Chinese-language support and survivorship services. Descriptive analysis was performed, as well as an exploratory principal component's factor analysis to determine if there were any patterns in the services and programs in which patients were interested. Ninety-six patients were approached for participation; 59 agreed to participate. Eighty-eight percent of participants were born in China. Ninety-seven percent preferred to speak Mandarin, Cantonese, or Fujianese in the healthcare setting. When asked about general interest in support programs, 53 % of the participants were "very interested," 27 % were "maybe interested," and 17 % were "not interested." Programs in which more participants were "very interested" included those that would provide information about obtaining financial assistance (79 %) and social assistance (74 %), information on treatment options (67 %), help in coping with the burden of illness on the family (65 %), and information about general healthcare (63 %). The factor analysis resulted in the identification of five factors: social/financial/treatment and care issues, nutrition and exercise/networking/general health care, coping with fear and stress, herbs and dietary supplements, and acupuncture and acupressure. In this study, 80 % of the participants expressed interest in programs tailored for

Randomized Controlled Trial of Family Therapy in Advanced Cancer Continued Into Bereavement.

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Kissane, David W; Zaider, Talia I; Li, Yuelin; Hichenberg, Shira; Schuler, Tammy; Lederberg, Marguerite; Lavelle, Lisa; Loeb, Rebecca; Del Gaudio, Francesca

2016-06-01

Systematic family-centered cancer care is needed. We conducted a randomized controlled trial of family therapy, delivered to families identified by screening to be at risk from dysfunctional relationships when one of their relatives has advanced cancer. Eligible patients with advanced cancer and their family members screened above the cut-off on the Family Relationships Index. After screening 1,488 patients or relatives at Memorial Sloan Kettering Cancer Center or three related community hospice programs, 620 patients (42%) were recruited, which represented 170 families. Families were stratified by three levels of family dysfunction (low communicating, low involvement, and high conflict) and randomly assigned to one of three arms: standard care or 6 or 10 sessions of a manualized family intervention. Primary outcomes were the Complicated Grief Inventory-Abbreviated (CGI) and Beck Depression Inventory-II (BDI-II). Generalized estimating equations allowed for clustered data in an intention-to-treat analysis. On the CGI, a significant treatment effect (Wald χ(2) = 6.88; df = 2; P = .032) and treatment by family-type interaction was found (Wald χ(2) = 20.64; df = 4; P families. Low-communicating families improved by 6 months of bereavement. In the standard care arm, 15.5% of the bereaved developed a prolonged grief disorder at 13 months of bereavement compared with 3.3% of those who received 10 sessions of intervention (Wald χ(2) = 8.31; df = 2; P =.048). No significant treatment effects were found on the BDI-II. Family-focused therapy delivered to high-risk families during palliative care and continued into bereavement reduced the severity of complicated grief and the development of prolonged grief disorder. © 2016 by American Society of Clinical Oncology.

Biobanking of human pancreas cancer tissue: impact of ex-vivo procurement times on RNA quality.

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Rudloff, Udo; Bhanot, Umesh; Gerald, William; Klimstra, David S; Jarnagin, William R; Brennan, Murray F; Allen, Peter J

2010-08-01

Tissue banking has become a major initiative at many oncology centers. The influence of warm ex-vivo ischemia times, storage times, and biobanking protocols on RNA integrity and subsequent microarray data is not well documented. A prospective institutional review board-approved protocol for the banking of abdominal neoplasms was initiated at Memorial Sloan-Kettering Cancer Center in 2001. Sixty-four representative pancreas cancer specimens snap-frozen at various ex-vivo procurement times (1 h) and banked during three time periods (2001-2004, 2004-2006, 2006-2008) were processed. RNA integrity was determined by microcapillary electrophoresis using the RNA integrity number (RIN) algorithm and by results of laser-capture microdissection (LCM). Overall, 42% of human pancreas cancer specimens banked under a dedicated protocol yielded RNA with a RIN of > or =7. Limited warm ex-vivo ischemia times did not negatively impact RNA quality (percentage of tissue with total RNA with RIN of > or =7 for 60 min, 42%), and long-term storage of banked pancreas cancer biospecimens did not negatively influence RNA quality (total RNA with RIN of > or =7 banked 2001-2004, 44%; 2004-2006, 38%; 2006-2008, 50%). RNA retrieved from pancreatic cancer samples with RIN of > or =7 subject to LCM yielded RNA suitable for further downstream applications. Fresh-frozen pancreas tissue banked within a standardized research protocol yields high-quality RNA in approximately 50% of specimens and can be used for enrichment by LCM. Quality of tissues of the biobank were not adversely impacted by limited variations of warm ischemia times or different storage periods. This study shows the challenges and investments required to initiate and maintain high-quality tissue repositories.

Final Report - DOE Center for Laser Imaging and Cancer Diagnostics

Energy Technology Data Exchange (ETDEWEB)

Alfano, Robert R.; Koutcher, Jason A.

2002-10-31

This Final Report summarizes the significant progress made by the researchers, students and staff of the Center for Laser Imaging and Cancer Diagnostics (CLICD) from January 1998 through May 2002. During this period, the Center supported several projects. Most projects were proposed initially, some were added subsequently as their relevance and importance to the DOE mission became evident. DOE support has been leveraged to obtain continuing funding for some projects. Leveraged funds come from various sources, including NIH, Army, NSF and the Air Force. The goal of the Center was to develop laser-based instruments for use in the detection and diagnosis of major diseases, with an emphasis on detection and diagnosis of various cancers. Each of the supported projects is a collaborative effort between physicists and laser scientists and the City College of New York and noted physicians, surgeons, pathologists, and biologists located at medical centers in the Metropolitan area. The participating institutions were: City College of New York Institute for Ultrafast Lasers and Spectroscopy, Hackensack University Medical Center, Lawrence Livermore National Laboratory, Memorial Sloan Kettering Cancer Center, and New York Eye and Ear Institute. Each of the projects funded by the Center is grouped into one of four research categories: a) Disease Detection, b) Non-Disease Applications, c) New Diagnostic Tools, and, d) Education, Training, Outreach and Dissemination. The progress achieved by the multidisciplinary teams was reported in 51 publications and 32 presentations at major national conferences. Also, one U.S. patent was obtained and six U.S. patent applications have been filed for innovations resulting from the projects sponsored by the Center.

An assessment of Prostate Cancer Research International: Active Surveillance (PRIAS) criteria for active surveillance of clinically low-risk prostate cancer patients

Science.gov (United States)

da Silva, Vitor; Cagiannos, Ilias; Lavallée, Luke T.; Mallick, Ranjeeta; Witiuk, Kelsey; Cnossen, Sonya; Eastham, James A.; Fergusson, Dean A.; Morash, Chris; Breau, Rodney H.

2017-01-01

Introduction Active surveillance is a strategy to delay or prevent treatment of indolent prostate cancer. The Prostate Cancer Research International: Active Surveillance (PRIAS) criteria were developed to select patients for prostate cancer active surveillance. The objective of this study was to compare pathological findings from PRIAS-eligible and PRIAS-ineligible clinically low-risk prostate cancer patients. Methods A D’Amico low-risk cohort of 1512 radical prostatectomy patients treated at The Ottawa Hospital or Memorial Sloan Kettering Cancer Centre between January 1995 and December 2007 was reviewed. Pathological outcomes (pT3 tumours, Gleason sum ≥7, lymph node metastases, or a composite) and clinical outcomes (prostate-specific antigen [PSA] recurrence, secondary cancer treatments, and death) were compared between PRIAS-eligible and PRIAS-ineligible cohorts. Results The PRIAS-eligible cohort (n=945) was less likely to have Gleason score ≥7 (odds ratio [OR] 0.61; 95% confidence interval [CI] 0.49–0.75), pT3 (OR 0.41; 95% CI 0.31–0.55), nodal metastases (OR 0.37; 95% CI 0.10–1.31), or any adverse feature (OR 0.56; 95% CI 0.45–0.69) compared to the PRIAS-ineligible cohort. The probability of any adverse pathology in the PRIAS-eligible cohort was 41% vs. 56% in the PRIAS-ineligible cohort. At median follow-up of 3.7 years, 72 (4.8%) patients had a PSA recurrence, 24 (1.6%) received pelvic radiation, and 13 (0.9%) received androgen deprivation. No difference was detected for recurrence-free and overall survival between groups (recurrence hazard ratio [HR] 0.71; 95% CI 0.46–1.09 and survival HR 0.72; 95% CI 0.36–1.47). Conclusions Low-risk prostate cancer patients who met PRIAS eligibility criteria are less likely to have higher-risk cancer compared to those who did not meet at least one of these criteria. PMID:28798822

15-Year biochemical relapse free survival in clinical Stage T1-T3 prostate cancer following combined external beam radiotherapy and brachytherapy; Seattle experience

International Nuclear Information System (INIS)

Sylvester, John E.; Grimm, Peter D.; Blasko, John C.; Millar, Jeremy; Orio, Peter F.; Skoglund, Scott; Galbreath, Robert W.; Merrick, Gregory

2007-01-01

Purpose: Long-term biochemical relapse-free survival (BRFS) rates in patients with clinical Stages T1-T3 prostate cancer continue to be scrutinized after treatment with external beam radiation therapy and brachytherapy. Methods and Materials: We report 15-year BRFS rates on 223 patients with clinically localized prostate cancer that were consecutively treated with I 125 or Pd 103 brachytherapy after 45-Gy neoadjuvant EBRT. Multivariate regression analysis was used to create a pretreatment clinical prognostic risk model using a modified American Society for Therapeutic Radiology and Oncology consensus definition (two consecutive serum prostate-specific antigen rises) as the outcome. Gleason scoring was performed by the pathologists at a community hospital. Time to biochemical failure was calculated and compared by using Kaplan-Meier plots. Results: Fifteen-year BRFS for the entire treatment group was 74%. BRFS using the Memorial Sloan-Kettering risk cohort analysis (95% confidence interval): low risk, 88%, intermediate risk 80%, and high risk 53%. Grouping by the risk classification described by D'Amico, the BRFS was: low risk 85.8%, intermediate risk 80.3%, and high risk 67.8% (p = 0.002). Conclusions: I 125 or Pd 103 brachytherapy combined with supplemental EBRT results in excellent 15-year biochemical control. Different risk group classification schemes lead to different BRFS results in the high-risk group cohorts

Radiotherapy of prostate cancer

International Nuclear Information System (INIS)

Krause, S.; Herfarth, K.

2011-01-01

With the development of modern radiation techniques, such as intensity-modulated radiotherapy (IMRT), a dose escalation in the definitive radiotherapy of prostate cancer and a consecutive improvement in biochemical recurrence-free survival (BFS) could be achieved. Among others, investigators at the Memorial Sloan-Kettering Cancer Center (MSKCC) saw 5-year BFS rates of up to 98%. A further gain in effectiveness and safety is expected of hypofractionation schedules, as suggested by data published by Kupelian et al., who saw a low 5-year rate of grade ≥2 rectal side-effects of 4.5%. However, randomized studies are just beginning to mature. Patients with intermediate or high-risk tumors should receive neoadjuvant (NHT) and adjuvant (AHT) androgen deprivation. Bolla et al. could show an increase in 5-year overall survival from 62-78%. The inclusion of the whole pelvis in the treatment field (WPRT) is still controversial. The RTOG 94-13 study showed a significant advantage in disease-free survival after 60 months but long-term data did not yield significant differences between WPRT and irradiation of the prostate alone. The German Society of Urology strongly recommends adjuvant radiotherapy of the prostate bed for pT3 N0 tumors with positive margins. In a pT3 N0 R0 or pT2 N0 R+ situation, adjuvant radiotherapy should at least be considered. So far, no randomized data on NHT and AHT have been published, so androgen deprivation remains an individual decision in the postoperative setting. In a retrospective analysis Spiotto et al. reported a positive effect for adjuvant WPRT and biochemical control. This article summarizes the essential publications on definitive and adjuvant radiotherapy and discusses the additional use of androgen deprivation and WPRT. (orig.) [de

Clinical role of pathological downgrading after radical prostatectomy in patients with biopsy confirmed Gleason score 3 + 4 prostate cancer.

Science.gov (United States)

Gondo, Tatsuo; Poon, Bing Ying; Matsumoto, Kazuhiro; Bernstein, Melanie; Sjoberg, Daniel D; Eastham, James A

2015-01-01

To identify preoperative factors predicting Gleason score downgrading after radical prostatectomy (RP) in patients with biopsy Gleason score 3+4 prostate cancer and to determine if prediction of downgrading can identify potential candidates for active surveillance (AS). We identified 1317 patients with biopsy Gleason score 3+4 prostate cancers who underwent RP at the Memorial Sloan-Kettering Cancer Center between 2005 and 2013. Several preoperative and biopsy characteristics were evaluated by forward selection regression, and selected predictors of downgrading were analysed by multivariable logistic regression. Decision curve analysis was used to evaluate the clinical utility of the multivariate model. Gleason score was downgraded after RP in 115 patients (9%). We developed a multivariable model using age, prostate-specific antigen density, percentage of positive cores with Gleason pattern 4 cancer out of all cores taken, and maximum percentage of cancer involvement within a positive core with Gleason pattern 4 cancer. The area under the curve for this model was 0.75 after 10-fold cross validation. However, decision curve analysis revealed that the model was not clinically helpful in identifying patients who will downgrade at RP for the purpose of reassigning them to AS. While patients with pathological Gleason score 3 + 3 with tertiary Gleason pattern ≤4 at RP in patients with biopsy Gleason score 3 + 4 prostate cancer may be potential candidates for AS, decision curve analysis showed limited utility of our model to identify such men. Future study is needed to identify new predictors to help identify potential candidates for AS among patients with biopsy confirmed Gleason score 3 + 4 prostate cancer. © 2014 The Authors. BJU International © 2014 BJU International.

Management of cutaneous T cell lymphoma: new and emerging targets and treatment options

Directory of Open Access Journals (Sweden)

Li JY

2012-03-01

Full Text Available Janet Y Li1, Steven Horwitz2, Alison Moskowitz2, Patricia L Myskowski3, Melissa Pulitzer4, Christiane Querfeld31College of Physicians and Surgeons, Columbia University, 2Department of Medicine, Lymphoma Service, 3Department of Medicine, Dermatology Service, 4Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USAAbstract: Cutaneous T cell lymphomas (CTCL clinically and biologically represent a heterogeneous group of non-Hodgkin lymphomas, with mycosis fungoides and Sézary syndrome being the most common subtypes. Over the last decade, new immunological and molecular pathways have been identified that not only influence CTCL phenotype and growth, but also provide targets for therapies and prognostication. This review will focus on recent advances in the development of therapeutic agents, including bortezomib, the histone deacetylase inhibitors (vorinostat and romidepsin, and pralatrexate in CTCL.Keywords: novel targets, histone deacetylase inhibitors, pralatrexate, bortezomib, cutaneous T cell lymphoma

Radiation therapy for Ewing's sarcoma: Results from Memorial Sloan-Kettering in the modern era

International Nuclear Information System (INIS)

La, Trang H.; Meyers, Paul A.; Wexler, Leonard H.; Alektiar, Kaled M.; Healey, John H.; Laquaglia, Michael P.; Boland, Patrick J.; Wolden, Suzanne L.

2006-01-01

Purpose: To evaluate the outcomes of patients with Ewing's sarcoma family of tumors (ESFT) treated with modern radiotherapy techniques with MRI along with optimal chemotherapy. Methods and Materials: The records of all 60 patients with ESFT who received radiation to the primary site between 1990 and 2004 were reviewed. All patients received chemotherapy, including vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide. Radiation was used as the sole modality for local control in 31 patients and was given either before (n = 3) or after surgical resection (n = 26) in the remainder. All patients had MRI and CT scan-based treatment planning, and 43% received intensity-modulated radiation therapy. Radiation doses ranged from 30 Gy to 60 Gy (median, 51 Gy), and 35% received hyperfractionated radiotherapy. Results: Median age was 16 years (range, 2-40 years). Because of selection bias for radiotherapy, the majority of primary tumors were centrally located (72%): spine (n = 18), pelvis (n = 15), extremities (n 12), chest wall (n = 5), head and neck (n = 5), and other (n = 5). Thirty-eight percent of patients presented with metastatic disease, and 52% of primary tumors were ≥8 cm. Actuarial 3-year local control was 77%. The presence of metastases at diagnosis was an adverse prognostic factor for local control (84% vs. 61%, p = 0.036). No other predictive factors for local failure were identified. In patients without metastatic disease, 3-year disease-free and overall survival rates were 70% and 86%, respectively, whereas in patients with metastases they were both 21%. Follow-up of surviving patients was 6-178 months (median, 41 months). Conclusion: In this unfavorable cohort of ESFT patients, radiation therapy was an effective modality for local control, especially for patients without metastases. The presence of metastases at diagnosis is a predictive factor not only for death but also for local failure

Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression.

Directory of Open Access Journals (Sweden)

Nitin Patel

Full Text Available Prostate cancer (PCa is the second-leading cause of cancer-related mortality, after lung cancer, in men from developed countries. In its early stages, primary tumor growth is dependent on androgens, thus generally can be controlled by androgen deprivation therapy (ADT. Eventually however, the disease progresses to castration-resistant prostate cancer (CRPC, a lethal form in need of more effective treatments. G-protein coupled receptors (GPCRs comprise a large clan of cell surface proteins that have been implicated as therapeutic targets in PCa growth and progression. The findings reported here provide intriguing evidence of a role for the newly characterized glutamate family member GPR158 in PCa growth and progression. We found that GPR158 promotes PCa cell proliferation independent of androgen receptor (AR functionality and that this requires its localization in the nucleus of the cell. This suggests that GPR158 acts by mechanisms different from other GPCRs. GPR158 expression is stimulated by androgens and GPR158 stimulates AR expression, implying a potential to sensitize tumors to low androgen conditions during ADT via a positive feedback loop. Further, we found GPR158 expression correlates with a neuroendocrine (NE differentiation phenotype and promotes anchorage-independent colony formation implying a role for GPR158 in therapeutic progression and tumor formation. GPR158 expression was increased at the invading front of prostate tumors that formed in the genetically defined conditional Pten knockout mouse model, and co-localized with elevated AR expression in the cell nucleus. Kaplan-Meier analysis on a dataset from the Memorial Sloan Kettering cancer genome portal showed that increased GPR158 expression in tumors is associated with lower disease-free survival. Our findings strongly suggest that pharmaceuticals targeting GPR158 activities could represent a novel and innovative approach to the prevention and management of CRPC.

Treatment of nasal cavity and paranasal sinus cancer with modern radiotherapy techniques in the postoperative setting-the MSKCC experience

International Nuclear Information System (INIS)

Hoppe, Bradford S.; Stegman, Lauren D.; Zelefsky, Michael J.; Rosenzweig, Kenneth E.; Wolden, Suzanne L.; Patel, Snehal G.; Shah, Jatin P.; Kraus, Dennis H.; Lee, Nancy Y.

2007-01-01

Purpose: To perform a retrospective analysis of patients with paranasal sinus (PNS) cancer treated with postoperative radiotherapy (RT) at Memorial Sloan-Kettering Cancer Center. Methods and Materials: Between January 1987 and July 2005, 85 patients with PNS and nasal cavity cancer underwent postoperative RT. Most patients had squamous cell carcinoma (49%; n = 42), T4 tumors (52%; n = 36), and the maxillary sinus (53%; n = 45) as the primary disease site. The median radiation dose was 63 Gy. Of the 85 patients, 76 underwent CT simulation and 53 were treated with either three-dimensional conformal RT (27%; n = 23) or intensity-modulated RT (35%; n = 30). Acute and late toxicities were scored according to the Radiation Therapy Oncology Group radiation morbidity scoring criteria. Results: With a median follow-up for surviving patients of 60 months, the 5-year estimates of local progression-free, regional progression-free, distant metastasis-free, disease-free, and overall survival rates were 62%, 87%, 82%, 55%, and 67%, respectively. On multivariate analysis, squamous cell histology and cribriform plate involvement predicted for an increased likelihood of local recurrence, and squamous cell histologic features predicted for worse overall survival. None of the patients who underwent CT simulation and were treated with modern techniques developed a Grade 3-4 late complication of the eye. Conclusion: Complete surgical resection followed by adjuvant RT is an effective and safe approach in the treatment of PNS cancer. Emerging tools, such as three-dimensional conformal treatment and, in particular, intensity-modulated RT for PNS tumors, may minimize the occurrence of late complications associated with conventional RT techniques. Local recurrence remains a significant problem

Design of multifunctional magnetic iron oxide nanoparticles/mitoxantrone-loaded liposomes for both magnetic resonance imaging and targeted cancer therapy.

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He, Yingna; Zhang, Linhua; Zhu, Dunwan; Song, Cunxian

2014-01-01

Tumor-targeting multifunctional liposomes simultaneously loaded with magnetic iron oxide nanoparticles (MIONs) as a magnetic resonance imaging (MRI) contrast agent and anticancer drug, mitoxantrone (Mit), were developed for targeted cancer therapy and ultrasensitive MRI. The gonadorelin-functionalized MION/Mit-loaded liposome (Mit-GML) showed significantly increased uptake in luteinizing hormone-releasing hormone (LHRH) receptor overexpressing MCF-7 (Michigan Cancer Foundation-7) breast cancer cells over a gonadorelin-free MION/Mit-loaded liposome (Mit-ML) control, as well as in an LHRH receptor low-expressing Sloan-Kettering HER2 3+ Ovarian Cancer (SK-OV-3) cell control, thereby leading to high cytotoxicity against the MCF-7 human breast tumor cell line. The Mit-GML formulation was more effective and less toxic than equimolar doses of free Mit or Mit-ML in the treatment of LHRH receptors overexpressing MCF-7 breast cancer xenografts in mice. Furthermore, the Mit-GML demonstrated much higher T2 enhancement than did Mit-ML controls in vivo. Collectively, the study indicates that the integrated diagnostic and therapeutic design of Mit-GML nanomedicine potentially allows for the image-guided, target-specific treatment of cancer.

Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease.

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Yaeger, Rona; Shah, Manish A; Miller, Vincent A; Kelsen, Judith R; Wang, Kai; Heins, Zachary J; Ross, Jeffrey S; He, Yuting; Sanford, Eric; Yantiss, Rhonda K; Balasubramanian, Sohail; Stephens, Philip J; Schultz, Nikolaus; Oren, Moshe; Tang, Laura; Kelsen, David

2016-08-01

Patients with inflammatory bowel diseases, such as Crohn's disease (CD) and ulcerative colitis (UC), are at increased risk for small bowel or colorectal cancers (colitis-associated cancers [CACs]). We compared the spectrum of genomic alterations in CACs with those of sporadic colorectal cancers (CRCs) and investigated differences between CACs from patients with CD vs UC. We studied tumor tissues from patients with CACs treated at Memorial Sloan Kettering Cancer Center or Weill Cornell Medical College from 2003 through 2015. We performed hybrid capture-based next-generation sequencing analysis of >300 cancer-related genes to comprehensively characterize genomic alterations. We performed genomic analyses of 47 CACs (from 29 patients with UC and 18 with CD; 43 primary tumors and 4 metastases). Primary tumors developed in the ileum (n = 2), right colon (n = 18), left colon (n = 6), and rectosigmoid or rectum (n = 21). We found genomic alterations in TP53, IDH1, and MYC to be significantly more frequent, and mutations in APC to be significantly less frequent, than those reported in sporadic CRCs by The Cancer Genome Atlas or Foundation Medicine. We identified genomic alterations that might be targeted by a therapeutic agent in 17 of 47 (36%) CACs. These included the mutation encoding IDH1 R132; amplification of FGFR1, FGFR2, and ERBB2; and mutations encoding BRAF V600E and an EML4-ALK fusion protein. Alterations in IDH1 and APC were significantly more common in CACs from patients with CD than UC. In an analysis of CACs from 47 patients, we found significant differences in the spectrum of genomic alterations in CACs compared with sporadic CRCs. We observed a high frequency of IDH1 R132 mutations in patients with CD but not UC, as well as a high frequency of MYC amplification in CACs. Many genetic alterations observed in CACs could serve as therapeutic targets. Copyright © 2016 AGA Institute. Published by Elsevier Inc. All rights reserved.

Development of a Nomogram Model Predicting Current Bone Scan Positivity in Patients Treated with Androgen-Deprivation Therapy for Prostate Cancer

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Gotto, Geoffrey T.; Yu, Changhong; Bernstein, Melanie; Eastham, James A.; Kattan, Michael W.

2014-01-01

Purpose: To develop a nomogram predictive of current bone scan positivity in patients receiving androgen-deprivation therapy (ADT) for advanced prostate cancer; to augment clinical judgment and highlight patients in need of additional imaging investigations. Materials and methods: A retrospective chart review of bone scan records (conventional 99mTc-scintigraphy) of 1,293 patients who received ADT at the Memorial Sloan-Kettering Cancer Center from 2000 to 2011. Multivariable logistic regression analysis was used to identify variables suitable for inclusion in the nomogram. The probability of current bone scan positivity was determined using these variables and the predictive accuracy of the nomogram was quantified by concordance index. Results: In total, 2,681 bone scan records were analyzed and 636 patients had a positive result. Overall, the median pre-scan prostate-specific antigen (PSA) level was 2.4 ng/ml; median PSA doubling time (PSADT) was 5.8 months. At the time of a positive scan, median PSA level was 8.2 ng/ml; 53% of patients had PSA <10 ng/ml; median PSADT was 4.0 months. Five variables were included in the nomogram: number of previous negative bone scans after initiating ADT, PSA level, Gleason grade sum, and history of radical prostatectomy and radiotherapy. A concordance index value of 0.721 was calculated for the nomogram. This was a retrospective study based on limited data in patients treated in a large cancer center who underwent conventional 99mTc bone scans, which themselves have inherent limitations. Conclusion: This is the first nomogram to predict current bone scan positivity in ADT-treated prostate cancer patients, providing high predictive accuracy. PMID:25386410

Development of a nomogram model predicting current bone scan positivity in patients treated with androgen-deprivation therapy for prostate cancer

Directory of Open Access Journals (Sweden)

Michael eKattan

2014-10-01

Full Text Available Purpose: To develop a nomogram predictive of current bone scan positivity in patients receiving androgen-deprivation therapy (ADT for advanced prostate cancer; to augment clinical judgment and highlight patients in need of additional imaging investigations.Materials and Methods: A retrospective chart review of bone scan records (conventional 99mTc-scintigraphy of 1,293 patients who received ADT at the Memorial Sloan-Kettering Cancer Center from 2000 to 2011. Multivariable logistic regression analysis was used to identify variables suitable for inclusion in the nomogram. The probability of current bone scan positivity was determined using these variables and the predictive accuracy of the nomogram was quantified by concordance index.Results: In total, 2,681 bone scan records were analyzed and 636 patients had a positive result. Overall, the median pre-scan prostate-specific antigen (PSA level was 2.4 ng/ml; median PSA doubling time (PSADT was 5.8 months. At the time of a positive scan, median PSA level was 8.2 ng/ml; 53% of patients had PSA <10 ng/ml; median PSADT was 4.0 months. Five variables were included in the nomogram: number of previous negative bone scans after initiating ADT, PSA level, Gleason grade sum, and history of radical prostatectomy and radiotherapy. A concordance index value of 0.721 was calculated for the nomogram. This was a retrospective study based on limited data in patients treated in a large cancer centre who underwent conventional 99mTc bone scans, which themselves have inherent limitations. Conclusions: This is the first nomogram to predict current bone scan positivity in ADT-treated prostate cancer patients, providing high predictive accuracy.

Tumor Genomic Profiling in Breast Cancer Patients Using Targeted Massively Parallel Sequencing

Science.gov (United States)

2016-03-01

2015 “Cancer Care as a Model for Precision Medicine” MIT Collaborative Series Massachusetts Institute of Technology Invited Talk 2016 “Cancer...Precision Medicine” MIT -CHIEF Series Massachusetts Institute of Technology Invited Talk National 2013 “CanSeq: The Use of Whole Exome Sequencing To...Pennsylvania Philadelphia, PA Invited Talk 2014 “Clinical Genomics and Precision Cancer Medicine” Center for Molecular Oncology Memorial Sloan

Outcomes of asymptomatic anastomotic leaks found on routine postoperative water-soluble enema following anterior resection for cancer.

Science.gov (United States)

Killeen, S; Souroullas, P; Ho Tin, H; Hunter, I A; O'Grady, H; Gunn, J; Hartley, J E

2013-11-01

The incidence and consequence of an anastomotic leak associated with low anterior resection for cancer mandates covering stoma in most cases. A water-soluble enema is often performed to assess anastomotic integrity prior to stoma reversal. The functional outcome following reversal in patients with occult radiologically detected leaks is poorly defined. The goal of the present study was to determine the functional outcome in patients with a radiologically detected anastomotic leak who subsequently underwent stoma reversal. This case control study used patients with and without radiologically detected occult anastomotic leak having undergone reversal of covering stomata. The study group was matched with controls for age, gender, procedure, tumor stage, and adjuvant/neoadjuvant therapy. Validated fecal incontinence quality of life (FIQL), Cleveland Clinic Fecal Incontinence Score (CCFIS), and the Memorial Sloan-Kettering Cancer Center (MSKCC) Bowel Function Index (BFI) were used. Patient satisfaction, medication use, and ancillary procedures prior to closure were also recorded. Thirteen patients with radiologically detected occult anastomotic leaks and 13 matched controls were identified from a prospectively maintained database. The FIQL, CCFIS, and MSKCC BFI scores were significantly reduced in those with occult leaks. The mean number of radiological and surgical interventions was significantly greater in the patients with occult leaks. Antidiarrheal and bulking agent use, as well as patient satisfaction, were the same for both groups. Only one patient in the occult leak group would not undergo stoma reversal again. Reversal of a defunctioning ileostomy in the presence of an occult radiological leak can be associated with poorer functional outcomes, but patient satisfaction is undiminished.

SU-E-J-115: Using Markov Chain Modeling to Elucidate Patterns in Breast Cancer Metastasis Over Time and Space

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Comen, E; Mason, J; Kuhn, P [The Scripps Research Institute, La Jolla, CA (United States); Nieva, J [Billings Clinic, Billings, Montana (United States); Newton, P [University of Southern California, Los Angeles, CA (United States); Norton, L; Venkatappa, N; Jochelson, M [Memorial Sloan-Kettering Cancer Center, NY, NY (United States)

2014-06-01

Purpose: Traditionally, breast cancer metastasis is described as a process wherein cancer cells spread from the breast to multiple organ systems via hematogenous and lymphatic routes. Mapping organ specific patterns of cancer spread over time is essential to understanding metastatic progression. In order to better predict sites of metastases, here we demonstrate modeling of the patterned migration of metastasis. Methods: We reviewed the clinical history of 453 breast cancer patients from Memorial Sloan Kettering Cancer Center who were non-metastatic at diagnosis but developed metastasis over time. We used the variables of organ site of metastases as well as time to create a Markov chain model of metastasis. We illustrate the probabilities of metastasis occurring at a given anatomic site together with the probability of spread to additional sites. Results: Based on the clinical histories of 453 breast cancer patients who developed metastasis, we have learned (i) how to create the Markov transition matrix governing the probabilities of cancer progression from site to site; (ii) how to create a systemic network diagram governing disease progression modeled as a random walk on a directed graph; (iii) how to classify metastatic sites as ‘sponges’ that tend to only receive cancer cells or ‘spreaders’ that receive and release them; (iv) how to model the time-scales of disease progression as a Weibull probability distribution function; (v) how to perform Monte Carlo simulations of disease progression; and (vi) how to interpret disease progression as an entropy-increasing stochastic process. Conclusion: Based on our modeling, metastatic spread may follow predictable pathways. Mapping metastasis not simply by organ site, but by function as either a ‘spreader’ or ‘sponge’ fundamentally reframes our understanding of metastatic processes. This model serves as a novel platform from which we may integrate the evolving genomic landscape that drives cancer

SU-E-J-115: Using Markov Chain Modeling to Elucidate Patterns in Breast Cancer Metastasis Over Time and Space

International Nuclear Information System (INIS)

Comen, E; Mason, J; Kuhn, P; Nieva, J; Newton, P; Norton, L; Venkatappa, N; Jochelson, M

2014-01-01

Purpose: Traditionally, breast cancer metastasis is described as a process wherein cancer cells spread from the breast to multiple organ systems via hematogenous and lymphatic routes. Mapping organ specific patterns of cancer spread over time is essential to understanding metastatic progression. In order to better predict sites of metastases, here we demonstrate modeling of the patterned migration of metastasis. Methods: We reviewed the clinical history of 453 breast cancer patients from Memorial Sloan Kettering Cancer Center who were non-metastatic at diagnosis but developed metastasis over time. We used the variables of organ site of metastases as well as time to create a Markov chain model of metastasis. We illustrate the probabilities of metastasis occurring at a given anatomic site together with the probability of spread to additional sites. Results: Based on the clinical histories of 453 breast cancer patients who developed metastasis, we have learned (i) how to create the Markov transition matrix governing the probabilities of cancer progression from site to site; (ii) how to create a systemic network diagram governing disease progression modeled as a random walk on a directed graph; (iii) how to classify metastatic sites as ‘sponges’ that tend to only receive cancer cells or ‘spreaders’ that receive and release them; (iv) how to model the time-scales of disease progression as a Weibull probability distribution function; (v) how to perform Monte Carlo simulations of disease progression; and (vi) how to interpret disease progression as an entropy-increasing stochastic process. Conclusion: Based on our modeling, metastatic spread may follow predictable pathways. Mapping metastasis not simply by organ site, but by function as either a ‘spreader’ or ‘sponge’ fundamentally reframes our understanding of metastatic processes. This model serves as a novel platform from which we may integrate the evolving genomic landscape that drives cancer

Patterns of Utilization of Adjuvant Radiotherapy and Outcomes in Black Women After Breast Conservation at a Large Multidisciplinary Cancer Center

International Nuclear Information System (INIS)

Edwards-Bennett, Sophia M.; Jacks, Lindsay M.; McCormick, Beryl; Zhang, Zhigang; Azu, Michelle; Ho, Alice; Powell, Simon; Brown, Carol

2011-01-01

Purpose: Population-based studies have reported that as many of 35% of black women do not undergo radiotherapy (RT) after breast conservation surgery (BCS). The objective of the present study was to determine whether this trend persisted at a large multidisciplinary cancer center, and to identify the factors that predict for noncompliance with RT and determine the outcomes for this subset of patients. Methods and Materials: Between January 2002 and December 2007, 83 black women underwent BCS at Memorial Sloan-Kettering Cancer Center and were therefore eligible for the present study. Of the 83 women, 38 (46%) had Stage I, 38 (46%) Stage II, and 7 (8%) Stage III disease. Of the study cohort, 31 (37%) had triple hormone receptor-negative tumors. RT was recommended for 81 (98%) of the 83 patients (median dose, 60 Gy). Results: Of the 81 women, 12 (15%) did not receive the recommended adjuvant breast RT. Nonreceipt of chemotherapy (p = .003) and older age (p = .009) were associated with nonreceipt of RT. With a median follow-up of 70 months, the 3-year local control, locoregional control, recurrence-free survival, disease-free survival, and overall survival rate was 99% (actuarial 5-year rate, 97%), 96% (actuarial 5-year rate, 93%), 95% (actuarial 5-year rate, 92%), 92% (actuarial 5-year rate, 89%), and 95% (actuarial 5-year rate, 91%), respectively. Conclusion: We found a greater rate of utilization adjuvant breast RT (85%) among black women after BCS than has been reported in recent studies, indicating that excellent outcomes are attainable for black women after BCS when care is administered in a multidisciplinary cancer center.

Use of positron emission tomography scan response to guide treatment change for locally advanced gastric cancer: the Memorial Sloan Kettering Cancer Center experience.

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Won, Elizabeth; Shah, Manish A; Schöder, Heiko; Strong, Vivian E; Coit, Daniel G; Brennan, Murray F; Kelsen, David P; Janjigian, Yelena Y; Tang, Laura H; Capanu, Marinela; Rizk, Nabil P; Allen, Peter J; Bains, Manjit S; Ilson, David H

2016-08-01

Early metabolic response on 18-fluorodeoxyglucose-positron emission tomography (FDG-PET) during neoadjuvant chemotherapy is PET non-responders have poor outcomes whether continuing chemotherapy or proceeding directly to surgery. Use of PET may identify early treatment failure, sparing patients from inactive therapy and allowing for crossover to alternative therapies. We examined the effectiveness of PET directed switching to salvage chemotherapy in the PET non-responders. Patients with locally advanced resectable FDG-avid gastric or gastroesophageal junction (GEJ) adenocarcinoma received bevacizumab 15 mg/kg, epirubicin 50 mg/m(2), cisplatin 60 mg/m(2) day 1, and capecitabine 625 mg/m(2) bid (ECX) every 21 days. PET scan was obtained at baseline and after cycle 1. PET responders, (i.e., ≥35% reduction in FDG uptake at the primary tumor) continued ECX + bev. Non-responders switched to docetaxel 30 mg/m(2), irinotecan 50 mg/mg(2) day 1 and 8 plus bevacizumab every 21 days for 2 cycles. Patients then underwent surgery. The primary objective was to improve the 2-year disease free survival (DFS) from 30% (historical control) to 53% in the non-responders. Twenty evaluable patients enrolled before the study closed for poor accrual. Eleven were PET responders and the 9 non-responders switched to the salvage regimen. With a median follow-up of 38.2 months, the 2-year DFS was 55% [95% confidence interval (CI), 30-85%] in responders compared with 56% in the non-responder group (95% CI, 20-80%, P=0.93). The results suggest that changing chemotherapy regimens in PET non-responding patients may improve outcomes. Results from this pilot trial are hypothesis generating and suggest that PET directed neoadjuvant therapy merits evaluation in a larger trial.

The Public Health Impact of Herbs and Nutritional Supplements

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Cassileth, Barrie R.; Heitzer, Marjet; Wesa, Kathleen

2009-01-01

Dietary supplement use has increased exponentially in recent years despite the lack of regulatory oversight and in the face of growing safety concerns. This paper provides an overview of the public health implications and safety concerns associated with dietary supplement use, especially by cancer patients. Botanical research is actively pursued at the Memorial Sloan-Kettering Cancer Center (MSKCC) Integrative Medicine department. Work of the MSKCC Center for the Study of Botanical Immunomodulators is described, and guidelines for cancer patients’ use of dietary supplements outlined. Herbs and other botanicals are complex, physiologically active agents, but little is known about most of the popular, widely available dietary supplements. Herb-drug interactions, a major concern, are exacerbated in the cancer setting. Biologically active agents may interfere with chemotherapy and other prescription medications. They may exert anti-coagulant activity at rather inconvenient times such as during surgery, and create other serious problems. Research on the bioavailability, effective dosage, safety and benefits of these complex agents is sorely needed. Oncology professionals and other healthcare providers should educate themselves and their patients about these issues. Probably the largest, continuously-updated free information resource is MSKCC’s AboutHerbs website (www.mskcc.org/AboutHerbs). PMID:19890479

Symptom Severity and Quality of Life Among Long-term Colorectal Cancer Survivors Compared With Matched Control Subjects: A Population-Based Study.

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Hart, Tae L; Charles, Susan T; Gunaratne, Mekhala; Baxter, Nancy N; Cotterchio, Michelle; Cohen, Zane; Gallinger, Steven

2018-03-01

Data are lacking regarding physical functioning, psychological well-being, and quality of life among colorectal cancer survivors >10 years postdiagnosis. The purpose of this study was to examine self-reported physical functioning, quality of life, and psychological well-being in long-term colorectal cancer survivors compared with age- and sex-matched unaffected control subjects. Participants completed a cross-sectional survey. The colorectal cancer survivors and unaffected control subjects were recruited from the Ontario Familial Colorectal Cancer Registry. A population-based sample of colorectal cancer survivors (N = 296) and their age- and sex-matched unaffected control subjects (N = 255) were included. Survivors were, on average, 15 years postdiagnosis. Quality of life was measured with the Functional Assessment of Cancer Therapy-General scale, bowel dysfunction with the Memorial Sloan-Kettering Cancer Center scale, urinary dysfunction with the International Consultation on Incontinence Questionnaire-Short Form, fatigue with the Functional Assessment of Chronic Illness Therapy-Fatigue scale, and depression with the Center for Epidemiologic Studies-Depression scale. In linear mixed-model analyses adjusting for income, education, race, and comorbid medical conditions, survivors reported good emotional, functional, physical, and overall quality of life, comparable to control subjects. Fatigue and urinary functioning did not differ significantly between survivors and control subjects. Survivors reported significantly higher social quality of life and lower depression compared with unaffected control subjects. The only area where survivors reported significantly worse deficits was in bowel dysfunction, but the magnitude of differences was relatively small. Generalizability is limited by moderately low participation rates. Findings are likely biased toward healthy participants. No baseline assessment was available to examine change in outcomes over time. Long

Control of norovirus outbreak on a pediatric oncology unit.

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Sheahan, Anna; Copeland, Gretchen; Richardson, Lauren; McKay, Shelley; Chou, Alexander; Babady, N Esther; Tang, Yi-Wei; Boulad, Farid; Eagan, Janet; Sepkowitz, Kent; Kamboj, Mini

2015-10-01

Patients undergoing treatment for cancer with chemotherapy and hematopoietic stem cell recipients are at risk for severe morbidity caused by norovirus (NV). We describe a NV outbreak on the Memorial Sloan Kettering Cancer Center's pediatric oncology unit. Stool testing for diagnosis of NV was performed by real-time polymerase chain reaction (PCR). Twelve NV cases occurred; 7 were hospital acquired. Twenty-five health care workers reported NV compatible illness. Patient-to-patient transmission occurred once. The practices of the Centers for Disease Control and Prevention were supplemented with electronic surveillance, surrogate screening for NV, and heightened cleaning. Two additional cases occurred after implementation of interventions. Long-term shedding was detected in 2 patients. We describe interventions for controlling NV on a pediatric oncology unit. High-risk chronic shedders pose ongoing transmission risks. PCR is a valuable diagnostic tool but may be overly sensitive. Surrogate markers to assess NV burden in stool and studies on NV screening are needed to develop guidelines for high-risk chronic shedders. Copyright © 2015 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

Incidence of chemotherapy-induced amenorrhea in premenopausal women treated with adjuvant FOLFOX for colorectal cancer.

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Cercek, Andrea; Siegel, Cara L; Capanu, Marinela; Reidy-Lagunes, Diane; Saltz, Leonard B

2013-09-01

Studies indicate that the incidence of young women diagnosed with colorectal cancer is rising, thus there is an increasing number of female colorectal cancer survivors of premenopausal and child-bearing age. Adjuvant FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin) chemotherapy is the most widely used standard treatment for stage III and high-risk stage II colon cancer. We evaluated the incidence of FOLFOX-induced amenorrhea in women age 50 and younger treated with adjuvant therapy for colorectal cancer. A search of pharmacy records identified 119 women age 50 or younger who received adjuvant FOLFOX chemotherapy at Memorial Sloan-Kettering for stage II or III colorectal cancer from January 2002 and January 2011. Eligible patients were mailed an anonymous questionnaire. The returned surveys were reviewed and the results tallied. Seventy-three patients returned the questionnaire. Twenty-four patients were excluded from analysis: 19 were treated with pelvic radiotherapy, 2 patients had undergone bilateral oophorectomy, 2 had a hysterectomy, and 1 stopped menstruating before diagnosis. Forty-nine patient responses were analyzed. In total, 41% (n = 20) experienced amenorrhea during chemotherapy. Sixteen percent had persistent amenorrhea 1 year after completion of chemotherapy. The incidence of amenorrhea during chemotherapy trended higher in patients aged older than 40 compared with patients aged 40 and younger (59% vs. 31% [P = .075]). There was no statistically significant difference in persistent amenorrhea between the 2 age groups (24% vs. 13%; P = .42). In this retrospective series, there appears to be a trend toward FOLFOX induced amenorrhea during chemotherapy increasing with age. Twenty-four percent of women older than the age of 40 were found to have persistent amenorrhea after FOLFOX therapy. Because of the small sample size, the study is underpowered to detect a statistically significant difference between older and younger patients. Prospective studies

Music therapy for mood disturbance during hospitalization for autologous stem cell transplantation: a randomized controlled trial.

Science.gov (United States)

Cassileth, Barrie R; Vickers, Andrew J; Magill, Lucanne A

2003-12-15

High-dose therapy with autologous stem cell transplantation (HDT/ASCT) is a commonly used treatment for hematologic malignancies. The procedure causes significant psychological distress and no interventions have been demonstrated to improve mood in these patients. Music therapy has been shown to improve anxiety in a variety of acute medical settings. In the current study, the authors determined the effects of music therapy compared with standard care on mood during inpatient stays for HDT/ASCT. Patients with hematologic malignancy admitted for HDT/ASCT at two sites (Memorial Sloan-Kettering Cancer Center and Ireland Cancer Center in Cleveland, Ohio) were randomized to receive music therapy given by trained music therapists or standard care. Outcome was assessed at baseline and every 3 days after randomization using the Profile of Mood States. Of 69 patients registered in the study, follow-up data were available for 62 (90%). During their inpatient stay, patients in the music therapy group scored 28% lower on the combined Anxiety/Depression scale (P = 0.065) and 37% lower (P = 0.01) on the total mood disturbance score compared with controls. Music therapy is a noninvasive and inexpensive intervention that appears to reduce mood disturbance in patients undergoing HDT/ASCT. Copyright 2003 American Cancer Society.

Prognostic relevance of sunitinib toxicities and comparison of continuous vs. intermittent sunitinib dosing schedule in metastatic renal cell cancer patients

Directory of Open Access Journals (Sweden)

Çetin Ordu

2016-06-01

Full Text Available Aim of the study : Sunitinib-related side effects may develop as a result of the pharmacokinetic pathway affects the of the drug. Material and methods : Data on mRCC patients were obtained from the hospital archives. Outcomes of patients were evaluated in terms of related prognostic factors, sunitinib adverse events during the treatment, and two different sunitinib dosing schedules. Results : Seventy patients diagnosed with mRCC and treated with sunitinib were analyzed for prognostic factors and survival rates. During the mean follow-up of 33.5 months, 38 (54% patients were alive and 32 (46% patients died. The median time of overall survival (OS and progression-free survival (PFS was 27 months (12–61 and 19 months (5–45, respectively. In univariate analysis, good prognostic risk group according to the Memorial Sloan-Kettering Cancer Center (MSKCC, hypothyroidism as sunitinib toxicity and patients on sunitinib treatment more than 1 year were favorable prognostic factors for OS. Leukopenia and fatigue as sunitinib toxicity were poor prognostic factors for OS. PFS and OS of the patients were not significantly different when we compared intermittent (4/2 vs. continuous treatment dosing schedules. Conclusions : As a result of this trial, having hypothyroidism as an adverse effect of sunitinib was a favorable prognostic factor for OS and PFS in mRCC patients. It was also found that 4/2 and continuous dosing schedules of sunitinib did not give rise to different outcomes in mRCC patients.

Improving cancer treatment with cyclotron produced radionuclides

International Nuclear Information System (INIS)

Laughlin, J.S.; Larson, S.M.

1988-01-01

This new DOE proposal appropriately builds on past developments. The development and application of radionuclides for diagnosis, treatment and research has been a continuing concern for more than the past three decades. A brief description of this development and previous achievements was considered important in order to provide a frame of reference for the evolving program here. Earlier, the use of certain radionuclides, radon progeny and I-131 in particular, and also x-rays, had been developed by the work of such pioneers as Failla, Quimby and Marinelli. In 1952, at the instigation of Dr. C.P. Rhoads, Director of both Memorial Hospital and Sloan-Kettering Institute, the restoration of the Department of Physics and Biophysics was undertaken in response to a perceived need to promote the utilization of radionuclides and of high energy radiations for therapeutic, diagnostic and research purposes. This resulted in several research and developmental projects with close clinical collaboration in areas of radiation treatment; medical studies with radionuclides and labeled compounds; the diagnostic uses of x-rays; and some projects in surgery and other clinical areas. Aspects of some of these projects that have had some relevance for the evolving AEC-DOE projects are outlined briefly. 34 refs

Reliability and validity of a survey to measure bowel function and quality of life in long-term rectal cancer survivors.

Science.gov (United States)

Wendel, Christopher S; Grant, Marcia; Herrinton, Lisa; Temple, Larissa K F; Hornbrook, Mark C; McMullen, Carmit K; Bulkley, Joanna E; Altschuler, Andrea; Krouse, Robert S

2014-12-01

Examination of reliability and validity of a specialized health-related quality of life questionnaire for rectal cancer (RC) survivors (≥5 years post-diagnosis). We mailed 1,063 Kaiser Permanente (KP) RC survivors (313 ostomy and 750 anastomosis) a questionnaire containing the Modified City of Hope Quality of Life-Ostomy (mCOH-QOL-O), SF-12v2, Duke-UNC Functional Social Support Questionnaire (FSSQ), and Memorial Sloan-Kettering Cancer Center Bowel Function Index (BFI). We adapted certain BFI items for use by subjects with intestinal ostomies. We evaluated reliability for all instruments with inter-item correlations and Cronbach's alpha. We assessed construct validity only for the BFI in the ostomy group, because such use has not been reported. The overall response rate was 60.5 % (577 respondents/953 eligible). Compared with non-responders, participants were on average 2 years younger and more likely non-Hispanic white, resided in educationally non-deprived areas, and had KP membership through a group. The mCOH-QOL-O, SF-12, and FSSQ were found to be highly reliable for RC survivors. In the ostomy group, BFI Urgency/Soilage and Dietary subscales were found to be reliable, but Frequency was not. Factor analysis supported the construct of Urgency/Soilage and Dietary subscales in the ostomy group, although one item had a moderate correlation with all three factors. The BFI also demonstrated good concurrent validity with other instruments in the ostomy group. With possible exception of the BFI Frequency subscale in populations with ostomies, components of our survey can be used for the entire population of RC survivors, no matter whether they received anastomosis or ostomy.

Sloan foundation nuclear education program

International Nuclear Information System (INIS)

Kursunoglu, B.N.

1992-01-01

The Alfred P. Sloan Foundation realized the time had come for a real and significant contribution to the enlightenment of university students concerning nuclear matters. The Sloan Foundation chose to educate the youth of four-year colleges and universities with a curriculum established with the resource information sieved from three workshops for professors in these institutions. The three workshops were organized by groups at Harvard-MIT (two-week Summer Program on Nuclear Weapons and Arms Control), the University of California, San Diego (two-week Summer Seminar on Global Security and Arms Control), and the University of Miami (one-week Winter Workshop on Enlightenment: The Best Security in a Nuclear-Armed World). In this report the author focuses on a unified presentation of the basic facts, aims, and results of the Sloan Foundation Nuclear Education Program based on three workshops directed by Jack Ruina (MIT), Herbert York (USCD), and Behram Kursunoglu (UM) and offered from 1983-1990

A score system for complete cytoreduction in selected recurrent ovarian cancer patients undergoing secondary cytoreductive surgery: predictors- and nomogram-based analyses.

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Bogani, Giorgio; Tagliabue, Elena; Signorelli, Mauro; Ditto, Antonino; Martinelli, Fabio; Chiappa, Valentina; Mosca, Lavinia; Sabatucci, Ilaria; Leone Roberti Maggiore, Umberto; Lorusso, Domenica; Raspagliesi, Francesco

2018-05-01

To test the applicability of the Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) and Memorial Sloan Kettering (MSK) criteria in predicting complete cytoreduction (CC) in patients undergoing secondary cytoreductive surgery (SCS) for recurrent ovarian cancer (ROC). Data of consecutive patients undergoing SCS were reviewed. The Arbeitsgemeinschaft Gynäkologische Onkologie OVARian cancer study group (AGO-OVAR) and MSK criteria were retrospectively applied. Nomograms, based on AGO criteria, MSK criteria and both AGO and MSK criteria were built in order to assess the probability to achieve CC at SCS. Overall, 194 patients met the inclusion criteria. CC was achieved in 161 (82.9%) patients. According to the AGO-OVAR criteria, we observed that CC was achieved in 87.0% of patients with positive AGO score. However, 45 out of 71 (63.4%) patients who did not fulfilled the AGO score had CC. Similarly, CC was achieved in 87.1%, 61.9% and 66.7% of patients for whom SCS was recommended, had to be considered and was not recommended, respectively. In order to evaluate the predictive value of the AGO-OVAR and MSK criteria we built 2 separate nomograms (c-index: 0.5900 and 0.5989, respectively) to test the probability to achieve CC at SCS. Additionally, we built a nomogram using both the aforementioned criteria (c-index: 0.5857). The AGO and MSK criteria help identifying patients deserving SCS. However, these criteria might be strict, thus prohibiting a beneficial treatment in patients who do not met these criteria. Further studies are needed to clarify factors predicting CC at SCS. Copyright © 2018. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology.

In vivo neutron activation at the Sloan-Kettering Institute

International Nuclear Information System (INIS)

Bigler, R.E.

1986-01-01

A medical cyclotron (Model CS-15, The Cyclotron Corporation, Berkeley, CA) with a multi-layer neutron collimator designed for partial body neutron irradiations and a low-background patient counting facility have been established for measurement of bone calcium and sodium; and soft tissue, exchangeable sodium and chlorine. The cyclotron also provides total-body calcium by the 37 Ar method of Palmer. (author)

The role of parotid gland irradiation in the development of severe hyposalivation (xerostomia) after intensity-modulated radiation therapy for head and neck cancer: Temporal patterns, risk factors, and testing the QUANTEC guidelines.

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Owosho, Adepitan A; Thor, Maria; Oh, Jung Hun; Riaz, Nadeem; Tsai, C Jillian; Rosenberg, Haley; Varthis, Spyridon; Yom, Sae Hee K; Huryn, Joseph M; Lee, Nancy Y; Deasy, Joseph O; Estilo, Cherry L

2017-04-01

The aims of this study were to investigate temporal patterns and potential risk factors for severe hyposalivation (xerostomia) after intensity-modulated radiotherapy (IMRT) for head and neck cancer (HNC), and to test the two QUANTEC (Quantitative Analysis of Normal Tissue Effects in the Clinic) guidelines. Sixty-three patients treated at the Memorial Sloan Kettering Cancer Center between 2006 and 2015, who had a minimum of three stimulated whole mouth saliva flow measurements (WMSFM) at a median follow-up time of 11 (range: 3-24) months were included. Xerostomia was defined as WMSFM ≤25% compared to relative pre-radiotherapy. Patients were stratified into three follow-up groups: 1: xerostomia was 27%, 14% and 17% at follow-up time points 1, 2 and 3, respectively. At xerostomia (Dmean contra : 25 Gy vs. 15 Gy; Dmean ipsi : 44 Gy vs. 25 Gy). Patients with xerostomia had higher pre-RT WMSFM (3.5 g vs. 2.4 g), and had been treated more frequently with additional chemotherapy (93% vs. 63%; all 4 variables: p xerostomia was higher compared to patients without (26 Gy vs. 20 Gy). The RR as specified by the one- and two-gland QUANTEC guideline was 2.3 and 1.4 for patients with Xerostomia following IMRT peaks within six months post-radiotherapy and fades with time. Limiting the mean dose to both parotid glands (ipsilateral xerostomia. Both QUANTEC guidelines are effective in preventing xerostomia. Copyright © 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Cancer immunotherapy and immunological memory.

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Murata, Kenji; Tsukahara, Tomohide; Torigoe, Toshihiko

2016-01-01

Human immunological memory is the key distinguishing hallmark of the adaptive immune system and plays an important role in the prevention of morbidity and the severity of infection. The differentiation system of T cell memory has been clarified using mouse models. However, the human T cell memory system has great diversity induced by natural antigens derived from many pathogens and tumor cells throughout life, and profoundly differs from the mouse memory system constructed using artificial antigens and transgenic T cells. We believe that only human studies can elucidate the human immune system. The importance of immunological memory in cancer immunotherapy has been pointed out, and the trafficking properties and long-lasting anti-tumor capacity of memory T cells play a crucial role in the control of malignant tumors. Adoptive cell transfer of less differentiated T cells has consistently demonstrated superior anti-tumor capacity relative to more differentiated T cells. Therefore, a human T cell population with the characteristics of stem cell memory is thought to be attractive for peptide vaccination and adoptive cell transfer. A novel human memory T cell population that we have identified is closer to the naive state than previous memory T cells in the T cell differentiation lineage, and has the characteristics of stem-like chemoresistance. Here we introduce this novel population and describe the fundamentals of immunological memory in cancer immunotherapy.

Identification of Germline Genetic Mutations in Pancreatic Cancer Patients

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Salo-Mullen, Erin E.; O’Reilly, Eileen; Kelsen, David; Ashraf, Asad M.; Lowery, Maeve; Yu, Kenneth; Reidy, Diane; Epstein, Andrew S.; Lincoln, Anne; Saldia, Amethyst; Jacobs, Lauren M.; Rau-Murthy, Rohini; Zhang, Liying; Kurtz, Robert; Saltz, Leonard; Offit, Kenneth; Robson, Mark; Stadler, Zsofia K.

2016-01-01

Background Pancreatic adenocarcinoma (PAC) is part of several cancer predisposition syndromes; however, indications for genetic counseling/testing are not well-defined. We sought to determine mutation prevalence and characteristics that predict for inherited predisposition to PAC. Methods We identified 175 consecutive PAC patients who underwent clinical genetics assessment at Memorial Sloan Kettering between 2011–2014. Clinical data, family history, and germline results were evaluated. Results Among 159 PAC patients who pursued genetic testing, 24 pathogenic mutations were identified (15.1%; 95%CI, 9.5%–20.7%), including BRCA2(n=13), BRCA1(n=4), p16(n=2), PALB2(n=1), and Lynch syndrome(n=4). BRCA1/BRCA2 prevalence was 13.7% in Ashkenazi Jewish(AJ) (n=95) and 7.1% in non-AJ(n=56) patients. In AJ patients with strong, weak, or absent family history of BRCA-associated cancers, mutation prevalence was 16.7%, 15.8%, and 7.4%, respectively. Mean age at diagnosis in all mutation carriers was 58.5y(range 45–75y) compared to 64y(range 27–87y) in non-mutation carriers(P=0.02). Although BRCA2 was the most common mutation identified, no patients with early-onset PAC(≤50y) harbored a BRCA2 mutation and the mean age at diagnosis in BRCA2 carriers was equivalent to non-mutation carriers(P=0.34). Mutation prevalence in early-onset patients(n=21) was 28.6%, including BRCA1(n=2), p16(n=2), MSH2(n=1) and MLH1(n=1). Conclusion Mutations in BRCA2 account for over 50% of PAC patients with an identified susceptibility syndrome. AJ patients had high BRCA1/BRCA2 prevalence regardless of personal/family history, suggesting that ancestry alone indicates a need for genetic evaluation. With the exception of BRCA2-associated PAC, inherited predisposition to PAC is associated with earlier age at PAC diagnosis suggesting that this subset of patients may also represent a population warranting further evaluation. PMID:26440929

Tumor mutational load and immune parameters across metastatic Renal Cell Carcinoma (mRCC) risk groups

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de Velasco, Guillermo; Miao, Diana; Voss, Martin H.; Hakimi, A. Ari; Hsieh, James J.; Tannir, Nizar M.; Tamboli, Pheroze; Appleman, Leonard J.; Rathmell, W. Kimryn; Van Allen, Eliezer M.; Choueiri, Toni K.

2016-01-01

Patients with metastatic renal cell carcinoma (mRCC) have better overall survival when treated with nivolumab, a cancer immunotherapy that targets the immune checkpoint inhibitor programmed cell death 1 (PD-1), rather than everolimus (a chemical inhibitor of mTOR and immunosuppressant). Poor-risk mRCC patients treated with nivolumab seemed to experience the greatest overall survival benefit, compared to patients with favorable or intermediate-risk, in an analysis of the CheckMate-025 trial subgroup of the Memorial Sloan Kettering Cancer Center (MSKCC) prognostic risk groups. Here we explore whether tumor mutational load and RNA expression of specific immune parameters could be segregated by prognostic MSKCC risk strata and explain the survival seen in the poor-risk group. We queried whole exome transcriptome data in RCC patients (n = 54) included in The Cancer Genome Atlas that ultimately developed metastatic disease or were diagnosed with metastatic disease at presentation and did not receive immune checkpoint inhibitors. Nonsynonymous mutational load did not differ significantly by MSKCC risk group, nor was the expression of cytolytic genes –granzyme A and perforin – or selected immune checkpoint molecules different across MSKCC risk groups. In conclusion, this analysis found that mutational load and expression of markers of an active tumor microenvironment did not correlate with MSKCC risk prognostic classification in mRCC. PMID:27538576

A. P. Sloan Jr. and leadership

Directory of Open Access Journals (Sweden)

Paul Marinescu

2014-05-01

Full Text Available Organizing the manufacturing processes constituted probably the most difficult challenge in the American automotive industry in the 1920s. A. P. Sloan Jr. was one of the greatest captains of industry and shaped General Motors Corporation into the largest automotive manufacturer of the world. His creative approach on how to mix a degree of decentralized responsibility with centralized control remains a useful example for every corporate leader. The aim of our paper is to emphasize the contribution of Sloan Jr. to the development of leadership. The methodological approach is literature review.

Association of statin use with a pathologic complete response to neoadjuvant chemoradiation for rectal cancer

International Nuclear Information System (INIS)

Katz, Matthew S.; Minsky, Bruce D.; Saltz, Leonard B.; Riedel, Elyn; Chessin, David B.; Guillem, Jose G.

2005-01-01

Purpose: To assess whether 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, might enhance the efficacy of neoadjuvant chemoradiation in rectal cancer. Methods and Materials: Between 1996 and 2001, 358 patients with clinically resectable, nonmetastatic rectal cancer underwent surgery at Memorial Sloan-Kettering Cancer Center after neoadjuvant chemoradiation for either locally advanced tumors or low-lying tumors that would require abdominoperineal resection. We excluded 9 patients for radiation therapy dose <45 Gy or if statin use was unknown, leaving 349 evaluable patients. Median radiation therapy dose was 50.4 Gy (range, 45-55.8 Gy), and 308 patients (88%) received 5-flurouracil-based chemotherapy. Medication use, comorbid illnesses, clinical stage as assessed by digital rectal examination and ultrasound, and type of chemotherapy were analyzed for associations with pathologic complete response (pCR), defined as no microscopic evidence of tumor. Fisher's exact test was used for categoric variables, Mantel-Haenszel test for ordered categoric variables, and logistic regression for multivariate analysis. Results: Thirty-three patients (9%) used a statin, with no differences in clinical stage according to digital rectal examination or ultrasound compared with the other 324 patients. At the time of surgery, 23 nonstatin patients (7%) were found to have metastatic disease, compared with 0% for statin patients. The unadjusted pCR rates with and without statin use were 30% and 17%, respectively (p = 0.10). Variables significant univariately at the p = 0.15 level were entered into a multivariate model, as were nonsteroidal anti-inflammatory drugs (NSAIDs), which were strongly associated with statin use. The odds ratio for statin use on pCR was 4.2 (95% confidence interval, 1.7-12.1; p = 0.003) after adjusting for NSAID use, clinical stage, and type of chemotherapy. Conclusion: In multivariate analysis, statin use is associated with an improved p

Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing.

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Mandelker, Diana; Zhang, Liying; Kemel, Yelena; Stadler, Zsofia K; Joseph, Vijai; Zehir, Ahmet; Pradhan, Nisha; Arnold, Angela; Walsh, Michael F; Li, Yirong; Balakrishnan, Anoop R; Syed, Aijazuddin; Prasad, Meera; Nafa, Khedoudja; Carlo, Maria I; Cadoo, Karen A; Sheehan, Meg; Fleischut, Megan H; Salo-Mullen, Erin; Trottier, Magan; Lipkin, Steven M; Lincoln, Anne; Mukherjee, Semanti; Ravichandran, Vignesh; Cambria, Roy; Galle, Jesse; Abida, Wassim; Arcila, Marcia E; Benayed, Ryma; Shah, Ronak; Yu, Kenneth; Bajorin, Dean F; Coleman, Jonathan A; Leach, Steven D; Lowery, Maeve A; Garcia-Aguilar, Julio; Kantoff, Philip W; Sawyers, Charles L; Dickler, Maura N; Saltz, Leonard; Motzer, Robert J; O'Reilly, Eileen M; Scher, Howard I; Baselga, Jose; Klimstra, David S; Solit, David B; Hyman, David M; Berger, Michael F; Ladanyi, Marc; Robson, Mark E; Offit, Kenneth

2017-09-05

Guidelines for cancer genetic testing based on family history may miss clinically actionable genetic changes with established implications for cancer screening or prevention. To determine the proportion and potential clinical implications of inherited variants detected using simultaneous sequencing of the tumor and normal tissue ("tumor-normal sequencing") compared with genetic test results based on current guidelines. From January 2014 until May 2016 at Memorial Sloan Kettering Cancer Center, 10 336 patients consented to tumor DNA sequencing. Since May 2015, 1040 of these patients with advanced cancer were referred by their oncologists for germline analysis of 76 cancer predisposition genes. Patients with clinically actionable inherited mutations whose genetic test results would not have been predicted by published decision rules were identified. Follow-up for potential clinical implications of mutation detection was through May 2017. Tumor and germline sequencing compared with the predicted yield of targeted germline sequencing based on clinical guidelines. Proportion of clinically actionable germline mutations detected by universal tumor-normal sequencing that would not have been detected by guideline-directed testing. Of 1040 patients, the median age was 58 years (interquartile range, 50.5-66 years), 65.3% were male, and 81.3% had stage IV disease at the time of genomic analysis, with prostate, renal, pancreatic, breast, and colon cancer as the most common diagnoses. Of the 1040 patients, 182 (17.5%; 95% CI, 15.3%-19.9%) had clinically actionable mutations conferring cancer susceptibility, including 149 with moderate- to high-penetrance mutations; 101 patients tested (9.7%; 95% CI, 8.1%-11.7%) would not have had these mutations detected using clinical guidelines, including 65 with moderate- to high-penetrance mutations. Frequency of inherited mutations was related to case mix, stage, and founder mutations. Germline findings led to discussion or initiation of

Non-neoplastic parenchymal changes in kidney cancer and post-partial nephrectomy recovery of renal function.

Science.gov (United States)

Bazzi, Wassim M; Chen, Ling Y; Cordon, Billy H; Mashni, Joseph; Sjoberg, Daniel D; Bernstein, Melanie; Russo, Paul

2015-09-01

To explore the association of non-neoplastic parenchymal changes (nNPC) with patients' health and renal function recovery after partial nephrectomy (PN). This retrospective review identified 800 pT1a patients who underwent PN at Memorial Sloan Kettering Cancer Center from 2007 to 2012. Pathology reports were reviewed for nNPC graded as mild or severe: vascular sclerosis (VS), glomerulosclerosis (GS), and fibrosis/scarring. Correlations between nNPC and known preoperative predictors of renal function [age, sex, African-American race, estimated glomerular filtration rate (eGFR), American Society of Anesthesiologists (ASA) score, body mass index, coronary artery disease, and hypertension (HTN)] were assessed using Spearman's rank correlation (ρ). Multivariable linear regression, adjusted for the described known preoperative risk predictors, was performed to evaluate whether the parenchymal features were able to predict 6-month postoperative eGFR. In this study, 46 % of tumors had benign surrounding parenchyma. We noted statistically significant yet weak associations of VS with age (ρ = 0.19; p < 0.001), ASA (ρ = 0.09; p < 0.001), preoperative eGFR (ρ = -0.14; p < 0.001), and HTN (ρ = 0.14; p < 0.001). GS also significantly correlated with HTN, but the correlation was again small (ρ = 0.12; p < 0.001). After adjusting for known risk predictors, only GS was a significant predictor of 6-month postoperative eGFR. When compared with no GS, mild and severe GS were negatively associated with a decrease of 4.9 and 10.8 mL/min/1.73 m(2) in 6-month postoperative eGFR, respectively. Presence of VS and GS correlated with patients' baseline health, and presence of GS predicted postoperative renal function recovery.

Post-operative hemimaxillectomy rehabilitation using prostheses supported by zygoma implants and remaining natural teeth

Directory of Open Access Journals (Sweden)

Xing Zhou Qu

Full Text Available OBJECTIVES: This study aimed to evaluate the stability of prostheses supported by zygoma implants and remaining teeth for subjects who had undergone hemi-maxillectomy. METHODS: Ten patients were included in the study. Oral rehabilitation was performed using a temporary prosthesis that was supported by remaining teeth for the first three months. Then, a zygoma implant was placed to provide support for a final prosthesis in addition to the remaining teeth. Each prosthesis was tailor-made according to biomechanical three-dimensional finite element analysis results. The patients were assessed using the prosthesis functioning scale of the Memorial Sloan-Kettering Cancer Center. In addition, retention and bite force were recorded for both the temporary prosthesis and the final prosthesis. RESULTS: The mean bite force of the prosthetic first molar was increased to 69.2 N. The mean retentive force increased to 13.5 N after zygoma implant insertion. The bite force on the prosthetic first molar was improved to 229.3 N. CONCLUSION: Bite force increased significantly with the support of a zygoma implant. The use of zygoma implants in the restoration of maxillary defects improved functional outcome and patient satisfaction.

What is the gold standard for comprehensive interinstitutional communication of perioperative information for thyroid cancer patients? A comparison of existing electronic health records with the current American Thyroid Association recommendations.

Science.gov (United States)

Dos Reis, Laura L; Tuttle, R Michael; Alon, Eran; Bergman, Donald A; Bernet, Victor; Brett, Elise M; Cobin, Rhoda; Doherty, Gerard; Harris, Jeffrey R; Klopper, Joshua; Lee, Stephanie L; Lupo, Mark; Milas, Mira; Machac, Josef; Mechanick, Jeffrey I; Orloff, Lisa; Randolph, Gregory; Ross, Douglas S; Smallridge, Robert C; Terris, David James; Tufano, Ralph P; Mehra, Saral; Scherl, Sophie; Clain, Jason B; Urken, Mark L

2014-10-01

Appropriate management of well-differentiated thyroid cancer requires treating clinicians to have access to critical elements of the patient's presentation, surgical management, postoperative course, and pathologic assessment. Electronic health records (EHRs) provide an effective method for the storage and transmission of patient information, although most commercially available EHRs are not intended to be disease-specific. In addition, there are significant challenges for the sharing of relevant clinical information when providers involved in the care of a patient with thyroid cancer are not connected by a common EHR. In 2012, the American Thyroid Association (ATA) defined the critical elements for optimal interclinician communication in a position paper entitled, "The Essential Elements of Interdisciplinary Communication of Perioperative Information for Patients Undergoing Thyroid Cancer Surgery." We present a field-by-field comparison of the ATA's essential elements as applied to three contemporary electronic reporting systems: the Thyroid Surgery e-Form from Memorial Sloan-Kettering Cancer Center (MSKCC), the Alberta WebSMR from the University of Calgary, and the Thyroid Cancer Care Collaborative (TCCC). The MSKCC e-form fulfills 21 of 32 intraoperative fields and includes an additional 14 fields not specifically mentioned in the ATA's report. The Alberta WebSMR fulfills 45 of 82 preoperative and intraoperative fields outlined by the ATA and includes 13 additional fields. The TCCC fulfills 117 of 120 fields outlined by the ATA and includes 23 additional fields. Effective management of thyroid cancer is a highly collaborative, multidisciplinary effort. The patient information that factors into clinical decisions about thyroid cancer is complex. For these reasons, EHRs are particularly favorable for the management of patients with thyroid cancer. The MSKCC Thyroid Surgery e-Form, the Alberta WebSMR, and the TCCC each meet all of the general recommendations for

Internet Journal of Medical Update

African Journals Online (AJOL)

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This synoptic review of the pragmatic aspects of surgery will help students understand and remember better what they would have gleaned from weightier textbooks and formal lectures. The book is very readable, focused as it is on ... Sloan-Kettering, Dietl, Palomo and. Charcot, and non-English terms such as Sitz bath.

Design of multifunctional magnetic iron oxide nanoparticles/mitoxantrone-loaded liposomes for both magnetic resonance imaging and targeted cancer therapy

Directory of Open Access Journals (Sweden)

He Y

2014-08-01

Full Text Available Yingna He,1 Linhua Zhang,2 Dunwan Zhu,2 Cunxian Song2 1Laboratory of Chinese Medicine Pharmacology, College of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, People’s Republic of China; 2Key Laboratory of Biomedical Material of Tianjin, Institute of Biomedical Engineering, Peking Union Medical College and Chinese Academy of Medical Sciences, Tianjin, People’s Republic of China Abstract: Tumor-targeting multifunctional liposomes simultaneously loaded with magnetic iron oxide nanoparticles (MIONs as a magnetic resonance imaging (MRI contrast agent and anticancer drug, mitoxantrone (Mit, were developed for targeted cancer therapy and ultrasensitive MRI. The gonadorelin-functionalized MION/Mit-loaded liposome (Mit-GML showed significantly increased uptake in luteinizing hormone–releasing hormone (LHRH receptor overexpressing MCF-7 (Michigan Cancer Foundation-7 breast cancer cells over a gonadorelin-free MION/Mit-loaded liposome (Mit-ML control, as well as in an LHRH receptor low-expressing Sloan-Kettering HER2 3+ Ovarian Cancer (SK-OV-3 cell control, thereby leading to high cytotoxicity against the MCF-7 human breast tumor cell line. The Mit-GML formulation was more effective and less toxic than equimolar doses of free Mit or Mit-ML in the treatment of LHRH receptors overexpressing MCF-7 breast cancer xenografts in mice. Furthermore, the Mit-GML demonstrated much higher T2 enhancement than did Mit-ML controls in vivo. Collectively, the study indicates that the integrated diagnostic and therapeutic design of Mit-GML nanomedicine potentially allows for the image-guided, target-specific treatment of cancer. Keywords: multifunctional liposome, magnetic resonance imaging, theranostic nanomedicine, mitoxantrone, gonadorelin

WE-A-207-01: Memorial Lecturer

International Nuclear Information System (INIS)

Muller-Runkel, R

2015-01-01

The Medical Physics community lost one of its early pioneers in radiation oncology physics, Jacques Ovadia, who passed away in April of 2014 at the age of 90. Jacques received his Ph.D. in Nuclear Physics from the University of Illinois at Urbana in 1951. Subsequently, under the guidance of John Laughlin, he was introduced to the field of Medical Physics. When John moved to Memorial Sloan Kettering, Jacques followed him. There he gained clinical experience and expertise in the then cutting-edge field of high energy electron beam therapy. In 1956, Jacques joined Dr. Erich Uhlmann at Michael Reese Hospital in Chicago where one of the country’s first high energy medical linear accelerators had just been installed. During his 35 year tenure, Dr. Ovadia built a strong Medical Physics department that merged in 1984 with that of the University of Chicago. Jacques pioneered the use of high energy electron beams to treat deep seated tumors, multiple-field chest wall irradiation with variable electron energies, and even anticipated the current interest in high energy electron beam grid-therapy. At an early stage, he introduced a simulator, computerized treatment planning and in-house developed record and verify software. He retired in 1990 as Professor emeritus in Radiation and Cellular Biology at the University of Chicago. Dr. Ovadia was an early and strong supporter of AAPM. He was present at the Chicago ROMPS meeting where the decision was made to form an independent professional society for medical physics. He served as AAPM president in 1976. Jacques Ovadia is survived by his wife of 58 years, Florence, their daughter Corinne Graefe and son Marc Ovadia, MD, as well as four grandchildren and one great-grandchild. Jacques’ dynamic and ever enthusiastic personality inspired all who collaborated with him. He will be greatly missed

WE-A-207-01: Memorial Lecturer

Energy Technology Data Exchange (ETDEWEB)

Muller-Runkel, R [St. Margaret Mercy Healthcare Centers, Hammond, IN (United States)

2015-06-15

The Medical Physics community lost one of its early pioneers in radiation oncology physics, Jacques Ovadia, who passed away in April of 2014 at the age of 90. Jacques received his Ph.D. in Nuclear Physics from the University of Illinois at Urbana in 1951. Subsequently, under the guidance of John Laughlin, he was introduced to the field of Medical Physics. When John moved to Memorial Sloan Kettering, Jacques followed him. There he gained clinical experience and expertise in the then cutting-edge field of high energy electron beam therapy. In 1956, Jacques joined Dr. Erich Uhlmann at Michael Reese Hospital in Chicago where one of the country’s first high energy medical linear accelerators had just been installed. During his 35 year tenure, Dr. Ovadia built a strong Medical Physics department that merged in 1984 with that of the University of Chicago. Jacques pioneered the use of high energy electron beams to treat deep seated tumors, multiple-field chest wall irradiation with variable electron energies, and even anticipated the current interest in high energy electron beam grid-therapy. At an early stage, he introduced a simulator, computerized treatment planning and in-house developed record and verify software. He retired in 1990 as Professor emeritus in Radiation and Cellular Biology at the University of Chicago. Dr. Ovadia was an early and strong supporter of AAPM. He was present at the Chicago ROMPS meeting where the decision was made to form an independent professional society for medical physics. He served as AAPM president in 1976. Jacques Ovadia is survived by his wife of 58 years, Florence, their daughter Corinne Graefe and son Marc Ovadia, MD, as well as four grandchildren and one great-grandchild. Jacques’ dynamic and ever enthusiastic personality inspired all who collaborated with him. He will be greatly missed.

Maximal safe dose of I-131 after failure of standard fixed dose therapy in patients with differentiated thyroid carcinoma

International Nuclear Information System (INIS)

Lee, Jong-Jin; Chung, June-Key; Kim, Sung-Eun; Kang, Won-Jun; Park, Do-Joon; Lee, Dong-Soo; Cho, Bo-Youn; Lee, Myung-Chul

2008-01-01

The maximal safe dose (MSD) on the basis of bone marrow irradiation levels allows the delivery of a large amount of I-131 to thyroid cancer tissue. The efficacy of MSD therapy in differentiated metastatic thyroid cancers that persisted after conventional fixed dose therapy is investigated. Forty-seven differentiated thyroid carcinoma patients with non-responsive residual disease despite repetitive fixed dose I-131 therapy were enrolled in this study. Their postoperative pathologies were 43 papillary carcinomas and 4 follicular carcinomas. The MSD was calculated with the Memorial Sloan-Kettering Cancer Center protocol using serial blood samples. The MSDs were administered at intervals of 6 months. Treatment responses were evaluated using I-131 whole-body scans and serum thyroglobulin measurements. The mean calculated MSD was 12.5±2.1 GBq (339.6±57.5 mCi). Of the 46 patients, 7 (14.9%) showed complete remission, 15 (31.9%) partial remission, 19 (40.4%) stable disease, and 6 (12.8%) disease progression. Of the patients who showed complete or partial remission, 15 (65%) showed response after the first MSD session and 6 (26%) showed response after the second session. Twenty-nine patients (62%) experienced transient cytopenia after therapy, but three did not recover to the baseline level. The maximal safe dose provides an effective means of treatment in patients who failed to respond adequately to conventional fixed dose therapy. I-131 MSD therapy can be considered in patients who fail fixed dose therapy. (author)

Using generalized equivalent uniform dose atlases to combine and analyze prospective dosimetric and radiation pneumonitis data from 2 non-small cell lung cancer dose escalation protocols.

Science.gov (United States)

Liu, Fan; Yorke, Ellen D; Belderbos, José S A; Borst, Gerben R; Rosenzweig, Kenneth E; Lebesque, Joos V; Jackson, Andrew

2013-01-01

To demonstrate the use of generalized equivalent uniform dose (gEUD) atlas for data pooling in radiation pneumonitis (RP) modeling, to determine the dependence of RP on gEUD, to study the consistency between data sets, and to verify the increased statistical power of the combination. Patients enrolled in prospective phase I/II dose escalation studies of radiation therapy of non-small cell lung cancer at Memorial Sloan-Kettering Cancer Center (MSKCC) (78 pts) and the Netherlands Cancer Institute (NKI) (86 pts) were included; 10 (13%) and 14 (17%) experienced RP requiring steroids (RPS) within 6 months after treatment. gEUD was calculated from dose-volume histograms. Atlases for each data set were created using 1-Gy steps from exact gEUDs and RPS data. The Lyman-Kutcher-Burman model was fit to the atlas and exact gEUD data. Heterogeneity and inconsistency statistics for the fitted parameters were computed. gEUD maps of the probability of RPS rate≥20% were plotted. The 2 data sets were homogeneous and consistent. The best fit values of the volume effect parameter a were small, with upper 95% confidence limit around 1.0 in the joint data. The likelihood profiles around the best fit a values were flat in all cases, making determination of the best fit a weak. All confidence intervals (CIs) were narrower in the joint than in the individual data sets. The minimum P value for correlations of gEUD with RPS in the joint data was .002, compared with P=.01 and .05 for MSKCC and NKI data sets, respectively. gEUD maps showed that at small a, RPS risk increases with gEUD. The atlas can be used to combine gEUD and RPS information from different institutions and model gEUD dependence of RPS. RPS has a large volume effect with the mean dose model barely included in the 95% CI. Data pooling increased statistical power. Copyright © 2013 Elsevier Inc. All rights reserved.

Erratum: Sloan Magnitudes for the Brightest Stars

Science.gov (United States)

Mallama, A.

2018-06-01

In the article "Sloan Magnitudes for the Brightest Stars" (JAAVSO, 2014, 42, 443), Equation 3 in section A.1. of the Appendix is incorrect; the coefficient of ((R-I) - C1) should be 0.935, rather than 0.953. The mean differences between the new and old results are 0.00 in all cases, and the standard deviations are all 0.00 or 0.01, which is less than the photometric uncertainties of the Johnson or Sloan values. A revised version of the catalog has been published at https://arxiv.org/abs/1805.09324. The revision is proposed as a bright star extension to the APASS database.

Conformal radiotherapy to 76 Gy in localized prostate cancer. Therapeutic modalities and preliminary results

International Nuclear Information System (INIS)

Pontvert, D.; Mammar, H.; Flam, T.; Debre, B.; Thiounn, N.; Gaboriaud, G.; Jourdan-Da Silvae, N.; Beuzeboc, P.

