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Sample records for cancer institute cairo

  1. A clinicoepidemiological study of esophageal cancer patients at the National Cancer Institute, Cairo University, Egypt

    Institute of Scientific and Technical Information of China (English)

    Soumaya Ezzat; Hisham El Hossieny; Mohamed Abd Alla; Azza Nasr; Nagwan Anter; Ahmed Adel

    2016-01-01

    Objective The purposes of this study were to (1) assess the clinicoepidemiological characteristics of esopha-geal cancer patients, (2) analyze the prognostic factors determining treatment failure and survival, and (3) evaluate the results of various treatment modalities for locoregional and disseminated disease and their ef ect on disease-free survival and overal survival (OS). Methods Clinicoepidemiological retrospective data from 81 esophageal cancer patients treated at the Na-tional Cancer Institute of Cairo between 2007 and 2011 were evaluated. Results The study showed that patients with esophageal cancer commonly present with local y advanced disease (87.7% had T-stage 3 and 12.3% had T-stage 4). There was a significant correlation between surgery and survival; patients who received radical surgery and postoperative radiation had a better median survival than patients who received radical radiotherapy (20 months vs. 16 months, respectively; P = 0.04). There was also a significant statistical correlation between radical concomitant chemoradiotherapy (NCRT) and pal iative treatment. Patients who received radical NCRT had a better median survival than patients who received pal-liative radiotherapy (16 months vs. 10 months, respectively; P = 0.001). The median fol ow-up period for al patients was 7 months. The median OS of the whole group was 12 months. The OS after 1 and 2 years was 57.8% and 15%, respectively. Conclusion High-dose NCRT is an acceptable alternative for patients unfit for surgery or with inoperable disease. High-dose radiation is more ef ective than low-dose radiation in terms of local control, time to relapse, and OS. Further study using a larger series of patients and introducing new treatment protocols is necessary for a final evaluation.

  2. CLINICAL FEATURES AND CLINICAL OUTCOME OF ACUTE PROMYELOCYTIC LEUKEMIA PATIENTS TREATED AT CAIRO NATIONAL CANCER INSTITUTE IN EGYPT

    Directory of Open Access Journals (Sweden)

    Tamer M Fouad

    2011-01-01

    Full Text Available

    The current study reports the clinical features and treatment outcome of 67 patients with acute promyelocytic leukemia (APL presented to National Cancer Institute (NCI-Cairo, in Egypt from January 2007 to January 2011. The median follow-up time was 36 months. All patients were treated with the simultaneous administration of all-trans retinoic acid (ATRA and anthracyclin. The treatment protocol was modified due to resource limitations at the NCI-Cairo by replacing of idarubicin with doxorubicin in most of the cases and the inclusion of cytarbine during the consolidation phase only in pediatric patients. All patients who achieved molecular complete remission (CRm after consolidation received two-year maintenance treatment with low dose chemotherapy composed of 6 mercaptopurine, methotrexate and intermittent ATRA courses. The median age at presentation was 29 years. There was a slight male predominance (53%.  Bleeding was the most common presenting symptom (79%. Most patients had an intermediate risk Sanz score (49% and 34% had a high risk score.  All patients achieved molecular CR at end of consolidation therapy with a median duration of 100 days. The main therapeutic complications during the induction phase were febrile neutropenia (42%, bleeding (18% and differentiation syndrome (11%. Five patients died at diagnosis due to bleeding, three died during induction chemotherapy due to febrile neutropenia (n=2 and bleeding (n=1 and one patient died during consolidation therapy due to febrile neutropenia.  The 3-year OS was 89% and relapse rate was 3%. Adapting standard AIDA treatment protocols to limited resources by reducing dose-intensity during treatment consolidation, using ATRA in the consolidation phase and alternative anthracyclin (doxorubicin may be a valid treatment option in developing countries. In spite of the increased incidence of high and intermediate risk score APL in our sample, we reported an acceptable CR rate

  3. CLINICAL FEATURES AND CLINICAL OUTCOME OF ACUTE PROMYELOCYTIC LEUKEMIA PATIENTS TREATED AT CAIRO NATIONAL CANCER INSTITUTE IN EGYPT

    Directory of Open Access Journals (Sweden)

    Ola Khorshid

    2011-12-01

    Full Text Available The current study reports the clinical features and treatment outcome of 67 patients with acute promyelocytic leukemia (APL presented to National Cancer Institute (NCI-Cairo, in Egypt from January 2007 to January 2011. The median follow-up time was 36 months. All patients were treated with the simultaneous administration of all-trans retinoic acid (ATRA and anthracyclin. The treatment protocol was modified due to resource limitations at the NCI-Cairo by replacing of idarubicin with doxorubicin in most of the cases and the inclusion of cytarbine during the consolidation phase only in pediatric patients. All patients who achieved molecular complete remission (CRm after consolidation received two-year maintenance treatment with low dose chemotherapy composed of 6 mercaptopurine, methotrexate and intermittent ATRA courses. The median age at presentation was 29 years. There was a slight male predominance (53%.  Bleeding was the most common presenting symptom (79%. Most patients had an intermediate risk Sanz score (49% and 34% had a high risk score.  All patients achieved molecular CR at end of consolidation therapy with a median duration of 100 days. The main therapeutic complications during the induction phase were febrile neutropenia (42%, bleeding (18% and differentiation syndrome (11%. Five patients died at diagnosis due to bleeding, three died during induction chemotherapy due to febrile neutropenia (n=2 and bleeding (n=1 and one patient died during consolidation therapy due to febrile neutropenia.  The 3-year OS was 89% and relapse rate was 3%. Adapting standard AIDA treatment protocols to limited resources by reducing dose-intensity during treatment consolidation, using ATRA in the consolidation phase and alternative anthracyclin (doxorubicin may be a valid treatment option in developing countries. In spite of the increased incidence of high and intermediate risk score APL in our sample, we reported an acceptable CR rate, toxicity and OS.

  4. Correlation of Karyotype and Immuno phenotype in Childhood Acute Lymphoblastic Leukemia; Experience at the National Cancer Institute, Cairo University,Egypt,

    International Nuclear Information System (INIS)

    Purpose: To identify chromosomal pattern among the major immunophenotypic subgroups in Egyptian children with ALL, and its correlation with clinical presentation and disease free survival. Patients and Methods: Cytogenetic and immunophenotypic analysis were done for all patients. Patients received ALL-PNCI-III/98 chemotherapy protocol used at NCI, Cairo University. Results: The frequency of pseudodiploidy and normal karyotype in the whole group was 42.9% and 33.3% respectively. The frequency of pseudodiploidy was 36.8% in CALLA positive early pre B, 30.7% in pre B cases, 71.4% in T cell cases and 100% in mature B cell cases. At 12 months, DFS was 50% for pseudodiploid group having pre B phenotype, compared to 16.6% for pseudodiploid group with CALLA positive early pre B ALL. Sixteen percent of the studied cases showed T cell phenotype, 71.4% of them showed pseudodiploid karyotype, all of them had high risk features. Hyperdiploidy was found in 31.5% of CALLA positive early pre B cases and was associated with favorable prognostic features and DFS of 66.6% at 12 months. Hyperdiploidy of >50 chromosome represented 62.5% of hyperdipoid cases, 80% of them were CALLA positive early pre B ALL carrying good risk features. Fifty percent of normal karyotypic patients showed pre B phenotype, while 42.8% showed CALLA positive early pre B ALL. Their age, TLC, DFS, were almost comparable. Conclusion: CALLA early pre B phenotype has a positive impact on chromosomal pattern having best outcome among patients with hyperdiploidy. The Pseudodiploid karyotype carries a better outcome with pre B phenotype

  5. The CAIRO4 study

    DEFF Research Database (Denmark)

    de Wilt, Johannes H W; Verhoef, Cornelis; Punt, Cornelis J A;

    2016-01-01

    stages of the disease. We here propose a randomized trial in order to demonstrate that resection of the primary tumour improves overall survival. METHODS/DESIGN: The CAIRO4 study is a multicentre, randomized, phase III study of the Dutch Colorectal Cancer Group (DCCG). Patients with synchronous...

  6. The CAIRO4 study

    DEFF Research Database (Denmark)

    't Lam-Boer, Jorine; Mol, Linda; Verhoef, Cornelis;

    2015-01-01

    stages of the disease. We here propose a randomized trial in order to demonstrate that resection of the primary tumour improves overall survival. METHODS/DESIGN: The CAIRO4 study is a multicentre, randomized, phase III study of the Dutch Colorectal Cancer Group (DCCG). Patients with synchronous...

  7. Peralta Cancer Research Institute

    International Nuclear Information System (INIS)

    The investigators in the cell biology program at PCRI have pioneered in the development of techniques for culturing human epithelial cells. The cancer diagnosis program has been concerned with researching new techniques for early diagnosis of breast cancer in women. The cancer treatment program has been concerned with applying cell biology and biochemistry advances to improve cancer management

  8. A report from Cairo.

    Science.gov (United States)

    Shortridge, J

    1995-01-01

    The Sexuality Information and Education Council of the United States (SIECUS) is the only national organization in the US with a primary emphasis upon sexuality education. A 1992 review by SIECUS of the libraries of 17 population-related organizations found none to have a significant collection on sexuality or sexuality education. The nongovernmental organization (NGO) therefore in 1993 added an international component to its sexuality information and education clearinghouse, providing assistance to more than 250 professionals in over 30 countries in the first year. This was made possible through SIECUS's extensive collection of sexuality and HIV/AIDS education curricula, international research studies and reports, sexuality training models, conference and meeting proceedings, country policies, and program assessments. As an official accredited organization at the NGO forum in Cairo, Egypt, September 1994, SIECUS was able to assess the level of awareness and knowledge of sexuality issues among international population, health, environment, and government institutions. Participation in the meetings also offered the opportunity to evaluate the direction of the international initiative and support sexual and reproductive rights. The International Conference on Population and Development Program of Action is discussed. With the Cairo conference representing considerable progress on many fronts, SIECUS now believes that appropriate responses to world population growth must acknowledge the interactions among social, cultural, economic, and environmental conditions. Sexuality education and health services are an integral component of efforts to improve reproductive health care. In the coming year, SIECUS will develop materials to meet gaps in information, create a forum on the Internet to enhance communication efforts of professionals from other countries, and disseminate information to educators and service providers outside of the US. PMID:12288558

  9. National Cancer Institute

    Science.gov (United States)

    ... Español 1-800-4-CANCER Live Chat Publications Dictionary Menu Contact Dictionary Search About Cancer Causes and Prevention Risk Factors ... Contacts Other Funding Find NCI funding for small business innovation, technology transfer, and contracts Training Cancer Training ...

  10. Prevalence of bone marrow necrosis in Egyptian cancer patients referring to the National Cancer Institute

    International Nuclear Information System (INIS)

    Bone marrow necrosis; Egyptian cancer patients Abstract Background: Bone marrow necrosis is a relatively rare entity which has been associated with a poor prognosis. It is most commonly found in patients with neoplastic disorders and severe infections. Methods: study comprised examination of 5043 bone marrow biopsy specimens performed at the National Cancer Institute, Cairo University, over 7 years period (March 2004-March 2011). It included 5 years retrospective (2867 archived samples) and 2 years prospective (2176 samples). Results: Bone marrow necrosis was diagnosed in fifteen out of 5043 examined specimens with a percentage of 0.3% and ranged from mild to massive according to semiquantitative estimation. Prognosis of all patients was poor with survival not exceeding 6 months from the date of marrow necrosis diagnosis. Conclusion: In Egyptian patients, bone marrow necrosis in association with malignancy is a rare disorder which is accompanied by a poor outcome

  11. ICMIC Institutions - Cancer Imaging Program

    Science.gov (United States)

    ICMIC grants facilitate interaction among scientists from a variety of fields to conduct multidisciplinary research on cellular and molecular imaging related to cancer. Pre-ICMIC planning grants have provided time and funds for investigators and institutions to prepare themselves, organizationally and scientifically, to establish ICMICs.

  12. Cairo%开罗

    Institute of Scientific and Technical Information of China (English)

    张梦华

    2003-01-01

    @@ Cairo, the cradle of civilization, the Melting Pot of Ancient and Modern Egyptian Civilizations. It is the largest city in the Middle East and lies at the center of all routes leading to and from the three continents: Asia, Africa and Europe.

  13. Teaching in Cairo

    Science.gov (United States)

    Jones, Gary H.

    2007-01-01

    In this article, the author shares his teaching experience at Sadat Academy--a four-year business college located in Cairo, Egypt--where he taught business ethics and organizational behavior to 240 students. He also describes his students' behavior and how he was warmly welcomed by the people despite the fact the he is an American.

  14. [Cairo: a double deception].

    Science.gov (United States)

    Vallin, J

    1994-01-01

    The 3rd International Conference on Population and Development, held in Cairo in September 1994, was attended by 180 delegations of UN members and 15,000 participants in both the official conference and a vast forum of nongovernmental organizations. The nearly universal national representation, despite absence of Saudi Arabia, Sudan, and some other Islamic countries, was a great achievement for the conference organizers and the host country. Each delegation expressed its views in an official declaration to the plenary session, while representatives to the main committee debated the program of action drafted in a long series of meetings in preparation for the conference. None of the preparations or addresses to the conference were able to prevent an unrewarding seven-day debate in the main committee over abortion. More disappointing was the failure to engage in a deep debate over development issues. A number of recommendations touched on education, health, and improving the status of women, but only as factors in fertility decline. The issue of development should have been discussed as it relates to the satisfaction of the needs of the five billion living inhabitants of the planet and the ten billion projected for the next century. The second great disappointment of the conference was that some of the progressive contents of the preliminary document submitted to the conference were greatly watered down. The preliminary document offered real progress in achieving a more lucid and ideology-free approach to questions that have long remained taboo because they touch on the freedoms of men and women in their most profoundly intimate aspects. The text clarified aspects of the rights of individuals in relation to social institutions: the right to health and education in sexuality and reproduction, recognition of the existence of different types of unions and families, and the right to family regrouping. Most of the innovative articles provoked controversy in the

  15. American Institute for Cancer Research

    Science.gov (United States)

    ... Order Publications Shop AICR Health @ Work Healthy Recipes Cancer Research Update AICR eNews AICR Newsletter ScienceNow CancerResource Where ... Patients and Survivors Materials for Health Professionals Our Cancer Research Research Grants Conference Continuous Update Project Research Progress ...

  16. [The silences of Cairo].

    Science.gov (United States)

    Ghazi, S

    1994-10-01

    At the Conference on Population and the Environment in Cairo, the Vatican, Malta, and about 10 Latin American countries would not endorse passages on sexuality, defense of life, and anything which might condone abortion. About 12 Islamic states opposed all references which may authorize premarital and extramarital sexual intercourse and sex education for adolescents. Another problem which held the attention of the delegates was family regrouping of immigrants in host countries. Most Western countries wanted the word ¿rights' removed from that part of the action plan addressing family regrouping of immigrants. Even though several developing countries are dissatisfied with immigration problems, they do not want to limit family regrouping. Delegates sanctioned US$ 17 billion to be dispersed for family planning in developing countries by 2000, but who will donate these funds? The controversy over abortion and sexuality made delegates forget to address the environment and development. Since 1992, pressure by nongovernmental organizations (NGOs) has forced development out of the economic sphere. NGOs stress the importance of the social dimension of development in developing countries. The debate on poverty, which was supposed to occur in Cairo, did not take place. According to many NGOs and representatives from developing countries, the conference spent 10 days on abortion and only 10 minutes on development. NGOs disapproved of the relegation of human development problems and structural adjustment problems to the background. Developing countries wanted to discuss foreign aid and the inequalities between rich and poor countries. By 2000, there will be 300 million more poor persons. Several delegates from developed countries conceded that their governments would reorient foreign aid to family planning programs in developing countries. Have they forgotten that development is an essential condition for slowing population growth, which is what they want? PMID:12179394

  17. Single Institution Feasibility Trials - Cancer Imaging Program

    Science.gov (United States)

    Within the CIP program, the current R21 mechanism provides potential funding for small, single institution feasibility trials. The current announcement is titled In Vivo Cancer Imaging Exploratory/Developmental Grants.

  18. 78 FR 20118 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-04-03

    ... Committee: National Cancer Institute Special Emphasis Panel; Cancer Biology and Therapy. Date: April 17... Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  19. 78 FR 25459 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-05-01

    ... Committee: National Cancer Institute Special Emphasis Panel; Cancer Therapy (Omnibus). Date: June 27-28....395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  20. 75 FR 20370 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2010-04-19

    ....395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93...@mail.nih.gov . Name of Committee: National Cancer Institute Special Emphasis Panel, Breast Cancer... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  1. Reducing cancer health disparities: Perspective of the National Cancer Institute

    OpenAIRE

    Chu, Kenneth C.; Hubbell, F. Allan

    2008-01-01

    The National Cancer Institute created the Special Population Network (SPN) to develop cancer awareness, research and training with partnerships from community and research organizations. This paper provides background information about the Pacific Islander Cancer Control Network, one of the SPNs, and about the seven research projects that are described in this Supplement.

  2. The view from Cairo.

    Science.gov (United States)

    Wangh, L J

    1995-01-01

    The author, a Brandeis University biologist who attended the 1994 International Conference on Population and Development, cautions against optimism regarding the global impact of this gathering in the absence of revolutionary changes in four areas: reproductive practices, sexual behavior, human consumption of natural resources, and population crowding. Few speakers at Cairo addressed the ecologic and climatologic consequences of overpopulation and environmental destruction, despite indications that the earth is reaching the limits of its environmental support system. Another concern is the conflict between contraceptive methods that are most effective in preventing pregnancy and the condom use that is essential to halt the spread of acquired immunodeficiency syndrome (AIDS). In countries such as China, where the AIDS epidemic's threat has been minimized by the government, massive educational campaigns will be required to convince sterilized couples that they must now practice safe sex. Also criticized is the assumption that population stabilization is achievable through a balance in birth and death rates. It is likely that environmental instability and other factors will lead to substantially increased mortality in the years ahead. Needed is a new global ethics based on biological realities and valuation of the environment. PMID:12319267

  3. Breast Cancer: Surgery at the South Egypt Cancer Institute

    OpenAIRE

    Salem, Ahmed A.S.; Mohamed Abou Elmagd Salem; Hamza Abbass

    2010-01-01

    Breast cancer is the most frequent malignant tumor in women worldwide. In Egypt, it is the most common cancer among women, representing 18.9% of total cancer cases (35.1% in women and 2.2% in men) among the Egypt National Cancer Institute’s (NCI) series of 10,556 patients during the year 2001, with an age-adjusted rate of 49.6 per 100,000 people. In this study, the data of all breast cancer patients presented to the surgical department of the South Egypt cancer Institute (SECI) hospital durin...

  4. 77 FR 67015 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2012-11-08

    ... Committee: National Cancer Institute Special Emphasis Panel NCI Omnibus and Cancer Therapy. Date: November... Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  5. 78 FR 8157 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-02-05

    ... Committee: National Cancer Institute Special Emphasis Panel; Provocative Questions: Cancer Therapy and... Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  6. 78 FR 36200 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-06-17

    ... Committee: National Cancer Institute Special Emphasis Panel; Cancer Biology and Therapy. Date: June 24, 2013... Research; 93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  7. 78 FR 59362 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-09-26

    ... Committee: National Cancer Institute Special Emphasis Panel Provocative Questions--Group D: Cancer Therapy... Research; 93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  8. 78 FR 50065 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-08-16

    ...@mail.nih.gov . Name of Committee: National Cancer Institute Special Emphasis Panel; Cancer Therapy... Prevention Research; 93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  9. 76 FR 50487 - National Cancer Institute Notice of Closed Meetings

    Science.gov (United States)

    2011-08-15

    ... Committee: National Cancer Institute Special Emphasis Panel; NCI SPORE in Childhood ALL, Skin, Brain, Lung....395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93... HUMAN SERVICES National Institutes of Health National Cancer Institute Notice of Closed...

  10. 76 FR 576 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2011-01-05

    ...-Therapy Breast Cancer Patients. Date: March 3, 2011. Time: 12 p.m. to 5 p.m. Agenda: To review and....395, Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  11. 78 FR 27408 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-05-10

    ... Methods for the Detection of Cancer Recurrence in Post-Therapy Breast Cancer Patients. Date: June 4, 2013... Prevention Research; 93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  12. 78 FR 58321 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-09-23

    ... Emphasis Panel, Provocative Questions: Cancer Therapy & Outcomes. Date: November 7-8, 2013. Time: 8:00 a.m..., Cancer Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93.398... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  13. 75 FR 21002 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2010-04-22

    ...; 93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer... Panel, SPORE in Lymphoma and Breast Cancer. Date: June 15-16, 2010. Time: 5 p.m. to 5 p.m. Agenda: To... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  14. 75 FR 3239 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2010-01-20

    ... Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93.398, Cancer Research... Special Emphasis Panel, Basal-like Breast Cancer Assay. Date: March 10, 2010. Time: 8 a.m. to 7 p.m... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  15. Institutional shared resources and translational cancer research.

    Science.gov (United States)

    De Paoli, Paolo

    2009-01-01

    The development and maintenance of adequate shared infrastructures is considered a major goal for academic centers promoting translational research programs. Among infrastructures favoring translational research, centralized facilities characterized by shared, multidisciplinary use of expensive laboratory instrumentation, or by complex computer hardware and software and/or by high professional skills are necessary to maintain or improve institutional scientific competitiveness. The success or failure of a shared resource program also depends on the choice of appropriate institutional policies and requires an effective institutional governance regarding decisions on staffing, existence and composition of advisory committees, policies and of defined mechanisms of reporting, budgeting and financial support of each resource. Shared Resources represent a widely diffused model to sustain cancer research; in fact, web sites from an impressive number of research Institutes and Universities in the U.S. contain pages dedicated to the SR that have been established in each Center, making a complete view of the situation impossible. However, a nation-wide overview of how Cancer Centers develop SR programs is available on the web site for NCI-designated Cancer Centers in the U.S., while in Europe, information is available for individual Cancer centers. This article will briefly summarize the institutional policies, the organizational needs, the characteristics, scientific aims, and future developments of SRs necessary to develop effective translational research programs in oncology.In fact, the physical build-up of SRs per se is not sufficient for the successful translation of biomedical research. Appropriate policies to improve the academic culture in collaboration, the availability of educational programs for translational investigators, the existence of administrative facilitations for translational research and an efficient organization supporting clinical trial recruitment

  16. Institutional shared resources and translational cancer research

    Directory of Open Access Journals (Sweden)

    De Paoli Paolo

    2009-06-01

    Full Text Available Abstract The development and maintenance of adequate shared infrastructures is considered a major goal for academic centers promoting translational research programs. Among infrastructures favoring translational research, centralized facilities characterized by shared, multidisciplinary use of expensive laboratory instrumentation, or by complex computer hardware and software and/or by high professional skills are necessary to maintain or improve institutional scientific competitiveness. The success or failure of a shared resource program also depends on the choice of appropriate institutional policies and requires an effective institutional governance regarding decisions on staffing, existence and composition of advisory committees, policies and of defined mechanisms of reporting, budgeting and financial support of each resource. Shared Resources represent a widely diffused model to sustain cancer research; in fact, web sites from an impressive number of research Institutes and Universities in the U.S. contain pages dedicated to the SR that have been established in each Center, making a complete view of the situation impossible. However, a nation-wide overview of how Cancer Centers develop SR programs is available on the web site for NCI-designated Cancer Centers in the U.S., while in Europe, information is available for individual Cancer centers. This article will briefly summarize the institutional policies, the organizational needs, the characteristics, scientific aims, and future developments of SRs necessary to develop effective translational research programs in oncology. In fact, the physical build-up of SRs per se is not sufficient for the successful translation of biomedical research. Appropriate policies to improve the academic culture in collaboration, the availability of educational programs for translational investigators, the existence of administrative facilitations for translational research and an efficient organization

  17. Meeting the challenge of Cairo.

    Science.gov (United States)

    Maguire, E

    1998-09-01

    The US Agency for International Development (USAID) has been actively involved in endorsing and achieving the 20-year Program of Action set by the 180 participating countries at the Cairo conference. This Program of Action was designed to achieve gender equality, improved reproductive health, and population stabilization as well as a wide range of sustainable development goals. Being the largest bilateral donor of population and health assistance, USAID has played a particularly crucial role in helping countries implement the core objectives of Cairo in family planning, maternal health, the prevention of HIV/AIDS and other sexually transmitted infections, and other aspects of reproductive health. By providing technical leadership and working in collaboration with universities, nongovernmental organizations, private businesses, and other government agencies, the USAID through the programs it funds provides a wide variety of expertise to assist other countries so that they can effectively carry out their respective reproductive health programs of action. PMID:12322268

  18. Copenhagen−Cairo on a roundtrip

    DEFF Research Database (Denmark)

    Greenwood, Maja Touzari Janesdatter; Wæver, Ole

    2013-01-01

    Although securitization theory has been applied worldwide, it has been accused of having only limited appositeness to the non-Western world. When the Centre for Advanced Security Theory began a collaboration with the Danish–Egyptian Dialogue Institute and the Al-Ahram Centre for Political and...... Strategic Studies in Cairo in 2010, securitization theory was challenged on two levels: both through its employment to analyse and act politically in a Middle Eastern context, and through the attempt to do so during and after the Arab Spring, when the entire Egyptian security sector was being re......-evaluated. These unique circumstances prompted reflections on the use of non-traditional and traditional security concepts, on how the Egyptian revolution could be understood through securitization theory, and on what the experiences of this project might mean for further theory development. This article discusses...

  19. Assessment of diagnosis of inflammatory breast cancer cases at two cancer centers in Egypt and Tunisia

    OpenAIRE

    Schairer, Catherine; Soliman, Amr S; Omar, Sherif; Khaled, Hussein; Eissa, Saad; Ayed, Farhat Ben; Khalafallah, Samir; Ayoub, Wided Ben; Kantor, Elizabeth D.; Merajver, Sofia; Swain, Sandra M; Gail, Mitchell; Brown, Linda Morris

    2013-01-01

    The diagnosis of inflammatory breast cancer (IBC) is largely clinical and therefore inherently somewhat subjective. The objective of this study was to evaluate the diagnosis of IBC at two centers in North Africa where a higher proportion of breast cancer is diagnosed as IBC than in the United States (U.S.). Physicians prospectively enrolled suspected IBC cases at the National Cancer Institute (NCI) – Cairo, Egypt, and the Institut Salah Azaiz (ISA), Tunisia, recorded extent and duration of si...

  20. 78 FR 50064 - National Cancer Institute; Notice of Meeting

    Science.gov (United States)

    2013-08-16

    ...: 8:30 a.m. to 3:30 p.m. Agenda: Cancer Communication for Prevention: In the Digital Commons... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Meeting Pursuant to... a meeting of the President's Cancer Panel. The meeting will be open to the public, with...

  1. 78 FR 69432 - National Cancer Institute; Notice of Meeting

    Science.gov (United States)

    2013-11-19

    ...:30 a.m. to 4:00 p.m. Agenda: Cancer Communication in the Digital Era: Opportunities and Challenges... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Meeting Pursuant to... a meeting of the President's Cancer Panel. The meeting will be open to the public, with...

  2. 78 FR 53154 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-08-28

    ... Prevention Research; 93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93... Emphasis Panel NCI Experimental Therapeutics--Clinical Trials Network with Phase 1 Emphasis. Date: November... HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed...

  3. Nutritional profile of pediatric cancer patients at Cancer Institute, Chennai

    Directory of Open Access Journals (Sweden)

    V Radhakrishnan

    2015-01-01

    Full Text Available Background: Malnutrition is widely prevalent in the pediatric population in India. There is paucity of data on the prevalence of malnutrition in pediatric cancer patients and the impact of cancer treatment on nutritional status of Indian children. Aims: The study was conducted to look at the prevalence of malnutrition and assess the impact of treatment on nutritional status of pediatric cancer patients. Settings And Design: This was a retrospective study. Materials And Methods: Data on the weight of pediatric cancer patients <16 years of age treated at Cancer Institute, Chennai, from January 2013 to May 2014 were analyzed at systematic time points in therapy. Patients' weight were plotted on the Centre for Disease Control (CDC growth charts. Patients were defined to be undernourished if their weight for age was ≤3rd centile in CDC growth charts and obese if their weight for age was ≥97th centile on CDC growth charts. RESULTS: A total of 295 patient case records were analyzed. Acute lymphoblastic leukemia was the most common malignancy. At diagnosis, under-nutrition was seen in 44% patients, this increased to 46% midway during treatment (end of induction in acute leukemia and completion of 50% of planned treatment in solid tumors and decreased to 27% at the end of treatment (beginning of maintenance in acute leukemia and completion of planned treatment in solid tumors (P = 0.0005. There was no significant difference in nutritional status between patients with hematological malignancies and solid tumors (P = 0.8. Conclusion: Under-nutrition is present in close to half of the pediatric cancer patients presenting to our institute. Active nutritional intervention and education were able to significantly reduce the prevalence of under-nutrition in patients at the end of treatment.

  4. 78 FR 36201 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-06-17

    ... new diagnostics for cancer. Place: National Cancer Institute, 9609 Medical Center Drive, Room 2W908... meeting is to evaluate requests for development resources for potential new cancer diagnostics. The... of the potential diagnostics to improve the treatment of cancer. The research proposals and...

  5. Cost and Outcome of Treatment of Adults with Acute Myeloid Leukemia at the National Cancer Institute-Egypt

    International Nuclear Information System (INIS)

    Despite important advances in the therapy of acute myeloid leukemia (AML), the majority of patients die of their disease, unless bone marrow transplantation (BMT) is done. Infection and hemorrhage are still the major causes of mortality in AML patients. Progress in therapy and supportive care has led to gradual improvement in the overall results, but further improvements are still needed. Patients and Methods: The aim of this study is to identify the outcome and costs of adult AML patients treated with conventional chemotherapy (CCT) at the National Cancer Institute (NCI), Cairo University during the time period from April 1999 to January 2002. Clinical, laboratory characteristics were all recorded. Data regarding different types of therapies given for these patients including response, outcome and costs were also collected. Results: The median age of 82 identified AML patients was 34 years. The complete remission (CR) rate after induction with CCT was 52% (42/82 patients) with a median CR duration of 9 months. Twenty-eight percent of patients who achieved CR subsequently relapsed. By January 2003, fifty-eight patients were dead (70.7%). Infections were the major mortality cause, followed by disease progression then bleeding (65%, 28% and 7% respectively). The median treatment cost per patient was 33158 Egyptian Pounds (LE). It was higher for patients who achieved CR compared to those who relapsed and/or died. Drugs contributed by 78 % to the total treatment cost, while hospitalization, investigations and blood-component therapy contributed by 6%, 7% and 8% respectively. Conclusions: Outcome of patients with AML treated at NCI- Cairo University can be enhanced by improvement of supportive therapy; mainly infection control and expanding BMT programs to accommodate all eligible patients

  6. Upgrading Downtown Cairo towards friendly mobility

    OpenAIRE

    Nunes, Joao; Zoilo, Inaki; Torres-Campos, Tiago; Sanz, Berta

    2011-01-01

    This paper addresses the challenge of proposing new standards in Downtown Cairo towards innovative, friendlier and more sustainable mobility.Cairo emerges as one of the main Mediterranean megalopolis, with fundamental geo-positions at national, regional and global levels. Over the last decades, the city has been growing more rapidly than its infrastructural and mobility services, and most attempts to correct its mobility systems may have arrived too late, sometimes even with serious environme...

  7. Probabilistic earthquake hazard analysis for Cairo, Egypt

    Science.gov (United States)

    Badawy, Ahmed; Korrat, Ibrahim; El-Hadidy, Mahmoud; Gaber, Hanan

    2016-04-01

    Cairo is the capital of Egypt and the largest city in the Arab world and Africa, and the sixteenth largest metropolitan area in the world. It was founded in the tenth century (969 ad) and is 1046 years old. It has long been a center of the region's political and cultural life. Therefore, the earthquake risk assessment for Cairo has a great importance. The present work aims to analysis the earthquake hazard of Cairo as a key input's element for the risk assessment. The regional seismotectonics setting shows that Cairo could be affected by both far- and near-field seismic sources. The seismic hazard of Cairo has been estimated using the probabilistic seismic hazard approach. The logic tree frame work was used during the calculations. Epistemic uncertainties were considered into account by using alternative seismotectonics models and alternative ground motion prediction equations. Seismic hazard values have been estimated within a grid of 0.1° × 0.1 ° spacing for all of Cairo's districts at different spectral periods and four return periods (224, 615, 1230, and 4745 years). Moreover, the uniform hazard spectra have been calculated at the same return periods. The pattern of the contour maps show that the highest values of the peak ground acceleration is concentrated in the eastern zone's districts (e.g., El Nozha) and the lowest values at the northern and western zone's districts (e.g., El Sharabiya and El Khalifa).

  8. 75 FR 16488 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-04-01

    ... the treatment of cancer. The outcome of the evaluation will provide information to internal NCI... development of the potential therapeutic to improve the treatment of various forms of cancer. The research... of Committee: National Cancer Institute Special Emphasis Panel; NCI Experimental Therapeutics...

  9. 75 FR 60132 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-09-29

    ... the treatment of cancer. The outcome of the evaluation will provide information to internal NCI... development of the potential therapeutic to improve the treatment of various forms of cancer. The research... of Committee: National Cancer Institute Special Emphasis Panel; NCI Experimental Therapeutics...

  10. 76 FR 42719 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-07-19

    ... the treatment of cancer. The outcome of the evaluation will provide information to internal NCI... development of the potential therapeutic to improve the treatment of various forms of cancer. The research... of Committee: National Cancer Institute Special Emphasis Panel, NCI Experimental Therapeutics...

  11. 77 FR 43098 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2012-07-23

    ... the treatment of cancer. The outcome of the evaluation will provide information to internal NCI... development of the potential therapeutic to improve the treatment of various forms of cancer. The research... of Committee: National Cancer Institute Special Emphasis Panel; NCI Experimental Therapeutics...

  12. 76 FR 10381 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-02-24

    ... the treatment of cancer. The outcome of the evaluation will provide information to internal NCI... development of the potential therapeutic to improve the treatment of various forms of cancer. The research... of Committee: National Cancer Institute Special Emphasis Panel; NCI Experimental Therapeutics...

  13. 77 FR 15782 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2012-03-16

    ... the treatment of cancer. The outcome of the evaluation will provide information to internal NCI... development of the potential therapeutic to improve the treatment of various forms of cancer. The research.... ] Name of Committee: National Cancer Institute Special Emphasis Panel NCI Experimental...

  14. 75 FR 33817 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-06-15

    ... the treatment of cancer. The outcome of the evaluation will provide information to internal NCI... development of the potential therapeutic to improve the treatment of various forms of cancer. The research... of Committee: National Cancer Institute Special Emphasis Panel; NCI Experimental Therapeutics...

  15. 76 FR 66733 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-10-27

    ... the treatment of cancer. The outcome of the evaluation will provide information to internal NCI... development of the potential therapeutic to improve the treatment of various forms of cancer. The research... of Committee: National Cancer Institute Special Emphasis Panel, NCI Experimental Therapeutics...

  16. Selected National Cancer Institute Breast Cancer Research Topics | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... For Breast Cancer Selected National Cancer Institute Breast Cancer Research Topics Past Issues / Summer 2014 Table of Contents ... Trials www.cancer.gov/clinicaltrials/Taking-Part-in-Cancer-Treatment-Research-Studies MedlinePlus tutorial www.nlm.nih.gov/medlineplus/ ...

  17. 76 FR 1625 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-01-11

    ... Committee: National Cancer Institute Initial Review Group; Subcommittee I--Career Development, Career Development. Date: February 22-23, 2011. Time: February 22, 2011, 8 a.m. to 6 p.m. Agenda: To review...

  18. 75 FR 48699 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-08-11

    ... Committee: National Cancer Institute Initial Review Group, Subcommittee I--Career Development, NCI-I Career Development. Date: September 21, 2010. Time: 8 a.m. to 6 p.m. Agenda: To review and evaluate...

  19. Dana-Farber Cancer Institute | Office of Cancer Genomics

    Science.gov (United States)

    Functional Annotation of Cancer Genomes Principal Investigator: William C. Hahn, M.D., Ph.D. The comprehensive characterization of cancer genomes has and will continue to provide an increasingly complete catalog of genetic alterations in specific cancers. However, most epithelial cancers harbor hundreds of genetic alterations as a consequence of genomic instability. Therefore, the functional consequences of the majority of mutations remain unclear.

  20. Imaging woman in the streets of Cairo. Analyses of Cairo graffiti

    OpenAIRE

    Zakarevičiūtė, Ieva

    2013-01-01

    Thesis analyses imaging of women in the Cairo graffiti field that emerged after 2011 January 25 revolution. Author raises and argument that Cairo graffiti is not only a romanticized and heroic space created as genre of freedom of expression and used as a struggle against changing political systems in Egypt, but rather a pluralistic public sphere where different opinions, ideas and arguments are emerging. Thesis distinguishes major archetypes used as predominant images of women, it analyses wh...

  1. Intermediate evaluation of USAID/Cairo energy policy planning project

    Energy Technology Data Exchange (ETDEWEB)

    Wilbanks, T.J.; Wright, S.B. [Oak Ridge National Lab., TN (United States); Barron, W.F. [Hong Kong Univ. (Hong Kong); Kamel, A.M. [Ain Shams Univ., Cairo (Egypt); Santiago, H.T. [USDOE, Washington, DC (United States)

    1992-09-01

    Three years ago, a team from the Oak Ridge National Laboratory and the Oak Ridge Associated Universities, supplemented by an expert from the US Department of Energy and a senior Egyptian energy professional, carried out what was termed an ``intermediate evaluation`` of a major energy policy project in Egypt. Supported by USAID/Cairo, the project had concentrated on developing and strengthening an Organization for Energy Planning (OEP) within the Government of India, and it was actually scheduled to end less than a year after this evaluation. The evaluation was submitted to USAID/Cairo and circulated elsewhere in the US Agency for International Development and the Government of Egypt as an internal report. Over the next several years, the USAID energy planning project ended and the functions performed by OEP were merged with planning capabilities in the electric power sector. Now that the major issues addressed by the evaluation report have been resolved, we are making it available to a broader audience as a contribution to the general literature on development project evaluation and institution-building.

  2. Intermediate evaluation of USAID/Cairo energy policy planning project

    Energy Technology Data Exchange (ETDEWEB)

    Wilbanks, T.J.; Wright, S.B. (Oak Ridge National Lab., TN (United States)); Barron, W.F. (Hong Kong Univ. (Hong Kong)); Kamel, A.M. (Ain Shams Univ., Cairo (Egypt)); Santiago, H.T. (USDOE, Washington, DC (United States))

    1992-01-01

    Three years ago, a team from the Oak Ridge National Laboratory and the Oak Ridge Associated Universities, supplemented by an expert from the US Department of Energy and a senior Egyptian energy professional, carried out what was termed an intermediate evaluation'' of a major energy policy project in Egypt. Supported by USAID/Cairo, the project had concentrated on developing and strengthening an Organization for Energy Planning (OEP) within the Government of India, and it was actually scheduled to end less than a year after this evaluation. The evaluation was submitted to USAID/Cairo and circulated elsewhere in the US Agency for International Development and the Government of Egypt as an internal report. Over the next several years, the USAID energy planning project ended and the functions performed by OEP were merged with planning capabilities in the electric power sector. Now that the major issues addressed by the evaluation report have been resolved, we are making it available to a broader audience as a contribution to the general literature on development project evaluation and institution-building.

  3. Institutional shared resources and translational cancer research

    OpenAIRE

    De Paoli Paolo

    2009-01-01

    Abstract The development and maintenance of adequate shared infrastructures is considered a major goal for academic centers promoting translational research programs. Among infrastructures favoring translational research, centralized facilities characterized by shared, multidisciplinary use of expensive laboratory instrumentation, or by complex computer hardware and software and/or by high professional skills are necessary to maintain or improve institutional scientific competitiveness. The s...

  4. 78 FR 27974 - Proposed Collection; 60-Day Comment Request: National Cancer Institute (NCI) Alliance for...

    Science.gov (United States)

    2013-05-13

    ... Cancer Institute (NCI) Alliance for Nanotechnology in Cancer Platform Partnership Scientific Progress... Partnerships (CNPP) awarded by the National Cancer Institute (NCI). The CNPPs are part of the Alliance for... trans-Alliance collaboration, scientific milestones, progress towards clinical translation...

  5. New Hires at the National Cancer Institute at Frederick | Poster

    Science.gov (United States)

    Fifty-one people joined the facility in November and December 2013. The National Cancer Institute welcomes… Emily Boward Emad Darvishi Shuo Gu Sanath Kumar Janaka Robert Kortum Yasmin Lachir Jinbian Liu Yang Liu Eric Ramirez Salazar Brett Shelley Li Xia Jaeho Yoon

  6. The Regina Elena National Cancer Institute process of accreditation according to the standards of the Organisation of European Cancer Institutes.

    Science.gov (United States)

    Canitano, Stefano; Di Turi, Annunziata; Caolo, Giuseppina; Pignatelli, Adriana C; Papa, Elena; Branca, Marta; Cerimele, Marina; De Maria, Ruggero

    2015-12-31

    The accreditation process is, on the one hand, a tool used to homogenize procedures, rendering comparable and standardized processes of care, and on the other, a methodology employed to develop a culture of quality improvement. Although not yet proven by evidence-based studies that health outcomes improve as a result of an accreditation to excellence, it is undeniable that better control of healthcare processes results in better quality and safety of diagnostic and therapeutic pathways. The Regina Elena National Cancer Institute underwent the accreditation process in accordance with the standards criteria set by the Organisation of European Cancer Institutes (OECI), and it has recently completed the process, acquiring its designation as a Comprehensive Cancer Center (CCC). This was an invaluable opportunity for the Regina Elena Institute to create a more cohesive environment, to widely establish a culture of quality, to implement an institutional information system, and to accelerate the process of patient involvement in strategic decisions. The steps of the process allowed us to evaluate the performance and the organization of the institute and put amendments in place designed to be adopted through 26 improvement actions. These actions regarded several aspects of the institute, including quality culture, information communication technology system, care, clinical trials unit, disease management team, nursing, and patient empowerment and involvement. Each area has a timeline. We chose to present the following 3 improvement actions: clinical trial center, computerized ambulatory medical record, and centrality of patient and humanization of clinical pathway. PMID:27096274

  7. Seismic hazard assessments at Islamic Cairo, Egypt

    Science.gov (United States)

    Khalil, A. E.; Deif, A.; Abdel Hafiez, H. E.

    2015-12-01

    Islamic Cairo is one of the important Islamic monumental complexes in Egypt, near the center of present-day metropolitan Cairo. The age of these buildings is up to one thousand years. Unfortunately, many of the buildings are suffering from huge mishandling that may lead to mass damage. Many buildings and masjids were partially and totally collapsed because of 12th October 1992 Cairo earthquake that took place at some 25 km from the study area with a magnitude Mw = 5.8. Henceforth, potential damage assessments there are compulsory. The deterministic and probabilistic techniques were used to predict the expected future large earthquakes' strong-motion characteristics in the study area. The current study started with compiling the available studies concerned with the distribution of the seismogenic sources and earthquake catalogs. The deterministic method is used to provide a description of the largest earthquake effect on the area of interest, while the probabilistic method, on the other hand, is used to define the uniform hazard curves at three time periods 475, 950, 2475 years. Both deterministic and probabilistic results were obtained for bedrock conditions and the resulted hazard levels were deaggregated to identify the contribution of each seismic source to the total hazard. Moreover, the results obtained show that the expected seismic activities combined with the present situation of the buildings pose high alert to rescue both the cultural heritage and expected human losses.

  8. Gastrointestinal Tumor Board: An Evolving Experience in Tehran Cancer Institute

    Directory of Open Access Journals (Sweden)

    Peiman Haddad

    2013-04-01

    Full Text Available Gastrointestinal (GI cancers are a significant source of morbidity and mortality in Iran, with stomach adenocarcinoma as the most common cancer in men and the second common cancer in women. Also, some parts of Northern Iran have one of the highest incidences of esophageal cancer in the world. Multi-disciplinary organ-based joint clinics and tumor boards are a well-recognized necessity for modern treatment of cancer and are routinely utilized in developed countries, especially in major academic centres. But this concept is relatively new in developing countries, where cancer treatment centres are burdened by huge loads of patients and have to cope with a suboptimum availability of resources and facilities. Cancer Institute of Tehran University of Medical Sciences is the oldest and the only comprehensive cancer treatment centre in Iran, with a long tradition of a general tumor board for all cancers. But with the requirements of modern oncology, there has been a very welcome attention to sub-specialized organ-based tumor boards and joint clinics here in the past few years. Considering this, we started a multi-disciplinary tumor board for GI cancers in our institute in early 2010 as the first such endeavor here. We hereby review this 2-year evolving experience. The process of establishment of a GI tumor board, participations from different oncology disciplines and related specialties, the cancers presented and discussed in the 2 years of this tumor board, the general intents of treatment for the decisions made and the development of interest in this tumor board among the Tehran oncology community will be reviewed. The GI tumor board of Tehran Cancer Institute started its work in January 2010, with routine weekly sessions. A core group of 2 physicians from each surgical, radiation and medical oncology departments plus one gastroenterologist, GI pathologist and radiologist was formed, but participation from all interested physicians was encouraged. An

  9. New Cancer Prevention and Control Central Institutional Review Board Established | Division of Cancer Prevention

    Science.gov (United States)

    The NCI Central Institutional Review Board (CIRB) Initiative announced the establishment of the Cancer Prevention and Control (CPC) CIRB January 14, extending the benefits of centralized review to investigators participating in clinical trials sponsored by the Division of Cancer Prevention (DCP). |

  10. Psychiatric Morbidity among a Sample of Orphanage Children in Cairo

    Directory of Open Access Journals (Sweden)

    Mohamed A. EL Koumi

    2012-01-01

    Full Text Available Objective. This study identifies the prevalence of emotional and behavioral problems and the associated factors in orphanage children. Methods. This cross-sectional study was conducted in three private orphanages in Cairo. Two hundred sixty-five children of ages ranging from 6 to 12 years living in three different orphanages care systems were included in the study. A sociodemographic information form and the Child Behavior Checklist (CBCL were used. Children were clinically interviewed and psychiatric disorders were identified. Diagnoses were done according to the manual for diagnosis and statistics of mental disorder fourth version (DSMIV. A written formal consent from the director of social solidarity was obtained before inclusion in the study. Results. The prevalence of behavioral disturbances was 64.53% among those in institutional care and the most prominent psychiatric disorders were nocturnal enuresis (23.3%, attention deficit hyperkinetic disorder (ADHD (19.62%, oppositional defiant disorder (17.36%. Age at first admission, causes of receiving institutional care, and moves 2 or more times between institutions were significantly associated with an increased risk of behavioral and emotional problems. Conclusion. Our study showed that children living in institutions are prone to suffer from psychiatric disorders. Stability of the caregiver acts as a protective variable.

  11. Accuracy of fine needle aspiration cytology in the diagnosis of bone lesions with radiological assistance: Experience from the National Cancer Institute, Cairo University, Egypt

    OpenAIRE

    Ahmed Mohamed Aly; Hebatallah M. Shaaban; Iman Abou-Sinna

    2014-01-01

    Aim: To evaluate the accuracy of fine needle aspiration cytology in the diagnosis of bone lesions with radiological assistance. Patients and methods: 85 cases of FNAC of bone lesions were included. Sixty two procedures were performed by the radiologist and 23 procedures by the histopathologists. The aspirates were immediately fixed in 95% ethanol alcohol for Papanicolaou staining. If there was sufficient material, cell block was prepared. Diagnosis was established in 81 cases (95.3%), clas...

  12. Understanding and Reducing Obstacles in a Collaboration between a Minority Institution and a Cancer Center

    OpenAIRE

    Thompson, Beti; O’Connell, Mary; Löest, Helena; Anderson, Jennifer; Westcott, Rick

    2013-01-01

    Reducing the cancer incidence and mortality rates of underserved populations will require multidisciplinary efforts involving teams of diverse investigators. We describe a collaborative program between a National Cancer Institute-designated cancer center and a minority-serving institution. The organizations worked together to discover institutional and cultural barriers and facilitators to productive collaboration.

  13. Northeast Regional Cancer Institute's Cancer Surveillance and Risk Factor Program

    Energy Technology Data Exchange (ETDEWEB)

    Lesko, Samuel M.

    2007-07-31

    OBJECTIVES The Northeast Regional Cancer Institute is conducting a program of ongoing epidemiologic research to address cancer disparities in northeast Pennsylvania. Of particular concern are disparities in the incidence of, stage at diagnosis, and mortality from colorectal cancer. In northeast Pennsylvania, age-adjusted incidence and mortality rates for colorectal cancer are higher, and a significantly smaller proportion of new colorectal cancer cases are diagnosed with local stage disease than is observed in comparable national data. Further, estimates of the prevalence of colorectal cancer screening in northeast Pennsylvania are lower than the US average. The Northeast Regional Cancer Institute’s research program supports surveillance of common cancers, investigations of cancer risk factors and screening behaviors, and the development of resources to further cancer research in this community. This project has the following specific objectives: I. To conduct cancer surveillance in northeast Pennsylvania. a. To monitor incidence and mortality for all common cancers, and colorectal cancer, in particular, and b. To document changes in the stage at diagnosis of colorectal cancer in this high-risk, underserved community. II. To conduct a population-based study of cancer risk factors and screening behavior in a six county region of northeast Pennsylvania. a. To monitor and document changes in colorectal cancer screening rates, and b. To document the prevalence of cancer risk factors (especially factors that increase the risk of colorectal cancer) and to identify those risk factors that are unusually common in this community. APPROACH Cancer surveillance was conducted using data from the Northeast Regional Cancer Institute’s population-based Regional Cancer Registry, the Pennsylvania Cancer Registry, and NCI’s SEER program. For common cancers, incidence and mortality were examined by county within the region and compared to data for similar populations in the US

  14. Report on the third meeting of the project advisory committee (technical) for IAEA/WHO Project EGY/6/004 (Egyptian Cancer Project) 27-29 April 1985, at NEMROCK, Cairo. PACT(3)

    International Nuclear Information System (INIS)

    The Project was launched in March 1983, with the first meeting of the Committee (PACT(I)). It was planned for a duration of four years. Now, after two years experience, PACT(III) met to review results so far and to advise on actions for the remaining two years. Appendix 1 lists those present at the meeting. Since 1983 a Pilot Project has been running at NEMROCK, the Nuclear Medicine and Radiation Oncology Centre at Cairo University Hospital, at which the Project is based. Two training courses have been given, in November 1983 and November 1984, and treatment has been given using protocols developed under the project. PACT(III) examined clinical results obtained so far and made recommendations for the extension of the scheme to other hospitals in Egypt

  15. Cooperative research and development opportunities with the National Cancer Institute

    Science.gov (United States)

    Sybert, Kathleen

    1991-01-01

    The Office of Technology Development (OTD) of the National Cancer Institute (NCI) is responsible for negotiating Cooperative Research and Development Agreements (CRADAs), whereby the knowledge resulting from NCI investigators' government-sponsored research is developed in collaboration with universities and/or industry into new products of importance for the diagnosis and treatment of cancer and acquired immunodeficiency syndrome (AIDS). The NCI has recently executed a unique 'clinical trials' CRADA and is developing a model agreement based upon it for the development and commercialization of products for the diagnosis and treatment of cancer and AIDS. NCI drug screening, preclinical testing, clinical trials, and AIDS program capabilities form the basis for this new technology development/technology transfer vehicle. NCI's extensive drug screening program and 'designer foods' program serve as potential sources of investigational new drugs (INDs) and cancer preventatives. Collaborations between NCI and pharmaceutical companies having the facilities, experience, and expertise necessary to develop INDs into approved drugs available to the public are being encouraged where the companies have proprietary rights to INDs, or where NCI has proprietary rights to INDs and invites companies to respond to a collaborator announcement published in the Federal Register. The joint efforts of the NCI and the chosen collaborator are designed to generate the data necessary to obtain pharmaceutic regulatory approval from the Food and Drug Administration (FDA) to market the drugs developed, and thereby make them available to health care providers for the diagnosis and treatment of cancer and AIDS.

  16. Optimizing pain care delivery in outpatient facilities: experience in NCI, Cairo, Egypt.

    Science.gov (United States)

    Hameed, Khaled Abdel

    2011-04-01

    As a result of increasing waiting lists of patients attending National Cancer Institute of Cairo, we are faced to provide high-quality pain care service through our outpatient pain clinic. The program description presented here shows the capacity of a 24 hours/7 days outpatient cancer pain management service to provide rapidly accessible, high-quality care to patients with complex pain and palliative care symptom burdens. In addition, this model avoids inpatient hospital admissions. Pain clinics of cancer are committed to helping patients and families identify and implement the treatments necessary to achieve optimum functional ability and the best possible quality of life. These clinics also help to communicate and work with the family physician, surgeon, and other physicians associated with patient treatment. Cancer pain is complex in its causes, and affects all parts of the body. It involves the tissues, body systems , and the mind. Being multidimensional, it is never adequately addressed with unidimensional treatment. Pain management must extend beyond physical approaches to include the psychological, social, and even spiritual aspects of the patient. Effective integrated treatment fosters self awareness and teaches appropriate and effective self care. With time, complex issues are managed, pain is reduced, and the patient moves toward peak physical and psychological functioning. These goals can be achieved by providing the highest quality pain management services. Patients attending the clinic get treated medically for their physical ailments. Their emotional and psychological problems also need to be attended with an atmosphere of love and care. The mission of the highest quality service is to obtain customer satisfaction with reduction of cost in a multidisciplinary (or better interdisciplinary) approach. This can be reached by proper identification of the customers either internal or external, assessing their needs, and implementing plans for their

  17. Cancer complementary and alternative medicine research at the US National Cancer Institute.

    Science.gov (United States)

    Jia, Libin

    2012-05-01

    The United States National Cancer Institute (NCI) supports complementary and alternative medicine (CAM) research which includes different methods and practices (such as nutrition therapies) and other medical systems (such as Chinese medicine). In recent years, NCI has spent around $120 million each year on various CAM-related research projects on cancer prevention, treatment, symptom/side effect management and epidemiology. The categories of CAM research involved include nutritional therapeutics, pharmacological and biological treatments, mind-body interventions, manipulative and body based methods, alternative medical systems, exercise therapies, spiritual therapies and energy therapies on a range of types of cancer. The NCI Office of Cancer Complementary and Alternative Medicine (OCCAM) supports various intramural and extramural cancer CAM research projects. Examples of these cancer CAM projects are presented and discussed. In addition, OCCAM also supports international research projects. PMID:22241505

  18. Demographic pattern of male breast cancer: an institutional based study

    International Nuclear Information System (INIS)

    Background: Male breast cancer incidence rises with age with peak in the sixth and seventh decade. It is one of the rare diseases and accounts for less than 1% of all malignancies worldwide. It is usually diagnosed in the late stage with poor prognosis. Objective: The purpose of this study was to know the demographic pattern and tumour characteristic of breast cancer in men reported at Institute of Radiotherapy and Nuclear Medicine (IRNUM), Peshawar. Methods: Retrospective data was collected from the (IRNUM), Peshawar for a period of three years (2006-2008). The evaluation was done from the histopathological reports of mastectomy and biopsy specimens. All male patients in the age group 26 -86 year with breast cancer were included in the study. The age of the patients and tumour characteristics recorded were size, grade, type, skin involvement and stage. Results: Total number of male patients with breast cancer were 31 (2.1%) out of the total patients with breast malignancy during the study period with the mean age of 58.3 years. Tumour size ranged from 2 to 12 Cm. with average of 3.6 Cm. Invasive ductal carcinoma was found in 87% , papillary carcinoma in 6.5%, each of malignant fibrous histocytoma and sarcoma in 3.2% cases. Maximum number of patients was of grade II (41%). Patients in whom stage of the disease was know n were 22 cases with 45.5% had stage III disease and 32% had stage IV disease. Skin involvement was found positive in 8 (25.8%). Conclusion: Due to poor health care system breast cancer is diagnosed in a late stage of the disease and prognosis is poor. (author)

  19. 75 FR 51830 - National Cancer Institute's Best Practices for Biospecimen Resources

    Science.gov (United States)

    2010-08-23

    ... HUMAN SERVICES National Institutes of Health National Cancer Institute's Best Practices for Biospecimen... best practices, the National Cancer Institute (NCI) is seeking public comment on a revised version of the NCI Best Practices for Biospecimen Resources. This revised version of the NCI Best Practices...

  20. Assembling a Revolution: Graffiti, Cairo and the Arab Spring

    OpenAIRE

    John Lennon

    2014-01-01

    This essay examines the ways revolutionary desire was articulated and interpreted through graffiti in Cairo, Egypt during the Arab Spring and its immediate aftermath. For writers in Cairo, graffiti was one of many in a constellation of resistances that undermined everyday life in Hosni Mubarak’s Egypt and the SCAF-controlled interim government. Ordinary surfaces of the city were illegally marked, displaying revolutionary potentiality by allowing the seemingly powerless rhetorical openings of ...

  1. CPTAC Establishes Formal Relationships with Two Academic Institutions in Taiwan - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC) has entered into memorandum of understandings (MOUs) with Chang Gung University and Academia Sinica, in Taipei, Taiwan.

  2. Statement to commencement ceremony at American University in Cairo (AUC). 9 February 2006, Cairo, Egypt

    International Nuclear Information System (INIS)

    In its statement to Commencement Ceremony At American University in Cairo (AUC) the Director General of the IAEA reminisced about his life - the twists and turns it had taken, and the lessons he had learned along the way. His messages to the students was to keep thinking and learning, be ready for opportunity when it comes, treat others with the understanding that we are all part of one human family, live your own life, and take joy in it, be proud of your heritage and engage fully in the future of Egypt

  3. Characterization of CTX-M ESBLs in Enterobacter cloacae, Escherichia coli and Klebsiella pneumoniae clinical isolates from Cairo, Egypt

    OpenAIRE

    Khalaf Noha G; Eletreby Mona M; Hanson Nancy D

    2009-01-01

    Abstract Background A high rate of resistance to 3rd generation cephalosporins among Enterobacteriaceae isolates from Egypt has been previously reported. This study aims to characterize the resistance mechanism (s) to extended spectrum cephalosporins among resistant clinical isolates at a medical institute in Cairo, Egypt. Methods Nonconsecutive Klebsiella pneumoniae (Kp), Enterobacter cloacae (ENT) and Escherichia coli (EC) isolates were obtained from the clinical laboratory at the medical i...

  4. The national cancer institute (NCI) and cancer biology in a 'post genome world'

    International Nuclear Information System (INIS)

    The National Cancer Institute (NCI) exists to reduce the burden of all cancers through research and discovery. Extensive restructuring of the NCI over the past year has been aimed at assuring that the institution functions in all ways to promote opportunities for discovery in the laboratory, in the clinic, and in the community. To do this well requires the difficult and almost paradoxical problem of planning for scientific discovery which, in turn is based on the freedom to pursue the unanticipated. The intellectual and structural landscape of science is changing and it places new challenges, new demands and new opportunities for facilitating discovery. The nature of cancer as a disease of genomic instability and of accumulated genetic change, coupled with a possibility of the development of new technologies for reading, utilizing, interpreting and manipulating the genome of single cells, provides unprecedented opportunities for a new type of high through-put biology that will change the nature of discovery, cancer detection, diagnosis, prognosis, therapeutic decision-making and therapeutic discovery. To capture these new opportunities will require attention to be paid to integrate the development of technology and new scientific discoveries with the ability to apply advances rapidly and efficiently through clinical trials

  5. 75 FR 992 - National Cancer Institute; Notice of Meeting

    Science.gov (United States)

    2010-01-07

    ... personal privacy. Name of Committee: National Cancer Advisory Board; Ad Hoc Subcommittee on Experimental Therapeutics. Open: February 8, 2010, 6:30 p.m. to 8 p.m. Agenda: Discussion on cancer experimental... Detection and Diagnosis Research; 93.395, Cancer Treatment Research; 93.396, Cancer Biology Research;...

  6. Elasticity of Cmcm CaIrO3

    Science.gov (United States)

    Fujibuchi, M.; Tsuchiya, T.; Tsuchiya, J.

    2006-12-01

    CaIrO3 has the orthorhombic Cmcm crystal structure which is isostructural to the recently discovered high-pressure postperovskite phase of MgSiO3 even at room pressure. Due to the quite high transition pressure of MgSiO3, its low-pressure analog is important to investigate properties of this transition experimentally. Here we performed ab initio calculations of static elasticity of CaIrO3 phases and found that at low pressures, some properties of velocity contrasts between the Pbnm and Cmcm phases, shear wave splitting anisotropy, etc. are very different from those of MgSiO3 at its stable pressures, while they became similar with increasing pressure. This indicates that experiments should be performed under some pressure, even if CaIrO3 is used as the low-pressure analog of MgSiO3. Research supported by Ehime Univ Project Fund, JSPS Grant-in-Aid.

  7. 78 FR 28235 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-05-14

    ... Toolkit for Cancer Diagnosis, Staging, and Treatment. Date: May 29, 2013. Time: 12:00 p.m. to 2:00 p.m... Treatment Research; 93.396, Cancer Biology Research; 93.397, Cancer Centers Support; 93.398, Cancer Research... Diagnostic Assay to Detect Basal- like Breast Cancer. Date: June 13, 2013. Time: 12:00 p.m. to 1:00...

  8. Ahead with Cairo. Monitoring country activities.

    Science.gov (United States)

    Danguilan, M; Wainer, J; Widyantoro, N; Capoor, I; Huq, N; Ashino, Y; Sadasivam, B; Le Thi Nham Tuyet

    1995-04-01

    In the aftermath of the 1994 UN Conference on Population and Development (ICPD) in Cairo, countries are proceeding with their implementation of the plan of action adopted at the conference. A brief description is given of some actions taken by specific countries toward plan implementation. In the Philippines meetings were held immediately after the conference in October on the implications for the Management, Family Planning, and Nongovernmental Organizations programs. The issues of concern were identified as the need for regular consultative meetings among relevant agencies, consultations with women's groups, and a responsive adolescents program. In Australia the program thrust was to focus on the implications for immigration. Monitoring of the plans of action will be undertaken by nongovernmental organizations (NGOs). In Malaysia committees are preparing a program of action suitable for implementation in Malaysia. A regional women's NGO organized a forum on the implications of ICPD for women's reproductive health, women's rights, and empowerment in Malaysia. In Vietnam, press conferences are used to communicate conference results. An NGO translated relevant ICPD materials into Vietnamese. In Indonesia, several ministries convened meetings among donors, NGOs, women's groups, and experts. In India, the government held a national conference. One view was that population issues should be discussed in the context of gender equality and empowerment of women. Another issue was the importance of placing reproductive health in the larger context of health and primary health services. Health personnel at all levels were considered in need of sensitization on gender issues. Problems such as anemia have not been successfully addressed in existing programs. The government agreed to remove in phases target driven programs and the sterilization emphasis. In Bangladesh, a national committee was formed, and NGOs are actively distributing information. In Japan, the Family Planning

  9. Clinicopathological Characteristics of Colon Cancer Diagnosed at Primary Health Care Institutions

    OpenAIRE

    Park, Sang Hyun; Song, Chi Wook; Kim, Yun Bae; Kim, Young Sun; Chun, Hwang Rae; Lee, Jung Hyun; Seol, Won Jong; Yoon, Hyung Sun; Lee, Myung Kwon; Lee, Jong Hyup; Bhang, Choon Sang; Park, Jae Hyung; Park, Ji Young; Do, Byung Hun; Park, Young Dae

    2014-01-01

    Background/Aims The purpose of this study was to evaluate the clinicopathologic characteristics of colon cancers detected at the SOK Sokpeynhan Internal Medical Network, a nationwide system of primary health care institutions. Methods We analyzed 579 colon cancer patients diagnosed using colonoscopy at the SOK network from January 2011 through December 2012. Cancers from the rectum to the splenic flexure were classified as left colon cancer. Patients over 65 were classified as senior. Results...

  10. 75 FR 26267 - National Cancer Institute; Notice of Meeting

    Science.gov (United States)

    2010-05-11

    ... personal privacy. Name of Committee: National Cancer Advisory Board Ad hoc Subcommittee on Experimental Therapeutics. Open: June 21, 2010, 6:30 p.m. to 8 p.m. Agenda: Discussion on Experimental Therapeutics. Place... Prevention Research; 93.394, Cancer Detection and Diagnosis Research; 93.395, Cancer Treatment Research;...

  11. Sound preferences of the dense urban environment: Soundscape of Cairo

    Directory of Open Access Journals (Sweden)

    Mostafa Refat Ismail

    2014-03-01

    Analyzing the relative annoyance increase (RAI of the close-ended part, overall positive RAI values for all sound categories reveal how sensitive to noise Cairo residents are. Results further showed that at an RAI value of approximately 27%, sound category perception transforms from positive to negative.

  12. Assembling a Revolution: Graffiti, Cairo and the Arab Spring

    Directory of Open Access Journals (Sweden)

    John Lennon

    2014-03-01

    Full Text Available This essay examines the ways revolutionary desire was articulated and interpreted through graffiti in Cairo, Egypt during the Arab Spring and its immediate aftermath. For writers in Cairo, graffiti was one of many in a constellation of resistances that undermined everyday life in Hosni Mubarak’s Egypt and the SCAF-controlled interim government. Ordinary surfaces of the city were illegally marked, displaying revolutionary potentiality by allowing the seemingly powerless rhetorical openings of engagement. Far from being a monolithic discourse, graffiti created geographies of material protest that were locally enacted but globally contextualized. Political graffiti, like the overall protests of the Arab Spring, emerged in large numbers at particular moments, but its numerous roots spread distinctly into the past. First contextualizing Cairo graffiti as a tool for revolutionary protest, the article then examines specific writers (Mahmoud Graffiti, Ganzeer, particular ‘battleground' spaces (Tahrir Square, Mohamed Mahmoud Street, different graffiti mutations (tags, pieces, murals and contrary aesthetic manipulations of the form (‘No Walls’ campaign, graffiti advertisements by multinational corporations in order to assemble a graffiti scene in Cairo as it follows the ebbs and flows of revolutionary desire.

  13. Cancer in human immunodeficiency virus-infected children : A case series from the Children's Cancer Group and the National Cancer Institute

    NARCIS (Netherlands)

    Granovsky, MO; Mueller, BU; Nicholson, HS; Rosenberg, PS; Rabkin, CS

    1998-01-01

    Purpose: To describe the spectrum of malignancies in human immunodeficiency virus (HIV)-infected children and the clinical outcome of patients with these tumors. Methods: We retrospectively surveyed the Children's Cancer Group (CCG) and the National Cancer institute (NCI) for cases of cancer that oc

  14. Adherence to the World Cancer Research Fund/American Institute for Cancer Research lifestyle recommendations in colorectal cancer survivors : Results of the PROFILES registry

    NARCIS (Netherlands)

    Winkels, Renate M; van Lee, Linde; Beijer, Sandra; Bours, Martijn J; van Duijnhoven, Fränzel J B; Geelen, Anouk; Hoedjes, Meeke; Mols, F.; de Vries, Jeanne; Weijenberg, Matty P; Kampman, Ellen

    2016-01-01

    We examined adherence to the eight The World Cancer Research Foundation/American Institute for Cancer Research (WCRF/AICR) recommendations on diet, physical activity, and body weight among colorectal cancer survivors, and whether adherence was associated with intention to eat healthy and with the ne

  15. 77 FR 51032 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2012-08-23

    ... patentable material, and personal information concerning individuals associated with the grant applications... & Conference Center 5701 Marinelli Road Bethesda, MD 20852. Contact Person: Jeannette F. Korczak, Ph.D... Nos. 93.392, Cancer Construction; 93.393, Cancer Cause and Prevention Research; 93.394,...

  16. 77 FR 29674 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2012-05-18

    ... property such as patentable material, and personal information concerning individuals associated with the... evaluate grant applications. Place: Bethesda North Marriott Hotel Conference & Center, 5701 Marinelli Road.... (Catalogue of Federal Domestic Assistance Program Nos. 93.392, Cancer Construction; 93.393, Cancer Cause...

