WorldWideScience

Sample records for cancer final technology assessment

  1. Thermionic conversion reactor technology assessment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1984-02-01

    The in-core thermionic space nuclear power supply may be the only identified reactor-power concept that can meet the SP-100 size functional requirements with demonstrated state-of-the-art reactor system and space-qualified power system component temperatures. The SP-100 configuration limits provide a net 40 m/sup 2/ of primary non-deployed radiator area. If a reasonable 7-year degradation allowance of 15% to 20% is provided then the beginning of life (BOL) net power output requirement is about 120 kWe. Consequently, the SP-100 power system must produce a P/A of 2.7 kWe/m/sup 2/. This non-deployed radiator area power density performance can only be reasonably achieved by the thermionic in-core convertr system, the potassium Rankine turbine system and the Stirling engine system. The purpose of this study is to examine past and current tests and data, and to assess the potential for successful development of suitable fueled-thermionic converters that will meet SP-100 and growth requirements. The basis for the assessment will be provided and the recommended key developments plan set forth.

  2. Thermionic conversion reactor technology assessment. Final report

    International Nuclear Information System (INIS)

    The in-core thermionic space nuclear power supply may be the only identified reactor-power concept that can meet the SP-100 size functional requirements with demonstrated state-of-the-art reactor system and space-qualified power system component temperatures. The SP-100 configuration limits provide a net 40 m2 of primary non-deployed radiator area. If a reasonable 7-year degradation allowance of 15% to 20% is provided then the beginning of life (BOL) net power output requirement is about 120 kWe. Consequently, the SP-100 power system must produce a P/A of 2.7 kWe/m2. This non-deployed radiator area power density performance can only be reasonably achieved by the thermionic in-core convertr system, the potassium Rankine turbine system and the Stirling engine system. The purpose of this study is to examine past and current tests and data, and to assess the potential for successful development of suitable fueled-thermionic converters that will meet SP-100 and growth requirements. The basis for the assessment will be provided and the recommended key developments plan set forth

  3. Zero-emission vehicle technology assessment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Woods, T.

    1995-08-01

    This is the final report in the Zero-Emission Vehicle (ZEV) Technology Assessment, performed for NYSERDA by Booz-Allen & Hamilton Inc. Booz-Allen wrote the final report, and performed the following tasks as part of the assessment: assembled a database of key ZEV organizations, their products or services, and plans; described the current state of ZEV technologies; identified barriers to widespread ZEV deployment and projected future ZEV technical capabilities; and estimated the cost of ZEVs from 1998 to 2004. Data for the ZEV Technology Assessment were obtained from several sources, including the following: existing ZEV industry publications and Booz-Allen files; major automotive original equipment manufacturers; independent electric vehicle manufacturers; battery developers and manufacturers; infrastructure and component developers and manufacturers; the U.S. Department of Energy, the California Air Resources Board, and other concerned government agencies; trade associations such as the Electric Power Research Institute and the Electric Transportation Coalition; and public and private consortia. These sources were contacted by phone, mail, or in person. Some site visits of manufacturers also were conducted. Where possible, raw data were analyzed by Booz-Allen staff and/or verified by independent sources. Performance data from standardized test cycles were used as much as possible.

  4. Assessment of the magnesium primary production technology. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Flemings, M.C.; Kenney, G.B.; Sadoway, D.R.; Clark, J.P.; Szekely, J.

    1981-02-01

    At current production levels, direct energy savings achievable in primary magnesium production are 1.2 milliquads of energy per annum. Were magnesium to penetrate the automotive market to an average level of 50 pounds per vehicle, the resultant energy savings at the production stage would be somewhat larger, but the resulting savings in gasoline would conserve an estimated 325 milliquads of energy per year. The principal barrier to more widespread use of magnesium in the immediate future is its price. A price reduction of magnesium of 10% would lead to widespread conversion of aluminum die and permanent mold castings to magnesium. This report addresses the technology of electrolytic and thermic magnesium production and the economics of expanded magnesium production and use.

  5. Oral cancer: molecular technologies for risk assessment and diagnosis

    Institute of Scientific and Technical Information of China (English)

    Wan Tao Chen

    2008-01-01

    @@ Purpose: The effective biomarkers related to diagnosis, metastasis, drug resistance and irradiation sensitivity of oral cancers will help the pathologist and oncologist to determine the molecular taxonomy diagnosis and design the individualization treatment for the patients with oral cancers.

  6. Review and assessments of potential environmental, health and safety impacts of MHD technology. Final draft

    Energy Technology Data Exchange (ETDEWEB)

    1978-01-01

    The purpose of this document is to develop an environmental, health and safety (EH and S) assessment and begin a site - specific assessment of these and socio - economic impacts for the magnetohydrodynamics program of the United States Department of Energy. This assessment includes detailed scientific and technical information on the specific EH and S issues mentioned in the MHD Environmental Development Plan. A review of current literature on impact-related subjects is also included. This document addresses the coal-fired, open-cycle MHD technology and reviews and assesses potential EH and S impacts resulting from operation of commercially-installed technology.

  7. Trialling computer touch-screen technology to assess psychological distress in patients with gynaecological cancer

    Directory of Open Access Journals (Sweden)

    Georgia Halkett

    2010-12-01

    Full Text Available BackgroundCancer impacts on the psychological well-being of many cancer patients. Appropriate tools can be used to assist health professionals in identifying patient needs and psychological distress. Recent research suggests that touchscreen technology can be used to administer surveys. The aim of this study was to evaluate the use of a touchscreen system in comparison to written questionnaires in a large tertiary hospital in Western Australia (WA.Method Patients who were scheduled to commence treatment for gynaecological cancer participated in this study. Patients were assigned to complete either a written questionnaire or the same survey using the touchscreen technology. Both methods of survey contained the same scales. All participants were asked to complete a follow-up patient satisfaction survey. Semi-structured interviews were conducted with health professionals to elicit views about the implementation of the technology and the available referral pathways. Data was analysed using descriptive statistics and content analysis. ResultsThirty patients completed the touchscreen questionnaires and an equal number completed the survey on paper. Participants who used the touchscreens were not significantly more satisfied than other participants. Four themes were noted in the interviews with health professionals: usability of technology, patients’ acceptance of technology, advantages of psychological screening and the value of the instruments included.ConclusionAlthough previous studies report that computerised assessments are a feasible option for assessing cancer patients’ needs, the data collected in this study demonstrates that the technology was not reliable with significant practical problems. The technology did not serve these patients better than pen and paper.

  8. Technology assessment of vertical and horizontal air drilling potential in the United States. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Carden, R.S.

    1993-08-18

    The objective of the research was to assess the potential for vertical, directional and horizontal air drilling in the United States and to evaluate the current technology used in air drilling. To accomplish the task, the continental United States was divided into drilling regions and provinces. The map in Appendix A shows the divisions. Air drilling data were accumulated for as many provinces as possible. The data were used to define the potential problems associated with air drilling, to determine the limitations of air drilling and to analyze the relative economics of drilling with air versus drilling mud. While gathering the drilling data, operators, drilling contractors, air drilling contractors, and service companies were contacted. Their opinion as to the advantages and limitations of air drilling were discussed. Each was specifically asked if they thought air drilling could be expanded within the continental United States and where that expansion could take place. The well data were collected and placed in a data base. Over 165 records were collected. Once in the data base, the information was analyzed to determine the economics of air drilling and to determine the limiting factors associated with air drilling.

  9. Waste management and proliferation: an assessment of technologies and policies relevant to nuclear power. Final report, June 1975--March 1977

    International Nuclear Information System (INIS)

    Some of the long-term hazards from radioactive waste management and the problems in safeguarding plutonium in a world moving toward a plutonium economy are presented. To ameliorate these problems, several alternative fuel cycle options are presented: homogeneous reactor, denatured thorium, open, tandem, accelerator-regenerative, co-processing, plutonium, spiking, and partitioning. An assessment is made of a variety of separation technologies applied to these options, including a review of 32 different reprocessing methods. The effects of these options on both U.S. and transnational policies regarding waste management and proliferation are examined. This study addresses the transnational environmental policy issues created by a worldwide nuclear industry and suggests the need for two international organizations: one to manage spent fuel and the breeder fuel cycle; the second to protect the global environment. Two photochemical schemes for improving existing reprocessing technology by reducing wastes and materials unaccounted for (MUF) are presented. The applicability of this technology, along with column chromatography, Talspeak, and other separation methods, is examined relative to various waste management alternatives including the partitioning and transmutation option. A computer model to determine the effectiveness of transmutation as a function of separation efficiency has been developed and employed. To estimate health impacts from various fuel cycle options, the Brookhaven energy system network simulator has been integrated with an atmospheric dispersion and pathway analysis model. Using revised 222Rn emission data, it is estimated from the linear hypothesis that the number of excess cancers is slightly less for the open than for the closed cycle. More importantly, the number of excess cancers induced by mill and mine tailings is from one to two times that caused by the rest of the entire fuel cycle

  10. Acoustic Separation Technology; FINAL

    International Nuclear Information System (INIS)

    Today's restrictive environmental regulations encourage paper mills to close their water systems. Closed water systems increase the level of contaminants significantly. Accumulations of solid suspensions are detrimental to both the papermaking process and the final products. To remove these solids, technologies such as flotation using dissolved air (DAF), centrifuging, and screening have been developed. Dissolved Air Flotation systems are commonly used to clarify whitewater. These passive systems use high pressure to dissolve air into whitewater. When the pressure is released, air micro-bubbles form and attach themselves to fibers and particles, which then float to the surface where they are mechanically skimmed off. There is an economic incentive to explore alternatives to the DAF technology to drive down the cost of whitewater processing and minimize the use of chemicals. The installed capital cost for a DAF system is significant and a typical DAF system takes up considerable space. An alternative approach, which is the subject of this project, involves a dual method combining the advantages of chemical flocculation and in-line ultrasonic clarification to efficiently remove flocculated contaminants from a water stream

  11. Establishment of a bioassay system for cancer risk assessment in energy technology

    Energy Technology Data Exchange (ETDEWEB)

    Ts' o, P.O.P.; Bruce, S.A.; Brown, A. (eds.)

    1983-09-01

    Separate abstracts were prepared for 20 papers in this report. For several years the Department of Energy (DOE), Office of Health and Environmental Research (OHER), has supported a research program aimed at developing new experimental approaches for the improvement of cancer risk assessments. The central issue is to overcome the organizational, species and other barriers that make it difficult to extrapolate laboratory-based data to predict risk to man. Most of the participants at the meeting are involved in research aimed at understanding the mechanism(s) of chemical carcinogenesis. Complex mixtures of chemicals are associated with many energy technologies. DOE's initial program emphasis focused on semi-applied research aimed at quantitative evaluation of carcinogenic activity of complex materials. Since much progress has been made in DOE integrated technology-specific chemical-biological characterization studies, the number and kinds of chemicals of concern has been reduced to a relatively few well-defined classes. Although the classes of compounds seem to be unique to some of the synfuel technologies, they are quite similar to compounds of general interest, for example, poly-nuclear aromatic hydrocarbons. Special emphasis was placed on molecular and cellular dosimetry as one of the key requirements for quantitative comparison of effects at the cell level in vivo and in vitro. Although it is relatively easy to measure cell, tissue, organ and whole organism doses associated with radiation exposures, we are just learning how to do this for chemical agents. Several methods have been developed in the past several years which can be used.

  12. Assessment of carbon-14 control technology and costs for the LWR fuel cycle. Final report

    International Nuclear Information System (INIS)

    The report is an effort to incorporate present knowledge of carbon-14 behavior in Light Water Reactors and Fuel Reprocessing Plants into Designs compatible with present technology. The impact of radioactive effluents are considered according to the traditional measure of maximum radiation dose to individuals, summation of individual annual doses to obtain a total population dose, and the environmental dose commitment. The sources of carbon-14 in LWR's and fuel reprocessing facilities are identified. Systems for the removal of carbon-14 in existing and future plants are addressed from both a technological and economic standpoint. Existing technology indicates that caustic scrubbing is the most cost-effective alternative for concurrently removing C-14 from waste-gas streams and leaving it in a form compatible with permanent disposal conditions

  13. Nuclear reactor maintenance technology assessment. Final summary report, September 16, 1978-September 15, 1979

    International Nuclear Information System (INIS)

    Nuclear power plants have exhibited a downtime of one day in four during the past decade. For mature LWR plants, 40% of this downtime is due to forced (unexpected) outages. These outages increase the loss of revenues and increase occupational radiation exposure. In 1979, the cost of maintenance of 70 operating plants was $1 billion per year. A fully remote maintenance technology would save 70% of this cost. PWR steam generator maintenance under fully remote system technology could save $270 million a year. BWR valve maintenance with fully remote technology could save $54,000,000 a year. Benefits for 150 plants by the early 1990's would be substantially higher; the total yearly savings would amount to $1.8 billion. The PWR steam generator would save $550 million while the BWR valve problem would save $140 million. For nuclear power plant maintenance, the vendors initially took steps to redesign and improve the reliability of the reactor system. The second step was to develop special maintenance tooling. The development of a generalized robotic manipulator having greater precision, dexterity, reliability, obstacle avoidance capability and load capacity is now feasible using microelectronics and computers. In order to drive this more general slave, the master controller must also be generalized to create a man-machine interface as transparent as possible; software modules must be developed which filter jitter, change scales, automaticaly control vision systems, and adapt force feedback signals in order to enhance the speed and precision of operation of the total system. A full complement of component technologies such as sensors, actuators, end-effectors, and remote TV vision systems must also be developed. Several other energy systems represent operations where such remote systems technology may be valuable

  14. An Assessment of the Status of Captive Broodstock Technology of Pacific Salmon, 1995 Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Flagg, Thomas A.; Mahnaken, Conrad V.W.; Hard, Jeffrey J.

    1995-06-01

    This report provides guidance for the refinement and use of captive broodstock technology for Pacific salmon (Oncorhynchus spp.) by bringing together information on the husbandry techniques, genetic risks, physiology, nutrition, and pathology affecting captive broodstocks. Captive broodstock rearing of Pacific salmon is an evolving technology, as yet without well defined standards. At present, we regard captive rearing of Pacific salmon as problematic: high mortality rates and low egg viability were common in the programs we reviewed for this report. One of the most important elements in fish husbandry is the culture environment itself. Many captive broodstock programs for Pacific salmon have reared fish from smolt-to-adult in seawater net-pens, and most have shown success in providing gametes for recovery efforts. However, some programs have lost entire brood years to diseases that transmitted rapidly in this medium. Current programs for endangered species of Pacific salmon rear most fish full-term to maturity in fresh well-water, since ground water is low in pathogens and thus helps ensure survival to adulthood. Our review suggested that captive rearing of fish in either freshwater, well-water, or filtered and sterilized seawater supplied to land-based tanks should produce higher survival than culture in seawater net-pens.

  15. Environmental Assessment For Cleanup and Closure of the Energy Technology Engineering Center. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2003-03-01

    DOE analyzed two cleanup and closure alternatives and the No Action Alternative, in accordance with the Council on Environmental Quality regulations implementing NEPA (40 CFR Parts 1500-1508) and DOE's NEPA implementing regulations (10 CFR Part 1021). Under Alternative 1, DOE is proposing to clean up the remaining ETEC facilities using the existing site specific cleanup standard of 15 mrem/yr. (plus DOE's As Low As Reasonably Achievable--ALARA-principle) for decontamination of radiological facilities and surrounding soils (Alternative 1). An annual 15-millirem additional radiation dose to the maximally exposed individual (assumed to be an individual living in a residential setting on Area IV) from all exposure pathways (air, soil, groundwater) equates to an additional theoretical lifetime cancer risk of no more than 3 x 10-4 (3 in 10,000). For perspective, it is estimated that the average individual in the United States receives a dose of about 300 millirem each year from natural sources of radiation. However, actual exposures generally will be much lower as a result of the application of the ''as low as reasonably achievable'' (ALARA) principle. Based on post-remediation verification sampling previous cleanups have generally resulted in a 2 x 10-6 level of residual risk. DOE would decontaminate, decommission, and demolish the remaining radiological facilities. DOE would also decommission and demolish the one remaining sodium facility and all of the remaining uncontaminated support buildings for which it is responsible. The ongoing RCRA corrective action program, including groundwater treatment (interim measures), would continue. Other environmental impacts would include 2.5 x 10-3 fatalities as a result of LLW shipments and 6.0 x 10-3 fatalities as a result of emission exhaust from all shipments. DOE would also decommission and demolish the remaining sodium facility and decommission and

  16. Technology assessments

    International Nuclear Information System (INIS)

    Theoretical studies in assessment methodology have concentrated in the past year on computerization of state-of-the-art models for internal radiation dosimetry and development and evaluation of environmental transport models. Methodology applications continued to cover a broad spectrum of radiation exposure scenarios. Potential exposure situations requiring assessment arise from assorted deployments of all parts of nuclear fuel cycles, including comparisons of alternative uranium and thorium based cycles, and preliminary evaluations of advanced reactor fuel concepts. Measurements and samples were collected characterizing and documenting the current radiological status of formerly used Manhattan Engineer District/Atomic Energy Commission (MED/AEC) sites. This survey program encompasses research activities in the areas of survey design, instrumentation development, sample analysis, and data reduction and analysis. Other laboratory activities within TAS center around the unique capabilities of the Health Physics Research Reactor (HPRR) as an irradiation source. Typically the HPRR was involved in testing and intercomparison of dosimetry and criticality alarm systems and in exposure of physical and biological experiments

  17. Assessment of technologies for hazardous waste site remediation: Non-treatment technologies and pilot scale facility implementation -- excavation -- storage technology -- safety analysis and review statement. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, H.R.; Overbey, W.K. Jr.; Koperna, G.J. Jr.

    1994-02-01

    The purpose of this study is to assess the state-of-the-art of excavation technology as related to environmental remediation applications. A further purpose is to determine which of the excavation technologies reviewed could be used by the US Corp of Engineers in remediating contaminated soil to be excavated in the near future for construction of a new Lock and Dam at Winfield, WV. The study is designed to identify excavation methodologies and equipment which can be used at any environmental remediation site but more specifically at the Winfield site on the Kanawha River in Putnam County, West Virginia. A technical approach was determined whereby a functional analysis was prepared to determine the functions to be conducted during the excavation phase of the remediation operations. A number of excavation technologies were identified from the literature. A set of screening criteria was developed that would examine the utility and ranking of the technologies with respect to the operations that needed to be conducted at the Winfield site. These criteria were performance, reliability, implementability, environmental safety, public health, and legal and regulatory compliance. The Loose Bulk excavation technology was ranked as the best technology applicable to the Winfield site. The literature was also examined to determine the success of various methods of controlling fugitive dust. Depending upon any changes in the results of chemical analyses, or prior remediation of the VOCs from the vadose zone, consideration should be given to testing a new ``Pneumatic Excavator`` which removes the VOCs liberated during the excavation process as they outgas from the soil. This equipment however would not be needed on locations with low levels of VOC emissions.

  18. Healthcare technology and technology assessment

    OpenAIRE

    Herndon, James H.; Hwang, Raymond; Bozic, K. H.

    2007-01-01

    New technology is one of the primary drivers for increased healthcare costs in the United States. Both physician and industry play important roles in the development, adoption, utilization and choice of new technologies. The Federal Drug Administration regulates new drugs and new medical devices, but healthcare technology assessment remains limited. Healthcare technology assessment originated in federal agencies; today it is decentralized with increasing private sector efforts. Innovation is ...

  19. Health technology assessment of cancer drugs in Canada, the United Kingdom and Australia: should the United States take notice?

    Science.gov (United States)

    Dranitsaris, George; Papadopoulos, George

    2015-06-01

    Cancer remains a global problem, with 7.5 million deaths annually, making it responsible for approximately 13% of deaths from all causes. Cancer also becomes more prevalent as the population ages, making it a major health policy challenge for many countries around the world. However, the encouraging news is that the number of cancer-related deaths has stabilized in many countries. At least part of this success may be attributed to improved diagnosis, early intervention strategies and the development of a newer class of anticancer agents, collectively called "targeted therapies", that are more specific in inhibiting key pathways in tumour genesis. However, these newer drugs are associated with a higher cost. As a result, expenditures for agents and cancer in general have been rising rapidly, far beyond the rate of inflation. Some view this as threatening the very health care systems themselves, which are integral to the modern social contract. Different countries have adopted unique mechanisms to facilitate patient access to these newer agents, with the intent of ensuring value for money and sustainability. In this review, cancer care policies and mechanisms for patient access to new drugs will be discussed and compared between select countries. Given its position as a country that allows free pharmaceutical pricing and multi-payer health insurance, the USA will be the reference country and will be compared with the UK, Canada and Australia, three countries with socialized health care systems and active health technology assessment programmes. PMID:25274258

  20. Assessing Technologies for Information-Seeking on Prostate Cancer Screening by Low-Income Men

    Directory of Open Access Journals (Sweden)

    Susan W. McRoy

    2014-11-01

    Full Text Available Purpose: This paper presents a multipart investigation of the benefits and challenges in deploying automated question-answering as an alternative to web-based searching to provide information about prostate cancer screening for low-income men age 40 years and older. Methods: The study comprised: 1 a survey assessing current use of the Internet, mobile phones and texting; 2 a controlled observational study of both web-based searching and automated question-answering for information about prostate cancer; and 3 a formative field study in which subjects interacted with a health department nurse using text messages. Results: Survey results suggest the target population has greater access to, and familiarity with, cell phones and text messaging compared to the Internet and web-based searching. Participants were significantly more confident using a cell phone and preferred to get health information through text messaging. Participants in the controlled observational study accepted the text messaging system, with most indicating it answered their questions, was easy to use and was a favorable tool for information-seeking. The field study also demonstrated potential for automated question-answering and text messaging to help the target population access health information. Conclusions: A two-way text messaging system has great potential to promote health communication and health information distribution. Participant interest in this system was high and did not seem to be specific to prostate cancer screening, suggesting that information about other topics, such as high blood pressure screening, could be provided similarly. We believe more investigations should be focused on this area, especially on benefits for the low-income community.

  1. Subcontract Report: Final Report on Assessment of Motor Technologies for Traction Drives of Hybrid and Electric Vehicles (Subcontract #4000080341)

    Energy Technology Data Exchange (ETDEWEB)

    Fezzler, Raymond [BIZTEK Consulting, Inc.

    2011-03-01

    Currently, interior permanent magnet (IPM) motors with rare-earth (RE) magnets are almost universally used for hybrid and electric vehicles (EVs) because of their superior properties, particularly power density. However, there is now a distinct possibility of limited supply or very high cost of RE magnets that could make IPM motors unavailable or too expensive. Because development of electric motors is a critical part of the U.S. Department of Energy (DOE) Advanced Power Electronics and Motors activity, DOE needs to determine which options should be investigated and what barriers should be addressed. Therefore, in order to provide a basis for deciding which research topics should be pursued, an assessment of various motor technologies was conducted to determine which, if any, is potentially capable of meeting FreedomCAR 2015 and 2020 targets. Highest priority was given to IPM, surface mounted permanent magnet (SPM), induction, and switched reluctance (SR) motors. Also of interest, but with lesser emphasis, were wheel motors, multiple-rotor motors, motors with external excitation, and several others that emerged from the assessment. Cost and power density (from a design perspective, the power density criterion translates to torque density) are emerging as the two most important properties of motors for traction drives in hybrid and EVs, although efficiency and specific power also are very important. The primary approach for this assessment involved interviews with original equipment manufacturers (OEMs), their suppliers, and other technical experts. For each technology, the following issues were discussed: (1) The current state-of-the-art performance and cost; (2) Recent trends in the technology; (3) Inherent characteristics of the motor - which ones limit the ability of the technology to meet the targets and which ones aid in meeting the target; (4) What research and development (R&D) would be needed to meet the targets; and (5) The potential for the technology to

  2. Ultrasound as an Adjunct to Mammography for Breast Cancer Screening: A Health Technology Assessment

    Science.gov (United States)

    2016-01-01

    Background Screening with mammography can detect breast cancer early, before clinical symptoms appear. Some cancers, however, are not captured with mammography screening alone. Ultrasound has been suggested as a safe adjunct screening tool that can detect breast cancers missed on mammography. We investigated the benefits, harms, cost-effectiveness, and cost burden of ultrasound as an adjunct to mammography compared with mammography alone for screening women at average risk and at high risk for breast cancer. Methods We searched Ovid MEDLINE, Ovid Embase, EBM Reviews, and the NHS Economic Evaluation Database, from January 1998 to June 2015, for evidence of effectiveness, harms, diagnostic accuracy, and cost-effectiveness. Only studies evaluating the use of ultrasound as an adjunct to mammography in the specified populations were included. We also conducted a cost analysis to estimate the costs in Ontario over the next 5 years to fund ultrasound as an adjunct to mammography in breast cancer screening for high-risk women who are contraindicated for MRI, the current standard of care to supplement mammography. Results No studies in average-risk women met the inclusion criteria of the clinical review. We included 5 prospective, paired cohort studies in high-risk women, 4 of which were relevant to the Ontario context. Adjunct ultrasound identified between 2.3 and 5.9 additional breast cancers per 1,000 screens. The average pooled sensitivity of mammography and ultrasound was 53%, a statistically significant increase relative to mammography alone (absolute increase 13%; P mammography screening alone. The GRADE for this body of evidence was low. Additional annual costs of using breast ultrasound as an adjunct to mammography for high-risk women in Ontario contraindicated for MRI would range from $15,500 to $30,250 in the next 5 years. Conclusions We found no evidence that evaluated the comparative effectiveness or diagnostic accuracy of screening breast ultrasound as an

  3. Assessing for Technological Literacy

    Science.gov (United States)

    Engstrom, Daniel E.

    2004-01-01

    Designing standards-based assessment is a key component of a quality technology education program. For students to become technologically literate, it is important that the teacher understands how to measure student understandings and abilities in the study of technology. This article is written to help teachers and teacher educators recognize the…

  4. Community-based assessment and planning of energy futures. Final report of the decentralized solar-energy technology-assessment program

    Energy Technology Data Exchange (ETDEWEB)

    Carnes, S.A.; Schweitzer, M.; Bronfman, B.H.

    1982-08-01

    Specific recommendations are given for attracting and retaining competent citizen participation in the local government assessment of technology. The role of information in decentralized energy planning and development is discussed. Positive results are listed as: increased local government and citizen interest; the high quality of policy options identified in plans; the comprehensiveness of the issues addressed; and the wealth of ideas generated for use in other communities. (PSB)

  5. Sludge technology assessment

    International Nuclear Information System (INIS)

    The retrieval, processing, and generation of final waste forms from radioactive tank waste sludges present some of the most challenging technical problems confronting scientists and engineers responsible for the waste management programs at the various Department of Energy laboratories and production facilities. Currently, the Department of Energy is developing a strategy to retrieve, process, and generate a final waste form for the sludge that meets the acceptance criteria for the final disposition. An integral part of this strategy will be use of separation processes that treat the sludge; the goal is to meet feed criteria for the various processes that will generate the final waste form, such as vitrification or grouting. This document is intended to (1) identify separation technologies which are being considered for sludge treatment at various DOE sites, (2) define the current state of sludge treatment technology, (3) identify what research and development is required, (4) identify current research programs within either DOE or academia developing sludge treatment technology, and (5) identify commercial separation technologies which may be applicable. Due to the limited scope of this document, technical evaluations regarding the need for a particular separations technology, the current state of development, or the research required for implementation, are not provided

  6. [Health technology assessment report. Use of liquid-based cytology for cervical cancer precursors screening].

    Science.gov (United States)

    Ronco, Guglielmo; Confortini, Massimo; Maccallini, Vincenzo; Naldoni, Carlo; Segnan, Nereo; Sideri, Mario; Zappa, Marco; Zorzi, Manuel; Calvia, Maria; Giorgi Rossi, Paolo

    2012-01-01

    OBJECTIVE OF THE PROJECT: Purpose of this Report is to evaluate the impact of the introduction of liquid-based cytology (LBC) in cervical cancer screening in terms of efficacy, undesired effects, costs and implications for organisation. EFFICACY AND UNDESIRED EFFECTS: LBC WITH MANUAL INTERPRETATION: The estimates of cross-sectional accuracy for high-grade intraepithelial neoplasia (CIN2 or more severe and CIN3 or more severe) obtained by a systematic review and meta-analysis published in 2008 were used. This review considered only studies in which all women underwent colposcopy or randomised controlled trials (RCTs) with complete verification of test positives. A systematic search of RCTs published thereafter was performed. Three RCTs were identified. One of these studies was conducted in 6 Italian regions and was of large size (45,174 women randomised); a second one was conducted in another Italian region (Abruzzo) and was of smaller size (8,654 women randomised); a third RCT was conducted in the Netherlands and was of large size (89,784 women randomised). No longitudinal study was available. There is currently no clear evidence that LBC increases the sensitivity of cytology and even less that its introduction increases the efficacy of cervical screening in preventing invasive cancers. The Italian randomised study NTCC showed a decrease in specificity, which was not observed in the other two RCTs available. In addition, the 2008 meta-analysis observed a reduction - even if minimal - in specificity just at the ASC-US cytological cut-off, but also a remarkable heterogeneity between studies. These results suggest that the effect of LBC on specificity is variable and plausibly related to the local style of cytology interpretation. There is evidence that LBC reduces the proportion of unsatisfactory slides, although the size of this effect varies remarkably. LBC WITH COMPUTER-ASSISTED INTERPRETATION: An Australian study, based on double testing, showed a statistically

  7. Horizontal oil well applications and oil recovery assessment. Volume 1: Success of horizontal well technology, Final report

    Energy Technology Data Exchange (ETDEWEB)

    Deskins, W.G.; McDonald, W.J.; Knoll, R.G.; Springer, S.J.