2008-01-01

Purpose: to describe therapeutic modalities for localized prostate cancer treated by conformal radiation to 76 Gy with or without androgen ablation. To evaluate the preliminary results in terms of survival, biological control and toxicity. Patients and method: between January 1998 and June 2001, 321 patients with localized prostate cancer were irradiated at Institut Curie. Tumors were stratified into the three Memorial Sloan-Kettering Cancer Center prognostic groups (1998) for analysis: favorable risk group (F.G.) 23%, intermediate risk group (I.G.) 36.5%, unfavorable risk group (U.G.) 40.5%. Androgen deprivation, mainly neo-adjuvant, less or equal to one year was prescribed to 93.8% of patients (72.6% less or equal to six months). Planning target volume prescription doses were: prostate: 76 Gy, seminal vesicles: 56 to 76 Gy, and pelvic lymph nodes: 44 Gy to 16.8% of patients. Results: the five-year actuarial overall survival was 94% (95% I.C.: 90-97%). The median post-therapeutic follow-up was 36 months (nine to 60 months). The 48-month actuarial rates of biochemical control for the three prognostic groups were statistically different according to both the American Society for Therapeutic Radiology and Oncology consensus (A.S.T.R.O. 1997) and the Fox Chase Cancer Center definitions of biochemical failure (F.C.C.C. 2000) with respectively 87 and 94% for F.G., 78 and 84% for I.G., 54 and 58% for U.G. (P < 10-6 and P < 10-8). At time of our analysis, late post-treatment rectal and bladder bleedings were 17,4 and 13,6%, respectively. According to a 1-4 scale adapted from M.D. Anderson Cancer Center criteria: rectal bleedings were grade 1 (9.6%), grade 2 (6.2%) and grade 3 (1.6%). Bladder bleedings were grade 2 (13%) and grade 3 (0.6%). Analysis of rectal bleeding risk factors showed significant correlations with pelvic lymph nodes irradiation for grade 2 and 3, (P = 0.02), and for all grades, a correlation with smaller rectal wall volumes (P = 0.03), and greater

Testing a novel account of the dissociation between self-reported memory problems and memory performance in chemotherapy-treated breast cancer survivors.

Science.gov (United States)

Paquet, Lise; Verma, Shailendra; Collins, Barbara; Chinneck, Anne; Bedard, Marc; Song, Xinni

2018-01-01

A puzzling observation pertaining to the impact of breast cancer on memory is the frequently reported dissociation between breast cancer survivors' self-reported memory problems and memory performance. We evaluated the hypothesis that the dissociation is related to the fact that the objective memory measures previously used assessed retrospective memory (RM) and did not tap prospective memory (PM), a domain about which survivors are complaining. In a case-healthy-control (N = 80) cross-sectional study, the Memory for Intention Screening Test was used to assess PM and the Wechsler Logical Memory Test was used to evaluate RM. Self-reported problems were assessed with the Prospective and Retrospective Memory Questionnaire. Measures of depression (Center for Epidemiologic Studies Depression Scale) and fatigue (Functional Assessment of Cancer Therapy: Fatigue) were also administered. Both groups reported more PM than RM problems (P memory problems than controls (all P memory problems. Although unrelated to performance, memory complaints should not be dismissed, as they are closely associated with depression and fatigue and reveal an important facet of the cancer experience. Copyright © 2017 John Wiley & Sons, Ltd.

TRASH TO TREASURE: CONVERTING COLD WAR LEGACY WASTE INTO WEAPONS AGAINST CANCER

International Nuclear Information System (INIS)

Nicholas, R.G.; Lacy, N.H.; Butz, T.R.; Brandon, N.E.

2004-01-01

As part of its commitment to clean up Cold War legacy sites, the U.S. Department of Energy (DOE) has initiated an exciting and unique project to dispose of its inventory of uranium-233 (233U) stored at Oak Ridge National Laboratory (ORNL), and extract isotopes that show great promise in the treatment of deadly cancers. In addition to increasing the supply of potentially useful medical isotopes, the project will rid DOE of a nuclear concern and cut surveillance and security costs. For more than 30 years, DOE's ORNL has stored over 1,200 containers of fissile 233U, originally produced for several defense-related projects, including a pilot study that looked at using 233U as a commercial reactor fuel. This uranium, designated as special nuclear material, requires expensive security, safety, and environmental controls. It has been stored at an ORNL facility, Building 3019A, that dates back to the Manhattan Project. Down-blending the material to a safer form, rather than continuing to store it, will eliminate a $15 million a year financial liability for the DOE and increase the supply of medical isotopes by 5,700 percent. During the down-blending process, thorium-229 (229Th) will be extracted. The thorium will then be used to extract actinium-225 (225Ac), which will ultimately supply its progeny, bismuth-213 (213Bi), for on-going cancer research. The research includes Phase II clinical trials for the treatment of acute myelogenous leukemia at Sloan-Kettering Memorial Cancer Center in New York, as well as other serious cancers of the lungs, pancreas, and kidneys using a technique known as alpha-particle radioimmunotherapy. Alpha-particle radioimmunotherapy is based on the emission of alpha particles by radionuclides. 213Bi is attached to a monoclonal antibody that targets specific cells. The bismuth then delivers a high-powered but short-range radiation dose, effectively killing the cancerous cells but sparing the surrounding tissue. Production of the actinium and

Ewing sarcoma in adults treated with modern radiotherapy techniques

International Nuclear Information System (INIS)

Casey, Dana L.; Meyers, Paul A.; Alektiar, Kaled M.; Magnan, Heather; Healey, John H.; Boland, Patrick J.; Wolden, Suzanne L.

2014-01-01

Background and purpose: To evaluate local control and survival outcomes in adults with Ewing sarcoma (ES) treated with radiotherapy (RT). Material and methods: Retrospective review of all 109 patients age ⩾18 treated for ES with RT to the primary site at Memorial Sloan Kettering Cancer Center between 1990 and 2011. RT was used as the definitive local control modality in 44% of patients, preoperatively for 6%, and postoperatively for 50%. Results: Median age at diagnosis was 27 years (range, 18–67). The 5-year local failure (LF) was 18%. Differences in LF were not identified when evaluated by modality of local control (RT versus combined surgery and RT), RT dose, fractionation, and RT technique. However, margin status at time of resection significantly predicted LF. The 5-year event-free survival and overall survival rates were 44% and 66% for patients with localized disease, compared with 16% and 26% for metastatic disease (p = 0.0005 and 0.0002). Tumor size, histopathologic response to chemotherapy, and treatment on or according to a protocol were also significantly associated with survival. Conclusions: This series of adults treated with modern chemotherapy and RT had prognostic factors and outcomes similar to adolescents with ES. All adults with ES should be treated with an aggressive, multidisciplinary approach

Whole Blood mRNA Expression-Based Prognosis of Metastatic Renal Cell Carcinoma.

Science.gov (United States)

Giridhar, Karthik V; Sosa, Carlos P; Hillman, David W; Sanhueza, Cristobal; Dalpiaz, Candace L; Costello, Brian A; Quevedo, Fernando J; Pitot, Henry C; Dronca, Roxana S; Ertz, Donna; Cheville, John C; Donkena, Krishna Vanaja; Kohli, Manish

2017-11-03

The Memorial Sloan Kettering Cancer Center (MSKCC) prognostic score is based on clinical parameters. We analyzed whole blood mRNA expression in metastatic clear cell renal cell carcinoma (mCCRCC) patients and compared it to the MSKCC score for predicting overall survival. In a discovery set of 19 patients with mRCC, we performed whole transcriptome RNA sequencing and selected eighteen candidate genes for further evaluation based on associations with overall survival and statistical significance. In an independent validation of set of 47 patients with mCCRCC, transcript expression of the 18 candidate genes were quantified using a customized NanoString probeset. Cox regression multivariate analysis confirmed that two of the candidate genes were significantly associated with overall survival. Higher expression of BAG1 [hazard ratio (HR) of 0.14, p < 0.0001, 95% confidence interval (CI) 0.04-0.36] and NOP56 (HR 0.13, p < 0.0001, 95% CI 0.05-0.34) were associated with better prognosis. A prognostic model incorporating expression of BAG1 and NOP56 into the MSKCC score improved prognostication significantly over a model using the MSKCC prognostic score only ( p < 0.0001). Prognostic value of using whole blood mRNA gene profiling in mCCRCC is feasible and should be prospectively confirmed in larger studies.

A Prospective Study of Autobiographical Memory and Posttraumatic Stress Disorder Following Cancer

Science.gov (United States)

Kangas, Maria; Henry, Jane L.; Bryant, Richard A.

2005-01-01

In this study, the authors investigated the relationship between autobiographical memory and the onset and maintenance of distressing memories following cancer. In Study 1, participants recently diagnosed with head, neck, or lung cancer were assessed for acute stress disorder (ASD). Participants with ASD reported fewer specific memories than did…

A conversation with Susan Band Horwitz.

Science.gov (United States)

Horwitz, Susan Band; Goldman, I David

2015-01-01

Susan Band Horwitz is a Distinguished Professor and holds the Falkenstein Chair in Cancer Research at Albert Einstein College of Medicine in New York. She is co-chair of the Department of Molecular Pharmacology and associate director for therapeutics at the Albert Einstein Cancer Center. After graduating from Bryn Mawr College, Dr. Horwitz received her PhD in biochemistry from Brandeis University. She has had a continuing interest in natural products as a source of new drugs for the treatment of cancer. Her most seminal research contribution has been in the development of Taxol(®). Dr. Horwitz and her colleagues made the discovery that Taxol had a unique mechanism of action and suggested that it was a prototype for a new class of antitumor drugs. Although Taxol was an antimitotic agent blocking cells in the metaphase stage of the cell cycle, Dr. Horwitz recognized that Taxol was blocking mitosis in a way different from that of other known agents. Her group demonstrated that the binding site for Taxol was on the β-tubulin subunit. The interaction of Taxol with the β-tubulin subunit resulted in stabilized microtubules, essentially paralyzing the cytoskeleton, thereby preventing cell division. Dr. Horwitz served as president (2002-2003) of the American Association for Cancer Research (AACR). She is a member of the National Academy of Sciences, the Institute of Medicine, the American Academy of Arts and Sciences, and the American Philosophical Society. She has received numerous honors and awards, including the C. Chester Stock Award from Memorial Sloan Kettering Cancer Center, the Warren Alpert Foundation Prize from Harvard Medical School, the Bristol-Myers Squibb Award for Distinguished Achievement in Cancer Research, the American Cancer Society's Medal of Honor, and the AACR Award for Lifetime Achievement in Cancer Research. The following interview was conducted on January 23, 2014.

Delirium in advanced age and dementia: A prolonged refractory course of delirium and lower functional status

Science.gov (United States)

BOETTGER, SOENKE; JENEWEIN, JOSEF; BREITBART, WILLIAM

2017-01-01

Objective The factors associated with persistent delirium, in contrast to resolved delirium, have not been studied well. The aim of our present study was to identify the factors associated with delirium resolution as measured by the Memorial Delirium Assessment Scale (MDAS) and functional improvement as measured by the Karnofsky Performance Status (KPS) scale. Method All subjects were recruited from psychiatric referrals at the Memorial Sloan Kettering Cancer Center (MSKCC). The two study instruments were performed at baseline (T1), at 2–3 days (T2), and at 4–7 days (T3). Subjects with persistent delirium were compared to those with resolved delirium in respect to sociodemographic and medical variables. Results Overall, 26 out of 111 patients had persistent delirium. These patients were older, predominantly male, and had more frequently preexisting comorbid dementia. Among cancer diagnoses and stage of illness, brain cancer and terminal illness contributed to persistent delirium or late response, whereas gastrointestinal cancer was associated with resolved delirium. Among etiologies, infection responded late to delirium management, usually at one week. Furthermore, delirium was more severe in patients with persistent delirium from baseline through one week. At baseline, MDAS scores were 20.1 in persistent delirium compared to 17 to 18.8 in resolved delirium (T2 and T3), and at one week of management (T3), MDAS scores were 15.2 and 4.7 to 7.4, respectively. At one week of management, persistent delirium manifested in more severe impairment in the domains of consciousness, cognition, organization, perception, psychomotor behavior, and sleep–wake cycle. In addition, persistent delirium caused more severe functional impairment. Significance of results In this delirium sample, advanced age and preexisting dementia, as well as brain cancer, terminal illness, infection, and delirium severity contributed to persistent delirium or late response, indicating a prolonged

Marijuana use and increased risk of squamous cell carcinoma of the head and neck.

Science.gov (United States)

Zhang, Z F; Morgenstern, H; Spitz, M R; Tashkin, D P; Yu, G P; Marshall, J R; Hsu, T C; Schantz, S P

1999-12-01

Marijuana is the most commonly used illegal drug in the United States. In some subcultures, it is widely perceived to be harmless. Although the carcinogenic properties of marijuana smoke are similar to those of tobacco, no epidemiological studies of the relationship between marijuana use and head and neck cancer have been published. The relationship between marijuana use and head and neck cancer was investigated by a case-control study of 173 previously untreated cases with pathologically confirmed diagnoses of squamous cell carcinoma of the head and neck and 176 cancer-free controls at Memorial Sloan-Kettering Cancer Center between 1992 and 1994. Epidemiological data were collected by using a structured questionnaire, which included history of tobacco smoking, alcohol use, and marijuana use. The associations between marijuana use and head and neck cancer were analyzed by Mantel-Haenszel methods and logistic regression models. Controlling for age, sex, race, education, alcohol consumption, pack-years of cigarette smoking, and passive smoking, the risk of squamous cell carcinoma of the head and neck was increased with marijuana use [odds ratio (OR) comparing ever with never users, 2.6; 95% confidence interval (CI), 1.1-6.6]. Dose-response relationships were observed for frequency of marijuana use/day (P for trend marijuana use (P for trend marijuana use were observed with cigarette smoking, mutagen sensitivity, and to a lesser extent, alcohol use. Our results suggest that marijuana use may increase the risk of head and neck cancer with a strong dose-response pattern. Our analysis indicated that marijuana use may interact with mutagen sensitivity and other risk factors to increase the risk of head and neck cancer. The results need to be interpreted with some caution in drawing causal inferences because of certain methodological limitations, especially with regard to interactions.

Pharmacology of bovine and human thyrotropin: an historical perspective.

Science.gov (United States)

Robbins, J

1999-05-01

Before the induction of a brief period of hypothyroidism became the standard method for inducing 131I uptake in thyroid cancer diagnosis and therapy, several other methods were explored and used. At the dawn of this new era of recombinant human thyrotropin (TSH) it is of interest to reflect briefly on some of this work. Partially purified bovine TSH (bTSH) was supplied for many years by the Armour Company as Thytropar for intramuscular injection and was first used in thyroid cancer 50 years ago at the Montefiore Hospital and at the Memorial Sloan Kettering Cancer Center in New York City. Most of the patients were already hypothyroid and bTSH induced further 131I uptake in only a few. Experience over the next 30 years revealed frequent allergic reactions, occasionally serious ones, and in 1961 it was shown that prolonged use could result in resistance to both bTSH and human TSH. bTSH was, therefore, reserved for thyroid cancer patients unable to increase endogenous TSH when hypothyroid. bTSH also was used widely as a test to distinguish between hypothyroidism caused by thyroid or pituitary failure until it was replaced by thyrotropin-releasing hormone (TRH). In a few studies, TRH was also tested as an adjuvant to increase endogenous TSH and thus help to stimulate function in thyroid cancer, but this attracted little interest. Prolonged hypothyroidism, enhanced by antithyroid drugs, was used early on, but this very effective stimulant of thyroid cancer function was, for multiple reasons, discarded. Beginning interest 15 to 25 years ago in obtaining TSH from human pituitary glands, a byproduct of growth hormone production, was interrupted when this product was found to risk development of Creutzfeld-Jakob disease. Recombinant human TSH, a safe and effective substitute, is now ready for widespread use and development in thyroid cancer management.

75 FR 22423 - Pick-Sloan Missouri Basin Program, Eastern and Western Division Proposed Project Use Power Rate

Science.gov (United States)

2010-04-28

...: Reopening of comment period for review of the Pick-Sloan Missouri Basin Program, Eastern and Western... reopening the comment period for the Pick-Sloan Missouri Basin Program, Eastern and Western Division... DEPARTMENT OF THE INTERIOR Bureau of Reclamation Pick-Sloan Missouri Basin Program, Eastern and...

75 FR 1408 - Pick-Sloan Missouri Basin Program, Eastern and Western Division Proposed Project Use Power Rate

Science.gov (United States)

2010-01-11

... of Proposed Pick-Sloan Missouri Basin Program, Eastern and Western Divisions, Project Use Power Rate...) for Project Use Power for the Pick-Sloan Missouri Basin Program (P-SMBP), Eastern and Western... DEPARTMENT OF THE INTERIOR Bureau of Reclamation Pick-Sloan Missouri Basin Program, Eastern and...

Validation and head-to-head comparison of three nomograms predicting probability of lymph node invasion of prostate cancer in patients undergoing extended and/or sentinel lymph node dissection

Energy Technology Data Exchange (ETDEWEB)

Grivas, Nikolaos; Wit, Esther; Tillier, Corinne; Muilekom, Erik van; Poel, Henk van der [The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Department of Urology, Amsterdam (Netherlands); Pos, Floris [The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Department of Radiation Oncology, Amsterdam (Netherlands); Winter, Alexander [School of Medicine and Health Sciences, Carl von Ossietzky University, University Hospital for Urology, Klinikum Oldenburg, Oldenburg (Germany)

2017-12-15

The updated Winter nomogram is the only nomogram predicting lymph node invasion (LNI) in prostate cancer (PCa) patients based on sentinel node (SN) dissection (sLND). The aim of the study was to externally validate the Winter nomogram and examine its performance in patients undergoing extended pelvic lymph node dissection (ePLND), ePLND combined with SN biopsy (SNB) and sLND only. The results were compared with the Memorial Sloan Kettering Cancer Center (MSKCC) and updated Briganti nomograms. This retrospective study included 1183 patients with localized PCa undergoing robot-assisted laparoscopic radical prostatectomy (RARP) combined with pelvic lymphadenectomy and 224 patients treated with sLND and external beam radiotherapy (EBRT), aiming to offer pelvic radiotherapy only in case of histologically positive SNs. In the RARP population, ePLND was applied in 956 (80.8%) patients,while 227 (19.2%) patients were offered ePLND combined with additional SNB. The median numbers of removed nodes were 10 (interquartile range, IQR = 6-14), 15 (IQR = 10-20) and 7 (IQR = 4-10) in the ePLND, ePLND + SNB, and sLND groups, respectively. Corresponding LNI rates were 16.6%, 25.5% and 42%. Based on the AUC, the performance of the Briganti nomogram (0.756) in the ePLND group was superior to both the MSKCC (0.744) and Winter nomogram (0.746). The Winter nomogram, however, was the best predictor of LNI in both the ePLND + SNB (0.735) and sLND (0.709) populations. In the calibration analysis, all nomograms showed better accuracy in the low/intermediate risk patients, while in the high-risk population, an overestimation of the risk for LNI was observed. The SN-based updated nomogram showed better prediction in the SN population. The results were also comparable, relative to predictive tools developed with (e)PLND, suggesting a difference in sampling accuracy between SNB and non-SNB. Patients who benefit most from the nomogram would be those with a low/intermediate risk of LN metastasis

Agreement analysis comparing iPad LCVA and Sloan testing in multiple sclerosis patients.

Science.gov (United States)

Sattarnezhad, Neda; Farrow, Samantha; Kimbrough, Dorlan; Glanz, Bonnie; Healy, Brian; Chitnis, Tanuja

2017-06-01

Visual symptoms are common in multiple sclerosis (MS). Low-contrast visual acuity (LCVA) testing using Sloan charts has demonstrated increased sensitivity for visual deficits compared to high-contrast acuity testing. Computerized testing of visual acuity may facilitate use in the clinic setting. To evaluate the agreement between an iPad-based and Sloan testing of LCVA in a cohort of MS patients. A total of 38 patients with relapsing-remitting MS were enrolled after providing informed written consent at Partners MS Center, Brigham and Women's hospital. Monocular LCVA was measured using retroilluminated Sloan chart and iPad-based LogMAR chart. Number of correct letters and agreement between two measurements were assessed for each eye using Bland-Altman analysis and paired t-test. For both eyes, there was no significant difference in number correct between the two measurements using a paired t-test, and there was high correlation between two measurements (oculus dextrus (OD) r = 0.89, p iPad-based LCVA test shows good agreement with Sloan testing in MS patients.

Customized broadband Sloan-filters for the JST/T250 and JAST/T80 telescopes: measurement summary

Science.gov (United States)

Brauneck, Ulf; Sprengard, Ruediger; Bourquin, Sebastien; Marín-Franch, Antonio

2018-01-01

The Centro de Estudios de Fisica del Cosmos de Aragon will conduct a photometric sky survey with two new telescopes recently set up on the Javalambre mountain in Spain: the JST/T250 is a 2.55-m telescope with a plate scale of 22.67 arc⁢sec/mm and a 3-deg-diameter field of view (FoV) and the auxiliary telescope JAST/T80 with a 82-cm primary mirror and an FoV of 2 deg diameter. A multiple CCD (9k-by-9k array size, 10-μm pixel size) mosaic camera is used in combination with filter trays or filter wheels, each containing a multitude of filters in dimensions of 101.7×96.5 mm or 106.8×106.8 mm. For this project, Schott manufactured 56 specially designed narrow band steep-edged bandpass interference filters and five broadband Sloan-filters which were completed only recently. We report here on the results of the broadband Sloan-filters with transmission bands of 324 to 400 nm (Sloan-u), 400 to 550 nm (Sloan-g), 550 to 700 nm (Sloan-r), 695 to 850 nm (Sloan-i), and 830 to 1200 nm (Sloan-z). The filters are composed of Schott filterglasses and clearglass substrates coated with interference filters and represent an improvement of broadband Sloan filters commonly used in astronomy. In spite of the absorptive elements, the filters show maximum possible transmissions achieved by magnetron sputtered filter coatings. In addition, the blocking of the filters is better than OD5 (transmission <10 to -5) in the range 250 to 1050 nm which was achieved by combining up to three substrates. A high image quality required a low transmitted wavefront error (<λ/8 locally, respectively <λ/2 globally). We report on the spectral and interferometric results measured on the filters.

Optimal needle arrangement for intraoperative planning in permanent I-125 prostate implants

International Nuclear Information System (INIS)

Thompson, S.A.; Fung, A.Y.C.; Zaider, M.

2002-01-01

One limitation of intraoperative planning of permanent prostate implants is that needles must already be in the gland before planning images are acquired. Improperly placed needles often restrict the capability of generating optimal seed placement. We developed guiding principles for the proper layout of needles within the treatment volume. The Memorial Sloan-Kettering Cancer Center planning system employs a genetic algorithm to find the optimal seed implantation pattern consistent with pre-assigned constraints (needle geometry, uniformity, conformity and the avoidance of high doses to urethra and rectum). Ultrasound volumes for twelve patients with I-125 implants were used to generate six plans per patient (total 72 plans) with different needle arrangements. The plans were evaluated in terms of V100 (percentage prostate volume receiving at least the prescription dose), U135 (percentage urethra volume receiving at least 135% of prescription dose), and CI (conformity index, the ratio of treatment volume to prescription dose volume.) The method termed POSTCTR, in which needles were placed on the periphery of the largest ultrasound slice and posterior central needles were placed as needed, consistently gave superior results for all prostate sizes. Another arrangement, labelled POSTLAT, where the needles were placed peripherally with additional needles in the posterior lateral lobes, also gave satisfactory results. We advocate two needle arrangements, POSTCTR and POSTLAT, with the former giving better results. (author)

NOTE: Optimal needle arrangement for intraoperative planning in permanent I-125 prostate implants

Science.gov (United States)

Thompson, S. A.; Fung, A. Y. C.; Zaider, M.

2002-08-01

One limitation of intraoperative planning of permanent prostate implants is that needles must already be in the gland before planning images are acquired. Improperly placed needles often restrict the capability of generating optimal seed placement. We developed guiding principles for the proper layout of needles within the treatment volume. The Memorial Sloan-Kettering Cancer Center planning system employs a genetic algorithm to find the optimal seed implantation pattern consistent with pre-assigned constraints (needle geometry, uniformity, conformity and the avoidance of high doses to urethra and rectum). Ultrasound volumes for twelve patients with I-125 implants were used to generate six plans per patient (total 72 plans) with different needle arrangements. The plans were evaluated in terms of V100 (percentage prostate volume receiving at least the prescription dose), U135 (percentage urethra volume receiving at least 135% of prescription dose), and CI (conformity index, the ratio of treatment volume to prescription dose volume.) The method termed POSTCTR, in which needles were placed on the periphery of the largest ultrasound slice and posterior central needles were placed as needed, consistently gave superior results for all prostate sizes. Another arrangement, labelled POSTLAT, where the needles were placed peripherally with additional needles in the posterior lateral lobes, also gave satisfactory results. We advocate two needle arrangements, POSTCTR and POSTLAT, with the former giving better results.

Optimal needle arrangement for intraoperative planning in permanent I-125 prostate implants

Energy Technology Data Exchange (ETDEWEB)

Thompson, S.A. [Department of Medical Physics, North Shore-Long Island Jewish Health System, Manhassett, NY (United States); Fung, A.Y.C.; Zaider, M. [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)

2002-08-21

One limitation of intraoperative planning of permanent prostate implants is that needles must already be in the gland before planning images are acquired. Improperly placed needles often restrict the capability of generating optimal seed placement. We developed guiding principles for the proper layout of needles within the treatment volume. The Memorial Sloan-Kettering Cancer Center planning system employs a genetic algorithm to find the optimal seed implantation pattern consistent with pre-assigned constraints (needle geometry, uniformity, conformity and the avoidance of high doses to urethra and rectum). Ultrasound volumes for twelve patients with I-125 implants were used to generate six plans per patient (total 72 plans) with different needle arrangements. The plans were evaluated in terms of V100 (percentage prostate volume receiving at least the prescription dose), U135 (percentage urethra volume receiving at least 135% of prescription dose), and CI (conformity index, the ratio of treatment volume to prescription dose volume.) The method termed POSTCTR, in which needles were placed on the periphery of the largest ultrasound slice and posterior central needles were placed as needed, consistently gave superior results for all prostate sizes. Another arrangement, labelled POSTLAT, where the needles were placed peripherally with additional needles in the posterior lateral lobes, also gave satisfactory results. We advocate two needle arrangements, POSTCTR and POSTLAT, with the former giving better results. (author)

Whole Blood mRNA Expression-Based Prognosis of Metastatic Renal Cell Carcinoma

Directory of Open Access Journals (Sweden)

Karthik V. Giridhar

2017-11-01

Full Text Available The Memorial Sloan Kettering Cancer Center (MSKCC prognostic score is based on clinical parameters. We analyzed whole blood mRNA expression in metastatic clear cell renal cell carcinoma (mCCRCC patients and compared it to the MSKCC score for predicting overall survival. In a discovery set of 19 patients with mRCC, we performed whole transcriptome RNA sequencing and selected eighteen candidate genes for further evaluation based on associations with overall survival and statistical significance. In an independent validation of set of 47 patients with mCCRCC, transcript expression of the 18 candidate genes were quantified using a customized NanoString probeset. Cox regression multivariate analysis confirmed that two of the candidate genes were significantly associated with overall survival. Higher expression of BAG1 [hazard ratio (HR of 0.14, p < 0.0001, 95% confidence interval (CI 0.04–0.36] and NOP56 (HR 0.13, p < 0.0001, 95% CI 0.05–0.34 were associated with better prognosis. A prognostic model incorporating expression of BAG1 and NOP56 into the MSKCC score improved prognostication significantly over a model using the MSKCC prognostic score only (p < 0.0001. Prognostic value of using whole blood mRNA gene profiling in mCCRCC is feasible and should be prospectively confirmed in larger studies.

Hemithoracic radiation therapy after pleurectomy/decortication for malignant pleural mesothelioma

International Nuclear Information System (INIS)

Gupta, Vishal; Mychalczak, Borys; Krug, Lee; Flores, Raja; Bains, Manjit; Rusch, Valerie W.; Rosenzweig, Kenneth E.

2005-01-01

Purpose: To evaluate pleurectomy/decortication (P/D) and adjuvant radiotherapy (RT) in the treatment of malignant pleural mesothelioma (MPM). Methods and Materials: In a retrospective review, we included MPM patients treated with P/D and adjuvant RT at Memorial Sloan-Kettering Cancer Center from 1974 to 2003. When indicated, patients received intraoperative brachytherapy to residual tumor. Results: All 123 patients received external beam RT (median dose, 42.5 Gy; range, 7.2-67.8 Gy) to the ipsilateral hemithorax postoperatively. Fifty-four patients underwent brachytherapy (matched peripheral dose, 160 Gy). The median and 2-year overall survival for all patients was 13.5 months (range, 1-199 months) and 23%, respectively. One-year actuarial local control for all patients was 42%. Multivariate analysis for overall survival revealed radiation dose <40 Gy (p = 0.001), nonepithelioid histology (p = 0.002), left-sided disease (p = 0.01), and the use of an implant (p = 0.02) to be unfavorable. Two patients (1.6%) died from Grade 5 toxicity within 1 month of treatment. Conclusions: Pleurectomy/decortication with adjuvant radiotherapy is not an effective treatment option for patients with MPM. Our results imply that residual disease cannot be eradicated with external RT with or without brachytherapy and that a more extensive surgery followed by external RT might be required to improve local control and overall survival

Learning and memory performance in a cohort of clinically referred breast cancer survivors: the role of attention versus forgetting in patient-reported memory complaints.

Science.gov (United States)

Root, James C; Ryan, Elizabeth; Barnett, Gregory; Andreotti, Charissa; Bolutayo, Kemi; Ahles, Tim

2015-05-01

While forgetfulness is widely reported by breast cancer survivors, studies documenting objective memory performance yield mixed, largely inconsistent, results. Failure to find consistent, objective memory issues may be due to the possibility that cancer survivors misattribute their experience of forgetfulness to primary memory issues rather than to difficulties in attention at the time of learning. To clarify potential attention issues, factor scores for Attention Span, Learning Efficiency, Delayed Memory, and Inaccurate Memory were analyzed for the California Verbal Learning Test-Second Edition (CVLT-II) in 64 clinically referred breast cancer survivors with self-reported cognitive complaints; item analysis was conducted to clarify specific contributors to observed effects, and contrasts between learning and recall trials were compared with normative data. Performance on broader cognitive domains is also reported. The Attention Span factor, but not Learning Efficiency, Delayed Memory, or Inaccurate Memory factors, was significantly affected in this clinical sample. Contrasts between trials were consistent with normative data and did not indicate greater loss of information over time than in the normative sample. Results of this analysis suggest that attentional dysfunction may contribute to subjective and objective memory complaints in breast cancer survivors. These results are discussed in the context of broader cognitive effects following treatment for clinicians who may see cancer survivors for assessment. Copyright © 2014 John Wiley & Sons, Ltd.

Analysis of biopsy outcome after three-dimensional conformal radiation therapy of prostate cancer using dose-distribution variables and tumor control probability models

International Nuclear Information System (INIS)

Levegruen, Sabine; Jackson, Andrew; Zelefsky, Michael J.; Venkatraman, Ennapadam S.; Skwarchuk, Mark W.; Schlegel, Wolfgang; Fuks, Zvi; Leibel, Steven A.; Ling, C. Clifton

2000-01-01

Purpose: To investigate tumor control following three-dimensional conformal radiation therapy (3D-CRT) of prostate cancer and to identify dose-distribution variables that correlate with local control assessed through posttreatment prostate biopsies. Methods and Material: Data from 132 patients, treated at Memorial Sloan-Kettering Cancer Center (MSKCC), who had a prostate biopsy 2.5 years or more after 3D-CRT for T1c-T3 prostate cancer with prescription doses of 64.8-81 Gy were analyzed. Variables derived from the dose distribution in the PTV included: minimum dose (Dmin), maximum dose (Dmax), mean dose (Dmean), dose to n% of the PTV (Dn), where n = 1%, ..., 99%. The concept of the equivalent uniform dose (EUD) was evaluated for different values of the surviving fraction at 2 Gy (SF 2 ). Four tumor control probability (TCP) models (one phenomenologic model using a logistic function and three Poisson cell kill models) were investigated using two sets of input parameters, one for low and one for high T-stage tumors. Application of both sets to all patients was also investigated. In addition, several tumor-related prognostic variables were examined (including T-stage, Gleason score). Univariate and multivariate logistic regression analyses were performed. The ability of the logistic regression models (univariate and multivariate) to predict the biopsy result correctly was tested by performing cross-validation analyses and evaluating the results in terms of receiver operating characteristic (ROC) curves. Results: In univariate analysis, prescription dose (Dprescr), Dmax, Dmean, dose to n% of the PTV with n of 70% or less correlate with outcome (p 2 : EUD correlates significantly with outcome for SF 2 of 0.4 or more, but not for lower SF 2 values. Using either of the two input parameters sets, all TCP models correlate with outcome (p 2 , is limited because the low dose region may not coincide with the tumor location. Instead, for MSKCC prostate cancer patients with their

Report on the Clinical Outcomes of Permanent Breast Seed Implant for Early-Stage Breast Cancers

International Nuclear Information System (INIS)

Pignol, Jean-Philippe; Caudrelier, Jean-Michel; Crook, Juanita; McCann, Claire; Truong, Pauline; Verkooijen, Helena A.

2015-01-01

Purpose: Permanent breast seed implant is an accelerated partial breast irradiation technique realizing the insertion of "1"0"3Pd seeds in the seroma after lumpectomy. We report the 5-year efficacy and tolerance for a cohort, pooling patients from 3 clinical trials. Methods and Materials: The trials accrued postmenopausal patients with infiltrating ductal carcinoma or ductal carcinoma in situ ≤3 cm and clear surgical margins, who were node negative, and had a planning target volume <120 cm"3. The outcomes included overall and disease-free survival and local and contralateral recurrence at 5 years. The true local recurrence rate was compared using 2-tailed paired t tests for estimates calculated using the Tufts University ipsilateral breast tumor recurrence and Memorial Sloan Kettering ductal carcinoma in situ nomograms. Results: The cohort included 134 patients, and the observed local recurrence rate at a median follow-up period of 63 months was 1.2% ± 1.2%, similar to the estimate for whole breast irradiation (P=.23), significantly better than for surgery alone (relative risk 0.27; P<.001), and significantly lower than contralateral recurrence (relative risk 0.33; P<.001). The 5-year overall survival rate was 97.4% ± 1.9%, and the disease-free survival rate was 96.4% ± 2.1%. At 2 months, 42% of the patients had erythema, 20% induration, and 16% moist desquamation. The rate of mainly grade 1 telangiectasia was 22.4% at 2 years and 24% at 5 years. The rate of asymptomatic induration was 23% at 2 years and 40% at 5 years. Conclusions: The 5-year data suggest that permanent breast seed implantation is a safe accelerated partial breast irradiation option after lumpectomy for early-stage breast cancer with a tolerance profile similar to that of whole breast irradiation.

Report on the Clinical Outcomes of Permanent Breast Seed Implant for Early-Stage Breast Cancers

Energy Technology Data Exchange (ETDEWEB)

Pignol, Jean-Philippe, E-mail: j.p.pignol@erasmusmc.nl [Radiation Oncology Department, University of Toronto at Sunnybrook Health Sciences Centre, Toronto, Ontario (Canada); Radiation Oncology Department, Erasmus Medical Center Cancer Institute, Rotterdam (Netherlands); Caudrelier, Jean-Michel [Department of Radiation Medicine, The Ottawa Hospital Cancer Centre, Ottawa, Ontario (Canada); Crook, Juanita [Department of Radiation Oncology, BC Cancer Agency Center for the Southern Interior, Kelowna, British Columbia (Canada); McCann, Claire [Radiation Oncology Department, University of Toronto at Sunnybrook Health Sciences Centre, Toronto, Ontario (Canada); Truong, Pauline [Radiation Oncology Department, BC Cancer Agency Vancouver Island Centre, Victoria, British Columbia (Canada); Verkooijen, Helena A. [Imaging Division, University Medical Centre Utrecht, Utrecht (Netherlands)

2015-11-01

Purpose: Permanent breast seed implant is an accelerated partial breast irradiation technique realizing the insertion of {sup 103}Pd seeds in the seroma after lumpectomy. We report the 5-year efficacy and tolerance for a cohort, pooling patients from 3 clinical trials. Methods and Materials: The trials accrued postmenopausal patients with infiltrating ductal carcinoma or ductal carcinoma in situ ≤3 cm and clear surgical margins, who were node negative, and had a planning target volume <120 cm{sup 3}. The outcomes included overall and disease-free survival and local and contralateral recurrence at 5 years. The true local recurrence rate was compared using 2-tailed paired t tests for estimates calculated using the Tufts University ipsilateral breast tumor recurrence and Memorial Sloan Kettering ductal carcinoma in situ nomograms. Results: The cohort included 134 patients, and the observed local recurrence rate at a median follow-up period of 63 months was 1.2% ± 1.2%, similar to the estimate for whole breast irradiation (P=.23), significantly better than for surgery alone (relative risk 0.27; P<.001), and significantly lower than contralateral recurrence (relative risk 0.33; P<.001). The 5-year overall survival rate was 97.4% ± 1.9%, and the disease-free survival rate was 96.4% ± 2.1%. At 2 months, 42% of the patients had erythema, 20% induration, and 16% moist desquamation. The rate of mainly grade 1 telangiectasia was 22.4% at 2 years and 24% at 5 years. The rate of asymptomatic induration was 23% at 2 years and 40% at 5 years. Conclusions: The 5-year data suggest that permanent breast seed implantation is a safe accelerated partial breast irradiation option after lumpectomy for early-stage breast cancer with a tolerance profile similar to that of whole breast irradiation.

Reverse Stage Shift at a Tertiary Care Center: Escalating Risk in Men Undergoing Radical Prostatectomy

Science.gov (United States)

Silberstein, Jonathan L.; Vickers, Andrew J.; Power, Nicholas E.; Fine, Samson W.; Scardino, Peter T.; Eastham, James A.; Laudone, Vincent P.

2011-01-01

Purpose To evaluate changes in clinical and pathological characteristics of prostate cancer in patients treated surgically at a large tertiary care center in the context of increased use of active surveillance (AS) and minimally invasive surgery (MIS). Materials We performed retrospective review of 6,624 patients with localized prostate cancer who underwent radical prostatectomy from 2000–2010 at Memorial Sloan-Kettering Cancer Center. Patients were stratified by surgical approach (open, laparoscopic or robotic) and risk categories (low, intermediate, or high). Patients with low-risk disease, without intervention and minimum followup of 6 months were considered to have elected AS. Results AS cases increased from <20 per year between 2000–2004 to ≥100 per year between 2007–2009. Over the same decade MIS cases (laparoscopic or robotic) increased from zero to 63% of all surgical cases. The percentage of patients in intermediate- and high-risk categories increased over time, while the percentage in the low-risk category decreased (OR per year 0.91, 95% CI 0.89, 0.92, p <0.0005). The proportion of surgery patients with Gleason 6 tumors decreased over time (OR per year 0.87, 95% CI 0.85, 0.88; p <0.0005) while pathologic stage and Gleason score increased (p <0.0005). The proportion of low-risk cases decreased across all types of surgery, with the largest decrease in robotic surgery (p <0.0005). Conclusions We observed a reverse stage shift in patients undergoing radical prostatectomy since 2000 despite the introduction and rapid proliferation of MIS. These findings may be due to increased use of AS and institutional focus on treatment of higher-risk disease. PMID:21484780

Maximal safe dose therapy of I-131 after failure of standard fixed dose therapy in patients with differentiated thyroid carcinoma

International Nuclear Information System (INIS)

Lee, Jong Jin; Seok, Ju Won; Uh, Jae Sun

2005-01-01

In patients with recurrent or metastatic differentiated thyroid carcinoma, residual disease despite repetitive fixed dose I-131 therapy presents an awkward situation in terms of treatment decision making. Maximal safe dose (MSD) administration base on bone marrow radiation allows the delivery of a large amount I-131 to thyroid cancer tissue within the safety margin. We investigated the efficacy of MSD in differentiated thyroid cancers, which had persisted after conventional fixed dose therapy. Forty-six patients with differentiated thyroid carcinoma who had non-responsible residual disease despite repetitive fixed dose I-131 therapy were enrolled in this study. The postoperative pathology consisted of 43 papillary carcinomas and 3 follicular carcinomas. MSD was calculated according the Memorial Sloan Kettering Cancer Center protocol using blood samples. MSDs were administered at intervals of at least 6 months. Treatment responses were evaluated using I-131 whole body scan (WBS) and serum thyroglobulin measurements. Mean calculated MSD was 12.5±2.1 GBq. Of the 46 patients, 6 (13.0%) showed complete remission, 15 (32.6%) partial response, 19 (41.3%) stable disease, and 6 (13.0%) disease progression. Thus, about a half of the patients showed complete or partial remission, and of these patients, 14 (67%) showed response after a single MSD administration and 6 (29%) showed response after the second dose of MSD administrations. Twenty-nine patients (63%) experienced transient cytopenia after therapy, and recovered spontaneously with the exception of one. MSD administration is an effective method even in the patients who failed to be treated by conventional fixed dose therapy. MSD therapy of I-131 can be considered in the patients who failed by fixed dose therapy

Risk group dependence of dose-response for biopsy outcome after three-dimensional conformal radiation therapy of prostate cancer

International Nuclear Information System (INIS)

Levegruen, Sabine; Jackson, Andrew; Zelefsky, Michael J.; Venkatraman, Ennapadam S.; Skwarchuk, Mark W.; Schlegel, Wolfgang; Fuks, Zvi; Leibel, Steven A.; Ling, C. Clifton

2002-01-01

Background and purpose: We fit phenomenological tumor control probability (TCP) models to biopsy outcome after three-dimensional conformal radiation therapy (3D-CRT) of prostate cancer patients to quantify the local dose-response of prostate cancer. Materials and methods: We analyzed the outcome after photon beam 3D-CRT of 103 patients with stage T1c-T3 prostate cancer treated at Memorial Sloan-Kettering Cancer Center (MSKCC) (prescribed target doses between 64.8 and 81 Gy) who had a prostate biopsy performed ≥2.5 years after end of treatment. A univariate logistic regression model based on D mean (mean dose in the planning target volume of each patient) was fit to the whole data set and separately to subgroups characterized by low and high values of tumor-related prognostic factors T-stage ( 6), and pre-treatment prostate-specific antigen (PSA) (≤10 ng/ml vs. >10 ng/ml). In addition, we evaluated five different classifications of the patients into three risk groups, based on all possible combinations of two or three prognostic factors, and fit bivariate logistic regression models with D mean and the risk group category to all patients. Dose-response curves were characterized by TCD 50 , the dose to control 50% of the tumors, and γ 50 , the normalized slope of the dose-response curve at TCD 50 . Results: D mean correlates significantly with biopsy outcome in all patient subgroups and larger values of TCD 50 are observed for patients with unfavorable compared to favorable prognostic factors. For example, TCD 50 for high T-stage patients is 7 Gy higher than for low T-stage patients. For all evaluated risk group definitions, D mean and the risk group category are independent predictors of biopsy outcome in bivariate analysis. The fit values of TCD 50 show a clear separation of 9-10.6 Gy between low and high risk patients. The corresponding dose-response curves are steeper (γ 50 =3.4-5.2) than those obtained when all patients are analyzed together (γ 50 =2

Medicinal use of earths and minerals from Hippocrates to Sir Hans Sloane and beyond.

Science.gov (United States)

Retsas, Spyros

2012-12-01

In 1931 two pharmaceutical drawers containing mineral specimens, belonging to Sir Hans Sloane, the 18th century collector, Royal Physician, President of the Royal Society and of the Royal College of Physicians of London, were found in the Department of Botany of the Natural History Museum (NHM) of London. The drawers, each divided into 49 compartments, contained a total of 107 mineral pharmaceutical specimens, some labelled as mercury or white arsenic. Their registration, identification with the Sloane Manuscript Catalogues and subsequent transfer to the Mineralogy department of the NHM where one of these drawers is now on public display, had been documented by 1935. In antiquity therapeutic empiricism attributed medicinal properties to animal products, plants and minerals, including the soil of specific geographic locations. This communication traces the medicinal use of certain earths and minerals, listed in Sir Hans Sloane's manuscript catalogues, to classical antiquity with a reference to Arsenic compounds, which in our time are finding application in the treatment of acute promyelocytic leukaemia and to Terra Lemnia, a celebrated antidote of repute spanning twenty centuries, also included in the Sloane collections.

Adjuvant therapy after resection of colorectal liver metastases: the predictive value of the MSKCC clinical risk score in the era of modern chemotherapy.

Science.gov (United States)

Rahbari, Nuh N; Reissfelder, Christoph; Schulze-Bergkamen, Henning; Jäger, Dirk; Büchler, Markus W; Weitz, Jürgen; Koch, Moritz

2014-03-11

Despite introduction of effective chemotherapy protocols, it has remained uncertain, if patients with colorectal cancer (CRC) liver metastases should receive adjuvant therapy. Clinical or molecular predictors may help to select patients at high risk for disease recurrence and death who obtain a survival advantage by adjuvant chemotherapy. A total of 297 patients with potentially curative resection of CRC liver metastases were analyzed. These patients had no neoadjuvant therapy, no extrahepatic disease and negative resection margins. The primary endpoint was overall survival. Patients' risk status was evaluated using the Memorial Sloan-Kettering Cancer Center clinical risk score (MSKCC-CRS). Multivariable analyses were performed using Cox proportional hazard models. A total of 137 (43%) patients had a MSKCC-CRS > 2. Adjuvant chemotherapy was administered to 116 (37%) patients. Patients who received adjuvant chemotherapy were of younger age (p = 0.03) with no significant difference in the presence of multiple metastases (p = 0.72) or bilobar metastases (p = 0.08). On multivariate analysis adjuvant chemotherapy was associated with improved survival in the entire cohort (Hazard ratio 0.69; 95% confidence interval 0.69-0.98). It improved survival markedly in high-risk patients with a MSKCC-CRS > 2 (HR 0.40; 95% CI 0.23-0.69), whereas it was of no benefit in patients with a MSKCC-CRS ≤ 2 (HR 0.90; 95% CI 0.57-1.43). The MSKCC-CRS offers a tool to select patients for adjuvant therapy after resection of CRC liver metastases. Validation in independent patient cohorts is required.

New models and online calculator for predicting non-sentinel lymph node status in sentinel lymph node positive breast cancer patients

Directory of Open Access Journals (Sweden)

Johnson Denise L

2008-03-01

Full Text Available Abstract Background Current practice is to perform a completion axillary lymph node dissection (ALND for breast cancer patients with tumor-involved sentinel lymph nodes (SLNs, although fewer than half will have non-sentinel node (NSLN metastasis. Our goal was to develop new models to quantify the risk of NSLN metastasis in SLN-positive patients and to compare predictive capabilities to another widely used model. Methods We constructed three models to predict NSLN status: recursive partitioning with receiver operating characteristic curves (RP-ROC, boosted Classification and Regression Trees (CART, and multivariate logistic regression (MLR informed by CART. Data were compiled from a multicenter Northern California and Oregon database of 784 patients who prospectively underwent SLN biopsy and completion ALND. We compared the predictive abilities of our best model and the Memorial Sloan-Kettering Breast Cancer Nomogram (Nomogram in our dataset and an independent dataset from Northwestern University. Results 285 patients had positive SLNs, of which 213 had known angiolymphatic invasion status and 171 had complete pathologic data including hormone receptor status. 264 (93% patients had limited SLN disease (micrometastasis, 70%, or isolated tumor cells, 23%. 101 (35% of all SLN-positive patients had tumor-involved NSLNs. Three variables (tumor size, angiolymphatic invasion, and SLN metastasis size predicted risk in all our models. RP-ROC and boosted CART stratified patients into four risk levels. MLR informed by CART was most accurate. Using two composite predictors calculated from three variables, MLR informed by CART was more accurate than the Nomogram computed using eight predictors. In our dataset, area under ROC curve (AUC was 0.83/0.85 for MLR (n = 213/n = 171 and 0.77 for Nomogram (n = 171. When applied to an independent dataset (n = 77, AUC was 0.74 for our model and 0.62 for Nomogram. The composite predictors in our model were the product of

Induction chemotherapy plus three-dimensional conformal radiation therapy in the definitive treatment of locally advanced non-small-cell lung cancer

International Nuclear Information System (INIS)

Sim, Sang; Rosenzweig, Kenneth E.; Schindelheim, Rachel; Ng, Kenneth K.; Leibel, Steven A.

2001-01-01

Purpose: To evaluate our institution's experience using chemotherapy in conjunction with three-dimensional conformal radiation therapy (3D-CRT). Methods and Materials: From 1991 to 1998, 152 patients with Stage III non-small-cell lung cancer (NSCLC) were treated with 3D-CRT at Memorial Sloan-Kettering Cancer Center. A total of 137 patients (90%) were surgically staged with either thoracotomy or mediastinoscopy. The remainder were staged radiographically. Seventy patients were treated with radiation therapy alone, and 82 patients received induction chemotherapy before radiation. The majority of chemotherapy-treated patients received a platinum-containing regimen. Radiation was delivered with a 3D conformal technique using CT-based treatment planning. The median dose in the radiation alone group was 70.2 Gy, while in the combined modality group, it was 64.8 Gy. Results: The median follow-up time was 30.5 months among survivors. Stage IIIB disease was present in 36 patients (51%) in the radiation-alone group and 57 patients (70%) in the combined-modality group. Thirty-nine patients had poor prognostic factors (KPS 5%), and they were equally distributed between the two groups. The median survival times for the radiation-alone and the combined-modality groups were 11.7 months and 18.1 months, respectively (p=0.001). The 2-year rates of local control in the radiation-alone and combined-modality groups were 35.4% and 43.1%, respectively (p=0.1). Grade 3 or worse nonhematologic toxicity occurred in 20% of the patients receiving radiation alone and in 16% of those receiving chemotherapy and radiation. Overall, there were only 4 cases of Grade 3 or worse esophagitis. Conclusion: Despite more Stage IIIB patients in the combined-modality group, the addition of chemotherapy to 3D-CRT produced a survival advantage over 3D-CRT alone in Stage III NSCLC without a concomitant increase in toxicity. Chemotherapy thus appears to be beneficial, even in patients who are receiving higher

Robert R. Shaw, MD: thoracic surgical hero, Afghanistan medical pioneer, champion for the patient, never a surgical society president.

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Urschel, Harold C; Urschel, Betsey Bradley

2012-06-01

Dr Robert R. Shaw arrived in Dallas to practice Thoracic Surgery in 1937, as John Alexander's 7th Thoracic Surgical Resident from Michigan University Medical Center. Dr Shaw's modus operandi was, "You can accomplish almost anything, if you don't care who gets the credit." He was a remarkable individual who cared the most about the patient and very little about getting credit for himself. From 1937 to 1970, Dr Shaw established one of the largest lung cancer surgical centers in the world in Dallas, Texas. It was larger than M.D. Anderson and Memorial Sloan-Kettering Hospitals put together regarding the surgical treatment of lung cancer patients. To accomplish this, he had the help of Dr Donald L. Paulson, who trained at the Mayo Clinic and served as Chief of Thoracic Surgery at Brook Army Hospital during the Second World War. Following the War, because of his love for Texas, he ended up as a partner of Dr Shaw in Dallas. Together, they pursued the development of this very large surgical lung cancer center. Dr Shaw and his wife Ruth went to Afghanistan with Medico multiple times to teach men modern cardiac and thoracic surgery. They also served as consultants on Medico's Ship of Hope in Africa. Dr Shaw initiated multiple new operations including: 1) resection of Pancoast's cancer of the lung after preoperative irradiation; 2) upper lobe of the lung bronchoplasty, reattaching (and saving) the lower lobe to prevent the "disabling" pneumonectomy; and 3) resections of pulmonary mucoid impaction of the lung in asthmatics. Because of his humility and giving "the credit to others," Dr Shaw was never President of a major medical or surgical association. Copyright © 2012 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

Prognostic impact of the pretreatment aspartate transaminase/alanine transaminase ratio in patients treated with first-line systemic tyrosine kinase inhibitor therapy for metastatic renal cell carcinoma.

Science.gov (United States)

Kang, Minyong; Yu, Jiwoong; Sung, Hyun Hwan; Jeon, Hwang Gyun; Jeong, Byong Chang; Park, Se Hoon; Jeon, Seong Soo; Lee, Hyun Moo; Choi, Han Yong; Seo, Seong Il

2018-05-13

To examine the prognostic role of the pretreatment aspartate transaminase/alanine transaminase or De Ritis ratio in patients with metastatic renal cell carcinoma receiving first-line systemic tyrosine kinase inhibitor therapy. We retrospectively searched the medical records of 579 patients with metastatic renal cell carcinoma who visited Samsung Medical Center, Seoul, Korea, from January 2001 through August 2016. After excluding 210 patients, we analyzed 360 patients who received first-line tyrosine kinase inhibitor therapy. Cancer-specific survival and overall survival were defined as the primary and secondary end-points, respectively. A multivariate Cox proportional hazards regression model was used to identify independent prognosticators of survival outcomes. The overall population was divided into two groups according to the pretreatment De Ritis ratio as an optimal cut-off value of 1.2, which was determined by a time-dependent receiver operating characteristic curve analysis. Patients with a higher pretreatment De Ritis ratio (≥1.2) had worse cancer-specific survival and overall survival outcomes, compared with those with a lower De Ritis ratio (<1.2). Notably, a higher De Ritis ratio (≥1.2) was found to be an independent predictor of both cancer-specific survival (hazard ratio 1.61, 95% confidence interval 1.13-2.30) and overall survival outcomes (hazard ratio 1.69, 95% confidence interval 1.19-2.39), along with male sex, multiple metastasis (≥2), non-clear cell histology, advanced pT stage (≥3), previous metastasectomy and the Memorial Sloan Kettering Cancer Center risk classification. Our findings show that the pretreatment De Ritis ratio can provide valuable information about the survival outcomes of metastatic renal cell carcinoma patients receiving first-line tyrosine kinase inhibitor therapy. © 2018 The Japanese Urological Association.

TU-F-12A-01: Quantitative Non-Linear Compartment Modeling of 89Zr- and 124I- Labeled J591 Monoclonal Antibody Kinetics Using Serial Non-Invasive Positron Emission Tomography Imaging in a Pre-Clinical Human Prostate Cancer Mouse Model

Energy Technology Data Exchange (ETDEWEB)

Fung, EK; Cheal, SM; Chalasani, S; Fareedy, SB; Punzalan, B; Humm, JL; Osborne, JR; Larson, SM; Zanzonico, PB [Memorial Sloan Kettering Cancer Center, New York, NY (United States); Otto, B; Bander, NH [Weill Cornell Medical College, New York, NY (United States)

2014-06-15

-drug conjugates. Further exploration using the model will examine binding and radioisotope residence as antibody dose is increased to antigen saturation. The Center for Targeted Radioimmunotherapy and Theranostics, Ludwig Center for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center (MSK), NIH (R25-CA096945). Technical services provided by the MSK Small-Animal Imaging Core Facility were supported by the NIH (R24-CA83084, P30-CA08748, and P50-CA92629; Zanzonico). NCI, Center to Reduce Cancer Health Disparity (R21 CA153177-03; Osborne)

Customized broadband sloan-filters for the JST/T250 and JAST/T80 telescopes: summary of results

Science.gov (United States)

Brauneck, U.; Sprengard, R.; Bourquin, S.; Marín-Franch, A.

2017-09-01

The Centro de Estudios de Fisica del Cosmos de Aragon (CEFCA) will conduct a photometric sky survey with 2 new telescopes recently setup on the Javalambre mountain in Spain: the JST/T250 is a 2.55m telescope with a plate scale of 22.67"/mm and a 3° diameter field of view (FoV) and the auxiliary telescope JAST/T80 with a 82cm primary mirror and a FoV of 2 deg diameter. A multiple CCD (9k-by-9k array size, 10μm pixel size) mosaic camera is used in combination with filter trays or filter wheels, each containing a multitude of filters in dimensions of 101.7x96.5mm or 106.8x106.8mm. For this project, SCHOTT manufactured 56 specially designed narrow band steep edged bandpass interference filters and 5 broadband sloan-filters which were completed only recently. We report here on the results of the broadband sloanfilters with transmission bands of 324-400nm (sloan-u), 400-550nm (sloan-g), 550-700nm (sloan-r), 695-850nm (sloan-i) and 830-1200nm (sloan-z). The filters are composed of SCHOTT filterglasses and clearglass substrates coated with interference filters and represent an improvement of broadband sloan filters commonly used in astronomy. Inspite of the absorptive elements, the filters show maximum possible transmissions achieved by magnetron sputtered filter coatings. In addition the blocking of the filters is better than OD5 in the range 250-1050nm. A high image quality required a low transmitted wavefront error (<λ/8 locally, respectively <λ/2 globally) which was achieved by combining up to 2 substrates. We report on the spectral and interferometric results measured on the filters.

The sloan digital sky survey-II supernova survey

DEFF Research Database (Denmark)

Frieman, Joshua A.; Bassett, Bruce; Becker, Andrew

2008-01-01

The Sloan Digital Sky Survey-II (SDSS-II) has embarked on a multi-year project to identify and measure light curves for intermediate-redshift (0.05 < z < 0.35) Type Ia supernovae (SNe Ia) using repeated five-band (ugriz) imaging over an area of 300 sq. deg. The survey region is a stripe 2.5° wide...

Overcoming intratumoural heterogeneity for reproducible molecular risk stratification: a case study in advanced kidney cancer.

Science.gov (United States)

Lubbock, Alexander L R; Stewart, Grant D; O'Mahony, Fiach C; Laird, Alexander; Mullen, Peter; O'Donnell, Marie; Powles, Thomas; Harrison, David J; Overton, Ian M

2017-06-26

Metastatic clear cell renal cell cancer (mccRCC) portends a poor prognosis and urgently requires better clinical tools for prognostication as well as for prediction of response to treatment. Considerable investment in molecular risk stratification has sought to overcome the performance ceiling encountered by methods restricted to traditional clinical parameters. However, replication of results has proven challenging, and intratumoural heterogeneity (ITH) may confound attempts at tissue-based stratification. We investigated the influence of confounding ITH on the performance of a novel molecular prognostic model, enabled by pathologist-guided multiregion sampling (n = 183) of geographically separated mccRCC cohorts from the SuMR trial (development, n = 22) and the SCOTRRCC study (validation, n = 22). Tumour protein levels quantified by reverse phase protein array (RPPA) were investigated alongside clinical variables. Regularised wrapper selection identified features for Cox multivariate analysis with overall survival as the primary endpoint. The optimal subset of variables in the final stratification model consisted of N-cadherin, EPCAM, Age, mTOR (NEAT). Risk groups from NEAT had a markedly different prognosis in the validation cohort (log-rank p = 7.62 × 10 -7 ; hazard ratio (HR) 37.9, 95% confidence interval 4.1-353.8) and 2-year survival rates (accuracy = 82%, Matthews correlation coefficient = 0.62). Comparisons with established clinico-pathological scores suggest favourable performance for NEAT (Net reclassification improvement 7.1% vs International Metastatic Database Consortium score, 25.4% vs Memorial Sloan Kettering Cancer Center score). Limitations include the relatively small cohorts and associated wide confidence intervals on predictive performance. Our multiregion sampling approach enabled investigation of NEAT validation when limiting the number of samples analysed per tumour, which significantly degraded performance

The Sloan Lens ACS Survey. I. A large spectroscopically selected sample of massive early-type lens galaxies

NARCIS (Netherlands)

Bolton, AS; Burles, S; Koopmans, LVE; Treu, T; Moustakas, LA

2006-01-01

The Sloan Lens ACS (SLACS) Survey is an efficient Hubble Space Telescope (HST) Snapshot imaging survey for new galaxy-scale strong gravitational lenses. The targeted lens candidates are selected spectroscopically from the Sloan Digital Sky Survey (SDSS) database of galaxy spectra for having multiple

Self-reported memory problems in adult-onset cancer survivors: effects of cardiovascular disease and insomnia.

Science.gov (United States)

Jean-Pierre, Pascal; Grandner, Michael A; Garland, Sheila N; Henry, Elizabeth; Jean-Louis, Girardin; Burish, Thomas G

2015-07-01

Cancer and its treatments can deleteriously affect memory. Cardiac function and insomnia can exacerbate memory problems. To examine the relationships among cardiovascular disease, insomnia, and self-reported memory problems (SRMP) in adult-onset cancer survivors. We included data from participants (41-64 year-old) of the 2007-2008 National Health and Nutrition Examination Survey, a nationally representative probability sample of the civilian, non-institutionalized population of the US. We excluded participants with brain cancer/stroke history since these conditions are expected to cause cognitive problems. Using binary logistic regression, we determined the prevalence of SRMP relative to cardiac problems and insomnia by weighting our results proportionally. We adjusted for predictors of memory problems: age, sex, race, education and general health. The sample included 2289 adults (49% females), 9% with a cancer history. The results pertain only to cancer survivors. Those with insomnia were 16 times as likely to have SRMP. Only insomnia symptoms (OR, 15.74; 95% CI, 1.73-143.30; p Insomnia accounted for 18.8% of the association between cardiac issues and SRMP, demonstrating mediation (Sobel p insomnia were not associated with SRMP (p > 0.05). We could not determine severity and time-related changes in SRMP. Likelihood of SRMP was higher in cancer survivors with a history of cardiovascular disease and insomnia symptoms. Future studies are needed to delineate the cardiac-insomnia-memory interrelationships. Copyright © 2015 Elsevier B.V. All rights reserved.

Communication skills training: describing a new conceptual model.

Science.gov (United States)

Brown, Richard F; Bylund, Carma L

2008-01-01

Current research in communication in physician-patient consultations is multidisciplinary and multimethodological. As this research has progressed, a considerable body of evidence on the best practices in physician-patient communication has been amassed. This evidence provides a foundation for communication skills training (CST) at all levels of medical education. Although the CST literature has demonstrated that communication skills can be taught, one critique of this literature is that it is not always clear which skills are being taught and whether those skills are matched with those being assessed. The Memorial Sloan-Kettering Cancer Center Comskil Model for CST seeks to answer those critiques by explicitly defining the important components of a consultation, based on Goals, Plans, and Actions theories and sociolinguistic theory. Sequenced guidelines as a mechanism for teaching about particular communication challenges are adapted from these other methods. The authors propose that consultation communication can be guided by an overarching goal, which is achieved through the use of a set of predetermined strategies. Strategies are common in CST; however, strategies often contain embedded communication skills. These skills can exist across strategies, and the Comskil Model seeks to make them explicit in these contexts. Separate from the skills are process tasks and cognitive appraisals that need to be addressed in teaching. The authors also describe how assessment practices foster concordance between skills taught and those assessed through careful coding of trainees' communication encounters and direct feedback.

Adult Rhabdomyosarcoma Survival Improved With Treatment on Multimodality Protocols

International Nuclear Information System (INIS)

Gerber, Naamit Kurshan; Wexler, Leonard H.; Singer, Samuel; Alektiar, Kaled M.; Keohan, Mary Louise; Shi, Weiji; Zhang, Zhigang; Wolden, Suzanne

2013-01-01

Purpose: Rhabdomyosarcoma (RMS) is a pediatric sarcoma rarely occurring in adults. For unknown reasons, adults with RMS have worse outcomes than do children. Methods and Materials: We analyzed data from all patients who presented to Memorial Sloan-Kettering Cancer Center between 1990 and 2011 with RMS diagnosed at age 16 or older. One hundred forty-eight patients met the study criteria. Ten were excluded for lack of adequate data. Results: The median age was 28 years. The histologic diagnoses were as follows: embryonal 54%, alveolar 33%, pleomorphic 12%, and not otherwise specified 2%. The tumor site was unfavorable in 67% of patients. Thirty-three patients (24%) were at low risk, 61 (44%) at intermediate risk, and 44 (32%) at high risk. Forty-six percent were treated on or according to a prospective RMS protocol. The 5-year rate of overall survival (OS) was 45% for patients with nonmetastatic disease. The failure rates at 5 years for patients with nonmetastatic disease were 34% for local failure and 42% for distant failure. Among patients with nonmetastatic disease (n=94), significant factors associated with OS were histologic diagnosis, site, risk group, age, and protocol treatment. On multivariate analysis, risk group and protocol treatment were significant after adjustment for age. The 5-year OS was 54% for protocol patients versus 36% for nonprotocol patients. Conclusions: Survival in adult patients with nonmetastatic disease was significantly improved for those treated on RMS protocols, most of which are now open to adults

CheckMate 025 Randomized Phase 3 Study: Outcomes by Key Baseline Factors and Prior Therapy for Nivolumab Versus Everolimus in Advanced Renal Cell Carcinoma.

Science.gov (United States)

Escudier, Bernard; Sharma, Padmanee; McDermott, David F; George, Saby; Hammers, Hans J; Srinivas, Sandhya; Tykodi, Scott S; Sosman, Jeffrey A; Procopio, Giuseppe; Plimack, Elizabeth R; Castellano, Daniel; Gurney, Howard; Donskov, Frede; Peltola, Katriina; Wagstaff, John; Gauler, Thomas C; Ueda, Takeshi; Zhao, Huanyu; Waxman, Ian M; Motzer, Robert J

2017-12-01

The randomized, phase 3 CheckMate 025 study of nivolumab (n=410) versus everolimus (n=411) in previously treated adults (75% male; 88% white) with advanced renal cell carcinoma (aRCC) demonstrated significantly improved overall survival (OS) and objective response rate (ORR). To investigate which baseline factors were associated with OS and ORR benefit with nivolumab versus everolimus. Subgroup OS analyses were performed using Kaplan-Meier methodology. Hazard ratios were estimated using the Cox proportional hazards model. Nivolumab 3mg/kg every 2 wk or everolimus 10mg once daily. The minimum follow-up was 14 mo. Baseline subgroup distributions were balanced between nivolumab and everolimus arms. Nivolumab demonstrated an OS improvement versus everolimus across subgroups, including Memorial Sloan Kettering Cancer Center (MSKCC) and International Metastatic Renal Cell Carcinoma Database Consortium risk groups; age guide treatment decisions, and further supports nivolumab as the standard of care in previously treated patients with aRCC. We investigated the impact of demographic and pretreatment features on survival benefit and tumor response with nivolumab versus everolimus in advanced renal cell carcinoma (aRCC). Survival benefit and response were observed for multiple subgroups, supporting the use of nivolumab as a new standard of care across a broad range of patients with previously treated aRCC. The trial is registered on ClinicalTrials.gov as NCT01668784. Copyright © 2017 European Association of Urology. Published by Elsevier B.V. All rights reserved.

Variability in Predictions from Online Tools: A Demonstration Using Internet-Based Melanoma Predictors.

Science.gov (United States)

Zabor, Emily C; Coit, Daniel; Gershenwald, Jeffrey E; McMasters, Kelly M; Michaelson, James S; Stromberg, Arnold J; Panageas, Katherine S

2018-02-22

Prognostic models are increasingly being made available online, where they can be publicly accessed by both patients and clinicians. These online tools are an important resource for patients to better understand their prognosis and for clinicians to make informed decisions about treatment and follow-up. The goal of this analysis was to highlight the possible variability in multiple online prognostic tools in a single disease. To demonstrate the variability in survival predictions across online prognostic tools, we applied a single validation dataset to three online melanoma prognostic tools. Data on melanoma patients treated at Memorial Sloan Kettering Cancer Center between 2000 and 2014 were retrospectively collected. Calibration was assessed using calibration plots and discrimination was assessed using the C-index. In this demonstration project, we found important differences across the three models that led to variability in individual patients' predicted survival across the tools, especially in the lower range of predictions. In a validation test using a single-institution data set, calibration and discrimination varied across the three models. This study underscores the potential variability both within and across online tools, and highlights the importance of using methodological rigor when developing a prognostic model that will be made publicly available online. The results also reinforce that careful development and thoughtful interpretation, including understanding a given tool's limitations, are required in order for online prognostic tools that provide survival predictions to be a useful resource for both patients and clinicians.

Serious Infections in Patients Receiving Ibrutinib for Treatment of Lymphoid Malignancies.

Science.gov (United States)

Varughese, Tilly; Taur, Ying; Cohen, Nina; Palomba, M Lia; Seo, Susan K; Hohl, Tobias M; Redelman-Sidi, Gil

2018-03-02

Ibrutinib is a Bruton's tyrosine kinase inhibitor that is used for the treatment of lymphoid malignancies, including chronic lymphocytic leukemia (CLL), Waldenström's macroglobulinemia and mantle cell lymphoma (MCL). Several case series have described opportunistic infections among ibrutinib recipients, but the full extent of these infections is unknown. We sought to determine the spectrum of serious infections associated with ibrutinib treatment. We reviewed the electronic medical records of patients with lymphoid malignancies at Memorial Sloan Kettering Cancer Center who received ibrutinib during a five-year period from January 1, 2012 to December 31, 2016. Serious infections were identified by review of the relevant microbiology, clinical laboratory, and radiology data. Risk factors for infection were determined by univariate and multivariate analyses. 378 patients with lymphoid malignancies who received ibrutinib were analyzed. The most common underlying malignancies were CLL and MCL. 84% of patients received ibrutinib as monotherapy. Serious infection developed in 43 patients (11.4%), primarily during the first year of ibrutinib treatment. Of these, 23 (53.5%) developed invasive bacterial infections, and 16 (37.2%) developed invasive fungal infections (IFI). The majority of those who developed IFI on ibrutinib therapy (62.5%) lacked classical clinical risk factors for fungal infection (i.e., neutropenia, lymphopenia, and receipt of corticosteroids). Infection resulted in death in six of the 43 patients (14%). Patients with lymphoid malignancies receiving ibrutinib treatment are at risk for serious infections, including IFI.

Implanted Cardiac Defibrillator Care in Radiation Oncology Patient Population

International Nuclear Information System (INIS)

Gelblum, Daphna Y.; Amols, Howard

2009-01-01

Purpose: To review the experience of a large cancer center with radiotherapy (RT) patients bearing implantable cardiac defibrillators (ICDs) to propose some preliminary care guidelines as we learn more about the devices and their interaction with the therapeutic radiation environment. Methods and Materials: We collected data on patients with implanted ICDs treated with RT during a 2.5-year period at any of the five Memorial Sloan-Kettering clinical campuses. Information regarding the model, location, and dose detected from the device, as well as the treatment fields, fraction size, and treatment energy was collected. During this time, a new management policy for these patients had been implemented requiring treatment with low-energy beams (6 MV) and close surveillance of the patients in partnership with their electrophysiologist, as they received RT. Results: During the study period, 33 patients were treated with an ICD in place. One patient experienced a default of the device to its initial factory setting that was detected by the patient hearing an auditory signal from the device. This patient had initially been treated with a 15-MV beam. After this episode, his treatment was replanned to be completed with 6-MV photons, and he experienced no further events. Conclusion: Patients with ICDs and other implanted computer-controlled devices will be encountered more frequently in the RT department, and proper management is important. We present a policy for the safe treatment of these patients in the radiation oncology environment.

Adult Rhabdomyosarcoma Survival Improved With Treatment on Multimodality Protocols

Energy Technology Data Exchange (ETDEWEB)

Gerber, Naamit Kurshan [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Wexler, Leonard H. [Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Singer, Samuel [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Alektiar, Kaled M. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Keohan, Mary Louise [Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Shi, Weiji; Zhang, Zhigang [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Wolden, Suzanne, E-mail: woldens@mskcc.org [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)

2013-05-01

Purpose: Rhabdomyosarcoma (RMS) is a pediatric sarcoma rarely occurring in adults. For unknown reasons, adults with RMS have worse outcomes than do children. Methods and Materials: We analyzed data from all patients who presented to Memorial Sloan-Kettering Cancer Center between 1990 and 2011 with RMS diagnosed at age 16 or older. One hundred forty-eight patients met the study criteria. Ten were excluded for lack of adequate data. Results: The median age was 28 years. The histologic diagnoses were as follows: embryonal 54%, alveolar 33%, pleomorphic 12%, and not otherwise specified 2%. The tumor site was unfavorable in 67% of patients. Thirty-three patients (24%) were at low risk, 61 (44%) at intermediate risk, and 44 (32%) at high risk. Forty-six percent were treated on or according to a prospective RMS protocol. The 5-year rate of overall survival (OS) was 45% for patients with nonmetastatic disease. The failure rates at 5 years for patients with nonmetastatic disease were 34% for local failure and 42% for distant failure. Among patients with nonmetastatic disease (n=94), significant factors associated with OS were histologic diagnosis, site, risk group, age, and protocol treatment. On multivariate analysis, risk group and protocol treatment were significant after adjustment for age. The 5-year OS was 54% for protocol patients versus 36% for nonprotocol patients. Conclusions: Survival in adult patients with nonmetastatic disease was significantly improved for those treated on RMS protocols, most of which are now open to adults.

Germline Variants in Targeted Tumor Sequencing Using Matched Normal DNA.

Science.gov (United States)

Schrader, Kasmintan A; Cheng, Donavan T; Joseph, Vijai; Prasad, Meera; Walsh, Michael; Zehir, Ahmet; Ni, Ai; Thomas, Tinu; Benayed, Ryma; Ashraf, Asad; Lincoln, Annie; Arcila, Maria; Stadler, Zsofia; Solit, David; Hyman, David M; Hyman, David; Zhang, Liying; Klimstra, David; Ladanyi, Marc; Offit, Kenneth; Berger, Michael; Robson, Mark

2016-01-01

Tumor genetic sequencing identifies potentially targetable genetic alterations with therapeutic implications. Analysis has concentrated on detecting tumor-specific variants, but recognition of germline variants may prove valuable as well. To estimate the burden of germline variants identified through routine clinical tumor sequencing. Patients with advanced cancer diagnoses eligible for studies of targeted agents at Memorial Sloan Kettering Cancer Center are offered tumor-normal sequencing with MSK-IMPACT, a 341-gene panel. We surveyed the germline variants seen in 187 overlapping genes with Mendelian disease associations in 1566 patients who had undergone tumor profiling between March and October 2014. The number of presumed pathogenic germline variants (PPGVs) and variants of uncertain significance per person in 187 genes associated with single-gene disorders and the proportions of individuals with PPGVs in clinically relevant gene subsets, in genes consistent with known tumor phenotypes, and in genes with evidence of second somatic hits in their tumors. The mean age of the 1566 patients was 58 years, and 54% were women. Presumed pathogenic germline variants in known Mendelian disease-associated genes were identified in 246 of 1566 patients (15.7%; 95% CI, 14.0%-17.6%), including 198 individuals with mutations in genes associated with cancer susceptibility. Germline findings in cancer susceptibility genes were concordant with the individual's cancer type in only 81 of 198 cases (40.9%; 95% CI, 34.3%-47.9%). In individuals with PPGVs retained in the tumor, somatic alteration of the other allele was seen in 39 of 182 cases (21.4%; 95% CI, 16.1%-28.0%), of which 13 cases did not show a known correlation of the germline mutation and a known syndrome. Mutations in non-cancer-related Mendelian disease genes were seen in 55 of 1566 cases (3.5%; 95% CI, 27.1%-45.4%). Almost every individual had more than 1 variant of uncertain significance (1565 of 1566 patients; 99

Stress, Psychosocial Mediators, and Cognitive Mediators in Parents of Child Cancer Patients and Cancer Survivors: Attention and Working Memory Pathway Perspectives.

Science.gov (United States)

Vander Haegen, Marie; Luminet, Olivier

2015-01-01

This review examines stress and its consequences on attention and working memory, stress symptoms in parents of child cancer patients and survivors and long-term consequences of stress on cognitive processing in parents of child cancer survivors. Eligible studies were experimental, meta-analyses, and qualitative (2000-2013) from Pubmed, Medline, the Cochrane Library, PsycArticles, and Google Scholar. We identified 92 eligible papers. They showed that elevated stress can impede performances on tasks requiring attention and memory patterns. In pediatric oncology, parental stress increased shortly after diagnosis involving depression and anxiety. Consequences of stress on cognitive performances were observed mainly among depressed individuals. As regards parents of child cancer survivors, female gender, low Socioeconomic Status (SES), and innate traits of anxiety/anger predicted the development of PTSS. Evidence of stress on attention and working memory processes in parents of child cancer survivors is insufficiently developed.

Clinical Application of Picodroplet Digital PCR Technology for Rapid Detection of EGFR T790M in Next-Generation Sequencing Libraries and DNA from Limited Tumor Samples.

Science.gov (United States)

Borsu, Laetitia; Intrieri, Julie; Thampi, Linta; Yu, Helena; Riely, Gregory; Nafa, Khedoudja; Chandramohan, Raghu; Ladanyi, Marc; Arcila, Maria E

2016-11-01

Although next-generation sequencing (NGS) is a robust technology for comprehensive assessment of EGFR-mutant lung adenocarcinomas with acquired resistance to tyrosine kinase inhibitors, it may not provide sufficiently rapid and sensitive detection of the EGFR T790M mutation, the most clinically relevant resistance biomarker. Here, we describe a digital PCR (dPCR) assay for rapid T790M detection on aliquots of NGS libraries prepared for comprehensive profiling, fully maximizing broad genomic analysis on limited samples. Tumor DNAs from patients with EGFR-mutant lung adenocarcinomas and acquired resistance to epidermal growth factor receptor inhibitors were prepared for Memorial Sloan-Kettering-Integrated Mutation Profiling of Actionable Cancer Targets sequencing, a hybrid capture-based assay interrogating 410 cancer-related genes. Precapture library aliquots were used for rapid EGFR T790M testing by dPCR, and results were compared with NGS and locked nucleic acid-PCR Sanger sequencing (reference high sensitivity method). Seventy resistance samples showed 99% concordance with the reference high sensitivity method in accuracy studies. Input as low as 2.5 ng provided a sensitivity of 1% and improved further with increasing DNA input. dPCR on libraries required less DNA and showed better performance than direct genomic DNA. dPCR on NGS libraries is a robust and rapid approach to EGFR T790M testing, allowing most economical utilization of limited material for comprehensive assessment. The same assay can also be performed directly on any limited DNA source and cell-free DNA. Copyright © 2016 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

Review of Recent US Value Frameworks-A Health Economics Approach: An ISPOR Special Task Force Report [6].

Science.gov (United States)

Willke, Richard J; Neumann, Peter J; Garrison, Louis P; Ramsey, Scott D

2018-02-01

The sixth section of our Special Task Force (STF) report reviews and comments on recent US-oriented value assessment frameworks, specifically those published by the American College of Cardiology/American Heart Association, the Institute for Clinical and Economic Research, the American Society of Clinical Oncology, the National Comprehensive Cancer Network, and the Memorial Sloan Kettering Cancer Center. We review published commentaries that address the validity, reliability, and conceptual underpinnings of these frameworks. We find common themes of critique regarding the strengths and limitations across frameworks. Particular shortcomings of some frameworks pose greater threats to their face validity and utility compared with others. The most significant limitations include lack of clear perspective (e.g., patient vs. health plan) and poor transparency in accounting for costs and benefits. We then review how each framework adheres to core STF recommendations, with particular emphasis on whether the framework can be used to support coverage decisions by health insurers, and whether it adheres to core principles of cost-effectiveness analysis. The Institute for Clinical and Economic Research framework most closely adheres to core STF recommendations. Others have significant limitations that vary widely from framework to framework. We also review how the frameworks follow STF recommendations for addressing potentially relevant issues beyond cost-effectiveness analysis - for example, equity in resource allocation and patient heterogeneity. Finally, we review whether and how each framework uses value thresholds and addresses affordability concerns. We conclude with suggestions for further research, particularly in the areas of testing the measurement and use of novel elements of value and deliberative processes. Copyright © 2018 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

New roles & responsibilities of hospital biomedical engineering.

Science.gov (United States)

Frisch, P H; Stone, B; Booth, P; Lui, W

2014-01-01

Over the last decade the changing healthcare environment has required hospitals and specifically Biomedical Engineering to critically evaluate, optimize and adapt their operations. The focus is now on new technologies, changes to the environment of care, support requirements and financial constraints. Memorial Sloan Kettering Cancer Center (MSKCC), an NIH-designated comprehensive cancer center, has been transitioning to an increasing outpatient care environment. This transition is driving an increase in-patient acuity coupled with the need for added urgency of support and response time. New technologies, regulatory requirements and financial constraints have impacted operating budgets and in some cases, resulted in a reduction in staffing. Specific initiatives, such as the Joint Commission's National Patient Safety Goals, requirements for an electronic medical record, meaningful use and ICD10 have caused institutions to reevaluate their operations and processes including requiring Biomedical Engineering to manage new technologies, integrations and changes in the electromagnetic environment, while optimizing operational workflow and resource utilization. This paper addresses the new and expanding responsibilities and approach of Biomedical Engineering organizations, specifically at MSKCC. It is suggested that our experience may be a template for other organizations facing similar problems. Increasing support is necessary for Medical Software - Medical Device Data Systems in the evolving wireless environment, including RTLS and RFID. It will be necessary to evaluate the potential impact on the growing electromagnetic environment, on connectivity resulting in the need for dynamic and interactive testing and the growing demand to establish new and needed operational synergies with Information Technology operations and other operational groups within the institution, such as nursing, facilities management, central supply, and the user departments.

Ovarian function in survivors of childhood medulloblastoma: Impact of reduced dose craniospinal irradiation and high-dose chemotherapy with autologous stem cell rescue.

Science.gov (United States)

Balachandar, Sadana; Dunkel, Ira J; Khakoo, Yasmin; Wolden, Suzanne; Allen, Jeffrey; Sklar, Charles A

2015-02-01

Data on ovarian function (OvF) in medulloblastoma (MB) survivors is limited, with most studies describing outcomes in survivors treated with craniospinal irradiation (CSI) doses >24 Gy ± standard chemotherapy. The objective of the current study is to report on OvF: (i) across a range of CSI doses; and (ii) following high-dose chemotherapy with autologous stem cell rescue (ASCR). Retrospective review of female MB survivors who were diagnosed in childhood and followed at Memorial Sloan Kettering Cancer Center. Patients were divided into three groups: (i) CSI ≤24 Gy +/- standard chemotherapy; (ii) CSI ≥35 Gy +/- standard chemotherapy; and (iii) high-dose chemotherapy with ASCR +/- CSI. Primary ovarian dysfunction (POD) occurred in 2/17 subjects in group 1, 3/9 subjects in group 2 and 5/5 subjects in group 3 (P < 0.01). Normalization of function was noted in four subjects with POD. Persistent POD requiring hormone replacement (POF) was observed in 1/17 subjects in group 1, 2/9 in group 2, and 3/5 in group 3 (P = 0.02). Neither age at treatment nor type of standard chemotherapy correlated with risk of POD or POF. Both POD and POF appear to occur in a small proportion of patients who are treated with contemporary doses of CSI +/- standard chemotherapy. However, ovarian dysfunction requiring hormone replacement therapy is common following high-dose chemotherapy associated with ASCR. These findings will assist clinicians in counseling patients regarding fertility preservation and risk of impaired ovarian function/future fertility. Pediatr Blood Cancer 2015;62:317-321. © 2014 Wiley Periodicals, Inc. © 2014 Wiley Periodicals, Inc.