  17. 77 FR 56215 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2012-09-12

    ... patentable material, and personal information concerning individuals associated with the grant applications.... Place: Bethesda North Marriott Hotel & Conference Center, 5701 Marinelli Road, Bethesda, MD 20852... Federal Domestic Assistance Program Nos. 93.392, Cancer Construction; 93.393, Cancer Cause and...

  18. 76 FR 64090 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2011-10-17

    ... commercial property such as patentable material, and personal information concerning individuals associated... Conference & Center Hotel, 5701 Marinelli Road, Bethesda, MD 20852. Contact Person: Clifford W Schweinfest... Nos. 93.392, Cancer Construction; 93.393, Cancer Cause and Prevention Research; 93.394,...

  19. 75 FR 66770 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-10-29

    ... patentable material, and personal information concerning individuals associated with the grant applications... applications. Place: Bethesda North Marriott Hotel & Conference Center, 5701 Marinelli Road, Bethesda, MD 20852... Program Nos. 93.392, Cancer Construction; 93.393, Cancer Cause and Prevention Research; 93.394,...

  20. 78 FR 66373 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-11-05

    ... new diagnostics for cancer. Place: NCI Shady Grove, 9609 Medical Center Drive, Room 3W030, Rockville... diagnostics. The outcome of the evaluation will be information for consideration by an internal NCI committee... development of the potential diagnostics to improve the treatment of cancer. The research proposals and...

  1. Trends in Research on Energy Balance Supported by the National Cancer Institute

    OpenAIRE

    Ballard-Barbash, Rachel; Siddiqi, Sameer M.; Berrigan, David A.; Ross, Sharon A.; Nebeling, Linda C.; Dowling, Emily C.

    2013-01-01

    Over the past decade, the body of research linking energy balance to the incidence, development, progression and treatment of cancer has grown substantially. No prior NIH portfolio analyses have focused on energy balance within one institute. This portfolio analysis describes the growth of National Cancer Institute (NCI) grant research on energy balance–related conditions and behaviors from 2004 to 2010 following the release of an NCI research priority statement in 2003 on energy balance and ...

  2. 78 FR 25281 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2013-04-30

    ... patentable material, and personal information concerning individuals associated with the grant applications... grant applications. Place: Bethesda North Marriott Hotel & Conference Center, 5701 Marinelli Road...@mail.nih.gov . (Catalogue of Federal Domestic Assistance Program Nos. 93.392, Cancer Construction;...

  3. 77 FR 12600 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2012-03-01

    ...; Quantitative Imaging for Evaluation of Responses to Cancer Therapies. Date: March 8, 2012. Time: 1 p.m. to 5 p... Emphasis Panel Cancer Imaging. Date: March 6, 2012. Time: 11 a.m. to 3 p.m. Agenda: To review and evaluate... Phase IIB Bridge Awards. Date: March 20, 2012. Time: 11 a.m. to 4 p.m. Agenda: To review and...

  4. The National Cancer Institute's Physical Sciences - Oncology Network

    Science.gov (United States)

    Espey, Michael Graham

    In 2009, the NCI launched the Physical Sciences - Oncology Centers (PS-OC) initiative with 12 Centers (U54) funded through 2014. The current phase of the Program includes U54 funded Centers with the added feature of soliciting new Physical Science - Oncology Projects (PS-OP) U01 grant applications through 2017; see NCI PAR-15-021. The PS-OPs, individually and along with other PS-OPs and the Physical Sciences-Oncology Centers (PS-OCs), comprise the Physical Sciences-Oncology Network (PS-ON). The foundation of the Physical Sciences-Oncology initiative is a high-risk, high-reward program that promotes a `physical sciences perspective' of cancer and fosters the convergence of physical science and cancer research by forming transdisciplinary teams of physical scientists (e.g., physicists, mathematicians, chemists, engineers, computer scientists) and cancer researchers (e.g., cancer biologists, oncologists, pathologists) who work closely together to advance our understanding of cancer. The collaborative PS-ON structure catalyzes transformative science through increased exchange of people, ideas, and approaches. PS-ON resources are leveraged to fund Trans-Network pilot projects to enable synergy and cross-testing of experimental and/or theoretical concepts. This session will include a brief PS-ON overview followed by a strategic discussion with the APS community to exchange perspectives on the progression of trans-disciplinary physical sciences in cancer research.

  5. Validation of Cancer Institute Quality of Life Questionnaire Version II for cancer patients in India

    Directory of Open Access Journals (Sweden)

    E Vidhubala

    2011-01-01

    Full Text Available Background: The Quality of Life (QOL questionnaire version I consisted of 38 items that were validated using 392 patients. The experiences gained through the interaction with the patients during the administration of the questionnaire provided a lot of inputs for the improvization of the tool. Aim: The current study is aimed at certain modifications of the QOL questionnaire version I and standardization of the same. Materials and Methods: The modifications of version I QOL scale included the change of verbatim, splitting, deleting, and adding of new items. Finally, version II included 42 items. It was administered to 183 cancer patients irrespective of their demographic details for further standardization. Statistics: The principal component method with varimax rotation was used. Spearman′s product moment correlation and Cronbach′s alpha coefficient were used for reliability analysis. Results: The data were subjected to factor analysis to explore the factors. Eleven factors emerged with the eigenvalue ranging from 8.03 to 1.10 and accounted for 66.7% variance. The first factor contributed maximally, 19.5%, and the remaining 10 factors contributed a total of 46.2% variance on QOL. They are general well-being, physical well-being, psychological well-being, familial relationship, sexual and personal ability, cognitive well-being, optimism and belief, economical well-being, information support, patient-physician relationship, and body image. The Cronbach alpha of 0.90 and split-half reliability of 0.80 indicated a high reliability of the tool. Conclusion: The factor structure showed that QOL is a multidimensional concept having different aspects. The Cancer Institute QOL Questionnaire version II for cancer patients is found to be a valid and reliable tool and feasible to administer at the clinical settings.

  6. Annual Patterns of Atmospheric Pollutions and Episodes over Cairo Egypt

    Directory of Open Access Journals (Sweden)

    Y. Aboel Fetouh

    2013-01-01

    Full Text Available The Nile Delta major cities, particularly Cairo, experienced stagnant air pollution episodes, known as Black Cloud, every year over the past decade during autumn. Low-elevated thermal inversion layers play a crucial role in intensifying pollution impacts. Carbon monoxide, ozone, atmospheric temperature, water vapor, and methane measurements from the tropospheric emission spectrometer (TES on board the Aura have been used to assess the dominant component below the inversion layer. In this study, time series analysis, autocorrelations, and cross correlations are performed to gain a better understanding of the connections between those parameters and their local effect. Satellite-based data were obtained for the years 2005–2010. The parameters mentioned were investigated throughout the whole year in order to study the possible episodes that take place in addition to their change from year to year. Ozone and carbon monoxide were the two major indicators to the most basic episodes that occur over Cairo and the Delta region.

  7. Annual Patterns of Atmospheric Pollutions and Episodes over Cairo Egypt

    OpenAIRE

    Y. Aboel Fetouh; H. El Askary; El Raey, M.; Allali, M; Sprigg, W. A.; M. Kafatos

    2013-01-01

    The Nile Delta major cities, particularly Cairo, experienced stagnant air pollution episodes, known as Black Cloud, every year over the past decade during autumn. Low-elevated thermal inversion layers play a crucial role in intensifying pollution impacts. Carbon monoxide, ozone, atmospheric temperature, water vapor, and methane measurements from the tropospheric emission spectrometer (TES) on board the Aura have been used to assess the dominant component below the inversion layer. In this stu...

  8. Mellem Kunst og Aktivisme - Street Art i Cairo

    OpenAIRE

    Vasii, Sarah Borger

    2010-01-01

    The subject matter of the project is the growing Street Art scene in Egypt, and is predominantly based on three interviews conducted with two active Street Artists and the main Street Art-blogger in Cairo. Analytically I differentiate between an artistic and an activist perspective, drawing respectively on the theoretical and analytical concepts of Pierre Bourdieu and the geographical concept of scale as it is defined by Sally A. Marston and Neil Smith. The first part of the analysis looks...

  9. Analysis of pollutants in human scalp hair in Cairo

    International Nuclear Information System (INIS)

    Scalp hair, urine and blood samples from volunteers selected from different areas surrounding Cairo were collected for study by neutron activation analysis (NAA) and conventional methods. The results for 14 elements in hair show some variation between the different regions. Qualitatively there is a slight difference of abundance of the investigated elements. Broadly speaking the presence of major elements is dominant. No relationship was observed between the elemental composition of hair and urine. (author)

  10. Reverse Gear: Cairo's Dependence on a Disappearing Paradigm

    Institute of Scientific and Technical Information of China (English)

    Malcolm Potts; Martha Campbell

    2005-01-01

    In the 1960s and 1970 s, attention was focused on rapid population growth and large scale family planning programs were launched in many developing countries.However, the paradigm for understanding fertility decline assumed that exogenous socioeconomic changes were necessary to reduce family size. By the mid-1990s, the standard model of the demographic transition had been all but discarded, partly there were numerous country experiences inconsistent with the model. The 1994 International Conference on Population and Development (ICPD) emphasized women's broader needs, which were important but were promoted by reducing attention to population and the need for family planning. The timing of this shift was peculiar, because the Cairo proponents were depending on an already discredited model of reproductive behavior. The policy shift at Cairo undermined the political coalition that had supported international family planning since the 1960s. As a result of declining financial support, the health of women has deteriorated seriously in the past decade. Meantime,the countries that have been successful in lifting unprecedented numbers of people out of abject poverty were acting independently of the Cairo consensus.

  11. Challenges in DCIS Risk Communication and Decision-Making: Report from an American Cancer Society and National Cancer Institute Workshop

    OpenAIRE

    Partridge, Ann H.; Elmore, Joann G.; Saslow, Debbie; McCaskill-Stevens, Worta; Schnitt, Stuart J.

    2012-01-01

    In September 2010, the American Cancer Society and National Cancer Institute convened a conference to review current issues in DCIS risk communication and decision-making and to identify directions for future research. Specific topics included patient and healthcare provider knowledge and attitudes about DCIS and its treatment, how to explain DCIS to patients given the heterogeneity of the disease, consideration of nomenclature changes, and the utility of decision tools/aids. This report desc...

  12. Lower Breast Cancer Risk among Women following the World Cancer Research Fund and American Institute for Cancer Research Lifestyle Recommendations: EpiGEICAM Case-Control Study

    OpenAIRE

    Adela Castelló; Miguel Martín; Amparo Ruiz; Casas, Ana M.; Baena-Cañada, Jose M; Virginia Lope; Silvia Antolín; Pedro Sánchez; Manuel Ramos; Antonio Antón; Montserrat Muñoz; Begoña Bermejo; Ana De Juan-Ferré; Carlos Jara; José I Chacón

    2015-01-01

    Background According to the “World Cancer Research Fund” and the “American Institute of Cancer Research” (WCRF/AICR) one in four cancer cases could be prevented through a healthy diet, weight control and physical activity. Objective To explore the association between the WCRF/AICR recommendations and risk of breast cancer. Methods During the period 2006 to 2011 we recruited 973 incident cases of breast cancer and 973 controls from 17 Spanish Regions. We constructed a score based on 9 of the W...

  13. Intraoperative Radiotherapy for Parotid Cancer: A Single-Institution Experience

    International Nuclear Information System (INIS)

    Purpose: Our practice policy has been to provide intraoperative radiotherapy (IORT) at resection to patients with head-and-neck malignancies considered to be at high risk of recurrence. The purpose of the present study was to review our experience with the use of IORT for primary or recurrent cancer of the parotid gland. Methods and Materials: Between 1982 and 2007, 96 patients were treated with gross total resection and IORT for primary or recurrent cancer of the parotid gland. The median age was 62.9 years (range, 14.3–88.1). Of the 96 patients, 33 had previously undergone external beam radiotherapy as a component of definitive therapy. Also, 34 patients had positive margins after surgery, and 40 had perineural invasion. IORT was administered as a single fraction of 15 or 20 Gy with 4–6-MeV electrons. The median follow-up period was 5.6 years. Results: Only 1 patient experienced local recurrence, 19 developed regional recurrence, and 12 distant recurrence. The recurrence-free survival rate at 1, 3, and 5 years was 82.0%, 68.5%, and 65.2%, respectively. The 1-, 3-, and 5-year overall survival rate after surgery and IORT was 88.4%, 66.1%, and 56.2%, respectively. No perioperative fatalities occurred. Complications developed in 26 patients and included vascular complications in 7, trismus in 6, fistulas in 4, radiation osteonecrosis in 4, flap necrosis in 2, wound dehiscence in 2, and neuropathy in 1. Of these 26 patients, 12 had recurrent disease, and 8 had undergone external beam radiotherapy before IORT. Conclusions: IORT results in effective local disease control at acceptable levels of toxicity and should be considered for patients with primary or recurrent cancer of the parotid gland.

  14. Sunitinib treatment in patients with advanced renal cell cancer: the Brazilian National Cancer Institute (INCA) experience

    Science.gov (United States)

    Coelho, Rafael Corrêa; Reinert, Tomás; Campos, Franz; Peixoto, Fábio Affonso; de Andrade, Carlos Augusto; Castro, Thalita; Herchenhorn, Daniel

    2016-01-01

    ABSTRACT Purpose: The aim of this study was to assess the impact of sunitinib treatment in a non-screened group of patients with metastatic renal cell cancer (mRCC) treated by the Brazilian Unified Health System (SUS) at a single reference institution. Material and Methods: Retrospective cohort study, which evaluated patients with mRCC who received sunitinib between May 2010 and December 2013. Results: Fifty-eight patients were eligible. Most patients were male 41 (71%), with a median age of 58 years. Nephrectomy was performed in 41 (71%) patients with a median interval of 16 months between the surgery and initiation of sunitinib. The most prevalent histological subtype was clear cell carcinoma, present in 52 (91.2%) patients. In 50 patients (86%), sunitinib was the first line of systemic treatment. The main adverse effects were fatigue (57%), hypothyroidism (43%), mucositis (33%) and diarrhea (29%). Grade 3 and 4 adverse effects were infrequent: fatigue (12%), hypertension (12%), thrombocytopenia (7%), neutropenia (5%) and hand-foot syndrome (5%). Forty percent of patients achieved a partial response and 35% stable disease, with a disease control rate of 75%. Median progression free survival was 7.6 months and median overall survival was 14.1 months. Conclusion: Sunitinib treatment was active in the majority of patients, especially those with low and intermediate risk by MSKCC score, with manageable toxicity. Survival rates were inferior in this non-screened population with mRCC treated in the SUS. PMID:27564279

  15. Iodine-125 seed brachytherapy for early stage prostate cancer: a single-institution review

    OpenAIRE

    Zuber, Simon; Weiß, Susan; Baaske, Dieter; Schöpe, Michael; Stevens, Simon; Bodis, Stephan; Zwahlen, Daniel R.

    2015-01-01

    Purpose We are reporting the five-year biochemical control, toxicity profile and dosimetric parameters using iodine-125 low dose rate brachytherapy (BT) as monotherapy for early stage prostate cancer at a single institution. Material and methods Between April 2006 and December 2010, 169 men with early stage prostate cancer were treated with BT. Biochemical failure was defined using the Phoenix definition (nadir + 2 ng/mL). Treatment-related morbidities, including urinary, rectal and sexual fu...

  16. Iodine-125 seed brachytherapy for early stage prostate cancer: a single-institution review

    OpenAIRE

    Zuber, Simon; Weiß, Susan; Baaske, Dieter; Schöpe, Michael; Stevens, Simon; Bodis, Stephan; Zwahlen, Daniel R.

    2015-01-01

    PURPOSE: We are reporting the five-year biochemical control, toxicity profile and dosimetric parameters using iodine-125 low dose rate brachytherapy (BT) as monotherapy for early stage prostate cancer at a single institution. MATERIAL AND METHODS: Between April 2006 and December 2010, 169 men with early stage prostate cancer were treated with BT. Biochemical failure was defined using the Phoenix definition (nadir + 2 ng/mL). Treatment-related morbidities, including urinary, rectal and sexu...

  17. Multi-Institutional Analysis of Early Glottic Cancer from 2000 to 2005

    OpenAIRE

    Hirasawa Naoki; Itoh Yoshiyuki; Naganawa Shinji; Ishihara Shunichi; Suzuki Kazunori; Koyama Kazuyuki; Murao Takayuki; Asano Akiko; Nomoto Yoshihito; Horikawa Yoshimi; Sasaoka Masahiro; Obata Yasunori

    2012-01-01

    Abstract Background The purpose of this study is to analyze the outcome of patients with early glottic cancer (GC) treated with radiotherapy (RT) with or without chemotherapy at 10 institutions in the Tokai District, Japan. Methods Ten institutions combined data from 279 patients with T1-T2 GC treated with RT with or without chemotherapy between 2000 and 2005. The overall survival rate, disease-specific survival rate, and local control rate were evaluated in 270 patients, except for incomplet...

  18. Management of Ontario children with acute lymphoblastic leukemia by the Dana-Farber Cancer Institute protocols.

    OpenAIRE

    Desai, S J; Barr, R D; Andrew, M.; deVeber, L L; Pai, M K

    1989-01-01

    There is ample evidence of the value of intensive therapeutic strategies in the management of acute lymphoblastic leukemia (ALL), the commonest form of malignant disease in children. Such a program, devised at the Dana-Farber Cancer Institute (DFCI), Boston, and incorporating high-dose L-asparaginase, was adopted in 1984 by the Children's Hospital at Chedoke-McMaster, Hamilton, Ont., and the Children's Hospital of Western Ontario, London. We describe the experience of these institutions in th...

  19. The Childhood Cancer Survivor Study: a National Cancer Institute-supported resource for outcome and intervention research.

    Science.gov (United States)

    Robison, Leslie L; Armstrong, Gregory T; Boice, John D; Chow, Eric J; Davies, Stella M; Donaldson, Sarah S; Green, Daniel M; Hammond, Sue; Meadows, Anna T; Mertens, Ann C; Mulvihill, John J; Nathan, Paul C; Neglia, Joseph P; Packer, Roger J; Rajaraman, Preetha; Sklar, Charles A; Stovall, Marilyn; Strong, Louise C; Yasui, Yutaka; Zeltzer, Lonnie K

    2009-05-10

    Survival for childhood cancer has increased dramatically over the last 40 years with 5-year survival rates now approaching 80%. For many diagnostic groups, rapid increases in survival began in the 1970s with the broader introduction of multimodality approaches, often including combination chemotherapy with or without radiation therapy. With this increase in rates of survivorship has come the recognition that survivors are at risk for adverse health and quality-of-life outcomes, with risk being influenced by host-, disease-, and treatment-related factors. In 1994, the US National Cancer Institute funded the Childhood Cancer Survivor Study, a multi-institutional research initiative designed to establish a large and extensively characterized cohort of more than 14,000 5-year survivors of childhood and adolescent cancer diagnosed between 1970 and 1986. This ongoing study, which reflects the single most comprehensive body of information ever assembled on childhood and adolescent cancer survivors, provides a dynamic framework and resource to investigate current and future questions about childhood cancer survivors. PMID:19364948

  20. Outcome and treatment strategy in female lung cancer: a single institution experience

    International Nuclear Information System (INIS)

    Purpose: To assess the survival rate of female lung cancer treated at the Institute of Oncology of the Vilnius University, Lithuania during the period between 1996-2005. Materials and Methods: During the period between 1996-2005, 471 women diagnosed with lung cancer were treated at the Department of Thoracic Surgery and Oncology of the Institute of Oncology, Vilnius University. Data on morphology, stage and treatment was collected from the medical records. All lung cancer cases by histology were classified in two groups: non-small cell lung cancer (includes squamous cell carcinoma, large cell carcinoma, adenocarcinoma and other less common types) and small cell lung cancer. The vital status of the study group was assessed as of December 31, 2007, by passive follow-up, using data from the population registry. It was found that 411 (87.3%) of the patients had died. Survival was estimated according to the Kaplan-Meier method. Results: The median survival of female lung cancer diagnosed during 1996-2005 in Lithuania show to be 8.7 months (8.4 (95% CI 7.2-10.8) months with non-small cell lung cancer and 9.3 (95% CI 6.3-13.0) months with small-cell lung cancer). Survival was more than 20 months in resectable non-small cell lung cancer (stages I, II, IIIA). Non-small cell lung cancer survival in advanced stages was less than 7 months. Small-cell lung cancer patients median survival at limited and extended stages of the disease were 9.5 (95% CI 2.9-18.4) compared to 9.2 (95% CI 6.2-13.7) months. Non-small cell lung cancer patients most frequently were treated by surgery (27.0%), surgery and chemotherapy or radiotherapy (19.6%). Small cell lung cancer patient treatment included chemo and radiotherapy (27.0%), chemotherapy (19.0%), radiotherapy (17.5%), surgery (27.9%). Conclusions: The single center study of female lung cancer diagnosed during 1996-2005 in Lithuania show a significantly better chance of survival in resectable non-small cell lung cancer. Advanced stages of

  1. Epidemiology of epithelial ovarian cancer, a single institution-based study in India

    Directory of Open Access Journals (Sweden)

    Surendra Kumar Saini

    2016-01-01

    Full Text Available Background: Ovarian cancer is the leading cause of mortality among all cancers of female genital tract in countries where effective cervical cancer screening program exists. As the world's population ages, remarkable increase in the total number of ovarian cancer cases are expected. This is preliminary epidemiological study to decide priorities in ovarian cancer research. Materials and Methods: A retrospective study was conducted with primary epithelial ovarian cancer cases registered in J. K. Cancer Institute, Kanpur (Uttar Pradesh, from 2007 to 2009. Patients' age at diagnosis, clinical feature, parity of patients, tumor histological type, Federation of Gynecology and Obstetrics stage, chemotherapy regimens, and overall survival data were collected and analyzed. Results: One hundred and sixty-three cases of primary ovarian epithelial cancer were analyzed. Patients' mean age at diagnosis was 55.98 ± 9.24 (median = 55. Serous adenocarcinoma (49.69% was the most prevalent type of histopathology followed by endometroid (19.1%, mucinous (10.42% and clear cell (4.29%. Combination of taxane and platin was most commonly used first line regimen in newly diagnosed as well as in relapsed patients post 1 year. Survival was not significantly different in various histopathology (log-rank P = 0.7406, but advancing stage demonstrated gradually poor survival (log-rank P < 0.05 when compared with early stage disease. Conclusion: Research efforts should be in the direction to find early diagnostic and effective screening tools as well as better therapeutic approaches for advanced epithelial ovarian cancer.

  2. Origin of black carbon concentration peaks in Cairo (Egypt)

    Energy Technology Data Exchange (ETDEWEB)

    Mahmoud, K.F.; Wahab, M.M.A. [Cairo Univ, Fac Sci, Astron and Meteorol Dept, Giza (Egypt); Alfaro, S.C. [Univ Paris 12, LISA, F-94010 Creteil, (France); Alfaro, S.C. [Univ Paris 07, CNRS, F-94010 Creteil (France); Favez, O.; Sciare, J. [CEA Saclay, DSM, LSCE IPSL, Lab mixte CEA-CNRS-UVSQ, F-91191 Gif Sur Yvette (France)

    2008-07-01

    The concentration in black carbon (BC) has been monitored in the mega-city of Cairo (Egypt) during the autumn 2004 and spring 2005 intensive observation periods of the Cairo Aerosol Characterization Experiment (CACHE). As expected for a species released by human activities, hourly mean of this concentration is found to be large at all times. It is also significantly larger in autumn than in spring (9.9 {+-} 6.6 and 6.9 {+-} 4.8 {mu}gC/m{sup 3}, respectively) and quite variable at shorter (diurnal) time scales. Indeed, sharp concentration peaks larger than 25 {mu}gC/m{sup 3} are frequently detected during both observation periods. In order to apportion the roles played by emission intensity and meteorological conditions in the development of these peaks, a simple model is developed that allows derivation of the hourly mean BC emissions by the part of town located upwind of the measurement site. The analysis of the time dependence of these emissions indicates that traffic is by far the major source of BC in Cairo during daytime and this even in autumn when biomass burning takes place in the Nile delta. It is only between 03:00 and 05:00 in the night, at a time when traffic emissions are quite reduced, that the influence of this particular source on BC concentration can become significant. This study also indicates that BC emissions by motorized traffic remain important from the morning rush hour until late in the night. During the day, and particularly in spring, the dilution effect resulting from the development of the planetary boundary layer prevents BC concentrations from becoming very large. This is no longer the case just before sunrise and after sunset, when the combination of dense traffic and low boundary layer is responsible for the observed sharp increase in BC concentration. (authors)

  3. Residual Stress Studies Using the Cairo Fourier Diffractometer Facility

    International Nuclear Information System (INIS)

    The present paper deals with residual stress studies using the Cairo Fourier diffractometer facility CFDF. The CFDF is a reverse - time of -flight (RTOF) diffractometer; applies a Fourier chopper. The measurements were performed for copper samples in order to study the residual stress after welding. The maximum modulation of the Fourier chopper during the measurements was 136 khz; leading to a time resolution half-width of about 7 μ s. It has been found from the present measurements that, the resulting diffraction spectra could be successfully used for studying the residual stress; in the wavelength range between 0.7-2.9 A degree at ∼ 0.45 % relative resolution

  4. Getting into hot water Problematizing hot water service demand: The case of Old Cairo

    Science.gov (United States)

    Culhane, Thomas Henry

    This dissertation analyzes hot water demand and service infrastructure in two neighboring but culturally distinct communities of the urban poor in the inner-city area of central Cairo. The communities are the Historic Islamic Cairo neighborhood of Darb Al Ahmar at the foot of Al-Azhar park, and the Zurayib neighborhood of Manshiyat Nasser where the Coptic Zabaleen Recyclers live. The study focuses on the demand side of the hot water issue and involves consideration of built-environment infrastructures providing piped water, electricity, bottled gas, sewage, and the support structures (wiring and plumbing) for consumer durables (appliances such as hot water heaters, stoves, refrigerators, air conditioners) as well as water pumps and water storage tanks. The study asks the questions "How do poor communities in Cairo value hot water" and "How do cost, infrastructure and cultural preferences affect which attributes of hot water service are most highly preferred?". To answer these questions household surveys based primarily on the World Bank LSMS modules were administered by professional survey teams from Darb Al Ahmar's Aga Khan Trust for Culture and the Zabaleen's local NGO "Spirit of Youth" in their adjacent conununities in and surrounding historic Cairo. In total 463 valid surveys were collected, (231 from Darb Al Ahmar, 232 from the Zabaleen). The surveys included a contingent valuation question to explore Willingness to Pay for improved hot water service; the surveys queried household assets as proxies for income. The dissertation's findings reveal that one quarter of the residents of Darb Al Ahmar and two-thirds of the residents of Manshiyet Nasser's Zabaleen lack conventional water heating service. Instead they employ various types of stoves and self-built contraptions to heat water, usually incurring considerable risk and opportunity costs. However the thesis explores the notion that this is rational "satisficing" behavior; despite the shortcomings of such self

  5. A multi-institute case-control study on the risk factors of developing pancreatic cancer.

    Science.gov (United States)

    Mizuno, S; Watanabe, S; Nakamura, K; Omata, M; Oguchi, H; Ohashi, K; Ohyanagi, H; Fujiki, T; Motojima, K

    1992-08-01

    A multi-institute, hospital-based, case-control study on pancreatic cancer was carried out to examine its association with preceding diseases, cigarette smoking, alcohol drinking and dietary factors. Analyses were based on 124 newly diagnosed exocrine pancreatic cancer cases and sex-, age- and institute-matched hospital controls in seven hospitals in Japan. Cigarette smoking showed a positive association with the risk of developing pancreatic cancer. Especially among smokers, a risk enhancing effect of involuntary/passive smoking prior to twenty years of age was observed (P tea or alcohol consumption. Among dietary factors, favoring food of a salty taste and drinking green tea five cups per day or more were positively associated with the risk. Drinking milk and eating fish everyday were inversely associated with the risk. PMID:1434027

  6. Profile of patients with lung cancer assisted at the National Cancer Institute, according to their smoking status, from 2000 to 2007

    OpenAIRE

    Mirian Carvalho de Souza; Ana Glória Godoi Vasconcelos; Marise Souto Rebelo; Paulo Antonio de Paiva Rebelo; Oswaldo Gonçalves Cruz

    2014-01-01

    INTRODUCTION: Tobacco use is directly related to the future incidence of lung cancer. In Brazil, a growing tendency in age-adjusted lung cancer mortality rates was observed in recent years. OBJECTIVE: To describe the profile of patients with lung cancer diagnosed and treated at the National Cancer Institute (INCA) in Rio de Janeiro, Brazil, between 2000 and 2007 according to their smoking status. METHODS: An observational study was conducted using INCA's database of cancer cases. To ...

  7. Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3

    Directory of Open Access Journals (Sweden)

    Lund Eiliv

    2009-07-01

    Full Text Available Abstract Background Gonadotropin releasing hormone (GNRH1 triggers the release of follicle stimulating hormone and luteinizing hormone from the pituitary. Genetic variants in the gene encoding GNRH1 or its receptor may influence breast cancer risk by modulating production of ovarian steroid hormones. We studied the association between breast cancer risk and polymorphisms in genes that code for GNRH1 and its receptor (GNRHR in the large National Cancer Institute Breast and Prostate Cancer Cohort Consortium (NCI-BPC3. Methods We sequenced exons of GNRH1 and GNRHR in 95 invasive breast cancer cases. Resulting single nucleotide polymorphisms (SNPs were genotyped and used to identify haplotype-tagging SNPs (htSNPS in a panel of 349 healthy women. The htSNPs were genotyped in 5,603 invasive breast cancer cases and 7,480 controls from the Cancer Prevention Study-II (CPS-II, European Prospective Investigation on Cancer and Nutrition (EPIC, Multiethnic Cohort (MEC, Nurses' Health Study (NHS, and Women's Health Study (WHS. Circulating levels of sex steroids (androstenedione, estradiol, estrone and testosterone were also measured in 4713 study subjects. Results Breast cancer risk was not associated with any polymorphism or haplotype in the GNRH1 and GNRHR genes, nor were there any statistically significant interactions with known breast cancer risk factors. Polymorphisms in these two genes were not strongly associated with circulating hormone levels. Conclusion Common variants of the GNRH1 and GNRHR genes are not associated with risk of invasive breast cancer in Caucasians.

  8. Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)

    International Nuclear Information System (INIS)

    Gonadotropin releasing hormone (GNRH1) triggers the release of follicle stimulating hormone and luteinizing hormone from the pituitary. Genetic variants in the gene encoding GNRH1 or its receptor may influence breast cancer risk by modulating production of ovarian steroid hormones. We studied the association between breast cancer risk and polymorphisms in genes that code for GNRH1 and its receptor (GNRHR) in the large National Cancer Institute Breast and Prostate Cancer Cohort Consortium (NCI-BPC3). We sequenced exons of GNRH1 and GNRHR in 95 invasive breast cancer cases. Resulting single nucleotide polymorphisms (SNPs) were genotyped and used to identify haplotype-tagging SNPs (htSNPS) in a panel of 349 healthy women. The htSNPs were genotyped in 5,603 invasive breast cancer cases and 7,480 controls from the Cancer Prevention Study-II (CPS-II), European Prospective Investigation on Cancer and Nutrition (EPIC), Multiethnic Cohort (MEC), Nurses' Health Study (NHS), and Women's Health Study (WHS). Circulating levels of sex steroids (androstenedione, estradiol, estrone and testosterone) were also measured in 4713 study subjects. Breast cancer risk was not associated with any polymorphism or haplotype in the GNRH1 and GNRHR genes, nor were there any statistically significant interactions with known breast cancer risk factors. Polymorphisms in these two genes were not strongly associated with circulating hormone levels. Common variants of the GNRH1 and GNRHR genes are not associated with risk of invasive breast cancer in Caucasians

  9. Report of the first meeting of the Project Advisory Committee (Technical) 21-24 March 1983, at NEMROCK, Cairo

    International Nuclear Information System (INIS)

    The Project Advisory Committee (Technical) (PACT) met on 21-24 March 1983, at NEMROCK, Cairo, Egypt, to discuss the joint IAEA/WHO project on Intracavitary Radiation Therapy for Cancer of the Uterus (Egypt/6/004). At this four day meeting the committee (1) identified a well-defined administrative framework in which earlier diagnosis of uterine cancer may be organized, on a limited but firm basis. (2) Agreed on the clinical and dosimetric principles to be followed in implementing the project. (3) Decided on the types and quantities of equipment which it will need in its first two years. (4) Developed the outline of the syllabus for the first training course, and fixed its date (three weeks from 83-10-29). (5) Reviewed the costs which will be incurred in carrying through the project and found them to be consistent with the funds available

  10. A comparative study of breast cancer mass screening using ultrasonography and mammography at a single institution

    International Nuclear Information System (INIS)

    In order to evaluate the effectiveness of ultrasonic screening for breast cancer (US group) in comparison with mammographic screening (MMG group), we analyzed 78,214 breast screening examinees presenting between 2007 and 2008 at our institution. The cancer detection rate in the US group was lower than that in the MMG group. However, the average age in the US group was significantly younger than that in the MMG group, and the rate of annual screening was significantly higher in the former than in the latter. In the US subgroup who underwent annual screening, the recall rate and the cancer detection rate were significantly lower, and the rate of detection of early breast cancers was significantly higher than that in the subgroup who underwent screening biennially or at longer intervals, and there was no significant inter-group difference in the cancer detection rate between women in their 40s and those aged 50 or above who underwent annual screening. The proportion of early breast cancers detected was almost the same in the both groups. In summary, US screening as well as MMG screening seems to be useful for detection of early breast cancer. Although a high recall rate for US screening has been reported previously, annual screening and sufficient quality control based on the guidelines proposed by the Japan Association of Breast and Thyroid Sonology (JABTS) are considered to reduce the recall rate. (author)

  11. Some radiation protection problems in a cancer hospital and associated research institute

    International Nuclear Information System (INIS)

    Experience gained at the Royal Marsden Hospital and Institute of Cancer Research has shown that with attention to the design of facilities and procedures and an active personnel monitoring policy, relatively large scale radiation commitments can proceed with individual whole body doses to staff being held well below 15 mSv/annum. In spite of detailed attention to control of radiation work, traumatic radiation incidents may still occur. (H.K.)

  12. Architectural and engineering design work for the Nevada Cancer Institute facility

    International Nuclear Information System (INIS)

    The purpose of this project was to complete the architectural and engineering design, program planning, and other preliminary work necessary to construct the new Nevada Cancer Institute facility. These goals were accomplished with the construction of a new building of approximately 119,000 gross square feet. The facility houses the diagnostic and radio therapeutic treatment laboratories, radiation oncology treatment facility, physician offices, and clinical research areas

  13. Treatment outcomes of female germ cell tumors: The Egyptian National Cancer Institute experience

    OpenAIRE

    Saber, Magdy M; Zeeneldin, Ahmed A.; Mosaad M. El Gammal; Salem E. Salem; Amira D. Darweesh; Alshaymaa A. Abdelaziz; Manar Monir

    2014-01-01

    Introduction: Female germ cell tumors (GCTS) are rare tumors that carry a good prognosis. Aim: To report the experience of the Egyptian National Cancer Institute (ENCI) in managing female GCTs. Methods: This retrospective study included 19 females with ovarian GCTs presenting to the ENCI between 2006 and 2010. Results: The median age was 23 years. Ovaries were the primary site in all patients. Dysgerminoma and teratoma were the predominant pathologies followed by mixed GCT in females...

  14. Long-term clinical outcomes of 420 consecutive prostate cancer patients in a single institute.

    Directory of Open Access Journals (Sweden)

    Edamura,Kohei

    2005-10-01

    Full Text Available

    This study was undertaken to reveal the trends of prostate cancer and the outcome of treatment modalities for each disease stage in patients in a single institute over a 10-year period. From January 1994 through December 2003, 420 consecutive patients with previously untreated and histologically confirmed prostate cancer were analyzed for annual distributions of disease stages and treatment modalities and for long-term clinical progression-free survival, prostate cancer-specific survival, and prostate-specific antigen (PSA failure-free survival rates for each stage and treatment modality. Annual trends showed that the number of patients, especially those with clinically localized cancer, increased dramatically. The 5-year disease-specific survival rates for patients with clinically localized disease were 100 percent for all treatment modalities, including hormonal therapy alone. Patients with PSA levels less than 10 ng/ml showed an 81 percent 5-year PSA failure-free survival rate with radical prostatectomy. Stage C patients treated by surgery or radiation-based therapy with concomitant hormonal therapy obtained 93 percent and 100 percent cause-specific survival rates, respectively, and those treated by hormonal therapy alone showed a 79 percent rate. The number of patients with localized prostate cancer was increasing in this decade. While long-term hormonal therapy alone was highly efficient in controlling localized prostate cancer, radical therapies in conjunction with neo-adjuvant hormonal therapy produced better survival rates in cases of locally advanced disease.

  15. Provenance studies of pottery fragments from medieval Cairo, Egypt

    International Nuclear Information System (INIS)

    In the analysis of archeological pottery fragments, instrumental neutron activation analysis has been utilized to establish the elemental concentrations of up to 37 chemical elements for each of 53 archeological pottery samples from medieval Cairo, Egypt, and one additional sample of Chinese porcelain. These elemental concentrations have been utilized in a statistical analysis procedure in order to determine similarities and correlations between the various samples. Multivariate analyses have been used to quantitatively determine these interrelationships. This methodology successfully separated the Egyptian samples into two broad categories: polychrome decorated ceramic ware and monochrome celadon ware. In addition the methodology successfully identified the one unique sample of Chinese porcelain. Several samples appeared to be either a mixture of categories or outliers in the data set and were not attributable to any distinct category. (author)

  16. Aerosol properties and associated radiative effects over Cairo (Egypt)

    Science.gov (United States)

    El-Metwally, M.; Alfaro, S. C.; Wahab, M. M. Abdel; Favez, O.; Mohamed, Z.; Chatenet, B.

    2011-02-01

    Cairo is one of the largest megacities in the World and the particle load of its atmosphere is known to be particularly important. In this work we aim at assessing the temporal variability of the aerosol's characteristics and the magnitude of its impacts on the transfer of solar radiation. For this we use the level 2 quality assured products obtained by inversion of the instantaneous AERONET sunphotometer measurements performed in Cairo during the Cairo Aerosol CHaracterization Experiment (CACHE), which lasted from the end of October 2004 to the end of March 2006. The analysis of the temporal variation of the aerosol's optical depth (AOD) and spectral dependence suggests that the aerosol is generally a mixture of at least 3 main components differing in composition and size. This is confirmed by the detailed analysis of the monthly-averaged size distributions and associated optical properties (single scattering albedo and asymmetry parameter). The components of the aerosol are found to be 1) a highly absorbing background aerosol produced by daily activities (traffic, industry), 2) an additional, 'pollution' component produced by the burning of agricultural wastes in the Nile delta, and 3) a coarse desert dust component. In July, an enhancement of the accumulation mode is observed due to the atmospheric stability favoring its building up and possibly to secondary aerosols being produced by active photochemistry. More generally, the time variability of the aerosol's characteristics is due to the combined effects of meteorological factors and seasonal production processes. Because of the large values of the AOD achieved during the desert dust and biomass burning episodes, the instantaneous aerosol radiative forcing (RF) at both the top (TOA) and bottom (BOA) of the atmosphere is maximal during these events. For instance, during the desert dust storm of April 8, 2005 RF BOA, RF TOA, and the corresponding atmospheric heating rate peaked at - 161.7 W/m 2, - 65.8 W/m 2

  17. A Parametric Urban Design Approach to Urban Development in Cairo

    DEFF Research Database (Denmark)

    Steinø, Nicolai

    2016-01-01

    -designer professionals can provide input and evaluate the spatial effects instantly in the context of participatory design processes. Cairo, Egypt, currently experiences rapid urban growth, while formal urban planning is absent in large parts, resulting in large-scale informal and unplanned development. A parametric...... in the course of participatory processes, as the consequences of changing different parameters cannot easily be evaluated by means of traditional design tools. In recent years, new parametric design tools have opened up new possibilities for dynamic scenario building in urban design. By way of a...... parametric design approach, different urban design parameters can be modified and new urban space scenarios can be rendered three-dimensionally in almost real time. In short, this is parametric urban design. It opens up completely new possibilities for participatory design, as both lay stakeholders and non...

  18. The 1992 'cairo earthquake': cause, effect and response.

    Science.gov (United States)

    Degg, M

    1993-09-01

    This paper examines the geological and socio-political setting of the 1992 earthquake in northern Egypt. The main conclusions concern the importance of surface geology in controlling the nature of the earthquake impact, and the role of poor construction and maintenance standards (and lapses in building regulation enforcement) in influencing the vulnerability of buildings to failure. The heaviest human losses were associated with two main types of construction: firstly the old, dilapidated adobe houses of the poor in rural areas and in Cairo's inner city slums, and secondly certain modern, engineered (in some cases illegally) high-rise concrete constructions inhabited by the wealthy. The paper concludes by analysing the immediate response of the government and some non-governmental organisations in Egypt to the earthquake. Politicisation of the event is linked to broader issues of economic and social reform in the country and to the rise of Islamic Fundamentalist activity in all its forms. PMID:20958770

  19. Magneto-deformation analysis of Great Cairo, Egypt

    International Nuclear Information System (INIS)

    Complete text of publication follows. Detecting crustal movements using of the Global positioning system (GPS) has been applied at different seismically active Areas. Egypt is recognized as a moderate earthquake activity region with frequent moderate events. Most of its seismicity is concentrated northern Egypt and around Great Cairo. In order to monitor crustal deformation around Great Cairo, a local geodetic network consists of 8 geodetic points were established in 2004, around potential faults. Four campaigns were performed and processed using Bernese GPS software. The aim of this study is to determine the tectonic elements presented and spot light upon the geodynamic regime of the area. The magnetic results revealed that the main structural trends are NW and NNW. These trends indicate that Red Sea major fault systems have strong influence on the mechanism of rifting that control the present-day deformation. In addition to main Red Sea orientation, predominant NE (Dead Sea-Aqaba trend) and E-W (Tethyan trend) were prevailed. The velocity vectors for each epoch of observations were calculated and deformation analysis was performed. The horizontal velocity varies between 1 and 8 mm/year in average across the network. The results of the deformation analysis indicate significant contraction and extension across the southeastern part of the study area while, the southwestern part is characterized by an extension strain rates. Also, northeastern part is characterized by significant contraction. The tendency of increasing strain amount resulted from deformation analysis in some locations because of the stress accumulation considered as a precursory for certain earthquake events could be occurred in the study area.

  20. Environmental and Occupational Lead Exposure Among Children in Cairo, Egypt

    Science.gov (United States)

    Moawad, Eman Mohamed Ibraheim; Badawy, Nashwa Mostafa; Manawill, Marie

    2016-01-01

    Abstract The aim of this study was to assess childhood lead exposure in a representative sample of Cairo, and to investigate the possible risk factors and sources of exposure. This cross-sectional study was conducted from November 2014 through April 2015. The target population was children aged 6 to 18 years, recruited into 4 groups, garbage city, moderate-living standard area, urban and suburban schools, and workshops in the city of Cairo. Blood lead levels (BLLs) and hemoglobin (Hb) concentrations were measured. Also, potential local environmental sources were assessed for hazardous lead contamination. Analysis on 400 participants has been carried out. A total of 113 children had BLLs in the range 10 to 20 μg/dL. Smoking fathers, housing conditions, playing outdoors, and exposure to lead in residential areas were significantly correlated with high BLLs. The mean values of hemoglobin were inversely correlated with BLLs. Children involved in pottery workshops had the highest BLLs and the lowest Hb values with a mean of (43.3 μg/dL and 8.6 g/dL, respectively). The mean value of environmental lead in workshop areas exceeded the recommended levels. Also, those values measured in dust and paint samples of garbage city were significantly high. Moreover, the mean lead levels in the soil samples were significantly higher in urban schools (P = 0.03) than the suburban ones. Childhood lead poisoning accounts for a substantial burden in Egypt, which could be preventable. Development of national prevention programs including universal screening program should be designed to reduce incidence of lead toxicity among children. PMID:26945415

  1. Virtual telepathology in Egypt, applications of WSI in Cairo University.

    Science.gov (United States)

    Ayad, Essam

    2011-01-01

    Telepathology, the practice of pathology at a long distance, has advanced continuously since 1986. Today, fourth-generation telepathology systems, so-called virtual slide telepathology systems, are being used for education applications. Both conventional and innovative surgical pathology diagnostic services are being designed and implemented as well. We have a successful experience in Egypt in applying the static & dynamic techniques in a pilot project between the Italian Hospital in Cairo (NPO) and the Civico Hospital in Palermo This project began in 2003 and continued till now. In 2004, centers in Venice, London and Pittsburgh participated actively in our project. During the past seven years we consulted on many problematic pathological cases with these different specialized pathological centers in Italy, UK & USA. In addition to the highly specialized scientific value of consulting on the cases and exchanging knowledge, we saved a lot of time and money and succeeded in providing our patients with a better medical service. In view of this success we have already established a new Digital Telepathology unit (DTU) in the pathology department, Cairo University, using the latest technique of telepathology which is Whole Slide Imaging (WSI) since one year. This unit is considered the first Digital pathology unit in all the universities of the whole Middle East. During the passed year we created a digital pathology library for the under graduate students using the WSI technique and changed the teaching method of the histopathology slides to be completely digital. We are building another digital pathology library (for post graduate candidates) which will be available to all pathology candidates in Egyptian universities & universities in the surrounding Arabic countries. We are also creating a digital pathology network between pathology centers in the Middle East for exchanging knowledge & telepathology. PMID:21489180

  2. Adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations and breast cancer risk.

    Science.gov (United States)

    Harris, Holly R; Bergkvist, Leif; Wolk, Alicja

    2016-06-01

    The World Cancer Research Fund/American Association for Cancer Research (WCRF/AICR) has published eight nutrition-related recommendations for the prevention of cancer. However, few prospective studies have examined these recommendations by breast cancer hormone receptor subtype and only one case-control study has included the dietary supplements recommendation in their evaluation. We investigated whether adherence to the WCRF/AICR cancer prevention recommendations was associated with breast cancer incidence, overall and by hormone receptor subtype, in the Swedish Mammography Cohort. Among 31,514 primarily postmenopausal women diet and lifestyle factors were assessed with a self-administered food frequency questionnaire. A score was constructed based on adherence to the recommendations for body fatness, physical activity, energy density, plant foods, animal foods, alcoholic drinks and dietary supplements (score range 0-7). Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs). During 15 years of follow-up 1,388 cases of breast cancer were identified. Women who met six to seven recommendations had a 51% decreased risk of breast cancer compared to women meeting only zero to two recommendations (95% CI = 0.35-0.70). The association between each additional recommendation met and breast cancer risk was strongest for the ER-positive/PR-positive subtype (HR = 0.86; 95% CI = 0.79-0.94), while for the ER-negative/PR-negative subtype the individual recommendations regarding plant and animal foods were most strongly associated with reduced risk. Our findings support that adherence to the WCRF/AICR recommendations reduces breast cancer risk in a population of primarily postmenopausal women. Promoting these recommendations to the public could help reduce breast cancer incidence. PMID:26804371

  3. Plant collecting program in Southeast Asia under the sponsorship of the United States National Cancer Institute (NCI) (1986-1991)

    OpenAIRE

    Soejarto, D. D.

    1992-01-01

    Under the funding from the United States National Cancer Institute (NCI)¹, a program was undertaken to collect plant samples in Southeast Asia to be tested for their cancer- and AIDS-arresting properties, for the period of September 1, 1986 through August 31, 1991. The program was implemented with the collaboration of the Arnold Arboretum and the Bishop Museum. Botanists from these and other institutions collaborated in the field work operation for the program, among others: J.S. BURLEY (A), ...

  4. Lumboaortic radiotherapy in patients with cervical cancer. Experience of the National Cancer Institute

    International Nuclear Information System (INIS)

    Background: Uterine cancer is still a prevalent disease in Chile. Is common to treat patients with tumors in stages IIB and IIIB where the risk of pelvic and paraortic limph node involvement is very high. Its treatment is radio-chemotherapy. Objective: To present a retrospective analysis of patients that suffered cervix-uterine cancer who were treated with radiotherapy including the aortic-lumbar area. Methods: From the revision of patients who were treated of cervix-uterine cancer between the years 1995 and 2007, 39 were treated including aortic-lumbar chains. Evolution and toxicity were analyzed. Two radiotherapy techniques were used. The first one, during the nineties, included two parallel previous and later and opposed fields, and a second technique, currently used, where pelvis and paraortic are radiated at the same time through four lateral (AP-PA) fields. Results: The dosimeter analysis of both techniques shows that there is a higher volume of radiated normal tissue with the two fields techniques, mainly in the small bowel. On the other hand, the toxicity was significantly different being today's technique less toxic and showing low gastrointestinal

  5. Plant collecting program in Southeast Asia under the sponsorship of the United States National Cancer Institute (NCI) (1986-1991)

    NARCIS (Netherlands)

    Soejarto, D.D.

    1992-01-01

    Under the funding from the United States National Cancer Institute (NCI)¹, a program was undertaken to collect plant samples in Southeast Asia to be tested for their cancer- and AIDS-arresting properties, for the period of September 1, 1986 through August 31, 1991. The program was implemented with t

  6. Patterns of care for ovarian cancer patients at Institute of Nuclear Medicine and Oncology (INMOL) Lahore

    International Nuclear Information System (INIS)

    The study was carried out to analyze the incidence of ovarian cancer and changing patterns of therapy during the last six years at INMOL (Institute of Nuclear Medicine and Oncology, Lahore Pakistan). Main objective was to review the results of treatment given and find out the causes of failure. Treatment and its outcome was also recorded to correlate the results with histological subtype and stage of diseases. It has been studied various factors like age of presentation, parity, social class, family history, method of surgery, stage of disease along with histologic type of the tumor. Epithelial ovarian cancer is not curable at advanced stages. Efforts should be made to find out some effective screening procedures for early detection. (Orig./A.B.)

  7. Male breast cancer: a report of 127 cases at a Moroccan institution

    Directory of Open Access Journals (Sweden)

    Tijami Fouad

    2011-06-01

    Full Text Available Abstract Background Male breast cancer (MBC is a rare disease representing less than 1% of all malignancies in men and only 1% of all incident breast cancers. Our study details clinico-pathological features, treatments and prognostic factors in a large Moroccan cohort. Findings One hundred and twenty-seven patients were collected from 1985 to 2007 at the National Institute of Oncology in Rabat, Morocco. Median age was 62 years and median time for consultation 28 months. The main clinical complaint was a mass beneath the areola in 93, 5% of the cases. Most patients have an advanced disease. Ninety-one percent of tumors were ductal carcinomas. Management consisted especially of radical mastectomy; followed by adjuvant radiotherapy and hormonal therapy with or without chemotherapy. The median of follow-up was 30 months. The evolution has been characterized by local recurrence; in twenty two cases (17% of all patients. Metastasis occurred in 41 cases (32% of all patients. The site of metastasis was the bone in twenty cases; lung in twelve cases; liver in seven case; liver and skin in one case and pleura and skin in one case. Conclusion Male breast cancer has many similarities to breast cancer in women, but there are distinct features that should be appreciated. Future research for better understanding of this disease at national or international level are needed to improve the management and prognosis of male patients.

  8. [The (German) Center for Cancer Registry Data (ZfKD) at the Robert Koch Institute (RKI) in Berlin].

    Science.gov (United States)

    Wolf, U; Barnes, B; Bertz, J; Haberland, J; Laudi, A; Stöcker, M; Schönfeld, I; Kraywinkel, K; Kurth, B-M

    2011-11-01

    Cancer represents the second most common cause of death in Germany. The country's federal states operate regional population-based cancer registries that collect and analyze data on cancer patients. This provides an essential basis for describing the cancer burden in the German population. In order to obtain valid and reliable information on cancer incidence at the national level, the Robert Koch Institute (RKI) set up the Federal Cancer Surveillance Unit in 1983 as a central institution for evaluating this cancer registry data. In August 2009, when the Federal Cancer Registry Data Act (BKRG) came into force, the Center for Cancer Registry Data (ZfKD) at the RKI took over the work of the Cancer Surveillance Unit with a broader remit. In the future, it will also regularly publish findings on survival, prevalence, and tumor stage distribution. A newly established record linkage process will help identify multiple submissions from the federal states. Further innovations and new tasks of the ZfKD include expanding an interactive Internet platform and encouraging a more intensive use of cancer registry data for epidemiological research by providing datasets to external scientists. The range of information available to the interested public is also to be expanded. PMID:22015795

  9. Preliminary Analysis of Difficulty of Importing Pattern-Based Concepts into the National Cancer Institute Thesaurus.

    Science.gov (United States)

    He, Zhe; Geller, James

    2016-01-01

    Maintenance of biomedical ontologies is difficult. We have developed a pattern-based method for dealing with the problem of identifying missing concepts in the National Cancer Institute thesaurus (NCIt). Specifically, we are mining patterns connecting NCIt concepts with concepts in other ontologies to identify candidate missing concepts. However, the final decision about a concept insertion is always up to a human ontology curator. In this paper, we are estimating the difficulty of this task for a domain expert by counting possible choices for a pattern-based insertion. We conclude that even with support of our mining algorithm, the insertion task is challenging. PMID:27577410

  10. Acanthamoeba species in Swimming Pools of Cairo, Egypt.

    Directory of Open Access Journals (Sweden)

    Ahmad Al-Herrawy

    2014-06-01

    Full Text Available The free-living amoebae Acanthamoeba spp. have been recognized as etiologic agents of amoebic encephalitis, keratitis, otitis, lung lesions and other skin infections mainly in immuno-compromised individuals. The purpose of this study is to detect the presence of Acanthamoeba in swimming pools in Egypt using a polymerase chain reaction (PCR method.Water samples were collected from 10 different swimming pools in Cairo, Egypt. Samples were cultured on non-nutrient agar for the detection of Acanthamoeba isolates that were confirmed by PCR amplification using genus specific primers. The molecularly confirmed Acanthamoeba isolates were morphologically identified to the species level.Members of genus Acanthamoeba were detected in 49.2% of the examined swimming-pool water samples. Morphologically, six Acanthamoeba species were isolated from the examined swimming pool water namely A. polyphaga, A.castellanii, A. rhysodes, A. mauritaniensis, A. royreba and A. triangularis. All the identified species of Acanthamoeba were molecularly confirmed to be related to the genus Acanthamoeba.The isolated species of Acanthamoeba could provoke variable degrees of infections to the swimmers. The culture method is cheaper and easier than PCR techniques that are faster for the detection of free-living amoebae.

  11. Detailed magnetic survey at Dahshour archeological sites Southwest Cairo, Egypt

    Science.gov (United States)

    Mekkawi, Mahmoud; Arafa-Hamed, Tarek; Abdellatif, Tareq

    2013-06-01

    Dahshour area has recently shown a great potential of archeological findings. This was remarkable from the latest discovery of the causeway and the mortuary temple of the Pyramid of Amenemhat III using geophysical data. The main objective of the present work is to locate the buried archeological remains in the area of Dahshour, Southwest Cairo using magnetic survey for shallow investigations. Land magnetic data is acquired using proton magnetometer (two sensors) with a sensor separation of 0.8 m; i.e. gradiometer survey. The study area is located nearby the two known pyramids of Dahshour. The field data is processed and analyzed using Oasis Montaj Geosoft™ software. The processed data is presented in order to delineate the hidden artifacts causing the magnetic anomalies. The results indicated a distribution of the buried archeological features within the study area. These archeological features are detected according to the magnetic contrast between the magnetic archeological sources (such as mud bricks, basalt and granite) and the surroundings; mainly sandy soil. The delineated archeological features at Dahshour are probably dated back to the old kingdom having a depth reach up to 3.0 m. Consequently it is highly recommended to carry out excavation to precisely classify them and high light their nature and value.

  12. The Cairo Fourier Diffractometer Facility At The ETRR-1 Reactor

    International Nuclear Information System (INIS)

    The work presents the Cairo Fourier diffractometer facility (CFDF). The CFDF is based on the reverse time-of-flight (RTOF) concept and was recently installed, as IAEA TC Project, at one of the ET-RR-1 reactor horizontal channels. The CFDF performance is assessed and its main parameters are given. The facility applies a Fourier chopper system and 6Li-glass scintillators (NE-912) arranged according to the time focusing geometry in order to detect neutrons scattered from the sample at an angle 29= 90 diameter. The detector system has been optimized for studying the internal stresses in materials along with neutron diffraction measurements. Its angular aperture was found, from precise calculations, by a special program, to be equal to S.1 x 102 steradians. The neutron guide system attached to the CFDF provides a thermal neutron flux-l.lxl06n/cm2/sec at the sample position. It has been found, from measurements with different powder samples, that such value of the thermal neutron flux is adequate for neutron diffraction measurements, at scattering angle 2θ= 90ο and d-spacing values between 0.7 A and 2.5 A, within 0.45% resolution

  13. Source process of the October 12, 1992 Cairo earthquake

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    H. M. Hussein

    1999-06-01

    Full Text Available Broadband body waves recorded at 12 digital seismic stations worldwide were used to study the source process of the October 12, 1992 Cairo earthquake. To study the source process of this event the P and SH waveforms from IRIS data center were inverted to double couple source using the method Kikuchi and Kanamori (1991 in which the rupture is presented by discrete subevents with various mechanisms. The best solution consists of only one event with a mechanism 270°/47°/-123° (strike/dip/slip, a normal faulting mechanism with small strike slip component. This solution is almost compatible with the previously suggested mechanisms for the same event. This event took place at a depth of 22 km. This depth explains the lack of surface faulting. The seismic moment is 7.2 ´ 10 17 Nm (Mw = 5.8 with a source duration of 4 s. The estimated fault length is about 11 km, the derived average dislocation (D is 0.24 m, the stress drop (Ds is 1.85 MPa and the Orwan stress drop is 0.425 MPa.

  14. Research Studies Performed Using the Cairo Fourier Diffractometer Facility

    Science.gov (United States)

    Maayouf, R. M. A.

    2013-03-01

    This report represents the results of research studies performed using the Cairo Fourier diffractometer facility (CFDF), within 10 years after it was installed and put into operation at the beginning of 1996. The main components of the CFDF were supplied by the IAEA according to the technical assistance project EGY/1/022. Plenty of measurements were performed, since then; yielding several publications, both in local and international scientific periodicals; and 8 M.Sc. & Ph.D. degrees from Egyptian Universities. Besides, a new approach for the analysis of the neutron spectra measured using the CFDF; applying especially designed interface card, along with its proper software program, instead of the reverse time of flight (RTOF), Finnish make, analyzer originally attached to the facility. It has been verified that the new approach cnn successfully replace the RTOF analyzer; significantly decreasing the time of measurement; and saving the reactor's operation time. A special fault diagnostic system program was developed and tested for caring and handling the possible failures of the CFDF. Besides the new developments required for the CFDF for industrial applications in wide scale, are also considered.

  15. Quality of life among young women with breast cancer: Study from a tertiary cancer institute in south India

    Directory of Open Access Journals (Sweden)

    B Dubashi

    2010-01-01

    Full Text Available Background : The incidence of breast cancer in young patients less than 35 years is less than 1%. The physical and psychosocial morbidity may affect their ability to successfully function in their social roles. Hence we studied the quality of life (QOL issues in this subset. Materials and Methods :Younger women with age less than 35 years, diagnosed with non-metastatic breast cancer at our Institute, from 1995 to 2005, were included in the study. Quality of life issues were studied during the follow-up using EORTC QOL C30 and BR23. Descriptive and inferential statistics were used in order to analyze the data. Results : A total of 51 patients were included for the study. The mean age at diagnosis was 30 years. The effect of breast cancer on the occupation and marital status was minimal. The global health status and the functional scores were high, while the overall sexual function was lower. The global health status was higher in the mastectomy group. The arm symptoms (P = 0.027 and pain were higher in the Breast conservation surgery (BCS group. The sexual symptoms appeared to be higher in the ovary ablated group when compared to the ovary preserved group. The sexual functional scores (P = 0.02 and sexual enjoyment scores (P = 0.003 were better in the mastectomy group. Conclusion : The overall QOL in younger patients with breast cancer appeared to be good. The QOL and sexual function were marginally worse in the breast conservation group when compared to mastectomy group.

  16. Endobronchial Ultrasound Changed the World of Lung Cancer Patients: A 11-Year Institutional Experience.

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    Chia-Hung Chen

    Full Text Available The role of advanced bronchoscopic diagnostic techniques in the detection and staging of lung cancer has increased sharply in recent years. The development of endobronchial ultrasound (EBUS improved minimally invasive mediastinal staging and diagnosis of peripheral lung lesions (PLLs. We investigated the impact of using EBUS as a diagnostic method for tissue acquisition in lung cancer patients.In a single center observational retrospective study, 3712 subjects were diagnosed with lung cancer from 2003 to 2013 (EBUS was introduced in 2008. Thus, we divided the data into two periods: the conventional bronchoscopy period (2003 to 2007 and the EBUS period (2008 to 2013.A total of 3712 patients were included in the analysis. Comparing the conventional bronchoscopy period with the EBUS period data, there has been a significant reduction in the use of diagnostic modalities: CT-guided biopsy (P < 0.0001 and pleural effusion cytology (P < 0.0001. The proportion of subjects diagnosed using bronchoscopy significantly increased from 39.4% in the conventional period to 47.4% in the EBUS period (P < 0.0001. In the EBUS period, there has also been a significant increase in the proportion of patients proceeding directly to diagnostic surgery (P < 0.0001. Compared to bronchoscopy, the incidence of complications was higher in those who underwent CT guide biopsy. The incidence of iatrogenic pneumothorax significantly decreased in the EBUS period.Advanced bronchoscopic techniques are widely used in the diagnosis of lung cancer. At our institution, the increasing use of EBUS for providing lung cancer diagnosis has led to a significant reduction in other diagnostic modalities, namely CT-guided biopsy and pleural effusion cytology. These changes in practice also led to a reduction in the incidence of complications.

  17. Environmental dose in the Nuclear Medicine Department of the National Institute of Cancer

    International Nuclear Information System (INIS)

    The dosimeters TLD-100 and TLD-900 were used to know the levels of environmental dose in areas of the Nuclear Medicine Department of the National Institute of Cancer. The dosimeters calibration was carried out in the Metrology Department of the National Institute of Nuclear Research. The radioisotopes used in the studied areas are 131I, 18F, 67Ga, 99mTc, 111In, 201Tl and 137Cs with gamma energies between 93 and 662 KeV. Dosimeters were placed during five months in the diagnostic, injection, waiting and PET rooms as well as hot room, waste room, enclosed corridors to patient rooms treated with 131I and 137Cs and witness dosimeters to know the bottom. The values found vary between 0.3 and 70 major times that those of bottom. The maximum doses were measured in the waste room and in the enclosed corridor to the patient rooms with cervical uterine cancer treated with 137Cs. (Author)

  18. Radiation therapy with or without primary limited surgery for operable breast cancer: A 20-year experience at the Marseilles Cancer Institute

    International Nuclear Information System (INIS)

    At the Marseilles Cancer Institute, the authors' first source of radioactive cesium was promptly applied to the treatment of breast cancer, to which it seemed ideally suited because of good superficial and intermediate penetration. Their favorable early experience led them to embark on a program of conservative treatment of operable breast cancer, which has supplanted the routine use of radical mastectomy at our institution. Since June 1960, more than 3000 consecutive operable breast cancers were treated primarily with radiation therapy with or without initial limited surgery. This paper presents the treatment results in 1440 cases eligible for five-year analysis, including 320 ten-year cases, thus representing the largest series of breast cancer patients treated with modern radiation therapy techniques thus far reported in the literature

  19. Elasticity of CaIrO3 with perovskite and post-perovskite structure

    Science.gov (United States)

    Niwa, Ken; Yagi, Takehiko; Ohgushi, Kenya

    2011-01-01

    Compression behaviors of CaIrO3 with perovskite (Pv) and post-perovskite (pPv) structures have been investigated up to 31.0(1.0) and 35.3(1) GPa at room temperature, respectively, in a diamond-anvil cell with hydrostatic pressure media. CaIrO3 Pv and pPv phases were compressed with the axial compressibility of β a > β c > β b and β b > β a > β c, respectively and no phase transition was observed in both phases up to the highest pressure in the present study. The order of axial compressibility for pPv phase is consistent with the crystallographic consideration for layer structured materials and previous experimental results. On the other hand, Pv phase shows anomalous compression behavior in b axis, which exhibit constant or slightly expanded above 13 GPa, although the applied pressure remained hydrostatic. Volume difference between Pv and pPv phases was gradually decreased with increasing pressure and this is consistent with the results of theoretical study based on the ab initio calculation. Present results, combined with theoretical study, suggest that these complicate compression behaviors in CaIrO3 under high pressure might be caused by the partially filled electron of Ir4+. Special attention must be paid in case of using CaIrO3 as analog materials to MgSiO3, although CaIrO3 exhibits interesting physical properties under high pressure.

  20. Cost comparison of curative therapies for localized prostate cancer in Japan. A single-institution experience

    International Nuclear Information System (INIS)

    In addition to open surgery, curative therapies for prostate cancer now include endoscopic surgery and radiation therapies. Because of the expansion and subdivision of treatment methods for prostate cancer, the medical fee point schedule in Japan was revised in fiscal year 2006. We examined changes in medical income and expenditure after this revision of the medical fee system. We studied income and expenditure, after institution of the new medical fee schedule, for the five types of therapies for prostate cancer performed at our hospital: two surgical therapies (radical retropubic prostatectomy and laparoscopic prostatectomy) and three radiation therapies (three-dimensional conformal radiation therapy, 192Ir high-dose-rate brachytherapy, and 125I low-dose-rate brachytherapy). Low-dose-rate brachytherapy was found to be associated with a profit of 199 yen per patient. Laparoscopic prostatectomy, a highly advanced medical treatment that the fee revision changed from a partially insured to an insured procedure, yielded a profit of 75672 yen per patient. However, high-dose-rate brachytherapy was associated with a loss of 654016 yen per patient. Given the loss in hospital income per patient undergoing high-dose-rate brachytherapy, the medical fee point system for this procedure should be reassessed. (author)

  1. Altered plasma apolipoprotein modifications in patients with pancreatic cancer: protein characterization and multi-institutional validation.

    Directory of Open Access Journals (Sweden)

    Kazufumi Honda

    Full Text Available BACKGROUND: Among the more common human malignancies, invasive ductal carcinoma of the pancreas has the worst prognosis. The poor outcome seems to be attributable to difficulty in early detection. METHODS: We compared the plasma protein profiles of 112 pancreatic cancer patients with those of 103 sex- and age-matched healthy controls (Cohort 1 using a newly developed matrix-assisted laser desorption/ionization (oMALDI QqTOF (quadrupole time-of-flight mass spectrometry (MS system. RESULTS: We found that hemi-truncated apolipoprotein AII dimer (ApoAII-2; 17252 m/z, unglycosylated apolipoprotein CIII (ApoCIII-0; 8766 m/z, and their summed value were significantly decreased in the pancreatic cancer patients [P = 1.36×10(-21, P = 4.35×10(-14, and P = 1.83×10(-24 (Mann-Whitney U-test; area-under-curve values of 0.877, 0.798, and 0.903, respectively]. The significance was further validated in a total of 1099 plasma/serum samples, consisting of 2 retrospective cohorts [Cohort 2 (n = 103 and Cohort 3 (n = 163] and a prospective cohort [Cohort 4 (n = 833] collected from 8 medical institutions in Japan and Germany. CONCLUSIONS: We have constructed a robust quantitative MS profiling system and used it to validate alterations of modified apolipoproteins in multiple cohorts of patients with pancreatic cancer.