    1995-03-01

    Horizontal technology has been applied in over 110 formations in the USA. Volume I of this study addresses the overall success of horizontal technology, especially in less-publicized formations, i.e., other than the Austin Chalk, Bakken, and Niobrara. Operators in the USA. and Canada were surveyed on a formation-by-formation basis by means of a questionnaire. Response data were received describing horizontal well projects in 58 formations in the USA. and 88 in Canada. Operators responses were analyzed for trends in technical and economic success based on lithology (clastics and carbonates) and resource type (light oil, heavy oil, and gas). The potential impact of horizontal technology on reserves was also estimated. A forecast of horizontal drilling activity over the next decade was developed.

  8. Information technology resources assessment

    Energy Technology Data Exchange (ETDEWEB)

    Stevens, D.F. [ed.

    1992-01-01

    This year`s Information Technology Resources Assessment (ITRA) is something of a departure from traditional practice. Past assessments have concentrated on developments in fundamental technology, particularly with respect to hardware. They form an impressive chronicle of decreasing cycle times, increasing densities, decreasing costs (or, equivalently, increasing capacity and capability per dollar spent), and new system architectures, with a leavening of operating systems and languages. Past assessments have aimed -- and succeeded -- at putting information technology squarely in the spotlight; by contrast, in the first part of this assessment, we would like to move it to the background, and encourage the reader to reflect less on the continuing technological miracles of miniaturization in space and time and more on the second- and third-order implications of some possible workplace applications of these miracles. This Information Technology Resources Assessment is intended to provide a sense of technological direction for planners in projecting the hardware, software, and human resources necessary to support the diverse IT requirements of the various components of the DOE community. It is also intended to provide a sense of our new understanding of the place of IT in our organizations.

  9. Information technology resources assessment

    Energy Technology Data Exchange (ETDEWEB)

    Stevens, D.F. (ed.)

    1992-01-01

    This year's Information Technology Resources Assessment (ITRA) is something of a departure from traditional practice. Past assessments have concentrated on developments in fundamental technology, particularly with respect to hardware. They form an impressive chronicle of decreasing cycle times, increasing densities, decreasing costs (or, equivalently, increasing capacity and capability per dollar spent), and new system architectures, with a leavening of operating systems and languages. Past assessments have aimed -- and succeeded -- at putting information technology squarely in the spotlight; by contrast, in the first part of this assessment, we would like to move it to the background, and encourage the reader to reflect less on the continuing technological miracles of miniaturization in space and time and more on the second- and third-order implications of some possible workplace applications of these miracles. This Information Technology Resources Assessment is intended to provide a sense of technological direction for planners in projecting the hardware, software, and human resources necessary to support the diverse IT requirements of the various components of the DOE community. It is also intended to provide a sense of our new understanding of the place of IT in our organizations.

  10. Health care technology assessment

    Science.gov (United States)

    Goodman, Clifford

    1994-12-01

    The role of technology in the cost of health care is a primary issue in current debates concerning national health care reform. The broad scope of studies for understanding technological impacts is known as technology assessment. Technology policy makers can improve their decision making by becoming more aware, and taking greater advantage, of key trends in health care technology assessment (HCTA). HCTA is the systematic evaluation of the properties, impacts, and other attributes of health care technologies, including: technical performance; clinical safety and efficacy/effectiveness; cost-effectiveness and other economic attributes; appropriate circumstances/indications for use; and social, legal, ethical, and political impacts. The main purpose of HCTA is to inform technology-related policy making in health care. Among the important trends in HCTA are: (1) proliferation of HCTA groups in the public and private sectors; (2) higher standards for scientific evidence concerning technologies; (3) methodological development in cost analyses, health-related quality of life measurement, and consolidation of available scientific evidence (e.g., meta-analysis); (4) emphasis on improved data on how well technologies work in routine practice and for traditionally under-represented patient groups; (5) development of priority-setting methods; (6) greater reliance on medical informatics to support and disseminate HCTA findings.

  11. Information Technology Resources Assessment

    Energy Technology Data Exchange (ETDEWEB)

    1993-04-01

    The Information Technology Resources Assessment (ITRA) is being published as a companion document to the Department of Energy (DOE) FY 1994--FY 1998 Information Resources Management Long-Range Plan. This document represents a collaborative effort between the Office of Information Resources Management and the Office of Energy Research that was undertaken to achieve, in part, the Technology Strategic Objective of IRM Vision 21. An integral part of this objective, technology forecasting provides an understanding of the information technology horizon and presents a perspective and focus on technologies of particular interest to DOE program activities. Specifically, this document provides site planners with an overview of the status and use of new information technology for their planning consideration.

  12. The first step in the development of text mining technology for cancer risk assessment: identifying and organizing scientific evidence in risk assessment literature

    Directory of Open Access Journals (Sweden)

    Sun Lin

    2009-09-01

    Full Text Available Abstract Background One of the most neglected areas of biomedical Text Mining (TM is the development of systems based on carefully assessed user needs. We have recently investigated the user needs of an important task yet to be tackled by TM -- Cancer Risk Assessment (CRA. Here we take the first step towards the development of TM technology for the task: identifying and organizing the scientific evidence required for CRA in a taxonomy which is capable of supporting extensive data gathering from biomedical literature. Results The taxonomy is based on expert annotation of 1297 abstracts downloaded from relevant PubMed journals. It classifies 1742 unique keywords found in the corpus to 48 classes which specify core evidence required for CRA. We report promising results with inter-annotator agreement tests and automatic classification of PubMed abstracts to taxonomy classes. A simple user test is also reported in a near real-world CRA scenario which demonstrates along with other evaluation that the resources we have built are well-defined, accurate, and applicable in practice. Conclusion We present our annotation guidelines and a tool which we have designed for expert annotation of PubMed abstracts. A corpus annotated for keywords and document relevance is also presented, along with the taxonomy which organizes the keywords into classes defining core evidence for CRA. As demonstrated by the evaluation, the materials we have constructed provide a good basis for classification of CRA literature along multiple dimensions. They can support current manual CRA as well as facilitate the development of an approach based on TM. We discuss extending the taxonomy further via manual and machine learning approaches and the subsequent steps required to develop TM technology for the needs of CRA.

  13. Technology assessment of offshore industry and its impact on the maritime industry 1976-2000. Executive summary. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Durfee, J.H.

    1977-08-01

    This report contains a 25 year forecast of the offshore industry including offshore petroleum production, offshore power production, offshore mining, offshore service platforms, and commercial ocean fishing. Each segment of the offshore industry is described in terms of the current status of industry, trends that might influence the direction of future development, and forces acting on the industry to impede or encourage growth. The report examines potential areas of impact on the maritime industry, such as financial, manpower, environmental, materials requirements, legislation and regulation, and new technologies, that might result from offshore industry development. Further it discusses changes likely to result in the maritime industry from the various impacts described and suggests planning that will be needed to accommodate to the changes. The report provides a comprehensive analysis of the future of the offshore industry.

  14. Decontamination technology assessment

    International Nuclear Information System (INIS)

    This study was conducted by the Pacific Northwest Laboratory (PNL) for the U.S. Department of Energy (DOE) to identify and technically assess foreign decontamination and decommissioning (D and D) technology developments that may represent significant improvements over D and D technology currently available or under development in the United States. Technology need areas for nuclear power reactor decommissioning operations were identified and prioritized using the results of past light water rector (LWR) decommissioning studies to quantitatively evaluate the potential for reducing cost and decommissioning worker radiation dose for each major decommissioning activity. Based on these identified needs, current foreign D and D technologies of potential interest to the U.S. were identified through personal contacts and the collection and review of an extensive body of D and D literature. These technologies were then assessed qualitatively to evaluate their uniqueness, potential for a significant reduction in D and D costs and/or worker radiation dose, development status, and other factors affecting their value and applicability to U.S. needs

  15. Technology assessment. Pt. 1

    International Nuclear Information System (INIS)

    During its international winter meeting in Duesseldorf on 9th and 10th February, 1981, the Deutsches Atom-Forum tried to present a programme which did not only reflect the negative but also the positive aspects of the technology assessment. Acutally the Atom-Forum had intended to practice 'nuclear abstinence'. But since nuclear energy is a synonym for the risks of technology in public discussion this intention could not be fulfilled. Much too often the general topic of the meeting was shifted towards the discussion of nuclear energy. (orig.)

  16. Information technology resources assessment

    Energy Technology Data Exchange (ETDEWEB)

    Loken, S.C. [ed.

    1993-01-01

    The emphasis in Information Technology (IT) development has shifted from technology management to information management, and the tools of information management are increasingly at the disposal of end-users, people who deal with information. Moreover, the interactive capabilities of technologies such as hypertext, scientific visualization, virtual reality, video conferencing, and even database management systems have placed in the hands of users a significant amount of discretion over how these resources will be used. The emergence of high-performance networks, as well as network operating systems, improved interoperability, and platform independence of applications will eliminate technical barriers to the use of data, increase the power and range of resources that can be used cooperatively, and open up a wealth of possibilities for new applications. The very scope of these prospects for the immediate future is a problem for the IT planner or administrator. Technology procurement and implementation, integration of new technologies into the existing infrastructure, cost recovery and usage of networks and networked resources, training issues, and security concerns such as data protection and access to experiments are just some of the issues that need to be considered in the emerging IT environment. As managers we must use technology to improve competitiveness. When procuring new systems, we must take advantage of scalable resources. New resources such as distributed file systems can improve access to and efficiency of existing operating systems. In addition, we must assess opportunities to improve information worker productivity and information management through tedmologies such as distributed computational visualization and teleseminar applications.

  17. 25 CFR 575.9 - Final assessment.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Final assessment. 575.9 Section 575.9 Indians NATIONAL... § 575.9 Final assessment. (a) If the respondent fails to request a hearing as provided in part 577 of this chapter, the proposed civil fine assessment shall become a final order of the Commission....

  18. Exploiting rod technology. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-06-01

    ROD development was proceeding apace until recent budgetary decisions caused funding support for ROD development to be drastically reduced. The funding which was originally provided by DARPA and the Balanced Technology Initiative (BTI) Office has been cut back to zero from $800K. To determine the aeroballistic coefficients of a candidate dart, ARDEC is currently supporting development out of its own 6.2 funds at about $100K. ARDEC has made slow progress toward achieving this end because of failures in the original dart during testing. It appears that the next dart design to be tested will diverge from the original concept visualized by DARPA and Science and Technology Associates (STA). STA, the design engineer, takes exception to these changes on the basis of inappropriate test conditions and insufficient testing. At this time, the full resolution of this issue will be difficult because of the current management structure, which separates the developer (ARDEC) from the designer (STA).

  19. Nuclear Nonproliferation Ontology Assessment Team Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Strasburg, Jana D.; Hohimer, Ryan E.

    2012-01-01

    Final Report for the NA22 Simulations, Algorithm and Modeling (SAM) Ontology Assessment Team's efforts from FY09-FY11. The Ontology Assessment Team began in May 2009 and concluded in September 2011. During this two-year time frame, the Ontology Assessment team had two objectives: (1) Assessing the utility of knowledge representation and semantic technologies for addressing nuclear nonproliferation challenges; and (2) Developing ontological support tools that would provide a framework for integrating across the Simulation, Algorithm and Modeling (SAM) program. The SAM Program was going through a large assessment and strategic planning effort during this time and as a result, the relative importance of these two objectives changed, altering the focus of the Ontology Assessment Team. In the end, the team conducted an assessment of the state of art, created an annotated bibliography, and developed a series of ontological support tools, demonstrations and presentations. A total of more than 35 individuals from 12 different research institutions participated in the Ontology Assessment Team. These included subject matter experts in several nuclear nonproliferation-related domains as well as experts in semantic technologies. Despite the diverse backgrounds and perspectives, the Ontology Assessment team functioned very well together and aspects could serve as a model for future inter-laboratory collaborations and working groups. While the team encountered several challenges and learned many lessons along the way, the Ontology Assessment effort was ultimately a success that led to several multi-lab research projects and opened up a new area of scientific exploration within the Office of Nuclear Nonproliferation and Verification.

  20. Colorectal Cancer Risk Assessment Tool

    Science.gov (United States)

    ... know before using this tool: The Colorectal Cancer Risk Assessment Tool was designed for use by doctors and other health providers with their patients. If you are not a health ... your personal risk of colorectal cancer. (Colorectal cancer is another way ...

  1. Cancer Risk Prediction and Assessment

    Science.gov (United States)

    Cancer prediction models provide an important approach to assessing risk and prognosis by identifying individuals at high risk, facilitating the design and planning of clinical cancer trials, fostering the development of benefit-risk indices, and enabling estimates of the population burden and cost of cancer.

  2. Approaches to Assessing Technological Literacy

    Science.gov (United States)

    Pearson, Greg

    2006-01-01

    It is the conclusion of the Committee on Assessing Technological Literacy, a study panel appointed by the National Academy of Engineering and the National Research Council, that very little is known about what children or adults know, can do, and believe about technology. This is because the state of assessment related to technology--or, …

  3. Health technology assessment in Finland

    DEFF Research Database (Denmark)

    Mäkelä, Marjukka; Roine, Risto P

    2010-01-01

    Since the 1990s, health policy makers in Finland have been supportive of evidence-based medicine and approaches to implement its results. The Finnish Office for Health Technology Assessment (Finohta) has grown from a small start in 1995 to a medium-sized health technology assessment (HTA) agency,...... HTA findings. The Managed Uptake of Medical Methods program links the hospital districts to agree on introduction of technologies. The Ohtanen database provides Finnish-language summaries of major assessments made in other countries....

  4. Source characterization and control technology assessment of methylene chloride emissions from Eastman Kodak Company, Rochester, NY. Final report, July 1988-April 1989

    Energy Technology Data Exchange (ETDEWEB)

    Walata, S.A.; Rehm, R.M.

    1989-07-01

    This report gives results of an assessment of potential control technologies for methylene chloride (also known as dichloromethane or DCM) emission sources at Eastman Kodak Company's Kodak Park facility in Rochester, NY. DCM is a solvent used by Kodak in the manufacture of cellulose triacetate film support. Work has involved: a plant visit where major DCM emission sources were inspected, and evaluation of current and potential control technologies for the DCM emission sources. The report contains information gathered during the plant visit to the Kodak Park facility. Included are emission estimates determined by Kodak of all emission points greater than 8000 lb (3600 kg)/yr DCM, as well as a description of each point observed during the visit. Also included are results of an evaluation of control technologies that might be applied to the major emission sources. A cost analysis of different add-on control devices is provided for four of the uncontrolled emission points.

  5. Final Technical Report: Characterizing Emerging Technologies.

    Energy Technology Data Exchange (ETDEWEB)

    King, Bruce Hardison [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hansen, Clifford [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Stein, Joshua [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Riley, Daniel [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gonzalez, Sigifredo [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-12-01

    The Characterizing Emerging Technologies project focuses on developing, improving and validating characterization methods for PV modules, inverters and embedded power electronics. Characterization methods and associated analysis techniques are at the heart of technology assessments and accurate component and system modeling. Outputs of the project include measurement and analysis procedures that industry can use to accurately model performance of PV system components, in order to better distinguish and understand the performance differences between competing products (module and inverters) and new component designs and technologies (e.g., new PV cell designs, inverter topologies, etc.).

  6. Assessment of technologies essential to the application of advanced systems for process control. Research project TPS 75-625-1,2,3. Final report

    International Nuclear Information System (INIS)

    The report assesses the adequacy of certain underlying technologies which may be required for the successful design and implementation of ''advanced computer supported control rooms.'' The assessment is based upon the answers provided by Babcock and Wilcox, General Electric and the Institutt for Atomenergi to a detailed set of technical questions developed by EPRI (the questions and answers are documented in the Appendices to this report). Among the technical areas addressed are: definition and justification of functional and design requirements; information assimilation techniques; operability; validation; reliability; and maintenance capabilities. The report discusses the need for techniques to evaluate the impact of different design alternatives on operator performance, the increasing importance of software validation to assure adequate availability, and the role of utility personnel in the support of these systems

  7. Comparative assessment of hydrogen storage and international electricity trade for a Danish energy system with wind power and hydrogen/fuel cell technologies. Final project report

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen, Bent (Roskilde University, Energy, Environment and Climate Group, Dept. of Environmental, Social and Spatial Change (ENSPAC) (DK)); Meibom, P.; Nielsen, Lars Henrik; Karlsson, K. (Technical Univ. of Denmark, Risoe National Laboratory for Sustainable Energy, Systems Analysis Dept., Roskilde (DK)); Hauge Pedersen, A. (DONG Energy, Copenhagen (DK)); Lindboe, H.H.; Bregnebaek, L. (ea Energy Analysis, Copenhagen (DK))

    2008-02-15

    This report is the final outcome of a project carried out under the Danish Energy Agency's Energy Research Programme. The aims of the project can be summarized as follows: 1) Simulation of an energy system with a large share of wind power and possibly hydrogen, including economic optimization through trade at the Nordic power pool (exchange market) and/or use of hydrogen storage. The time horizon is 50 years. 2) Formulating new scenarios for situations with and without development of viable fuel cell technologies. 3) Updating software to solve the abovementioned problems. The project has identified a range of scenarios for all parts of the energy system, including most visions of possible future developments. (BA)

  8. Melter Technologies Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Perez, J.M. Jr. [Pacific Northwest National Lab., Richland, WA (United States); Schumacher, R.F. [Savannah River Technology Center, Aiken, SC (United States); Forsberg, C.W. [Oak Ridge National Lab., TN (United States)

    1996-05-01

    The problem of controlling and disposing of surplus fissile material, in particular plutonium, is being addressed by the US Department of Energy (DOE). Immobilization of plutonium by vitrification has been identified as a promising solution. The Melter Evaluation Activity of DOE`s Plutonium Immobilization Task is responsible for evaluating and selecting the preferred melter technologies for vitrification for each of three immobilization options: Greenfield Facility, Adjunct Melter Facility, and Can-In-Canister. A significant number of melter technologies are available for evaluation as a result of vitrification research and development throughout the international communities for over 20 years. This paper describes an evaluation process which will establish the specific requirements of performance against which candidate melter technologies can be carefully evaluated. Melter technologies that have been identified are also described.

  9. Power performance assessment. Final report

    International Nuclear Information System (INIS)

    In the increasingly commercialised wind power marketplace, the lack of precise assessment methods for the output of an investment is becoming a barrier for wider penetration of wind power. Thus, addressing this problem, the overall objectives of the project are to reduce the financial risk in investment in wind power projects by significantly improving the power performance assessment methods. Ultimately, if this objective is successfully met, the project may also result in improved tuning of the individual wind turbines and in optimisation methods for wind farm operation. The immediate, measurable objectives of the project are: To prepare a review of existing contractual aspects of power performance verification procedures of wind farms; to provide information on production sensitivity to specific terrain characteristics and wind turbine parameters by analyses of a larger number of wind farm power performance data available to the proposers; to improve the understanding of the physical parameters connected to power performance in complex environment by comparing real-life wind farm power performance data with 3D computational flow models and 3D-turbulence wind turbine models; to develop the statistical framework including uncertainty analysis for power performance assessment in complex environments; and to propose one or more procedures for power performance evaluation of wind power plants in complex environments to be applied in contractual agreements between purchasers and manufacturers on production warranties. Although the focus in this project is on power performance assessment the possible results will also be of benefit to energy yield forecasting, since the two tasks are strongly related. (au) JOULE III. 66 refs.; In Co-operation Renewable Energy System Ltd. (GB); Centre for Renewable Energy (GR); Aeronautic Research Centre (SE); National Engineering Lab. (GB); Public Power Cooperation (GR)

  10. Turbine imaging technology assessment

    Energy Technology Data Exchange (ETDEWEB)

    Moursund, R. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Carlson, T. J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2004-12-01

    The goal of this project was to identify and evaluate imaging technologies for observing juvenile fish within a Kaplan turbine, and specifically that would enable scientists to determine mechanisms of fish injury within an operating turbine unit. This report documents the opportunities and constraints for observing juvenile fish at specific locations during turbine passage. These observations were used to make modifications to dam structures and operations to improve conditions for fish passage while maintaining or improving hydropower production. The physical and hydraulic environment that fish experience as they pass through the hydroelectric plants were studied and the regions with the greatest potential for injury were defined. Biological response data were also studied to determine the probable types of injuries sustained in the turbine intake and what types of injuries are detectable with imaging technologies. The study grouped injury-causing mechanisms into two categories: fluid (pressure/cavitation, shear, turbulence) and mechanical (strike/collision, grinding/pinching, scraping). The physical constraints of the environment, together with the likely types of injuries to fish, provided the parameters needed for a rigorous imaging technology evaluation. Types of technology evaluated included both tracking and imaging systems using acoustic technologies (such as sonar and acoustic tags) and optic technologies (such as pulsed-laser videography, which is high-speed videography using a laser as the flash). Criteria for determining image data quality such as frame rate, target detectability, and resolution were used to quantify the minimum requirements of an imaging sensor.

  11. Ion exchange technology assessment report

    International Nuclear Information System (INIS)

    In the execution of its charter, the SRS Ion Exchange Technology Assessment Team has determined that ion exchange (IX) technology has evolved to the point where it should now be considered as a viable alternative to the SRS reference ITP/LW/PH process. The ion exchange media available today offer the ability to design ion exchange processing systems tailored to the unique physical and chemical properties of SRS soluble HLW's. The technical assessment of IX technology and its applicability to the processing of SRS soluble HLW has demonstrated that IX is unquestionably a viable technology. A task team was chartered to evaluate the technology of ion exchange and its potential for replacing the present In-Tank Precipitation and proposed Late Wash processes to remove Cs, Sr, and Pu from soluble salt solutions at the Savannah River Site. This report documents the ion exchange technology assessment and conclusions of the task team

  12. Inquiries and technological assessment

    International Nuclear Information System (INIS)

    The authors examine six Canadian inquiries to determine their values as scientific assessments, their ability to combine scientific data with policy considerations, and their effectiveness in extending public debate on scientific issues. Among the inquiries examined are the environmental assessment hearings into the Point Lepreau nuclear generating station, the Bayda inquiry into the Cluff Lake uranium mine, and the Porter commission on electric power planning in Ontario

  13. The Clinical Proteomic Technologies for Cancer | About

    Science.gov (United States)

    An objective of the Reagents and Resources component of NCI's Clinical Proteomic Technologies for Cancer Initiative is to generate highly characterized monoclonal antibodies to human proteins associated with cancer.

  14. The Clinical Proteomic Technologies for Cancer | Partners

    Science.gov (United States)

    An objective of the Reagents and Resources component of NCI's Clinical Proteomic Technologies for Cancer Initiative is to generate highly characterized monoclonal antibodies to human proteins associated with cancer.

  15. Assessment of Watershed Technologies

    OpenAIRE

    Lim Suan, Medel P.

    1999-01-01

    Dealing with various topics such as watershed classification, computer simulation and modeling and computer application in watershed research, this paper assembles and summarizes technologies that are currently being used or have potential for application in the Philippines. This is in the hope of helping watershed managers, planners and researchers.

  16. Lung cancer: assessing resectability

    OpenAIRE

    Quint, Leslie E

    2003-01-01

    Staging classification in patients with non-small cell lung cancer does not always correlate perfectly with surgical resectability. Therefore, it is important to evaluate individual features of a patient’s tumor in order to determine if surgical resection is the optimal method of treatment, regardless of tumor stage. Such features include characteristics of the primary tumor, regional lymph nodes and distant sites.

  17. Technology readiness assessments: A retrospective

    Science.gov (United States)

    Mankins, John C.

    2009-11-01

    The development of new system capabilities typically depends upon the prior success of advanced technology research and development efforts. These systems developments inevitably face the three major challenges of any project: performance, schedule and budget. Done well, advanced technology programs can substantially reduce the uncertainty in all three of these dimensions of project management. Done poorly, or not at all, and new system developments suffer from cost overruns, schedule delays and the steady erosion of initial performance objectives. It is often critical for senior management to be able to determine which of these two paths is more likely—and to respond accordingly. The challenge for system and technology managers is to be able to make clear, well-documented assessments of technology readiness and risks, and to do so at key points in the life cycle of the program. In the mid 1970s, the National Aeronautics and Space Administration (NASA) introduced the concept of "technology readiness levels" (TRLs) as a discipline-independent, programmatic figure of merit (FOM) to allow more effective assessment of, and communication regarding the maturity of new technologies. In 1995, the TRL scale was further strengthened by the articulation of the first definitions of each level, along with examples (J. Mankins, Technology readiness levels, A White Paper, NASA, Washington, DC, 1995. [1]). Since then, TRLs have been embraced by the U.S. Congress' General Accountability Office (GAO), adopted by the U.S. Department of Defense (DOD), and are being considered for use by numerous other organizations. Overall, the TRLs have proved to be highly effective in communicating the status of new technologies among sometimes diverse organizations. This paper will review the concept of "technology readiness assessments", and provide a retrospective on the history of "TRLs" during the past 30 years. The paper will conclude with observations concerning prospective future

  18. Forest Technology Program Outcome Assessment

    OpenAIRE

    Bartholomay, G. Andrew

    2010-01-01

    Course grades are the norm for reporting a student’s overall proficiency. However, the one dimensional nature of grades implies that all individual course components have been equally mastered. The Pennsylvania College of Technology employs an institution wide program of Quality Through Assessment to aid in evaluating the institutional mission to, “provide students with quality academic programs that respond to economic and employment realities” (www.pct.edu/assessment/). The initiative emplo...

  19. Foreshore Assessment using Space Technology

    OpenAIRE

    2014-01-01

    FORESHORE ASSESSMENT USING SPACE TECHNOLOGY. Vegetated foreshores and floodplains provide important ecosystem services. These include benefits for coastal defence: the foreshores attenuate waves, enhance sedimentation and reduce erosion, mitigating flood risk. At present, this function of wetland ecosystems is hardly incorporated in coastal defence schemes. Yet considering foreshores and floodplains in water safety assessments and in levee design can result in considerable cost reductions for...

  20. Quantification of environmental impacts of various energy technologies. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Selfors, A. [ed.

    1994-10-01

    This report discusses problems related to economic assessment of the environmental impacts and abatement measures in connection with energy projects. Attention is called to the necessity of assessing environmental impacts both in the form of reduced economic welfare and in the form of costs of abatement measures to reduce the impact. In recent years, several methods for valuing environmental impacts have been developed, but the project shows that few empirical studies have been carried out. The final report indicates that some important factors are very difficult to evaluate. In addition environmental impacts of energy development in Norway vary considerably from project to project. This makes it difficult to obtain a good basis for comparing environmental impacts caused by different technologies, for instance hydroelectric power versus gas power or wind versus hydroelectric power. It might be feasible however to carry out more detailed economic assessments of environmental impacts of specific projects. 33 refs., 1 fig., 4 tabs.

  1. Knowledge in health technology assessment

    DEFF Research Database (Denmark)

    Tjørnhøj-Thomsen, Tine; Hansen, Helle Ploug

    2011-01-01

    Health systems are placing more and more emphasis on designing and delivering services that are focused on the patient, and there is a growing interest in patient aspects of health policy research and health technology assessment (HTA). Only a few HTA agencies use and invest in scientific methods...... to generate knowledge and evidence about the patient aspects of a given technology. This raises questions about how knowledge is produced in HTA reports and what kind of knowledge is considered relevant. This article uses a Danish HTA on patient education from 2009 as empirical material for a...

  2. Augmented Reality Tower Technology Assessment

    Science.gov (United States)

    Reisman, Ronald J.; Brown, David M.

    2009-01-01

    Augmented Reality technology may help improve Air Traffic Control Tower efficiency and safety during low-visibility conditions. This paper presents the assessments of five off-duty controllers who shadow-controlled' with an augmented reality prototype in their own facility. Initial studies indicated unanimous agreement that this technology is potentially beneficial, though the prototype used in the study was not adequate for operational use. Some controllers agreed that augmented reality technology improved situational awareness, had potential to benefit clearance, control, and coordination tasks and duties and could be very useful for acquiring aircraft and weather information, particularly aircraft location, heading, and identification. The strongest objections to the prototype used in this study were directed at aircraft registration errors, unacceptable optical transparency, insufficient display performance in sunlight, inadequate representation of the static environment and insufficient symbology.

  3. Constructive Technology Assessment (CTA) as a tool in Coverage with Evidence Development: The case of the 70-gene prognosis signature for breast cancer diagnostics

    NARCIS (Netherlands)

    V.P. Retèl; J.M. Bueno-de-Mesquita; M.J.M. Hummel; M.J. van de Vijver; K.F.L. Douma; K. Karsenberg; F.S.A.M. van Dam; C. van Krimpen; F.E. Bellot; R.M.H. Roumen; S.C. Linn; W.H. van Harten

    2009-01-01

    Objectives: Constructive Technology Assessment (CTA) is a means to guide early implementation of new developments in society, and can be used as an evaluation tool for Coverage with Evidence Development (CED). We used CTA for the introduction of a new diagnostic test in the Netherlands, the 70-gene

  4. Colon Cancer Risk Assessment - Gauss Program

    Science.gov (United States)

    An executable file (in GAUSS) that projects absolute colon cancer risk (with confidence intervals) according to NCI’s Colorectal Cancer Risk Assessment Tool (CCRAT) algorithm. GAUSS is not needed to run the program.