Analysis of memory deficits following chemotherapy in breast cancer survivors: evidence from the doors and people test.

Science.gov (United States)

Prokasheva, Svetlana; Faran, Yifat; Cwikel, Julie; Geffen, David B

2011-01-01

Studies of cognitive effects of chemotherapy among breast cancer patients show that not all women who are exposed to chemotherapy develop cognitive dysfunction and that the observed declines in cognitive functioning may be quite subtle. The use of measures that are sensitive to subtle cognitive decline are recommended yet rarely used among clinical populations. The purpose of this study is to specify the types of memory changes observed among breast cancer survivors treated with chemotherapy and tamoxifen, by using an analytic test of memory, the Doors and People test, which uses age-adjusted norms. The participants were 40 women who were survivors of breast cancer, 20 of whom had completed chemotherapy treatment and 20 women who were treated only with tamoxifen. There were no significant differences between the two groups in overall scores and in all four subtests: visual memory, verbal memory, recall, and recognition measured by age-adjusted scores. Forty percent of patients in both of the groups were classified as having mild impairment in episodic memory. No between-group differences were found in the frequency of subjective, cognitive complaints. Subjective complaints were reported by 69% of patients but were unrelated to objective performance. Memory deficits were observed in breast cancer patients who receive either chemotherapy or tamoxifen alone compared to age-adjusted norms. The Doors and People Test is a sensitive measure of memory deficits that is feasible for use with clinical populations of breast cancer patients in order to monitor changes in cognitive function.

Sloan Digital Sky Survey Photometric Calibration Revisited

International Nuclear Information System (INIS)

Marriner, John

2012-01-01

The Sloan Digital Sky Survey calibration is revisited to obtain the most accurate photometric calibration. A small but significant error is found in the flat-fielding of the Photometric telescope used for calibration. Two SDSS star catalogs are compared and the average difference in magnitude as a function of right ascension and declination exhibits small systematic errors in relative calibration. The photometric transformation from the SDSS Photometric Telescope to the 2.5 m telescope is recomputed and compared to synthetic magnitudes computed from measured filter bandpasses.

Sloan Digital Sky Survey Photometric Calibration Revisited

Energy Technology Data Exchange (ETDEWEB)

Marriner, John; /Fermilab

2012-06-29

The Sloan Digital Sky Survey calibration is revisited to obtain the most accurate photometric calibration. A small but significant error is found in the flat-fielding of the Photometric telescope used for calibration. Two SDSS star catalogs are compared and the average difference in magnitude as a function of right ascension and declination exhibits small systematic errors in relative calibration. The photometric transformation from the SDSS Photometric Telescope to the 2.5 m telescope is recomputed and compared to synthetic magnitudes computed from measured filter bandpasses.

Current and emerging treatment options for nasopharyngeal carcinoma

Directory of Open Access Journals (Sweden)

Spratt DE

2012-10-01

Full Text Available Daniel E Spratt, Nancy LeeDepartment of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USAAbstract: In this article, we focus on the current and emerging treatments in nasopharyngeal cancer (NPC. A detailed evolution of the current standard of care, and new techniques and treatment options will be reviewed. Intergroup 0099 established the role for chemoradiotherapy (chemo-RT in the treatment of nasopharyngeal carcinoma. Multiple randomized Phase III trials have shown the benefit of chemo-RT; however, none of these studies utilized modern radiotherapy (RT techniques of intensity-modulated radiation therapy (IMRT. IMRT has the ability to deliver high doses of radiation to the target structures while sparing adjacent bystander healthy tissues, and has now become the preferred RT treatment modality. Chemotherapy also has had a shifting paradigm of induction and/or adjuvant chemotherapy combined with RT alone, to the investigation with concurrent chemo-RT. New treatment options including targeted monoclonal antibodies and small molecule tyrosine kinase inhibitors are being studied in NPC. These new biologic therapies have promising in vitro activity for NPC, and emerging clinical studies are beginning to define their role. RT continues to expand its capabilities, and since IMRT and particle therapy, specifically intensity-modulated proton therapy (IMPT, has reports of impressive dosimetric efficacy in-silica. Adaptive RT is attempting to reduce toxicity while maintaining treatment efficacy, and the clinical results are still in their youth. Lastly, Epstein–Barr virus (EBV DNA has recently been studied for prediction of tumor response and its use as a biomarker is increasingly promising to aid in early detection as well as supplementing the current staging system. RT with or without chemotherapy remains the standard of care for nasopharyngeal carcinoma. Advances in RT technique, timing of chemotherapy, biologically

Nuclear-specific AR-V7 Protein Localization is Necessary to Guide Treatment Selection in Metastatic Castration-resistant Prostate Cancer.

Science.gov (United States)

Scher, Howard I; Graf, Ryon P; Schreiber, Nicole A; McLaughlin, Brigit; Lu, David; Louw, Jessica; Danila, Daniel C; Dugan, Lyndsey; Johnson, Ann; Heller, Glenn; Fleisher, Martin; Dittamore, Ryan

2017-06-01

Circulating tumor cells (CTCs) expressing AR-V7 protein localized to the nucleus (nuclear-specific) identify metastatic castration-resistant prostate cancer (mCRPC) patients with improved overall survival (OS) on taxane therapy relative to the androgen receptor signaling inhibitors (ARSi) abiraterone acetate, enzalutamide, and apalutamide. To evaluate if expanding the positivity criteria to include both nuclear and cytoplasmic AR-V7 localization ("nuclear-agnostic") identifies more patients who would benefit from a taxane over an ARSi. The study used a cross-sectional cohort. Between December 2012 and March 2015, 193 pretherapy blood samples, 191 of which were evaluable, were collected and processed from 161 unique mCRPC patients before starting a new line of systemic therapy for disease progression at the Memorial Sloan Kettering Cancer Center. The association between two AR-V7 scoring criteria, post-therapy prostate-specific antigen (PSA) change (PTPC) and OS following ARSi or taxane treatment, was explored. One criterion required nuclear-specific AR-V7 localization, and the other required an AR-V7 signal but was agnostic to protein localization in CTCs. Correlation of AR-V7 status to PTPC and OS was investigated. Relationships with survival were analyzed using multivariable Cox regression and log-rank analyses. A total of 34 (18%) samples were AR-V7-positive using nuclear-specific criteria, and 56 (29%) were AR-V7-positive using nuclear-agnostic criteria. Following ARSi treatment, none of the 16 nuclear-specific AR-V7-positive samples and six of the 32 (19%) nuclear-agnostic AR-V7-positive samples had ≥50% PTPC at 12 weeks. The strongest baseline factor influencing OS was the interaction between the presence of nuclear-specific AR-V7-positive CTCs and treatment with a taxane (hazard ratio 0.24, 95% confidence interval 0.078-0.79; p=0.019). This interaction was not significant when nuclear-agnostic criteria were used. To reliably inform treatment selection

Comparison of the unitary pole and Adhikari-Sloan expansions in the three nucleon system

International Nuclear Information System (INIS)

Afnan, I.R.; Birrell, N.D.

1977-01-01

The binding energy of 3 H, percentage S-, S'- and D-state probability, and charge form factor of 3 He are calculated using the unitary pole and Adhikari-Sloan separable expansions to the Reid soft core potential. Comparison of the results for the two separable expansions show that the expansion of Adhikari and Sloan has the better convergence property, and the lowest rank expansion considered (equivalent to the unitary pole approximation) gives a good approximation to the binding energy of 3 H and the charge form factor of 3 He, even at large momentum transfer (K 2 -2 ). (Author)

The Fourteenth Data Release of the Sloan Digital Sky Survey

DEFF Research Database (Denmark)

Abolfathi, Bela; Aguado, D. S.; Aguilar, Gabriela

2018-01-01

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since 2014 July. This paper describes the second data release from this phase, and the 14th from SDSS overall (making this Data Release Fourteen or DR14). This release makes the data taken by SDSS-IV in its firs...

Recent advances in radioiodine use for the management of thyroid carcinoma

International Nuclear Information System (INIS)

Chung, J.K.

2007-01-01

Full text: It has been well accepted that radioiodine is useful in the management of patients with recurrent or metastatic differentiated thyroid cancer. Although radioiodine has been used for more than 60 years in diagnosis and treatment, some improvements still appear continuously. Serum Thyroglobulin (Tg) and radioiodine whole body scans (WBS) are used to detect recurrent thyroid caner. Tg has been known to be more sensitive than WBS, and false negative WBS with elevated Tg are frequently found. However, the clinical importance of Tg negative cases with positive WBS has not been clarified. We found that 34 among 960 patients who showed negative Tg with positive post-therapy I-131 WBS had functioning metastases to extrathyroidal organs. Complementary use of radioiodine WBS is recommended to exclude Tg false negative cases. The retinoic acid (RA) is well known to induce the cellular re-differentiation and increase the expression of sodium/iodide symporter (NIS) in de-differentiated tumor cell. We performed RA treatment with I-131 in 40 patients with elevated serum Tg level but no focal iodine uptake in WBS. In 14 patients (35%), improved I-131 uptake was seen. Focal iodine uptakes were seen in 4 patients, and diffuse hepatic visualization without localized lesions were found in 10 patients. Maximal safe dose (MSD) administration based on bone marrow radiation allows the delivery of a large amount of I-131 to thyroid cancer tissue within the safety margin. We performed MSD therapy in 46 patients with differentiated thyroid cancers, which had persisted even after conventional fixed dose therapy. MSD was calculated according to the Memorial Sloan Kettering Cancer Center protocol using blood samples. Mean calculated MSD was 12.5±2.1 GBq (337.3±37.5 mCi). Of the 46 patients, 6 (13.0%) showed complete remission, 15 (32.6%) partial response, 19 stable disease, and 6 disease progression. Twenty-nine patients (63%) had a transient cytopenia after therapy. MSD therapy of

Parameningeal rhabdomyosarcoma (including the orbit): results of orbital irradiation

International Nuclear Information System (INIS)

Jereb, B.; Haik, B.G.; Ong, R.; Ghavimi, F.

1985-01-01

Twenty-three patients with parameningeal (including orbital rhabdomyosarcoma (RMS)) were treated at Memorial Sloan-Kettering Cancer Center (MSKCC) between July 1971 and January 1983. Twenty were children with a mean age of 6 and 3 were adults. In 6 patients, the primary tumor was from the orbit, whereas the remaining 17 had other parameningeal primary sites. The tumors were in a very progressive local stage, with extensive destruction of the facial bones in 19 patients. Eight patients were treated with T2 chemotherapy protocol and 15 received T6. Seven patients received 5,000 to 7,200 rad delivered to the primary tumor in 11-16 weeks, 15 patients received between 4,500 to 5,000 rad in 4-7 weeks, and 1 patient received 3,000 rad in 3 weeks for residual microscopic disease following surgery. Two patients were treated with radiation to the whole brain; no patients received radiation of the whole central nervous axis (CNA). Fifteen of the 23 patients (65%) are alive and well with a medical follow-up time of 5 years. Two patients died of therapeutic complications and six died of tumor spread. In five patients, involvement of the central nervous system (CNS) was the cause of death. The prognosis of orbital RMS with parameningeal involvement is no better than in other tumors of parameningeal sites. In those patients who had impaired vision because of optic nerve damage prior to treatment, the vision did not improve following treatment. There was no impaired vision seen due to radiation damage of eye structures except in the lens

Contrast Media Use in Radiation Oncology: A Prospective, Controlled Educational Intervention Study with Retrospective Analysis of Patient Outcomes

Science.gov (United States)

Barker, Christopher A.; Mutter, Robert W.; Shapiro, Lauren Q.; Zhang, Zhigang; Wolden, Suzanne L.; Yahalom, Joachim

2016-01-01

Purpose Intravenous contrast media (ICM) administration is recommended as part of radiation therapy (RT) simulation in a variety of clinical scenarios, but can cause adverse events. We sought to assess radiation oncology resident knowledge about ICM, and to determine if an educational intervention (EI) could improve this level of knowledge. In conjunction, we retrospectively analyzed risk factors and adverse events related to ICM use before and after the EI to determine whether any improvements in patient outcomes could be realized. Methods Over 2 years, 21 residents in radiation oncology at Memorial Sloan-Kettering Cancer Center (MSKCC) participated in a pretest-EI-posttest study based on the ACR’s Manual on Contrast Media. Medical and RT records were reviewed, and ICM use, risk factors and adverse events were recorded. Results There was no significant difference in resident understanding of ICM use in residents of different years of training (p=0.85). Understanding of ICM use increased in residents that attended the EI (p<0.05), but this was not sustained 1 year after the EI (p=0.48). Of the 6852 RT simulations that were performed at MSKCC, 1350 (19.7%) involved ICM. Mild adverse events occurred in a few patients (<5%) simulated with ICM, but there was no difference in the number of risk factors or adverse events before and after the EI. Conclusions The EI effectively improved short-term understanding of ICM use. However, the effect was not sustained. The frequency of adverse events related to ICM use was small and not significantly impacted by the EI. PMID:21129689

Predicting Outcome in Patients with Rhabdomyosarcoma: Role of [18F]Fluorodeoxyglucose Positron Emission Tomography

International Nuclear Information System (INIS)

Casey, Dana L.; Wexler, Leonard H.; Fox, Josef J.; Dharmarajan, Kavita V.; Schoder, Heiko; Price, Alison N.; Wolden, Suzanne L.

2014-01-01

Purpose: To evaluate whether [ 18 F]fluorodeoxyglucose positron emission tomography (FDG-PET) response of the primary tumor after induction chemotherapy predicts outcomes in rhabdomyosarcoma (RMS). Methods and Materials: After excluding those with initial tumor resection, 107 patients who underwent FDG-PET after induction chemotherapy at Memorial Sloan Kettering Cancer Center from 2002 to 2013 were reviewed. Local control (LC), progression-free survival (PFS), and overall survival (OS) were calculated according to FDG-PET response and maximum standardized uptake value (SUV) at baseline (PET1/SUV1), after induction chemotherapy (PET2/SUV2), and after local therapy (PET3/SUV3). Receiver operator characteristic curves were used to determine the optimal cutoff for dichotomization of SUV1 and SUV2 values. Results: The SUV1 (<9.5 vs ≥9.5) was predictive of PFS (P=.02) and OS (P=.02), but not LC. After 12 weeks (median) of induction chemotherapy, 45 patients had negative PET2 scans and 62 had positive scans: 3-year PFS was 72% versus 44%, respectively (P=.01). The SUV2 (<1.5 vs ≥1.5) was similarly predictive of PFS (P=.005) and was associated with LC (P=.02) and OS (P=.03). A positive PET3 scan was predictive of worse PFS (P=.0009), LC (P=.05), and OS (P=.03). Conclusions: [ 18 F]fluorodeoxyglucose positron emission tomography is an early indicator of outcomes in patients with RMS. Future prospective trials may incorporate FDG-PET response data for risk-adapted therapy and early assessment of new treatment regimens

Quantitative method for the determination of Iso-fludelone (KOS-1803) in human plasma by LC-MS/MS

Science.gov (United States)

Christner, Susan M.; Parise, Robert A.; Levine, Erica D.; Rizvi, Naiyer A.; Gounder, Mrinal M.; Beumer, Jan H.

2014-01-01

Epothilones are relatively new tubulin-poison anticancer drugs. Iso-fludelone (KOS-1803) is a synthetic third generation epothilone drug discovered at Memorial Sloan Kettering Cancer Center, and currently in Phase I clinical trials. We report an LC-MS/MS assay for the sensitive, accurate and precise quantitation of Iso-fludelone in 0.2 mL of human plasma. Validation was performed according to FDA guidance. The assay comprised of KOS-1724 as the internal standard and an MTBE liquid-liquid extraction with a water wash step. Separation was achieved with an YMC-Pack ODS-AQ column and an isocratic mobile phase of 0.1% formic acid in acetonitrile and water (70:30, v/v) at 0.3 mL/min for 4 min. Chromatographic separation was followed by electrospray, positive-mode ionization tandem mass spectrometric detection in the multiple reaction monitoring (MRM) mode. The assay was linear from 0.1– 300 ng/mL and was accurate (−9.41–7.07%) and precise (1.03–13.7%) which fulfilled FDA criteria for validation. Recovery from plasma was 73.9–79.7% and ion suppression was negligible (−22.8 to −31.3%). Plasma freeze thaw stability (99.97–105.7%), stability for 11 months at −80 °C (94.93–107.9%), and stability for 6 h at room temperature (94.75–105.5%) were all acceptable. This assay is currently being applied to quantitate Iso-fludelone in clinical samples. PMID:25168219

Quantitative method for the determination of iso-fludelone (KOS-1803) in human plasma by LC-MS/MS.

Science.gov (United States)

Christner, Susan M; Parise, Robert A; Levine, Erica D; Rizvi, Naiyer A; Gounder, Mrinal M; Beumer, Jan H

2014-11-01

Epothilones are relatively new tubulin-poison anticancer drugs. Iso-fludelone (KOS-1803) is a synthetic third generation epothilone drug discovered at Memorial Sloan Kettering Cancer Center, and currently in phase I clinical trials. We report an LC-MS/MS assay for the sensitive, accurate and precise quantitation of iso-fludelone in 0.2mL of human plasma. Validation was performed according to FDA guidance. The assay comprised of KOS-1724 as the internal standard and an MTBE liquid-liquid extraction with a water wash step. Separation was achieved with an YMC-Pack ODS-AQ column and an isocratic mobile phase of 0.1% formic acid in acetonitrile and water (70:30, v/v) at 0.3mL/min for 4min. Chromatographic separation was followed by electrospray, positive-mode ionization tandem mass spectrometric detection in the multiple reaction monitoring (MRM) mode. The assay was linear from 0.1 to 300ng/mL and was accurate (-9.41 to -7.07%) and precise (1.03-13.7%) which fulfilled FDA criteria for validation. Recovery from plasma was 73.9-79.7% and ion suppression was negligible (-22.8 to -31.3%). Plasma freeze-thaw stability (99.97-105.7%), stability for 11 months at -80°C (94.93-107.9%), and stability for 6h at room temperature (94.75-105.5%) were all acceptable. This assay is currently being applied to quantitate iso-fludelone in clinical samples. Copyright © 2014 Elsevier B.V. All rights reserved.

Prospective Evaluation of Nutritional Factors to Predict the Risk of Complications for Patients Undergoing Radical Cystectomy: A Cohort Study.

Science.gov (United States)

Allaire, Janie; Léger, Caroline; Ben-Zvi, Tal; Nguilé-Makao, Molière; Fradet, Yves; Lacombe, Louis; Fradet, Vincent

2017-01-01

The objective of this study was to identify nutritional preoperative factors associated with complications after radical cystectomy (RC). We prospectively evaluated the Mini-Nutritional Assessment Score, body mass index (BMI), appetite, stool frequency, hydration, food intake, weight loss, albuminemia, and prealbuminemia of 144 patients who underwent RC between January 2011 and April 2014. Postoperative complications were defined as any adverse event reported in the patient's file up to 90 days after surgery. Each complication was classified according to the Clavien-Dindo and Memorial Sloan-Kettering Cancer Center systems. The adjusted relative risk (RR) computed through a Poisson regression model was used to identify nutritional risk factors associated with post-RC complications. A high BMI >27 kg/m 2 was associated with higher risk of low-grade complications (RR:1.47 [95% CI,1.09-2.00]) at 7 days and a four-fold increased risk of cardiac complications at 7 and 90 days (RR:3.77 [1.15-12.32] and RR:3.28 [1.35-7.98]). Decreased appetite was associated with low-grade (RR:1.43 [1.03-1.99] complications within 90 days. Preoperative weight loss >3 kg was associated with high-grade (RR:2.49 [1.23-5.05]) and wound (RR:2.51 [1.23-5.10]) complications within 90 days. This study showed that preoperative nutritional status of patients may predict the occurrence of complications up to 90 days post-RC. Development of preoperative nutritional interventions may reduce the deleterious impact of RC on patients' health.

A Health Economics Approach to US Value Assessment Frameworks-Introduction: An ISPOR Special Task Force Report [1].

Science.gov (United States)

Neumann, Peter J; Willke, Richard J; Garrison, Louis P

2018-02-01

Concerns about rising spending on prescription drugs and other areas of health care have led to multiple initiatives in the United States designed to measure and communicate the value of pharmaceuticals and other technologies for decision making. In this section we introduce the work of the International Society for Pharmacoeconomics and Outcomes Research Special Task Force on US Value Assessment Frameworks formed to review relevant perspectives and appropriate approaches and methods to support the definition and use of high-quality value frameworks. The Special Task Force was part of the International Society for Pharmacoeconomics and Outcomes Research Initiative on US Value Assessment Frameworks, which enlisted the expertise of leading health economists, concentrating on what the field of health economics can provide to help inform the development and use of value assessment frameworks. We focus on five value framework initiatives: the American College of Cardiology/American Heart Association, the American Society of Clinical Oncology, the Institute for Clinical and Economic Review, the Memorial Sloan Kettering Cancer Center, and the National Comprehensive Cancer Network. These entities differ in their missions, scope of activities, and methodological approaches. Because they are gaining visibility and some traction in the United States, it is essential to scrutinize whether the frameworks use approaches that are transparent as well as conceptually and methodologically sound. Our objectives were to describe the conceptual bases for value and its use in decision making, critically examine existing value frameworks, discuss the importance of sound conceptual underpinning, identify key elements of value relevant to specific decision contexts, and recommend good practice in value definition and implementation as well as areas for further research. Copyright © 2018 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc

Multi-institutional validation of a novel textural analysis tool for preoperative stratification of suspected thyroid tumors on diffusion-weighted MRI.

Science.gov (United States)

Brown, Anna M; Nagala, Sidhartha; McLean, Mary A; Lu, Yonggang; Scoffings, Daniel; Apte, Aditya; Gonen, Mithat; Stambuk, Hilda E; Shaha, Ashok R; Tuttle, R Michael; Deasy, Joseph O; Priest, Andrew N; Jani, Piyush; Shukla-Dave, Amita; Griffiths, John

2016-04-01

Ultrasound-guided fine needle aspirate cytology fails to diagnose many malignant thyroid nodules; consequently, patients may undergo diagnostic lobectomy. This study assessed whether textural analysis (TA) could noninvasively stratify thyroid nodules accurately using diffusion-weighted MRI (DW-MRI). This multi-institutional study examined 3T DW-MRI images obtained with spin echo echo planar imaging sequences. The training data set included 26 patients from Cambridge, United Kingdom, and the test data set included 18 thyroid cancer patients from Memorial Sloan Kettering Cancer Center (New York, New York, USA). Apparent diffusion coefficients (ADCs) were compared over regions of interest (ROIs) defined on thyroid nodules. TA, linear discriminant analysis (LDA), and feature reduction were performed using the 21 MaZda-generated texture parameters that best distinguished benign and malignant ROIs. Training data set mean ADC values were significantly different for benign and malignant nodules (P = 0.02) with a sensitivity and specificity of 70% and 63%, respectively, and a receiver operator characteristic (ROC) area under the curve (AUC) of 0.73. The LDA model of the top 21 textural features correctly classified 89/94 DW-MRI ROIs with 92% sensitivity, 96% specificity, and an AUC of 0.97. This algorithm correctly classified 16/18 (89%) patients in the independently obtained test set of thyroid DW-MRI scans. TA classifies thyroid nodules with high sensitivity and specificity on multi-institutional DW-MRI data sets. This method requires further validation in a larger prospective study. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance. © 2015 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.

Transcriptional diversity of long-term glioblastoma survivors.

Science.gov (United States)

Gerber, Naamit K; Goenka, Anuj; Turcan, Sevin; Reyngold, Marsha; Makarov, Vladimir; Kannan, Kasthuri; Beal, Kathryn; Omuro, Antonio; Yamada, Yoshiya; Gutin, Phillip; Brennan, Cameron W; Huse, Jason T; Chan, Timothy A

2014-09-01

Glioblastoma (GBM) is a highly aggressive type of glioma with poor prognosis. However, a small number of patients live much longer than the median survival. A better understanding of these long-term survivors (LTSs) may provide important insight into the biology of GBM. We identified 7 patients with GBM, treated at Memorial Sloan-Kettering Cancer Center (MSKCC), with survival >48 months. We characterized the transcriptome of each patient and determined rates of MGMT promoter methylation and IDH1 and IDH2 mutational status. We identified LTSs in 2 independent cohorts (The Cancer Genome Atlas [TCGA] and NCI Repository for Molecular Brain Neoplasia Data [REMBRANDT]) and analyzed the transcriptomal characteristics of these LTSs. The median overall survival of our cohort was 62.5 months. LTSs were distributed between the proneural (n = 2), neural (n = 2), classical (n = 2), and mesenchymal (n = 1) subtypes. Similarly, LTS in the TCGA and REMBRANDT cohorts demonstrated diverse transcriptomal subclassification identities. The majority of the MSKCC LTSs (71%) were found to have methylation of the MGMT promoter. None of the patients had an IDH1 or IDH2 mutation, and IDH mutation occurred in a minority of the TCGA LTSs as well. A set of 60 genes was found to be differentially expressed in the MSKCC and TCGA LTSs. While IDH mutant proneural tumors impart a better prognosis in the short-term, survival beyond 4 years does not require IDH mutation and is not dictated by a single transcriptional subclass. In contrast, MGMT methylation continues to have strong prognostic value for survival beyond 4 years. These findings have substantial impact for understanding GBM biology and progression. © The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

The Data Release of the Sloan Digital Sky Survey-II Supernova Survey

DEFF Research Database (Denmark)

Sako, Masao; Bassett, Bruce; C. Becker, Andrew

2014-01-01

This paper describes the data release of the Sloan Digital Sky Survey-II (SDSS-II) Supernova Survey conducted between 2005 and 2007. Light curves, spectra, classifications, and ancillary data are presented for 10,258 variable and transient sources discovered through repeat ugriz imaging of SDSS S...

The Sloan Digital Sky Survey: Status and prospects

Energy Technology Data Exchange (ETDEWEB)

Loveday, J.; SDSS Collaboration

1996-05-01

The Sloan Digital Sky Survey (SDSS) is a project to definitively map {pi} steradians of the local Universe. An array of CCD detectors used in drift-scan mode will digitally image the sky in five passbands to a limiting magnitude of r{prime} {approximately} 23. Selected from the imaging survey, 10{sup 6} galaxies and 10{sup 5} quasars will be observed spectroscopically. I describe the current status of the survey, which is due to begin observations early in 1997, and its prospects for constraining models for dark matter in the Universe. 8 refs., 7 figs.

The Sloan-C Pillars: Towards a Balanced Approach to Measuring Organizational Learning

Science.gov (United States)

Yeo, Kee Meng; Mayadas, A. Frank

2010-01-01

The Sloan Pillars have set the standard for university-wide online learning program assessment for more than a dozen years. In this paper, the authors propose the extension of the Pillars to corporate e-learning, offering an alternative to traditional enterprise learning assessments. Claiming that conventional methods stress individual courses or…

World gynecologic oncology publications and the Turkish contribution to the literature between 2000 and 2007.

Science.gov (United States)

Dursun, Polat; Gultekin, Murat; Ayhan, Ali

2011-01-01

To investigate the number of publications and the contribution from top-ranking countries, institutions, and authors in 3 gynecologic oncology journals (Gynecologic Oncology [GO], International Journal of Gynecological Cancer [IJGC], and European Journal of Gynaecological Oncology [EJGO]),as well as the degree of Turkish contribution between 2000 and 2007. Articles published between 2000 and 2007 in 3 gynecologic oncology journals indexed by the Science Citation Index were accessed via the ISI-Thomson website. Additionally, PubMed, Sciencedirect, and Blackwell-Synergy databases were used to identify the originating countries and institutions of the published articles. The types of articles, originating countries, and names of the institutions and authors were determined. Furthermore, the number of articles affiliated with Turkish institutions and the publication year were also determined. We located 6,851 articles published in the 3 journals. During this period 36.1%, 7.7%, 7.2%, 5.8% and 4.8% of the papers originated from the USA, Japan, Italy, Turkey, and England, respectively. The 5 most productive institutions were the University of Texas, Memorial Sloan-Kettering Cancer Center, Roswell Park Cancer Institute, University of Alabama, and University of Athens. The 5 most productive authors were Markman (USA), Chi (USA), Ayhan (Turkey), Barakat (USA), and Vergote (Belgium), respectively. In all, 36.1% of the papers originated from the USA, while 44% originated from 17 European countries. The USA was the first-ranked country of origin in GO and IJGC, while Turkey was the first-ranked country of origin in EJGO. Overall, 399 (5.8%) papers originated from Turkish institutions. Most of the gynecologic oncology publications originated from the USA and Western European countries, where gynecologic oncology training is available and surgical and research traditions are well established. On the other hand, Turkish researchers made an important contribution to gynecologic

Contemporary computational mathematics a celebration of the 80th birthday of Ian Sloan

CERN Document Server

Kuo, Frances; Woźniakowski, Henryk

2018-01-01

This book is a tribute to Professor Ian Hugh Sloan on the occasion of his 80th birthday. It consists of nearly 60 articles written by international leaders in a diverse range of areas in contemporary computational mathematics. These papers highlight the impact and many achievements of Professor Sloan in his distinguished academic career. The book also presents state of the art knowledge in many computational fields such as quasi-Monte Carlo and Monte Carlo methods for multivariate integration, multi-level methods, finite element methods, uncertainty quantification, spherical designs and integration on the sphere, approximation and interpolation of multivariate functions, oscillatory integrals, and in general in information-based complexity and tractability, as well as in a range of other topics. The book also tells the life story of the renowned mathematician, family man, colleague and friend, who has been an inspiration to many of us. The reader may especially enjoy the story from the perspective of his fami...

Predicting the risk of perioperative transfusion for patients undergoing elective hepatectomy.

Science.gov (United States)

Sima, Camelia S; Jarnagin, William R; Fong, Yuman; Elkin, Elena; Fischer, Mary; Wuest, David; D'Angelica, Michael; DeMatteo, Ronald P; Blumgart, Leslie H; Gönen, Mithat

2009-12-01

To develop 2 instruments that predict the probability of perioperative red blood cell transfusion in patients undergoing elective liver resection for primary and secondary tumors. Hepatic resection is the most effective treatment for several benign and malign conditions, but may be accompanied by substantial blood loss and the need for perioperative transfusions. While blood conservation strategies such as autologous blood donation, acute normovolemic hemodilution, or cell saver systems are available, they are economically efficient only if directed toward patients with a high risk of transfusion. Using preoperative data from 1204 consecutive patients who underwent liver resection between 1995 and 2000 at Memorial Sloan- Kettering Cancer Center, we modeled the probability of perioperative red blood cell transfusion. We used the resulting model, validated on an independent dataset (n = 555 patients), to develop 2 prediction instruments, a nomogram and a transfusion score, which can be easily implemented into clinical practice. The planned number of liver segments resected, concomitant extrahepatic organ resection, a diagnosis of primary liver malignancy, as well as preoperative hemoglobin and platelets levels predicted the probability of perioperative red blood cell transfusion. The predictions of the model appeared accurate and with good discriminatory abilities, generating an area under the receiver operating characteristic curve of 0.71. Preoperative factors can be combined into risk profiles to predict the likelihood of transfusion during or after elective liver resection. These predictions, easy to calculate in the frame of a nomogram or of a transfusion score, can be used to identify patients who are at high risk for red cell transfusions and therefore most likely to benefit from blood conservation techniques.

Blood Transfusion Requirement and Not Preoperative Anemia Are Associated with Perioperative Complications Following Intracorporeal Robot-Assisted Radical Cystectomy.

Science.gov (United States)

Tan, Wei Shen; Lamb, Benjamin W; Khetrapal, Pramit; Tan, Mae-Yen; Tan, Melanie El; Sridhar, Ashwin; Cervi, Elizabeth; Rodney, Simon; Busuttil, Gerald; Nathan, Senthil; Hines, John; Shaw, Greg; Mohammed, Anna; Baker, Hilary; Briggs, Timothy P; Klein, Andrew; Richards, Toby; Kelly, John D

2017-02-01

To assess the prevalence of preoperative anemia and the impact of preoperative anemia and blood transfusion requirement on 30- and 90-day complications in a cohort of patients undergoing robot-assisted radical cystectomy with intracorporeal urinary diversion (iRARC). IRARC was performed on 166 patients between June 2011 and March 2016. Prospective data were collected for patient demographics, clinical and pathologic characteristics, perioperative variables, transfusion requirements, and hospital length of stay. Thirty- and 90-day complications were classified according to the modified Memorial Sloan Kettering Cancer Center Clavien-Dindo system. Preoperative anemia was common (43.4%) and greatest in patients receiving neoadjuvant chemotherapy (48.6%) (p blood transfusion (p = 0.001). Blood transfusion required in 20.4% of patients with intraoperative and postoperative blood transfusion rate was 10.2% and 13.9%, respectively. The 30-day all complication rate and 30-day major complication rate were 55.4% and 15.7%, respectively, while 90-day all complication rate and 90-day major complication rate were 65.7% and 19.3%, respectively. Intraoperative blood transfusion was not associated with increased complications, but postoperative blood transfusion requirement was independently associated with perioperative morbidity: all 30-day complications (p = 0.003), all 90-day complications (p = 0.009), and 90-day major complications (p = 0.004). The presence of preoperative anemia in patients undergoing iRARC is not associated with increased surgical risk, although preoperative anemic patients were significantly more likely to require blood transfusion. Blood transfusion requirement and specifically postoperative blood transfusion are independently associated with perioperative morbidity and are an important factor for the optimization of postoperative outcomes.

[Retrospective analysis of 47 cases with hilar cholangiocarcinoma using T-staging system].

Science.gov (United States)

Peng, Cheng-hong; Zhao, Zhi-ming; Peng, Shu-you; Liu, Ying-bin; Wu, Yü-lian; Fang, He-qing; Jiang, Xian-chuan

2005-01-01

To evaluate the clinical value of T-staging system for hilar cholangiocarcinoma which was adopted in memorial Sloan-Kettering cancer center of New York. The image data of these 47 patients were analyzed retrospectively from December 1997 to December 2002 whose data were according with our demand, and they were staged into three-stage according to the criteria of the T-staging system. The difference of respectability, ratio of tumor-free resection margin and actuarial survival rate were analyzed for different T-staging. And the coincident ratio of three different kinds of imaging methods was also analyzed. Twenty patients had T(1) tumors, twenty three had T(2) tumors and four had T(3) tumors. The resectability of the three stage was 60%, 39% and 0% respectively, and the difference was significant (P = 0.013). The likelihood of achieving tumor-free margin decreased progressively with increasing T stage (P = 0.018). The cumulative 1-year survival rates of T(1), T(2) and T(3) patients were 60%, 39% and 0% respectively, and the cumulative 3-year survival rate was 35%, 9% and 0% respectively, the survival of different stage patients differed markedly (P = 0.0103). The coincident ratio of combined using MRCP and color Doppler-ultrasonography was higher than that of combined using MRCP and B-ultrasonography or combined using CT/SCT and color Doppler-ultrasonography (P = 0.007). The T-staging system has a better value for preoperative assessment, and can be used to judge resectability and survival of hilar cholangiocarcinoma. It will be helpful to use MRCP and color Doppler-Ultrasonography combined to verdict the coverage of the tumor and the T-staging preoperatively.

Reduced prefrontal activation during working and long-term memory tasks and impaired patient-reported cognition among cancer survivors postchemotherapy compared with healthy controls.

Science.gov (United States)

Wang, Lei; Apple, Alexandra C; Schroeder, Matthew P; Ryals, Anthony J; Voss, Joel L; Gitelman, Darren; Sweet, Jerry J; Butt, Zeeshan A; Cella, David; Wagner, Lynne I

2016-01-15

Patients who receive adjuvant chemotherapy have reported cognitive impairments that may last for years after the completion of treatment. Working memory-related and long-term memory-related changes in this population are not well understood. The objective of this study was to demonstrate that cancer-related cognitive impairments are associated with the under recruitment of brain regions involved in working and recognition memory compared with controls. Oncology patients (n = 15) who were receiving adjuvant chemotherapy and had evidence of cognitive impairment according to neuropsychological testing and self-report and a group of age-matched, education group-matched, cognitively normal control participants (n = 14) underwent functional magnetic resonance imaging. During functional magnetic resonance imaging, participants performed a nonverbal n-back working memory task and a visual recognition task. On the working memory task, when 1-back and 2-back data were averaged and contrasted with 0-back data, significantly reduced activation was observed in the right dorsolateral prefrontal cortex for oncology patients versus controls. On the recognition task, oncology patients displayed decreased activity of the left-middle hippocampus compared with controls. Neuroimaging results were not associated with patient-reported cognition. Decreased recruitment of brain regions associated with the encoding of working memory and recognition memory was observed in the oncology patients compared with the control group. These results suggest that there is a reduction in neural functioning postchemotherapy and corroborate patient-reported cognitive difficulties after cancer treatment, although a direct association was not observed. Cancer 2016;122:258-268. © 2015 American Cancer Society. © 2015 American Cancer Society.

The Sloan-C Pillars and Boundary Objects As a Framework for Evaluating Blended Learning

Science.gov (United States)

Laumakis, Mark; Graham, Charles; Dziuban, Chuck

2009-01-01

The authors contend that blended learning represents a boundary object; a construct that brings together constituencies from a variety of backgrounds with each of these cohorts defining the object somewhat differently. The Sloan-C Pillars (learning effectiveness, access, cost effectiveness, student satisfaction, and faculty satisfaction) provide…

What do cancer patients mean when they complain of concentration and memory problems?

NARCIS (Netherlands)

Cull, A.; Hay, C.; Love, S. B.; Mackie, M.; Smets, E.; Stewart, M.

1996-01-01

Cognitive function items are increasingly included in quality of life measures, and complaints of concentration and memory difficulties are often reported by cancer patients. The aim of this study was to examine the factors influencing patients' level of complaint by comparing subjective reports

Attention and memory deficits in breast cancer survivors: implications for nursing practice and research.

Science.gov (United States)

Frank, Jennifer Sandson; Vance, David E; Jukkala, Angela; Meneses, Karen M

2014-10-01

Breast cancer survivors (BCSs) commonly report deficits in attention and memory, cognitive functions crucial for daily optimal functioning. Perceived deficits are reported before, during, and after adjuvant therapy and affect quality of life throughout survivorship. Deficits of attention and memory are particularly disruptive for BCSs working or attending school who report that subtle impairment diminishes their confidence and their performance at all levels of occupation. Chemotherapy and endocrine therapy contribute to attention and memory deficits, but research findings have not fully established the extent or timing of that influence. Fortunately, potential interventions for attention and memory deficits in BCSs are promising. These include cognitive remediation therapies aimed at training for specific areas of deficit, cognitive behavioral therapies aimed at developing compensatory strategies for areas of deficit, complementary therapies, and pharmacologic therapies.

Finding Clusters of Galaxies in the Sloan Digital Sky Survey using Voronoi Tessellation

International Nuclear Information System (INIS)

Rita S.J., Kim

2001-01-01

The Sloan Digital Sky Survey has obtained 450 square degrees of photometric scan data, in five bands (u', g', r', i', z'), which the authors use to identify clusters of galaxies. They illustrate how they do star-galaxy separation, and present a simple and elegant method of detecting over-densities in the galaxy distribution, using the Voronoi Tessellation

The chemotherapeutic agent paclitaxel selectively impairs learning while sparing source memory and spatial memory.

Science.gov (United States)

Smith, Alexandra E; Slivicki, Richard A; Hohmann, Andrea G; Crystal, Jonathon D

2017-03-01

Chemotherapeutic agents are widely used to treat patients with systemic cancer. The efficacy of these therapies is undermined by their adverse side-effect profiles such as cognitive deficits that have a negative impact on the quality of life of cancer survivors. Cognitive side effects occur across a variety of domains, including memory, executive function, and processing speed. Such impairments are exacerbated under cognitive challenges and a subgroup of patients experience long-term impairments. Episodic memory in rats can be examined using a source memory task. In the current study, rats received paclitaxel, a taxane-derived chemotherapeutic agent, and learning and memory functioning was examined using the source memory task. Treatment with paclitaxel did not impair spatial and episodic memory, and paclitaxel treated rats were not more susceptible to cognitive challenges. Under conditions in which memory was not impaired, paclitaxel treatment impaired learning of new rules, documenting a decreased sensitivity to changes in experimental contingencies. These findings provide new information on the nature of cancer chemotherapy-induced cognitive impairments, particularly regarding the incongruent vulnerability of episodic memory and new learning following treatment with paclitaxel. Copyright © 2016 Elsevier B.V. All rights reserved.

Dynamical Black Hole Masses of BL Lac Objects from the Sloan Digital Sky Survey

NARCIS (Netherlands)

Plotkin, Richard M.; Markoff, Sera; Trager, Scott C.; Anderson, Scott F.

2012-01-01

We measure black hole masses for 71 BL Lac objects from the Sloan Digital Sky Survey (SDSS) with redshifts out to z ∼ 0.4. We perform spectral decompositions of their nuclei from their host galaxies and measure their stellar velocity dispersions. Black hole masses are then derived from the black

Learning and memory performance in breast cancer survivors 2 to 6 years post-treatment: the role of encoding versus forgetting.

Science.gov (United States)

Root, James C; Andreotti, Charissa; Tsu, Loretta; Ellmore, Timothy M; Ahles, Tim A

2016-06-01

Our previous retrospective analysis of clinically referred breast cancer survivors' performance on learning and memory measures found a primary weakness in initial encoding of information into working memory with intact retention and recall of this same information at a delay. This suggests that survivors may misinterpret cognitive lapses as being due to forgetting when, in actuality, they were not able to properly encode this information at the time of initial exposure. Our objective in this study was to replicate and extend this pattern of performance to a research sample to increase the generalizability of this finding in a sample in which subjects were not clinically referred for cognitive issues. We contrasted learning and memory performance between breast cancer survivors on endocrine therapy 2 to 6 years post-treatment with age- and education-matched healthy controls. We then stratified lower- and higher-performing breast cancer survivors to examine specific patterns of learning and memory performance. Contrasts were generated for four aggregate visual and verbal memory variables from the California Verbal Learning Test-2 (CVLT-2) and the Brown Location Test (BLT): Single-trial Learning: Trial 1 performance, Multiple-trial Learning: Trial 5 performance, Delayed Recall: Long-delay Recall performance, and Memory Errors: False-positive errors. As predicted, breast cancer survivors' performance as a whole was significantly lower on Single-trial Learning than the healthy control group but exhibited no significant difference in Delayed Recall. In the secondary analysis contrasting lower- and higher-performing survivors on cognitive measures, the same pattern of lower Single-trial Learning performance was exhibited in both groups, with the additional finding of significantly weaker Multiple-trial Learning performance in the lower-performing breast cancer group and intact Delayed Recall performance in both groups. As with our earlier finding of weaker initial

A Survey of z>5.7 Quasars in the Sloan Digital Sky Survey IV

DEFF Research Database (Denmark)

Fan, Xiaohui; Strauss, Michael A.; Richards, Gordon T.

2005-01-01

We present the discovery of seven quasars at z>5.7, selected from ~2000 deg^2 of multicolor imaging data of the Sloan Digital Sky Survey (SDSS). The new quasars have redshifts z from 5.79 to 6.13. Five are selected as part of a complete flux-limited sample in the SDSS Northern Galactic Cap; two...

Risk for Arterial and Venous Thrombosis in Patients With Myeloproliferative Neoplasms: A Population-Based Cohort Study.

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Hultcrantz, Malin; Björkholm, Magnus; Dickman, Paul W; Landgren, Ola; Derolf, Åsa R; Kristinsson, Sigurdur Y; Andersson, Therese M L

2018-03-06

Patients with myeloproliferative neoplasms (MPNs) are reported to be at increased risk for thrombotic events. However, no population-based study has estimated this excess risk compared with matched control participants. To assess risk for arterial and venous thrombosis in patients with MPNs compared with matched control participants. Matched cohort study. Population-based setting in Sweden from 1987 to 2009, with follow-up to 2010. 9429 patients with MPNs and 35 820 matched control participants. The primary outcomes were rates of arterial and venous thrombosis. Flexible parametric models were used to calculate hazard ratios (HRs) and cumulative incidence with 95% CIs. The HRs for arterial thrombosis among patients with MPNs compared with control participants at 3 months, 1 year, and 5 years were 3.0 (95% CI, 2.7 to 3.4), 2.0 (CI, 1.8 to 2.2), and 1.5 (CI, 1.4 to 1.6), respectively. The corresponding HRs for venous thrombosis were 9.7 (CI, 7.8 to 12.0), 4.7 (CI, 4.0 to 5.4), and 3.2 (CI, 2.9 to 3.6). The rate was significantly elevated across all age groups and was similar among MPN subtypes. The 5-year cumulative incidence of thrombosis in patients with MPNs showed an initial rapid increase followed by gentler increases during follow-up. The HR for venous thrombosis decreased during more recent calendar periods. No information on individual laboratory results or treatment. Patients with MPNs across all age groups have a significantly increased rate of arterial and venous thrombosis compared with matched control participants, with the highest rates at and shortly after diagnosis. Decreases in the rate of venous thrombosis over time likely reflect advances in clinical management. The Cancer Research Foundations of Radiumhemmet, Blodcancerfonden, the Swedish Research Council, the regional agreement on medical training and clinical research between Stockholm County Council and Karolinska Institutet, the Adolf H. Lundin Charitable Foundation, and Memorial Sloan

Intensity-modulated radiotherapy -the State of the Art

International Nuclear Information System (INIS)

Ling, C.

2002-01-01

Full text: In the last two decades of the last century, the development of three-dimensional conformal radiotherapy (3D-CRT) has substantially reduces the volume of critical organs irradiated to high doses, and has permitted the increase of tumor dose without concomitant increase in normal tissue complication. At Memorial Sloan Kettering Cancer Center, a clinical trial in cancer of the prostate has accrued >1600 patient and the prescription dose has been escalated to 81 Gy with 3D-CRT, and to 86.4 Gy using intensity modulated radiotherapy (IMRT), with promising results. 3D-CRT and IMRT involves the delineation of target and non-target structures from patient-specific 3D image data-sets (primarily CT, sometimes supplemented with MRI, PET etc.), the calculation and display of 3D dose distributions, the analysis and evaluation of structure-specific dose-volume data (DVH-dose volume histogram), radiation delivery with computer-controlled multileaf collimators (MLC), and treatment verification with electronic portal images. However, the dose distribution conformality achieved with 3D-CRT can be further improved by the use of computer-optimized IMRT. In addition, the treatment design phase of 3D-CRT involves several iterative steps and can be time-consuming, particularly when the anatomical geometry is complex. Thus, IMRT is an incremental advance from 3D-CRT with two key enhancements: 1) computerized iterative treatment plan optimization, and 2) the use of intensity-modulated radiation beams. To deliver the IM beams, one efficacious approach is to use MLC in the dynamic mode, using the so-called sliding-window technique, i.e. the leaves of the MLC are in motion while the radiation is being delivered. Since 1995, we have treated over 1500 patients with IMRT. This discussion shall describe the physical aspects of IMRT, emphasizing those features and benefits unique to this approach. Pertinent clinical results will also be briefly presented

Value Frameworks in Oncology: Comparative Analysis and Implications to the Pharmaceutical Industry.

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Slomiany, Mark; Madhavan, Priya; Kuehn, Michael; Richardson, Sasha

2017-07-01

As the cost of oncology care continues to rise, composite value models that variably capture the diverse concerns of patients, physicians, payers, policymakers, and the pharmaceutical industry have begun to take shape. To review the capabilities and limitations of 5 of the most notable value frameworks in oncology that have emerged in recent years and to compare their relative value and application among the intended stakeholders. We compared the methodology of the American Society of Clinical Oncology (ASCO) Value Framework (version 2.0), the National Comprehensive Cancer Network Evidence Blocks, Memorial Sloan Kettering Cancer Center DrugAbacus, the Institute for Clinical and Economic Review Value Assessment Framework, and the European Society for Medical Oncology Magnitude of Clinical Benefit Scale, using a side-by-side comparative approach in terms of the input, scoring methodology, and output of each framework. In addition, we gleaned stakeholder insights about these frameworks and their potential real-world applications through dialogues with physicians and payers, as well as through secondary research and an aggregate analysis of previously published survey results. The analysis identified several framework-specific themes in their respective focus on clinical trial elements, breadth of evidence, evidence weighting, scoring methodology, and value to stakeholders. Our dialogues with physicians and our aggregate analysis of previous surveys revealed a varying level of awareness of, and use of, each of the value frameworks in clinical practice. For example, although the ASCO Value Framework appears nascent in clinical practice, physicians believe that the frameworks will be more useful in practice in the future as they become more established and as their outputs are more widely accepted. Along with patients and payers, who bear the burden of treatment costs, physicians and policymakers have waded into the discussion of defining value in oncology care, as well

Growth patterns of survivors of retinoblastoma treated with ophthalmic artery chemosurgery.

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Sruti S Akella

Full Text Available Although studies from pediatric cancers (largely acute lymphoblastic leukemia have shown that patients undergoing systemic chemotherapy may experience decreased growth velocity during the treatment phase, no such data exist for retinoblastoma patients treated with systemic chemotherapy or ophthalmic artery chemosurgery (OAC. The purpose of this study is to report growth patterns of our retinoblastoma (Rb population who were treated with OAC in a retrospective, single center (Memorial Sloan Kettering Cancer Center review of 341 patients treated between 2006 and 2016. Children who only received OAC were classified as naive; those who were treated initially with systemic chemotherapy and subsequently presented to our center for OAC were termed secondary; and a small group of patients who received single-agent systemic chemotherapy prior to OAC were labeled bridge. For all patients, height and weight were recorded at monthly intervals during OAC (short-term and then annually during a follow-up period (long-term up to 3 years after treatment. Excluded from this study were children who received external radiation therapy and those with genetic syndromes, which are independently associated with growth derangements. During OAC, there was no significant difference in growth velocity between the naïve and secondary groups. In either group, number of treatments also did not affect growth rate. Three years after the end of OAC, naïve patients were in the 68th percentile by height (95% CI 61.30, 74.63 compared to secondary patients in the 61st percentile (95% CI 51.1, 71.47. Both groups were in the same weight percentiles during the first two years of follow-up but at the three-year follow-up period, naïve patients were in the 63rd percentile (95% CI 57.4, 69.4 and secondary patients were in the 60th percentile (95% CI 50.4, 69.7. OAC for retinoblastoma does not appear to impact short-term growth velocity, weight gain during the treatment period or after

The Working Memory and Dorsolateral Prefrontal-Hippocampal Functional Connectivity Changes in Long-Term Survival Breast Cancer Patients Treated with Tamoxifen

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Chen, Xingui; Tao, Longxiang; Li, Jingjing; Wu, Jiaonan; Zhu, Chunyan; Yu, Fengqiong; Zhang, Lei; Zhang, Jingjie; Qiu, Bensheng; Yu, Yongqiang; He, Xiaoxuan

2017-01-01

Abstract Background: Tamoxifen is the most widely used drug for treating patients with estrogen receptor-sensitive breast cancer. There is evidence that breast cancer patients treated with tamoxifen exhibit cognitive dysfunction. However, the underlying neural mechanism remains unclear. The present study aimed to investigate the neural mechanisms underlying working memory deficits in combination with functional connectivity changes in premenopausal women with breast cancer who received long-term tamoxifen treatment. Methods: A total of 31 premenopausal women with breast cancer who received tamoxifen and 32 matched healthy control participants were included. The participants completed n-back tasks and underwent resting-state functional magnetic resonance imaging, which measure working memory performance and brain functional connectivity, respectively. A seed-based functional connectivity analysis within the whole brain was conducted, for which the dorsolateral prefrontal cortex was chosen as the seed region. Results: Our results indicated that the tamoxifen group had significant deficits in working memory and general executive function performance and significantly lower functional connectivity of the right dorsolateral prefrontal cortex with the right hippocampus compared with the healthy controls. There were no significant changes in functional connectivity in the left dorsolateral prefrontal cortex within the whole brain between the tamoxifen group and healthy controls. Moreover, significant correlations were found in the tamoxifen group between the functional connectivity strength of the dorsolateral prefrontal cortex with the right hippocampus and decreased working memory performance. Conclusion: This study demonstrates that the prefrontal cortex and hippocampus may be affected by tamoxifen treatment, supporting an antagonistic role of tamoxifen in the long-term treatment of breast cancer patients. PMID:28177081

Searching for white dwarfs candidates in Sloan Digital Sky Survey Data

International Nuclear Information System (INIS)

Nalezyty, Miroslaw; Majczyna, Agnieszka; Ciechanowska, Anna; Madej, Jerzy

2009-01-01

Large amount of observational spectroscopic data are recently available from different observational projects, like Sloan Digital Sky Survey. It's become more urgent to identify white dwarfs stars based on data itself i.e. without modelling white dwarf atmospheres. In particular, existing methods of white dwarfs identification presented in Kleinman et al. (2004) and in Eisenstein et al. (2006) did not allow to find all the white dwarfs in examined data. We intend to test various criteria of searching for white dwarf candidates, based on photometric and spectral features.

Family focused grief therapy: The therapy of choice in palliative care

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Klikovac Tamara

2017-01-01

Full Text Available Palliative care refers to offering physical, psychosocial and spiritual care to patients who are suffering from life threatening diseases. It also includes providing psychological support for family members and other close relations during the period of illness (anticipatory grief and in the period of bereavement and mourning after the patient's death. The choice of therapy during the process of bereavement and mourning is Family Focused Grief Therapy (FFGT. FFGT is a brief, focused and time-limited psychotherapeutic model of intervention belonging to family psychotherapy which is specified for the families that face a life threatening disease of a family member. FFGT, with some modifications, can be applied in work with the families who are facing a terminal illness of younger family members - a child or an adolescent. FFGT typically comprises of 7 to 9 sessions lasting for 90 minutes, which are arranged flexibly across 9 to 18 months, depending on the needs of each family individually. It is important to emphasize that the frequency and number of sessions in each phase depend on the specific features and needs of each particular family. The intervention aim of FFGT is to prevent the complications of bereavement by enhancing the functioning of the family, through exploration of its cohesion, communications (of thoughts and feelings, and handling of conflict. The story of illness and the related grief is shared in the process. The creator of this model is Dr David Kissane, a psychiatrist and a family psychotherapist from Melbourne, Australia, who also worked at the Memorial Sloan Kettering Cancer Centre in New York. The main aims of this article are, on the one hand, to introduce this very useful model of the family therapy to the professional community in Serbia and, on the other, to introduce a conceptual and practical frame of palliative care.

Safety and treatment outcomes of first-line pazopanib in renal cell carcinoma: A prospective observational study in a single Malaysia tertiary hospital

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Azmi Nor Mohd Farez Ahmat

2017-12-01

Full Text Available Introduction: Pazopanib is the standard of care for metastatic renal cell carcinoma (mRCC. Previous studies on this indication were limited to patients who were selected on the basis of a fairly preserved performance status and normal organ function. Thus, the clinical trial population may not be representative of all patients seen in real-world practice. Based on these considerations, this prospective single-centre observational study was designed to evaluate the treatment outcomes and safety profile of pazopanib in Malaysian population. Patients and methods: Patients prescribed with pazopanib between June 2015 and June 2017 were recruited and followed up for 2-years or till death whichever comes first. Progression-free survival (PFS and overall survival (OS were evaluated. Multivariate and survival analysis were performed. Results: Twenty-seven patients were treated with pazopanib where 89% had clear cell histology.  Sixteen patients (59% were intermediate risk and 41% were poor risk based on Memorial Sloan Kettering Cancer Center (MSKCC criteria. All patients experienced at least one adverse event. The most common were cutaneous toxicity (92% followed by proteinuria, hypertension, diarrhoea and mucositis. Treatment interruption was needed in 15 patients. The median PFS and OS were 9.57 months and 15.5 months, respectively. In multivariate analysis, MSKCC risk score demonstrates strong predictive treatment outcome. The median PFS was 14.5 months in intermediate risk and 3.96 months in poor risk (OR: 0.2, p<0.001. However, the median OS is still immature to be reported since 63% of intermediate risk group is still alive at 2-years follow-up. Conclusion: In mRCC patients, treatment with pazopanib was effective in patients with intermediate risk group. In terms of safety, patient tolerated pazopanib quite well with mostly experienced grade 1 to 2 adverse events.

Outcomes and Prognostic Variables in Adenoid Cystic Carcinoma of the Head and Neck: A Recent Experience

International Nuclear Information System (INIS)

Gomez, Daniel R.; Hoppe, Bradford S.; Wolden, Suzanne L.; Zhung, Joanne E.; Patel, Snehal G.; Kraus, Dennis H.; Shah, Jatin P.; Ghossein, Ronald A.; Lee, Nancy Y.

2008-01-01

Purpose: To analyze the recent experience of patients with adenoid cystic carcinoma treated with radiation therapy at Memorial Sloan-Kettering Cancer Center. Methods and Materials: From 1990 to 2004, a total of 59 patients with a diagnosis of primary adenoid cystic carcinoma of the head and neck received radiation therapy at our institution. The subsite distribution was oral cavity, 28% (n = 17); paranasal sinuses, 22% (n = 13); parotid, 14% (n = 8); submandibular, 14% (n = 8); oropharynx, 10% (n = 6); sublingual, 3% (n = 2); nasopharynx, 3% (n = 2); and other, 5% (n = 3). T Stage distribution was T1, 34% (n = 20); T2, 19% (n = 11); T3, 14% (n = 8); and T4, 34% (n = 20). Twenty-nine percent of patients (n = 17) were treated with intensity-modulated radiation therapy; 25% (n =15), with three-dimensional conformal therapy, and the remainder, with conventional techniques. Ninety percent (n = 53) of patients received treatment including the base of skull. Results: Median follow-up for surviving patients was 5.9 years. Five-year and 10-year rates of local control and distant metastases-free survival were 91%/81% and 81%/49%, respectively. Five-year and 10-year rates of disease-free and overall survival were 76%/40% and 87%/65%, respectively. On univariate analysis, stage T4 (p = 0.004) and gross/clinical nerve involvement (p = 0.002) were associated with decreased progression free survival, whereas stage T4 and lymph node involvement were associated with decreased overall survival (p = 0.046 and p < 0.001, respectively). Conclusions: Radiation therapy in combination with surgery produces excellent rates of local control, although distant metastases account for a high proportion of failures. Routine treatment to the base of skull reduces the significance of histologic perineural invasion, but major nerve involvement remains an adverse prognostic factor

Treatment of primary unresectable carcinoma of the pancreas with I-125 implantation

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Peretz, T.; Nori, D.; Hilaris, B.; Manolatos, S.; Linares, L.; Harrison, L.; Anderson, L.L.; Fuks, Z.; Brennan, M.F. (Memorial Sloan-Kettering Cancer Center, New York, NY (USA))

1989-11-01

Between January 1 1974 and October 31 1987, 98 patients with biopsy proven unresectable adenocarcinoma of the pancreas were treated with I-125 implants during laparotomy. Presenting symptoms were pain, jaundice, and weight loss. All patients underwent laparotomy and surgical staging. Thirty patients had T1NoMo disease, 47 patients had T2-3NoMo disease, and 21 patients had significant regional lymph node involvement (T1-3N1Mo). The surgical procedure performed was biopsy only (16 patients), gastric bypass, biliary bypass, and partial or total pancreatectomy with incomplete resection. The total activity and the number of seeds used were determined from the Memorial Sloan Kettering Cancer Center (MSKCC) nomogram. Stereoshift localization X ray films were taken 3-6 days after operation. The mean activity, minimal peripheral dose (MPD), and volume of the implants were 35 mCi, 13,660 cGy, and 53 cm3, respectively. In addition, 27 patients received postoperative external irradiation and 27 patients received chemotherapy. Postoperative complications were observed in 19 patients. These included post-operative death (1 patient), biliary fistula (4), intraabdominal abscess (4), GI bleeding (3), gastric or small bowel obstruction (6), sepsis (5), and deep vein thrombophlebitis (4). Pain relief was obtained in 37/57 patients (65%) presenting with pain. A multivariate analysis showed that four factors significantly affected survival: T stage, N stage, administration of chemotherapy, and more than 30% reduction in the size of the implant on follow-up films. The median survival for the entire group was 7 months. A subgroup of patients with T1No stage disease who received chemotherapy survived 18.5 months. The indications for I-125 seed implantation in unresectable carcinoma of the pancreas are discussed.

Treatment of primary unresectable carcinoma of the pancreas with I-125 implantation

International Nuclear Information System (INIS)

Peretz, T.; Nori, D.; Hilaris, B.; Manolatos, S.; Linares, L.; Harrison, L.; Anderson, L.L.; Fuks, Z.; Brennan, M.F.

1989-01-01

Between January 1 1974 and October 31 1987, 98 patients with biopsy proven unresectable adenocarcinoma of the pancreas were treated with I-125 implants during laparotomy. Presenting symptoms were pain, jaundice, and weight loss. All patients underwent laparotomy and surgical staging. Thirty patients had T1NoMo disease, 47 patients had T2-3NoMo disease, and 21 patients had significant regional lymph node involvement (T1-3N1Mo). The surgical procedure performed was biopsy only (16 patients), gastric bypass, biliary bypass, and partial or total pancreatectomy with incomplete resection. The total activity and the number of seeds used were determined from the Memorial Sloan Kettering Cancer Center (MSKCC) nomogram. Stereoshift localization X ray films were taken 3-6 days after operation. The mean activity, minimal peripheral dose (MPD), and volume of the implants were 35 mCi, 13,660 cGy, and 53 cm3, respectively. In addition, 27 patients received postoperative external irradiation and 27 patients received chemotherapy. Postoperative complications were observed in 19 patients. These included post-operative death (1 patient), biliary fistula (4), intraabdominal abscess (4), GI bleeding (3), gastric or small bowel obstruction (6), sepsis (5), and deep vein thrombophlebitis (4). Pain relief was obtained in 37/57 patients (65%) presenting with pain. A multivariate analysis showed that four factors significantly affected survival: T stage, N stage, administration of chemotherapy, and more than 30% reduction in the size of the implant on follow-up films. The median survival for the entire group was 7 months. A subgroup of patients with T1No stage disease who received chemotherapy survived 18.5 months. The indications for I-125 seed implantation in unresectable carcinoma of the pancreas are discussed

Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation.

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Weber, Daniela; Jenq, Robert R; Peled, Jonathan U; Taur, Ying; Hiergeist, Andreas; Koestler, Josef; Dettmer, Katja; Weber, Markus; Wolff, Daniel; Hahn, Joachim; Pamer, Eric G; Herr, Wolfgang; Gessner, André; Oefner, Peter J; van den Brink, Marcel R M; Holler, Ernst

2017-05-01

In allogeneic stem cell transplantation (ASCT), systemic broad-spectrum antibiotics are frequently used for treatment of infectious complications, but their effect on microbiota composition is still poorly understood. This retrospective analysis of 621 patients who underwent ASCT at the University Medical Center of Regensburg and Memorial Sloan Kettering Cancer Center in New York assessed the impact of timing of peritransplant antibiotic treatment on intestinal microbiota composition as well as transplant-related mortality (TRM) and overall survival. Early exposure to antibiotics was associated with lower urinary 3-indoxyl sulfate levels (P antibiotic treatment, which was particularly significant (P = .005) for Clostridium cluster XIVa in the Regensburg group. Earlier antibiotic treatment before ASCT was further associated with a higher TRM (34%, 79/236) compared with post-ASCT (21%, 62/297, P = .001) or no antibiotics (7%, 6/88, P antibiotic treatment was the dominant independent risk factor for TRM (HR, 2.0; P ≤ .001) in multivariate analysis besides increase age (HR, 2.15; P = .004), reduced Karnofsky performance status (HR, 1.47; P = .03), and female donor-male recipient sex combination (HR, 1.56; P = .02) A competing risk analysis revealed the independent effect of early initiation of antibiotics on graft-versus-host disease-related TRM (P = .004) in contrast to infection-related TRM and relapse (not significant). The poor outcome associated with early administration of antibiotic therapy that is active against commensal organisms, and specifically the possibly protective Clostridiales, calls for the use of Clostridiales-sparing antibiotics and rapid restoration of microbiota diversity after cessation of antibiotic treatment. Copyright © 2017 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

Management and outcome of stage 3 neuroblastoma

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Modak, Shakeel; Kushner, Brian H.; LaQuaglia, Michael P.; Kramer, Kim; Cheung, Nai-Kong V.

2013-01-01

Purpose The management of patients with International Neuroblastoma Staging System (INSS) stage 3 neuroblastoma (NB) is not consistent worldwide. We describe a single centre approach at Memorial Sloan-Kettering Cancer Centre (MSKCC) from 1991 to 2007 that minimizes therapy except for those patients with MYCN-amplified NB. Methods In this retrospective analysis of 69 patients, tumour MYCN was not amplified in 53 and amplified in 16. Event-free survival (EFS) and overall survival (OS) were determined by Kaplan–Meier analysis. Results Fourteen patients with non-MYCN-amplified tumours were treated with surgery alone (group A) and the remaining 39 (group B) with surgery following chemotherapy that was initiated and administered at non-MSKCC institutions. Chemotherapy was discontinued after surgery in 38/39 of the latter. The 10-year EFS and OS for all patients with MYCN-non-amplified NB were 74.9 ± 16.9% and 92.6 ± 5.5%, respectively. There was no difference in OS between groups A and B (p = 0.2; 10-year OS for groups A and B was 84.6 ± 14% and 97.1 ± 2.9%, respectively). Patients with MYCN-amplified disease (group C) underwent dose-intensive induction, tumour resection and local radiotherapy: 13 achieved complete or very good partial remission, and 10 received myeloablative chemotherapy. 11/16 patients also received 3F8-based immunotherapy: 10 remain free of disease. The 10-year EFS and OS for patients with MYCN-amplified neuroblastoma treated with immunotherapy were both 90.9 ± 8.7%. Conclusion Patients with MYCN-non-amplified stage 3 NB can be successfully treated with surgery without the need for radiotherapy or continuation of chemotherapy. Combination of dose-intensive chemotherapy, surgery, radiotherapy and immunotherapy was associated with a favourable outcome for most patients with MYCN-amplified stage 3 NB. PMID:18996003

Treatment and outcome of adult-onset neuroblastoma.

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Suzuki, Maya; Kushner, Brian H; Kramer, Kim; Basu, Ellen M; Roberts, Stephen S; Hammond, William J; LaQuaglia, Michael P; Wolden, Suzanne L; Cheung, Nai-Kong V; Modak, Shakeel

2018-03-25

Adult-onset neuroblastoma is rare and little is known about its biology and clinical course. There is no established therapy for adult-onset neuroblastoma. Anti-GD2 immunotherapy is now standard therapy in children with high-risk neuroblastoma; however, its use has not been reported in adults. Forty-four adults (18-71 years old) diagnosed with neuroblastoma between 1979 and 2015 were treated at Memorial Sloan Kettering Cancer Center. Five, 1, 5 and 33 patients had INSS stage 1, 2, 3 and 4 diseases, respectively. Genetic abnormalities included somatic ATRX (58%) and ALK mutations (42%) but not MYCN-amplification. In the 11 patients with locoregional disease, 10-year progression-free (PFS) and overall survival (OS) was 35.4 ± 16.1% and 61.4 ± 15.3%, respectively. Among 33 adults with stage 4 neuroblastoma, 7 (21%) achieved complete response (CR) after induction chemotherapy and/or surgery. Seven patients with primary refractory neuroblastoma (all with osteomedullary but no soft tissue disease) received anti-GD2 antibodies, mouse or humanized 3F8. Antibody-related adverse events were similar to those in children, response rate being 71.4%. In patients with stage 4 disease at diagnosis, 5-year PFS was 9.7± 5.3% and most patients who were alive with disease at 5 years died of neuroblastoma over the next 5 years, 10-year OS being only 19.0 ± 8.2%. Patients who achieved CR after induction had superior PFS and OS (p = 0.006, p = 0.031, respectively). Adult-onset neuroblastoma appeared to have different biology from pediatric or adolescent NB, and poorer outcome. Complete disease control appeared to improve long-term survival. Anti-GD2 immunotherapy was well tolerated and might be beneficial. © 2018 UICC.

Involved field (IF) irradiation with or without chemotherapy in the management of children with Hodgkin's disease

International Nuclear Information System (INIS)

Jereb, B.; Tan, C.; Bretsky, S.; He, S.Q.; Exelby, P.

1984-01-01

The present policy at Memorial Sloan Kettering Cancer Center (MSKCC) of treating children with Hodgkin's disease [HD] is as follows: involved field (IF) irradiation only (3,600 rad) for Stages IA and IIA; IF irradiation (2,400 or 2,000 rad) combined with multidrug chemotherapy (MDP) protocol for all other stages. A somewhat higher recurrence rate is accepted for Stages IA and IIA in view of the good salvage rate for these recurrences and in view of side effects of more aggressive types of radiation treatment. One hundred forty-two patients with HD, 2-19 years of age, were treated at MSKCC between 1970 and 1981; 98 of these were treated according to the present policy (SP group), and 44 (NP group) were treated differently. All SP patients underwent staging laparotomy. The follow-up time was 12 to 146 months with a median of 65 months; two patients were lost to follow-up. For the SP group, all stages, 10-year disease-free survival is 77%, and 10-year survival is 93%. By comparison, in the NP group 10-year disease-free survival is 64%, and 10-year survival is 80%. The disease-free survival of SP patients in Stages IA and IIA treated with IF radiation alone is 72%, and survival is 95%. The disease-free survival of SP patients in advanced stages treated with combined radiation and chemotherapy is 87%; the salvage rate of recurrent disease in these stages is poor. The survival was apparently better in the SP group as compared to the NP group. All 6 patients of the SP group who died had a nodular sclerosing type of HD. None of the patients in the SP group have developed secondary malignancies, and no severe bone growth retardations or late effects to other organs were observed

Rhabdomyosarcoma in childhood

International Nuclear Information System (INIS)

Gadner, H.

1984-01-01

In spite of an excellent improvement of treatment strategies many questions about the best therapeutic approach in rhabdomyosarcoma remain open. The rare incidence (4,5 per million children and year), the biological heterogeneity, the different localisations and stages of disease still remain a challenge for the interdisciplinary cooperation in paediatric oncology. The optimum treatment consists of a qualified combination of chemo- and radiotherapy as well as surgical intervention. The importance of each modality is to be defined in every individual case. Only with such an approach severe mutilations can be avoided and a better chance of survival offered. A national study for rhabdomyosarcoma of the Austrian Paediatric Oncology Group is presented, which has been established in close collaboration with the paediatric onologists of West-Germany. The study protocol since January 1982 is still in use. Therapeutic strategies of the Intergroup Rhabdomyosarcoma Study Group were taken into consideration. The chemotherapy essentially consists of a modified T9- and T11-protocol (Memorial Sloan Kettering Cancer Center, New York) including newer drugs like cisplatin and VP 16 -213. The surgical intervention is recommended as primary resection only when multilations can be avoided (otherwise a biopsy is proposed). The secondary and definitive resection or biopsy is provided for the time period after completion of 16 weeks of chemotherapy. The addition of radiotherapy after the second look operation promises the maximum of curative effect. The following chemotherapy is planned for further 16 or 36 weeks according to the stage of disease. Because of the rather small number of patients and because of the necessity of a close collaboration between surgeons, urologists, radiotherapists and paediatricians it is recommended to transfer the patient to a center of paediatric oncology. (Author)

THE SLOAN DIGITAL SKY SURVEY CO-ADD: A GALAXY PHOTOMETRIC REDSHIFT CATALOG

International Nuclear Information System (INIS)

Reis, Ribamar R. R.; Soares-Santos, Marcelle; Annis, James; Dodelson, Scott; Hao Jiangang; Johnston, David; Kubo, Jeffrey; Lin Huan; Seo, Hee-Jong; Simet, Melanie

2012-01-01

We present and describe a catalog of galaxy photometric redshifts (photo-z) for the Sloan Digital Sky Survey (SDSS) Co-add Data. We use the artificial neural network (ANN) technique to calculate the photo-z and the nearest neighbor error method to estimate photo-z errors for ∼13 million objects classified as galaxies in the co-add with r 68 = 0.031. After presenting our results and quality tests, we provide a short guide for users accessing the public data.

Topology Analysis of the Sloan Digital Sky Survey. I. Scale and Luminosity Dependence

Science.gov (United States)

Park, Changbom; Choi, Yun-Young; Vogeley, Michael S.; Gott, J. Richard, III; Kim, Juhan; Hikage, Chiaki; Matsubara, Takahiko; Park, Myeong-Gu; Suto, Yasushi; Weinberg, David H.; SDSS Collaboration

2005-11-01

We measure the topology of volume-limited galaxy samples selected from a parent sample of 314,050 galaxies in the Sloan Digital Sky Survey (SDSS), which is now complete enough to describe the fully three-dimensional topology and its dependence on galaxy properties. We compare the observed genus statistic G(νf) to predictions for a Gaussian random field and to the genus measured for mock surveys constructed from new large-volume simulations of the ΛCDM cosmology. In this analysis we carefully examine the dependence of the observed genus statistic on the Gaussian smoothing scale RG from 3.5 to 11 h-1 Mpc and on the luminosity of galaxies over the range -22.50meatball'' (i.e., cluster dominated) topology, while faint galaxies show a positive shift toward a ``bubble'' (i.e., void dominated) topology. The transition from negative to positive shift occurs approximately at the characteristic absolute magnitude Mr*=-20.4. Even in this analysis of the largest galaxy sample to date, we detect the influence of individual large-scale structures, as the shift parameter Δν and cluster multiplicity AC reflect (at ~3 σ) the presence of the Sloan Great Wall and an X-shaped structure that runs for several hundred megaparsecs across the survey volume.

Memories of Parent Behaviors and Adult Attachment in Childhood Cancer Survivors.

Science.gov (United States)

Lehmann, Vicky; Hagedoorn, Mariët; Gerhardt, Cynthia A; Keim, Madelaine C; Guthrie, Lory; Sanderman, Robbert; Tuinman, Marrit A

2017-03-01

Childhood cancer is stressful for the entire family. Preoccupation and anxiety surrounding the child's illness may result in parents of children with cancer being overprotective or less emotionally responsive toward their children. Such parenting in response to a negative life event like childhood cancer may cause survivors to be more insecurely attached than healthy peers, which could have downstream effects on survivors' romantic relationships later in life. Therefore, we examined survivors' perspectives on parent behaviors, adult attachment, and marital status among adult survivors of childhood cancer relative to controls. One hundred forty-nine young adult survivors and 149 matched controls (M age  = 28, range 20-40) indicated their relationship status (single vs. partnered) and completed standardized questionnaires assessing memories of upbringing (warmth, overprotection, rejection) and adult attachment (avoidance, anxiety). Adult survivors of childhood cancer remembered mothers and fathers as emotionally warmer (d = 0.53/0.30), and mothers as less rejecting than controls (d = 0.30). Adult attachment was overall similar between survivors and controls, but partnered survivors reported particularly low attachment-related anxiety. Childhood cancer was related to higher mother and father warmth, which were associated with lower attachment-related avoidance and in turn with a greater likelihood of being in a relationship. Adult childhood cancer survivors did not remember their parents as overprotective, but reported more positive parenting relative to controls; and similar adult attachment and relationship status. The results were unexpected, but offer novel insights for future prospective studies, which are necessary to better understand psychosocial late effects of childhood cancer.

Radiation protection procedures and dose to the staff in brachytherapy with permanent implant of the sources

International Nuclear Information System (INIS)

Tosi, G.; Cattani, F.

2002-01-01

The treatment of intra capsular prostate cancers with the permanent implantation of low energy sealed radioactive sources (''103 Pd-''125I) offers the same probability of curing the tumours as surgery and external-beam radiotherapy with a minimum incidence of unwanted side-effects. The first attempts of using sealed sources for treating prostate cancers go back to 1917, when Barringer reported the results obtained with the implant of ''236Ra needles. Beginning from that period the interest for prostate brachytherapy has shown a fluctuating trend, due especially to the technological possibilities and to the status of the alternative treatment modalities (surgery, external radiotherapy). The main reason of the substantial failure of brachytherapy as compared to the two other treatment modalities had two main causes: the energy, too high ( E≅ 840 keV), of γ-radiation emitted by ''226 Ra in equilibrium with its decay products and the lack of imaging techniques able to visualize with sufficient accuracy both the prostate and the arrangement, inside it, of the radioactive sources. The employ of low energy γ-emitting radionuclides began in 1974, when Whitmore et al. working at the Sloan Kettering Memorial Cancer Hospital of New York suggested the use of ''125 I sealed sources for the realisation of interstitial permanent implants. Also this attempt, though reducing the side effects typical of the surgical intervention (incontinence, impotence), did non give the expected results in terms of local control of the disease and, as a consequence, of the survival's length. This partial failure was attributed to the fact that, in most cases the dose distribution inside the target volume was not homogeneous, due to the inadequacy of the available imaging techniques used for checking the real position of the sources, during their manual insertion in the tissues. In the last ten years,however, great progresses have been made in the US i maging techniques, in the manufacture of

Evaluation of an interdisciplinary re-isolation policy for patients with previous Clostridium difficile diarrhea.

Science.gov (United States)

Boone, N; Eagan, J A; Gillern, P; Armstrong, D; Sepkowitz, K A

1998-12-01

Diarrhea caused by Clostridium difficile is increasingly recognized as a nosocomial problem. The effectiveness and cost of a new program to decrease nosocomial spread by identifying patients scheduled for readmission who were previously positive for toxin was evaluated. The Memorial Sloan-Kettering Cancer Center is a 410-bed comprehensive cancer center in New York City. Many patients are readmitted during their course of cancer therapy. In 1995 as a result of concern about the nosocomial spread of C difficile, we implemented a policy that all patients who were positive for C difficile toxin in the previous 6 months with no subsequent toxin-negative stool as an outpatient would be placed into contact isolation on readmission pending evaluation of stool specimens. Patients who were previously positive for C difficile toxin were identified to infection control and admitting office databases via computer. Admitting personnel contacted infection control with all readmissions to determine whether a private room was required. Between July 1, 1995, and June 30, 1996, 47 patients who were previously positive for C difficile toxin were readmitted. Before their first scheduled readmission, the specimens for 15 (32%) of these patients were negative for C difficile toxin. They were subsequently cleared as outpatients and were readmitted without isolation. Workup of the remaining 32 patients revealed that the specimens for 7 patients were positive for C difficile toxin and 86 isolation days were used. An additional 25 patients used 107 isolation days and were either cleared after a negative specimen was obtained in-house or discharged without having an appropriate specimen sent. Four patients (9%) had reoccurring C difficile after having toxin-negative stools. We estimate (because outpatient specimens were not collected) the cost incurred at $48,500 annually, including the incremental cost of hospital isolation and equipment. Our policy to control the spread of nosocomial C

Hospital-Based Cancer Profile at the Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

International Nuclear Information System (INIS)

Badar, F.; Mahmood, S.