  2. Pelvic exenteration for colorectal cancer: oncologic outcome in 59 patients at a single institution

    International Nuclear Information System (INIS)

    Pelvic exenteration (PE) continues to be the only curative option in selected patients with advanced or recurrent pelvic neoplasms. A current debate exists concerning the appropriate selection of patients for PE, with the most important factor being the absence of extrapelvic disease. To evaluate the outcome of patients submitted to exenterative surgery. A review of the clinical charts of patients with colorectal cancer who underwent PE between January 1994 and June 2010 at the Institute National of Cancerología in Mexico City was performed. We selected 59 patients, 53 of whom were females (90%), and six of whom were males (10%). Mean age at the time of diagnosis was 50 years (range, 21–77 years). A total of 51 patients underwent posterior PE (86%), and eight patients underwent total PE (14%). Operative mortality occurred in two cases (3%), and 29 patients developed complications (49%). Overall, 11 patients (19%) experienced local failure with mean disease-free survival time of 10.2 months. After a mean follow-up of 28.3 months, nine patients are still alive without evidence of the disease (15%). PE should be considered in advanced colorectal cancer without extrapelvic metastatic disease. PE is accompanied by considerable morbidity (49%) and mortality (3%), but local control is desirable. Overall survival justifies the use of this procedure in patients with primary or recurrent locally advanced rectal cancer

  3. The National Cancer Institute's PREVENT Cancer Preclinical Drug Development Program: overview, current projects, animal models, agent development strategies, and molecular targets.

    Science.gov (United States)

    Shoemaker, Robert H; Suen, Chen S; Holmes, Cathy A; Fay, Judith R; Steele, Vernon E

    2016-02-01

    The PREVENT Cancer Preclinical Drug Development Program (PREVENT) is a National Cancer Institute, Division of Cancer Prevention (NCI, DCP)-supported program whose primary goal is to bring new cancer preventive interventions (small molecules and vaccines) and biomarkers through preclinical development towards clinical trials by creating partnerships between the public sector (eg, academia, industry) and DCP. PREVENT has a formalized structure for moving interventions forward in the prevention pipeline using a stage-gate process with go/no go decision points along the critical path for development. This review describes the structure of the program, its focus areas, and provides examples of projects currently in the pipeline. PMID:26970137

  4. Creating a “culture of research” in a community hospital: Strategies and tools from the National Cancer Institute Community Cancer Centers Program

    Science.gov (United States)

    St. Germain, Diane; Nacpil, Lianne M; Zaren, Howard A; Swanson, Sandra M; Minnick, Christopher; Carrigan, Angela; Denicoff, Andrea M; Igo, Kathleen E; Acoba, Jared D; Gonzalez, Maria M; McCaskill-Stevens, Worta

    2015-01-01

    Background The value of community-based cancer research has long been recognized. In addition to the National Cancer Institute’s Community Clinical and Minority-Based Oncology Programs established in 1983, and 1991 respectively, the National Cancer Institute established the National Cancer Institute Community Cancer Centers Program in 2007 with an aim of enhancing access to high-quality cancer care and clinical research in the community setting where most cancer patients receive their treatment. This article discusses strategies utilized by the National Cancer Institute Community Cancer Centers Program to build research capacity and create a more entrenched culture of research at the community hospitals participating in the program over a 7-year period. Methods To facilitate development of a research culture at the community hospitals, the National Cancer Institute Community Cancer Centers Program required leadership or chief executive officer engagement; utilized a collaborative learning structure where best practices, successes, and challenges could be shared; promoted site-to-site mentoring to foster faster learning within and between sites; required research program assessments that spanned clinical trial portfolio, accrual barriers, and outreach; increased identification and use of metrics; and, finally, encouraged research team engagement across hospital departments (navigation, multidisciplinary care, pathology, and disparities) to replace the traditionally siloed approach to clinical trials. Limitations The health-care environment is rapidly changing while complexity in research increases. Successful research efforts are impacted by numerous factors (e.g. institutional review board reviews, physician interest, and trial availability). The National Cancer Institute Community Cancer Centers Program sites, as program participants, had access to the required resources and support to develop and implement the strategies described. Metrics are an important

  5. A 20 years evaluation of cancer of the tongue at cancer institute Imam Khomeini Hospital, 1978-98

    Directory of Open Access Journals (Sweden)

    Mir M

    2001-08-01

    Full Text Available Informations regarding 152 patients of cancer of tongue in cancer institute from 1978 to 1998 was collected and analyzed. From these cases, 53.3 percent were male with a mean age of 54.49 years (SD=16.23 and the mean age of female was 2.5 years more than of male. Positive lymphadenopathy in men was positive and significantly more than that of female (P<0.05. The physical appearance of the tumor was ulcerative (66.7 percent. Most of the referrals were in the range of T1 (62.8 percent and were operated. Information from 88 patients was evaluated and it was found that 23.9 percent of the patients has died. One year survival was 92.05 percent and 3 years survival 83.3 percent and it was confirmed that advanced stage of the illness decreases the survival rate (P<0.001.      

  6. Locally advanced cervix cancer: chemotherapy prior to definitive surgery or radiotherapy. A single institutional experience

    International Nuclear Information System (INIS)

    Primary or neoadjuvant chemotherapy prior to definitive local therapy has potential advantages for locally advanced cervix cancer. It can down stage a cancer and allow definitive local therapy to be technically possible (surgery), or potentially more effective (radiotherapy). It can also eradicate subclinical systemic metastases. This report reviews a single institution's experience of neoadjuvant chemotherapy prior to definitive local therapy for cervix cancer over a 13-year period. One hundred and six patients were treated with this intent. The patients were analysed for their response to chemotherapy, treatment received, survival, relapse and toxicity. The chemotherapy was feasible and the majority of patients had a complete or partial response (58.5%). Eight patients did not proceed to local treatment. Forty-six patients had definitive surgery and 52 had definitive radiotherapy. The 5-year overall survival was 27% and the majority of patients died with disease. The first site of relapse was usually in the pelvis (46.2%). Late complications that required ongoing medical therapy (n = 6) or surgical intervention (n = 2) were recorded in eight patients (7.5%). On univariate analysis stage (P= 0.04), tumour size (P = 0.01), lymph node status (P=0.003), response to chemotherapy (P = 0.045) and treatment (P = 0.003) were all significant predictors of survival. On multivariate analysis, tumour size (P < 0.0001) and nodal status (P = 0.02) were significant predictors of survival. Despite the impressive responses to chemotherapy of advanced cervix cancer, there is evidence from randomized trials that it does not improve or compromise survival prior to radiotherapy. As its role prior to surgery remains unclear, it should not be used in this setting outside a prospective randomized trial. Copyright (2001) Blackwell Science Pty Ltd

  7. Structure and elasticity of Cmcm CaIrO3 and their pressure dependences: Ab initio calculations

    Science.gov (United States)

    Tsuchiya, Taku; Tsuchiya, Jun

    2007-10-01

    Cmcm CaIrO3 is isostructural to the newly discovered high-pressure postperovskite polymorph of MgSiO3 . Due to the high transition pressure in MgSiO3 over 100GPa , low-pressure analoglike CaIrO3 is substantial to investigate physical properties of the postperovskite phase experimentally. Here we perform ab initio density functional calculations of structural and elastic properties of CaIrO3 phases and compare them with the results reported for MgSiO3 phases in detail. Local spin density approximation produces a Pauli-paramagnetic metallic ground state for Pbnm CaIrO3 , while a very weak but finite antiferromagnetic moment appears in Cmcm phase at 0GPa . We also find that each component of the normalized elastic stiffness constants of CaIrO3 is largely discrepant from that of MgSiO3 particularly in shear components, though CaIrO3 shows the compression behavior roughly similar to MgSiO3 . Those contrasts in shear constants cause the different shear wave anisotropy style. Results suggest that at least regarding shear wave polarization anisotropy, CaIrO3 is unlikely to be a good low-pressure analog of MgSiO3 , and care must be taken when one extrapolates the elastic property of Cmcm CaIrO3 to the MgSiO3 postperovskite.

  8. Growth of CaIrO3 and Gd2Ir2O7 by MBE

    Science.gov (United States)

    Nie, Yuefeng; Held, Rainer; Chatterjee, Shouvik; Monkman, Eric; Shai, Daniel; Harter, John; Burganov, Bulat; Adamo, Carolina; Schlom, Darrell; Shen, Kyle

    2012-02-01

    Recently, it was pointed out that the 5d transition metal iridium oxides (iridates) are promising candidates to realize topological insulators, which provide a unique platform in studying the interplay of Coulomb interactions, spin-orbit coupling, and the band topology of solids. We successfully grew epitaxial perovskite CaIrO3 and pyrochlore Gd2Ir2O7 films by reactive molecular-beam epitaxy (MBE). A range of biaxial strains for epitaxial CaIrO3 films was achieved by growing on different substrates. Angle-resolved photoemission spectroscopy (ARPES) will be used to investigate the electronic structure of the epitaxial CaIrO3 and Gd2Ir2O7 films.

  9. Semimetallic transport properties of epitaxially stabilized perovskite CaIrO3 films

    Science.gov (United States)

    Hirai, Daigorou; Matsuno, Jobu; Nishio-Hamane, Daisuke; Takagi, Hidenori

    2015-07-01

    We report on the synthesis and transport properties of perovskite (Pv) CaIrO3 thin films. The Pv phase of CaIrO3 was stabilized by epitaxial growth on SrTiO3, (LaAlO3)0.3(Sr2AlTaO6)0.7, and LaAlO3 substrates with strong tensile, weak tensile, and compressive strains, respectively. The resistivity of these films showed a poorly metallic behavior. The Hall resistivity exhibited a sign change as a function of temperature and a nonlinear magnetic-field dependence, which clearly indicated the coexistence of electrons and holes and hence supported that Pv CaIrO3 films are semimetallic. The observed robustness of the semimetallic ground state against tensile and compressive strains is consistent with the presence of symmetry-protected Dirac points (nodes) around the Fermi level that prohibits the system from becoming a band insulator.

  10. Mott insulator-to-metal transition in yttrium-doped CaIrO3

    Science.gov (United States)

    Gunasekera, J.; Chen, Y.; Kremenak, J. W.; Miceli, P. F.; Singh, D. K.

    2015-02-01

    We report on the study of insulator-to-metal transition in post-perovskite compound CaIrO3. It is discovered that a gradual chemical substitution of calcium by yttrium leads to the onset of strong metallic behavior in this compound. This observation is in stark contrast to BaIrO3, which preserves its Mott insulating behavior despite excess of the charge carriers due to yttrium doping. Magnetic measurements reveal that both compounds tend to exhibit magnetic character irrespective of the chemical substitution of Ca or Ba. We analyze these unusual observations in light of recent researches that suggest that CaIrO3 does not necessarily possess j = 1/2 ground state due to structural distortion. The insulator-to-metal transition in CaIrO3 will spur new researches to explore more exotic ground state, including superconductivity, in post-perovskite Mott insulators.

  11. Assessment of Indoor Radon Concentrations and Dose Equivalent to Population in Cairo City

    International Nuclear Information System (INIS)

    Radon comes from the natural radioactive of radium and uranium found in the soil beneath the house and from the building materials used. The amount of radon in the soil depends on complex soil chemistry that varies from one area to the next. The amount of radon that escapes from the soil and from the building materials and enters the house depends on the weather, soil porosity, soil moisture, and the ventilation within the house. Cairo is an expanding city and includes territories with different characteristics. Thus, in this work radon concentrations were evaluated in different territorial locations within Great cairo. These locations have been selected to investigate any possible differences in radon concentration between old, new residential, agricultural and industrial regions. Measurements were carried out using CR-39 as solid state nuclear track detector. The range of 222Rn activity in this survey was found in the range 8.71-50.18 Bq.m-3 in different locations in cairo

  12. Awareness and behavior of oncologists and support measures in medical institutions related to ongoing employment of cancer patients in Japan

    International Nuclear Information System (INIS)

    Improved outcomes of cancer treatment allow patients to undergo treatment while working. However, support from oncologists and medical institutions is essential for patients to continue working. This study aimed to clarify oncologists' awareness and behavior regarding patients who work during treatment, support in medical institutions and their association. A questionnaire was mailed to all 453 diplomates and faculty of the subspecialty board of medical oncology in the Japanese Society of Medical Oncology and all 1016 surgeons certified by the Japanese Board of Cancer Therapy living in the Kanto area. The questionnaire assessed demographics, oncologist awareness and behavior regarding patient employment and support measures at their medical institutions. Logistic regression analysis was used to examine the association of awareness and behavior of oncologists with support measures at their institutions. A total of 668 individuals participated. The overall response rate was 45.5%. Only 53.6% of respondents advised patients to tell their supervisors about prospects for treatment and ask for understanding. For medical institutions, 28.8% had a nurse-involved counseling program and adjustments in radiation therapy (28.0%) and chemotherapy (41.9%) schedules to accommodate patients' work. There was a significant correlation between awareness and behavior of oncologists and medical institutions' measures to support employed cancer patients. There is room for improvement in awareness and behavior of oncologists and support in medical institutions for cancer patients continuing to work. Oncologists could support working patients by exerting influence on their medical institutions. Conversely, proactive development of support measures by medical institutions could alter the awareness and behavior of oncologists. (author)

  13. Relationship of Internet health information use with patient behavior and self-efficacy: experiences of newly diagnosed cancer patients who contact the National Cancer Institute's Cancer Information Service.

    Science.gov (United States)

    Bass, Sarah Bauerle; Ruzek, Sheryl Burt; Gordon, Thomas F; Fleisher, Linda; McKeown-Conn, Nancy; Moore, Dirk

    2006-03-01

    This study examines the relationship of Internet health information use with patient behavior and self-efficacy among 498 newly diagnosed cancer patients. Subjects were classified by types of Internet use: direct use (used Internet health information themselves), indirect use (used information accessed by friends or family), and non-use (never accessing Internet information). Subjects were recruited from callers of the National Cancer Institute's (NCI's) Cancer Information Service, Atlantic Region. They were classified by type of Internet use at enrollment and interviewed by telephone after 8 weeks. There were significant relationships among Internet use and key study variables: subject characteristics, patient task behavior, and self-efficacy. Subjects' Internet use changed significantly from enrollment to 8 week follow-up; 19% of nonusers and indirect users moved to a higher level of Internet use. Significant relationships also were found among Internet use and perceived patient-provider relationship, question asking, and treatment compliance. Finally, Internet use was also significantly associated with self-efficacy variables (confidence in actively participating in treatment decisions, asking physicians questions, and sharing feelings of concern). The results of this study show that patients who are newly diagnosed with cancer perceive the Internet as a powerful tool, both for acquiring information and for enhancing confidence to make informed decisions. PMID:16537289

  14. Intraoperative radiation therapy at the National Cancer Institute: technical innovations and dosimetry

    International Nuclear Information System (INIS)

    The technical complexity of intraoperative radiotherapy (IORT) requires modification of the standard physical and dosimetric methods used in external electron beam therapy. At the National Cancer Institute, a number of technical innovations have been integrated into ongoing clinical studies of IORT. These include: (1) an electron beam applicator system that is significantly different from other IORT systems and includes customized squircle applicators; (2) peripheral dose shields; (3) a modified surgical table replacing the standard radiation treatment couch; and (4) routine use of multiple IORT fields that necessitates field matching. The IORT applicator system and related devices and techniques are dosimetrically characterized in detail both for use in the IORT program and in order to illustrate many useful facets of electron dosimetry

  15. Semimetallic transport properties of epitaxially stabilized perovskite CaIrO3 films

    OpenAIRE

    Hirai, Daigorou; Matsuno, Jobu; Takagi, Hidenori

    2015-01-01

    We report on the synthesis and transport properties of perovskite (Pv) CaIrO3 thin films. The Pv phase of CaIrO3 was stabilized by epitaxial growth on SrTiO3, (LaAlO3)0.3(Sr2AlTaO6)0.7, and LaAlO3 substrates with strong tensile, weak tensile, and compressive strains, respectively. The resistivity of these films showed a poorly metallic behavior. The Hall resistivity exhibited a sign change as a function of temperature and a nonlinear magnetic-field dependence, which clearly indicated the coex...

  16. First-principles study of the electronic structure and magnetism of CaIrO$_3$

    OpenAIRE

    Subedi, Alaska

    2011-01-01

    I study the electronic structure and magnetism of postperovskite CaIrO$_3$ using first-principles calculations. The density functional calculations within the local density approximation without the combined effect of spin-orbit coupling and on-site Coulomb repulsion show the system to be metallic, which is in disagreement with the recent experimental evidences that show CaIrO$_3$ to be an antiferromagnetic Mott insulator in the $J_\\textrm{eff}$ = 1/2 state. However, when spin-orbit coupling ...

  17. The Bone Marrow Transplantation Center of the National Cancer Institute - its resources to assist patients with bone marrow failure

    International Nuclear Information System (INIS)

    This paper describes the bone marrow transplantation center of the brazilian National Cancer Institute, which is responsible for the cancer control in Brazil. The document also describes the resources available in the Institute for assisting patients presenting bone marrow failures. The Center provides for allogeneic and autologous bone marrow transplants, peripheral stem cell transplants, umbilical cord collections and transplants, and a small experience with unrelated bone marrow transplants. The Center receives patient from all over the country and provides very sophisticated medical care at no direct cost to the patients

  18. Prophylactic cranial irradiation in patients with small-cell lung cancer: the experience at the Institute of Oncology Ljubljana:

    OpenAIRE

    Stanic, Karmen; Kovac, Viljem

    2010-01-01

    Background Prophylactic cranial irradiation (PCI) has been used in patients with small-cell lung cancer (SCLC) to reduce the incidence of brain metastases (BM) and thus increase overall survival. The aim of this retrospective study was to analyze the characteristics of patients with SCLC referred to the Institute of Oncology Ljubljana, their eligibility for PCI, patterns of dissemination, and survival. Patients and methods Medical charts of 357 patients with SCLC, referred to the Institute of...

  19. Medical care costs incurred by patients with smoking-related non-small cell lung cancer treated at the National Cancer Institute of Mexico

    OpenAIRE

    Arrieta, Oscar; Quintana-Carrillo, Roger Humberto; Ahumada-Curiel, Gabriel; Corona-Cruz, Jose Francisco; Correa-Acevedo, Elma; Zinser-Sierra, Juan; de la Mata-Moya, Dolores; Mohar-Betancourt, Alejandro; Morales-Oyarvide, Vicente; Reynales-Shigematsu, Luz Myriam

    2015-01-01

    Background Smoking is a public health problem in Mexico and worldwide; its economic impact on developing countries has not been well documented. The aim of this study was to assess the direct medical costs attributable to smoking incurred by lung cancer patients treated at the National Cancer Institute of Mexico (INCan). Methods The study was conducted at INCan in 2009. We carried out a cost of illness (COI) methodology, using data derived from an expert panel consensus and from medical chart...

  20. Iodine-125 seed brachytherapy for early stage prostate cancer: a single-institution review

    International Nuclear Information System (INIS)

    We are reporting the five-year biochemical control, toxicity profile and dosimetric parameters using iodine-125 low dose rate brachytherapy (BT) as monotherapy for early stage prostate cancer at a single institution. Between April 2006 and December 2010, 169 men with early stage prostate cancer were treated with BT. Biochemical failure was defined using the Phoenix definition (nadir + 2 ng/mL). Treatment-related morbidities, including urinary, rectal and sexual function, were measured, applying the International Prostate Symptom Score (IPSS), the 7-grade Quality of Life Scale (QoL) and medical status, the International Consultation on Incontinence Modular Questionnaire (ICIQ), the International Index of Erectile Function (IIEF-5) and the Common Terminology Criteria for Adverse Events (CTCAE v4.03). Seed migration and loss, dosimetric parameters and learning effects were also analyzed. Medium follow-up time was 50 months (range, 1–85 months). The five-year biochemical failure rate was 7%. Acute proctitis rates were 19% (grade 1) and 1% (grade 2), respectively. The overall incidence of incontinence was 19% (mild), 16% (moderate) and < 1% (severe). An increase in IPSS ≥ 5 points was detected in 59% of patients, with 38% regaining their baseline. Seed dislocation was found in 24% of patients and correlated with D90 and V100. A learning curve was found for seed migration, D90 and V100. QoL correlated with the general health condition of patient, incontinence symptoms and IPSS. BT for early stage prostate cancer offers excellent five-year biochemical control with low toxicities. QoL aspects are favorable. A learning curve was detected for procedural aspects but its impact on patient relevant endpoints remains inconclusive

  1. Quality Improvement in the National Cancer Institute Community Cancer Centers Program: The Quality Oncology Practice Initiative Experience

    Science.gov (United States)

    Siegel, Robert D.; Castro, Kathleen M.; Eisenstein, Jana; Stallings, Holley; Hegedus, Patricia D.; Bryant, Donna M.; Kadlubek, Pam J.; Clauser, Steven B.

    2015-01-01

    Purpose: The National Cancer Institute (NCI) Community Cancer Centers Program (NCCCP) began in 2007; it is a network of community-based hospitals funded by the NCI. Quality of care is an NCCCP priority, with participation in the American Society of Clinical Oncology Quality Oncology Practice Initiative (QOPI) playing a fundamental role in quality assessment and quality improvement (QI) projects. Using QOPI methodology, performance on quality measures was analyzed two times per year over a 3-year period to enhance our implementation of quality standards at NCCCP hospitals. Methods: A data-sharing agreement allowed individual-practice QOPI data to be electronically sent to the NCI. Aggregated data with the other NCCCP QOPI participants were presented to the network via Webinars. The NCCCP Quality of Care Subcommittee selected areas in which to focus subsequent QI efforts, and high-performing practices shared voluntarily their QI best practices with the network. Results: QOPI results were compiled semiannually between fall 2010 and fall 2013. The network concentrated on measures with a quality score of ≤ 0.75 and planned voluntary group-wide QI interventions. We identified 13 measures in which the NCCCP fell at or below the designated quality score in fall 2010. After implementing a variety of QI initiatives, the network registered improvements in all parameters except one (use of treatment summaries). Conclusion: Using the NCCCP as a paradigm, QOPI metrics provide a useful platform for group-wide measurement of quality performance. In addition, these measurements can be used to assess the effectiveness of QI initiatives. PMID:25538082

  2. FDG-PET scanning in patients with differentiated thyroid cancers. Institutional experience

    International Nuclear Information System (INIS)

    Full text: Patient with detectable serum thyroglobulin (Tg) and negative radioiodine whole body (RAI-WB) scan should have FDG-PET scan to locate tumor tissue. Sometimes scan fail to detect any pathologic accumulation of FDG. Some well-differentiated thyroid cancers do not accumulate FDG. In addition, tumor burden could be so small that imaging becomes impossible. To explore this possibility, several studies explored relationship between serum Tg level and result of FDG-PET scans. Results were inconclusive and it is not clear if there is some low level of serum Tg below which PET scanning is not cost effective. We examined all cases of thyroid cancer patients who underwent FDG-PET scanning in our institution (N-33) for relationship between Tg level and results of the scan. There were 16 females, 17 males. Age was 19-81 years. Follicular cancer was present in 2 patients while 31 had papillary cancer. 14 patients had PET scan while withdrawn from T4 therapy, and 19 patients were scanned while TSH was suppressed. Overall, 20 scans were considered positive, while 12 were negative. One patient was considered to have positive scan but after scan was repeated interpretation was changed into - positive uptake due to inflammation. In patients whose PET scan was positive, Tg level was in a range 6.6-7,108 ng/ml, while those with negative scan had Tg level in 1.7-36.5 ng/ml range. In group withdrawn from T4 therapy and positive scan Tg level ranged from 13.8-7,108 ng/ml, and with negative scan 2.8-36.5 ng/ml. In PET positive patients in euthyroid group Tg ranged 6.6-432 ng/ml and in negative 1.7-13.3 ng/ml. Conclusion: These results suggest that patients who have negative RAI scan and low Tg level may not benefit from PET scanning. In our study Tg level less than 6.6 ng/ml for the whole group, and below 13.8 ng/ml for patient withdrawn from T4 therapy did not result in positive FDG-PET scan result. Our group is small and more data need to be collected to clarify these

  3. Prevalence and Predictors of Neoadjuvant Therapy for Stage IIIA Non-Small Cell Lung Cancer in the National Cancer Database: Importance of Socioeconomic Status and Treating Institution

    International Nuclear Information System (INIS)

    Purpose: The optimal locoregional therapy for stage IIIA non-small cell lung cancer (NSCLC) is controversial, with definitive chemoradiation therapy (CRT) and neoadjuvant therapy followed by surgery (NT-S) serving as competing strategies. In this study, we used the National Cancer Database to determine the prevalence and predictors of NT in a large, modern cohort of patients. Methods and Materials: Patients with stage IIIA NSCLC treated with CRT or NT-S between 2003 and 2010 at programs accredited by the Commission on Cancer were included. Predictors were categorized as clinical, time/geographic, socioeconomic, and institutional. In accord with the National Cancer Database, institutions were classified as academic/research program and as comprehensive and noncomprehensive community cancer centers. Logistic regression and random effects multilevel logistic regression were performed for univariable and multivariable analyses, respectively. Results: The cohort consisted of 18,581 patients, 3,087 (16.6%) of whom underwent NT-S (10.6% induction CRT, 6% induction chemotherapy). The prevalence of NT-S was constant over time, but there were significant relative 31% and 30% decreases in pneumonectomy and right-sided pneumonectomy, respectively, over time (P trend <.02). In addition to younger age, lower T stage, and favorable comorbidity score, indicators of higher socioeconomic status were strong independent predictors of NT-S, including white race, higher income, and private/managed insurance. The type of institution (academic/research program vs comprehensive or noncomprehensive community cancer centers, odds ratio 1.54 and 2.08, respectively) strongly predicted NT-S, but treatment volume did not. Conclusions: Neoadjuvant therapy followed by surgery was an uncommon treatment approach in Commission on Cancer programs, and the prevalence of postinduction pneumonectomy decreased over time. Higher socioeconomic status and treatment at academic institutions were significant

  4. Arabic and English during Study Abroad in Cairo, Egypt: Issues of Access and Use

    Science.gov (United States)

    Trentman, Emma

    2013-01-01

    This article provides a snapshot of the experiences of 18 students studying abroad in Cairo, Egypt. Using a modified version of the language contact profile (Freed, Segalowitz, & Dewey, 2004), I investigate their language use and find that students use English more than they use Arabic and that there is considerable individual variation in…

  5. 78 FR 43852 - Correction for the Cairo, IL and Belmond, IA Areas

    Science.gov (United States)

    2013-07-22

    ... published on December 28, 2012 in FR Doc. 2012-76454, in the first column, the ``Areas Open for Designation..., Lake County, Tennessee. Correction In the Federal Register Notice published on December 28, 2012 in FR... Grain Inspection, Packers and Stockyards Administration Correction for the Cairo, IL and Belmond,...

  6. 76 FR 66932 - The National Cancer Institute (NCI) Announces the Initiation of a Public Private Industry...

    Science.gov (United States)

    2011-10-28

    ... Initiation of a Public Private Industry Partnership on Translation of Nanotechnology in Cancer (TONIC) To Promote Translational Research and Development Opportunities of Nanotechnology-Based Cancer Solutions... industry partnership called TONIC (Translation Of Nanotechnology In Cancer) to promote...

  7. Tumor induction following intraoperative radiotherapy: Late results of the National Cancer Institute canine trials

    Energy Technology Data Exchange (ETDEWEB)

    Barnes, M.; Duray, P.; DeLuca, A.; Anderson, W.; Sindelar, W.; Kinsella, T. (Fox Chase Cancer Center, Philadelphia, PA (USA))

    1990-09-01

    Intraoperative radiotherapy has been employed in human cancer research for over a decade. Since 1979, trials to assess the acute and late toxicity of IORT have been carried out at the National Cancer Institute in an adult dog model in an attempt to establish dose tolerance guidelines for a variety of organs. Of the 170 animals entered on 12 studies with a minimum follow-up of 2 years, 148 dogs received IORT; 22 control animals received only surgery. Animals were sacrificed at designated intervals following IORT, usually at 1, 6, 12, 24, and 60 month intervals. 102 of 148 irradiated dogs were sacrificed less than 24 months; 46 dogs were followed greater than or equal to 24 months after IORT. To date, 34 of the 46 animals have been sacrificed; the 12 remaining animals are to be followed to 5 years. These 12 animals have minimum follow-up of 30 months. In the irradiated group followed for greater than or equal to 24 months, 10 tumors have arisen in 9 animals. One animal developed an incidental spontaneous breast carcinoma outside the IORT port, discovered only at scheduled post-mortem exam. The remaining nine tumors arose within IORT ports. Two tumors were benign neural tumors--a neuroma and a neurofibroma. One animal had a collision tumor comprised of grade I chondrosarcoma adjacent to grade III osteosarcoma arising in lumbar vertebrae. Two other grade III osteosarcomas, one grade III fibrosarcoma, and one grade III malignant fibrous histiocytoma arose in retroperitoneal/paravertebral sites. An embryonal rhabdomyosarcoma (sarcoma botryoides) arose within the irradiated urinary bladder of one animal. No sham irradiated controls nor IORT animals sacrificed less than 24 months have developed any spontaneous or radiation-induced tumors. The time range of diagnoses of tumors was 24-58 months. The IORT dose range associated with tumor development was 20-35 Gy.

  8. Intensity modulated radiotherapy for locally advanced and metastatic pancreatic cancer: a mono-institutional retrospective analysis

    International Nuclear Information System (INIS)

    To evaluate the role of intensity modulated radiotherapy (IMRT) for locally advanced pancreatic cancer (LAPC) and metastatic pancreatic cancer (MPC), and the prognostic factors in the setting of multidisciplinary approach strategies. 63 patients with LAPC and MPC receiving IMRT in our institution were retrospectively identified. Information on patient baseline, treatment characteristics and overall survival (OS) time were collected. Data of pain relief and toxicity were evaluated. Univariate and multivariate analyses were conducted to investigate the prognostic factors. All patients received IMRT with a median dose of 46.0 Gy. The median OS for LAPC and MPC patients were 15.7 months and 8.0 months, respectively (p = 0.029). Symptomatic improvements were observed in the 44 patients with abdominal/back pain after radiotherapy (RT) or concurrent chemoradiotherapy (CCRT), particularly in those with severe pain. Only 13.9% and 14.8% cases presented Grade ≥ 3 hematologic toxicities in RT and CCRT group, while no cases developed Grade ≥ 3 non-hematologic toxicities in both groups. Multivariate analysis indicated that tumors located in pancreas body/tail (HR 0.28, p = 0.008), pretreatment CA19-9 < 1000 U/mL (HR 0.36, p = 0.029) and concurrent chemotherapy (HR 0.37, p = 0.016) were independent favorable predictors for OS. CCRT further improved OS for LAPC and MPC with acceptable toxicities, and use of RT markedly alleviated pain. Tumors located in pancreas body/tail, pretreatment CA19-9 level of < 1000 U/mL and CCRT were associated with better OS. However, regional intra-arterial chemotherapy did not show any survival benefit in our study

  9. CaIrO3: a Spin-Orbit Mott Insulator Beyond the jeff = 1/2 Ground State

    OpenAIRE

    Sala, M. Moretti; Ohgushi, K.; Al-Zein, A.; Hirata, Y; Monaco, G; Krisch, M.

    2014-01-01

    In CaIrO3 electronic correlation, spin-orbit coupling, and tetragonal crystal field splitting are predicted to be of comparable strength. However, the nature of its ground state is still object of debate, with contradictory experimental and theoretical results. We probe the ground state of CaIrO3 and assess the effective tetragonal crystal field splitting and spin-orbit coupling at play in this system by means of resonant inelastic x-ray scattering. We conclude that insulating CaIrO3 is not a...

  10. Multi-Institutional Analysis of Early Glottic Cancer from 2000 to 2005

    International Nuclear Information System (INIS)

    The purpose of this study is to analyze the outcome of patients with early glottic cancer (GC) treated with radiotherapy (RT) with or without chemotherapy at 10 institutions in the Tokai District, Japan. Ten institutions combined data from 279 patients with T1-T2 GC treated with RT with or without chemotherapy between 2000 and 2005. The overall survival rate, disease-specific survival rate, and local control rate were evaluated in 270 patients, except for incomplete cases due to issues such as discontinuation, using the method of Kaplan-Meier and compared using the log-rank test. Results were considered statistically significant at the level of p < 0.05. For 122 patients, the tumors were classified as T1a, while 64 patients had T1b tumors, and 84 patients had T2 tumors. In three cases of T1 tumors, the subtype was unknown. Combined chemoradiotherapy (CRT) was administered during each stage, and various chemotherapy drugs and regimens were used. The median follow-up period was 55.4 months. The 5-year LC rates for T1a, Tb, and T2 tumors in all patients were 87.9%, 82.7%, and 74.1%, respectively. The difference between T1a and T2 was statistically significant (p = 0.016). The 5-year LC rates for T1a, Tb, and T2 with CRT were 92.7%, 78.6%, and 80.7%, respectively, while the rates with radiation alone were 86.5%, 83.8%, and 64.4%, respectively. The difference between CRT and RT alone was not statistically significant in each stage. In this survey, CRT was performed for early GC at most institutions in clinical practice. Our data showed no statistical difference in the LC rates between CRT and RT alone in each stage. However, there was a tendency for the LCRs of the CRT group to be more favorable than those of the RT group in the T2-stage

  11. Multi-Institutional Analysis of Early Glottic Cancer from 2000 to 2005

    Directory of Open Access Journals (Sweden)

    Hirasawa Naoki

    2012-08-01

    Full Text Available Abstract Background The purpose of this study is to analyze the outcome of patients with early glottic cancer (GC treated with radiotherapy (RT with or without chemotherapy at 10 institutions in the Tokai District, Japan. Methods Ten institutions combined data from 279 patients with T1-T2 GC treated with RT with or without chemotherapy between 2000 and 2005. The overall survival rate, disease-specific survival rate, and local control rate were evaluated in 270 patients, except for incomplete cases due to issues such as discontinuation, using the method of Kaplan-Meier and compared using the log-rank test. Results were considered statistically significant at the level of p  0.05. Results For 122 patients, the tumors were classified as T1a, while 64 patients had T1b tumors, and 84 patients had T2 tumors. In three cases of T1 tumors, the subtype was unknown. Combined chemoradiotherapy (CRT was administered during each stage, and various chemotherapy drugs and regimens were used. The median follow-up period was 55.4 months. The 5-year LC rates for T1a, Tb, and T2 tumors in all patients were 87.9%, 82.7%, and 74.1%, respectively. The difference between T1a and T2 was statistically significant (p = 0.016. The 5-year LC rates for T1a, Tb, and T2 with CRT were 92.7%, 78.6%, and 80.7%, respectively, while the rates with radiation alone were 86.5%, 83.8%, and 64.4%, respectively. The difference between CRT and RT alone was not statistically significant in each stage. Conclusions In this survey, CRT was performed for early GC at most institutions in clinical practice. Our data showed no statistical difference in the LC rates between CRT and RT alone in each stage. However, there was a tendency for the LCRs of the CRT group to be more favorable than those of the RT group in the T2-stage.

  12. Clinicopathological Spectrum Of Gall Bladder Cancer In Kashmir - An Institutional Study.

    Science.gov (United States)

    Makhdoomi, R; Bashir, N; Bhat, N; Bashir, S; Mustafa, F; Aiman, A; Charaki, A; Hussain, S; Shafi, S; Baht, S; Bashir, N; Zahir, Z; Shah, P

    2016-01-01

    Gallbladder cancer is a highly aggressive malignancy that usually presents at an advanced incurable stage. It is the fifth most common gastro-intestinal tumor and leads to approximately 2800 deaths in United States annually. This was a retrospective study carried out in the Department of Pathology, Sher-i-Kashmir Institute of Medical Sciences, a 650-bed super speciality hospital in Kashmir valley. We reviewed the histopathological records of all the patients who were diagnosed as carcinoma gallbladder from Dec 2009-Dec 2013. Gross findings and histopathological findings were noted from the departmental archival material and clinical records of the patients including the clinical presentation, laboratory investigations, radiological investigations, pre-operative diagnosis and intra-operative findings, were retrieved from the hospital records. We analyzed 57 cases of carcinoma gallbladder for their clinicopathological features It included 19 males and 37 females. In our study, adenocarcinomas accounted for 87.5% of total carcinomas. Incidentally, all but one patient where gall stones were found, adenocarcinomas were seen. We have 4 patients of squamous cell carcinoma. In our series we have a single case of small cell carcinoma which was positive for neuroendocrine markers. In our study, gall stones were seen only in 8 cases (14%) of the total cases. PMID:27050183

  13. Physical properties of a linear accelerator-based stereotactic installed at national cancer institute

    International Nuclear Information System (INIS)

    The purpose of this paper is to present the dosimetry and mechanical accuracy of the first dedicated Siemens PRIMUS M6/6ST linear accelerator-based Stereotactic installed in National Cancer Institute for stereotactic radiosurgery and radiotherapy (SRS/SRT). The data were obtained during the installation, acceptance test procedure, and commissioning of the unit. The Primus M6/6ST has a single 6-MV beam with the same beam characteristics as that of the mother unit, the Siemens. The dosimetric data were taken using pin point ion chamber. The cone sizes vary from 12.5 to 40.0 mm diameter. The mechanical stability of the entire system was verified. The variations in isocenter position with table, gantry, and collimator rotation were found to be < 0.5 mm with a compounded accuracy of < or = 1.0 mm. The beam profiles of all cones in the x and y directions were within +/- 0.5 mm and match with the physical size of the cone. The basic dosimetry parameters such as tissue maximum ratio (TMR), off-axis ratio (OAR) and cone factor needed for patient treatment were evaluated. The mechanical and dosimetric characteristics including dose linearity of this unit are presented and found to be suitable for SRS/SRT. The difficulty in absolute dose measurement for small cone is discussed

  14. Treatment outcomes of female germ cell tumors: The Egyptian National Cancer Institute experience

    International Nuclear Information System (INIS)

    Introduction: Female germ cell tumors (GCTS) are rare tumors that carry a good prognosis. Aim: To report the experience of the Egyptian National Cancer Institute (ENCI) in managing female GCTs. Methods: This retrospective study included 19 females with ovarian GCTs presenting to the ENCI between 2006 and 2010. Results: The median age was 23 years. Ovaries were the primary site in all patients. Dysgerminoma and teratoma were the predominant pathologies followed by mixed GCT in females. Unilateral ovariectomy or ovarian tumorectomy were the classic surgical procedures with R0 resection being feasible in most cases. Surveillance was adopted in six patients with stage I disease. Chemotherapy was administered in 63% of ovarian GCTs with BEP being the commonest regimen with reasonable tolerability and good response rates. The median OS and EFS were not reached. The projected 5-year OS rate was 93.8%. Both OS and EFS were better in patients responding to chemotherapy than non-responders (p< 0.002). Stage of disease did not significantly affect OS or EFS. Conclusions: Female GCTs rarely affect Egyptian females. They have good prognosis.

  15. Evaluation of leakage in cobalt-60 unit in National Cancer Institute (NCI) Wad Medani

    International Nuclear Information System (INIS)

    This study has been conducted primarily to evaluate the leakages radiation in cobalt-60 unit in National Cancer Institute Wad Medani, which represent the basic risky factor in this unit for the radio therapists who spend much time during patient set up, also they need to stand near the head of the machine to fix some accessories. The measurements which done using survey meter give normal level of occupational exposure compared with IAEA references except one situation that the radio therapist to be close contact to the head of unit for long time which may increase the received dose, in this situation. The radio therapist either not well trained, or there is insufficient accessories to reduce the time inside the room. Radiotherapy department need a special considerations from the beginning of construction till starting of treatment. It is important to contain separate rooms, for planning to determine treatment area, another one for molding to shape lead blocks to protect normal parts and an optimum designed room for treatment to enable workers to apply basic radiation protection principles. (Author)

  16. The Gray Cancer Institute X-ray microprobe and its radiobiological applications

    International Nuclear Information System (INIS)

    Radiation micro-beams represent a unique and powerful tool to study and quantify the effects of precise doses of radiation delivered with micron precision to selected biological samples. The Gray Cancer Institute has developed two independent but complementary micro-irradiation facilities, specifically developed for the targeted irradiation of cells and structured tissues; a charged-particle microbeam that uses collimated protons or helium ions and an ultra-soft X-ray microprobe. The ultra-soft X-ray facility employs a focused electron bombardments source to produce a near monochromatic CK X-ray beam. Highly efficient zone plates optimised for the appropriate wavelength are used to focus the characteristic X-rays into a sub-micron spot. The facility is also equipped with a three-axis micro-positioning stage, an epi-fluorescent UV microscope with intensified CCD camera coupled to a fast PC for a automatic, fast and accurate samples recognition and alignment with the probe. Recent experiments have been directed to investigate the bystander effect by irradiating only one cell within a population of V79 cells that are subsequently individually revisited for colony formation. A clear bystander effect has been detected (∼ 10 % reduction in survival) when a single cell has been irradiated. The effect is triggered by very low doses ((∼ 100 mGy) and it is largely dose independent. (authors)

  17. Clinical and epidemiological profile of cases of deaths from stomach cancer in the National Cancer Institute, Brazil

    OpenAIRE

    Guedes, Maria Teresa dos Santos; de Jesus, José Paulo; de Souza Filho, Odilon; Fontenele, Raquel Malta; Sousa, Ana Inês

    2014-01-01

    Introduction Stomach cancer is the third most common cause of death worldwide, mainly affecting people with low socioeconomic status. In Brazil, we expect 20,390 new cases of stomach cancer in 2014, in both sexes, and according to the proportional distribution of the ten most prevalent types of cancer (except non-melanoma skin cancer) expected for 2014, this type of cancer was estimated to be the fourth most common in men and sixth in women. Aim To investigate and analyse the clinical and epi...

  18. DEMOGRAPHIC AND CLINICOPATHOLOGIC FEATURES OF PATIENTS WITH PRIMARY BREAST CANCER TREATED BETWEEN 1997 AND 2010: A SINGLE INSTITUTION EXPERIENCE.

    Science.gov (United States)

    Žitnjak, Daniela; Soldić, Željko; Kust, Davor; Bolanća, Ante; Kusić, Zvonko

    2015-09-01

    Breast cancer accounted for 28% of all new cancers and 18% of female cancer deaths in Europe in 2010. It is the most common type of cancer in women in Croatia, with an incidence rate of 56.9/100 000 in the year 2010, and the highest number of newly diagnosed women aged between 60 and 64. Multiple factors are associated with an increased risk of breast cancer: advancing age, family history, exposure to endogenous and exogenous reproductive hormones, dietary factors, benign breast disease, and environmental factors. To assess demographic and clinicopathologic features of primary breast cancer, we retrospectively analyzed 870 patients treated in our institution between 1997 and 2010. Data were obtained from medical documentation and a printed questionnaire regarding life habits. Most of our patients presented with a breast lump and were self-diagnosed by breast examination. This fact highlights the need of regular breast self-examination, although it should also be taken into account that most of our patients did not attend regular mammography screening (only 31%). One of the most concerning facts is that the mean time from observing the first symptom to visiting a physician was 4 months. Previous studies have identified ignorance, fear and fatalistic attitudes, poor socioeconomic conditions, and illiteracy as important factors resulting in delay. Considering these facts, education and raising awareness about the disease in the general population is one of the key weapons for lowering breast cancer mortality. PMID:26666098

  19. Results of treatment of differentiated thyroid cancers using Iodine-131 at Sri Lanka's first private institution

    International Nuclear Information System (INIS)

    Full text: This department was started in order to meet the urgent demand of iodine-131 treatment in differentiated thyroid cancer (DTC), as the waiting list in government hospitals was unduly long. Data obtained revealed that 52% of the patients had iodine-131 therapy within 4 months, 31% in 4 to 8 months and 17% over 8 months time. Institute received license to order, stock and administer iodine-131 from the AEA-Sri Lanka as its facilities were according to IAEA standards. Facility included three 'single bedded en-suit toilet rooms' with storage capacity for iodine-131 capsules. 115 cases (male: female ratio 1:4) of DTC were treated during the past one and half year and each received 100 GBq of radioactivity. 89 (77.3%) comprised papillary carcinoma, 25 (21.7%) follicular carcinoma and 1 case of mixed carcinoma. 52% of males and 60.8% of females were in the 26-45 years age group. Sixty cases of papillary carcinoma were sub-typed and grouped to observe the distribution of metastases and response to iodine-131. They were follicular variant (FV) in 28 (46%), micropaillary (MP) in 10 (20%), encapsulated (EP) in 8 (13.3%), tall cell (TC) in 3 (5%) and diffuse sclerosis (DS) in 9 (15%). TSH and Tg values were measured before therapy and four months afterwards. Activity readings were measured 30 min after ingestion and 4 days later and discharged when the values were less than 20 μSv / hour. Six of the nine (66%) DS cancer patients had metastasis in lymph nodes and lungs when referred for iodine-131 treatment. In 8 of these patients, Tg levels were raised. 36% (8/9) of the FC patients also had raised Tg levels indicating metastases and 4/5 were found to have bony metastases. In post iodine-131 therapy whole body scans, 3.3% had metastases in the lungs in PC and 20% of FC in skeleton. With a single dose of iodine-131 over 90% had drop in Tg levels to less than I ng/ml except in DS (23% drop) and TC (33% drop). The study shows that sub-typing of PC was useful and TC and

  20. Surgical treatment pattern and outcomes in epithelial ovarian cancer patients from a cancer institute in Kerala, India

    OpenAIRE

    Georgeena, P; Rajanbabu, Anupama; Vijaykumar, DK; Pavithran, K.; Sundaram, KR; Deepak, KS; Sanal, MR

    2016-01-01

    Objective To evaluate the treatment and survival pattern of patients with advanced epithelial ovarian cancer. Methods and results Retrospective study of all advanced epithelial ovarian cancer patients treated in the department of gynaecologic oncology from an academic centre, in a four year period from 1 January 2008–31 December 2011. Selection criteria All patients with advanced epithelial ovarian cancer (stage III and IV) who underwent surgery from 2008–2011and had a follow-up of at least t...

  1. Air pollution impact on aerosol variability over mega cities using remote sensing technology: case study, Cairo, Egypt

    International Nuclear Information System (INIS)

    Air pollution problems over mega cities differ greatly and are influenced by a number of factors, including topography, demography, meteorology, level and rate of industrialization and socioeconomic development. Cairo is considered a key city for economy, education, politics industry and technology in the Middle East.Increasing business and industrial activities in the city accompanied by shortage of the institutional capabilities for monitoring and control, in addition to environmental impact negligence that prevails over many of the production sectors, have contributed to excessive air pollution problems that have reached the level of crisis. A contributor to this problem is natural and man made effects such as dust and aerosols uptakes. Such pollution episodes are observed during the months of October showing the so called Black Cloud. Such pollution leads to wide variability of aerosols behavior over Cairo. Hence, aerosol related parameters obtained from satellite measurements have been studied here. Aerosol optical depth (AOD) behavior showed a dual maxima nature in each year from 2000 till 2005 during the months of (April, May) and October confirming dust and air pollution events, respectively. Such behavior is confirmed by the high negative correlation with the aerosol fine mode fraction (FMF) reaching -0.75. FMF product confirms a higher value during the months of October representing the Black Cloud episodes due to fine particles contribution in these events rather than during the dust events. However, lower values are observed in the last two years due to the new control measures enforced by the government for the environment protection. The difference between the AOD and FMF showed a higher contribution of the fine grains during the Black Cloud events rather than coarser grains during dust events as expected. Among the sources known to contribute to the black cloud formation is the fire burns over the Nile Delta region during the months of September and

  2. Nasolacrimal duct obstruction following radioactive iodine 131 therapy in differentiated thyroid cancers: review of 19 cases

    OpenAIRE

    Al-Qahtani KH; Al Asiri M; Tunio MA; Aljohani NJ; Bayoumi Y; Munir I; AlAyoubi A

    2014-01-01

    Khalid Hussain Al-Qahtani,1 Mushabbab Al Asiri,2 Mutahir A Tunio,2 Naji J Aljohani,3 Yasser Bayoumi,4 Iqbal Munir,5 Ayman AlAyoubi6 1Department of Otolaryngology – Head and Neck Surgery, College of Medicine, Advanced Head and Neck Oncology, King Saud University, 2Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, 3Endocrinology and Thyroid Oncology, King Fahad Medical City, Riyadh, Saudi Arabia; 4Radiation Oncology, NCI, Cairo University, Cairo, Egyp...

  3. Definitive Radiotherapy for T1-2 Hypopharyngeal Cancer: A Single-Institution Experience

    Energy Technology Data Exchange (ETDEWEB)

    Nakajima, Aya, E-mail: anakajima-kyt@umin.ac.jp [Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka (Japan); Nishiyama, Kinji; Morimoto, Masahiro; Nakamura, Satoaki; Suzuki, Osamu; Kawaguchi, Yoshifumi; Miyagi, Ken [Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka (Japan); Fujii, Takashi; Yoshino, Kunitoshi [Department of Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka (Japan)

    2012-02-01

    Purpose: To analyze the outcome in T1-2 hypopharyngeal cancer (HPC) patients treated with definitive radiotherapy (RT). Patients and Methods: A total of 103 patients with T1-2 hypopharyngeal squamous cell carcinoma treated with radical RT between March 2000 and June 2008 at our institution were analyzed. Pre-RT neck dissection (ND) was performed in 26 patients with advanced neck disease. Chemotherapy was used concurrently with RT in 14 patients. Sixty patients were associated with synchronous or metachronous malignancies. The median follow-up for surviving patients was 41 months. Results: The 3-year overall and cause-specific survival rates were 70% and 79%, respectively. The 3-year local control rates were 87% for T1 and 83% for T2 disease. The ultimate local control rate was 89%, including 7 patients in whom salvage was successful. The ultimate local control rate with laryngeal preservation was 82%. Tumors of the medial wall of the pyriform sinus tended to have lower control rates compared with tumors of the lateral or posterior pharyngeal wall. Among patients with N2b-3 disease, the 3-year regional control rates were 74% for patients with pre-RT ND and 40% for patients without ND. The 3-year locoregional control rates were as follows: Stage I, 100%; Stage II, 84%; Stage III, 67%; Stage IVA, 43%; Stage IVB, 67%. Forty-two patients developed disease recurrence, with 29 (70%) patients developing recurrence within the first year. Of the 103 patients, 6 developed late complications higher than or equal to Grade 3. Conclusions: Definitive RT accomplished a satisfactory local control rate and contributed to organ preservation.

  4. Cryotherapy for Primary Treatment of Prostate Cancer: Intermediate Term Results of a Prospective Study from a Single Institution

    OpenAIRE

    S. Alvarez Rodríguez; Arias Fúnez, F.; Bueno Bravo, C.; Rodríguez-Patrón Rodríguez, R.; Sanz Mayayo, E.; V. Hevia Palacios; Burgos Revilla, F. J.

    2014-01-01

    Purpose. Published data about cryotherapy for prostate cancer (PC) treatment are based on case series with a lack of clinical trials and the inexistence of a validated definition of biochemical failure. A prospective study with standardized followup protocol was conducted in our institution. Material and Methods. Prospective study of a series of cases including 108 patients diagnosed with localized PC at clinical stage T1c-T2c treated by primary cryoablation and median followup of 61 months. ...

  5. A pilot study to assess the level of depression and the coping strategies adopted by cancer patients receiving treatment in Mizoram State Cancer Institute, Aizawl

    Directory of Open Access Journals (Sweden)

    Gitumoni Konwar

    2015-01-01

    Full Text Available Background: Cancer, the second most common cause of death, has become a major health problem. Depression is the most common psychological problem encountered in patients with cancer. The coping skills adopted may affect the mental health of patients. Therefore, this research is undertaken to assess the level of depression and coping strategy adopted by the patients diagnosed with cancer. Materials and methods: A descriptive study to assess the level of depression and coping strategy adopted by cancer patients receiving treatment in Mizoram State Cancer Institute, Aizawl was carried out from April to May 2014 with 30 convenient samples. Depression was assessed by using Hospital Anxiety and Depression Scale (HADS developed by Zigmond and Snaith in 1983. Coping strategy adopted by patients were assessed by revised version of the Ways of Coping Checklist developed by Folkman and Lazarus in 1985. Results: Findings of the study showed that depression was universal to all the cancer patients. Majority of cancer patients (66.5% had moderate depression while 13.26% of the cancer patients had severe depression, and only 6.7% of them reported to have low depression. The most effective coping strategy adopted was reappraisal, followed by distancing. There is significant correlation between depression and reappraisal (r=-0.538, p<0.002, and also with depression and acceptance (r=-0.415, p<0.022 strategies. Conclusion: As depression is universal to all cancer patients, use of appropriate coping strategy is very essential to improve their quality of life. The recognition of coping strategies by health team may enable appropriate information and interventions to be provided at optimal times for each individual.

  6. First-principles study of the electronic structure and magnetism of CaIrO3

    Science.gov (United States)

    Subedi, Alaska

    2012-01-01

    I study the electronic structure and magnetism of postperovskite CaIrO3 using first-principles calculations. The density functional calculations within the local density approximation without the combined effect of spin-orbit coupling and on-site Coulomb repulsion show the system to be metallic, which is in disagreement with the recent experimental evidences that show CaIrO3 to be an antiferromagnetic Mott insulator in the Jeff=1/2 state. However, when spin-orbit coupling is taken into account, the Ir t2g bands split into fully filled Jeff=3/2 bands and half-filled Jeff=1/2 bands. I find that spin-orbit coupling along with a modest on-site Coulomb repulsion opens a gap leading to a Mott insulating state. The ordering is antiferromagnetic along the c axis with total moments aligned antiparallel along the c axis and canted along the b axis.

  7. Deuterium, oxygen-18 and salt content of drinking water sources in Cairo

    International Nuclear Information System (INIS)

    The continuous increase of population in Cairo exceeding 10 millions inhabitants lead to the search for supplementary potable water resources in addition to the Nile River which is the principle drinking water source. Groundwater represents the main supplementary source. Evaluation of the groundwater feeding the so-called El-Ameria Water Treatment Station which is one of the biggest potable water supplies at the northern of Cairo was carried out. Chemical and isotopic techniques were applied to estimate the suitability of this groundwater for drinking purposes. The chemical analysis includes the determination of sodium, potasium, calcium and magnesium concentrations in additon to those of chlorides, sulphates, bicarbonates and silicates, while the isotopic analysis includes oxygen-18 and deuterium. The overall chemical- and isotopic investigations determined the conditions at which the examined groundwater is suitable for drinking purposes. (orig.)

  8. Analytical Characterization of Rococo Paintings in Egypt: Preliminary Results from El-Gawhara Palace at Cairo

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    Fatma REFAAT

    2012-12-01

    Full Text Available El-Gawhara palace (1813–1814 AD is situated south of the Mosque of Muhammad Ali in the Cairo Citadel. This palace is an important example of the best early 19th century rococo decorations in Egypt. The present study reports some of the results obtained from the application of different analytical techniques to characterize some rococo paintings at El-Gawhara palace at Cairo, Egypt. The characterization of the studied paintings was carried out by means of optical microscopy (OM, scanning electron microscopy equipped with an energy dispersive X-ray detector (EDS and Fourier transform infrared spectroscopy (FT−IR. The obtained results allowed the identification of the chemical composition, structure and the painting technique employed in these paintings. This methodology reveals some useful information on some rococo paintings dating back to the 19th century in Egypt.

  9. Reduction of lead pollution from vehicular emissions in cairo Part 1: Comparison of alternative solutions

    International Nuclear Information System (INIS)

    It has been recognized for decades that the major source of lead pollution is lead additives to automotive fuels. This problem has been countered in most countries in europe and Usa by introducing alternative anti-knock chemicals and unleaded gasoline. In egypt lead is still being added to gasoline in large quantities. However, progress has been made, and unleaded gasoline is currently being produced in Alexandria. Nevertheless, the major pollution problem remains in the Greater Cairo region as indicated by the atmospheric lead levels and the lead blood levels of the children in Cairo. The aim of the present study is to find an optimum solution to this problem. A comparison of the different solutions is conducted in order to come up with the most feasible solution to this urgent problem. In conclusion it has been demonstrated that the elimination of lead additives, with its huge positives effects on the country environment, proved to be profitable. 4 figs., 2 tabs

  10. Cairo city air quality research initiative part-i: A meteorological modelling

    International Nuclear Information System (INIS)

    The modified meteorological model Hotmac (Higher order turbulence model for atmospheric circulation) is a three-dimensional and finite grid model developed primarily for simospheric motions and based on solving the conservation equations of mass momentum, energy and turbulent kinetic energy. The model is used for studying air quality of cairo cty and its surrounding to treat a domain that includes an urbanized area for understanding problems of air pollution. The acquired terrain (elevation) data for Egypt was obtained. The local and upper level geostrophic data were provided by rawinsonde of wind speed and direction, temperature,relative humidity, water vapour, and pressure The potential temperature was obtained by a computer program. The meteorological data was obtained for helwan site, about 20 kilometer south of cairo city. Three mested grids were used, with grids resolutions of 2 6 and 18 kilometers to cover a domain of approximately 360 km that extended from the red Sea to the mediterranean Sea

  11. Learning from Cairo. Global Perspectives and Future Visions de Beth Stryker, Omar Nagati et Magda Mostafa

    OpenAIRE

    Stadnicki, Roman

    2013-01-01

    Faisant référence au succès éditorial mondial de D. Scott Brown et R. Venturi sur Las Vegas, lequel marqua la naissance du postmodernisme en architecture, Learning from Cairo apparaît comme un ouvrage tout aussi innovant, qui devrait marquer les études urbaines sur l’Égypte, le Moyen-Orient et plus largement les pays du Sud et qui, lui non plus, ne devrait pas échapper à la controverse. Précisons tout de suite que l’intérêt de Learning from Cairo réside moins dans son contenu à proprement par...

  12. Transformational Weakening During the Perovskite-Post Perovskite Phase Transition in CaIrO3

    Science.gov (United States)

    Hunt, S. A.; Dobson, D. P.; Weidner, D. J.; Li, L.; Vaughan, M. T.; Walte, N.; Brodholt, J. P.

    2007-12-01

    The D" layer plays a fundamental role in core - mantle interactions. The recent discovery of a CaIrO3 structured phase of MgSiO3, the so called post-perovskite (ppv) phase, significantly altered our understanding of the seismic and dynamic properties of the D". Here we report results of a study of the rheology during transformation from pv to pvv. The experiments were performed using the D-DIA on the X17B2 beamline at NSLS. A sample of presintered perovskite structured CaIrO3 was deformed, along with a MgO stress calibrant, during heating at 3 GPa and up to 1000°C in a 8mm D-DIA assembly. The stress was measured by X-ray diffraction from the MgO sample and a proxy for the phase proportions was the relative strengths of unique perovskite and post-perovskite diffraction peaks from the CaIrO3 sample. The strain was measured by X-radiography, from the position of Platinum foils placed above, between and below the two samples. From this data the viscosity of the CaIrO3 sample can be calculated as well as the progress of the reaction. During the transformation to post-perovskite we observed a two fold weakening of the pv and ppv mixture; followed by an increase in the strength of the mixture to greater than that of that starting perovskite-structured material. If MgSiO3 behaves in the same way during pv - ppv transformation it will cause a viscous decoupling between the lower mantle and the D". This in turn has major implications for the topography that can be supported at the top of the D" layer.

  13. Persistent semi-metal-like nature of epitaxial perovskite CaIrO3 thin films

    OpenAIRE

    Biswas, Abhijit; Jeong, Yoon Hee

    2015-01-01

    Strong spin-orbit coupled 5d transition metal based ABO3 oxides, especially iridates, allow tuning parameters in the phase diagram and may demonstrate important functionalities, for example, by means of strain effects and symmetry-breaking, because of the interplay between the Coulomb interactions and strong spin-orbit coupling. Here, we have epitaxially stabilized high quality thin films of perovskite (Pv) CaIrO3. Film on the best lattice-matched substrate shows semi-metal-like characteristi...

  14. 开罗夜未眠%SLEEPLESS iN CaiRo

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ During the last few years,my neighborhood in Cairo has experienced such an influx of refugees from the Iraq war that longtime residents have begun,with a mixture of affection and unease,to call it New Baghdad.Two dialects of Arabic are spoken in the streets,and there is Iraqi flatbread for sale in the local market.The family living in the apartment upstairs came to Egypt from Iraq nine months ago.

  15. Exclusion and Informality: The Praetorian Politics of Land Management in Cairo, Egypt

    OpenAIRE

    Dorman, W. J.

    2013-01-01

    Since the late 1970s, Western aid agencies, including the US Agency for International Development (AID) and the World Bank, sought to assist the Egyptian government in planning its capital, Cairo. The aim was to foster an administratively competent Egyptian state able to respond, for example, to informal urbanization of the city's agricultural periphery by channelling the city's growth into planned and serviced desert sites. However, these initiatives were almost entirely unsuccessful. Egypti...

  16. Alberto Cairo: The Functional Art. An introduction to information graphics and visualization, Berkeley 2012

    OpenAIRE

    Osińska, Veslava

    2015-01-01

    Review of the first book to offer a broad, hands-on introduction to information graphics and visualization, the use of charts, maps, diagrams, and illustrations to communicate and understand data and phenomena. Alberto Cairo, who teaches at the University of Miami, explains that visualizations should be conceived as tools that extend human perception, letting go beyond what the bare eye can see, and allow to identify patterns and trends that would be invisible otherwise. Recenzja pierwszej...

  17. Difficult airway management patterns among anesthesiologists practicing in Cairo University Hospitals

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    Neamat I. Abdel rahman

    2016-01-01

    Conclusion: The practice of anesthesiologists in Cairo university hospitals is close to the recommendations of the ASA guidelines for management of difficult airway. There is increased skills in fiberoptic bronchoscopes and SGA with increased frequency of difficult airway managements training courses; however, they need to improve their skills in awake fiberoptic intubations technique and they need to be trained on invasive airway management access to close the discrepancy between their theoretical choices in different situations and their actual skills.

  18. Screening mammography. A missed clinical opportunity? Results of the NCI [National Cancer Institute] Breast Cancer Screening Consortium and national health interview survey studies

    International Nuclear Information System (INIS)

    Data from seven studies sponsored by the National Cancer Institute (NCI) were used to determine current rates of breast cancer screening and to identify the characteristics of and reasons for women not being screened. All seven studies were population-based surveys of women aged 50 to 74 years without breast cancer. While over 90% of non-Hispanic white respondents had regular sources of medical care, 46% to 76% had a clinical breast examination within the previous year, and only 25% to 41% had a mammogram. Less educated and poorer women had fewer mammograms. The two most common reasons women gave for never having had a mammogram were that they did not known they needed it and that their physician had not recommended it. Many physicians may have overlooked the opportunity to recommend mammography for older women when performing a clinical breast examination and to educate their patients about the benefit of screening mammography

  19. Comparison of Serum Selenium Levels in Breast Cancer Patients and Healthy People at a Cancer Institute in 2004

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    M Maleki

    2007-01-01

    Full Text Available Introduction: Breast Cancer is one of the most important fatal cancers in women. The mean age of breast cancer in Iran is 48.8 years which is very lower than other countries. Selenium can play an important role in reduction of cancer in several ways, for example selenium increases immunity response and protects cells from oxidation of free radicals and also decreases carcinogenic metabolites. Breast cancer is one of the most important cancers in our country because its incidence is very high and the mean age of patients is very low. Different studies have shown the benefits of selenium in prevention of cancer and since many years selenium has been used as a dietary supplement in advanced countries. Several studies regarding relationship between selenium levels and breast cancer have been done in different countries. We therefore planned a study to evaluate serum selenium levels in breast cancer patients and compare them with a healthy control group. Methods: We selected 45 patients younger than 48 years old and 33 patients older than 48 years old who had not yet received any therapy (surgery, chemotherapy, etc for their cancer as a case group and 46 healthy people who were matched with the patients as a control group and included 23 persons younger and 23 persons older than 48 years old. From each participant, 5cc blood was derived and in several stages, serum selenium levels were evaluated using atomic absorption technology. Data about type of cancer, stage, grade, IHC and cigarette smoking were also collected. Results: The mean Se level was 161.20 μg/l (SD=46.27 μg/l in the patients and 189.13 μg/l (SD=48.75 μg/l in the control group that was statistically significant (P48 years old was 155.39 μg/l (SD=46.68 μg/l that was lower than the control groups. Difference in serum selenium levels between patients and controls in the older group was significant (P=0.007, but in the younger group, it was not statistically significant (P=0

  20. Improving the marketing abilities of some egyptian exports using radiation technology in cairo air port

    International Nuclear Information System (INIS)

    The economics of establishing a food irradiation facility at cairo airport are discussed together with the effect of various parameters on uint processing costs. This study comprises the determination of the commodity mix for the egyptian food commodities that are proposed for irradiation and export from the cairo airport. The commodity mix is distributed for the full utilization of the working capacity and the evaluation of the type of the irradiation facility and also the radiation source strength. The financial analysis for such an irradiation facility is also carried out. It provides a model for calculating specific unit processing costs by correlating known capital costs with annual operation cost and annual throughputs. We analyzed the cost- benefit of the proposed food irradiation facility. We took into account the cost of the capital investment, operation and other additional parameters and then estimated the unit cost. The investment criteria utilized for commercial evaluation were internal rate of return (I.I.R.) and pay back period (P.B.P.). The irradiation cost and the additional income are also discussed. The results of this analysis showed that the installation of the an irradiation unit for the establishment of food irradiation unit in cairo air port in would be economically feasible

  1. Development and validation of a lead emission inventory for the Greater Cairo area

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    Zeinab Safar

    2014-09-01

    Full Text Available Studies that investigate the environmental health risks to Cairo residents invariably conclude that lead is one of the area’s major health hazards. The Cairo Air Improvement Project (CAIP, which was implemented by a team led by Chemonics International, funded by USAID in partnership with the Egyptian Environmental Affairs Agency (EEAA, started developing a lead emission inventory for the greater Cairo (GC area in 1998. The inventory contains a list by major source of the annual lead emissions in the GC area. Uses of the inventory and associated database include developing effective regulatory and control strategies, assessing emissions trends, and conducting modeling exercises. This paper describes the development of the current lead emissions inventory (1999–2010, along with an approach to develop site specific emission factors and measurements to validate the inventory. This paper discusses the major sources of lead in the GC area, which include lead smelters, Mazout (heavy fuel oil combustion, lead manufacturing batteries factories, copper foundries, and cement factories. Included will be the trend in the lead emissions inventory with regard to the production capacity of each source category. In addition, the lead ambient measurements from 1999 through 2010 are described and compared with the results of Source Attribution Studies (SAS conducted in 1999, 2002, and 2010. Due to EEAA/CAIP efforts, a remarkable decrease in more than 90% in lead emissions was attained for 2007.