  5. Smart Gun Technology project. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Weiss, D.R.

    1996-05-01

    The goal of the Smart Gun Technology project is to eliminate the capability of an unauthorized user form firing a law officer`s firearm by implementing user-recognizing-and-authorizing (or {open_quotes}smart{close_quotes}) surety technologies. This project was funded by the National Institute of Justice. This report lists the findings and results of the project`s three primary objectives. First, to find and document the requirements for a smart firearm technology that law enforcement officers will value. Second, to investigate, evaluate, and prioritize technologies that meet the requirements for a law enforcement officer`s smart firearm. Third, to demonstrate and document the most promising technology`s usefulness in models of a smart firearm.

  6. Technology assessment with regard to the environment. Assessment of the consequences of legislation for environment protection shown for the example of the Law on Chemicals. Final report; Technikfolgenabschaetzung - Umwelt. Gesetzesfolgenabschaetzung im Umweltschutz. Untersuchung am Beispiel des Chemikaliengesetzes. Endbericht

    Energy Technology Data Exchange (ETDEWEB)

    Schulte-Hostede, S.

    1993-12-31

    The present report contains the result of a research project on `Technology assessment with regard to the environment` which was commissioned by the Federal Ministry for Research and Technology (BMFT) and carried out jointly by the GSF Research Centre for Environment and Health (GSF) and the Institute for Applied Innovation Research (IAI). In this project the Law on Protection from Harzardous Substances (Law on Chemicals) was used to exemplify the procedure of assessing the consequences of legislation in the area of environmental law. The project proposal distinguished three project phases. In the first an exemplary ex post analysis was to be carried out on a significant legal regulation (the Law on Chemicals) concerning a specific branch of industry generally considered innovative (the chemical industry). In this way it was intended to collect empirical knowledge on how regulations affect innovation processes in the individual company. In the second phase the planned amendment of the Law on Chemicals was to serve as a case example for an assessment of the consequences of legislation. In the third project phase the methodology employed in the former was to be extended for the purpose of developing an instrumentarium for the ex ante assessment of legislation. Such an instrument could permit both the corporate innovator and the innovation promoter to assess the effets of environmental legislation at the corporate level and thus develop an anticipatory conflict management. (orig./SR) [Deutsch] Der vorgelegte Bericht beinhaltet die Ergebnisse des vom GSF-Forschungszentrum fuer Umwelt und Gesundheit (GSF) und dem Institut fuer Angewandte Innovationsforschung (IAI) gemeinsam bearbeiteten BMFT-Forschungsvorhabens `Technikfolgenabschaetzung - Umwelt`. Thema war die Gesetzesfolgenabschaetzung im Bereich der Umweltschutzgesetzgebung am Beispiel des `Gesetzes zum Schutz vor gefaehrlichen Stoffen (Chemikaliengesetz)`. Der Projektvorschlag sah dabei vor, zunaechst in einer

  7. Assessment of technologies for CO{sub 2} capture and storage. Final report; Verfahren zur CO{sub 2}-Abscheidung und -Speicherung. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Radgen, Peter; Cremer, Clemens; Warkentin, Sebastian [Fraunhofer-Inst. fuer Systemtechnik und Innovationsforschung, Karlsruhe (Germany); Gerling, Peter; May, Franz; Knopf, Stephan [Bundesanstalt fuer Geowissenschaften und Rohstoffe, Hannover (Germany)

    2006-08-15

    The aim of this study was to summarize the actual status for carbon capture, transport and storage for CO{sub 2} emissions from power stations. Special interest was given to the implications from the introduction of carbon capture and storage in power stations on the efficiency, emissions and cost for electricity generation. In the beginning a detailed analyses of the national, European and international activities in this field have been conducted. The analysis focussed on the identification of main actors and the different co-operation of actors. To do so, the available literature has been studied and analysed with a bibliometric approach, which has taken also presentations at national and international conferences into account. In a second step a technical analysis has been undertaken for the three main routes for carbon capture (pre-combustion capture; post-combustion capture, oxy-fuel combustion) with a special emphasis on the impact to the Environment. Truck, ship and pipeline transport have been analysed as means for transporting the CO{sub 2} from the power station to the storage site. In addition the different storage options for a secure long term storage of the captured CO{sub 2} are studied in the report. Special attention was given to the storage options in gasfields and saline aquifers which will be the most promising options in Germany. The report gives an actual overview on the status of carbon capture and storage in the world. It therefore supports the decision making process when introducing this new technology, taking into account the environmental effects. (orig.)

  8. Innovative Technology Development Program. Final summary report

    International Nuclear Information System (INIS)

    Through the Office of Technology Development (OTD), the U.S. Department of Energy (DOE) has initiated a national applied research, development, demonstration, testing, and evaluation program, whose goal has been to resolve the major technical issues and rapidly advance technologies for environmental restoration and waste management. The Innovative Technology Development (ITD) Program was established as a part of the DOE, Research, Development, Demonstration, Testing, and Evaluation (RDDT ampersand E) Program. The plan is part of the DOE's program to restore sites impacted by weapons production and to upgrade future waste management operations. On July 10, 1990, DOE issued a Program Research and Development Announcement (PRDA) through the Idaho Operations Office to solicit private sector help in developing innovative technologies to support DOE's clean-up goals. This report presents summaries of each of the seven projects, which developed and tested the technologies proposed by the seven private contractors selected through the PRDA process

  9. Fuzzy sets applications for cancer risk assessment.

    Science.gov (United States)

    Molchanov, P A; Dudatiev, A V; Podobna, Y Y; Molchanova, O P

    2002-09-01

    The method of cancer risk assessment on the basis of the Fuzzy Set Theory is presented. The method is based on a multifactor risk assessment of cancer diseases. The individual risk of cancer disease is evaluated as the probability of disease multiplied by the value of an individual dose. An acupuncture method of cancer risk assessments was developed. The method is based on the analysis of changes of an electromagnetic field (biofield) of a person. The method allows to determine both cancer probability and probable location of the process. PMID:12298344

  10. Risk assessment meta tool LDRD final report.

    Energy Technology Data Exchange (ETDEWEB)

    Bouchard, Ann Marie; Osbourn, Gordon Cecil

    2006-12-01

    The goal of this project was to develop a risk analysis meta tool--a tool that enables security analysts both to combine and analyze data from multiple other risk assessment tools on demand. Our approach was based on the innovative self-assembling software technology under development by the project team. This technology provides a mechanism for the user to specify his intentions at a very high level (e.g., equations or English-like text), and then the code self-assembles itself, taking care of the implementation details. The first version of the meta tool focused specifically in importing and analyzing data from Joint Conflict and Tactical Simulation (JCATS) force-on-force simulation. We discuss the problem, our approach, technical risk, and accomplishments on this project, and outline next steps to be addressed with follow-on funding.

  11. HVDC power transmission technology assessment

    Energy Technology Data Exchange (ETDEWEB)

    Hauth, R.L.; Tatro, P.J.; Railing, B.D. [New England Power Service Co., Westborough, MA (United States); Johnson, B.K.; Stewart, J.R. [Power Technologies, Inc., Schenectady, NY (United States); Fink, J.L.

    1997-04-01

    The purpose of this study was to develop an assessment of the national utility system`s needs for electric transmission during the period 1995-2020 that could be met by future reduced-cost HVDC systems. The assessment was to include an economic evaluation of HVDC as a means for meeting those needs as well as a comparison with competing technologies such as ac transmission with and without Flexible AC Transmission System (FACTS) controllers. The role of force commutated dc converters was to be assumed where appropriate. The assessment begins by identifying the general needs for transmission in the U.S. in the context of a future deregulated power industry. The possible roles for direct current transmission are then postulated in terms of representative scenarios. A few of the scenarios are illustrated with the help of actual U.S. system examples. non-traditional applications as well as traditional applications such as long lines and asynchronous interconnections are discussed. The classical ``break-even distance`` concept for comparing HVDC and ac lines is used to assess the selected scenarios. The impact of reduced-cost converters is reflected in terms of the break-even distance. This report presents a comprehensive review of the functional benefits of HVDC transmission and updated cost data for both ac and dc system components. It also provides some provocative thoughts on how direct current transmission might be applied to better utilize and expand our nation`s increasingly stressed transmission assets.

  12. Assessing resectability of lung cancer

    International Nuclear Information System (INIS)

    In order to assess the value of computed tomography (CT) of the mediastinum, upper abdomen and head in the assessment of resectability of lung cancer, the CT findings of 262 patients, of whom 198 underwent thoracotomy, were anlyzed retrospectively and the stagings obtained at CT and thoracotomy were compared. Mediastinal CT reliably predicted resectability when there was no evidence of mediastinal involvement. However, it was often impossible to determine whether tumour with apparent mediastinal infiltration on CT was resectable or not. The sole finding of lymph node enlargement did not permit differentiation of benign from malignant lymphadenopathy when the lymph node diameter as < 25 mm and the lymphadenopathy was confined to one lymph node station. Upper abdominal metastases were found in 6.1% and brain metastases in 4.6% of patients and neither the histological type nor other features of the tumour were found to be useful predictors of their presence. The large number of non-specific findings decreased the utility of abdominal CT. The appropriate strategy for the pre-operative evaluation of patients with lung cancer is discussed. (author). 29 refs.; 1 fig.; 10 tabs

  13. Technology transfer pilot study. Final report

    International Nuclear Information System (INIS)

    Four specific technologies based on the Initial Fusion Program were targeted for this initial study. The areas chosen were the CO2 laser, high pressure from cleaning, video multiplexer, and plans-optics polishing. The study concluded that both Government and Industry are willing and anxious to promote and to reap the benefits of technology transfer. Recommendations were made in the areas of patent policy, documentation procedures in the transfer process, awareness training, and expansion of the scope of the study. 18 refs

  14. Security Assessment Simulation Toolkit (SAST) Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Meitzler, Wayne D.; Ouderkirk, Steven J.; Hughes, Chad O.

    2009-11-15

    The Department of Defense Technical Support Working Group (DoD TSWG) investment in the Pacific Northwest National Laboratory (PNNL) Security Assessment Simulation Toolkit (SAST) research planted a technology seed that germinated into a suite of follow-on Research and Development (R&D) projects culminating in software that is used by multiple DoD organizations. The DoD TSWG technology transfer goal for SAST is already in progress. The Defense Information Systems Agency (DISA), the Defense-wide Information Assurance Program (DIAP), the Marine Corps, Office Of Naval Research (ONR) National Center For Advanced Secure Systems Research (NCASSR) and Office Of Secretary Of Defense International Exercise Program (OSD NII) are currently investing to take SAST to the next level. PNNL currently distributes the software to over 6 government organizations and 30 DoD users. For the past five DoD wide Bulwark Defender exercises, the adoption of this new technology created an expanding role for SAST. In 2009, SAST was also used in the OSD NII International Exercise and is currently scheduled for use in 2010.

  15. Systems Dynamics Use for Technologies Assessment

    OpenAIRE

    Ginters, Egils; Barkane, Zane; Vincent, Hugues

    2010-01-01

    International audience Elaboration and introduction of a new technology is a complex and expensive task therefore it is necessary to assess the set of factors influencing the future of technology during the stages of technology emergence and development. The most important parameters of assessment are acceptance and sustainability of technology. Different models exist, but mostly they are static and do not offer possibilities for dynamic assessment in real time and do not forecast the sust...

  16. Technology-assisted dietary assessment

    Science.gov (United States)

    Zhu, Fengqing; Mariappan, Anand; Boushey, Carol J.; Kerr, Deb; Lutes, Kyle D.; Ebert, David S.; Delp, Edward J.

    2008-02-01

    Dietary intake provides valuable insights for mounting intervention programs for prevention of disease. With growing concern for adolescent obesity, the need to accurately measure diet becomes imperative. Assessment among adolescents is problematic as this group has irregular eating patterns and have less enthusiasm for recording food intake. Preliminary studies among adolescents suggest that innovative use of technology may improve the accuracy of diet information from young people. In this paper, we propose a novel food record method using a mobile device that will provide an accurate account of daily food and nutrient intake among adolescents. Our approach includes the use of image analysis tools for identification and quantification of food consumption. Images obtained before and after food is consumed can be used to estimate the diet of an individual. In this paper we describe our initial results and indicate the potential of the proposed system.

  17. Technology assessment using NBIC convergence

    International Nuclear Information System (INIS)

    Technologies' has considerably influenced scientific and social thinking about the future, there are several active debates in progress. The first being about the future of technologies and their relations to humans as nanoscale materials and systems provide the means to probe cells and provide basis for human performance augmentation - hence contributing to the formation of political and public opinion on societal aspects of science and technology. Such debates have lead to socio-political and ethical issues that transcend academic disciplinary borders that are rooted outside of the scientific arena. Thus it necessitates, inter- and often trans-disciplinary research to contribute effectively to these formative process. Such concerns are independently addressed using studies relating to toxicology, fate, transport, and bioavailability of nanomaterials, as well as human exposures to these materials. On another front, the debate is on the future of the scientific disciplines and visions about technological developments. Such predictions often relate to human way of life, environmental and international security, and are used by scientists, engineers, managers, policymakers, media, philosophers and authors - all with different interpretations. We present balanced, yet strategic assessments and recommendations of revolutionary scientific breakthroughs in multidisciplinary environments based on the NBIC convergence approach. Technology roadmaps are cautiously formulated based on extensive research, expert elicitation, and networking approaches to project 'future scenarios' realistically and epistemologically. Such roadmaps enable development of transformative tools and methodologies that fill fundamental knowledge gaps, and change culture in academia to foster collaboration, thus providing unique solutions. It is expected that the synergy arising from converging technologies and research methodologies at the IASC will leverage emerging and potentially transformative studies. The

  18. ELECTRIC INFRASTRUCTURE TECHNOLOGY, TRAINING, AND ASSESSMENT PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    TREMEL, CHARLES L

    2007-06-28

    The objective of this Electric Infrastructure Technology, Training and Assessment Program was to enhance the reliability of electricity delivery through engineering integration of real-time technologies for wide-area applications enabling timely monitoring and management of grid operations. The technologies developed, integrated, tested and demonstrated will be incorporated into grid operations to assist in the implementation of performance-based protection/preventive measures into the existing electric utility infrastructure. This proactive approach will provide benefits of reduced cost and improved reliability over the typical schedule-based and as needed maintenance programs currently performed by utilities. Historically, utilities have relied on maintenance and inspection programs to diagnose equipment failures and have used the limited circuit isolation devices, such as distribution main circuit breakers to identify abnormal system performance. With respect to reliable problem identification, customer calls to utility service centers are often the sole means for utilities to identify problem occurrences and determine restoration methodologies. Furthermore, monitoring and control functions of equipment and circuits are lacking; thus preventing timely detection and response to customer outages. Finally, the two-way flow of real-time system information is deficient, depriving decision makers of key information required to effectively manage and control current electric grid demands to provide reliable customer service in abnormal situations. This Program focused on advancing technologies and the engineering integration required to incorporate them into the electric grid operations to enhance electrical system reliability and reduce utility operating costs.

  19. Uranium miner lung cancer study. Final report

    International Nuclear Information System (INIS)

    This study on uranium miners was started in 1957 and extended through June 30, 1986. It consisted of the routine screening of sputum from uranium miners of the Colorado Plateau, and collection of surgical and autopsy material from uranium miners who developed lung cancer. The projects resulted in: (1) Proof, for the first time, that cancer takes from 10 to 15 years to develop from the maximum accumulated carcinogenic insult and can be demonstrated through progressive cellular changes of the bronchial tree; (2) Development of a method for preserving, concentrating, and processing sputum samples. This is known as the Saccomanno Technique, and is used worldwide in diagnosing lung cancer; (3) Publication of the 1st and 2nd editions of a full-color textbook entitled ''Diagnostic Pulmonary Cytology;'' (4) Presentation of conclusive data on the effects of cigarette smoking and alpha progeny radiation on uranium miners, and information on safe radiation exposure levels; (5) Development of a brush-wash tube for collecting, concentrating, and preparing bronchial brushings and washings; (6) Development of cytological criteria which has improved sensitivity from 30% to about 60%; (7) Development of criteria for cytologic identification of carcinoma in situ, making it possible to diagnose lung cancer before it can be detected on chest x-ray

  20. Development of Advanced Ceramic Manufacturing Technology; FINAL

    International Nuclear Information System (INIS)

    Advanced structural ceramics are enabling materials for new transportation engine systems that have the potential for significantly reducing energy consumption and pollution in automobiles and heavy vehicles. Ceramic component reliability and performance have been demonstrated in previous U.S. DOE initiatives, but high manufacturing cost was recognized as a major barrier to commercialization. Norton Advanced Ceramics (NAC), a division of Saint-Gobain Industrial Ceramics, Inc. (SGIC), was selected to perform a major Advanced Ceramics Manufacturing Technology (ACMT) Program. The overall objectives of NAC's program were to design, develop, and demonstrate advanced manufacturing technology for the production of ceramic exhaust valves for diesel engines. The specific objectives were (1) to reduce the manufacturing cost by an order of magnitude, (2) to develop and demonstrate process capability and reproducibility, and (3) to validate ceramic valve performance, durability, and reliability. I n order to achieve these objectives, NAC, a leading U.S. advanced ceramics component manufacturer, assembled a multidisciplinary, vertically integrated team. This team included: a major diesel engine builder, Detroit Diesel Corporation (DDC); a corporate ceramics research division, SGIC's Northboro R and D Center; intelligent processing system developers, BDM Federal/MATSYS; a furnace equipment company, Centorr/Vacuum Industries; a sintering expert, Wittmer Consultants; a production OEM, Deco-Grand; a wheel manufacturer and grinding operation developer, Norton Company's Higgins Grinding Technology Center (HGTC); a ceramic machine shop, Chand Kare Technical Ceramics; and a manufacturing cost consultant, IBIS Associates. The program was divided into four major tasks: Component Design and Specification, Component Manufacturing Technology Development, Inspection and Testing, and Process Demonstration

  1. Genetic cancer risk assessment in practice

    International Nuclear Information System (INIS)

    The advent of genetic testing has made a dramatic impact on the management of individuals with inherited susceptibility to cancer and their relatives. Genetic counsel ing, with or without testing, is warranted when clues to familial cancer are recognized. Today, genetic testing for classic cancer genetic syndromes is now the standard of care, and has been complemented by genetic testing for other situations commonly encountered in clinical practice. Genetic testing for colorectal cancer, breast cancer, kidney cancer, thyroid cancer, melanoma, and pancreatic cancer raise important issues about the parameters for testing. Genetic cancer risk assessment can lead to measurable reductions in morbidity and mortality through strategies that rely on surveillance, chemo prevention, and risk-reducing surgery

  2. Ethical perspectives on health technology assessment.

    NARCIS (Netherlands)

    Have, H.A.M.J. ten

    2004-01-01

    This study analyses why ethical aspects play a minor role in health technology assessment (HTA) studies, even when comprehensive approaches of technology assessment are advocated. Technology is often regarded as a value-neutral tool. At the same time, bioethics is dominated by an engineering model.

  3. ADVANCED RECIPROCATING COMPRESSION TECHNOLOGY (ARCT). FINAL REPORT

    International Nuclear Information System (INIS)

    The U.S. natural gas pipeline industry is facing the twin challenges of increased flexibility and capacity expansion. To meet these challenges, the industry requires improved choices in gas compression to address new construction and enhancement of the currently installed infrastructure. The current fleet of installed reciprocating compression is primarily slow-speed integral machines. Most new reciprocating compression is and will be large, high-speed separable units. The major challenges with the fleet of slow-speed integral machines are: limited flexibility and a large range in performance. In an attempt to increase flexibility, many operators are choosing to single-act cylinders, which are causing reduced reliability and integrity. While the best performing units in the fleet exhibit thermal efficiencies between 90% and 92%, the low performers are running down to 50% with the mean at about 80%. The major cause for this large disparity is due to installation losses in the pulsation control system. In the better performers, the losses are about evenly split between installation losses and valve losses. The major challenges for high-speed machines are: cylinder nozzle pulsations, mechanical vibrations due to cylinder stretch, short valve life, and low thermal performance. To shift nozzle pulsation to higher orders, nozzles are shortened, and to dampen the amplitudes, orifices are added. The shortened nozzles result in mechanical coupling with the cylinder, thereby, causing increased vibration due to the cylinder stretch mode. Valve life is even shorter than for slow speeds and can be on the order of a few months. The thermal efficiency is 10% to 15% lower than slow-speed equipment with the best performance in the 75% to 80% range. The goal of this advanced reciprocating compression program is to develop the technology for both high speed and low speed compression that will expand unit flexibility, increase thermal efficiency, and increase reliability and integrity

  4. Clean cast steel technology. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Bates, C.E.; Griffin, J.A.

    1998-06-01

    This report documents the results obtained from the Clean Cast Steel Technology Program financially supported by the DOE Metal Casting Competitiveness Research Program and industry. The primary objective of this program is to develop technology for delivering steel free of oxide macroinclusions to mold cavities. The overall objective is to improve the quality of cast steel by developing and demonstrating the technology for substantially reducing surface and sub-surface oxide inclusions. Two approaches are discussed here. A total of 23 castings were produced by submerge pouring along with sixty conventionally poured castings. The submerged poured castings contained, on average, 96% fewer observable surface inclusions (11.9 vs 0.4) compared to the conventionally poured cast parts. The variation in the population of surface inclusions also decreased by 88% from 5.5 to 0.7. The machinability of the casting was also improved by submerged pouring. The submerge poured castings required fewer cutting tool changes and less operator intervention during machining. Subsequent to these trials, the foundry has decided to purchase more shrouds for continued experimentation on other problem castings where submerge pouring is possible. An examination of melting and pouring practices in four foundries has been carried out. Three of the four foundries showed significant improvement in casting quality by manipulating the melting practice. These melting practice variables can be grouped into two separate categories. The first category is the pouring and filling practice. The second category concerns the concentration of oxidizable elements contained in the steel. Silicon, manganese, and aluminum concentrations were important factors in all four foundries. Clean heats can consistently be produced through improved melting practice and reducing exposure of the steel to atmospheric oxygen during pouring and filling.

  5. Technology Pathway Partnership Final Scientific Report

    Energy Technology Data Exchange (ETDEWEB)

    Hall, John C. Dr.; Godby, Larry A.

    2012-04-26

    This report covers the scientific progress and results made in the development of high efficiency multijunction solar cells and the light concentrating non-imaging optics for the commercial generation of renewable solar energy. During the contract period the efficiency of the multijunction solar cell was raised from 36.5% to 40% in commercially available fully qualified cells. In addition significant strides were made in automating production process for these cells in order to meet the costs required to compete with commercial electricity. Concurrent with the cells effort Boeing also developed a non imaging optical systems to raise the light intensity at the photovoltaic cell to the rage of 800 to 900 suns. Solar module efficiencies greater than 30% were consistently demonstrated. The technology and its manufacturing were maturated to a projected price of < $0.015 per kWh and demonstrated by automated assembly in a robotic factory with a throughput of 2 MWh/yr. The technology was demonstrated in a 100 kW power plant erected at California State University Northridge, CA.

  6. Early phase Technology Assessment of nanotechnology in oncology

    OpenAIRE

    Retèl, Valesca P; Hummel, Marjan J.M.; Harten, van, W.H.

    2008-01-01

    To perform early Technology Assessment (TA) of nanotechnology in oncology. The possibilities of nanotechnology for detection (imaging), diagnosis and treatment of cancer are subject of different research programs where major investments are concerned. As a range of bio- nanotechnologies is expected to enter the oncology field it is relevant to consider the various aspects involved in especially early TA. This article provides two cases of early assessment of (predecessors of) nanotechnologies...

  7. Assessing Elementary Pupils' Attitudes Toward Technology

    OpenAIRE

    Holter, Charlotte Ann

    2016-01-01

    Making all US citizens technologically literate necessitates investigation into how to achieve this literacy. The Standards for Technological Literacy: Content for the Study of Technology (STL) is intentional about ensuring technological literacy in all students. Instilling this knowledge in elementary students is an emerging field that requires assessment tools that conveys understanding into what student attitudes are about technology and technological concepts. Developing appropriate techn...

  8. Issues in health technology assessment

    International Nuclear Information System (INIS)

    Full text: In general, the main justification for the provision of health services is to improve the health of individuals and populations. Some experts focus on other goals for the health care systems, such as promoting health care innovation and increasing employment. Information on the efficacy of a diagnostic or therapeutic procedure has become more widely available during the last 25 years, both through increased research and increased availability of data based on, e.g. the Cochrane Collaboration and the Health Technology Assessment Database (INAHTA). At the same time, the most relevant information is often in proprietary hands, that is, in private organizations such as the manufacturing industry or in organizations that collect health information. The American Food and Drug Administration routinely assesses efficacy of devices and makes this information openly accessible. Unfortunately, the European Union focuses on trade issues, including innovation, and does not have a strong focus on public health. Competition for health care resources is a major concern even in segments of the population living in the richest countries. The problem of limited resources is, of course, much more pronounced in poor countries, in particular in the poorest countries. Although cost effectiveness of health care is very important conceptually, data are often not available. Cost effectiveness is often developed within the context of national needs and is very difficult to transfer to other jurisdictions. In addition, data on cost effectiveness are often not available to compare different options in health care. There is thus enormous scope for such studies in the future. Broader issues, such as health care organization and morals and ethics are also important. For example, is it ethical to promote advanced technology in poor countries that cannot provide even basic health care services? Is it ethical for researchers to overlook the basic needs of poor countries when working on

  9. NOVEL TECHNOLOGIES FOR GASEOUS CONTAMINANTS CONTROL; FINAL

    International Nuclear Information System (INIS)

    The overall objective of this project is to develop technologies for cleaning/conditioning the syngas from an integrated gasification combined cycle (IGCC) system to meet the tolerance limits for contaminants such as H(sub 2)S, COS, NH(sub 3), HCN, HCl, and alkali for fuel cell and chemical production applications. RTI's approach is to develop a modular system that (1) removes reduced sulfur species to sub-ppm levels using a hybrid process consisting of a polymer membrane and a regenerable ZnO-coated monolith or a mixed metal oxide sorbent; (2) removes hydrogen chloride vapors to sub-ppm levels using an inexpensive, high-surface area material; and (3) removes NH(sub 3) with acidic adsorbents. RTI is working with MEDAL, Inc., and North Carolina State University (NCSU) to develop polymer membrane technology for bulk removal of H(sub 2)S from syngas. These membranes are being engineered to remove the acid gas components (H(sub 2)S, CO(sub 2), NH(sub 3), and H(sub 2)O) from syngas by focusing on the ''solubility selectivity'' of the novel polymer compositions. The desirable components of the syngas (H(sub 2) and CO) are maintained at high-pressure conditions as a non-permeate stream while the impurities are transported across the membrane to the low pressure side. RTI tested commercially available and novel materials from MEDAL using a high-temperature, high-pressure (HTHP) permeation apparatus. H(sub 2)S/H(sub 2) selectivities and gt;30 were achieved, although there was a strong negative dependence with temperature. MEDAL believes that all the polymer compositions tested so far can be prepared as hollow fiber membrane modules using the existing manufacturing technology. For fuel cell and chemical applications, additional sulfur removal (beyond that achievable with the membranes) is required. To overcome limitations of conventional ZnO pellets, RTI is testing a monolith with a thin coating of high surface area zinc-oxide based materials. Alternatively, a regenerable

  10. Decision Gate Process for Assessment of a Technology Development Portfolio

    Science.gov (United States)

    Kohli, Rajiv; Fishman, Julianna; Hyatt, Mark

    2012-01-01

    The NASA Dust Management Project (DMP) was established to provide technologies (to TRL 6 development level) required to address adverse effects of lunar dust to humans and to exploration systems and equipment, which will reduce life cycle cost and risk, and will increase the probability of sustainable and successful lunar missions. The technology portfolio of DMP consisted of different categories of technologies whose final product is either a technology solution in itself, or one that contributes toward a dust mitigation strategy for a particular application. A Decision Gate Process (DGP) was developed to assess and validate the achievement and priority of the dust mitigation technologies as the technologies progress through the development cycle. The DGP was part of continuous technology assessment and was a critical element of DMP risk management. At the core of the process were technology-specific criteria developed to measure the success of each DMP technology in attaining the technology readiness levels assigned to each decision gate. The DGP accounts for both categories of technologies and qualifies the technology progression from technology development tasks to application areas. The process provided opportunities to validate performance, as well as to identify non-performance in time to adjust resources and direction. This paper describes the overall philosophy of the DGP and the methodology for implementation for DMP, and describes the method for defining the technology evaluation criteria. The process is illustrated by example of an application to a specific DMP technology.

  11. Building Information Modelling Incorporating Technology Based Assessment

    OpenAIRE

    Murphy, Maurice; Scott, Lloyd

    2011-01-01

    Building Information Modelling (BIM) is currently being developed as a virtual learning tool for construction and surveying students in the Dublin Institute of Technology. This advanced technology is also used to develop a technology based assessment practice for enhancing the learning environment of construction and surveying students. A theoretical design framework is presented in this paper, which combines advanced technology and assessment theory to create a virtual learning environment. ...