2015-01-01

Objective: To determine a frequency distribution of the type and clinical profile of cancer cases registered at the Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH and RC). Study Design: A retrospective, observational study. Place and Duration of Study: The SKMCH and RC, Lahore, from December 1994 to December 2012. Methodology: The time period taken into consideration for the three most common diagnoses was December 1994 - December 2012. Summaries were obtained for gender, age-group, and cancer type on: (i) all age-groups, both genders combined; (ii) adults (> 18 years); (iii) adult males (> 18 years); (iv) adult females (> 18 years); and (v) children (18 years). For a subset of cases registered between January 2004 to December 31, 2012 (9 years), summaries on cancers, age, addiction, family history, disease stage, and grade were obtained for the above groups. Statistical Package for Social Sciences, version 19, was used to analyze the data. Results: The most common malignancies, for the 18-year time period, among adults, were those of breast (11,848/ 49,765, 23.81%), lip and oral cavity (3, 291/49, 765, 6.61%), and liver and intrahepatic bile ducts (2, 836/49, 765, 5.70%). Conclusion: Hospital-based results obtained from various oncology hospital and departments, can be considered as an effective way forward in getting a preview of cancer burden in the region. (author)

The First Data Release of the Sloan Digital Sky Survey

CERN Document Server

Abazajian, Kevork; Agüeros, Marcel A.; Allam, Sahar S.; Anderson, Scott F.; Annis, James; Bahcall, Neta A.; Baldry, Ivan K.; Bastian, Steven; AndreasBerlind; Bernardi, Mariangela; Blanton, Michael R.; Blythe, Norman; Bochanski, John J.; Boroski, William N.; Brewington, Howard; Briggs, John W.; Brinkmann, J.; Brunner, Robert J.; Budavari, Tamas; Carey, Larry N.; Carr, Michael A.; Castander, Francisco J.; Chiu, Kuenley; Collinge, Matthew J.; Connolly, A. J.; Covey, Kevin R.; Csabai, István; J.Dalcanton, Julianne; Dodelson, Scott; Doi, Mamoru; Dong, Feng; Eisenstein, Daniel J.; L.Evans, Michael; Fan, Xiaohui; Feldman, Paul D.; Finkbeiner, Douglas P.; Friedman, Scott D.; Frieman, JoshuaA.; Fukugita, Masataka; Gal, Roy R.; Gillespie, Bruce; Glazebrook, Karl; F.Gonzalez, Carlos; Gray, Jim; Grebel, Eva K.; Grodnicki, Lauren; Gunn, James E.; K.Gurbani, Vijay; Hall, Patrick B.; Hao, Lei; Harbeck, Daniel; Harris, Frederick H.; C.Harris, Hugh; Harvanek, Michael; Hawley, Suzanne L.; Heckman, Timothy M.; Helmboldt, J. F.; Hendry, John S.; Hennessy, Gregory S.; Hindsley, Robert B.; Hogg, David W.; J.Holmgren, Donald; Holtzman, Jon A.; Homer, Lee; Hui, Lam; Ichikawa, Shin-ichi; Ichikawa, Takashi; Inkmann, John P.; ˇ, Zeljko Ivezíc; Jester, Sebastian; Johnston, David E.; Jordan, Beatrice; Jordan, Wendell P.; Jorgensen, Anders M.; Juríc, Mario; Kauffmann, Guinevere; M.Kent, Stephen; Kleinman, S. J.; Knapp, G. R.; Kniazev, Alexei Yu.; Kron, Richard G.; JurekKrzesinski; Kunszt, Peter Z.; Kuropatkin, Nickolai; Lamb, Donald Q.; Lampeitl, Hubert; Laubscher, Bryan E.; Lee, Brian C.; Leger, R. French; Li, Nolan; Lidz, Adam; Lin, Huan; Loh, Yeong-Shang; Long, Daniel C.; Loveday, Jon; Lupton, Robert H.; Malik, Tanu; BruceMargon; McGehee, Peregrine M.; McKay, Timothy A.; Meiksin, Avery; A.Miknaitis, Gajus; Moorthy, Bhasker K.; Munn, Jeffrey A.; Murphy, Tara; Nakajima, Reiko; Narayanan, VijayK.; Nash, Thomas; Neilsen, Eric H. Jr.; Newberg, Heidi Jo; Newman, Peter R.; Nichol, Robert C.; Nicinski, Tom; Nieto-Santisteban, Maria; Nitta, Atsuko; MichaelOdenkirchen; Okamura, Sadanori; Ostriker, Jeremiah P.; Owen, Russell; NikhilPadmanabhan; Peoples, John; Pier, Jeffrey R.; Pindor, Bartosz; Pope, Adrian C.; R.Quinn, Thomas; Rafikov, R. R.; Raymond, Sean N.; Richards, Gordon T.; Richmond, Michael W.; Rix, Hans-Walter; Rockosi, Constance M.; Schaye, Joop; Schlegel, David J.; P.Schneider, Donald; Schroeder, Joshua; Scranton, Ryan; Sekiguchi, Maki; Seljak, Uros; Sergey, Gary; Sesar, Branimir; Sheldon, Erin; Shimasaku, Kazu; Siegmund, Walter A.; Silvestri, Nicole M.; Sinisgalli, Allan J.; Sirko, Edwin; Smith, J. Allyn; Smolčíc, Vernesa; Snedden, Stephanie A.; Stebbins, Albert; Steinhardt, Charles; Stinson, Gregory; Stoughton, Chris; Strateva, Iskra V.; Strauss, Michael A.; SubbaRao, Mark; Szalay, Alexander S.; Szapudi, István; Szkody, Paula; Tasca, Lidia; Tegmark, Max; Thakar, Aniruddha R.; Tremonti, Christy; Tucker, Douglas L.; Uomoto, Alan; Vanden Berk, Daniel E.; Vandenberg, Jan; Vogeley, Michael S.; WolfgangVoges; Vogt, Nicole P.; Walkowicz, Lucianne M.; Weinberg, David H.; West, Andrew A.; White, Simon D.M.; Wilhite, Brian C.; Willman, Beth; Xu, Yongzhong; Yanny, Brian; JeanYarger; Yasuda, Naoki; Yip, Ching-Wa; Yocum, D. R.; York, Donald G.; L.Zakamska, Nadia; Zehavi, Idit; Zheng, Wei; Zibetti, Stefano; Zucker, Daniel B.

2003-01-01

The Sloan Digital Sky Survey has validated and made publicly available its First Data Release. This consists of 2099 square degrees of five-band (u, g, r, i, z) imaging data, 186,240 spectra of galaxies, quasars, stars and calibrating blank sky patches selected over 1360 square degrees of this area, and tables of measured parameters from these data. The imaging data go to a depth of r ~ 22.6 and are photometrically and astrometrically calibrated to 2% rms and 100 milli-arcsec rms per coordinate, respectively. The spectra cover the range 3800--9200 A, with a resolution of 1800--2100. Further characteristics of the data are described, as are the data products themselves.

Distribution Of Maximal Luminosity Of Galaxies In The Sloan Digital Sky Survey

CERN Document Server

Regós, E; Rácz, Z; Taghizadeh, M; Ozogany, K

2010-01-01

Extreme value statistics (EVS) is applied to the pixelized distribution of galaxy luminosities in the Sloan Digital Sky Survey (SDSS). We analyze the DR6 Main Galaxy Sample (MGS), divided into red and blue subsamples, as well as the Luminous Red Galaxy Sample (LRGS). A non-parametric comparison of the EVS of the luminosities with the Fisher-Tippett-Gumbel distribution (limit distribution for independent variables distributed by the Press-Schechter law) indicates a good agreement provided uncertainties arising both from the finite size of the samples and from the sample size distribution are accounted for.

The Role of Tumor Metastases Suppressor Gene, Drg-1, in Breast Cancer

Science.gov (United States)

2008-03-01

evidence to validate 14 our data of breast cancer. However, these prostate cells and reagents were existing materials in our lab or purchased by using...J. Lab . Clin. Med. 133, 265–273. Sloane, B.F., Honn, K.V., 1984. Cysteine proteinases and metastasis. Cancer Metastasis Rev. 3, 249–263. Sridhar, S.C... Beest , P. Moerer, K. van der Horn, R. Goldschmeding, T. Logtenberg and H. Clevers: Synergy between tumor suppressor APC and the beta- catenin-Tcf4

Environmental tobacco smoking, mutagen sensitivity, and head and neck squamous cell carcinoma.

Science.gov (United States)

Zhang, Z F; Morgenstern, H; Spitz, M R; Tashkin, D P; Yu, G P; Hsu, T C; Schantz, S P

2000-10-01

Although active tobacco smoking has been considered a major risk factor for head and neck cancer, few studies have evaluated environmental tobacco smoke (ETS) and its interaction with mutagen sensitivity on the risk of head and neck cancer. We investigated the relationship between ETS and head and neck cancer in a case-control study of 173 previously untreated cases with pathologically confirmed diagnoses of squamous cell carcinoma of the head and neck and 176 cancer-free controls at Memorial Sloan-Kettering Cancer Center between 1992 and 1994. A structured questionnaire was used to collect ETS exposure and other covariates including a history of active tobacco smoking and alcohol use. ETS measures include a history of ETS exposure at home and at workplace. The associations between passive smoking and head and neck cancer were analyzed by Mantel-Haenszel methods and logistic regression models. Additive and multiplicative models were used to evaluate effect modifications between ETS and mutagen sensitivity. The crude odds ratio (OR) for ETS exposure was 2.8 [95% confidence intervals (CI), 1.3-6.0]. Controlling for age, sex, race, education, alcohol consumption, pack-years of cigarette smoking, and marijuana use, the risk of squamous cell carcinoma of the head and neck was increased with ETS (adjusted OR, 2.4; 95% CI, 0.9-6.8). Dose-response relationships were observed for the degree of ETS exposure; the adjusted ORs were 2.1 (95% CI, 0.7-6.1) for those with moderate exposure and 3.6 (95% CI, 1.1-11.5) for individuals with heavy exposure (P for trend = 0.025), in comparison with those who never had ETS exposures. These associations and the dose-response relationships were still present when the analysis was restricted to nonactive smoking cases and controls (crude OR, 2.2; 95% CI, 0.6-8.4). Crude odds ratios were 1.8 for those with moderate ETS exposure and 4.3 for individuals with heavy ETS exposure among nonsmoking cases and controls (P for trend = 0.008). More

Manifesto: towards a clinically-oriented psychometrics.

Science.gov (United States)

Vickers, Andrew J; Chen, Ling Y

2017-04-26

New technologies to collect patient - reported outcomes have substantially solved the challenge of integrating a questionnaire in a busy clinical practice. At Memorial Sloan Kettering, we have been collecting patient reported outcomes electronically for many years. Our experience confirms the predicted benefits of obtaining patient reported outcomes but has also raised serious concerns about whether instruments developed for the research setting are appropriate for routine clinical use. We summarize four principles for a clinically - relevant psychometrics. First, minimize patient burden: the use of a large number of items for a single domain may be of interest for research but additional items have little clinical utility. Secondly, use simplified language: patients who do not have good language skills are typically excluded from research studies but will nonetheless present in clinical practice. Third, avoid dumb questions: many questionnaire items are inappropriate when applied to a more general population. Fourth, what works for the group may not work for the individual: group level statistics used to validate survey instruments can obscure problems when applied to a subgroup of patients. There is a need for a clinically-oriented psychometrics to help design, test, and evaluate questionnaires that would be used in routine practice. Developing statistical methods to optimize questionnaires will be highly challenging but needed to bring the potential of patient reported outcomes into widespread clinical use.

Genus Topology of Structure in the Sloan Digital Sky Survey: Model Testing

Science.gov (United States)

Gott, J. Richard, III; Hambrick, D. Clay; Vogeley, Michael S.; Kim, Juhan; Park, Changbom; Choi, Yun-Young; Cen, Renyue; Ostriker, Jeremiah P.; Nagamine, Kentaro

2008-03-01

We measure the three-dimensional topology of large-scale structure in the Sloan Digital Sky Survey (SDSS). This allows the genus statistic to be measured with unprecedented statistical accuracy. The sample size is now sufficiently large to allow the topology to be an important tool for testing galaxy formation models. For comparison, we make mock SDSS samples using several state-of-the-art N-body simulations: the Millennium run of Springel et al. (10 billion particles), the Kim & Park CDM models (1.1 billion particles), and the Cen & Ostriker hydrodynamic code models (8.6 billion cell hydro mesh). Each of these simulations uses a different method for modeling galaxy formation. The SDSS data show a genus curve that is broadly characteristic of that produced by Gaussian random-phase initial conditions. Thus, the data strongly support the standard model of inflation where Gaussian random-phase initial conditions are produced by random quantum fluctuations in the early universe. But on top of this general shape there are measurable differences produced by nonlinear gravitational effects and biasing connected with galaxy formation. The N-body simulations have been tuned to reproduce the power spectrum and multiplicity function but not topology, so topology is an acid test for these models. The data show a "meatball" shift (only partly due to the Sloan Great Wall of galaxies) that differs at the 2.5 σ level from the results of the Millenium run and the Kim & Park dark halo models, even including the effects of cosmic variance.

THE REDSHIFT DISTRIBUTION OF GIANT ARCS IN THE SLOAN GIANT ARCS SURVEY

International Nuclear Information System (INIS)

Bayliss, Matthew B.; Gladders, Michael D.; Koester, Benjamin P.; Oguri, Masamune; Hennawi, Joseph F.; Sharon, Keren; Dahle, Haakon

2011-01-01

We measure the redshift distribution of a sample of 28 giant arcs discovered as a part of the Sloan Giant Arcs Survey. Gemini/GMOS-North spectroscopy provides precise redshifts for 24 arcs, and 'redshift desert' constrains for the remaining 4 arcs. This is a direct measurement of the redshift distribution of a uniformly selected sample of bright giant arcs, which is an observable that can be used to inform efforts to predict giant arc statistics. Our primary giant arc sample has a median redshift z = 1.821 and nearly two-thirds of the arcs, 64%, are sources at z ∼> 1.4, indicating that the population of background sources that are strongly lensed into bright giant arcs resides primarily at high redshift. We also analyze the distribution of redshifts for 19 secondary strongly lensed background sources that are not visually apparent in Sloan Digital Sky Survey imaging, but were identified in deeper follow-up imaging of the lensing cluster fields. Our redshift sample for the secondary sources is not spectroscopically complete, but combining it with our primary giant arc sample suggests that a large fraction of all background galaxies that are strongly lensed by foreground clusters reside at z ∼> 1.4. Kolmogorov-Smirnov tests indicate that our well-selected, spectroscopically complete primary giant arc redshift sample can be reproduced with a model distribution that is constructed from a combination of results from studies of strong-lensing clusters in numerical simulations and observational constraints on the galaxy luminosity function.

Specifically activated memory T cell subsets from cancer patients recognize and reject xenotransplanted autologous tumors

Science.gov (United States)

Beckhove, Philipp; Feuerer, Markus; Dolenc, Mathias; Schuetz, Florian; Choi, Carmen; Sommerfeldt, Nora; Schwendemann, Jochen; Ehlert, Katrin; Altevogt, Peter; Bastert, Gunther; Schirrmacher, Volker; Umansky, Viktor

2004-01-01

Bone marrow of breast cancer patients was found to contain CD8+ T cells specific for peptides derived from breast cancer–associated proteins MUC1 and Her-2/neu. Most of these cells had a central or effector memory phenotype (CD45RA–CD62L+ or CD45RA–CD62L–, respectively). To test their in vivo function, we separated bone marrow–derived CD45RA+ naive or CD45RA–CD45RO+ memory T cells, stimulated them with autologous dendritic cells pulsed with tumor lysate, and transferred them into NOD/SCID mice bearing autologous breast tumors and normal skin transplants. CD45RA– memory but not CD45RA+ naive T cells infiltrated autologous tumor but not skin tissues after the transfer. These tumor-infiltrating cells had a central or effector memory phenotype and produced perforin. Many of them expressed the P-selectin glycoprotein ligand 1 and were found around P-selectin+ tumor endothelium. Tumor infiltration included cluster formation in tumor tissue by memory T cells with cotransferred dendritic cells. It was associated with the induction of tumor cell apoptosis and significant tumor reduction. We thus demonstrate selective homing of memory T cells to human tumors and suggest that tumor rejection is based on the recognition of tumor-associated antigens on tumor cells and dendritic cells by autologous specifically activated central and effector memory T cells. PMID:15232613

Working memory training in survivors of pediatric cancer: a randomized pilot study.

Science.gov (United States)

Hardy, Kristina K; Willard, Victoria W; Allen, Taryn M; Bonner, Melanie J

2013-08-01

Survivors of pediatric brain tumors and acute lymphoblastic leukemia (ALL) are at increased risk for neurocognitive deficits, but few empirically supported treatment options exist. We examined the feasibility and preliminary efficacy of a home-based, computerized working memory training program, CogmedRM, with survivors of childhood cancer. Survivors of brain tumors or ALL (n = 20) with identified deficits in attention and/or working memory were randomized to either the success-adapted computer intervention or a non-adaptive, active control condition. Specifically, children in the adaptive condition completed exercises that became more challenging with each correct trial, whereas those in the non-adaptive version trained with exercises that never increased in difficulty. All participants were asked to complete 25 training sessions at home, with weekly, phone-based coaching support. Brief assessments were completed pre-intervention and post-intervention; outcome measures included both performance-based and parent-report measures of working memory and attention. Eighty-five percent of survivors were compliant with the intervention, with no adverse events reported. After controlling for baseline intellectual functioning, survivors who completed the intervention program evidenced significant post-training improvements in their visual working memory and in parent-rated learning problems compared with those in the active control group. No differences in verbal working memory functioning were evident between groups, however. Home-based, computerized cognitive training demonstrates good feasibility and acceptability in our sample. Children with higher intellectual functioning at baseline appeared to benefit more from the training, although further study is needed to clarify the strength, scope, and particularly the generalizability of potential treatment effects. Copyright © 2012 John Wiley & Sons, Ltd.

Radiotherapy for esophageal cancer

International Nuclear Information System (INIS)

Rich, T.A.; Ajani, J.A.

1988-01-01

These proceedings contain 33 papers grouped under the headings of: Heath memorial award lecture; Large bowel cancer; Esophageal cancer; Pancreatic, Endocrime, and Hepatobiliary cancer; Gastric cancer; Joanne Vandenberge hill award and William O. Russell lectureship in anatomic pathology; and Jeffrey A. Gottlieb memorial lecture

Anarchic desires : deconstructing sexual and moral representations in Joe Orton's entertaining mr. sloane

OpenAIRE

Werner Almeida Alves

2007-01-01

A presente dissertação tem como objetivo apresentar uma leitura da peça Entertaining Mr. Sloane do dramaturgo inglês Joe Orton, investigando de que formas os artifícios literários são construídos para interromper as representações normativas sobre sexualidade e moralidade. Na obra de Orton, os comportamentos e discursos das personagens ignoram autoridades representativas de instituições que, como a família, trabalham para ratificar a noção de modos sexuais ligados à matrix heterossexual que c...

Multifractionated image-guided and stereotactic intensity-modulated radiotherapy of paraspinal tumors: A preliminary report

International Nuclear Information System (INIS)

Yamada, Yoshiya; Lovelock, D. Michael; Yenice, Kamil M.; Bilsky, Mark H.; Hunt, Margaret A.; Zatcky, Joan; Leibel, Steven A.

2005-01-01

Purpose: The use of image-guided and stereotactic intensity-modulated radiotherapy (IMRT) techniques have made the delivery of high-dose radiation to lesions within close proximity to the spinal cord feasible. This report presents clinical and physical data regarding the use of IMRT coupled with noninvasive body frames (stereotactic and image-guided) for multifractionated radiotherapy. Methods and Materials: The Memorial Sloan-Kettering Cancer Center (Memorial) stereotactic body frame (MSBF) and Memorial body cradle (MBC) have been developed as noninvasive immobilizing devices for paraspinal IMRT using stereotactic (MSBF) and image-guided (MBC) techniques. Patients were either previously irradiated or prescribed doses beyond spinal cord tolerance (54 Gy in standard fractionation) and had unresectable gross disease involving the spinal canal. The planning target volume (PTV) was the gross tumor volume with a 1 cm margin. The PTV was not allowed to include the spinal cord contour. All treatment planning was performed using software developed within the institution. Isocenter verification was performed with an in-room computed tomography scan (MSBF) or electronic portal imaging devices, or both. Patients were followed up with serial magnetic resonance imaging every 3-4 months, and no patients were lost to follow-up. Kaplan-Meier statistics were used for analysis of clinical data. Results: Both the MSBF and MBC were able to provide setup accuracy within 2 mm. With a median follow-up of 11 months, 35 patients (14 primary and 21 secondary malignancies) underwent treatment. The median dose previously received was 3000 cGy in 10 fractions. The median dose prescribed for these patients was 2000 cGy/5 fractions (2000-3000 cGy), which provided a median PTV V100 of 88%. In previously unirradiated patients, the median prescribed dose was 7000 cGy (5940-7000 cGy) with a median PTV V100 of 90%. The median Dmax to the cord was 34% and 68% for previously irradiated and never

The Eighth Data Release of the Sloan Digital Sky Survey: First Data from SDSS-III

Energy Technology Data Exchange (ETDEWEB)

Aihara, Hiroaki; /Tokyo U.; Prieto, Carlos Allende; /Laguna U., Tenerife; An, Deokkeun; /Ewha Women' s U., Seoul; Anderson, Scott F.; /Washington U., Seattle, Astron. Dept.; Aubourg, Eric; /APC, Paris /DAPNIA, Saclay; Balbinot, Eduardo; /Rio Grande do Sul U. /Rio de Janeiro Observ.; Beers, Timothy C.; /Michigan State U.; Berlind, Andreas A.; /Vanderbilt U.; Bickerton, Steven J.; /Princeton U.; Bizyaev, Dmitry; /Apache Point Observ.; Blanton, Michael R.; /New York U., CCPP /Penn State U.

2011-01-01

The Sloan Digital Sky Survey (SDSS) started a new phase in August 2008, with new instrumentation and new surveys focused on Galactic structure and chemical evolution, measurements of the baryon oscillation feature in the clustering of galaxies and the quasar Ly{alpha} forest, and a radial velocity search for planets around {approx}8000 stars. This paper describes the first data release of SDSS-III (and the eighth counting from the beginning of the SDSS). The release includes 5-band imaging of roughly 5200 deg{sup 2} in the Southern Galactic Cap, bringing the total footprint of the SDSS imaging to 14,555 deg{sup 2}, or over a third of the Celestial Sphere. All the imaging data have been reprocessed with an improved sky-subtraction algorithm and a final, self-consistent recalibration and flat-field determination. This release also includes all data from the second phase of the Sloan Extension for Galactic Understanding and Evolution (SEGUE-2), consisting of spectroscopy of approximately 118,000 stars at both high and low Galactic latitudes. All the more than half a million stellar spectra obtained with the SDSS spectrograph have been reprocessed through an improved stellar parameters pipeline, which has better determination of metallicity for high metallicity stars.

The prevention and eradication of smallpox: a commentary on Sloane (1755) ‘An account of inoculation’

Science.gov (United States)

Weiss, Robin A.; Esparza, José

2015-01-01

Sir Hans Sloane's account of inoculation as a means to protect against smallpox followed several earlier articles published in Philosophical Transactions on this procedure. Inoculation (also called ‘variolation’) involved the introduction of small amounts of infectious material from smallpox vesicles into the skin of healthy subjects, with the goal of inducing mild symptoms that would result in protection against the more severe naturally acquired disease. It began to be practised in England in 1721 thanks to the efforts of Lady Mary Wortley Montagu who influenced Sloane to promote its use, including the inoculation of the royal family's children. When Edward Jenner's inoculation with the cow pox (‘vaccination’) followed 75 years later as a safer yet equally effective procedure, the scene was set for the eventual control of smallpox epidemics culminating in the worldwide eradication of smallpox in 1977, officially proclaimed by WHO in 1980. Here, we discuss the significance of variolation and vaccination with respect to scientific, public health and ethical controversies concerning these ‘weapons of mass protection’. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society. PMID:25750241

We’re Working On It: Transferring the Sloan Digital Sky Survey from Laboratory to Library

OpenAIRE

Sands, Ashley E.; Borgman, Christine L.; Traweek, Sharon; Wynholds, Laura A.

2014-01-01

This article reports on the transfer of a massive scientific dataset from a national laboratory to a university library, and from one kind of workforce to another. We use the transfer of the Sloan Digital Sky Survey (SDSS) archive to examine the emergence of a new workforce for scientific research data management. Many individuals with diverse educational backgrounds and domain experience are involved in SDSS data management: domain scientists, computer scientists, software and systems engin...

Wnt signaling inhibits CTL memory programming.

Science.gov (United States)

Xiao, Zhengguo; Sun, Zhifeng; Smyth, Kendra; Li, Lei

2013-12-01

Induction of functional CTLs is one of the major goals for vaccine development and cancer therapy. Inflammatory cytokines are critical for memory CTL generation. Wnt signaling is important for CTL priming and memory formation, but its role in cytokine-driven memory CTL programming is unclear. We found that wnt signaling inhibited IL-12-driven CTL activation and memory programming. This impaired memory CTL programming was attributed to up-regulation of eomes and down-regulation of T-bet. Wnt signaling suppressed the mTOR pathway during CTL activation, which was different to its effects on other cell types. Interestingly, the impaired memory CTL programming by wnt was partially rescued by mTOR inhibitor rapamycin. In conclusion, we found that crosstalk between wnt and the IL-12 signaling inhibits T-bet and mTOR pathways and impairs memory programming which can be recovered in part by rapamycin. In addition, direct inhibition of wnt signaling during CTL activation does not affect CTL memory programming. Therefore, wnt signaling may serve as a new tool for CTL manipulation in autoimmune diseases and immune therapy for certain cancers. Copyright © 2013 Elsevier Ltd. All rights reserved.

RADIO-SELECTED QUASARS IN THE SLOAN DIGITAL SKY SURVEY

International Nuclear Information System (INIS)

McGreer, Ian D.; Helfand, David J.; White, Richard L.

2009-01-01

We have conducted a pilot survey for z > 3.5 quasars by combining the FIRST radio survey with the Sloan Digital Sky Survey (SDSS). While SDSS already targets FIRST sources for spectroscopy as quasar candidates, our survey includes fainter quasars and greatly improves the discovery rate by using strict astrometric criteria for matching the radio and optical positions. Our method allows for selection of high-redshift quasars with less color bias than with optical selection, as using radio selection essentially eliminates stellar contamination. We report the results of spectroscopy for 45 candidates, including 29 quasars in the range 0.37 3.5. We compare quasars selected using radio and optical criteria, and find that radio-selected quasars have a much higher fraction of moderately reddened objects. We derive a radio-loud quasar luminosity function at 3.5 < z < 4.0, and find that it is in good agreement with expectations from prior SDSS results.

Sentinel Node Mapping Using Indocyanine Green and Near-infrared Fluorescence Imaging Technology for Uterine Malignancies: Preliminary Experience With the Da Vinci Xi System.

Science.gov (United States)

Siesto, Gabriele; Romano, Fabrizio; Fiamengo, Barbara; Vitobello, Domenico

2016-01-01

Sentinel lymph node (SLN) mapping has emerged as the new frontier for the surgical staging of apparently early-stage cervical and endometrial cancer. Different colorimetric and radioactive tracers, alone and in combination, have been proposed with encouraging results. Fluorometric mapping using indocyanine green (ICG) appears to be a suitable and attractive alternative to provide reliable staging [1-4]. In this video, we present the technique of SLN mapping in 2 cases (1 endometrial and 1 cervical cancer, respectively) using ICG and the near-infrared technology provided by the newest Da Vinci Xi robotic system (Intuitive Surgical Inc., Sunnyvale, CA). Together we report the results of our preliminary experience on the first 20 cases performed. The new robotic Da Vinci Xi system was available at our institution since May 2015. Upon institutional review board/ethical committee approval, all consecutive patients with early-stage endometrial and cervical cancer who were judged suitable for robotic surgery have been enrolled for SLN mapping with ICG. We adopted the Memorial Sloan Kettering Cancer Center SLN algorithm; the tracer was delivered into the cervix in all cases. Four milliliters (1.25 mg/mL) of ICG was injected divided into the 3- and 9-o'clock positions of the cervix alone, with 1 mL deep into the stroma and 1 mL submucosally at the skin incision. Sentinel lymph nodes were examined with a protocol including both ultrastaging with immunohistochemistry [3] and 1-step nucleic acid amplification assay [5,6] under a parallel protocol of study. During the study period, 20 cases were managed; 14 and 6 patients had endometrial and cervical cancer, respectively. SLN was detected in all cases (20/20, 100%). Bilateral SLNs were detected in 17 of 20 (85.0%) cases. Based on preoperative and intraoperative findings, 13 (65.0%) patients received systematic pelvic lymphadenectomy after SLN mapping. Three (15.0%) patients had microscopic nodal metastases on SLN. No

Systematic in-vitro evaluation of the NCI/NIH Developmental Therapeutics Program Approved Oncology Drug Set for the identification of a candidate drug repertoire for MLL-rearranged leukemia

Directory of Open Access Journals (Sweden)

Hoeksema KA

2011-09-01

Full Text Available Kimberley A Hoeksema1, Aarthi Jayanthan1, Todd Cooper2, Lia Gore3, Tanya Trippett4, Jessica Boklan6, Robert J Arceci5, Aru Narendran11Division of Pediatric Oncology, Alberta Children's Hospital, Calgary, AB, Canada; 2Aflac Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA; 3Center for Cancer and Blood Disorders, Children's Hospital, University of Colorado Denver, Aurora, CO, USA; 4Memorial Sloan-Kettering Cancer Center, New York, NY, USA; 5Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA; 6Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ, USAAbstract: Despite significant progress made in the overall cure rate, the prognosis for relapsed and refractory malignancies in children remains extremely poor. Hence, there is an urgent need for studies that enable the timely selection of appropriate agents for Phase I clinical studies. The Pediatric Oncology Experimental Therapeutics Investigators' Consortium (POETIC is systematically evaluating libraries of known and novel compounds for activity against subsets of high-risk pediatric malignancies with defined molecular aberrations for future clinical development. In this report, we describe the in-vitro activity of a diverse panel of approved oncology drugs against MLL-rearranged pediatric leukemia cell lines. Agents in the Approved Oncology Drug Set II (National Cancer Institute/National Institutes of Health Developmental Therapeutics Program were evaluated by in-vitro cytotoxicity assays in pediatric acute lymphoblastic leukemia and acute myeloid leukemia cell lines with MLL gene rearrangements. Validation studies were carried out with patient leukemia cells in culture. Comparative analysis for toxicity against nonmalignant cells was evaluated in normal bone marrow stromal cells and normal human lymphocytes. Results from this study show that 42 of the 89 agents tested have

Micro-Mini & Nano-Dosimetry & Innovative Technologies in Radiation Therapy (MMND&ITRO2016)

Science.gov (United States)

2017-01-01

The biennial MMND (formerly MMD) - IPCT workshops, founded in collaboration with Memorial Sloan Kettering Cancer Center (MSKCC) in 2001, has become an important international multidisciplinary forum for the discussion of advanced dosimetric technology for radiation therapy quality assurance (QA) and space science, as well as advanced technologies for prostate cancer treatment. In more recent years, the interests of participants and the scope of the workshops have extended far beyond prostate cancer treatment alone to include all aspects of radiation therapy, radiation science and technology. We therefore decided to change the name in 2016 to Innovative Technologies in Radiation Oncology (ITRO). MMND ITRO 2016 was held on 26-31 January, 2016 at the beautiful Wrest Point Hotel in Hobart, Tasmania and attracted an outstanding international faculty and nearly 200 delegates from 18 countries (http://mmnditro2016.com/) The MMND 2016 program continued to cover advanced medical physics aspects of IMRT, IGRT, VMAT, SBRT, MRI LINAC, innovative brachytherapy, and synchrotron MRT. The demand for sophisticated real time and high temporal and spatial resolution (down to the submillimetre scale) dosimetry methods and instrumentation for end-to-end QA for these radiotherapy technologies is increasing. Special attention was paid to the contribution of advanced imaging and the application of nanoscience to the recent improvements in imaging and radiotherapy. The last decade has seen great progress in charged particle therapy technology which has spread throughout the world and attracted strong current interest in Australia. This demands a better understanding of the fundamental aspects of ion interactions with biological tissue and the relative biological effectiveness (RBE) of protons and heavy ions. The further development of computational and experimental micro-and nano-dosimetry for ions has important application in radiobiology based treatment planning and space radiation

Micro-Mini and Nano-Dosimetry and Innovative Technologies in Radiation Therapy (MMND and ITRO2016)

International Nuclear Information System (INIS)

2017-01-01

The biennial MMND (formerly MMD) - IPCT workshops, founded in collaboration with Memorial Sloan Kettering Cancer Center (MSKCC) in 2001, has become an important international multidisciplinary forum for the discussion of advanced dosimetric technology for radiation therapy quality assurance (QA) and space science, as well as advanced technologies for prostate cancer treatment. In more recent years, the interests of participants and the scope of the workshops have extended far beyond prostate cancer treatment alone to include all aspects of radiation therapy, radiation science and technology. We therefore decided to change the name in 2016 to Innovative Technologies in Radiation Oncology (ITRO). MMND ITRO 2016 was held on 26-31 January, 2016 at the beautiful Wrest Point Hotel in Hobart, Tasmania and attracted an outstanding international faculty and nearly 200 delegates from 18 countries (http://mmnditro2016.com/) The MMND 2016 program continued to cover advanced medical physics aspects of IMRT, IGRT, VMAT, SBRT, MRI LINAC, innovative brachytherapy, and synchrotron MRT. The demand for sophisticated real time and high temporal and spatial resolution (down to the submillimetre scale) dosimetry methods and instrumentation for end–to-end QA for these radiotherapy technologies is increasing. Special attention was paid to the contribution of advanced imaging and the application of nanoscience to the recent improvements in imaging and radiotherapy. The last decade has seen great progress in charged particle therapy technology which has spread throughout the world and attracted strong current interest in Australia. This demands a better understanding of the fundamental aspects of ion interactions with biological tissue and the relative biological effectiveness (RBE) of protons and heavy ions. The further development of computational and experimental micro-and nano-dosimetry for ions has important application in radiobiology based treatment planning and space radiation

Cancer 'survivor-care': II. Disruption of prefrontal brain activation top-down control of working memory capacity as possible mechanism for chemo-fog/brain (chemotherapy-associated cognitive impairment).

Science.gov (United States)

Raffa, R B

2013-08-01

Cancer chemotherapy-associated cognitive impairments (termed 'chemo-fog' or 'chemo-brain'), particularly in memory, have been self-reported or identified in cancer survivors previously treated with chemotherapy. Although a variety of deficits have been detected, a consistent theme is a detriment in visuospatial working memory. The parietal cortex, a major site of storage of such memory, is implicated in chemotherapy-induced damage. However, if the findings of two recent publications are combined, the (pre)frontal cortex might be an equally viable target. Two recent studies, one postulating a mechanism for 'top-down control' of working memory capacity and another visualizing chemotherapy-induced alterations in brain activation during working memory processing, are reviewed and integrated. A computational model and the proposal that the prefrontal cortex plays a role in working memory via top-down control of parietal working memory capacity is consistent with a recent demonstration of decreased frontal hyperactivation following chemotherapy. Chemotherapy-associated impairment of visuospatial working memory might include the (pre)frontal cortex in addition to the parietal cortex. This provides new opportunity for basic science and clinical investigation. © 2013 John Wiley & Sons Ltd.

New white dwarf and subdwarf stars in the Sloan Digital Sky Survey Data Release 12

OpenAIRE

Kepler, S. O.; Pelisoli, Ingrid; Koester, Detlev; Ourique, Gustavo; Romero, Alejandra Daniela; Reindl, Nicole; Kleinman, Scot J.; Eisenstein, Daniel J.; Valois, A. Dean M.; Amaral, Larissa A.

2015-01-01

We report the discovery of 6576 new spectroscopically confirmed white dwarf and subdwarf stars in the Sloan Digital Sky Survey Data Release 12. We obtain Teff, log g and mass for hydrogen atmospherewhite dwarf stars (DAs) and helium atmospherewhite dwarf stars (DBs), estimate the calcium/helium abundances for the white dwarf stars with metallic lines (DZs) and carbon/helium for carbon-dominated spectra (DQs). We found one central star of a planetary nebula, one ultracompact helium binary (AM ...

Initial Efficacy Testing of an Autobiographical Memory Intervention on Advance Care Planning for Patients With Terminal Cancer.

Science.gov (United States)

Brohard, Cheryl

2017-11-01

To test the efficacy of a novel intervention to facilitate advance care planning.
. Exploratory, quasiexperimental pilot study with two independent groups.
. A large hospice located in the southwestern United States. 
. A convenience sample of 50 participants with terminal cancer enrolled in hospice.
. An autobiographical memory (ABM) intervention used the participants' experiences with cancer and end of life for the purpose of directing advance care planning.
. Two domains of advance care planning, decision making and communication, were measured in relation to 11 variables. The ABM intervention was nonthreatening, short in duration, and easily completed with participants as they recalled, without hesitation, specific personal memories of family and friends who had died and their advance care plans. The Mann-Whitney nonparametric test revealed that participants in the experimental group had a higher average rank than those in the control group for communicating the decision about antibiotics, as well as exhibited a trend toward significance for five other advance care planning variables.
. Findings showed that directive ABMs may be effective in influencing the decision making and communication of advance care planning for terminally ill patients with cancer.
. The current level of understanding about using the ABM intervention suggests that nurses can initiate an advance care planning conversation using this approach.

Cancer on a mammogram is not memorable: readers remember their recalls and not cancers

International Nuclear Information System (INIS)

Pitman, Alexander G.; Kok, Phebe; Zentner, Lucila

2012-01-01

To determine if presence of cancer on a mammogram makes that mammogram more memorable. A total of 100 mammograms (25 cancers) were grouped into 5 sets of 20 cases. Set pairs were presented in five reads to eight radiologist readers. Readers were asked to 'clear' or 'call back' cases, and at post-baseline reads to indicate whether each case was 'new' or 'old ' (remembered from prior read). Two sets were presented only at baseline, to calculate each reader's false recollection rate. For cases presented more than once ('old' cases, 100 presentations) readers could have 'correct memory' or 'memory loss'. Memory performance was defined as odds ratio of correct memory to memory loss. Multivariate logistic data regression analysis identified predictors of memory performance from: reader, set, time since last read, presence of cancer, and whether the case was called back at the last read. Memory performance differed markedly between readers and reader identity was a highly significant predictor of memory performance. Presence of cancer was not a significant predictor of memory performance (odds ratio 0.77, 95% CI: 0.49–1.21). Whether the case was called back at the last read was a highly significant predictor (odds ratio 4.22, 95% CI: 2.70–6.61) for the model incorporating reader variability, and also the model without reader variability (odds ratio 2.67, 95% CI: 1.74–4.08). The only statistically significant predictor of radiologist memory for a mammogram was whether the radiologist 'called it back' at a prior reading round. Presence of cancer on a mammogram did not make it memorable.

The Sloan Digital Sky Survey COADD: 275 deg2 of deep Sloan Digital Sky Survey imaging on stripe 82

International Nuclear Information System (INIS)

Annis, James; Soares-Santos, Marcelle; Dodelson, Scott; Hao, Jiangang; Jester, Sebastian; Johnston, David E.; Kubo, Jeffrey M.; Lampeitl, Hubert; Lin, Huan; Miknaitis, Gajus; Yanny, Brian; Strauss, Michael A.; Gunn, James E.; Lupton, Robert H.; Becker, Andrew C.; Ivezić, Željko; Fan, Xiaohui; Jiang, Linhua; Seo, Hee-Jong; Simet, Melanie

2014-01-01

We present details of the construction and characterization of the coaddition of the Sloan Digital Sky Survey (SDSS) Stripe 82 ugriz imaging data. This survey consists of 275 deg 2 of repeated scanning by the SDSS camera over –50° ≤ α ≤ 60° and –1.°25 ≤ δ ≤ +1.°25 centered on the Celestial Equator. Each piece of sky has ∼20 runs contributing and thus reaches ∼2 mag fainter than the SDSS single pass data, i.e., to r ∼ 23.5 for galaxies. We discuss the image processing of the coaddition, the modeling of the point-spread function (PSF), the calibration, and the production of standard SDSS catalogs. The data have an r-band median seeing of 1.''1 and are calibrated to ≤1%. Star color-color, number counts, and PSF size versus modeled size plots show that the modeling of the PSF is good enough for precision five-band photometry. Structure in the PSF model versus magnitude plot indicates minor PSF modeling errors, leading to misclassification of stars as galaxies, as verified using VVDS spectroscopy. There are a variety of uses for this wide-angle deep imaging data, including galactic structure, photometric redshift computation, cluster finding and cross wavelength measurements, weak lensing cluster mass calibrations, and cosmic shear measurements.

Sloan Digital Sky Survey IV: Mapping the Milky Way, Nearby Galaxies, and the Distant Universe

Science.gov (United States)

Blanton, Michael R.; Bershady, Matthew A.; Abolfathi, Bela; Albareti, Franco D.; Allende Prieto, Carlos; Almeida, Andres; Alonso-García, Javier; Anders, Friedrich; Anderson, Scott F.; Andrews, Brett; Aquino-Ortíz, Erik; Aragón-Salamanca, Alfonso; Argudo-Fernández, Maria; Armengaud, Eric; Aubourg, Eric; Avila-Reese, Vladimir; Badenes, Carles; Bailey, Stephen; Barger, Kathleen A.; Barrera-Ballesteros, Jorge; Bartosz, Curtis; Bates, Dominic; Baumgarten, Falk; Bautista, Julian; Beaton, Rachael; Beers, Timothy C.; Belfiore, Francesco; Bender, Chad F.; Berlind, Andreas A.; Bernardi, Mariangela; Beutler, Florian; Bird, Jonathan C.; Bizyaev, Dmitry; Blanc, Guillermo A.; Blomqvist, Michael; Bolton, Adam S.; Boquien, Médéric; Borissova, Jura; van den Bosch, Remco; Bovy, Jo; Brandt, William N.; Brinkmann, Jonathan; Brownstein, Joel R.; Bundy, Kevin; Burgasser, Adam J.; Burtin, Etienne; Busca, Nicolás G.; Cappellari, Michele; Delgado Carigi, Maria Leticia; Carlberg, Joleen K.; Carnero Rosell, Aurelio; Carrera, Ricardo; Chanover, Nancy J.; Cherinka, Brian; Cheung, Edmond; Gómez Maqueo Chew, Yilen; Chiappini, Cristina; Doohyun Choi, Peter; Chojnowski, Drew; Chuang, Chia-Hsun; Chung, Haeun; Cirolini, Rafael Fernando; Clerc, Nicolas; Cohen, Roger E.; Comparat, Johan; da Costa, Luiz; Cousinou, Marie-Claude; Covey, Kevin; Crane, Jeffrey D.; Croft, Rupert A. C.; Cruz-Gonzalez, Irene; Garrido Cuadra, Daniel; Cunha, Katia; Damke, Guillermo J.; Darling, Jeremy; Davies, Roger; Dawson, Kyle; de la Macorra, Axel; Dell'Agli, Flavia; De Lee, Nathan; Delubac, Timothée; Di Mille, Francesco; Diamond-Stanic, Aleks; Cano-Díaz, Mariana; Donor, John; Downes, Juan José; Drory, Niv; du Mas des Bourboux, Hélion; Duckworth, Christopher J.; Dwelly, Tom; Dyer, Jamie; Ebelke, Garrett; Eigenbrot, Arthur D.; Eisenstein, Daniel J.; Emsellem, Eric; Eracleous, Mike; Escoffier, Stephanie; Evans, Michael L.; Fan, Xiaohui; Fernández-Alvar, Emma; Fernandez-Trincado, J. G.; Feuillet, Diane K.; Finoguenov, Alexis; Fleming, Scott W.; Font-Ribera, Andreu; Fredrickson, Alexander; Freischlad, Gordon; Frinchaboy, Peter M.; Fuentes, Carla E.; Galbany, Lluís; Garcia-Dias, R.; García-Hernández, D. A.; Gaulme, Patrick; Geisler, Doug; Gelfand, Joseph D.; Gil-Marín, Héctor; Gillespie, Bruce A.; Goddard, Daniel; Gonzalez-Perez, Violeta; Grabowski, Kathleen; Green, Paul J.; Grier, Catherine J.; Gunn, James E.; Guo, Hong; Guy, Julien; Hagen, Alex; Hahn, ChangHoon; Hall, Matthew; Harding, Paul; Hasselquist, Sten; Hawley, Suzanne L.; Hearty, Fred; Gonzalez Hernández, Jonay I.; Ho, Shirley; Hogg, David W.; Holley-Bockelmann, Kelly; Holtzman, Jon A.; Holzer, Parker H.; Huehnerhoff, Joseph; Hutchinson, Timothy A.; Hwang, Ho Seong; Ibarra-Medel, Héctor J.; da Silva Ilha, Gabriele; Ivans, Inese I.; Ivory, KeShawn; Jackson, Kelly; Jensen, Trey W.; Johnson, Jennifer A.; Jones, Amy; Jönsson, Henrik; Jullo, Eric; Kamble, Vikrant; Kinemuchi, Karen; Kirkby, David; Kitaura, Francisco-Shu; Klaene, Mark; Knapp, Gillian R.; Kneib, Jean-Paul; Kollmeier, Juna A.; Lacerna, Ivan; Lane, Richard R.; Lang, Dustin; Law, David R.; Lazarz, Daniel; Lee, Youngbae; Le Goff, Jean-Marc; Liang, Fu-Heng; Li, Cheng; Li, Hongyu; Lian, Jianhui; Lima, Marcos; Lin, Lihwai; Lin, Yen-Ting; Bertran de Lis, Sara; Liu, Chao; de Icaza Lizaola, Miguel Angel C.; Long, Dan; Lucatello, Sara; Lundgren, Britt; MacDonald, Nicholas K.; Deconto Machado, Alice; MacLeod, Chelsea L.; Mahadevan, Suvrath; Geimba Maia, Marcio Antonio; Maiolino, Roberto; Majewski, Steven R.; Malanushenko, Elena; Malanushenko, Viktor; Manchado, Arturo; Mao, Shude; Maraston, Claudia; Marques-Chaves, Rui; Masseron, Thomas; Masters, Karen L.; McBride, Cameron K.; McDermid, Richard M.; McGrath, Brianne; McGreer, Ian D.; Medina Peña, Nicolás; Melendez, Matthew; Merloni, Andrea; Merrifield, Michael R.; Meszaros, Szabolcs; Meza, Andres; Minchev, Ivan; Minniti, Dante; Miyaji, Takamitsu; More, Surhud; Mulchaey, John; Müller-Sánchez, Francisco; Muna, Demitri; Munoz, Ricardo R.; Myers, Adam D.; Nair, Preethi; Nandra, Kirpal; Correa do Nascimento, Janaina; Negrete, Alenka; Ness, Melissa; Newman, Jeffrey A.; Nichol, Robert C.; Nidever, David L.; Nitschelm, Christian; Ntelis, Pierros; O'Connell, Julia E.; Oelkers, Ryan J.; Oravetz, Audrey; Oravetz, Daniel; Pace, Zach; Padilla, Nelson; Palanque-Delabrouille, Nathalie; Alonso Palicio, Pedro; Pan, Kaike; Parejko, John K.; Parikh, Taniya; Pâris, Isabelle; Park, Changbom; Patten, Alim Y.; Peirani, Sebastien; Pellejero-Ibanez, Marcos; Penny, Samantha; Percival, Will J.; Perez-Fournon, Ismael; Petitjean, Patrick; Pieri, Matthew M.; Pinsonneault, Marc; Pisani, Alice; Poleski, Radosław; Prada, Francisco; Prakash, Abhishek; Queiroz, Anna Bárbara de Andrade; Raddick, M. Jordan; Raichoor, Anand; Barboza Rembold, Sandro; Richstein, Hannah; Riffel, Rogemar A.; Riffel, Rogério; Rix, Hans-Walter; Robin, Annie C.; Rockosi, Constance M.; Rodríguez-Torres, Sergio; Roman-Lopes, A.; Román-Zúñiga, Carlos; Rosado, Margarita; Ross, Ashley J.; Rossi, Graziano; Ruan, John; Ruggeri, Rossana; Rykoff, Eli S.; Salazar-Albornoz, Salvador; Salvato, Mara; Sánchez, Ariel G.; Aguado, D. S.; Sánchez-Gallego, José R.; Santana, Felipe A.; Santiago, Basílio Xavier; Sayres, Conor; Schiavon, Ricardo P.; da Silva Schimoia, Jaderson; Schlafly, Edward F.; Schlegel, David J.; Schneider, Donald P.; Schultheis, Mathias; Schuster, William J.; Schwope, Axel; Seo, Hee-Jong; Shao, Zhengyi; Shen, Shiyin; Shetrone, Matthew; Shull, Michael; Simon, Joshua D.; Skinner, Danielle; Skrutskie, M. F.; Slosar, Anže; Smith, Verne V.; Sobeck, Jennifer S.; Sobreira, Flavia; Somers, Garrett; Souto, Diogo; Stark, David V.; Stassun, Keivan; Stauffer, Fritz; Steinmetz, Matthias; Storchi-Bergmann, Thaisa; Streblyanska, Alina; Stringfellow, Guy S.; Suárez, Genaro; Sun, Jing; Suzuki, Nao; Szigeti, Laszlo; Taghizadeh-Popp, Manuchehr; Tang, Baitian; Tao, Charling; Tayar, Jamie; Tembe, Mita; Teske, Johanna; Thakar, Aniruddha R.; Thomas, Daniel; Thompson, Benjamin A.; Tinker, Jeremy L.; Tissera, Patricia; Tojeiro, Rita; Hernandez Toledo, Hector; de la Torre, Sylvain; Tremonti, Christy; Troup, Nicholas W.; Valenzuela, Octavio; Martinez Valpuesta, Inma; Vargas-González, Jaime; Vargas-Magaña, Mariana; Vazquez, Jose Alberto; Villanova, Sandro; Vivek, M.; Vogt, Nicole; Wake, David; Walterbos, Rene; Wang, Yuting; Weaver, Benjamin Alan; Weijmans, Anne-Marie; Weinberg, David H.; Westfall, Kyle B.; Whelan, David G.; Wild, Vivienne; Wilson, John; Wood-Vasey, W. M.; Wylezalek, Dominika; Xiao, Ting; Yan, Renbin; Yang, Meng; Ybarra, Jason E.; Yèche, Christophe; Zakamska, Nadia; Zamora, Olga; Zarrouk, Pauline; Zasowski, Gail; Zhang, Kai; Zhao, Gong-Bo; Zheng, Zheng; Zheng, Zheng; Zhou, Xu; Zhou, Zhi-Min; Zhu, Guangtun B.; Zoccali, Manuela; Zou, Hu

2017-07-01

We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (median z˜ 0.03). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between z˜ 0.6 and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July.

Questions and Answers about School-Age Children in Self-Care: A Sloan Work and Family Research Network Fact Sheet

Science.gov (United States)

Sloan Work and Family Research Network, 2009

2009-01-01

The Sloan Work and Family Research Network has prepared Fact Sheets that provide statistical answers to some important questions about work-family and work-life issues. This Fact Sheet includes statistics about Children in Self-Care, and answers the following questions about school-age children in self-care: (1) How many school-age children are in…

Improvement in erection hardness and intercourse success with first dose of sildenafil citrate 100 mg

Directory of Open Access Journals (Sweden)

Mulhall JP

2013-11-01

Full Text Available John P Mulhall,1 Dana L Creanga,2 Vera J Stecher31Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA; 2Consultant to Pfizer Inc., New York, NY, USA; 3Medical Affairs, Primary Care Business Unit, Pfizer Inc., New York, NY, USAPurpose: To determine, in men with erectile dysfunction (ED, the extent of improvement in erection hardness and in the rate of successful sexual intercourse (SSI during the final intercourse attempt using sildenafil 50 mg compared with the subsequent initial attempt after a dose increase to 100 mg.Patients and methods: This post hoc analysis used data from two randomized, double-blind, placebo-controlled studies of flexible-dose sildenafil for the treatment of men with ED, who were given sildenafil 50 mg or matching placebo, to be taken as needed before sexual intercourse. After 2 weeks, those with no tolerability concerns were titrated up to 100 mg, forming the subgroup of this analysis. The main outcome measures were event log data, including an Erection Hardness Score (EHS and a question on SSI (“Did your erection last long enough for you to have successful sexual intercourse?”, for each attempt at sexual intercourse, analyzed by study and treatment group (sildenafil or placebo. Statistical comparisons were conducted by using the Fisher's exact test.Results: In both studies, the sildenafil group had a larger proportion of EHS4 (completely hard and fully rigid erections (P < 0.001 and SSI (P < 0.005 compared with the placebo group, both before and after the dose increase. Between the final 50 mg sildenafil dose and the initial 100 mg sildenafil dose, the outcomes improved and significantly so in the larger study.Conclusion: The improved efficacy with sildenafil 100 mg versus 50 mg, which occurs rapidly, suggests that patients should be encouraged to use 100 mg if they are unable to achieve completely hard and fully rigid erections or SSI with the 50 mg dose

Medikamentöse Therapie des metastasierten Nierenzellkarzinoms

Directory of Open Access Journals (Sweden)

Schmidinger M

2013-01-01

Full Text Available Einleitung: Zum Zeitpunkt der Diagnose eines Nierenzellkarzinoms befinden sich 60 % der Patienten in einem metastasierten Stadium. Screening-Verfahren zur Früherkennung existieren nicht. In den vergangenen 6 Jahren nach jahrzehntelanger Interferon-alpha-Therapie wurde diese Ära mit der Zulassung von neuen, zielgerichteten Therapien revolutioniert. Damit wurden das Gesamt- und das progressionsfreie Überleben dieser Erkrankung erheblich verbessert. Die palliative Nephrektomie stellt jedoch auch in dieser Ära der neuen Therapien den Goldstandard dar. Ergebnisse: In den ersten Studien wurden Patienten nach Versagen von Interferon-alpha eingeschlossen. In diesem Setting gibt es positive Daten zu Sunitinib, Sorafenib und Pazopanib. Später, nach der Zulassung der ersten Tyrosinkinaseinhibitoren, wurden die Studien als richtige Erstlinienstudien ohne Interferon-alpha-Vorbehandlung konzipiert. Die optimale Therapieabfolge sollte nach dem Risikoprofil stratifiziert werden, nämlich vorrangig nach dem so genannten „Memorial Sloan Kettering Cancer Center“- (MSKCC- Risikoscore. Abhängig davon, welcher der 3 Risikogruppen („good“, „intermediate“ oder „poor“ der Patient angehört, empfehlen die Guidelines unterschiedliche Substanzen. In der Erstlinie für „Good“- oder „Intermediate-risk“-Patienten sind Sunitinib, Bevacizumab + Interferon-alpha und Pazopanib eine Standardoption. Sie unterscheiden sich vor allem in ihrem Nebenwirkungsprofil. Daher sollten bei der Wahl der Erstlinie neben dem Risikoscore immer auch die Begleiterkrankungen mit einbezogen werden. Für so genannte „Poor-risk“-Patienten gibt es Daten zu Temsirolimus und Sunitinib. In der Zweitlinie sind Everolimus und Axitinib zur Behandlung zugelassen. Zusammenfassung: Die Behandlung des metastasierten Nierenzellkarzinoms wurde durch die Zulassung von einigen neuen, zielgerichteten Substanzen in den letzten Jahren bereichert. Die optimale Therapieabfolge zur Verbesserung des

Long-term benefit of sunitinib in patients with metastatic renal cell carcinoma in Latin America: retrospective analysis of patient clinical characteristics

Directory of Open Access Journals (Sweden)

Smaletz O

2016-11-01

Full Text Available Oren Smaletz,1 Matias Chacón,2 Ludmila de Oliveira Koch,1 Daniela R de Carvalho Rocha,1 Fernanda C Cardoso1 1Department of Oncology, Hospital Israelita Albert Einstein, São Paulo, Brazil; 2Medical Oncology Department, Alexander Fleming Institute, Buenos Aires, Argentina Objective: To describe the clinical characteristics of Latin American patients with metastatic renal cell carcinoma (mRCC who experienced a progression-free survival (PFS for at least 15 months following treatment with sunitinib. Patients and methods: In this retrospective analysis, mRCC patients in two institutions in Latin America received sunitinib at a starting dose of either 50 mg/day for 4 weeks followed by 2 weeks off treatment (Schedule 4/2 in repeated 6-week cycles or sunitinib 37.5 mg on a continuous daily dosing schedule. Clinical characteristics, tolerability, and PFS data were collected. Results: Twenty-nine patients with long-term clinical benefit from sunitinib were identified between September 2005 and August 2009. Median PFS was 23 months (range: 15–54 months. Two of the 29 patients with prolonged PFS achieved a complete response and additional eleven had a partial response. Most patients were aged <60 years, had good performance status, favorable or intermediate Memorial Sloan Kettering Cancer Center prognostic risk, and disease limited to one or two sites. Dose reduction was necessary in all patients who started sunitinib at 50 mg/day administered on Schedule 4/2. Adverse events leading to dose reduction included grade 3 hand–foot syndrome, mucositis, fatigue, and hypertension. At the time of data cutoff, four patients were still receiving sunitinib treatment. Conclusion: Extended PFS can be achieved in Latin American patients with mRCC treated with sunitinib. Although the small sample size and retrospective nature of this evaluation preclude the identification of pretreatment predictive factors contributing to this benefit, the current analysis warrants

Pleural Intensity-Modulated Radiotherapy for Malignant Pleural Mesothelioma

International Nuclear Information System (INIS)

Rosenzweig, Kenneth E.; Zauderer, Marjorie G.; Laser, Benjamin; Krug, Lee M.; Yorke, Ellen; Sima, Camelia S.; Rimner, Andreas; Flores, Raja; Rusch, Valerie

2012-01-01

Purpose: In patients with malignant pleural mesothelioma who are unable to undergo pneumonectomy, it is difficult to deliver tumoricidal radiation doses to the pleura without significant toxicity. We have implemented a technique of using intensity-modulated radiotherapy (IMRT) to treat these patients, and we report the feasibility and toxicity of this approach. Methods and Materials: Between 2005 and 2010, 36 patients with malignant pleural mesothelioma and two intact lungs (i.e., no previous pneumonectomy) were treated with pleural IMRT to the hemithorax (median dose, 46.8 Gy; range, 41.4–50.4) at Memorial Sloan-Kettering Cancer Center. Results: Of the 36 patients, 56% had right-sided tumors. The histologic type was epithelial in 78%, sarcomatoid in 6%, and mixed in 17%, and 6% had Stage I, 28% had Stage II, 33% had Stage III, and 33% had Stage IV. Thirty-two patients (89%) received induction chemotherapy (mostly cisplatin and pemetrexed); 56% underwent pleurectomy/decortication before IMRT and 44% did not undergo resection. Of the 36 patients evaluable for acute toxicity, 7 (20%) had Grade 3 or worse pneumonitis (including 1 death) and 2 had Grade 3 fatigue. In 30 patients assessable for late toxicity, 5 had continuing Grade 3 pneumonitis. For patients treated with surgery, the 1- and 2-year survival rate was 75% and 53%, and the median survival was 26 months. For patients who did not undergo surgical resection, the 1- and 2-year survival rate was 69% and 28%, and the median survival was 17 months. Conclusions: Treating the intact lung with pleural IMRT in patients with malignant pleural mesothelioma is a safe and feasible treatment option with an acceptable rate of pneumonitis. Additionally, the survival rates were encouraging in our retrospective series, particularly for the patients who underwent pleurectomy/decortication. We have initiated a Phase II trial of induction chemotherapy with pemetrexed and cisplatin with or without pleurectomy

Pleural Intensity-Modulated Radiotherapy for Malignant Pleural Mesothelioma

Energy Technology Data Exchange (ETDEWEB)

Rosenzweig, Kenneth E., E-mail: ken.rosenzweig@mountsinai.org [Department of Radiation Oncology, Mount Sinai Medical Center, New York, NY (United States); Zauderer, Marjorie G. [Department of Medicine, Thoracic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Laser, Benjamin [Department of Radiation Oncology, Henry Ford Hospital, Detroit, MI (United States); Krug, Lee M. [Department of Medicine, Thoracic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Yorke, Ellen [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Sima, Camelia S. [Department of Epidemiology/Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Rimner, Andreas [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Flores, Raja [Department of Surgery, Mount Sinai Medical Center, New York, NY (United States); Rusch, Valerie [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)

2012-07-15

Purpose: In patients with malignant pleural mesothelioma who are unable to undergo pneumonectomy, it is difficult to deliver tumoricidal radiation doses to the pleura without significant toxicity. We have implemented a technique of using intensity-modulated radiotherapy (IMRT) to treat these patients, and we report the feasibility and toxicity of this approach. Methods and Materials: Between 2005 and 2010, 36 patients with malignant pleural mesothelioma and two intact lungs (i.e., no previous pneumonectomy) were treated with pleural IMRT to the hemithorax (median dose, 46.8 Gy; range, 41.4-50.4) at Memorial Sloan-Kettering Cancer Center. Results: Of the 36 patients, 56% had right-sided tumors. The histologic type was epithelial in 78%, sarcomatoid in 6%, and mixed in 17%, and 6% had Stage I, 28% had Stage II, 33% had Stage III, and 33% had Stage IV. Thirty-two patients (89%) received induction chemotherapy (mostly cisplatin and pemetrexed); 56% underwent pleurectomy/decortication before IMRT and 44% did not undergo resection. Of the 36 patients evaluable for acute toxicity, 7 (20%) had Grade 3 or worse pneumonitis (including 1 death) and 2 had Grade 3 fatigue. In 30 patients assessable for late toxicity, 5 had continuing Grade 3 pneumonitis. For patients treated with surgery, the 1- and 2-year survival rate was 75% and 53%, and the median survival was 26 months. For patients who did not undergo surgical resection, the 1- and 2-year survival rate was 69% and 28%, and the median survival was 17 months. Conclusions: Treating the intact lung with pleural IMRT in patients with malignant pleural mesothelioma is a safe and feasible treatment option with an acceptable rate of pneumonitis. Additionally, the survival rates were encouraging in our retrospective series, particularly for the patients who underwent pleurectomy/decortication. We have initiated a Phase II trial of induction chemotherapy with pemetrexed and cisplatin with or without pleurectomy

A list of personal perspectives with selected quotations, along with lists of tributes, historical notes, Nobel and Kettering awards related to photosynthesis.

Science.gov (United States)

Krogmann, David W

2002-01-01

The history of photosynthesis research can be found in original papers and books. However, a special history is available from the prefatory chapters and the personal perspectives of various researchers who published them in several journals over the last 40 years. We have compiled a list of such perspectives published since 1964. Selection is not easy, especially of authors who were not directly engaged in photosynthesis research; some are included for their special insights related to central issues in the study of photosynthesis. Our journal, Photosynthesis Research, contains other valuable historic data in the occasional tributes, obituaries and historical notes, that have been published. Lists of these items are included. This article ends by listing the Nobel prizes related to photosynthesis and the Kettering Awards for Excellence in Photosynthesis Research. Wherever possible, a web page address is provided. The web page addresses have been taken from the article 'Photosynthesis and the Web: 2001' by Larry Orr and Govindjee, available at http://www.life.uiuc.edu/govindjee/photoweb and at http://photoscience.la.asu.edu/photosyn/ photoweb/default.html.When I find a bit of leisureI trifle with my papers.This is one of the lesserfrailities.'- Horace, Satires I, IV.

Differentiated thyroid cancer: reclassification of the risk of recurrence based on the response to initial treatment; Carcinoma diferenciado de tiroides: reclasificación del riesgo de recurrencia según la respuesta al tratamiento inicial

Energy Technology Data Exchange (ETDEWEB)

Martínez, M. P.; Lozano Bullrich, M. P.; Rey, M.; Ridruejo, M. C.; Bomarito, M. J.; Claus Hermberg, H.; Pozzo, M.J., E-mail: mpazmartinez@yahoo.com [Hospital Alemán, Servicio de Endocrinología, Buenos Aires (Argentina)

2014-07-01

Introduction: differentiated thyroid cancer (DTC) is the most frequent endocrine tumor generally showing a favourable outcome. The American Thyroid Association (ATA) classification system is not only useful to assess the risk of recurrence but also guides tumor follow-up. However, this system shows a static image of the patient at the beginning of treatment based on clinical and pathological features, and it has not been designed to be modified along the clinical course of disease. Therefore, the Memorial Sloan-Kettering Cancer Center (MS-KCC) has designed a reclassification system after 2 years of the initial treatment (IT) thus providing a dynamic perspective of each patient. Objective: to report our experience with the MS-KCC risk of recurrence reclassification system on DTC patients. Materials and methods: retrospective observational descriptive study of the results of the reclassification system of the DCT patients after two years of IT with surgery and radioiodine ablation, between October 2004 and April 2011. Data was obtained by reviewing the charts of patients. All surgeries, laboratory determinations and nuclear medicine procedures took place at our Hospital. Patients were classified according to initial risk of recurrence based on the ATA system and they were reclassified following the system proposed by the MS-KCC 2 years after IT. Patients with antithyroglobulin antibodies > 12 IU/ml were excluded due to interference with thyroglobulin determination. Results: we reviewed data of 31 patients diagnosed with DTC. They were classified according to the ATA system as: low risk 17 (54.8 %), intermediate risk 13 (42 %) and high risk 1 (3.2 %) and they were reclassified following the MS-KCC system as having: excellent response 25 (80.6 %), acceptable response 6 (19.4 %) and incomplete response 0 (0 %). An excellent response was observed in 14 (82.4 %) and an acceptable response was observed in 3 (17.6 %) of the low-risk classified patients; an excellent

An Improved Photometric Calibration of the Sloan Digital SkySurvey Imaging Data

Energy Technology Data Exchange (ETDEWEB)

Padmanabhan, Nikhil; Schlegel, David J.; Finkbeiner, Douglas P.; Barentine, J.C.; Blanton, Michael R.; Brewington, Howard J.; Gunn, JamesE.; Harvanek, Michael; Hogg, David W.; Ivezic, Zeljko; Johnston, David; Kent, Stephen M.; Kleinman, S.J.; Knapp, Gillian R.; Krzesinski, Jurek; Long, Dan; Neilsen Jr., Eric H.; Nitta, Atsuko; Loomis, Craig; Lupton,Robert H.; Roweis, Sam; Snedden, Stephanie A.; Strauss, Michael A.; Tucker, Douglas L.

2007-09-30

We present an algorithm to photometrically calibrate widefield optical imaging surveys, that simultaneously solves for thecalibration parameters and relative stellar fluxes using overlappingobservations. The algorithm decouples the problem of "relative"calibrations from that of "absolute" calibrations; the absolutecalibration is reduced to determining a few numbers for the entiresurvey. We pay special attention to the spatial structure of thecalibration errors, allowing one to isolate particular error modes indownstream analyses. Applying this to the SloanDigital Sky Survey imagingdata, we achieve ~;1 percent relative calibration errors across 8500sq.deg/ in griz; the errors are ~;2 percent for the u band. These errorsare dominated by unmodelled atmospheric variations at Apache PointObservatory. These calibrations, dubbed ubercalibration, are now publicwith SDSS Data Release 6, and will be a part of subsequent SDSS datareleases.

The Second Data Release of the Sloan Digital Sky Survey

CERN Document Server

Abazajian, Kevork; ̈ueros, Marcel A. Ag; Allam, Sahar S.; Anderson, KurtS. J.; Anderson, Scott F.; Annis, James; Bahcall, Neta A.; Baldry, Ivan K.; StevenBastian; Berlind, Andreas; Bernardi, Mariangela; Blanton, Michael R.; BochanskiJr., John J.; Boroski, William N.; Briggs, John W.; Brinkmann, J.; Brunner, Robert J.; ́ari, Tam ́asBudav; Carey, Larry N.; Carliles, Samuel; Castander, Francisco J.; Connolly, A. J.; Csabai, Istvan; Doi, Mamoru; Dong, Feng; Eisenstein, Daniel J.; Evans, Michael L.; Fan, Xiaohui; Finkbeiner, Douglas P.; Friedman, Scott D.; Frieman, Joshua A.; Fukugita, Masataka; Gal, RoyR.; Gillespie, Bruce; Glazebrook, Karl; Gray, Jim; Grebel, Eva K.; Gunn, James E.; Gurbani, Vijay K.; Hall, Patrick B.; Hamabe, Masaru; Harris, Frederick H.; C.Harris, Hugh; Harvanek, Michael; Heckman, Timothy M.; Hendry, John S.; Hennessy, Gregory S.; Hindsley, Robert B.; Hogan, Craig J.; Hogg, David W.; Holmgren, Donald J.; Ichikawa, Shin-ichi; Ichikawa, Takashi; Ivezic, Zeljko; Jester, Sebastian; Johnston, David E.; Jorgensen, AndersM.; Kent, Stephen M.; Kleinman, S. J.; Knapp, G. R.; Kniazev, Alexei Yu.; Kron, Richard G.; Krzesinski, Jurek; Kunszt, Peter Z.; Kuropatkin, Nickolai; Q.Lamb, Donald; Lampeitl, Hubert; Lee, Brian C.; Leger, R. French; Li, Nolan; Lin, Huan; Loh, Yeong-Shang; Long, Daniel C.; Loveday, Jon; Lupton, Robert H.; Malik, Tanu; BruceMargon; Matsubara, Takahiko; McGehee, Peregrine M.; McKay, Timothy A.; AveryMeiksin; Munn, Jeffrey A.; Nakajima, Reiko; Nash, Thomas; Neilsen, Eric H. Jr.; JoNewberg, Heidi; Newman, Peter R.; Nichol, Robert C.; Nicinski, Tom; Nieto-Santisteban, Maria; Nitta, Atsuko; Okamura, Sadanori; O'Mullane, William; Ostriker, Jeremiah P.; Owen, Russell; Padmanabhan, Nikhil; Peoples, John; Pier, Jeffrey R.; Pope, Adrian C.; Quinn, Thomas R.; Richards, Gordon T.; Richmond, Michael W.; Rix, Hans-Walter; Rockosi, Constance M.; Schlegel, David J.; Schneider, Donald P.; Scranton, Ryan; Sekiguchi, Maki; Seljak, Uros; Sergey, Gary; Sesar, Branimir; Sheldon, Erin; Shimasaku, Kazu; Siegmund, Walter A.; Silvestri, Nicole M.; Smith, J. Allyn; ́c, Vernesa Smolči; Snedden, Stephanie A.; AlbertStebbins; Stoughton, Chris; Strauss, Michael A.; SubbaRao, Mark; Szalay, Alexander S.; Szapudi, Istv ́an; Szkody, Paula; Szokoly, Gyula P.; Tegmark, Max; Teodoro, Luis; Thakar, AniruddhaR.; Tremonti, Christy; Tucker, Douglas L.; Uomoto, Alan; Vanden Berk, Daniel E.; Vandenberg, Jan; Vogeley, Michael S.; Voges, Wolfgang; Vogt, Nicole P.; M.Walkowicz, Lucianne; Wang, Shu-i; Weinberg, David H.; West, Andrew A.; White, Simon D.M.; Wilhite, BrianC.; Xu, Yongzhong; Yanny, Brian; Yasuda, Naoki; Yip, Ching-Wa; Yocum, D. R.; York, Donald G.; Zehavi, Idit; Zibetti, Stefano; Zucker, Daniel B.

2004-01-01

The Sloan Digital Sky Survey has validated and made publicly available its Second Data Release. This data release consists of 3324 square degrees of five-band (u g r i z) imaging data with photometry for over 88 million unique objects, 367,360 spectra of galaxies, quasars, stars and calibrating blank sky patches selected over 2627 degrees of this area, and tables of measured parameters from these data. The imaging data reach a depth of r ~ 22.2 (95% completeness limit for point sources) and are photometrically and astrometrically calibrated to 2% rms and 100 milli-arcsec rms per coordinate, respectively. The imaging data have all been processed through a new version of the SDSS imaging pipeline, in which the most important improvement since the last data release is fixing an error in the model fits to each object. The result is that model magnitudes are now a good proxy for point spread function (PSF) magnitudes for point sources, and Petrosian magnitudes for extended sources. The spectroscopy extends from 38...

Ensemble Properties of Comets in the Sloan Digital Sky Survey

Energy Technology Data Exchange (ETDEWEB)

Solontoi, Michael; /Adler Planetarium, Chicago; Ivezic, Zeljko; /Washington U., Seattle, Astron. Dept.; Juric, Mario; /Harvard Coll. Observ.; Becker, Andrew C.; /Washington U., Seattle, Astron. Dept.; Jones, Lynne; /Washington U., Seattle, Astron. Dept.; West, Andrew A.; /Boston U.; Kent, Steve; /Fermilab; Lupton, Robert H.; /Princeton U. Observ.; Claire, Mark; /Washington U., Seattle, Astron. Dept.; Knapp, Gillian R.; /Princeton U. Observ.; Quinn, Tom; /Washington U., Seattle, Astron. Dept. /Princeton U. Observ.

2012-02-01

We present the ensemble properties of 31 comets (27 resolved and 4 unresolved) observed by the Sloan Digital Sky Survey (SDSS). This sample of comets represents about 1 comet per 10 million SDSS photometric objects. Five-band (u, g, r, i, z) photometry is used to determine the comets colors, sizes, surface brightness profiles, and rates of dust production in terms of the Afp formalism. We find that the cumulative luminosity function for the Jupiter Family Comets in our sample is well fit by a power law of the form N(

IMPROVED BACKGROUND SUBTRACTION FOR THE SLOAN DIGITAL SKY SURVEY IMAGES

International Nuclear Information System (INIS)

Blanton, Michael R.; Kazin, Eyal; Muna, Demitri; Weaver, Benjamin A.; Price-Whelan, Adrian

2011-01-01

We describe a procedure for background subtracting Sloan Digital Sky Survey (SDSS) imaging that improves the resulting detection and photometry of large galaxies on the sky. Within each SDSS drift scan run, we mask out detected sources and then fit a smooth function to the variation of the sky background. This procedure has been applied to all SDSS-III Data Release 8 images, and the results are available as part of that data set. We have tested the effect of our background subtraction on the photometry of large galaxies by inserting fake galaxies into the raw pixels, reanalyzing the data, and measuring them after background subtraction. Our technique results in no size-dependent bias in galaxy fluxes up to half-light radii r 50 ∼ 100 arcsec; in contrast, for galaxies of that size the standard SDSS photometric catalog underestimates fluxes by about 1.5 mag. Our results represent a substantial improvement over the standard SDSS catalog results and should form the basis of any analysis of nearby galaxies using the SDSS imaging data.

APASS Landolt-Sloan BVgri photometry of Rave stars. I. Data, effective temperatures, and reddenings

Energy Technology Data Exchange (ETDEWEB)

Munari, U.; Siviero, A. [INAF Osservatorio Astronomico di Padova, I-36012 Asiago (VI) (Italy); Henden, A. [AAVSO, Cambridge, MA (United States); Frigo, A. [ANS Collaboration, c/o Astronomical Observatory, Padova (Italy); Zwitter, T. [Faculty of Mathematics and Physics, University of Ljubljana, 1000 Ljubljana (Slovenia); Bienaymé, O.; Siebert, A. [Observatoire Astronomique, Université de Strasbourg, CNRS, 11 rue de l' université F-67000 Strasbourg (France); Bland-Hawthorn, J. [Sydney Institute for Astronomy, University of Sydney, NSW 2006 (Australia); Boeche, C.; Grebel, E. K. [Astronomisches Rechen-Institut, Zentrum für Astronomie der Universität Heidelberg, Mönchhofstr. 12-14, D-69120 Heidelberg (Germany); Freeman, K. C. [Mount Stromlo Observatory, RSAA, Australian National University, Weston Creek, Canberra, ACT 2611 (Australia); Gibson, B. K. [Jeremiah Horrocks Institute, University of Central Lancashire, Preston, PR1 2HE (United Kingdom); Gilmore, G.; Kordopatis, G. [Institute of Astronomy, Cambridge University, Madingley Road, Cambridge CB3 0HA (United Kingdom); Helmi, A. [Kapteyn Astronomical Institute, University of Groningen, PO Box 800, 9700 AV Groningen (Netherlands); Levine, S. E. [Lowell Observatory, Flagstaff, AZ (United States); Navarro, J. F. [Department of Physics and Astronomy, University of Victoria, Victoria, BC V8P 5C2 (Canada); Parker, Q. A.; Reid, W. [Department of Physics and Astronomy, Macquarie University, NSW 2109 (Australia); Seabroke, G. M. [Mullard Space Science Laboratory, University College London, Holmbury St. Mary, Dorking, RH5 6NT (United Kingdom); and others

2014-11-01

We provide AAVSO Photometric All-Sky Survey (APASS) photometry in the Landolt BV and Sloan g'r'i' bands for all 425,743 stars included in the fourth RAVE Data Release. The internal accuracy of the APASS photometry of RAVE stars, expressed as the error of the mean of data obtained and separately calibrated over a median of four distinct observing epochs and distributed between 2009 and 2013, is 0.013, 0.012, 0.012, 0.014, and 0.021 mag for the B, V, g', r', and i' bands, respectively. The equally high external accuracy of APASS photometry has been verified on secondary Landolt and Sloan photometric standard stars not involved in the APASS calibration process and on a large body of literature data on field and cluster stars, confirming the absence of offsets and trends. Compared with the Carlsberg Meridian Catalog (CMC-15), APASS astrometry of RAVE stars is accurate to a median value of 0.098 arcsec. Brightness distribution functions for the RAVE stars have been derived in all bands. APASS photometry of RAVE stars, augmented by 2MASS JHK infrared data, has been χ{sup 2} fitted to a densely populated synthetic photometric library designed to widely explore temperature, surface gravity, metallicity, and reddening. Resulting T {sub eff} and E {sub B–V}, computed over a range of options, are provided and discussed, and will be kept updated in response to future APASS and RAVE data releases. In the process, we find that the reddening caused by a homogeneous slab of dust, extending for 140 pc on either side of the Galactic plane and responsible for E{sub B−V}{sup poles} = 0.036 ± 0.002 at the Galactic poles, is a suitable approximation of the actual reddening encountered at Galactic latitudes |b| ≥ 25°.

APASS Landolt-Sloan BVgri Photometry of RAVE Stars. I. Data, Effective Temperatures, and Reddenings

Science.gov (United States)

Munari, U.; Henden, A.; Frigo, A.; Zwitter, T.; Bienaymé, O.; Bland-Hawthorn, J.; Boeche, C.; Freeman, K. C.; Gibson, B. K.; Gilmore, G.; Grebel, E. K.; Helmi, A.; Kordopatis, G.; Levine, S. E.; Navarro, J. F.; Parker, Q. A.; Reid, W.; Seabroke, G. M.; Siebert, A.; Siviero, A.; Smith, T. C.; Steinmetz, M.; Templeton, M.; Terrell, D.; Welch, D. L.; Williams, M.; Wyse, R. F. G.

2014-11-01

We provide AAVSO Photometric All-Sky Survey (APASS) photometry in the Landolt BV and Sloan g'r'i' bands for all 425,743 stars included in the fourth RAVE Data Release. The internal accuracy of the APASS photometry of RAVE stars, expressed as the error of the mean of data obtained and separately calibrated over a median of four distinct observing epochs and distributed between 2009 and 2013, is 0.013, 0.012, 0.012, 0.014, and 0.021 mag for the B, V, g', r', and i' bands, respectively. The equally high external accuracy of APASS photometry has been verified on secondary Landolt and Sloan photometric standard stars not involved in the APASS calibration process and on a large body of literature data on field and cluster stars, confirming the absence of offsets and trends. Compared with the Carlsberg Meridian Catalog (CMC-15), APASS astrometry of RAVE stars is accurate to a median value of 0.098 arcsec. Brightness distribution functions for the RAVE stars have been derived in all bands. APASS photometry of RAVE stars, augmented by 2MASS JHK infrared data, has been χ2 fitted to a densely populated synthetic photometric library designed to widely explore temperature, surface gravity, metallicity, and reddening. Resulting T eff and E B - V , computed over a range of options, are provided and discussed, and will be kept updated in response to future APASS and RAVE data releases. In the process, we find that the reddening caused by a homogeneous slab of dust, extending for 140 pc on either side of the Galactic plane and responsible for EpolesB-V = 0.036 ± 0.002 at the Galactic poles, is a suitable approximation of the actual reddening encountered at Galactic latitudes |b| >= 25°.

Assessing cancer-specific anxiety in Chinese men with prostate cancer: psychometric evaluation of the Chinese version of the Memorial Anxiety Scale for Prostate Cancer (MAX-PC).

Science.gov (United States)

Huang, Qingmei; Jiang, Ping; Zhang, Zijun; Luo, Jie; Dai, Yun; Zheng, Li; Wang, Wei

2017-12-01

The Memorial Anxiety Scale for Prostate Cancer (MAX-PC) was developed to identify and assess cancer-specific anxiety among men with prostate cancer (PCa); however, there is no Chinese version. The aim of our study was to translate the English version of MAX-PC into Chinese and evaluate the psychometric properties of it. The study cohort comprised 254 participants. Internal consistency including the Cronbach's alpha coefficient and item-total correlations were used to measure the reliability of the scale. Factor structure was analyzed by exploratory factor analysis and concurrent validity by comparing MAX-PC scores with anxiety subscale scores of the Hospital Anxiety and Depression Scale (HADS). Divergent validity was assessed by correlating MAX-PC with HADS depression subscale, while discriminant ability by comparing differences in MAX-PC scores between different patient groups. The Chinese version of MAX-PC demonstrated good reliability; the Cronbach's alpha coefficient for the total and three subscales (prostate cancer anxiety, PSA anxiety, and fear of recurrence) being 0.94, 0.93, 0.82, and 0.85, respectively. Exploratory factor analysis supported the three-factor structure of the scale established in the original version. Despite the somewhat underperformed divergent validity, the scale demonstrated good concurrent validity with a strong correlation with the HADS anxiety subscale (r = 0.71, p anxiety in Chinese PCa patients.

Acute memory deficits in chemotherapy-treated adults.

Science.gov (United States)

Lindner, Oana C; Mayes, Andrew; McCabe, Martin G; Talmi, Deborah

2017-11-01

Data from research on amnesia and epilepsy are equivocal with regards to the dissociation, shown in animal models, between rapid and slow long-term memory consolidation. Cancer treatments have lasting disruptive effects on memory and on brain structures associated with memory, but their acute effects on synaptic consolidation are unknown. We investigated the hypothesis that cancer treatment selectively impairs slow synaptic consolidation. Cancer patients and their matched controls were administered a novel list-learning task modelled on the Rey Auditory Verbal Learning Test. Learning, forgetting, and retrieval were tested before, and one day after patients' first chemotherapy treatment. Due to difficulties recruiting cancer patients at that sensitive time, we were only able to study 10 patients and their matched controls. Patients exhibited treatment-dependent accelerated forgetting over 24 hours compared to their own pre-treatment performance and to the performance of control participants, in agreement with our hypothesis. The number of intrusions increased after treatment, suggesting retrieval deficits. Future research with larger samples should adapt our methods to distinguish between consolidation and retrieval causes for treatment-dependent accelerated forgetting. The presence of significant accelerated forgetting in our small sample is indicative of a potentially large acute effect of chemotherapy treatment on forgetting, with potentially clinically relevant implications.

Preserved learning and memory following 5-fluorouracil and cyclophosphamide treatment in rats

OpenAIRE

Long, Jeffrey M.; Lee, Garrick D.; Kelley-Bell, Bennett; Spangler, Edward L.; Perez, Evelyn J.; Longo, Dan L.; de Cabo, Rafael; Zou, Sige; Rapp, Peter R.

2011-01-01

Some patients experience enduring cognitive impairment after cancer treatment, a condition termed “chemofog”. Animal models allow assessment of chemotherapy effects on learning and memory per se, independent of changes due to cancer itself or associated health consequences such as depression. The present study examined the long-term learning and memory effects of a chemotherapy cocktail used widely in the treatment of breast cancer, consisting of 5-fluorouracil (5FU) and cyclophosphamide (CYP...

Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance.