  2. Retrospective assessment of occupational asbestos exposure among 220 patients with respiratory cancer hospitalized at Vilnius University Institute of Oncology

    International Nuclear Information System (INIS)

    No cases of lung cancer or mesothelioma have ever been diagnosed or compensated as asbestos-related in Lithuania. This paper attempts to estimate the proportion of those occupationally exposed to asbestos among respiratory cancer patients. Occupational exposure to asbestos was assessed retrospectively for 218 lung cancer and 2 mesothelioma patients admitted to Institute of Oncology, Vilnius University. The evaluation was based on personal interview data using an internationally established questionnaire. Cumulative exposure to asbestos at work was evaluated in fibre-years. A cumulative asbestos exposure of ≥25 fibre-years was found for 7 patients (3.2%), in further 135 (61.2%) a cumulative exposure from 0.01 to 24.99 fibre-years was assessed. The most common occupations among heavily (≥25 fibre-years) exposed patients were smith, welder or insulator in foundries, construction, shipyard as well as asbestos cement and glass industry. Preliminary findings indicate that a fraction (3.2%) of the respiratory cancer cases could be attributed to occupational exposure to asbestos. Since 1560 or more cases of lung cancer are registered every year in Lithuania, about 50 cases per year could be predicted to be asbestos-related. (author)

  3. Epidemiology and management of breast carcinoma in Egyptian males: Experience of a single Cancer Institute

    International Nuclear Information System (INIS)

    To assess the epidemiological and clinico-pathological features, surgical and reconstructive techniques, adjuvant treatments and clinical outcome of breast carcinoma in males (BCM) at the Egyptian National Cancer Institute (NCI). Patients and methods: Thirty-two males with breast carcinoma presented to NCI between January 2000 and December 2002. They were evaluated by complete history, physical examination, laboratory and radiological investigations. Results: Median age was 59 years. Left sided and retroareolar breast lumps were the commonest presentations. Grade 11 tumors positive for hormone receptors were very common. Stage I, II, 111 and IV disease were encountered in 6.2%, 34.4%, 34.4% and 25.0% of patients, respectively. Curative surgery was done in 22 patients; they received adjuvant hormonal therapy, chemotherapy and radiotherapy in 22,16 and 10 patients, respectively. Eight metastatic patients were treated with palliative measures. Surgery was done in 25 patients; the most common procedure was modified radical mastectomy (40.6%). Primary closure was feasible in 17 patients (68%), local flaps were needed in 4 cases (16%), while myocutaneous flap was done in 3 cases (12%). The commonest complication was development of seroma (9 cases). The overall survival (OS) at 5 years was 65.4%. The disease free survival (DPS) at 5 years was 53.9%. Stage and curative surgery significantly affected OS, while type of surgery was the only variable significantly affecting DPS. Conclusion: Male breast carcinoma occurs at older ages than females, usually in advanced stage. This necessitates directing attention of males and awareness on the prevalence and risk factors for this disease.needed in 4 cases (16%), while myocutaneous flap was done in 3 cases (12%). The commonest complication was development of seroma (9 cases). The overall survival (OS) at 5 years was 65.4%. The disease free survival (DPS) at 5 years was 53.9%. Stage and curative surgery significantly affected OS

  4. Clinical features of esophageal cancer in the octogenarian treated by definitive radiotherapy. A multi-institutional retrospective survey

    International Nuclear Information System (INIS)

    As age-related infirmity often influences treatment options and outcome of esophageal cancer, the optimization of treatment for the elderly, especially in octogenarians, has been the subject of considerable debate. We performed a retrospective, multi-institutional survey to assess the effect of age on the outcome of definitive radiotherapy for esophageal cancer by a questionnaire sent to eight institutions in Japan. There were 362 evaluable replies. The patients included 317 males and 45 females, with a median age of 72 years (range 35-93 years), and 96% had squamous cell carcinoma. There were 30 clinical stage I, 71 stage IIA, 17 stage IIB, 113 stage III and 116 stage IV cases. The stage was not specified in 16 cases. Multiple co-morbidities existed in 40% of the patients who were 70 years of age or older. There was no statistically significant age-related difference in the incidence of adverse reactions to radiotherapy (p>0.05). Overall survival was more significantly affected by Karnofsky Performance Status than by the patient's age. The influence of performance status on cumulative survival for stage I and II disease was more pronounced in patients in their 80s. The safety of radiotherapy for esophageal carcinoma is not influenced by the patient's age. Because the performance status strongly influenced survival, the multi-disciplinary assessment of functional status is mandatory for optimizing the choice of treatment for patients in their 80s with esophageal cancer. (author)

  5. Characterization of CTX-M ESBLs in Enterobacter cloacae, Escherichia coli and Klebsiella pneumoniae clinical isolates from Cairo, Egypt

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    Khalaf Noha G

    2009-06-01

    Full Text Available Abstract Background A high rate of resistance to 3rd generation cephalosporins among Enterobacteriaceae isolates from Egypt has been previously reported. This study aims to characterize the resistance mechanism (s to extended spectrum cephalosporins among resistant clinical isolates at a medical institute in Cairo, Egypt. Methods Nonconsecutive Klebsiella pneumoniae (Kp, Enterobacter cloacae (ENT and Escherichia coli (EC isolates were obtained from the clinical laboratory at the medical institute. Antibiotic susceptibility was tested by CLSI disk diffusion and ESBL confirmatory tests. MICs were determined using broth microdilution. Isoelectric focusing (IEF was used to determine the pI values, inhibitor profiles, and cefotaxime (CTX hydrolysis by the β-lactamases. PCR and sequencing were performed using blaCTX-M and ISEcp1-specific primers, with DNA obtained from the clinical isolates. Conjugation experiments were done to determine the mobility of blaCTX-M. Results All five clinical isolates were resistant to CTX, and were positive for ESBL screening. IEF revealed multiple β-lactamases produced by each isolate, including a β-lactamase with a pI of 8.0 in Kp and ENT and a β-lactamase with a pI of 9.0 in EC. Both β-lactamases were inhibited by clavulanic acid and hydrolyzed CTX. PCR and sequence analysis identified blaCTX-M-14 in Kp and ENT and a blaCTX-M-15 in EC. Both blaCTX-M-14 and blaCTX-M-15 were preceded by ISEcp1 elements as revealed by partial sequence analysis of the upstream region of the blaCTX-M genes. blaCTX-M-15 was transferable but not blaCTX-M-14. Conclusion This is the first report of CTX-M-14 in Kp and ENT isolates from Egypt, the Middle East and North Africa.

  6. Nonsteroidal anti-inflammatory drugs and breast cancer risk in the National Institutes of Health–AARP Diet and Health Study

    OpenAIRE

    Gierach, Gretchen L.; James V Lacey; Schatzkin, Arthur; Leitzmann, Michael F.; Richesson, Douglas; Hollenbeck, Albert R.; Brinton, Louise A.

    2008-01-01

    Introduction By inhibiting cyclooxygenase-2, nonsteroidal anti-inflammatory drugs (NSAIDs) decrease aromatase activity and might reduce breast cancer risk by suppressing estrogen synthesis. Epidemiologic evidence for a protective role of NSAIDs in breast cancer, however, is equivocal. Methods We tested NSAID use for its association with breast cancer incidence in the National Institutes of Health–AARP Diet and Health Study, where 127,383 female AARP (formerly known as the American Association...

  7. Effective Utilization of Arbitrators and Arbitration Institutions in Africa by Appointors

    OpenAIRE

    Onyema, Emilia

    2008-01-01

    This paper delivered at an international conference on arbitration and Africa in Cairo examines how arbitrators of African origin and arbitration institutions in Africa can be better utilized by those who appoint them in arbitration especially where one party in the dispute is African.

  8. Patient-centered cancer treatment planning: improving the quality of oncology care. Summary of an Institute of Medicine workshop.

    Science.gov (United States)

    Balogh, Erin P; Ganz, Patricia A; Murphy, Sharon B; Nass, Sharyl J; Ferrell, Betty R; Stovall, Ellen

    2011-01-01

    The Institute of Medicine's National Cancer Policy Forum recently convened a workshop on patient-centered cancer treatment planning, with the aim of raising awareness about this important but often overlooked aspect of cancer treatment. A primary goal of patient-centered treatment planning is to engage patients and their families in meaningful, thorough interactions with their health care providers to develop an accurate, well-conceived treatment plan, using all available medical information appropriately while also considering the medical, social, and cultural needs and desires of the patient and family. A cancer treatment plan can be shared among the patient, family, and care team in order to facilitate care coordination and provide a roadmap to help patients navigate the path of cancer treatment. There are numerous obstacles to achieving patient-centered cancer treatment planning in practice. Some of these challenges stem from the patient and include patients' lack of assertiveness, health literacy, and numeracy, and their emotional state and concurrent illnesses. Others are a result of physician limitations, such as a lack of time to explain complex information and a lack of tools to facilitate treatment planning, as well as insensitivity to patients' informational, cultural, and emotional needs. Potential solutions to address these obstacles include better training of health care providers and patients in optimal communication and shared decision making, and greater use of support services and tools such as patient navigation and electronic health records. Other options include greater use of quality metrics and reimbursement for the time it takes to develop, discuss, and document a treatment plan. PMID:22128118

  9. Determinants of quality of life in prostate cancer patients: A single institute analysis

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    Yao-Lin Kao

    2015-12-01

    Conclusion: Our data demonstrated that marital status is an important determinant of quality of life in prostate cancer patients besides other sociodemographic factors. Clinicians are advised to provide more social support recourses for patients who do not have a partner.

  10. Determinants of quality of life in prostate cancer patients: A single institute analysis

    OpenAIRE

    Yao-Lin Kao; Yuh-Shyan Tsai; Fat-Ya Ou; Ya-Jhu Syu; Chien-Hui Ou; Wen-Horng Yang; Hong-Lin Cheng; Tzong-Shin Tzai; Jung-Der Wang

    2015-01-01

    Objective: To determine factors that influence quality of life in prostate cancer patients. Patients and methods: Patients with pathologically verified prostate cancer and treated at the National Cheng Kung University Hospital were invited to fill out the World Health Organization Quality of Life-BREF questionnaires at the outpatient clinic. We explored the determinants of quality of life including age, education, income, marital status, disease stage, and treatment modality using a mixed-...

  11. Cryotherapy for primary treatment of prostate cancer: intermediate term results of a prospective study from a single institution.

    Science.gov (United States)

    Rodríguez, S Alvarez; Arias Fúnez, F; Bueno Bravo, C; Rodríguez-Patrón Rodríguez, R; Sanz Mayayo, E; Palacios, V Hevia; Burgos Revilla, F J

    2014-01-01

    Purpose. Published data about cryotherapy for prostate cancer (PC) treatment are based on case series with a lack of clinical trials and the inexistence of a validated definition of biochemical failure. A prospective study with standardized followup protocol was conducted in our institution. Material and Methods. Prospective study of a series of cases including 108 patients diagnosed with localized PC at clinical stage T1c-T2c treated by primary cryoablation and median followup of 61 months. Criteria of biochemical recurrence were unified according to the American Society for Therapeutic Radiology and Oncology (ASTRO). End points were biochemical progression-free survival (BPFS), cancer-specific survival, and overall survival. Rate of complications was reported. Results. The BPFS for low-, medium-, and high-risk patients was 96.4%, 91.2%, and 62.2%, respectively. Cancer-specific survival was 98.1%. Overall survival reached 94.4%. Complications included incontinence in 5.6%, urinary tract obstruction in 1.9%, urethral sloughing in 5.6%, haematuria in 1.9%, perineal pain in 11.1%, and prostatorectal fistula in 0.9%. Erectile disfunction was found in 98.1%. Conclusions. Cryotherapy is an effective and minimally invasive treatment for primary PC in well-selected cases, with low surgical risk and good results in terms of BPFS, cancer-specific survival, and overall survival. PMID:24693437

  12. The perovskite to post-perovskite transition in CaIrO3

    Science.gov (United States)

    Tronnes, R. G.; Frost, D. J.; Boffa-Ballaran, T.; Stolen, S.

    2006-12-01

    The phase transition of MgSiO3-dominated perovskite to a post-perovskite phase with CaIrO3-type structure in the deep mantle has important implications for the core-mantle boundary heat flux and Earth's dynamics. The Clapeyron slope of the phase boundary is a critical parameter in geodynamical models but cannot be determined accurately in laser-heated diamond anvil experiments. Experiments using suitable analogue compositions where the perovskite to post-perovskite transition (PvPPpvT) can be studied within the pressure ranges of the piston cylinder or multianvil apparatus may therefore be useful. Hirose and Fujita [1] investigated the PvPPvT in CaIrO3 at 1-3 GPa and 1350-1550 ºC, and found a dp/dT-slope of 14-20 MPa/K. We investigated the transition, using narrower brackets and a few reversal experiments and located the transition at the somewhat higher temperatures of 1458-1513 at 1-2.5 GPa, with dp/dT-slope of 26-29 MPa/K. In addition to the reversal experiments, using Pv and PPv, we also investigated the potential effect of different starting materials including CaO + IrO2 oxide mixes and oxide mixes reacted at 850-900 C. The starting material issue is especially important for CaIrO3, because CaO is hygroscopic and because minor amounts of reduced Ir starts to form even in air at temperatures above about 800 C. Special care was taken to minimize these effects. The Clapeyron slopes determined for the PvPPvT in the CaIrO3-system are considerably larger that those estimated for MgSiO3 from first principles and ab-initio models and from modelling of the topography of the upper and lower D"-discontinuities, assuming that these discontinuities are caused by the PvPPvT. Clapeyron slopes ranging from 6 to 10 MPa/K have been used in such geodynamic modelling. In order to characterize the PvPPvT in CaIrO3 further, we will derive crystallographic, elastic and thermodynamic parameters for the perovskite and post-perovskite phases by single-crystal XRD, combined with

  13. CaIrO3: A Spin-Orbit Mott Insulator Beyond the jeff=1/2 Ground State

    Science.gov (United States)

    Sala, M. Moretti; Ohgushi, K.; Al-Zein, A.; Hirata, Y.; Monaco, G.; Krisch, M.

    2014-05-01

    In CaIrO3, electronic correlation, spin-orbit coupling, and tetragonal crystal field splitting are predicted to be of comparable strength. However, the nature of its ground state is still an object of debate, with contradictory experimental and theoretical results. We probe the ground state of CaIrO3 and assess the effective tetragonal crystal field splitting and spin-orbit coupling at play in this system by means of resonant inelastic x-ray scattering. We conclude that insulating CaIrO3 is not a jeff=1/2 iridate and discuss the consequences of our finding to the interpretation of previous experiments. In particular, we clarify how the Mott insulating state in iridates can be readily extended beyond the jeff=1/2 ground state.

  14. CaIrO3: a spin-orbit Mott insulator beyond the j(eff) ground state.

    Science.gov (United States)

    Sala, M Moretti; Ohgushi, K; Al-Zein, A; Hirata, Y; Monaco, G; Krisch, M

    2014-05-01

    In CaIrO3, electronic correlation, spin-orbit coupling, and tetragonal crystal field splitting are predicted to be of comparable strength. However, the nature of its ground state is still an object of debate, with contradictory experimental and theoretical results. We probe the ground state of CaIrO3 and assess the effective tetragonal crystal field splitting and spin-orbit coupling at play in this system by means of resonant inelastic x-ray scattering. We conclude that insulating CaIrO3 is not a j(eff) = 1/2 iridate and discuss the consequences of our finding to the interpretation of previous experiments. In particular, we clarify how the Mott insulating state in iridates can be readily extended beyond the j(eff) = 1/2 ground state. PMID:24836260

  15. A study of ultraviolet solar radiation at Cairo urban area, Egypt

    Energy Technology Data Exchange (ETDEWEB)

    Robaa, S.M. [Cairo Univ., Giza (Egypt). Dept. of Astronomy and Meterology

    2004-07-01

    The monthly mean values of global, G, and ultraviolet, UV, solar radiation incident on a horizontal surface at Cairo urban area during the two different periods (1969-1973) and (1993-1997) are presented, analyzed and compared. The effect of urbanization processes on the solar radiation components is investigated and discussed. It was found that the total radiation of the two components, G and UV received at the urban area of Cairo during the period (1969-1973) highly exceeds the radiation received during the period (1993-1997) for all months of the year. The mean relative reduction of G and UV reached 17.4% and 27.4% respectively. A significant correlation between G and UV radiation has been established and the recommended correlation equation has been stated to estimate the values of UV radiation that are difficult to measure at any site in the zone of Lower Egypt. Also, a comparative study of the two radiation components, G and UV, at urban (Cairo) and rural (Bahtim) areas during the period (1993-1997) revealed that the urban area always has values of G and UV radiation distinctly lower than that found in rural area for all months of the year. Urban-rural mean reduction of G and UV reached 7.0% and 17.9% respectively. The ratio of the ultraviolet to global radiation (UV/G) are calculated and compared with other sites in the Arabian Peninsula. The effect of atmospheric dust on the measured solar radiation components is also investigated and discussed. (author)

  16. Mott insulator-to-metal transition in yttrium-doped CaIrO3

    OpenAIRE

    Gunasekera, J.; Chen, Y.; Kremenak, J. W.; Miceli, P. F.; Singh, D.K.

    2014-01-01

    We report on the study of insulator-to-metal transition in post-perovskite compound CaIrO3. It is discovered that a gradual chemical substitution of calcium by yttrium leads to the onset of strong metallic behavior in this compound. This observation is in stark contrast to BaIrO3, which preserves its Mott insulating behavior despite excess of charge carriers due to yttrium doping. Magnetic measurements reveal that both compounds tend to exhibit magnetic character irrespective of the chemical ...

  17. The practice of home in old Cairo: Towards socio-spatial models of sustainable living

    OpenAIRE

    Abdelmonem, M. Gamal

    2012-01-01

    The article investigates the practice of home as an everyday system for sustainable living in Old Cairo. The idea of home in this historic urban space has long involved fluid socio-spatial associations and made efficient use of space-activity-time dynamics. As in the past, a individual’s sense of home may here extend beyond or shrink within the physical boundaries of a particular house, as spatial settings are produced and consumed according to time of day, gender association, or special even...

  18. Environmental pollution study around a large industrial area near Cairo, Egypt

    International Nuclear Information System (INIS)

    Neutron activation analysis is one of the most extensively used methods for environmental studies due to its high sensitivity, precision, versatility and multielemental character. Cement factories at Helwan, south of Cairo, contribute substantially to environmental pollution. Determination of minor and trace-elements in dust particulates from the cement industrial areas has been performed to assess the air quality from an environmental and human health point of view. Soil-7 standard reference material from IAEA and SRM-1571 from NBS were used for quality assurance testing. The data obtained indicate there is an indication that the pollution could be hazardous to people living in and around the area surveyed. (author)

  19. A five-year analysis of the incidence of glomerulonephritis at Cairo University Hospital-Egypt

    OpenAIRE

    Salwa Ibrahim; Ahmed Fayed; Sawsan Fadda; Dawlet Belal

    2012-01-01

    Our study aimed to obtain a comprehensive review of the incidence of biopsy-proven glomerulonephritis (GN) at the Cairo University Hospitals, Egypt, over the last five years. We analyzed the clinical and pathological data of all renal biopsy samples that were performed during the period from July 2003 to July 2008. Renal biopsy samples of 924 patients were referred for pathological assessment during the period of the study [437 male and 487 female patients; their mean age was 26.5 ± 14.6 year...

  20. Natural radioactivity in different types of bricks fabricated and used in the Cairo region

    International Nuclear Information System (INIS)

    The specific radioactivity concentrations of 226Ra, 232Th and 40K were measured in samples of different types of bricks (clay, cement, and sand) fabricated and used in urban buildings in the Cairo region in Egypt, using a γ-ray spectrometer with a HpGe-detector. The radiation hazard of the total natural radioactivity in the studied brick was estimated by different approaches. The concentrations of the natural radionuclides and the radium-equivalent activity in the studied Egyptian brick samples are compared with the corresponding results for bricks of the different countries and are found to be significantly lower in all cases. (Author)

  1. The Politics of Neglect: the Egyptian State in Cairo, 1974-98

    OpenAIRE

    Dorman, WJ

    2007-01-01

    This thesis examines state-society relations in Egypt, and the logic of durable authoritarianism since 1952. It does so through an examination of the Egyptian state’s neglectful rule, from the 1970s through the 1990s, of its capital Cairo. In particular, the thesis focuses on state inaction vis-à-vis Cairo’s informal housing sector: those neighbourhoods established on land not officially sanctioned for urbanization. The central research question of the thesis is to explain why the Egyptia...

  2. OXA-163-producing Klebsiella pneumoniae in Cairo, Egypt, in 2009 and 2010.

    Science.gov (United States)

    Abdelaziz, Mohammed O; Bonura, Celestino; Aleo, Aurora; El-Domany, Ramadan A; Fasciana, Teresa; Mammina, Caterina

    2012-07-01

    Two genetically unrelated OXA-163-carrying Klebsiella pneumoniae strains were identified from two infection cases in June 2009 and May 2010 in Cairo, Egypt. OXA-163-producing Enterobacteriaceae had been previously reported in Argentina only. Both patients had no history of travel abroad. The emergence of this newly recognized OXA-48-related β-lactamase able to hydrolyze cephalosporins and carbapenems is especially worrying in a geographic area where OXA-48 is endemic and effective surveillance for antibiotic resistance is largely unaffordable. PMID:22518851

  3. A Novel Cross-Disciplinary Multi-Institute Approach to Translational Cancer Research: Lessons Learned from Pennsylvania Cancer Alliance Bioinformatics Consortium (PCABC

    Directory of Open Access Journals (Sweden)

    Ashokkumar A. Patel

    2007-01-01

    Full Text Available Background: The Pennsylvania Cancer Alliance Bioinformatics Consortium (PCABC, http://www.pcabc.upmc.edu is one of the first major project-based initiatives stemming from the Pennsylvania Cancer Alliance that was funded for four years by the Department of Health of the Commonwealth of Pennsylvania. The objective of this was to initiate a prototype biorepository and bioinformatics infrastructure with a robust data warehouse by developing a statewide data model (1 for bioinformatics and a repository of serum and tissue samples; (2 a data model for biomarker data storage; and (3 a public access website for disseminating research results and bioinformatics tools. The members of the Consortium cooperate closely, exploring the opportunity for sharing clinical, genomic and other bioinformatics data on patient samples in oncology, for the purpose of developing collaborative research programs across cancer research institutions in Pennsylvania. The Consortium’s intention was to establish a virtual repository of many clinical specimens residing in various centers across the state, in order to make them available for research. One of our primary goals was to facilitate the identification of cancer specific biomarkers and encourage collaborative research efforts among the participating centers.Methods: The PCABC has developed unique partnerships so that every region of the state can effectively contribute and participate. It includes over 80 individuals from 14 organizations, and plans to expand to partners outside the State. This has created a network of researchers, clinicians, bioinformaticians, cancer registrars, program directors, and executives from academic and community health systems, as well as external corporate partners - all working together to accomplish a common mission. The various sub-committees have developed a common IRB protocol template, common data elements for standardizing data collections for three organ sites, intellectual

  4. CaIrO3 post-perovskite, a j = 1/2 quasi-one-dimensional antiferromagnet

    OpenAIRE

    Bogdanov, Nikolay A.; Katukuri, Vamshi M.; Stoll, Hermann; Brink, Jeroen van den; Hozoi, Liviu

    2012-01-01

    The 5d5 iridate CaIrO3 is isostructural with the post-perovskite phase of MgSiO3, recently shown to occur under extreme pressure in the lower Earth's mantle. It therefore serves as an analogue of post-perovskite MgSiO3 for a wide variety of measurements at ambient conditions or achievable with conventional multianvile pressure modules. By multireference configuration-interaction calculations we here provide essential information on the chemical bonding and magnetic interactions in CaIrO3. We ...

  5. "Cairo must address the equity issue." Interview: Sandra Postel.

    Science.gov (United States)

    1994-01-01

    Sandra Postel, of the Worldwatch Institute, believes that inequalities in consumption and income foster environmental degradation. The richest 20% are getting richer and consuming excessively. The bottom 20%, comprising about 1 billion people, are getting poorer and are degrading their environment in order to survive. Per capita availability of resources is continually being reduced. If there is a desire to improve the quality of life for the poorest segment of the world population, then the richest must forfeit something. Environmental taxation could reduce excessive consumption in general; this strategy would be the most efficient and useful. Taxes would be placed on pollution and resources in danger of depletion; income taxes could be reduced to balance the impact of increased taxes on the economy. Wealthy countries must make a renewed commitment to poverty alleviation and to realistic sustainable development. Aid budgets should no longer reflect military priorities or strategic objectives. Trade is clearly related to the environment and poverty, and these connections must be made publicly known. National and international trade policies must deal with poverty issues and not contribute to further environmental destruction. Eliminating debt problems is another problem in need of change. The World Bank and structural adjustment policies have not proved to be environmentally sound and have not benefitted the poor. Evaluation of programs is needed, and lending policies should reflect the growing awareness of the problems of the poor and environmental consequences. Consumption of energy, wood, paper, and water are all higher among industrialized wealthy countries. Technology needs to be applied to maximize resource use, and policies must reflect this commitment. Israel has set a good example with water consumption reduction through advanced technology. PMID:12345839

  6. A long-term survival pattern for breast cancer treated in a single institution

    Directory of Open Access Journals (Sweden)

    T Gokce

    2011-01-01

    Full Text Available Aim: This paper presents a 14-year retrospective study evaluating the survival rates and prognostic factors of breast carcinoma patients treated in private treatment center in the west coast of Turkey. Materials and Methods: The survival rates of breast cancer patients (n = 1746 who have been treated from 1995 until 2008 were analyzed. The clinical data include age, menopausal stage, oestrogen (ER and progesterone (PR receptor status, and C-erbB-2 status as well as histopathological evaluation. AJCC (2002 was used for clinical tumor staging. Survival rates were computed using standard Kaplan-Meier methods, and the difference in survival curves was analyzed with the log-rank test. Results: The 14-year overall survival, disease-free survival, local failure-free survival, and distant failure-free survival rates were 77%, 95%, 77%, and 94%, respectively. Early-stage patients had higher overall survival rates compared to advanced-stage patients (stage IIIb and IIIc, AJCC 2002, and early-stage patients had higher survival rates than advanced-stage patients for disease-free survival, local failure-free survival, and distant failure-free survival. The risk for cancer development increases significantly for advanced-stage patients with positive ER and PR receptor as well as C-erbB-2 receptor. Conclusions: The incidence of breast cancer in Turkey is smaller compared to other European countries. Low advanced-stage patient numbers compared to high early-stage patient numbers; and very high median survival times could possibly be the result of the improvement of detection and treatment of breast cancer over the years.

  7. Radiotherapy in the cavum cancer: analysis of 30 cases treated in our institution in Beirut

    International Nuclear Information System (INIS)

    The authors describe the results obtained for nasopharyngeal cancers treated by irradiation, exclusively or in combination with chemotherapy. They also assess the impact of the different pathological and clinic variables on survival without relapse. The study is based on a sample of 30 patients treated between 1999 and 2009. Local control, metastatic dissemination, and toxicity are analysed and discussed. A ganglionary extension seems to be the worst prognostic factor. Short communication

  8. Intraoperative Radiotherapy for Pancreatic Cancer: 30-Year Experience in a Single Institution in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Jingu, Keiichi, E-mail: kjingu-jr@rad.med.tohoku.ac.jp [Department of Radiation Oncology, Tohoku University School of Medicine, Sendai (Japan); Tanabe, Takaya [Department of Radiation Oncology, Tohoku University School of Medicine, Sendai (Japan); Nemoto, Kenji [Department of Radiation Oncology, Yamagata University School of Medicine, Yamagata (Japan); Ariga, Hisanori; Umezawa, Rei; Ogawa, Yoshihiro; Takeda, Ken; Koto, Masashi; Sugawara, Toshiyuki; Kubozono, Masaki; Shimizu, Eiji; Abe, Keiko; Yamada, Shogo [Department of Radiation Oncology, Tohoku University School of Medicine, Sendai (Japan)

    2012-07-15

    Purpose: To analyze retrospectively the results of intraoperative radiotherapy (IORT) with or without external beam radiotherapy ({+-} EBRT) for localized pancreatic cancer in the past three decades and to analyze prognostic factors by multivariate analysis. Methods and Materials: Records for 322 patients with pancreatic cancer treated by IORT {+-} EBRT in Tohoku University Hospital between 1980 and 2009 were reviewed. One hundred ninety-two patients who had no distant organ metastases or dissemination at the time of laparotomy were enrolled in the present study. Results: Eighty-three patients underwent gross total resection (R0: 48 patients, R1: 35 patients), and 109 patients underwent only biopsy or palliative resection. Fifty-five patients underwent adjuvant EBRT, and 124 underwent adjuvant chemotherapy. The median doses of IORT and EBRT were 25 and 40 Gy, respectively. The median follow-up period was 37.5 months. At the time of the analysis, 166 patients had disease recurrence, and 35 patients had local failure. The 2-year local control (LC) and overall survival (OS) rates were 71.0% and 16.9%, respectively. Comparison of the results for each decade showed that OS was significantly improved decade by decade (2-year: 25.0% vs. 18.8% vs. 4.2%, p < 0.001). Multivariate analysis showed that degree of resection (R0-1 vs. R2, hazard ratio = 1.97, p = 0.001) and adjuvant chemotherapy (yes vs. no, hazard ratio = 1.54, p = 0.028) had significant impacts on OS. Late gastrointestinal morbidity of Common Terminology Criteria for Adverse Events version 3.0 grade 4 or 5 was observed in four patients. Conclusion: Excellent local control for pancreatic cancer with few cases of severe late toxicity was achieved by using IORT. OS of patients with pancreatic cancer treated by IORT {+-} EBRT improved significantly decade by decade. Multivariate analysis showed that degree of resection and adjuvant chemotherapy had significant impacts on OS.

  9. Cervical Lymph Node Metastases From Unknown Primary Cancer: A Single-Institution Experience With Intensity-Modulated Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Villeneuve, Hugo, E-mail: hugo.villeneuve@umontreal.ca [Department of Radiation Oncology, Centre hospitalier de l' Universite de Montreal, Montreal, QC (Canada); Despres, Philippe; Fortin, Bernard; Filion, Edith; Donath, David [Department of Radiation Oncology, Centre hospitalier de l' Universite de Montreal, Montreal, QC (Canada); Soulieres, Denis [Department of Medical Oncology, Centre hospitalier de l' Universite de Montreal, Montreal, QC (Canada); Guertin, Louis; Ayad, Tarek; Christopoulos, Apostolos [Department of Head and Neck Surgery, Centre hospitalier de l' Universite de Montreal, Montreal, QC (Canada); Nguyen-Tan, Phuc Felix [Department of Radiation Oncology, Centre hospitalier de l' Universite de Montreal, Montreal, QC (Canada)

    2012-04-01

    Purpose: To determine the effectiveness and rate of complications of intensity-modulated radiotherapy (IMRT) in the treatment of cervical lymph node metastases from unknown primary cancer. Methods and Materials: Between February 2005 and November 2008, 25 patients with an unknown primary cancer underwent IMRT, with a median radiation dose of 70 Gy. The bilateral neck and ipsilateral putative pharyngeal mucosa were included in the target volume. All patients had squamous cell carcinoma, except for 1 patient who had adenosquamous differentiation. They were all treated with curative intent. Of the 25 included patients, 20 were men and 5 were women, with a median age of 54 years. Of these patients, 3 had Stage III, 18 had Stage IVa, and 4 had Stage IVb. Of the 25 patients, 18 (72%) received platinum-based chemotherapy in a combined-modality setting. Neck dissection was reserved for residual disease after definitive IMRT. Overall survival, disease-free survival, and locoregional control were calculated using the Kaplan-Meier method. Results: With a median follow-up of 38 months, the overall survival, disease-free survival, and locoregional control rates were all 100% at 3 years. No occurrence of primary cancer was observed during the follow-up period. The reported rates of xerostomia reduced with the interval from the completion of treatment. Nine patients (36%) reported Grade 2 or greater xerostomia at 6 months, and only 2 (8%) of them reported the same grade of salivary function toxicity after 24 months of follow-up. Conclusion: In our institution, IMRT for unknown primary cancer has provided good overall and disease-free survival in all the patients with an acceptable rate of complications. IMRT allowed us to address the bilateral neck and ipsilateral putative pharyngeal mucosa with minimal late salivary function toxicity. The use of concurrent chemotherapy and IMRT for more advanced disease led to good clinical results with reasonable toxicities.

  10. Lung Cancer in Homeless People: Clinical Outcomes and Cost Analysis in a Single Institute

    Directory of Open Access Journals (Sweden)

    Koung Jin Suh

    2016-01-01

    Full Text Available Introduction. To characterize the demographic and clinical features, outcomes, and treatment costs of lung cancer in homeless people. Methods. Medical records of 22 homeless patients with lung cancer at Seoul National University Boramae Medical Center in Seoul, South Korea, were retrospectively analyzed. Results. All patients were men (median age, 62 years. Most patients (78% had advanced disease (stage IIIB, n=2; stage IV, n=15. Seven died during initial hospitalization (median survival, 1.5 months. Six were lost to follow-up after initial outpatient visits or discharges from initial admission (median follow-up, 13 days. Only 4 received appropriate treatment for their disease and survived for 1, 15, 19, and 28 months, respectively. Conversely, 4 of 5 patients with early stage disease (stage I, n=4; stage IIA, n=1 received curative surgery (median follow-up 25.5 months. The median treatment cost based on 29 days of hospitalization and 2 outpatient visits was $12,513, constituting 47.3% of the 2013 per capita income. Inpatient treatment accounted for 90% of the total costs. The National Health Insurance Service paid 82% of the costs. Conclusion. Among the homeless, lung cancer seems to be associated with poor prognosis and substantial costs during a relatively short follow-up and survival period.

  11. CPRIT/Johnson Space Center, September, 2011 (Cancer Prevention and Research Institute of Texas)

    Science.gov (United States)

    Davis, Jeffrey; Lane, Helen; Baker, Tracey; Cucinotta, Francis; Wu, Honglu

    2011-01-01

    JSC researchers study carcinogenesis, cancer prevention and treatment along with epidemiological (primarily retrospective and longitudinal) studies, modeling, and interactions with the environment such as radiation, nutritional, and endocrine changes related to space flight along with behaviors such as smoking. Cancer research is a major focus for human space flight due to the exposure to space radiation which consists of particles of varying charges and energies, and secondary neutrons. The JSC laboratories collaborate with investigators from the U.S. as well as our European and Japanese partners. We use accelerator facilities at the Brookhaven National Laboratory, Loma Linda University and Los Alamos National Laboratory that generate high energy charged particles and neutrons to simulate cosmic radiation and solar particle events. The research using cultured cells and animals concentrates on damage and repair from the level of DNA to organ tissues, due to exposure to simulated space radiation exposure, that contribute to the induction of leukemia and solid tumors in most major tissues such as lung, colon, liver and breast. The goal of the research is to develop a mathematical model that can predict cancer morbidity and mortality risks with sufficient accuracy for a given space mission.

  12. Nature of the Insulating Ground State of the 5 d Postperovskite CaIrO3

    Science.gov (United States)

    Kim, Sun-Woo; Liu, Chen; Kim, Hyun-Jung; Lee, Jun-Ho; Yao, Yongxin; Ho, Kai-Ming; Cho, Jun-Hyung

    2015-08-01

    The insulating ground state of the 5 d transition metal oxide CaIrO3 has been classified as a Mott-type insulator. Based on a systematic density functional theory (DFT) study with local, semilocal, and hybrid exchange-correlation functionals, we reveal that the Ir t2 g states exhibit large splittings and one-dimensional electronic states along the c axis due to a tetragonal crystal field. Our hybrid DFT calculation adequately describes the antiferromagnetic (AFM) order along the c direction via a superexchange interaction between Ir4 + spins. Furthermore, the spin-orbit coupling (SOC) hybridizes the t2 g states to open an insulating gap. These results indicate that CaIrO3 can be represented as a spin-orbit Slater insulator, driven by the interplay between a long-range AFM order and the SOC. Such a Slater mechanism for the gap formation is also demonstrated by the DFT + dynamical mean field theory calculation, where the metal-insulator transition and the paramagnetic to AFM phase transition are concomitant with each other.

  13. Nature of the insulating ground state of the 5d postperovskite CaIrO3

    International Nuclear Information System (INIS)

    In this study, the insulating ground state of the 5d transition metal oxide CaIrO3 has been classified as a Mott-type insulator. Based on a systematic density functional theory (DFT) study with local, semilocal, and hybrid exchange-correlation functionals, we reveal that the Ir t2g states exhibit large splittings and one-dimensional electronic states along the c axis due to a tetragonal crystal field. Our hybrid DFT calculation adequately describes the antiferromagnetic (AFM) order along the c direction via a superexchange interaction between Ir4+ spins. Furthermore, the spin-orbit coupling (SOC) hybridizes the t2g states to open an insulating gap. These results indicate that CaIrO3 can be represented as a spin-orbit Slater insulator, driven by the interplay between a long-range AFM order and the SOC. Such a Slater mechanism for the gap formation is also demonstrated by the DFT + dynamical mean field theory calculation, where the metal-insulator transition and the paramagnetic to AFM phase transition are concomitant with each other

  14. Impact of industrial wastewater disposal on surface water bodies in Mostord area north Greater Cairo

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The studied area (Shoubra El-Khima, Bahteem and Mostorod) lies in the industrial area north of Greater Cairo. The area suffers from several environmental problems such as sewage and disposal of pollutants from the surrounding factories into the surface water pathways in the area. Water samples were collected seasonally from different waterways found in the area, domestic and or industrial liquid wastes from 12 discharge tubes of different factories (as a point source of pollution). Chemical characteristics of different water samples and its heavy metals content were determined using ion coupled plasma technique (ICP). Results indicate that industrial and domestic wastewater samples contain several toxic levels of tested heavy metals (Cd, Co, Pb and Ni) which have a serious impact on surface waterways in the area.Shebin El-Qanater collector drain samples exhibited the highest levels of Cd, Co, Pb and Ni compared to other tested water bodies Mostorod collector drain samples showed the highest levels of Zn and Cu. Industrial effluent samples collected from Cairo Company for Fabric industry had the highest amounts of total Zn Cu, Cd, Co and Pb, while Delta steel company discharges the highest amounts of total Fe and Mn. Al-Ahleya Plastic Company discharges the highest amounts of total-Ni. Generally, it is necessary to impose the environmental laws and its regulation regarding the industrial wastewater treatments and disposals to minimize the risk of the adverse effects of these pollutants.

  15. Evaluation of The Surface Ozone Concentrations In Greater Cairo Area With Emphasis On Helwan, Egypt

    International Nuclear Information System (INIS)

    Various biogenic and anthropogenic sources emit huge quantities of surface ozone. The main purpose of this study is to evaluate the surface ozone levels present at Helwan area in order to improve the knowledge and understanding troposphere processes. Surface Ozone has been measured at 2 sites at Helwan; these sites cover the most populated area in Helwan. Ozone concentration is continuously monitored by UV absorption photometry using the equipment O3 41 M UV Photometric Ozone Analyzer. The daily maximum values of the ozone concentration in the greater Cairo area have approached but did not exceeded the critical levels during the year 2008. Higher ozone concentrations at Helwan are mainly due to the transport of ozone from regions further to the north of greater Cairo and to a lesser extent of ozone locally generated by photochemical smog process. The summer season has the largest diurnal variation, with the tendency of the daily ozone maxima occur in the late afternoon. The night time concentration of ozone was significantly higher at Helwan because there are no fast acting sinks, destroying ozone since the average night time concentration of ozone is maintained at 40 ppb at the site. No correlation between the diurnal total suspended particulate (TSP) matter and the diurnal cumulative ozone concentration was observed during the Khamasin period

  16. OPTIMIZATION PROCEDURE FOR PRELIMINARY DESIGN STAGE OF CAIRO-DAMIETTA SELF-PROPELLED GRAIN BULK SHIPS

    Directory of Open Access Journals (Sweden)

    M.M. Moustafa

    2016-01-01

    Full Text Available The global logistics center for the storage and handling of grain which will be constructed at Damietta port will extremely increase the annual movement of grain through Cairo-Damietta waterway. Therefore, the demand for inland grain bulk ships has increased significantly in the recent years. This paper introduces a procedure to find out the fleet size and optimum characteristics of self-propelled grain bulk ships working between Cairo and Damietta through River Nile. The characteristics of the Cairo–Damietta waterway are investigated to define the constraints on dimensions and speed for such ship type. Also, mathematical model for the objective function was developed considering: powering, voyage, weight, stability and cost calculation. In this research, Specific cost (Sc, cost of transporting one ton of cargo a distance of one kilometre, is considered as the objective function for this optimization process. This optimization problem is handled as a single objective nonlinear constrained optimization problem using a specially developed computer program. Solutions are generated by varying design variables systematically in certain steps. The best of these solutions is then taken as the estimated optimum. Finally, the problem is presented, the main constrains analyzed and the optimum solution shown.

  17. The extent of nonmedical use of psychoactive substances among secondary school students in Greater Cairo.

    Science.gov (United States)

    Soueif, M I; El-Sayed, A M; Darweesh, Z A; Hannourah, M A

    1982-02-01

    The present paper reports on an epidemiological study of the nonmedical use of psychoactive substances among male secondary school students in Greater Cairo. A standardized questionnaire was administered to 5530 male pupils constituting a representative sample of all male students in Cairo secondary schools. The main aim of the study was to provide factual answers to questions pertaining to, (a) the extent of the use of psychoactive drugs, and (b) the aetiology of such use, among secondary school students. Methodological steps undertaken to provide for representativeness of the sample and credibility of the tool are described. Among the interesting results were the following: (1) consistently more arts students than pupils reading science and maths were immersed in the drug culture; (2) sizable numbers of young people get exposed to the drug culture through well defined psychosocial channels; (3) the role of mass media in effecting this exposure seems to be quite serious, ranking in most cases after the role of personal friends; (4) a differentiation between "activists" and "passivists" among subjects who "ever used" drugs seems to be important in understanding more about drug use phenomena, and (5) some findings add a new dimension to the operational definition of high risk groups: a subgroup of nonusers could be labeled "potential users". PMID:7084022

  18. A simple technique for the generation of institution-specific nomograms for permanent prostate cancer brachytherapy

    OpenAIRE

    Lafata, Kyle J.; Bushe, Harry; Aronowitz, Jesse N.

    2014-01-01

    Purpose Nomograms once had a vital role in prostate brachytherapy practice. Although some of their functions have been assumed by computerized dosimetry, many programs still find them useful to determine the number and strength of seeds to be ordered in advance of the implant. As it has been demonstrated that brachytherapists differ in their implant practices and preferences (in regard to seed distribution and total implanted activity), we propose a simple technique for generating institution...

  19. 77 FR 76453 - Opportunity for Designation in Amarillo, TX; Cairo, IL; Baton Rouge, LA; Raleigh, NC; and Belmond...

    Science.gov (United States)

    2012-12-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Grain Inspection, Packers and Stockyards Administration Opportunity for Designation in Amarillo, TX; Cairo, IL; Baton Rouge, LA; Raleigh, NC; and Belmond, IA Areas; Request for Comments on the...

  20. Agreement for the Establishment in Cairo of a Middle Eastern Regional Radioisotope Centre for the Arab Countries

    International Nuclear Information System (INIS)

    On 14 September 1962 the Board of Governors approved an Agreement for the establishment in Cairo of a Middle Eastern regional radioisotope centre for the Arab countries. The text of this Agreement is reproduced in this document for the information of all Members

  1. Comparison of two different treatment regimens for cancer of uterine cervix as practised in our institute: a retrospective analysis

    International Nuclear Information System (INIS)

    Starting from the early days of radiotherapy practice till today, cancer of female uterine cervix is the most common malignant disease in India. A number of treatment modalities are being used for the treatment of this disease. Earlier, Wertheim's hysterectomy was the primary line of treatment. But due to poor cosmetic results and other complications, nowadays radiotherapy is the most preferred modality for the radical treatment of this commonest malignancy. Due to the lack of any universally accepted radiotherapy treatment regime, different oncology therapists within the same institute are practising different regimens derived from their own clinical practice experience. Majority of the patients are treated with two parallel opposed (AP-PA) portals up to 40 Gy, then 10 Gy dose is delivered using central shield to avoid overdose to bladder and rectum and to get dose uniformity caused by I/C application. External irradiation was delivered by a 60Co photon beam

  2. Multidisciplinary Service Utilization Pattern by Advanced Head and Neck Cancer Patients: A Single Institution Study

    Directory of Open Access Journals (Sweden)

    Jacqueline C. Junn

    2012-01-01

    Full Text Available Purpose. To analyze the patterns and associations of adjunctive service visits by head and neck cancer patients receiving primary, concurrent chemoradiation therapy. Methods. Retrospective chart review of patients receiving adjunctive support during a uniform chemoradiation regimen for stages III-IV head and neck squamous cell carcinoma. Univariate and multivariate models for each outcome were obtained from simple and multivariate linear regression analyses. Results. Fifty-two consecutive patients were assessed. Female gender, single marital status, and nonprivate insurance were factors associated with an increased number of social work visits. In a multivariate analysis, female gender and marital status were related to increased social work services. Female gender and stage IV disease were significant for increased nursing visits. In a multivariate analysis for nursing visits, living greater than 20 miles between home and hospital was a negative predictive factor. Conclusion. Treatment of advanced stage head and neck cancer with concurrent chemoradiation warrants a multidisciplinary approach. Female gender, single marital status, and stage IV disease were correlated with increased utilization of social work and nursing services. Distance over 20 miles from the center was a negative factor. This information may help guide the treatment team to allocate resources for the comprehensive care of patients.

  3. Advocacy resource: engaging the media and promoting your cancer program in Africa

    OpenAIRE

    Reams, R Renee; Odedina, Folakemi T; Pressey, Shannon

    2013-01-01

    To address the need for a significant increase in cancer advocacy programs in Africa, the University of Florida (UF), the Prostate Net, and the African Organization for Research and Training in Cancer (AORTIC) co-hosted the first biennial International Workshop on Cancer Advocacy for African Countries (CAAC) on November 29, 2011, one-day prior to AORTIC’s 8th International Cancer Conference in Cairo, Egypt. Over 70 African cancer advocates representing about 12 African countries participated ...

  4. Displacements of fiducial markers in patients with prostate cancer treated with image guided radiotherapy: A single-institution descriptive study

    Science.gov (United States)

    Cendales, Ricardo; Torres, Felipe; Arbelaez, Juan; Gaitan, Armando; Vasquez, Jaider; Bobadilla, Ivan

    2014-01-01

    Aim To describe daily displacements when using fiducial markers as surrogates for the target volume in patients with prostate cancer treated with IGRT. Background The higher grade of conformity achieved with the use of modern radiation technologies in prostate cancer can increase the risk of geographical miss; therefore, an associated protocol of IGRT is recommended. Materials and methods A single-institution, retrospective, consecutive study was designed. 128 prostate cancer patients treated with daily on-line IGRT based on 2D kV orthogonal images were included. Daily displacement of the fiducial markers was considered as the difference between the position of the patient when using skin tattoos and the position after being relocated using fiducial markers. Measures of central tendency and dispersion were used to describe fiducial displacements. Results The implant itself took a mean time of 15 min. We did not detect any complications derived from the implant. 4296 sets of orthogonal images were identified, 128 sets of images corresponding to treatment initiation were excluded; 91 (2.1%) sets of images were excluded from the analysis after having identified that these images contained extreme outlier values. If IGRT had not been performed 25%, 10% or 5% of the treatments would have had displacements superior to 4, 7 or 9 mm respectively in any axis. Conclusions Image guidance is required when using highly conformal techniques; otherwise, at least 10% of daily treatments could have significant displacements. IGRT based on fiducial markers, with 2D kV orthogonal images is a convenient and fast method for performing image guidance. PMID:25535583

  5. Patterns of Resection among Patients with Hepatic-Only Metastatic Colorectal Cancer a Single Institution Experience and Review

    Directory of Open Access Journals (Sweden)

    K. I. Quintyne

    2012-01-01

    Full Text Available Problem statement: Hepatic-only metastasis in colorectal cancer is not a rare clinical finding and can account for 30% of cases. However, only 10-25% of cases are suitable for hepatic resection as part of their treatment pathway. We sought to document our own findings by reviewing patients with hepatic-only disease. Approach: A retrospective analysis was designed to include all patients seen at our institution from 1st January 2000 until 30th June 2010 and information as derived from the patients� records. Results: Forty-four (44 patients were found, with an average age of 60.8 years and a male preponderance. The majority of patients (approximately 57% with hepatic-only metastases developed their disease following adjuvant therapy. Better overall survival was seen when a primary tumor had a low grade of histological differentiation and fewer than 3 hepatic lesions appreciated on conventional radiology. Better outcome was seen in patients who underwent hepatic resection. Conclusion: Patients with hepatic-only metastases are not uncommon within our institution. Hepatic resection afforded better outcome and compares favorably with published literature.

  6. The costs of breast cancer in a Mexican public health institution

    Directory of Open Access Journals (Sweden)

    Jacobo Alejandro Gómez-Rico

    2008-11-01

    Full Text Available Jacobo Alejandro Gómez-Rico1, Marina Altagracia-Martínez1, Jaime Kravzov-Jinich1, Rosario Cárdenas-Elizalde1, Consuelo Rubio-Poo21Universidad Autónoma Metropolitano–Xochimilco (UAM-X, Departments: Biological Systems and Healthcare, Biological and Health Sciences Division (DCBS; 2Universidad Nacional Autónoma de México (UNAM, Faculty of Professional Studies-Zaragoza (FES-ZaragozaAbstract: Breast cancer (BC is the second leading cause of death as a result of neoplasia in Mexico. This study aimed to identify the direct and indirect costs of treating female outpatients diagnosed with BC at a Mexican public hospital. A cross-sectional, observational, analytical study was conducted. A total of 506 medical records were analyzed and 102 were included in the cost analysis. The micro-costing process was used to estimate treatment costs. A 17-item questionnaire was used to obtain information on direct and indirect costs. Of the 102 women with BC included in the study, 92.2% (94 were at Stage II, and only 7.8% at Stage I. Total direct costs over six months for the 82 women who had modified radical mastectomy (MRM surgury were US$733,821.15. Total direct costs for the 15 patients with conservative surgery (CS were US$138,190.39. We found that the total economic burden in the study population was much higher for patients with MRM than for patients with CS.Keywords: breast cancer, Mexican women, direct and indirect costs

  7. Retrospective study of positive physical torture cases in Cairo (2009 & 2010).

    Science.gov (United States)

    Ghaleb, Sherein Salah; Elshabrawy, Ekram Mohamad; Elkaradawy, Magda Helal; Nemr Welson, Nermeen

    2014-05-01

    Torture is the most serious violation of a person's fundamental right to personal integrity and a pathological form of human interaction. In this study, the prevalence of torture in Cairo during the years 2009 & 2010 is 10.97% of the total number of cases examined at the medico legal authority of Egypt in Zenhom (11.29% in 2010 & 10.36% in 2009). The number of cases under this study is 367 (175 cases in 2009, 192 cases in 2010). Torture is more prevalent in the year 2010 than in the year 2009. The largest prevalence of torture was found in the area of south Cairo (120 cases; 32.7%) while the least was found in the area of west Cairo (50 cases; 13.6%). The victims included 336 males (91.6%) and 31 females (8.4%) with male to female ratio 10.8: 1. The most commonly affected age group in the studied victims was the age group of the third decade (171 cases; 46.6%) while the least was the age group above the sixth decade (6 cases; 1.6%). The most commonly affected site of injury was head & neck (243 cases; 66.2%) while the least was abdomen (17 cases; 4.6%). The most common type of injury was bruises (258 cases; 70.3%) while the least was electrocution (5 cases; 1.4%). Regarding the causal instrument, the most commonly used instrument was blunt object (333 cases; 90.7%) while the least was electric current (5 cases; 10%). Hitting with a stick leaving the characteristic shape of elongated abrasion & bruises was found in 35 cases (9.5%) and characteristic lesion of handcuff, which is blunt trauma wounds around wrists or ankles, was found in 68 cases (18.5%). There was one case of hair torture (0.3%) & 5 cases of sexual torture (1.5%). Permanent infirmity left in victims was positive in 24 cases (6.5%) and negative in 343 cases (93.5%) while deformity left in victims was positive in 10 cases (3%) and negative in 357 cases (97%). All permanent infirmity cases were male. Of the 24 cases of permanent infirmity, 83.3% were subjected to blunt trauma and 79.2% were injured in

  8. Decade evaluation of management of differentiated thyroid cancer in National Anticancer Institute

    International Nuclear Information System (INIS)

    Full text: Although the differentiated thyroid cancer (DTC) has proven to have a good prognosis with significant decreases in mortality rates, many countries recently witnessed an increase in incidence of this pathology. In this respect, this study aims to assess 10 years of DTC management in the national cancer centre through a population survey. Materials and methods: 750 patients were referred to the department of endocrinology and nuclear medicine, Pierre and Marie curie centre for DTC management between 1996 and 2005. All patients have undergone a surgery with total thyroidectomy even for papillary microcarcinoma followed by an iodine 131 ablation (3.7 GBq). Results: This study confirms that the DTC incidence increased through the years, essentially from 2001(between 2 to 3 times).The incidence rate for the female sex is 6 times greater than that for males (86% vs. 14%) with a median age at diagnosis stage between 30 to 49 years in 49% of patients. In 64 % of the cases (33% for solitary nodule), the multinodular goiter is the principal reason for the first consultation. Even though the fine needle aspiration biopsy (FNA) was performed only in 30% of patients, 70% were malignant. The papillary histology type is 5 times more frequent than the follicular type (75% vs. 16%). The mean time for radioiodine therapy after surgery has decreased from 34 months in 1996 to 7 months in 2005. 86% of patients have received an activity of 3.7GBq of I-131, while 9% have received 7.4GBq and 5% received more than 7.4GBq. After a minimum follow-up of one year, 78% of patients have had an undetectable Tg. Conclusion: Although an increased incidence rate of DTC has been observed since 2001, the reasons, according to our understanding, are due to the early stage diagnosis using FNA, the frequent availability of ultrasonography neck and the multidisciplinary approach, rather than the fallout atmosphere of radioactive iodine or the population's exposure to thyroid radiation, for

  9. Security and privacy requirements for a multi-institutional cancer research data grid: an interview-based study

    Directory of Open Access Journals (Sweden)

    Weems William A

    2009-06-01

    Full Text Available Abstract Background Data protection is important for all information systems that deal with human-subjects data. Grid-based systems – such as the cancer Biomedical Informatics Grid (caBIG – seek to develop new mechanisms to facilitate real-time federation of cancer-relevant data sources, including sources protected under a variety of regulatory laws, such as HIPAA and 21CFR11. These systems embody new models for data sharing, and hence pose new challenges to the regulatory community, and to those who would develop or adopt them. These challenges must be understood by both systems developers and system adopters. In this paper, we describe our work collecting policy statements, expectations, and requirements from regulatory decision makers at academic cancer centers in the United States. We use these statements to examine fundamental assumptions regarding data sharing using data federations and grid computing. Methods An interview-based study of key stakeholders from a sample of US cancer centers. Interviews were structured, and used an instrument that was developed for the purpose of this study. The instrument included a set of problem scenarios – difficult policy situations that were derived during a full-day discussion of potentially problematic issues by a set of project participants with diverse expertise. Each problem scenario included a set of open-ended questions that were designed to elucidate stakeholder opinions and concerns. Interviews were transcribed verbatim and used for both qualitative and quantitative analysis. For quantitative analysis, data was aggregated at the individual or institutional unit of analysis, depending on the specific interview question. Results Thirty-one (31 individuals at six cancer centers were contacted to participate. Twenty-four out of thirty-one (24/31 individuals responded to our request- yielding a total response rate of 77%. Respondents included IRB directors and policy-makers, privacy and

  10. CYP17 genetic variation and risk of breast and prostate cancer from the national Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)

    NARCIS (Netherlands)

    Setiawan, Veronica Wendy; Schumacher, Fredrick R.; Haiman, Christopher A.; Stram, Daniel O.; Albanes, Demetrius; Altshuler, David; Berglund, Gran; Buring, Julie; Calle, Eugenia E.; Clavel-Chapelon, Francoise; Cox, David G.; Gaziano, J. Michael; Hankinson, Susan E.; Hayes, Richard B.; Henderson, Brian E.; Hirschhorn, Joel; Hoover, Robert; Hunter, David J.; Kaaks, Rudolf; Kolonel, Laurence N.; Kraft, Peter; Ma, Jing; Le Marchand, Loic; Linseisen, Jakob; Lund, Eiliv; Navarro, Carmen; Overvad, Kim; Palli, Domenico; Peeters, Petra H. M.; Pike, Malcolm C.; Riboli, Elio; Stampfer, Meir J.; Thun, Michael J.; Travis, Ruth; Trichopoulos, Dimitrios; Yeager, Meredith; Ziegler, Regina G.; Feigelson, Heather Spencer; Chanock, Stephen J.

    2007-01-01

    CYP17 encodes cytochrome p450c17 alpha, which mediates activities essential for the production of sex steroids. Common germ line variation in the CYP17 gene has been related to inconsistent results in breast and prostate cancer, with most studies focusing on the nonsynonymous single nucleotide polym

  11. NATURAL RADIOACTIVITY LEVELS IN SOME SURFACE SOILS OF HELIOPOLIS AND NASR CITY, CAIRO, EGYPT

    International Nuclear Information System (INIS)

    The levels of natural radioactivity in thirty soil samples collected from Heliopolis and Nasr city, Cairo, Egypt, were measured. The concentrations of radionuclides in samples were determined by gamma ray spectrometer using hyper pure germanium (HPGe) detector. The obtained activity concentrations of Ra-226 and thorium series as well as K-40 in the studied samples were discussed. The total gamma absorbed dose rate in air (nGy/h), the annual effective dose (mSv/y) and the external hazard were measured and compared with the recommended limits from the UNSCEAR data. The high K-40 value is mainly due to the presence of orthoclase mineral in the studied samples, whereas high radiation levels are due to the presence of zircon and monazite minerals in samples

  12. Mechanism of the CaIrO3 post-perovskite phase transition under pressure

    Science.gov (United States)

    Xiao, Penghao; Cheng, Jin-Guang; Zhou, Jian-Shi; Goodenough, John B.; Henkelman, Graeme

    2013-10-01

    Recent experiments have shown that the perovskite to post-perovskite phase transformation in CaIrO3 occurs more readily at room temperature when a shear stress is applied as compared to isotropic pressure. To understand this mechanistically, we have calculated the minimum-energy pathway of the phase transition with density functional theory under different pressure conditions with the generalized solid-state nudged elastic band method. Our results reveal that shear stress significantly lowers the barrier and stabilizes the product state while isotropic pressure initially raises the barrier and only reduces the barrier at pressures above 90 GPa. The nonmonotonic change in barrier with isotropic pressure is explained in terms of an increase in the activation volume under low pressure and a decrease under high pressure.

  13. A study of sand deposit caused by a dust storm on Cairo Area

    International Nuclear Information System (INIS)

    A severe storm attacked Cairo and Most of the Delta in february 3rd, 1992. A satellite photograph and synoptic charts of surface and upper atmosphere were studied to follow the depression (center of the storm) creating strong winds. Deposited dust during the storm was collected outside and inside the city. Desert soil as well as the collected dust samples were mechanically analyzed and the relation between dust grain size and weight was performed as such. Also, a statistical test has been done, which showed simplification correlation between soil and boundary deposits. Deposition rates reached 2.32 kg/m2 at a residential area in the city (Dokki). The results show clearly the importance of barriers of trees surrounding the city particularly the west borders with desert

  14. Prevalence of Bacillus cereus in milk and rice grains collected from great Cairo

    International Nuclear Information System (INIS)

    Sixty two Samples of heat treated milk, raw rice grains and Cheetos (XO-Snacks) were collected from supermarkets of great Cairo. Seventeen out of 25 milk samples (68%) gave detectable count of B. cereus on MYP medium. These positive samples count was ranging from 1.5 X 101 cfu/ml to 11.3X102 cfu/ml. Eighteen out of 25 Samples of raw rice grains (72%) gave also detectable count on MYP medium also. The count of positive rice grains was ranging from 2.0X101 cfu/g to 11.5X103 cfu /ml. However one Sample out of 12 Samples (8%) of Cheetos (Snacks) was positive with count 3.0X102 cfu /g. Gamma irradiation reduced the total bacterial count and B. cereus count gradually. Eight kGy reduced total bacterial count and Bacillus cereus count by 3.1 and 2.2 log cycles respectively.

  15. From Cairo to the Straits Settlements: Modern Salafiyyah Reformist Ideas in Malay Peninsula

    Directory of Open Access Journals (Sweden)

    Hafiz Zakariya

    2007-12-01

    Full Text Available Abstract: Early twentieth-century Malay Peninsula witnessed the emergence of Islamic reform movements. The Malay reformists who were discontented with the socio-economic and political conditions of the Malays criticised the Malay elites and called for “reformation” of their society. The Malay reformists derived inspirations for their reformist ideology from the leading Middle Eastern reformists, Muhammad ≤Abduh, Rashīd Riḍā and others, known as salafiyyah. Available data suggest that the transmission of salafiyyah ideas in particular, and Middle Eastern reformism in general, to Malay Peninsula were made possible by many factors. Of these factors, the roles of the ḥaramayn, the centres of learning in Cairo and the invention of printing machines have been least explored. This study attempts to fill in the void in the existing literature.

  16. Preparation of Database for Land use Management in North East of Cairo

    International Nuclear Information System (INIS)

    Environmental management in urban areas is difficult due to the amount and miscellaneous data needed for decision making. This amount of data is splendid without adequate database systems and modern methodologies. A geo-database building for East Cairo City Area (ECCA) is built to be used in the process of urban land-use suitability to achieve better performance compared with usual methods used. This Geo-database has required availability of detailed, accurate, updated and geographically referenced data on its terrain physical characteristics and its expected environmental hazards that may occur. A smart environmental suitability model for ECCA is developed and implemented using ERDAS IMAGINE 9.2. This model is capable of suggesting the more appropriate urban land-use, based on the existing spatial and non-spatial potentials and constraints.

  17. Sources of PM(10) and PM (2.5) in Cairo's ambient air.

    Science.gov (United States)

    Abu-Allaban, M; Lowenthal, D H; Gertler, A W; Labib, M

    2007-10-01

    A source attribution study was performed to assess the contributions of specific pollutant source types to the observed particulate matter (PM) levels in the greater Cairo Area using the chemical mass balance (CMB) receptor model. Three intensive ambient monitoring studies were carried out during the period of February 21-March 3, 1999, October 27-November 27, 1999, and June 8-June 26, 2002. PM(10), PM(2.5), and polycyclic aromatic hydrocarbons (PAHs) were measured on a 24-h basis at six sampling stations during each of the intensive periods. The six intensive measurement sites represented background levels, mobile source impacts, industrial impacts, and residential exposure. Major contributors to PM(10) included geological material, mobile source emissions, and open burning. PM(2.5) tended to be dominated by mobile source emissions, open burning, and secondary species. This paper presents the results of the PM(10) and PM(2.5), source contribution estimates. PMID:17268919

  18. Lifestyle and cancer prevention in female employees at a health institution

    Directory of Open Access Journals (Sweden)

    Gladys Eugenia Canaval

    2011-06-01

    Full Text Available Objective: To establish the relationship between lifestyle for prevention of cervix and breast cancer and perceptual cognitive factors from the Pender model in working women. Materials and methods: Correlation and cross-sectional study with a random sample of 143 working women. The Lifestyle index is the total score of 5 variables: Papanicolau test, breast self-exam, physical activity, body mass index, and cigarette smoking. Results: The mean age for the sample was 44.4 + 6.2; 87% of the women had higher education and 85% were working in health care services. A total of 89% of the women had unhealthy lifestyles because of the lack of regular physical activity, not having a Papanicolau test according to the norm, not practicing breast self-exams, and having an altered body mass index. There was significant correlation between lifestyle and occupation, and also with self-efficacy perception for breast self-examination. Conclusion: The lifestyles for most of the women sampled were unhealthy. Recommendations: It is also recommend conducting culturally sensitive healthcare campaigns in addition to setting up flexible attention schedules for women.

  19. Lifestyle and cancer prevention in female employees at a health institution

    Directory of Open Access Journals (Sweden)

    Gladys Eugenia Canaval

    2011-06-01

    Full Text Available Objective: To establish the relationship between lifestyle for prevention of cervix and breast cancer and perceptual cognitive factors from the Pender model in working women.Materials and methods: Correlation and cross-sectional study with a random sample of 143 working women. The Lifestyle index is the total score of 5 variables: Papanicolau test, breast self-exam, physical activity, body mass index, and cigarette smoking.Results: The mean age for the sample was 44.4 + 6.2; 87% of the women had higher education and 85% were working in health care services. A total of 89% of the women had unhealthy lifestyles because of the lack of regular physical activity, not having a Papanicolau test according to the norm, not practicing breast self-exams, and having an altered body mass index. There was significant correlation between lifestyle and occupation, and also with self-efficacy perception for breast self-examination.Conclusion: The lifestyles for most of the women sampled were unhealthy.Recommendations: It is recommend the reorientation of health services based on health promotion, which permit planning and executing health care, health education and nursing care programs specifically for working women. It is also recommend conducting culturally sensitive.

  20. Yttrium-90 Radioembolization for Colorectal Cancer Liver Metastases: A Single Institution Experience

    Science.gov (United States)

    Nace, Gary W.; Steel, Jennifer L.; Amesur, Nikhil; Zajko, Albert; Nastasi, Bryon E.; Joyce, Judith; Sheetz, Michael; Gamblin, T. Clark

    2011-01-01

    Purpose. We sought to evaluate our experience using yttrium-90 (90Y) resin microsphere hepatic radioembolization as salvage therapy for liver-dominant metastatic colorectal cancer (mCRC). Methods. A retrospective review of consecutive patients with unresectable mCRC who were treated with 90Y after failing first and second line systemic chemotherapy. Demographics, treatment dose, biochemical and radiographic response, toxicities, and survival were examined. Results. Fifty-one patients underwent 90Y treatments of which 69% were male. All patients had previously undergone extensive chemotherapy, 31% had undergone previous liver-directed therapy and 24% had a prior liver resection. Using RECIST criteria, either stable disease or a partial response was seen in 77% of patients. Overall median survival from the time of first 90Y treatment was 10.2 months (95% CI = 7.5–13.0). The absence of extrahepatic disease at the time of treatment with 90Y was associated with an improved survival, median survival of 17.0 months (95% CI = 6.4–27.6), compared to those with extrahepatic disease at the time of treatment with 90Y, 6.7 months (95% CI = 2.7–10.6 Conclusion: 90Y therapy is a safe locoregional therapy that provides an important therapeutic option to patients who have failed first and second line chemotherapy and have adequate liver function and performance status. PMID:22312513

  1. Yttrium-90 Radioembolization for Colorectal Cancer Liver Metastases: A Single Institution Experience

    Directory of Open Access Journals (Sweden)

    Gary W. Nace

    2011-01-01

    Full Text Available Purpose. We sought to evaluate our experience using yttrium-90 (90Y resin microsphere hepatic radioembolization as salvage therapy for liver-dominant metastatic colorectal cancer (mCRC. Methods. A retrospective review of consecutive patients with unresectable mCRC who were treated with 90Y after failing first and second line systemic chemotherapy. Demographics, treatment dose, biochemical and radiographic response, toxicities, and survival were examined. Results. Fifty-one patients underwent 90Y treatments of which 69% were male. All patients had previously undergone extensive chemotherapy, 31% had undergone previous liver-directed therapy and 24% had a prior liver resection. Using RECIST criteria, either stable disease or a partial response was seen in 77% of patients. Overall median survival from the time of first 90Y treatment was 10.2 months (95% CI = 7.5–13.0. The absence of extrahepatic disease at the time of treatment with 90Y was associated with an improved survival, median survival of 17.0 months (95% CI = 6.4–27.6, compared to those with extrahepatic disease at the time of treatment with 90Y, 6.7 months (95% CI = 2.7–10.6 Conclusion: 90Y therapy is a safe locoregional therapy that provides an important therapeutic option to patients who have failed first and second line chemotherapy and have adequate liver function and performance status.

  2. Thermal equation of state of CaIrO3 post-perovskite

    Science.gov (United States)

    Liu, Wei; Whitaker, Matthew L.; Liu, Qiong; Wang, Liping; Nishiyama, Norimasa; Wang, Yanbin; Kubo, Atsushi; Duffy, Thomas S.; Li, Baosheng

    2011-05-01

    The pressure-volume-temperature ( P- V- T) relation of CaIrO3 post-perovskite (ppv) was measured at pressures and temperatures up to 8.6 GPa and 1,273 K, respectively, with energy-dispersive synchrotron X-ray diffraction using a DIA-type, cubic-anvil apparatus (SAM85). Unit-cell dimensions were derived from the Le Bail full profile refinement technique, and the results were fitted using the third-order Birth-Murnaghan equation of state. The derived bulk modulus K_{T0} at ambient pressure and temperature is 168.3 ± 7.1 GPa with a pressure derivative K_{T0}^' } = 5.4 ± 0.7. All of the high temperature data, combined with previous experimental data, are fitted using the high-temperature Birch-Murnaghan equation of state, the thermal pressure approach, and the Mie-Grüneisen-Debye formalism. The refined thermoelastic parameters for CaIrO3 ppv are: temperature derivative of bulk modulus (partial KT /partial T)P = -0.038 ± 0.011 GPa K-1, α KT = 0.0039 ± 0.0001 GPa K-1, ( {partial KT /partial T} )V = -0.012 ± 0.002 GPa K-1, and ( {partial2 P/partial T2 } )V = 1.9 ± 0.3 × 10-6 GPa2 K-2. Using the Mie-Grüneisen-Debye formalism, we obtain Grüneisen parameter γ0 = 0.92 ± 0.01 and its volume dependence q = 3.4 ± 0.6. The systematic variation of bulk moduli for several oxide post-perovskites can be described approximately by the relationship K T0 = 5406.0/ V(molar) + 5.9 GPa.