  12. New technology for future colliders. Final report

    International Nuclear Information System (INIS)

    This document presents an annual report on our long-term R and D grant for development of new technology for future colliders. The organizing theme of our development is to develop a compact high-field collider dipole, utilizing wind-and-react Nb3Sn coil fabrication, stress management, conductor optimization, bladder preload, and flux plate suppression of magnetization multipoles . The development trail for this new technology began over four years ago with the successful testing of TAMU12, a NbTi model in which we put to a first test many of the construction details of the high-field design. We have built TAMU2, a mirror-geometry dipole containing a single coil module of the 3-module set required for the 14 Tesla design. This first Nb3Sn model was built using ITER conductor which carries much less current than high-performance conductor but enables us to prove in practice our reaction bake and impregnation strategies with ''free'' superconductor. TAMU2 has been shipped to LBNL for testing. Work is beginning on the construction of TAMU3, which will contain two coil modules of the 14 Tesla design. TAMU3 has a design field of 13.5 Tesla, and will enable us to fully evaluate the issues of stress management that will be important to the full design. With the completion of TAMU2 and the construction of TAMU3 the Texas A and M group ''comes of age'' in the family of superconducting magnet R and D laboratories. We have completed the phase of developing core technologies and fixtures and entered the phase of building and testing a succession of TAMU3 model dipoles that each build incrementally upon a proven core design. TAMU3 provides a testbed in which we can build a succession of model dipoles in which each new model uses one new winding module coupled with one module from the previous model, and uses all of the same structural elements in successive models. This incremental development should enable us to keep to a minimum the time between the completion and testing of

  13. ESDRED Temporary Sealing Technology Final Technical Report

    International Nuclear Information System (INIS)

    The work in the ESDRED In te grated Project Module 4, Temporary Sealing (using low pH cement) Technology, consisted first of designing a low pH cement formulation and then of preparing several concrete designs suitable for the construction of sealing plugs and for rock support using shot crete techniques. Regarding sealing plugs, a short plug was constructed at Aspo in Sweden and it was very quickly loaded to failure i.e. slippage by applying water pressure to one face. A second, full scale plug was subsequently constructed at Grimsel test site in Switzerland. It was loaded using the swelling pressure created by bentonite blocks which were artificially hydrated. At time of writing the targeted pressure on the plug was not reached. As the saturation of the bentonite is taking longer than expected the partners involved agreed to continue with the saturation of the bentonite blocks and the related data monitoring beyond the ESDRED Project. The studies on low-pH shot crete for rock sup port were based on available recipes of low-pH concrete mixtures for use in a repository. Pilot and full scale tests were carried out in Sweden and in Switzerland. (Author) 5 refs

  14. Establishment of Health Technology Assessment in Iran

    Directory of Open Access Journals (Sweden)

    Shila Doaee

    2012-06-01

    Full Text Available Objective: Health Technology Assessment (HTA aims at informing healthcare policymakers, managers and practitioners of the "clinical consequences, but also the economic, ethical, and other social implications of the diffusion and use of a specific procedure or technique on medical practice". So considering the policy-oriented nature of HTA that calls for a close integration into the functioning and governance of health systems the present study focuses on executive processes and function of the HTA office of Iran.Materials and methods: Data of this review study were collected through documented sources and observations from 2007 to 2010.Results: Health Technology Assessment began its activities as a secretariat in the Deputy of Health in 2007 and it continues as a Health Technology Assessment Office at the Management of Health Technology Assessment, Standardization, and Tariff at the Deputy of curative affairs of MOHME in the beginning of 2010.14 Technology of modern medical equipment and 8 pharmaceutical medicine are assessed, Now many of measures for HTA establishment  such as cooperation National Institute of Health Research (NIHR, Holding scientific committee meetings, Establishing  the  Master's degree of  health technology assessment ,Building capacities for health technology assessment through education in major universities of the country.Conclusion: pay attention to health technology assessment, selection and application of proper technologies in the frameworks of policy-making and managerial strategies and make efforts to develop it with the support of the governmental in Iran is necessary.

  15. Technological advances in radiotherapy for esophageal cancer

    Institute of Scientific and Technical Information of China (English)

    Milan; Vosmik; Jiri; Petera; Igor; Sirak; Miroslav; Hodek; Petr; Paluska; Jiri; Dolezal; Marcela; Kopacova

    2010-01-01

    Radiotherapy with concurrent chemotherapy and surgery represent the main treatment modalities in esophageal cancer.The goal of modern radiotherapy approaches,based on recent technological advances,is to minimize post-treatment complications by improving the gross tumor volume definition (positron emission tomography-based planning),reducing interfraction motion (image-guided radiotherapy) and intrafraction motion (respiratory-gated radiotherapy),and by better dose delivery to the precisely defined planning ...

  16. 2013 Final Report: Integrated Science Assessment for Lead

    Science.gov (United States)

    lead_isa_cover.jpg" alt="Cover of the Integrated Science Assessment (ISA) for Lead" vspace = "5" hspace="5" align="right" border="1" /> EPA released the final report, Integrated Science Assessment (ISA) for Lead (...

  17. Use of mobile learning technology among final year medical students in Kenya

    OpenAIRE

    Masika, Moses Muia; Omondi, Gregory Barnabas; Natembeya, Dennis Simiyu; Mugane, Ephraim Mwatha; Bosire, Kefa Ogonyo; Kibwage, Isaac Ongubo

    2015-01-01

    Introduction Mobile phone penetration has increased exponentially over the last decade as has its application in nearly all spheres of life including health and medical education. This study aimed at assessing the use of mobile learning technology and its challenges among final year undergraduate students in the College of Health sciences, University of Nairobi. Methods This was a cross-sectional descriptive study conducted among final year undergraduate students at the University of Nairobi,...

  18. Life Cycle Assessment of Slurry Management Technologies

    DEFF Research Database (Denmark)

    Wesnæs, Marianne; Wenzel, Henrik; Petersen, Bjørn Molt

    This report contains the results of Life Cycle Assessments of two slurry management technologies - acidification and decentred incineration. The LCA foundation can be used by the contributing companies for evaluating the environmental sustainability of a specific technology from a holistic Life...... Cycle perspective. Through this the companies can evaluate the environmental benefits and disadvantages of introducing a specific technology for slurry management. From a societal perspective the results can contribute to a clarification of which slurry management technologies (or combination of...

  19. Health Technology Assessment and patient safety

    OpenAIRE

    Andrew Mulcahy; Tom Walley

    2005-01-01

    Health Technology Assessment (HTA) is a process used to evaluate the clinical effectiveness and costeffectiveness of health technologies by a systematic review of clinical, economic, and utilization research.

    Despite widespread investment in patient safety technologies in the U.K., U.S., and elsewhere, little HTA has been done to establish the clinical or cost-effectiveness of these technologies. The HTA and patient safety literature suggests there are four categori...

  20. Technological risks - assessment and management

    International Nuclear Information System (INIS)

    The technological reliability of products, equipment and processes plays an ever increasing role in political motivation - and not only with respect to environmental questions. Present day hazard potential, risk acceptance and the estimation of the consequences of technical risks are dealt with on the basis of the past history of technological risks. The mechanisms for coping with these risks and the unavoidable ethical implications are then considered. (orig.)

  1. Social Shaping in Danish Technology Assessment

    DEFF Research Database (Denmark)

    Hansen, Anne Grethe; Clausen, Christian

    2003-01-01

    The term ‘social shaping of technology’ has been used broadly as a response to techno-economic deterministic understandings of the relations between technology and society. Social shaping has brought together analysts from different backgrounds who share a common interest in the role of social and...... these projects contributed to new insights into the processes of technological change and thus to policy formulation. The social shaping perspective and technology assessment experiences are suggested as important guides to future technology strategies....... political action for technology change. The authors of this article suggest that the social shaping perspective draws on lessons from technology assessments of earlier decades, lessons about the role of technology debate, participation and democratic control. We suggest that these are important for...

  2. Advanced Air Transportation Technologies Project, Final Document Collection

    Science.gov (United States)

    Mogford, Richard H.; Wold, Sheryl (Editor)

    2008-01-01

    This CD ROM contains a compilation of the final documents of the Advanced Air Transportation Technologies (AAIT) project, which was an eight-year (1996 to 2004), $400M project managed by the Airspace Systems Program office, which was part of the Aeronautics Research Mission Directorate at NASA Headquarters. AAIT focused on developing advanced automation tools and air traffic management concepts that would help improve the efficiency of the National Airspace System, while maintaining or enhancing safety. The documents contained in the CD are final reports on AAIT tasks that serve to document the project's accomplishments over its eight-year term. Documents include information on: Advanced Air Transportation Technologies, Autonomous Operations Planner, Collaborative Arrival Planner, Distributed Air/Ground Traffic Management Concept Elements 5, 6, & 11, Direct-To, Direct-To Technology Transfer, Expedite Departure Path, En Route Data Exchange, Final Approach Spacing Tool - (Active and Passive), Multi-Center Traffic Management Advisor, Multi Center Traffic Management Advisor Technology Transfer, Surface Movement Advisor, Surface Management System, Surface Management System Technology Transfer and Traffic Flow Management Research & Development.

  3. River Protection Project information systems assessment; FINAL

    International Nuclear Information System (INIS)

    The Information Systems Assessment Report documents the results from assessing the Project Hanford Management Contract (PHMC) Hanford Data Integrator 2000 (HANDI 2000) system, Business Management System (BMS) and Work Management System phases (WMS), with respect to the System Engineering Capability Assessment Model (CAM). The assessment was performed in accordance with the expectations stated in the fiscal year (FY) 1999 Performance Agreement 7.1.1, item (2) which reads, ''Provide an assessment report on the selected Integrated Information System by July 31, 1999.'' This report assesses the BMS and WMS as implemented and planned for the River Protection Project (RPP). The systems implementation is being performed under the PHMC HANDI 2000 information system project. The project began in FY 1998 with the BMS, proceeded in FY 1999 with the Master Equipment List portion of the WMS, and will continue the WMS implementation as funding provides. This report constitutes an interim quality assessment providing information necessary for planning RPP's information systems activities. To avoid confusion, HANDI 2000 will be used when referring to the entire system, encompassing both the BMS and WMS. A graphical depiction of the system is shown in Figure 2-1 of this report

  4. Economic Feasibility and Market Readiness of Solar Technologies. Draft Final Report. Volume I.

    Energy Technology Data Exchange (ETDEWEB)

    Flaim, Silvio J.; Buchanan, Deborah L.; Christmas, Susan; Fellhauer, Cheryl; Glenn, Barbara; Ketels, Peter A.; Levary, Arnon; Mourning, Pete; Steggerda, Paul; Trivedi, Harit; Witholder, Robert E.

    1978-09-01

    Systems descriptions, costs, technical and market readiness assessments are reported for ten solar technologies: solar heating and cooling of buildings (SHACOB), passive, agricultural and industrial process heat (A/IPH), biomass, ocean thermal (OTEC), wind (WECS), solar thermal electric, photovoltaics, satellite power station (SPS), and solar total energy systems (STES). Study objectives, scope, and methods. are presented. of Joint Task The cost and market analyses portion 5213/6103 will be used to make commercialization assessments in the conclusions of. the final report.

  5. Civil Engineering Technology Needs Assessment.

    Science.gov (United States)

    Oakland Community Coll., Farmington, MI. Office of Institutional Planning and Analysis.

    In 1991, a study was conducted by Oakland Community College (OCC) to evaluate the need for a proposed Civil Engineering Technology program. An initial examination of the literature focused on industry needs and the job market for civil engineering technicians. In order to gather information on local area employers' hiring practices and needs, a…

  6. Technology assessment of RDX production

    Energy Technology Data Exchange (ETDEWEB)

    Coburn, M.D. [New Mexico Inst. of Mining and Technology, Socorro, NM (United States)

    1995-04-01

    The known processes for producing RDX were assessed with the goal of identifying the process that would generate the least waste and pollution. It was concluded that the Bachman process employed at Holston AAP is the most economical process for producing RDX and that it probably produces less waste than any other process. It was generally agreed that the entire Holston operation is a very clean one that complies with all federal and state emission standards. In addition, a number of opportunities in which Holston could reduce their wastes were identified. Preliminary assessments of waste and pollution profiles for alternate materials, with emphasis on dual-use materials, were performed.

  7. The Clinical Proteomic Technologies for Cancer | Antibody Portal

    Science.gov (United States)

    An objective of the Reagents and Resources component of NCI's Clinical Proteomic Technologies for Cancer Initiative is to generate highly characterized monoclonal antibodies to human proteins associated with cancer.

  8. The Clinical Proteomic Technologies for Cancer | Antibody Scientific Committee

    Science.gov (United States)

    An objective of the Reagents and Resources component of NCI's Clinical Proteomic Technologies for Cancer Initiative is to generate highly characterized monoclonal antibodies to human proteins associated with cancer.

  9. The Clinical Proteomic Technologies for Cancer | Characterization Process

    Science.gov (United States)

    An objective of the Reagents and Resources component of NCI's Clinical Proteomic Technologies for Cancer Initiative is to generate highly characterized monoclonal antibodies to human proteins associated with cancer.

  10. The Clinical Proteomic Technologies for Cancer | Reagent Opportunities

    Science.gov (United States)

    An objective of the Reagents and Resources component of NCI's Clinical Proteomic Technologies for Cancer Initiative is to generate highly characterized monoclonal antibodies to human proteins associated with cancer.

  11. Assessing medical technologies in development - A new paradigm of medical technology assessment

    NARCIS (Netherlands)

    Hummel, MJM; van Rossum, W; Verkerke, GJ; Rakhorst, G

    2000-01-01

    Objective: Our study aims to provide a practical contribution to the field of medical technology assessment within a new paradigm. This paradigm indicates the need for more comprehensive technology assessments in the development stage of a new technology. Method: We introduce a method, based on Saat

  12. Seeing Technology Assessment with New Eyes

    OpenAIRE

    Krom, André; Ganzevles, Jurgen; Nentwich, Michael; van Est, Rinie

    2015-01-01

    In: Klüver/Nielsen/Jørgensen (Eds.), 2015, Policy-Oriented Technology Assessment Across Europe. Expanding Capacities; London: Palgrave Pivot; 18-36.Van Est et al. present a 'relational' model for analysing technology assessment (TA) institutions. Expanding on metaphor of TA as a bridge between science, society and policy, the authors describe how such bridges are established in terms of network relations. European TA institutions in various ways link parliaments and governments with civil soc...

  13. Minidoka Dam Wildlife Impact Assessment: Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Robert C.; Meuleman, G. Allyn

    1989-03-01

    A wildlife impact assessment has been developed for the US Bureau of Reclamation's Minidoka Dam and Reservoir in south central Idaho. This assessment was conducted to fulfill requirements of the Fish and Wildlife Program. Specific objectives of this study included the following: select target wildlife species, and identify their current status and management goals; estimate the net effects on target wildlife species resulting from hydroelectric development and operation; recommend protection, mitigation, and enhancement goals for target wildlife species affected by hydroelectric development and operation; and consult and coordinate impact assessment activities with the Northwest Power Planning Council, Bonneville Power Administration, US Bureau of Reclamation, Bureau of Land Management, Shoshone-Bannock Tribes, US Fish and Wildlife Service, Pacific Northwest Utilities Conference Committee, and other entities expressing interest in the project. 62 refs., 2 figs., 11 tabs.

  14. Cancer Risk Assessment for the Primary Care Physician

    OpenAIRE

    Korde, Larissa A; Gadalla, Shahinaz M.

    2009-01-01

    Cancer is the second leading cause of death in the United States. Cancer risk assessment can be divided into two major categories: assessment of familial or genetic risk and assessment of environmental factors that may be causally related to cancer. Identification of individuals with a suspected heritable cancer syndrome can lead to additional evaluation and to interventions that can substantially decrease cancer risk. Special attention should also be paid to potentially modifiable cancer ris...

  15. Strategic technology assessment of organic photovoltaics

    OpenAIRE

    Sebastien, Lizin

    2014-01-01

    This dissertation aims at answering the question: “Are organic photovoltaics in its current state a way to pursue for public institutes targeting technology transfer?”. To this end, a strategic technology assessment approach has been applied to gain insights from the supply side (chapter 2), the social desirability (chapter 3), and the demand side of technology creation (chapters 4 – 5). This dissertation, for the first time, combines insights from these three angles to provide an answer on o...

  16. Small Wind Turbine Technology Assessment

    International Nuclear Information System (INIS)

    The result of the study carried out under the scope of the ATYCA project Test Plant of Wind Systems for Isolated Applications, about the state of art of the small wind turbine technology (wind turbines with swept area smaller than 40 m2) is presented. The study analyzes the collected information on 60 models of wind turbines from 23 manufacturers in the worldwide market. Data from Chinese manufacturers, that have a large participation in the total number of small wind turbines in operation, are not included, due to the unavailability of the technical information. (Author) 15 refs

  17. An environmental assessment system for environmental technologies

    DEFF Research Database (Denmark)

    Clavreul, Julie; Baumeister, Hubert; Christensen, Thomas Højlund;

    2014-01-01

    A new model for the environmental assessment of environmental technologies, EASETECH, has been developed. The primary aim of EASETECH is to perform life-cycle assessment (LCA) of complex systems handling heterogeneous material flows. The objectives of this paper are to describe the EASETECH...

  18. Assessment and Learning Technologies: An Overview

    Science.gov (United States)

    Farrell, Treasa; Rushby, Nick

    2016-01-01

    Assessment pervades the learning process. This paper provides an overview of the application of technology to support and enhance diagnostic, formative and summative assessment. The focus is on examining how it can replace what already exists, improve the functionality, catalyse a redesign of the process and in some circumstances, make possible…

  19. Final environmental assessment: Sacramento Energy Service Center

    Energy Technology Data Exchange (ETDEWEB)

    1994-03-01

    The Sacramento Area Office (SAO) of the Western Area Power Administration (Western) needs to increase the security of operations, to eliminate overcrowding at the current leased location of the existing facilities, to provide for future growth, to improve efficiency, and to reduce operating costs. The proposed action is to construct an approximate 40,000-square foot building and adjacent parking lot with a Solar Powered Electric Vehicle Charging Station installed to promote use of energy efficient transportation. As funding becomes available and technology develops, additional innovative energy-efficient measures will be incorporated into the building. For example the proposed construction of the Solar Powered Electric Vehicle Charging.

  20. Information Technology Assessment Study: Full Report

    Science.gov (United States)

    Peterson, John (Editor)

    2002-01-01

    A team was formed to assess NASA Office of Space Science (OSS) information technology research and development activities. These activities were reviewed for their relevance to OSS missions, for their potential for using products better supplied by industry or other government agencies, and for recommending an information technology (IT) infusion strategy for appropriate products for OSS missions. Assessment scope and methodology are presented. IT needs and interests for future OSS missions and current NASA IT research and development (R&D) are discussed. Non-NASA participants provide overviews of some of their IT R&D programs. Implementation and infusion issues and the findings and recommendations of the assessment team are presented.

  1. Health technology assessment. Evaluation of biomedical innovative technologies.

    Science.gov (United States)

    Turchetti, Giuseppe; Spadoni, Enza; Geisler, Eliezer Elie

    2010-01-01

    This article describes health technology assessment (HTA) as an evaluation tool that applies systematic methods of inquiry to the generation and use of health technologies and new products. The focus of this article is on the contributions of HTA to the management of the new product development effort in the biomedical organization. Critical success factors (CSFs) are listed, and their role in assessing success is defined and explained. One of the conclusions of this article is that HTA is a powerful tool for managers in the biomedical sector, allowing them to better manage their innovation effort in their continuing struggle for competitiveness and survival. PMID:20659860

  2. Final Environmental Assessment Ohio River Islands National Wildlife Refuge Proposal

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — In this Final Environmental Assessment, the United States Fish and Wildlife Service describes various alternatives that could provide long-term protection to the...

  3. 78 FR 46905 - Tobacco Transition Program; Final Assessment Procedures

    Science.gov (United States)

    2013-08-02

    ... information about the final quarterly assessments for the Tobacco Transition Program (TTP). Through the Tobacco Transition Payment Program (TTPP), which is part of the TTP, eligible former tobacco quota holders..., 2014. Also, as specified in the TTP regulations, the final two calendar quarterly payments are both...

  4. NANA Geothermal Assessment Program Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Jay Hermanson

    2010-06-22

    In 2008, NANA Regional Corporation (NRC) assessed geothermal energy potential in the NANA region for both heat and/or electricity production. The Geothermal Assessment Project (GAP) was a systematic process that looked at community resources and the community's capacity and desire to develop these resources. In October 2007, the US Department of Energy's Tribal Energy Program awarded grant DE-FG36-07GO17075 to NRC for the GAP studies. Two moderately remote sites in the NANA region were judged to have the most potential for geothermal development: (1) Granite Mountain, about 40 miles south of Buckland, and (2) the Division Hot Springs area in the Purcell Mountains, about 40 miles south of Shungnak and Kobuk. Data were collected on-site at Granite Mountain Hot Springs in September 2009, and at Division Hot Springs in April 2010. Although both target geothermal areas could be further investigated with a variety of exploration techniques such as a remote sensing study, a soil geochemical study, or ground-based geophysical surveys, it was recommended that on-site or direct heat use development options are more attractive at this time, rather than investigations aimed more at electric power generation.

  5. 77 FR 15121 - Final Land Protection Plan and Final Environmental Assessment for Everglades Headwaters National...

    Science.gov (United States)

    2012-03-14

    ... September 8, 2011, we published a Federal Register notice (76 FR 55699) announcing the proposed... published a Federal Register notice (76 FR 66321) announcing the extension of the comment deadline to... Fish and Wildlife Service Final Land Protection Plan and Final Environmental Assessment for...

  6. Wabash River Coal Gasification Repowering Project: A DOE Assessment; FINAL

    International Nuclear Information System (INIS)

    The goal of the U.S. Department of Energy (DOE) Clean Coal Technology Program (CCT) is to furnish the energy marketplace with a number of advanced, more efficient, and environmentally responsible coal utilization technologies through demonstration projects. These projects seek to establish the commercial feasibility of the most promising advanced coal technologies that have developed beyond the proof-of-concept stage. This document serves as a DOE post-project assessment (PPA) of a project selected in CCT Round IV, the Wabash River Coal Gasification Repowering (WRCGR) Project, as described in a Report to Congress (U.S. Department of Energy 1992). Repowering consists of replacing an existing coal-fired boiler with one or more clean coal technologies to achieve significantly improved environmental performance. The desire to demonstrate utility repowering with a two-stage, pressurized, oxygen-blown, entrained-flow, integrated gasification combined-cycle (IGCC) system prompted Destec Energy, Inc., and PSI Energy, Inc., to form a joint venture and submit a proposal for this project. In July 1992, the Wabash River Coal Gasification Repowering Project Joint Venture (WRCGRPJV, the Participant) entered into a cooperative agreement with DOE to conduct this project. The project was sited at PSI Energy's Wabash River Generating Station, located in West Terre Haute, Indiana. The purpose of this CCT project was to demonstrate IGCC repowering using a Destec gasifier and to assess long-term reliability, availability, and maintainability of the system at a fully commercial scale. DOE provided 50 percent of the total project funding (for capital and operating costs during the demonstration period) of$438 million. Construction for the demonstration project was started in July 1993. Pre-operational tests were initiated in August 1995, and construction was completed in November 1995. Commercial operation began in November 1995, and the demonstration period was completed in December

  7. Complementary Safety Margin Assessment. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-10-15

    On March 11, 2011, a large part of the Japanese eastern coastal area was devastated by an earthquake, followed by an immense tsunami. As a result, thousands of people were killed, injured or made homeless. In the days that followed, the situation was further complicated because of the failing nuclear reactors on the Fukushima coast. The local environment suffered from radioactive releases, requiring evacuation zones, and generating international concerns about nuclear safety. In the wake of this disaster the European Union decided to assess safety on all operating nuclear reactors in its member states. This safety evaluation initiated by the European Union focusses on extreme natural hazards, beyond the standard safety evaluations which regularly have to be performed to demonstrate the safety of a nuclear power plant. Consequences of these extreme hazards for the Borssele NPP have been evaluated based on available safety analyses, supplemented by engineering judgement. In this way, the robustness of the existing plant has been assessed and possible measures to further increase the safety margins have been identified. This document presents the results of the Complementary Safety margin Assessment (CSA) performed for the NPP Borssele. The distinct difference between this report and former risk analysis reports in general and the existing Safety Report of the NPP Borssele is that the maximum resistance of the plant against redefined and more challenging events has been investigated, whereas traditionally the plant design is investigated against certain events that are determined on a historical basis. This different approach requires different analyses and studies, which in turn presents new insights into the robustness of the plant. This document has been prepared in the short time period between June 1 and October 31, 2011. If more time had been granted for this study, some of the subjects could have been pursued in greater depth. The EPZ project team has been

  8. Klickitat Cogeneration Project : Final Environmental Assessment.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration; Klickitat Energy Partners

    1994-09-01

    To meet BPA`s contractual obligation to supply electrical power to its customers, BPA proposes to acquire power generated by Klickitat Cogeneration Project. BPA has prepared an environmental assessment evaluating the proposed project. Based on the EA analysis, BPA`s proposed action is not a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act of 1969 for the following reasons: (1)it will not have a significant impact land use, upland vegetation, wetlands, water quality, geology, soils, public health and safety, visual quality, historical and cultural resources, recreation and socioeconomics, and (2) impacts to fisheries, wildlife resources, air quality, and noise will be temporary, minor, or sufficiently offset by mitigation. Therefore, the preparation of an environmental impact statement is not required and BPA is issuing this FONSI (Finding of No Significant Impact).

  9. Boise geothermal injection well: Final environmental assessment

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    The City of Boise, Idaho, an Idaho Municipal Corporation, is proposing to construct a well with which to inject spent geothermal water from its hot water heating system back into the geothermal aquifer. Because of a cooperative agreement between the City and the US Department of Energy to design and construct the proposed well, compliance to the National Environmental Policy Act (NEPA) is required. Therefore, this Environmental Assessment (EA) represents the analysis of the proposed project required under NEPA. The intent of this EA is to: (1) briefly describe historical uses of the Boise Geothermal Aquifer; (2) discuss the underlying reason for the proposed action; (3) describe alternatives considered, including the No Action Alternative and the Preferred Alternative; and (4) present potential environmental impacts of the proposed action and the analysis of those impacts as they apply to the respective alternatives.

  10. Klickitat Cogeneration Project: Final environmental assessment

    International Nuclear Information System (INIS)

    To meet BPA's contractual obligation to supply electrical power to its customers, BPA proposes to acquire power generated by Klickitat Cogeneration Project. BPA has prepared an environmental assessment evaluating the proposed project. Based on the EA analysis, BPA's proposed action is not a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act of 1969 for the following reasons: (1)it will not have a significant impact land use, upland vegetation, wetlands, water quality, geology, soils, public health and safety, visual quality, historical and cultural resources, recreation and socioeconomics, and (2) impacts to fisheries, wildlife resources, air quality, and noise will be temporary, minor, or sufficiently offset by mitigation. Therefore, the preparation of an environmental impact statement is not required and BPA is issuing this FONSI (Finding of No Significant Impact)

  11. Boise geothermal injection well: Final environmental assessment

    International Nuclear Information System (INIS)

    The City of Boise, Idaho, an Idaho Municipal Corporation, is proposing to construct a well with which to inject spent geothermal water from its hot water heating system back into the geothermal aquifer. Because of a cooperative agreement between the City and the US Department of Energy to design and construct the proposed well, compliance to the National Environmental Policy Act (NEPA) is required. Therefore, this Environmental Assessment (EA) represents the analysis of the proposed project required under NEPA. The intent of this EA is to: (1) briefly describe historical uses of the Boise Geothermal Aquifer; (2) discuss the underlying reason for the proposed action; (3) describe alternatives considered, including the No Action Alternative and the Preferred Alternative; and (4) present potential environmental impacts of the proposed action and the analysis of those impacts as they apply to the respective alternatives

  12. Final rapid reactivation project environmental assessment

    International Nuclear Information System (INIS)

    The US Department of Energy (DOE) has prepared an environmental assessment (EA) for the Rapid Reactivation Project at Sandia National Laboratories, New Mexico. The EA analyzes the potential effects of a proposal to increase production of neutron generators from the current capability of 600 units per year up to 2,000 units per year. The project would use existing buildings and infrastructure to the maximum extent possible to meet the additional production needs. The increased production levels would necessitate modifications and additions involving a total area of approximately 26,290 gross square feet at Sandia National Laboratories, New Mexico, Technical Area 1. Additional production equipment would be procured and installed. The no-action alternative would be to continue production activities at the current capability of 600 units per year. The EA analyzes effects on health, safety, and air quality, resulting from construction and operation and associated cumulative effects. A detailed description of the proposed action and its environmental consequences is presented in the EA

  13. NANA Wind Resource Assessment Program Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Jay Hermanson

    2010-09-23

    NANA Regional Corporation (NRC) of northwest Alaska is located in an area with abundant wind energy resources. In 2007, NRC was awarded grant DE-FG36-07GO17076 by the US Department of Energy's Tribal Energy Program for funding a Wind Resource Assessment Project (WRAP) for the NANA region. The NANA region, including Kotzebue Electric Association (KEA) and Alaska Village Electric Cooperative (AVEC) have been national leaders at developing, designing, building, and operating wind-diesel hybrid systems in Kotzebue (starting in 1996) and Selawik (2002). Promising sites for the development of new wind energy projects in the region have been identified by the WRAP, including Buckland, Deering, and the Kivalina/Red Dog Mine Port Area. Ambler, Shungnak, Kobuk, Kiana, Noorvik & Noatak were determined to have poor wind resources at sites in or very near each community. However, all five of these communities may have better wind resources atop hills or at sites with slightly higher elevations several miles away.