Science.gov (United States)

Gebhardt, Thomas; Palendira, Umaimainthan; Tscharke, David C; Bedoui, Sammy

2018-05-01

A large proportion of memory T cells disseminated throughout the body are non-recirculating cells whose maintenance and function is regulated by tissue-specific environmental cues. These sessile cells are referred to as tissue-resident memory T (T RM ) cells and similar populations of non-recirculating cells also exist among unconventional T cells and innate lymphocyte cells. The pool of T RM cells is highly diverse with respect to anatomical positioning, phenotype, molecular regulation and effector function. Nevertheless, certain transcriptional programs are shared and appear as important unifying features for the overall population of T RM cells and tissue-resident lymphocytes. It is now widely appreciated that T RM cells are a critical component of our immune defense by acting as peripheral sentinels capable of rapidly mobilizing protective tissue immunity upon pathogen recognition. This function is of particular importance in anatomical sites that are not effectively surveilled by blood-borne memory T cells in absence of inflammation, such as neuronal tissues or epithelial compartments in skin and mucosae. Focusing on the well-characterized subtype of CD8 +  CD69 +  CD103 + T RM cells, we will review current concepts on the generation, persistence and function of T RM cells and will summarize commonly used tools to study these cells. Furthermore, we will discuss accumulating data that emphasize localized T RM responses as an important determinant of tissue homeostasis and immune defense in the context of microbiota-immune interactions, persistent infections and cancer surveillance. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Narrow absorption lines with two observations from the Sloan Digital Sky Survey

Science.gov (United States)

Chen, Zhi-Fu; Gu, Qiu-Sheng; Chen, Yan-Mei; Cao, Yue

2015-07-01

We assemble 3524 quasars from the Sloan Digital Sky Survey (SDSS) with repeated observations to search for variations of the narrow C IV λ λ 1548,1551 and Mg II λ λ 2796,2803 absorption doublets in spectral regions shortward of 7000 Å in the observed frame, which corresponds to time-scales of about 150-2643 d in the quasar rest frame. In these quasar spectra, we detect 3580 C IV absorption systems with zabs = 1.5188-3.5212 and 1809 Mg II absorption systems with zabs = 0.3948-1.7167. In term of the absorber velocity (β) distribution in the quasar rest frame, we find a substantial number of C IV absorbers with β Hacker et al. However, in our Mg II absorption sample, we find that neither shows variable absorption with confident levels of >4σ for λ2796 lines and >3σ for λ2803 lines.

Examining the Extent and Nature of Online Learning in American K-12 Education: The Research Initiatives of the Alfred P. Sloan Foundation

Science.gov (United States)

Picciano, Anthony G.; Seaman, Jeff; Shea, Peter; Swan, Karen

2012-01-01

In 1992, the Alfred P. Sloan Foundation began its "Anytime, Anyplace Learning Program", the purpose of which was to explore educational alternatives for people who wanted to pursue an education via Internet technology. Part of this grant activity was a research award to the Babson College Survey Research Group to examine online learning in…

Local Control With 21-Gy Radiation Therapy for High-Risk Neuroblastoma

International Nuclear Information System (INIS)

Casey, Dana L.; Kushner, Brian H.; Cheung, Nai-Kong V.; Modak, Shakeel; LaQuaglia, Michael P.; Wolden, Suzanne L.

2016-01-01

Purpose: To evaluate local control after 21-Gy radiation therapy (RT) to the primary site in patients with high-risk neuroblastoma. Methods and Materials: After receiving dose-intensive chemotherapy and gross total resection (GTR), 246 patients (aged 1.2-17.9 years, median 4.0 years) with high-risk neuroblastoma underwent RT to the primary site at Memorial Sloan Kettering from 2000 to 2014. Radiation therapy consisted of 21 Gy in twice-daily fractions of 1.5 Gy each. Local failure (LF) was correlated with biologic prognostic factors and clinical findings at the time of diagnosis and start of RT. Results: Median follow-up of surviving patients was 6.4 years. Cumulative incidence of LF was 7.1% at 2 years after RT and 9.8% at 5 years after RT. The isolated LF rate was 3.0%. Eighty-six percent of all local failures were within the RT field. Local control was worse in patients who required more than 1 surgical resection to achieve GTR (22.4% vs 8.3%, P=.01). There was also a trend toward inferior local control with MYCN-amplified tumors or serum lactate dehydrogenase ≥1500 U/L (P=.09 and P=.06, respectively). Conclusion: After intensive chemotherapy and maximal surgical debulking, hyperfractionated RT with 21 Gy in high-risk neuroblastoma results in excellent local control. Given the young patient age, concern for late effects, and local control >90%, dose reduction may be appropriate for patients without MYCN amplification who achieve GTR.

Local Control With 21-Gy Radiation Therapy for High-Risk Neuroblastoma

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Casey, Dana L. [Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York (United States); Kushner, Brian H.; Cheung, Nai-Kong V.; Modak, Shakeel [Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York (United States); LaQuaglia, Michael P. [Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York (United States); Wolden, Suzanne L., E-mail: woldens@mskcc.org [Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York (United States)

2016-10-01

Purpose: To evaluate local control after 21-Gy radiation therapy (RT) to the primary site in patients with high-risk neuroblastoma. Methods and Materials: After receiving dose-intensive chemotherapy and gross total resection (GTR), 246 patients (aged 1.2-17.9 years, median 4.0 years) with high-risk neuroblastoma underwent RT to the primary site at Memorial Sloan Kettering from 2000 to 2014. Radiation therapy consisted of 21 Gy in twice-daily fractions of 1.5 Gy each. Local failure (LF) was correlated with biologic prognostic factors and clinical findings at the time of diagnosis and start of RT. Results: Median follow-up of surviving patients was 6.4 years. Cumulative incidence of LF was 7.1% at 2 years after RT and 9.8% at 5 years after RT. The isolated LF rate was 3.0%. Eighty-six percent of all local failures were within the RT field. Local control was worse in patients who required more than 1 surgical resection to achieve GTR (22.4% vs 8.3%, P=.01). There was also a trend toward inferior local control with MYCN-amplified tumors or serum lactate dehydrogenase ≥1500 U/L (P=.09 and P=.06, respectively). Conclusion: After intensive chemotherapy and maximal surgical debulking, hyperfractionated RT with 21 Gy in high-risk neuroblastoma results in excellent local control. Given the young patient age, concern for late effects, and local control >90%, dose reduction may be appropriate for patients without MYCN amplification who achieve GTR.

Memories of paternal relations are associated with coping and defense mechanisms in breast cancer patients: an observational study

Directory of Open Access Journals (Sweden)

Chiara Renzi

2017-11-01

Full Text Available Abstract Background Breast cancer diagnosis and treatment represent stressful events that demand emotional adjustment, thus recruiting coping strategies and defense mechanisms. As parental relations were shown to influence emotion regulation patterns and adaptive processes in adulthood, the present study investigated whether they are specifically associated to coping and defense mechanisms in patients with breast cancer. Methods One hundred and ten women hospitalized for breast cancer surgery were administered questionnaires assessing coping with cancer, defense mechanisms, and memories of parental bonding in childhood. Results High levels of paternal overprotection were associated with less mature defenses, withdrawal and fantasy and less adaptive coping mechanisms, such as hopelessness/helplessness. Low levels of paternal care were associated with a greater use of repression. No association was found between maternal care, overprotection, coping and defense mechanisms. Immature defenses correlated positively with less adaptive coping styles, while mature defenses were positively associated to a fighting spirit and to fatalism, and inversely related to less adaptive coping styles. Conclusions These data suggest that paternal relations in childhood are associated with emotional, cognitive, and behavioral regulation in adjusting to cancer immediately after surgery. Early experiences of bonding may constitute a relevant index for adaptation to cancer, indicating which patients are at risk and should be considered for psychological interventions.

Discovery of three strongly lensed quasars in the Sloan Digital Sky Survey

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Williams, P. R.; Agnello, A.; Treu, T.; Abramson, L. E.; Anguita, T.; Apostolovski, Y.; Chen, G. C.-F.; Fassnacht, C. D.; Hsueh, J. W.; Lemaux, B. C.; Motta, V.; Oldham, L.; Rojas, K.; Rusu, C. E.; Shajib, A. J.; Wang, X.

2018-06-01

We present the discovery of three quasar lenses in the Sloan Digital Sky Survey, selected using two novel photometry-based selection techniques. The J0941+0518 system, with two point sources separated by 5.46 arcsec on either side of a galaxy, has source and lens redshifts 1.54 and 0.343. Images of J2257+2349 show two point sources separated by 1.67 arcsec on either side of an E/S0 galaxy. The extracted spectra show two images of the same quasar at zs = 2.10. SDSS J1640+1045 has two quasar spectra at zs = 1.70 and fits to the SDSS and Pan-STARRS images confirm the presence of a galaxy between the two point sources. We observed 56 photometrically selected lens candidates in this follow-up campaign, confirming three new lenses, re-discovering one known lens, and ruling out 36 candidates, with 16 still inconclusive. This initial campaign demonstrates the power of purely photometric selection techniques in finding lensed quasars.

Exploring an unconventional approach to cancer

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Editorial Office

2016-08-01

biologist, Dr. Paul Lasko. “I learned how to think and design experimental approaches through the Developmental Biology classes offered by Dr. Lasko,” says Dr. Amleh appreciatively of her professor, the recipient of 2014 Prix du Québec, which is the most prestigious award attributed by the Government of Quebec in all fields of culture and science.Upon completing her doctoral degree, Dr. Amleh went on to further her career at various institutions. She became a research fellow at the Laboratory of Cellular and Developmental Biology at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK in Bethesda, Maryland, as well as a research associate at the National Institutes of Health, also in Bethesda. Additional experience in the field also boosted her expertise when she worked as an instructor at the Department of Molecular Medicine, Institute of Biotechnology, at the University of Texas Health Science Center in Houston, and a senior research scientist at the Developmental Biology Program, Memorial Sloan-Kettering Cancer Center in NY.Reflecting upon her experiences throughout her doctoral and postdoctoral research, Dr. Amleh says, “I have addressed fundamental questions related to mammalian embryonic development through a variety of projects including molecular genetics and cell culture systems.” She adds, “My ongoing and future research work plans will continue to pursue questions related to the molecular/cellular/developmental and differentiation processes.” Dr. Amleh’s research interests are focused on understand- ing the genetic control of normal and abnormal development in the mammalian system including the incidence of cancer. When discussing about the current trends in cancer research, she opined that developing rational personal/targeted therapy is very promising to develop new approaches that deal with the devastating disorder in a more effective way. “It has been suggested that personalized medicine is the right way to conquer

The Sloan Lens ACS Survey. XIII. Discovery of 40 New Galaxy-scale Strong Lenses

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Shu, Yiping; Brownstein, Joel R.; Bolton, Adam S.; Koopmans, Léon V. E.; Treu, Tommaso; Montero-Dorta, Antonio D.; Auger, Matthew W.; Czoske, Oliver; Gavazzi, Raphaël; Marshall, Philip J.; Moustakas, Leonidas A.

2017-12-01

We present the full sample of 118 galaxy-scale strong-lens candidates in the Sloan Lens ACS (SLACS) Survey for the Masses (S4TM) Survey, which are spectroscopically selected from the final data release of the Sloan Digital Sky Survey. Follow-up Hubble Space Telescope (HST) imaging observations confirm that 40 candidates are definite strong lenses with multiple lensed images. The foreground-lens galaxies are found to be early-type galaxies (ETGs) at redshifts 0.06–0.44, and background sources are emission-line galaxies at redshifts 0.22–1.29. As an extension of the SLACS Survey, the S4TM Survey is the first attempt to preferentially search for strong-lens systems with relatively lower lens masses than those in the pre-existing strong-lens samples. By fitting HST data with a singular isothermal ellipsoid model, we find that the total projected mass within the Einstein radius of the S4TM strong-lens sample ranges from 3 × 1010 M ⊙ to 2 × 1011 M ⊙. In Shu et al., we have derived the total stellar mass of the S4TM lenses to be 5 × 1010 M ⊙ to 1 × 1012 M ⊙. Both the total enclosed mass and stellar mass of the S4TM lenses are on average almost a factor of 2 smaller than those of the SLACS lenses, which also represent the typical mass scales of the current strong-lens samples. The extended mass coverage provided by the S4TM sample can enable a direct test, with the aid of strong lensing, for transitions in scaling relations, kinematic properties, mass structure, and dark-matter content trends of ETGs at intermediate-mass scales as noted in previous studies. Based on observations made with the NASA/ESA Hubble Space Telescope (HST), obtained at the Space Telescope Science Institute, which is operated by AURA, Inc., under NASA contract NAS 5-26555. These observations are associated with HST program #12210.

Validation study of a computer-based open surgical trainer: SimPraxis® simulation platform

Directory of Open Access Journals (Sweden)

Tran LN

2013-03-01

Full Text Available Linh N Tran,1 Priyanka Gupta,2 Lauren H Poniatowski,2 Shaheen Alanee,3 Marc A Dall’Era,4 Robert M Sweet21Department of Internal Medicine, Loma Linda University, Loma Linda, CA, 2Department of Urology, University of Minnesota, Minneapolis, MN, 3Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, 4Department of Urology, University of California, Davis, CA, USABackground: Technological advances have dramatically changed medical education, particularly in the era of work-hour restrictions, which increasingly highlights a need for novel methods to teach surgical skills. The purpose of this study was to evaluate the validity of a novel, computer-based, interactive, cognitive simulator for training surgeons to perform pelvic lymph node dissection (PLND.Methods: Eight prostate cancer experts evaluated the content of the simulator. Contextual aspects of the simulator were rated on a five-point Likert scale. The experts and nine first-year residents completed a simulated PLND. Time and deviations were logged, and the results were compared between experts and novices using the Mann–Whitney test.Results: Before training, 88% of the experts felt that a validated simulator would be useful for PLND training. After testing, 100% of the experts felt that it would be more useful than standard video training. Eighty-eight percent stated that they would like to see the simulator in the curriculum of residency programs and 56% thought it would be useful for accreditation purposes. The experts felt that the simulator aided in overall understanding, training indications, concepts and steps of the procedure, training how to use an assistant, and enhanced the knowledge of anatomy. Median performance times taken by experts and interns to complete a PLND procedure on the simulator were 12.62 and 23.97 minutes, respectively. Median deviation from the incorporated procedure pathway for experts was 24.5 and was 89 for novices

[Application of compression equipment using the "form memory" effect and super-elasticity of titanium nickelide in surgery for rectal cancer].

Science.gov (United States)

Vlasov, A A; Vazhenin, A V; Plotnikov, V V; Spirev, V V; Chinarev, Iu B

2010-01-01

The study is concerned with development of equipment for forming circular compression intestinal anastomosis using the "form memory" effect and super-elasticity of titanium nickelide. A sequence of technological operations is suggested, experimental tests and clinical trials carried out and immediate and end-results for anterior resection in rectal cancer are evaluated. Compression equipment for forming colorectal anastomosis proved reliable in long-term operation.

The Sloan Digital Sky Survey-II Supernova Survey: Technical Summary

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Frieman, Joshua A.; /Fermilab /KICP, Chicago /Chicago U., Astron. Astrophys. Ctr.; Bassett, Bruce; /Cape Town U. /South African Astron. Observ.; Becker, Andrew; /Washington; Choi, Changsu; /Seoul Natl. U.; Cinabro, David; /Wayne State U.; DeJongh, Don Frederic; /Fermilab; Depoy, Darren L.; /Ohio State U.; Doi, Mamoru; /Tokyo U.; Garnavich, Peter M.; /Notre Dame U.; Hogan, Craig J.; /Washington U., Seattle, Astron. Dept.; Holtzman, Jon; /New Mexico State U.; Im, Myungshin; /Seoul Natl. U.; Jha, Saurabh; /Stanford U., Phys. Dept.; Konishi, Kohki; /Tokyo U.; Lampeitl, Hubert; /Baltimore, Space Telescope Sci.; Marriner, John; /Fermilab; Marshall, Jennifer L.; /Ohio State U.; McGinnis,; /Fermilab; Miknaitis, Gajus; /Fermilab; Nichol, Robert C.; /Portsmouth U.; Prieto, Jose Luis; /Ohio State U. /Rochester Inst. Tech. /Stanford U., Phys. Dept. /Pennsylvania U.

2007-09-14

The Sloan Digital Sky Survey-II (SDSS-II) has embarked on a multi-year project to identify and measure light curves for intermediate-redshift (0.05 < z < 0.35) Type Ia supernovae (SNe Ia) using repeated five-band (ugriz) imaging over an area of 300 sq. deg. The survey region is a stripe 2.5 degrees wide centered on the celestial equator in the Southern Galactic Cap that has been imaged numerous times in earlier years, enabling construction of a deep reference image for discovery of new objects. Supernova imaging observations are being acquired between 1 September and 30 November of 2005-7. During the first two seasons, each region was imaged on average every five nights. Spectroscopic follow-up observations to determine supernova type and redshift are carried out on a large number of telescopes. In its first two three-month seasons, the survey has discovered and measured light curves for 327 spectroscopically confirmed SNe Ia, 30 probable SNe Ia, 14 confirmed SNe Ib/c, 32 confirmed SNe II, plus a large number of photometrically identified SNe Ia, 94 of which have host-galaxy spectra taken so far. This paper provides an overview of the project and briefly describes the observations completed during the first two seasons of operation.

Reactivation of CDX2 in Gastric Cancer as Mark for Gene Silencing Memory

International Nuclear Information System (INIS)

Kameoka, Yuri; Kitazawa, Riko; Ariasu, Kanazu; Tachibana, Ryosuke; Mizuno, Yosuke; Haraguchi, Ryuma; Kitazawa, Sohei

2015-01-01

To explore the epigenetic mechanism that reactivates CDX2 (a homeobox transcription factor that serves as a tumor-suppressor gene) in intestinal-type gastric cancer during cancer progression, we examined the methylation status of the CDX2 gene promoter and the expression pattern of methyl-CpG binding protein-2 (MeCP2). From archives of the pathology records of surgically excised advanced stomach cancer cases in the Department of Molecular Pathology, Ehime University in a past decate (n=265), 10 cases of intestinal-type tubular adenocarcinoma, well-differentiated type (wel) with minor poorly-differentiated adenocarcinoma (por) components were selected. The expression pattern of CDX2, MUC2 and MeCP2 in these 10 cases was analyzed by immunohistochemistry. The cancerous and non-cancerous areas were selectively obtained by microdissection, and the methylation status of the CDX2 promoter of each area was assessed by methylation-specific polymerase chain reaction (MSP). In all 10 cases, CDX2 expression was clearly observed in the nucleus of the non-cancerous background of the intestinal metaplasic area, where the unmethylation pattern of the CDX2 gene promoter prevailed with reduced MeCP2 expression. In this metaplastic area, CDX2 expression was co-localized with its target gene, MUC2. CDX2 expression then disappeared from the deep invasive wel area. Reflecting the reduced CDX2 expression, microdissected samples from all the wel areas showed hypermethylation of the CDX2 gene promoter by MSP, with prominent MeCP2 expression. Interestingly, while hypermethylation of the CDX2 gene promoter was maintained in the por area in 8 of the 10 cases, CDX2 expression was restored in por areas where MeCP2 expression was markedly and selectively reduced. The other two cases, however, showed a constant MeCP2 expression level comparable to the surrounding deep invasive wel area with negative CDX2 expression. Therefore, gene silencing by hypermethylation may be overcome by the reduction of

DISTRIBUTION OF MAXIMAL LUMINOSITY OF GALAXIES IN THE SLOAN DIGITAL SKY SURVEY

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Taghizadeh-Popp, M.; Szalay, A. S. [Department of Physics and Astronomy, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 (United States); Ozogany, K.; Racz, Z. [Institute for Theoretical Physics-HAS, Eoetvoes University, Pazmany setany 1/a, 1117 Budapest (Hungary); Regoes, E., E-mail: mtaghiza@pha.jhu.edu [European Laboratory for Particle Physics (CERN), Geneva (Switzerland)

2012-11-10

Extreme value statistics is applied to the distribution of galaxy luminosities in the Sloan Digital Sky Survey. We analyze the DR8 Main Galaxy Sample (MGS), as well as the luminous red galaxies (LRGs). Maximal luminosities are sampled from batches consisting of elongated pencil beams in the radial direction of sight. For the MGS, results suggest a small and positive tail index {xi}, effectively ruling out the possibility of having a finite maximum cutoff luminosity, and implying that the luminosity distribution function may decay as a power law at the high-luminosity end. Assuming, however, {xi} = 0, a non-parametric comparison of the maximal luminosities with the Fisher-Tippett-Gumbel distribution (limit distribution for variables distributed by the Schechter fit) indicates a good agreement provided that uncertainties arising from both the finite batch size and the batch-size distribution are accounted for. For a volume-limited sample of LRGs, results show that they can be described as being the extremes of a luminosity distribution with an exponentially decaying tail, provided that the uncertainties related to batch-size distribution are taken care of.

A deep proper motion catalog within the Sloan digital sky survey footprint

International Nuclear Information System (INIS)

Munn, Jeffrey A.; Harris, Hugh C.; Tilleman, Trudy M.; Hippel, Ted von; Kilic, Mukremin; Liebert, James W.; Williams, Kurtis A.; DeGenarro, Steven; Jeffery, Elizabeth

2014-01-01

A new proper motion catalog is presented, combining the Sloan Digital Sky Survey (SDSS) with second epoch observations in the r band within a portion of the SDSS imaging footprint. The new observations were obtained with the 90prime camera on the Steward Observatory Bok 90 inch telescope, and the Array Camera on the U.S. Naval Observatory, Flagstaff Station, 1.3 m telescope. The catalog covers 1098 square degrees to r = 22.0, an additional 1521 square degrees to r = 20.9, plus a further 488 square degrees of lesser quality data. Statistical errors in the proper motions range from 5 mas year −1 at the bright end to 15 mas year −1 at the faint end, for a typical epoch difference of six years. Systematic errors are estimated to be roughly 1 mas year −1 for the Array Camera data, and as much as 2–4 mas year −1 for the 90prime data (though typically less). The catalog also includes a second epoch of r band photometry.

A deep proper motion catalog within the Sloan digital sky survey footprint

Energy Technology Data Exchange (ETDEWEB)

Munn, Jeffrey A.; Harris, Hugh C.; Tilleman, Trudy M. [US Naval Observatory, Flagstaff Station, 10391 West Naval Observatory Road, Flagstaff, AZ 86005-8521 (United States); Hippel, Ted von [Embry-Riddle Aeronautical University, Physical Sciences, 600 South Clyde Morris Boulevard Daytona Beach, FL 32114-3900 (United States); Kilic, Mukremin [University of Oklahoma, Homer L. Dodge Department of Physics and Astronomy, 440 West Brooks Street, Norman, OK 73019 (United States); Liebert, James W. [University of Arizona, Steward Observatory, Tucson, AZ 85721 (United States); Williams, Kurtis A. [Department of Physics and Astronomy, Texas A and M University-Commerce, P.O. Box 3011, Commerce, TX 75429 (United States); DeGenarro, Steven [Department of Astronomy, University of Texas at Austin, 1 University Station C1400, Austin, TX 78712-0259 (United States); Jeffery, Elizabeth, E-mail: jam@nofs.navy.mil, E-mail: hch@nofs.navy.mil, E-mail: trudy@nofs.navy.mil, E-mail: ted.vonhippel@erau.edu, E-mail: kilic@ou.edu, E-mail: jamesliebert@gmail.com, E-mail: kurtis.williams@tamuc.edu, E-mail: studiofortytwo@yahoo.com, E-mail: ejeffery@byu.edu [BYU Department of Physics and Astronomy, N283 ESC, Provo, UT 84602 (United States)

2014-12-01

A new proper motion catalog is presented, combining the Sloan Digital Sky Survey (SDSS) with second epoch observations in the r band within a portion of the SDSS imaging footprint. The new observations were obtained with the 90prime camera on the Steward Observatory Bok 90 inch telescope, and the Array Camera on the U.S. Naval Observatory, Flagstaff Station, 1.3 m telescope. The catalog covers 1098 square degrees to r = 22.0, an additional 1521 square degrees to r = 20.9, plus a further 488 square degrees of lesser quality data. Statistical errors in the proper motions range from 5 mas year{sup −1} at the bright end to 15 mas year{sup −1} at the faint end, for a typical epoch difference of six years. Systematic errors are estimated to be roughly 1 mas year{sup −1} for the Array Camera data, and as much as 2–4 mas year{sup −1} for the 90prime data (though typically less). The catalog also includes a second epoch of r band photometry.

GALAXY ZOO MORPHOLOGY AND PHOTOMETRIC REDSHIFTS IN THE SLOAN DIGITAL SKY SURVEY

International Nuclear Information System (INIS)

Way, M. J.

2011-01-01

It has recently been demonstrated that one can accurately derive galaxy morphology from particular primary and secondary isophotal shape estimates in the Sloan Digital Sky Survey (SDSS) imaging catalog. This was accomplished by applying Machine Learning techniques to the Galaxy Zoo morphology catalog. Using the broad bandpass photometry of the SDSS in combination with precise knowledge of galaxy morphology should help in estimating more accurate photometric redshifts for galaxies. Using the Galaxy Zoo separation for spirals and ellipticals in combination with SDSS photometry we attempt to calculate photometric redshifts. In the best case we find that the root-mean-square error for luminous red galaxies classified as ellipticals is as low as 0.0118. Given these promising results we believe better photometric redshift estimates for all galaxies in the SDSS (∼350 million) will be feasible if researchers can also leverage their derived morphologies via Machine Learning. These initial results look to be promising for those interested in estimating weak lensing, baryonic acoustic oscillation, and other fields dependent upon accurate photometric redshifts.

CHARACTERIZATION OF SLOAN DIGITAL SKY SURVEY STELLAR PHOTOMETRY

International Nuclear Information System (INIS)

Fukugita, Masataka; Yasuda, Naoki; Doi, Mamoru; Gunn, James E.; York, Donald G.

2011-01-01

We study the photometric properties of stars in the data archive of the Sloan Digital Sky Survey (SDSS), the prime aim being to understand the photometric calibration over the entire data set. It is confirmed that the photometric calibration of point sources is accurately on the system defined by the SDSS standard stars. We have also confirmed that the photometric synthesis of the SDSS spectrophotometric data gives broadband fluxes that agree with the photometry with errors of no more than 0.04 mag and little systematic tilt with wavelength. This verifies that the response functions of the 2.5 m telescope system are well characterized. We locate stars in the SDSS photometric system, so that stars can roughly be classified into spectral classes from the color information. We show how metallicity and surface gravity affect colors, and that stars contained in the SDSS general catalog, plotted in color space, show a distribution that matches well with what is anticipated from the variations of metallicity and surface gravity. The color-color plots are perfectly consistent among the three samples-stars in the SDSS general catalog, SDSS standard stars, and spectrophotometric stars of Gunn and Stryker-especially when some considerations are taken into account of the differences (primarily metallicity) of the samples. We show that the g - r-inverse temperature relation is tight and can be used as a good estimator of the effective temperature of stars over a fairly wide range of effective temperatures. We also confirm that the colors of G2V stars in the SDSS photometric system match well with the Sun.

Results from a Pilot REU Program: Exploring the Cosmos Using Sloan Digital Sky Survey Data

Science.gov (United States)

Chanover, Nancy J.; Holley-Bockelmann, Kelly; Holtzman, Jon A.

2017-01-01

In the Summer of 2016 we conducted a 10-week pilot Research Experience for Undergraduates (REU) program aimed at increasing the participation of underrepresented minority undergraduate students in research using data from the Sloan Digital Sky Survey (SDSS). This program utilized a distributed REU model, whereby students worked with SDSS scientists on exciting research projects while serving as members of a geographically distributed research community. The format of this REU is similar to that of the SDSS collaboration itself, and since this collaboration structure has become a model for the next generation of large scale astronomical surveys, the students participating in the SDSS REU received early exposure and familiarity with this approach to collaborative scientific research. The SDSS REU also provided the participants with a low-risk opportunity to audition for graduate schools and to explore opportunities afforded by a career as a research scientist. The six student participants were placed at SDSS REU host sites at the Center for Astrophysics at Harvard University, University of Wisconsin-Madison, Vanderbilt University, and the University of Portsmouth. Their research projects covered a broad range of topics related to stars, galaxies, and quasars, all making use of SDSS data. At the start of the summer the REU students participated in a week-long Boot Camp at NMSU, which served as a program orientation, an introduction to skills relevant to their research projects, and an opportunity for team-building and cohort-forming. To foster a sense of community among our distributed students throughout the summer, we conducted a weekly online meeting for all students in the program via virtual meeting tools. These virtual group meetings served two purposes: as a weekly check-in to find out how their projects were progressing, and to conduct professional development seminars on topics of interest and relevance to the REU participants. We discuss the outcomes of this

Modulating epigenetic memory through vitamins and TET: implications for regenerative medicine and cancer treatment.

Science.gov (United States)

Hore, Timothy A

2017-06-01

Vitamins A and C represent unrelated sets of small molecules that are essential to the human diet and have recently been shown to intensify erasure of epigenetic memory in naive embryonic stem cells. These effects are driven by complementary enhancement of the ten-eleven translocation (TET) demethylases - vitamin A stimulates TET expression, whereas vitamin C potentiates TET catalytic activity. Vitamin A and C cosupplementation synergistically enhances reprogramming of differentiated cells to the naive state, but overuse may exaggerate instability of imprinted genes. As such, optimizing their use in culture media will be important for regenerative medicine and mammalian transgenics. In addition, mechanistic perception of how these vitamins interact with the epigenome may be relevant for understanding cancer and improving patient treatment.

Continuing Long Term Optical and Infrared Reverberation Mapping of 17 Sloan Digital Sky Survey Quasars

Science.gov (United States)

Gorjian, Varoujan; Barth, Aaron; Brandt, Niel; Dawson, Kyle; Green, Paul; Ho, Luis; Horne, Keith; Jiang, Linhua; McGreer, Ian; Schneider, Donald; Shen, Yue; Tao, Charling

2018-05-01

Previous Spitzer reverberation monitoring projects searching for UV/optical light absorbed and re-emitted in the IR by dust have been limited to low luminosity active galactic nuclei (AGN) that could potentially show reverberation within a single cycle ( 1 year). Cycle 11-12's two year baseline allowed for the reverberation mapping of 17 high-luminosity quasars from the Sloan Digital Sky Survey Reverberation Mapping project. We continued this monitoring in Cycle 13 and now propose to extend this program in Cycle 14. By combining ground-based monitoring from Pan-STARRS, CFHT, and Steward Observatory telescopes with Spitzer data we have for the first time detected dust reverberation in quasars. By continuing observations with this unqiue combination of resources we should detect reverberation in more objects and reduce the uncertainties for the remaining sources.

Axitinib for preoperative downstaging of renal cell carcinoma with sarcomatoid differentiation and direct invasion of the duodenum and inferior vena cava: a case report

Directory of Open Access Journals (Sweden)

Yuki H

2014-02-01

Full Text Available Hideo Yuki,1,* Takao Kamai,1,* Keiichi Kubota,2 Hideyuki Abe,1 Daisaku Nishihara,1 Tomoya Mizuno,1 Akinori Masuda,1 Hironori Betsunoh,1 Masahiro Yashi,1 Yoshitatsu Fukabori,1 Ken-Ichiro Yoshida1 1Department of Urology, 2Department of Gastroenterological Surgery, Dokkyo Medical University, Mibu, Tochigi, Japan *These authors contributed equally to this manuscript Background: Renal cell carcinoma (RCC with sarcomatoid differentiation is invasive, refractory to treatment, and has a higher mortality. Therefore, systemic therapy is still challenging, and the curative resection of localized or locally advanced RCC with sarcomatoid differentiation is very important. Axitinib is a potent and selective second-generation vascular endothelial growth factor receptor tyrosine kinase inhibitor with improved safety and tolerability. Axitinib is generally recommended as second-line therapy for advanced RCC because the phase III axitinib versus sorafenib in advanced RCC (AXIS trial demonstrated that it achieved longer progression-free survival than sorafenib in patients with metastatic RCC after failure of an approved first-line regimen. Methods: We present a 73-year-old man who had a large (13 cm in diameter right RCC with sarcomatoid differentiation that directly invaded the duodenum and inferior vena cava. The patient presented with gastrointestinal bleeding, was unable to eat solid food, and had become emaciated. Thus, his classification was poor risk with anemia, hypercalcemia, and poor performance status, according to the Memorial Sloan-Kettering Cancer Center criteria. He seemed unlikely to survive if radical nephrectomy, cavotomy with thrombectomy, and pancreatoduodenectomy were performed. To reduce the tumor burden and potential operative complications, we administered axitinib as first-line neoadjuvant therapy. Results: Six weeks of treatment reduced the tumor burden without causing severe toxicities. Subsequently, radical right nephrectomy, cavotomy

Patterns of Failure for Rhabdomyosarcoma of the Perineal and Perianal Region

International Nuclear Information System (INIS)

Casey, Dana L.; Wexler, Leonard H.; LaQuaglia, Michael P.; Meyers, Paul A.; Wolden, Suzanne L.

2014-01-01

Purpose: To analyze prognostic factors and patterns of failure for rhabdomyosarcoma of the perineal and perianal region (PRMS), with an emphasis on radiation therapy for locoregional control. Methods and Materials: Detailed records of all 14 patients treated for PRMS at Memorial Sloan-Kettering Cancer Center between 1998 and 2012 were reviewed. The Kaplan-Meier method was used to assess the event-free survival (EFS) and overall survival (OS), and a competing-risks analysis was used to assess the cumulative incidence of local, regional, and distant failures. Results: Median age was 15.8 years (range, 1.1-31.9 years). High-risk features were identified: 9 of 14 patients (64%) had group 3 disease and 3 of 14 (21%) had group 4; 11 of 14 tumors (78%) were alveolar; 12 of 14 tumors (86%) were ≥5 cm; and 9 of 14 patients (64%) had involved lymph nodes (N1). Of those aged ≥10 years at diagnosis, 9 of 10 (90%) had alveolar histology, all had tumors ≥5 cm, and 8 of 10 (80%) presented with N1 disease. The rates of local, regional, and distant failure at 5 years were 17%, 31%, and 52%, respectively. Although 3 of the 4 patients with regional failure received nodal irradiation, only one of the nodal failures occurred in the radiation therapy field. The 5-year EFS was 33%, and OS was 39%. Age ≥10 years was associated with poor outcomes: EFS was 13% in patients aged ≥10 years, compared with 75% in those aged <10 years (P=.04); the OS was 13% in patients aged ≥10 years, compared with 100% in those aged <10 years (P=.04). Conclusions: Patients with PRMS, especially those aged ≥10 years, present with poor prognostic features and continue to have poor outcomes. Given the high incidence of regional node recurrence, we recommend prophylactic ilioinguinal lymph node irradiation for all patients aged ≥10 years. For children aged <10 years, nodal evaluation is essential to determine the role for lymph node irradiation

International travel patterns and travel risks for stem cell transplant recipients.

Science.gov (United States)

Mikati, Tarek; Griffin, Kenneth; Lane, Dakotah; Matasar, Matthew; Shah, Monika K

2015-01-01

Stem cell transplantation (SCT) is being increasingly utilized for multiple medical illnesses. However, there is limited knowledge about international travel patterns and travel-related illnesses of stem cell transplant recipients (SCTRs). An observational cross-sectional study was conducted among 979 SCTRs at Memorial Sloan Kettering Cancer Center using a previously standardized and validated questionnaire. International travel post SCT, pre-travel health advice, exposure risks, and travel-related illnesses were queried. A total of 516 SCTRs completed the survey (55% response rate); of these, 40% were allogeneic SCTRs. A total of 229 (44.3%) respondents reported international travel outside the United States and Canada post SCT. The international travel incidence was 32% [95% confidence interval CI 28-36] within 2 years after SCT. Using multivariable Cox regression analysis, variables significantly associated with international travel within first 2 years after SCT were history of international travel prior to SCT [hazard ratio (HR) = 5.3, 95% CI 2.3-12.0], autologous SCT (HR = 2.6, 95% CI 1.6-2.8), foreign birth (HR = 2.3, 95% CI 1.5-3.3), and high income (HR = 2.0, 95% CI 1.8-3.7). During their first trip, 64 travelers (28%) had traveled to destinations that may have required vaccination or malaria chemoprophylaxis. Only 56% reported seeking pre-travel health advice. Of those who traveled, 16 travelers (7%) became ill enough to require medical attention during their first trip after SCT. Ill travelers were more likely to have visited high-risk areas (60 vs 26%, p = 0.005), to have had a longer mean trip duration (24 vs 12 days, p = 0.0002), and to have visited friends and relatives (69 vs 21%, p travel was common among SCTRs within 2 years after SCT and was mainly to low-risk destinations. Although the overall incidence of travel-related illnesses was low, certain subgroups of travelers were at a significantly higher risk. Pre

The core competencies of James Marion Sims, MD.

Science.gov (United States)

Straughn, J Michael; Gandy, Roy E; Rodning, Charles B

2012-07-01

The concept of core competencies in graduate medical education was introduced by the Accreditation Council for Graduate Medical Education of the American Medical Association to semiquantitatively assess the professional performance of students, residents, practitioners, and faculty. Many aspects of the career of J. Marion Sims, MD, are exemplary of those core competencies: MEDICAL KNOWLEDGE: Author of the first American textbook related to gynecology. MEDICAL CARE: Innovator of the Sims' Vaginal Speculum, Sims' Position, Sims' Test, and vesico-/rectovaginal fistulorrhaphy; advocated abdominal exploration for penetrating wounds; performed the first cholecystostomy. PROFESSIONALISM: Served as President of the New York Academy of Medicine, the American Medical Association, and the American Gynecologic Society. INTERPERSONAL RELATIONSHIPS/COMMUNICATION: Cared for the indigent, hearthless, indentured, disenfranchised; served as consulting surgeon to the Empress Eugénie (France), the Duchess of Hamilton (Scotland), the Empress of Austria, and other royalty of the aristocratic Houses of Europe; accorded the National Order of the Legion of Honor. PRACTICE-BASED LEARNING: Introduction of silver wire sutures; adoption of the principles of asepsis/antisepsis; adoption of the principles of general anesthesia. SYSTEMS-BASED PRACTICE: Established the Woman's Hospital, New York City, New York, the predecessor of the Memorial Sloan-Kettering Center for the Treatment of Cancer and Allied Diseases; organized the Anglo-American Ambulance Corps under the patronage of Napoleon III. What led him to a life of clinical and humanitarian service? First, he was determined to succeed. His formal medical/surgical education was perhaps the best available to North Americans during that era. Second, he was courageous in experimentation and innovation, applying new developments in operative technique, asepsis/antisepsis, and general anesthesia. Third, his curiosity was not burdened by rigid

Tumour cell lysate-loaded dendritic cell vaccine induces biochemical and memory immune response in castration-resistant prostate cancer patients.

Science.gov (United States)

Reyes, D; Salazar, L; Espinoza, E; Pereda, C; Castellón, E; Valdevenito, R; Huidobro, C; Inés Becker, M; Lladser, A; López, M N; Salazar-Onfray, F

2013-09-17

Recently, we produced a tumour antigen-presenting cells (TAPCells) vaccine using a melanoma cell lysate, called TRIMEL, as an antigen source and an activation factor. Tumour antigen-presenting cells induced immunological responses and increased melanoma patient survival. Herein, we investigated the effect of TAPCells loaded with prostate cancer cell lysates (PCCL) as an antigen source, and TRIMEL as a dendritic cell (DC) activation factor; which were co-injected with the Concholepas concholepas haemocyanin (CCH) as an adjuvant on castration-resistant prostate cancer (CRPC) patients. The lysate mix capacity, for inducing T-cell activation, was analysed by flow cytometry and Elispot. Delayed-type hypersensitivity (DTH) reaction against PCCL, frequency of CD8(+) memory T cells (Tm) in blood and prostate-specific antigen (PSA) levels in serum were measured in treated patients. The lysate mix induced functional mature DCs that were capable of activating PCCL-specific T cells. No relevant adverse reactions were observed. Six out of 14 patients showed a significant decrease in levels of PSA. DTH(+) patients showed a prolonged PSA doubling-time after treatment. Expansion of functional central and effector CD8(+) Tm were detected. Treatment of CRPC patients with lysate-loaded TAPCells and CCH as an adjuvant is safe: generating biochemical and memory immune responses. However, the limited number of cases requires confirmation in a phase II clinical trial.

XMM-NEWTON AND OPTICAL OBSERVATIONS OF CATACLYSMIC VARIABLES FROM THE SLOAN DIGITAL SKY SURVEY

International Nuclear Information System (INIS)

Hilton, Eric J.; Szkody, Paula; Mukadam, Anjum; Henden, Arne; Dillon, William; Schmidt, Gary D.

2009-01-01

We report on XMM-Newton and optical results for six cataclysmic variables that were selected from Sloan Digital Sky Survey (SDSS) spectra because they showed strong He II emission lines, indicative of being candidates for containing white dwarfs with strong magnetic fields. While high X-ray background rates prevented optimum results, we are able to confirm SDSS J233325.92+152222.1 as an intermediate polar from its strong pulse signature at 21 minutes and its obscured hard X-ray spectrum. Ground-based circular polarization and photometric observations were also able to confirm SDSS J142256.31 - 022108.1 as a polar with a period near 4 hr. Photometry of SDSS J083751.00+383012.5 and SDSS J093214.82+495054.7 solidifies the orbital period of the former as 3.18 hr and confirms the latter as a high-inclination system with deep eclipses.

THE ELEVENTH AND TWELFTH DATA RELEASES OF THE SLOAN DIGITAL SKY SURVEY: FINAL DATA FROM SDSS-III

International Nuclear Information System (INIS)

Alam, Shadab; Albareti, Franco D.; Prieto, Carlos Allende; Anders, F.; Anderson, Scott F.; Anderton, Timothy; Andrews, Brett H.; Armengaud, Eric; Aubourg, Éric; Bautista, Julian E.; Bailey, Stephen; Basu, Sarbani; Beaton, Rachael L.; Beers, Timothy C.

2015-01-01

The third generation of the Sloan Digital Sky Survey (SDSS-III) took data from 2008 to 2014 using the original SDSS wide-field imager, the original and an upgraded multi-object fiber-fed optical spectrograph, a new near-infrared high-resolution spectrograph, and a novel optical interferometer. All of the data from SDSS-III are now made public. In particular, this paper describes Data Release 11 (DR11) including all data acquired through 2013 July, and Data Release 12 (DR12) adding data acquired through 2014 July (including all data included in previous data releases), marking the end of SDSS-III observing. Relative to our previous public release (DR10), DR12 adds one million new spectra of galaxies and quasars from the Baryon Oscillation Spectroscopic Survey (BOSS) over an additional 3000 deg 2 of sky, more than triples the number of H-band spectra of stars as part of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE), and includes repeated accurate radial velocity measurements of 5500 stars from the Multi-object APO Radial Velocity Exoplanet Large-area Survey (MARVELS). The APOGEE outputs now include the measured abundances of 15 different elements for each star. In total, SDSS-III added 5200 deg 2 of ugriz imaging; 155,520 spectra of 138,099 stars as part of the Sloan Exploration of Galactic Understanding and Evolution 2 (SEGUE-2) survey; 2,497,484 BOSS spectra of 1,372,737 galaxies, 294,512 quasars, and 247,216 stars over 9376 deg 2 ; 618,080 APOGEE spectra of 156,593 stars; and 197,040 MARVELS spectra of 5513 stars. Since its first light in 1998, SDSS has imaged over 1/3 of the Celestial sphere in five bands and obtained over five million astronomical spectra

The Eleventh and Twelfth Data Releases of the Sloan Digital Sky Survey: Final Data from SDSS-III

Science.gov (United States)

Alam, Shadab; Albareti, Franco D.; Allende Prieto, Carlos; Anders, F.; Anderson, Scott F.; Anderton, Timothy; Andrews, Brett H.; Armengaud, Eric; Aubourg, Éric; Bailey, Stephen; Basu, Sarbani; Bautista, Julian E.; Beaton, Rachael L.; Beers, Timothy C.; Bender, Chad F.; Berlind, Andreas A.; Beutler, Florian; Bhardwaj, Vaishali; Bird, Jonathan C.; Bizyaev, Dmitry; Blake, Cullen H.; Blanton, Michael R.; Blomqvist, Michael; Bochanski, John J.; Bolton, Adam S.; Bovy, Jo; Shelden Bradley, A.; Brandt, W. N.; Brauer, D. E.; Brinkmann, J.; Brown, Peter J.; Brownstein, Joel R.; Burden, Angela; Burtin, Etienne; Busca, Nicolás G.; Cai, Zheng; Capozzi, Diego; Carnero Rosell, Aurelio; Carr, Michael A.; Carrera, Ricardo; Chambers, K. C.; Chaplin, William James; Chen, Yen-Chi; Chiappini, Cristina; Chojnowski, S. Drew; Chuang, Chia-Hsun; Clerc, Nicolas; Comparat, Johan; Covey, Kevin; Croft, Rupert A. C.; Cuesta, Antonio J.; Cunha, Katia; da Costa, Luiz N.; Da Rio, Nicola; Davenport, James R. A.; Dawson, Kyle S.; De Lee, Nathan; Delubac, Timothée; Deshpande, Rohit; Dhital, Saurav; Dutra-Ferreira, Letícia; Dwelly, Tom; Ealet, Anne; Ebelke, Garrett L.; Edmondson, Edward M.; Eisenstein, Daniel J.; Ellsworth, Tristan; Elsworth, Yvonne; Epstein, Courtney R.; Eracleous, Michael; Escoffier, Stephanie; Esposito, Massimiliano; Evans, Michael L.; Fan, Xiaohui; Fernández-Alvar, Emma; Feuillet, Diane; Filiz Ak, Nurten; Finley, Hayley; Finoguenov, Alexis; Flaherty, Kevin; Fleming, Scott W.; Font-Ribera, Andreu; Foster, Jonathan; Frinchaboy, Peter M.; Galbraith-Frew, J. G.; García, Rafael A.; García-Hernández, D. A.; García Pérez, Ana E.; Gaulme, Patrick; Ge, Jian; Génova-Santos, R.; Georgakakis, A.; Ghezzi, Luan; Gillespie, Bruce A.; Girardi, Léo; Goddard, Daniel; Gontcho, Satya Gontcho A.; González Hernández, Jonay I.; Grebel, Eva K.; Green, Paul J.; Grieb, Jan Niklas; Grieves, Nolan; Gunn, James E.; Guo, Hong; Harding, Paul; Hasselquist, Sten; Hawley, Suzanne L.; Hayden, Michael; Hearty, Fred R.; Hekker, Saskia; Ho, Shirley; Hogg, David W.; Holley-Bockelmann, Kelly; Holtzman, Jon A.; Honscheid, Klaus; Huber, Daniel; Huehnerhoff, Joseph; Ivans, Inese I.; Jiang, Linhua; Johnson, Jennifer A.; Kinemuchi, Karen; Kirkby, David; Kitaura, Francisco; Klaene, Mark A.; Knapp, Gillian R.; Kneib, Jean-Paul; Koenig, Xavier P.; Lam, Charles R.; Lan, Ting-Wen; Lang, Dustin; Laurent, Pierre; Le Goff, Jean-Marc; Leauthaud, Alexie; Lee, Khee-Gan; Lee, Young Sun; Licquia, Timothy C.; Liu, Jian; Long, Daniel C.; López-Corredoira, Martín; Lorenzo-Oliveira, Diego; Lucatello, Sara; Lundgren, Britt; Lupton, Robert H.; Mack, Claude E., III; Mahadevan, Suvrath; Maia, Marcio A. G.; Majewski, Steven R.; Malanushenko, Elena; Malanushenko, Viktor; Manchado, A.; Manera, Marc; Mao, Qingqing; Maraston, Claudia; Marchwinski, Robert C.; Margala, Daniel; Martell, Sarah L.; Martig, Marie; Masters, Karen L.; Mathur, Savita; McBride, Cameron K.; McGehee, Peregrine M.; McGreer, Ian D.; McMahon, Richard G.; Ménard, Brice; Menzel, Marie-Luise; Merloni, Andrea; Mészáros, Szabolcs; Miller, Adam A.; Miralda-Escudé, Jordi; Miyatake, Hironao; Montero-Dorta, Antonio D.; More, Surhud; Morganson, Eric; Morice-Atkinson, Xan; Morrison, Heather L.; Mosser, Benôit; Muna, Demitri; Myers, Adam D.; Nandra, Kirpal; Newman, Jeffrey A.; Neyrinck, Mark; Nguyen, Duy Cuong; Nichol, Robert C.; Nidever, David L.; Noterdaeme, Pasquier; Nuza, Sebastián E.; O'Connell, Julia E.; O'Connell, Robert W.; O'Connell, Ross; Ogando, Ricardo L. C.; Olmstead, Matthew D.; Oravetz, Audrey E.; Oravetz, Daniel J.; Osumi, Keisuke; Owen, Russell; Padgett, Deborah L.; Padmanabhan, Nikhil; Paegert, Martin; Palanque-Delabrouille, Nathalie; Pan, Kaike; Parejko, John K.; Pâris, Isabelle; Park, Changbom; Pattarakijwanich, Petchara; Pellejero-Ibanez, M.; Pepper, Joshua; Percival, Will J.; Pérez-Fournon, Ismael; P´rez-Ra`fols, Ignasi; Petitjean, Patrick; Pieri, Matthew M.; Pinsonneault, Marc H.; Porto de Mello, Gustavo F.; Prada, Francisco; Prakash, Abhishek; Price-Whelan, Adrian M.; Protopapas, Pavlos; Raddick, M. Jordan; Rahman, Mubdi; Reid, Beth A.; Rich, James; Rix, Hans-Walter; Robin, Annie C.; Rockosi, Constance M.; Rodrigues, Thaíse S.; Rodríguez-Torres, Sergio; Roe, Natalie A.; Ross, Ashley J.; Ross, Nicholas P.; Rossi, Graziano; Ruan, John J.; Rubiño-Martín, J. A.; Rykoff, Eli S.; Salazar-Albornoz, Salvador; Salvato, Mara; Samushia, Lado; Sánchez, Ariel G.; Santiago, Basílio; Sayres, Conor; Schiavon, Ricardo P.; Schlegel, David J.; Schmidt, Sarah J.; Schneider, Donald P.; Schultheis, Mathias; Schwope, Axel D.; Scóccola, C. G.; Scott, Caroline; Sellgren, Kris; Seo, Hee-Jong; Serenelli, Aldo; Shane, Neville; Shen, Yue; Shetrone, Matthew; Shu, Yiping; Silva Aguirre, V.; Sivarani, Thirupathi; Skrutskie, M. F.; Slosar, Anže; Smith, Verne V.; Sobreira, Flávia; Souto, Diogo; Stassun, Keivan G.; Steinmetz, Matthias; Stello, Dennis; Strauss, Michael A.; Streblyanska, Alina; Suzuki, Nao; Swanson, Molly E. C.; Tan, Jonathan C.; Tayar, Jamie; Terrien, Ryan C.; Thakar, Aniruddha R.; Thomas, Daniel; Thomas, Neil; Thompson, Benjamin A.; Tinker, Jeremy L.; Tojeiro, Rita; Troup, Nicholas W.; Vargas-Magaña, Mariana; Vazquez, Jose A.; Verde, Licia; Viel, Matteo; Vogt, Nicole P.; Wake, David A.; Wang, Ji; Weaver, Benjamin A.; Weinberg, David H.; Weiner, Benjamin J.; White, Martin; Wilson, John C.; Wisniewski, John P.; Wood-Vasey, W. M.; Ye`che, Christophe; York, Donald G.; Zakamska, Nadia L.; Zamora, O.; Zasowski, Gail; Zehavi, Idit; Zhao, Gong-Bo; Zheng, Zheng; Zhou, Xu; Zhou, Zhimin; Zou, Hu; Zhu, Guangtun

2015-07-01

The third generation of the Sloan Digital Sky Survey (SDSS-III) took data from 2008 to 2014 using the original SDSS wide-field imager, the original and an upgraded multi-object fiber-fed optical spectrograph, a new near-infrared high-resolution spectrograph, and a novel optical interferometer. All of the data from SDSS-III are now made public. In particular, this paper describes Data Release 11 (DR11) including all data acquired through 2013 July, and Data Release 12 (DR12) adding data acquired through 2014 July (including all data included in previous data releases), marking the end of SDSS-III observing. Relative to our previous public release (DR10), DR12 adds one million new spectra of galaxies and quasars from the Baryon Oscillation Spectroscopic Survey (BOSS) over an additional 3000 deg2 of sky, more than triples the number of H-band spectra of stars as part of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE), and includes repeated accurate radial velocity measurements of 5500 stars from the Multi-object APO Radial Velocity Exoplanet Large-area Survey (MARVELS). The APOGEE outputs now include the measured abundances of 15 different elements for each star. In total, SDSS-III added 5200 deg2 of ugriz imaging; 155,520 spectra of 138,099 stars as part of the Sloan Exploration of Galactic Understanding and Evolution 2 (SEGUE-2) survey; 2,497,484 BOSS spectra of 1,372,737 galaxies, 294,512 quasars, and 247,216 stars over 9376 deg2; 618,080 APOGEE spectra of 156,593 stars; and 197,040 MARVELS spectra of 5513 stars. Since its first light in 1998, SDSS has imaged over 1/3 of the Celestial sphere in five bands and obtained over five million astronomical spectra.

The eleventh and twelfth data release of the Sloan Digital Sky Survey: Final data from SDSS-III

Energy Technology Data Exchange (ETDEWEB)

Alam, Shadab; Albareti, Franco D.; Prieto, Carlos Allende; Anders, F.; Anderson, Scott F.; Anderton, Timothy; Andrews, Brett H.; Armengaud, Eric; Aubourg, Éric; Bailey, Stephen; Basu, Sarbani; Bautista, Julian E.; Beaton, Rachael L.; Beers, Timothy C.; Bender, Chad F.; Berlind, Andreas A.; Beutler, Florian; Bhardwaj, Vaishali; Bird, Jonathan C.; Bizyaev, Dmitry; Blake, Cullen H.; Blanton, Michael R.; Blomqvist, Michael; Bochanski, John J.; Bolton, Adam S.; Bovy, Jo; Bradley, A. Shelden; Brandt, W. N.; Brauer, D. E.; Brinkmann, J.; Brown, Peter J.; Brownstein, Joel R.; Burden, Angela; Burtin, Etienne; Busca, Nicolás G.; Cai, Zheng; Capozzi, Diego; Rosell, Aurelio Carnero; Carr, Michael A.; Carrera, Ricardo; Chambers, K. C.; Chaplin, William James; Chen, Yen-Chi; Chiappini, Cristina; Chojnowski, S. Drew; Chuang, Chia-Hsun; Clerc, Nicolas; Comparat, Johan; Covey, Kevin; Croft, Rupert A. C.; Cuesta, Antonio J.; Cunha, Katia; Costa, Luiz N. da; Rio, Nicola Da; Davenport, James R. A.; Dawson, Kyle S.; Lee, Nathan De; Delubac, Timothée; Deshpande, Rohit; Dhital, Saurav; Dutra-Ferreira, Letícia; Dwelly, Tom; Ealet, Anne; Ebelke, Garrett L.; Edmondson, Edward M.; Eisenstein, Daniel J.; Ellsworth, Tristan; Elsworth, Yvonne; Epstein, Courtney R.; Eracleous, Michael; Escoffier, Stephanie; Esposito, Massimiliano; Evans, Michael L.; Fan, Xiaohui; Fernández-Alvar, Emma; Feuillet, Diane; Ak, Nurten Filiz; Finley, Hayley; Finoguenov, Alexis; Flaherty, Kevin; Fleming, Scott W.; Font-Ribera, Andreu; Foster, Jonathan; Frinchaboy, Peter M.; Galbraith-Frew, J. G.; García, Rafael A.; García-Hernández, D. A.; Pérez, Ana E. García; Gaulme, Patrick; Ge, Jian; Génova-Santos, R.; Georgakakis, A.; Ghezzi, Luan; Gillespie, Bruce A.; Girardi, Léo; Goddard, Daniel; Gontcho, Satya Gontcho A.; Hernández, Jonay I. González; Grebel, Eva K.; Green, Paul J.; Grieb, Jan Niklas; Grieves, Nolan; Gunn, James E.; Guo, Hong; Harding, Paul; Hasselquist, Sten; Hawley, Suzanne L.; Hayden, Michael; Hearty, Fred R.; Hekker, Saskia; Ho, Shirley; Hogg, David W.; Holley-Bockelmann, Kelly; Holtzman, Jon A.; Honscheid, Klaus; Huber, Daniel; Huehnerhoff, Joseph; Ivans, Inese I.; Jiang, Linhua; Johnson, Jennifer A.; Kinemuchi, Karen; Kirkby, David; Kitaura, Francisco; Klaene, Mark A.; Knapp, Gillian R.; Kneib, Jean-Paul; Koenig, Xavier P.; Lam, Charles R.; Lan, Ting-Wen; Lang, Dustin; Laurent, Pierre; Goff, Jean-Marc Le; Leauthaud, Alexie; Lee, Khee-Gan; Lee, Young Sun; Licquia, Timothy C.; Liu, Jian; Long, Daniel C.; López-Corredoira, Martín; Lorenzo-Oliveira, Diego; Lucatello, Sara; Lundgren, Britt; Lupton, Robert H.; III, Claude E. Mack; Mahadevan, Suvrath; Maia, Marcio A. G.; Majewski, Steven R.; Malanushenko, Elena; Malanushenko, Viktor; Manchado, A.; Manera, Marc; Mao, Qingqing; Maraston, Claudia; Marchwinski, Robert C.; Margala, Daniel; Martell, Sarah L.; Martig, Marie; Masters, Karen L.; Mathur, Savita; McBride, Cameron K.; McGehee, Peregrine M.; McGreer, Ian D.; McMahon, Richard G.; Ménard, Brice; Menzel, Marie-Luise; Merloni, Andrea; Mészáros, Szabolcs; Miller, Adam A.; Miralda-Escudé, Jordi; Miyatake, Hironao; Montero-Dorta, Antonio D.; More, Surhud; Morganson, Eric; Morice-Atkinson, Xan; Morrison, Heather L.; Mosser, Benôit; Muna, Demitri; Myers, Adam D.; Nandra, Kirpal; Newman, Jeffrey A.; Neyrinck, Mark; Nguyen, Duy Cuong; Nichol, Robert C.; Nidever, David L.; Noterdaeme, Pasquier; Nuza, Sebastián E.; O’Connell, Julia E.; O’Connell, Robert W.; O’Connell, Ross; Ogando, Ricardo L. C.; Olmstead, Matthew D.; Oravetz, Audrey E.; Oravetz, Daniel J.; Osumi, Keisuke; Owen, Russell; Padgett, Deborah L.; Padmanabhan, Nikhil; Paegert, Martin; Palanque-Delabrouille, Nathalie; Pan, Kaike; Parejko, John K.; Pâris, Isabelle; Park, Changbom; Pattarakijwanich, Petchara; Pellejero-Ibanez, M.; Pepper, Joshua; Percival, Will J.; Pérez-Fournon, Ismael; Pe´rez-Ra`fols, Ignasi; Petitjean, Patrick; Pieri, Matthew M.; Pinsonneault, Marc H.; Mello, Gustavo F. Porto de; Prada, Francisco; Prakash, Abhishek; Price-Whelan, Adrian M.; Protopapas, Pavlos; Raddick, M. Jordan; Rahman, Mubdi; Reid, Beth A.; Rich, James; Rix, Hans-Walter; Robin, Annie C.; Rockosi, Constance M.; Rodrigues, Thaíse S.; Rodríguez-Torres, Sergio; Roe, Natalie A.; Ross, Ashley J.; Ross, Nicholas P.; Rossi, Graziano; Ruan, John J.; Rubiño-Martín, J. A.; Rykoff, Eli S.; Salazar-Albornoz, Salvador; Salvato, Mara; Samushia, Lado; Sánchez, Ariel G.; Santiago, Basílio; Sayres, Conor; Schiavon, Ricardo P.; Schlegel, David J.; Schmidt, Sarah J.; Schneider, Donald P.; Schultheis, Mathias; Schwope, Axel D.; Scóccola, C. G.; Scott, Caroline; Sellgren, Kris; Seo, Hee-Jong; Serenelli, Aldo; Shane, Neville; Shen, Yue; Shetrone, Matthew; Shu, Yiping; Aguirre, V. Silva; Sivarani, Thirupathi; Skrutskie, M. F.; Slosar, Anže; Smith, Verne V.; Sobreira, Flávia; Souto, Diogo; Stassun, Keivan G.; Steinmetz, Matthias; Stello, Dennis; Strauss, Michael A.; Streblyanska, Alina; Suzuki, Nao; Swanson, Molly E. C.; Tan, Jonathan C.; Tayar, Jamie; Terrien, Ryan C.; Thakar, Aniruddha R.; Thomas, Daniel; Thomas, Neil; Thompson, Benjamin A.; Tinker, Jeremy L.; Tojeiro, Rita; Troup, Nicholas W.; Vargas-Magaña, Mariana; Vazquez, Jose A.; Verde, Licia; Viel, Matteo; Vogt, Nicole P.; Wake, David A.; Wang, Ji; Weaver, Benjamin A.; Weinberg, David H.; Weiner, Benjamin J.; White, Martin; Wilson, John C.; Wisniewski, John P.; Wood-Vasey, W. M.; Ye`che, Christophe; York, Donald G.; Zakamska, Nadia L.; Zamora, O.; Zasowski, Gail; Zehavi, Idit; Zhao, Gong-Bo; Zheng, Zheng; Zhou (周旭), Xu; Zhou (周志民), Zhimin; Zou (邹虎), Hu; Zhu, Guangtun

2015-07-20

The third generation of the Sloan Digital Sky Survey (SDSS-III) took data from 2008 to 2014 using the original SDSS wide-field imager, the original and an upgraded multi-object fiber-fed optical spectrograph, a new near-infrared high-resolution spectrograph, and a novel optical interferometer. All of the data from SDSS-III are now made public. In particular, this paper describes Data Release 11 (DR11) including all data acquired through 2013 July, and Data Release 12 (DR12) adding data acquired through 2014 July (including all data included in previous data releases), marking the end of SDSS-III observing. Relative to our previous public release (DR10), DR12 adds one million new spectra of galaxies and quasars from the Baryon Oscillation Spectroscopic Survey (BOSS) over an additional 3000 deg² of sky, more than triples the number of H-band spectra of stars as part of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE), and includes repeated accurate radial velocity measurements of 5500 stars from the Multi-object APO Radial Velocity Exoplanet Large-area Survey (MARVELS). The APOGEE outputs now include the measured abundances of 15 different elements for each star. In total, SDSS-III added 5200 deg² of ugriz imaging; 155,520 spectra of 138,099 stars as part of the Sloan Exploration of Galactic Understanding and Evolution 2 (SEGUE-2) survey; 2,497,484 BOSS spectra of 1,372,737 galaxies, 294,512 quasars, and 247,216 stars over 9376 deg²; 618,080 APOGEE spectra of 156,593 stars; and 197,040 MARVELS spectra of 5513 stars. Since its first light in 1998, SDSS has imaged over 1/3 of the Celestial sphere in five bands and obtained over five million astronomical spectra.

M DWARF FLARES FROM TIME-RESOLVED SLOAN DIGITAL SKY SURVEY SPECTRA

International Nuclear Information System (INIS)

Hilton, Eric J.; Hawley, Suzanne L.; Kowalski, Adam F.; West, Andrew A.

2010-01-01

We have identified 63 flares on M dwarfs from the individual component spectra in the Sloan Digital Sky Survey (SDSS) using a novel measurement of emission-line strength called the Flare Line Index. Each of the ∼38,000 M dwarfs in the SDSS low-mass star spectroscopic sample of West et al. was observed several times (usually 3-5) in exposures that were typically 9-25 minutes in duration. Our criteria allowed us to identify flares that exhibit very strong Hα and Hβ emission-line strength and/or significant variability in those lines throughout the course of the exposures. The flares we identified have characteristics consistent with flares observed by classical spectroscopic monitoring. The flare duty cycle for the objects in our sample is found to increase from 0.02% for early M dwarfs to 3% for late M dwarfs. We find that the flare duty cycle is larger in the population near the Galactic plane and that the flare stars are more spatially restricted than the magnetically active but non-flaring stars. This suggests that flare frequency may be related to stellar age (younger stars are more likely to flare) and that the flare stars are younger than the mean active population.

INTERNAL EXTINCTION IN THE SLOAN DIGITAL SKY SURVEY LATE-TYPE GALAXIES

International Nuclear Information System (INIS)

Cho, Jungyeon; Park, Changbom

2009-01-01

We study internal extinction of late-type galaxies in the Sloan Digital Sky Survey. We find that the degree of internal extinction depends on both the concentration index c and K s -band absolute magnitude M K . We give simple fitting functions for internal extinction. In particular, we present analytic formulae giving the extinction-corrected magnitudes from the observed optical parameters. For example, the extinction-corrected r-band absolute magnitude can be obtained by M r,0 =-20.77 +(-1+√(1+4Δ(M r,obs +20.77+4.93Δ)))/2Δ, where Δ = 0.236{1.35(c - 2.48) 2 - 1.14} log(a/b), c = R 90 /R 50 is the the concentration index, and a/b is the isophotal axis ratio of the 25 mag arcsec -2 isophote in the i band. The 1σ error in M r,0 is 0.21 log(a/b). Late-type galaxies with very different inclinations are found to trace almost the same sequence in the (u - r)-M r diagram when our prescriptions for extinction correction are applied. We also find that (u - r) color can be a third independent parameter that determines the degree of internal extinction.

Proinflammatory Factors Mediate Paclitaxel-Induced Impairment of Learning and Memory

Directory of Open Access Journals (Sweden)

Zhao Li

2018-01-01

Full Text Available The chemotherapeutic agent paclitaxel is widely used for cancer treatment. Paclitaxel treatment impairs learning and memory function, a side effect that reduces the quality of life of cancer survivors. However, the neural mechanisms underlying paclitaxel-induced impairment of learning and memory remain unclear. Paclitaxel treatment leads to proinflammatory factor release and neuronal apoptosis. Thus, we hypothesized that paclitaxel impairs learning and memory function through proinflammatory factor-induced neuronal apoptosis. Neuronal apoptosis was assessed by TUNEL assay in the hippocampus. Protein expression levels of tumor necrosis factor-α (TNF-α and interleukin-1β (IL-1β in the hippocampus tissue were analyzed by Western blot assay. Spatial learning and memory function were determined by using the Morris water maze (MWM test. Paclitaxel treatment significantly increased the escape latencies and decreased the number of crossing in the MWM test. Furthermore, paclitaxel significantly increased the number of TUNEL-positive neurons in the hippocampus. Also, paclitaxel treatment increased the expression levels of TNF-α and IL-1β in the hippocampus tissue. In addition, the TNF-α synthesis inhibitor thalidomide significantly attenuated the number of paclitaxel-induced TUNEL-positive neurons in the hippocampus and restored the impaired spatial learning and memory function in paclitaxel-treated rats. These data suggest that TNF-α is critically involved in the paclitaxel-induced impairment of learning and memory function.

The roots of modern oncology: from discovery of new antitumor anthracyclines to their clinical use.

Science.gov (United States)

Cassinelli, Giuseppe

2016-06-02

In May 1960, the Farmitalia CEO Dr. Bertini and the director of the Istituto Nazionale dei Tumori of Milan Prof. Bucalossi (talent scout and city's Mayor) signed a research agreement for the discovery and development up to clinical trials of new natural antitumor agents. This agreement can be considered as a pioneering and fruitful example of a translational discovery program with relevant transatlantic connections. Owing to an eclectic Streptomyces, found near Castel del Monte (Apulia), and to the skilled and motivated participants of both institutions, a new natural antitumor drug, daunomycin, was ready for clinical trials within 3 years. Patent interference by the Farmitalia French partner was overcome by the good quality of the Italian drug and by the cooperation between Prof. Di Marco, director of the Istituto Ricerche Farmitalia Research Laboratories for Microbiology and Chemotherapy, and Prof. Karnofsky, head of the Sloan-Kettering Cancer Institute of New York, leading to the first transatlantic clinical trials. The search for daunomycin's sister anthracyclines led to the discovery and development of adriamycin, one of the best drugs born in Milan. This was the second act prologue of the history of Italian antitumor discovery and clinical oncology, which started in July 1969 when Prof. Di Marco sent Prof. Bonadonna the first vials of adriamycin (doxorubicin) to be tested in clinical trials. This article reviews the Milan scene in the 1960s, a city admired and noted for the outstanding scientific achievements of its private and public institutions in drugs and industrial product discovery.

Radiation Induced Vaccination to Breast Cancer

Science.gov (United States)

2016-12-01

of anti-TGFβ antibody clearly boosted the CD8 memory pool, especially the central memory type, to the detriment of T effector cells. Similar findings...interest also because T cell inflammation of the memory type correlates with better prognosis in colorectal cancer presumably through stronger recall ...ABSTRACT Inhibiting TGFβ in the context of focal irradiation seems to create a favorable systemic immune landscape that drives T cell memory

Children's Memories for Painful Cancer Treatment Procedures: Implications for Distress.

Science.gov (United States)

Chen, Edith; Zeltzer, Lonnie K.; Craske, Michelle G.; Katz, Ernest R.

2000-01-01

Examined memory of 3- to 18-year-olds with leukemia regarding lumbar punctures (LP). Found that children displayed considerable accuracy for event details, with accuracy increasing with age. Use of Versed (anxiolytic medication described as a "memory blocker") was not related to recall. Higher distress predicted greater exaggerations in…

SPATIAL ANISOTROPY OF GALAXY KINEMATICS IN SLOAN DIGITAL SKY SURVEY GALAXY CLUSTERS

International Nuclear Information System (INIS)

Skielboe, Andreas; Wojtak, Radosław; Pedersen, Kristian; Rozo, Eduardo; Rykoff, Eli S.

2012-01-01

Measurements of galaxy cluster kinematics are important in understanding the dynamical state and evolution of clusters of galaxies, as well as constraining cosmological models. While it is well established that clusters exhibit non-spherical geometries, evident in the distribution of galaxies on the sky, azimuthal variations of galaxy kinematics within clusters have yet to be observed. Here we measure the azimuthal dependence of the line-of-sight velocity dispersion profile in a stacked sample of 1743 galaxy clusters from the Sloan Digital Sky Survey (SDSS). The clusters are drawn from the SDSS DR8 redMaPPer catalog. We find that the line-of-sight velocity dispersion of galaxies lying along the major axis of the central galaxy is larger than those that lie along the minor axis. This is the first observational detection of anisotropic kinematics of galaxies in clusters. We show that the result is consistent with predictions from numerical simulations. Furthermore, we find that the degree of projected anisotropy is strongly dependent on the line-of-sight orientation of the galaxy cluster, opening new possibilities for assessing systematics in optical cluster finding.

The Missing Link: Early Methane ("T") Dwarfs in the Sloan Digital Sky Survey.

Science.gov (United States)

Leggett; Geballe; Fan; Schneider; Gunn; Lupton; Knapp; Strauss; McDaniel; Golimowski; Henry; Peng; Tsvetanov; Uomoto; Zheng; Hill; Ramsey; Anderson; Annis; Bahcall; Brinkmann; Chen; Csabai; Fukugita; Hennessy; Hindsley; Ivezic; Lamb; Munn; Pier; Schlegel; Smith; Stoughton; Thakar; York

2000-06-10

We report the discovery of three cool brown dwarfs that fall in the effective temperature gap between the latest L dwarfs currently known, with no methane absorption bands in the 1-2.5 µm range, and the previously known methane (T) dwarfs, whose spectra are dominated by methane and water. The newly discovered objects were detected as very red objects in the Sloan Digital Sky Survey imaging data and have JHK colors between the red L dwarfs and the blue Gl 229B-like T dwarfs. They show both CO and CH(4) absorption in their near-infrared spectra in addition to H(2)O, with weaker CH(4) absorption features in the H and K bands than those in all other methane dwarfs reported to date. Due to the presence of CH(4) in these bands, we propose that these objects are early T dwarfs. The three form part of the brown dwarf spectral sequence and fill in the large gap in the overall spectral sequence from the hottest main-sequence stars to the coolest methane dwarfs currently known.

Sloan Digital Sky Survey photometric telescope automation and observing software

International Nuclear Information System (INIS)

Eric H. Neilsen, Jr.; email = neilsen@fnal.gov

2002-01-01

The photometric telescope (PT) provides observations necessary for the photometric calibration of the Sloan Digital Sky Survey (SDSS). Because the attention of the observing staff is occupied by the operation of the 2.5 meter telescope which takes the survey data proper, the PT must reliably take data with little supervision. In this paper we describe the PT's observing program, MOP, which automates most tasks necessary for observing. MOP's automated target selection is closely modeled on the actions a human observer might take, and is built upon a user interface that can be (and has been) used for manual operation. This results in an interface that makes it easy for an observer to track the activities of the automating procedures and intervene with minimum disturbance when necessary. MOP selects targets from the same list of standard star and calibration fields presented to the user, and chooses standard star fields covering ranges of airmass, color, and time necessary to monitor atmospheric extinction and produce a photometric solution. The software determines when additional standard star fields are unnecessary, and selects survey calibration fields according to availability and priority. Other automated features of MOP, such as maintaining the focus and keeping a night log, are also built around still functional manual interfaces, allowing the observer to be as active in observing as desired; MOP's automated features may be used as tools for manual observing, ignored entirely, or allowed to run the telescope with minimal supervision when taking routine data

The Ninth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the SDSS-III Baryon Oscillation Spectroscopic Survey

Energy Technology Data Exchange (ETDEWEB)

Ahn, Christopher P.; Alexandroff, Rachael; Allende Prieto, Carlos; Anderson, Scott F.; Anderton, Timothy; Andrews, Brett H.; Aubourg, Éric; Bailey, Stephen; Balbinot, Eduardo; Barnes, Rory; Bautista, Julian; Beers, Timothy C.; Beifiori, Alessandra; Berlind, Andreas A.; Bhardwaj, Vaishali; Bizyaev, Dmitry; Blake, Cullen H.; Blanton, Michael R.; Blomqvist, Michael; Bochanski, John J.; Bolton, Adam S.; Borde, Arnaud; Bovy, Jo; Brandt, W. N.; Brinkmann, J.; Brown, Peter J.; Brownstein, Joel R.; Bundy, Kevin; Busca, N. G.; Carithers, William; Carnero, Aurelio R.; Carr, Michael A.; Casetti-Dinescu, Dana I.; Chen, Yanmei; Chiappini, Cristina; Comparat, Johan; Connolly, Natalia; Crepp, Justin R.; Cristiani, Stefano; Croft, Rupert A. C.; Cuesta, Antonio J.; da Costa, Luiz N.; Davenport, James R. A.; Dawson, Kyle S.; de Putter, Roland; De Lee, Nathan; Delubac, Timothée; Dhital, Saurav; Ealet, Anne; Ebelke, Garrett L.; Edmondson, Edward M.; Eisenstein, Daniel J.; Escoffier, S.; Esposito, Massimiliano; Evans, Michael L.; Fan, Xiaohui; Femenía Castellá, Bruno; Fernández Alvar, Emma; Ferreira, Leticia D.; Filiz Ak, N.; Finley, Hayley; Fleming, Scott W.; Font-Ribera, Andreu; Frinchaboy, Peter M.; García-Hernández, D. A.; Pérez, A. E. García; Ge, Jian; Génova-Santos, R.; Gillespie, Bruce A.; Girardi, Léo; González Hernández, Jonay I.; Grebel, Eva K.; Gunn, James E.; Guo, Hong; Haggard, Daryl; Hamilton, Jean-Christophe; Harris, David W.; Hawley, Suzanne L.; Hearty, Frederick R.; Ho, Shirley; Hogg, David W.; Holtzman, Jon A.; Honscheid, Klaus; Huehnerhoff, J.; Ivans, Inese I.; Ivezić, Željko; Jacobson, Heather R.; Jiang, Linhua; Johansson, Jonas; Johnson, Jennifer A.; Kauffmann, Guinevere; Kirkby, David; Kirkpatrick, Jessica A.; Klaene, Mark A.; Knapp, Gillian R.; Kneib, Jean-Paul; Le Goff, Jean-Marc; Leauthaud, Alexie; Lee, Khee-Gan; Lee, Young Sun; Long, Daniel C.; Loomis, Craig P.; Lucatello, Sara; Lundgren, Britt; Lupton, Robert H.; Ma, Bo; Ma, Zhibo; MacDonald, Nicholas; Mack, Claude E.; Mahadevan, Suvrath; Maia, Marcio A. G.; Majewski, Steven R.; Makler, Martin; Malanushenko, Elena; Malanushenko, Viktor; Manchado, A.; Mandelbaum, Rachel; Manera, Marc; Maraston, Claudia; Margala, Daniel; Martell, Sarah L.; McBride, Cameron K.; McGreer, Ian D.; McMahon, Richard G.; Ménard, Brice; Meszaros, Sz.; Miralda-Escudé, Jordi; Montero-Dorta, Antonio D.; Montesano, Francesco; Morrison, Heather L.; Muna, Demitri; Munn, Jeffrey A.; Murayama, Hitoshi; Myers, Adam D.; Neto, A. F.; Nguyen, Duy Cuong; Nichol, Robert C.; Nidever, David L.; Noterdaeme, Pasquier; Nuza, Sebastián E.; Ogando, Ricardo L. C.; Olmstead, Matthew D.; Oravetz, Daniel J.; Owen, Russell; Padmanabhan, Nikhil; Palanque-Delabrouille, Nathalie; Pan, Kaike; Parejko, John K.; Parihar, Prachi; Pâris, Isabelle; Pattarakijwanich, Petchara; Pepper, Joshua; Percival, Will J.; Pérez-Fournon, Ismael; Pérez-Ràfols, Ignasi; Petitjean, Patrick; Pforr, Janine; Pieri, Matthew M.; Pinsonneault, Marc H.; Porto de Mello, G. F.; Prada, Francisco; Price-Whelan, Adrian M.; Raddick, M. Jordan; Rebolo, Rafael; Rich, James; Richards, Gordon T.; Robin, Annie C.; Rocha-Pinto, Helio J.; Rockosi, Constance M.; Roe, Natalie A.; Ross, Ashley J.; Ross, Nicholas P.; Rossi, Graziano; Rubiño-Martin, J. A.; Samushia, Lado; Sanchez Almeida, J.; Sánchez, Ariel G.; Santiago, Basílio; Sayres, Conor; Schlegel, David J.; Schlesinger, Katharine J.; Schmidt, Sarah J.; Schneider, Donald P.; Schultheis, Mathias; Schwope, Axel D.; Scóccola, C. G.; Seljak, Uros; Sheldon, Erin; Shen, Yue; Shu, Yiping; Simmerer, Jennifer; Simmons, Audrey E.; Skibba, Ramin A.; Skrutskie, M. F.; Slosar, A.; Sobreira, Flavia; Sobeck, Jennifer S.; Stassun, Keivan G.; Steele, Oliver; Steinmetz, Matthias; Strauss, Michael A.; Streblyanska, Alina; Suzuki, Nao; Swanson, Molly E. C.; Tal, Tomer; Thakar, Aniruddha R.; Thomas, Daniel; Thompson, Benjamin A.; Tinker, Jeremy L.; Tojeiro, Rita; Tremonti, Christy A.; Vargas Magaña, M.; Verde, Licia; Viel, Matteo; Vikas, Shailendra K.; Vogt, Nicole P.; Wake, David A.; Wang, Ji; Weaver, Benjamin A.; Weinberg, David H.; Weiner, Benjamin J.; West, Andrew A.; White, Martin; Wilson, John C.; Wisniewski, John P.; Wood-Vasey, W. M.; Yanny, Brian; Yèche, Christophe; York, Donald G.; Zamora, O.; Zasowski, Gail; Zehavi, Idit; Zhao, Gong-Bo; Zheng, Zheng; Zhu, Guangtun; Zinn, Joel C.

2012-11-19

The Sloan Digital Sky Survey III (SDSS-III) presents the first spectroscopic data from the Baryon Oscillation Spectroscopic Survey (BOSS). This ninth data release (DR9) of the SDSS project includes 535,995 new galaxy spectra (median z=0.52), 102,100 new quasar spectra (median z=2.32), and 90,897 new stellar spectra, along with the data presented in previous data releases. These spectra were obtained with the new BOSS spectrograph and were taken between 2009 December and 2011 July. In addition, the stellar parameters pipeline, which determines radial velocities, surface temperatures, surface gravities, and metallicities of stars, has been updated and refined with improvements in temperature estimates for stars with T_eff<5000 K and in metallicity estimates for stars with [Fe/H]>-0.5. DR9 includes new stellar parameters for all stars presented in DR8, including stars from SDSS-I and II, as well as those observed as part of the SDSS-III Sloan Extension for Galactic Understanding and Exploration-2 (SEGUE-2). The astrometry error introduced in the DR8 imaging catalogs has been corrected in the DR9 data products. The next data release for SDSS-III will be in Summer 2013, which will present the first data from the Apache Point Observatory Galactic Evolution Experiment (APOGEE) along with another year of data from BOSS, followed by the final SDSS-III data release in December 2014.