  3. Multi-institutional analysis of bioimpedance spectroscopy in the early detection of breast cancer related lymphedema

    Directory of Open Access Journals (Sweden)

    Vicini FA

    2013-03-01

    Full Text Available Background: The purpose of this study was to evaluate bioelectrical impedance spectroscopy’s (BIS ability to detect and monitor extracellular fluid accumulation of the upper limb as it relates to the extent of loco-regional therapy. Methods: A total of 125 patients with breast cancer from 4 clinical practices were evaluated with BIS at baseline and following loco-regional procedures. In order to assess the ability of BIS to detect subclinical changes by treatment modality, the change in L-Dex score from baseline to measurements taken within 180 days following surgery were calculated. Results: Mean age was 55 years with 68 patients (54.4% undergoing sentinel lymph node (SLN sampling while 57 (45.6% underwent an axillary dissection (ALND. Sixty-five patients (52% underwent radiation therapy (RT. Patients receiving RT had a significantly increased change in L-Dex score (0.8 v.-2.5, p=0.03 compared with those patients not receiving RT. For all patients, ALND was associated with a significantly increased change in L-Dex score (5.0 v. 0.3, p=0.003 compared with SLN. When stratifying by the number of nodes removed, a statistically significant increase in the change in L-Dex score was noted (0.4 v. 0.4 v. 4.3 v. 6.4, p=0.04 for 0-3, 4-6, 7-10 and greater than 10 lymph nodes removed. Conclusions: In this limited analysis, L-Dex scores paralleled the extent of axillary sampling and the addition of radiation therapy; these results demonstrate that BIS can be used to monitor patients for the early onset of edema as differences emerged within 180 days of surgery.

  4. Liver transplantation for patients with hepatocellular carcinoma at the Liver Cancer Institute of Fudan University, China

    Institute of Scientific and Technical Information of China (English)

    ZHOU Jian; HE Yi-feng; YANG Guo-huan; SONG Kang; YUAN Zhou; WANG Yu-qi; TANG Zhao-you; FAN Jia; WU Zhi-quan; QIU Shuang-jian; HUANG Xiao-wu; YU Yao; WANG Zheng; SUN Jian; XIAO Yong-sheng

    2005-01-01

    Background Selection of patients with hepatocellular carcinoma (HCC) for orthotopic liver transplantation (OLT) remains controversial. Since there is a trend to expand the transplant criteria for HCC patients, we reviewed the data of patients with HCC who had received OLT at our institute to determine their survival and prognostic factors.Methods A total of 67 patients with HCC who had undergone OLT from April 2001 through December 2003 were reviewed retrospectively. Selection OLT candidates with HCC was dependent on the anatomical characteristics and/or the severity of underlying liver cirrhosis. The 67 patients were followed up for more than 6 months after transplantation. Their survival rate was calculated by the Kaplan-Meier method. Univariate and multivariate analyses using the Cox proportional hazards regression model were performed to reveal the factors affecting the survival rate.Results No perioperative death occurred in this series. The 1- and 2-year cumulative survival rates were 90.0% and 65.6%, and the disease-free survival (DFS) rates were 77.5% and 62.5% respectively. Univariate analysis revealed the tumor size, portal vein tumor thrombus (PVTT), serum alpha-fetoprotein level, bilobular distribution of tumors, pTNM stage and histological differentiation were statistically significant factors affecting the DFS (P<0.05). Multivariate analysis showed tumor size and PVTT were independent and statistically significant factors affecting the DFS (P=0.005 and 0.010, respectively). In this series, all but 2 received systemic chemotherapy, among them 13 had tumor recurrence within 8 months after OLT.Conclusions OLT is indicated for patients with HCC, even for some patients with end-stage liver disease who may survive longer without tumor recurrence. Adjuvant chemotherapy may decrease the recurrence of HCC after OLT.

  5. The geographical distribution of meteorological parameters associated with high and low summer ozone levels in the lower troposphere and the boundary layer over the eastern Mediterranean (Cairo case)

    OpenAIRE

    Kalabokas, Pavlos D.; Thouret, Valerie; Cammas, Jean-Pierre; Volz-Thomas, Andreas; Boulanger, Damien; Repapis, Christos C.

    2015-01-01

    In continuation of previous research for evaluation of the high ozone levels observed during summer time over the eastern Mediterranean, MOZAIC profiles collected at the airport of Cairo from 1994 to 2008 are analysed. Average profiles corresponding, respectively, to the highest and the lowest ozone mixing ratios for the 0–1.5 km layer over Cairo in summer (JJA) (94 profiles) are examined along with their corresponding composite maps of geopotential height (and anomalies), vertical velocity (...

  6. Risk perception and priority setting for intervention among hepatitis C virus and environmental risks: a cross-sectional survey in the Cairo community.

    OpenAIRE

    Dewedar Sahar; Gad Rita R; Mohamed Mostafa K; Schwarzinger Michaël; Fontanet Arnaud; Carrat Fabrice; Luchini Stéphane

    2010-01-01

    Abstract Background Hepatitis C virus (HCV) recently emerged as a major public health hazard in Egypt. However, dramatic healthcare budget constraints limit access to the costly treatment. We assessed risk perception and priority setting for intervention among HCV, unsafe water, and outdoor air pollution in Cairo city. Methods A survey was conducted in the homes of a representative sample of household heads in Cairo city. Risk perception was assessed using the "psychometric paradigm" where he...

  7. Stereotactic body radiotherapy for localized prostate cancer: Pooled analysis from a multi-institutional consortium of prospective phase II trials

    International Nuclear Information System (INIS)

    Purpose: The effectiveness of stereotactic body radiotherapy (SBRT) for localized prostate cancer is tested. Methods and materials: A total of 1100 patients with clinically localized prostate cancer were enrolled in separate prospective phase 2 clinical trials of SBRT from 8 institutions during 2003–11 and pooled for analysis. SBRT using the CyberKnife delivered a median dose of 36.25 Gy in 4–5 fractions. Patients were low-risk (58%), intermediate-risk (30%) and high-risk (11%). A short-course of androgen deprivation therapy (ADT) was given to 14%. PSA relapse defined as a rise >2 ng/ml above nadir was analyzed with the Kaplan Meier method. Results: With a median follow-up of 36 months there were 49 patients with PSA failure (4.5%), 9 of whom were subsequently determined to be benign PSA bounces. The 5-year biochemical relapse free survival (bRFS) rate was 93% for all patients; 95%, 83% and 78% for GS ⩽6, 7 and ⩾8, respectively (p = 0.001), and 95%, 84% and 81% for low-, intermediate- and high-risk patients, respectively (p 0.2 ng/ml was noted among 16% of patients. For 135 patients possessing a minimum of 5 years follow-up, the 5-year bRFS rate for low- and intermediate-risk patients was 99% and 93%, respectively. Conclusion: PSA relapse-free survival rates after SBRT compare favorably with other definitive treatments for low and intermediate risk patients. The current evidence supports consideration of SBRT among the therapeutic options for these patients

  8. Cancer risk among Italian veterans from the Balkans: the activities of the Italian National Institute of Health

    International Nuclear Information System (INIS)

    In recent years, cases of cancer have been reported among Italian troops involved in the peace-keeping mission in Bosnia and Kosovo. By the end of 2000, the Italian Minister of Defence appointed a Committee of Enquiry to gain a scientifically sound, reliable picture of the health consequences of the exposure of military personnel to Depleted Uranium (DU) and to assess the possible etiologic role DU may have played in the occurrence of specific pathologies. The Committee found a statistically significant excess of Hodgkin's lymphomas, but up to now the lack of thorough knowledge about internal uranium exposure and its potential effects has prevented us from determining whether lymphatic cancers are correlated with DU exposure. The Committee of Enquiry issued several recommendations, in particular: 1) to follow up the cohort of military personnel deployed in Bosnia and Kosovo and monitor the incidence of tumours and the evolution of the ensuing epidemiological scenario, and 2) to list the individuals that could have been exposed to DU for different reasons and enrol them in a long-term programme of medical surveillance. A decision was also made to quantify levels of U and other potentially toxic elements - as well as to measure the isotopic ratio 235U/238U for the assessment of DU - in biological samples of soldiers deployed in war theatres where presumably DU weapons were used, together with tentative indexes of contact with possible genotoxic factors. In this paper a general description is given of the activities carried out by the Italian National Institute of Health (ISS, in the Italian acronym) in compliance with both the recommendations of the Committee of Enquiry and the decision to quantify potential exposures. (author)

  9. Clinical results of stereotactic body radiotherapy for Stage I small-cell lung cancer. A single institutional experience

    International Nuclear Information System (INIS)

    The purpose of this study was to evaluate the treatment outcomes of stereotactic body radiotherapy (SBRT) for Stage I small-cell lung cancer (SCLC). From April 2003 to September 2009, a total of eight patients with Stage I SCLC were treated with SBRT in our institution. In all patients, the lung tumors were proven as SCLC pathologically. The patients' ages were 58-84 years (median: 74). The T-stage of the primary tumor was T1a in two, T1b in two and T2a in four patients. Six of the patients were inoperable because of poor cardiac and/or pulmonary function, and two patients refused surgery. SBRT was given using 7-8 non-coplanar beams with 48 Gy in four fractions. Six of the eight patients received 3-4 cycles of chemotherapy using carboplatin (CBDCA) + etoposide (VP-16) or cisplatin (CDDP) + irinotecan (CPT-11). The follow-up period for all patients was 6-60 months (median: 32). Six patients were still alive without any recurrence. One patient died from this disease and one died from another disease. The overall and disease-specific survival rate at three years was 72% and 86%, respectively. There were no patients with local progression of the lesion targeted by SBRT. Only one patient had nodal recurrence in the mediastinum at 12 months after treatment. The progression-free survival rate was 71%. No Grade 2 or higher SBRT-related toxicities were observed. SBRT plus chemotherapy could be an alternative to surgery with chemotherapy for inoperable patients with Stage I small-cell lung cancer. However, further investigation is needed using a large series of patients. (author)

  10. Clinicopathological analysis of thymic malignancies with a consistent retrospective database in a single institution: from Tokyo Metropolitan Cancer Center

    International Nuclear Information System (INIS)

    Thymic epithelial tumors (TETs), which comprise thymoma and thymic carcinoma, are rare cancers with specific morphological and clinical features. Their clinical characteristics and outcomes have gradually been clarified by assessing large-scale, retrospective data obtained with international cooperation. The study is a retrospective review of 187 Japanese patients with TETs who attended our institution from 1976 to 2012. Relevant clinical features of patients with TETs and their tumors, including histology, staging, treatment strategies, and overall survival, were investigated. Differences in survival were assessed by the Kaplan–Meier method and uni- and multi-variate Cox proportional hazards regression analyses. The 187 patients included 52 patients with stage I, 37 with stage II, 22 with stage III, and 76 with stage IVa/IVb tumors according to the Masaoka–Koga Staging System. As to histological type, five patients had type A, 33 type AB, 19 type B1, 39 type B2, and 15 type B3 thymomas, whereas 68 patients had thymic carcinoma, including 11 with neuroendocrine carcinomas according to the 2004 WHO classification. Either insufficient data were available to classify the tumors of the remaining eight patients or they had rare types. Immunological abnormalities were present in 26 patients, most of whom had thymomas (21.8% of the thymoma group). Most of the patients who presented with symptoms had myasthenia gravis or extensive thymic carcinoma. Secondary cancers were present in 25 patients (13.3%). The overall 5- and 10-year survival rates for thymoma were 85.4 and 71.5%, respectively, and those for thymic carcinoma were 33.8 and 2.3%, respectively. OS differed significantly between stage IVa thymomas and thymic carcinomas. The stage and whether the tumors were thymomas or thymic carcinomas were significant determinants of survival according to multivariate analysis. The efficacy of treatments for thymoma and thymic carcinoma should be investigated separately

  11. Prophylactic cranial irradiation in patients with small-cell lung cancer: the experience at the Institute of Oncology Ljubljana

    International Nuclear Information System (INIS)

    Prophylactic cranial irradiation (PCI) has been used in patients with small-cell lung cancer (SCLC) to reduce the incidence of brain metastases (BM) and thus increase overall survival. The aim of this retrospective study was to analyze the characteristics of patients with SCLC referred to the Institute of Oncology Ljubljana, their eligibility for PCI, patterns of dissemination, and survival. Medical charts of 357 patients with SCLC, referred to the Institute of Oncology Ljubljana between January 2004 and December 2006, were reviewed to determine characteristics of patients chosen for PCI. The following data were collected: age, gender, performance status (PS), extent of the disease, smoking status, type of primary treatment with outcome, haematological and biochemical parameters, PCI use, and finally brain metastases (BM) status at diagnoses and after treatment. PCI was performed in 24 (6.7%) of all patients. Six (25%) patients developed brain metastases after they were treated with PCI. Brain was the only site of metastases in 4 patients, two progressed to multiple organs. Median overall survival of patients with PCI was 21.9 months, without PCI 12.13 months (p = 0.004). From the collected data there were good prognostic factors: age under 65 years, limited disease (LD), performance status, normal levels of lactate dehydrogenase (LDH) and normal levels of C-reactive protein levels (CRP). Other prognostic factors did not show statistical significant values. Survival of patients with LD, who have had PCI, was significantly better than those who had not. We decided to perform PCI in patients with LD, in those with complete or near complete response, and those with good performance status (≥ 80). We did not use PCI in extended disease (ED). The reason for that shall be addressed in the future. Doses for PCI were not uniform, therefore more standard approach should be considered

  12. Impact of institutional experience on survival outcome of patients undergoing combined chemoradiation therapy for inoperable non-small-cell lung cancer

    International Nuclear Information System (INIS)

    Purpose: Clinical experience of both physicians and institutions has been shown to significantly influence the outcome of patients. We conducted this retrospective cohort study to examine its impact on the outcome of patients undergoing combined chemoradiation therapy for the treatment of locally advanced inoperable non-small-cell lung cancer. Methods and Materials: We compared the clinical data from 239 patients who were enrolled in two consecutive Radiation Therapy Oncology Group (RTOG) trials (RTOG 91-06, RTOG 92-04) according to the number of patients enrolled from each institution in either trial alone or the two trials combined. Results: Overall, patients treated at the institutions that enrolled ≥5 patients survived longer than those treated at the institutions that enrolled <5 patients (median survival 20.5 vs. 13.4 months, p=0.0006) with a more than doubling of the 2- and 3-year survival rates (45% and 31% vs. 20% and 13%, respectively). Multivariate analyses confirmed that the number of patients enrolled from each institution was an important prognostic factor for the entire group (p=0.001) and also for RTOG 91-06 (p=0.05) and RTOG 92-04 (p=0.004) when the data were analyzed separately. Conclusion: Institutional experience has a significant impact on the survival outcome of patients undergoing combined chemoradiation therapy for inoperable non-small cell lung cancer

  13. Knowledge and awareness of cervical cancer and its prevention among nursing staff of a tertiary care teaching institute in South India

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    Sneha Badwe Dhodapkar

    2014-08-01

    Full Text Available Background: Cervical cancer is the second leading cause of morbidity and mortality among the females worldwide. India has the highest burden of cervical cancer patients, accounting for approximately one-fifth of the cases in world. Nurses being an important link between the doctors and female patients in OPD or wards, it is imperative that they should be aware of the facts about cervical cancer and especially of screening techniques which can be utilized in low-resource settings. Methods: A cross-sectional interview based study was done among 200 nurses of a tertiary care teaching institute from June 2013 to July 2013, to assess the knowledge and awareness of nursing staff regarding causes of cervical cancer and its prevention and early detection. Results: Among all participated nurses, 85% (n=170 were aware of the term cancer cervix and 45% reported that it is the most frequent gynaecological cancer in India. Only 30.6% reported that it is the leading cause of death among women due to cancer. Young age at first intercourse, multiple sex partners, cigarette smoking, high parity and lower socio-economic status were correctly responded by 13%, 48%, 16%, 9% and 13% of participants respectively, as risk factors for cervical cancer. None of the participants knew about the VIA method of screening for cervical cancer. Among 119 of those participants who knew that cervical cancer can be detected by Pap smear, only 5 (4% had ever undergone Pap smear examination. Conclusions: Nurses identify certain aspects of cervical cancer correctly but their knowledge is not adequate, hence necessary changes should be made in their curriculum. [Int J Reprod Contracept Obstet Gynecol 2014; 3(4.000: 1056-1060

  14. Monitoring of people and workers exposure to the electric, magnetic and electromagnetic fields in an Italian national cancer Institute

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    Palomba Raffaele

    2008-07-01

    Full Text Available Abstract Background The paper reports the electric, magnetic and electromagnetic fields (emf measurements carried out in the Regina Elena National Cancer Institute (NCI. Several devices, used in diagnostics and in medical cures, can represent sources of emf for the workers and for the public subjected to the treatments. The aim is to evaluate their exposition, in order to assess the compliance with the law. Methods The investigations have been carried out in the departments of: intensive care, physiotherapy, MR presstherapy and in the surgical rooms. The measurements have been performed using broad band probes in the frequency ranges 5 Hz÷30 kHz and 100 kHz-3 GHz. Results The variability of the magnetic induction (B(μT levels is between 0,05 μT and 80 μT. The statistical distribution shows that most of the measurements are in the range 0,05 Conclusion The measurement of the emf levels in the NCI is recommended because of the presence of the oncological patients; their long stay near the equipments and their day-long exposure represent additional risk factors for which a prudent avoidance strategy have to de adopted.

  15. Web services-based access to local clinical trial databases: a standards initiative of the Association of American Cancer Institutes.

    Science.gov (United States)

    Stahl, Douglas C; Evans, Richard M; Afrin, Lawrence B; DeTeresa, Richard M; Ko, Dave; Mitchell, Kevin

    2003-01-01

    Electronic discovery of the clinical trials being performed at a specific research center is a challenging task, which presently requires manual review of the center's locally maintained databases or web pages of protocol listings. Near real-time automated discovery of available trials would increase the efficiency and effectiveness of clinical trial searching, and would facilitate the development of new services for information providers and consumers. Automated discovery efforts to date have been hindered by issues such as disparate database schemas, vocabularies, and insufficient standards for easy intersystem exchange of high-level data, but adequate infrastructure now exists that make possible the development of applications for near real-time automated discovery of trials. This paper describes the current state (design and implementation) of the Web Services Specification for Publication and Discovery of Clinical Trials as developed by the Technology Task Force of the Association of American Cancer Institutes. The paper then briefly discusses a prototype web service-based application that implements the specification. Directions for evolution of this specification are also discussed. PMID:14728248

  16. Adjuvant radiotherapy after prostatectomy for prostate cancer in Japan. A multi-institutional survey study of the JROSG

    International Nuclear Information System (INIS)

    In Japan, the use of adjuvant radiotherapy after prostatectomy for prostate cancer has not increased compared with the use of salvage radiotherapy. We retrospectively evaluated the outcome of adjuvant radiotherapy together with prognostic factors of outcome in Japan. Between 2005 and 2007, a total of 87 patients were referred for adjuvant radiotherapy in 23 institutions [median age: 64 years (54–77 years), median initial prostate-specific antigen: 11.0 ng/ml (2.9–284 ng/ml), Gleason score (GS): 6, 7, 8, 9, 10 = 13.8, 35.6, 23.0, 27.6, 0%, respectively]. Rates of positive marginal status, seminal vesicle invasion (SVI) and extra-prostatic extension (EPE) were 74%, 26% and 64%, respectively. Median post-operative PSA nadir: 0.167 ng/ml (0–2.51 ng/ml). Median time from surgery to radiotherapy was 3 months (1–6 months). A total dose of ≥60 Gy and 0.2 (P=0.02), and tended to be more favorable after radiotherapy ≤3 months from surgery than >3 months from surgery (P=0.069). Multivariate analysis identified SVI and post-operative PSA nadir as independent prognostic factors for bRFS (P=0.001 and 0.018, respectively). (author)

  17. ONE STEP NUCLEIC ACID AMPLIFICATION IN BREAST CANCER SENTINEL LYMPH NODE.A SINGLE INSTITUTIONAL EXPERIENCE AND A SHORT REVIEW.

    Directory of Open Access Journals (Sweden)

    Tatiana eBrambilla

    2015-06-01

    Full Text Available Sentinel lymph node (SLN examination is a standard in breast cancer patients, with several methods employed along its 20-years history, the last one represented by OSNA. The latter is a intra-operative molecular assay searching for CK19 mRNA as a surrogate of metastatic cells. Our 3-years experience with OSNA (1122 patients showed results overlapping those recorded in the same Institution with a morphological evaluation (930 patients of SLN. In detail the data of OSNA were almost identical to those observed with standard post-operative procedure in terms of patients with positive SLN (30% and micrometastatic/macrometastatic involvement of SLN (respectively 38-45% and 62-55%. By contrast when OSNA was compared to the standard intra-operatory procedure it was superior in terms of accuracy, prompting the use of this molecular assay as a very valid and reproducible for intra-operative evaluation of SLN.Further possibilities prompting the use of OSNA range from adhesion to quality control programs, saving of medical time, ability to predict, during surgery, additional nodal metatastis and molecular bio-banking.

  18. 75 FR 71134 - National Institutes of Health

    Science.gov (United States)

    2010-11-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Closed Meeting..., Cancer Control, National Institutes of Health, HHS) Dated: November 16, 2010. Jennifer S....

  19. Epidemiological Study Of Risky Behaviours And Their Relation With Mental Ill Health Among Secondary School Students In Cairo

    OpenAIRE

    Essam A. El-Moselhy; Morsy A. Ammar; Khaled M. Abd-Allah; Ibrahim A.

    2005-01-01

    A cross-sectional design was carried out on 827 students from general and technical secondary schools in Cairo. The aim of this study was to determine the prevalence of risky behaviours among the studied students, to assess their relation with sociodemographic factors and psychological problems and to explore student's attitude toward these behaviours. The data were collected by a standardized interviewing form. Different psychological symptoms were assessed using Middle Sex Hospital Question...

  20. Lattice preferred orientation in CaIrO3 perovskite and post-perovskite formed by plastic deformation under pressure

    Science.gov (United States)

    Niwa, Ken; Yagi, Takehiko; Ohgushi, Kenya; Merkel, Sébastien; Miyajima, Nobuyoshi; Kikegawa, Takumi

    2007-11-01

    Lattice preferred orientations (LPO) developed in perovskite and post-perovskite structured CaIrO3 were studied using the radial X-ray diffraction technique combined with a diamond anvil cell. Starting materials of each phase were deformed from 0.1 MPa to 6 GPa at room temperature. Only weak LPO was formed in the perovskite phase, whereas strong LPO was formed in the post-perovskite phase with an alignment of the (010) plane perpendicular to the compression axis. The present result suggests that the (010) is a dominant slip plane in the post-perovskite phase and it is in good agreement with the crystallographic prediction, dislocation observations via transmission electron microscopy, and a recent result of simple shear deformation experiment at 1 GPa 1,173 K. However, the present result contrasts markedly from the results on MgGeO3 and (Mg,Fe)SiO3, which suggested that the (100) or (110) is a dominant slip plane with respect to the post-perovskite structure. Therefore it is difficult to discuss the behavior of the post-perovskite phase in the Earth’s deep interior based on existing data of MgGeO3, (Mg,Fe)SiO3 and CaIrO3. The possible sources of the differences between MgGeO3, (Mg,Fe)SiO3 and CaIrO3 are discussed.

  1. Post-perovskite CaIrO3: A j=1/2 quasi-one-dimensional antiferromagnet

    Science.gov (United States)

    Bogdanov, Nikolay A.; Katukuri, Vamshi M.; Stoll, Hermann; van den Brink, Jeroen; Hozoi, Liviu

    2012-06-01

    The 5d5 iridate CaIrO3 is isostructural with the post-perovskite phase of MgSiO3, recently shown to occur under extreme pressure in the lower Earth's mantle. It therefore serves as an analog of post-perovskite MgSiO3 for a wide variety of measurements at ambient conditions or achievable with conventional multianvile pressure modules. By multireference configuration-interaction calculations we here provide essential information on the chemical bonding and magnetic interactions in CaIrO3. We predict a large antiferromagnetic superexchange of 120 meV along the c axis, the same size with the interactions in the cuprate superconductors, and ferromagnetic couplings smaller by an order of magnitude along a. CaIrO3 can thus be regarded as a j=1/2 quasi-one-dimensional antiferromagnet. While this qualitatively agrees with the stripy magnetic structure proposed by resonant x-ray diffraction, the detailed microscopic picture emerging from our study, in particular, the highly uneven admixture of t2g components, provides a clear prediction for resonant inelastic x-ray scattering experiments.

  2. Unusual ferromagnetism and strong spin-orbit coupling in Post-Perovskite CaIrO3

    Science.gov (United States)

    Marshall, Luke; Cheng, Jinguang; Zhou, Jianshi; Goodenough, John B.; Haskel, Daniel; van Veenendaal, Michel

    2012-02-01

    Strong spin-orbit coupling (SOC) and strong correlations have been considered essential in understanding the unusual physical properties of the 4d and 5d transition-metal oxides, such as the SOC driven Mott insulating state in Sr2IrO4. Recently, an unusual atomic-like orbital moment and strong SOC have been confirmed experimentally in 9R-BaIrO3 through analysis of the branching ratio at the Ir L2,3 absorption edges as obtained from x-ray absorption and x-ray magnetic circular dichroism (XMCD) measurements. We have applied the same techniques to probe unusual ferromagnetism and SOC in the post-perovskite (pPv) CaIrO3, which is an insulator and exhibits weak ferromagnetism below TC 110K. The branching ratio at the Ir L2,3 absorption edges, which is close to unity in pPv CaIrO3, appears to indicate an even stronger spin-orbit interaction in the pPv CaIrO3 than in 9R-BaIrO3. However, it has been challenging to model the Ir 5d orbital moment, as probed by the XMCD measurements, due to the understood local octahedral-site distortions.

  3. Comparison of the epidemiologic features and patterns of initial care for prostate cancer between public and private institutions: a survey by the Brazilian Society of Urology

    Directory of Open Access Journals (Sweden)

    Aguinaldo Cesar Nardi

    2012-04-01

    Full Text Available OBJECTIVE: To describe the epidemiological features and patterns of initial care for prostate cancer at public and private institutions in the State of Sao Paulo, Brazil. MATERIALS AND METHODS: A total of 1,082 physicians affiliated to the Sao Paulo Section of the Brazilian Society of Urology were invited to participate in this cross-sectional, web-based survey. Between September 2004 and September 2005, participating urologists entered data on demographic, clinical and pathological characteristics of patients diagnosed with prostate cancer in their practice. Data on patients attended at public institutions were analyzed and compared with those patients attended at private practice. RESULTS: One hundred and ten society members contributed with data from 1915 patients, 1026 (53.6% of whom from public institutions. When compared with patients attended at private institutions, those attended at public institutions were older and more likely to be black, had higher serum prostate specific antigen (PSA levels, had a higher probability of being diagnosed with metastatic disease, but were less likely to undergo prostatectomy (all P < 0.001. In multivariate analysis, age, biopsy Gleason score, and being attended at a public institution were independently associated with metastatic disease upon diagnosis. The significant predictors of nonsurgical treatment were age, black race, and higher serum levels of PSA. CONCLUSIONS: A statewide registry provides valuable information regarding patient demographics, clinical features, and patterns of care. The results of this study suggest that significant disparities exist for patients with prostate cancer attended at different health-care systems. The relative contribution of biological versus socioeconomic features remains uncertain.

  4. Report of National Cancer Institute symposium: comparison of mechanisms of carcinogenesis by radiation and chemical agents. II. Cellular and animal models

    International Nuclear Information System (INIS)

    This segment of the report of the proceedings of the National Cancer Institute symposium is devoted to the presentations about studies with in vitro cell systems, in vitro-in vivo systems, and whole animals including humans. The NCI symposium was designed to cover many aspects of carcinogenesis so that the similarities and differences of the manner in which ionizing radiation and chemical carcinogens initiate cancer and complete its expression could be examined. The hope was that the identification of both the common and the clearly distinct features would help elucidate mechanisms and indicate areas for new research

  5. Genotypic, physiological, and biochemical characterization of potentially pathogenic Acanthamoeba isolated from the environment in Cairo, Egypt.

    Science.gov (United States)

    Tawfeek, Gihan Mostafa; Bishara, Sawsan Abdel-Hamid; Sarhan, Rania Mohammad; ElShabrawi Taher, Eman; ElSaady Khayyal, Amira

    2016-05-01

    Acanthamoebae are the most common opportunistic amphizoic protozoa that cause life-threatening granulomatous amoebic encephalitis in immunocompromised individuals and sight-threatening amoebic keratitis (AK) in contact lens wearers. The present work aimed to determine the presence of Acanthamoeba isolates in different environmental sources: water, soil, and dust in Cairo, Egypt and to characterize the pathogenic potential of the isolated Acanthamoeba using physiological and biochemical assays as well as determination of the genotypes in an attempt to correlate pathogenicity with certain genotypes. The study included the collection of 22 corneal scrapings from patients complaining of symptoms and signs indicative of acanthamoeba keratitis (AK) and 75 environmental samples followed by cultivation on non-nutrient agar plates preseeded with E. coli. Positive samples for Acanthamoeba were subjected to osmo- and thermo-tolerance assays and zymography analysis. Potentially pathogenic isolates were subjected to PCR amplification using genus-specific primer pair. Isolates were classified at the genotype level based on the sequence analysis of Acanthamoeba 18S rRNA gene (diagnostic fragment 3). The total detection rate for Acanthamoeba in environmental samples was 33.3 %, 31.4 % in water, 40 % in soil, and 20 % in dust samples. Three and two Acanthamoeba isolates from water and soil sources, respectively, had the potential for pathogenicity as they exhibited full range of pathogenic traits. Other 12 isolates were designated as weak potential pathogens. Only ten of the environmental isolates were positive in PCR and were classified by genotype analysis into T4 genotype (70 %), T3 (10 %) and T5 (20 %). Potential pathogens belonged to genotypes T4 (from water) and T5 (from soil) while weak potential pathogens belonged to genotypes T3 (from water) and T4 (from water and soil). Additionally, T7 genotype was isolated from keratitis patients. There is a considerable

  6. A single-institution experience with bevacizumab in the treatment of metastatic colorectal cancer and in conjunction with liver resection

    Directory of Open Access Journals (Sweden)

    Osterlund P

    2014-07-01

    Full Text Available Pia Osterlund,1,2 Reetta Peltonen,2,3 Tuomo Alanko,1 Petri Bono,1,2 Helena Isoniemi2,3 1Department of Oncology, Helsinki University Central Hospital, Helsinki, 2Institute of Clinical Medicine, University of Helsinki, Helsinki, 3Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland Background: Bevacizumab is active in the treatment of metastatic colorectal cancer (mCRC. However, efficacy of bevacizumab has predominantly been evaluated on selected patients with relatively good performance status and minor comorbidities. We evaluated the efficacy and safety of bevacizumab in unselected patients with mCRC, some of whom underwent liver resection. Material and methods: All patients with inoperable mCRC, fit for combination chemotherapy (n=180, who were initially not resectable, not included into studies and without contraindications to bevacizumab, and initiated on bevacizumab at the Helsinki University Central Hospital between April 2004 and December 2005 were included (n=114. Most (n=70 received 5-fluorouracil/leucovorin/irinotecan plus bevacizumab as first-line therapy. The remainder (n=44 of the patients received bevacizumab in combination with oxaliplatin or irinotecan with or without 5-fluorouracil or capecitabine. Minimum follow-up was 7 years. Treatment response was evaluated every 8–10 weeks according to RECIST criteria. Results: Median age was 59.6 years (range 35–79; male/female ratio was 54%/46%; World Health Organization performance status 0/1/2–3 was 33%/55%/11%, respectively; and the number of metastatic sites, one/two/three or more, was 31%/21%/48%, respectively. Median duration of bevacizumab therapy was 7.8 months (range 0.5–70.5 with pauses. In first-line (n=40, response rate (RR was 62%, progression-free survival (PFS 11.7 months, and overall survival (OS 22.1 months. In second-line (n=43, RR was 44%, PFS 8.7 months, and OS 18.7 months. In later lines (n=31, RR was 14%, PFS 6.7 months, and OS 14

  7. Cancer of Oral Cavity Abutting the Mandible; Predictors of Loco-regional Failure

    International Nuclear Information System (INIS)

    The purpose of this study is to analyze the causes of Loco-regional failure in 51 patients with tumors of the oral cavity abutting the mandible. Patients and Methods: This cross-sectional study (27 patients were operated upon in the retrospective section and 24 patients in the prospective section of the study) was done in the department of Surgical Oncology, National Cancer Institute, Cairo University, from January 2003 to January 2008. Fifty-one patients, with oral cavity cancerous lesions abutting the mandible, were operated upon by segmental mandibulectomy en-bloc with primary tumor resection in addition to modified radical or selective neck dissection according to the status of the cervical lymph nodes. Results: During a median follow-up of 2 years, 29 patients (56.8%) had local recurrences, the incidence of nodal recurrence after neck dissection was detected in 4 patients (7.8%). On multivariate analysis, tumor depth, tumor grade, oral mucosa, soft tissue and bone surgical margins in addition to metastatic lymphadenopathy were independent prognostic factors of loco-regional failure and disease-free survival. Conclusion: Oral cavity cancers abutting the mandible should be treated with great caution by a multidisciplinary oncology team (resection and reconstruction surgeons) as it has a very aggressive biologic behavior. Negative intraoperative pathological margins should be attempted since this is the critical point for patients with cancers abutting the mandible? Further research on the biologic margin and genetic study is required

  8. National Cancer Institute News

    Science.gov (United States)

    ... and Foundation Medicine, Inc. (FMI), a molecular information company. Newly launched Genomic Data Commons to facilitate data ... of Health FOLLOW US Facebook Twitter Instagram YouTube Google+ LinkedIn GovDelivery RSS CONTACT INFORMATION Contact Us LiveHelp ...

  9. Primary non-Hodgkin's lymphomas of the breast: 23 years of experience at the Colombian national cancer institute

    International Nuclear Information System (INIS)

    Primary non- Hodgkin's lymphomas of the breast (PNHLB) are an infrequent malignancy. In a review of the literature, in which six Latin American journals are included, approximately 450 cases have been reported during the past two decades. in this paper we present the experience of the national cancer institute of Colombia during the last 23 years. Objective: to carry out a retrospective analysis of the characteristics, natural history, prognostic factors, and outcome of patients with PNHLB at the NCI of Colombia. Methods: the medical histories of patients diagnosed with PNHLB between 1980 and 2003 were reviewed; likewise, the clinical characteristics, treatment protocols, and final outcomes were analyzed. Results: 25 patients were identified as PNHLB. The average follow-up was 57 months. The medium age was 58, ranging from 26 to 83. 84% had diffused large cell lymphoma. The Karnofsky index was over 80 in 92% of the patients. 72% received chop chemotherapy. Two patients received a combination without doxorubicin. 68% received combined chemo- and radiation therapy. Two patients refused therapy. Two patients died before receiving any type of treatment. CNS compromise was observed in 20% of patients during the evolution of their disease. The youngest patient, whose case deserves special comment, obtained a second complete remission with simple mastectomy, after having relapsed after conventional chemotherapy, radiotherapy, and autologous bone marrow transplant. No significant prognostic variables were found using the univariate analysis. Conclusions: a high rate of complete remission can be achieved by using combined treatment in patients with PNHLB. The medium overall survival was not reached after 71 months of follow-up. The most frequent relapse site was the CNS

  10. Brachytherapy for T1-T2 floor-of-the-mouth cancers: the Gustave-Roussy Institute experience

    International Nuclear Information System (INIS)

    Purpose: In a retrospective analysis, we evaluated the Gustave-Roussy Institute's experience of locoregional control, survival, and complications of low-dose rate brachytherapy for carcinoma of the floor of the mouth. Methods and Materials: Between 1970 and 1985, 160 patients with previously untreated carcinoma of the floor of the mouth received interstitial brachytherapy as definitive treatment. Of the 160 patients, 79 (49%) had T1 and 81 (51%) had T2 lesions, and 127 (79%) had N0 and 33 (21%) had N1; 84% of tumors arose from the anterior floor of the mouth. Brachytherapy was performed with 192Ir wires, according to the Paris system rules, followed by neck dissection (T2 or N1) or follow-up (T1N0). Results: With a follow-up period of 9-19 years, the observed survival rates were 89% at 2 years and 76% at 5 years, and the local control rates were 93% in T1 and 88% in T2 tumors. A low rate of distant metastases was noticed (5%); 31% of patients developed a second primary cancer. Severe mucosal necrosis was observed in <10% of patients. Any grade of bone necrosis was seen in 18% of cases (only 2.5% had G3 necrosis). This complication occurred more frequently in patients with poor dental status and in those treated without dental protection during implantation (p <0.001). Conclusion: Radical brachytherapy offers excellent local control (89%) and an acceptable rate of complications (<10% severe necrosis) that may be significantly decreased with dental care and the use of protective devices. The high incidence of second malignancies remains a major concern in these patients

  11. The single institutional outcome of postoperative radiotherapy and concurrent chemoradiotherapy in resected non-small cell lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hyo Chun; Kim, Yeon Si; Oh, Se Jin; Lee, Yun Hee; Lee, Dong Soo; Song, Jin Ho; Kang, Jin Hyung; Park, Jae Ki [Seoul St. Mary' s Hospital, The Catholic University of Korea College of Medicine, Seoul (Korea, Republic of)

    2014-09-15

    This study was conducted to observe the outcomes of postoperative radiotherapy (PORT) with or without concurrent chemotherapy in resected non-small cell lung cancer (NSCLC) in single institution. From 2002 to 2013, 78 patients diagnosed with NSCLC after curative resection were treated with radiotherapy alone (RT, n = 48) or concurrent chemoradiation (CCRT, n = 30). The indications of adjuvant radiation therapy were N2 node positive (n = 31), close or involved resection margin (n = 28), or gross residual disease due to incomplete resection (n = 19). The median radiation dose was 57.6 Gy (range, 29.9 to 66 Gy). Median survival time was 33.7 months (range, 4.4 to 140.3 months). The 5-year overall survival (OS) rate was 49.5% (RT 46% vs. CCRT 55.2%; p = 0.731). The 3-year disease-free survival rate was 45.5% (RT 39.4% vs. CCRT 55.3%; p = 0.130). The 3-year local control rate was 68.1% (RT 64.4% vs. CCRT 77.7%; p = 0.165). The 3-year DMFS rate was 56.1% (RT 52.6% vs. CCRT 61.7%; p = 0.314). In multivariate analysis, age > or =66 years and pathologic stage III were significant poor prognostic factors for OS. Treatment failure occurred in 40 patients. Four patients had radiologically confirmed grade 3 radiation pneumonitis. In NSCLC, adjuvant RT or CCRT after curative surgery is a safe and feasible modality of treatment. OS gain was seen in patients less than 66 years. Postoperative CCRT showed a propensity of achieving better local control and improved disease-free survival compared to RT alone according to our data.

  12. Can concomitant-boost accelerated radiotherapy be adopted as routine treatment for head-and-neck cancers? A 10-year single-institution experience

    OpenAIRE

    Allal, Abdelkarim Said; Taussky, Daniel; Mach, Nicolas; Becker, Minerva; Bieri, Sabine; Dulguerov, Pavel

    2004-01-01

    Accelerated schedules are effective in overcoming repopulation during radiotherapy (RT) for head-and-neck cancers, but their feasibility is compromised by increased toxicity. The therapeutic ratio may be particularly favorable for 5-week regimens. This study reports the 10-year experience of a single institution in the routine use of concomitant boost RT as standard radical treatment in all but the most favorable stage patients.

  13. Challenges in converting an interviewer-administered food probe database to self-administration in the National Cancer Institute Automated Self-administered 24-Hour Recall (ASA24)

    OpenAIRE

    Zimmerman, Thea Palmer; Hull, Stephen G.; McNutt, Suzanne; Mittl, Beth; Islam, Noemi; Guenther, Patricia M.; Thompson, Frances E; Potischman, Nancy A.; Subar, Amy F.

    2009-01-01

    The National Cancer Institute (NCI) is developing an automated, self-administered 24-hour dietary recall (ASA24) application to collect and code dietary intake data. The goal of the ASA24 development is to create a web-based dietary interview based on the US Department of Agriculture (USDA) Automated Multiple Pass Method (AMPM) instrument currently used in the National Health and Nutrition Examination Survey (NHANES). The ASA24 food list, detail probes, and portion probes were drawn from the ...

  14. Persistent semi-metal-like nature of epitaxial perovskite CaIrO3 thin films

    Science.gov (United States)

    Biswas, Abhijit; Jeong, Yoon Hee

    2015-05-01

    Strong spin-orbit coupled 5d transition metal based ABO3 oxides, especially iridates, allow tuning parameters in the phase diagram and may demonstrate important functionalities, for example, by means of strain effects and symmetry-breaking, because of the interplay between the Coulomb interactions and strong spin-orbit coupling. Here, we have epitaxially stabilized high quality thin films of perovskite (Pv) CaIrO3. Film on the best lattice-matched substrate shows semi-metal-like characteristics. Intriguingly, imposing tensile or compressive strain on the film by altering the underlying lattice-mismatched substrates still maintains semi-metallicity with minute modification of the effective correlation as tensile (compressive) strain results in tiny increases (decreases) of the electronic bandwidth. In addition, magnetoresistance remains positive with a quadratic field dependence. This persistent semi-metal-like nature of Pv-CaIrO3 thin films with minute changes in the effective correlation by strain may provide new wisdom into strong spin-orbit coupled 5d based oxide physics.

  15. Assessment of groundwater quality using geographical information system (GIS), at north-east Cairo, Egypt.

    Science.gov (United States)

    El-Shahat, M F; Sadek, M A; Mostafa, W M; Hagagg, K H

    2016-04-01

    The present investigation has been conducted to delineate the hydrogeochemical and environmental factors that control the water quality of the groundwater resources in the north-east of Cairo. A complementary approach based on hydrogeochemistry and a geographical information system (GIS) based protectability index has been employed for conducting this work. The results from the chemical analysis revealed that the groundwater of the Quaternary aquifer is less saline than that of the Miocene aquifer and the main factors that control the groundwater salinity in the studied area are primarily related to the genesis of the original recharging water modified after by leaching, dissolution, cation exchange, and fertilizer leachate. The computed groundwater quality index (WQI) falls into two categories: fair for almost all the Miocene groundwater samples, while the Quaternary groundwater samples are all have a good quality. The retarded flow and non-replenishment of the Miocene aquifer compared to the renewable active recharge of the Quaternary aquifer can explain this variation of WQI. The index and overlay approach exemplified by the DUPIT index has been used to investigate the protectability of the study aquifers against diffuse pollutants. Three categories (highly protectable less vulnerable, moderately protectable moderately vulnerable and less protectable highly vulnerable) have been determined and areally mapped. PMID:27105417

  16. A five-year analysis of the incidence of glomerulonephritis at Cairo University Hospital-Egypt

    Directory of Open Access Journals (Sweden)

    Salwa Ibrahim

    2012-01-01

    Full Text Available Our study aimed to obtain a comprehensive review of the incidence of biopsy-proven glomerulonephritis (GN at the Cairo University Hospitals, Egypt, over the last five years. We analyzed the clinical and pathological data of all renal biopsy samples that were performed during the period from July 2003 to July 2008. Renal biopsy samples of 924 patients were referred for pathological assessment during the period of the study [437 male and 487 female patients; their mean age was 26.5 ± 14.6 years (range: 2.5-71 years]. Focal segmental glomerulo-nephritis was the most frequent cause of primary GN (21.21%, followed by mesangial proliferative GN (18.93%, diffuse proliferative GN (13.96%, focal proliferative GN (12.77% and membranous GN (10.93%. The results could be explained by the high incidence of lupus nephritis among the study subjects as well as the relatively young age of the study group.

  17. Grouting of Multiple Leaf-Masonry Walls: Application on Some Islamic Historical Monuments in Cairo, Egypt

    Directory of Open Access Journals (Sweden)

    Sayed HEMEDA

    2012-12-01

    Full Text Available Present study summarizes an overview on the available experimental and practical data and results from laboratory testing (ungrouted and grouted three leaf masonry wallettes in compression and in diagonal compression. On the basis of the experimental results, (A the structural behavior of the multiple leaf-masonry walls studied in details (b the parameters that affect the behavior of ungrouted masonry are detected and commented upon, and (c the behavior of grouted masonry studied in details. Particularly attention to be paid to large walls whose construction may comprise different kinds of materials. Such walls include cavity walls; rubble filled masonry walls and veneered brick walls which have poor quality core. Not only may the interior of the wall be less capable of carrying load but movement of the core material may also be a source of new stresses. As the experimental results show that the key parameter for the improvement of the mechanical properties of masonry is not the compressive strength of the injected grout, emphasis is given to ternary, as well as to hydraulic lime based grouts: those materials are expected to ensure durable interventions, they lead to a significant enhancement of the mechanical properties of masonry. On the basis of the experimental data on wallettes, as well as based on recent data from tests on grouted cylinders made of filling materials, simple formulae are drived, allowing for the strength of masonry to be calculated, and scientifically interventions processes and techniques had been applied to selected historical monuments in Cairo.

  18. Knowledge and attitude towards cervical cancer screening among female students and staff in a tertiary institution in the Niger Delta

    Directory of Open Access Journals (Sweden)

    Owoeye I.O.G

    2013-01-01

    Full Text Available Background: Cervical cancer is a largely preventable disease. In western countries, the incidence of and mortality associated with cervical cancer has reduced substantially following the introduction of effective cervical screening programmes. This is in contrast to what is obtained in Africa including Nigeria where cervical screening is rudimentary or non- existent. Aim: This study seeks to assess the knowledge, level of perception and the attitude of female staff and students of Niger Delta University, Nigeria, towards cervical cancer screening. Methods: A questionnaire was used for data collection. The questions were made to capture the objectives of the study. Results: Most of the respondents 278 (72% were aware of cervical cancer, while only 182 (50.6% were aware of cervical cancer screening. Pap smear was the most popular screening test mentioned by respondents 100 (41.2%, while some respondents (8.5% of staff and 16.3% of students wrongly believed that blood test is used for cervical cancer screening. There is a significant association between awareness and practice of cervical cancer screening amongst staff and students (X2 = 29.4, P=0.00. Conclusion: The study shows that awareness of cervical cancer screening was higher amongst students than staff of Niger Delta University. Uptake was low in both staff and students. There was an association between awareness and practice of cervical cancer screening amongst respondents. Overall, a greater proportion of the staff respondents had little or no knowledge of cervical cancer screening.

  19. Using Large Institutional or National Databases to Evaluate Prostate Cancer Outcomes and Patterns of Care: Possibilities and Limitations

    OpenAIRE

    Daniel Su; Jang, Thomas L.

    2011-01-01

    Prostate cancer is the most common non–skin-related cancer in men. With advances in technology, the care and treatment for men with this disease continues to become more complex. Large databases offer researchers a unique opportunity to conduct prostate cancer research in various areas, and provide important information that helps patients and providers determine prognosis after treatment. Furthermore, the studies using these databases may provide information on how side effects from various ...

  20. Treatment and prognosis of cervical cancer associated with pregnancy: analysis of 20 cases from a Chinese tumor institution

    OpenAIRE

    Zhang, Xiang; Gao, Yong-liang; Yang, Yue

    2015-01-01

    This study was designed to investigate the therapeutic approaches and prognosis for cervical cancer associated with pregnancy. Clinical information, therapeutic strategies, and follow-up results of 20 patients with cervical cancer associated with pregnancy from Jan. 2000 to June 2009 in the Zhejiang Cancer Hospital were retrospectively analyzed. The International Federation of Gynecology and Obstetrics (FIGO) stages were: in situ (n=1), stage IA1 (n=1), stage IB1 (n=5), stage IB2 (n=1), stage...

  1. Long-Term Survival and Local Relapse Following Surgery Without Radiotherapy for Locally Advanced Upper Rectal Cancer: An International Multi-Institutional Study.

    Science.gov (United States)

    Park, Jun Seok; Sakai, Yoshiharu; Simon, Ng Siu Man; Law, Wai Lun; Kim, Hyeong Rok; Oh, Jae Hwan; Shan, Hester Cheung Yui; Kwak, Sang Gyu; Choi, Gyu-Seog

    2016-05-01

    Controversy remains regarding whether preoperative chemoradiation protocol should be applied uniformly to all rectal cancer patients regardless of tumor height. This pooled analysis was designed to evaluate whether preoperative chemoradiation can be safely omitted in higher rectal cancer.An international consortium of 7 institutions was established. A review of the database that was collected from January 2004 to May 2008 identified a series of 2102 patients with stage II/III rectal or sigmoid cancer (control arm) without concurrent chemoradiation. Data regarding patient demographics, recurrence pattern, and oncological outcomes were analyzed. The primary end point was the 5-year local recurrence rate.The local relapse rate of the sigmoid colon cancer (SC) and upper rectal cancer (UR) cohorts was significantly lower than that of the mid/low rectal cancer group (M-LR), with 5-year estimates of 2.5% for the SC group, 3.5% for the UR group, and 11.1% for the M-LR group, respectively. A multivariate analysis showed that tumor depth, nodal metastasis, venous invasion, and lower tumor level were strongly associated with local recurrence. The cumulative incidence rate of local failure was 90.6%, 92.5%, and 94.4% for tumors located within 5, 7, and 9 cm from the anal verge, respectively.Routine use of preoperative chemoradiation for stage II/III rectal tumors located more than 8 to 9 cm above the anal verge would be excessive. The integration of a more individualized approach focused on systemic control is warranted to improve survival in patients with upper rectal cancer. PMID:27258487

  2. Robert Clarke Named as the National Cancer Institute - Sigma Xi Distinguished Lecturer for 2012-2013 — Site

    Science.gov (United States)

    Dr. Clarke is an expert on the effects of hormones and growth factors on breast cancer. He and his laboratory are actively pursuing the cellular and molecular mechanisms responsible for the emergence of resistance in breast cancer cells to endocrine and cytotoxic therapies.

  3. Geomechanical Investigations for Architectural Heritage Preservation. The Habib Sakakini Palace in Cairo, Egypt

    Directory of Open Access Journals (Sweden)

    Sayed HEMEDA

    2013-03-01

    Full Text Available The understanding of the geotechnical problems and failure mechanisms of stone structures of Sakakini palace (1897 AC entails a comprehensive study on the mechanical behavior of the stones and other construction materials. In addition to micro analysis, geological and geomorphologic interests, several investigations on stone deterioration and engineering geology were performed. First phase included more advanced techniques, which provided additional information on particular aspects of site deterioration and it included laser analysis (LIBS, electron probe micro analysis, micro XRD and XRF analyses, scanning electron microscope analysis coupled with EDX probing, transmission electron microscopy and grain size distribution analysis, permeability and pore size distribution of stone, mortars, core binders and other construction materials. Second phase included the determination of mechanical properties of building stones, such as compressive strength, modulus of elasticity, tensile strength, and shear strength. To obtain reliable values for these properties, a suitable number of samples should be extracted, prepared for testing, and properly tested. The test results are then analyzed to establish the investigated stone properties. The testing program includes extracting seven cylindrical cores from the basement stone walls of Sakakini’s mansion in down town Cairo. The objectives of the study are to provide a characterization of micro structures and the mechanical properties of the stones of Sakakini’s Mansion; The purpose of the present research is to provide recommendations regarding the strengthening and the safety of architectural heritage under long and short-term loading. For this purpose, a set of experimental tests and of advanced numerical analyses are to be carried out.

  4. LAI based trees selection for mid latitude urban developments: A microclimatic study in Cairo, Egypt

    Energy Technology Data Exchange (ETDEWEB)

    Fahmy, Mohamad [School of Architecture, University of Sheffield, Sheffield (United Kingdom); Department of Architecture, Military Technical College, Cairo (Egypt); Sharples, Stephen [School of Architecture, University of Sheffield, Sheffield (United Kingdom); Yahiya, Mahmoud [Department of Mechanical Engineering, University of Sheffield, Sheffield (United Kingdom); Mechanical Engineering Branch, Military Technical College, Cairo (Egypt)

    2010-02-15

    To study the leaf area index, LAI, based thermal performance in distinguishing trees for Cairo's urban developments, ENVI-met plants database was used as platform for a foliage modeling parameter, the leaf area density, LAD. Two Egyptian trees; Ficus elastica, and Peltophorum pterocarpum were simulated in 2 urban sites with one having no trees, whilst the second is having Ficus nitida trees. Trees LAD values were calculated using flat leaves' trees LAI definition to produce maximum ground solid shadow at peak time. An empirical value of 1 for LAI is applied to numerically introduce LAD values for ENVI-met. Basically, different meteorological records showed improvements for pedestrian comfort and ambient microclimate of the building using F. elastica. About 40-50% interception of direct radiation, reductions in surfaces' fluxes around trees and in radiant temperature T{sub mrt} in comparison to base cases gave preferability to F. elastica. The lack of soil water prevented evapotranspiration to take place effectively and the reduced wind speeds concluded negligible air temperature differences from both base cases except slightly appeared with the F. elastica. Results show that a flat leaves tree if does not validate LAI of 1, the ground shading would not fulfill about 50% direct radiation interception and this value can be used as a reference for urban trees selection. Further simulations were held to investigate LAI value of maximum direct radiation interception. Performing additional simulations, F. elastica of LAI of 3 intercepted almost 84% of direct radiation and revealed implications about urban trees in practice and its actual LAI. (author)

  5. Spectroscopic Characterization of Dust-Fall Samples Collected from Greater Cairo, Egypt.

    Science.gov (United States)

    Shaltout, Abdallah A; Allam, Mousa A; Mostafa, Nasser Y; Heiba, Zein K

    2016-04-01

    This work aimed to characterize dust-fall samples collected from street's trees in Greater Cairo (GC), Egypt, and its surroundings by different spectroscopic techniques, namely; X-ray diffraction (XRD), attenuated total-reflection Fourier transform infrared (ATR-FTIR), particle-size analyzer, and scanning electron microscopy (SEM) combined with energy dispersive X-ray measurements. Samples were collected from 19 different locations inside and outside of GC. Quantitative phase analysis of the dust-fall samples was performed using the Rietveld method. Results showed that the most frequently observed phases in the dust-fall samples were calcite (CaCO3), dolomite (CaMg(CO3)2), gypsum (CaSO4·2H2O), and quartz (SiO2) with average concentrations of 39 ± 16, 8 ± 7, 22 ± 13, and 33 ± 14 wt%, respectively. The occurrence of these constituents referred to a combination of different anthropogenic and natural sources. The ATR-FTIR results are in good agreements with XRD data of the different observed phases. Based on the SEM and particle-size measurements, quantitative determination of the particle-size distribution was described. It was found that not only the large-sized particles are deposited but also the small-sized ones (PM10 and PM2.5). In addition, the particle size of the collected dust-fall samples varied from 0.1 to 200 µm with an average particle size of 17.36 µm; however, the particle size ranged from 2.5 to 40 µm predominated in all of the dust-fall samples. PMID:26710766

  6. GROUND PENETRATING RADAR INVESTIGATIONS FOR ARCHITECTURAL HERITAGE PRESERVATION OF THE HABIB SAKAKINI PALACE, CAIRO, EGYPT

    Directory of Open Access Journals (Sweden)

    Sayed HEMEDA

    2012-09-01

    Full Text Available The modern architectural heritage of Egypt is both varied and vast. It covers all nonecclesiastical buildings, important monumental structures (mansions, municipal buildings in the history of architecture, as well as more common buildings. They include houses (from mansions to simple dwellings, public buildings (schools, administrative buildings, hospitals, industrial buildings (factories, warehouses, mills, bridges, monastic dependencies (drinking foundations, gardens and any other modern structures that fall within the category of monuments and comprise the Egyptian cultural heritage. We present herein a comprehensive Ground Penetration Radar (GPR investigation and hazard assessment for the rehabilitation and strengthening of Habib Sakakini’s Palace, in Cairo, considered one of the most significant architectural heritage sites in Egypt. The palace is located on an ancient water pond at the eastern side of the Egyptian gulf, beside the Sultan Bebris Al-Bondoqdary mosque, a place also called “Prince Qraja al-Turkumany pond”. That pond was drained by Habib Sakakini in 1892, to construct his famous palace in 1897. Eight hundred meters of Ground Penetration Radar (GPR profiling were conducted, to monitor the subsurface conditions. 600 meters were made in the surrounding area of the Palace and 200 m at the basement. The aim was to monitor the soil conditions beneath and around the Palace and to identify potential geological discontinuities, or the presence of faults and cavities. A suitable single and dual antenna were used (500-100 MHZ to penetrate to the desired depth of 7 meters (ASTM D6432. The GPR was also used to detect the underground water. At the building basement the GPR was used to identify the foundation thickness and the soil - basement interface, as well as for the inspection of cracks in some supporting columns, piers and masonry walls. All the results, together with the seismic hazard analysis, will be used for a complete

  7. Noise assessment inside the second-line of the Greater Cairo Underground Metro

    Indian Academy of Sciences (India)

    Mostafa E Aly

    2005-02-01

    Underground metro trains, which connect different terminals of big crowded cities, are the best means of public transportation. The metro is environmentally friendly because the trains are electrically driven and so do not emit chemical air-pollutants. The number of people using the Greater Cairo Underground Metro approaches two million per day, beside about one thousand workers in the different activities related to the metro. Metro users and workers complain about the high noise levels emitted by metro units travelling in the tunnels, especially at the turns, the entrance of tunnels and at stations while braking. Exposure to high noise levels for a long time causes many health hazards: either auditory, such as temporary and permanent hearing loss, or extra-auditory such as effects on the cardiovascular system, blood pressure, heart and respiratory rates, central nervous system. Noise also leads to stress problems such as lack of concentration, leading to accidents. Noise has adverse effects on psychological, biological, immunological and hormonal systems of the body. Due to the above mentioned reasons, suggestion has been made to start this research to assess and diagnose these problems, and to find the proper methods for early detection and proper management of these health hazards; in addition to the engineering solutions for the noise problem. Measurements of noise levels have been made inside the units while travelling and outside the units at the stations platforms to evaluate the noise problem and to suggest some kind of solutions to the problem. The calculations of different noise indices have been made and compared with international criteria and national laws. The comparison shows that the noise levels are clearly unacceptable, for indices $L_{1},L_{99},$ and LNP, both inside the metro units and outside the units at station platforms along the passage.

  8. Antimicrobial resistance in Cairo, Egypt 1999-2000: a survey of five hospitals.

    Science.gov (United States)

    El Kholy, Amani; Baseem, Hadia; Hall, Geraldine S; Procop, Gary W; Longworth, David L

    2003-03-01

    Antimicrobial resistance among bacterial pathogens is a global problem, but in Egypt data are sparse. We reviewed the antimicrobial susceptibility patterns of bloodstream isolates of Gram-positive cocci and Gram-negative bacilli in five hospitals in Cairo, Egypt, from 1999 to 2000. In addition, susceptibilities of non-bloodstream isolates of Streptococcus pneumoniae and Enterococcus spp. were analysed. High rates of resistance were found in most of the bacteria studied. In the hospitals, a variety of methods were used for identification and susceptibility testing, but in the laboratories quality controlled strains were utilized routinely, to ensure accurate performance of the assays. Only 29% of Staphylococcus aureus isolates and 23% of coagulase-negative staphylococcal isolates were oxacillin susceptible. Both groups of staphylococci were also highly resistant to erythromycin, co-trimoxazole, clindamycin and doxycycline; all isolates were susceptible to vancomycin. Susceptibility of S. pneumoniae isolates to penicillin, ceftriaxone and fluoroquinolones was 63%, 84% and 82%, respectively. Vancomycin susceptibility of the enterococci was 96%; susceptibility to high-level gentamicin and streptomycin was 54% and 48%, respectively. Resistance to most relevant antimicrobials was commonplace among the Gram-negative bacilli; however, most remained susceptible to imipenem. The percentage of bloodstream isolates of Escherichia coli susceptible to common antimicrobial agents was as follows: ampicillin (6%), ampicillin-sulbactam (38%), co-trimoxazole (38%) and aminoglycosides (52%). The susceptibility of isolates of E. coli, Klebsiella and Enterobacter spp. to ceftazidime was 62%, 40% and 46%, respectively. This suggests a potentially high rate of extended-spectrum beta-lactamase (ESBL) and/or Amp-C enzyme production. These results call for a nationwide surveillance programme to monitor microbial trends and antimicrobial resistance patterns in Egypt. PMID:12615864

  9. Medicolegal study of child sexual abuse in greater Cairo, Egypt, during a 7-year period: 2005-2011.

    Science.gov (United States)

    Elgendy, Ibrahim Sadik; Hassan, Nermeen Adly

    2013-12-01

    Child sexual abuse has gained public attention and has become 1 of the most high-profile crimes. This study aimed to determine the demographic and medicolegal aspects of child sexual abuse in greater Cairo, Egypt. This is a retrospective study from January 1, 2005, to December 31, 2011. Data were collected from a Cairo medicolegal department and were statistically analyzed. The total number of cases was 1832 victims; 57.9% were males and 42.1% were females. Most assaults occurred in 2010 (16.2%) and 2011 (17.5%). The age group 6 to 12 years accounted for higher rate (49%), mostly in males (71.8%). A total of 83.3% of the victims belonged to low social class, and 72.3% of the victims were out of school. Only 1.9% of the victims had a mental disability. The crime scene was an unknown place in 78.1%. All offenders were males; most cases had 1 offender (82.5 %); and most offenders were extrafamilial (94.2%), of low social level, illiterate, unemployed, and between 18 and 30 years old. The unmarried offenders assaulted the females more than the males, whereas the married assaulted the males more than the females. A total of 5.8% were intrafamilial offenders; 62.7% of these cases were incest against girls and 37.3% were sodomy against boys. Clothes were normal in 48.8%. Anal assault (52.3%) and incomplete vaginal penetration (32%) were the commonest types. There was no significant relation between findings, investigations, and time. In conclusion, child sexual abuse in greater Cairo represents a problem. Therefore,forensic medicine should be a part of a multidisciplinary approach to prevent, investigate, and treat the problem. PMID:24189631

  10. Time-Trend in Epidemiological and Pathological Features of Schistosoma-Associated Bladder Cancer

    International Nuclear Information System (INIS)

    To investigate the different emerging trends in the features of bladder cancer along 17 years. Patients and Methods: During a 17-year period (1988- 2004), 5071 epithelial bladder cancer patients underwent radical cystectomy at the National Cancer Institute (NCI), Cairo University, Egypt. The time was divided into 3 time periods to detect changes of the clinico pathologic features of patients in these periods. Results: There was a significant progressive increase in the patients' age with time and decrease in squamous/ transitional ratio, with transient increase in male predominance during the 2nd time period. Moreover, there was a decrease in the well differentiated (grade 1) tumor (p<0.001) and an increase in the frequency of pelvic nodal involvement (p<0.001). Transitional cell carcinoma (TCC) patients were significantly older than those with squamous cell carcinoma (SCC) (p<0.001). Progressive increase of age with time was evident in TCC, SCC and adenocarcinoma patients. Male to female ratio changed significantly in TCC and SCC. Conclusion: Time trend was confirmed with relative decrease in frequency of SCC and increase of TCC with changes in their pathological details. The differences between their characteristics and that of the Western countries are decreasing.

  11. Stress-induced perovskite to post-perovskite transition in CaIrO3 at room temperature

    Science.gov (United States)

    Cheng, J.-G.; Zhou, J.-S.; Goodenough, J. B.

    2010-10-01

    Depending on how the compound is synthesized, both perovskite and post-perovskite phases of the CaIrO3 can be obtained easily. However, a transition from the perovskite phase to the post-perovskite phase cannot be achieved under 30 GPa hydrostatic pressure at room temperature. By treating the perovskite sample in different pressure conditions from mostly hydrostatic pressure to uniaxial pressure and examining the residual strain in these samples with x-ray powder diffraction, we have shown that an irreversible transition from the perovskite phase to the post-perovskite phase occurs partially in the sample under a lattice shear stress at room temperature.

  12. Crystal structure of post-perovskite-type CaIrO3 reinvestigated: new insights into atomic thermal vibration behaviors

    OpenAIRE

    Akihiko Nakatsuka; Kazumasa Sugiyama; Akira Yoneda; Keiko Fujiwara; Akira Yoshiasa

    2015-01-01

    Single crystals of the title compound, the post-perovskite-type CaIrO3 [calcium iridium(IV) trioxide], have been grown from a CaCl2 flux at atmospheric pressure. The crystal structure consists of an alternate stacking of IrO6 octahedral layers and CaO8 hendecahedral layers along [010]. Chains formed by edge-sharing of IrO6 octahedra (point-group symmetry 2/m..) run along [100] and are interconnected along [001] by sharing apical O atoms to build up the IrO6 octahedral layers. Chains formed by...

  13. Nature of the Insulating Ground State of the 5d PostPerovskite CaIrO3

    OpenAIRE

    Kim, Sun-Woo; Liu, Chen; Kim, Hyun-Jung; Lee, Jun-Ho; Yao, Yongxin; Ho, Kai-Ming; Cho, Jun-Hyung

    2015-01-01

    The insulating ground state of the 5d transition metal oxide CaIrO3 has been classified as a Mott-type insulator. Based on a systematic density functional theory (DFT) study with local, semilocal, and hybrid exchange-correlation functionals, we reveal that the Ir t2g states exhibit large splittings and one-dimensional electronic states along the c axis due to a tetragonal crystal field. Our hybrid DFT calculation adequately describes the antiferromagnetic (AFM) order along the c direction via...

  14. Resonant X-Ray Diffraction Study of Strongly Spin-Orbit-Coupled Mott Insulator CaIrO3

    OpenAIRE

    Ohgushi, Kenya; Yamaura, Jun-ichi; Ohsumi, Hiroyuki; Sugimoto, Kunihisa; Takeshita, Soshi; Tokuda, Akihisa; Takagi, Hidenori; Takata, Masaki; Arima, Taka-hisa

    2011-01-01

    We performed resonant x-ray diffraction experiments at the $L$ absorption edges for the post-perovskite-type compound CaIrO$_{3}$ with $(t_{2g})^5$ electronic configuration. By observing the magnetic signals, we could clearly see that the magnetic structure was a striped order with an antiferromagnetic moment along the c-axis and that the wavefunction of a $t_{2g}$ hole is strongly spin-orbit entangled, the $J_{\\rm eff} =1/2$ state. The observed spin arrangement is consistent with theoretical...

  15. Thermal expansion of CaIrO3 post-perovskite determined by time-of-flight measurements

    Science.gov (United States)

    Aguado, F.; Hirai, S.; Redfern, S. A. T.; Smith, R. I.

    2014-11-01

    The thermal evolution of the CaIrO3 post-perovskite structure has been determined by neutron powder diffraction (time-of-flight) measurements in a wide temperature range, from 1.8K to 550K. The linear expansion is similar to that found in previous x-ray diffraction studies, being αb > αc > αa,. However, the difference in relative lattice parameters is less pronounced in the present case, suggesting a more isotropic evolution under temperature. Other structural differences found at low and high temperatures through several X-ray and neutron diffraction studies have been also analysed.