  14. 31 CFR 27.7 - Final Notice of Assessment.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Final Notice of Assessment. 27.7 Section 27.7 Money and Finance: Treasury Office of the Secretary of the Treasury CIVIL PENALTY ASSESSMENT... consideration all available information in the administrative record on the matter, including all...

  15. Assessing Students' Skills in Science & Technology

    OpenAIRE

    Orpwood, G

    2006-01-01

    This seminar is co-organised by the Centre for Information Technology in Education (CITE) and The Office of Research, Faculty of Education, HKU. The seminar will describe work in the Canadian province of Ontario to assess students skills in science and technology through a systematically constructed series of performance tasks. In addition, sets of "exemplars" of student performance were developed and are aviable in an on-line multi-media archive that will be shared with participants.

  16. Health-Care Technology Assessment in Radiology

    Directory of Open Access Journals (Sweden)

    Arash Deljou

    2010-05-01

    Full Text Available Health-care service provision and procurement is increasingly subject to policy decisions, managed more than ever before. Becoming more international, collaboration is increasing as the health professions, research and industry all work across borders. Differing health-care systems across the countries result from national and regional policy developments and priorities."nIn health-care, all interventions and procedures are basically technologies-including radiology and sur-gery, and technology assessment is mandatory to meet the national and professional goals in this sec-tor. "nHealth-care technology assessment (HTA is a systematic, broad-ranging evaluation of the implications of using technologies within a particular health-care system. Structured and evidence-based input are its aim for policymaking in order to inform the formulation of safe and effective health policies that are patient-focused and seek to achieve the best value in all health-care sectors, more specifically in the radiology department. The following headlines are the topics in our study:"n•Decisions Related to Health Technologies"n•Appraisal Entities and Corresponding As-sessment Units"n•Assessment, Appraisal and Decision-Making Institutions"n•HTA Agencies and Units in Radiology"n•Model of a Policy Process in Radiology"n•Factors that Influence Radiology Policy-Making"n•HTA Process"n•Different Levels of Health-Care Technolo-gies/Intervention

  17. Final report: U.S. competitive position in automotive technologies

    Energy Technology Data Exchange (ETDEWEB)

    Albert, Michael B.; Cheney, Margaret; Thomas, Patrick; Kroll, Peter

    2002-09-30

    Patent data are presented and analyzed to assess the U.S. competitive position in eleven advanced automotive technology categories, including automotive fuel cells, hydrogen storage, advanced batteries, hybrid electric vehicles and others. Inventive activity in most of the technologies is found to be growing at a rapid pace, particularly in advanced batteries, automotive fuel cells and ultracapacitors. The U.S. is the clear leader in automotive fuel cells, on-board hydrogen storage and light weight materials. Japan leads in advanced batteries, hybrid electric vehicles, ultracapacitors, and appears to be close to overtaking the U.S. in other areas of power electronics.

  18. Independent Assessment of Technology Characterizations to Support the Biomass Program Annual State-of-Technology Assessments

    Energy Technology Data Exchange (ETDEWEB)

    Yeh, B.

    2011-03-01

    This report discusses an investigation that addressed two thermochemical conversion pathways for the production of liquid fuels and addressed the steps to the process, the technology providers, a method for determining the state of technology and a tool to continuously assess the state of technology. This report summarizes the findings of the investigation as well as recommendations for improvements for future studies.

  19. Information Technology Assessment Study: Executive Summary

    Science.gov (United States)

    Peterson, John (Editor)

    2002-01-01

    A team was formed to assess NASA Office of Space Science (OSS) information technology research and development activities. These activities were reviewed for their relevance to OSS missions, for their potential for using products better supplied by industry or other government agencies, and for recommending an IT infusion strategy for appropriate products for OSS missions. Assessment scope and methodology and the findings and recommendations of OSS IT users and providers are presented.

  20. An environmental assessment system for environmental technologies

    OpenAIRE

    Clavreul, Julie; Baumeister, Hubert; Christensen, Thomas Højlund; Damgaard, Anders

    2014-01-01

    A new model for the environmental assessment of environmental technologies, EASETECH, has been developed. The primary aim of EASETECH is to perform life-cycle assessment (LCA) of complex systems handling heterogeneous material flows. The objectives of this paper are to describe the EASETECH framework and the calculation structure. The main novelties compared to other LCA software are as follows. First, the focus is put on material flow modelling, as each flow is characterised as a mix of mate...

  1. Sustainability assessment of advanced wastewater treatment technologies

    DEFF Research Database (Denmark)

    Høibye, Linda; Clauson-Kaas, Jes; Wenzel, Henrik;

    2008-01-01

    As a consequence of the EU Water Framework Directive more focus is now on discharges of hazardous substances from wastewater treatment plants and sewers. Thus, many municipalities in Denmark may have to adopt to future advanced treatment technologies. This paper describes a holistic assessment...... with advanced oxidation. The technical assessment is based on 12 hazardous substances comprising heavy metals, organic pollutants, endocrine disruptors as well as pathogenic microorganisms. The environmental assessment is performed by life cycle assessment (LCA) comprising 9 of the specific hazardous substances...... of sustainability, sand filtration is the most advantageous method based on the technical and environmental assessment due to the low energy consumption and high efficiency with regards to removal of heavy metals. Key words | advanced wastewater treatment, life cycle assessment, MBR, ozone treatment, sand...

  2. Possible future environmental issues for fossil fuel technologies. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Attaway, L.D.

    1979-07-01

    The work reported here was carried out for the Department of Energy's Office of Fossil Energy to identify and assess 15 to 20 major environmental issues likely to affect the implementation of fossil energy technologies between 1985 and 2000. The energy technologies specifically addressed are: oil recovery and processing; gas recovery and processing; coal liquefaction; coal gasification (surface); in situ coal gasification; direct coal combustion; advanced power systems; magnetohydrodynamics; surface oil shale retorting; and true and modified in situ oil shale retorting. Environmental analysis of these technologies included, in addition to the main processing steps, the complete fuel cycle from resource extraction to end use. The 16 environmental issues identified as those most likely for future regulatory actions and the main features of, and the possible regulatory actions associated with, each are as follows: disposal of solid waste from coal conversion and combustion technologies; water consumption by coal and oil shale conversion technologies; siting of coal conversion facilities; the carbon dioxide greenhouse effect; emission of polycyclic organic matter (POM); impacts of outer continental shelf (OCS) oil development; emission of trace elements; groundwater contamination; liquefied natural gas (LNG), safety and environmental factors; underground coal mining - health and safety; fugitive emissions from coal gasification and liquefaction - health and safety; boomtown effects; emission of fine particulates from coal, oil and oil shale technologies; emission of radioactivity from the mining and conversion of coal; emission of nitrogn oxides; and land disturbance from surface mining. (LTN)

  3. 77 FR 11554 - Final Decision on Withdrawal of Breast Cancer Indication for AVASTIN (Bevacizumab) Following...

    Science.gov (United States)

    2012-02-27

    ... HUMAN SERVICES Food and Drug Administration Final Decision on Withdrawal of Breast Cancer Indication for... final decision withdrawing approval of the breast cancer indication for AVASTIN (Bevacizumab). The... proposal to withdraw the approval. DATES: Withdrawal of AVASTIN's breast cancer indication was...

  4. Economic assessment of advanced flue gas desulfurization processes. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Bierman, G. R.; May, E. H.; Mirabelli, R. E.; Pow, C. N.; Scardino, C.; Wan, E. I.

    1981-09-01

    This report presents the results of a project sponsored by the Morgantown Energy Technology Center (METC). The purpose of the study was to perform an economic and market assessment of advanced flue gas desulfurization (FGD) processes for application to coal-fired electric utility plants. The time period considered in the study is 1981 through 1990, and costs are reported in 1980 dollars. The task was divided into the following four subtasks: (1) determine the factors affecting FGD cost evaluations; (2) select FGD processes to be cost-analyzed; (3) define the future electric utility FGD system market; and (4) perform cost analyses for the selected FGD processes. The study was initiated in September 1979, and separate reports were prepared for the first two subtasks. The results of the latter two subtasks appear only in this final reprot, since the end-date of those subtasks coincided with the end-date of the overall task. The Subtask 1 report, Criteria and Methods for Performing FGD Cost Evaluations, was completed in October 1980. A slightly modified and condensed version of that report appears as appendix B to this report. The Subtask 2 report, FGD Candidate Process Selection, was completed in January 1981, and the principal outputs of that subtask appear in Appendices C and D to this report.

  5. Real Time Technology Application Demonstration Project Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Volpe, John [Univ of KY, Center for Applied Energy Research, Kentucky Research Consortium for Energy and Environment; Hampson, Steve [Univ of KY, Center for Applied Energy Research, Kentucky Research Consortium for Energy and Environment; Johnson, Robert L [Argonne National Lab, Environmental Science Div.

    2008-09-01

    The work and results described in this final report pertain to the demonstration of real-time characterization technologies applied to potentially contaminated surface soils in and around Area of Concern (AOC) 492 at the Paducah Gaseous Diffusion Plant (PGDP). The work was conducted under the auspices of Kentucky Research Consortium for Energy and Environment (KRCEE). KRCEE was created to support the Department of Energy's (DOE) efforts to complete the expeditious and economically viable environmental restoration of the Paducah Gaseous Diffusion Plant (PGDP), the Western Kentucky Wildlife Management Area (WKWMA), and surrounding areas.

  6. Technology and assessment of neutron absorbing materials

    International Nuclear Information System (INIS)

    The present review assesses more recent developments in the technology and application of those absorber materials which are considered to be established or to have shown potential in reactor control. Emphasis is placed on physical, chemical and metallurgical properties and upon irradiation behaviour. (author)

  7. Expanding the applicability of Heallth Technology Assessments

    DEFF Research Database (Denmark)

    Draborg, Eva; Hansen, Helle Ploug

    2012-01-01

    The objective of the presentation is to expand the foundations of input into policy decision making relying on health technology assessments (HTA). HTAs are primarily based on systematic reviews (SR) and thereby mostly on randomized controlled trials (RCT). RCTs can be distinguished on a continuu...

  8. Biomass Gasification Technology Assessment: Consolidated Report

    Energy Technology Data Exchange (ETDEWEB)

    Worley, M.; Yale, J.

    2012-11-01

    Harris Group Inc. (HGI) was commissioned by the National Renewable Energy Laboratory to assess gasification and tar reforming technologies. Specifically, the assessments focused on gasification and tar reforming technologies that are capable of producing a syngas suitable for further treatment and conversion to liquid fuels. HGI gathered sufficient information to analyze three gasification and tar reforming systems. This report summarizes the equipment, general arrangement of the equipment, operating characteristics, and operating severity for each technology. The order of magnitude capital cost estimates are supported by a basis-of-estimate write-up, which is also included in this report. The report also includes Microsoft Excel workbook models, which can be used to design and price the systems. The models can be used to analyze various operating capacities and pressures. Each model produces a material balance, equipment list, capital cost estimate, equipment drawings and preliminary general arrangement drawings. Example outputs of each model are included in the Appendices.

  9. Awareness, Interest, and Preferences of Primary Care Providers in Using Point-of-Care Cancer Screening Technology

    OpenAIRE

    Kim, Chloe S.; Vanture, Sarah; Cho, Margaret; Klapperich, Catherine M.; Wang, Catharine; Huang, Franklin W.

    2016-01-01

    Well-developed point-of-care (POC) cancer screening tools have the potential to provide better cancer care to patients in both developed and developing countries. However, new medical technology will not be adopted by medical providers unless it addresses a population’s existing needs and end-users’ preferences. The goals of our study were to assess primary care providers’ level of awareness, interest, and preferences in using POC cancer screening technology in their practice and to provide g...

  10. Sustainability assessment of advanced wastewater treatment technologies

    DEFF Research Database (Denmark)

    Høibye, Linda; Clauson-Kaas, Jes; Wenzel, Henrik;

    2007-01-01

    As a consequence of the EU Water Framwork Directive, more focus is now on discharges of hazardous substances from wastewater treatment plants and sewers. Thus, many municipalities in Denmark may have to adopt to future advenced treatment technologies. This paper describes a holistic assessment...... with advanced oxidation. The technical assessment is based on 12 hazardous substances comprising heavy metals, organic pollutants, endocrine disruptors as well as pathogenic microorganisms. The environmental assessment is performed by life cycle assessment (LCA) comprising 9 of the specific hazardous substances...... of sustainability, sand filtration is the most advantageous method based on the technical and environmental assessment due to the low energy consumption and high efficiency with regard to the removal of heavy metals....

  11. Technology Assessment and Roadmap for the Emergency Radiation Dose Assessment Program

    International Nuclear Information System (INIS)

    A Joint Interagency Working Group (JIWG) under the auspices of the Department of Homeland Security Office of Research and Development conducted a technology assessment of emergency radiological dose assessment capabilities as part of the overall need for rapid emergency medical response in the event of a radiological terrorist event in the United States. The goal of the evaluation is to identify gaps and recommend general research and development needs to better prepare the Country for mitigating the effects of such an event. Given the capabilities and roles for responding to a radiological event extend across many agencies, a consensus of gaps and suggested development plans was a major goal of this evaluation and road-mapping effort. The working group consisted of experts representing the Departments of Homeland Security, Health and Human Services (Centers for Disease Control and the National Institutes of Health), Food and Drug Administration, Department of Defense and the Department of Energy's National Laboratories (see appendix A for participants). The specific goals of this Technology Assessment and Roadmap were to: (1) Describe the general context for deployment of emergency radiation dose assessment tools following terrorist use of a radiological or nuclear device; (2) Assess current and emerging dose assessment technologies; and (3) Put forward a consensus high-level technology roadmap for interagency research and development in this area. This report provides a summary of the consensus of needs, gaps and recommendations for a research program in the area of radiation dosimetry for early response, followed by a summary of the technologies available and on the near-term horizon. We then present a roadmap for a research program to bring present and emerging near-term technologies to bear on the gaps in radiation dose assessment and triage. Finally we present detailed supporting discussion on the nature of the threats we considered, the status of technology

  12. Technology Assessment and Roadmap for the Emergency Radiation Dose Assessment Program

    Energy Technology Data Exchange (ETDEWEB)

    Turteltaub, K W; Hartman-Siantar, C; Easterly, C; Blakely, W

    2005-10-03

    A Joint Interagency Working Group (JIWG) under the auspices of the Department of Homeland Security Office of Research and Development conducted a technology assessment of emergency radiological dose assessment capabilities as part of the overall need for rapid emergency medical response in the event of a radiological terrorist event in the United States. The goal of the evaluation is to identify gaps and recommend general research and development needs to better prepare the Country for mitigating the effects of such an event. Given the capabilities and roles for responding to a radiological event extend across many agencies, a consensus of gaps and suggested development plans was a major goal of this evaluation and road-mapping effort. The working group consisted of experts representing the Departments of Homeland Security, Health and Human Services (Centers for Disease Control and the National Institutes of Health), Food and Drug Administration, Department of Defense and the Department of Energy's National Laboratories (see appendix A for participants). The specific goals of this Technology Assessment and Roadmap were to: (1) Describe the general context for deployment of emergency radiation dose assessment tools following terrorist use of a radiological or nuclear device; (2) Assess current and emerging dose assessment technologies; and (3) Put forward a consensus high-level technology roadmap for interagency research and development in this area. This report provides a summary of the consensus of needs, gaps and recommendations for a research program in the area of radiation dosimetry for early response, followed by a summary of the technologies available and on the near-term horizon. We then present a roadmap for a research program to bring present and emerging near-term technologies to bear on the gaps in radiation dose assessment and triage. Finally we present detailed supporting discussion on the nature of the threats we considered, the status of

  13. Hereditary cancer risk assessment: insights and perspectives for the Next-Generation Sequencing era

    Directory of Open Access Journals (Sweden)

    Israel Gomy

    2016-01-01

    Full Text Available Abstract Hereditary cancer risk assessment is a multidisciplinary and dynamic process, with the purpose of estimating probabilities of germline mutations in cancer susceptibility genes and assessing empiric risks of cancer based on personal and family histories, in order to offer clinical and molecular diagnoses and clinical management based on these risks. Genetic tests are available and most of them are reimbursed by insurance companies, although they are generally not covered by the public health systems of developing countries. More recently, molecular diagnosis of hereditary cancer is feasible through next-generation sequencing (NGS panels. Here we review the benefits and limitations of NGS technologies in the clinical practice.

  14. Hereditary cancer risk assessment: insights and perspectives for the Next-Generation Sequencing era.

    Science.gov (United States)

    Gomy, Israel; Diz, Maria Del Pilar Estevez

    2016-05-13

    Hereditary cancer risk assessment is a multidisciplinary and dynamic process, with the purpose of estimating probabilities of germline mutations in cancer susceptibility genes and assessing empiric risks of cancer based on personal and family histories, in order to offer clinical and molecular diagnoses and clinical management based on these risks. Genetic tests are available and most of them are reimbursed by insurance companies, although they are generally not covered by the public health systems of developing countries. More recently, molecular diagnosis of hereditary cancer is feasible through next-generation sequencing (NGS) panels. Here we review the benefits and limitations of NGS technologies in the clinical practice. PMID:27192130

  15. Hereditary cancer risk assessment: insights and perspectives for the Next-Generation Sequencing era

    Science.gov (United States)

    Gomy, Israel; Diz, Maria Del Pilar Estevez

    2016-01-01

    Abstract Hereditary cancer risk assessment is a multidisciplinary and dynamic process, with the purpose of estimating probabilities of germline mutations in cancer susceptibility genes and assessing empiric risks of cancer based on personal and family histories, in order to offer clinical and molecular diagnoses and clinical management based on these risks. Genetic tests are available and most of them are reimbursed by insurance companies, although they are generally not covered by the public health systems of developing countries. More recently, molecular diagnosis of hereditary cancer is feasible through next-generation sequencing (NGS) panels. Here we review the benefits and limitations of NGS technologies in the clinical practice. PMID:27192130

  16. Progress in diagnosis of breast cancer: Advances in radiology technology

    Directory of Open Access Journals (Sweden)

    J Mari Beth Linder

    2015-01-01

    Full Text Available Breast cancer is the leading cause of cancer in females between the ages of 15 and 54, and the second leading cause of cancer death in women in the United States. Diagnosis begins with detection by breast examination (clinical breast exam or breast self-exam or by radiologic studies, like mammography. Many advances in the diagnosis of breast cancer have taken place in recent years. This article will review the history of radiologic advances in the diagnosis of breast cancer. Use of technological advancements in digital breast tomosynthesis, magnetic resonance imaging, and ultrasound in breast cancer diagnosis will be presented. Advantages and disadvantages of these diagnostic interventions when compared to older, traditional X-ray films will be discussed. It is important for all nurses, including radiology and oncology nurses, to be well informed about these varied diagnostic modalities, and appreciate the fact that advances in radiologic imaging technologies can yield improved outcomes for breast cancer patients.

  17. Hereditary cancer risk assessment: essential tools for a better approach

    OpenAIRE

    Gomy, Israel; Estevez Diz, Maria Del Pilar

    2013-01-01

    Hereditary cancer risk assessment (HCRA) is a multidisciplinary process of estimating probabilities of germline mutations in cancer susceptibility genes and assessing empiric risks of cancer, based on personal and family history. It includes genetic counseling, testing and management of at-risk individuals so that they can make well-informed choices about cancer surveillance, surgical treatment and chemopreventive measures, including biomolecular cancer therapies. Providing patients and famil...

  18. Technology Audit: Assessment of Innovative Portfolio

    Directory of Open Access Journals (Sweden)

    Kurushina Viktoria

    2016-01-01

    Full Text Available The article discusses the features of the technological audit performing in the companies of oil and gas sector of Russian economy. To measure the innovations quality level the scale was developed based on the Theory of Inventive Problem Solving and the theory of technological structures. Figures of the innovations quantity by levels, volume and quality of the innovative portfolio are offered for assessment the innovative portfolio quality. The method was tested on an example of oil and gas transporting enterprises. The results of the comparative analysis of innovative portfolio are shown.

  19. Progress in diagnosis of breast cancer: Advances in radiology technology

    OpenAIRE

    J Mari Beth Linder; Alan D Schiska

    2015-01-01

    Breast cancer is the leading cause of cancer in females between the ages of 15 and 54, and the second leading cause of cancer death in women in the United States. Diagnosis begins with detection by breast examination (clinical breast exam or breast self-exam) or by radiologic studies, like mammography. Many advances in the diagnosis of breast cancer have taken place in recent years. This article will review the history of radiologic advances in the diagnosis of breast cancer. Use of technolog...

  20. Inventors Center of Michigan Technical Assessment Program. Final progress report

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-31

    The Technical Assessment Program at the Inventors Center of Michigan is designed to provide independent inventors with a reliable assessment of the technical merits of their proposed inventions. Using faculty from within Ferris State University`s College of Technology an assessment process examines the inventor`s assumptions, documentation, and prototypes, as well as, reviewing patent search results and technical literature to provide the inventor with a written report on the technical aspects of the proposed invention. The forms for applying for a technical assessment of an invention are included.

  1. Assessment of a cancer screening program.

    Science.gov (United States)

    Rabeneck, Linda; Lansdorp-Vogelaar, Iris

    2015-12-01

    Several Asian countries are implementing nationwide cancer screening programs. Assessment of the effectiveness of these programs is critical to their success as this is the only way to ensure that the benefits of screening outweigh the harms. In this paper we focus on colorectal cancer (CRC) screening to illustrate the principles of screening program assessment. The International Agency for Research on Cancer (IARC) has defined organized screening, distinguishing it from opportunistic screening. The key advantage of organized screening is that it provides greater protection against the possible harms of screening. Since screening is a process, not simply a test, the effectiveness of a program depends on the quality of each step in the cancer screening process. The evaluation of long-term screening program outcomes (CRC incidence and mortality) will not be observable for many years, given the time it takes to plan, pilot and implement a program. However, early performance indicators of the impact of screening should be monitored to give an early indication whether the program is on track. The European Union (EU) has recommended a minimum dataset to be collected and reported regularly by a screening program. Using information from these data tables, early performance indicators can be generated (e.g., participation rate, proportion of screen-detected cancers that are early-stage). Subsequently, modeling the natural history of the disease can be very helpful to estimate long-term outcomes, making use of these directly measured early performance indicators. Modeling can also be used to estimate the cost-effectiveness of a screening program and the potential impact of changes in policy, as illustrated by its recent use in the Netherlands to change the definition of a positive fecal immunochemical test (FIT) for the CRC screening program. Programs should consider modeling as an important component of screening program evaluation. PMID:26651258

  2. Coal-fueled diesel: Technology development: Final report

    Energy Technology Data Exchange (ETDEWEB)

    Leonard, G.; Hsu, B.; Flynn, P.

    1989-03-01

    This project consisted of four tasks: (1) to determine if CWM could be ignited and burned rapidly enough for operation in a 1000-rpm diesel engine, (2) to demonstrate that a durable CWM-fueled engine could in principle be developed, (3) to assess current emissions control technology to determine the feasibility of cleaning the exhaust of a CWM-fueled diesel locomotive, and (4) to conduct an economic analysis to determine the attractiveness of powering US locomotives with CWM. 34 refs., 125 figs., 28 tabs.

  3. RECOVERY ACT - Methods for Decision under Technological Change Uncertainty and Risk Assessment for Integrated Assessment of Climate Change

    Energy Technology Data Exchange (ETDEWEB)

    Webster, Mort David [MIT

    2015-03-10

    This report presents the final outcomes and products of the project as performed at the Massachusetts Institute of Technology. The research project consists of three main components: methodology development for decision-making under uncertainty, improving the resolution of the electricity sector to improve integrated assessment, and application of these methods to integrated assessment. Results in each area is described in the report.

  4. Final Report - DOE Center for Laser Imaging and Cancer Diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Alfano, Robert R.; Koutcher, Jason A.

    2002-10-31

    This Final Report summarizes the significant progress made by the researchers, students and staff of the Center for Laser Imaging and Cancer Diagnostics (CLICD) from January 1998 through May 2002. During this period, the Center supported several projects. Most projects were proposed initially, some were added subsequently as their relevance and importance to the DOE mission became evident. DOE support has been leveraged to obtain continuing funding for some projects. Leveraged funds come from various sources, including NIH, Army, NSF and the Air Force. The goal of the Center was to develop laser-based instruments for use in the detection and diagnosis of major diseases, with an emphasis on detection and diagnosis of various cancers. Each of the supported projects is a collaborative effort between physicists and laser scientists and the City College of New York and noted physicians, surgeons, pathologists, and biologists located at medical centers in the Metropolitan area. The participating institutions were: City College of New York Institute for Ultrafast Lasers and Spectroscopy, Hackensack University Medical Center, Lawrence Livermore National Laboratory, Memorial Sloan Kettering Cancer Center, and New York Eye and Ear Institute. Each of the projects funded by the Center is grouped into one of four research categories: a) Disease Detection, b) Non-Disease Applications, c) New Diagnostic Tools, and, d) Education, Training, Outreach and Dissemination. The progress achieved by the multidisciplinary teams was reported in 51 publications and 32 presentations at major national conferences. Also, one U.S. patent was obtained and six U.S. patent applications have been filed for innovations resulting from the projects sponsored by the Center.

  5. MIST Final Report: Multi-sensor Imaging Science and Technology

    Energy Technology Data Exchange (ETDEWEB)

    Lind, Michael A.; Medvick, Patricia A.; Foley, Michael G.; Foote, Harlan P.; Heasler, Patrick G.; Thompson, Sandra E.; Nuffer, Lisa L.; Mackey, Patrick S.; Barr, Jonathan L.; Renholds, Andrea S.

    2008-03-15

    The Multi-sensor Imaging Science and Technology (MIST) program was undertaken to advance exploitation tools for Long Wavelength Infra Red (LWIR) hyper-spectral imaging (HSI) analysis as applied to the discovery and quantification of nuclear proliferation signatures. The program focused on mitigating LWIR image background clutter to ease the analyst burden and enable a) faster more accurate analysis of large volumes of high clutter data, b) greater detection sensitivity of nuclear proliferation signatures (primarily released gasses) , and c) quantify confidence estimates of the signature materials detected. To this end the program investigated fundamental limits and logical modifications of the more traditional statistical discovery and analysis tools applied to hyperspectral imaging and other disciplines, developed and tested new software incorporating advanced mathematical tools and physics based analysis, and demonstrated the strength and weaknesses of the new codes on relevant hyperspectral data sets from various campaigns. This final report describes the content of the program and the outlines the significant results.

  6. Natural-technological risk assessment and management

    Science.gov (United States)

    Burova, Valentina; Frolova, Nina

    2016-04-01

    EM-DAT statistical data on human impact and economic damages in the 1st semester 2015 are the highest since 2011: 41% of disasters were floods, responsible for 39% of economic damage and 7% of events were earthquakes responsible for 59% of total death toll. This suggests that disaster risk assessment and management still need to be improved and stay the principle issue in national and international related programs. The paper investigates the risk assessment and management practice in the Russian Federation at different levels. The method is proposed to identify the territories characterized by integrated natural-technological hazard. The maps of the Russian Federation zoning according to the integrated natural-technological hazard level are presented, as well as the procedure of updating the integrated hazard level taking into account the activity of separate processes. Special attention is paid to data bases on past natural and technological processes consequences, which are used for verification of current hazard estimation. The examples of natural-technological risk zoning for the country and some regions territory are presented. Different output risk indexes: both social and economic, are estimated taking into account requirements of end-users. In order to increase the safety of population of the Russian Federation the trans-boundaries hazards are also taken into account.