THE MULTI-OBJECT, FIBER-FED SPECTROGRAPHS FOR THE SLOAN DIGITAL SKY SURVEY AND THE BARYON OSCILLATION SPECTROSCOPIC SURVEY

International Nuclear Information System (INIS)

Smee, Stephen A.; Barkhouser, Robert H.; Gunn, James E.; Carr, Michael A.; Lupton, Robert H.; Loomis, Craig; Uomoto, Alan; Roe, Natalie; Schlegel, David; Rockosi, Constance M.; Leger, French; Owen, Russell; Anderson, Lauren; Dawson, Kyle S.; Olmstead, Matthew D.; Brinkmann, Jon; Long, Dan; Honscheid, Klaus; Harding, Paul; Annis, James

2013-01-01

We present the design and performance of the multi-object fiber spectrographs for the Sloan Digital Sky Survey (SDSS) and their upgrade for the Baryon Oscillation Spectroscopic Survey (BOSS). Originally commissioned in Fall 1999 on the 2.5 m aperture Sloan Telescope at Apache Point Observatory, the spectrographs produced more than 1.5 million spectra for the SDSS and SDSS-II surveys, enabling a wide variety of Galactic and extra-galactic science including the first observation of baryon acoustic oscillations in 2005. The spectrographs were upgraded in 2009 and are currently in use for BOSS, the flagship survey of the third-generation SDSS-III project. BOSS will measure redshifts of 1.35 million massive galaxies to redshift 0.7 and Lyα absorption of 160,000 high redshift quasars over 10,000 deg 2 of sky, making percent level measurements of the absolute cosmic distance scale of the universe and placing tight constraints on the equation of state of dark energy. The twin multi-object fiber spectrographs utilize a simple optical layout with reflective collimators, gratings, all-refractive cameras, and state-of-the-art CCD detectors to produce hundreds of spectra simultaneously in two channels over a bandpass covering the near-ultraviolet to the near-infrared, with a resolving power R = λ/FWHM ∼ 2000. Building on proven heritage, the spectrographs were upgraded for BOSS with volume-phase holographic gratings and modern CCD detectors, improving the peak throughput by nearly a factor of two, extending the bandpass to cover 360 nm < λ < 1000 nm, and increasing the number of fibers from 640 to 1000 per exposure. In this paper we describe the original SDSS spectrograph design and the upgrades implemented for BOSS, and document the predicted and measured performances

THE MULTI-OBJECT, FIBER-FED SPECTROGRAPHS FOR THE SLOAN DIGITAL SKY SURVEY AND THE BARYON OSCILLATION SPECTROSCOPIC SURVEY

Energy Technology Data Exchange (ETDEWEB)

Smee, Stephen A.; Barkhouser, Robert H. [Department of Physics and Astronomy, Johns Hopkins University, Baltimore, MD 21218 (United States); Gunn, James E.; Carr, Michael A.; Lupton, Robert H.; Loomis, Craig [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Uomoto, Alan [Observatories of the Carnegie Institution of Washington, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); Roe, Natalie; Schlegel, David [Physics Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States); Rockosi, Constance M. [UC Observatories and Department of Astronomy and Astrophysics, University of California, Santa Cruz, 375 Interdisciplinary Sciences Building (ISB) Santa Cruz, CA 95064 (United States); Leger, French; Owen, Russell; Anderson, Lauren [Department of Astronomy, University of Washington, Box 351580, Seattle, WA 09195 (United States); Dawson, Kyle S.; Olmstead, Matthew D. [Department of Physics and Astronomy, University of Utah, Salt Lake City, UT 84112 (United States); Brinkmann, Jon; Long, Dan [Apache Point Observatory, Sunspot, NM 88349 (United States); Honscheid, Klaus [Department of Physics and Center for Cosmology and Astro-Particle Physics, Ohio State University, Columbus, OH 43210 (United States); Harding, Paul [Department of Astronomy, Case Western Reserve University, Cleveland, OH 44106 (United States); Annis, James, E-mail: smee@pha.jhu.edu [Fermi National Accelerator Laboratory, P.O. Box 500, Batavia, IL 60510 (United States); and others

2013-08-01

We present the design and performance of the multi-object fiber spectrographs for the Sloan Digital Sky Survey (SDSS) and their upgrade for the Baryon Oscillation Spectroscopic Survey (BOSS). Originally commissioned in Fall 1999 on the 2.5 m aperture Sloan Telescope at Apache Point Observatory, the spectrographs produced more than 1.5 million spectra for the SDSS and SDSS-II surveys, enabling a wide variety of Galactic and extra-galactic science including the first observation of baryon acoustic oscillations in 2005. The spectrographs were upgraded in 2009 and are currently in use for BOSS, the flagship survey of the third-generation SDSS-III project. BOSS will measure redshifts of 1.35 million massive galaxies to redshift 0.7 and Ly{alpha} absorption of 160,000 high redshift quasars over 10,000 deg{sup 2} of sky, making percent level measurements of the absolute cosmic distance scale of the universe and placing tight constraints on the equation of state of dark energy. The twin multi-object fiber spectrographs utilize a simple optical layout with reflective collimators, gratings, all-refractive cameras, and state-of-the-art CCD detectors to produce hundreds of spectra simultaneously in two channels over a bandpass covering the near-ultraviolet to the near-infrared, with a resolving power R = {lambda}/FWHM {approx} 2000. Building on proven heritage, the spectrographs were upgraded for BOSS with volume-phase holographic gratings and modern CCD detectors, improving the peak throughput by nearly a factor of two, extending the bandpass to cover 360 nm < {lambda} < 1000 nm, and increasing the number of fibers from 640 to 1000 per exposure. In this paper we describe the original SDSS spectrograph design and the upgrades implemented for BOSS, and document the predicted and measured performances.

THE MULTI-OBJECT, FIBER-FED SPECTROGRAPHS FOR THE SLOAN DIGITAL SKY SURVEY AND THE BARYON OSCILLATION SPECTROSCOPIC SURVEY

Energy Technology Data Exchange (ETDEWEB)

Smee, Stephen A.; Gunn, James E.; Uomoto, Alan; Roe, Natalie; Schlegel, David; Rockosi, Constance M.; Carr, Michael A.; Leger, French; Dawson, Kyle S.; Olmstead, Matthew D.; Brinkmann, Jon; Owen, Russell; Barkhouser, Robert H.; Honscheid, Klaus; Harding, Paul; Long, Dan; Lupton, Robert H.; Loomis, Craig; Anderson, Lauren; Annis, James; Bernardi, Mariangela; Bhardwaj, Vaishali; Bizyaev, Dmitry; Bolton, Adam S.; Brewington, Howard; Briggs, John W.; Burles, Scott; Burns, James G.; Castander, Francisco Javier; Connolly, Andrew; Davenport, James R. A.; Ebelke, Garrett; Epps, Harland; Feldman, Paul D.; Friedman, Scott D.; Frieman, Joshua; Heckman, Timothy; Hull, Charles L.; Knapp, Gillian R.; Lawrence, David M.; Loveday, Jon; Mannery, Edward J.; Malanushenko, Elena; Malanushenko, Viktor; Merrelli, Aronne James; Muna, Demitri; Newman, Peter R.; Nichol, Robert C.; Oravetz, Daniel; Pan, Kaike; Pope, Adrian C.; Ricketts, Paul G.; Shelden, Alaina; Sandford, Dale; Siegmund, Walter; Simmons, Audrey; Smith, D. Shane; Snedden, Stephanie; Schneider, Donald P.; SubbaRao, Mark; Tremonti, Christy; Waddell, Patrick; York, Donald G.

2013-07-12

We present the design and performance of the multi-object fiber spectrographs for the Sloan Digital Sky Survey (SDSS) and their upgrade for the Baryon Oscillation Spectroscopic Survey (BOSS). Originally commissioned in Fall 1999 on the 2.5-m aperture Sloan Telescope at Apache Point Observatory, the spectrographs produced more than 1.5 million spectra for the SDSS and SDSS-II surveys, enabling a wide variety of Galactic and extra-galactic science including the first observation of baryon acoustic oscillations in 2005. The spectrographs were upgraded in 2009 and are currently in use for BOSS, the flagship survey of the third-generation SDSS-III project. BOSS will measure redshifts of 1.35 million massive galaxies to redshift 0.7 and Lyman-alpha absorption of 160,000 high redshift quasars over 10,000 square degrees of sky, making percent level measurements of the absolute cosmic distance scale of the Universe and placing tight constraints on the equation of state of dark energy. The twin multi-object fiber spectrographs utilize a simple optical layout with reflective collimators, gratings, all-refractive cameras, and state-of-the-art CCD detectors to produce hundreds of spectra simultaneously in two channels over a bandpass covering the near ultraviolet to the near infrared, with a resolving power R = \\lambda/FWHM ~ 2000. Building on proven heritage, the spectrographs were upgraded for BOSS with volume-phase holographic gratings and modern CCD detectors, improving the peak throughput by nearly a factor of two, extending the bandpass to cover 360 < \\lambda < 1000 nm, and increasing the number of fibers from 640 to 1000 per exposure. In this paper we describe the original SDSS spectrograph design and the upgrades implemented for BOSS, and document the predicted and measured performances.

The chemotherapeutic agent paclitaxel selectively impairs reversal learning while sparing prior learning, new learning and episodic memory.

Science.gov (United States)

Panoz-Brown, Danielle; Carey, Lawrence M; Smith, Alexandra E; Gentry, Meredith; Sluka, Christina M; Corbin, Hannah E; Wu, Jie-En; Hohmann, Andrea G; Crystal, Jonathon D

2017-10-01

Chemotherapy is widely used to treat patients with systemic cancer. The efficacy of cancer therapies is frequently undermined by adverse side effects that have a negative impact on the quality of life of cancer survivors. Cancer patients who receive chemotherapy often experience chemotherapy-induced cognitive impairment across a variety of domains including memory, learning, and attention. In the current study, the impact of paclitaxel, a taxane derived chemotherapeutic agent, on episodic memory, prior learning, new learning, and reversal learning were evaluated in rats. Neurogenesis was quantified post-treatment in the dentate gyrus of the same rats using immunostaining for 5-Bromo-2'-deoxyuridine (BrdU) and Ki67. Paclitaxel treatment selectively impaired reversal learning while sparing episodic memory, prior learning, and new learning. Furthermore, paclitaxel-treated rats showed decreases in markers of hippocampal cell proliferation, as measured by markers of cell proliferation assessed using immunostaining for Ki67 and BrdU. This work highlights the importance of using multiple measures of learning and memory to identify the pattern of impaired and spared aspects of chemotherapy-induced cognitive impairment. Copyright © 2017 Elsevier Inc. All rights reserved.

Current applications of PET imaging of sex hormone receptors with a fluorinated analogue of estradiol or of testosterone

International Nuclear Information System (INIS)

Talbot, J-N.; Montravers, F.; Huchet, V.; Michaud, L.; Ohnona, J.; Balogova, S.; Kerrou, K.; Gligorov, V.; Lotz, P.; Nataf, V.; Cussenot, O.; Darai, E.

2015-01-01

utility in those settings; only initial results are available. The indication of PET and PET/CT has been even more disputed in prostate carcinoma, due to the lack of significant FDG uptake in most cases, at least before the castration-resistant stage. Using FDHT, a fluorinated testosterone analogue, PET is able to detect the over-expression of the androgen receptor (AR) in lesions, at a whole-body level. At least partly due to the rather large number of alternative tracers that are in development or even routinely available in some countries, few FDHT studies have been published until now. From absorbed dose values previously published for FES by the team of University of Washington School of Medicine at Seattle, and for FDHT by the teams of Memorial Sloan-Kettering Cancer Center at New York and of Washington University at St. Louis, we applied the coefficients of ICRP publication 103 and calculated an effective dose per unit of injected activity of 0.023 mSv/MBq for FES and 0.018 mSv/MBq for FDHT. The radiation exposure is of the same order of magnitude as with FDG.

COSMOLOGICAL CONSTRAINTS FROM THE SLOAN DIGITAL SKY SURVEY MaxBCG CLUSTER CATALOG

International Nuclear Information System (INIS)

Rozo, Eduardo; Weinberg, David H.; Wechsler, Risa H.; Rykoff, Eli S.; Annis, James T.; Frieman, Joshua A.; Becker, Matthew R.; Evrard, August E.; Hao Jiangang; McKay, Timothy A.; Hansen, Sarah M.; Johnston, David E.; Koester, Benjamin P.; Sheldon, Erin S.

2010-01-01

We use the abundance and weak-lensing mass measurements of the Sloan Digital Sky Survey maxBCG cluster catalog to simultaneously constrain cosmology and the richness-mass relation of the clusters. Assuming a flat ΛCDM cosmology, we find σ 8 (Ω m /0.25) 0.41 = 0.832 ± 0.033 after marginalization over all systematics. In common with previous studies, our error budget is dominated by systematic uncertainties, the primary two being the absolute mass scale of the weak-lensing masses of the maxBCG clusters, and uncertainty in the scatter of the richness-mass relation. Our constraints are fully consistent with the WMAP five-year data, and in a joint analysis we find σ 8 = 0.807 ± 0.020 and Ω m = 0.265 ± 0.016, an improvement of nearly a factor of 2 relative to WMAP5 alone. Our results are also in excellent agreement with and comparable in precision to the latest cosmological constraints from X-ray cluster abundances. The remarkable consistency among these results demonstrates that cluster abundance constraints are not only tight but also robust, and highlight the power of optically selected cluster samples to produce precision constraints on cosmological parameters.

CATACLYSMIC VARIABLES FROM THE SLOAN DIGITAL SKY SURVEY. VIII. THE FINAL YEAR (2007–2008)

International Nuclear Information System (INIS)

Szkody, Paula; Anderson, Scott F.; Brooks, Keira; Kronberg, Martin; Riecken, Thomas; Gänsicke, Boris T.; Ross, Nicholas P.; Schmidt, Gary D.; Schneider, Donald P.; Agüeros, Marcel A.; Gomez-Moran, Ada N.; Schwope, Axel D.; Knapp, Gillian R.; Schreiber, Matthias R.

2011-01-01

This paper completes the series of cataclysmic variables (CVs) identified from the Sloan Digital Sky Survey (SDSS) I/II. The coordinates, magnitudes, and spectra of 33 CVs are presented. Among the 33 are eight systems known prior to SDSS (CT Ser, DO Leo, HK Leo, IR Com, V849 Her, V405 Peg, PG1230+226, and HS0943+1404), as well as nine objects recently found through various photometric surveys. Among the systems identified since the SDSS are two polar candidates, two intermediate polar candidates, and one candidate for containing a pulsating white dwarf. Our follow-up data have confirmed a polar candidate from Paper VII and determined tentative periods for three of the newly identified CVs. A complete summary table of the 285 CVs with spectra from SDSS I/II is presented as well as a link to an online table of all known CVs from both photometry and spectroscopy that will continue to be updated as future data appear.

A NEAR-INFRARED SPECTROSCOPIC SURVEY OF COOL WHITE DWARFS IN THE SLOAN DIGITAL SKY SURVEY

International Nuclear Information System (INIS)

Kilic, Mukremin; Kowalski, Piotr M.; Von Hippel, Ted

2009-01-01

We present near-infrared photometric observations of 15 and spectroscopic observations of 38 cool white dwarfs (WDs). This is the largest near-infrared spectroscopic survey of cool WDs to date. Combining the Sloan Digital Sky Survey photometry and our near-infrared data, we perform a detailed model atmosphere analysis. The spectral energy distributions of our objects are explained fairly well by model atmospheres with temperatures ranging from 6300 K down to 4200 K. Two WDs show significant absorption in the infrared, and are best explained with mixed H/He atmosphere models. Based on the up-to-date model atmosphere calculations by Kowalski and Saumon, we find that the majority of the stars in our sample have hydrogen-rich atmospheres. We do not find any pure helium atmosphere WDs below 5000 K, and we find a trend of increasing hydrogen to helium ratio with decreasing temperature. These findings present an important challenge to understanding the spectral evolution of WDs.

Medical applications of accelerators at Tata Memorial Centre

International Nuclear Information System (INIS)

Dinshaw, K.A.

2003-01-01

The Tata Memorial Centre constitutes the national comprehensive cancer centre for the prevention, diagnosis, treatment and research on cancer. It is well equipped with sophisticated state-of-the-art equipment capable of delivering External Beam Radiotherapy (Ebert) and Brachytherapy. Nearly 400 patients receive Ebert daily at the institute from a team of highly skilled and dedicated radiation oncologists, medical physicists and technologists, making it one of the busiest centres in the country

Two-dimensional Topology of the Sloan Digital Sky Survey

Science.gov (United States)

Hoyle, Fiona; Vogeley, Michael S.; Gott, J. Richard, III; Blanton, Michael; Tegmark, Max; Weinberg, David H.; Bahcall, N.; Brinkmann, J.; York, D.

2002-12-01

We present the topology of a volume-limited sample of 11,884 galaxies, selected from an apparent magnitude limited sample of over 100,000 galaxies observed as part of the Sloan Digital Sky Survey (SDSS). The data currently cover three main regions on the sky: one in the Galactic north and one in the south, both at zero degrees declination, and one area in the north at higher declination. Each of these areas covers a wide range of survey longitude but a narrow range of survey latitude, allowing the two-dimensional genus to be measured. The genus curves of the SDSS subsamples are similar, after appropriately normalizing these measurements for the different areas. We sum the genus curves from the three areas to obtain the total genus curve of the SDSS. The total curve has a shape similar to the genus curve derived from mock catalogs drawn from the Hubble volume ΛCDM simulation and is similar to that of a Gaussian random field. Likewise, comparison with the genus of the Two-Degree Field Galaxy Redshift Survey, after normalization for the difference in area, reveals remarkable similarity in the topology of these samples. We test for the effects of galaxy-type segregation by splitting the SDSS data into thirds, based on the u*-r* colors of the galaxies, and measure the genus of the reddest and bluest subsamples. This red/blue split in u*-r* is essentially a split by morphology, as explained by Strateva and coworkers. We find that the genus curve for the reddest galaxies exhibits a ``meatball'' shift of the topology-reflecting the concentration of red galaxies in high-density regions-compared to the bluest galaxies and the full sample, in agreement with predictions from simulations.

THE PITTSBURGH SLOAN DIGITAL SKY SURVEY Mg II QUASAR ABSORPTION-LINE SURVEY CATALOG

International Nuclear Information System (INIS)

Quider, Anna M.; Nestor, Daniel B.; Turnshek, David A.; Rao, Sandhya M.; Weyant, Anja N.; Monier, Eric M.; Busche, Joseph R.

2011-01-01

We present a catalog of intervening Mg II quasar absorption-line systems in the redshift interval 0.36 ≤ z ≤ 2.28. The catalog was built from Sloan Digital Sky Survey Data Release Four (SDSS DR4) quasar spectra. Currently, the catalog contains ∼17, 000 measured Mg II doublets. We also present data on the ∼44, 600 quasar spectra which were searched to construct the catalog, including redshift and magnitude information, continuum-normalized spectra, and corresponding arrays of redshift-dependent minimum rest equivalent widths detectable at our confidence threshold. The catalog is available online. A careful second search of 500 random spectra indicated that, for every 100 spectra searched, approximately one significant Mg II system was accidentally rejected. Current plans to expand the catalog beyond DR4 quasars are discussed. Many Mg II absorbers are known to be associated with galaxies. Therefore, the combination of large size and well understood statistics makes this catalog ideal for precision studies of the low-ionization and neutral gas regions associated with galaxies at low to moderate redshift. An analysis of the statistics of Mg II absorbers using this catalog will be presented in a subsequent paper.

THE BLACK HOLE MASS-GALAXY LUMINOSITY RELATIONSHIP FOR SLOAN DIGITAL SKY SURVEY QUASARS

International Nuclear Information System (INIS)

Salviander, S.; Shields, G. A.; Bonning, E. W.

2015-01-01

We investigate the relationship between the mass of the central supermassive black hole, M BH , and the host galaxy luminosity, L gal , in a sample of quasars from the Sloan Digital Sky Survey Data Release 7. We use composite quasar spectra binned by black hole mass and redshift to assess galaxy features that would otherwise be overwhelmed by noise in individual spectra. The black hole mass is calculated using the photoionization method, and the host galaxy luminosity is inferred from the depth of the Ca II H+K features in the composite spectra. We evaluate the evolution in the M BH -L gal relationship by examining the redshift dependence of Δ log M BH , the offset in M BH from the local M BH -L gal relationship. There is little systematic trend in Δ log M BH out to z = 0.8. Using the width of the [O III] emission line as a proxy for the stellar velocity dispersion, σ * , we find agreement of our derived host luminosities with the locally observed Faber-Jackson relation. This supports the utility of the width of the [O III] line as a proxy for σ * in statistical studies

H I-SELECTED GALAXIES IN THE SLOAN DIGITAL SKY SURVEY. I. OPTICAL DATA

International Nuclear Information System (INIS)

West, Andrew A.; Garcia-Appadoo, Diego A.; Dalcanton, Julianne J.; Ivezic, Zeljko; Bentz, Misty C.; Disney, Mike J.; Rockosi, Constance M.; Brinkmann, J.

2010-01-01

We present the optical data for 195 H I-selected galaxies that fall within both the Sloan Digital Sky Survey (SDSS) and the Parkes Equatorial Survey (ES). The photometric quantities have been independently recomputed for our sample using a new photometric pipeline optimized for large galaxies, thus correcting for SDSS's limited reliability for automatic photometry of angularly large or low surface brightness (LSB) galaxies. We outline the magnitude of the uncertainty in the SDSS catalog-level photometry and derive a quantitative method for correcting the over-sky subtraction in the SDSS photometric pipeline. The main thrust of this paper is to present the ES/SDSS sample and discuss the methods behind the improved photometry, which will be used in future scientific analysis. We present the overall optical properties of the sample and briefly compare to a volume-limited, optically selected sample. Compared to the optically selected SDSS sample (in the similar volume), H I-selected galaxies are bluer and more luminous (fewer dwarf ellipticals and more star formation). However, compared to typical SDSS galaxy studies, which have their own selection effect, our sample is bluer, fainter, and less massive.

A Search for Nontoroidal Topological Lensing in the Sloan Digital Sky Survey Quasar Catalog

Science.gov (United States)

Fujii, Hirokazu; Yoshii, Yuzuru

2013-08-01

Flat space models with multiply connected topology, which have compact dimensions, are tested against the distribution of high-redshift (z >= 4) quasars of the Sloan Digital Sky Survey (SDSS). When the compact dimensions are smaller in size than the observed universe, topological lensing occurs, in which multiple images of single objects (ghost images) are observed. We improve on the recently introduced method to identify ghost images by means of four-point statistics. Our method is valid for any of the 17 multiply connected flat models, including nontoroidal ones that are compacted by screw motions or glide reflection. Applying the method to the data revealed one possible case of topological lensing caused by sixth-turn screw motion, however, it is consistent with the simply connected model by this test alone. Moreover, simulations suggest that we cannot exclude the other space models despite the absence of their signatures. This uncertainty mainly originates from the patchy coverage of SDSS in the south Galactic cap, and this situation will be improved by future wide-field spectroscopic surveys.

A SEARCH FOR NONTOROIDAL TOPOLOGICAL LENSING IN THE SLOAN DIGITAL SKY SURVEY QUASAR CATALOG

International Nuclear Information System (INIS)

Fujii, Hirokazu; Yoshii, Yuzuru

2013-01-01

Flat space models with multiply connected topology, which have compact dimensions, are tested against the distribution of high-redshift (z ≥ 4) quasars of the Sloan Digital Sky Survey (SDSS). When the compact dimensions are smaller in size than the observed universe, topological lensing occurs, in which multiple images of single objects (ghost images) are observed. We improve on the recently introduced method to identify ghost images by means of four-point statistics. Our method is valid for any of the 17 multiply connected flat models, including nontoroidal ones that are compacted by screw motions or glide reflection. Applying the method to the data revealed one possible case of topological lensing caused by sixth-turn screw motion, however, it is consistent with the simply connected model by this test alone. Moreover, simulations suggest that we cannot exclude the other space models despite the absence of their signatures. This uncertainty mainly originates from the patchy coverage of SDSS in the south Galactic cap, and this situation will be improved by future wide-field spectroscopic surveys

Preserved learning and memory following 5-fluorouracil and cyclophosphamide treatment in rats.

Science.gov (United States)

Long, Jeffrey M; Lee, Garrick D; Kelley-Bell, Bennett; Spangler, Edward L; Perez, Evelyn J; Longo, Dan L; de Cabo, Rafael; Zou, Sige; Rapp, Peter R

2011-11-01

Some patients experience enduring cognitive impairment after cancer treatment, a condition termed "chemofog". Animal models allow assessment of chemotherapy effects on learning and memory per se, independent of changes due to cancer itself or associated health consequences such as depression. The present study examined the long-term learning and memory effects of a chemotherapy cocktail used widely in the treatment of breast cancer, consisting of 5-fluorouracil (5FU) and cyclophosphamide (CYP). Eighty 5-month old male F344 rats received contextual and cued fear conditioning before treatment with saline, or a low or high dose drug cocktail (50mg/kg CYP and 75 mg/kg 5FU, or 75 mg/kg CYP and 120 mg/kg 5FU, i.p., respectively) every 30 days for 2 months. After a 2-month, no-drug recovery, both long-term retention and new task acquisition in the water maze and 14-unit T-maze were assessed. Neither dose of the CYP/5FU cocktail impaired retrograde fear memory despite marked toxicity documented by enduring weight loss and 50% mortality at the higher dose. Acquisition in the water maze and Stone maze was also normal relative to controls in rats treated with CYP/5FU. The results contribute to a growing literature suggesting that learning and memory mediated by the hippocampus can be relatively resistant to chemotherapy. Future investigation may need to focus on assessments of processing speed, executive function and attention, and the possible interactive contribution of cancer itself and aging to the post-treatment development of cognitive impairment. Copyright © 2011 Elsevier Inc. All rights reserved.

THE SLOAN DIGITAL SKY SURVEY CO-ADD: CROSS-CORRELATION WEAK LENSING AND TOMOGRAPHY OF GALAXY CLUSTERS

International Nuclear Information System (INIS)

Simet, Melanie; Dodelson, Scott; Kubo, Jeffrey M.; Annis, James T.; Hao Jiangang; Johnston, David; Lin, Huan; Soares-Santos, Marcelle; Reis, Ribamar R. R.; Seo, Hee-Jong

2012-01-01

The shapes of distant galaxies are sheared by intervening galaxy clusters. We examine this effect in Stripe 82, a 275 deg 2 region observed multiple times in the Sloan Digital Sky Survey (SDSS) and co-added to achieve greater depth. We obtain a mass-richness calibration that is similar to other SDSS analyses, demonstrating that the co-addition process did not adversely affect the lensing signal. We also propose a new parameterization of the effect of tomography on the cluster lensing signal which does not require binning in redshift, and we show that using this parameterization we can detect tomography for stacked clusters at varying redshifts. Finally, due to the sensitivity of the tomographic detection to accurately marginalize over the effect of the cluster mass, we show that tomography at low redshift (where dependence on exact cosmological models is weak) can be used to constrain mass profiles in clusters.

WE-A-207-00: In Memoriam of Jacques Ovadia - Reinvigorating Scientific Excellence: Electron Beam Therapy - Past, Present and Future

International Nuclear Information System (INIS)

2015-01-01

The Medical Physics community lost one of its early pioneers in radiation oncology physics, Jacques Ovadia, who passed away in April of 2014 at the age of 90. Jacques received his Ph.D. in Nuclear Physics from the University of Illinois at Urbana in 1951. Subsequently, under the guidance of John Laughlin, he was introduced to the field of Medical Physics. When John moved to Memorial Sloan Kettering, Jacques followed him. There he gained clinical experience and expertise in the then cutting-edge field of high energy electron beam therapy. In 1956, Jacques joined Dr. Erich Uhlmann at Michael Reese Hospital in Chicago where one of the country’s first high energy medical linear accelerators had just been installed. During his 35 year tenure, Dr. Ovadia built a strong Medical Physics department that merged in 1984 with that of the University of Chicago. Jacques pioneered the use of high energy electron beams to treat deep seated tumors, multiple-field chest wall irradiation with variable electron energies, and even anticipated the current interest in high energy electron beam grid-therapy. At an early stage, he introduced a simulator, computerized treatment planning and in-house developed record and verify software. He retired in 1990 as Professor emeritus in Radiation and Cellular Biology at the University of Chicago. Dr. Ovadia was an early and strong supporter of AAPM. He was present at the Chicago ROMPS meeting where the decision was made to form an independent professional society for medical physics. He served as AAPM president in 1976. Jacques Ovadia is survived by his wife of 58 years, Florence, their daughter Corinne Graefe and son Marc Ovadia, MD, as well as four grandchildren and one great-grandchild. Jacques’ dynamic and ever enthusiastic personality inspired all who collaborated with him. He will be greatly missed

WE-A-207-00: In Memoriam of Jacques Ovadia - Reinvigorating Scientific Excellence: Electron Beam Therapy - Past, Present and Future

Energy Technology Data Exchange (ETDEWEB)

NONE

2015-06-15

The Medical Physics community lost one of its early pioneers in radiation oncology physics, Jacques Ovadia, who passed away in April of 2014 at the age of 90. Jacques received his Ph.D. in Nuclear Physics from the University of Illinois at Urbana in 1951. Subsequently, under the guidance of John Laughlin, he was introduced to the field of Medical Physics. When John moved to Memorial Sloan Kettering, Jacques followed him. There he gained clinical experience and expertise in the then cutting-edge field of high energy electron beam therapy. In 1956, Jacques joined Dr. Erich Uhlmann at Michael Reese Hospital in Chicago where one of the country’s first high energy medical linear accelerators had just been installed. During his 35 year tenure, Dr. Ovadia built a strong Medical Physics department that merged in 1984 with that of the University of Chicago. Jacques pioneered the use of high energy electron beams to treat deep seated tumors, multiple-field chest wall irradiation with variable electron energies, and even anticipated the current interest in high energy electron beam grid-therapy. At an early stage, he introduced a simulator, computerized treatment planning and in-house developed record and verify software. He retired in 1990 as Professor emeritus in Radiation and Cellular Biology at the University of Chicago. Dr. Ovadia was an early and strong supporter of AAPM. He was present at the Chicago ROMPS meeting where the decision was made to form an independent professional society for medical physics. He served as AAPM president in 1976. Jacques Ovadia is survived by his wife of 58 years, Florence, their daughter Corinne Graefe and son Marc Ovadia, MD, as well as four grandchildren and one great-grandchild. Jacques’ dynamic and ever enthusiastic personality inspired all who collaborated with him. He will be greatly missed.

Neuropsychological profiles of breast cancer and brain tumor cohorts in Northeast Ontario, Canada.

Science.gov (United States)

Mariani, Matias; Collins, Mark William Glister

2018-05-17

As developments in cancer treatment have improved outcomes, research has increasingly focused on the role of cancer-related cognitive impairment (CRCI) in quality of life for cancer survivors. Impairment profiles have been heterogeneous across studies, necessitating the study of these effects across different cohorts. The purpose of this preliminary study is to compare the memory profiles of Northeast Ontario breast and CNS cancer patients, as there is no literature which exists for profiling CRCI within this largely rural region. Sixty-three outpatients with breast cancer (n = 32) or CNS tumors (n = 30) at the Northeast Cancer Centre in Sudbury, Canada, were administered a neuropsychological test battery as part of their clinical examination. Domains measured within this study included attention and concentration, processing speed, motor function, language skills, verbal and visual memory, and executive functioning. Participants with brain tumors scored poorer on most neuropsychological measures than participants with breast cancer. Initial verbal memory for individuals with breast cancer was lower than delayed recall and recognition trials. Trial 1 performance for this group was also negatively correlated with self-reported anxiety scores. Consistent with the literature, participants with breast cancer obtained higher scores on most test measures than participants with CNC tumors. Breast cancer participants had lower verbal memory scores on initial trials compared to delayed recall, potentially due to relationships with anxiety and attention. Further research into this cohort will strive to gain greater understanding of the patterns of deficits experienced and how these may inform individuals with cancer in other regions.

INNOCENT BYSTANDERS: CARBON STARS FROM THE SLOAN DIGITAL SKY SURVEY

International Nuclear Information System (INIS)

Green, Paul

2013-01-01

Among stars showing carbon molecular bands (C stars), the main-sequence dwarfs, likely in post-mass transfer binaries, are numerically dominant in the Galaxy. Via spectroscopic selection from the Sloan Digital Sky Survey, we retrieve 1220 high galactic latitude C stars, ∼5 times more than previously known, including a wider variety than past techniques such as color or grism selection have netted, and additionally yielding 167 DQ white dwarfs. Of the C stars with proper motion measurements, we identify 69% clearly as dwarfs (dCs), while ∼7% are giants. The dCs likely span absolute magnitudes M i from ∼6.5 to 10.5. 'G-type' dC stars with weak CN and relatively blue colors are probably the most massive dCs still cool enough to show C 2 bands. We report Balmer emission in 22 dCs, none of which are G-types. We find 8 new DA/dC stars in composite spectrum binaries, quadrupling the total sample of these 'smoking guns' for AGB binary mass transfer. Eleven very red C stars with strong red CN bands appear to be 'N'-type AGB stars at large Galactocentric distances, one likely a new discovery in the dIrr galaxy Leo A. Two such stars within 30' of each other may trace a previously unidentified dwarf galaxy or tidal stream at ∼40 kpc. We explore the multiwavelength properties of the sample and report the first X-ray detection of a dC star, which shows strong Balmer emission. Our own spectroscopic survey additionally provides the dC surface density from a complete sample of dwarfs limited by magnitude, color, and proper motion.

Innocent Bystanders: Carbon Stars from the Sloan Digital Sky Survey

Science.gov (United States)

Green, Paul

2013-03-01

Among stars showing carbon molecular bands (C stars), the main-sequence dwarfs, likely in post-mass transfer binaries, are numerically dominant in the Galaxy. Via spectroscopic selection from the Sloan Digital Sky Survey, we retrieve 1220 high galactic latitude C stars, ~5 times more than previously known, including a wider variety than past techniques such as color or grism selection have netted, and additionally yielding 167 DQ white dwarfs. Of the C stars with proper motion measurements, we identify 69% clearly as dwarfs (dCs), while ~7% are giants. The dCs likely span absolute magnitudes Mi from ~6.5 to 10.5. "G-type" dC stars with weak CN and relatively blue colors are probably the most massive dCs still cool enough to show C2 bands. We report Balmer emission in 22 dCs, none of which are G-types. We find 8 new DA/dC stars in composite spectrum binaries, quadrupling the total sample of these "smoking guns" for AGB binary mass transfer. Eleven very red C stars with strong red CN bands appear to be "N"-type AGB stars at large Galactocentric distances, one likely a new discovery in the dIrr galaxy Leo A. Two such stars within 30' of each other may trace a previously unidentified dwarf galaxy or tidal stream at ~40 kpc. We explore the multiwavelength properties of the sample and report the first X-ray detection of a dC star, which shows strong Balmer emission. Our own spectroscopic survey additionally provides the dC surface density from a complete sample of dwarfs limited by magnitude, color, and proper motion.

C IV BROAD ABSORPTION LINE ACCELERATION IN SLOAN DIGITAL SKY SURVEY QUASARS

Energy Technology Data Exchange (ETDEWEB)

Grier, C. J.; Brandt, W. N.; Trump, J. R.; Schneider, D. P.; Sun, M.; Beatty, T. G. [Department of Astronomy and Astrophysics, The Pennsylvania State University, 525 Davey Laboratory, University Park, PA 16802 (United States); Hall, P. B. [Department of Physics and Astronomy, York University, Toronto, ON M3J 1P3 (Canada); Filiz Ak, N. [Faculty of Sciences, Department of Astronomy and Space Sciences, Erciyes University, 38039 Kayseri (Turkey); Anderson, S. F. [Department of Astronomy, University of Washington, Box 351580, Seattle, WA 98195 (United States); Green, Paul J. [Harvard Smithsonian Center for Astrophysics, 60 Garden St, Cambridge, MA 02138 (United States); Vivek, M.; Brownstein, Joel R. [Department of Physics and Astronomy, University of Utah, 115 S. 1400 E., Salt Lake City, UT 84112 (United States); Roman-Lopes, Alexandre, E-mail: grier@psu.edu [Departamento de Fisica, Facultad de Ciencias, Universidad de La Serena, Cisternas 1200, La Serena (Chile)

2016-06-20

We present results from the largest systematic investigation of broad absorption line (BAL) acceleration to date. We use spectra of 140 quasars from three Sloan Digital Sky Survey programs to search for global velocity offsets in BALs over timescales of ≈2.5–5.5 years in the quasar rest frame. We carefully select acceleration candidates by requiring monolithic velocity shifts over the entire BAL trough, avoiding BALs with velocity shifts that might be caused by profile variability. The C iv BALs of two quasars show velocity shifts consistent with the expected signatures of BAL acceleration, and the BAL of one quasar shows a velocity-shift signature of deceleration. In our two acceleration candidates, we see evidence that the magnitude of the acceleration is not constant over time; the magnitudes of the change in acceleration for both acceleration candidates are difficult to produce with a standard disk-wind model or via geometric projection effects. We measure upper limits to acceleration and deceleration for 76 additional BAL troughs and find that the majority of BALs are stable to within about 3% of their mean velocities. The lack of widespread acceleration/deceleration could indicate that the gas producing most BALs is located at large radii from the central black hole and/or is not currently strongly interacting with ambient material within the host galaxy along our line of sight.

High-Redshift Quasars Found in Sloan Digital Sky Survey Commissioning Data. II. The Spring Equatorial Stripe

International Nuclear Information System (INIS)

Fan, Xiaohui; Strauss, Michael A.; Schneider, Donald P.; Gunn, James E.; Lupton, Robert H.; Anderson, Scott F.; Voges, Wolfgang; Margon, Bruce; Annis, James; Bahcall, Neta A.

2000-01-01

This is the second paper in a series aimed at finding high-redshift quasars from five-color (u ' g ' r ' i ' z ' ) imaging data taken along the Celestial Equator by the Sloan Digital Sky Survey (SDSS) during its commissioning phase. In this paper, we present 22 high-redshift quasars (z>3.6) discovered from ∼250 deg2 of data in the spring Equatorial Stripe, plus photometry for two previously known high-redshift quasars in the same region of the sky. Our success rate in identifying high-redshift quasars is 68%. Five of the newly discovered quasars have redshifts higher than 4.6 (z=4.62, 4.69, 4.70, 4.92, and 5.03). All the quasars have i * B 0 =0.5). Several of the quasars show unusual emission and absorption features in their spectra, including an object at z=4.62 without detectable emission lines, and a broad absorption line (BAL) quasar at z=4.92. (c) (c) 2000. The American Astronomical Society

THE SLOAN DIGITAL SKY SURVEY QUASAR LENS SEARCH. V. FINAL CATALOG FROM THE SEVENTH DATA RELEASE

International Nuclear Information System (INIS)

Inada, Naohisa; Oguri, Masamune; Kayo, Issha; Fukugita, Masataka; Shin, Min-Su; Strauss, Michael A.; Bahcall, Neta A.; Morokuma, Tomoki; Rusu, Cristian E.; Kochanek, Christopher S.; Richards, Gordon T.; Schneider, Donald P.; York, Donald G.; Frieman, Joshua A.; Hall, Patrick B.; White, Richard L.

2012-01-01

We present the final statistical sample of lensed quasars from the Sloan Digital Sky Survey (SDSS) Quasar Lens Search (SQLS). The well-defined statistical lens sample consists of 26 lensed quasars brighter than i = 19.1 and in the redshift range of 0.6 < z < 2.2 selected from 50,826 spectroscopically confirmed quasars in the SDSS Data Release 7 (DR7), where we restrict the image separation range to 1'' < θ < 20'' and the i-band magnitude differences in two images to be smaller than 1.25 mag. The SDSS DR7 quasar catalog also contains 36 additional lenses identified with various techniques. In addition to these lensed quasars, we have identified 81 pairs of quasars from follow-up spectroscopy, 26 of which are physically associated binary quasars. The statistical lens sample covers a wide range of image separations, redshifts, and magnitudes, and therefore is suitable for systematic studies of cosmological parameters and surveys of the structure and evolution of galaxies and quasars.

Memory in pediatric patients undergoing conscious sedation for aversive medical procedures.

Science.gov (United States)

Pringle, Beverly; Dahlquist, Lynnda M; Eskenazi, Allen

2003-05-01

This study investigated preserved memory in 26 pediatric cancer patients (65% boys, 77% Caucasian, mean age = 12.5 years) undergoing midazolam-induced conscious sedation during painful medical procedures to treat hematological or oncological diseases. The sedative midazolam had a significant anterograde amnesic effect on participants' performance on a visual recognition (explicit) memory task but not on a visual perceptual facilitation (implicit) memory task. That implicit memory scores were relatively unaffected while explicit memory scores deteriorated significantly indicates that leaning occurred while participants were sedated, even when participants did not recollect the learning event. These findings, which replicate those of M. R. Polster, R. A. McCarthy, G. O'Sullivan, P. A. Gray, and G. R. Park (1993) in a study of adults, have implications for the development and treatment of conditioned anxiety reactions associated with aversive medical procedures.

The Discovery of a Luminous Z=5.80 Quasar from the Sloan Digital Sky Survey

Science.gov (United States)

Fan, Xiaohui; White, Richard L.; Davis, Marc; Becker, Robert H.; Strauss, Michael A.; Haiman, Zoltan; Schneider, Donald P.; Gregg, Michael D.; Gunn, James E.; Knapp, G. R.; Lupton, Robert H.; Anderson, John E., Jr.; Anderson, Scott F.; Annis, James; Bahcall, Neta A.; Boroski, William N.; Brunner, Robert J.; Chen, Bing; Connolly, Andrew J.; Csabai, István; Doi, Mamoru; Fukugita, Masataka; Hennessy, G. S.; Hindsley, Robert B.; Ichikawa, Takashi; Ivezić, Željko; Loveday, Jon; Meiksin, Avery; McKay, Timothy A.; Munn, Jeffrey A.; Newberg, Heidi Jo; Nichol, Robert; Okamura, Sadanori; Pier, Jeffrey R.; Sekiguchi, Maki; Shimasaku, Kazuhiro; Stoughton, Chris; Szalay, Alexander S.; Szokoly, Gyula P.; Thakar, Aniruddha R.; Vogeley, Michael S.; York, Donald G.

2000-09-01

We present observations of SDSSp J104433.04-012502.2, a luminous quasar at z=5.80 discovered from Sloan Digital Sky Survey (SDSS) multicolor imaging data. This object was selected as an i'-band dropout object, with i*=21.8+/-0.2 and z*=19.2+/-0.1. It has an absolute magnitude M1450=-27.2 (H0=50 km s-1 Mpc-1, q0=0.5). The spectrum shows a strong and broad Lyα emission line, strong Lyα forest absorption lines with a mean continuum decrement DA=0.91 and a Lyman limit system at z=5.72. The spectrum also shows strong O I and Si IV emission lines similar to those of quasars at zuniverse is already highly ionized at z~5.8. Using a high-resolution spectrum in the Lyα forest region, we place a conservative upper limit on the optical depth because of the Gunn-Peterson effect of τUniversity of California, and NASA, and was made possible by the generous financial support of the W. M. Keck Foundation.

Red Misfits in the Sloan Digital Sky Survey: properties of star-forming red galaxies

Science.gov (United States)

Evans, Fraser A.; Parker, Laura C.; Roberts, Ian D.

2018-06-01

We study Red Misfits, a population of red, star-forming galaxies in the local Universe. We classify galaxies based on inclination-corrected optical colours and specific star formation rates derived from the Sloan Digital Sky Survey Data Release 7. Although the majority of blue galaxies are star-forming and most red galaxies exhibit little to no ongoing star formation, a small but significant population of galaxies (˜11 per cent at all stellar masses) are classified as red in colour yet actively star-forming. We explore a number of properties of these galaxies and demonstrate that Red Misfits are not simply dusty or highly inclined blue cloud galaxies or quiescent red galaxies with poorly constrained star formation. The proportion of Red Misfits is nearly independent of environment, and this population exhibits both intermediate morphologies and an enhanced likelihood of hosting an active galactic nucleus. We conclude that Red Misfits are a transition population, gradually quenching on their way to the red sequence and this quenching is dominated by internal processes rather than environmentally driven processes. We discuss the connection between Red Misfits and other transition galaxy populations, namely S0s, red spirals, and green valley galaxies.

THE SLOAN DIGITAL SKY SURVEY DATA RELEASE 7 SPECTROSCOPIC M DWARF CATALOG. I. DATA

International Nuclear Information System (INIS)

West, Andrew A.; Morgan, Dylan P.; Andersen, Jan Marie; Covey, Kevin R.; Schluns, Kyle; Jones, David O.; Bochanski, John J.; Pineda, J. Sebastian; Bell, Keaton J.; Kowalski, Adam F.; Davenport, James R. A.; Hawley, Suzanne L.; Schmidt, Sarah J.; Hilton, Eric J.; Bernat, David; Muirhead, Philip; Rojas-Ayala, Barbara; Schlawin, Everett; Gooding, Mary; Dhital, Saurav

2011-01-01

We present a spectroscopic catalog of 70,841 visually inspected M dwarfs from the seventh data release of the Sloan Digital Sky Survey. For each spectrum, we provide measurements of the spectral type, a number of molecular band heads, and the Hα, Hβ, Hγ, Hδ, and Ca II K emission lines. In addition, we calculate the metallicity-sensitive parameter ζ and identify a relationship between ζ and the g - r and r - z colors of M dwarfs. We assess the precision of our spectral types (which were assigned by individual examination), review the bulk attributes of the sample, and examine the magnetic activity properties of M dwarfs, in particular those traced by the higher order Balmer transitions. Our catalog is cross-matched to Two Micron All Sky Survey infrared data, and contains photometric distances for each star. Finally, we identify eight new late-type M dwarfs that are possibly within 25 pc of the Sun. Future studies will use these data to thoroughly examine magnetic activity and kinematics in late-type M dwarfs and examine the chemical and dynamical history of the local Milky Way.

COMMON PROPER-MOTION WIDE WHITE DWARF BINARIES SELECTED FROM THE SLOAN DIGITAL SKY SURVEY

International Nuclear Information System (INIS)

Andrews, Jeff J.; Agüeros, Marcel A.; Belczynski, Krzysztof; Dhital, Saurav; Kleinman, S. J.; West, Andrew A.

2012-01-01

Wide binaries made up of two white dwarfs (WDs) receive far less attention than their tight counterparts. However, our tests using the binary population synthesis code StarTrack indicate that, for any set of reasonable initial conditions, there exists a significant observable population of double white dwarfs (WDWDs) with orbital separations of 10 2 -10 5 AU. We adapt the technique of Dhital et al. to search for candidate common proper-motion WD companions separated by 12,000 spectroscopically confirmed hydrogen-atmosphere WDs recently identified in the Sloan Digital Sky Survey. Using two techniques to separate random alignments from high-confidence pairs, we find nine new high-probability wide WDWDs and confirm three previously identified candidate wide WDWDs. This brings the number of known wide WDWDs to 45; our new pairs are a significant addition to the sample, especially at small proper motions ( –1 ) and large angular separations (>10''). Spectroscopic follow-up and an extension of this method to a larger, photometrically selected set of SDSS WDs may eventually produce a large enough dataset for WDWDs to realize their full potential as testbeds for theories of stellar evolution.

Prospective memory, working memory, retrospective memory and self-rated memory performance in persons with intellectual disability

OpenAIRE

Levén, Anna; Lyxell, Björn; Andersson, Jan; Danielsson, Henrik; Rönnberg, Jerker

2008-01-01

The purpose of the present study was to examine the relationship between prospective memory, working memory, retrospective memory and self-rated memory capacity in adults with and without intellectual disability. Prospective memory was investigated by means of a picture-based task. Working memory was measured as performance on span tasks. Retrospective memory was scored as recall of subject performed tasks. Self-ratings of memory performance were based on the prospective and retrospective mem...

A CATALOG OF DETAILED VISUAL MORPHOLOGICAL CLASSIFICATIONS FOR 14,034 GALAXIES IN THE SLOAN DIGITAL SKY SURVEY

International Nuclear Information System (INIS)

Nair, Preethi B.; Abraham, Roberto G.

2010-01-01

We present a catalog of detailed visual classifications for 14,034 galaxies in the Sloan Digital Sky Survey (SDSS) Data Release 4 (DR4). Our sample includes nearly all spectroscopically targeted galaxies in the redshift range 0.01 < z < 0.1 down to an apparent extinction-corrected limit of g < 16 mag. In addition to T-Types, we record the existence of bars, rings, lenses, tails, warps, dust lanes, arm flocculence, and multiplicity. This sample defines a comprehensive local galaxy sample which we will use in future papers to study low-redshift morphology. It will also prove useful for calibrating automated galaxy classification algorithms. In this paper, we describe the classification methodology used, detail the systematics and biases of our sample, and summarize the overall statistical properties of the sample, noting the most obvious trends that are relevant for general comparisons of our catalog with previously published work.

Exploring the diffuse interstellar bands with the Sloan Digital Sky Survey

Science.gov (United States)

Lan, Ting-Wen; Ménard, Brice; Zhu, Guangtun

2015-10-01

We use star, galaxy and quasar spectra taken by the Sloan Digital Sky Survey to map out the distribution of diffuse interstellar bands (DIBs) induced by the Milky Way. After carefully removing the intrinsic spectral energy distribution of each source, we show that by stacking thousands of spectra, it is possible to measure statistical flux fluctuations at the 10-3 level, detect more than 20 DIBs and measure their strength as a function of position on the sky. We create a map of DIB absorption covering about 5000 deg2 and measure correlations with various tracers of the interstellar medium: atomic and molecular hydrogen, dust and polycyclic aromatic hydrocarbons (PAHs). After recovering known correlations, we show that each DIB has a different dependence on atomic and molecular hydrogen: while they are all positively correlated with N_{H I}, they exhibit a range of behaviours with N_{H_2} showing positive, negative or no correlation. We show that a simple parametrization involving only N_{H I} and N_{H_2} applied to all the DIBs is sufficient to reproduce a large collection of observational results reported in the literature: it allows us to naturally describe the relations between DIB strength and dust reddening (including the so-called skin effect), the related scatter, DIB pair-wise correlations and families, the affinity for σ/ζ-type environments and other correlations related to molecules. Our approach allows us to characterize DIB dependencies in a simple manner and provides us with a metric to characterize the similarity between different DIBs.

INNOCENT BYSTANDERS: CARBON STARS FROM THE SLOAN DIGITAL SKY SURVEY

Energy Technology Data Exchange (ETDEWEB)

Green, Paul [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States)

2013-03-01

Among stars showing carbon molecular bands (C stars), the main-sequence dwarfs, likely in post-mass transfer binaries, are numerically dominant in the Galaxy. Via spectroscopic selection from the Sloan Digital Sky Survey, we retrieve 1220 high galactic latitude C stars, {approx}5 times more than previously known, including a wider variety than past techniques such as color or grism selection have netted, and additionally yielding 167 DQ white dwarfs. Of the C stars with proper motion measurements, we identify 69% clearly as dwarfs (dCs), while {approx}7% are giants. The dCs likely span absolute magnitudes M{sub i} from {approx}6.5 to 10.5. 'G-type' dC stars with weak CN and relatively blue colors are probably the most massive dCs still cool enough to show C{sub 2} bands. We report Balmer emission in 22 dCs, none of which are G-types. We find 8 new DA/dC stars in composite spectrum binaries, quadrupling the total sample of these 'smoking guns' for AGB binary mass transfer. Eleven very red C stars with strong red CN bands appear to be 'N'-type AGB stars at large Galactocentric distances, one likely a new discovery in the dIrr galaxy Leo A. Two such stars within 30' of each other may trace a previously unidentified dwarf galaxy or tidal stream at {approx}40 kpc. We explore the multiwavelength properties of the sample and report the first X-ray detection of a dC star, which shows strong Balmer emission. Our own spectroscopic survey additionally provides the dC surface density from a complete sample of dwarfs limited by magnitude, color, and proper motion.

Correlations among Galaxy Properties from the Sloan Digital Sky Survey

Science.gov (United States)

Li, Zhongmu; Mao, Caiyan

2013-07-01

Galaxies are complex systems with many properties. Correlations among galaxy properties can supply important clues for studying the formation and evolution of galaxies. Using principal component analysis and least-squares fitting, this paper investigates the correlations among galactic parameters involving more properties (color, morphology, stellar population, and absolute magnitude) than previous studies. We use a volume-limited sample (whole sample) of 75,423 galaxies that was selected from the Sloan Digital Sky Survey Data Release 2 and divided into two subsamples (blue and red samples) using a critical color of (g - r) = 0.70 mag. In addition to recovering some previous results, we also obtain some new results. First, all separators for dividing galaxies into two groups can be related via good parameter-first principal component (PC1) correlations. A critical PC1 that indicates whether or not stellar age (or the evolution of a stellar population over time) is important can be used to separate galaxies. This suggests that a statistical parameter, PC1, is helpful in understanding the physical separators of galaxies. In addition, stellar age is shown to be unimportant for red galaxies, while both stellar age and mass are dominating parameters of blue galaxies. This suggests that the various numbers of dominating parameters of galaxies may result from the use of different samples. Finally, some parameters are shown to be correlated, and quantitative fits for a few correlations are obtained, e.g., log(t) = 8.57 + 1.65 (g - r) for the age (log t) and color (g - r) of blue galaxies and log (M *) = 4.31 - 0.30 M r for the stellar mass (log M *) and absolute magnitude (M r) of red galaxies. The median relationships between various parameter pairs are also presented for comparison.

The Sloan Digital Sky Survey Quasar Catalog: Fourteenth data release

Science.gov (United States)

Pâris, Isabelle; Petitjean, Patrick; Aubourg, Éric; Myers, Adam D.; Streblyanska, Alina; Lyke, Brad W.; Anderson, Scott F.; Armengaud, Éric; Bautista, Julian; Blanton, Michael R.; Blomqvist, Michael; Brinkmann, Jonathan; Brownstein, Joel R.; Brandt, William Nielsen; Burtin, Étienne; Dawson, Kyle; de la Torre, Sylvain; Georgakakis, Antonis; Gil-Marín, Héctor; Green, Paul J.; Hall, Patrick B.; Kneib, Jean-Paul; LaMassa, Stephanie M.; Le Goff, Jean-Marc; MacLeod, Chelsea; Mariappan, Vivek; McGreer, Ian D.; Merloni, Andrea; Noterdaeme, Pasquier; Palanque-Delabrouille, Nathalie; Percival, Will J.; Ross, Ashley J.; Rossi, Graziano; Schneider, Donald P.; Seo, Hee-Jong; Tojeiro, Rita; Weaver, Benjamin A.; Weijmans, Anne-Marie; Yèche, Christophe; Zarrouk, Pauline; Zhao, Gong-Bo

2018-05-01

We present the data release 14 Quasar catalog (DR14Q) from the extended Baryon Oscillation Spectroscopic Survey (eBOSS) of the Sloan Digital Sky Survey IV (SDSS-IV). This catalog includes all SDSS-IV/eBOSS objects that were spectroscopically targeted as quasar candidates and that are confirmed as quasars via a new automated procedure combined with a partial visual inspection of spectra, have luminosities Mi [z = 2] < -20.5 (in a Λ CDM cosmology with H0 = 70 km s-1 Mpc-1, Ω M =0.3, and Ω Λ = 0.7), and either display at least one emission line with a full width at half maximum larger than 500 km s-1 or, if not, have interesting/complex absorption features. The catalog also includes previously spectroscopically-confirmed quasars from SDSS-I, II, and III. The catalog contains 526 356 quasars (144 046 are new discoveries since the beginning of SDSS-IV) detected over 9376 deg2 (2044 deg2 having new spectroscopic data available) with robust identification and redshift measured by a combination of principal component eigenspectra. The catalog is estimated to have about 0.5% contamination. Redshifts are provided for the Mg II emission line. The catalog identifies 21 877 broad absorption line quasars and lists their characteristics. For each object, the catalog presents five-band (u, g, r, i, z) CCD-based photometry with typical accuracy of 0.03 mag. The catalog also contains X-ray, ultraviolet, near-infrared, and radio emission properties of the quasars, when available, from other large-area surveys. The calibrated digital spectra, covering the wavelength region 3610-10 140 Å at a spectral resolution in the range 1300 < R < 2500, can be retrieved from the SDSS Science Archiver Server. http://www.sdss.org/dr14/algorithms/qso_catalog

A high-resolution atlas of composite Sloan Digital Sky Survey galaxy spectra

Science.gov (United States)

Dobos, László; Csabai, István.; Yip, Ching-Wa; Budavári, Tamás.; Wild, Vivienne; Szalay, Alexander S.

2012-02-01

In this work we present an atlas of composite spectra of galaxies based on the data of the Sloan Digital Sky Survey Data Release 7 (SDSS DR7). Galaxies are classified by colour, nuclear activity and star formation activity to calculate average spectra of high signal-to-noise ratio (S/N) and resolution (? at Δλ= 1 Å), using an algorithm that is robust against outliers. Besides composite spectra, we also compute the first five principal components of the distributions in each galaxy class to characterize the nature of variations of individual spectra around the averages. The continua of the composite spectra are fitted with BC03 stellar population synthesis models to extend the wavelength coverage beyond the coverage of the SDSS spectrographs. Common derived parameters of the composites are also calculated: integrated colours in the most popular filter systems, line-strength measurements and continuum absorption indices (including Lick indices). These derived parameters are compared with the distributions of parameters of individual galaxies, and it is shown on many examples that the composites of the atlas cover much of the parameter space spanned by SDSS galaxies. By co-adding thousands of spectra, a total integration time of several months can be reached, which results in extremely low noise composites. The variations in redshift not only allow for extending the spectral coverage bluewards to the original wavelength limit of the SDSS spectrographs, but also make higher spectral resolution achievable. The composite spectrum atlas is available online at .

The Low-Resolution Spectrograph of the Hobby-Eberly Telescope. II. Observations of Quasar Candidates from the Sloan Digital Sky Survey

International Nuclear Information System (INIS)

Schneider, D. P.; Hill, Gary J.; Fan, X.; Ramsey, L. W.; MacQueen, P. J.; Weedman, D. W.; Booth, J. A.; Eracleous, M.; Gunn, J. E.; Lupton, R. H.

2000-01-01

This paper describes spectra of quasar candidates acquired during the commissioning phase of the Low-Resolution Spectrograph of the Hobby-Eberly Telescope. The objects were identified as possible quasars from multicolor image data from the Sloan Digital Sky Survey. The 10 sources had typical r' magnitudes of 19-20, except for one extremely red object with r ' ≅23. The data, obtained with exposure times between 10 and 25 minutes, reveal that the spectra of four candidates are essentially featureless and are not quasars, five are quasars with redshifts between 2.92 and 4.15 (including one broad absorption line quasar), and the red source is a very late M star or early L dwarf. (c) (c) 2000. The Astronomical Society of the Pacific

Laser memory (hologram) and coincident redundant multiplex memory (CRM-memory)

International Nuclear Information System (INIS)

Ostojic, Branko

1975-01-01

It is shown that besides the memory which remembers the object by memorising of the phases of the interferenting waves of the light (i.e. hologram) it is possible to construct the memory which remembers the object by memorising of the phases of the interferenting impulses (CFM-memory). It is given the mathematical description of the memory, based on the experimental model. Although in the paper only the technical aspect of CRM memory is given. It is mentioned the possibility that the human memory has the same principle and that the invention of CRM memory is due to cybernetical analysis of the system human eye-visual cortex

THE SLOAN DIGITAL SKY SURVEY QUASAR LENS SEARCH. IV. STATISTICAL LENS SAMPLE FROM THE FIFTH DATA RELEASE

International Nuclear Information System (INIS)

Inada, Naohisa; Oguri, Masamune; Shin, Min-Su; Kayo, Issha; Fukugita, Masataka; Strauss, Michael A.; Gott, J. Richard; Hennawi, Joseph F.; Morokuma, Tomoki; Becker, Robert H.; Gregg, Michael D.; White, Richard L.; Kochanek, Christopher S.; Chiu, Kuenley; Johnston, David E.; Clocchiatti, Alejandro; Richards, Gordon T.; Schneider, Donald P.; Frieman, Joshua A.

2010-01-01

We present the second report of our systematic search for strongly lensed quasars from the data of the Sloan Digital Sky Survey (SDSS). From extensive follow-up observations of 136 candidate objects, we find 36 lenses in the full sample of 77,429 spectroscopically confirmed quasars in the SDSS Data Release 5. We then define a complete sample of 19 lenses, including 11 from our previous search in the SDSS Data Release 3, from the sample of 36,287 quasars with i Λ = 0.84 +0.06 -0.08 (stat.) +0.09 -0.07 (syst.) assuming a flat universe, which is in good agreement with other cosmological observations. We also report the discoveries of seven binary quasars with separations ranging from 1.''1 to 16.''6, which are identified in the course of our lens survey. This study concludes the construction of our statistical lens sample in the full SDSS-I data set.

Young stellar populations in early-type galaxies in the Sloan Digital Sky Survey

Science.gov (United States)

Nolan, Louisa A.; Raychaudhury, Somak; Kabán, Ata

2007-02-01

We use a purely data-driven rectified factor analysis to identify early-type galaxies with recent star formation in Data Release 4 of the Sloan Digital Sky Survey Spectroscopic Catalogue. We compare the spectra and environment of these galaxies with those of `normal' early-type galaxies, and a sample of independently selected E+A galaxies. We calculate the projected local galaxy surface density from the nearest five and 10 neighbours (Σ5 and Σ10) for each galaxy in our sample, and find that the dependence on projected local density, of the properties of E+A galaxies, is not significantly different from that of early-type galaxies with young stellar populations, dropping off rapidly towards denser environments, and flattening off at densities ~10 per cent of the stellar mass in these galaxies. This, together with the similarity of the environments in which this `E+F' population and the E+A galaxy sample are found, suggests that E+F galaxies used to be E+A galaxies, but have evolved by a further ~ one to a few Gyr. Our rectified factor analysis is sensitive enough to identify this hidden population, which allows us to study the global and intrinsic properties of early-type galaxies created in major mergers or interactions, and compare them with those early-types which have had the bulk of their stars in place since a much earlier epoch.

The Sloan Digital Sky Survey Quasar Catalog. 3. Third data release

Energy Technology Data Exchange (ETDEWEB)

Schneider, Donald P.; Hall, Patrick B.; Richards, Gordon T.; Vanden Berk, Daniel E.; Anderson, Scott F.; Fan, Xiao-Hui; Jester, Sebastian; Stoughton, Chris; Strauss,; SubbaRao, Mark; Brandt, W.N.; Gunn, James E.; Yanny, Brian; Bahcall, Neta A.; Barentine, J.C.; Blanton, Michael R.; Boroski, William N.; Brewington, Howard J.; Brinkmann, J.; Brunner, Robert; Csabai, Istvan; /Penn State U., Astron. Astrophys. /York U., Canada /Princeton U. Observ. /Washington U., Seattle, Astron. Dept. /Arizona U.,

2005-03-01

We present the third edition of the Sloan Digital Sky Survey (SDSS) Quasar Catalog. The catalog consists of the 46,420 objects in the SDSS Third Data Release that have luminosities larger than M{sub i} = -22 (in a cosmology with H{sub 0} = 70 km s{sup -1} Mpc{sup -1}, {Omega}{sub M} = 0.3, and {Omega}{sub {Lambda}} = 0.7), have at least one emission line with FWHM larger than 1000 km s{sup -1} or are unambiguously broad absorption line quasars, are fainter than i = 15.0, and have highly reliable redshifts. The area covered by the catalog is {approx} 4188 deg{sup 2}. The quasar redshifts range from 0.08 to 5.41, with a median value of 1.47; the high-redshift sample includes 520 quasars at redshifts greater than four, of which 17 are at redshifts greater than five. For each object the catalog presents positions accurate to better than 0.2'' rms per coordinate, five-band (ugriz) CCD-based photometry with typical accuracy of 0.03 mag, and information on the morphology and selection method. The catalog also contains radio, near-infrared, and X-ray emission properties of the quasars, when available, from other large-area surveys. The calibrated digital spectra cover the wavelength region 3800-9200 at a spectral resolution of {approx} 2000; the spectra can be retrieved from the public database using the information provided in the catalog. A total of 44,221 objects in the catalog were discovered by the SDSS; 28,400 of the SDSS discoveries are reported here for the first time.

Episodic memory, semantic memory, and amnesia.

Science.gov (United States)

Squire, L R; Zola, S M

1998-01-01

Episodic memory and semantic memory are two types of declarative memory. There have been two principal views about how this distinction might be reflected in the organization of memory functions in the brain. One view, that episodic memory and semantic memory are both dependent on the integrity of medial temporal lobe and midline diencephalic structures, predicts that amnesic patients with medial temporal lobe/diencephalic damage should be proportionately impaired in both episodic and semantic memory. An alternative view is that the capacity for semantic memory is spared, or partially spared, in amnesia relative to episodic memory ability. This article reviews two kinds of relevant data: 1) case studies where amnesia has occurred early in childhood, before much of an individual's semantic knowledge has been acquired, and 2) experimental studies with amnesic patients of fact and event learning, remembering and knowing, and remote memory. The data provide no compelling support for the view that episodic and semantic memory are affected differently in medial temporal lobe/diencephalic amnesia. However, episodic and semantic memory may be dissociable in those amnesic patients who additionally have severe frontal lobe damage.

Selective impact of disease on short-term and long-term components of self-reported memory: a population-based HUNT study.

Science.gov (United States)

Almkvist, Ove; Bosnes, Ole; Bosnes, Ingunn; Stordal, Eystein

2017-05-09

Subjective memory is commonly considered to be a unidimensional measure. However, theories of performance-based memory suggest that subjective memory could be divided into more than one dimension. To divide subjective memory into theoretically related components of memory and explore the relationship to disease. In this study, various aspects of self-reported memory were studied with respect to demographics and diseases in the third wave of the HUNT epidemiological study in middle Norway. The study included all individuals 55 years of age or older, who responded to a nine-item questionnaire on subjective memory and questionnaires on health (n=18 633). A principle component analysis of the memory items resulted in two memory components; the criterion used was an eigenvalue above 1, which accounted for 54% of the total variance. The components were interpreted as long-term memory (LTM; the first component; 43% of the total variance) and short-term memory (STM; the second component; 11% of the total variance). Memory impairment was significantly related to all diseases (except Bechterew's disease), most strongly to brain infarction, heart failure, diabetes, cancer, chronic obstructive pulmonary disease and whiplash. For most diseases, the STM component was more affected than the LTM component; however, in cancer, the opposite pattern was seen. Subjective memory impairment as measured in HUNT contained two components, which were differentially associated with diseases. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

COMMON PROPER-MOTION WIDE WHITE DWARF BINARIES SELECTED FROM THE SLOAN DIGITAL SKY SURVEY

Energy Technology Data Exchange (ETDEWEB)

Andrews, Jeff J.; Agueeros, Marcel A. [Department of Astronomy, Columbia University, 550 West 120th Street, New York, NY 10027 (United States); Belczynski, Krzysztof [Astronomical Observatory, University of Warsaw, Al. Ujazdowskie 4, 00-478 Warsaw (Poland); Dhital, Saurav [Department of Physics and Astronomy, Vanderbilt University, 6301 Stevenson Center, Nashville, TN 37235 (United States); Kleinman, S. J. [Gemini Observatory, Northern Operations Center, Hilo, HI 96720 (United States); West, Andrew A. [Department of Astronomy, Boston University, 725 Commonwealth Ave, Boston, MA 02215 (United States)

2012-10-01

Wide binaries made up of two white dwarfs (WDs) receive far less attention than their tight counterparts. However, our tests using the binary population synthesis code StarTrack indicate that, for any set of reasonable initial conditions, there exists a significant observable population of double white dwarfs (WDWDs) with orbital separations of 10{sup 2}-10{sup 5} AU. We adapt the technique of Dhital et al. to search for candidate common proper-motion WD companions separated by <10' around the >12,000 spectroscopically confirmed hydrogen-atmosphere WDs recently identified in the Sloan Digital Sky Survey. Using two techniques to separate random alignments from high-confidence pairs, we find nine new high-probability wide WDWDs and confirm three previously identified candidate wide WDWDs. This brings the number of known wide WDWDs to 45; our new pairs are a significant addition to the sample, especially at small proper motions (<200 mas yr{sup -1}) and large angular separations (>10''). Spectroscopic follow-up and an extension of this method to a larger, photometrically selected set of SDSS WDs may eventually produce a large enough dataset for WDWDs to realize their full potential as testbeds for theories of stellar evolution.

Relationship between self-reported and objectively measured physical activity and subjective memory impairment in breast cancer survivors: role of self-efficacy, fatigue and distress.

Science.gov (United States)

Phillips, Siobhan M; Lloyd, Gillian R; Awick, Elizabeth A; McAuley, Edward

2017-09-01

Many breast cancer survivors report cancer and cancer treatment-associated cognitive change. However, very little is known about the relationship between physical activity and subjective memory impairment (SMI) in this population. The purpose of this study is to examine the relationship between physical activity and SMI and longitudinally test a model examining the role of self-efficacy, fatigue and distress as potential mediators. Post-treatment breast cancer survivors (N = 1477) completed measures of physical activity, self-efficacy, distress (depression, concerns about recurrence, perceived stress, anxiety), fatigue and SMI at baseline and 6-month follow-up. A subsample (n = 362) was randomly selected to wear an accelerometer. It was hypothesized that physical activity indirectly influences SMI via exercise self-efficacy, distress and fatigue. Relationships were examined using panel analysis within a covariance modeling framework. The hypothesized model provided a good fit in the full sample (χ 2  = 1462.5, df = 469, p = exercise self-efficacy and reduced distress and fatigue. Higher levels of physical activity, lower levels of fatigue and distress and higher exercise self-efficacy may play an important role in understanding SMI in breast cancer survivors across time. Future research is warranted to replicate and explore these relationships further. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Memory blindness: Altered memory reports lead to distortion in eyewitness memory.

Science.gov (United States)

Cochran, Kevin J; Greenspan, Rachel L; Bogart, Daniel F; Loftus, Elizabeth F

2016-07-01

Choice blindness refers to the finding that people can often be misled about their own self-reported choices. However, little research has investigated the more long-term effects of choice blindness. We examined whether people would detect alterations to their own memory reports, and whether such alterations could influence participants' memories. Participants viewed slideshows depicting crimes, and then either reported their memories for episodic details of the event (Exp. 1) or identified a suspect from a lineup (Exp. 2). Then we exposed participants to manipulated versions of their memory reports, and later tested their memories a second time. The results indicated that the majority of participants failed to detect the misinformation, and that exposing witnesses to misleading versions of their own memory reports caused their memories to change to be consistent with those reports. These experiments have implications for eyewitness memory.

Test-retest reliability of Brazilian version of Memorial Symptom Assessment Scale for assessing symptoms in cancer patients.

Science.gov (United States)

Menezes, Josiane Roberta de; Luvisaro, Bianca Maria Oliveira; Rodrigues, Claudia Fernandes; Muzi, Camila Drumond; Guimarães, Raphael Mendonça

2017-01-01

To assess the test-retest reliability of the Memorial Symptom Assessment Scale translated and culturally adapted into Brazilian Portuguese. The scale was applied in an interview format for 190 patients with various cancers type hospitalized in clinical and surgical sectors of the Instituto Nacional de Câncer José de Alencar Gomes da Silva and reapplied in 58 patients. Data from the test-retest were double typed into a Microsoft Excel spreadsheet and analyzed by the weighted Kappa. The reliability of the scale was satisfactory in test-retest. The weighted Kappa values obtained for each scale item had to be adequate, the largest item was 0.96 and the lowest was 0.69. The Kappa subscale was also evaluated and values were 0.84 for high frequency physic symptoms, 0.81 for low frequency physical symptoms, 0.81 for psychological symptoms, and 0.78 for Global Distress Index. High level of reliability estimated suggests that the process of measurement of Memorial Symptom Assessment Scale aspects was adequate. Avaliar a confiabilidade teste-reteste da versão traduzida e adaptada culturalmente para o português do Brasil do Memorial Symptom Assessment Scale. A escala foi aplicada em forma de entrevista em 190 pacientes com diversos tipos de câncer internados nos setores clínicos e cirúrgicos do Instituto Nacional de Câncer José de Alencar Gomes da Silva e reaplicada em 58 pacientes. Os dados dos testes-retestes foram inseridos num banco de dados por dupla digitação independente em Excel e analisados pelo Kappa ponderado. A confiabilidade da escala mostrou-se satisfatória nos testes-retestes. Os valores do Kappa ponderado obtidos para cada item da escala apresentaram-se adequados, sendo o maior item de 0,96 e o menor de 0,69. Também se avaliou o Kappa das subescalas, sendo de 0,84 para sintomas físicos de alta frequência, de 0,81 para sintomas físicos de baixa frequência, de 0,81 também para sintomas psicológicos, e de 0,78 para Índice Geral de Sofrimento

The Data Release of the Sloan Digital Sky Survey-II Supernova Survey

Science.gov (United States)

Sako, Masao; Bassett, Bruce; Becker, Andrew C.; Brown, Peter J.; Campbell, Heather; Wolf, Rachel; Cinabro, David; D’Andrea, Chris B.; Dawson, Kyle S.; DeJongh, Fritz; Depoy, Darren L.; Dilday, Ben; Doi, Mamoru; Filippenko, Alexei V.; Fischer, John A.; Foley, Ryan J.; Frieman, Joshua A.; Galbany, Lluis; Garnavich, Peter M.; Goobar, Ariel; Gupta, Ravi R.; Hill, Gary J.; Hayden, Brian T.; Hlozek, Renée; Holtzman, Jon A.; Hopp, Ulrich; Jha, Saurabh W.; Kessler, Richard; Kollatschny, Wolfram; Leloudas, Giorgos; Marriner, John; Marshall, Jennifer L.; Miquel, Ramon; Morokuma, Tomoki; Mosher, Jennifer; Nichol, Robert C.; Nordin, Jakob; Olmstead, Matthew D.; Östman, Linda; Prieto, Jose L.; Richmond, Michael; Romani, Roger W.; Sollerman, Jesper; Stritzinger, Max; Schneider, Donald P.; Smith, Mathew; Wheeler, J. Craig; Yasuda, Naoki; Zheng, Chen

2018-06-01

This paper describes the data release of the Sloan Digital Sky Survey-II (SDSS-II) Supernova Survey conducted between 2005 and 2007. Light curves, spectra, classifications, and ancillary data are presented for 10,258 variable and transient sources discovered through repeat ugriz imaging of SDSS Stripe 82, a 300 deg2 area along the celestial equator. This data release is comprised of all transient sources brighter than r ≃ 22.5 mag with no history of variability prior to 2004. Dedicated spectroscopic observations were performed on a subset of 889 transients, as well as spectra for thousands of transient host galaxies using the SDSS-III BOSS spectrographs. Photometric classifications are provided for the candidates with good multi-color light curves that were not observed spectroscopically, using host galaxy redshift information when available. From these observations, 4607 transients are either spectroscopically confirmed, or likely to be, supernovae, making this the largest sample of supernova candidates ever compiled. We present a new method for SN host-galaxy identification and derive host-galaxy properties including stellar masses, star formation rates, and the average stellar population ages from our SDSS multi-band photometry. We derive SALT2 distance moduli for a total of 1364 SN Ia with spectroscopic redshifts as well as photometric redshifts for a further 624 purely photometric SN Ia candidates. Using the spectroscopically confirmed subset of the three-year SDSS-II SN Ia sample and assuming a flat ΛCDM cosmology, we determine Ω M = 0.315 ± 0.093 (statistical error only) and detect a non-zero cosmological constant at 5.7σ.

The Data Release of the Sloan Digital Sky Survey-II Supernova Survey

Energy Technology Data Exchange (ETDEWEB)

Sako, Masao; et al.

2014-01-14

This paper describes the data release of the Sloan Digital Sky Survey-II (SDSS-II) Supernova Survey conducted between 2005 and 2007. Light curves, spectra, classifications, and ancillary data are presented for 10,258 variable and transient sources discovered through repeat ugriz imaging of SDSS Stripe 82, a 300 deg2 area along the celestial equator. This data release is comprised of all transient sources brighter than r~22.5 mag with no history of variability prior to 2004. Dedicated spectroscopic observations were performed on a subset of 889 transients, as well as spectra for thousands of transient host galaxies using the SDSS-III BOSS spectrographs. Photometric classifications are provided for the candidates with good multi-color light curves that were not observed spectroscopically. From these observations, 4607 transients are either spectroscopically confirmed, or likely to be, supernovae, making this the largest sample of supernova candidates ever compiled. We present a new method for SN host-galaxy identification and derive host-galaxy properties including stellar masses, star-formation rates, and the average stellar population ages from our SDSS multi-band photometry. We derive SALT2 distance moduli for a total of 1443 SN Ia with spectroscopic redshifts as well as photometric redshifts for a further 677 purely-photometric SN Ia candidates. Using the spectroscopically confirmed subset of the three-year SDSS-II SN Ia sample and assuming a flat Lambda-CDM cosmology, we determine Omega_M = 0.315 +/- 0.093 (statistical error only) and detect a non-zero cosmological constant at 5.7 sigmas.

Are subjective memory problems related to suggestibility, compliance, false memories, and objective memory performance?

Science.gov (United States)

Van Bergen, Saskia; Jelicic, Marko; Merckelbach, Harald

2009-01-01

The relationship between subjective memory beliefs and suggestibility, compliance, false memories, and objective memory performance was studied in a community sample of young and middle-aged people (N = 142). We hypothesized that people with subjective memory problems would exhibit higher suggestibility and compliance levels and would be more susceptible to false recollections than those who are optimistic about their memory. In addition, we expected a discrepancy between subjective memory judgments and objective memory performance. We found that subjective memory judgments correlated significantly with compliance, with more negative memory judgments accompanying higher levels of compliance. Contrary to our expectation, subjective memory problems did not correlate with suggestibility or false recollections. Furthermore, participants were accurate in estimating their objective memory performance.

TOPOLOGY OF LUMINOUS RED GALAXIES FROM THE SLOAN DIGITAL SKY SURVEY

International Nuclear Information System (INIS)

Choi, Yun-Young; Kim, Juhan; Rossi, Graziano; Kim, Sungsoo S.; Lee, Jeong-Eun

2013-01-01

We present measurements of the genus topology of luminous red galaxies (LRGs) from the Sloan Digital Sky Survey (SDSS) Data Release 7 catalog, with unprecedented statistical significance. To estimate the uncertainties in the measured genus, we construct 81 mock SDSS LRG surveys along the past light cone from Horizon Run 3, one of the largest N-body simulations to date, which evolved 7210 3 particles in a 10,815 h –1  Mpc box. After carefully modeling and removing all known systematic effects due to finite pixel size, survey boundary, radial and angular selection functions, shot noise, and galaxy biasing, we find that the observed genus amplitude reaches 272 at a 22 h –1  Mpc smoothing scale, with an uncertainty of 4.2%; the estimated error fully incorporates cosmic variance. This is the most accurate constraint on the genus amplitude to date and significantly improves on our previous results. In particular, the shape of the genus curve agrees very well with the mean topology of the SDSS LRG mock surveys in a Λ cold dark matter universe. However, comparison with simulations also shows small deviations of the observed genus curve from the theoretical expectation for Gaussian initial conditions. While these discrepancies are mainly driven by known systematic effects such as shot noise and redshift-space distortions, they do contain important cosmological information on the physical effects connected with galaxy formation, gravitational evolution, and primordial non-Gaussianity. We address the key role played by systematics on the genus curve and show how to accurately correct for their effects to recover the topology of the underlying matter. A future work will provide an interpretation of these deviations in the context of the local model of non-Gaussianity

The Sloan Digital Sky Survey Quasar Catalog. 4. Fifth Data Release

Energy Technology Data Exchange (ETDEWEB)

Schneider, Donald P.; Hall, Patrick B.; Richards, Gordon T.; Strauss, Michael A.; Vanden Berk, Daniel E.; Anderson, Scott F.; Brandt, W.N.; Fan, Xiao-Hui; Jester,; Gray, Jim; Gunn, James E.; /Penn State U., Astron. Astrophys. /York U., Canada /Johns Hopkins U. /Princeton U. Observ. /Washington U., Seattle, Astron. Dept. /Arizona

2007-04-01

We present the fourth edition of the Sloan Digital Sky Survey (SDSS) Quasar Catalog. The catalog contains 77,429 objects; this is an increase of over 30,000 entries since the previous edition. The catalog consists of the objects in the SDSS Fifth Data Release that have luminosities larger than M{sub i} = -22.0 (in a cosmology with H{sub 0} = 70 km s{sup -1} Mpc{sup -1}, {Omega}{sub M} = 0.3, and {Omega}{sub {Lambda}} = 0.7), have at least one emission line with FWHM larger than 1000 km s{sup -1} or have interesting/complex absorption features, are fainter than i {approx} 15.0, and have highly reliable redshifts. The area covered by the catalog is {approx} 5740 deg{sup 2}. The quasar redshifts range from 0.08 to 5.41, with a median value of 1.48; the catalog includes 891 quasars at redshifts greater than four, of which 36 are at redshifts greater than five. Approximately half of the catalog quasars have i < 19; nearly all have i < 21. For each object the catalog presents positions accurate to better than 0.2-minutes rms per coordinate, five-band (ugriz) CCD-based photometry with typical accuracy of 0.03 mag, and information on the morphology and selection method. The catalog also contains basic radio, near-infrared, and X-ray emission properties of the quasars, when available, from other large-area surveys. The calibrated digital spectra cover the wavelength region 3800-9200 {angstrom} at a spectral resolution of {approx_equal} 2000; the spectra can be retrieved from the public database using the information provided in the catalog. The average SDSS colors of quasars as a function of redshift, derived from the catalog entries, are presented in tabular form. Approximately 96% of the objects in the catalog were discovered by the SDSS.

SDSS J2222+2745: A GRAVITATIONALLY LENSED SEXTUPLE QUASAR WITH A MAXIMUM IMAGE SEPARATION OF 15.''1 DISCOVERED IN THE SLOAN GIANT ARCS SURVEY

International Nuclear Information System (INIS)

Dahle, H.; Groeneboom, N.; Gladders, M. D.; Abramson, L. E.; Sharon, K.; Bayliss, M. B.; Wuyts, E.; Koester, B. P.; Brinckmann, T. E.; Kristensen, M. T.; Lindholmer, M. O.; Nielsen, A.; Krogager, J.-K.; Fynbo, J. P. U.

2013-01-01

We report the discovery of a unique gravitational lens system, SDSS J2222+2745, producing five spectroscopically confirmed images of a z s = 2.82 quasar lensed by a foreground galaxy cluster at z l = 0.49. We also present photometric and spectroscopic evidence for a sixth lensed image of the same quasar. The maximum separation between the quasar images is 15.''1. Both the large image separations and the high image multiplicity are in themselves rare among known lensed quasars, and observing the combination of these two factors is an exceptionally unlikely occurrence in present data sets. This is only the third known case of a quasar lensed by a cluster, and the only one with six images. The lens system was discovered in the course of the Sloan Giant Arcs Survey, in which we identify candidate lenses in the Sloan Digital Sky Survey and target these for follow-up and verification with the 2.56 m Nordic Optical Telescope. Multi-band photometry obtained over multiple epochs from 2011 September to 2012 September reveals significant variability at the ∼10%-30% level in some of the quasar images, indicating that measurements of the relative time delay between quasar images will be feasible. In this lens system, we also identify a bright (g = 21.5) giant arc corresponding to a strongly lensed background galaxy at z s = 2.30. We fit parametric models of the lens system, constrained by the redshift and positions of the quasar images and the redshift and position of the giant arc. The predicted time delays between different pairs of quasar images range from ∼100 days to ∼6 yr

A comparison of three types of autobiographical memories in old-old age: first memories, pivotal memories and traumatic memories.