  16. Simulation of atmospheric temperature inversions over greater cairo using the MM5 Meso-Scale atmospheric model

    International Nuclear Information System (INIS)

    Air pollution episodes have been recorded in Cairo, during the fall season, since 1999, as a result of specific meteorological conditions combined with large quantity of pollutants created by several ground-based sources. The main reason for the smog-like episodes (black clouds) is adverse weather conditions with low and variable winds, high humidity and strong temperature inversions in the few-hundred meters above the ground. The two important types of temperature inversion affecting the air pollution are surface or ground (radiation) inversion and subsidence (elevated) inversion. The surface temperature inversion is associated with a rapid decrease in the ground surface temperature with the simultaneous existence of warm air in the lower troposphere. The inversion develops at dusk and continues until the surface warms again the following day. Pollutants emitted during the night are caught under this inversion lid.Subsidence inversion forms when warm air masses move over colder air masses. The inversion develops with a stagnating high-pressure system (generally associated with fair weather). Under these conditions, the pressure gradient becomes progressively weaker so that winds become light. These light winds greatly reduce the horizontal transport and dispersion of pollutants. At the same time, the subsidence inversion acts as a barrier to the vertical dispersion of the pollutants. In this study, the Penn State/NCAR meso -scale model (MM5) is used to simulate the temperature inversion phenomenon over Greater Cairo region during the fall season of 2004. Accurate computations of the heat transfer at the surface are needed to capture this phenomenon. This can only be achieved by high-resolution simulations in both horizontal and vertical directions. Hence, for accurate simulation of the temperature inversion over Greater Cairo, four nested domains of resolutions of 27 km, 9 km, 3 km and 1 km, respectively, were used in the horizontal planes. Furthermore, 42 levels

  17. Assessment of daily intake of major and trace elements by inhabitants of potential radiation protection of greater Cairo area, Egypt

    International Nuclear Information System (INIS)

    Concentrations of K, Ca, U, Th, Cs, Sr, I, Al, Cd, Cu, Mn, Pb, Ni and Cr were determined in vegetables, common foodstuffs and some animal products consumed by adult inhabitants of Greater Cairo Area. Some of these elements have chemical and biological similarity to some of the radionuclides abundantly encountered during nuclear power production and therefore data on these elements could provide important information on their biokinetic behavior. A total of 120 samples were analyzed using Neutron Activation Analysis (NAA) and Atomic Absorption Spectrometry (AAS). Generally, highest contributions for the intake of micro nutrients (Cu, Mn and Ni) arise from broad bean, rice and wheat flour consumption. Meat, milk, eggs and some vegetables are the major sources of K, Ca, U, Th, Cs, Al, Cd and Pb. The medium daily intake for the adult inhabitants of greater Cairo area was found to be 1.98 g of K, 0.54 mg of Ca, 1.14 fig of U, 0.8 μg of Th, 5.2μg of Cs, 1.3 mg of Sr, 105 μg of 1, 3.2 mg of Mn, 0.9 mg of Cu, 5.7 mg of Al, 5, 2 x 10-2mg of Pb, 2.1x10-3mg of Cd, 7.7x10-2mg of Ni and 2.1 x 10-2 mg of Cr. The lower daily intake of Ca, Th, Cs and I by adult inhabitants of greater Cairo area could be due to the significantly lower consumption of milk and milk products, which are rich in these elements. The significantly lower intake of calcium by adult inhabitants of greater Cairo area may lead to higher uptake of radiostrontium and could result in higher internal radiation dose. The use of highly sensitive and reliable analytical methods resulted in accurate assessment of the values recorded for thorium and uranium suggested that radiation dose from their ingestion at natural background levels, is likely to be lower than those included in ICRP data. Concerning micro nutrients, the recommended values of daily intake of Cu and Mn are conveniently supplied by the common diet; however for Cr is lower than the recommended daily allowance. Due to high metals concentrations and

  18. Thermal expansion of CaIrO3 post-perovskite determined by time-of-flight measurements

    International Nuclear Information System (INIS)

    The thermal evolution of the CaIrO3 post-perovskite structure has been determined by neutron powder diffraction (time-of-flight) measurements in a wide temperature range, from 1.8K to 550K. The linear expansion is similar to that found in previous x-ray diffraction studies, being αb > αc > αa,. However, the difference in relative lattice parameters is less pronounced in the present case, suggesting a more isotropic evolution under temperature. Other structural differences found at low and high temperatures through several X-ray and neutron diffraction studies have been also analysed

  19. Impact of tertiary Gleason pattern 5 on prostate cancer aggressiveness: Lessons from a contemporary single institution radical prostatectomy series

    Directory of Open Access Journals (Sweden)

    Zachary B. Koloff

    2015-01-01

    Conclusion: Our results emphasize the importance of TP5 and suggest that criteria for tertiary pattern reporting in prostate cancer should be standardized. Further studies are needed to evaluate the role of tertiary patterns in prognostic models.

  20. Multi-institutional phase II trial of intermediate risk prostate cancer treated with combination of external beam radiotherapy and high dose rate iridium brachytherapy

    International Nuclear Information System (INIS)

    A total of 84 intermediate risk prostate cancer (T2b or T2c, or 10< prostate specific antigen (PSA) ≤20 ng/ml, or Gleason score =7) patients were enrolled from five institutions. External beam radiotherapy were 3 Gy x 13 fraction =39 Gy and high dose rate iridium brachytherapy were 9 Gy x 2=18 Gy in one or two days. Primary endpoint of this study is the incidence of grade 3 late toxicity (NCI-CTC Ver.3) and secondary endpoint are acute toxicity and PSA relapse free rate. No grade 3 toxicity was observed and only one patient among 84 patients is noted PSA failure. Combined treatment of external beam radiotherapy and high dose rate iridium brachytherapy against intermediate risk of prostate cancer is safe and effective treatment. (author)

  1. Intraoperative radiation therapy delivered prior to lumpectomy for early-stage breast cancer: a single institution study

    OpenAIRE

    Yu, Wei; Lin, Zhi; Ju, Zhong-Jian; Li, Xi-Ru; ZHANG, YAN-JUN; Kong, Qing-Long; Gong, Han-Shun; Wang, Jian-Dong; Ma, Lin

    2015-01-01

    Objective: To evaluate the safety, cosmesis, and clinical outcome of intraoperative electron radiation therapy (IOERT) delivered prior to lumpectomy for early-stage breast cancer. Methods: From December 2008 to March 2012, 75 breast cancer patients (ages 34-66 years) were treated with IOERT during breast conservative surgery. IOERT was delivered using a mobile linear accelerator. Suitable energy and applicator size were chosen to ensure coverage of the tumor with anterior and posterior margin...

  2. Preoperative Nomograms for Predicting Extracapsular Extension in Korean Men with Localized Prostate Cancer: A Multi-institutional Clinicopathologic Study

    OpenAIRE

    Chung, Jae Seung; Choi, Han Yong; Song, Hae-Ryoung; Byun, Seok-Soo; Seo, Seong Il; Song, Cheryn; Cho, Jin Seon; Lee, Sang Eun; Ahn, Hanjong; Lee, Eun Sik; Kim, Won-Jae; Chung, Moon Kee; Jung, Tae Young; Yu, Ho Song; Choi, Young Deuk

    2010-01-01

    We developed a nomogram to predict the probability of extracapsular extension (ECE) in localized prostate cancer and to determine when the neurovascular bundle (NVB) may be spared. Total 1,471 Korean men who underwent radical prostatectomy for prostate cancer between 1995 and 2008 were included. We drew nonrandom samples of 1,031 for nomogram development, leaving 440 samples for nomogram validation. With multivariate logistic regression analyses, we made a nomogram to predicts the ECE probabi...

  3. Lumbosacral plexus delineation, dose distribution, and its correlation with radiation-induced lumbosacral plexopathy in cervical cancer patients

    Directory of Open Access Journals (Sweden)

    Tunio M

    2014-12-01

    Full Text Available Mutahir Tunio,1 Mushabbab Al Asiri,1 Yasser Bayoumi,2 Ali Abdullah O Balbaid,1 Majed AlHameed,3 Stanciu Laura Gabriela,1 Ahmad Amir O Ali1 1Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, Saudi Arabia; 2National Cancer Institute, Cairo University, Cairo, Egypt; 3Neurology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, Saudi Arabia Background: To evaluate the dose distribution to the lumbosacral plexus (LSP and its correlation with radiation-induced lumbosacral plexopathy (RILSP in patients with cervical cancer treated with intensity-modulated radiotherapy (IMRT and high-dose-rate brachytherapy.Materials and methods: After meeting eligibility criteria, 50 patients with cervical cancer were selected who were treated with IMRT and high-dose-rate brachytherapy, and the LSP was contoured. Mean volume; percentages of LSP volume absorbing 40, 50, 55, and 60 Gy (V30, V40, V50, V55, and V60 and point doses (P1, P2, P3, P4, P5, P6, P7, P8, P9, and P10; and RILSP incidence were calculated.Results: At 60 months of follow-up, four patients (8% were found to have grade 2/3 RILSP. The mean maximal LSP dose in patients with RILSP was 59.6 Gy compared with 53.9 Gy in patients without RILSP (control; P=0.04. The mean values of V40, V50, V55, and V60 in patients with RILSP versus control were 61.8% versus 52.8%, 44.4% versus 27.7%, 8.0% versus 0.3% and 1.8% versus 0%, respectively (P=0.01, 0.001, 0.001, and 0.001, respectively.Conclusion: The delineation of the LSP during IMRT planning may reduce the risk for RILSP. The mean values of V40, V50, V55, and V60 for LSP should be less than 55%, 30%, 5%, and 0.5%, respectively; however, further studies are warranted.Keywords: cervical cancer, intensity-modulated radiation therapy, lumbosacral plexus delineation, radiation-induced lumbosacral plexopathy, dosimetric analysis

  4. Preliminary phase II results of selinexor, an oral selective inhibitor of nuclear export in patients with heavily pretreated gynecological cancers

    DEFF Research Database (Denmark)

    Vergote, Ignace; Lund, Bente; Havsteen, Hanne;

    2015-01-01

    stages of the disease. We here propose a randomized trial in order to demonstrate that resection of the primary tumour improves overall survival. METHODS/DESIGN: The CAIRO4 study is a multicentre, randomized, phase III study of the Dutch Colorectal Cancer Group (DCCG). Patients with synchronous...

  5. Two-fraction high-dose-rate brachytherapy within a single day combined with external beam radiotherapy for prostate cancer: single institution experience and outcomes

    OpenAIRE

    Liu, Junyang; Kaidu, Motoki; Sasamoto, Ryuta; Ayukawa, Fumio; Yamana, Nobuko; Sato, Hiraku; Tanaka, Kensuke; Kawaguchi, Gen; Ohta, Atsushi; Maruyama, Katsuya; Abe, Eisuke; Kasahara, Takashi; Nishiyama, Tsutomu; Tomita, Yoshihiko; Aoyama, Hidefumi

    2016-01-01

    We investigated the outcomes of treatment for patients with localized prostate cancer (PCa) treated with 3D conformal radiation therapy (3D-CRT) followed by two-fraction high-dose-rate brachytherapy within a single day (2-fr.-HDR-BT/day) at a single institution. A total of 156 consecutive Asian males (median age, 67 years) were enrolled. To compare our findings with those of other studies, we analyzed our results using the D'Amico classification, assigning the patients to low- ( n =5; 3.2%), ...

  6. Cancer of Unknown Primary Site:A Review of 28 Cases and the Efficacy of Cisplatin/Docetaxel Therapy at a Single Institute in Japan

    OpenAIRE

    Nishimori, Hisakazu; TAKAHASHI, SHUNJI; Kiura, Katsuyuki; Ennishi, Daisuke; Kobayashi, Takayuki; Sano,Koji; SHINOZAKI, EIJI; Yokoyama, Masahiro; Mishima, Yuko; Terui, Yasuhito; Chin,Keisho; Mizunuma, Nobuyuki; Ito, Yoshinori; Nishimura, Seiichiro; Takeuchi, Kengo

    2010-01-01

    We evaluated the efficacy and toxicity of cisplatin/docetaxel (CDDP/TXT) chemotherapy and identified prognostic factors in Japanese patients with cancer of unknown primary site (CUP). Twenty-eight consecutive patients seen at a single institute were reviewed retrospectively. Sixteen patients were treated with TXT 80mg/m2, followed by CDDP 75mg/m2. The overall response rate to CDDP/TXT treatment was 62.5%, with a median survival time (MST) of 22.7 months. Common adverse reactions were myelosup...

  7. Cancer-specific survival after radical nephroureterectomy for upper urinary tract urothelial carcinoma: proposal and multi-institutional validation of a post-operative nomogram

    OpenAIRE

    Yates, D R; Hupertan, V.; Colin, P.; Ouzzane, A; Descazeaud, A; Long, J. A.; Pignot, G; Crouzet, S; Rozet, F; Neuzillet, Y; Soulie, M.; Bodin, T; Valeri, A.; Cussenot, O; Rouprêt, M

    2012-01-01

    Background: Owing to the scarcity of upper urinary tract urothelial carcinoma (UUT-UC) it is often necessary for investigators to pool data. A patient-specific survival nomogram based on such data is needed to predict cancer-specific survival (CSS) post nephroureterectomy (NU). Herein, we propose and validate a nomogram to predict CSS post NU. Patients and methods: Twenty-one French institutions contributed data on 1120 patients treated with NU for UUT-UC. A total of 667 had full data for nom...

  8. Multi-institutional comparison of volumetric modulated arc therapy vs. intensity-modulated radiation therapy for head-and-neck cancer: a planning study

    International Nuclear Information System (INIS)

    Compared to static beam Intensity-Modulated Radiation Therapy (IMRT), the main advantage of Volumetric Modulated Arc Therapy (VMAT) is a shortened delivery time, which leads to improved patient comfort and possibly smaller intra-fraction movements. This study aims at a treatment planner-independent comparison of radiotherapy treatment planning of IMRT and VMAT for head-and-neck cancer performed by several institutes and based on the same CT- and contouring data. Five institutes generated IMRT and VMAT plans for five oropharyngeal cancer patients using either Pinnacle3 or Oncentra Masterplan to be delivered on Elekta linear accelerators. Comparison of VMAT and IMRT plans within the same patient and institute showed significantly better sparing for almost all OARs with VMAT. The average mean dose to the parotid glands and oral cavity was reduced from 27.2 Gy and 39.4 Gy for IMRT to 25.0 Gy and 36.7 Gy for VMAT, respectively. The dose conformity at 95% of the prescribed dose for PTVboost and PTVtotal was 1.45 and 1.62 for IMRT and 1.37 and 1.50 for VMAT, respectively. The average effective delivery time was reduced from 13:15 min for IMRT to 5:54 min for VMAT. Independently of institution-specific optimization strategies, the quality of the VMAT plans including double arcs was superior to step-and-shoot IMRT plans including 5–9 beam ports, while the effective treatment delivery time was shortened by ~50% with VMAT

  9. In-situ measurement of texture development rate in CaIrO3 post-perovskite

    Science.gov (United States)

    Hunt, Simon A.; Walker, Andrew M.; Mariani, Elisabetta

    2016-08-01

    The rate of crystallographic preferred orientation (CPO) development during deformation of post-perovskite is crucial in interpreting seismic anisotropy in the lowermost mantle but the stability field of MgSiO3 post-perovskite prevents high-strain deformation experiments being performed on it. Therefore, to constrain the rate of CPO development in post-perovskite, we deformed CaIrO3, a low-pressure analogue of MgSiO3 post-perovskite, in simple shear at 3.2 GPa and 400 °C to a shear strain (γ) of 0.81. From X-ray diffraction patterns acquired during deformation, we invert for CPO as a function of strain. By comparing the CPO that develops with visco-plastic self-consistent (VPSC) models we constrain the critical resolved shear stresses (CRSS) of the non-primary slip-systems in CaIrO3 to be of order 6 times stronger than the primary [ 1 0 0 ] (0 1 0) slip system. This value is significantly less than has been assumed by previous studies and if applicable to MgSiO3 implies that seismic anisotropy in the D″ layer develops slower than has previously been assumed.

  10. Determination of rare earth elements in dust deposited on tree leaves from Greater Cairo using inductively coupled plasma mass spectrometry

    International Nuclear Information System (INIS)

    This work aims at monitoring the rare earth elements (REEs) and Th in dust deposited on tree leaves collected inside and outside Greater Cairo (GC), Egypt. Inductively coupled plasma mass spectrometry (ICP-MS) was employed. The concentration of REEs in the collected dust samples was found to be in the range from 1 to 60 μg g−1. The highest concentration of REEs was found in dust samples collected outside GC, in the middle of the Nile Delta. This would refer to the availability of black sands, due to desert wind occurrence during the sample collection, and anthropogenic activities. The limits of detection of the REEs ranged from 0.02 ng g−1 for Tm to 3 ng g−1 for Yb. There was an obvious variation in the concentration of REEs inside and outside GC due to variations of natural and anthropogenic sources. Strong correlations among all the REEs were found. -- Highlights: •Rare earth elements (REEs) were determined in dust samples using ICP-MS. •The dusts were deposited on tree leaves and were collected at 19 sites. •REE concentrations were in the range from 1 to 60 μg g−1. •High concentration of REEs was found in the middle of Nile Delta. -- For the first time, rare earth elements (REEs) and Th were determined in dust deposited on tree leaves collected at 19 sites in the Greater Cairo

  11. Land Cover Mapping Analysis and Urban Growth Modelling Using Remote Sensing Techniques in Greater Cairo Region—Egypt

    Directory of Open Access Journals (Sweden)

    Yasmine Megahed

    2015-09-01

    Full Text Available This study modeled the urban growth in the Greater Cairo Region (GCR, one of the fastest growing mega cities in the world, using remote sensing data and ancillary data. Three land use land cover (LULC maps (1984, 2003 and 2014 were produced from satellite images by using Support Vector Machines (SVM. Then, land cover changes were detected by applying a high level mapping technique that combines binary maps (change/no-change and post classification comparison technique. The spatial and temporal urban growth patterns were analyzed using selected statistical metrics developed in the FRAGSTATS software. Major transitions to urban were modeled to predict the future scenarios for year 2025 using Land Change Modeler (LCM embedded in the IDRISI software. The model results, after validation, indicated that 14% of the vegetation and 4% of the desert in 2014 will be urbanized in 2025. The urban areas within a 5-km buffer around: the Great Pyramids, Islamic Cairo and Al-Baron Palace were calculated, highlighting an intense urbanization especially around the Pyramids; 28% in 2014 up to 40% in 2025. Knowing the current and estimated urbanization situation in GCR will help decision makers to adjust and develop new plans to achieve a sustainable development of urban areas and to protect the historical locations.

  12. Urban-rural solar radiation loss in the atmosphere of Greater Cairo region, Egypt

    International Nuclear Information System (INIS)

    A comparative study for measured global solar radiation, G, during the period (1969-2006) and the corresponding global radiation loss in the atmosphere, RL%, over urban and rural districts in Greater Cairo region have been performed. The climatic variabilities of G radiation at the urban and rural sites are also investigated and discussed. Monthly, seasonal and annual mean values of extraterrestrial radiation, Go, and RL% during four successive periods, (1969-1978), (1979-1988), (1989-1998) and (1999-2006) at the above two sites have been calculated and investigated. The results revealed that urban area was always received lower amount of solar radiation due to urbanization factors. The yearly mean values of G radiation were distinctly decreased from maximum value 21.93 and 22.62 MJ m-2 during 1970 year to minimum value 17.57 and 17.87 MJ m-2 during 2004 and 2006 years with average decrease rate 0.09 and 0.10 MJ m-2 per year for the urban and rural areas, respectively. Also, the seasonal and annual mean anomalies of G radiation have been also gradually decreased from maximum values during the eldest period (1969-1978) to minimum values during the recent period (1999-2006). RL% over the urban area was always higher than that rural area. The urban-rural RL% differences range from 0.61% in 1999 year to 4.19% in 2002 year and 2.20% as average value. The yearly mean of RL% values distinctly gradually increase from minimum value 29.47% and 27.28% during 1970 year to maximum value 43.50% and 42.60% during 2004 and 2006 years with average increase rate 0.28% and 0.32% per year for the urban and rural areas, respectively. The minimum value of RL% (26.88%) occurred at rural area during summer season of the eldest period (1969-1978) while the maximum value of RL% (51.27%) occurred at the urban area during winter season of the last recent urbanized period (1999-2006). The linear trend of the yearly variations of RL% revealed that G values will reach zero over the urban and

  13. Assessment of anthropogenic nitrate pollution in groundwater in northeast Cairo using nitrogen-15 technique

    International Nuclear Information System (INIS)

    Groundwater contamination of elevated nitrate ions was investigated in a limited area of the north-eastern part of Cairo (EI-Gabal EI-Asfar farm and its surroundings). Stable isotope techniques of nitrogen (δ15N), oxygen (δ18O), and hydrogen (δ2H) with major ions and trace elements analyses followed by data evaluation were combined to assess the potential sources and fate of nitrate contamination. In the studied area, the unconfined aquifer system is found to be vulnerable to nitrate impacts from land uses because of the sandy, permeable soils and a relatively shallow depth to groundwater. Several potential sources of elevated nitrate exist including a rapid infiltration of sewage effluents, used for irrigation, soil organic and inorganic nitrogen, and land application of animal wastes (manure), sludge, and inorganic chemical fertilizers. Surface and ground water samples as well as surface soil samples were collected beside the principal nitrate sources that are likely to affect groundwater quality. Data revealed that surface and groundwater samples have high TDS, nitrate, phosphate, and trace elements contents especially at the north-eastern pad and at the southern part of the studied area. Soil samples show relative enrichment in trace elements and total nitrogen contents due to prolonging sewage water irrigation especially at EI-Gabal EI-Asfar farm and at the northern part of the studied area. Results of δ18O and δ2H for most of groundwater samples mainly reflect more enriched values than that of Nile River due to recycling of water used for irrigation. The δ15N values of nitrate in water samples indicate that the source yielding lower nitrate concentrations could be commercial fertilizers or nitrifying soil organic nitrogen which is more pronounced at the western part. In the north-eastern part other sources being responsible for the higher nitrate concentrations appears to be mixing with sewage or manure and ammonium phosphate fertilizer. This mixing

  14. Survival in women with ovarian cancer before and after the introduction of adjuvant paclitaxel; a 25-year, single institution review.

    LENUS (Irish Health Repository)

    Shireen, R

    2012-02-01

    Adjuvant chemotherapy regime for ovarian cancer patients remains to be a contentious issue. The aim of this study was to compare the overall and progression-free survival of women with ovarian cancer before and after introduction of paclitaxel in our unit in 1992. A sample of 112 women who received adjuvant therapy following surgery for ovarian cancer was collected, 68 (61%) received platinum+alkylating agent before 1992 and later 44 (39%) received platinum+paclitaxel. Five-year survival was same in both treatment groups when there was no macroscopic disease after surgery (78% versus 70%) and when residual disease was <2 cm (50% versus 40%). Survival was greater in women with residual disease >2 cm in the platinum+paclitaxel group (50% versus 24%), (p = 0.04). However, progression-free survival was similar in both groups irrespective of stage or residual volume of disease. Therefore consideration to selective use of paclitaxel could reduce patient morbidity and costs significantly.

  15. Cancer Institute of New Jersey: University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey. Environmental Assessment

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    The Department of Energy (DOE) proposes to authorize the University of Medicine and Dentistry of New Jersey to proceed with the design, construction, and equipping of the proposed Clinical Treatment and Research Facility of the University of New Jersey on the New Brunswick campus. The facility will provide for the integration of new and existing clinical outpatient cancer treatment with basic and clinical research to expedite the application of new discoveries in cancer treatment. Based on the analysis in the environmental assessment, DOE has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act (NEPA).

  16. Study of the pollution impact from the usage of sewage and drainage waters on the groundwater of the quaternary aquifer, West Cairo, Egypt

    International Nuclear Information System (INIS)

    The aim of this study is to assess the water quality of surface and groundwater in the western part of Cairo and to estimate the sources of pollution as salinisation, nutrients, trace elements and microbiological activity as a result of re-use of partially treated drainage and sewage waters for irrigation

  17. Texture development and TEM analysis of deformed CaIrO3: Implications for the D'' layer at the core-mantle boundary

    Science.gov (United States)

    Walte, Nicolas; Heidelbach, Florian; Miyajima, Nobuyoshi; Frost, Daniel

    2007-04-01

    CaIrO3 is an isostructural analog for MgSiO3 post-perovskite (ppv), likely the dominant mineral phase in the D'' layer. At high temperature CaIrO3 undergoes a phase transition to a perovskite (pv) structure. We have performed deformation experiments of CaIrO3 pv and ppv with the deformation-DIA apparatus. The deformed pv does not display any discernable texture even after strong coaxial shortening. In contrast, ppv displays a strong lattice preferred orientation (LPO) with the a-axis parallel to the shear direction and the b-axis perpendicular to the shear plane. Calculation of the seismic properties predicts a shear wave splitting with a maximum of 2.7% in the shear plane, which is qualitatively compatible with seismic measurements. Ppv displayed a high density of (010)[100] dislocations, consistent with the textural results. Thus, our experiments on CaIrO3 pv and ppv are compatible with a seismically isotropic lower mantle and anisotropic D'' layer in the Earth.

  18. The 4th Euro-Mediterranean Conference of Natural Products and Drug Discovery: Back to Mother Nature (BioNat-IV, Cairo/Sharm El-Sheikh, Egypt, March 3–7, 2015

    Directory of Open Access Journals (Sweden)

    Ashraf A. Khalil

    2016-04-01

    Full Text Available The 4th Euro-Mediterranean Conference of Natural Products and Drug Discovery: Back to Mother Nature (BioNat-IV was recently (from March 3rd through 7th, 2015 convened in Cairo and Sharm El-Sheikh along the Red Sea coast of Egypt. Overall, the meeting provided a platform for scientists from different nations to discuss emerging ideas that focused on cell signaling in cancer; the pathogenesis of autoimmune diseases; the identification and use of natural products as well as novel drug delivery approaches for the treatment of cancer, arthritis, diabetes, tuberculosis, fungal infection, etc.; and untapped or unconventional sources for natural products. This fourth in a row conference tried to bridge the gap not only between basic research and clinical applications, but also between developed nations and developing countries. With the continuing success of these past meetings, the fifth Euro-Mediterranean Conference of Natural Products and Drug Discovery (BioNat-V is slated to be in February 2017.

  19. Formal and informal Patronage among Jews in the Islamic East: evidence from the Cairo Geniza

    Directory of Open Access Journals (Sweden)

    Rustow, Marina

    2008-12-01

    Full Text Available This paper investigates the political culture of the Islamic East under Fatimid and Buwayhid rule (tenth-twelfth centuries via relationships between patrons, clients, protégés, and partners. The main body of evidence I utilize are letters and petitions from the Cairo Geniza that employ the same specialized vocabulary of patron-client relationships one finds in Arabic histories of the period: idioms referring to the exchange of benefit, reciprocal service, protection, oversight, patronage, and loyalty. The Geniza letters, written without regard for posterity, suggest that these idioms were used well beyond the courts and were understood and deployed by men and women, the literate and illiterate, the important and the inconsequential. Yet the use of certain terms in Judaeo-Arabic also differs from their use in Arabic: some reflect devaluation over time, while others hardened into formulaic phrases. These differences suggest that some forms of patronage did not thrive beyond the hothouse of the court; viewed from another perspective, they also suggest that even outside courtly literature, one can retrieve fossils of older forms of patronage in the terms used to describe relationships between leaders and their followers as well as among people more nearly equal in station. A society’s use of social metaphors reveals something of what its members value, what they choose to retain and perpetuate from the past, how they function in moments of crisis, and how successfully their rulers have managed to convince them of the legitimacy of the social and political order. Conversely, the vocabulary of patronage was a social technique that allowed Jews to conduct business, engage in politics and communal regulation, and to amass and retain followers in a variety of spheres, including that of the rabbinic academies who proffered the construction of Judaism that became hegemonic over the course of the Middle Ages.

    Este artículo aborda la cultura pol

  20. Hypofractionated Volumetric Modulated Arc Radiotherapy with simultaneous Elective Nodal Irradiation is feasible in prostate cancer patients: A single institution experience

    Directory of Open Access Journals (Sweden)

    Mohamed W. Hegazy

    2016-06-01

    Conclusions: Hypo-fractionation dose escalation VMAT–SIB–ENI–WPRT using 2 arcs is a feasible technique for intermediate/high risk OC prostate cancer patients, with acceptable rates of acute/late toxicities, much favorable planning target volume (PTV coverage, and shorter overall treatment time. Prospective randomized controlled trials are encouraged to confirm its equivalence to other fractionation schemes.

  1. Prevalence based epigrammatic study of oral cancer and other mucosal disorders in elderly patients visiting dental institution of Northern India

    Directory of Open Access Journals (Sweden)

    Basavaraj T Bhagawati

    2013-01-01

    Full Text Available Objective : This report provides the descriptive information about the oral health among the elderly population. The objective is to assess the association of age, medical status, recent use of dental services, habits and dentures with that of oral cancer, and other mucosal disorders. Materials and Methods: Data from the interviews and clinical examination of 285 persons aged above 60 years were obtained. Patients were divided into three groups of 75 patients each with age group of 60-65 years, 66-70 years, and 71 years above, respectively. Patients were examined and questioned regarding the oral health complaints and the presence of cancer and other mucosal disorders. Results: There are no statistically significant differentiates between the three groups in terms of oral health complaint, medical status. The patients in all the three groups gave the history of consumption of betel quid/alcohol/smoking. About 22.1% patients in Group A, 18.9% in Group B, and 37.9% in Group C had associated mucosal lesion like oral cancer, growth, pigmentation, red lesion, ulcer, and white lesions. Association between deleterious habits and oral mucosal lesions was seen in 12, 15, and 16 patients in Groups A, B, and C, respectively. Conclusion: The oral cancer and oral mucosal lesions were associated with oral habits and the use of faulty dentures. Age had minimal influence but coexistence of multiple conditions might further complicate the oral health.

  2. Laparoscopic versus Open Surgery for Colorectal Cancer: A Retrospective Analysis of 163 Patients in a Single Institution

    Science.gov (United States)

    Bedirli, Abdulkadir; Salman, Bulent; Yuksel, Osman

    2014-01-01

    Background. The present study aimed to compare the clinical outcomes of laparoscopic versus open surgery for colorectal cancers. Materials and Methods. The medical records from a total of 163 patients who underwent surgery for colorectal cancers were retrospectively analyzed. Patient's demographic data, operative details and postoperative early outcomes, outpatient follow-up, pathologic results, and stages of the cancer were reviewed from the database. Results. The patients who underwent laparoscopic surgery showed significant advantages due to the minimally invasive nature of the surgery compared with those who underwent open surgery, namely, less blood loss, faster postoperative recovery, and shorter postoperative hospital stay (P 0.05). Open surgery resulted in more incisional infections and postoperative ileus compared with laparoscopic surgery (P < 0.05). There were no differences in the pathologic parameters between two groups (P < 0.05). Conclusions. These findings indicated that laparoscopic surgery for colorectal cancer had the clear advantages of a minimally invasive surgery and relative disadvantage with longer surgery time and exhibited similar pathologic parameters compared with open surgery. PMID:25506425

  3. Radiotherapy in the cavum cancer: analysis of 30 cases treated in our institution in Beirut; La radiotherapie dans le cancer du cavum: analyse de 30 cas traites dans notre institution a Beyrouth

    Energy Technology Data Exchange (ETDEWEB)

    Helou, J.; Nasr, E.; Nasr, D.N.; Haddad, A. [service de radio-oncologie, Hotel-Dieu-de-France, Beyrouth (Lebanon); Rizk, H.; Melkane, A.; Tabchy, B. [service d' oto-rhino-laryngologie, Hotel-Dieu-de-France, Beyrouth (Lebanon); Chahine, G.; Ghosn, M. [service d' oncologie, Hotel-Dieu-de-France, Beyrouth (Lebanon); Khater, C. [service d' oncologie, Saint-Charles, Beyrouth (Lebanon)

    2010-10-15

    The authors describe the results obtained for nasopharyngeal cancers treated by irradiation, exclusively or in combination with chemotherapy. They also assess the impact of the different pathological and clinic variables on survival without relapse. The study is based on a sample of 30 patients treated between 1999 and 2009. Local control, metastatic dissemination, and toxicity are analysed and discussed. A ganglionary extension seems to be the worst prognostic factor. Short communication

  4. Stakeholder perspectives on implementing the National Cancer Institute's patient-reported outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE).

    Science.gov (United States)

    Bruner, Deborah Watkins; Hanisch, Laura J; Reeve, Bryce B; Trotti, Andy M; Schrag, Deborah; Sit, Laura; Mendoza, Tito R; Minasian, Lori; O'Mara, Ann; Denicoff, Andrea M; Rowland, Julia H; Montello, Michael; Geoghegan, Cindy; Abernethy, Amy P; Clauser, Steven B; Castro, Kathleen; Mitchell, Sandra A; Burke, Laurie; Trentacosti, Ann Marie; Basch, Ethan M

    2011-03-01

    The National Cancer Institute (NCI) is developing a patient-reported version of its Common Terminology Criteria for Adverse Events, called the "PRO-CTCAE." The PRO-CTCAE consists of a library of patient-reported items which can be administered in clinical trials to directly capture the patient experience of adverse events during cancer treatment, as well as a software platform for administering these items via computer or telephone. In order to better understand the impressions of stakeholders involved in cancer clinical research about the potential value of the PRO-CTCAE approach to capturing adverse event information in clinical research, as well as their perspectives about barriers and strategies for implementing the PRO-CTCAE in NCI-sponsored cancer trials, a survey was conducted. A survey including structured and open-ended questions was developed to elicit perceptions about the use of patient-reported outcomes (PROs) for adverse event reporting, and to explore logistical considerations for implementing the PRO-CTCAE in cancer trials. The survey was distributed electronically and by paper to a convenience sample of leadership and committee members in the NCI's cooperative group network, including principal investigators, clinical investigators, research nurses, data managers, patient advocates, and representatives of the NCI and Food and Drug Administration. Between October, 2008 through February, 2009, 727 surveys were collected. Most respondents (93%) agreed that patient reporting of adverse symptoms would be useful for improving understanding of the patient experience with treatment in cancer trials, and 88%, 80%, and 76%, respectively, endorsed that administration of PRO-CTCAE items in clinical trials would improve the completeness, accuracy, and efficiency of symptom data collection. More than three fourths believed that patient reports would be useful for informing treatment dose modifications and towards FDA regulatory evaluation of drugs. Eighty

  5. Assessment of treatment tolerance and response of elderly head and neck cancer patients: A single institution retrospective study

    Directory of Open Access Journals (Sweden)

    Vivek Tiwari

    2015-01-01

    Full Text Available Background: Head and neck (H and N cancers are the leading cancer in elderly Indian population especially in Central India. Poor socioeconomic (SE factors, lack of knowledge, and that of proper facilities is responsible for delayed presentation in advanced stages of the disease. Management of such patients is challenging for an oncologist. Aim: The present study evaluated the pattern of tolerance and response to treatment in elderly (>65 years H and N cancer patients. Materials and Methods: Medical records of elderly H and N cancer patients presenting from January to December 2014 to the Department of Radiotherapy, Gandhi Medical College, Bhopal were reviewed, and data were collected from the departmental case files. Results: A total 112 patients were selected for this study. The mean age of presentation was 70 years. There was a marked male preponderance, with male to female ratio of 5.22:1. 102 patients presented in advanced stages (stage III and IV. The mean duration of symptoms was 6.5 months. Records of 99 patients were available and further analyzed. 59 patients were advised three courses of induction chemotherapy (CT out of which 44 patients completed the treatment. 28 of these patients showed a positive response to the treatment while 16 showed no response (NR/progression. Similarly, 24 patients were advised concurrent chemoradiotherapy out of which 17 patients completed the treatment. 13 of these patients showed a positive response while 04 showed NR/progression. On subgroup analysis, the difference between tolerance, response and overall treatment time between the two arms was not statistically significant. Conclusions: Treating elderly H and N cancer patients is a major therapeutic challenge for a clinician because of its poor prognosis, aggressive clinical behavior, associated co-morbidities, and SE factors. However, it is possible to achieve a quality outcome in select patients with basic CT and radiation.

  6. Cisplatin-based chemotherapy: the only alternative in chemoradiation of head and neck cancer? Experience of the Institute of Oncology, Ljubljana, Slovenia

    International Nuclear Information System (INIS)

    Background: Concomitant chemoradiation is a widely used therapeutic concept in intensified locoregional treatment of high risk head and neck cancer patients. In this context, cisplatin monotherapy or in combination with other chemotherapeutics is recognized as the most effective drug to be added to radiotherapy. Aim: The aim of this review is to present the rationale for combining radiotherapy with cisplatin in the treatment of head and neck cancer and to summarize the experience of the Institute of Oncology Ljubljana, Slovenia, gained through two prospective randomized trials on chemoradiation with mitomycin C and bleomycin in operable as well as inoperable head and neck cancer patients. Furthermore, recent developments in technology and biological drug modeling are discussed, which are considered to have a potential to add significantly to the locoregional effectiveness of radiotherapy. Materials/Methods: References were retrieved using the online data base of the National Library of Medicine (PubMed: http://www.ncbi.nlm.nih.gov/PubMed). Terms used included: head and neck carcinoma, squamous cell carcinoma, concomitant chemoradiotherapy, cisplatin, mitomycin C, bleomycin. The results of studies using cisplatin- based chemoradiation regimens in the treatment of patients with inoperable tumors and on postoperative stetting were compared with the results of the studies, conducted at the Institute of Oncology and ENT Department at the Clinical Center Ljubljana, Slovenia. Results; When comparing mitomycin C-bleomycin chemotherapy with other comparable series on exclusively inoperable oropharyngeal cancer, but with cisplatin (or carboplatin) and 5-fluorouracil chemotherapy, and to standard dose cisplatin regimen used in postoperative setting, the effectiveness of our unconventional drug combination appeared to be at least equivalent to the well established platinum based chemotherapy standard. Conclusions: At the moment, concomitant chemoradiation with cisplatin

  7. Techniques for thyroid FNA: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference.

    Science.gov (United States)

    Pitman, Martha Bishop; Abele, John; Ali, Syed Z; Duick, Dan; Elsheikh, Tarik M; Jeffrey, R Brooke; Powers, Celeste N; Randolph, Gregory; Renshaw, Andrew; Scoutt, Leslie

    2008-06-01

    The National Cancer Institute (NCI) sponsored the NCI Thyroid fine-needle aspiration (FNA) State of the Science Conference on October 22-23, 2007 in Bethesda, MD. The 2-day meeting was accompanied by a permanent informational website and several on-line discussion periods between May 1 and December 15, 2007 (http://thyroidfna.cancer.gov). This document summarizes matters addressing manual and ultrasound guided FNA technique and related issues. Specific topics covered include details regarding aspiration needles, devices, and methods, including the use of core needle biopsy; the pros and cons of anesthesia; the influence of thyroid lesion location, size, and characteristics on technique; the role of ultrasound in the FNA of a palpable thyroid nodule; the advantages and disadvantages of various specialists performing a biopsy; the optimal number of passes and tissue preparation methods; sample adequacy criteria for solid and cystic nodules, and management of adverse reactions from the procedure. (http://thyroidfna.cancer.gov/pages/info/agenda/) PMID:18478608

  8. DYPD genotyping to predict toxicity in patients with stage III colon cancer treated with 5-fluorouracil-based adjuvant chemotherapy in the PETACC-8 phase III trial

    DEFF Research Database (Denmark)

    Boige, Valérie; Vincent, Marc; Alexandre, Philippe;

    2015-01-01

    stages of the disease. We here propose a randomized trial in order to demonstrate that resection of the primary tumour improves overall survival. METHODS/DESIGN: The CAIRO4 study is a multicentre, randomized, phase III study of the Dutch Colorectal Cancer Group (DCCG). Patients with synchronous...

  9. Pre-Prosthetic surgical alterations in maxillectomy to enhance the prosthetic prognoses as part of rehabilitation of oral cancer patient

    Science.gov (United States)

    El Fattah, Hisham; Zaghloul, Ashraf; Escuin, Tomas

    2012-01-01

    Objectives: After maxillectomy, prosthetic restoration of the resulting defect is an essential step because it signals the beginning of patient’s rehabilitation. The obturator used to restore the defect should be comfortable, restore adequate speech, deglutition, mastication, and be cosmetically acceptable, success will depend on the size and location of the defect and the quantity and integrity of the remaining structures, in addition to pre-prosthetic surgical preparation of defect site. Preoperative cooperation between the oncologist surgeon and the maxillofacial surgeon may allow obturation of a resultant defect by preservation of the premaxilla or the tuberosity on the defect side and maintaining the alveolar bone or teeth adjacent to the defect. This study evaluates the importance of pre-prosthetic surgical alterations at the time maxillectomy on the enhancement of the prosthetic prognoses as part of the rehabilitation of oral cancer patient. Study Design: The study was carried out between 2003- 2008, on 66 cancer patients(41 male-25 female) age ranged from 33 to 72 years, at National Cancer Institute, Cairo University, whom underwent maxillectomy surgery to remove malignant tumor as a part of cancer treatment. Patients were divided in two groups. Group A: Resection of maxilla followed by preprosthetic surgical preparation. Twenty-four cancer patients (13 male – 11 female). Group B: Resection of maxilla without any preprosthetic surgical preparation. Forty-two cancer patients (28 male-14 female). Results: Outcome variables measured included facial contour and aesthetic results, speech understandability, ability to eat solid foods, oronasal separation, socializing outside the home, and return-to-work status. Flap success and donor site morbidity were also studied. Conclusions: To improve the prosthetic restoration of maxillary defect resulting maxillary resection as part treatment of maxillofacial tumor depends on the close cooperation between

  10. Deformation and Texture Development in CaIrO3: Implications for the Seismic Properties of the D" Layer

    Science.gov (United States)

    Walte, N. P.; Miyajima, N.; Heidelbach, F.; Frost, D. J.

    2006-12-01

    Experimental and numerical studies have linked the D" layer at the core-mantle boundary to a phase transition from the MgSiO3 perovskite (Pv) structure to a layered post-perovskite structure (pPv) at approximately 135 GPa. As a result it becomes plausible to explain seismic velocity heterogeneity and shear wave splitting that have been observed in the D" layer by lattice preferred orientation (LPO) of the pPv phase as a result of deformation. However, the dominant shear plane and Burgers vector of the pPv phase are still controversial, partly because of the extremely high pressures that make experimental studies difficult. Thus, controlled strain rate experiments up to a high finite strain are necessary to clarify the development of LPO and thus to interpret seismic data. CaIrO3 is a well-suited analogue for MgSiO3 Pv and pPv phase, since at room P CaIrO3 is isostructural with the pPv phase but undergoes a phase transition to the Pv structure at high T conditions >1450°C. We have performed deformation experiments at P = 1-3 GPa and T = 1000-1450°C with the deformation-DIA multi anvil apparatus using both in the Pv and the pPv stability field to investigate the development of LPO in CaIrO3. While the Pv modification showed only weak or no LPO in pure shear deformation, the pPv modification developed a strong LPO consistent with deformation by intracrystalline slip on the (010)[100] slip system. In TEM analysis of the deformed pPv samples, abundant [100] dislocations were identified. Some of the [100] dislocations having an edge character were also activated on the (010) plane during the deformation experiments. The dislocation microstructures suggest that the (010) plane is a potential slip plane, consistent with the LPO in the deformed samples. The lack of LPO of the Pv modification (analogue for the lower mantle) and the strong LPO of the deformed pPv modification (analogue for D") agree well with the known seismic properties of the lower mantle and the D" layer.

  11. Characterization of virulent Listeria monocytogenes isolates recovered from ready-to-eat meat products and consumers in Cairo, Egypt

    Directory of Open Access Journals (Sweden)

    Maysa A. I. Awadallah

    2014-10-01

    Full Text Available Aim: This study aimed to investigate the occurrence of some virulence genes distributed in Listeria monocytogenes isolated from ready-to-eat (RTE meat products and consumers in Cairo province, Egypt. Materials and Methods: A total of 120 beef luncheon, chicken luncheon and frankfurter beef (40 samples, each were collected from 10 different local shops situated in Al-salam city, Cairo province, Egypt. Stool samples were collected from 40 people who had the habit of consuming RTE meat. The suspected L. monocytogenes isolates were subjected to a multiplex polymerase chain reaction (PCR for rapid speciation and virulence determination using primers specific for inIA, inIC, and inIJ genes. Results: Culture examination of all samples on Oxford media revealed presence of colonies characteristic to L. monocytogenes in 6 beef luncheon (15%, 4 chicken luncheon (10%, 1 frankfurter beef (2.5% and 1 human stool (2.5% samples. Species identity of L. monocytogenes was verified through the amplification of a 800 bp fragment with inIA primers in 2 out of 6 culture isolates from beef luncheon (5%, and 1 out 4 culture isolates from chicken luncheon (2.5% samples. Statistical analysis revealed no significant difference between the occurrence of L. monocytogenes in different food samples examined (p>0.05. The virulence of these strains was ascertained by the presence of 517 bp and 238 bp fragments of inIC and inIJ genes, respectively in the isolates that contained the 800 bp fragment. The culture isolates obtained from one frankfurter beef sample, and one human stool sample were found negative by multiplex PCR for the presence of L. monocytogenes and its virulence specific genes. Conclusion: It could be concluded that L. monocytogenes are circulating in beef and chicken luncheon sold in Cairo, Egypt. Multiplex PCR is reliable for confirmation of L. monocytogenes. This study suggests the implementation of hygienic measures at all levels from production to consumption

  12. Predictive value of MTT assay as an in vitro chemosensitivity testing for gastric cancer: One institution's experience

    Institute of Scientific and Technical Information of China (English)

    Bin Wu; Jin-Shui Zhu; Yi Zhang; Wei-Ming Shen; Qiang Zhang

    2008-01-01

    AIM: To investigate the predictive clinical value of in vitro 3-(4,5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay for directing chemosensitivity in patients with gastric cancer.METHODS: Results of a total of 353 consecutive patients with gastric cancer treated with MTT-directed chemotherapy or physician's empirical chemotherapy from July 1997 to April 2003 were reviewed and analyzed retrospectively.RESULTS: The overall 5-year survival rate of MTTsensitive group (MSG) and control group (CG) was 47.5% and 45.1%, respectively. The results of subgroup analysis with Cox proportional-hazards model were favorable for the MSG-sensitive group. However, no statistically significant difference in survival rate was observed between the two groups.CONCLUSION: Individualized chemotherapy based on in vitro MTT assay is beneficial, but needs to be confirmed by further randomized controlled trials.

  13. Impact of oxaliplatin-induced neuropathy in patients with colorectal cancer: a prospective evaluation at a single institution

    Science.gov (United States)

    Dault, R.; Rousseau, M.P.; Beaudoin, A.; Frenette, M.A.; Lemay, F.; Beauchesne, M.F.

    2016-01-01

    Oxaliplatin plays a major role in the treatment of colorectal cancer (crc), but is associated with the development of neuropathies. The main objective of the present prospective study was to estimate the proportion of participants with grade 1, 2, 3, or 4 peripheral sensory neuropathies according to the U.S. National Cancer Institute’s Common Terminology Criteria for Adverse Events (version 4) among crc patients treated with oxaliplatin (adjuvant or metastatic, folfox or xelox regimens) at the Centre hospitalier universitaire de Sherbrooke. Among the 57 patients so treated between May 2012 and April 2013, about 60% reported grade 2 neuropathy, at maximum, during treatment. About 25% of patients had to stop treatment because of neuropathies. In a subset of patients contacted approximately 22 months after treatment cessation, neuropathies persisted in 70%. Oxaliplatin-induced neuropathy affects a significant number of crc patients and can influence the course of treatment and outcomes. PMID:26966415

  14. From single-gene to multiplex analysis in lung cancer, challenges and accomplishments: a review of a single institution's experience

    OpenAIRE

    Zhao, Weiqiang; Damodaran, Senthilkumar; Villalona-Calero, Miguel A.

    2014-01-01

    Molecular selection has led to the successful use of novel tyrosine kinase inhibitors (TKIs) in non-small-cell lung cancers (NSCLCs). For instance, mutations in EGFR and translocations and fusions in ALK render tumor cells sensitive to some TKIs, leading to substantial clinical benefits. Molecular testing such as DNA sequencing or fragment analysis following PCR, and evaluation of copy number and gene positioning by FISH, have been developed and used clinically to identify mutations/fusions. ...

  15. Locoregional recurrence of triple-negative breast cancer: effect of type of surgery and adjuvant postoperative radiotherapy

    Directory of Open Access Journals (Sweden)

    Bayoumi Y

    2014-09-01

    Full Text Available Yasser Bayoumi,1 Ayman AbdelSamie,2 Ahmed Abdelsaid,3 Aida Radwan4 1Radiation Oncology, 2Medical Oncology, 3Surgical Oncology, 4Medical Physics, National Cancer Institute, Cairo University, Cairo, Egypt Background/purpose: The aim was to evaluate the prognostic significance of postoperative radiotherapy (PORT and surgical type on local recurrence-free survival (LRFS and overall survival (OS in triple-negative breast cancer (TNBC in the Egyptian population. Patients and methods: We evaluated 111 patients with stage I–III TNBC diagnosed at our institute during the period from 2004 to 2009. Patients were stratified according to PORT into two groups: a PORT group and a non-PORT group. The influence of PORT and surgical type on LRFS and OS were evaluated. A cross-matching was done to the non-TNBC group of patients to compare the recurrence and survival rates between them and the studied group of TNBC patients. Results: The mean age of TNBC patients at diagnosis was 63±7 years. The majority of the patients had stage III disease (68.5% and 73% had clinical or pathological positive lymph nodes. Sixty percent (67/111 of patients had modified radical mastectomy and 44/111 (40% patients had breast-conserving treatment. PORT was given for 63% of patients, while systemic treatment was given in 89% of patients. At the time of analysis, 13 patients (11% developed local recurrence: five of 70 (7% in the PORT group and eight of 41 (19.5% in the non-PORT group. Five-year LRFS for the whole group of patients was 88%±6%, which was significantly affected by PORT. The surgical type did not affect local recurrence significantly. Five-year OS for the whole group was 54%±8%. PORT and surgical type did not affect OS significantly (P-value 0.09 and 0.11, respectively. Five-year LRFS was 88%±6% and 90%±11% for TNBC and non-TNBC patients, respectively (P-value 0.8; however, OS for TNBC was significantly lower than for non-TNBC (P-value 0.04. Conclusion: TNBC is an

  16. Changes in the management and survival rates of patients with oral cancer: a 30-year single-institution study

    Science.gov (United States)

    2016-01-01

    Objectives The aim of the present study was to evaluate changes in the management and 5-year survival rates of patients with oral cancer in our department over a 30-year period. Materials and Methods We investigated the patient distributions, treatment methods, method of neck dissection according to cancer stage, and 5-year survival rates for 700 oral cancer patients over the periods of 1982–1996 (256 patients), 1999–2006 (248 patients), and 2007–2011 (196 patients). Results Stage IV patients were the largest group in all of the time periods evaluated. Although surgery and radiotherapy were the most common methods in all periods (over 50%), the prevalence of patients who underwent concomitant chemoradiotherapy increased from 7.0% to 16.2%. The use of radical neck dissection decreased from 43.0% to 5.3%, while conservative surgical methods increased from 24.1% to 76.3%. Lastly, the overall 5-year survival rate increased from 31.6% to 63.5% during the study period. Conclusion Although the 5-year survival rate reached the same level as that of other developed countries during the course of our study, most patients continue to come to the hospital with stage IV disease. In order to increase the 5-year survival rate of oral carcinoma, it may be necessary to improve public education and social efforts relevant to early diagnosis. PMID:26904492

  17. Application of the Western-based adjuvant online model to Korean colon cancer patients; a single institution experience

    International Nuclear Information System (INIS)

    Adjuvant Online (AOL) is web-accessible risk-assessment model that predicts the mortality and the benefits of adjuvant therapy. AOL has never been validated for Asian colon cancer patients. Using the Yonsei Tumor Registry database, patients who were treated within the Yonsei University Health System between 1990 and 2005 for T1-4, N0-2, and M0 colon cancer were included in the calculations for survival. Observed and predicted 5-year overall survival was compared for each patient. The median age of the study population of 1431 patients was 60 years (range, 15–87 years), and the median follow-up duration was 7.9 years (range, 0.06–19.8 years). The predicted 5-year overall survival rate (77.7%) and observed survival (79.5%) was not statistically different (95% Confidential interval, 76.3–81.5) in all patients. Predicted outcomes were within 95% confidential interval of observed survival in both stage II and III disease, including most demographic and pathologic subgroups. Moreover, AOL more accurately predicted OS for patients with stage II than stage III. AOL tended to offer reliable prediction for 5-year overall survival and could be used as a decision making tool for adjuvant treatment in Korean colon cancer patients whose prognosis is similar to other Asian patients

  18. Evaluation of nephron sparing surgery for renal tumors: a single institution experience%肾脏肿瘤保留肾单位手术的评价:单一机构的经验

    Institute of Scientific and Technical Information of China (English)

    Hytham Abd-elkareem Ahmed; Abdelhamid Hussein Ezzat; Ismael Mourad

    2011-01-01

    Objective: The aim of the study was to report the experience of National Cancer Institute (NCI), Cairo University, Egypt, in managing various benign and malignant renal tumors with nephron sparing surgery (NSS), and to assess its safety and feasibility. Methods: Reviewing the literature for NSS, and records of patients who underwent NSS in the period from January 2000 to December 2009 at National Cancer Institute, Cairo University regarding the patient and tumor related characteristics, the indication for NSS, operative technique, postoperative complications, full histopathological data, and follow up results. Results: The total number of patients was 17. Mean age at surgery was 30.7 years (range 1.5-65 years). Five patients had bilateral tumors during surgery. The mean tumor size was 4.5 cm (range 1-9 cm). All patients had normal preoperative kidney functions. Seven patients had an absolute indication for NSS, 6 patients had a relative indication, and 4 patients had an elective indication. All the 5 patients with bilateral tumors underwent bilateral simultaneous surgery. Cold ischemia was used in 8 patients, 1 patient was exposed to warm ischemia, manual compression was used in 2 patients, and no vascular control was applied in 6 patients. Complications were encountered in 2 patients, one of them had urinary leakage which needed reoperation, and the other had subcutaneous hematoma which was treated conservatively. Histopathological analysis revealed Wilm's tumor (8 patients), angiomyolipoma (4 patients), renal cell carcinoma (4 patients), and hydatid cyst (1 patient). All patients had negative surgical margin. For patients with Wilm's tumor, the mean follow up was 21.4 months (range 0-94 months), 2 patients had local recurrence, and 1 patient had distant metastasis. For patients with RCC, the mean follow up was 15.3 months (5-33 months), no patients had local recurrence or distant metastasis. All patients had normal kidney functions during postoperative and follow

  19. Resonant X-ray Diffraction Study of the Strongly Spin-Orbit-Coupled Mott Insulator CaIrO3

    Science.gov (United States)

    Ohgushi, Kenya; Yamaura, Jun-ichi; Ohsumi, Hiroyuki; Sugimoto, Kunihisa; Takeshita, Soshi; Tokuda, Akihisa; Takagi, Hidenori; Takata, Masaki; Arima, Taka-hisa

    2013-05-01

    We performed resonant x-ray diffraction experiments at the L absorption edges for the post-perovskite-type compound CaIrO3 with a (t2g)5 electronic configuration. By observing the magnetic signals, we could clearly see that the magnetic structure was a striped ordering with an antiferromagnetic moment along the c axis and that the wave function of a t2g hole is strongly spin-orbit entangled, the Jeff=1/2 state. The observed spin arrangement is consistent with theoretical work predicting a unique superexchange interaction in the Jeff=1/2 state and points to the universal importance of the spin-orbit coupling in Ir oxides, independent of the octahedral connectivity and lattice topology. We also propose that nonmagnetic resonant scattering is a powerful tool for unraveling an orbital state even in a metallic iridate.

  20. Crystal structure of post-perovskite-type CaIrO3 reinvestigated: new insights into atomic thermal vibration behaviors

    OpenAIRE

    Nakatsuka, Akihiko; Sugiyama, Kazumasa; Yoneda, Akira; Fujiwara, Keiko; Yoshiasa, Akira

    2015-01-01

    Single crystals of the title compound, the post-perovskite-type CaIrO3 [calcium iridium(IV) trioxide], have been grown from a CaCl2 flux at atmospheric pressure. The crystal structure consists of an alternate stacking of IrO6 octa­hedral layers and CaO8 hendeca­hedral layers along [010]. Chains formed by edge-sharing of IrO6 octa­hedra (point-group symmetry 2/m..) run along [100] and are inter­connected along [001] by sharing apical O atoms to build up the IrO6 octa­hedral layers. Chains form...

  1. Performance and main characteristic parameters of the Cairo fourier diffractometer facility at the ET-RR-1 reactor

    International Nuclear Information System (INIS)

    This report represents the results of measurements performed recently with the Cairo Fourier diffractometer facility (CFDF). The main components of the CFDF were supplied by the IAEA according to the technical assistance project EGY/1/022. The CFDF performance is assessed and the main parameters are given. The neutron guide system attached to the CFDF provides a thermal neutron flux ∼ 106n/cm2.sec at the sample position; free from fast neutrons and gamma rays background. It has been found, from measurements with different powder samples, that such value of the thermal neutron flux is adequate for neutron diffraction measurements, at scattering angle 2θ 90 deg. and D values between 0.7A and 2.5A; with 52% resolution. (author). 26 refs, 10 figs, 2 tabs

  2. The nonmedical use of psychoactive substances by male technical school students in Greater Cairo: an epidemiological study.

    Science.gov (United States)

    Soueif, M I; Darweesh, Z A; Hannourah, M A; El-Sayed, A M

    1982-12-01

    This is the second of a series of studies planned to explore the epidemiology of nonmedical use of drugs among Egyptian youth. A standardized questionnaire with well established reliability and validity estimates was administered to a representative sample of technical school students in Greater Cairo, numbering 3686 male pupils. The questionnaire was designed to shed light on the extent of use of nonmedical drugs plus the aetiology of such use. Among the interesting findings are the following: about 5% of the students tried at least one type of synthetic drugs; slightly over 11% tried narcotics and 33% used alcohol at least once. In all cases of 'ever using' drugs those who stopped the practice were mainly motivated by fear of expected physical as well as psychological harm. An attempt was made to shed light on psychosocial factors contributing to the actual initiation of drug use as well as to being prone to such use. PMID:7166142

  3. Study of the formation of the ``Black Cloud'' and its dynamics over Cairo, Egypt using MODIS and MISR sensors

    Science.gov (United States)

    Marey, H. S.; Gille, J. C.; El-Askary, H. M.; Shalaby, E. A.; El-Raey, M. E.

    2010-12-01

    In the last decade, episodes of severe air pollution, known as the “black cloud”, have occurred in Cairo, Egypt in the early autumn. In this study data from the Moderate Resolution Imaging Spectrometer (MODIS) and the Multi-angle Imaging SpectroRadiometer (MISR) are used with meteorological data and trajectory analyses to determine the cause of these events. MODIS fire counts put the source as the burning of agricultural waste after harvest season in the Nile delta region. Synchronous MISR data show that these fires create low altitude (burning occurs at night, when an inversion constrains the plumes to remain in the boundary layer (BL). Convection during the day raises the BL, dispersing these smoke particles until the next night. The spatial distribution of fire points over the Nile delta for September and October 2006, green square represents the Nile delta area. Monthly average fire counts over Nile delta from 2002-2009

  4. Whole-Pelvis or Bladder-Only Chemoradiation for Lymph Node–Negative Invasive Bladder Cancer: Single-Institution Experience

    International Nuclear Information System (INIS)

    Purpose: Whole-pelvis (WP) concurrent chemoradiation (CCRT) is the standard bladder preserving option for patients with invasive bladder cancer. The standard practice is to treat elective pelvic lymph nodes, so our aim was to evaluate whether bladder-only (BO) CCRT leads to results similar to those obtained by standard WP-CCRT. Methods and Materials: Patient eligibility included histopathologically proven muscle-invasive bladder cancer, lymph nodes negative (T2–T4, N−) by radiology, and maximal transurethral resection of bladder tumor with normal hematologic, renal, and liver functions. Between March 2005 and May 2006, 230 patients were accrued. Patients were randomly assigned to WP-CCRT (120 patients) and BO-CCRT (110 patients). Data regarding the toxicity profile, compliance, initial complete response rates at 3 months, and occurrence of locoregional or distant failure were recorded. Results: With a median follow-up time of 5 years (range, 3–6), WP-CCRT was associated with a 5-year disease-free survival of 47.1% compared with 46.9% in patients treated with BO-CCRT (p = 0.5). The bladder preservation rates were 58.9% and 57.1% in WP-CCRT and BO-CCRT, respectively (p = 0.8), and the 5-year overall survival rates were 52.9% for WP-CCRT and 51% for BO-CCRT (p = 0.8). Conclusion: BO-CCRT showed similar rates of bladder preservation, disease-free survival, and overall survival rates as those of WP-CCRT. Smaller field sizes including bladder with 2-cm margins can be used as bladder preservation protocol for patients with muscle-invasive lymph node–negative bladder cancer to minimize the side effects of CCRT.

  5. Enteral Feeding During Chemoradiotherapy for Advanced Head-and-Neck Cancer: A Single-Institution Experience Using a Reactive Approach

    International Nuclear Information System (INIS)

    Purpose: The optimal method for providing enteral nutrition to patients with head-and-neck cancer is unclear. The purpose of the present study was to evaluate the safety and efficacy of our reactive policy, which consists of the installation of a nasogastric (NG) feeding tube only when required by the patient's nutritional status. Methods and Materials: The records of all patients with Stage III and IV head-and-neck cancer treated with concomitant chemotherapy and radiotherapy between January 2003 and December 2006 were reviewed. The overall and disease-free survival rates were estimated using the Kaplan-Meier method and compared with the log-rank test. Results: The present study included 253 patients, and the median follow-up was 33 months. At 3 years, the estimated overall survival and disease-free survival rate was 82.8% and 77.8%, respectively, for the whole population. No survival difference was observed when the patients were compared according to the presence and absence of a NG tube or stratified by weight loss quartile. The mean weight loss during treatment for all patients was 10.4%. The proportion of patients requiring a NG tube was 49.8%, and the NG tube remained in place for a median duration of 40 days. No major complications were associated with NG tube installation. Only 3% of the patients were still dependent on enteral feeding at 6 months. Conclusion: These results suggest that the use of a reactive NG tube with an interdisciplinary team approach is a safe and effective method to manage malnutrition in patients treated with concomitant chemotherapy and radiotherapy for head-and-neck cancer.

  6. Environmental and Occupational Lead Exposure Among Children in Cairo, Egypt: A Community-Based Cross-Sectional Study.

    Science.gov (United States)

    Moawad, Eman Mohamed Ibraheim; Badawy, Nashwa Mostafa; Manawill, Marie

    2016-03-01

    The aim of this study was to assess childhood lead exposure in a representative sample of Cairo, and to investigate the possible risk factors and sources of exposure. This cross-sectional study was conducted from November 2014 through April 2015. The target population was children aged 6 to 18 years, recruited into 4 groups, garbage city, moderate-living standard area, urban and suburban schools, and workshops in the city of Cairo. Blood lead levels (BLLs) and hemoglobin (Hb) concentrations were measured. Also, potential local environmental sources were assessed for hazardous lead contamination. Analysis on 400 participants has been carried out. A total of 113 children had BLLs in the range 10 to 20 μg/dL. Smoking fathers, housing conditions, playing outdoors, and exposure to lead in residential areas were significantly correlated with high BLLs. The mean values of hemoglobin were inversely correlated with BLLs. Children involved in pottery workshops had the highest BLLs and the lowest Hb values with a mean of (43.3 μg/dL and 8.6 g/dL, respectively). The mean value of environmental lead in workshop areas exceeded the recommended levels. Also, those values measured in dust and paint samples of garbage city were significantly high. Moreover, the mean lead levels in the soil samples were significantly higher in urban schools (P = 0.03) than the suburban ones. Childhood lead poisoning accounts for a substantial burden in Egypt, which could be preventable. Development of national prevention programs including universal screening program should be designed to reduce incidence of lead toxicity among children. PMID:26945415

  7. Morbidity associated to the transfusion support in pediatric patients with acute leukemia in the National Cancer Institute

    International Nuclear Information System (INIS)

    Acute leukemia represents the most common cancer in pediatrics. The current treatments made necessary a hematological support which increases the risks of complications, like fever, immunologic reaction, infections and, graft versus host disease. The objective of the present study was to determine the morbidity associated with transfusion support in pediatric patients with acute leukemia. In the pediatric population with diagnosis of acute leukemia in the INC during one and half year, the morbidity associated with transfusions was low and couldn't be related to the treatment given to the transfused products

  8. Cancer of Unknown Primary Site:A Review of 28 Cases and the Efficacy of Cisplatin/Docetaxel Therapy at a Single Institute in Japan

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    Nishimori,Hisakazu

    2010-10-01

    Full Text Available We evaluated the efficacy and toxicity of cisplatin/docetaxel (CDDP/TXT chemotherapy and identified prognostic factors in Japanese patients with cancer of unknown primary site (CUP. Twenty-eight consecutive patients seen at a single institute were reviewed retrospectively. Sixteen patients were treated with TXT 80mg/m2, followed by CDDP 75mg/m2. The overall response rate to CDDP/TXT treatment was 62.5%, with a median survival time (MST of 22.7 months. Common adverse reactions were myelosuppression and hyponatremia. The MST of all 28 patients with CUP was 8.3 months, and the 1-year overall survival rate was 45.6%. Univariate analysis identified 5 prognostic factors:performance status, liver involvement, bone involvement, pleural involvement, and lymph node involvement. In conclusion, CDDP/TXT chemotherapy is effective with tolerable toxicity in patients with CUP. Japanese patients with CUP might be chemosensitive and may survive longer.

  9. Survival of Mexican Children with Acute Lymphoblastic Leukaemia under Treatment with the Protocol from the Dana-Farber Cancer Institute 00-01

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    Elva Jiménez-Hernández

    2015-01-01

    Full Text Available Our aim in this paper is to describe the results of treatment of acute lymphoblastic leukaemia (ALL in Mexican children treated from 2006 to 2010 under the protocol from the Dana-Farber Cancer Institute (DFCI 00-01. The children were younger than 16 years of age and had a diagnosis of ALL de novo. The patients were classified as standard risk if they were 1–9.9 years old and had a leucocyte count 100 × 109/L. The poor outcomes were associated with toxic death during induction, complete remission, and relapse. These factors remain the main obstacles to the success of this treatment in our population.

  10. Biweekly cetuximab and irinotecan in advanced colorectal cancer patients progressing after at least one previous line of chemotherapy: results of a phase II single institution trial

    Science.gov (United States)

    Martín-Martorell, P; Roselló, S; Rodríguez-Braun, E; Chirivella, I; Bosch, A; Cervantes, A

    2008-01-01

    This is a phase II institutional exploratory trial of biweekly irinotecan and cetuximab administration regimen in metastatic colorectal cancer patients progressing to at least one previous chemotherapy line. A total of 40 patients were treated between November 2005 and November 2007 with irinotecan 180 mg m−2 and cetuximab 500 mg m−2 q2w (every 2 weeks), in every 21-day cycles, until unacceptable toxicity or progressive disease. An overall response rate of 22.5% was obtained (two complete and seven partial responses). The disease control rate was 60%. The time to progression was 3.4 months and the overall survival was 8 months. The toxicity compared very favourably to weekly cetuximab combination schedules. Grade 3/4 adverse effects were observed in 12 patients. Overall, our results turn up very similar both in terms of toxicity and efficacy to those obtained by weekly and biweekly administration regimens. PMID:18665167

  11. Prostate cancer - treatment

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000403.htm Prostate cancer - treatment To use the sharing features on this ... a combination of drugs is recommended. References National Cancer Institute. Prostate cancer treatment (PDQ): Stages of prostate cancer. Updated ...

  12. Cervical Cancer Stage IVB

    Science.gov (United States)

    ... of the body, such as the lymph nodes, lung, liver, intestine, or bone. Stage IVB cervical cancer. Topics/Categories: Anatomy -- Gynecologic Cancer Types -- Cervical Cancer Staging Type: Color, Medical Illustration Source: National Cancer Institute ...

  13. Study On The Prevalence Of Various Forms Of Cancer In Diabetic Patients Hospitalized In The National Institute Of Diabetes, Nutrition And Metabolic Diseases “Prof. N.C. Paulescu”

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    Popescu-Vâlceanu Horaţiu-Cristian

    2015-06-01

    Full Text Available Background and aims: Epidemiological evidence suggests that people with diabetes have a significantly increased risk of developing various cancers. The aim of the study was to assess the frequency of various cancers in diabetic patients admitted in the National Institute of Diabetes Nutrition and Metabolic Diseases “Prof. N.C. Paulescu” between 01.01.2011 and 01.09.2014.