  7. Finding Qualitative Research Evidence for Health Technology Assessment.

    Science.gov (United States)

    DeJean, Deirdre; Giacomini, Mita; Simeonov, Dorina; Smith, Andrea

    2016-08-01

    Health technology assessment (HTA) agencies increasingly use reviews of qualitative research as evidence for evaluating social, experiential, and ethical aspects of health technologies. We systematically searched three bibliographic databases (MEDLINE, CINAHL, and Social Science Citation Index [SSCI]) using published search filters or "hedges" and our hybrid filter to identify qualitative research studies pertaining to chronic obstructive pulmonary disease and early breast cancer. The search filters were compared in terms of sensitivity, specificity, and precision. Our screening by title and abstract revealed that qualitative research constituted only slightly more than 1% of all published research on each health topic. The performance of the published search filters varied greatly across topics and databases. Compared with existing search filters, our hybrid filter demonstrated a consistently high sensitivity across databases and topics, and minimized the resource-intensive process of sifting through false positives. We identify opportunities for qualitative health researchers to improve the uptake of qualitative research into evidence-informed policy making. PMID:27117960

  8. Inhalation cancer risk assessment of cobalt metal.

    Science.gov (United States)

    Suh, Mina; Thompson, Chad M; Brorby, Gregory P; Mittal, Liz; Proctor, Deborah M

    2016-08-01

    Cobalt compounds (metal, salts, hard metals, oxides, and alloys) are used widely in various industrial, medical and military applications. Chronic inhalation exposure to cobalt metal and cobalt sulfate has caused lung cancer in rats and mice, as well as systemic tumors in rats. Cobalt compounds are listed as probable or possible human carcinogens by some agencies, and there is a need for quantitative cancer toxicity criteria. The U.S. Environmental Protection Agency has derived a provisional inhalation unit risk (IUR) of 0.009 per μg/m(3) based on a chronic inhalation study of soluble cobalt sulfate heptahydrate; however, a recent 2-year cancer bioassay affords the opportunity to derive IURs specifically for cobalt metal. The mechanistic data support that the carcinogenic mode of action (MOA) is likely to involve oxidative stress, and thus, non-linear/threshold mechanisms. However, the lack of a detailed MOA and use of high, toxic exposure concentrations in the bioassay (≥1.25 mg/m(3)) preclude derivation of a reference concentration (RfC) protective of cancer. Several analyses resulted in an IUR of 0.003 per μg/m(3) for cobalt metal, which is ∼3-fold less potent than the provisional IUR. Future research should focus on establishing the exposure-response for key precursor events to improve cobalt metal risk assessment. PMID:27177823

  9. Navy radon assessment and mitigation program: Final report

    International Nuclear Information System (INIS)

    This final report encompasses the events from the beginning of the Navy Radon Assessment and Mitigation Program to the closure of the program on October 31, 1994. Included in the report are discussions of the phases of the program including screening, assessment, mitigation, and post-mitigation. The primary discussion involves screening and assessment. The report addresses recommendations made to the Naval Facilities Engineering Command by the Hazardous Waste Remedial Actions Program of Martin Marietta Energy Systems, Inc., and the final decisions that were made. Special emphasis is placed on quality assurance/quality control (QA/QC), since QA/QC was given top priority during the implementation of this program. Included in the discussion on QA/QC are ana overview of the measurement process, positive and negative controls, replicated measurements, and application of chamber exposures to data calibration. The report concludes with a discussion of testing considerations for naval facilities and radon mitigation considerations for the Department of the Navy

  10. Value and indications of liver scintigraphy in the initial assessment of bronchopulmonary cancers

    International Nuclear Information System (INIS)

    This retrospective study of 117 liver scintigraphs, carried out systematically in the initial examination of bronchopulmonary cancer patients, attempts to define the value and indications of the method in the diagnosis of liver metastases at the stage when the primary cancer is discovered. Its sensitivity and reliability were estimated by comparing the interpretation of the scan with the actual situation. Scintigraphic diagnosis meets with several difficulties. It is ruled by technology: in spite of many improvements it seems that the quality of conventional scintigraphy has reached its limits, through transverse axial tomodensitometry may be a future solution. Morever its interpretation depends on the experience and temperament of the observer, as shown by the results of double-blind readings. Finally the examination is not specific to the nature of the liver disease. It seems that without prejudice to the patient the indications of liver scintigraphy in the initial assessment of bronchopulmonary cancer may be limited to cases where some clinical or biological doubt on the integrity of the liver is present

  11. Breast Cancer Risk Assessment SAS Macro (Gail Model)

    Science.gov (United States)

    A SAS macro (commonly referred to as the Gail Model) that projects absolute risk of invasive breast cancer according to NCI’s Breast Cancer Risk Assessment Tool (BCRAT) algorithm for specified race/ethnic groups and age intervals.

  12. Technology assessment of wind energy conversion systems

    Energy Technology Data Exchange (ETDEWEB)

    Meier, B. W.; Merson, T. J.

    1980-09-01

    Environmental data for wind energy conversion systems (WECSs) have been generated in support of the Technology Assessment of Solar Energy (TASE) program. Two candidates have been chosen to characterize the WECS that might be deployed if this technology makes a significant contribution to the national energy requirements. One WECS is a large machine of 1.5-MW-rated capacity that can be used by utilities. The other WECS is a small machine that is characteristic of units that might be used to meet residential or small business energy requirements. Energy storage systems are discussed for each machine to address the intermittent nature of wind power. Many types of WECSs are being studied and a brief review of the technology is included to give background for choosing horizontal axis designs for this study. Cost estimates have been made for both large and small systems as required for input to the Strategic Environmental Assessment Simulation (SEAS) computer program. Material requirements, based on current generation WECSs, are discussed and a general discussion of environmental impacts associated with WECS deployment is presented.

  13. Tiger Team Assessment, Energy Technology Engineering Center

    Energy Technology Data Exchange (ETDEWEB)

    1991-04-01

    The Office Special Projects within the Office of Environment, Safety, and Health (EH) has the responsibility to conduct Tiger Team Assessments for the Secretary of Energy. This report presents the assessment of the buildings, facilities, and activities under the DOE/Rockwell Contract No. DE-AM03-76SF00700 for the Energy Technology Engineering Center (ETEC) and of other DOE-owned buildings and facilities at the Santa Susana Field Laboratory (SSFL) site in southeastern Ventura County, California, not covered under Contract No. DE-AM03-76SF00700, but constructed over the years under various other contracts between DOE and Rockwell International. ETEC is an engineering development complex operated for DOE by the Rocketdyne Division of Rockwell International Corporation. ETEC is located within SSFL on land owned by Rockwell. The balance of the SSFL complex is owned and operated by Rocketdyne, with the exception of a 42-acre parcel owned by the National Aeronautics and Space Administration (NASA). The primary mission of ETEC is to provide engineering, testing, and development of components related to liquid metals technology and to conduct applied engineering development of emerging energy technologies.

  14. Tiger Team Assessment, Energy Technology Engineering Center

    International Nuclear Information System (INIS)

    The Office Special Projects within the Office of Environment, Safety, and Health (EH) has the responsibility to conduct Tiger Team Assessments for the Secretary of Energy. This report presents the assessment of the buildings, facilities, and activities under the DOE/Rockwell Contract No. DE-AM03-76SF00700 for the Energy Technology Engineering Center (ETEC) and of other DOE-owned buildings and facilities at the Santa Susana Field Laboratory (SSFL) site in southeastern Ventura County, California, not covered under Contract No. DE-AM03-76SF00700, but constructed over the years under various other contracts between DOE and Rockwell International. ETEC is an engineering development complex operated for DOE by the Rocketdyne Division of Rockwell International Corporation. ETEC is located within SSFL on land owned by Rockwell. The balance of the SSFL complex is owned and operated by Rocketdyne, with the exception of a 42-acre parcel owned by the National Aeronautics and Space Administration (NASA). The primary mission of ETEC is to provide engineering, testing, and development of components related to liquid metals technology and to conduct applied engineering development of emerging energy technologies

  15. Radiation detection technology assessment program (RADTAP)

    International Nuclear Information System (INIS)

    The U.S. Customs Service and the U.S. Department of Energy (DOE) conducted a technical and operational assessment of gamma ray radiation detection equipment during the period May 5-16, 1997 at a testing facility in North Carolina. The effort was entitled, ''Radiation Detection Technology Assessment Program (RADTAP)'', and was conducted for the purpose of assessing the applicability, sensitivity and robustness of a diverse suite of gamma ray detection and identification equipment for possible use by Customs and other law enforcement agencies. Thirteen companies entered 25 instruments into the assessment program. All detection equipment entered had to exhibit a minimum sensitivity of 20 micro-R per hour (background included) from a Cesium-137 point source. Isotope identifying spectrometers entered were man portable and operable at room temperature with read-out that could be interpreted by non-technical personnel. Radioactive sources used in the assessment included special nuclear material, industrial and health isotopes. Evaluators included Customs inspectors and technical experts from DOE and Customs. No conclusions or recommendations were issued based on the quantitative and qualitative test results, however, the results of the program provided law enforcement agencies with the necessary data to select equipment that best meets their operational needs and budgets. (author)

  16. Constructive technology assessment and technology dynamics: the case of clean technologies

    NARCIS (Netherlands)

    Schot, Johan W.

    1992-01-01

    A synthesis of neo-Schumpeterian evolutionary, sociological, and historical coevolution ary models could be used for constructive technology assessment, aimed at the active management of the process of technological change. This article proposes a synthetic quasi-evolutionary model, in which variati

  17. Constructive technology assessment and technology dynamics: the case of clean technologies

    OpenAIRE

    Schot, Johan W.

    1992-01-01

    A synthesis of neo-Schumpeterian evolutionary, sociological, and historical coevolution ary models could be used for constructive technology assessment, aimed at the active management of the process of technological change. This article proposes a synthetic quasi-evolutionary model, in which variation and selection are neither independent nor coincidental processes. Variation and selection are linked by actors, resulting in the actor role labeled technological nexus. On the basis of the quasi...

  18. Nano technology in cancer diagnosis and treatment : An Overview

    Directory of Open Access Journals (Sweden)

    Rathy Ravindran

    2011-01-01

    Full Text Available Nanotechnology provide innovative tools that shed greater light on life cycle of normal cells andthe point at which molecular processes and changes within cells become correlated with development ofcancer. It should be possible to obtain large amount of information from a small source. They aid inanalysis of parameters such as cellular mechanics, morphology and cytoskeleton which has been hard toachieve using conventional technology.Nano devices can detect cancer cells, identify cancer signatures and provide targeted delivery ofanti cancer therapeutics and contrast agents to tumour cells. The obstacle to early detection of cancer liesin the liability of existing tools to detect molecular level changes during early phases in the developmentof cancer. Nano Technology is potential tool that could help detect the molecular changes and assist infocusing on preventive efforts.

  19. Probabilistic risk assessment (PRA) reference document. Final report

    International Nuclear Information System (INIS)

    This document describes the current status of probabilistic risk assessment (PRA) as practiced in the nuclear reactor regulatory process. The PRA studies that have been completed or are under way are reviewed. The levels of maturity of the methodologies used in a PRA are discussed. Insights derived from PRAs are listed. The potential uses of PRA results for regulatory purposes are discussed. This document was issued for comment in February 1984 entitled Probabilistic Risk Assessment (PRA): Status Report and Guidance for Regulatory Application. The comments received on the draft have been considered for this final version of the report

  20. Nutritional status assessment in colorectal cancer patients

    Directory of Open Access Journals (Sweden)

    Joana Pedro Lopes

    2013-04-01

    Full Text Available The present study intended to evaluate the nutritional status of Portuguese colorectal patients and associated it with surgery type as well as quality of life outcomes. Malnutrition can affect up to 85% of cancer patients and specifically 30-60% in colorectal cancer and can significantly influence health outcomes. A sample of 50 colorectal cancer patients was evaluated in what refers to several anthropometric measures, food intake, clinical history, complications rate before and after surgery procedure. The sample was divided between convention and fast-track procedures. Most of the individuals were overweight or obese but had lost weight on the past six months. Despite mild, there were signs of malnutrition in this sample with high losses of fat free mass, weight and also fat mass during the hospitalization period. These results reinforce the importance of malnutrition assessment in colorectal patients as well as consider weight loss on the past months and body composition in order to complement nutritional status evaluation.

  1. Integrated Operations Architecture Technology Assessment Study

    Science.gov (United States)

    2001-01-01

    As part of NASA's Integrated Operations Architecture (IOA) Baseline, NASA will consolidate all communications operations. including ground-based, near-earth, and deep-space communications, into a single integrated network. This network will make maximum use of commercial equipment, services and standards. It will be an Internet Protocol (IP) based network. This study supports technology development planning for the IOA. The technical problems that may arise when LEO mission spacecraft interoperate with commercial satellite services were investigated. Commercial technology and services that could support the IOA were surveyed, and gaps in the capability of existing technology and techniques were identified. Recommendations were made on which gaps should be closed by means of NASA research and development funding. Several findings emerged from the interoperability assessment: in the NASA mission set, there is a preponderance of small. inexpensive, low data rate science missions; proposed commercial satellite communications services could potentially provide TDRSS-like data relay functions; and. IP and related protocols, such as TCP, require augmentation to operate in the mobile networking environment required by the space-to-ground portion of the IOA. Five case studies were performed in the technology assessment. Each case represented a realistic implementation of the near-earth portion of the IOA. The cases included the use of frequencies at L-band, Ka-band and the optical spectrum. The cases also represented both space relay architectures and direct-to-ground architectures. Some of the main recommendations resulting from the case studies are: select an architecture for the LEO/MEO communications network; pursue the development of a Ka-band space-qualified transmitter (and possibly a receiver), and a low-cost Ka-band ground terminal for a direct-to-ground network, pursue the development of an Inmarsat (L-band) space-qualified transceiver to implement a global, low

  2. Epigenetic processes and cancer risk assessment

    International Nuclear Information System (INIS)

    The U.S. Environmental Protection Agency's Guidelines for Carcinogen Risk Assessment encourages the use of mechanistic data in the assessment of human cancer risk at low (environmental) exposure levels. The key events that define a particular mode of action for tumor formation have been concentrated to date more on mutational responses that are broadly the result of induced DNA damage and enhanced cell proliferation. While it is clear that these processes are important in terms of tumor induction, other modes that fall under the umbrella of epigenetic responses are increasingly being considered to play an important role in susceptibility to tumor induction by environmental chemicals and as significant modifiers of tumor responses. Alterations in gene expression, DNA repair, cell cycle control, genome stability and genome reprogramming could be the result of modification of DNA methylation and chromatin remodeling patterns as a consequence of exposure to environmental chemicals. These concepts are described and discussed

  3. Electronic game: A key effective technology to promote behavioral change in cancer patients.

    Science.gov (United States)

    Safdari, Reza; Ghazisaeidi, Marjan; Goodini, Azadeh; Mirzaee, Mahboobeh; Farzi, Jebraeil

    2016-01-01

    Cancer diagnosis is a very unpleasant and unbelievable experience. Appropriate management and treatment of these diseases require a high degree of patient engagement. Interactive health electronic games are engaging, fun, challenging, and experiential and have the potential to change the attitude and behavior, which can improve the player's health. The use of these digital tools, as one of the most attractive and entertaining modern technologies, canem power patients, provide suitable palliative care, promote health behavior change strategies, increase patient engagement, enhance healthy lifestyle habits, improve self.management, and finally improve the quality of life of the patients. Finally, the aim of this article was to describe electronic games and their effects on the promotion of behavior change in cancer patients. In addition, this article describes categories, characteristic features, and benefits of this digital media in the lifestyle modification of cancer patients. PMID:27461596

  4. Bringing Breast Cancer Technologies to Market | Poster

    Science.gov (United States)

    CCR research is recognized in novel competition to encourage the commercialization of breast cancer inventions. Editor’s note: This article was originally published in CCR Connections (Volume 8, No. 1). The Breast Cancer Startup Challenge was named one of six finalists in the HHS Innovates Award Competition, and was one of three finalists recognized by HHS Secretary Sylvia Mathews Burwell and Deputy Secretary Bill Corr. For more information on the Challenge, see previous article on the Poster website. Start-up companies are instrumental in bringing the fruits of scientific research to market. Recognizing an opportunity to bring entrepreneurial minds to bear on the diagnosis and treatment of breast cancer, the Avon Foundation for Women partnered with NCI and the Center for Advancing Innovation to launch the Breast Cancer Startup Challenge.

  5. Aptamers: A Feasible Technology in Cancer Immunotherapy

    Science.gov (United States)

    Villanueva, H.; Pastor, F.

    2016-01-01

    Aptamers are single-chained RNA or DNA oligonucleotides (ODNs) with three-dimensional folding structures which allow them to bind to their targets with high specificity. Aptamers normally show affinities comparable to or higher than that of antibodies. They are chemically synthesized and therefore less expensive to manufacture and produce. A variety of aptamers described to date have been shown to be reliable in modulating immune responses against cancer by either blocking or activating immune receptors. Some of them have been conjugated to other molecules to target the immune system and reduce off-target side effects. Despite the success of first-line treatments against cancer, the elevated number of relapsing cases and the tremendous side effects shown by the commonly used agents hinder conventional treatments against cancer. The advantages provided by aptamers could enhance the therapeutic index of a given strategy and therefore enhance the antitumor effect. Here we recapitulate the provided benefits of aptamers with immunomodulatory activity described to date in cancer therapy and the benefits that aptamer-based immunotherapy could provide either alone or combined with first-line treatments in cancer therapy. PMID:27413756

  6. Final voluntary release assessment/corrective action report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-12

    The US Department of Energy, Carlsbad Area Office (DOE-CAO) has completed a voluntary release assessment sampling program at selected Solid Waste Management Units (SWMUs) at the Waste Isolation Pilot Plant (WIPP). This Voluntary Release Assessment/Corrective Action (RA/CA) report has been prepared for final submittal to the Environmental protection Agency (EPA) Region 6, Hazardous Waste Management Division and the New Mexico Environment Department (NMED) Hazardous and Radioactive Materials Bureau to describe the results of voluntary release assessment sampling and proposed corrective actions at the SWMU sites. The Voluntary RA/CA Program is intended to be the first phase in implementing the Resource Conservation and Recovery Act (RCRA) Facility Investigation (RFI) and corrective action process at the WIPP. Data generated as part of this sampling program are intended to update the RCRA Facility Assessment (RFA) for the WIPP (Assessment of Solid Waste Management Units at the Waste Isolation Pilot Plant), NMED/DOE/AIP 94/1. This Final Voluntary RA/CA Report documents the results of release assessment sampling at 11 SWMUs identified in the RFA. With this submittal, DOE formally requests a No Further Action determination for these SWMUs. Additionally, this report provides information to support DOE`s request for No Further Action at the Brinderson and Construction landfill SWMUs, and to support DOE`s request for approval of proposed corrective actions at three other SWMUs (the Badger Unit Drill Pad, the Cotton Baby Drill Pad, and the DOE-1 Drill Pad). This information is provided to document the results of the Voluntary RA/CA activities submitted to the EPA and NMED in August 1995.

  7. Cancer Risk Assessment: Should New Science be Applied? Workgroup summary

    Energy Technology Data Exchange (ETDEWEB)

    Richard J. Bull; Antone L. Brooks

    2002-12-15

    OAK-B135 A symposium discussing the implications of certain phenomena observed in radiation biology for cancer risk assessment in general. In July of 2002 a workshop was convened that explored some of the intercellular phenomena that appear to condition responses to carcinogen exposure. Effects that result from communication between cells that appear to either increase the sphere of damage or to modify the sensitivity of cells to further damage were of particular interest. Much of the discussion focused on the effects of ionizing radiation that were transmitted from cells directly hit to cells not receiving direct exposure to radiation (bystander cells). In cell culture, increased rates of mutation, chromosomal aberration, apoptosis, genomic instability, and decreased clonogenic survival have all been observed in cells that have experienced no direct radiation. In addition, there is evidence that low doses of radiation or certain chemicals give rise to adaptive responses in which the treated cells develop resistance to the effects of high doses given in subsequent exposures. Data were presented at the workshop indicating that low dose exposure of animals to radiation and some chemicals frequently reduces the spontaneous rate of mutation in vitro and tumor responses in vivo. Finally, it was concluded that considerable improvement in understanding of how genetic variation may modify the impact of these phenomena is necessary before the risk implications can be fully appreciated. The workshop participants discussed the substantive challenge that these data present with respect to simple linear methodologies that are currently used in cancer risk assessment and attempted to identify broad strategies by which these phenomena may start to be used to refine cancer risk assessment methods in the future.

  8. Life cycle assessment of biogas upgrading technologies.

    Science.gov (United States)

    Starr, Katherine; Gabarrell, Xavier; Villalba, Gara; Talens, Laura; Lombardi, Lidia

    2012-05-01

    This article evaluates the life cycle assessment (LCA) of three biogas upgrading technologies. An in-depth study and evaluation was conducted on high pressure water scrubbing (HPWS), as well as alkaline with regeneration (AwR) and bottom ash upgrading (BABIU), which additionally offer carbon storage. AwR and BABIU are two novel technologies that utilize waste from municipal solid waste incinerators - namely bottom ash (BA) and air pollution control residues (APC) - and are able to store CO(2) from biogas through accelerated carbonation processes. These are compared to high pressure water scrubbing (HPWS) which is a widely used technology in Europe. The AwR uses an alkaline solution to remove the CO(2) and then the solution - rich in carbonate and bicarbonate ions - is regenerated through carbonation of APC. The BABIU process directly exposes the gas to the BA to remove and immediately store the CO(2), again by carbonation. It was determined that the AwR process had an 84% higher impact in all LCA categories largely due to the energy intensive production of the alkaline reactants. The BABIU process had the lowest impact in most categories even when compared to five other CO(2) capture technologies on the market. AwR and BABIU have a particularly low impact in the global warming potential category as a result of the immediate storage of the CO(2). For AwR, it was determined that using NaOH instead of KOH improves its environmental performance by 34%. For the BABIU process the use of renewable energies would improve its impact since accounts for 55% of the impact. PMID:22230660

  9. New technologies - How to assess environmental effects

    Science.gov (United States)

    Sullivan, P. J.; Lavin, M. L.

    1981-01-01

    A method is provided for assessing the environmental effects of a room-and-pillar mining system (RP) and a new hydraulic borehole mining system (HBM). Before environmental assessment can begin, each technology is defined in terms of its engineering characteristics at both the conceptual and preliminary design stages. The mining sites are also described in order to identify the significant advantages and constraints for each system. This can be a basic physical and biological survey of the region at the conceptual stage, but a more specific representation of site characteristics is required at the preliminary stage. Assessment of potential environmental effects of each system at the conceptual design is critical to its hardware development and application. A checklist can be used to compare and identify the negative impacts of each method, outlining the resource affected, the type of impact involved, and the exact activity causing that impact. At the preliminary design stage, these impacts should be evaluated as a result of either utilization or alteration. Underground coal mining systems have three major utilization impacts - the total area disturbed, the total water resources withdrawn from other uses, and the overall energy efficiency of the process - and one major alteration impact - the degradation of water quality by sedimentation and acid contamination. A comparison of the RP and HBM systems shows the HBM to be an environmentally less desirable system for the Central Appalachia region.

  10. Bridges between science, society and policy technology assessment : methods and impacts

    CERN Document Server

    Ladikas, Miltos

    2004-01-01

    This book summarises the results of the project TAMI (Technology Assessment in Europe; between Method and Impact). This was a two-year project that brought together the main institutes of technology assessment in Europe, both parliamentary and non-parliamentary. TAMI created a structured dialogue between technology assessment experts and policymakers on current methodologies and their impact on policymaking. The TAMI team explored and assessed the whole spectrum of methodologies from the "classical" to the "interactive/participatory" and "communicative," identified good practices in project implementation and set the stage for impact evaluation based on objective criteria. Finally this report offers a series of policy recommendations based on the findings of the project. Science, Society and Policy, are three areas that technology assessment functions within and works for; this book is an attempt to improve the interaction amongst them for a more socially and economically sustainable Science and Technology p...

  11. Efficacy of a touchscreen computer based family cancer history questionnaire and subsequent cancer risk assessment

    OpenAIRE

    Westman, J; Hampel, H.; Bradley, T.

    2000-01-01

    OBJECTIVE—A computer based touchscreen family cancer history questionnaire was developed and implemented to facilitate the provision of cancer risk assessments for the ambulatory and outpatient populations of a free standing cancer hospital.
METHODS—A questionnaire consisting of a series of branched point decision making screens was developed which enables the participant to enter demographic data, personal cancer history, and cancer histories for first and second degree relatives. A freestan...

  12. Breast cancer risk and historical exposure to pesticides from wide-area applications assessed with GIS.

    OpenAIRE

    Brody, Julia Green; Aschengrau, Ann; McKelvey, Wendy; Rudel, Ruthann A.; Swartz, Christopher H.; Kennedy, Theresa

    2004-01-01

    Pesticides are of interest in etiologic studies of breast cancer because many mimic estrogen, a known breast cancer risk factor, or cause mammary tumors in animals, but most previous studies have been limited by using one-time tissue measurements of residues of only a few pesticides long banned in the United States. As an alternative method to assess historical exposures to banned and current-use pesticides, we used geographic information system (GIS) technology in a population-based case-con...

  13. Drug delivery system innovation and Health Technology Assessment: Upgrading from Clinical to Technological Assessment.

    Science.gov (United States)

    Panzitta, Michele; Bruno, Giorgio; Giovagnoli, Stefano; Mendicino, Francesca R; Ricci, Maurizio

    2015-11-30

    Health Technology Assessment (HTA) is a multidisciplinary health political instrument that evaluates the consequences, mainly clinical and economical, of a health care technology; the HTA aim is to produce and spread information on scientific and technological innovation for health political decision making process. Drug delivery systems (DDS), such as nanocarriers, are technologically complex but they have pivotal relevance in therapeutic innovation. The HTA process, as commonly applied to conventional drug evaluation, should upgrade to a full pharmaceutical assessment, considering the DDS complexity. This is useful to study more in depth the clinical outcome and to broaden its critical assessment toward pharmaceutical issues affecting the patient and not measured by the current clinical evidence approach. We draw out the expertise necessary to perform the pharmaceutical assessment and we propose a format to evaluate the DDS technological topics such as formulation and mechanism of action, physicochemical characteristics, manufacturing process. We integrated the above-mentioned three points in the Evidence Based Medicine approach, which is data source for any HTA process. In this regard, the introduction of a Pharmaceutics Expert figure in the HTA could be fundamental to grant a more detailed evaluation of medicine product characteristics and performances and to help optimizing DDS features to overcome R&D drawbacks. Some aspects of product development, such as manufacturing processes, should be part of the HTA as innovative manufacturing processes allow new products to reach more effectively patient bedside. HTA so upgraded may encourage resource allocating payers to invest in innovative technologies and providers to focus on innovative material properties and manufacturing processes, thus contributing to bring more medicines in therapy in a sustainable manner. PMID:26399633

  14. Assessing non-resectability of lung cancer

    International Nuclear Information System (INIS)

    To investigate whether the assessment of resectability of lung cancer can be reliably made on the basis of computed tomography (CT), the thoracic CT scans of 96 lung cancer patients who were operated on, and in whom the tumour was classified to be of stage III at preoperative CT or at thoracotomy, were analysed. Of the patients, 58 underwent complete resection of the tumour, whereas thoracotomy resulted in non-complete resection or exploration only in 38 cases. Overlapping of the CT findings in the groups of complete and non-successful resection was observed. The majority of tumours with apparent growth to the carina, trachea, oesophagus or great vessels at CT were completely resected. Tumours that only bordered on the pleura could not be distinguished from those with pleural invasion. Mediastinal lymph node enlargement did not always mean metastatic spread. We conclude that there is no definite sign that identifies non-resectability of lung tumours, and a certain proportion of non-curative thoracotomies must be accepted. (orig.)

  15. Louisiana Industrial Assessment Center--Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Theodore A. Kozman

    2007-10-17

    This is the Final Report for the Louisiana Industrial Assessment Center for the period of 9/1/2002 through 11/30/2006, although we were still gathering data through 02/16/2007. During this period, our Industrial Assessment Center completed 109 energy assessments for manufacturing firms in our area, offered 3 Save Energy Workshops, taught 26 students (9 graduate and 17 undergraduate) energy management savings techniques and offered an Energy Management Graduate class three times. These 109 energy assessments made a total of 738 energy savings recommendations, 33 waste reduction recommendations, and 108 productivity improvement recommendations. These combined recommendations would save client companies more than $87,741,221.16, annually at the then current energy costs. If all of these recommendations were implemented separately, the implementation cost would have been $34,113,482.10 or a Simple Payback Period, SPP=4.7 months. Between 9 months and 12 months after the assessment, we surveyed the manufacturing firms to find out what they implemented. They had implemented approximately 50 percent of our recommendations at an annual saving of $25,867,613.18. The three Save Energy Workshops had an average attendance of twelve individuals. The three graduate Energy Management courses had an average attendance of eleven students.

  16. Cancer risk assessments and environmental regulation

    International Nuclear Information System (INIS)

    Governmental regulation of toxic substances, such as carcinogens and radiation, prompts both legal and scientific controversies. Industry, environmental activist groups, government regulators, and the general public are all concerned with the question of how environmental risk to public health is to be measured and what level of risk warrants government action under the environmental laws. Several recent events shed light on the fundamental scientific and legal problems inherent in such regulation, and these events may affect the direction of future developments. These events include implementation of generic Risk Assessment Guidelines by the US EPA, litigation challenging EPA's regulation of carcinogenic substances, new scientific understanding of the relative risks from human exposure to natural and man-made sources, and the continuing growth of toxic tort litigation in which victims of cancer seek large damages from industrial emitters of pollution

  17. Networking and Information Technology Workforce Study: Final Report

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — This report presents the results of a study of the global Networking and Information Technology NIT workforce undertaken for the Networking and Information...

  18. Nano technology for imaging and drug delivery in cancer

    International Nuclear Information System (INIS)

    Nanoparticles are multifunctional in characteristics and may be used for diagnosis as well as treatment of cancer. Nanoparticles enhance permeability, retention effects and target the tumor by avoiding reticuloendothelial system. The various nano technological approaches are used in treatment of the diseases and imaging of biological materials; like localized delivery of heat by nanoparticles, mini emulsion polymerization by nanoparticles, nanoparticles responsive to pH gradient and Nanoparticles along with ultrasonic radiations. In future, new herbal nanoparticles may be proved better in treatment of cancer and may improve life style of cancer patient. (author)

  19. Advanced Technology Training Program for the Apparel Industry. Final Report.

    Science.gov (United States)

    El Paso Community Coll., TX.