Science.gov (United States)

Cohen-Mansfield, Jiska; Shmotkin, Dov; Eyal, Nitza; Reichental, Yael; Hazan, Haim

2010-01-01

Autobiographical memory enables us to construct a personal narrative through which we identify ourselves. Especially important are memories of formative events. This study describes autobiographical memories of people who have reached old-old age (85 years and above), studying 3 types of memories of particular impact on identity and adaptation: first memories, pivotal memories and traumatic memories. In this paper, we examine the content, characteristic themes and environments, and structural characteristics of each of the 3 types of memory. The participants were 26 persons from a larger longitudinal study with an average age of 91 years; half were men and the other half women. The study integrated qualitative and quantitative tools. An open-ended questionnaire included questions about the participants' life story as well as questions about the 3 types of memories. The responses were rated by 3 independent judges on dimensions of central themes and structural characteristics. First memories had a more positive emotional tone, more references to characters from the participant's social circle, a stronger sense of group belonging, and a more narrative style than the other types of memories. Pivotal and traumatic memories were described as more personal than first memories. The 3 types of memories reflect different stages in life development, which together form a sense of identity. They present experiences from the past on select themes, which may assist in the complex task of coping with the difficulties and limitations that advanced old age presents. Future research should examine the functional role of those memories and whether they enable the old-old to support selfhood in the challenging period of last changes and losses. Copyright © 2010 S. Karger AG, Basel.

Temporal knowledge and autobiographical memory: an evolutionary perspective

OpenAIRE

Skowronski, John J.; Sedikides, Constantine

2007-01-01

Section I: Philosophical issues 1. Evolutionary pyschology in the round , Robin Dunbar & Louise Barrett 2. The power of culture , Henry Plotkin 3. Evolution and psychology in philosophical perspective , Matteo Mameli 4. Niche construction, human behavioural ecology and evolutionary psychology , Kevin N Laland 5. Group level evolutionary processes , David Sloan Wilson Section II: The comparative Approach 6. Homologizing the mind , Drew Rendall, Hugh Nottman & John ...

A SYSTEMATIC SEARCH FOR MASSIVE BLACK HOLE BINARIES IN THE SLOAN DIGITAL SKY SURVEY SPECTROSCOPIC SAMPLE

International Nuclear Information System (INIS)

Tsalmantza, P.; Decarli, R.; Hogg, David W.; Dotti, M.

2011-01-01

We present the results of a systematic search for massive black hole binaries in the Sloan Digital Sky Survey (SDSS) spectroscopic database. We focus on bound binaries, under the assumption that one of the black holes is active. In this framework, the broad lines associated with the accreting black hole are expected to show systematic velocity shifts with respect to the narrow lines, which trace the rest frame of the galaxy. For a sample of 54,586 quasars and 3929 galaxies at redshifts 0.1 < z < 1.5, we brute-force model each spectrum as a mixture of two quasars at two different redshifts. The spectral model is a data-driven dimensionality reduction of the SDSS quasar spectra based on a matrix factorization. We identified 32 objects with peculiar spectra. Nine of them can be interpreted as black hole binaries. This doubles the number of known black hole binary candidates. We also report on the discovery of a new class of extreme double-peaked emitters with exceptionally broad and faint Balmer lines. For all the interesting sources, we present detailed analysis of the spectra and discuss possible interpretations.

A RADIO SEARCH FOR PULSAR COMPANIONS TO SLOAN DIGITAL SKY SURVEY LOW-MASS WHITE DWARFS

International Nuclear Information System (INIS)

Agueeros, Marcel A.; Camilo, Fernando; Silvestri, Nicole M.; Anderson, Scott F.; Kleinman, S. J.; Liebert, James W.

2009-01-01

We have conducted a search for pulsar companions to 15 low-mass white dwarfs (LMWDs; M sun ) at 820 MHz with the NRAO Green Bank Telescope (GBT). These LMWDs were spectroscopically identified in the Sloan Digital Sky Survey (SDSS), and do not show the photometric excess or spectroscopic signature associated with a companion in their discovery data. However, LMWDs are believed to evolve in binary systems and to have either a more massive white dwarf (WD) or a neutron star (NS) as a companion. Indeed, evolutionary models of low-mass X-ray binaries, the precursors of millisecond pulsars (MSPs), produce significant numbers of LMWDs, suggesting that the SDSS LMWDs may have NS companions. No convincing pulsar signal is detected in our data. This is consistent with the findings of van Leeuwen et al., who conducted a GBT search for radio pulsations at 340 MHz from unseen companions to eight SDSS WDs (five are still considered LMWDs; the three others are now classified as 'ordinary' WDs). We discuss the constraints our nondetections place on the probability P MSP that the companion to a given LMWD is a radio pulsar in the context of the luminosity and acceleration limits of our search; we find that P MSP +4 -2 %.

Aging memories: differential decay of episodic memory components.

Science.gov (United States)

Talamini, Lucia M; Gorree, Eva

2012-05-17

Some memories about events can persist for decades, even a lifetime. However, recent memories incorporate rich sensory information, including knowledge on the spatial and temporal ordering of event features, while old memories typically lack this "filmic" quality. We suggest that this apparent change in the nature of memories may reflect a preferential loss of hippocampus-dependent, configurational information over more cortically based memory components, including memory for individual objects. The current study systematically tests this hypothesis, using a new paradigm that allows the contemporaneous assessment of memory for objects, object pairings, and object-position conjunctions. Retention of each memory component was tested, at multiple intervals, up to 3 mo following encoding. The three memory subtasks adopted the same retrieval paradigm and were matched for initial difficulty. Results show differential decay of the tested episodic memory components, whereby memory for configurational aspects of a scene (objects' co-occurrence and object position) decays faster than memory for featured objects. Interestingly, memory requiring a visually detailed object representation decays at a similar rate as global object recognition, arguing against interpretations based on task difficulty and against the notion that (visual) detail is forgotten preferentially. These findings show that memories undergo qualitative changes as they age. More specifically, event memories become less configurational over time, preferentially losing some of the higher order associations that are dependent on the hippocampus for initial fast encoding. Implications for theories of long-term memory are discussed.

THE FIFTH DATA RELEASE SLOAN DIGITAL SKY SURVEY/XMM-NEWTON QUASAR SURVEY

International Nuclear Information System (INIS)

Young, M.; Elvis, M.; Risaliti, G.

2009-01-01

We present a catalog of 792 Fifth Data Release Sloan Digital Sky Survey quasars with optical spectra that have been observed serendipitously in the X-rays with the XMM-Newton. These quasars cover a redshift range of z = 0.11-5.41 and a magnitude range of i = 15.3-20.7. Substantial numbers of radio-loud (70) and broad absorption line (51) quasars exist within this sample. Significant X-ray detections at ≥2σ account for 87% of the sample (685 quasars), and 473 quasars are detected at ≥6σ, sufficient to allow X-ray spectral fits. For detected sources, ∼60% have X-ray fluxes between F 2-10keV = (1-10) x10 -14 erg cm -2 s -1 . We fit a single power law, a fixed power law with intrinsic absorption left free to vary, and an absorbed power-law model to all quasars with X-ray signal-to-noise ratio ≥ 6, resulting in a weighted mean photon index Γ = 1.91 ± 0.08, with an intrinsic dispersion σ Γ = 0.38. For the 55 sources (11.6%) that prefer intrinsic absorption, we find a weighted mean N H = 1.5 ± 0.3 x 10 21 cm -2 . We find that Γ correlates significantly with optical color, Δ(g - i), the optical-to-X-ray spectral index (α ox ), and the X-ray luminosity. While the first two correlations can be explained as artifacts of undetected intrinsic absorption, the correlation between Γ and X-ray luminosity appears to be a real physical correlation, indicating a pivot in the X-ray slope.

A SEARCH FOR DISK-GALAXY LENSES IN THE SLOAN DIGITAL SKY SURVEY

International Nuclear Information System (INIS)

Feron, Chloe; Hjorth, Jens; Samsing, Johan; McKean, John P.

2009-01-01

We present the first automated spectroscopic search for disk-galaxy lenses, using the Sloan Digital Sky Survey (SDSS) database. We follow up eight gravitational lens candidates, selected among a sample of ∼40,000 candidate massive disk galaxies, using a combination of ground-based imaging and long-slit spectroscopy. We confirm two gravitational lens systems: one probable disk galaxy and one probable S0 galaxy. The remaining systems are four promising disk-galaxy lens candidates, as well as two probable gravitational lenses whose lens galaxy might be an S0 galaxy. The redshifts of the lenses are z lens ∼ 0.1. The redshift range of the background sources is z source ∼ 0.3-0.7. The systems presented here are (confirmed or candidate) galaxy-galaxy lensing systems, that is, systems where the multiple images are faint and extended, allowing an accurate determination of the lens galaxy mass and light distributions without contamination from the background galaxy. Moreover, the low redshift of the (confirmed or candidates) lens galaxies is favorable for measuring rotation points to complement the lensing study. We estimate the rest-frame total mass-to-light ratio within the Einstein radius for the two confirmed lenses: we find M tot /L I = 5.4 ± 1.5 within 3.9 ± 0.9 kpc for SDSS J081230.30+543650.9 and M tot /L I = 1.5 ± 0.9 within 1.4 ± 0.8 kpc for SDSS J145543.55+530441.2 (all in solar units). Hubble Space Telescope or adaptive optics imaging is needed to further study the systems.

Exploring memory hierarchy design with emerging memory technologies

CERN Document Server

Sun, Guangyu

2014-01-01

This book equips readers with tools for computer architecture of high performance, low power, and high reliability memory hierarchy in computer systems based on emerging memory technologies, such as STTRAM, PCM, FBDRAM, etc.  The techniques described offer advantages of high density, near-zero static power, and immunity to soft errors, which have the potential of overcoming the “memory wall.”  The authors discuss memory design from various perspectives: emerging memory technologies are employed in the memory hierarchy with novel architecture modification;  hybrid memory structure is introduced to leverage advantages from multiple memory technologies; an analytical model named “Moguls” is introduced to explore quantitatively the optimization design of a memory hierarchy; finally, the vulnerability of the CMPs to radiation-based soft errors is improved by replacing different levels of on-chip memory with STT-RAMs.   ·         Provides a holistic study of using emerging memory technologies i...

The anticancer estrogen receptor antagonist tamoxifen impairs consolidation of inhibitory avoidance memory through estrogen receptor alpha.

Science.gov (United States)

Lichtenfels, Martina; Dornelles, Arethuza da Silva; Petry, Fernanda Dos Santos; Blank, Martina; de Farias, Caroline Brunetto; Roesler, Rafael; Schwartsmann, Gilberto

2017-11-01

Over two-thirds of women with breast cancer have positive tumors for hormone receptors, and these patients undergo treatment with endocrine therapy, tamoxifen being the most widely used agent. Despite being very effective in breast cancer treatment, tamoxifen is associated with side effects that include cognitive impairments. However, the specific aspects and mechanisms underlying these impairments remain to be characterized. Here, we have investigated the effects of tamoxifen and interaction with estrogen receptors on formation of memory for inhibitory avoidance conditioning in female rats. In the first experiment, Wistar female rats received a single oral dose of tamoxifen (1, 3, or 10 mg/kg) or saline by gavage immediately after training and were tested for memory consolidation 24 h after training. In the second experiment, rats received a single dose of 1 mg/kg tamoxifen or saline by gavage 3 h after training and were tested 24 h after training for memory consolidation. In the third experiment, rats received a subcutaneous injection with estrogen receptor α agonist or estrogen receptor beta agonist 30 min before the training. After training, rats received a single oral dose of tamoxifen 1 mg/kg or saline and were tested 24 h after training. In the fourth experiment, rats were trained and tested 24 h later. Immediately after test, rats received a single dose of tamoxifen (1 mg/kg) or saline by gavage and were given four additional daily test trials followed by a re-instatement. Tamoxifen at 1 mg/kg impaired memory consolidation when given immediately after training and the estrogen receptor alpha agonist improved the tamoxifen-related memory impairment. Moreover, tamoxifen impairs memory consolidation of the test. These findings indicate that estrogen receptors regulate the early phase of memory consolidation and the effects of tamoxifen on memory consolidation.

The Sloan Digital Sky Survey Quasar Lens Search. VI. Constraints on Dark Energy and the Evolution of Massive Galaxies

Energy Technology Data Exchange (ETDEWEB)

Oguri, Masamune [Univ. of Tokyo (Japan); et al.

2012-05-01

We present a statistical analysis of the final lens sample from the Sloan Digital Sky Survey Quasar Lens Search (SQLS). The number distribution of a complete subsample of 19 lensed quasars selected from 50,836 source quasars is compared with theoretical expectations, with particular attention to the selection function. Assuming that the velocity function of galaxies does not evolve with redshift, the SQLS sample constrains the cosmological constant to \\Omega_\\Lambda=0.79^{+0.06}_{-0.07}(stat.)^{+0.06}_{-0.06}(syst.) for a flat universe. The dark energy equation of state is found to be consistent with w=-1 when the SQLS is combined with constraints from baryon acoustic oscillation (BAO) measurements or results from the Wilkinson Microwave Anisotropy Probe (WMAP). We also obtain simultaneous constraints on cosmological parameters and redshift evolution of the galaxy velocity function, finding no evidence for redshift evolution at z<1 in any combinations of constraints. For instance, number density evolution quantified as \

The role of cytokines in T-cell memory in health and disease.

Science.gov (United States)

Raeber, Miro E; Zurbuchen, Yves; Impellizzieri, Daniela; Boyman, Onur

2018-05-01

Upon stimulation with their cognate antigen, naive T cells undergo proliferation and differentiation into effector cells, followed by apoptosis or survival as precursors of long-lived memory cells. These phases of a T-cell response and the ensuing maintenance of memory T cells are shaped by cytokines, most notably interleukin-2 (IL-2), IL-7, and IL-15 that share the common γ chain (γ c ) cytokine receptor. Steady-state production of IL-7 and IL-15 is necessary for background proliferation and homeostatic survival of CD4 + and CD8 + memory T cells. During immune responses, augmented levels of IL-2, IL-15, IL-21, IL-12, IL-18, and type-I interferons determine the memory potential of antigen-specific effector CD8 + cells, while increased IL-2 and IL-15 cause bystander proliferation of heterologous CD4 + and CD8 + memory T cells. Limiting availability of γ c cytokines, reduction in regulatory T cells or IL-10, and persistence of inflammation or cognate antigen can result in memory T cells, which fail to become cytokine-dependent long-lived cells. Conversely, increased IL-7 and IL-15 can expand memory T cells, including pathogenic tissue-resident memory T cells, as seen in lymphopenia and certain chronic-inflammatory disorders and malignancies. These abovementioned factors impact immunotherapy and vaccines directed at memory T cells in cancer and chronic infection. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

MEMORY MODULATION

Science.gov (United States)

Roozendaal, Benno; McGaugh, James L.

2011-01-01

Our memories are not all created equally strong: Some experiences are well remembered while others are remembered poorly, if at all. Research on memory modulation investigates the neurobiological processes and systems that contribute to such differences in the strength of our memories. Extensive evidence from both animal and human research indicates that emotionally significant experiences activate hormonal and brain systems that regulate the consolidation of newly acquired memories. These effects are integrated through noradrenergic activation of the basolateral amygdala which regulates memory consolidation via interactions with many other brain regions involved in consolidating memories of recent experiences. Modulatory systems not only influence neurobiological processes underlying the consolidation of new information, but also affect other mnemonic processes, including memory extinction, memory recall and working memory. In contrast to their enhancing effects on consolidation, adrenal stress hormones impair memory retrieval and working memory. Such effects, as with memory consolidation, require noradrenergic activation of the basolateral amygdala and interactions with other brain regions. PMID:22122145

Memory architecture

NARCIS (Netherlands)

2012-01-01

A memory architecture is presented. The memory architecture comprises a first memory and a second memory. The first memory has at least a bank with a first width addressable by a single address. The second memory has a plurality of banks of a second width, said banks being addressable by components

Detailed sensory memory, sloppy working memory

Directory of Open Access Journals (Sweden)

Ilja G Sligte

2010-10-01

Full Text Available Visual short-term memory (VSTM enables us to actively maintain information in mind for a brief period of time after stimulus disappearance. According to recent studies, VSTM consists of three stages - iconic memory, fragile VSTM, and visual working memory - with increasingly stricter capacity limits and progressively longer lifetimes. Still, the resolution (or amount of visual detail of each VSTM stage has remained unexplored and we test this in the present study. We presented people with a change detection task that measures the capacity of all three forms of VSTM, and we added an identification display after each change trial that required people to identify the pre-change object. Accurate change detection plus pre-change identification requires subjects to have a high-resolution representation of the pre-change object, whereas change detection or identification only can be based on the hunch that something has changed, without exactly knowing what was presented before. We observed that people maintained 6.1 objects in iconic memory, 4.6 objects in fragile VSTM and 2.1 objects in visual working memory. Moreover, when people detected the change, they could also identify the pre-change object on 88 percent of the iconic memory trials, on 71 percent of the fragile VSTM trials and merely on 53 percent of the visual working memory trials. This suggests that people maintain many high-resolution representations in iconic memory and fragile VSTM, but only one high-resolution object representation in visual working memory.

Detailed sensory memory, sloppy working memory.

Science.gov (United States)

Sligte, Ilja G; Vandenbroucke, Annelinde R E; Scholte, H Steven; Lamme, Victor A F

2010-01-01

Visual short-term memory (VSTM) enables us to actively maintain information in mind for a brief period of time after stimulus disappearance. According to recent studies, VSTM consists of three stages - iconic memory, fragile VSTM, and visual working memory - with increasingly stricter capacity limits and progressively longer lifetimes. Still, the resolution (or amount of visual detail) of each VSTM stage has remained unexplored and we test this in the present study. We presented people with a change detection task that measures the capacity of all three forms of VSTM, and we added an identification display after each change trial that required people to identify the "pre-change" object. Accurate change detection plus pre-change identification requires subjects to have a high-resolution representation of the "pre-change" object, whereas change detection or identification only can be based on the hunch that something has changed, without exactly knowing what was presented before. We observed that people maintained 6.1 objects in iconic memory, 4.6 objects in fragile VSTM, and 2.1 objects in visual working memory. Moreover, when people detected the change, they could also identify the pre-change object on 88% of the iconic memory trials, on 71% of the fragile VSTM trials and merely on 53% of the visual working memory trials. This suggests that people maintain many high-resolution representations in iconic memory and fragile VSTM, but only one high-resolution object representation in visual working memory.

A Milestone in Cancer Research and Treatment in India

Science.gov (United States)

Tata Memorial Center is celebrating 75 years of leadership service towards cancer control and research in India. In honor of this anniversary, TMC is hosting A Conference of New Ideas in Cancer – Challenging Dogmas on February 26-28th, 2016 as part of its platinum jubilee events. CGH Director, Dr. Ted Trimble, will give a plenary talk: "Thinking Outside the Box in Cancer Research - Perspectives from the US NCI” in the session titled: Future of Cancer Research: US and European perspectives.

The Sloan Digital Sky Survey Science Archive: Migrating a Multi-Terabyte Astronomical Archive from Object to Relational DBMS

CERN Document Server

Thakar, A R; Kunszt, Peter Z; Gray, J; Thakar, Aniruddha R.; Szalay, Alexander S.; Kunszt, Peter Z.; Gray, Jim

2004-01-01

The Sloan Digital Sky Survey Science Archive is the first in a series of multi-Terabyte digital archives in Astronomy and other data-intensive sciences. To facilitate data mining in the SDSS archive, we adapted a commercial database engine and built specialized tools on top of it. Originally we chose an object-oriented database management system due to its data organization capabilities, platform independence, query performance and conceptual fit to the data. However, after using the object database for the first couple of years of the project, it soon began to fall short in terms of its query support and data mining performance. This was as much due to the inability of the database vendor to respond our demands for features and bug fixes as it was due to their failure to keep up with the rapid improvements in hardware performance, particularly faster RAID disk systems. In the end, we were forced to abandon the object database and migrate our data to a relational database. We describe below the technical issu...

Memory Function Before and After Whole Brain Radiotherapy in Patients With and Without Brain Metastases

International Nuclear Information System (INIS)

Welzel, Grit; Fleckenstein, Katharina; Schaefer, Joerg; Hermann, Brigitte; Kraus-Tiefenbacher, Uta; Mai, Sabine K.; Wenz, Frederik

2008-01-01

Purpose: To prospectively compare the effect of prophylactic and therapeutic whole brain radiotherapy (WBRT) on memory function in patients with and without brain metastases. Methods and Materials: Adult patients with and without brain metastases (n = 44) were prospectively evaluated with serial cognitive testing, before RT (T0), after starting RT (T1), at the end of RT (T2), and 6-8 weeks (T3) after RT completion. Data were obtained from small-cell lung cancer patients treated with prophylactic cranial irradiation, patients with brain metastases treated with therapeutic cranial irradiation (TCI), and breast cancer patients treated with RT to the breast. Results: Before therapy, prophylactic cranial irradiation patients performed worse than TCI patients or than controls on most test scores. During and after WBRT, verbal memory function was influenced by pretreatment cognitive status (p < 0.001) and to a lesser extent by WBRT. Acute (T1) radiation effects on verbal memory function were only observed in TCI patients (p = 0.031). Subacute (T3) radiation effects on verbal memory function were observed in both TCI and prophylactic cranial irradiation patients (p = 0.006). These effects were more pronounced in patients with above-average performance at baseline. Visual memory and attention were not influenced by WBRT. Conclusions: The results of our study have shown that WBRT causes cognitive dysfunction immediately after the beginning of RT in patients with brain metastases only. At 6-8 weeks after the end of WBRT, cognitive dysfunction was seen in patients with and without brain metastases. Because cognitive dysfunction after WBRT is restricted to verbal memory, patients should not avoid WBRT because of a fear of neurocognitive side effects

Detailed sensory memory, sloppy working memory

NARCIS (Netherlands)

Sligte, I.G.; Vandenbroucke, A.R.E.; Scholte, H.S.; Lamme, V.A.F.

2010-01-01

Visual short-term memory (VSTM) enables us to actively maintain information in mind for a brief period of time after stimulus disappearance. According to recent studies, VSTM consists of three stages - iconic memory, fragile VSTM, and visual working memory - with increasingly stricter capacity

A real-time multichannel memory controller and optimal mapping of memory clients to memory channels

NARCIS (Netherlands)

Gomony, M.D.; Akesson, K.B.; Goossens, K.G.W.

2015-01-01

Ever-increasing demands for main memory bandwidth and memory speed/power tradeoff led to the introduction of memories with multiple memory channels, such as Wide IO DRAM. Efficient utilization of a multichannel memory as a shared resource in multiprocessor real-time systems depends on mapping of the

THE SLOAN DIGITAL SKY SURVEY REVERBERATION MAPPING PROJECT: TECHNICAL OVERVIEW

Energy Technology Data Exchange (ETDEWEB)

Shen, Yue [Carnegie Observatories, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); Brandt, W. N. [Department of Astronomy and Astrophysics, The Pennsylvania State University, University Park, PA 16802 (United States); Dawson, Kyle S. [Department of Physics and Astronomy, University of Utah, 115 South 1400 East, Salt Lake City, UT 84112 (United States); Hall, Patrick B. [Department of Physics and Astronomy, York University, Toronto, ON M3J 1P3 (Canada); McGreer, Ian D.; Fan, Xiaohui [Steward Observatory, The University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721-0065 (United States); Anderson, Scott F. [Astronomy Department, University of Washington, Box 351580, Seattle, WA 98195 (United States); Chen, Yuguang [Department of Astronomy, School of Physics, Peking University, Beijing 100871 (China); Denney, Kelly D. [Department of Astronomy, The Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States); Eftekharzadeh, Sarah [Department of Physics and Astronomy, University of Wyoming, 1000 East University Avenue, Laramie, WY 82071 (United States); Gao, Yang [Department of Engineering Physics and Center for Astrophysics, Tsinghua University, Beijing 100084 (China); Green, Paul J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Greene, Jenny E. [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Ho, Luis C. [Kavli Institute for Astronomy and Astrophysics, Peking University, Beijing 100871 (China); Horne, Keith [SUPA Physics/Astronomy, University of St. Andrews, St. Andrews KY16 9SS (United Kingdom); Jiang, Linhua [School of Earth and Space Exploration, Arizona State University, Tempe, AZ 85287-1504 (United States); Kelly, Brandon C. [Department of Physics, Broida Hall, University of California, Santa Barbara, CA 93107 (United States); and others

2015-01-01

The Sloan Digital Sky Survey Reverberation Mapping (SDSS-RM) project is a dedicated multi-object RM experiment that has spectroscopically monitored a sample of 849 broad-line quasars in a single 7 deg{sup 2} field with the SDSS-III Baryon Oscillation Spectroscopic Survey spectrograph. The RM quasar sample is flux-limited to i {sub psf} = 21.7 mag, and covers a redshift range of 0.1 < z < 4.5 without any other cuts on quasar properties. Optical spectroscopy was performed during 2014 January-July dark/gray time, with an average cadence of ∼4 days, totaling more than 30 epochs. Supporting photometric monitoring in the g and i bands was conducted at multiple facilities including the Canada-France-Hawaii Telescope (CFHT) and the Steward Observatory Bok telescope in 2014, with a cadence of ∼2 days and covering all lunar phases. The RM field (R.A., decl. = 14:14:49.00, +53:05:00.0) lies within the CFHT-LS W3 field, and coincides with the Pan-STARRS 1 (PS1) Medium Deep Field MD07, with three prior years of multi-band PS1 light curves. The SDSS-RM six month baseline program aims to detect time lags between the quasar continuum and broad line region (BLR) variability on timescales of up to several months (in the observed frame) for ∼10% of the sample, and to anchor the time baseline for continued monitoring in the future to detect lags on longer timescales and at higher redshift. SDSS-RM is the first major program to systematically explore the potential of RM for broad-line quasars at z > 0.3, and will investigate the prospects of RM with all major broad lines covered in optical spectroscopy. SDSS-RM will provide guidance on future multi-object RM campaigns on larger scales, and is aiming to deliver more than tens of BLR lag detections for a homogeneous sample of quasars. We describe the motivation, design, and implementation of this program, and outline the science impact expected from the resulting data for RM and general quasar science.

THE SLOAN DIGITAL SKY SURVEY REVERBERATION MAPPING PROJECT: TECHNICAL OVERVIEW

International Nuclear Information System (INIS)

Shen, Yue; Brandt, W. N.; Dawson, Kyle S.; Hall, Patrick B.; McGreer, Ian D.; Fan, Xiaohui; Anderson, Scott F.; Chen, Yuguang; Denney, Kelly D.; Eftekharzadeh, Sarah; Gao, Yang; Green, Paul J.; Greene, Jenny E.; Ho, Luis C.; Horne, Keith; Jiang, Linhua; Kelly, Brandon C.

2015-01-01

The Sloan Digital Sky Survey Reverberation Mapping (SDSS-RM) project is a dedicated multi-object RM experiment that has spectroscopically monitored a sample of 849 broad-line quasars in a single 7 deg 2 field with the SDSS-III Baryon Oscillation Spectroscopic Survey spectrograph. The RM quasar sample is flux-limited to i psf = 21.7 mag, and covers a redshift range of 0.1 < z < 4.5 without any other cuts on quasar properties. Optical spectroscopy was performed during 2014 January-July dark/gray time, with an average cadence of ∼4 days, totaling more than 30 epochs. Supporting photometric monitoring in the g and i bands was conducted at multiple facilities including the Canada-France-Hawaii Telescope (CFHT) and the Steward Observatory Bok telescope in 2014, with a cadence of ∼2 days and covering all lunar phases. The RM field (R.A., decl. = 14:14:49.00, +53:05:00.0) lies within the CFHT-LS W3 field, and coincides with the Pan-STARRS 1 (PS1) Medium Deep Field MD07, with three prior years of multi-band PS1 light curves. The SDSS-RM six month baseline program aims to detect time lags between the quasar continuum and broad line region (BLR) variability on timescales of up to several months (in the observed frame) for ∼10% of the sample, and to anchor the time baseline for continued monitoring in the future to detect lags on longer timescales and at higher redshift. SDSS-RM is the first major program to systematically explore the potential of RM for broad-line quasars at z > 0.3, and will investigate the prospects of RM with all major broad lines covered in optical spectroscopy. SDSS-RM will provide guidance on future multi-object RM campaigns on larger scales, and is aiming to deliver more than tens of BLR lag detections for a homogeneous sample of quasars. We describe the motivation, design, and implementation of this program, and outline the science impact expected from the resulting data for RM and general quasar science

The sloan digital sky Survey-II supernova survey: search algorithm and follow-up observations

Energy Technology Data Exchange (ETDEWEB)

Sako, Masao [Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA 19104 (United States); Bassett, Bruce [Department of Mathematics and Applied Mathematics, University of Cape Town, Rondebosch 7701 (South Africa); Becker, Andrew; Hogan, Craig J. [Department of Astronomy, University of Washington, Box 351580, Seattle, WA 98195 (United States); Cinabro, David [Department of Physics, Wayne State University, Detroit, MI 48202 (United States); DeJongh, Fritz; Frieman, Joshua A.; Marriner, John; Miknaitis, Gajus [Center for Particle Astrophysics, Fermi National Accelerator Laboratory, P.O. Box 500, Batavia, IL 60510 (United States); Depoy, D. L.; Prieto, Jose Luis [Department of Astronomy, Ohio State University, 140 West 18th Avenue, Columbus, OH 43210-1173 (United States); Dilday, Ben; Kessler, Richard [Kavli Institute for Cosmological Physics, The University of Chicago, 5640 South Ellis Avenue Chicago, IL 60637 (United States); Doi, Mamoru [Institute of Astronomy, Graduate School of Science, University of Tokyo 2-21-1, Osawa, Mitaka, Tokyo 181-0015 (Japan); Garnavich, Peter M. [University of Notre Dame, 225 Nieuwland Science, Notre Dame, IN 46556-5670 (United States); Holtzman, Jon [Department of Astronomy, MSC 4500, New Mexico State University, P.O. Box 30001, Las Cruces, NM 88003 (United States); Jha, Saurabh [Kavli Institute for Particle Astrophysics and Cosmology, Stanford University, P.O. Box 20450, MS29, Stanford, CA 94309 (United States); Konishi, Kohki [Institute for Cosmic Ray Research, University of Tokyo, 5-1-5, Kashiwanoha, Kashiwa, Chiba, 277-8582 (Japan); Lampeitl, Hubert [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Nichol, Robert C. [Institute of Cosmology and Gravitation, Mercantile House, Hampshire Terrace, University of Portsmouth, Portsmouth PO1 2EG (United Kingdom); and others

2008-01-01

The Sloan Digital Sky Survey-II Supernova Survey has identified a large number of new transient sources in a 300 deg{sup 2} region along the celestial equator during its first two seasons of a three-season campaign. Multi-band (ugriz) light curves were measured for most of the sources, which include solar system objects, galactic variable stars, active galactic nuclei, supernovae (SNe), and other astronomical transients. The imaging survey is augmented by an extensive spectroscopic follow-up program to identify SNe, measure their redshifts, and study the physical conditions of the explosions and their environment through spectroscopic diagnostics. During the survey, light curves are rapidly evaluated to provide an initial photometric type of the SNe, and a selected sample of sources are targeted for spectroscopic observations. In the first two seasons, 476 sources were selected for spectroscopic observations, of which 403 were identified as SNe. For the type Ia SNe, the main driver for the survey, our photometric typing and targeting efficiency is 90%. Only 6% of the photometric SN Ia candidates were spectroscopically classified as non-SN Ia instead, and the remaining 4% resulted in low signal-to-noise, unclassified spectra. This paper describes the search algorithm and the software, and the real-time processing of the SDSS imaging data. We also present the details of the supernova candidate selection procedures and strategies for follow-up spectroscopic and imaging observations of the discovered sources.

The Sloan Digital Sky Survey-II Supernova Survey:Search Algorithm and Follow-up Observations

Energy Technology Data Exchange (ETDEWEB)

Sako, Masao; /Pennsylvania U. /KIPAC, Menlo Park; Bassett, Bruce; /Cape Town U. /South African Astron. Observ.; Becker, Andrew; /Washington U., Seattle, Astron. Dept.; Cinabro, David; /Wayne State U.; DeJongh, Don Frederic; /Fermilab; Depoy, D.L.; /Ohio State U.; Doi, Mamoru; /Tokyo U.; Garnavich, Peter M.; /Notre Dame U.; Craig, Hogan, J.; /Washington U., Seattle, Astron. Dept.; Holtzman, Jon; /New Mexico State U.; Jha, Saurabh; /Stanford U., Phys. Dept.; Konishi, Kohki; /Tokyo U.; Lampeitl, Hubert; /Baltimore, Space; Marriner, John; /Fermilab; Miknaitis, Gajus; /Fermilab; Nichol, Robert C.; /Portsmouth U.; Prieto, Jose Luis; /Ohio State U.; Richmond, Michael W.; /Rochester Inst.; Schneider, Donald P.; /Penn State U., Astron. Astrophys.; Smith, Mathew; /Portsmouth U.; SubbaRao, Mark; /Chicago U. /Tokyo U. /Tokyo U. /South African Astron. Observ. /Tokyo

2007-09-14

The Sloan Digital Sky Survey-II Supernova Survey has identified a large number of new transient sources in a 300 deg2 region along the celestial equator during its first two seasons of a three-season campaign. Multi-band (ugriz) light curves were measured for most of the sources, which include solar system objects, Galactic variable stars, active galactic nuclei, supernovae (SNe), and other astronomical transients. The imaging survey is augmented by an extensive spectroscopic follow-up program to identify SNe, measure their redshifts, and study the physical conditions of the explosions and their environment through spectroscopic diagnostics. During the survey, light curves are rapidly evaluated to provide an initial photometric type of the SNe, and a selected sample of sources are targeted for spectroscopic observations. In the first two seasons, 476 sources were selected for spectroscopic observations, of which 403 were identified as SNe. For the Type Ia SNe, the main driver for the Survey, our photometric typing and targeting efficiency is 90%. Only 6% of the photometric SN Ia candidates were spectroscopically classified as non-SN Ia instead, and the remaining 4% resulted in low signal-to-noise, unclassified spectra. This paper describes the search algorithm and the software, and the real-time processing of the SDSS imaging data. We also present the details of the supernova candidate selection procedures and strategies for follow-up spectroscopic and imaging observations of the discovered sources.

Biological and clinical dosimetry. Progress report, 1 October 1976--30 September 1977

International Nuclear Information System (INIS)

Laughlin, J.S.; McDonald, J.C.

1977-01-01

The Sloan--Kettering portable tissue equivalent calorimeter system was employed for a series of measurements in two neutron fields generated at our cyclotron which compared specific charge, measured with a tissue equivalent ionization chamber, to absorbed dose measured with the calorimeter in the same water phantom. The ratio measured for ionization chamber response in a 60 Co gamma-ray field to the response of the same chamber in the neutron fields was found to be 1.08 and 1.06 for fields whose average neutron energies were about 3.5 and 6 MeV, respectively. This is a reflection of the dependence of anti W/sub n/ upon neutron energy, and the values are compared with recent calculations. Initial measurements of the thermal defect in tissue equivalent plastic have established the precision and accuracy of the experimental system. Preliminary indications confirmed our estimates of the thermal properties of the calorimeter. Microdosimetric measurements were carried out in fast neutron, and other fields including those produced by 125 I and soft x-ray sources. A G-M dosimeter was developed and employed to measure the gamma-ray portion of dose in a fast neutron field, and preliminary work was started on development of a compact spherical calorimeter

The Benefit of Attention-to-Memory Depends on the Interplay of Memory Capacity and Memory Load

Science.gov (United States)

Lim, Sung-Joo; Wöstmann, Malte; Geweke, Frederik; Obleser, Jonas

2018-01-01

Humans can be cued to attend to an item in memory, which facilitates and enhances the perceptual precision in recalling this item. Here, we demonstrate that this facilitating effect of attention-to-memory hinges on the overall degree of memory load. The benefit an individual draws from attention-to-memory depends on her overall working memory performance, measured as sensitivity (d′) in a retroactive cue (retro-cue) pitch discrimination task. While listeners maintained 2, 4, or 6 auditory syllables in memory, we provided valid or neutral retro-cues to direct listeners’ attention to one, to-be-probed syllable in memory. Participants’ overall memory performance (i.e., perceptual sensitivity d′) was relatively unaffected by the presence of valid retro-cues across memory loads. However, a more fine-grained analysis using psychophysical modeling shows that valid retro-cues elicited faster pitch-change judgments and improved perceptual precision. Importantly, as memory load increased, listeners’ overall working memory performance correlated with inter-individual differences in the degree to which precision improved (r = 0.39, p = 0.029). Under high load, individuals with low working memory profited least from attention-to-memory. Our results demonstrate that retrospective attention enhances perceptual precision of attended items in memory but listeners’ optimal use of informative cues depends on their overall memory abilities. PMID:29520246

The Benefit of Attention-to-Memory Depends on the Interplay of Memory Capacity and Memory Load

Directory of Open Access Journals (Sweden)

Sung-Joo Lim

2018-02-01

Full Text Available Humans can be cued to attend to an item in memory, which facilitates and enhances the perceptual precision in recalling this item. Here, we demonstrate that this facilitating effect of attention-to-memory hinges on the overall degree of memory load. The benefit an individual draws from attention-to-memory depends on her overall working memory performance, measured as sensitivity (d′ in a retroactive cue (retro-cue pitch discrimination task. While listeners maintained 2, 4, or 6 auditory syllables in memory, we provided valid or neutral retro-cues to direct listeners’ attention to one, to-be-probed syllable in memory. Participants’ overall memory performance (i.e., perceptual sensitivity d′ was relatively unaffected by the presence of valid retro-cues across memory loads. However, a more fine-grained analysis using psychophysical modeling shows that valid retro-cues elicited faster pitch-change judgments and improved perceptual precision. Importantly, as memory load increased, listeners’ overall working memory performance correlated with inter-individual differences in the degree to which precision improved (r = 0.39, p = 0.029. Under high load, individuals with low working memory profited least from attention-to-memory. Our results demonstrate that retrospective attention enhances perceptual precision of attended items in memory but listeners’ optimal use of informative cues depends on their overall memory abilities.

SLOAN DIGITAL SKY SURVEY OBSERVATIONS OF KUIPER BELT OBJECTS: COLORS AND VARIABILITY

International Nuclear Information System (INIS)

Ofek, Eran O.

2012-01-01

Colors of trans-Neptunian objects (TNOs) are used to study the evolutionary processes of bodies in the outskirts of the solar system and to test theories regarding their origin. Here I describe a search for serendipitous Sloan Digital Sky Survey (SDSS) observations of known TNOs and Centaurs. I present a catalog of SDSS photometry, colors, and astrometry of 388 measurements of 42 outer solar system objects. I find weak evidence, at the ≈ 2σ level (per trial), for a correlation between the g – r color and inclination of scattered disk objects and hot classical Kuiper Belt objects. I find a correlation between the g – r color and the angular momentum in the z direction of all the objects in this sample. These findings should be verified using larger samples of TNOs. Light curves as a function of phase angle are constructed for 13 objects. The steepness of the slopes of these light curves suggests that the coherent backscatter mechanism plays a major role in the reflectivity of outer solar system small objects at small phase angles. I find weak evidence for an anticorrelation, significant at the 2σ confidence level (per trial), between the g-band phase-angle slope parameter and the semimajor axis, as well as the aphelion distance, of these objects (i.e., they show a more prominent 'opposition effect' at smaller distances from the Sun). However, this plausible correlation should be verified using a larger sample. I discuss the origin of this possible correlation and argue that if this correlation is real it probably indicates that 'Sedna'-like objects have a different origin than other classes of TNOs. Finally, I identify several objects with large variability amplitudes.

Memory reconsolidation mediates the updating of hippocampal memory content

Directory of Open Access Journals (Sweden)

Jonathan L C Lee

2010-11-01

Full Text Available The retrieval or reactivation of a memory places it into a labile state, requiring a process of reconsolidation to restabilize it. This retrieval-induced plasticity is a potential mechanism for the modification of the existing memory. Following previous data supportive of a functional role for memory reconsolidation in the modification of memory strength, here I show that hippocampal memory reconsolidation also supports the updating of contextual memory content. Using a procedure that separates the learning of pure context from footshock-motivated contextual fear learning, I demonstrate doubly dissociable hippocampal mechanisms of initial context learning and subsequent updating of the neutral contextual representation to incorporate the footshock. Contextual memory consolidation was dependent upon BDNF expression in the dorsal hippocampus, whereas the footshock modification of the contextual representation required the expression of Zif268. These mechanisms match those previously shown to be selectively involved in hippocampal memory consolidation and reconsolidation, respectively. Moreover, memory reactivation is a necessary step in modifying memory content, as inhibition of hippocampal synaptic protein degradation also prevented the footshock-mediated memory modification. Finally, dorsal hippocampal knockdown of Zif268 impaired the reconsolidation of the pure contextual memory only under conditions of weak context memory training, as well as failing to disrupt contextual freezing when a strong contextual fear memory is reactivated by further conditioning. Therefore, an adaptive function of the reactivation and reconsolidation process is to enable the updating of memory content.

The Sloan Digital Sky Survey Quasar Catalog V. Seventh Data Release

Energy Technology Data Exchange (ETDEWEB)

Schneider, Donald P.; /Penn State U.; Richards, Gordon T.; /Drexel U.; Hall, Patrick B.; /York U., Canada; Strauss, Michael A.; /Princeton U. Observ.; Anderson, Scott F.; /Washington U., Seattle, Astron. Dept.; Boroson, Todd A.; /Kitt Peak Observ.; Ross, Nicholas P.; /Penn State U.; Shen, Yue; /Princeton U. Observ.; Brandt, W.N.; /Penn State U.; Fan, Xiaohui; /Arizona U., Astron. Dept. - Steward Observ.; Inada, Naohisa; /Wako, RIKEN /Southampton U. /Heidelberg, Max Planck Inst. Astron.

2010-04-01

We present the fifth edition of the Sloan Digital Sky Survey (SDSS) Quasar Catalog, which is based upon the SDSS Seventh Data Release. The catalog, which contains 105,783 spectroscopically confirmed quasars, represents the conclusion of the SDSS-I and SDSS-II quasar survey. The catalog consists of the SDSS objects that have luminosities larger than M{sub i} = -22.0 (in a cosmology with H{sub 0} = 70 km s{sup -1} Mpc{sup -1}, {Omega}{sub M} = 0.3, and {Omega}{sub {Lambda}} = 0.7), have at least one emission line with FWHM larger than 1000 km s{sup -1} or have interesting/complex absorption features, are fainter than i {approx} 15.0, and have highly reliable redshifts. The catalog covers an area of {approx} 9380 deg{sup 2}. The quasar redshifts range from 0.065 to 5.46, with a median value of 1.49; the catalog includes 1248 quasars at redshifts greater than 4, of which 56 are at redshifts greater than 5. The catalog contains 9210 quasars with i < 18; slightly over half of the entries have i < 19. For each object the catalog presents positions accurate to better than 0.1-inch rms per coordinate, five-band (ugriz) CCD-based photometry with typical accuracy of 0.03 mag, and information on the morphology and selection method. The catalog also contains radio, near-infrared, and X-ray emission properties of the quasars, when available, from other large-area surveys. The calibrated digital spectra cover the wavelength region 3800-9200 {angstrom} at a spectral resolution of {approx_equal} 2000; the spectra can be retrieved from the SDSS public database using the information provided in the catalog. Over 96% of the objects in the catalog were discovered by the SDSS. We also include a supplemental list of an additional 207 quasars with SDSS spectra whose archive photometric information is incomplete.

The Importance of Memory Specificity and Memory Coherence for the Self: Linking Two Characteristics of Autobiographical Memory

Directory of Open Access Journals (Sweden)

Elien Vanderveren

2017-12-01

Full Text Available Autobiographical memory forms a network of memories about personal experiences that defines and supports well-being and effective functioning of the self in various ways. During the last three decades, there have been two characteristics of autobiographical memory that have received special interest regarding their role in psychological well-being and psychopathology, namely memory specificity and memory coherence. Memory specificity refers to the extent to which retrieved autobiographical memories are specific (i.e., memories about a particular experience that happened on a particular day. Difficulty retrieving specific memories interferes with effective functioning of the self and is related to depression and post-traumatic stress disorder. Memory coherence refers to the narrative expression of the overall structure of autobiographical memories. It has likewise been related to psychological well-being and the occurrence of psychopathology. Research on memory specificity and memory coherence has developed as two largely independent research domains, even though they show much overlap. This raises some important theoretical questions. How do these two characteristics of autobiographical memory relate to each other, both theoretically and empirically? Additionally, how can the integration of these two facilitate our understanding of the importance of autobiographical memory for the self? In this article, we give a critical overview of memory specificity and memory coherence and their relation to the self. We link both features of autobiographical memory by describing some important similarities and by formulating hypotheses about how they might relate to each other. By situating both memory specificity and memory coherence within Conway and Pleydell-Pearce’s Self-Memory System, we make a first attempt at a theoretical integration. Finally, we suggest some new and exciting research possibilities and explain how both research fields could benefit

Memory

Science.gov (United States)

... it has to decide what is worth remembering. Memory is the process of storing and then remembering this information. There are different types of memory. Short-term memory stores information for a few ...

The 13th Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the SDSS-IV Survey Mapping Nearby Galaxies at Apache Point Observatory

Science.gov (United States)

Albareti, Franco D.; Allende Prieto, Carlos; Almeida, Andres; Anders, Friedrich; Anderson, Scott; Andrews, Brett H.; Aragón-Salamanca, Alfonso; Argudo-Fernández, Maria; Armengaud, Eric; Aubourg, Eric; Avila-Reese, Vladimir; Badenes, Carles; Bailey, Stephen; Barbuy, Beatriz; Barger, Kat; Barrera-Ballesteros, Jorge; Bartosz, Curtis; Basu, Sarbani; Bates, Dominic; Battaglia, Giuseppina; Baumgarten, Falk; Baur, Julien; Bautista, Julian; Beers, Timothy C.; Belfiore, Francesco; Bershady, Matthew; Bertran de Lis, Sara; Bird, Jonathan C.; Bizyaev, Dmitry; Blanc, Guillermo A.; Blanton, Michael; Blomqvist, Michael; Bolton, Adam S.; Borissova, J.; Bovy, Jo; Nielsen Brandt, William; Brinkmann, Jonathan; Brownstein, Joel R.; Bundy, Kevin; Burtin, Etienne; Busca, Nicolás G.; Orlando Camacho Chavez, Hugo; Cano Díaz, M.; Cappellari, Michele; Carrera, Ricardo; Chen, Yanping; Cherinka, Brian; Cheung, Edmond; Chiappini, Cristina; Chojnowski, Drew; Chuang, Chia-Hsun; Chung, Haeun; Cirolini, Rafael Fernando; Clerc, Nicolas; Cohen, Roger E.; Comerford, Julia M.; Comparat, Johan; Correa do Nascimento, Janaina; Cousinou, Marie-Claude; Covey, Kevin; Crane, Jeffrey D.; Croft, Rupert; Cunha, Katia; Darling, Jeremy; Davidson, James W., Jr.; Dawson, Kyle; Da Costa, Luiz; Da Silva Ilha, Gabriele; Deconto Machado, Alice; Delubac, Timothée; De Lee, Nathan; De la Macorra, Axel; De la Torre, Sylvain; Diamond-Stanic, Aleksandar M.; Donor, John; Downes, Juan Jose; Drory, Niv; Du, Cheng; Du Mas des Bourboux, Hélion; Dwelly, Tom; Ebelke, Garrett; Eigenbrot, Arthur; Eisenstein, Daniel J.; Elsworth, Yvonne P.; Emsellem, Eric; Eracleous, Michael; Escoffier, Stephanie; Evans, Michael L.; Falcón-Barroso, Jesús; Fan, Xiaohui; Favole, Ginevra; Fernandez-Alvar, Emma; Fernandez-Trincado, J. G.; Feuillet, Diane; Fleming, Scott W.; Font-Ribera, Andreu; Freischlad, Gordon; Frinchaboy, Peter; Fu, Hai; Gao, Yang; Garcia, Rafael A.; Garcia-Dias, R.; Garcia-Hernández, D. A.; Garcia Pérez, Ana E.; Gaulme, Patrick; Ge, Junqiang; Geisler, Douglas; Gillespie, Bruce; Gil Marin, Hector; Girardi, Léo; Goddard, Daniel; Gomez Maqueo Chew, Yilen; Gonzalez-Perez, Violeta; Grabowski, Kathleen; Green, Paul; Grier, Catherine J.; Grier, Thomas; Guo, Hong; Guy, Julien; Hagen, Alex; Hall, Matt; Harding, Paul; Harley, R. E.; Hasselquist, Sten; Hawley, Suzanne; Hayes, Christian R.; Hearty, Fred; Hekker, Saskia; Hernandez Toledo, Hector; Ho, Shirley; Hogg, David W.; Holley-Bockelmann, Kelly; Holtzman, Jon A.; Holzer, Parker H.; Hu, Jian; Huber, Daniel; Hutchinson, Timothy Alan; Hwang, Ho Seong; Ibarra-Medel, Héctor J.; Ivans, Inese I.; Ivory, KeShawn; Jaehnig, Kurt; Jensen, Trey W.; Johnson, Jennifer A.; Jones, Amy; Jullo, Eric; Kallinger, T.; Kinemuchi, Karen; Kirkby, David; Klaene, Mark; Kneib, Jean-Paul; Kollmeier, Juna A.; Lacerna, Ivan; Lane, Richard R.; Lang, Dustin; Laurent, Pierre; Law, David R.; Leauthaud, Alexie; Le Goff, Jean-Marc; Li, Chen; Li, Cheng; Li, Niu; Li, Ran; Liang, Fu-Heng; Liang, Yu; Lima, Marcos; Lin, Lihwai; Lin, Lin; Lin, Yen-Ting; Liu, Chao; Long, Dan; Lucatello, Sara; MacDonald, Nicholas; MacLeod, Chelsea L.; Mackereth, J. Ted; Mahadevan, Suvrath; Geimba Maia, Marcio Antonio; Maiolino, Roberto; Majewski, Steven R.; Malanushenko, Olena; Malanushenko, Viktor; Dullius Mallmann, Nícolas; Manchado, Arturo; Maraston, Claudia; Marques-Chaves, Rui; Martinez Valpuesta, Inma; Masters, Karen L.; Mathur, Savita; McGreer, Ian D.; Merloni, Andrea; Merrifield, Michael R.; Meszáros, Szabolcs; Meza, Andres; Miglio, Andrea; Minchev, Ivan; Molaverdikhani, Karan; Montero-Dorta, Antonio D.; Mosser, Benoit; Muna, Demitri; Myers, Adam; Nair, Preethi; Nandra, Kirpal; Ness, Melissa; Newman, Jeffrey A.; Nichol, Robert C.; Nidever, David L.; Nitschelm, Christian; O’Connell, Julia; Oravetz, Audrey; Oravetz, Daniel J.; Pace, Zachary; Padilla, Nelson; Palanque-Delabrouille, Nathalie; Pan, Kaike; Parejko, John; Paris, Isabelle; Park, Changbom; Peacock, John A.; Peirani, Sebastien; Pellejero-Ibanez, Marcos; Penny, Samantha; Percival, Will J.; Percival, Jeffrey W.; Perez-Fournon, Ismael; Petitjean, Patrick; Pieri, Matthew; Pinsonneault, Marc H.; Pisani, Alice; Prada, Francisco; Prakash, Abhishek; Price-Jones, Natalie; Raddick, M. Jordan; Rahman, Mubdi; Raichoor, Anand; Barboza Rembold, Sandro; Reyna, A. M.; Rich, James; Richstein, Hannah; Ridl, Jethro; Riffel, Rogemar A.; Riffel, Rogério; Rix, Hans-Walter; Robin, Annie C.; Rockosi, Constance M.; Rodríguez-Torres, Sergio; Rodrigues, Thaíse S.; Roe, Natalie; Lopes, A. Roman; Román-Zúñiga, Carlos; Ross, Ashley J.; Rossi, Graziano; Ruan, John; Ruggeri, Rossana; Runnoe, Jessie C.; Salazar-Albornoz, Salvador; Salvato, Mara; Sanchez, Sebastian F.; Sanchez, Ariel G.; Sanchez-Gallego, José R.; Santiago, Basílio Xavier; Schiavon, Ricardo; Schimoia, Jaderson S.; Schlafly, Eddie; Schlegel, David J.; Schneider, Donald P.; Schönrich, Ralph; Schultheis, Mathias; Schwope, Axel; Seo, Hee-Jong; Serenelli, Aldo; Sesar, Branimir; Shao, Zhengyi; Shetrone, Matthew; Shull, Michael; Silva Aguirre, Victor; Skrutskie, M. F.; Slosar, Anže; Smith, Michael; Smith, Verne V.; Sobeck, Jennifer; Somers, Garrett; Souto, Diogo; Stark, David V.; Stassun, Keivan G.; Steinmetz, Matthias; Stello, Dennis; Storchi Bergmann, Thaisa; Strauss, Michael A.; Streblyanska, Alina; Stringfellow, Guy S.; Suarez, Genaro; Sun, Jing; Taghizadeh-Popp, Manuchehr; Tang, Baitian; Tao, Charling; Tayar, Jamie; Tembe, Mita; Thomas, Daniel; Tinker, Jeremy; Tojeiro, Rita; Tremonti, Christy; Troup, Nicholas; Trump, Jonathan R.; Unda-Sanzana, Eduardo; Valenzuela, O.; Van den Bosch, Remco; Vargas-Magaña, Mariana; Vazquez, Jose Alberto; Villanova, Sandro; Vivek, M.; Vogt, Nicole; Wake, David; Walterbos, Rene; Wang, Yuting; Wang, Enci; Weaver, Benjamin Alan; Weijmans, Anne-Marie; Weinberg, David H.; Westfall, Kyle B.; Whelan, David G.; Wilcots, Eric; Wild, Vivienne; Williams, Rob A.; Wilson, John; Wood-Vasey, W. M.; Wylezalek, Dominika; Xiao, Ting; Yan, Renbin; Yang, Meng; Ybarra, Jason E.; Yeche, Christophe; Yuan, Fang-Ting; Zakamska, Nadia; Zamora, Olga; Zasowski, Gail; Zhang, Kai; Zhao, Cheng; Zhao, Gong-Bo; Zheng, Zheng; Zheng, Zheng; Zhou, Zhi-Min; Zhu, Guangtun; Zinn, Joel C.; Zou, Hu

2017-12-01

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) began observations in 2014 July. It pursues three core programs: the Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2), Mapping Nearby Galaxies at APO (MaNGA), and the Extended Baryon Oscillation Spectroscopic Survey (eBOSS). As well as its core program, eBOSS contains two major subprograms: the Time Domain Spectroscopic Survey (TDSS) and the SPectroscopic IDentification of ERosita Sources (SPIDERS). This paper describes the first data release from SDSS-IV, Data Release 13 (DR13). DR13 makes publicly available the first 1390 spatially resolved integral field unit observations of nearby galaxies from MaNGA. It includes new observations from eBOSS, completing the Sloan Extended QUasar, Emission-line galaxy, Luminous red galaxy Survey (SEQUELS), which also targeted variability-selected objects and X-ray-selected objects. DR13 includes new reductions of the SDSS-III BOSS data, improving the spectrophotometric calibration and redshift classification, and new reductions of the SDSS-III APOGEE-1 data, improving stellar parameters for dwarf stars and cooler stars. DR13 provides more robust and precise photometric calibrations. Value-added target catalogs relevant for eBOSS, TDSS, and SPIDERS and an updated red-clump catalog for APOGEE are also available. This paper describes the location and format of the data and provides references to important technical papers. The SDSS web site, http://www.sdss.org, provides links to the data, tutorials, examples of data access, and extensive documentation of the reduction and analysis procedures. DR13 is the first of a scheduled set that will contain new data and analyses from the planned ∼6 yr operations of SDSS-IV.

A Full Year's Chandra Exposure on Sloan Digital Sky Survey Quasars from the Chandra Multiwavelength Project

Science.gov (United States)

Green, Paul J.; Aldcroft, T. L.; Richards, G. T.; Barkhouse, W. A.; Constantin, A.; Haggard, D.; Karovska, M.; Kim, D.-W.; Kim, M.; Vikhlinin, A.; Anderson, S. F.; Mossman, A.; Kashyap, V.; Myers, A. D.; Silverman, J. D.; Wilkes, B. J.; Tananbaum, H.

2009-01-01

We study the spectral energy distributions and evolution of a large sample of optically selected quasars from the Sloan Digital Sky Survey that were observed in 323 Chandra images analyzed by the Chandra Multiwavelength Project. Our highest-confidence matched sample includes 1135 X-ray detected quasars in the redshift range 0.2 3, substantially expanding the known sample. We find no evidence for evolution out to z ~ 5 for either the X-ray photon index Γ or for the ratio of optical/UV to X-ray flux αox. About 10% of detected QSOs show best-fit intrinsic absorbing columns greater than 1022 cm-2, but the fraction might reach ~1/3 if most nondetections are absorbed. We confirm a significant correlation between αox and optical luminosity, but it flattens or disappears for fainter (MB gsim -23) active galactic nucleus (AGN) alone. We report significant hardening of Γ both toward higher X-ray luminosity, and for relatively X-ray loud quasars. These trends may represent a relative increase in nonthermal X-ray emission, and our findings thereby strengthen analogies between Galactic black hole binaries and AGN. For uniformly selected subsamples of narrow-line Seyfert 1s and narrow absorption line QSOs, we find no evidence for unusual distributions of either αox or Γ.

Cognitive memory.

Science.gov (United States)

Widrow, Bernard; Aragon, Juan Carlos

2013-05-01

Regarding the workings of the human mind, memory and pattern recognition seem to be intertwined. You generally do not have one without the other. Taking inspiration from life experience, a new form of computer memory has been devised. Certain conjectures about human memory are keys to the central idea. The design of a practical and useful "cognitive" memory system is contemplated, a memory system that may also serve as a model for many aspects of human memory. The new memory does not function like a computer memory where specific data is stored in specific numbered registers and retrieval is done by reading the contents of the specified memory register, or done by matching key words as with a document search. Incoming sensory data would be stored at the next available empty memory location, and indeed could be stored redundantly at several empty locations. The stored sensory data would neither have key words nor would it be located in known or specified memory locations. Sensory inputs concerning a single object or subject are stored together as patterns in a single "file folder" or "memory folder". When the contents of the folder are retrieved, sights, sounds, tactile feel, smell, etc., are obtained all at the same time. Retrieval would be initiated by a query or a prompt signal from a current set of sensory inputs or patterns. A search through the memory would be made to locate stored data that correlates with or relates to the prompt input. The search would be done by a retrieval system whose first stage makes use of autoassociative artificial neural networks and whose second stage relies on exhaustive search. Applications of cognitive memory systems have been made to visual aircraft identification, aircraft navigation, and human facial recognition. Concerning human memory, reasons are given why it is unlikely that long-term memory is stored in the synapses of the brain's neural networks. Reasons are given suggesting that long-term memory is stored in DNA or RNA

Recall in older cancer patients: measuring memory for medical information

NARCIS (Netherlands)

Jansen, J.; Weert, J. van; Meulen, N. van der; Dulmen, S. van; Heeren, Th.; Bensing, J.

2008-01-01

Purpose: Remembering medical treatment information may be particularly taxing for older cancer patients, but to our knowledge this ability has never been assessed in this specific age group only. Our purpose in this study was to investigate older cancer patients’ recall of information after

Recall in older cancer patients: measuring memory for medical information.

NARCIS (Netherlands)

Jansen, J.; Weert, J. van; Meulen, N. van der; Dulmen, S. van; Heeren, T.; Bensing, J.

2008-01-01

PURPOSE: Remembering medical treatment information may be particularly taxing for older cancer patients, but to our knowledge this ability has never been assessed in this specific age group only. Our purpose in this study was to investigate older cancer patients' recall of information after patient

Recall in older cancer patients: Measuring memory for medical information

NARCIS (Netherlands)

Jansen, J.; van Weert, J.; van der Meulen, N.; van Dulmen, S.; Heeren, T.; Bensing, J.

2008-01-01

Purpose: Remembering medical treatment information may be particularly taxing for older cancer patients, but to our knowledge this ability has never been assessed in this specific age group only. Our purpose in this study was to investigate older cancer patients' recall of information after patient

The contributions of handedness and working memory to episodic memory.

Science.gov (United States)

Sahu, Aparna; Christman, Stephen D; Propper, Ruth E

2016-11-01

Past studies have independently shown associations of working memory and degree of handedness with episodic memory retrieval. The current study takes a step ahead by examining whether handedness and working memory independently predict episodic memory. In agreement with past studies, there was an inconsistent-handed advantage for episodic memory; however, this advantage was absent for working memory tasks. Furthermore, regression analyses showed handedness, and complex working memory predicted episodic memory performance at different times. Results are discussed in light of theories of episodic memory and hemispheric interaction.

Memory Dysfunction

Science.gov (United States)

Matthews, Brandy R.

2015-01-01

Purpose of Review: This article highlights the dissociable human memory systems of episodic, semantic, and procedural memory in the context of neurologic illnesses known to adversely affect specific neuroanatomic structures relevant to each memory system. Recent Findings: Advances in functional neuroimaging and refinement of neuropsychological and bedside assessment tools continue to support a model of multiple memory systems that are distinct yet complementary and to support the potential for one system to be engaged as a compensatory strategy when a counterpart system fails. Summary: Episodic memory, the ability to recall personal episodes, is the subtype of memory most often perceived as dysfunctional by patients and informants. Medial temporal lobe structures, especially the hippocampal formation and associated cortical and subcortical structures, are most often associated with episodic memory loss. Episodic memory dysfunction may present acutely, as in concussion; transiently, as in transient global amnesia (TGA); subacutely, as in thiamine deficiency; or chronically, as in Alzheimer disease. Semantic memory refers to acquired knowledge about the world. Anterior and inferior temporal lobe structures are most often associated with semantic memory loss. The semantic variant of primary progressive aphasia (svPPA) is the paradigmatic disorder resulting in predominant semantic memory dysfunction. Working memory, associated with frontal lobe function, is the active maintenance of information in the mind that can be potentially manipulated to complete goal-directed tasks. Procedural memory, the ability to learn skills that become automatic, involves the basal ganglia, cerebellum, and supplementary motor cortex. Parkinson disease and related disorders result in procedural memory deficits. Most memory concerns warrant bedside cognitive or neuropsychological evaluation and neuroimaging to assess for specific neuropathologies and guide treatment. PMID:26039844

Behavioural memory reconsolidation of food and fear memories.

Science.gov (United States)

Flavell, Charlotte R; Barber, David J; Lee, Jonathan L C

2011-10-18

The reactivation of a memory through retrieval can render it subject to disruption or modification through the process of memory reconsolidation. In both humans and rodents, briefly reactivating a fear memory results in effective erasure by subsequent extinction training. Here we show that a similar strategy is equally effective in the disruption of appetitive pavlovian cue-food memories. However, systemic administration of the NMDA receptor partial agonist D-cycloserine, under the same behavioural conditions, did not potentiate appetitive memory extinction, suggesting that reactivation does not enhance subsequent extinction learning. To confirm that reactivation followed by extinction reflects a behavioural analogue of memory reconsolidation, we show that prevention of contextual fear memory reactivation by the L-type voltage-gated calcium channel blocker nimodipine interferes with the amnestic outcome. Therefore, the reconsolidation process can be manipulated behaviourally to disrupt both aversive and appetitive memories. © 2011 Macmillan Publishers Limited. All rights reserved.

Delirium assessed by Memorial Delirium Assessment Scale in advanced cancer patients admitted to an acute palliative/supportive care unit.

Science.gov (United States)

Mercadante, Sebastiano; Adile, Claudio; Ferrera, Patrizia; Cortegiani, Andrea; Casuccio, Alessandra

2017-07-01

Delirium is often unrecognized in cancer patients. The aim of this study was to investigate the prevalence of delirium assessed by the Memorial Delirium Assessment Scale (MDAS) and possible associated factors on admission to an acute palliative/supportive care unit (APSCU). The secondary outcome was to assess changes in MDAS and symptom burden at time of discharge. A consecutive sample of advanced cancer patients who were admitted to an APSCU was prospectively assessed for a period of 10 months. Patient demographics, including age, gender, primary diagnosis, Karnofsky status, stage of disease, and educational level were collected. The Edmonton Symptom Assessment Scale (ESAS) and the MDAS were measured at hospital admission and discharge. A total of 314 patients were surveyed. Of 292 patients with MDAS available at T0, 74 (25.3%) and 24 (8.2%) had a MDAS of 7-12 and ≥13, respectively. At discharge, there was a significant decrease in the number of patients with a MDAS ≥7/30. Higher values of MDAS were associated with age (p = .028), a lower Karnofsky status (p symptoms (p = .026), hospital stay (p = .038) and death (p Delirium is highly prevalent in patients admitted to APSCU, characterized by a low mortality due to early referral. Comprehensive assessment and treatment may allow a decrease in the level of cognitive disorders and symptom burden.

Surgical management of metastatic differentiated thyroid cancer

International Nuclear Information System (INIS)

Fakih, A.R.; Mistry, R.C.

1999-01-01

The differentiated management of metastatic differentiated thyroid cancer (DTC) with lymph node and/or systemic metastases is very much a treatable cancer. Interaction between the surgeon and the nuclear medicine specialist is essential to ensure quality survival in these patient. This review is confined to surgical aspects and is based on experience with 417 patients who were operated for DTC at the Tata Memorial Hospital between 1971 and 1985

Coping with cancer-related cognitive dysfunction: a scoping review of the literature.

Science.gov (United States)

Sleight, Alix

2016-01-01

Cancer-related cognitive dysfunction (CRCD) impacts memory, attention, concentration, language, multi-tasking, and organizational skills and decreases participation and quality of life for cancer survivors. The objectives of this article are: (1) to outline the neuroscience of CRCD, its risk factors, and its effect on participation; and (2) to identify and summarize the literature on rehabilitation interventions and coping techniques for CRCD in cancer survivors. A scoping review of articles cited in PubMed, MEDLINE, PsychINFO, and CINAHL was performed. To be included, articles must have been published in a peer-reviewed scientific journal between 1996 and 2014, written in English, and included a quantitative or qualitative non-pharmacological study of interventions and/or coping strategies for adult cancer survivors experiencing CRCD. Ten articles met the inclusion criteria for final review. Six studies tested the efficacy of rehabilitation treatments on CRCD. Three involved cognitive-behavioral therapy (CBT), while three tested neuropsychological and/or cognitive training interventions. Four qualitative studies investigated coping strategies used by survivors with CRCD. CBT-based treatments and neuropsychological/cognitive training methods may ameliorate symptoms of CRCD. The most commonly-reported coping strategy is utilization of assistive technology and memory aids. Further research is needed about efficacious rehabilitation techniques for this population. Implications for Rehabilitation Cancer-related cognitive dysfunction (CRCD) may impact up to 50% of cancer survivors. CRCD can significantly decrease participation and quality of life during survivorship. Cognitive-behavioral therapy (CBT) and neuropsychological/cognitive training methods may ameliorate symptoms of CRCD. The most common coping strategy reported by cancer survivors with CRCD is the use of assistive technology and memory aids.

Memory reconsolidation mediates the updating of hippocampal memory content

OpenAIRE

Jonathan L C Lee

2010-01-01

The retrieval or reactivation of a memory places it into a labile state, requiring a process of reconsolidation to restabilize it. This retrieval-induced plasticity is a potential mechanism for the modification of the existing memory. Following previous data supportive of a functional role for memory reconsolidation in the modification of memory strength, here I show that hippocampal memory reconsolidation also supports the updating of contextual memory content. Using a procedure that se...

Memory enhancement by Tamoxifen on amyloidosis mouse model.

Science.gov (United States)

Pandey, Deepika; Banerjee, Sugato; Basu, Mahua; Mishra, Nibha

2016-03-01

Tamoxifen (TMX) is a selective estrogen receptor modulator (SERM) used in the treatment of breast cancer. Earlier studies show its neuroprotection via regulating apoptosis, microglial functions, and synaptic plasticity. TMX also showed memory enhancement in ovariectomized mice, and protection from amyloid induced damage in hippocampal cell line. These reports encouraged us to explore the role of TMX in relevance to Alzheimer's disease (AD). We report here, the effect of TMX treatment a) on memory, and b) levels of neurotransmitters (acetylcholine (ACh) and dopamine (DA)) in breeding-retired-female mice injected with beta amyloid1-42 (Aβ1-42). Mice were treated with TMX (10mg/kg, i.p.) for 15 days. In Morris water maze test, the TMX treated mice escape latency decreased during training trials. They also spent longer time in the platform quadrant on probe trial, compared to controls. In Passive avoidance test, TMX treated mice avoided stepping on the shock chamber. This suggests that TMX protects memory from Aβ induced toxicity. In frontal cortex, ACh was moderately increased, with TMX treatment. In striatum, dopamine was significantly increased, 3,4-dihydroxyphenylacetic acid (DOPAC) level and DOPAC/DA ratio was decreased post TMX treatment. Therefore, TMX enhances spatial and contextual memory by reducing dopamine metabolism and increasing ACh level in Aβ1-42 injected-breeding-retired-female mice. Copyright © 2015. Published by Elsevier Inc.

Recall in older cancer patients: measuring memory for medical information.

Science.gov (United States)

Jansen, Jesse; van Weert, Julia; van der Meulen, Nienke; van Dulmen, Sandra; Heeren, Thea; Bensing, Jozien

2008-04-01

Remembering medical treatment information may be particularly taxing for older cancer patients, but to our knowledge this ability has never been assessed in this specific age group only. Our purpose in this study was to investigate older cancer patients' recall of information after patient education preceding chemotherapy. We constructed a recall questionnaire consisting of multiple-choice questions, completion items, and open-ended questions related to information about treatment and recommendations on how to handle side effects. Immediately after a nursing consultation preceding chemotherapy treatment, 69 older patients (M = 71.8 years, SD = 4.1) completed the questionnaire. We checked recall against the actual communication in video recordings of the consultations. On average, 82.2 items were discussed during the consultations. The mean percentage of information recalled correctly was 23.2% for open-ended questions, 68.0% for completion items, and 80.2% for multiple-choice questions. Older cancer patients are confronted with a lot of information. Recall of information strongly depended on question format; especially active reproduction appeared to be poor. To improve treatment outcomes, it is important that cancer patients are able to actively retrieve knowledge about how to prevent and recognize adverse side effects and that this is checked by the health professional. We make suggestions on how to make information more memorable for older cancer patients.

Organizational memory: from expectations memory to procedural memory

NARCIS (Netherlands)

Ebbers, J.J.; Wijnberg, N.M.

2009-01-01

Organizational memory is not just the stock of knowledge about how to do things, but also of expectations of organizational members vis-à-vis each other and the organization as a whole. The central argument of this paper is that this second type of organizational memory -organizational expectations

Aging Memories: Differential Decay of Episodic Memory Components

Science.gov (United States)

Talamini, Lucia M.; Gorree, Eva

2012-01-01

Some memories about events can persist for decades, even a lifetime. However, recent memories incorporate rich sensory information, including knowledge on the spatial and temporal ordering of event features, while old memories typically lack this "filmic" quality. We suggest that this apparent change in the nature of memories may reflect a…

Working memory, long-term memory, and medial temporal lobe function

Science.gov (United States)

Jeneson, Annette; Squire, Larry R.

2012-01-01

Early studies of memory-impaired patients with medial temporal lobe (MTL) damage led to the view that the hippocampus and related MTL structures are involved in the formation of long-term memory and that immediate memory and working memory are independent of these structures. This traditional idea has recently been revisited. Impaired performance in patients with MTL lesions on tasks with short retention intervals, or no retention interval, and neuroimaging findings with similar tasks have been interpreted to mean that the MTL is sometimes needed for working memory and possibly even for visual perception itself. We present a reappraisal of this interpretation. Our main conclusion is that, if the material to be learned exceeds working memory capacity, if the material is difficult to rehearse, or if attention is diverted, performance depends on long-term memory even when the retention interval is brief. This fundamental notion is better captured by the terms subspan memory and supraspan memory than by the terms short-term memory and long-term memory. We propose methods for determining when performance on short-delay tasks must depend on long-term (supraspan) memory and suggest that MTL lesions impair performance only when immediate memory and working memory are insufficient to support performance. In neuroimaging studies, MTL activity during encoding is influenced by the memory load and correlates positively with long-term retention of the material that was presented. The most parsimonious and consistent interpretation of all the data is that subspan memoranda are supported by immediate memory and working memory and are independent of the MTL. PMID:22180053

Single-item memory, associative memory, and the human hippocampus

OpenAIRE

Gold, Jeffrey J.; Hopkins, Ramona O.; Squire, Larry R.

2006-01-01

We tested recognition memory for items and associations in memory-impaired patients with bilateral lesions thought to be limited to the hippocampal region. In Experiment 1 (Combined memory test), participants studied words and then took a memory test in which studied words, new words, studied word pairs, and recombined word pairs were presented in a mixed order. In Experiment 2 (Separated memory test), participants studied single words and then took a memory test involving studied word and ne...

Memory systems interaction in the pigeon: working and reference memory.

Science.gov (United States)

Roberts, William A; Strang, Caroline; Macpherson, Krista

2015-04-01

Pigeons' performance on a working memory task, symbolic delayed matching-to-sample, was used to examine the interaction between working memory and reference memory. Reference memory was established by training pigeons to discriminate between the comparison cues used in delayed matching as S+ and S- stimuli. Delayed matching retention tests then measured accuracy when working and reference memory were congruent and incongruent. In 4 experiments, it was shown that the interaction between working and reference memory is reciprocal: Strengthening either type of memory leads to a decrease in the influence of the other type of memory. A process dissociation procedure analysis of the data from Experiment 4 showed independence of working and reference memory, and a model of working memory and reference memory interaction was shown to predict the findings reported in the 4 experiments. (PsycINFO Database Record (c) 2015 APA, all rights reserved).

The Vast Universe of T Cell Diversity: Subsets of Memory Cells and Their Differentiation.

Science.gov (United States)

Jandus, Camilla; Usatorre, Amaia Martínez; Viganò, Selena; Zhang, Lianjun; Romero, Pedro

2017-01-01

The T cell receptor confers specificity for antigen recognition to T cells. By the first encounter with the cognate antigen, reactive T cells initiate a program of expansion and differentiation that will define not only the ultimate quantity of specific cells that will be generated, but more importantly their quality and functional heterogeneity. Recent achievements using mouse model infection systems have helped to shed light into the complex network of factors that dictate and sustain memory T cell differentiation, ranging from antigen load, TCR signal strength, metabolic fitness, transcriptional programs, and proliferative potential. The different models of memory T cell differentiation are discussed in this chapter, and key phenotypic and functional attributes of memory T cell subsets are presented, both for mouse and human cells. Therapeutic manipulation of memory T cell generation is expected to provide novel unique ways to optimize current immunotherapies, both in infection and cancer.

Declarative memory.

Science.gov (United States)

Riedel, Wim J; Blokland, Arjan

2015-01-01

Declarative Memory consists of memory for events (episodic memory) and facts (semantic memory). Methods to test declarative memory are key in investigating effects of potential cognition-enhancing substances--medicinal drugs or nutrients. A number of cognitive performance tests assessing declarative episodic memory tapping verbal learning, logical memory, pattern recognition memory, and paired associates learning are described. These tests have been used as outcome variables in 34 studies in humans that have been described in the literature in the past 10 years. Also, the use of episodic tests in animal research is discussed also in relation to the drug effects in these tasks. The results show that nutritional supplementation of polyunsaturated fatty acids has been investigated most abundantly and, in a number of cases, but not all, show indications of positive effects on declarative memory, more so in elderly than in young subjects. Studies investigating effects of registered anti-Alzheimer drugs, cholinesterase inhibitors in mild cognitive impairment, show positive and negative effects on declarative memory. Studies mainly carried out in healthy volunteers investigating the effects of acute dopamine stimulation indicate enhanced memory consolidation as manifested specifically by better delayed recall, especially at time points long after learning and more so when drug is administered after learning and if word lists are longer. The animal studies reveal a different picture with respect to the effects of different drugs on memory performance. This suggests that at least for episodic memory tasks, the translational value is rather poor. For the human studies, detailed parameters of the compositions of word lists for declarative memory tests are discussed and it is concluded that tailored adaptations of tests to fit the hypothesis under study, rather than "off-the-shelf" use of existing tests, are recommended.

False memories in highly superior autobiographical memory individuals

Science.gov (United States)

Patihis, Lawrence; Frenda, Steven J.; LePort, Aurora K. R.; Petersen, Nicole; Nichols, Rebecca M.; Stark, Craig E. L.; McGaugh, James L.; Loftus, Elizabeth F.

2013-01-01

The recent identification of highly superior autobiographical memory (HSAM) raised the possibility that there may be individuals who are immune to memory distortions. We measured HSAM participants’ and age- and sex-matched controls’ susceptibility to false memories using several research paradigms. HSAM participants and controls were both susceptible to false recognition of nonpresented critical lure words in an associative word-list task. In a misinformation task, HSAM participants showed higher overall false memory compared with that of controls for details in a photographic slideshow. HSAM participants were equally as likely as controls to mistakenly report they had seen nonexistent footage of a plane crash. Finding false memories in a superior-memory group suggests that malleable reconstructive mechanisms may be fundamental to episodic remembering. Paradoxically, HSAM individuals may retrieve abundant and accurate autobiographical memories using fallible reconstructive processes. PMID:24248358

False memories and memory confidence in borderline patients.

Science.gov (United States)

Schilling, Lisa; Wingenfeld, Katja; Spitzer, Carsten; Nagel, Matthias; Moritz, Steffen

2013-12-01

Mixed results have been obtained regarding memory in patients with borderline personality disorder (BPD). Prior reports and anecdotal evidence suggests that patients with BPD are prone to false memories but this assumption has to been put to firm empirical test, yet. Memory accuracy and confidence was assessed in 20 BPD patients and 22 healthy controls using a visual variant of the false memory (Deese-Roediger-McDermott) paradigm which involved a negative and a positive-valenced picture. Groups did not differ regarding veridical item recognition. Importantly, patients did not display more false memories than controls. At trend level, borderline patients rated more items as new with high confidence compared to healthy controls. The results tentatively suggest that borderline patients show uncompromised visual memory functions and display no increased susceptibility for distorted memories. Copyright © 2013 Elsevier Ltd. All rights reserved.

The accessibility of memory items in children’s working memory

OpenAIRE

Roome, Hannah; Towse, John

2016-01-01

This thesis investigates the processes and systems that support recall in working memory. In particular it seeks to apply ideas from the adult-based dual-memory framework (Unsworth & Engle, 2007b) that claims primary memory and secondary memory are independent contributors to working memory capacity. These two memory systems are described as domain-general processes that combine control of attention and basic memory abilities to retain information. The empirical contribution comprises five ex...

Value Tools in Managed Care Decision Making: Current Hurdles and Future Opportunities.

Science.gov (United States)

Schafer, Jeremy; Galante, Dominic; Shafrin, Jason

2017-06-01

Organizations such as the National Comprehensive Cancer Network, American Society of Clinical Oncology, Institute for Clinical and Economic Review, and Memorial Sloan Kettering have created distinct tools to help different stakeholders assess the value of oncology treatments. However, the oncology value tools were not necessarily created for payers, and it is unclear whether payers are using these tools as part of their drug management process. To understand what value tools payers are using in oncology management and what benefits and shortcomings the tools may have from the payer perspective. A survey targeting drug coverage decision makers at health plans was conducted in August 2016. Respondents attesting to using 2 or more value tools in drug management were eligible for an additional in-depth interview to understand the respondents' perceived benefits and shortcomings of current value tools. Respondents also were asked to describe desired attributes of a hypothetical payer-centric value tool. A total of 28 respondents representing approximately 160 million commercially insured medical lives completed the survey. Twenty respondents (71%) reported using at least 1 value tool in their drug management process. Twelve respondents (43%) used at least 2 tools, and 4 respondents (14%) used at least 3 tools. A total of 6 respondents were selected for in-depth interviews. Interviewees praised value tools for advancing the discussion on drug value and incorporating clinical evidence. However, interviewees felt available value tools varied on providing firm recommendations and relevant price benchmarks. Respondents most commonly recommended the following attributes of a proposed payer-centric value framework: taking a firm position on product value; product comparisons in lieu of comparative clinical trials; web-based tool access; and tool updates at least quarterly. Interview respondents also expressed some support for allowing manipulation of inputs and inclusion of

Stochastic memory: getting memory out of noise

Science.gov (United States)

Stotland, Alexander; di Ventra, Massimiliano

2011-03-01

Memory circuit elements, namely memristors, memcapacitors and meminductors, can store information without the need of a power source. These systems are generally defined in terms of deterministic equations of motion for the state variables that are responsible for memory. However, in real systems noise sources can never be eliminated completely. One would then expect noise to be detrimental for memory. Here, we show that under specific conditions on the noise intensity memory can actually be enhanced. We illustrate this phenomenon using a physical model of a memristor in which the addition of white noise into the state variable equation improves the memory and helps the operation of the system. We discuss under which conditions this effect can be realized experimentally, discuss its implications on existing memory systems discussed in the literature, and also analyze the effects of colored noise. Work supported in part by NSF.

The dependence of galaxy clustering on tidal environment in the Sloan Digital Sky Survey

Science.gov (United States)

Paranjape, Aseem; Hahn, Oliver; Sheth, Ravi K.