  14. Stereotactic Ablative Radiation Therapy as First Local Therapy for Lung Oligometastases From Colorectal Cancer: A Single-Institution Cohort Study

    Energy Technology Data Exchange (ETDEWEB)

    Filippi, Andrea Riccardo, E-mail: andreariccardo.filippi@unito.it [Department of Oncology, Radiation Oncology, University of Torino, Torino (Italy); Badellino, Serena [Department of Oncology, Radiation Oncology, University of Torino, Torino (Italy); Ceccarelli, Manuela [Cancer Epidemiology and CPO Piemonte, Città della Salute e della Scienza, Torino (Italy); Guarneri, Alessia [Radiation Oncology, Città della Salute e della Scienza, Torino (Italy); Franco, Pierfrancesco [Department of Oncology, Radiation Oncology, University of Torino, Torino (Italy); Monagheddu, Chiara [Cancer Epidemiology and CPO Piemonte, Città della Salute e della Scienza, Torino (Italy); Spadi, Rosella [Medical Oncology, Colorectal Cancer Unit, Città della Salute e della Scienza, Torino (Italy); Ragona, Riccardo [Department of Oncology, Radiation Oncology, University of Torino, Torino (Italy); Racca, Patrizia [Medical Oncology, Colorectal Cancer Unit, Città della Salute e della Scienza, Torino (Italy); Ricardi, Umberto [Department of Oncology, Radiation Oncology, University of Torino, Torino (Italy)

    2015-03-01

    Purpose: To estimate stereotactic ablative radiation therapy (SABR) efficacy and its potential role as an alternative to surgery for the treatment of lung metastases from colorectal cancer. Methods and Materials: Forty consecutive patients who received SABR as first local therapy at the time of lung progression were included, from 2004 to 2014. The primary study endpoint was overall survival. Secondary endpoints were progression-free survival and safety. Results: A single nodule was treated in 26 patients (65%), 2 nodules in 10 patients (25%), 3 in 3 patients (7.5%), and 4 in 1 patient (2.5%), for a total of 59 lesions. The median delivered biological effective dose was 96 Gy, in 1 to 8 daily fractions. Median follow-up time was 20 months (range, 3-72 months). Overall survival rates at 1, 2, and 5 years were, respectively, 84%, 73%, and 39%, with 14 patients (35%) dead. Median overall survival was 46 months. Progression occurred in 25 patients (62.5%), at a median interval of 8 months; failure at SABR site was observed in 3 patients (7.5%). Progression-free survival rates were 49% and 27% at 1 and 2 years, respectively. Discussion: The results of this retrospective exploratory analysis suggest safety and efficacy of SABR in patients affected with colorectal cancer lung oligometastases and urge inclusion of SABR in prospective clinical trials.

  15. Uncertainties of target volume delineation in MRI guided adaptive brachytherapy of cervix cancer: A multi-institutional study

    International Nuclear Information System (INIS)

    Background and aim: We aimed to quantify target volume delineation uncertainties in cervix cancer image guided adaptive brachytherapy (IGABT). Materials and methods: Ten radiation oncologists delineated gross tumour volume (GTV), high- and intermediate-risk clinical target volume (HR CTV, IR CTV) in six patients. Their contours were compared with two reference delineations (STAPLE-Simultaneous Truth and Performance Level Estimation and EC- expert consensus) by calculating volumetric and planar conformity index (VCI and PCI) and inter-delineation distances (IDD). Results: VCISTAPLE and VCIEC were 0.76 and 0.72 for HR CTV, 0.77 and 0.68 for IR CTV and 0.59 and 0.58 for GTV. Variation was most prominent caudally and cranially in all target volumes and posterolaterally in IR CTV. IDDSTAPLE and IDDEC for HR CTV (3.6 ± 3.5 and 3.8 ± 3.4 mm) were significantly lower than for GTV (4.8 ± 4.2 and 4.2 ± 3.5 mm) and IR CTV (4.7 ± 5.2 and 5.2 ± 5.6 mm) (p < 0.05). Conclusions: Due to lower delineation uncertainties when compared to GTV and IR CTV, HR CTV may be considered most robust volume for dose prescription and optimization in cervix cancer IGABT. Adequate imaging, training and use of contouring recommendations are main strategies to minimize delineation uncertainties

  16. Stereotactic Ablative Radiation Therapy as First Local Therapy for Lung Oligometastases From Colorectal Cancer: A Single-Institution Cohort Study

    International Nuclear Information System (INIS)

    Purpose: To estimate stereotactic ablative radiation therapy (SABR) efficacy and its potential role as an alternative to surgery for the treatment of lung metastases from colorectal cancer. Methods and Materials: Forty consecutive patients who received SABR as first local therapy at the time of lung progression were included, from 2004 to 2014. The primary study endpoint was overall survival. Secondary endpoints were progression-free survival and safety. Results: A single nodule was treated in 26 patients (65%), 2 nodules in 10 patients (25%), 3 in 3 patients (7.5%), and 4 in 1 patient (2.5%), for a total of 59 lesions. The median delivered biological effective dose was 96 Gy, in 1 to 8 daily fractions. Median follow-up time was 20 months (range, 3-72 months). Overall survival rates at 1, 2, and 5 years were, respectively, 84%, 73%, and 39%, with 14 patients (35%) dead. Median overall survival was 46 months. Progression occurred in 25 patients (62.5%), at a median interval of 8 months; failure at SABR site was observed in 3 patients (7.5%). Progression-free survival rates were 49% and 27% at 1 and 2 years, respectively. Discussion: The results of this retrospective exploratory analysis suggest safety and efficacy of SABR in patients affected with colorectal cancer lung oligometastases and urge inclusion of SABR in prospective clinical trials

  17. Cross-cultural Adaptation of the EORTC QLQ CR-29 Questionnaire for Use in Colorectal Cancer Patients at the National Cancer Institute of Colombia

    International Nuclear Information System (INIS)

    Objective: To validate a cross-cultural version of the EORTC QLQ CR-29 questionnaire version 2.0 (neutral Spanish) for use in Colombian patients. Methods: The EORTC quality of life group algorithm was applied including translation, translation comparison, reverse translation, and pilot application of the questionnaire. Results: The terms used to define the answers across items were modified. In four items the instrument was also modified using different words. The pilot verified a better understanding after the changes. Conclusions: An adapted version of the EORTC QLQ CR-29 is available for Colombia. Thus, validation of psychometric properties through its application in colorectal cancer patients is currently suitable.

  18. The challenge to bring personalized cancer medicine from clinical trials into routine clinical practice: the case of the Institut Gustave Roussy.

    Science.gov (United States)

    Arnedos, Monica; André, Fabrice; Farace, Françoise; Lacroix, Ludovic; Besse, Benjamin; Robert, Caroline; Soria, Jean Charles; Eggermont, Alexander M M

    2012-04-01

    Research with high throughput technologies has propitiated the segmentation of different types of tumors into very small subgroups characterized by the presence of very rare molecular alterations. The identification of these subgroups and the apparition of new agents targeting these infrequent alterations are already affecting the way in which clinical trials are being conducted with an increased need to identify those patients harboring specific molecular alterations. In this review we describe some of the currently ongoing and future studies at the Institut Gustave Roussy that aim for the identification of potential therapeutic targets for cancer patients with the incorporation of high throughput technologies into daily practice including aCGH, next generation sequencing and the creation of a software that allows for target identification specific for each tumor. The initial intention is to enrich clinical trials with cancer patients carrying certain molecular alterations in order to increase the possibility of demonstrating benefit from a targeted agent. Mid and long term aims are to facilitate and speed up the process of drug development as well as to implement the concept of personalized medicine. PMID:22483534

  19. Virtual Screening of Specific Insulin-Like Growth Factor 1 Receptor (IGF1R Inhibitors from the National Cancer Institute (NCI Molecular Database

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    Yu-Xin Li

    2012-12-01

    Full Text Available Insulin-like growth factor 1 receptor (IGF1R is an attractive drug target for cancer therapy and research on IGF1R inhibitors has had success in clinical trials. A particular challenge in the development of specific IGF1R inhibitors is interference from insulin receptor (IR, which has a nearly identical sequence. A few potent inhibitors that are selective for IGF1R have been discovered experimentally with the aid of computational methods. However, studies on the rapid identification of IGF1R-selective inhibitors using virtual screening and confidence-level inspections of ligands that show different interactions with IGF1R and IR in docking analysis are rare. In this study, we established virtual screening and binding-mode prediction workflows based on benchmark results of IGF1R and several kinase receptors with IGF1R-like structures. We used comprehensive analysis of the known complexes of IGF1R and IR with their binding ligands to screen specific IGF1R inhibitors. Using these workflows, 17 of 139,735 compounds in the NCI (National Cancer Institute database were identified as potential specific inhibitors of IGF1R. Calculations of the potential of mean force (PMF with GROMACS were further conducted for three of the identified compounds to assess their binding affinity differences towards IGF1R and IR.

  20. Whole brain radiotherapy with a conformational external beam radiation boost for lung cancer patients with 1-3 brain metastasis: a multi institutional study

    International Nuclear Information System (INIS)

    To determine the outcome of patients with brain metastasis (BM) from lung cancer treated with an external beam radiotherapy boost (RTB) after whole brain radiotherapy (WBRT). A total of 53 BM patients with lung cancer were treated sequentially with WBRT and RTB between 1996 and 2008 according to our institutional protocol. Mean age was 58.8 years. The median KPS was 90. Median recursive partitioning analysis (RPA) and graded prognostic assessment (GPA) grouping were 2 and 2.5, respectively. Surgery was performed on 38 (71%) patients. The median number of BM was 1 (range, 1-3). Median WBRT and RTB combined dose was 39 Gy (range, 37.5 - 54). Median follow-up was 12.0 months. During the period of follow-up, 37 (70%) patients died. The median overall survival (OS) was 14.5 months. Only 13 patients failed in the brain. The majority of patients (n = 29) failed distantly. The 1-year OS, -local control, extracranial failure rates were 61.2%, 75.2% and 60.8%, respectively. On univariate analysis, improved OS was found to be significantly associated with total dose (≤ 39 Gy vs. > 39 Gy; p < 0.01), age < 65 (p < 0.01), absence of extracranial metastasis (p < 0.01), GPA ≥ 2.5 (p = 0.01), KPS ≥ 90 (p = 0.01), and RPA < 2 (p = 0.04). On multivariate analysis, total dose (p < 0.01) and the absence of extracranial metastasis (p = 0.03) retained statistical significance. The majority of lung cancer patients treated with WBRT and RTB progressed extracranially. There might be a subgroup of younger patients with good performance status and no extracranial disease who may benefit from dose escalation after WBRT to the metastatic site

  1. Breast cancer in malaysia: are our women getting the right message? 10 year-experience in a single institution in Malaysia.

    Science.gov (United States)

    Taib, Nur Aishah; Yip, Cheng Har; Ibrahim, Mohamed; Ng, C J; Farizah, H

    2007-01-01

    The message that health care providers caring for patients with breast cancer would like to put forth, is that, not only early detection is crucial but early treatment too is important in ensuring survival. This paper examines the pattern of presentation at a single institution over a 10-year period from 1995 to 2005. In Malaysia, education outreach programmes are ongoing, with contributions not only from the public sector, but also private enterprise. Articles on breast cancer in local newspapers and women magazines and television are quite commonplace. However are our women getting the right message? Now is an appropriate time to bring the stakeholders together to formulate a way to reach all women in Malaysia, not excluding the fact that we are from different races, different education levels and backgrounds requiring differing ways of delivering health promotion messages. To answer the question of why women present late, we prospectively studied 25 women who presented with locally advanced disease. A quantitative, quasi-qualitative study was embarked upon, as a prelude to a more detailed study. Reasons for presenting late were recorded. We also looked at the pattern of presentation of breast lumps in women to our breast clinic in UMMC and in the surgical clinic in Hospital Kota Bharu, in the smaller capital of the state of Kelantan, in 2003. There is hope for the future, the government being a socially responsible one is currently making efforts towards mammographic screening in Malaysia. However understanding of the disease, acceptance of medical treatment and providing resources is imperative to ensure that health behaviour exhibited by our women is not self-destructive but self-preserving. Women are an integral part of not only the nation's workforce but the lifeline of the family - hopefully in the next decade we will see great improvement in the survival of Malaysian women with breast cancer. PMID:17477791

  2. Commentary on "Reproductive factors and kidney cancer risk in 2 US cohort studies, 1993-2010." Karami S, Daugherty SE, Schonfeld SJ, Park Y, Hollenbeck AR, Grubb RL 3rd, Hofmann JN, Chow WH, Purdue MP, Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD. Am J Epidemiol 2013; 177(12):1368-77. [Epub 2013 Apr 26]. doi: 10.1093/aje/kws406.

    Science.gov (United States)

    Boorjian, Stephen

    2014-08-01

    Clinical and experimental findings suggest that female hormonal and reproductive factors could influence kidney cancer development. To evaluate this association, we conducted analyses in 2 large prospective cohorts (the National Institutes of Health-AARP Diet and Health Study (NIH-AARP), 1995-2006, and the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO), 1993-2010). Cohort-specific and aggregated hazard ratios and 95% confidence intervals relating reproductive factors and kidney cancer risk were computed by Cox regression. The analysis included 792 incident kidney cancer cases among 283,952 postmenopausal women. Women who had undergone a hysterectomy were at a significantly elevated kidney cancer risk in both NIH-AARP (hazard ratio = 1.28, 95% confidence interval: 1.09, 1.50) and PLCO (hazard ratio = 1.41, 95% confidence interval: 1.06, 1.88). Similar results were observed for both cohorts after analyses were restricted to women who had undergone a hysterectomy with or without an oophorectomy. For the NIH-AARP cohort, an inverse association was observed with increasing age at menarche (P for trend= 0.02) and increasing years of oral contraceptive use (P for trend = 0.02). No clear evidence of an association with parity or other reproductive factors was found. Our results suggest that hysterectomy is associated with increased risk of kidney cancer. The observed associations with age at menarche and oral contraceptive use warrant further investigation. PMID:25087669

  3. Next-generation sequencing in patients with advanced cancer: are we ready for widespread clinical use? A single institute's experience.

    Science.gov (United States)

    Grenader, Tal; Tauber, Rachel; Shavit, Linda

    2016-10-01

    The next-generation sequencing (NGS) assay targeting cancer-relevant genes has been adopted widely for use in patients with advanced cancer. The primary aim of this study was to assess the clinical utility of commercially available NGS. We retrospectively collected demographic and clinicopathologic data, recommended therapy, and clinical outcomes of 30 patients with a variety of advanced solid tumors referred to Foundation Medicine NGS. The initial pathologic examination was performed at the pathology department of the referring hospital. The comprehensive clinical NSG assay was performed on paraffin-embedded tumor samples using the Clinical Laboratory Improvement Amendments-certified FoundationOne platform. The median number of genomic alterations was 3 (0-19). The median number of therapies with potential benefit was 2 (0-8). In 12 cases, a comprehensive clinical NGS assay did not indicate any therapy with potential benefit according to the genomic profile. Ten of the 30 patients received treatments recommended by genomic profile results. In six of the 10 cases, disease progressed within 2 months and four patients died within 3 months of treatment initiation. Three of the 30 patients benefited from a comprehensive clinical NGS assay and the subsequent recommended therapy. The median PFS was 12 weeks (95% confidence interval 10-57) in patients treated with molecularly targeted agents chosen on the basis of tumor genomic profiling versus 48 weeks (95% confidence interval 8-38) in the control group treated with physician choice therapy (P=0.12). Our study suggests that NGS can detect additional treatment targets in individual patients, but prospective medical research and appropriate clinical guidelines for proper clinical use are vital. PMID:27384593

  4. Best supportive care compared with chemotherapy and radiotherapy for unresectable gallbladder cancer: A tertiary care institute experience

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    Pramod Kumar Singh

    2014-01-01

    Full Text Available Context: Gallbladder represent the most common cancer among biliary tree, complete surgery offers only chance of cure, but most of patients with unresectable or metastatic stage, in such patients only palliative treatment be given. Aims: The aim of this retrospective study is to evaluate efficacy of chemotherapy with gemcitabine and oxaliplatin (GEMOX, and or with radiotherapy over best supportive care (BSC in unresectable gallbladder cancer (GBC. Materials and Methods: Patients with unresectable GBC were evaluated from our center between 2008 and 2011. Three cohorts were identified. Group A, BSC, Group B chemotherapy with GEMOX two weekly for maximum of six cycles. Group C, Chemotherapy with GEMOX and Radiotherapy. Patients underwent percutaneous transhepatic biliary drainage (PTBD or Endoscopic retrograde cholangiopancreatography (ERCP when required. Results: Total 50 patients included in analysis. 19 are male and 31 are female. 14 patients in Group A. 18 patients in Group B and 18 in Group C. Median follow up was 8.8 month. The progression free survival (PFS of patients who received of BSC at 15 month was 18%. PFS of patients who received chemotherapy (CCT at 28 month was 30%. PFS of patients who received CCT Chemotherapy and radiotherapy PFS at 15 month was 38%. When compared all three group none is statically significant (P = 0.538. Conclusion: Judicious used of BSC along with chemotherapy and or with radiotherapy may help in increase in period of stable disease along with overall survival (OS in selected group. In our retrospective analysis CCT with GEMOX and with radiotherapy has helped in improving the OS and PFS in few patients who had good performance status.

  5. Female Breast Cancer: Epidemiological And Clinical Study Of Some Risk Factors Among Egyptian Females- Multi Clinics Study

    OpenAIRE

    E. A. El-Moselhy; M. A. S. Ahmed*; A. M. Abdel-Fattah

    2005-01-01

    This study was conducted on 390 female breast cancer patients and an equal number of females as controls. The patients were attending some University and Teaching Hospitals in Cairo and Assuit. Ninety of them were newly operated. A retrospective, case-control, clinic based study was chosen to carry out this research. The aim of the study was to describe the sociodemographic, characteristics and clinical features of female breast cancer and to determine its risk factors among Egyptian women. A...

  6. Penile primary melanoma: analysis of 6 patients treated at Brazilian national cancer institute in the last eight years

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    Gustavo Ruschi Bechara

    2013-12-01

    Full Text Available Purpose To describe our experience in treating penile melanoma in 06 patients followed at our institution. Materials and Methods Between 2004 and 2012 six consecutive patients with penile melanoma were treated at our Institution. Stage of the disease was classified according to the 2002 AJCC pathologic system. Melanoma in situ (TIS was diagnosed in one patient. One patient was staged as T1b, two patients as T2b and two patients as T4b. The clinical and pathological findings were evaluated. Immunohistochemical tests were performed for Melan-A, HNB-45, S-100 and C-KIT. All histological specimens were examined by the same pathologist (ABSS. The patients with Cis, stages T1b and one patient T2b underwent only local excision. One patient T2b underwent local excision and sentinel lymph node dissection. Two patients with melanoma stage T4b underwent partial penile amputation. One of these last patients had palpable inguinal lymph nodes at diagnosis and underwent bilateral inguinal lymphadenectomy and received systemic chemotherapy (dacarbazine, 30 cycles. Results Mean follow-up was 36.3 months. One patient, with stage T2b, died after 12 months due to disease recurrence with bilateral inguinal involvement. The patient who underwent chemotherapy progressed with lung metastases and died after 14 months of follow up. The disease-free survival at five years was 33.3%. Conclusion: Penile melanoma is a disease with poor prognosis in most cases. Local excision or partial penile amputation may have effective control for stages T1 and T2 lesions. Patients who have clinically proven metastases died despite surgical and adjuvant chemotherapy.

  7. Inter-observer variability of clinical target volume delineation in radiotherapy treatment of pancreatic cancer: a multi-institutional contouring experience

    International Nuclear Information System (INIS)

    An observational multi-institutional study has been conducted aimed to evaluate the inter-observer variability in clinical target volume (CTV) delineation among different radiation oncologists in radiotherapy treatment of pancreatic cancer. A multi-institutional contouring dummy-run of two different cases of pancreatic cancer treated by postoperative and preoperative radiotherapy (RT) was performed. Clinical history, diagnostics, and planning CT imaging were available on AIRO website. Participants were requested to delineate CTVs according to their skills and knowledge. Aiming to quantify interobserver variability of CTVs delineations, the total volume, craniocaudal, laterolateral, and anteroposterior diameters were calculated. Descriptive statistic was calculated. The 95% Confidence Interval (95% CI) for coefficient of variation (CV) was estimated. The Dice Similarity Index (DSI) was used to evaluate the spatial overlap accuracy of the different CTVs compared with the CTVs of a national reference Centre considered as a benchmark. The mean DSI (mDSI) was calculated and reported. A total of 18 radiation oncologists from different Institutes submitted the targets. Less variability was observed for the Elective CTV rather than the Boost CTV, in both cases. The estimated CV were 28.8% (95% CI: 21.2 - 45.0%) and 20.0% (95% CI: 14.9 - 30.6%) for the Elective CTV, in adjuvant (Case 1) and neoadjuvant (Case 2) case, respectively. The mDSI value was 0.68 for the Elective CTVs in both cases (range 0.19 - 0.79 in postoperative vs range 0.35 - 0.79 in preoperative case). The mDSI was increased to 0.71 (Case 1) and 0.72 (Case 2) if the observers with a worse agreement have been excluded. On the other hand, a CV of 42.4% (95% CI: 30.1 - 72.4%) and 63.8% (95% CI: 43.9 - 119.2%) with a mDSI value of 0.44 and 0.52, were calculated for the Boost CTV in Case 1 and Case 2, respectively. The CV and mDSI obtained values for Elective CTVs showed an acceptable agreement among participants

  8. Outcome in Advanced Ovarian Cancer following an Appropriate and Comprehensive Effort at Upfront Cytoreduction: A Twenty-Year Experience in a Single Cancer Institute

    Directory of Open Access Journals (Sweden)

    Anne Marszalek

    2010-01-01

    Full Text Available Objectives. The purpose of this retrospective evaluation of advanced-stage ovarian cancer patients was to compare outcome with published findings from other centers and to discuss future options for the management of advanced ovarian carcinoma patients. Methods. A retrospective series of 340 patients with a mean age of 58 years (range: 17–88 treated for FIGO stage III and IV ovarian cancer between January 1985 and January 2005 was reviewed. All patients had primary cytoreductive surgery, without extensive bowel, peritoneal, or systematic lymph node resection, thereby allowing initiation of chemotherapy without delay. Chemotherapy consisted of cisplatin-based chemotherapy in combination with alkylating agents before 2000, whereas carboplatin and paclitaxel regimes were generally used after 1999-2000. Overall survival and disease-free survival were analyzed by the Kaplan-Meier method and the log-rank test. Results. With a mean followup of 101 months (range: 5 to 203, 280 events (recurrence or death were observed and 245 patients (72% had died. The mortality and morbidity related to surgery were low. The main prognostic factor for overall survival was postoperative residual disease (P<.0002, while the main prognostic factor for disease-free survival was histological tumor type (P<.0007. Multivariate analysis identified three significant risk factors: optimal surgery (RR=2.2 for suboptimal surgery, menopausal status (RR=1.47 for postmenopausal women, and presence of a taxane in the chemotherapy combination (RR=0.72. Conclusion. These results confirm that optimal surgery defined by an appropriate and comprehensive effort at upfront cytoreduction limits morbidity related to the surgical procedure and allows initiation of chemotherapy without any negative impact on survival. The impact of neoadjuvant chemotherapy to improve resectability while lowering the morbidity of the surgical procedure is discussed.

  9. Experimental Investigation Related To Some Predicted Results Of Reliable High Frequency Radio Communication Links Between Benghazi-Libya And Cairo-Egypt.

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    Mohamed Yousef Ahmed Abou-Hussein

    2014-01-01

    Full Text Available In this study, the central radio propagation laboratory (CRPL method of ionospheric prediction of the National Bureau of Standards (NBS in U.S.A was used in practical calculations of the optimal working frequencies for reliable high frequency (HF radio communication links between Benghazi-Libya and Cairo-Egypt. The results were drawn in the form of curves by using the computer. The computer was used to measure the received signal level variation of frequencies 11.980 MHz, 11.785 MHz which were transmitted with a power of 250 KW, 100 KW respectively from the Egypt Arabic Republic Broadcasting station in Cairo city, directed to the North Africa and South Europe regions. The measurements were taken during daytime's for winter (December, January& February and summer (June, July & August seasons.

  10. Feasibility of laparoscopic abdomino - perineal resection for large - sized anorectal cancers : A single - institution experience of 59 cases

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    Shukla Parul

    2009-03-01

    Full Text Available Background: Laparoscopic surgery for anorectal carcinoma is steadily gaining acceptance. While feasibility has already been reported, there are no reports addressing the impact of the actual size of large tumors on laparoscopic resectability . Aim: To assess the feasibility and short-term results (including oncological surrogate end points of performing laparoscopic abdomino-perineal resection (APR for large rectal cancers. Materials And Methods: Data of 59 patients undergoing laparoscopic APR (LAPR for anorectal malignancies were reviewed retrospectively. Outcomes were evaluated considering the surgical procedure, surface area of the tumor and short-term outcomes. Results: Of the 59 cases, LAPR could be completed in 53 (89.8% patients. Thirty-one (58.4% patients had Astler-Coller C2 stage disease. The mean surface area of the tumors was 24±17.5 (4-83 cm2. The number of median lymph nodes harvested per case was 12 (1-48. Circumferential resection margin (CRM was positive in 11 (20.7% patients. No mortality was reported. Conclusion: This appears to be the first report analyzing the impact of the size of the rectal tumor in LAPR. The data clearly indicates that LAPR is not hampered by the size of the tumor. There appears to be a need for preoperative radiotherapy and chemotherapy before undertaking surgery on larger tumors in view of the higher circumferential resection margin positivity.

  11. Primary hepatic angiosarcoma: multi-institutional comprehensive cancer centre review of multiphasic CT and MR imaging in 35 patients

    International Nuclear Information System (INIS)

    To assess the imaging features of primary hepatic angiosarcoma on multiphasic CT and MR. Multi-institutional review identified 35 adults (mean age, 57.1 years; 22M/13F) with pathologically proven hepatic angiosarcoma and pretreatment multiphasic CT (n = 33) and/or MR (n = 7). Multifocal hepatic involvement was seen in all 35 cases, with at least 10 lesions in 74.3 % (26/35). Mean size of the dominant mass was 8.9 ± 4.7 cm (range, 2.6-20 cm). Individual nodules were typically circumscribed. Arterial-phase foci of hypervascular enhancement without washout were seen in 89.7 % (26/29). Heterogeneously expanding foci of enhancement generally followed blood pool in 88.6 % (31/35). Progressive centripetal (n = 16) or diffuse ''flash-fill'' (n = 4) enhancement pattern resembling cavernous haemangiomas predominated in 20 cases, whereas a ''reverse haemangioma'' centrifugal pattern predominated in 11 cases. Rapid interval growth was seen in 24 (96.0 %) of 25 cases with serial imaging. Vascular invasion was not seen in any case. Underlying cirrhotic morphology was seen in 42.3 % (15/35). Primary hepatic angiosarcomas typically manifest as aggressive multifocal tumors containing small heterogeneous hypervascular foci that progressively expand and follow blood pool. The appearance can mimic cavernous haemangiomas, but distinction is generally possible. In the setting of cirrhosis, lack of tumour washout and vascular invasion argue against multifocal hepatocellular carcinoma. (orig.)

  12. Estimation of seismic moments from local magnitudes and coda durations for the Cairo earthquake aftershocks recorded at Kottamyia (KEG) Broadband station

    OpenAIRE

    M. F. Abdelwahed; H. M. Hussein; M. M. Dessokey; E. M. Abdelrahman

    2003-01-01

    The spectral analysis of fifty-five KEG VBB records from the October 12, 1992 Cairo earthquake source region was performed to obtain the seismic moment. We obtained this parameter in turn to develop empirical local magnitude (ML), seismic moment (Mo), coda duration (D) relations for that region. In this study the data consist of Lg-waves on the vertical component seismograms for the recorded earthquakes with ML ranging from 1.7 to 4.7. The derived empirical relation betwee...

  13. Prevalence of common canine digestive problems compared with other health problems in teaching veterinary hospital, Faculty of Veterinary Medicine, Cairo University, Egypt

    OpenAIRE

    Rakha, Gamal M. H.; Abdl-Haleem, Mounir M.; Haithem A. M. Farghali; Hitham Abdel-Saeed

    2015-01-01

    Aim: The present study was conducted to ascertain the prevalence of common digestive problems compared to other health problems among dogs that were admitted to the teaching veterinary hospital, faculty of veterinary medicine, Cairo University, Egypt during 1 year period from January to December 2013. Also, study the effect of age, sex, breeds, and season on the distribution of digestive problems in dogs. Materials and Methods: A total of 3864 dogs included 1488 apparently healthy (included 8...

  14. Cairo’s Contested Garbage: Sustainable Solid Waste Management and the Zabaleen’s Right to the City

    OpenAIRE

    Wael Fahmi; Keith Sutton

    2010-01-01

    Over the decades, the Zabaleen , the traditional waste (garbage) collectors of Cairo, have created what is arguably one of the world’s most efficient and sustainable resource-recovery and waste-recycling systems. Yet the continuation of this intricate relationship between community, environment and livelihood is jeopardized by the official privatization of municipal solid waste (MSW) services through contracts with technology-intensive multinational corporations which threatens the sustaina...

  15. Cancer

    Science.gov (United States)

    ... Blood tests (which look for chemicals such as tumor markers) Bone marrow biopsy (for lymphoma or leukemia) Chest ... the case with skin cancers , as well as cancers of the lung, breast, and colon. If the tumor has spread ...

  16. Cancer

    Science.gov (United States)

    Cancer begins in your cells, which are the building blocks of your body. Normally, your body forms ... be benign or malignant. Benign tumors aren't cancer while malignant ones are. Cells from malignant tumors ...

  17. Outcomes of patients with unresected stage III and stage IV non-small cell lung cancer: A single institution experience

    Directory of Open Access Journals (Sweden)

    Manpreet Singh Tiwana

    2013-01-01

    Full Text Available Introduction: To report on the demographic profile and survival outcomes of North Indian population affected with stage III and stage IV non-small cell lung cancer (NSCLC. Materials and Methods: From November 2008 to January 2012, 138 consecutively diagnosed NSCLC patients were included in this study. The patient, tumor and treatment related factors were analyzed. Median overall survival (OS, Kaplan-Meier survival plots, t-test, Cox proportional hazards models were generated by multivariate analysis [MVA] and analyzed on SPSS software (version 19.0; SPSS, Inc., Chicago, IL. Results: Median OS of stage III patients was 9.26 ± 1.85 months and 2-year survival rate of 13% while stage IV patients had median OS of 5 ± 1.5 months with a 2-year survival rate of 8%. Cox regression modeling for MVA demonstrated higher biologically equivalent dose (BED ( P = 0.01 in stage III while in stage IV non-squamous histology ( P = 0.01, administration of chemotherapy ( P = 0.02, partial responders to chemotherapy ( P = 0.001, higher BED ( P = 0.02, and those with skeletal metastasis alone ( P = 0.17 showed a better OS. Conclusion: Our data showed that a higher BED is associated with favorable outcomes, indicating a role of dose escalated radiation therapy to the primary lesion in both stage III and essentially in stage IV NSCLC. Additionally, optimal use of chemotherapy relates to better survival. The developing, resource restrained nations need to follow an economically feasible multimodality approach.

  18. Types of Cancer Research

    Science.gov (United States)

    An infographic from the National Cancer Institute (NCI) describing the four broad categories of cancer research: basic research, clinical research, population-based research, and translational research.

  19. Risk perception and priority setting for intervention among hepatitis C virus and environmental risks: a cross-sectional survey in the Cairo community

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    Dewedar Sahar

    2010-12-01

    Full Text Available Abstract Background Hepatitis C virus (HCV recently emerged as a major public health hazard in Egypt. However, dramatic healthcare budget constraints limit access to the costly treatment. We assessed risk perception and priority setting for intervention among HCV, unsafe water, and outdoor air pollution in Cairo city. Methods A survey was conducted in the homes of a representative sample of household heads in Cairo city. Risk perception was assessed using the "psychometric paradigm" where health hazards are evaluated according to several attributes and then summarized by principal component analysis. Priority setting was assessed by individual ranking of interventions reducing health hazards by 50% over five years. The Condorcet method was used to aggregate individual rankings of the three interventions (main study or two of three interventions (validation study. Explanatory factors of priority setting were explored in multivariate generalized logistic models. Results HCV was perceived as having the most severe consequences in terms of illness and out-of-pocket costs, while outdoor air pollution was perceived as the most uncontrollable risk. In the main study (n = 2,603, improved water supply received higher priority than both improved outdoor air quality (60.1%, P P Conclusions The Cairo community prefers to further improving water supply as compared to improved outdoor air quality and screening and treatment of chronic hepatitis C.

  20. High-pressure phase transition in Mn2O3: Application for the crystal structure and preferred orientation of the CaIrO3 type

    Science.gov (United States)

    Santillán, Javier; Shim, Sang-Heon; Shen, Guoyin; Prakapenka, Vitali B.

    2006-08-01

    Our X-ray diffraction measurements reveal that Mn2O3 undergoes a phase transition to the CaIrO3 type, which is proposed for the post-perovskite in MgSiO3, at 27-38 GPa and 300 K, bypassing the other phase transitions observed in sesquioxides. Small distortions in the polyhedra after the transition indicate that the Jahn-Teller effect, which is strong at ambient conditions, is suppressed during the transition. The CaIrO3-type phase exhibits strong preferred orientation of the (010) plane perpendicular to the loading axis before annealing whereas preferred orientation of the (100) and (110) planes was observed after annealing. The pre-annealing texture may result from either the deformation under strong differential stresses or the phase transition. The post-annealing texture may be related to either lower differential stresses or thermal annealing. Our result shows that the texture of the CaIrO3 type can be sensitive to phase transition and annealing as well as differential stresses.

  1. Comparative study analyzing survival and safety of bevacizumab/carboplatin/paclitaxel versus carboplatin/docetaxel in initial treatment of metastatic Her-2-negative breast cancer

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    Abdel Kader Y

    2013-06-01

    Full Text Available Yasser Abdel Kader,1 Marc Spielmann,2 Tamer El-Nahas,1 Amr Sakr,1 Hassan Metwally31Department of Clinical Oncology, Cairo University, Cairo, Egypt; 2Department of Medical Oncology, Institute Gustave Rousssy, VuilleJuif, Paris, France; 3Department of Clinical Oncology, Monufia University, Monufia, EgyptPurpose: In view of the previous reports demonstrating the positive outcome of bevacizumab in metastatic breast cancer, we aimed at comparing the role of bevacizumab-based metronomic combination with taxane (paclitaxel versus a different taxane (docetaxel-based regimen in addition to carboplatin as initial treatment for metastatic Her-2-negative breast cancer.Patients and methods: This is a randomized Phase III study comparing the progression-free survival (PFS and safety in Her-2-negative female patients with initial diagnosis of metastatic breast cancer with World Health Organization performance status of 0–II. Forty-one patients were randomized from September 2008 to July 2009 to receive either; (1 bevacizumab 5 mg/kg day 1 and day 15, carboplatin area under the curve (AUC-2 day 1, day 8, and day 15, and paclitaxel 60 mg/m2 day 1, day 8, and day 15 (arm-I; or (2 carboplatin AUC-5 day 1, docetaxel 75 mg/m2 day 1 (arm-II. The Kaplan–Meier method was used for estimating survival; log-rank test for comparing survival curves. The primary end point was PFS, and secondary end points were overall survival (OS and safety.Results: PFS was 10 months in arm I versus 10.2 months in arm II (P = 0.9. The OS rate was similar in both arms: 37.6 months for arm I versus 37.4 months for arm II (P = 0.92. The toxicity revealed higher incidence of hypertension and proteinuria in arm I; however, with higher incidence of grade III–IV neutropenia and neutropenic fever in arm II. No treatment-related mortality was recorded.Conclusion: Bevacizumab/carboplatin/paclitaxel and carboplatin/docetaxel show comparable PFS and OS with different toxicity profiles

  2. Diachronic development of the Lake of Abusir during the third millennium BC, Cairo, Egypt

    Czech Academy of Sciences Publication Activity Database

    Cílek, Václav; Bárta, M.; Lisá, Lenka; Pokorná, Adéla; Juříčková, L.; Brůna, V.; Mahmoud, A. M. A.; Bajer, A.; Novák, J.; Beneš, J.

    2012-01-01

    Roč. 266, July (2012), s. 14-24. ISSN 1040-6182 R&D Projects: GA ČR GA206/09/1564 Institutional research plan: CEZ:AV0Z30130516 Keywords : Old Kingdom * Abusir and Saqqara, * climatic changes * sedimentology * land use * environmental reconstruction * micromorphology Subject RIV: AC - Archeology, Anthropology, Ethnology Impact factor: 1.962, year: 2012

  3. Role of cyclins A and E in endometrial carcinogenesis in breast cancer patients under tamoxifen treatment Role of cyclins A and E in endometrial carcinogenesis in breast cancer patients under tamoxifen treatment

    International Nuclear Information System (INIS)

    Purpose: The objective of our study was to determine the relevance of cyclins A and E over expression in endometrial carcinogenesis in hormone receptor-positive breast cancer patients under tamoxifen therapy. Experimental design: We assessed expression of cyclins A and E in Endometrial cytology samples collected from 36 ER and PR positive breast cancer patients; under tamoxifen treatment by using the Tao-brush non-invasive brushing cytology technique. Cyclins were detected in the collected samples by means of immuno-cytochemistry. The patients included in this study are a cohort of 36 breast cancer patients who were operated upon at the National Cancer Institute - Cairo University in the period from February 2006 to May 2008 and .received tamoxifen (TAM) as part of their adjuvant treatment. Results; Cyclins A and E were expressed in 17 and 15 of the 36 collected endometrial cytology samples (47.2% and 41.6% respectively). Expression of cyclins A and E was highly correlated to Tamoxifen exposure duration (32 and 43 months respectively) p < 0.001. Tamoxifen median exposure duration was shortened to 21 months in cases showing positivity for either markers, while in cases showing positivity for both cyclins, the median exposure duration was longer (44.5 months) (p < 0.001). Neither cyclin A nor E was detected before median tamoxifen exposure duration of 11 months. Endometrial carcinoma cases had the longest Tamoxifen exposure duration (60 months). Conclusion: Cyclins A and E expression is involved in the carcinogenesis of endometrium in women with breast cancer and under tamoxifen-treatment. Follow up of the patients using these 2 markers is highly recommended starting from the 12th month

  4. Radiotherapy with or without chemotherapy in the treatment of anal cancer. 20-year experience from a single institute

    Energy Technology Data Exchange (ETDEWEB)

    Fakhrian, K.; Sauer, T.; Klemm, S.; Bayer, C.; Haller, B.; Molls, M.; Geinitz, H. [Technische Univ. Muenchen (Germany). Klinikum rechts der Isar

    2013-01-15

    Purpose: To report the efficacy and toxicity of radio(chemo)therapy (RCT) in the management of squamous cell anal carcinoma (SQ-AC) and to evaluate the prognostic factors influencing the outcomes. Patients and methods: A consecutive cohort of 138 patients with cT1-4, cN0-3, cM0 SQ-AC were treated with RCT between 1988 and 2011 at our department. Median follow-up time for surviving patients from the start of RCT was 98 months (range, 1-236 months). Patients were treated with a median radiation dose of 56 Gy (range, 4-61 Gy). Concurrent chemotherapy was administered to 119 patients (86%). Results: The survival rates at 2, 5, and 10 years were 88 {+-} 3, 82 {+-} 4, and 59 {+-} 6%, respectively, with a median overall survival (OS) of 167 months. The cumulative incidence for local recurrence at 2 and 5 years was 8 {+-} 2 and 11 {+-} 3%, respectively. The median disease-free survival (DFS) and colostomy-free survival (CFS) times were 132 and 135 months, respectively. In 19 patients (14%), a distant metastasis was diagnosed after a median time of 19 months. In the multivariate analysis, UICC (International Union Against Cancer) stage I-II, female gender, Eastern Cooperative Oncology Group (ECOG) performance status of 0-1, and good/moderate histologic differentiation (G1-2) were significantly associated with a better OS, DFS, and CFS. Conformal radiotherapy planning techniques were significantly associated with a lower cumulative incidence of local recurrence (11 {+-} 3% vs. 38 {+-} 19% at 5 years, p = 0.006). A higher radiation dose beyond 54 Gy was not associated with an improvement in outcome, neither for smaller - (T1/T2) nor for larger tumors (T3/T4). Conclusion: RCT leads to excellent outcomes - especially in patients with stage I/II and G1/G2 tumors - with acceptable toxicity. The probable advantages of high-dose radiotherapy should be considered carefully against the risk of a higher rate of toxicity. Future studies are needed to investigate the role of a more

  5. A single-institution experience with bevacizumab in the treatment of metastatic colorectal cancer and in conjunction with liver resection

    Science.gov (United States)

    Osterlund, Pia; Peltonen, Reetta; Alanko, Tuomo; Bono, Petri; Isoniemi, Helena

    2014-01-01

    Background Bevacizumab is active in the treatment of metastatic colorectal cancer (mCRC). However, efficacy of bevacizumab has predominantly been evaluated on selected patients with relatively good performance status and minor comorbidities. We evaluated the efficacy and safety of bevacizumab in unselected patients with mCRC, some of whom underwent liver resection. Material and methods All patients with inoperable mCRC, fit for combination chemotherapy (n=180), who were initially not resectable, not included into studies and without contraindications to bevacizumab, and initiated on bevacizumab at the Helsinki University Central Hospital between April 2004 and December 2005 were included (n=114). Most (n=70) received 5-fluorouracil/leucovorin/irinotecan plus bevacizumab as first-line therapy. The remainder (n=44) of the patients received bevacizumab in combination with oxaliplatin or irinotecan with or without 5-fluorouracil or capecitabine. Minimum follow-up was 7 years. Treatment response was evaluated every 8–10 weeks according to RECIST criteria. Results Median age was 59.6 years (range 35–79); male/female ratio was 54%/46%; World Health Organization performance status 0/1/2–3 was 33%/55%/11%, respectively; and the number of metastatic sites, one/two/three or more, was 31%/21%/48%, respectively. Median duration of bevacizumab therapy was 7.8 months (range 0.5–70.5 with pauses). In first-line (n=40), response rate (RR) was 62%, progression-free survival (PFS) 11.7 months, and overall survival (OS) 22.1 months. In second-line (n=43), RR was 44%, PFS 8.7 months, and OS 18.7 months. In later lines (n=31), RR was 14%, PFS 6.7 months, and OS 14.2 months. Ten patients with initially unresectable liver metastases became operable and R0 resection was achieved in 90% (9/10 resections). In 23% (7/31) of operated metastases, no vital tumor cells were found in histologic examination. Operative morbidity was low: two mild infections, no increased bleeding tendency

  6. Community Respiratory Viruses as a Cause of Lower Respiratory Tract Infections Following Suppressive Chemotherapy in Cancer Patients

    International Nuclear Information System (INIS)

    Community respiratory viruses are an important cause of respiratory disease in the immunocompromised patients with cancer. To evaluate the occurrence and clinical significance of respiratory virus infections in hospitalized cancer patients at National Cancer Institute, Cairo University, during anticancer treatment, we studied cases that developed episodes of lower respiratory tract infections (LRTI). Patients and Methods: Thirty patients with LRTI were studied clinically, radiologically, and microbiologically. Sputum cultures were done and an immunofluorescence search for IgM antibodies of influenza A and B, parainfluenza serotypes 1,2 and 3, adenovirus, respiratory syncytial virus, Legionella pneumophila, Coxiella burnettii, Chlamydia pneumoniae, and Mycoplasma pneumoniae were performed on serum samples of patients. The main presenting symptom was cough and expectoration. Hematologic malignancy was the underlying disease in 86.6% of cases. Blood cultures were positive in II patients (36.6%) only. Sputum cultures revealed a bacterial pathogen in [3 cases and fungi in 3; whereas viral and atypical bacterial lgM antibodies were detected in 13 and 4 patients; respectively. Influenza virus was the commonest virus detected, being of type B in 4 cases, type A in one case and mixed A and B in another 5 cases; followed by RSV in 5 patients. Taken together, bacteria were identified as a single cause of LRTI in 10 cases, viruses in 6, fungi in 3 and mixed causes in 7. Still, there were 4 undiagnosed cases. This study showed that respiratory viruses are common in LRTI, either as a single cause or mixed with bacterial pathogens. in hospitalized cancer patients receiving chemotherapy. Diagnostic tests for respiratory viruses should be incorporated in the routine diagnostic study of patients with hematologic malignancies. Also, it must be emphasized that early CT chest is crucial as a base-line prior to initiation of anti-fungal or anti-viral therapy. In cancer patients with a

  7. Accelerated Hyperfractionated Radiotherapy for Cervical Cancer: Multi-Institutional Prospective Study of Forum for Nuclear Cooperation in Asia Among Eight Asian Countries

    International Nuclear Information System (INIS)

    Purpose: To evaluate the toxicity and efficacy of accelerated hyperfractionated radiotherapy (RT) for locally advanced cervical cancer. Methods and Materials: A multi-institutional prospective single-arm study was conducted among eight Asian countries. Between 1999 and 2002, 120 patients (64 with Stage IIB and 56 with Stage IIIB) with squamous cell carcinoma of the cervix were treated with accelerated hyperfractionated RT. External beam RT consisted of 30 Gy to the whole pelvis, 1.5 Gy/fraction twice daily, followed by 20 Gy of pelvic RT with central shielding at a dose of 2-Gy fractions daily. A small bowel displacement device was used with the patient in the prone position. In addition to central shielding RT, intracavitary brachytherapy was started. Acute and late morbidities were graded according to the Radiation Therapy Oncology Group and Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria. Results: The median overall treatment time was 35 days. The median follow-up time for surviving patients was 4.7 years. The 5-year pelvic control and overall survival rate for all patients was 84% and 70%, respectively. The 5-year pelvic control and overall survival rate was 78% and 69% for tumors ≥6 cm in diameter, respectively. No treatment-related death occurred. Grade 3-4 late toxicities of the small intestine, large intestine, and bladder were observed in 1, 1, and 2 patients, respectively. The 5-year actuarial rate of Grade 3-4 late toxicity at any site was 5%. Conclusion: The results of our study have shown that accelerated hyperfractionated RT achieved sufficient pelvic control and survival without increasing severe toxicity. This treatment could be feasible in those Asian countries where chemoradiotherapy is not available

  8. Comorbidity and Karnofksy performance score are independent prognostic factors in stage III non-small-cell lung cancer: an institutional analysis of patients treated on four RTOG studies

    International Nuclear Information System (INIS)

    Purpose: To determine the prognostic role of comorbidity in Stage III non-small cell lung cancer (NSCLC) treated definitively with radiotherapy alone. Methods and Materials: A total of 112 patients with clinical Stage III NSCLC (American Joint Commission on Cancer 1997) enrolled in four Radiation Therapy Oncology Group studies (83-11, 84-03, 84-07, and 88-08 nonchemotherapy arms) at a single institution were analyzed retrospectively for overall survival (OS) and comorbidity. Of the 112 patients, 105 (94%) completed their assigned radiotherapy. The median assigned dose was 50.4 Gy to the lymphatics (range 45-50.4 Gy) and 70.2 Gy to the primary tumor (range 60-79.2 Gy). Comorbidity was rated retrospectively using the Cumulative Illness Rating Scale for Geriatrics (CIRS-G) and Charlson scales. Karnofsky performance scores (KPSs) and weight loss were prospectively recorded. Because only 8 patients had a KPS of 70). Results: The median survival was 10.39 months (range 7.87-12.91). The 2-, 3-, and 5-year OS rate was 20.5%, 12.5%, and 7.1%, respectively. On univariate analysis, clinical stage (IIIA vs. IIIB) was found to be a statistically significant factor influencing OS (p=0.026), and the histologic features, grade, tumor size as measured on CT scans, age, tobacco use, weight loss ≥5%, and total dose delivered to the primary tumor were not. A KPS of ≤70 (p=0.001), the presence of a CIRS-G score of 4 (extremely severe; p=0.0002), and a severity index of >2 (p2 were independently associated with inferior OS; clinical tumor stage was not found to be an independent prognostic factor. Conclusion: KPS and comorbidity are important independent prognostic factors in Stage III NSCLC. Comorbidity should be included in protocols studying advanced stage NSCLC and used for stratification

  9. A randomized phase III trial comparing concomitant chemoradiotherapy versus radiotherapy alone in advanced head and neck cancers - mature results: Yoodhvir Singh Nagar, Lucknow Cancer Institute, India

    International Nuclear Information System (INIS)

    To evaluate contribution of concomitant chemoradiotherapy (CTRT) over and above radiotherapy alone (RT) in previously untreated stage III/IV, squamous cell carcinoma of the head and neck (SCCH and N). Patients with cancers of oral cavity (OC), oropharynx (OP), supraglottis (SG) and hypopharynx (HP) were randomized into RT arm or CTRT arm. Radiotherapy was identical in both arms (70Gy/35 fractions/7 weeks). In CTRT arm concomitant cisplatin (35mg/m2) was given weekly for seven cycles. Surgery was reserved for salvage purposes when required. From May 1996 to December 1998, 155 patients (RT=78, CTRT=77) were enrolled and 139 patients (RT1,CTRT=68) were assessable. Over 90% patients in both arms completed planned treatment. The complete response rate was 51% in RT arm and 71% in CTRT arm (p=0.017). The median disease free survival (DFS) and overall survival (OS) in RT arm and CTRT arm were 3 months vs. 11 months (p=0.0009) and 9 months vs. 26 months (p=0.01) respectively. The 5-year DFS and OS in the two arms were 10% vs. 27% (p=0.000) and 16% vs. 29% (p=0.01) respectively. Acute grade III toxicity was comparable in both the arms (12% vs. 16%, p=0.74). Late grade I/II toxicity was higher in CTRT arm (70% vs. 51%, p=0.09). Serious late toxicities were not seen in both arms. On univariate analysis the favorable factors for immediate response were protocol (CTRT better), primary site (SG and OP better than OC and HP), T-stage (T1-T2 better), Nodes (N0 better than N+), Stage (III > IV), KPS (>80) and lesser overall treatment time (OTT). Multivariate analysis retained protocol, T stage, N stage and OTT as factors independently affecting the immediate response. Addition of concomitant weekly cisplatin (35mg/m2) to radiotherapy improves the likelihood of local control, DFS and OS with acceptable acute and late toxicities and can be recommended as a standard form of treatment in advanced SCCH and N

  10. Structural evolution and Cenozoic tectonostratigraphy of the Cairo-Suez district, north Eastern Desert of Egypt: Field-structural data from Gebel Qattamiya-Gebel Um Reheiat area

    Science.gov (United States)

    Hagag, Wael

    2016-06-01

    Detailed field mapping reveals that continental rifting is strongly deforming the Gebel Qattamiya-Gebel Um Reheiat area and the entire Cairo-Suez district, in north Eastern Desert of Egypt. Rift-related structures are predominantly represented by E to WNW, NNW and NW oriented faults. The E to WNW oriented faults are small and build up the Gebel Qattamiya en echelon fault belt, whereas the faults trending NNW and NW establish a pervasive horst and graben structural style involving some rhomb-shape horsts as Gebel Qattamiya (GQRH), Gebel Um Reheiat (GURRH) and south Gebel Um Reheiat (SGURRH). Rock units of the Eocene succession and Oligocene sediments are well exposed and highly controlled by rift-related structures. Rifting was developed through two rift-phases; initial and major ones. The initial phase (a newly recognized phase in this contribution) has been occurred in Late Eocene (Priabonian), while the main phase was prevailing during Late Oligocene-Early Miocene time and is characterized by hydrothermal veins and basaltic eruptions. Continental transtension in the Cairo-Suez district, including the study area, was probably synchronous with a major tectonic stage (Pyrenean-Atlasic movement) of continental collision between African-Arabian and Eurasian plates in Late Eocene-Oligocene time. Field investigation suggests that the transfer of displacement (slip) from the Gulf of Suez proto-rift into the E-W oriented faults ''relays'' is an important mechanism, which helps to explain the current structural framework and tectonic evolution of the Cairo-Suez district. Reactivation of such faults with right-lateral divergent wrenching with NE-SW oriented extension deformed the Cairo-Suez district with several E-W oriented en echelon fault belts (e.g. Gebel Qattamiya fault belt in the study area). Thus the Cairo-Suez district represents an accommodation or transfer zone in northeastern Egypt, intercepting the ''far-field stresses'' from the Arabian-Nubian Shield, the Red

  11. Mineral physics of the perovskite to post-perovskite transition in CaIrO3 - seismological implications for the lower mantle

    Science.gov (United States)

    Tronnes, R. G.; Stolen, S.; Boffa-Ballaran, T.; Frost, D. J.; Balic-Zunic, T.; Olsen, L. A.

    2007-12-01

    In the system CaIrO3 the perovskite (pv, Pbnm) to post-perovskite (ppv, Cmcm) phase transition is accessible at 1-5 GPa and 1450-1610 C. Both of the CaIrO3-phases are quenchable to ambient conditions, making the system suitable for studies of crystallographic, crystal chemical and mineral physical properties that may provide important guidelines to the behaviour of MgSiO3-based compositions of the lower mantle. Combined results from experimental phase relations, experimental pV-EoS [1], thermal expansivity and density functional theory (DFT) modeling [2] provide insights into the seismologic and geodynamic features of the pv-ppv-transition in the lowermost mantle. Experimental phase relations in the 1-5 GPa range and DFT modeling give Clapeyron slopes for the pv-ppv-transition of 24.5 and 19 MPa/K, respectively, which is about twice the published dp/dT-slopes of the MgSiO3-system. The compressibility of the CaIrO3-crystal structures derived from pv-EoS experiments and DFT-modelling are very similar. In ppv the b-axis compressibility is about twice that of the other two axes. In pv the a- and c-axis compressibilities exceed that of the b-axis by factors of 3 and 2, respectively. The bulk modulus change of the pv to ppv transition is negative, whereas the DFT-derived shear moduli of the two phases give a positive delta-G of the same transition. These results are consistent with DFT-modelling of the MgSiO3-system and with seismological data [3,4]. The apparent suitability of the CaIrO3-component as a low-pressure analogue for the lower mantle MgSiO3-component in terms of crystallographic and mineral physics properties has encouraged an investigation of the incorporation of trivalent cations. By studying the incorporation of a small selection of ions with variable radii in CaIrO3-based pv and ppv, we are searching for systematic relations between various trivalent cation proportions, substitution mechanisms and elasticity parameters. [1] T Boffa-Ballaran, RG Tronnes, D

  12. Establishing daily quality control (QC) in screen-film mammography using leeds tor (max) phantom at the breast imaging unit of USTH-Benavides Cancer Institute

    Science.gov (United States)

    Acaba, K. J. C.; Cinco, L. D.; Melchor, J. N.

    2016-03-01

    Daily QC tests performed on screen film mammography (SFM) equipment are essential to ensure that both SFM unit and film processor are working in a consistent manner. The Breast Imaging Unit of USTH-Benavides Cancer Institute has been conducting QC following the test protocols in the IAEA Human Health Series No.2 manual. However, the availability of Leeds breast phantom (CRP E13039) in the facility made the task easier. Instead of carrying out separate tests on AEC constancy and light sensitometry, only one exposure of the phantom is done to accomplish the two tests. It was observed that measurements made on mAs output and optical densities (ODs) using the Leeds TOR (MAX) phantom are comparable with that obtained from the usual conduct of tests, taking into account the attenuation characteristic of the phantom. Image quality parameters such as low contrast and high contrast details were also evaluated from the phantom image. The authors recognize the usefulness of the phantom in determining technical factors that will help improve detection of smallest pathological details on breast images. The phantom is also convenient for daily QC monitoring and economical since less number of films is expended.

  13. Long-term outcomes for children with acute lymphoblastic leukemia (ALL) treated on The Cancer Institute of New Jersey ALL trial (CINJALL).

    Science.gov (United States)

    Drachtman, Richard A; Masterson, Margaret; Shenkerman, Angela; Vijayanathan, Veena; Cole, Peter D

    2016-10-01

    The Cancer Institute of New Jersey Acute Lymphoblastic Leukemia trial (CINJALL) employed a post-induction regimen centered on intensive oral antimetabolite therapy, with no intravenous methotrexate (MTX). Fifty-eight patients enrolled between 2001 and 2005. A high rate of induction death (n = 3) or induction failure (n = 1) was observed. Among those who entered remission, five-year DFS is 80 ± 8.9% for those at standard risk of relapse and 76 ± 7.8% for high-risk patients, with median follow up over six years. The estimated cumulative incidence of testicular relapse among boys was elevated (13 ± 7.2%) compared to the rate observed on contemporary protocols. We conclude that post-induction therapy using intensive oral antimetabolites for children with acute lymphoblastic leukemia (ALL) can result in overall long-term DFS comparable to that observed among children treated with regimens including intravenous MTX. However, an increased risk of late extramedullary relapse among boys was observed, supporting the prevailing opinion that high-dose MTX improves outcome for children with ALL. PMID:26879921

  14. Radiotherapy alone in breast cancer. I. Analysis of tumor parameters, tumor dose and local control: the experience of the Gustave-Roussy Institute and the Princess Margaret Hospital

    International Nuclear Information System (INIS)

    This retrospective study involved 463 breast cancer patients treated by radiotherapy alone at the Princess Margaret Hospital and at the Institut Gustave-Roussy. These patients either had operable tumors, but were unfit for general anesthesia, or had inoperable tumors due to local contraindications to surgery. Results were analyzed according to tumor response, local recurrence rate, tumor size, tumor fixation, nodal fixation and tumor dose. Conventional statistical analysis of local control showed two significant factors: tumor dose and tumor size. Multivariate analysis permitted to define an ''individual risk'' (IR) of local recurrence according to three independent factors: tumor size, tumor fixation, and nodal fixation. It was shown that the IR was a good prognostic factor for local control. Increase in tumor dose gave a similar effect in the local recurrence relative risk for all the IR groups. According to the slope of the dose-effect curve, it was deduced that a dose increase of 15 Gy can decrease the relative risk of local recurrence 2-fold. In fact, it was shown that tumor dose was the most significant independent factor on local control, able to produce up to a 10-fold increase compared to 2-fold decrease for tumor size. If the IR of local recurrence is known, a theoretical predictive value on local control, taking into account the tumor dose, can be determined according to the present data

  15. The frequency and management of asparaginase-related thrombosis in paediatric and adult patients with acute lymphoblastic leukaemia treated on Dana-Farber Cancer Institute consortium protocols.

    Science.gov (United States)

    Grace, Rachael F; Dahlberg, Suzanne E; Neuberg, Donna; Sallan, Stephen E; Connors, Jean M; Neufeld, Ellis J; Deangelo, Daniel J; Silverman, Lewis B

    2011-02-01

    The optimal management of asparaginase-associated thrombotic complications is not well-defined. We report the features, management and outcome of paediatric (ages 0-18years) and adult (18-50years) patients with acute lymphoblastic leukaemia (ALL) with asparaginase-related venous thromboembolic events (VTE) treated at Dana-Farber Cancer Institute on clinical trials for newly diagnosed ALL between 1991-2008. Of 548 patients, 43 (8%) had VTE, including 27/501 (5%) paediatric and 16/47 (34%) adult patients. Sinus venous thrombosis occurred in 1·6% of patients. Age was the only significant predictor of VTE, with those aged >30years at very high risk (VTE rate 42%). 74% of patients received low molecular weight heparin after VTE. Complications of anticoagulation included epistaxis (9%), bruising (2%) and, in two adult patients, major bleeding. Thirty patients (70%) ultimately received at least 85% of the intended doses of asparaginase. 33% of patients experienced recurrent VTE (paediatric 17% vs. adults 47%, P=0·07). The 48-month event-free survival for patients with VTE was 85±6% compared with 88±2% for those without VTE (P=0·36). This study confirms that, after VTE, asparaginase can be restarted with closely monitored anticoagulation after imaging demonstrates clot stabilization or improvement. With this management strategy, a history of VTE does not appear to adversely impact prognosis. PMID:21210774

  16. Surgical Excision with Forehead Flap as Single Modality Treatment for Basal Cell Cancer of Central Face: Single Institutional Experience of 50 Cases

    Directory of Open Access Journals (Sweden)

    Jagdeep Rao

    2014-01-01

    Full Text Available Basal cell carcinoma (BCC is the most common skin cancer worldwide. The WHO has defined it as “a locally invasive, slowly spreading tumor which rarely metastasizes, arising in the epidermis or hair follicles and in which the peripheral cells usually simulate the basal cells of the epidermis.” Here we discuss the management of BCCs of central face with surgical excision and reconstruction with forehead flap as single modality treatment. Material and Methods. This is a retrospective review of 50 patients who underwent surgical excision of BCC involving the facial region followed by primary reconstruction using forehead flaps at a single institution. There were 20 males and 30 females, mean age of 59 years. Results. No recurrence at primary site was observed during the follow-up of 1–4 yrs. There was no ectropion or exposure sequela. However, epiphora was evident. Size of lesions ranged from 2 to 6 cm. Keloid formation was seen in 2 (4% patients. Functional and cosmetic outcomes were satisfactory. Conclusion. For the face, the best reconstructive effort eventually fails in the face of tumor recurrence. The forehead flap represents one of the best methods for repair of extensive facial defects. Complete tumor extirpation, the primary event, is the key.

  17. Definitive radiotherapy for uterine cervix cancer: long term results for patients treated in the period from 1998 till 2002 at the Institute of Oncology Ljubljana

    International Nuclear Information System (INIS)

    The aim of this retrospective study was to analyse results of the two-dimensional (2D) uterine cervix cancer treatment at the Institute of Oncology Ljubljana from 1998 till 2002, before the three-dimensional (3D) approach was introduced in our clinical practice. Ninety-eight patients with the following FIGO stage distribution were analysed: 10% IB, 7% IIA, 37% IIB, 4% IIIA and 42% IIIB. The influence of age, haemoglobin level, histology, grade, stage, lymph node status, cumulative point A dose, and an overall treatment time on the survival and local control (LC) were evaluated. Acute and late side effects were assessed. Five and 8-year overall survival (OS), disease specific survival (DSS) and LC rate were as follows: 47.2% and 43.0%, 54.7% and 53.4%, 74.9% and 72.5%, respectively. Point A dose and histology of the tumour influenced OS, positive lymph nodes DSS and point A dose LC rate. Probability of grade three and four late complications in the first five years was 7.1% for gastrointestinal tract and 3.3% for genitourinary system and vagina. Point A dose was independent predictor of OS and LC rate, lymph node status predicted DSS, while histology of the tumour influenced OS

  18. The use of Am-241 as Equivalence Thickness Measurement for Irradiation Room at National institute for Cancer and Malacca Hospital: A Review

    International Nuclear Information System (INIS)

    Lead equivalent thickness measurement of a shielding material in diagnostic radiology is very important to ensure that requirements for the purpose of radiation protection of patients, employees and the public are met. The Malaysian Ministry of Health (MOH) has established that the irradiation room must have sufficient shielding thickness, for example for general radiography it must be at least equal to 2.0 mm of Pb, for panoramic dental radiography at least equal to 1.5 mm of Pb and for mammography should be a minimum of 1.0 mm of Pb. This paper presents a technique using americium-241 source to test and verify the integrity of the shielding thickness in term of lead equivalent for irradiation room at National Institute for Cancer (IKN) and General Malacca Hospital. Results of measurement of 10 irradiation rooms conducted in 2012 were analyzed for this presentation. Technical comparison of the attenuation of gamma rays from Am-241 source through the walls of the irradiation room and pieces of lead were used to assess the lead equivalent thickness of the walls. Results showed that almost all the irradiation rooms tested meet the requirements of the Ministry of Health and is suitable for the installation of the intended diagnostic X-ray apparatus. Some specific positions such as door knobs and locks, electrical plug sockets were identified with potential to not met the required lead equivalent thickness hence may contribute to higher radiation exposure to workers and the public. (author)

  19. Measurements of the equilibrium factor and radon dose in some houses in Cairo, Egypt using activated charcoal canister

    International Nuclear Information System (INIS)

    Radon concentration was measured in some houses in Cairo, Egypt using activated charcoal canisters. Equilibrium factor and radon annual equivalent dose are measured as well . The measurements were performed in closed and open ventilation rooms. The average radon concentration was found to be 11.55 Bq/m3 and 24.93 Bq/m3 in open rooms and closed rooms, respectively. The deduced values of equilibrium factor were ranging from 0.171 to 0.180 with an average of 0.175 in open rooms and ranging from 0.190 to 0.205 with an average of 0.194 in closed rooms. The average radon annual equivalent dose was found to be o.111 mSv/y and 0.267 mSv/y in open rooms and closed ones, respectively. These values are much lower than the maximum permissible dose of 1.0 mSv/y recommended by ICRP-60-1990.

  20. Brillouin optical fiber distributed sensor for settlement monitoring while tunneling the metro line 3 in Cairo, Egypt

    Science.gov (United States)

    Dewynter, V.; Rougeault, S.; Magne, S.; Ferdinand, P.; Vallon, F.; Avallone, L.; Vacher, E.; De Broissia, M.; Canepa, Ch.; Poulain, A.

    2009-10-01

    Safety while tunneling is one of the main challenges for underground constructions, avoiding confinement losses, which remain an important risk for public works, leading to additional delays and high insurance costs. In such applications, usual surface instrumentations cannot be set up because of high building density in many overcrowded cities. Tunnelling deals with the challenge of requiring ground surface undisturbed. One original concept proposed in the framework of the European Tunconstruct project, consists in very early settlement detection close to the tunnel vault and before any detectable effect on the surface. The adopted solution is to set-up a sensing element inserted into a directional drilling excavated above the foreseen tunnel. The methodology is based on the well known Brillouin Optical Time Domain Reflectometry (B-OTDR) in singlemode optical fibres and a special cable design dedicated to bending measurement. Two cables, based on different industrial manufacturing processes, have been developed taking into account the strain sensitivity required, the flexibility and the robustness for borehole installation, a low power attenuation and storage on a drum. Industrial prototypes have been manufactured and validated with tests in open air where settlement profiles geometry can be accurately controlled. Demonstration on job site took place on The Greater Cairo Metro Line 3 (CML3) at the beginning of 2009.

  1. Quantifying the Driving Forces of Informal Urbanization in the Western Part of the Greater Cairo Metropolitan Region

    Directory of Open Access Journals (Sweden)

    Taher Osman

    2016-06-01

    Full Text Available This paper discusses the driving forces (DFs of informal urbanization (IU in the greater Cairo metropolitan region (GCMR using the Analytic Hierarchy Process (AHP. The IU patterns in the GCMR have been extremely influenced by seven DFs: geographical characteristics, availability of life facilities, economic incentives, land demand and supply, population increase, administrative function, and development plans. This research found that these forces vary significantly in how they influence urban growth in the three study sectors, namely, the middle, north, and south areas in the western part of the GCMR. The forces with the highest influence were economic incentives in the middle sector, population increase in the north sector, and the administrative function in the south sector. Due to the lower availability of buildable land in the middle sector, the land demand and supply force had a lesser influence in this sector compared to in the north and south sectors. The development plans force had medium influence in all sectors. The geographical characteristics force had little influence in both the middle and the north sectors, but higher influence than economic incentives, availability of life facilities, and development plans in the south sector. Because of the spatial variances in life facilities organizations in the GCMR, the life facilities availability force had little effect on IU in the south sector.

  2. [Cancer].

    Science.gov (United States)

    de la Peña-López, Roberto; Remolina-Bonilla, Yuly Andrea

    2016-09-01

    Cancer is a group of diseases which represents a significant public health problem in Mexico and worldwide. In Mexico neoplasms are the second leading cause of death. An increased morbidity and mortality are expected in the next decades. Several preventable risk factors for cancer development have been identified, the most relevant including tobacco use, which accounts for 30% of the cancer cases; and obesity, associated to another 30%. These factors, in turn, are related to sedentarism, alcohol abuse and imbalanced diets. Some agents are well knokn to cause cancer such as ionizing radiation, viruses such as the papilloma virus (HPV) and hepatitis virus (B and C), and more recently environmental pollution exposure and red meat consumption have been pointed out as carcinogens by the International Agency for Research in Cancer (IARC). The scientific evidence currently available is insufficient to consider milk either as a risk factor or protective factor against different types of cancer. PMID:27603890

  3. Unbundling Institutions

    OpenAIRE

    Daron Acemoglu; Simon Johnson

    2003-01-01

    This paper evaluates the importance of property rights institutions', which protect citizens against expropriation by the government and powerful elites, and contracting institutions', which enable private contracts between citizens. We exploit exogenous variation in both types of institutions driven by colonial history, and document strong first-stage relationships between property rights institutions and the determinants of European colonization (settler mortality and population density bef...