    A project developed rapid response, advanced technology courses that met the apparel market labor needs of the El Paso (Texas) community. Courses were designed for four options: computerized marker making and pattern grading, computerized front office systems, high technology machinery operation, and high technology machinery mechanics. The…

  20. Technology assessment Jordan Nuclear Power Plant Project

    International Nuclear Information System (INIS)

    Preliminary regional analysis was carried out for identification of potential sites for NPP, followed by screening of these sites and selecting candidate sites. Aqaba sites are proposed, where it can use the sea water for cooling: i.Site 1; at the sea where it can use the sea water for direct cooling. ii.Site 2; 10 km to the east of Gulf of Aqaba shoreline at the Saudi Arabia borders. iii.Site 3, 4 km to the east of Gulf of Aqaba shoreline. Only the granitic basement in the east of the 6 km²site should be considered as a potential site for a NPP. Preliminary probabilistic seismic hazard assessment gives: Operating-Basis Earthquake-OBE (475 years return period) found to be in the range of 0.163-0.182 g; Safe Shutdown Earthquake-SSE (10,000 years return period) found to be in the range of 0.333-0.502g. The process include also setting up of nuclear company and other organizational matters. Regulations in development are: Site approval; Construction permitting; Overall licensing; Safety (design, construction, training, operations, QA); Emergency planning; Decommissioning; Spent fuel and RW management. JAEC's technology assessment strategy and evaluation methodology are presented

  1. Aptamers: A Feasible Technology in Cancer Immunotherapy

    OpenAIRE

    Soldevilla, M. M.; H. Villanueva; Pastor, F. (Fernando)

    2016-01-01

    Aptamers are single-chained RNA or DNA oligonucleotides (ODNs) with three-dimensional folding structures which allow them to bind to their targets with high specificity. Aptamers normally show affinities comparable to or higher than that of antibodies. They are chemically synthesized and therefore less expensive to manufacture and produce. A variety of aptamers described to date have been shown to be reliable in modulating immune responses against cancer by either blocking or activating immun...

  2. Actual Radiodiagnosis Technologies of Hepatic Cancer

    OpenAIRE

    Cheremisinova I.S.; Shakhov B.Е.

    2012-01-01

    The aim of the investigation was to study the possibilities of computer tomography with intravenous contrast and multiphase scanning and magnetic resonance tomography using hepatospecific contrast substance — gadoxetic acid — in hepatic cancer diagnostics. Materials and Methods. Within the period of 2008–2011 on the basis of Kirov Regional War Veterans Hospital and Kirov Regional Clinical Hospital there was carried out the complete clinical and radiological examination of 60 patients with...

  3. Environmental assessment of advanced thin film manufacturing process. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Cunningham, D.W.; Mopas, E.; Skinner, D. [BP Solar, Inc., Fairfield, CA (United States); McGuire, L.; Strehlow, M. [Radian International, Walnut Creek, CA (United States)

    1998-09-01

    This report describes work performed by BP Solar, Inc., to provide an extensive preproduction analysis of waste-stream abatement at its plant in Fairfield, California. During the study, numerous technologies were thoroughly evaluated, which allowed BP Solar to select systems that outperformed the stringent federal and state regulations. The main issues were originally perceived to be controlling cadmium compound releases to both air and wastewater to acceptable levels and adopting technologies for air and water waste streams in an efficient, cost-effective manner. BP Solar proposed high-efficiency, reliable control equipment that would reduce air-contaminant emission levels below levels of concern. Cadmium telluride dust is successfully controlled with high-efficiency (>99.9%) bag-in/bag-out filters. For air abatement, carbon canisters provide efficient VOC reduction, and wastewater pretreatment is required per federal pretreatment standards. BP Solar installed a cadmium-scavenging ion exchange system and electrowinning system capable of removing cadmium to <10 ppb (local publicly-owned-treatment-works limits for cadmium is 30 ppb). BP Solar plans to maximize potential reuse of rinse waters by phasing in additional wastewater treatment technologies. Finally, the work to date has identified the areas that need to be revisited as production scales up to ensure that all health, safety, and environmental goals are met.

  4. Development of integrated accident management assessment technology

    International Nuclear Information System (INIS)

    This project aims to develop critical technologies for accident management through securing evaluation frameworks and supporting tools, in order to enhance capabilities coping with severe accidents. For the research goal, firstly under the viewpoint of accident prevention, on-line risk monitoring system and the analysis framework for human error have been developed. Secondly, the training/supporting systems including the training simulator and the off-site risk evaluation system have been developed to enhance capabilities coping with severe accidents. Four kinds of research results have been obtained from this project. Firstly, the framework and taxonomy for human error analysis has been developed for accident management. As the second, the supporting system for accident managements has been developed. Using data that are obtained through the evaluation of off-site risk for Younggwang site, the risk database as well as the methodology for optimizing emergency responses has been constructed. As the third, a training support system, SAMAT, has been developed, which can be used as a training simulator for severe accident management. Finally, on-line risk monitoring system, DynaRM, has been developed for Ulchin 3 and 4 unit

  5. Technology-Based Classroom Assessments: Alternatives to Testing

    Science.gov (United States)

    Salend, Spencer J.

    2009-01-01

    Although many teachers are using new technologies to differentiate instruction and administer tests, educators are also employing a range of technology-based resources and strategies to implement a variety of classroom assessments as alternatives to standardized and teacher-made testing. Technology-based classroom assessments focus on the use of…

  6. Disparities in Cancer Genetic Risk Assessment and Testing.

    Science.gov (United States)

    Underhill, Meghan L; Jones, Tarsha; Habin, Karleen

    2016-07-01

    Scientific and technologic advances in genomics have revolutionized genetic counseling and testing, targeted therapy, and cancer screening and prevention. Among younger women, African American and Hispanic women have a higher rate of cancers that are associated with hereditary cancer risk, such as triple-negative breast cancer, which is linked to poorer outcomes. Therefore, genetic testing is particularly important in diverse populations. Unfortunately, all races and ethnic groups are not well represented in current genetic testing practices, leading to disparities in cancer prevention and early detection. PMID:27314195

  7. Pecan Street Grid Demonstration Program. Final technology performance report

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2015-02-10

    This document represents the final Regional Demonstration Project Technical Performance Report (TPR) for Pecan Street Inc.’s (Pecan Street) Smart Grid Demonstration Program, DE-OE-0000219. Pecan Street is a 501(c)(3) smart grid/clean energy research and development organization headquartered at The University of Texas at Austin (UT). Pecan Street worked in collaboration with Austin Energy, UT, Environmental Defense Fund (EDF), the City of Austin, the Austin Chamber of Commerce and selected consultants, contractors, and vendors to take a more detailed look at the energy load of residential and small commercial properties while the power industry is undergoing modernization. The Pecan Street Smart Grid Demonstration Program signed-up over 1,000 participants who are sharing their home or businesses’s electricity consumption data with the project via green button protocols, smart meters, and/or a home energy monitoring system (HEMS). Pecan Street completed the installation of HEMS in 750 homes and 25 commercial properties. The program provided incentives to increase the installed base of roof-top solar photovoltaic (PV) systems, plug-in electric vehicles with Level 2 charging, and smart appliances. Over 200 participants within a one square mile area took advantage of Austin Energy and Pecan Street’s joint PV incentive program and installed roof-top PV as part of this project. Of these homes, 69 purchased or leased an electric vehicle through Pecan Street’s PV rebate program and received a Level 2 charger from Pecan Street. Pecan Street studied the impacts of these technologies along with a variety of consumer behavior interventions, including pricing models, real-time feedback on energy use, incentive programs, and messaging, as well as the corresponding impacts on Austin Energy’s distribution assets.The primary demonstration site was the Mueller community in Austin, Texas. The Mueller development, located less than three miles from the Texas State Capitol

  8. Wabash River Coal Gasification Repowering Project: A DOE Assessment; FINAL

    International Nuclear Information System (INIS)

    The goal of the U.S. Department of Energy (DOE) Clean Coal Technology Program (CCT) is to furnish the energy marketplace with a number of advanced, more efficient, and environmentally responsible coal utilization technologies through demonstration projects. These projects seek to establish the commercial feasibility of the most promising advanced coal technologies that have developed beyond the proof-of-concept stage. This document serves as a DOE post-project assessment (PPA) of a project selected in CCT Round IV, the Wabash River Coal Gasification Repowering (WRCGR) Project, as described in a Report to Congress (U.S. Department of Energy 1992). Repowering consists of replacing an existing coal-fired boiler with one or more clean coal technologies to achieve significantly improved environmental performance. The desire to demonstrate utility repowering with a two-stage, pressurized, oxygen-blown, entrained-flow, integrated gasification combined-cycle (IGCC) system prompted Destec Energy, Inc., and PSI Energy, Inc., to form a joint venture and submit a proposal for this project. In July 1992, the Wabash River Coal Gasification Repowering Project Joint Venture (WRCGRPJV, the Participant) entered into a cooperative agreement with DOE to conduct this project. The project was sited at PSI Energy's Wabash River Generating Station, located in West Terre Haute, Indiana. The purpose of this CCT project was to demonstrate IGCC repowering using a Destec gasifier and to assess long-term reliability, availability, and maintainability of the system at a fully commercial scale. DOE provided 50 percent of the total project funding (for capital and operating costs during the demonstration period) of$438 million

  9. Decision Gate Process for Assessment of a NASA Technology Development Portfolio

    Science.gov (United States)

    Kohli, Rajiv; Fishman, Julianna L.; Hyatt, Mark J.

    2012-01-01

    The NASA Dust Management Project (DMP) was established to provide technologies (to Technology Readiness Level (TRL) 6) required to address adverse effects of lunar dust to humans and to exploration systems and equipment, to reduce life cycle cost and risk, and to increase the probability of sustainable and successful lunar missions. The technology portfolio of DMP consisted of different categories of technologies whose final product was either a technology solution in itself, or one that contributes toward a dust mitigation strategy for a particular application. A Decision Gate Process (DGP) was developed to assess and validate the achievement and priority of the dust mitigation technologies as the technologies progress through the development cycle. The DGP was part of continuous technology assessment and was a critical element of DMP risk management. At the core of the process were technology-specific criteria developed to measure the success of each DMP technology in attaining the technology readiness levels assigned to each decision gate. The DGP accounts for both categories of technologies and qualifies the technology progression from technology development tasks to application areas. The process provided opportunities to validate performance, as well as to identify non-performance in time to adjust resources and direction. This paper describes the overall philosophy of the DGP and the methodology for implementation for DMP, and describes the method for defining the technology evaluation criteria. The process is illustrated by example of an application to a specific DMP technology.

  10. Technology as an Assessment Tool in Language Learning

    OpenAIRE

    Taher Bahrani

    2011-01-01

    The present paper examines the employment of different technology-based tools such as computer, podcast, and chat for assessing language proficiency in EFL classrooms. These methods which are referred to as alternative assessments differ from traditional paper-and–pencil assessments. The technology-based assessment incorporates innovative methods and techniques to measure language proficiency improvement. This kind of assessment is effective when it gives the language learners a chance to use...

  11. Emerging Communication Technologies (ECT) Phase 3 Final Report

    Science.gov (United States)

    Bastin, Gary L.; Harris, William G.; Bates, Lakesha D.; Nelson, Richard A.

    2004-01-01

    The Emerging Communication Technology (ECT) project investigated three First Mile communication technologies in support of NASA s Second Generation Reusable Launch Vehicle (2nd Gen RLV), Orbital Space Plane, Advanced Range Technology Working Group (ARTWG) and the Advanced Spaceport Technology Working Group (ASTWG). These First Mile technologies have the purpose of interconnecting mobile users with existing Range Communication infrastructures. ECT was a continuation of the Range Information System Management (RISM) task started in 2002. RISM identified the three advance communication technologies investigated under ECT. These were Wireless Ethernet (Wi-Fi), Free Space Optics (FSO), and Ultra Wideband (UWB). Due to the report s size, it has been broken into three volumes: 1) Main Report 2) Appendices 3) UWB.

  12. A New Formative Assessment Technology for Reading and Writing

    Science.gov (United States)

    Landauer, Thomas K.; Lochbaum, Karen E.; Dooley, Scott

    2009-01-01

    Advances in assessment technologies are affording teachers and students new ways to efficiently assess and track achievement while also better promoting learning. WriteToLearn is one such technology, a Web-based tool that integrates practice and assessment in reading comprehension with writing about what is learned. Based on the principle of…

  13. Final report. CIRP seminar on micro and nano technology. November 2003

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard; Alting, Leo

    This final reports contains a description of the 1st international CIRP seminar on micro and nano technology held at DTU in November 2003.......This final reports contains a description of the 1st international CIRP seminar on micro and nano technology held at DTU in November 2003....

  14. Taiwan industrial cooperation program technology transfer for low-level radioactive waste final disposal - phase I.

    Energy Technology Data Exchange (ETDEWEB)

    Knowlton, Robert G.; Cochran, John Russell; Arnold, Bill Walter; Jow, Hong-Nian; Mattie, Patrick D.; Schelling, Frank Joseph Jr. (; .)

    2007-01-01

    Sandia National Laboratories and the Institute of Nuclear Energy Research, Taiwan have collaborated in a technology transfer program related to low-level radioactive waste (LLW) disposal in Taiwan. Phase I of this program included regulatory analysis of LLW final disposal, development of LLW disposal performance assessment capabilities, and preliminary performance assessments of two potential disposal sites. Performance objectives were based on regulations in Taiwan and comparisons to those in the United States. Probabilistic performance assessment models were constructed based on limited site data using software including GoldSim, BLT-MS, FEHM, and HELP. These software codes provided the probabilistic framework, container degradation, waste-form leaching, groundwater flow, radionuclide transport, and cover infiltration simulation capabilities in the performance assessment. Preliminary performance assessment analyses were conducted for a near-surface disposal system and a mined cavern disposal system at two representative sites in Taiwan. Results of example calculations indicate peak simulated concentrations to a receptor within a few hundred years of LLW disposal, primarily from highly soluble, non-sorbing radionuclides.

  15. Virtual Touch tissue quantification cannot assess breast cancer lesions except for ductal carcinomas in situ and small invasive cancers: a retrospective study

    OpenAIRE

    Tada, Keiichiro; Nishioka, Kotoe; Kikuchi, Yasuko; Niwa, Takayoshi; Seto, Yasuyuki

    2015-01-01

    Background Virtual Touch tissue quantification (VTTQ) is a promising new technology that quantitatively determines the stiffness of tissue. However, the clinical impact of this device on the assessment of breast cancer is unclear. Methods This study aimed to review the ultrasound records of patients with breast lesions where VTTQ was used to assess 123 normal breast tissues, 18 benign tumors, and 117 histopathologically confirmed breast cancers in a total of 129 patients. To determine the VTT...

  16. Accelerating cancer systems biology research through Semantic Web technology.

    Science.gov (United States)

    Wang, Zhihui; Sagotsky, Jonathan; Taylor, Thomas; Shironoshita, Patrick; Deisboeck, Thomas S

    2013-01-01

    Cancer systems biology is an interdisciplinary, rapidly expanding research field in which collaborations are a critical means to advance the field. Yet the prevalent database technologies often isolate data rather than making it easily accessible. The Semantic Web has the potential to help facilitate web-based collaborative cancer research by presenting data in a manner that is self-descriptive, human and machine readable, and easily sharable. We have created a semantically linked online Digital Model Repository (DMR) for storing, managing, executing, annotating, and sharing computational cancer models. Within the DMR, distributed, multidisciplinary, and inter-organizational teams can collaborate on projects, without forfeiting intellectual property. This is achieved by the introduction of a new stakeholder to the collaboration workflow, the institutional licensing officer, part of the Technology Transfer Office. Furthermore, the DMR has achieved silver level compatibility with the National Cancer Institute's caBIG, so users can interact with the DMR not only through a web browser but also through a semantically annotated and secure web service. We also discuss the technology behind the DMR leveraging the Semantic Web, ontologies, and grid computing to provide secure inter-institutional collaboration on cancer modeling projects, online grid-based execution of shared models, and the collaboration workflow protecting researchers' intellectual property. PMID:23188758

  17. Screening Technologies for Target Identification in Pancreatic Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Michl, Patrick, E-mail: michlp@med.uni-marburg.de; Ripka, Stefanie; Gress, Thomas; Buchholz, Malte [Department of Gastroenterology and Endocrinology, University Hospital, Philipps-University Marburg, Baldinger Strasse, D-35043 Marburg (Germany)

    2010-12-29

    Pancreatic cancer exhibits an extraordinarily high level of resistance to almost any kind of systemic therapy evaluated in clinical trials so far. Therefore, the identification of novel therapeutic targets is urgently required. High-throughput screens have emerged as an important tool to identify putative targets for diagnosis and therapy in an unbiased manner. More than a decade ago, microarray technology was introduced to identify differentially expressed genes in pancreatic cancer as compared to normal pancreas, chronic pancreatitis and other cancer types located in close proximity to the pancreas. In addition, proteomic screens have facilitated the identification of differentially secreted proteins in body fluids of pancreatic cancer patients, serving as possible biomarkers. Recently, RNA interference-based loss-of-function screens have been used to identify functionally relevant genes, whose knock-down has impact on pancreatic cancer cell viability, thereby representing potential new targets for therapeutic intervention. This review summarizes recent results of transcriptional, proteomic and functional screens in pancreatic cancer and discusses potentials and limitations of the respective technologies as well as their impact on future therapeutic developments.

  18. Screening Technologies for Target Identification in Pancreatic Cancer

    International Nuclear Information System (INIS)

    Pancreatic cancer exhibits an extraordinarily high level of resistance to almost any kind of systemic therapy evaluated in clinical trials so far. Therefore, the identification of novel therapeutic targets is urgently required. High-throughput screens have emerged as an important tool to identify putative targets for diagnosis and therapy in an unbiased manner. More than a decade ago, microarray technology was introduced to identify differentially expressed genes in pancreatic cancer as compared to normal pancreas, chronic pancreatitis and other cancer types located in close proximity to the pancreas. In addition, proteomic screens have facilitated the identification of differentially secreted proteins in body fluids of pancreatic cancer patients, serving as possible biomarkers. Recently, RNA interference-based loss-of-function screens have been used to identify functionally relevant genes, whose knock-down has impact on pancreatic cancer cell viability, thereby representing potential new targets for therapeutic intervention. This review summarizes recent results of transcriptional, proteomic and functional screens in pancreatic cancer and discusses potentials and limitations of the respective technologies as well as their impact on future therapeutic developments

  19. Technological advances in radiotherapy of rectal cancer

    DEFF Research Database (Denmark)

    Appelt, Ane L; Sebag-Montefiore, David

    2016-01-01

    , selective sparing of specific organs to enable chemotherapy escalation, and nonsurgical management. SUMMARY: Few prospective studies of IMRT and VMAT exist, which causes uncertainty not just in regards to the clinical benefit of these technologies but also in the optimal use. The priority for future...

  20. Evolution of cancer risk assessment and counseling related to psychological, financial and legal implications.

    Science.gov (United States)

    Snyder, Carrie

    2016-07-01

    Cancer risk assessment, genetic counseling and genetic testing have experienced advances and changes over the past two decades due to improved technology, legal movements to protect those at an increased risk for cancer due to genetics, as well as advances in detection, prevention and treatment. This brief article will provide a summary of these advances over three eras of cancer genetics: pre-discovery of the more common high impact genes, namely BRCA1/BRCA2 and the mismatch repair genes associated with Lynch syndrome; the time during which the genes were being discovered; and current day. PMID:26920353

  1. GENE TECHNOLOGY: A NEW WAY TO TREAT CANCER

    Directory of Open Access Journals (Sweden)

    Prajapati P M.

    2012-06-01

    Full Text Available Gene therapy is the process of introducing genetic material RNA or DNA into a person's cells to fight disease. Gene therapy treats disease by either replacing damaged or missing genes with normal ones, or by providing new genes. The concept of gene therapy was born more than thirty years ago; however, new technology is opening the door to dramatically new possibilities in the treatment of cancers of all kinds. The long-term goal of cancer gene therapy is to develop treatments that attack only cancer cells, thereby eliminating adverse effects on the body and improving the possibility to cure disease. Gene therapy may someday soon make cancer a manageable disease with nominal side effects to the patients. Furthermore, since gene therapy has potential for other diseases such as cystic fibrosis, hemophilia, sickle-cell anemia, muscular dystrophy and Parkinson's, the value of research and discovery has broad applications.

  2. Cancer Stem Cells: The Final Frontier for Glioma Virotherapy

    OpenAIRE

    Dey, Mahua; Ulasov, Ilya V.; Tyler, Matthew A.; Sonabend, Adam M.; Lesniak, Maciej S.

    2011-01-01

    Cancer stem cells (CSC) are a very small subset of all cancer cells and possess characteristics very similar to normal stem cells, in particular, the capacity for self-renewal, multipotency and relative quiescence. These chemo- and radiation resistant cells are responsible for maintaining tumor volume leading to therapy failure and recurrence. In glioblastoma multiforme (GBM), the most common primary intracranial malignancy, glioma stem cells have been implicated as one of the key players in ...

  3. Problems of method of technology assessment

    International Nuclear Information System (INIS)

    The study undertakes to analyse the theoretical and methodological structure of Technology Assessment (TA). It is based on a survey of TA studies which provided an important condition for theoreticall sound statements on methodological aspects of TA. It was established that the main basic theoretical problems of TA are in the field of dealing with complexity. This is also apparent in the constitution of problems, the most elementary and central approach of TA. Scientifically founded constitution of problems and the corresponding construction of models call for interdisciplinary scientific work. Interdisciplinarity in the TA research process is achieved at the level of virtual networks, these networks being composed of individuals suited to teamwork. The emerging network structures have an objective-organizational and an ideational basis. The objective-organizational basis is mainly the result of team composition and the external affiliations of the team members. The ideational basis of the virtual network is represented by the team members' mode of thinking, which is individually located at a multidisciplinary level. The theoretical 'skeleton' of the TA knowledge system, which is represented by process knowledge based linkage structures, can be generated and also processed in connection with the knowledge on types of problems, areas of analysis and procedures to deal with complexity. Within this process, disciplinary knowledge is a necessary but not a sufficient condition. Metatheoretical and metadisciplinary knowledge and the correspondingly processes complexity of models are the basis for the necessary methodological awareness, that allows TA to become designable as a research procedure. (orig./HP)

  4. Environmental assessment report: Nuclear Test Technology Complex

    International Nuclear Information System (INIS)

    The US Department of Energy (USDOE) is planning to construct and operate a structure, designated the Nuclear Test Technology Complex (NTTC), on a site located west of and adjacent to the Lawrence Livermore National Laboratory. The NTTC is designed to house 350 nuclear test program personnel, and will accommodate the needs of the entire staff of the continuing Nuclear Test Program (NTP). The project has three phases: land acquisition, facility construction and facility operation. The purpose of this environmental assessment report is to describe the activities associated with the three phases of the NTTC project and to evaluate potential environmental disruptions. The project site is located in a rural area of southeastern Alameda County, California, where the primary land use is agriculture; however, the County has zoned the area for industrial development. The environmental impacts of the project include surface disturbance, high noise levels, possible increases in site erosion, and decreased air quality. These impacts will occur primarily during the construction phase of the NTTC project and can be mitigated in part by measures proposed in this report

  5. Establishing a family risk assessment clinic for breast cancer.

    LENUS (Irish Health Repository)

    Mulsow, Jurgen

    2012-02-01

    Breast cancer is the most common cancer affecting European women and the leading cause of cancer-related death. A total of 15-20% of women who develop breast cancer have a family history and 5-10% a true genetic predisposition. The identification and screening of women at increased risk may allow early detection of breast cancer and improve prognosis. We established a family risk assessment clinic in May 2005 to assess and counsel women with a family history of breast cancer, to initiate surveillance, and to offer risk-reducing strategies for selected high-risk patients. Patients at medium or high risk of developing breast cancer according to NICE guidelines were accepted. Family history was determined by structured questionnaire and interview. Lifetime risk of developing breast cancer was calculated using Claus and Tyrer-Cuzick scoring. Risk of carrying a breast cancer-related gene mutation was calculated using the Manchester system. One thousand two hundred and forty-three patients have been referred. Ninety-two percent were at medium or high risk of developing breast cancer. Formal assessment of risk has been performed in 368 patients, 73% have a high lifetime risk of developing breast cancer, and 72% a Manchester score >or=16. BRCA1\\/2 mutations have been identified in 14 patients and breast cancer diagnosed in two. Our initial experience of family risk assessment has shown there to be a significant demand for this service. Identification of patients at increased risk of developing breast cancer allows us to provide individuals with accurate risk profiles, and enables patients to make informed choices regarding their follow-up and management.

  6. INNOVATIVE FOSSIL FUEL FIRED VITRIFICATION TECHNOLOGY FOR SOIL REMEDIATION. FINAL REPORT

    International Nuclear Information System (INIS)

    This Final Report summarizes the progress of Phases 3,3A and 4 of a waste technology Demonstration Project sponsored under a DOE Environmental Management Research and Development Program and administered by the U.S. Department of Energy National Energy Technology Laboratory-Morgantown (DOE-NETL) for an ''Innovative Fossil Fuel Fired Vitrification Technology for Soil Remediation''. The Summary Reports for Phases 1 and 2 of the Program were previously submitted to DOE. The total scope of Phase 3 was to have included the design, construction and demonstration of Vortec's integrated waste pretreatment and vitrification process for the treatment of low level waste (LLW), TSCA/LLW and mixed low-level waste (MLLW). Due to funding limitations and delays in the project resulting from a law suit filed by an environmental activist and the extended time for DOE to complete an Environmental Assessment for the project, the scope of the project was reduced to completing the design, construction and testing of the front end of the process which consists of the Material Handling and Waste Conditioning (MH/C) Subsystem of the vitrification plant. Activities completed under Phases 3A and 4 addressed completion of the engineering, design and documentation of the MH/C System such that final procurement of the remaining process assemblies can be completed and construction of a Limited Demonstration Project be initiated in the event DOE elects to proceed with the construction and demonstration testing of the MH/C Subsystem. Because of USEPA policies and regulations that do not require treatment of low level or low-level/PCB contaminated wastes, DOE terminated the project because there is no purported need for this technology

  7. Advanced Thermionic Technology Program: summary report. Volume 2. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1984-10-01

    This report summarizes the progress made by the Advanced Thermionic Technology Program during the past several years. This Program, sponsored by the US Department of Energy, has had as its goal adapting thermionic devices to generate electricity in a terrestrial (i.e., combustion) environment. The technology has previously been developed for astronautical applications. Volume 2 (Part C) concentrates on the progress made in developing and fabricating the ''current generation'' of chemical vapor deposited hot shell thermionic converters and is addressed to those primarily concerned with today's capabilities in terrestrial thermionic technology. 30 refs., 83 figs.

  8. Polyethylene encapsulation full-scale technology demonstration. Final report

    International Nuclear Information System (INIS)

    A full-scale integrated technology demonstration of a polyethylene encapsulation process, sponsored by the US Department of Energy (DOE) Office of Technology Development (OTD), was conducted at the Environmental ampersand Waste Technology Center at Brookhaven National Laboratory (BNL.) in September 1994. As part of the Polymer Solidification National Effort, polyethylene encapsulation has been developed and tested at BNL as an alternative solidification technology for improved, cost-effective treatment of low-level radioactive (LLW), hazardous and mixed wastes. A fully equipped production-scale system, capable of processing 900 kg/hr (2000 lb/hr), has been installed at BNL. The demonstration covered all facets of the integrated processing system including pre-treatment of aqueous wastes, precise feed metering, extrusion processing, on-line quality control monitoring, and process control

  9. UK Coal resource for new exploitation technologies. Final report

    OpenAIRE

    Jones, N. S.; Holloway, S.; Creedy, D.P.; Gamer, K.; Smith, N.J.P.; Browne, M.A.E.; S. Durucan

    2004-01-01

    This focus of this report are the UK coal resources available for exploitation by the new technologies of Underground Coal Gasification, Coalbed Methane production and Carbon Dioxide Sequestration. It also briefly considers the potential for further underground and opencast mining and the extraction of methane from working and closed mines. The potential for mining was mainly considered because it has a bearing on the scope for the new exploitation technologies rather than to identify resourc...

  10. DOE SNF technology development necessary for final disposal

    International Nuclear Information System (INIS)

    Existing technology is inadequate to allow safe disposal of the entire inventory of US Department of Energy (DOE) spent nuclear fuel (SNF). Needs for SNF technology development were identified for each individual fuel type in the diverse inventory of SNF generated by past, current, and future DOE materials production, as well as SNF returned from domestic and foreign research reactors. This inventory consists of 259 fuel types with different matrices, cladding materials, meat composition, actinide content, and burnup. Management options for disposal of SNF include direct repository disposal, possible including some physical or chemical preparation, or processing to produce a qualified waste form by using existing aqueous processes or new treatment processes. Technology development needed for direct disposal includes drying, mitigating radionuclide release, canning, stabilization, and characterization technologies. While existing aqueous processing technology is fairly mature, technology development may be needed to apply one of these processes to SNF different than for which the process was originally developed. New processes to treat SNF not suitable for disposal in its current form were identified. These processes have several advantages over existing aqueous processes

  11. Development of integrated assessment technology for risk and performance

    International Nuclear Information System (INIS)

    The main idea and contents are summarized as below - Development of new risk/performance assessment system innovating old labor-intensive risk assessment structure · New consolidated risk assessment technology from various hazard(flood, fire, seismic) in NPP Consolidated risk/performance management system for consistency and efficiency of NPP Development of the risk-informed severe accident management supporting system - Resolution technology for pending issues in Pasa Basic technology for Pasa of digital I and C system Basic technology for seismic Pasa reflecting domestic seismic characteristics and aging effect Uncertainty reduction technology for level 2 Pasa and best estimation of containment failure frequency - Assessment technology for new emerging risk/performance issues Human-induced error reduction technology for efficient operation of a NPP B/P model development for performance monitoring

  12. Development of Integrated Assessment Technology of Risk and Performance

    International Nuclear Information System (INIS)

    The main idea and contents are summarized as below 1) Development of new risk/performance assessment system innovating old labor-intensive risk assessment structure - New consolidated risk assessment technology from various hazard(flood, fire, seismic in NPP) - BOP model development for performance monitoring - Consolidated risk/performance management system for consistency and efficiency of NPP 2) Resolution technology for pending issues in PSA - Base technology for PSA of digital I and C system - Base technology for seismic PSA reflecting domestic seismic characteristics and aging effect - Uncertainty reduction technology for level 2 PSA and best estimation of containment failure frequency 3) Next generation risk/performance assessment technology - Human-induced error reduction technology for efficient operation of a NPP

  13. Zebrafish as a model to assess cancer heterogeneity, progression and relapse

    Directory of Open Access Journals (Sweden)

    Jessica S. Blackburn

    2014-07-01

    Full Text Available Clonal evolution is the process by which genetic and epigenetic diversity is created within malignant tumor cells. This process culminates in a heterogeneous tumor, consisting of multiple subpopulations of cancer cells that often do not contain the same underlying mutations. Continuous selective pressure permits outgrowth of clones that harbor lesions that are capable of enhancing disease progression, including those that contribute to therapy resistance, metastasis and relapse. Clonal evolution and the resulting intratumoral heterogeneity pose a substantial challenge to biomarker identification, personalized cancer therapies and the discovery of underlying driver mutations in cancer. The purpose of this Review is to highlight the unique strengths of zebrafish cancer models in assessing the roles that intratumoral heterogeneity and clonal evolution play in cancer, including transgenesis, imaging technologies, high-throughput cell transplantation approaches and in vivo single-cell functional assays.