2018-06-01

The influence of the Cosmic Web on galaxy formation and evolution is of great observational and theoretical interest. We investigate whether the Cosmic Web leaves an imprint in the spatial clustering of galaxies in the Sloan Digital Sky Survey (SDSS), using the group catalogue of Yang et al. and tidal field estimates at ˜2 h-1 Mpc scales from the mass-tides-velocity data set of Wang et al. We use the tidal anisotropy α (Paranjape et al.) to characterize the tidal environment of groups, and measure the redshift-space 2-point correlation function (2pcf) of group positions and the luminosity- and colour-dependent clustering of group galaxies using samples segregated by α. We find that all the 2pcf measurements depend strongly on α, with factors of ˜20 between the large-scale 2pcf of objects in the most and least isotropic environments. To test whether these strong trends imply `beyond halo mass' effects for galaxy evolution, we compare our results with corresponding 2pcf measurements in mock catalogues constructed using a halo occupation distribution that uses only halo mass as an input. We find that this prescription qualitatively reproduces all observed trends, and also quantitatively matches many of the observed results. Although there are some statistically significant differences between our `halo mass only' mocks and the data - in the most and least isotropic environments - which deserve further investigation, our results suggest that if the tidal environment induces additional effects on galaxy properties other than those inherited from their host haloes, then these must be weak.

A model of memory impairment in schizophrenia: cognitive and clinical factors associated with memory efficiency and memory errors.

Science.gov (United States)

Brébion, Gildas; Bressan, Rodrigo A; Ohlsen, Ruth I; David, Anthony S

2013-12-01

Memory impairments in patients with schizophrenia have been associated with various cognitive and clinical factors. Hallucinations have been more specifically associated with errors stemming from source monitoring failure. We conducted a broad investigation of verbal memory and visual memory as well as source memory functioning in a sample of patients with schizophrenia. Various memory measures were tallied, and we studied their associations with processing speed, working memory span, and positive, negative, and depressive symptoms. Superficial and deep memory processes were differentially associated with processing speed, working memory span, avolition, depression, and attention disorders. Auditory/verbal and visual hallucinations were differentially associated with specific types of source memory error. We integrated all the results into a revised version of a previously published model of memory functioning in schizophrenia. The model describes the factors that affect memory efficiency, as well as the cognitive underpinnings of hallucinations within the source monitoring framework. © 2013.

Visual working memory buffers information retrieved from visual long-term memory.

Science.gov (United States)

Fukuda, Keisuke; Woodman, Geoffrey F

2017-05-16

Human memory is thought to consist of long-term storage and short-term storage mechanisms, the latter known as working memory. Although it has long been assumed that information retrieved from long-term memory is represented in working memory, we lack neural evidence for this and need neural measures that allow us to watch this retrieval into working memory unfold with high temporal resolution. Here, we show that human electrophysiology can be used to track information as it is brought back into working memory during retrieval from long-term memory. Specifically, we found that the retrieval of information from long-term memory was limited to just a few simple objects' worth of information at once, and elicited a pattern of neurophysiological activity similar to that observed when people encode new information into working memory. Our findings suggest that working memory is where information is buffered when being retrieved from long-term memory and reconcile current theories of memory retrieval with classic notions about the memory mechanisms involved.

Stress Effects on Working Memory, Explicit Memory, and Implicit Memory for Neutral and Emotional Stimuli in Healthy Men

OpenAIRE

Luethi, Mathias; Meier, Beat; Sandi, Carmen

2009-01-01

Stress is a strong modulator of memory function. However, memory is not a unitary process and stress seems to exert different effects depending on the memory type under study. Here, we explored the impact of social stress on different aspects of human memory, including tests for explicit memory and working memory (for neutral materials), as well as implicit memory (perceptual priming, contextual priming and classical conditioning for emotional stimuli). A total of 35 young adult...

Working memory capacity and controlled serial memory search.

Science.gov (United States)

Mızrak, Eda; Öztekin, Ilke

2016-08-01

The speed-accuracy trade-off (SAT) procedure was used to investigate the relationship between working memory capacity (WMC) and the dynamics of temporal order memory retrieval. High- and low-span participants (HSs, LSs) studied sequentially presented five-item lists, followed by two probes from the study list. Participants indicated the more recent probe. Overall, accuracy was higher for HSs compared to LSs. Crucially, in contrast to previous investigations that observed no impact of WMC on speed of access to item information in memory (e.g., Öztekin & McElree, 2010), recovery of temporal order memory was slower for LSs. While accessing an item's representation in memory can be direct, recovery of relational information such as temporal order information requires a more controlled serial memory search. Collectively, these data indicate that WMC effects are particularly prominent during high demands of cognitive control, such as serial search operations necessary to access temporal order information from memory. Copyright © 2016 Elsevier B.V. All rights reserved.

Discovery of two gravitationally lensed quasars with image separations of 3 arcseconds from the Sloan Digital Sky Survey

Energy Technology Data Exchange (ETDEWEB)

Oguri, Masamune; Inada, Naohisa; Hennawi, Joseph F.; Richards, Gordon T.; Johnston, David E.; Frieman, Joshua A.; Pindor, Bartosz; Strauss, Michael A.; Brunner, Robert; Becker, Robert H.; Castander, Francisco J.; Gregg, Michael D.; Hall, Patrick B.; Rix, Hans-Walter; Schneider, Donald P.; Bahcall, Neta A.; Brinkmann, Jonathan; York, Donald G.

2004-11-01

We report the discovery of two doubly-imaged quasars, SDSS J100128.61+502756.9 and SDSS J120629.65+433217.6, at redshifts of 1.838 and 1.789 and with image separations of 2.86'' and 2.90'', respectively. The objects were selected as lens candidates from the Sloan Digital Sky Survey (SDSS). Based on the identical nature of the spectra of the two quasars in each pair and the identification of the lens galaxies, we conclude that the objects are gravitational lenses. The lenses are complicated; in both systems there are several galaxies in the fields very close to the quasars, in addition to the lens galaxies themselves. The lens modeling implies that these nearby galaxies contribute significantly to the lens potentials. On larger scales, we have detected an enhancement in the galaxy density near SDSS J100128.61+502756.9. The number of lenses with image separation of {approx} 3'' in the SDSS already exceeds the prediction of simple theoretical models based on the standard Lambda-dominated cosmology and observed velocity function of galaxies.

THE PHYSICAL ORIGINS OF THE MORPHOLOGY-DENSITY RELATION: EVIDENCE FOR GAS STRIPPING FROM THE SLOAN DIGITAL SKY SURVEY

International Nuclear Information System (INIS)

Van der Wel, Arjen; Bell, Eric F.; Skibba, Ramin A.; Rix, Hans-Walter; Holden, Bradford P.

2010-01-01

We provide a physical interpretation and explanation of the morphology-density relation for galaxies, drawing on stellar masses, star formation rates, axis ratios, and group halo masses from the Sloan Digital Sky Survey. We first re-cast the classical morphology-density relation in more quantitative terms, using low star formation rate (quiescence) as a proxy for early-type morphology and dark matter halo mass from a group catalog as a proxy for environmental density: for galaxies of a given stellar mass the quiescent fraction is found to increase with increasing dark matter halo mass. Our novel result is that-at a given stellar mass-quiescent galaxies are significantly flatter in dense environments, implying a higher fraction of disk galaxies. Supposing that the denser environments differ simply by a higher incidence of quiescent disk galaxies that are structurally similar to star-forming disk galaxies of similar mass, explains simultaneously and quantitatively these quiescence-environment and shape-environment relations. Our findings add considerable weight to the slow removal of gas as the main physical driver of the morphology-density relation, at the expense of other explanations.

THE SLOAN DIGITAL SKY SURVEY REVERBERATION MAPPING PROJECT: RAPID C iv BROAD ABSORPTION LINE VARIABILITY

International Nuclear Information System (INIS)

Grier, C. J.; Brandt, W. N.; Trump, J. R.; Schneider, D. P.; Hall, P. B.; Shen, Yue; Vivek, M.; Dawson, K. S.; Ak, N. Filiz; Chen, Yuguang; Denney, K. D.; Kochanek, C. S.; Peterson, B. M.; Green, Paul J.; Jiang, Linhua; McGreer, Ian D.; Pâris, I.; Tao, Charling; Wood-Vasey, W. M.; Bizyaev, Dmitry

2015-01-01

We report the discovery of rapid variations of a high-velocity C iv broad absorption line trough in the quasar SDSS J141007.74+541203.3. This object was intensively observed in 2014 as a part of the Sloan Digital Sky Survey Reverberation Mapping Project, during which 32 epochs of spectroscopy were obtained with the Baryon Oscillation Spectroscopic Survey spectrograph. We observe significant (>4σ) variability in the equivalent width (EW) of the broad (∼4000 km s −1 wide) C iv trough on rest-frame timescales as short as 1.20 days (∼29 hr), the shortest broad absorption line variability timescale yet reported. The EW varied by ∼10% on these short timescales, and by about a factor of two over the duration of the campaign. We evaluate several potential causes of the variability, concluding that the most likely cause is a rapid response to changes in the incident ionizing continuum. If the outflow is at a radius where the recombination rate is higher than the ionization rate, the timescale of variability places a lower limit on the density of the absorbing gas of n e ≳ 3.9 × 10 5 cm −3 . The broad absorption line variability characteristics of this quasar are consistent with those observed in previous studies of quasars, indicating that such short-term variability may in fact be common and thus can be used to learn about outflow characteristics and contributions to quasar/host-galaxy feedback scenarios

A plausible (overlooked) super-luminous supernova in the Sloan digital sky survey stripe 82 data

International Nuclear Information System (INIS)

Kostrzewa-Rutkowska, Zuzanna; Kozłowski, Szymon; Wyrzykowski, Łukasz; Djorgovski, S. George; Mahabal, Ashish A.; Glikman, Eilat; Koposov, Sergey

2013-01-01

We present the discovery of a plausible super-luminous supernova (SLSN), found in the archival data of Sloan Digital Sky Survey (SDSS) Stripe 82, called PSN 000123+000504. The supernova (SN) peaked at m g < 19.4 mag in the second half of 2005 September, but was missed by the real-time SN hunt. The observed part of the light curve (17 epochs) showed that the rise to the maximum took over 30 days, while the decline time lasted at least 70 days (observed frame), closely resembling other SLSNe of SN 2007bi type. The spectrum of the host galaxy reveals a redshift of z = 0.281 and the distance modulus of μ = 40.77 mag. Combining this information with the SDSS photometry, we found the host galaxy to be an LMC-like irregular dwarf galaxy with an absolute magnitude of M B = –18.2 ± 0.2 mag and an oxygen abundance of 12+log [O/H]=8.3±0.2; hence, the SN peaked at M g < –21.3 mag. Our SLSN follows the relation for the most energetic/super-luminous SNe exploding in low-metallicity environments, but we found no clear evidence for SLSNe to explode in low-luminosity (dwarf) galaxies only. The available information on the PSN 000123+000504 light curve suggests the magnetar-powered model as a likely scenario of this event. This SLSN is a new addition to a quickly growing family of super-luminous SNe.

Memory blindness: Altered memory reports lead to distortion in eyewitness memory

OpenAIRE

Cochran, KJ; Greenspan, RL; Bogart, DF; Loftus, EF

2016-01-01

Choice blindness refers to the finding that people can often be misled about their own self-reported choices. However, little research has investigated the more long-term effects of choice blindness. We examined whether people would detect alterations to their own memory reports, and whether such alterations could influence participants' memories. Participants viewed slideshows depicting crimes, and then either reported their memories for episodic details of the event (Exp. 1) or identified a...

How Human Memory and Working Memory Work in Second Language Acquisition

OpenAIRE

小那覇, 洋子; Onaha, Hiroko

2014-01-01

We often draw an analogy between human memory and computers. Information around us is taken into our memory storage first, and then we use the information in storage whatever we need it in our daily life. Linguistic information is also in storage and we process our thoughts based on the memory that is stored. Memory storage consists of multiple memory systems; one of which is called working memory that includes short-term memory. Working memory is the central system that underpins the process...

Characterizing Memory Usage Behavior in Memory-related Code Changes

OpenAIRE

Wong, Howard Wah

2017-01-01

With the heavy memory pressure produced by multi-core systems and with memory per- formance trailing processor performance, today’s application developers need to consider the memory subsystem during software development. In particular, optimizing software re- quires a deep understanding of how the software uses the memory and how the hardware satisfies the memory requests. In order to accelerate development, programmers rely on soft- ware tools such as profilers for insightful analysis. Howe...

The Discovery of a High-Redshift Quasar without Emission Lines from Sloan Digital Sky Survey Commissioning Data.

Science.gov (United States)

Fan; Strauss; Gunn; Lupton; Carilli; Rupen; Schmidt; Moustakas; Davis; Annis; Bahcall; Brinkmann; Brunner; Csabai; Doi; Fukugita; Heckman; Hennessy; Hindsley; Ivezic; Knapp; Lamb; Munn; Pauls; Pier; Rockosi; Schneider; Szalay; Tucker; York

1999-12-01

We report observations of a luminous unresolved object at redshift z=4.62, with a featureless optical spectrum redward of the Lyalpha forest region, discovered from Sloan Digital Sky Survey commissioning data. The redshift is determined by the onset of the Lyalpha forest at lambda approximately 6800 Å and a Lyman limit system at lambda=5120 Å. A strong Lyalpha absorption system with weak metal absorption lines at z=4.58 is also identified in the spectrum. The object has a continuum absolute magnitude of -26.6 at 1450 Å in the rest frame (h0=0.5, q0=0.5) and therefore cannot be an ordinary galaxy. It shows no radio emission (the 3 sigma upper limit of its flux at 6 cm is 60 µJy), indicating a radio-to-optical flux ratio at least as small as that of the radio-weakest BL Lacertae objects known. It is also not linearly polarized to a 3 sigma upper limit of 4% in the observed I band. Therefore, it is either the most distant BL Lac object known to date, with very weak radio emission, or a new type of unbeamed quasar, whose broad emission line region is very weak or absent.

M DWARFS IN SLOAN DIGITAL SKY SURVEY STRIPE 82: PHOTOMETRIC LIGHT CURVES AND FLARE RATE ANALYSIS

International Nuclear Information System (INIS)

Kowalski, Adam F.; Hawley, Suzanne L.; Hilton, Eric J.; Becker, Andrew C.; Sesar, Branimir; West, Andrew A.; Bochanski, John J.

2009-01-01

We present a flare rate analysis of 50,130 M dwarf light curves in Sloan Digital Sky Survey Stripe 82. We identified 271 flares using a customized variability index to search ∼2.5 million photometric observations for flux increases in the u and g bands. Every image of a flaring observation was examined by eye and with a point-spread function-matching and image subtraction tool to guard against false positives. Flaring is found to be strongly correlated with the appearance of Hα in emission in the quiet spectrum. Of the 99 flare stars that have spectra, we classify eight as relatively inactive. The flaring fraction is found to increase strongly in stars with redder colors during quiescence, which can be attributed to the increasing flare visibility and increasing active fraction for redder stars. The flaring fraction is strongly correlated with |Z| distance such that most stars that flare are within 300 pc of the Galactic plane. We derive flare u-band luminosities and find that the most luminous flares occur on the earlier-type m dwarfs. Our best estimate of the lower limit on the flaring rate (averaged over Stripe 82) for flares with Δu ≥ 0.7 mag on stars with u -1 deg -2 but can vary significantly with the line of sight.

THE SLOAN DIGITAL SKY SURVEY DATA RELEASE 7 SPECTROSCOPIC M DWARF CATALOG. II. STATISTICAL PARALLAX ANALYSIS

International Nuclear Information System (INIS)

Bochanski, John J.; Hawley, Suzanne L.; West, Andrew A.

2011-01-01

We present a statistical parallax analysis of low-mass dwarfs from the Sloan Digital Sky Survey. We calculate absolute r-band magnitudes (M r ) as a function of color and spectral type and investigate changes in M r with location in the Milky Way. We find that magnetically active M dwarfs are intrinsically brighter in M r than their inactive counterparts at the same color or spectral type. Metallicity, as traced by the proxy ζ, also affects M r , with metal-poor stars having fainter absolute magnitudes than higher metallicity M dwarfs at the same color or spectral type. Additionally, we measure the velocity ellipsoid and solar reflex motion for each subsample of M dwarfs. We find good agreement between our measured solar peculiar motion and previous results for similar populations, as well as some evidence for differing motions of early and late M-type populations in U and W velocities that cannot be attributed to asymmetric drift. The reflex solar motion and the velocity dispersions both show that younger populations, as traced by magnetic activity and location near the Galactic plane, have experienced less dynamical heating. We introduce a new parameter, the independent position altitude (IPA), to investigate populations as a function of vertical height from the Galactic plane. M dwarfs at all types exhibit an increase in velocity dispersion when analyzed in comparable IPA subgroups.

The cortical basis of true memory and false memory for motion.

Science.gov (United States)

Karanian, Jessica M; Slotnick, Scott D

2014-02-01

Behavioral evidence indicates that false memory, like true memory, can be rich in sensory detail. By contrast, there is fMRI evidence that true memory for visual information produces greater activity in earlier visual regions than false memory, which suggests true memory is associated with greater sensory detail. However, false memory in previous fMRI paradigms may have lacked sufficient sensory detail to recruit earlier visual processing regions. To investigate this possibility in the present fMRI study, we employed a paradigm that produced feature-specific false memory with a high degree of visual detail. During the encoding phase, moving or stationary abstract shapes were presented to the left or right of fixation. During the retrieval phase, shapes from encoding were presented at fixation and participants classified each item as previously "moving" or "stationary" within each visual field. Consistent with previous fMRI findings, true memory but not false memory for motion activated motion processing region MT+, while both true memory and false memory activated later cortical processing regions. In addition, false memory but not true memory for motion activated language processing regions. The present findings indicate that true memory activates earlier visual regions to a greater degree than false memory, even under conditions of detailed retrieval. Thus, the dissociation between previous behavioral findings and fMRI findings do not appear to be task dependent. Future work will be needed to assess whether the same pattern of true memory and false memory activity is observed for different sensory modalities. Copyright © 2013 Elsevier Ltd. All rights reserved.

SPECTROSCOPIC ORBITAL PERIODS FOR 29 CATACLYSMIC VARIABLES FROM THE SLOAN DIGITAL SKY SURVEY

Energy Technology Data Exchange (ETDEWEB)

Thorstensen, John R.; Taylor, Cynthia J.; Peters, Christopher S.; Skinner, Julie N. [Department of Physics and Astronomy 6127 Wilder Laboratory, Dartmouth College Hanover, NH 03755-3528 (United States); Southworth, John [Astrophysics Group Keele University Staffordshire ST5 5BG (United Kingdom); Gänsicke, Boris T. [Department of Physics University of Warwick Coventry CV4 7AL (United Kingdom)

2015-04-15

We report follow-up spectroscopy of 29 cataclysmic variables from the Sloan Digital Sky Survey (SDSS), 22 of which were discovered by SDSS and seven of which are previously known systems that were recovered in SDSS. The periods for 16 of these objects were included in the tabulation by Gänsicke et al. While most of the systems have periods less than 2 hr, only one has a period in the 80–86 minutes “spike” found by Gänsicke et al., and 11 have periods longer than 3 hr, indicating that the present sample is skewed toward longer-period, higher-luminosity objects. Seven of the objects have spectra resembling dwarf novae, but have apparently never been observed in outburst, suggesting that many cataclysmics with relatively low variability amplitude remain to be discovered. Some of the objects are notable. SDSS J07568+0858 and SDSS J08129+1911 were previously known to have deep eclipses; in addition to spectroscopy, we use archival data from the Catalina Real Time Transient Survey to refine their periods. We give a parallax-based distance of 195 (+54, −39) pc for LV Cnc (SDSS J09197+0857), which at P{sub orb} = 81 m has the shortest orbital period in our sample. SDSS J08091+3814 shows both the spectroscopic phase offset and phase-dependent absorption found in SW Sextantis stars. The average spectra of SDSS J08055+0720 and SDSS J16191+1351 show contributions from K-type secondaries, and SDSS J080440+0239 shows a contribution from an early M star. We use these to constrain the distances. SDSS J09459+2922 has characteristics typical of a magnetic system. SDSS11324+6249 may be a novalike variable, and if so, its orbital period (99 minutes) is unusually short for that subclass.

SYSTEMATIC SEARCH FOR EXTREMELY METAL-POOR GALAXIES IN THE SLOAN DIGITAL SKY SURVEY

Energy Technology Data Exchange (ETDEWEB)

Morales-Luis, A. B.; Sanchez Almeida, J.; Aguerri, J. A. L.; Munoz-Tunon, C., E-mail: abml@iac.es, E-mail: jos@iac.es, E-mail: cmt@iac.es, E-mail: jalfonso@iac.es [Instituto de Astrofisica de Canarias, E-38205 La Laguna, Tenerife (Spain)

2011-12-10

We carry out a systematic search for extremely metal-poor (XMP) galaxies in the spectroscopic sample of Sloan Digital Sky Survey (SDSS) data release 7 (DR7). The XMP candidates are found by classifying all the galaxies according to the form of their spectra in a region 80 A wide around H{alpha}. Due to the data size, the method requires an automatic classification algorithm. We use k-means. Our systematic search renders 32 galaxies having negligible [N II] lines, as expected in XMP galaxy spectra. Twenty-one of them have been previously identified as XMP galaxies in the literature-the remaining 11 are new. This was established after a thorough bibliographic search that yielded only some 130 galaxies known to have an oxygen metallicity 10 times smaller than the Sun (explicitly, with 12 + log (O/H) {<=} 7.65). XMP galaxies are rare; they represent 0.01% of the galaxies with emission lines in SDSS/DR7. Although the final metallicity estimate of all candidates remains pending, strong-line empirical calibrations indicate a metallicity about one-tenth solar, with the oxygen metallicity of the 21 known targets being 12 + log (O/H) {approx_equal} 7.61 {+-} 0.19. Since the SDSS catalog is limited in apparent magnitude, we have been able to estimate the volume number density of XMP galaxies in the local universe, which turns out to be (1.32 {+-} 0.23) Multiplication-Sign 10{sup -4} Mpc{sup -3}. The XMP galaxies constitute 0.1% of the galaxies in the local volume, or {approx}0.2% considering only emission-line galaxies. All but four of our candidates are blue compact dwarf galaxies, and 24 of them have either cometary shape or are formed by chained knots.

Aging accelerates memory extinction and impairs memory restoration in Drosophila.

Science.gov (United States)

Chen, Nannan; Guo, Aike; Li, Yan

2015-05-15

Age-related memory impairment (AMI) is a phenomenon observed from invertebrates to human. Memory extinction is proposed to be an active inhibitory modification of memory, however, whether extinction is affected in aging animals remains to be elucidated. Employing a modified paradigm for studying memory extinction in fruit flies, we found that only the stable, but not the labile memory component was suppressed by extinction, thus effectively resulting in higher memory loss in aging flies. Strikingly, young flies were able to fully restore the stable memory component 3 h post extinction, while aging flies failed to do so. In conclusion, our findings reveal that both accelerated extinction and impaired restoration contribute to memory impairment in aging animals. Copyright © 2015 Elsevier Inc. All rights reserved.

Disputed Memory

DEFF Research Database (Denmark)

, individual and political discourse and electronic social media. Analyzing memory disputes in various local, national and transnational contexts, the chapters demonstrate the political power and social impact of painful and disputed memories. The book brings new insights into current memory disputes...... in Central, Eastern and Southeastern Europe. It contributes to the understanding of processes of memory transmission and negotiation across borders and cultures in Europe, emphasizing the interconnectedness of memory with emotions, mediation and politics....... century in the region. Written by an international group of scholars from a diversity of disciplines, the chapters approach memory disputes in methodologically innovative ways, studying representations and negotiations of disputed pasts in different media, including monuments, museum exhibitions...

Working memory predicts the rejection of false memories.

Science.gov (United States)

Leding, Juliana K

2012-01-01

The relationship between working memory capacity (WMC) and false memories in the memory conjunction paradigm was explored. Previous research using other paradigms has shown that individuals high in WMC are not as likely to experience false memories as low-WMC individuals, the explanation being that high-WMC individuals are better able to engage in source monitoring. In the memory conjunction paradigm participants are presented at study with parent words (e.g., eyeglasses, whiplash). At test, in addition to being presented with targets and foils, participants are presented with lures that are composed of previously studied features (e.g., eyelash). It was found that high-WMC individuals had lower levels of false recognition than low-WMC individuals. Furthermore, recall-to-reject responses were analysed (e.g., "I know I didn't see eyelash because I remember seeing eyeglasses") and it was found that high-WMC individuals were more likely to utilise this memory editing strategy, providing direct evidence that one reason that high-WMC individuals are not as prone to false memories is because they are better able to engage in source monitoring.

THE MILKY WAY TOMOGRAPHY WITH SLOAN DIGITAL SKY SURVEY. IV. DISSECTING DUST

International Nuclear Information System (INIS)

Berry, Michael; Ivezić, Željko; Brooks, Keira J.; Gibson, Robert R.; Jones, Lynne; Yoachim, Peter; Krughoff, Simon; Connolly, Andrew J.; Loebman, Sarah; Sesar, Branimir; Jurić, Mario; Schlafly, Edward F.; Finkbeiner, Douglas; Bellovary, Jillian; Vrbanec, Dijana; Beers, Timothy C.; Schneider, Donald P.; Kimball, Amy; Bond, Nicholas A.; Schlegel, David

2012-01-01

We use Sloan Digital Sky Survey (SDSS) photometry of 73 million stars to simultaneously constrain best-fit main-sequence stellar spectral energy distribution (SED) and amount of dust extinction along the line of sight toward each star. Using a subsample of 23 million stars with Two Micron All Sky Survey (2MASS) photometry, whose addition enables more robust results, we show that SDSS photometry alone is sufficient to break degeneracies between intrinsic stellar color and dust amount when the shape of extinction curve is fixed. When using both SDSS and 2MASS photometry, the ratio of the total to selective absorption, R V , can be determined with an uncertainty of about 0.1 for most stars in high-extinction regions. These fits enable detailed studies of the dust properties and its spatial distribution, and of the stellar spatial distribution at low Galactic latitudes (|b| V = 3.0 ± 0.1(random)±0.1 (systematic) over most of the high-latitude sky. At low Galactic latitudes (|b| V and find that R V = 3.1 cannot be ruled out in any of the 10 SEGUE stripes at a precision level of ∼0.1-0.2. Our best estimate for the intrinsic scatter of R V in the regions probed by SEGUE stripes is ∼0.2. We introduce a method for efficient selection of candidate red giant stars in the disk, dubbed 'dusty parallax relation', which utilizes a correlation between distance and the extinction along the line of sight. We make these best-fit parameters, as well as all the input SDSS and 2MASS data, publicly available in a user-friendly format. These data can be used for studies of stellar number density distribution, the distribution of dust properties, for selecting sources whose SED differs from SEDs for high-latitude main-sequence stars, and for estimating distances to dust clouds and, in turn, to molecular gas clouds.

A hot white dwarf luminosity function from the Sloan Digital Sky Survey

Science.gov (United States)

Krzesinski, J.; Kleinman, S. J.; Nitta, A.; Hügelmeyer, S.; Dreizler, S.; Liebert, J.; Harris, H.

2009-12-01

Aims. We present a hot white dwarf (WD) luminosity function (LF) using data taken from the Sloan Digital Sky Survey (SDSS) Data Release 4. We present and discuss a combined LF, along with separate DA and non-DA as LFs. We explore the completeness of our LFs and interpret a sudden drop in the non-DA LF near 2 M_bol as a transition of the non-DA WD atmosphere into the DA one during WD evolution. Our LF extends roughly between -0.5 T_eff > ˜25 000 K. Our LF should now be useful for estimates of recent star formation and for studies of neutrino and other potential particle emission losses in hot WDs. Methods: To create a sample whose completeness can be characterized fully, we used stars whose spectra were obtained via the SDSS's “hot standard” target selection criteria. The hot standard stars were purposefully targeted to a high level of completeness by the SDSS for calibration purposes. We are fortunate that many of them are hot white dwarfs stars. We further limited the sample to stars with fitted temperatures exceeding 23 500 K and log{g} > 7.0. We determined stellar distances for our sample based on their absolute SDSS g filter magnitudes, derived from WD stellar atmosphere model fits to the SDSS stellar spectra. Results: We compared our LF with those of other researchers where overlap occurs; however, our LFs are unique in their extension to the most luminous/hottest WDs. The cool end of our LF connects with the hot end of previously determined SDSS WD LFs and agreement here is quite good. It is also good with previous non-SDSS WD LFs. We note distinct differences between the DA and non-DA LFs and discuss the reliability of the DA LF at its hot end. We have extended the range of luminosities covered in the most recent WD LFs. The SDSS sample is understood quite well and its exploration should contribute to a number of new insights into early white dwarf evolution.

Cognitive Impairment Associated with Cancer

Science.gov (United States)

Pendergrass, J. Cara; Harrison, John E.

2018-01-01

This brief review explores the areas of cognitive impairment that have been observed in cancer patients and survivors, the cognitive assessment tools used, and the management of the observed cognitive changes. Cognitive changes and impairment observed in patients with cancer and those in remission can be related to the direct effects of cancer itself, nonspecific factors or comorbid conditions that are independent of the actual disease, and/or the treatments or combination of treatments administered. Attention, memory, and executive functioning are the most frequently identified cognitive domains impacted by cancer. However, the prevalence and extent of impairment remains largely unknown due to marked differences in methodology, definitions of cognitive impairment, and the assessment measures used. Assessment of cognitive functioning is an important and necessary part of a comprehensive oncological care plan. Research is needed to establish a better understanding of cognitive changes and impairments associated with cancer so that optimal patient outcomes can be achieved. PMID:29497579

Detailed Sensory Memory, Sloppy Working Memory

OpenAIRE

Sligte, Ilja G.; Vandenbroucke, Annelinde R. E.; Scholte, H. Steven; Lamme, Victor A. F.

2010-01-01

Visual short-term memory (VSTM) enables us to actively maintain information in mind for a brief period of time after stimulus disappearance. According to recent studies, VSTM consists of three stages - iconic memory, fragile VSTM, and visual working memory - with increasingly stricter capacity limits and progressively longer lifetimes. Still, the resolution (or amount of visual detail) of each VSTM stage has remained unexplored and we test this in the present study. We presented people with a...

Memory skills mediating superior memory in a world-class memorist.

Science.gov (United States)

Ericsson, K Anders; Cheng, Xiaojun; Pan, Yafeng; Ku, Yixuan; Ge, Yi; Hu, Yi

2017-10-01

Laboratory studies have investigated how individuals with normal memory spans attained digit spans over 80 digits after hundreds of hours of practice. Experimental analyses of their memory skills suggested that their attained memory spans were constrained by the encoding time, for the time needed will increase if the length of digit sequences to be memorised becomes longer. These constraints seemed to be violated by a world-class memorist, Feng Wang (FW), who won the World Memory Championship by recalling 300 digits presented at 1 digit/s. In several studies we examined FW's memory skills underlying his exceptional performance. First FW reproduced his superior memory span of 200 digits under laboratory condition, and we obtained his retrospective reports describing his encoding/retrieval processes (Experiment 1). Further experiments used self-paced memorisation to identify temporal characteristics of encoding of digits in 4-digit clusters (Experiment 2), and explored memory encoding at presentation speeds much faster than 1 digit/s (Experiment 3). FW's superiority over previous digit span experts is explained by his acquisition of well-known mnemonic techniques and his training that focused on rapid memorisation. His memory performance supports the feasibility of acquiring memory skills for improved working memory based on storage in long-term memory.

Embodied memory: unconscious smiling modulates emotional evaluation of episodic memories

KAUST Repository

Arminjon, Mathieu

2015-05-26

Since Damasio introduced the somatic markers hypothesis in Damasio (1994), it has spread through the psychological community, where it is now commonly acknowledged that somatic states are a factor in producing the qualitative dimension of our experiences. Present actions are emotionally guided by those somatic states that were previously activated in similar experiences. In this model, somatic markers serve as a kind of embodied memory. Here, we test whether the manipulation of somatic markers can modulate the emotional evaluation of negative memories. Because facial feedback has been shown to be a powerful means of modifying emotional judgements, we used it to manipulate somatic markers. Participants first read a sad story in order to induce a negative emotional memory and then were asked to rate their emotions and memory about the text. Twenty-four hours later, the same participants were asked to assume a predetermined facial feedback (smiling) while reactivating their memory of the sad story. The participants were once again asked to fill in emotional and memory questionnaires about the text. Our results showed that participants who had smiled during memory reactivation later rated the text less negatively than control participants. However, the contraction of the zygomaticus muscles during memory reactivation did not have any impact on episodic memory scores. This suggests that manipulating somatic states modified emotional memory without affecting episodic memory. Thus, modulating memories through bodily states might pave the way to studying memory as an embodied function and help shape new kinds of psychotherapeutic interventions.

Memories of Parent Behaviors and Adult Attachment in Childhood Cancer Survivors

NARCIS (Netherlands)

Lehmann, Vicky; Hagedoorn, Mariët; Gerhardt, Cynthia A; Keim, Madelaine C; Guthrie, Lory; Sanderman, Robbert; Tuinman, Marrit A

PURPOSE: Childhood cancer is stressful for the entire family. Preoccupation and anxiety surrounding the child's illness may result in parents of children with cancer being overprotective or less emotionally responsive toward their children. Such parenting in response to a negative life event like

Nanographene charge trapping memory with a large memory window

International Nuclear Information System (INIS)

Meng, Jianling; Yang, Rong; Zhao, Jing; He, Congli; Wang, Guole; Shi, Dongxia; Zhang, Guangyu

2015-01-01

Nanographene is a promising alternative to metal nanoparticles or semiconductor nanocrystals for charge trapping memory. In general, a high density of nanographene is required in order to achieve high charge trapping capacity. Here, we demonstrate a strategy of fabrication for a high density of nanographene for charge trapping memory with a large memory window. The fabrication includes two steps: (1) direct growth of continuous nanographene film; and (2) isolation of the as-grown film into high-density nanographene by plasma etching. Compared with directly grown isolated nanographene islands, abundant defects and edges are formed in nanographene under argon or oxygen plasma etching, i.e. more isolated nanographene islands are obtained, which provides more charge trapping sites. As-fabricated nanographene charge trapping memory shows outstanding memory properties with a memory window as wide as ∼9 V at a relative low sweep voltage of ±8 V, program/erase speed of ∼1 ms and robust endurance of >1000 cycles. The high-density nanographene charge trapping memory provides an outstanding alternative for downscaling technology beyond the current flash memory. (paper)

Aging memories: differential decay of episodic memory components

NARCIS (Netherlands)

Talamini, L.M.; Gorree, E.

2012-01-01

Some memories about events can persist for decades, even a lifetime. However, recent memories incorporate rich sensory information, including knowledge on the spatial and temporal ordering of event features, while old memories typically lack this "filmic" quality. We suggest that this apparent

Nanoscale memory devices

International Nuclear Information System (INIS)

Chung, Andy; Deen, Jamal; Lee, Jeong-Soo; Meyyappan, M

2010-01-01

This article reviews the current status and future prospects for the use of nanomaterials and devices in memory technology. First, the status and continuing scaling trends of the flash memory are discussed. Then, a detailed discussion on technologies trying to replace flash in the near-term is provided. This includes phase change random access memory, Fe random access memory and magnetic random access memory. The long-term nanotechnology prospects for memory devices include carbon-nanotube-based memory, molecular electronics and memristors based on resistive materials such as TiO 2 . (topical review)

THE SLOAN GREAT WALL. MORPHOLOGY AND GALAXY CONTENT

International Nuclear Information System (INIS)

Einasto, M.; Liivamaegi, L. J.; Tempel, E.; Saar, E.; Tago, E.; Einasto, P.; Enkvist, I.; Einasto, J.; MartInez, V. J.; Heinaemaeki, P.; Nurmi, P.

2011-01-01

We present the results of a study of the morphology and galaxy content of the Sloan Great Wall (SGW), the richest galaxy system in the nearby universe. We use the luminosity density field to determine superclusters in the SGW, and the fourth Minkowski functional V 3 and the morphological signature (the K 1 -K 2 shapefinder curve) to show the different morphologies of the SGW, from a single filament to a multibranching, clumpy planar system. We show that the richest supercluster in the SGW, SCl 126, and especially its core, resembles a very rich filament, while another rich supercluster in the SGW, SCl 111, resembles a 'multispider'-an assembly of high-density regions connected by chains of galaxies. We study the substructure of individual galaxy populations determined by their color in these superclusters using Minkowski functionals and find that in the high-density core of the SGW the clumpiness of red and blue galaxies is similar, but in the outskirts of superclusters the distribution of red galaxies is clumpier than that of blue galaxies. At intermediate densities, the systems of blue galaxies have tunnels through them. We assess the statistical significance of our results using the halo model and smoothed bootstrap. We study the galaxy content and the properties of groups of galaxies in the two richest superclusters of the SGW, paying special attention to bright red galaxies (BRGs) and the first ranked (the most luminous) galaxies in SGW groups. The BRGs are the nearby luminous red galaxies; they are mostly bright and red and typically reside in groups (several groups host five or more BRGs). About one-third of the BRGs are spirals. The scatter of colors of elliptical BRGs is smaller than that of spiral BRGs. About half of the BRGs and of first ranked galaxies in groups have large peculiar velocities. Groups with elliptical BRGs as their first ranked galaxies populate superclusters more uniformly than the groups that have a spiral BRG as their first ranked

Associative working memory and subsequent episodic memory in Alzheimer's disease.

NARCIS (Netherlands)

Geldorp, B. van; Konings, E.P.; Tilborg, I.A. Van; Kessels, R.P.C.

2012-01-01

Recent studies indicate deficits in associative working memory in patients with medial-temporal lobe amnesia. However, it is unclear whether these deficits reflect working memory processing or are due to hippocampally mediated long-term memory impairment. We investigated associative working memory

Associative working memory and subsequent episodic memory in Alzheimer's disease

NARCIS (Netherlands)

Geldorp, B. van; Konings, E.P.C.; Tilborg, I.A.D.A. van; Kessels, R.P.C.

2012-01-01

Recent studies indicate deficits in associative working memory in patients with medial-temporal lobe amnesia. However, it is unclear whether these deficits reflect working memory processing or are due to hippocampally mediated long-term memory impairment. We investigated associative working memory

The Sloan Digital Sky Survey Reverberation Mapping Project: Composite Lags at z ≤ 1

Science.gov (United States)

Li, Jennifer; Shen, Yue; Horne, Keith; Brandt, W. N.; Greene, Jenny E.; Grier, C. J.; Ho, Luis C.; Kochanek, Chris; Schneider, Donald P.; Trump, Jonathan R.; Dawson, Kyle S.; Pan, Kaike; Bizyaev, Dmitry; Oravetz, Daniel; Simmons, Audrey; Malanushenko, Elena

2017-09-01

We present composite broad-line region (BLR) reverberation mapping lag measurements for Hα, Hβ, He II λ4686, and Mg II for a sample of 144, z ≲ 1 quasars from the Sloan Digital Sky Survey Reverberation Mapping (SDSS-RM) project. Using only the 32-epoch spectroscopic light curves in the first six-month season of SDSS-RM observations, we compile correlation function measurements for individual objects and then coadd them to allow the measurement of the average lags for our sample at mean redshifts of 0.4 (for Hα) and ˜0.65 (for the other lines). At similar quasar luminosities and redshifts, the sample-averaged lag decreases in the order of Mg II, Hα, Hβ, and He II. This decrease in lags is accompanied by an increase in the mean line width of the four lines, and is roughly consistent with the virialized motion for BLR gas in photoionization equilibrium. These are among the first RM measurements of stratified BLR structure at z > 0.3. Dividing our sample by luminosity, Hα shows clear evidence of increasing lags with luminosity, consistent with the expectation from the measured BLR size-luminosity relation based on Hβ. The other three lines do not show a clear luminosity trend in their average lags due to the limited dynamic range of luminosity probed and the poor average correlation signals in the divided samples, a situation that will be improved with the incorporation of additional photometric and spectroscopic data from SDSS-RM. We discuss the utility and caveats of composite lag measurements for large statistical quasar samples with reverberation mapping data.

The Sloan Digital Sky Survey Reverberation Mapping Project: Composite Lags at z ≤ 1

Energy Technology Data Exchange (ETDEWEB)

Li, Jennifer; Shen, Yue [Department of Astronomy, University of Illinois at Urbana-Champaign, Urbana, IL 61801 (United States); Horne, Keith [SUPA Physics/Astronomy, Univ. of St. Andrews, St. Andrews KY16 9SS (United Kingdom); Brandt, W. N.; Grier, C. J.; Schneider, Donald P. [Department of Astronomy and Astrophysics, The Pennsylvania State University, University Park, PA, 16802 (United States); Greene, Jenny E. [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Ho, Luis C. [Kavli Institute for Astronomy and Astrophysics, Peking University, Beijing 100871 (China); Kochanek, Chris [Department of Astronomy, The Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States); Trump, Jonathan R. [Department of Physics, University of Connecticut, 2152 Hillside Road, Unit 3046, Storrs, CT 06269 (United States); Dawson, Kyle S. [Department of Physics and Astronomy, University of Utah, Salt Lake City, UT 84112 (United States); Pan, Kaike; Bizyaev, Dmitry; Oravetz, Daniel; Simmons, Audrey; Malanushenko, Elena [Apache Point Observatory and New Mexico State University, P.O. Box 59, Sunspot, NM, 88349-0059 (United States)

2017-09-01

We present composite broad-line region (BLR) reverberation mapping lag measurements for H α , H β , He ii λ 4686, and Mg ii for a sample of 144, z ≲ 1 quasars from the Sloan Digital Sky Survey Reverberation Mapping (SDSS-RM) project. Using only the 32-epoch spectroscopic light curves in the first six-month season of SDSS-RM observations, we compile correlation function measurements for individual objects and then coadd them to allow the measurement of the average lags for our sample at mean redshifts of 0.4 (for H α ) and ∼0.65 (for the other lines). At similar quasar luminosities and redshifts, the sample-averaged lag decreases in the order of Mg ii, H α , H β , and He ii. This decrease in lags is accompanied by an increase in the mean line width of the four lines, and is roughly consistent with the virialized motion for BLR gas in photoionization equilibrium. These are among the first RM measurements of stratified BLR structure at z > 0.3. Dividing our sample by luminosity, H α shows clear evidence of increasing lags with luminosity, consistent with the expectation from the measured BLR size–luminosity relation based on H β . The other three lines do not show a clear luminosity trend in their average lags due to the limited dynamic range of luminosity probed and the poor average correlation signals in the divided samples, a situation that will be improved with the incorporation of additional photometric and spectroscopic data from SDSS-RM. We discuss the utility and caveats of composite lag measurements for large statistical quasar samples with reverberation mapping data.

Investigations of Short-Timescale Outflow Variability in Quasars of the Sloan Digital Sky Survey

Science.gov (United States)

Hemler, Zachary; Grier, Catherine; Brandt, William; Hall, Patrick; Schneider, Donald; Shen, Yue; Fernandez-Trincado, Jose; SDSS-RM Collaboration

2018-01-01

Quasar outflows are hypothesized to regulate the growth of a quasar's host galaxy and the supermassive black hole (SMBH) itself. Thus, understanding the physics of these outflows is imperative to understanding galactic evolution. The physical properties of these outflows, such as density, radial distance from the SMBH, and kinetic energy can be investigated by measuring both the strength and shape variability of broad absorption lines (BALs) in quasar spectra. However, the accuracy of physical properties calculated using BAL variability methods is limited by the time resolution of the observations. Recent spectral data from the Sloan Digital Sky Survey Reverberation Mapping program (SDSS-RM) provides a novel opportunity to investigate the short-term BAL variability of many quasars at many epochs. The SDSS-RM program took many epochs of spectra for a large sample of quasars over a period of several years, many of which exhibit BALs. The median rest-frame time resolution of these observations is roughly 2 days, in contrast to previous large-sample studies, which typically have time spacing on the order of hundred of days. We are using the SDSS-RM dataset to conduct a BAL variability study that will further constrain outflow properties and provide significant insights into the variability mechanisms of quasar outflows. We are searching for variability in BALs on timescales of less than 2 days among our sample of 22 quasars and determining whether this behavior is common among quasars. We are also investigating the general short-term (less than 10 days) variability characteristics of the entire sample. We will present preliminary results from this study and the possible implications to our understanding of quasar outflows.

Extreme Variability Quasars from the Sloan Digital Sky Survey and the Dark Energy Survey

Science.gov (United States)

Rumbaugh, N.; Shen, Yue; Morganson, Eric; Liu, Xin; Banerji, M.; McMahon, R. G.; Abdalla, F. B.; Benoit-Lévy, A.; Bertin, E.; Brooks, D.; Buckley-Geer, E.; Capozzi, D.; Carnero Rosell, A.; Carrasco Kind, M.; Carretero, J.; Cunha, C. E.; D’Andrea, C. B.; da Costa, L. N.; DePoy, D. L.; Desai, S.; Doel, P.; Frieman, J.; García-Bellido, J.; Gruen, D.; Gruendl, R. A.; Gschwend, J.; Gutierrez, G.; Honscheid, K.; James, D. J.; Kuehn, K.; Kuhlmann, S.; Kuropatkin, N.; Lima, M.; Maia, M. A. G.; Marshall, J. L.; Martini, P.; Menanteau, F.; Plazas, A. A.; Reil, K.; Roodman, A.; Sanchez, E.; Scarpine, V.; Schindler, R.; Schubnell, M.; Sheldon, E.; Smith, M.; Soares-Santos, M.; Sobreira, F.; Suchyta, E.; Swanson, M. E. C.; Walker, A. R.; Wester, W.; (DES Collaboration

2018-02-01

We perform a systematic search for long-term extreme variability quasars (EVQs) in the overlapping Sloan Digital Sky Survey and 3 Year Dark Energy Survey imaging, which provide light curves spanning more than 15 years. We identified ∼1000 EVQs with a maximum change in g-band magnitude of more than 1 mag over this period, about 10% of all quasars searched. The EVQs have L bol ∼ 1045–1047 erg s‑1 and L/L Edd ∼ 0.01–1. Accounting for selection effects, we estimate an intrinsic EVQ fraction of ∼30%–50% among all g≲ 22 quasars over a baseline of ∼15 yr. We performed detailed multi-wavelength, spectral, and variability analyses for the EVQs and compared them to their parent quasar sample. We found that EVQs are distinct from a control sample of quasars matched in redshift and optical luminosity: (1) their UV broad emission lines have larger equivalent widths; (2) their Eddington ratios are systematically lower; and (3) they are more variable on all timescales. The intrinsic difference in quasar properties for EVQs suggests that internal processes associated with accretion are the main driver for the observed extreme long-term variability. However, despite their different properties, EVQs seem to be in the tail of a continuous distribution of quasar properties, rather than standing out as a distinct population. We speculate that EVQs are normal quasars accreting at relatively low rates, where the accretion flow is more likely to experience instabilities that drive the changes in flux by a factor of a few on multi-year timescales.

THE SLOAN BRIGHT ARCS SURVEY: TEN STRONG GRAVITATIONAL LENSING CLUSTERS AND EVIDENCE OF OVERCONCENTRATION

Energy Technology Data Exchange (ETDEWEB)

Wiesner, Matthew P. [Department of Physics, Northern Illinois University, DeKalb, IL 60115 (United States); Lin, Huan; Allam, Sahar S.; Annis, James; Buckley-Geer, Elizabeth J.; Diehl, H. Thomas; Kubik, Donna; Kubo, Jeffrey M.; Tucker, Douglas [Center for Particle Astrophysics, Fermi National Accelerator Laboratory, P.O. Box 500, Batavia, IL 60510 (United States)

2012-12-10

We describe 10 strong lensing galaxy clusters of redshift 0.26 {<=} z {<=} 0.56 that were found in the Sloan Digital Sky Survey. We present measurements of richness (N{sub 200}), mass (M{sub 200}), and velocity dispersion for the clusters. We find that in order to use the mass-richness relation from Johnston et al., which was established at mean redshift of 0.25, it is necessary to scale measured richness values up by 1.47. Using this scaling, we find richness values for these clusters to be in the range of 22 {<=} N{sub 200} {<=} 317 and mass values to be in the range of 1 Multiplication-Sign 10{sup 14} h {sup -1} M{sub Sun} {<=} M{sub 200} {<=} 30 Multiplication-Sign 10{sup 14} h {sup -1} M{sub Sun }. We also present measurements of Einstein radius, mass, and velocity dispersion for the lensing systems. The Einstein radii ({theta}{sub E}) are all relatively small, with 5.''4 {<=} {theta}{sub E} {<=} 13''. Finally, we consider if there is evidence that our clusters are more concentrated than {Lambda}CDM would predict. We find that six of our clusters do not show evidence of overconcentration, while four of our clusters do. We note a correlation between overconcentration and mass, as the four clusters showing evidence of overconcentration are all lower-mass clusters. For the four lowest mass clusters the average value of the concentration parameter c{sub 200} is 11.6, while for the six higher-mass clusters the average value of c{sub 200} is 4.4. {Lambda}CDM would place c{sub 200} between 3.4 and 5.7.

The Sloan Digital Sky Survey Reverberation Mapping Project: Composite Lags at z ≤ 1

International Nuclear Information System (INIS)

Li, Jennifer; Shen, Yue; Horne, Keith; Brandt, W. N.; Grier, C. J.; Schneider, Donald P.; Greene, Jenny E.; Ho, Luis C.; Kochanek, Chris; Trump, Jonathan R.; Dawson, Kyle S.; Pan, Kaike; Bizyaev, Dmitry; Oravetz, Daniel; Simmons, Audrey; Malanushenko, Elena

2017-01-01

We present composite broad-line region (BLR) reverberation mapping lag measurements for H α , H β , He ii λ 4686, and Mg ii for a sample of 144, z ≲ 1 quasars from the Sloan Digital Sky Survey Reverberation Mapping (SDSS-RM) project. Using only the 32-epoch spectroscopic light curves in the first six-month season of SDSS-RM observations, we compile correlation function measurements for individual objects and then coadd them to allow the measurement of the average lags for our sample at mean redshifts of 0.4 (for H α ) and ∼0.65 (for the other lines). At similar quasar luminosities and redshifts, the sample-averaged lag decreases in the order of Mg ii, H α , H β , and He ii. This decrease in lags is accompanied by an increase in the mean line width of the four lines, and is roughly consistent with the virialized motion for BLR gas in photoionization equilibrium. These are among the first RM measurements of stratified BLR structure at z > 0.3. Dividing our sample by luminosity, H α shows clear evidence of increasing lags with luminosity, consistent with the expectation from the measured BLR size–luminosity relation based on H β . The other three lines do not show a clear luminosity trend in their average lags due to the limited dynamic range of luminosity probed and the poor average correlation signals in the divided samples, a situation that will be improved with the incorporation of additional photometric and spectroscopic data from SDSS-RM. We discuss the utility and caveats of composite lag measurements for large statistical quasar samples with reverberation mapping data.

Accessing forgotten memory traces from long-term memory via visual movements

Directory of Open Access Journals (Sweden)

Estela eCamara

2014-11-01

Full Text Available Because memory retrieval often requires overt responses, it is difficult to determine to what extend forgetting occurs as a problem in explicit accessing of long-term memory traces. In this study, we used eye-tracking measures in combination with a behavioural task that favoured high forgetting rates to investigate the existence of memory traces from long-term memory in spite of failure in accessing them consciously. In 2 experiments, participants were encouraged to encode a large set of sound-picture-location associations. In a later test, sounds were presented and participants were instructed to visually scan, before a verbal memory report, for the correct location of the associated pictures in an empty screen. We found the reactivation of associated memories by sound cues at test biased oculomotor behaviour towards locations congruent with memory representations, even when participants failed to consciously provide a memory report of it. These findings reveal the emergence of a memory-guided behaviour that can be used to map internal representations of forgotten memories from long-term memory.

Item memory, source memory, and the medial temporal lobe: Concordant findings from fMRI and memory-impaired patients

OpenAIRE

Gold, Jeffrey J.; Smith, Christine N.; Bayley, Peter J.; Shrager, Yael; Brewer, James B.; Stark, Craig E. L.; Hopkins, Ramona O.; Squire, Larry R.

2006-01-01

We studied item and source memory with fMRI in healthy volunteers and carried out a parallel study in memory-impaired patients. In experiment 1, volunteers studied a list of words in the scanner and later took an item memory test and a source memory test. Brain activity in the hippocampal region, perirhinal cortex, and parahippocampal cortex was associated with words that would later be remembered (item memory). The activity in these regions that predicted subsequent success at item memory pr...

Working memory affects false memory production for emotional events.

Science.gov (United States)

Mirandola, Chiara; Toffalini, Enrico; Ciriello, Alfonso; Cornoldi, Cesare

2017-01-01

Whereas a link between working memory (WM) and memory distortions has been demonstrated, its influence on emotional false memories is unclear. In two experiments, a verbal WM task and a false memory paradigm for negative, positive or neutral events were employed. In Experiment 1, we investigated individual differences in verbal WM and found that the interaction between valence and WM predicted false recognition, with negative and positive material protecting high WM individuals against false remembering; the beneficial effect of negative material disappeared in low WM participants. In Experiment 2, we lowered the WM capacity of half of the participants with a double task request, which led to an overall increase in false memories; furthermore, consistent with Experiment 1, the increase in negative false memories was larger than that of neutral or positive ones. It is concluded that WM plays a critical role in determining false memory production, specifically influencing the processing of negative material.

A shared resource between declarative memory and motor memory.

Science.gov (United States)

Keisler, Aysha; Shadmehr, Reza

2010-11-03

The neural systems that support motor adaptation in humans are thought to be distinct from those that support the declarative system. Yet, during motor adaptation changes in motor commands are supported by a fast adaptive process that has important properties (rapid learning, fast decay) that are usually associated with the declarative system. The fast process can be contrasted to a slow adaptive process that also supports motor memory, but learns gradually and shows resistance to forgetting. Here we show that after people stop performing a motor task, the fast motor memory can be disrupted by a task that engages declarative memory, but the slow motor memory is immune from this interference. Furthermore, we find that the fast/declarative component plays a major role in the consolidation of the slow motor memory. Because of the competitive nature of declarative and nondeclarative memory during consolidation, impairment of the fast/declarative component leads to improvements in the slow/nondeclarative component. Therefore, the fast process that supports formation of motor memory is not only neurally distinct from the slow process, but it shares critical resources with the declarative memory system.

A shared resource between declarative memory and motor memory

Science.gov (United States)

Keisler, Aysha; Shadmehr, Reza

2010-01-01

The neural systems that support motor adaptation in humans are thought to be distinct from those that support the declarative system. Yet, during motor adaptation changes in motor commands are supported by a fast adaptive process that has important properties (rapid learning, fast decay) that are usually associated with the declarative system. The fast process can be contrasted to a slow adaptive process that also supports motor memory, but learns gradually and shows resistance to forgetting. Here we show that after people stop performing a motor task, the fast motor memory can be disrupted by a task that engages declarative memory, but the slow motor memory is immune from this interference. Furthermore, we find that the fast/declarative component plays a major role in the consolidation of the slow motor memory. Because of the competitive nature of declarative and non-declarative memory during consolidation, impairment of the fast/declarative component leads to improvements in the slow/non-declarative component. Therefore, the fast process that supports formation of motor memory is not only neurally distinct from the slow process, but it shares critical resources with the declarative memory system. PMID:21048140

Tracing Cultural Memory

DEFF Research Database (Denmark)

Wiegand, Frauke Katharina

by their encounters – to address a question that thirty years of ground - breaking research into memory has not yet sufficiently answered: What can we learn about the dynamics of cultural memory by examining mundane accounts of touristic encounters with sites of memory? From Blaavand Beach in Western Denmark......We encounter, relate to and make use of our past and that of others in multifarious and increasingly mobile ways. Tourism is one of the main paths for encountering sites of memory. This thesis examines tourists’ creative appropriations of sites of memory – the objects and future memories inspired...... of memory. They highlight the role of mundane uses of the past and indicate the need for cross - disciplinary research on the visual and on memory...

Negative affect impairs associative memory but not item memory.

Science.gov (United States)

Bisby, James A; Burgess, Neil

2013-12-17

The formation of associations between items and their context has been proposed to rely on mechanisms distinct from those supporting memory for a single item. Although emotional experiences can profoundly affect memory, our understanding of how it interacts with different aspects of memory remains unclear. We performed three experiments to examine the effects of emotion on memory for items and their associations. By presenting neutral and negative items with background contexts, Experiment 1 demonstrated that item memory was facilitated by emotional affect, whereas memory for an associated context was reduced. In Experiment 2, arousal was manipulated independently of the memoranda, by a threat of shock, whereby encoding trials occurred under conditions of threat or safety. Memory for context was equally impaired by the presence of negative affect, whether induced by threat of shock or a negative item, relative to retrieval of the context of a neutral item in safety. In Experiment 3, participants were presented with neutral and negative items as paired associates, including all combinations of neutral and negative items. The results showed both above effects: compared to a neutral item, memory for the associate of a negative item (a second item here, context in Experiments 1 and 2) is impaired, whereas retrieval of the item itself is enhanced. Our findings suggest that negative affect impairs associative memory while recognition of a negative item is enhanced. They support dual-processing models in which negative affect or stress impairs hippocampal-dependent associative memory while the storage of negative sensory/perceptual representations is spared or even strengthened.

Memory Matters

Science.gov (United States)

... Staying Safe Videos for Educators Search English Español Memory Matters KidsHealth / For Kids / Memory Matters What's in ... of your complex and multitalented brain. What Is Memory? When an event happens, when you learn something, ...

Using the framework of corporate culture in “mergers” to support the development of a cultural basis for integrative medicine – guidance for building an integrative medicine department or service

Directory of Open Access Journals (Sweden)

Witt CM

2015-01-01

Full Text Available Claudia M Witt,1–3 Marion Pérard,2 Brian Berman,3,4 Susan Berman,4 Timothy C Birdsall,5 Horst Defren,6 Sherko Kümmel,7 Gary Deng,8 Gustav Dobos,9 Atje Drexler,10 Christine Holmberg,2 Markus Horneber,11 Robert Jütte,9 Lori Knutson,12 Christopher Kummer,13 Susanne Volpers,14 David Schweiger15 1University Hospital Zurich, Institute for Complementary and Integrative Medicine, Zurich, Switzerland; 2Institute for Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin, Berlin, Germany; 3University of Maryland School of Medicine, Center for Integrative Medicine, Baltimore, Maryland, USA; 4The Institute for Integrative Health, Baltimore, USA; 5Cancer Treatment Centers of America, Goodyear, Arizona, USA, 6Kliniken Essen Mitte, Evang, Huyssen-Stiftung/Knappschaft GmbH Patientenmanagement, Essen, Germany; 7Department of Senology, Breast Center, Kliniken Essen-Mitte, Evang. Huyssens Stiftung, Knappschaft GmbH, Essen, Germany; 8Memorial Sloan-Kettering Cancer Center, New York, USA; 9Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, Academic Teaching Hospital of the University of Duisburg-Essen, Germany; 10Robert Bosch Foundation GmbH, Stuttgart, Germany; 11Department of Internal Medicine, Division of Oncology and Hematology, Paracelsus Medical University, Klinikum Nürnberg, Germany; 12Integrative Healthcare Solutions, Minneapolis, Minnesota, USA; 13Institute of Mergers, Acquisitions and Alliances (IMAA, Zurich, Switzerland; 14Frauenselbsthilfe nach Krebs, Bonn, Germany; 15Schweiger, Schweiger & Associates, Hilton Head Island, South Carolina, USA Background: An increasing number of clinics offer complementary or integrative medicine services; however, clear guidance about how complementary medicine could be successfully and efficiently integrated into conventional health care settings is still lacking. Combining conventional and complementary medicine into integrative medicine can be regarded as a kind of

Memory design

DEFF Research Database (Denmark)

Tanderup, Sisse

by cultural forms, often specifically by the concept of memory in philosophy, sociology and psychology, while Danish design traditionally has been focusing on form and function with frequent references to the forms of nature. Alessi's motivation for investigating the concept of memory is that it adds......Mind and Matter - Nordik 2009 Conference for Art Historians Design Matters Contributed Memory design BACKGROUND My research concerns the use of memory categories in the designs by the companies Alessi and Georg Jensen. When Alessi's designers create their products, they are usually inspired...... a cultural dimension to the design objects, enabling the objects to make an identity-forming impact. Whether or not the concept of memory plays a significant role in Danish design has not yet been elucidated fully. TERMINOLOGY The concept of "memory design" refers to the idea that design carries...

Assessment of Cognitive Function in Breast Cancer and Lymphoma Patients Receiving Chemotherapy | Division of Cancer Prevention

Science.gov (United States)

Cognitive impairments in cancer patients represent an important clinical problem. Studies to date estimating prevalence of difficulties in memory, executive function, and attention deficits have been limited by small sample sizes and many have lacked healthy control groups. More information is needed on promising biomarkers and allelic variants that may help to determine the

Optical spectroscopic observations of blazars and γ-ray blazar candidates in the sloan digital sky survey data release nine

Energy Technology Data Exchange (ETDEWEB)

Massaro, F.; Masetti, N.; D' Abrusco, R.; Paggi, A.; Funk, S.

2014-09-09

We present an analysis of the optical spectra available in the Sloan Digital Sky Survey data release nine (SDSS DR9) for the blazars listed in the ROMA-BZCAT and for the γ-ray blazar candidates selected according to their IR colors. First, we adopt a statistical approach based on Monte Carlo simulations to find the optical counterparts of the blazars listed in the ROMA-BZCAT catalog. Then, we crossmatched the SDSS spectroscopic catalog with our selected samples of blazars and γ-ray blazar candidates, searching for those with optical spectra available to classify our blazar-like sources and, whenever possible, to confirm their redshifts. Our main objectives are to determine the classification of uncertain blazars listed in the ROMA-BZCAT and to discover new gamma-ray blazars. For the ROMA-BZCAT sources, we investigated a sample of 84 blazars, confirming the classification for 20 of them and obtaining 18 new redshift estimates. For the γ-ray blazars, indicated as potential counterparts of unassociated Fermi sources or with uncertain nature, we established the blazar-like nature of 8 out of the 27 sources analyzed and confirmed 14 classifications.

Immune Curbing of Cancer Stem Cells by CTLs Directed to NANOG

Directory of Open Access Journals (Sweden)

Christina Wefers

2018-06-01

Full Text Available Cancer stem cells (CSCs have been identified as the source of tumor growth and disease recurrence. Eradication of CSCs is thus essential to achieve durable responses, but CSCs are resistant to current anti-tumor therapies. Novel therapeutic approaches that specifically target CSCs will, therefore, be crucial to improve patient outcome. Immunotherapies, which boost the body’s own immune system to eliminate cancerous cells, could be an alternative approach to target CSCs. Vaccines of dendritic cells (DCs loaded with tumor antigens can evoke highly specific anti-tumor T cell responses. Importantly, DC vaccination also promotes immunological memory formation, paving the way for long-term cancer control. Here, we propose a DC vaccination that specifically targets CSCs. DCs loaded with NANOG peptides, a protein required for maintaining stem cell properties, could evoke a potent anti-tumor immune response against CSCs. We hypothesize that the resulting immunological memory will also control newly formed CSCs, thereby preventing disease recurrence.

HIDING IN PLAIN SIGHT: RECORD-BREAKING COMPACT STELLAR SYSTEMS IN THE SLOAN DIGITAL SKY SURVEY

International Nuclear Information System (INIS)

Sandoval, Michael A.; Vo, Richard P.; Romanowsky, Aaron J.; Strader, Jay; Choi, Jieun; Conroy, Charlie; Jennings, Zachary G.; Villaume, Alexa; Brodie, Jean P.; Foster, Caroline; Norris, Mark A.; Janz, Joachim; Forbes, Duncan A.

2015-01-01

Motivated by the recent, serendipitous discovery of the densest known galaxy, M60-UCD1, we present two initial findings from a follow-up search, using the Sloan Digital Sky Survey, Subaru/Suprime-Cam, and Hubble Space Telescope imaging, and SOuthern Astrophysical Research (SOAR)/Goodman spectroscopy. The first object discovered, M59-UCD3, has a similar size to M60-UCD1 (half-light radius of r h ∼ 20 pc) but is 40% more luminous (M V ∼ −14.6), making it the new densest-known galaxy. The second, M85-HCC1, has a size like a typical globular cluster (GC; r h ∼ 1.8 pc) but is much more luminous (M V ∼ −12.5). This hypercompact cluster is by far the densest confirmed free-floating stellar system, and is equivalent to the densest known nuclear star clusters. From spectroscopy, we find that both objects are relatively young (∼9 and ∼3 Gyr, respectively), with metal-abundances that resemble those of galaxy centers. Their host galaxies show clear signs of large-scale disturbances, and we conclude that these dense objects are the remnant nuclei of recently accreted galaxies. M59-UCD3 is an ideal target for follow-up with high-resolution imaging and spectroscopy to search for an overweight central supermassive black hole as was discovered in M60-UCD1. These findings also emphasize the potential value of ultra-compact dwarfs and massive GCs as tracers of the assembly histories of galaxies

THE SLOAN DIGITAL SKY SURVEY REVERBERATION MAPPING PROJECT: RAPID C iv BROAD ABSORPTION LINE VARIABILITY

Energy Technology Data Exchange (ETDEWEB)

Grier, C. J.; Brandt, W. N.; Trump, J. R.; Schneider, D. P. [Department of Astronomy and Astrophysics and Institute for Gravitation and the Cosmos, The Pennsylvania State University, 525 Davey Laboratory, University Park, PA 16802 (United States); Hall, P. B. [Department of Physics and Astronomy, York University, Toronto, ON M3J 1P3 (Canada); Shen, Yue [Carnegie Observatories, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); Vivek, M.; Dawson, K. S. [Department of Physics and Astronomy, University of Utah, Salt Lake City, UT 84112 (United States); Ak, N. Filiz [Faculty of Sciences, Department of Astronomy and Space Sciences, Erciyes University, 38039 Kayseri (Turkey); Chen, Yuguang [Department of Astronomy, School of Physics, Peking University, Beijing 100871 (China); Denney, K. D.; Kochanek, C. S.; Peterson, B. M. [Department of Astronomy, The Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States); Green, Paul J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Jiang, Linhua [Kavli Institute for Astronomy and Astrophysics, Peking University, Beijing 100871 (China); McGreer, Ian D. [Steward Observatory, The University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721-0065 (United States); Pâris, I. [INAF-Osservatorio Astronomico di Trieste, Via G. B. Tiepolo 11, I-34131 Trieste (Italy); Tao, Charling [Centre de Physique des Particules de Marseille, Aix-Marseille Universite, CNRS /IN2P3, 163, avenue de Luminy, Case 902, F-13288 Marseille Cedex 09 (France); Wood-Vasey, W. M. [PITT PACC, Department of Physics and Astronomy, University of Pittsburgh, 3941 O’Hara Street, Pittsburgh, PA 15260 (United States); Bizyaev, Dmitry, E-mail: grier@psu.edu [Apache Point Observatory and New Mexico State University, P.O. Box 59, Sunspot, NM, 88349-0059 (United States); and others

2015-06-10

We report the discovery of rapid variations of a high-velocity C iv broad absorption line trough in the quasar SDSS J141007.74+541203.3. This object was intensively observed in 2014 as a part of the Sloan Digital Sky Survey Reverberation Mapping Project, during which 32 epochs of spectroscopy were obtained with the Baryon Oscillation Spectroscopic Survey spectrograph. We observe significant (>4σ) variability in the equivalent width (EW) of the broad (∼4000 km s{sup −1} wide) C iv trough on rest-frame timescales as short as 1.20 days (∼29 hr), the shortest broad absorption line variability timescale yet reported. The EW varied by ∼10% on these short timescales, and by about a factor of two over the duration of the campaign. We evaluate several potential causes of the variability, concluding that the most likely cause is a rapid response to changes in the incident ionizing continuum. If the outflow is at a radius where the recombination rate is higher than the ionization rate, the timescale of variability places a lower limit on the density of the absorbing gas of n{sub e} ≳ 3.9 × 10{sup 5} cm{sup −3}. The broad absorption line variability characteristics of this quasar are consistent with those observed in previous studies of quasars, indicating that such short-term variability may in fact be common and thus can be used to learn about outflow characteristics and contributions to quasar/host-galaxy feedback scenarios.

HIDING IN PLAIN SIGHT: RECORD-BREAKING COMPACT STELLAR SYSTEMS IN THE SLOAN DIGITAL SKY SURVEY

Energy Technology Data Exchange (ETDEWEB)

Sandoval, Michael A.; Vo, Richard P.; Romanowsky, Aaron J. [Department of Physics and Astronomy, San José State University, One Washington Square, San Jose, CA 95192 (United States); Strader, Jay [Department of Physics and Astronomy, Michigan State University, East Lansing, MI 48824 (United States); Choi, Jieun; Conroy, Charlie [Harvard–Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Jennings, Zachary G.; Villaume, Alexa [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Brodie, Jean P. [University of California Observatories, 1156 High Street, Santa Cruz, CA 95064 (United States); Foster, Caroline [Australian Astronomical Observatory, P.O. Box 915, North Ryde, NSW 1670 (Australia); Norris, Mark A. [Max Planck Institut für Astronomie, Königstuhl 17, D-69117, Heidelberg (Germany); Janz, Joachim; Forbes, Duncan A. [Centre for Astrophysics and Supercomputing, Swinburne University, Hawthorn, VIC 3122 (Australia)

2015-07-20

Motivated by the recent, serendipitous discovery of the densest known galaxy, M60-UCD1, we present two initial findings from a follow-up search, using the Sloan Digital Sky Survey, Subaru/Suprime-Cam, and Hubble Space Telescope imaging, and SOuthern Astrophysical Research (SOAR)/Goodman spectroscopy. The first object discovered, M59-UCD3, has a similar size to M60-UCD1 (half-light radius of r{sub h} ∼ 20 pc) but is 40% more luminous (M{sub V} ∼ −14.6), making it the new densest-known galaxy. The second, M85-HCC1, has a size like a typical globular cluster (GC; r{sub h} ∼ 1.8 pc) but is much more luminous (M{sub V} ∼ −12.5). This hypercompact cluster is by far the densest confirmed free-floating stellar system, and is equivalent to the densest known nuclear star clusters. From spectroscopy, we find that both objects are relatively young (∼9 and ∼3 Gyr, respectively), with metal-abundances that resemble those of galaxy centers. Their host galaxies show clear signs of large-scale disturbances, and we conclude that these dense objects are the remnant nuclei of recently accreted galaxies. M59-UCD3 is an ideal target for follow-up with high-resolution imaging and spectroscopy to search for an overweight central supermassive black hole as was discovered in M60-UCD1. These findings also emphasize the potential value of ultra-compact dwarfs and massive GCs as tracers of the assembly histories of galaxies.

Memories of significant episodes in child psychotherapy: an autobiographical memory approach.

Science.gov (United States)

Andersson, Gerhard; Boalt Boethius, Siv; Svirsky, Liv; Carlberg, Gunnar

2006-06-01

In this study, child psychotherapists (N=31) were asked to retrieve emotionally valenced therapy episodes by using an autobiographical memory approach, with cue words to elicit specific therapy episodes (e.g. irritated, ashamed, loving, and elated). One group of teachers for the disabled (N=10) and one group of music therapists (N=9) were also tested and served as comparison groups. Results showed that all participants were able to retrieve memories of episodes. When asked to rate each memory, negative memories were returned to less often, and overall positive memories were rated as more easy to recall and more vivid. Memories derived from positive cue words were also judged to have a more positive compared with negative importance for outcome. Surprisingly, memories derived from the cue word irritated were seen as having more positive than negative importance for outcome. Finally, we checked memory specificity for each memory derived. A high degree of specificity was found overall (72-88%). In conclusion, cue words might be a useful way to generate specific memories of therapy episodes in future research.

Multistate Resistive Switching Memory for Synaptic Memory Applications

KAUST Repository

Hota, Mrinal Kanti

2016-07-12

Reproducible low bias bipolar resistive switching memory in HfZnOx based memristors is reported. The modification of the concentration of oxygen vacancies in the ternary oxide film, which is facilitated by adding ZnO into HfO2, results in improved memory operation by the ternary oxide compared to the single binary oxides. A controlled multistate memory operation is achieved by controlling current compliance and RESET stop voltages. A high DC cyclic stability up to 400 cycles in the multistate memory performance is observed. Conventional synaptic operation in terms of potentiation, depression plasticity, and Ebbinghaus forgetting process are also studied. The memory mechanism is shown to originate from the migration of the oxygen vacancies and modulation of the interfacial layers. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Subjective memory complaints are associated with brain activation supporting successful memory encoding.

Science.gov (United States)

Hayes, Jessica M; Tang, Lingfei; Viviano, Raymond P; van Rooden, Sanneke; Ofen, Noa; Damoiseaux, Jessica S

2017-12-01

Subjective memory complaints, the perceived decline in cognitive abilities in the absence of clinical deficits, may precede Alzheimer's disease. Individuals with subjective memory complaints show differential brain activation during memory encoding; however, whether such differences contribute to successful memory formation remains unclear. Here, we investigated how subsequent memory effects, activation which is greater for hits than misses during an encoding task, differed between healthy older adults aged 50 to 85 years with (n = 23) and without (n = 41) memory complaints. Older adults with memory complaints, compared to those without, showed lower subsequent memory effects in the occipital lobe, superior parietal lobe, and posterior cingulate cortex. In addition, older adults with more memory complaints showed a more negative subsequent memory effects in areas of the default mode network, including the posterior cingulate cortex, precuneus, and ventromedial prefrontal cortex. Our findings suggest that for successful memory formation, older adults with subjective memory complaints rely on distinct neural mechanisms which may reflect an overall decreased task-directed attention. Copyright © 2017 Elsevier Inc. All rights reserved.

Sleep enhances false memories depending on general memory performance.

Science.gov (United States)

Diekelmann, Susanne; Born, Jan; Wagner, Ullrich

2010-04-02

Memory is subject to dynamic changes, sometimes giving rise to the formation of false memories due to biased processes of consolidation or retrieval. Sleep is known to benefit memory consolidation through an active reorganization of representations whereas acute sleep deprivation impairs retrieval functions. Here, we investigated whether sleep after learning and sleep deprivation at retrieval enhance the generation of false memories in a free recall test. According to the Deese, Roediger, McDermott (DRM) false memory paradigm, subjects learned lists of semantically associated words (e.g., "night", "dark", "coal", etc.), lacking the strongest common associate or theme word (here: "black"). Free recall was tested after 9h following a night of sleep, a night of wakefulness (sleep deprivation) or daytime wakefulness. Compared with memory performance after a retention period of daytime wakefulness, both post-learning nocturnal sleep as well as acute sleep deprivation at retrieval significantly enhanced false recall of theme words. However, these effects were only observed in subjects with low general memory performance. These data point to two different ways in which sleep affects false memory generation through semantic generalization: one acts during consolidation on the memory trace per se, presumably by active reorganization of the trace in the post-learning sleep period. The other is related to the recovery function of sleep and affects cognitive control processes of retrieval. Both effects are unmasked when the material is relatively weakly encoded. Crown Copyright 2009. Published by Elsevier B.V. All rights reserved.

Memory Modulation

NARCIS (Netherlands)

Roozendaal, Benno; McGaugh, James L.

2011-01-01

Our memories are not all created equally strong: Some experiences are well remembered while others are remembered poorly, if at all. Research on memory modulation investigates the neurobiological processes and systems that contribute to such differences in the strength of our memories. Extensive

Working Memory, Long-Term Memory, and Medial Temporal Lobe Function

Science.gov (United States)

Jeneson, Annette; Squire, Larry R.

2012-01-01

Early studies of memory-impaired patients with medial temporal lobe (MTL) damage led to the view that the hippocampus and related MTL structures are involved in the formation of long-term memory and that immediate memory and working memory are independent of these structures. This traditional idea has recently been revisited. Impaired performance…

Negative affect impairs associative memory but not item memory.

OpenAIRE

Bisby, J. A.; Burgess, N.

2014-01-01

The formation of associations between items and their context has been proposed to rely on mechanisms distinct from those supporting memory for a single item. Although emotional experiences can profoundly affect memory, our understanding of how it interacts with different aspects of memory remains unclear. We performed three experiments to examine the effects of emotion on memory for items and their associations. By presenting neutral and negative items with background contexts, Experiment 1 ...

The Sloan Digital Sky Survey Quasar Lens Search. IV. Statistical Lens Sample from the Fifth Data Release

Energy Technology Data Exchange (ETDEWEB)

Inada, Naohisa; /Wako, RIKEN /Tokyo U., ICEPP; Oguri, Masamune; /Natl. Astron. Observ. of Japan /Stanford U., Phys. Dept.; Shin, Min-Su; /Michigan U. /Princeton U. Observ.; Kayo, Issha; /Tokyo U., ICRR; Strauss, Michael A.; /Princeton U. Observ.; Hennawi, Joseph F.; /UC, Berkeley /Heidelberg, Max Planck Inst. Astron.; Morokuma, Tomoki; /Natl. Astron. Observ. of Japan; Becker, Robert H.; /LLNL, Livermore /UC, Davis; White, Richard L.; /Baltimore, Space Telescope Sci.; Kochanek, Christopher S.; /Ohio State U.; Gregg, Michael D.; /LLNL, Livermore /UC, Davis /Exeter U.

2010-05-01

We present the second report of our systematic search for strongly lensed quasars from the data of the Sloan Digital Sky Survey (SDSS). From extensive follow-up observations of 136 candidate objects, we find 36 lenses in the full sample of 77,429 spectroscopically confirmed quasars in the SDSS Data Release 5. We then define a complete sample of 19 lenses, including 11 from our previous search in the SDSS Data Release 3, from the sample of 36,287 quasars with i < 19.1 in the redshift range 0.6 < z < 2.2, where we require the lenses to have image separations of 1 < {theta} < 20 and i-band magnitude differences between the two images smaller than 1.25 mag. Among the 19 lensed quasars, 3 have quadruple-image configurations, while the remaining 16 show double images. This lens sample constrains the cosmological constant to be {Omega}{sub {Lambda}} = 0.84{sub -0.08}{sup +0.06}(stat.){sub -0.07}{sup + 0.09}(syst.) assuming a flat universe, which is in good agreement with other cosmological observations. We also report the discoveries of 7 binary quasars with separations ranging from 1.1 to 16.6, which are identified in the course of our lens survey. This study concludes the construction of our statistical lens sample in the full SDSS-I data set.

Emerging non-volatile memories

CERN Document Server

Hong, Seungbum; Wouters, Dirk

2014-01-01

This book is an introduction to the fundamentals of emerging non-volatile memories and provides an overview of future trends in the field. Readers will find coverage of seven important memory technologies, including Ferroelectric Random Access Memory (FeRAM), Ferromagnetic RAM (FMRAM), Multiferroic RAM (MFRAM), Phase-Change Memories (PCM), Oxide-based Resistive RAM (RRAM), Probe Storage, and Polymer Memories. Chapters are structured to reflect diffusions and clashes between different topics. Emerging Non-Volatile Memories is an ideal book for graduate students, faculty, and professionals working in the area of non-volatile memory. This book also: Covers key memory technologies, including Ferroelectric Random Access Memory (FeRAM), Ferromagnetic RAM (FMRAM), and Multiferroic RAM (MFRAM), among others. Provides an overview of non-volatile memory fundamentals. Broadens readers' understanding of future trends in non-volatile memories.

Concurrent performance of two memory tasks: evidence for domain-specific working memory systems.

Science.gov (United States)

Cocchini, Gianna; Logie, Robert H; Della Sala, Sergio; MacPherson, Sarah E; Baddeley, Alan D

2002-10-01

Previous studies of dual-task coordination in working memory have shown a lack of dual-task interference when a verbal memory task is combined with concurrent perceptuomotor tracking. Two experiments are reported in which participants were required to perform pairwise combinations of (1) a verbal memory task, a visual memory task, and perceptuomotor tracking (Experiment 1), and (2) pairwise combinations of the two memory tasks and articulatory suppression (Experiment 2). Tracking resulted in no disruption of the verbal memory preload over and above the impact of a delay in recall and showed only minimal disruption of the retention of the visual memory load. Performing an ongoing verbal memory task had virtually no impact on retention of a visual memory preload or vice versa, indicating that performing two demanding memory tasks results in little mutual interference. Experiment 2 also showed minimal disruption when the two memory tasks were combined, although verbal memory (but not visual memory) was clearly disrupted by articulatory suppression interpolated between presentation and recall. These data suggest that a multiple-component working memory model provides a better account for performance in concurrent immediate memory tasks than do theories that assume a single processing and storage system or a limited-capacity attentional system coupled with activated memory traces.

Wormholes in Memory: Is memory one representation or many?

OpenAIRE

Wulff Dirk U. Hills Thomas T. Hertwig Ralph

2013-01-01

The analogy of space to human cognition has a long standing tradition. Our study aims to elaborate on the validity of this analogy for search in memory. Using the search of associative memory framework (SAM) we show that people are able to dynamically recruit independent memory representations in the recall of country names. By instructing participants to use specific recall cues we also show that despite a strong effect on the retrieval sequence total recall from memory remains unaffected. ...

When Delays Improve Memory: Stabilizing Memory in Children May Require Time.

Science.gov (United States)

Darby, Kevin P; Sloutsky, Vladimir M

2015-12-01

Memory is critical for learning, cognition, and cognitive development. Recent work has suggested that preschool-age children are vulnerable to catastrophic levels of memory interference, in which new learning dramatically attenuates memory for previously acquired knowledge. In the work reported here, we investigated the effects of consolidation on children's memory by introducing a 48-hr delay between learning and testing. In Experiment 1, the delay improved children's memory and eliminated interference. Results of Experiment 2 suggest that the benefit of this delay is limited to situations in which children are given enough information to form complex memory structures. These findings have important implications for understanding consolidation processes and memory development. © The Author(s) 2015.

False Memories and Reproductive Imagination: Ricoeur’s Phenomenology of Memory

Directory of Open Access Journals (Sweden)

Man-to TANG

2015-06-01

Full Text Available In cognitive psychology, a false memory refers to a fabricated or distorted recollection of an event that did not actually happen. Both ‘memory-distortion’ and ‘false memory creation’ refer to the processes of recollection in which the recollected events are not actually happened. This paper has three aims: (1 to examine Ricoeur’s analysis of memory and imagination; (2 to explain and reinforce the constructive role of memory; (3 to show in what manner the first two aims lead to the conclusion that the phenomena of ‘distorted or false memory creation’ are reproductive because the nature of recollection is constructive in the sense of representation of past. In this regard, Ricoeur’s trajectory not only displaces the essential structure of memory and imagination behind the curtain of their distinction and connection, but also contributes to the debates in cognitive psychology.