  4. Institutional advantage

    NARCIS (Netherlands)

    Martin, Xavier

    2014-01-01

    Is there such a thing as institutional advantage—and what does it mean for the study of corporate competitive advantage? In this article, I develop the concept of institutional competitive advantage, as distinct from plain competitive advantage and from comparative institutional advantage. I first i

  5. Confucius Institute

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ Confucius Institute(simplified Chinese:孔子学院;traditional Chinese:孔子學院;pinyin:kǒngzǐ xuéyuàn)is a non-profit public institute which aims at promoting Chinese language and culture and supporting local Chinese teaching internationally through affiliated Confucius Institutes.

  6. Relationships among Internet health information use, patient behavior and self efficacy in newly diagnosed cancer patients who contact the National Cancer Institute's NCI Atlantic Region Cancer Information Service (CIS).

    Science.gov (United States)

    Fleisher, Linda; Bass, Sarah; Ruzek, Sheryl Burt; McKeown-Conn, Nancy

    2002-01-01

    This NCI funded study examined the relationship between the use of Internet health information by people newly diagnosed with cancer (N=500), with patient task behavior and perceived self efficacy. Study variables were compared among Direct users of Internet health information (people using the Internet themselves), Indirect users of Internet health information (people receiving Internet health information from friends or family members), and Non-users of Internet health information (people not using the Internet or receiving health information from the Internet). The subjects were recruited from persons who called the Atlantic Region of the NCI's Cancer Information Service (CIS), located at Fox Chase Cancer Center in Philadelphia, PA. Follow up phone interviews were done with participants six weeks after initial contact to assess impact of the use of the Internet on perceived patient task behavior and self efficacy. Results show significant relationships between Internet use and all study variables. PMID:12463827

  7. Dietary fiber intake and risk of breast cancer in postmenopausal women: the National Institutes of Health–AARP Diet and Health Study1234

    OpenAIRE

    Park, Yikyung; Brinton, Louise A.; Subar, Amy F; Hollenbeck, Albert; Schatzkin, Arthur

    2009-01-01

    Background: Although dietary fiber has been hypothesized to lower risk of breast cancer by modulating estrogen metabolism, the association between dietary fiber intake and risk of breast cancer by hormone receptor status is unclear.

  8. Prostate cancer screenings

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000846.htm Prostate cancer screenings To use the sharing features on this ... Intern Med . 2011;155(11):762-71. National Cancer Institute. Prostate Cancer Screening -- for health professionals. Revised April 2, ...

  9. A Multi-institutional Clinical Trial of Rectal Dose Reduction via Injected Polyethylene-Glycol Hydrogel During Intensity Modulated Radiation Therapy for Prostate Cancer: Analysis of Dosimetric Outcomes

    International Nuclear Information System (INIS)

    Purpose: To characterize the effect of a prostate-rectum spacer on dose to rectum during external beam radiation therapy for prostate cancer and to assess for factors correlated with rectal dose reduction. Methods and Materials: Fifty-two patients at 4 institutions were enrolled into a prospective pilot clinical trial. Patients underwent baseline scans and then were injected with perirectal spacing hydrogel and rescanned. Intensity modulated radiation therapy plans were created on both scans for comparison. The objectives were to establish rates of creation of ≥7.5 mm of prostate-rectal separation, and decrease in rectal V70 of ≥25%. Multiple regression analysis was performed to evaluate the associations between preinjection and postinjection changes in rectal V70 and changes in plan conformity, rectal volume, bladder volume, bladder V70, planning target volume (PTV), and postinjection midgland separation, gel volume, gel thickness, length of PTV/gel contact, and gel left-to-right symmetry. Results: Hydrogel resulted in ≥7.5-mm prostate-rectal separation in 95.8% of patients; 95.7% had decreased rectal V70 of ≥25%, with a mean reduction of 8.0 Gy. There were no significant differences in preinjection and postinjection prostate, PTV, rectal, and bladder volumes. Plan conformities were significantly different before versus after injection (P=.02); plans with worse conformity indexes after injection compared with before injection (n=13) still had improvements in rectal V70. In multiple regression analysis, greater postinjection reduction in V70 was associated with decreased relative postinjection plan conformity (P=.01). Reductions in V70 did not significantly vary by institution, despite significant interinstitutional variations in plan conformity. There were no significant relationships between reduction in V70 and the other characteristics analyzed. Conclusions: Injection of hydrogel into the prostate-rectal interface resulted in dose reductions to rectum

  10. Critical Appraisal of Nasolabial Flap for Reconstruction of Oral Cavity Defects in Cancer Patients

    International Nuclear Information System (INIS)

    Purpose: Re-evaluation of nasolabial flap in lip and oral cavity reconstruction and role of each of its variants in reconstructing various intermediate size defects was addressed. Patients and Methods: Case-series study was con-ducted in National Cancer Institute, Cairo University over the period from July 2005 - January 2009 which included 23 patients with clinically T-l N0, T-2 N0 invasive squamous cell carcinoma of buccal mucosa and the vermilion border of the lower lip. Immediately after surgical excision, one stage reconstruction of the defect was done using a type of nasolabial flap. All patients were followed and the median follow-up period was 7.5 month. Results: Twelve patients with the lower lip carcinoma and 11 patients with the carcinoma of buccal mucosa underwent surgical excision under frozen section control. 19 fasciocutaneous nasolabial flap and 4 facial artery musculomucosal flaps were used for reconstruction. Minor wound complications occurred in 2 flaps and one patient required secondary suture. Flap viability was reliable and was not affected by performance of a synchronous neck dissection. Functional results were satisfactory, cosmetic results were good in most of the patients and excellent when facial artery musculomucosal flap was used. Conclusion: The nasolabial flap is a reliable and minimally traumatic local flap for one stage reconstruction of medium size defects in the oral cavity. The abundant blood supply allowed its modification in order to cover larger defects or to obtain better cosmetic results. This versatility makes it more widely used thus minimizing the use of local tongue flaps and split thickness grafts for covering these medium size defects in cases of buccal mucosa cancer or affecting the other lip or commissure in cases of lip cancer. It has a high viability rate, low complication rate; it is quick and easy to perform in addition to its satisfactory functional and cosmetic results.

  11. Lessons from the history of tobacco harm reduction: The National Cancer Institute's Smoking and Health Program and the "less hazardous cigarette".

    Science.gov (United States)

    Parascandola, Mark

    2005-10-01

    Scientists and public health practitioners are sharply divided today over the risks and benefits of tobacco harm-reduction strategies. At the same time, a range of novel tobacco products is being marketed with claims of reduced exposure or risk. Current scientific efforts to study tobacco products and harm reduction should be informed by past experience. During the 1960s and 1970s, there was substantial support within government and academia, as well as among voluntary health organizations, for efforts to modify tobacco products to reduce harm. This paper analyzes the former National Cancer Institute (NCI) Smoking and Health Program, which, between 1968 and 1980, pursued the development of "less hazardous" cigarettes as its primary goal. During this period, the program spent over dollar 50 million on contract research, of which 74% went toward biological and chemical analysis of modified cigarettes, 9.6% to epidemiological studies of risk factors, and only 1.4% to studies evaluating smoking cessation or prevention programs. NCI officials predicted during the mid-1970s that new "low-tar" cigarette brands would substantially reduce smoking-related mortality, but by 1978 the research agenda began to change in response to a reorganization of NCI research activities, modification of government antismoking efforts, and an emerging understanding of nicotine addiction that challenged key scientific assumptions. In retrospect, the program suffered from significant weaknesses that severely limited the likelihood that it would generate knowledge beneficial to public health, including a research agenda that failed to include surveillance and behavioral research, tobacco industry influence of the research agenda, and a lack of access to information about the characteristics of products on the market. There exists today a need for a public health-oriented research agenda on tobacco products and harm reduction, but current efforts should include input from a diverse range of

  12. Continuing professional development for volunteers working in palliative care in a tertiary care cancer institute in India: A cross-sectional observational study of educational needs

    Directory of Open Access Journals (Sweden)

    Jayita Kedar Deodhar

    2015-01-01

    Full Text Available Context: Training programs for volunteers prior to their working in palliative care are well-established in India. However, few studies report on continuing professional development programs for this group. Aims: To conduct a preliminary assessment of educational needs of volunteers working in palliative care for developing a structured formal continuing professional development program for this group. Settings and Design: Cross-sectional observational study conducted in the Department of Palliative Medicine of a tertiary care cancer institute in India. Materials and Methods: Participant volunteers completed a questionnaire, noting previous training, years of experience, and a comprehensive list of topics for inclusion in this program, rated in order of importance according to them. Statistical Analysis Used: Descriptive statistics for overall data and Chi-square tests for categorical variables for group comparisons were applied using Statistical Package for Social Sciences version 18. Results: Fourteen out of 17 volunteers completed the questionnaire, seven having 5-10-years experience in working in palliative care. A need for continuing professional development program was felt by all participants. Communication skills, more for children and elderly specific issues were given highest priority. Spiritual-existential aspects and self-care were rated lower in importance than psychological, physical, and social aspects in palliative care. More experienced volunteers (>5 years of experience felt the need for self-care as a topic in the program than those with less (<5-years experience ( P < 0.05. Conclusions: Understanding palliative care volunteers′ educational needs is essential for developing a structured formal continuing professional development program and should include self-care as a significant component.

  13. Development and implementation of the National Cancer Institute's Food Attitudes and Behaviors Survey to assess correlates of fruit and vegetable intake in adults.

    Directory of Open Access Journals (Sweden)

    Temitope O Erinosho

    Full Text Available Low fruit and vegetable (FV intake is a leading risk factor for chronic disease globally as well as in the United States. Much of the population does not consume the recommended servings of FV daily. This paper describes the development of psychosocial measures of FV intake for inclusion in the U.S. National Cancer Institute's 2007 Food Attitudes and Behaviors Survey.This was a cross-sectional study among 3,397 adults from the United States. Scales included conventional constructs shown to be correlated with fruit and vegetable intake (FVI in prior studies (e.g., self-efficacy, social support, and novel constructs that have been measured in few- to- no studies (e.g., views on vegetarianism, neophobia. FVI was assessed with an eight-item screener. Exploratory factor analysis, Cronbach's alpha, and regression analyses were conducted.Psychosocial scales with Cronbach's alpha ≥0.68 were self-efficacy, social support, perceived barriers and benefits of eating FVs, views on vegetarianism, autonomous and controlled motivation, and preference for FVs. Conventional scales that were associated (p<0.05 with FVI were self-efficacy, social support, and perceived barriers to eating FVs. Novel scales that were associated (p<0.05 with FVI were autonomous motivation, and preference for vegetables. Other single items that were associated (p<0.05 with FVI included knowledge of FV recommendations, FVI "while growing up", and daily water consumption.These findings may inform future behavioral interventions as well as further exploration of other potential factors to promote and support FVI.

  14. Radiotherapeutic management of nasopharyngeal carcinoma. A critical review of 601 cases treated at the Cancer Institute in the period 1947 to 1969

    International Nuclear Information System (INIS)

    The results presented in this paper are based upon information obtained from a critical review of 601 records of nasopharyngeal carcinoma retrieved from the files of the Cancer Institute. The records cover a period of 22 years. An analysis of the age and sex distribution revealed a male excess with a ratio of 2.2:1. No other significant age and sex differences were elucidated. About 80% of all the patients were found to manifest Stage II lesions. Early signs and symptoms were usually mild and non-incapacitating, which the patients usually ignored and may have misled the general practitioners. Single biopsy studies were conducted on 429 patients. The results have shown that more than 95% showed the presence of cell types I, III and IV, (36%, 31%, 31%, respectively), and these were mostly seen in patients manifesting Stage II lesions. Whether the cell type/stage relationship as observed is the true picture could not be ascertained, since the majority of the patients manifested Stage II lesions. The cell type(s) may however be an important factor in the evaluation of biologic response to radiotherapy and may further influence the dose/response relationship. Using port sizes of 6cm x 7cm to 6cm x 8cm, 178 patients were irradiated with doses ranging from about 4000 to 7000 rad (40-70Gy). The results have shown that 74 to 78% of the patients showing a 100% response (complete disappearance of the mass) were irradiated with doses in the range 5000 to 7000 rad (50 to 70Gy). 4000 to 5000 rad (40-50Gy) on the average resulted in optimum response rates to whole-neck irradiation. (author)

  15. Concurrent Hyperfractionated Radiation Therapy and Chemotherapy in Locally Advanced (Stage III) Non-Small-Cell Lung Cancer: Single Institution Experience With 600 Patients

    Energy Technology Data Exchange (ETDEWEB)

    Jeremic, Branislav, E-mail: nebareje@gmail.com [Department of Oncology, University Hospital, Kragujevac (Serbia); Milicic, Biljana; Milisavljevic, Slobodan [Department of Oncology, University Hospital, Kragujevac (Serbia)

    2012-03-01

    Purpose: Our institutional experience with the use of hyperfractionated radiation therapy (RT) alone or concurrently with chemotherapy (RT-CHT) in Stage III non-small-cell lung cancer was reviewed. Methods and Materials: Three phase III and two phase II studies included a total of 600 patients. Hyperfractionated RT alone was given to 127 patients, and hyperfractionated RT-CHT was given to 473 patients. RT doses were 64.8 Gy and 69.6 Gy (using 1.2 Gy twice daily) and 67.6 Gy (using 1.3 Gy twice daily). CHT consisted of concurrent administration of carboplatin and etoposide to 409 patients and concurrent administration of carboplatin and paclitaxel to 64 patients. Results: The median survival times were 19 months, 21 months, and 12 months for all, RT-CHT, and RT-only patients, respectively. The survival difference between the RT-CHT and RT group was significant (p < 0.0001). Four-year rates of local progression-free survival (LPFS) and distant metastasis-free survival (DMFS) were 29% and 35%, respectively, for the entire group. The RT-CHT group had significantly better LPFS rates than the RT group (31% for the RT-CHT group vs. 16% for the RT group; p = 0.0015) but not DMFS rates (36% for the RT-CHT group vs. 36% for the RT group, p = 0.0571). Acute high-grade esophagitis, pneumonitis, and hematological toxicities were seen most frequently and in 11%, 9%, and 12% of patients, respectively. Late high-grade esophageal and bronchopulmonary toxicity were each seen in 6% of patients. Conclusions: Compared to the majority of existing phase II and III studies, this study reconfirmed the excellent results achieved with concurrent RT-CHT, including low toxicity. Concurrent RT-CHT results in survival benefit primarily by increasing LPFS, not DMFS.

  16. Concurrent Hyperfractionated Radiation Therapy and Chemotherapy in Locally Advanced (Stage III) Non-Small-Cell Lung Cancer: Single Institution Experience With 600 Patients

    International Nuclear Information System (INIS)

    Purpose: Our institutional experience with the use of hyperfractionated radiation therapy (RT) alone or concurrently with chemotherapy (RT-CHT) in Stage III non-small-cell lung cancer was reviewed. Methods and Materials: Three phase III and two phase II studies included a total of 600 patients. Hyperfractionated RT alone was given to 127 patients, and hyperfractionated RT-CHT was given to 473 patients. RT doses were 64.8 Gy and 69.6 Gy (using 1.2 Gy twice daily) and 67.6 Gy (using 1.3 Gy twice daily). CHT consisted of concurrent administration of carboplatin and etoposide to 409 patients and concurrent administration of carboplatin and paclitaxel to 64 patients. Results: The median survival times were 19 months, 21 months, and 12 months for all, RT-CHT, and RT-only patients, respectively. The survival difference between the RT-CHT and RT group was significant (p < 0.0001). Four-year rates of local progression-free survival (LPFS) and distant metastasis-free survival (DMFS) were 29% and 35%, respectively, for the entire group. The RT-CHT group had significantly better LPFS rates than the RT group (31% for the RT-CHT group vs. 16% for the RT group; p = 0.0015) but not DMFS rates (36% for the RT-CHT group vs. 36% for the RT group, p = 0.0571). Acute high-grade esophagitis, pneumonitis, and hematological toxicities were seen most frequently and in 11%, 9%, and 12% of patients, respectively. Late high-grade esophageal and bronchopulmonary toxicity were each seen in 6% of patients. Conclusions: Compared to the majority of existing phase II and III studies, this study reconfirmed the excellent results achieved with concurrent RT-CHT, including low toxicity. Concurrent RT-CHT results in survival benefit primarily by increasing LPFS, not DMFS.

  17. How Effective Are Clinical Pathways With and Without Online Peer-Review? An Analysis of Bone Metastases Pathway in a Large, Integrated National Cancer Institute-Designated Comprehensive Cancer Center Network

    Energy Technology Data Exchange (ETDEWEB)

    Beriwal, Sushil, E-mail: beriwals@upmc.edu [Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA (United States); Rajagopalan, Malolan S.; Flickinger, John C.; Rakfal, Susan M. [Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA (United States); Rodgers, Edwin [Via Oncology, Pittsburgh, PA (United States); Heron, Dwight E. [Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA (United States)

    2012-07-15

    Purpose: Clinical pathways are an important tool used to manage the quality in health care by standardizing processes. This study evaluated the impact of the implementation of a peer-reviewed clinical pathway in a large, integrated National Cancer Institute-Designated Comprehensive Cancer Center Network. Methods: In 2003, we implemented a clinical pathway for the management of bone metastases with palliative radiation therapy. In 2009, we required the entry of management decisions into an online tool that records pathway choices. The pathway specified 1 or 5 fractions for symptomatic bone metastases with the option of 10-14 fractions for certain clinical situations. The data were obtained from 13 integrated sites (3 central academic, 10 community locations) from 2003 through 2010. Results: In this study, 7905 sites were treated with 64% of courses delivered in community practice and 36% in academic locations. Academic practices were more likely than community practices to treat with 1-5 fractions (63% vs. 23%; p < 0.0001). The number of delivered fractions decreased gradually from 2003 to 2010 for both academic and community practices (p < 0.0001); however, greater numbers of fractions were selected more often in community practices (p < 0.0001). Using multivariate logistic regression, we found that a significantly greater selection of 1-5 fractions developed after implementation online pathway monitoring (2009) with an odds ratio of 1.2 (confidence interval, 1.1-1.4) for community and 1.3 (confidence interval, 1.1-1.6) for academic practices. The mean number of fractions also decreased after online peer review from 6.3 to 6.0 for academic (p = 0.07) and 9.4 to 9.0 for community practices (p < 0.0001). Conclusion: This is one of the first studies to examine the efficacy of a clinical pathway for radiation oncology in an integrated cancer network. Clinical pathway implementation appears to be effective in changing patterns of care, particularly with online clinical

  18. Crystal structure of post-perovskite-type CaIrO3 reinvestigated: new insights into atomic thermal vibration behaviors

    Directory of Open Access Journals (Sweden)

    Akihiko Nakatsuka

    2015-09-01

    Full Text Available Single crystals of the title compound, the post-perovskite-type CaIrO3 [calcium iridium(IV trioxide], have been grown from a CaCl2 flux at atmospheric pressure. The crystal structure consists of an alternate stacking of IrO6 octahedral layers and CaO8 hendecahedral layers along [010]. Chains formed by edge-sharing of IrO6 octahedra (point-group symmetry 2/m.. run along [100] and are interconnected along [001] by sharing apical O atoms to build up the IrO6 octahedral layers. Chains formed by face-sharing of CaO8 hendecahedra (point-group symmetry m2m run along [100] and are interconnected along [001] by edge-sharing to build up the CaO8 hendecahedral layers. The IrO6 octahedral layers and CaO8 hendecahedral layers are interconnected by sharing edges. The present structure refinement using a high-power X-ray source confirms the atomic positions determined by Hirai et al. (2009 [Z. Kristallogr. 224, 345–350], who had revised our previous report [Sugahara et al. (2008. Am. Mineral. 93, 1148–1152]. However, the displacement ellipsoids of the Ir and Ca atoms based on the present refinement can be approximated as uniaxial ellipsoids elongating along [100], unlike those reported by Hirai et al. (2009. This suggests that the thermal vibrations of the Ir and Ca atoms are mutually suppressed towards the Ir...Ca direction across the shared edge because of the dominant repulsion between the two atoms.

  19. Crystal structure of post-perovskite-type CaIrO3 reinvestigated: new insights into atomic thermal vibration behaviors.

    Science.gov (United States)

    Nakatsuka, Akihiko; Sugiyama, Kazumasa; Yoneda, Akira; Fujiwara, Keiko; Yoshiasa, Akira

    2015-09-01

    Single crystals of the title compound, the post-perovskite-type CaIrO3 [calcium iridium(IV) trioxide], have been grown from a CaCl2 flux at atmospheric pressure. The crystal structure consists of an alternate stacking of IrO6 octa-hedral layers and CaO8 hendeca-hedral layers along [010]. Chains formed by edge-sharing of IrO6 octa-hedra (point-group symmetry 2/m..) run along [100] and are inter-connected along [001] by sharing apical O atoms to build up the IrO6 octa-hedral layers. Chains formed by face-sharing of CaO8 hendeca-hedra (point-group symmetry m2m) run along [100] and are inter-connected along [001] by edge-sharing to build up the CaO8 hendeca-hedral layers. The IrO6 octa-hedral layers and CaO8 hendeca-hedral layers are inter-connected by sharing edges. The present structure refinement using a high-power X-ray source confirms the atomic positions determined by Hirai et al. (2009 ▸) [Z. Kristallogr. 224, 345-350], who had revised our previous report [Sugahara et al. (2008 ▸). Am. Mineral. 93, 1148-1152]. However, the displacement ellipsoids of the Ir and Ca atoms based on the present refinement can be approximated as uniaxial ellipsoids elongating along [100], unlike those reported by Hirai et al. (2009 ▸). This suggests that the thermal vibrations of the Ir and Ca atoms are mutually suppressed towards the Ir⋯Ca direction across the shared edge because of the dominant repulsion between the two atoms. PMID:26396860

  20. Air Pollution Monitoring and Use of Nanotechnology Based Solid State Gas Sensors in Greater Cairo Area, Egypt

    Science.gov (United States)

    Ramadan, A. B. A.

    Air pollution is a serious problem in thickly populated and industrialized areas in Egypt, especially in greater Cairo area. Economic growth and industrialization are proceeding at a rapid pace, accompanied by increasing emissions of air polluting sources. Furthermore, though the variety and quantities of polluting sources have increased dramatically, the development of a suitable method for monitoring the pollution causing sources has not followed at the same pace. Environmental impacts of air pollutants have impact on public health, vegetation, material deterioration etc. To prevent or minimize the damage caused by atmospheric pollution, suitable monitoring systems are urgently needed that can rapidly and reliably detect and quantify polluting sources for monitoring by regulating authorities in order to prevent further deterioration of the current pollution levels. Consequently, it is important that the current real-time air quality monitoring system, controlled by the Egyptian Environmental Affairs Agency (EEAA), should be adapted or extended to aid in alleviating this problem. Nanotechnology has been applied to several industrial and domestic fields, for example, applications for gas monitoring systems, gas leak detectors in factories, fire and toxic gas detectors, ventilation control, breath alcohol detectors, and the like. Here we report an application example of studying air quality monitoring based on nanotechnology `solid state gas sensors'. So as to carry out air pollution monitoring over an extensive area, a combination of ground measurements through inexpensive sensors and wireless GIS will be used for this purpose. This portable device, comprising solid state gas sensors integrated to a Personal Digital Assistant (PDA) linked through Bluetooth communication tools and Global Positioning System (GPS), will allow rapid dissemination of information on pollution levels at multiple sites simultaneously.

  1. Sources of Recharge and Salinity of the Miocene Aquifer Around Cairo City, Inferences from Environmental Isotopes and Hydrochemistry

    International Nuclear Information System (INIS)

    The present investigation has been carried out to explore the recharging sources of the Miocene aquifer around Cairo city and to check its replenishment and the impact of structural and Iithological elements on groundwater flow and quality. The groundwater of the Miocene aquifer Ims so variant hydrochemical characteristics in the eastern and western fringes of south delta. This is compatible with the lithologic nature and sedimentary facies of the aquifer; fluviatile gravely sand (Moghra Formation) to the west and fluviomarine and marine facies to the east. The stable and radioactive isotopes (18 O, D, T and 14 C) collectively indicated that the major bulk of water in the Miocene aquifer is non renewable. The recent recharge from Nile system is not systematic; it is controlled by Iithological and structural elements. The nature of Paleowater recharge is different for the Miocene aquifer in the eastern and western fringes of south delta, it is related in the west to remnants of Paleo Nile water that was recharged during Holocene times and entrapped in the buried old Nile channels. These channels also receive Sub - Recent recharge from Nile water that was flooding in the area prior to completion of Aswan High Dam. The paleo recharge in the eastern fringes is, on the other hand, related to the main pluvial period (around 20000 ybp) of the Nubian Sandstone system. The fluviatile nature of Moghra Formation and the buried channels to the west of south delta accelerated the infiltration and the invasion of last humid phase water (8500 -5000 ybp) causing a freshening of the main pluvial phase recharge

  2. Epidemiological Study Of Risky Behaviours And Their Relation With Mental Ill Health Among Secondary School Students In Cairo

    Directory of Open Access Journals (Sweden)

    Essam A. El-Moselhy; Morsy A. Ammar; Khaled M. Abd-Allah; Ibrahim A.

    2005-06-01

    Full Text Available A cross-sectional design was carried out on 827 students from general and technical secondary schools in Cairo. The aim of this study was to determine the prevalence of risky behaviours among the studied students, to assess their relation with sociodemographic factors and psychological problems and to explore student's attitude toward these behaviours. The data were collected by a standardized interviewing form. Different psychological symptoms were assessed using Middle Sex Hospital Questionnaire. The study showed, 54.1% of the students were having unhealthy diet and tobacco smoking behaviours. Also, all the risky behaviours, except absence of physical exercise practice and suicide attempt, were more common among boys. The most important sociodemographic risk factors were; positive family history of risky behaviours, one parent family and the student's work beside studying (OR=7.11, 4.07 and 3.37, respectively. The most important reasons for unhealthy diet, carrying weapon and engagement in casual sex were imitation (55.2%, to feel grown up (47.1% and peer pressure (39.1%, respectively. While, the most common psychological problem was hysteria (15.1% and the most common neurotic trait was sadness (41.9%. The most important psychological problems risk factors were obsession and hysteria (OR=5.53 and 4.59, respectively. While, the most important neurotic traits risk were irritability and sadness (OR=9.53 and 8.05, respectively. No awareness to the reported risk was present among 96.4% of the students having the risky behaviours (OR=6.41.

  3. Seasonal and spatial variation of atmospheric particulate matter in a developing megacity, the Greater Cairo, Egypt Egipto

    Energy Technology Data Exchange (ETDEWEB)

    Zakey, A.S. [The Abdus Salam International Centre of Theoretical Physics (ICTP) Trieste (Italy)]. E-mail: azakey@ictp.it; Abdel-Wahab, M.M. [Cairo University, Department of Meteorology, Faculty of Science, Cairo (Egypt); Pettersson, J.B.C.; Gatari, M.J.; Hallquist, M. [Department of Chemistry, Atmospheric Science, Goeteborg University, Goeteborg (Sweden)

    2008-04-15

    As an example of a developing megacity the Greater Cairo (GC) area in Egypt has been evaluated with respect to atmospheric particulate matter (PM) and lead (Pb). Particulate matter was collected during 2001-2002 in the two size fractions PM{sub 2}.5 and PM{sub 1}0 at 17 sites representing different activities (industrial, urban, residential and background condition). The PM concentrations were generally high, with yearly average PM{sub 2}.5 and PM{sub 1}0 values of 85 {+-} 12 and 170 {+-} 25 {mu}g/m{sup -}3, respectively. On an annual scale, the high PM levels were due to many sources that included traffic, waste burning and wind blown dust particles emitted from the desert outside GC and the Moqattam hill inside GC. On a seasonal scale, the PM concentrations were highest in the industrial sector during spring, the dusty season, due to the combined effect of dust storm events and anthropogenic emissions over GC. The lowest seasonal concentrations were recorded in the summer season at the background sites. There was a marked increase in PM levels during the period October to December due to burning of waste from harvested rice in the agriculture area in the Nile Delta (north of Cairo). The highest PM{sub 2}.5/PM{sub 1}0 ratio was recorded in the urban sector (0.59) while the lowest ratio was recorded in the residential sector (0.32). The PM{sub 2}.5 and PM{sub 1}0 samples were also analyzed for Pb in order to address the influence of different emission sources. The monthly average concentrations of Pb in both PM{sub 2}.5 (Pb{sub 2}.5) and PM{sub 1}0 (Pb{sub 1}0) varied between 0.4 and 1.8 {+-} {mu}g m{sup -}3 at the non industrial sites. The concentrations were significantly higher in the industrial areas, where concentration up to a maximum of 16 {+-} g m{sup -}3 could be observed. Both the high lead and PM concentrations measured are contributing to local environmental pollution. GC is subjected to high concentrations of particulates most of the year. There is no

  4. Governing the transition to natural gas in Mediteranean Metropolis: The case of Cairo, Istanbul and Sfax (Tunisia)

    International Nuclear Information System (INIS)

    Recent scholarship on urban energy governance has focused on low carbon energy strategies seen as a response to climate change and energy pressure threats. But such approaches tend to overlook the situations of cities from the Global South and emerging countries concerned with strong energy demand growth. The development of urban natural gas networks is an understudied response to such a challenge. Focusing on three cities, Istanbul, Cairo and Sfax (Tunisia), the article analyses the factors and the governance of these energy transitions. It uses a geographical approach to such processes that highlight the mutual influence of the territory in its material and political dimensions and of the policy goals and tools in the implementation. The development of urban gas networks rests upon the proximity of gas deposits. It is determined by metropolitan strategies for economic development as well as by programs aiming to cut energy subsidies. Though urban gas networks have a strong potential for restructuring the physical and social landscapes in cities, the dominant commercial approach taken by energy utilities and morphological constraints in the urban fabric limit their universalization. Natural gas is part of a mix of energies at the urban level and often competes with other energy forms, specifically renewables (like solar water heaters). Lastly, the development of urban natural gas networks sparks heated politics in relation to unfulfilled energy demand and affordability. - Highlights: • Considers the governance of natural gas networks in emerging cities. •Adopts a geographical approach looking at interactions between natural gas infrastructure and urban space. • Switch to natural gas linked to financial purpose (subsidy cuts) more than concern for climate change. • Switch to natural gas shaped by policies governing other urban energy forms. • Urban politics and issues of affordability impact the governance of natural gas transition

  5. Evaluation of daily intake for some elements of radiation protection concern by inhabitants of Greater Cairo Area, Egypt

    Directory of Open Access Journals (Sweden)

    Mohamed H.E. Monged

    2016-07-01

    Full Text Available Concentrations of K, Ca, U, Th, Cs, Sr, I, Al, Cd, Cu, Mn, Pb, Ni, Zn and Cr were determined in common foodstuffs consumed by adult inhabitants of Greater Cairo Area (GCA. Some of these elements have chemical and biological similarity to some of the radionuclides abundantly encountered during nuclear power production and therefore data on these elements could provide important information on their biokinetic behavior. A total of 120 samples were analyzed using Neutron Activation Analysis (NAA and Atomic Absorption Spectrometry (AAS. Highest contributions for the intake of micronutrients (Cu, Mn, Ni and Zn arise from broad bean, rice and wheat flour consumption. Meat, milk, eggs and some vegetables are the major sources of K, Ca, U, Th, Cs, Al, Cd and Pb intake. The medium daily intakes for the adult inhabitants of GCA from the analyzed elements were reported. The lower daily intake of Ca, Th, Cs and I by adult inhabitants of GCA could be due to significantly lower consumption of milk and milk products. The significantly lower intake of calcium by adult inhabitants of GCA may lead to higher uptake of radiostrontium and could result in perhaps higher internal radiation dose. The lower intake values obtained for thorium and uranium, which suggests that radiation dose from their ingestion at natural background levels, is likely to be lower than what may be concluded from International Commission on Radiological Protection (ICRP data. Concerning micronutrients, the recommended values of daily intake of Cu and Mn are conveniently supplied by diet; however, for Cr and Zn they are lower than the recommended daily allowance. Due to high metals concentrations and consumption rates, broad bean is the foodstuff that provided the highest ingestion rates of Cu, Mn, Ni and Zn, being therefore a very important source of micronutrients.

  6. Understanding MgSiO3 Post-Perovskite via NaMgF3 and CaIrO3 Analog Materials

    Science.gov (United States)

    Martin, C.; Parise, J. B.

    2006-12-01

    Knowledge of the structure and properties of MgSiO3 post-perovskite (ppv) is paramount in the study of Earth`s D" layer and core-mantle boundary. However, the extreme pressures and temperatures required to stabilize this phase make in-situ characterization difficult. Rietveld refinement of structure models obtained from x-ray and neutron diffraction data of analog materials including NaMgF3 and CaIrO3, the structure model of MgSiO3 ppv, reveal structural changes accompanying the perovskite (pv)/ppv phase transition. Refined models of NaMgF3 pv just before ppv phase transition indicate some inter-octahedral F-F distances rival the average intra-octahedral distance, which may cause instability in the pv structure and drive the transformation to the ppv phase. The dataset suggests it may be possible to predict the pressure of a ppv phase transition in other pv- (or A2X3-) type materials by extrapolating the cation polyhedra volume ratio with pressure. Diffraction data from CaIrO3 indicate significant disparity between axial compression and thermal expansion schemes (Ka > Kc &αa CaIrO3 at high temperature detail structure changes expected of MgSiO3 ppv considering the thermal gradient above Earth`s core-mantle boundary. In sum, this work assists an increasingly comprehensive understanding of the structure and properties expected of MgSiO3 ppv above the core-mantle boundary.

  7. Assessing the Impact of a Community-Based Health and Nutrition Education on the Management of Diarrhea in an Urban District, Cairo, Egypt

    OpenAIRE

    Abdel-Aziz, Shaimaa B.; Maha A Mowafy; Galal, Yasmine S.

    2015-01-01

    Diarrhea is considered as a major cause of mortality in children aged less than five years old. This pre/post interventional study was designed to assess maternal knowledge about diarrhea and implement a community-based health and nutrition education messages. The study was held in Al-Darb Al-Ahamar (ADAA) district, Cairo, Egypt and targeted a random sample of 600 mothers having at least one child under-five years old and complained of at least one previous attack of diarrhea. The study was c...

  8. Riten der Gewalt: Protest und Aufruhr in Kairo und Damaskus (7./13. bis 10./16. Jahrhundert) (Rites of Violence: Violent Protests in Mamluk Cairo and Damascus)

    OpenAIRE

    Hirschler, Konrad

    2007-01-01

    This article deals with violent forms of ‘popular’ protest and revolt in Cairo and Damascus between the 7th/13th and the 10th/16th centuries. It focuses on the symbolic expressions employed during such periods of violence in order to refine currently employed concepts such as ‘mob-violence’, which tend to describe such events as irrational and spasmodic. The symbolic expressions are analysed with regard to three main themes that played a salient role: the urban spaces that were the theatre of...

  9. Institutional upbringing

    DEFF Research Database (Denmark)

    Gulløv, Eva

    2008-01-01

    agents, empowered with the legitimate right to define and control normality and proper ways of behaving oneself. I aim to show how institutions come to define the normal child and proper childhood in accordance with current efforts toward reinventing national culture, exemplified by legislation requiring......In the chapter, I discuss the role day care institutions play in the construction of the idea of proper childhood in Denmark. Drawing on findings from research on ethnic minority children in two Danish day care institutions, I begin with a discussion of how childcare institutions act as civilising...

  10. Institutional Economics.

    Science.gov (United States)

    Samuels, Warren J.

    1984-01-01

    Institutional economics remains a viable alternative approach to economics. It stresses power, technology, and a holistic and evolutionary approach while critiquing the neoclassical approach. General features of institutional economics are examined, and the work of institutionalists in specific areas is discussed. (RM)

  11. Is Intermediate Radiation Dose Escalation With Concurrent Chemotherapy for Stage III Non–Small-Cell Lung Cancer Beneficial? A Multi-Institutional Propensity Score Matched Analysis

    International Nuclear Information System (INIS)

    Purpose: The clinical benefits and risks of dose escalation (DE) for stage III non–small-cell lung cancer (NSCLC) remain uncertain despite the results from Radiation Therapy Oncology Group (RTOG) protocol 0617. There is significant heterogeneity of practice, with many clinicians prescribing intermediate dose levels between the 0617 study arms of 60 and 74 Gy. This study investigated whether this strategy is associated with any survival benefits/risks by analyzing a large multi-institutional database. Methods and Materials: An individual patient database of stage III NSCLC patients treated with radical intent concurrent chemoradiation therapy was created (13 institutions, n=1274 patients). Patients were divided into 2 groups based on tumor Biological Effective Dose at 10 Gy (BED 10): those receiving standard dose (SD; n=552), consisting of 72Gy ≤ BED 10 ≤ 76.8 Gy (eg 60-64 Gy/30-32 fractions [fr]), and those receiving intermediate dose (ID; n=497), consisting of 76.8Gy < BED 10 < 100.8 Gy (eg >64 Gy/32 fr and <74 Gy/37 fr), with lower-dose patients (n=225) excluded from consideration. Patients were then matched using propensity scores, leading to 2 matched groups of 196 patients. Outcomes were compared using various statistics including interquartile range (IQR), Kaplan-Meier curves, and adjusted Cox regression analysis. Results: Matched groups were found to be balanced except for N stage (more N3 disease in SD), median treatment year (SD in 2003; ID in 2007), platinum and taxane chemotherapy (SD in 28%; ID in 39%), and median follow-up (SD were 89 months; ID were 40 months). Median dose fractionation was 60 Gy/30 fr in SD (BED 10 IQR: 72.0-75.5 Gy) and 66 Gy/33 fr (BED 10 IQR: 78.6-79.2 Gy) in ID. Survival curves for SD and ID matched cohorts were statistically similar (P=.27); however, a nonstatistically significant trend toward better survival for ID was observed after 15 months (median survival SD: 19.3 months; ID: 21.0

  12. Is Intermediate Radiation Dose Escalation With Concurrent Chemotherapy for Stage III Non–Small-Cell Lung Cancer Beneficial? A Multi-Institutional Propensity Score Matched Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, George, E-mail: george.rodrigues@lhsc.on.ca [London Health Sciences Centre, London, Ontario (Canada); Oberije, Cary [MAASTRO Clinic, Maastricht (Netherlands); Senan, Suresh [VU University Medical Center, Amsterdam (Netherlands); Tsujino, Kayoko [Hyogo Cancer Center, Akashi (Japan); Wiersma, Terry [MAASTRO Clinic, Maastricht (Netherlands); Moreno-Jimenez, Marta [Universidad de Navarra, Pamplona (Spain); Kim, Tae Hyun [National Cancer Center, Goyang-si, Gy eonggi (Korea, Republic of); Marks, Lawrence B. [University of North Carolina, Chapel Hill, North Carolina (United States); Rengan, Ramesh [University of Washington, Seattle, Washington (United States); De Petris, Luigi [Karolinska University Hospital, Stockholm (Sweden); Ramella, Sara [Campus Bio-Medico University, Rome (Italy); DeRuyck, Kim [Ghent University, Ghent (Belgium); De Dios, Núria Rodriguez [Universidad Pompeu Fabra, Barcelona (Spain); Warner, Andrew [London Health Sciences Centre, London, Ontario (Canada); Bradley, Jeffrey D. [Washington University School of Medicine, St. Louis, Missouri (United States); Palma, David A. [London Health Sciences Centre, London, Ontario (Canada)

    2015-01-01

    Purpose: The clinical benefits and risks of dose escalation (DE) for stage III non–small-cell lung cancer (NSCLC) remain uncertain despite the results from Radiation Therapy Oncology Group (RTOG) protocol 0617. There is significant heterogeneity of practice, with many clinicians prescribing intermediate dose levels between the 0617 study arms of 60 and 74 Gy. This study investigated whether this strategy is associated with any survival benefits/risks by analyzing a large multi-institutional database. Methods and Materials: An individual patient database of stage III NSCLC patients treated with radical intent concurrent chemoradiation therapy was created (13 institutions, n=1274 patients). Patients were divided into 2 groups based on tumor Biological Effective Dose at 10 Gy (BED 10): those receiving standard dose (SD; n=552), consisting of 72Gy ≤ BED 10 ≤ 76.8 Gy (eg 60-64 Gy/30-32 fractions [fr]), and those receiving intermediate dose (ID; n=497), consisting of 76.8Gy < BED 10 < 100.8 Gy (eg >64 Gy/32 fr and <74 Gy/37 fr), with lower-dose patients (n=225) excluded from consideration. Patients were then matched using propensity scores, leading to 2 matched groups of 196 patients. Outcomes were compared using various statistics including interquartile range (IQR), Kaplan-Meier curves, and adjusted Cox regression analysis. Results: Matched groups were found to be balanced except for N stage (more N3 disease in SD), median treatment year (SD in 2003; ID in 2007), platinum and taxane chemotherapy (SD in 28%; ID in 39%), and median follow-up (SD were 89 months; ID were 40 months). Median dose fractionation was 60 Gy/30 fr in SD (BED 10 IQR: 72.0-75.5 Gy) and 66 Gy/33 fr (BED 10 IQR: 78.6-79.2 Gy) in ID. Survival curves for SD and ID matched cohorts were statistically similar (P=.27); however, a nonstatistically significant trend toward better survival for ID was observed after 15 months (median survival SD: 19.3 months; ID: 21.0

  13. Comparing docetaxel with gemcitabine as second-line chemotherapy in patients with advanced non-small cell lung cancer: A single institute randomized phase II study

    Directory of Open Access Journals (Sweden)

    Khosravi A

    2015-01-01

    Full Text Available Background: Platinum-based doublet chemotherapy is the backbone of treatment in advanced non-small cell lung cancer (NSCLC however second-line treatment options are controversial particularly in patients with borderline performance status (PS of 2. The aim of this study was to compare efficacy and toxicity of weekly docetaxel versus gemcitabine in this clinical setting. Patients and methods: A total of 70 patients with advanced (stage IIIB, IV NSCLC entered this single institute study. Cases of this study had experienced disease progression after the first-line platinum-based doublet chemotherapy, with PS 0- 2 in “Eastern Cooperative Oncology Group” scale. They were randomly assigned by stratified blocks to receive docetaxel 35 mg/m2 (Arm A, n=34 or gemcitabine 1000 mg/m2 (Arm B, n=36 days 1, 8 and 15, every three weeks, for up to six cycles. Primary end point was progression free survival (PFS and secondary end points were objective response rate, disease control rate, median overall survival (OS and toxicity. Dose modification was permitted upon clinician’s discretion for each individual patient. Results: Median of PFS was 2.02 months in arm A and 2.63 months in arm B (HR= 1.279; 95% CI: 0.710-2.304, P= 0.551. Although median OS for arm A was numerically greater (9.2 months than arm B (8.3 months it was statistically non-significant (HR= 1.384; 95% CI: 0.632 to 2.809, P= 0.59. Objective response was higher in Arm B than that in Arm A (P= 0.20 but disease control rates were statistically different in both arms (P= 0.034. Statistically significant differences in term of leukopenia was seen in arm B (P= 0.013. Conclusion: This study, with limited number of cases, indicates that in advanced NSCLC, weekly docetaxel and gemcitabine are reasonable second-line treatment options with statistically similar effectiveness in terms of PFS and median OS with manageable toxicities in patients with PS 0-2.

  14. Carotid blowout syndrome in pharyngeal cancer patients treated by hypofractionated stereotactic re-irradiation using CyberKnife: A multi-institutional matched-cohort analysis

    International Nuclear Information System (INIS)

    Background and purpose: Although reirradiation has attracted attention as a potential therapy for recurrent head and neck tumors with the advent of modern radiotherapy, severe rate toxicity such as carotid blowout syndrome (CBOS) limits its potential. The aim of this study was to identify the risk factors of CBOS after hypofractionated stereotactic radiotherapy (SBRT). Methods and patients: We conducted a matched-pair design examination of pharyngeal cancer patients treated by CyberKnife reirradiation in four institutes. Twelve cases with CBOS were observed per 60 cases without CBOS cases. Prognostic factors for CBOS were analyzed and a risk classification model was constructed. Results: The median prescribed radiation dose was 30 Gy in 5 fractions with CyberKnife SBRT after 60 Gy/30 fractions of previous radiotherapy. The median duration between reirradiation and CBOS onset was 5 months (range, 0–69 months). CBOS cases showed a median survival time of 5.5 months compared to 22.8 months for non-CBOS cases (1-year survival rate, 36% vs.72%; p = 0.003). Univariate analysis identified an angle of carotid invasion of >180°, the presence of ulceration, planning treatment volume, and irradiation to lymph node areas as statistically significant predisposing factors for CBOS. Only patients with carotid invasion of >180° developed CBOS (12/50, 24%), whereas no patient with tumor involvement less than a half semicircle around the carotid artery developed CBOS (0/22, 0%, p = 0.03). Multivariate Cox hazard model analysis revealed that the presence of ulceration and irradiation to lymph nodes were statistically significant predisposing factors. Thus, we constructed a CBOS risk classification system: CBOS index = (summation of risk factors; carotid invasion >180°, presence of ulceration, lymph node area irradiation). This system sufficiently separated the risk groups. Conclusion: The presence of ulceration and lymph node irradiation are risk factors of CBOS. The CBOS index

  15. 78 FR 73552 - National Institute On Alcohol Abuse and Alcoholism; National Institute On Drug Abuse; and...

    Science.gov (United States)

    2013-12-06

    ... HUMAN SERVICES National Institutes of Health National Institute On Alcohol Abuse and Alcoholism; National Institute On Drug Abuse; and National Cancer Institute; Notice of Meeting Pursuant to section 10(a... meeting of the National Advisory Council on Alcohol Abuse and Alcoholism, National Advisory Council...

  16. Electronic spin and valence states of Fe in CaIrO3-type silicate post-perovskite in the Earth's lowermost mantle

    Science.gov (United States)

    Mao, Z.; Lin, J. F.; Jacobs, C.; Watson, H. C.; Xiao, Y.; Chow, P.; Alp, E. E.; Prakapenka, V. B.

    2010-11-01

    The electronic spin and valence states of Fe in post-perovskite ((Mg0.75Fe0.25)SiO3) have been investigated by synchrotron X-ray diffraction, Mössbauer and X-ray emission spectroscopy at 142 GPa and 300 K. Rietveld refinement of the X-ray diffraction patterns revealed that our sample was dominated by CaIrO3-type post-perovskite. Combined Mössbauer and X-ray emission results show that Fe in post-perovskite is predominantly Fe2+ (70%) in the intermediate-spin state with extremely high quadrupole splitting of 3.77(25) mm/s. The remaining 30% Fe can be assigned to two sites. Compared with recent studies, our results indicate that the intermediate-spin Fe2+ is stabilized in CaIrO3-type post-perovskite over a wide range of Fe content, whereas the low-spin Fe3+ is more dominant in the 2 × 1 kinked post-perovskite structure. The characterization of these structural and compositional effects on the spin and valence states of Fe in post-perovskite can help in understanding the geochemical and geophysical behavior of the core-mantle region.

  17. Deformation microtextures in CaIrO3 post-perovskite under high stress conditions using a laser-heated diamond anvil cell

    Science.gov (United States)

    Miyajima, N.; Niwa, K.; Heidelbach, F.; Yagi, T.; Ohgushi, K.

    2010-03-01

    Deformation microstructures of CaIrO3 post perovskite (PPv) in a laser heated diamond anvil cell (DAC) are examined using transmission electron microscopy. Under a high stress and strain rate in the deformation condition, a high density of the {110} twin domains were at first time observed in post perovskite structure, as well as [100] and [001] dislocations on the (010) plane. The exchange of the a-axis for the b-axes in the twin mechanism can reduce a stress in a single crystal at the beginning of the uniaxial compression. The {110} plane in PPv corresponds with that of the crystallographic preferred orientation that was previously reported in deformed MgSiO3 and MgGeO3 PPv in DACs. This result implies that the formation of the twin domains can play an important role in CaIrO3 PPv deformations under high stress and strain rate conditions (e.g., Deformation by DAC).

  18. Observation of electrical and magnetic property of CaIrO3 and CaRhO3 post-perovskite by electrical resistivity measurement under high pressure

    Science.gov (United States)

    Ichimaru, Kota; Ohta, Kenji; Shimizu, Katsuya; Ohgushi, Kenya; Yamaura, Kazunari

    2013-06-01

    Since discovery of MgSiO3 post-perovskite (PPv) phase, high-pressure polymorph of MgSiO3 perovskite (Pv), there are extensive studies regarding physical properties of various PPv materials. It is well known that the crystal structure of high-Tc cuprates is based on Pv structure. Material with PPv structure is thus expected to show superconducting behavior with high Tc. Here we investigated electrical properties of CaIrO3 and CaRhO3 PPv. These PPv materials are quenchable to ambient condition, and known as a quasi-2D Mott Insulator showing antiferromagnetic transition at low temperature. We performed electrical resistivity measurements on the samples under high pressure and low temperature conditions up to 191 GPa, and found that the energy gap of both samples came close to zero with applying pressure. On CaIrO3 PPv, we observed an abrupt increase in sample resistivity at low temperature, which is likely to correspond to antiferromagnetic transition in the sample. The Néel temperature decreased with applying pressure. In the experiments on CaRhO3 PPv, we could not observe such resistivity jump likely caused by the magnetic transition.

  19. Ecological Risk Assessment of Metal Pollution along Greater Cairo Sector of the River Nile, Egypt, Using Nile Tilapia, Oreochromis niloticus, as Bioindicator

    Directory of Open Access Journals (Sweden)

    Wael A. Omar

    2015-01-01

    Full Text Available The present work aims to evaluate seasonal metal pollution along Greater Cairo sector of the River Nile, Egypt, using wild Nile tilapia, Oreochromis niloticus, as bioindicator and to conduct a risk assessment for human consumers. Greater Cairo is the largest populated area along the whole course of River Nile with a wide range of anthropogenic activities. Effects of metal pollution on fish body indices were studied using condition factor (CF and scaled mass index (SMI. Metal pollution index (MPI showed that the total metal load in fish organs followed the follwoing order: kidney > liver > gill > muscle which gives a better idea about the target organs for metal accumulation. Metal concentrations in fish muscle (edible tissue showed the following arrangement: Fe > Zn > Cu > Mn > Pb > Cd. Metal’s bioaccumulation factor (BAF in fish muscle showed the following arrangement: Zn > Cu > Fe > Mn > Cd and Pb. The hazard index (HI as an indicator of human health risks associated with fish consumption showed that adverse health effects are not expected to occur in most cases. However, the metals’ cumulative risk effects gave an alarming sign specifically at high fish consumption rates.

  20. Analysis of Sociodemographic parameters of patients admitted in a newly established palliative care center in a regional cancer institute of north-west India

    Directory of Open Access Journals (Sweden)

    Mukesh Kumar Singhal

    2014-01-01

    Conclusions: Palliative care services are an indispensable part of a tertiary regional cancer care center. The oncologists should be made aware of the requirement of better relief of pain and other distressing symptoms to provide better quality of life to the patients suffering from advanced cancer.

  1. Deformation of the CaIrO3 Post-Perovskite Phase to 5 GPa and 1300 K in the Multi-Anvil Press

    Science.gov (United States)

    Miyagi, L.; Nishiyama, N.; Wang, Y.; Kubo, A.; West, D. V.; Cava, R. J.; Duffy, T. S.; Wenk, H.

    2006-12-01

    At ambient conditions, CaIrO3 is isostructural with MgSiO3 post-perovskite and thus can serve as an analog for studying the plastic properties of the post-perovskite phase. At present the only way to attain the pressures needed for MgSiO3 post-perovskite is in the diamond anvil cell (DAC). However, current technology for radial diffraction experiments does not allow deformation at high-temperatures in the stability field of MgSiO3 post-perovskite and thus investigation of possible high-temperature slip systems that may affect texturing is not possible. The advantage of the multi-anvil press is that it allows for relatively large volume deformation at simultaneous high-temperature and pressure, while also allowing the user to decouple hydrostatic stress from deviatoric stresses. The disadvantage is that the available pressure range is greatly reduced compared to the DAC. The stability field of CaIrO3 post-perovskite extends to 1800 K at 3 GPa, making it amenable to study with the multi-anvil press. Here we study the plastic behavior of CaIrO3 post-perovskite at a variety of conditions within its stability field. Polycrystalline CaIrO3 post-perovskite was synthesized from a 1:1 molar ratio of CaO and IrO2 by first heating in a vacuum-sealed silica tube to 980° C at ambient pressure for 68 hours followed by compression to 7 GPa and 1100° C for 4 hours. The sample was deformed in the D-DIA multi-anvil press at pressures of 2-3 GPa and 4-5 GPa and temperatures of 298 K, 600 K, 800 K, 1000 K, and 1300 K. Deformation was accomplished in several compression cycles of up to 20% strain for each temperature and pressure. Each compression cycle was followed by extension to 0% strain. Quantitative texture information is obtained using in-situ synchrotron x- ray diffraction images and the Rietveld method to deconvolute spectra. In all cases we find that the (010) lattice planes align perpendicular to the compression direction, and that there is no change in texture with

  2. CSCAPES Institute

    Energy Technology Data Exchange (ETDEWEB)

    Alex Pothen

    2008-10-26

    We report on the progress made by researchers of the CSCAPES Institute at Old Dominion University for the years 2007 and 2008 in the areas of research, software creation, education and training, and outreach activities.

  3. Institutional Ethnography

    DEFF Research Database (Denmark)

    Lund, Rebecca; Tienari, Janne

    2016-01-01

    managerial respondents. This leads to another bias in the study of M&As: an managerial one. These critiques are an important step in pinpointing some of the problematic aspects in the field, which we suggest can be part remedied by institutional ethnography developed by Dorothy Smith and her colleagues. In...... institutional ethnography the notion of objectification is applied to describe research processes like those that have been found to dominate in scholarly work on M&As. In this chapter, we offer an outline of Smiths critique of objectification, elucidate how institutional ethnography seeks to address it, and...... point to some of the problems in M&A studies identified through this lens. Finally, we argue why institutional ethnography, in comparison with other methods of inquiry, is particularly fruitful in the study of mergers and acquisitions....

  4. Institutional Investors

    DEFF Research Database (Denmark)

    Birkmose, Hanne Søndergaard; Strand, Therese

    Research Question/Issue: Institutional investors are facing increased pressure and threats of legislation from the European Union to abandon passive ownership strategies. This study investigates the prerequisites for – and potential dissimilarities in the practice of, active ownership among...... institutional investors in two Scandinavian countries with diminutive legal and cultural distance in general. Research Findings/Insights: Using data on shareholder proposals from Danish and Swedish annual general meetings from 2006 throughout 2010, we find that institutional investors are approximately a....... Practitioner/Policy Implications: Regulators should be aware of the impact by local governance mechanisms, and how shareholders react under different legal and practical prerequisites. The paper also highlights legal elements that differ between Denmark and Sweden, and which might affect institutional activism....

  5. Institutional economics

    OpenAIRE

    Rossiaud, Sylvain; Locatelli, Catherine

    2010-01-01

    The discipline of institutional economics has gained increasing prominence in recent years, because standard economic explanations can often not come to grips with major contemporary policy issues, such as economic reform in affluent, but dysfunctional economies, the transformation of the failed socialist command economies and the governance problems of the new industrial economies. Institutional economists point out that rule systems matter greatly to explaining these problems and that insti...

  6. IAEA Laboratory activities. The IAEA Laboratories at Vienna and Seibersdorf, the International Laboratory of Marine Radioactivity at Monaco, the International Centre for Theoretical Physics at Trieste, the Middle Eastern Regional Radioisotope Centre for the Arab Countries, Cairo. Sixth report

    International Nuclear Information System (INIS)

    This sixth 'IAEA Laboratory Activities' report describes development and work during the year 1968. It includes activities of the IAEA Laboratories at Vienna and Seibersdorf, the International Laboratory of Marine Radioactivity at Monaco, the International Centre for Theoretical Physics at Trieste, and the Middle Eastern Regional Radioisotope Centre for the Arab Countries at Cairo. (author)

  7. IAEA Laboratory activities. The IAEA Laboratories at Vienna and Seibersdorf, the International Laboratory of Marine Radioactivity at Monaco, the International Centre for Theoretical Physics at Trieste, the Middle Eastern Regional Radioisotope Centre for the Arab Countries, Cairo. Fourth report

    International Nuclear Information System (INIS)

    This fourth 'IAEA Laboratory Activities' report describes development and work during the year 1966. It includes activities of the IAEA Laboratories at Vienna and Seibersdorf, the International Laboratory of Marine Radioactivity at Monaco, the International Centre for Theoretical Physics at Trieste, and the Middle Eastern Regional Radioisotope Centre for the Arab Countries at Cairo. (author)

  8. IAEA laboratory activities. The IAEA laboratories at Vienna and Seibersdorf, the International Laboratory of Marine Radioactivity at Monaco, the International Centre for Theoretical Physics at Trieste, the Middle Eastern Regional Radioisotope Centre for the Arab Countries, Cairo. 3rd report

    International Nuclear Information System (INIS)

    This third 'IAEA Laboratory Activities' report describes development and work during the year 1965. It includes activities of the IAEA Laboratories at Vienna and Seibersdorf, the International Laboratory of Marine Radioactivity at Monaco, the International Centre for Theoretical Physics at Trieste, and the Middle Eastern Regional Radioisotope Centre for the Arab Countries at Cairo

  9. 75 FR 42758 - National Institutes of Health

    Science.gov (United States)

    2010-07-22

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute; Notice of Meeting Pursuant to... Institutes of Health, 9000 Rockville Pike, Building 31, C Wing, 6th Floor, Conference Room 10, Bethesda,...

  10. Metastatic Cancer

    Science.gov (United States)

    ... of recurrent disease and assessment of prognosis. Clinical Radiology 2007; 62(1):28–34. [PubMed Abstract] Talmadge ... your website or other digital platform? Our syndication services page shows you how. National Cancer Institute at ...

  11. CANCER

    Directory of Open Access Journals (Sweden)

    N. Kavoussi

    1973-09-01

    Full Text Available There are many carcinogenetic elements in industry and it is for this reason that study and research concerning the effect of these materials is carried out on a national and international level. The establishment and growth of cancer are affected by different factors in two main areas:-1 The nature of the human or animal including sex, age, point and method of entry, fat metabolism, place of agglomeration of carcinogenetic material, amount of material absorbed by the body and the immunity of the body.2 The different nature of the carcinogenetic material e.g. physical, chemical quality, degree of solvency in fat and purity of impurity of the element. As the development of cancer is dependent upon so many factors, it is extremely difficult to determine whether a causative element is principle or contributory. Some materials are not carcinogenetic when they are pure but become so when they combine with other elements. All of this creates an industrial health problem in that it is almost impossible to plan an adequate prevention and safety program. The body through its system of immunity protects itself against small amounts of carcinogens but when this amount increases and reaches a certain level the body is not longer able to defend itself. ILO advises an effective protection campaign against cancer based on the Well –equipped laboratories, Well-educated personnel, the establishment of industrial hygiene within factories, the regular control of safety systems, and the implementation of industrial health principles and research programs.

  12. Prostate Cancer: Sextant Localization at MR Imaging and MR Spectroscopic Imaging before Prostatectomy—Results of ACRIN Prospective Multi-institutional Clinicopathologic Study

    OpenAIRE

    Weinreb, Jeffrey C; Blume, Jeffrey D.; Coakley, Fergus V.; Wheeler, Thomas M; Cormack, Jean B.; Sotto, Christopher K.; Cho, Haesun; Kawashima, Akira; Tempany-Afdhal, Clare M.; Macura, Katarzyna J.; Rosen, Mark; Gerst, Scott R.; Kurhanewicz, John

    2009-01-01

    Purpose: To determine the incremental benefit of combined endorectal magnetic resonance (MR) imaging and MR spectroscopic imaging, as compared with endorectal MR imaging alone, for sextant localization of peripheral zone (PZ) prostate cancer.

  13. Strategies for Biochemical and Pathologic Quality Assurance in a Large Multi-Institutional Biorepository; The Experience of the PROCURE Quebec Prostate Cancer Biobank

    OpenAIRE

    Brimo, Fadi; Aprikian, Armen; Latour, Mathieu; Têtu, Bernard; Doueik, Alexandre; Scarlata, Eleonora; Hamel, Lucie; McKercher, Ginette; Saad, Fred; Lacombe, Louis; Carmel, Michel; Chevalier, Simone

    2013-01-01

    Well-characterized, high-quality fresh-frozen prostate tissue is required for prostate cancer research. As part of the PROCURE Prostate Cancer Biobank launched in 2007, four University Hospitals in Quebec joined to bank fresh frozen prostate tissues from radical prostatectomies (RP). As the biobank progressed towards allocation, the nature and quality of the tissues were determined. RP tissues were collected by standardized alternate mirror-image or biopsy-based targeted methods, and frozen f...

  14. Knowledge of risk factors, beliefs and practices of female healthcare professionals towards breast cancer in a tertiary institution in Lagos, Nigeria

    OpenAIRE

    Odusanya Olumuyiwa O; Ibrahim Nasiru A

    2009-01-01

    Abstract Background Breast cancer is the leading female malignancy in Nigeria. Screening for early detection has led to reduction in mortality from the disease. It is known that attitudes of physicians and motivation by community nurses influence uptake of screening methods by women. This study aims to investigate knowledge of breast cancer risk factors, beliefs about treatment and practice of screening methods among a cohort of female healthcare professionals in Lagos, Nigeria. Methods A cro...

  15. Retsmedicinsk Institut

    DEFF Research Database (Denmark)

    Leth, Peter Mygind; Gregersen, Markil Ebbe Gregers

    1996-01-01

    Retsmedicinsk Institut hører under Aarhus Universitet og har pligt til at undervise og forske, men adskiller sig fra andre institutter ved at have en omfattende virksomhed med rekvireret arbejde, idet Statsobducenturet for Nørrejylland er henlagt til instituttet. Professoren, som også er statsobd......Retsmedicinsk Institut hører under Aarhus Universitet og har pligt til at undervise og forske, men adskiller sig fra andre institutter ved at have en omfattende virksomhed med rekvireret arbejde, idet Statsobducenturet for Nørrejylland er henlagt til instituttet. Professoren, som også er...... institut. De bygningsmæssige forhold er utidssvarende og medfører arbejdsmæssige og retssikkerhedsmæssige problemer, En snarlig udflytning er derfor nødvendig....

  16. Colon Cancer

    Science.gov (United States)

    From 2000 until 2010 with the support from the National Cancer Institute, the Mouse Models for Human Cancer Consortium, and the Howard Hughes Medical Institute workshops and conferences to advance the understanding and use of animal models in colorectal cancer research have been organized .

  17. Unimagined Institutions

    DEFF Research Database (Denmark)

    Zangenberg, Mikkel Bruun

    2007-01-01

    In this paper it is argued that war contains inherent and thus necessary aesthetic traits (ranging from sensory data to narrative features), but that existing research institutions throughout the West have failed to address this issue adequately, in terms of research policy, recruitment and...... methodology. Accordingly, it is suggested that scholars from the humanities in particular aggressively seek to develop new types of research institutions and methods in order to deal with the manifold forms of overlap between warfare and aesthetics. In empirical terms, focus is limited to the current...

  18. Strategies for Biochemical and Pathologic Quality Assurance in a Large Multi-Institutional Biorepository; The Experience of the PROCURE Quebec Prostate Cancer Biobank

    Science.gov (United States)

    Aprikian, Armen; Latour, Mathieu; Têtu, Bernard; Doueik, Alexandre; Scarlata, Eleonora; Hamel, Lucie; McKercher, Ginette; Saad, Fred; Lacombe, Louis; Carmel, Michel; Chevalier, Simone

    2013-01-01

    Well-characterized, high-quality fresh-frozen prostate tissue is required for prostate cancer research. As part of the PROCURE Prostate Cancer Biobank launched in 2007, four University Hospitals in Quebec joined to bank fresh frozen prostate tissues from radical prostatectomies (RP). As the biobank progressed towards allocation, the nature and quality of the tissues were determined. RP tissues were collected by standardized alternate mirror-image or biopsy-based targeted methods, and frozen for banking. Clinical/pathological parameters were captured. For quality control, two presumed benign and two presumed cancerous frozen, biobanked tissue blocks per case (10/site) were randomly selected during the five years of collection. In a consensus meeting, 4 pathologists blindly evaluated slides (n=160) and graded quality, Gleason score (GS), and size of cancer foci. The quality of tissue RNA (37/40 cases) was assessed using the RNA Integrity Number. The biobank included 1819 patients of mean age: 62.1 years; serum PSA: 8ng/ml; prostate weight: 47.8 g; GS: 7; and pathological stage: T2 in 64.5%, T3A in 25.5% and T3B in 10% of cases. Of the 157 evaluable slides, 79 and 78 had benign and cancer tissue, respectively. GS for the 37 cancer-positive cases were: 6 in 9, 7 in 18 and >7 in 10 and, in most instances, in concordance with final GS. In 40% of slides containing cancer, foci occupied ≥50% of block surface and 42% had a diameter ≥1 cm. Tissue was well preserved and consistently yielded RNA of very good quality with RNA Integrity Number (RIN) >7 for 97% of cases (mean=8.7±0.7) during the five-year collection period. This study confirms the high quality of randomly selected benign and cancerous fresh-frozen prostate tissues of the PROCURE Quebec Prostate Cancer Biobank. These results strengthen the uniqueness of this large prospective resource for prostate cancer research. PMID:24194978

  19. Institution Morphisms

    Science.gov (United States)

    Goguen, Joseph; Rosu, Grigore; Norvig, Peter (Technical Monitor)

    2001-01-01

    Institutions formalize the intuitive notion of logical system, including both syntax and semantics. A surprising number of different notions of morphisim have been suggested for forming categories with institutions as objects, and a surprising variety of names have been proposed for them. One goal of this paper is to suggest a terminology that is both uniform and informative to replace the current rather chaotic nomenclature. Another goal is to investigate the properties and interrelations of these notions. Following brief expositions of indexed categories, twisted relations, and Kan extensions, we demonstrate and then exploit the duality between institution morphisms in the original sense of Goguen and Burstall, and the 'plain maps' of Meseguer, obtaining simple uniform proofs of completeness and cocompleteness for both resulting categories; because of this duality, we prefer the name 'comorphism' over 'plain map.' We next consider 'theoroidal' morphisms and comorphisims, which generalize signatures to theories, finding that the 'maps' of Meseguer are theoroidal comorphisms, while theoroidal morphisms are a new concept. We then introduce 'forward' and 'semi-natural' morphisms, and appendices discuss institutions for hidden algebra, universal algebra, partial equational logic, and a variant of order sorted algebra supporting partiality.

  20. Studying and analyzing the formation and dynamics of the black cloud over Cairo, Egypt, using a multi sensor approach

    Science.gov (United States)

    El-Askary, H. M.; Prasad, A. K.; Marey, H. M.; El-Raey, M. E.; Asrar, G. R.; Kafatos, M.

    2012-04-01

    In the past decade, episodes of severe air pollution from biomass burning and/or industrial activities, known as the "black cloud" have occurred over Cairo, and the Nile Delta region situated on the eastern side of the Sahara desert in Egypt, during the autumn season. Previous studies have attributed the increased pollution levels during the black cloud season only to the biomass or open burning of agricultural waste, vehicular, industrial emissions, and secondary aerosols. However, new multi-sensor observations (column and vertical profiles) from satellites, dust transport models and associated meteorology present a different picture of the autumn pollution. It was found that the same region receives as well numerous dust storms along with the anthropogenic aerosols during same season. Such complex combination of these aerosols results in poor air quality and poses significant health hazards for the population in this region. In this study, data from the Moderate Resolution Imaging Spectrometer (MODIS) along with the Multiangle Imaging Spectroradiometer (MISR) are used with meteorological data and trajectory analyses to determine the cause of these events. MODIS fire counts highlighted the anthropogenic component of the dense cloud resulting from the burning of agricultural waste after harvest season. Synchronous MISR data show that these fires create low altitude (burning occurs at night, when a thermal inversion constrains the plumes to remain in the boundary layer (BL). Convection during the day raises the BL, dispersing these smoke particles until the next night. However, we have found a dust transport pathway along the Mauritania/Mali/Algeria/Libya/Egypt axis that significantly affects NE Africa, especially the Nile Delta region, during the biomass burning season. The increase in aerosol loading (A0D>0.9) along with corresponding decrease in the Angstrom Exponent, a typical feature of desert dust, point towards the presence of desert dust over the Delta