  14. Nutritional status assessment in colorectal cancer patients

    OpenAIRE

    Joana Pedro Lopes; Paula Manuela de Castro Cardoso Pereira; Ana Filipa dos Reis Baltazar Vicente; Alexandra Bernardo; María Fernanda de Mesquita

    2013-01-01

    The present study intended to evaluate the nutritional status of Portuguese colorectal patients and associated it with surgery type as well as quality of life outcomes. Malnutrition can affect up to 85% of cancer patients and specifically 30-60% in colorectal cancer and can significantly influence health outcomes. A sample of 50 colorectal cancer patients was evaluated in what refers to several anthropometric measures, food intake, clinical history, complications rate before and after surgery...

  15. Technical and economic assessment of solar hybrid repowering. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-09-01

    Public Service Company of New Mexico (PNM) has performed a Technical and Economic Assessment of Solar Hybrid Repowering under funding by the Department of Energy (DOE), the Electric Power Research Institute (EPRI), Western Energy Supply and Transmission (WEST) Associates, and a number of southwestern utilities. Solar hybrid repowering involves placement of solar hardware adjacent to and connected to existing gas- and oil-fueled electric generation units to displace some of or all the fossil fuel normally used during daylight hours. The subject study assesses the technical economic viability of the solar hybrid repowering concept within the southwestern United States and the PNM system. This document is a final report on the study and its results. The study was divided into the six primary tasks to allow a systematic investigation of the concept: (1) market survey and cost/benefit analysis, (2) study unit selection, (3) conceptual design and cost estimates, (4) unit economic analysis, (5) program planning, future phases, and (6) program management. Reeves Station No. 2 at Albuquerque, New Mexico, was selected for repowering with a design goal of 50 percent (25 MWe). The solar system design is based on the 10 MW solar central receiver pilot plant preliminary design for Barstow, California. SAN--1608-4-2 contains the technical drawings. (WHK)

  16. Flammability Assessment Methodology Program Phase I: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    C. A. Loehr; S. M. Djordjevic; K. J. Liekhus; M. J. Connolly

    1997-09-01

    The Flammability Assessment Methodology Program (FAMP) was established to investigate the flammability of gas mixtures found in transuranic (TRU) waste containers. The FAMP results provide a basis for increasing the permissible concentrations of flammable volatile organic compounds (VOCs) in TRU waste containers. The FAMP results will be used to modify the ''Safety Analysis Report for the TRUPACT-II Shipping Package'' (TRUPACT-II SARP) upon acceptance of the methodology by the Nuclear Regulatory Commission. Implementation of the methodology would substantially increase the number of drums that can be shipped to the Waste Isolation Pilot Plant (WIPP) without repackaging or treatment. Central to the program was experimental testing and modeling to predict the gas mixture lower explosive limit (MLEL) of gases observed in TRU waste containers. The experimental data supported selection of an MLEL model that was used in constructing screening limits for flammable VOC and flammable gas concentrations. The MLEL values predicted by the model for individual drums will be utilized to assess flammability for drums that do not meet the screening criteria. Finally, the predicted MLEL values will be used to derive acceptable gas generation rates, decay heat limits, and aspiration time requirements for drums that do not pass the screening limits. The results of the program demonstrate that an increased number of waste containers can be shipped to WIPP within the flammability safety envelope established in the TRUPACT-II SARP.

  17. Advanced Thermionic Technology Program: summary report. Volume 3. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1984-10-01

    This report summarizes the progress made by the Advanced Thermionic Technology Program during the past several years. This Program, sponsored by the US Department of Energy, has had as its goal adapting thermionic devices to generate electricity in a terrestrial (i.e., combustion) environment. Volume 3 (Part D) contains the results of systems studies of primary interest to those involved in identifying and evaluating applications for thermionics. As a general rule of thumb, cogeneration technologies are most attractive to industries when those technologies naturally produce a ration of electrical to thermal output which closely matches the demand within the industrial facilities themselves. Several of the industries which consume the largest amounts of energy have an electrical-to-thermal ratio of about ten percent, as can be seen in Exhibit D-1.1. This closely matches the electrical efficiency of thermionic converters. Thermionic cogeneration has several other unique advantages relative to alternative technologies for cogeneration which should lead to a much broader application of cogeneration in industry. These advantages accrue from the much higher temperatures at which thermionic energy conversion takes place, its suitability for very small as well as large process heaters, and, of course, its production of direct heat rather than process steam. In fact, thermionics can even be coupled to more conventional cogeneration technologies (e.g., steam turbines) to extend their applicability to processes requiring a greater electrical-to-thermal ratio than either cogeneration technology alone can provide. Several examples of thermionic cogeneration are presented in greater detail: copper refining by the Noranda process; thermionic topping cycles for gas turbine; and combined cycle and fossil-fuel steam power plants. 13 refs., 71 figs.

  18. INL Control System Situational Awareness Technology Final Report 2013

    Energy Technology Data Exchange (ETDEWEB)

    Gordon Rueff; Bryce Wheeler; Todd Vollmer; Tim McJunkin

    2013-01-01

    The Situational Awareness project is a comprehensive undertaking of Idaho National Laboratory (INL) in an effort to produce technologies capable of defending the country’s energy sector infrastructure from cyber attack. INL has addressed this challenge through research and development of an interoperable suite of tools that safeguard critical energy sector infrastructure. The technologies in this project include the Sophia Tool, Mesh Mapper (MM) Tool, Intelligent Cyber Sensor (ICS) Tool, and Data Fusion Tool (DFT). Each is designed to function effectively on its own, or they can be integrated in a variety of customized configurations based on the end user’s risk profile and security needs.

  19. Appalachian Rivers II Conference: Technology for Monitoring, Assessing, and Restoring Streams, Rivers, and Watersheds

    Energy Technology Data Exchange (ETDEWEB)

    None available

    1999-07-29

    On July 28-29, 1999, the Federal Energy Technology Center (FETC) and the WMAC Foundation co-sponsored the Appalachian Rivers II Conference in Morgantown, West Virginia. This meeting brought together over 100 manufacturers, researchers, academicians, government agency representatives, watershed stewards, and administrators to examine technologies related to watershed assessment, monitoring, and restoration. Sessions included presentations and panel discussions concerning watershed analysis and modeling, decision-making considerations, and emerging technologies. The final session examined remediation and mitigation technologies to expedite the preservation of watershed ecosystems.

  20. Cast Metals Coalition Technology Transfer and Program Management Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Gwyn, Mike

    2009-03-31

    The Cast Metals Coalition (CMC) partnership program was funded to ensure that the results of the Department of Energy's (DOE) metalcasting research and development (R&D) projects are successfully deployed into industry. Specifically, the CMC program coordinated the transfer and deployment of energy saving technologies and process improvements developed under separately funded DOE programs and projects into industry. The transition of these technologies and process improvements is a critical step in the path to realizing actual energy savings. At full deployment, DOE funded metalcasting R&D results are projected to save 55% of the energy used by the industry in 1998. This closely aligns with DOE's current goal of driving a 25% reduction in industrial energy intensity by 2017. In addition to benefiting DOE, these energy savings provide metalcasters with a significant economic advantage. Deployment of already completed R&D project results and those still underway is estimated to return over 500% of the original DOE and industry investment. Energy savings estimates through December 2008 from the Energy-Saving Melting and Revert Reduction Technology (E-SMARRT) portfolio of projects alone are 12 x 1012 BTUs, with a projection of over 50 x 1012 BTUs ten years after program completion. These energy savings and process improvements have been made possible through the unique collaborative structure of the CMC partnership. The CMC team consists of DOE's Office of Industrial Technology, the three leading metalcasting technical societies in the U.S: the American Foundry Society; the North American Die Casting Association; and the Steel Founders Society of America; and the Advanced Technology Institute (ATI), a recognized leader in distributed technology management. CMC provides collaborative leadership to a complex industry composed of approximately 2,100 companies, 80% of which employ less than 100 people, and only 4% of which employ more than 250 people

  1. Technology in military strategy: a realistic assessment

    Energy Technology Data Exchange (ETDEWEB)

    Sanders, R.

    1983-01-01

    Today the Military Reform Movement strongly criticizes the United States military for being mesmerized by technology to the detriment of other, including human, factors. Only in this century have writers given great attention to war technologies. In contrast to strategic thinkers like Sun-Tsu, Machiavelli, Clausewitz, Moltke, and Mahan, post-World War I theorists like fuller, Liddell Hart, Douhet, and Mitchell made technology a key to their strategic concepts. Nuclear war theorists like Brodie, Kahn, and Wohlstetter made technology a centrality, while limited war theorists like Osgood and Kissinger gave it considerable, but less, stress. The reformers place more weight on teh art of using military forces than on weapons, emphasizing mobility and historical lessons, rather than technology. Nuclear war theories rely too heavily on technological dimensions to expect a shift. Somewhat more attention could profitably be paid to nontechnological aspects of conventional war, but any violent pendulum swing should be avoided.

  2. Electro-Optical Laser Technology. Curriculum Utilization. Final Report.

    Science.gov (United States)

    Nawn, John H.

    This report describes a program to prepare students for employment as laser technicians and laser operators and to ensure that they have the necessary skills required by the industry. The objectives are to prepare a curriculum and syllabus for an associate degree program in Electro-Optical Laser Technology. The 2-year Electro-Optical Laser program…

  3. Test and evaluation of item control technology. Final report

    International Nuclear Information System (INIS)

    A brief summary is given of the work carried out on Task 3 at the IPPE's BFS facility in Obninsk, Russia. Methods and concepts of Item Control Technology from LANL and SNL were examined. At BFS the nuclear material accounting items are plutonium and highly enriched uranium disks. Work was done on identification techniques and safeguards for these materials

  4. Final Report on HOLODEC 2 Technology Readiness Level

    Energy Technology Data Exchange (ETDEWEB)

    Shaw, RA; Spuler, SM; Beals, M; Black, N; Fugal, JP; Lu, L

    2012-06-18

    During the period of this project, the Holographic Detector for Clouds 2 (HOLODEC 2) instrument has advanced from a laboratory-proven instrument with some initial field testing to a fully flight-tested instrument capable of providing useful cloud microphysics measurements. This can be summarized as 'Technology Readiness Level 8: Technology is proven to work - Actual technology completed and qualified through test and demonstration.' As part of this project, improvements and upgrades have been made to the optical system, the instrument power control system, the data acquisition computer, the instrument control software, the data reconstruction and analysis software, and some of the basic algorithms for estimating basic microphysical variables like droplet diameter. Near the end of the project, the instrument flew on several research flights as part of the IDEAS 2011 project, and a small sample of data from the project is included as an example. There is one caveat in the technology readiness level stated above: the upgrades to the instrument power system were made after the flight testing, so they are not fully field proven. We anticipate that there will be an opportunity to fly the instrument as part of the IDEAS project in fall 2012.

  5. Integrated System Health Management (ISHM) Technology Demonstration Project Final Report

    Science.gov (United States)

    Mackey, Ryan; Iverson, David; Pisanich, Greg; Toberman, Mike; Hicks, Ken

    2006-01-01

    Integrated System Health Management (ISHM) is an essential capability that will be required to enable upcoming explorations mission systems such as the Crew Exploration Vehicle (CEV) and Crew Launch Vehicle (CLV), as well as NASA aeronautics missions. However, the lack of flight experience and available test platforms have held back the infusion by NASA Ames Research Center (ARC) and the Jet Propulsion Laboratory (JPL) of ISHM technologies into future space and aeronautical missions. To address this problem, a pioneer project was conceived to use a high-performance aircraft as a low-cost proxy to develop, mature, and verify the effectiveness of candidate ISHM technologies. Given the similarities between spacecraft and aircraft, an F/A-18 currently stationed at Dryden Flight Research Center (DFRC) was chosen as a suitable host platform for the test bed. This report describes how the test bed was conceived, how the technologies were integrated on to the aircraft, and how these technologies were matured during the project. It also describes the lessons learned during the project and a forward path for continued work.

  6. Assessments of emerging science and technologies: Mapping the landscape

    NARCIS (Netherlands)

    Forsberg, E.M.; Thorstensen, E.; Nielsen, R.O.; Bakker, de E.

    2014-01-01

    This paper presents comparative work from the EST-Frame project on technology appraisal. It focuses on studies of 'advisory domains' (more or less distinct traditions for assessment of technologies, such as risk analysis, foresight and ethical assessments). The purpose of the study was to increase t

  7. Technical analysis of US Army Weapons Systems and related advanced technologies of military interest. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1991-06-14

    This report summarizes the activities and accomplishments of an US Army technology security project designed to identify and develop effective policy guidelines for militarily critical technologies in specific Army systems and in broad generic technology areas of military interest, Individual systems analyses are documented in separate Weapons Systems Technical Assessments (WSTAs) and the general generic technology areas are evaluated in the Advanced Technology Assessment Reports (ATARs), However, specific details of these assessments are not addressed here, only recommendations regarding aspects of the defined approach, methodology, and format are provided and discussed.

  8. Predicting technology operational availability using technical maturity assessment

    International Nuclear Information System (INIS)

    A technical maturity assessment method was performed by systems engineers in collaboration with an advisory panel composed of team members from different Department of Energy sites and from different engineering and science disciplines. Various stabilization technologies were assessed annually as to their relative maturity and availability for use in stabilizing nuclear materials. After three years of assessments, several of the technologies are now components of operational systems. A regression analysis of the historical assessments was performed, and it was concluded that the numerical technical maturity score produced by a team of experts can provide a powerful predictor of the time remaining until the operational application of technologies

  9. Technology review of commercial food service equipment - final report

    Energy Technology Data Exchange (ETDEWEB)

    Rahbar, S.; Krsikapa, S. [Canadian Gas Research Inst., Don Mills, ON (Canada); Fisher, D.; Nickel, J.; Ardley, S.; Zabrowski, D. [Fisher Consultants (Canada); Barker, R.F. [ed.

    1996-05-15

    Technical information on commercial gas cooking appliances was presented. This second volume provided an appliance-by-appliance comprehensive assessment of the energy performance of commercial food service equipment. Energy assessments were made for the following categories of cooking equipment: fryers, griddles, broilers, ranges, Chinese ranges, ovens, steamers, steam kettles, and braising pans. Recommendations were made for improving the energy efficiency and overall performance of gas appliances to support of the Canadian gas utilities marketing and energy conservation initiatives. 71 refs., 37 tabs., 58 figs.

  10. Accelerating the deployment of offshore renewable energy technologies. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    MacDonald, Mott

    2011-02-15

    Offshore wind energy and ocean energy (i.e. wave and tidal) are at different stages of technology development and deployment, and, as such, they require different approaches for successful deployment. However, regardless of their deployment stage, these technologies may face common hurdles in their way to market competitiveness. IEA-RETD has completed a study with the overall objective to assist policy makers and project developers in a better understanding of these barriers and the specifics of offshore renewable energy and to give them practical guidelines. These include an offshore energy deployment framework, substantiated by evidence-based analyses, and recommendations for future policies design, including best practices for allocation of seafloor rights.

  11. The final technical report of the CRADA, 'Medical Accelerator Technology'

    International Nuclear Information System (INIS)

    Under this CRADA, Berkeley Lab and the industry partner, General Atomics (GA), have cooperatively developed hadron therapy technologies for commercialization. Specifically, Berkeley Lab and GA jointly developed beam transport systems to bring the extracted protons from the accelerator to the treatment rooms, rotating gantries to aim the treatment beams precisely into patients from any angle, and patient positioners to align the patient accurately relative to the treatment beams. We have also jointly developed a patient treatment delivery system that controls the radiation doses in the patient, and hardware to improve the accelerator performances, including a radio-frequency ion source and its low-energy beam transport (LEBT) system. This project facilitated the commercialization of the DOE-developed technologies in hadron therapy by the private sector in order to improve the quality of life of the nation

  12. Diffusion of energy-efficient technologies in industry. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Hsu, S.Y.

    1979-01-01

    United States energy policies aim at cutting down dependence on foreign oil in two ways: by energy conservation and by finding new domestic supplies. The study investigates how the first goal can be achieved in the industrial sector (manufacturing) of the economy, which accounts for about 40% (about 7.3 million barrels per day) of the total energy consumption in the US. It is noted that industry is able to conserve as much as 25 to 30% of its energy consumption by adopting simple conservation measures and energy-efficient technologies. These technologies can be implemented without major alterations of the original equipment. The schools of thought on innovative processes are discussed; these will serve as the conceptual and methodological base of the project. (MCW)

  13. Termo technology programme. Final report 1993-1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-31

    The TERMO-technology programme was realised in 1993-1997. The aim of the programme was to promote the profitability and sustainable development of district heating by means of research and development actions. The programme included 36 research projects that were distributed to four research areas. These included heat distribution, metering, information and control systems, the economy of district heating as well as system development. The costs totaled to FIM 12 million. The programme was financed by the participating companies and the Technology Development Centre TEKES. Around eighty Finnish companies and institutions participated in the programme. In addition, the programme participated in international research cooperation in the framework of the Nordic Council of Ministers and the International Energy Agency programmes. The research area Heat Distribution included projects on rehabilitation and status control of district heating networks, pumping, thermal stresses in district heating pipes, material questions, water treatment, steam pipe systems as well as drag reducing additives in district heating water. The research area Metering, Information and Control Systems included projects on forecasts of district heating load, calibration of flow meters, heat cost allocation in buildings, control systems and their qualifications in buildings and improved cooling of district heating water in the consumer equipment. The research area Economy included projects on determination of subscribed heat demand, pricing methods of district heating, success factors of energy companies as well as long term prospects of district heating in Finland. The research area System Development included projects on changing heat loads, district cooling as well as combined heat and power production. After the TERMO programme joint efforts will be continued for the development of district heating technology. The emphasis will be to improve the feasibility of combined heat and power

  14. Flexible Assembly Solar Technology (FAST) Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Toister, Elad [BrightSource Energy Inc., Jerusalem (Israel)

    2014-11-06

    The Flexible Assembly Solar Technology (FAST) project was initiated by BrightSource in an attempt to provide potential solar field EPC contractors with an effective set of tools to perform specific construction tasks. These tasks are mostly associated with heliostat assembly and installation, and require customized non-standard tools. The FAST concept focuses on low equipment cost, reduced setup time and increased assembly throughput as compared to the Ivanpah solar field construction tools.

  15. A critical assessment of fuel cell technology

    International Nuclear Information System (INIS)

    Cold combustion is a promised technology to mankind since the middle of the last century. The fuel cell may at last become the energy machine of the one to come after a long journey on a road bordered with expectations, successes and disappointments. Ten billion people will need the cell for their well-being. The progress and the state-of-art is assessed by means of figures of merit for performance, normalized to standard conditions, life and variability. State-of-art current densities for multi-kW stacks operating on atmospheric pressure air at 0.74 V cell voltage (50% efficiency, HHV) are estimated to be 150 mA/cm2 for MCFC, 160 mA/cm2 for AFC, 239 mA/cm2 for PEFC and 270 mA/cm2 for SOFC. PAFC gives 260 mA/cm2 at 0.66 V and DMFC 100 mA/cm2 at 0.37 V. Decay rates are about 1%/1000 h for PEFC, PAFC and SOFC compared to 2%/1000 h for AFC and 3%/1000 h for MCFC. Coefficients of variation for cell voltages amount to about 1% for all options, except for MCFC with 3-4%. Improvement of cell performance after 1975 is nil to moderate, except for SOFC with a consistent annual improvement of about 10%. There is room for further development of terrestrial AFCs towards 300-400 mA/cm2 considering the figure 800 mA/cm2 for oxygen AFCs. Life and cost will decide the future of the fuel cell. Prospects are not as good as they could be. The fuel cell community lacks understanding of the basics of fuel processing, as demonstrated by the widespread misbelief ('the CO2 syndrome') that CO2 cannot be removed cost effectively from a hydrogen feed (which is practiced in every NH3 plant around the world). The competition, read the gas turbine, has to be taken very seriously. Emphasis has to be shifted from premature demonstrations to R and D on fundamental problems, which have been around too long. 34 refs

  16. The psychosocial oncology learning assessment: a province-wide survey of cancer care providers' learning needs.

    Science.gov (United States)

    Rennie, Heather; Mackenzie, Gina

    2010-06-01

    A psychosocial oncology learning needs assessment was developed and offered online to cancer care providers in a variety of settings across all health regions in British Columbia. The purpose was to better understand the psychosocial learning needs of cancer care providers and to use this knowledge to shape continuing education priorities. Respondents' preferred learning formats, access to technology and barriers to accessing psychosocial learning opportunities were also assessed. Cancer care providers including radiation therapists, social workers, dieticians, pharmacists, physicians and nurses in both community and agency settings were surveyed. Two hundred and sixty-seven people completed the survey. Key learning needs identified included cultural aspects of care, symptom management, treating the anxious patient, self-care for the professional, care of elderly patients, basic cancer-related medical issues surrounding care and ethics. Community respondents indicated more needs than agency respondents. On-site training was the most preferred learning format, and time constraints were the biggest barrier to accessing learning opportunities. Participants had access to technology. Next steps include conducting key informant and focus group interviews to determine if interest in a learning need is the same as a relevant knowledge and practice gap. This research suggests that cancer care providers are interested in learning more about the psychosocial issues related to cancer care. PMID:20361284

  17. Breast Cancer Risk Assessment: Moving Beyond BRCA 1 and 2.

    Science.gov (United States)

    Scalia-Wilbur, Jennifer; Colins, Bradley L; Penson, Richard T; Dizon, Don S

    2016-01-01

    The National Cancer Institute estimates that 12.3% of all women (about 1 in 8) would be diagnosed with breast cancer throughout their lifetime. In 2015, a projected 231,840 new cases are expected in the United States, accompanied by 40,290 deaths. Presently, breast cancer is responsible for 6.8% of all cancer deaths, and roughly 30% of all cancers in women. Since the discovery of the BRCA gene in 1994, efforts have been made to develop effective screening methods for breast cancer detection. Although the BRCA gene certainly opened the door to breast cancer genetics, a wide variety of new genes have recently been linked to breast cancer risk, and the tools to screen for genes beyond just BRCA1 and BRCA2 are available. However, the indications for both screening and prevention of inherited predispositions beyond BRCA1 and BRCA2 are not entirely clear, and as a result, much of the ongoing work is aimed at determining the role of broader genetic screening in women deemed at sufficiently high risk for breast cancer based on family history. On this topic, we provide a brief overview of the genes associated with breast cancer risk as well as the technological platforms available to patients. We conclude by discussing recommendations of expert groups and what they practically mean for patients. PMID:26617204

  18. EMSP Final Report: Electrically Driven Technologies for Radioactive Aerosol Abatement

    Energy Technology Data Exchange (ETDEWEB)

    DePaoli, D.W.

    2003-01-22

    The purpose of this research project was to develop an improved understanding of how electrically driven processes, including electrocoalescence, acoustic agglomeration, and electric filtration, may be employed to efficiently treat problems caused by the formation of aerosols during DOE waste treatment operations. The production of aerosols during treatment and retrieval operations in radioactive waste tanks and during thermal treatment operations such as calcination presents a significant problem of cost, worker exposure, potential for release, and increased waste volume. There was anecdotal evidence in the literature that acoustic agglomeration and electrical coalescence could be used together to change the size distribution of aerosol particles in such a way as to promote easier filtration and less frequent maintenance of filtration systems. As such, those electrically driven technologies could potentially be used as remote technologies for improved treatment; however, existing theoretical models are not suitable for prediction and design. To investigate the physics of such systems, and also to prototype a system for such processes, a collaborative project was undertaken between Oak Ridge National Laboratory (ORNL) and the University of Texas at Austin (UT). ORNL was responsible for the larger-scale prototyping portion of the project, while UT was primarily responsible for the detailed physics in smaller scale unit reactors. It was found that both electrical coalescence and acoustic agglomeration do in fact increase the rate of aggregation of aerosols. Electrical coalescence requires significantly less input power than acoustic agglomeration, but it is much less effective in its ability to aggregate/coalesce aerosols. The larger-scale prototype showed qualitatively similar results as the unit reactor tests, but presented more difficulty in interpretation of the results because of the complex multi-physics coupling that necessarily occur in all larger

  19. Technology assessment of geothermal pumping equipment. final report, July 1978

    Energy Technology Data Exchange (ETDEWEB)

    Nichols, K.E.; Malgieri, A.J.

    1978-09-01

    Twenty-eight separate interviews were conducted with DOE personnel, DOE contractors doing geothermal research, persons associated with geothermal installations, companies engaged in the drilling and completion of geothermal well, and pump manufactures. The reports of these interviews are presented and summarized and conclusions are drawn.

  20. Study of the Accelerator Technology Development for Cancer Radiotherapy

    International Nuclear Information System (INIS)

    The hadronic particle beams including both protons, neutrons and charged particles have been studied for cancer therapy by a number of research centers in several countries during the past two decades. In this paper is briefly discussed concerning the accelerator type and its applications. The future trends are seen in the new technological developments like the use of proton gantries, beam scanning techniques, improved patient handling system and in the increasing precision of treatment. (author)

  1. Hellsgate Winter Range : Wildlife Mitigation Project. Final Environmental Assessment.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1995-03-01

    Bonneville Power Administration (BPA) proposes to fund the Hellsgate Winter Range Wildlife Mitigation Project (Project) in a cooperative effort with the Colville Confederated Tribes and the Bureau of Indian Affairs (BIA). The proposed action would allow the sponsors to secure property and conduct wildlife management activities within the boundaries of the Colville Indian Reservation. This Final Environmental Assessment (EA) examines the potential environmental effects of acquiring and managing property for wildlife and wildlife habitat within a large project area. This area consists of several separated land parcels, of which 2,000 hectares (4,943 acres) have been purchased by BPA and an additional 4,640 hectares (11,466 acres) have been identified by the Colville Confederated Tribes for inclusion in the Project. Four proposed activities (habitat protection, habitat enhancement, operation and maintenance, and monitoring and evaluation) are analyzed. The proposed action is intended to meet the need for mitigation of wildlife and wildlife habitat that was adversely affected by the construction of Grand Coulee and Chief Joseph Dams and their reservoirs.

  2. Hellsgate Winter Range: Wildlife mitigation project. Final environmental assessment

    International Nuclear Information System (INIS)

    Bonneville Power Administration (BPA) proposes to fund the Hellsgate Winter Range Wildlife Mitigation Project (Project) in a cooperative effort with the Colville Confederated Tribes and the Bureau of Indian Affairs (BIA). The proposed action would allow the sponsors to secure property and conduct wildlife management activities within the boundaries of the Colville Indian Reservation. This Final Environmental Assessment (EA) examines the potential environmental effects of acquiring and managing property for wildlife and wildlife habitat within a large project area. This area consists of several separated land parcels, of which 2,000 hectares (4,943 acres) have been purchased by BPA and an additional 4,640 hectares (11,466 acres) have been identified by the Colville Confederated Tribes for inclusion in the Project. Four proposed activities (habitat protection, habitat enhancement, operation and maintenance, and monitoring and evaluation) are analyzed. The proposed action is intended to meet the need for mitigation of wildlife and wildlife habitat that was adversely affected by the construction of Grand Coulee and Chief Joseph Dams and their reservoirs

  3. Blue Creek Winter Range: Wildlife Mitigation Project. Final environmental assessment

    International Nuclear Information System (INIS)

    Bonneville Power Administration (BPA) proposes to fund that portion of the Washington Wildlife Agreement pertaining to the Blue Creek Winter Range Wildlife Mitigation Project (Project) in a cooperative effort with the Spokane Tribe, Upper Columbia United Tribes, and the Bureau of Indian Affairs (BIA). If fully implemented, the proposed action would allow the sponsors to protect and enhance 2,631 habitat units of big game winter range and riparian shrub habitat on 2,185 hectares (5,400 acres) of Spokane Tribal trust lands, and to conduct long term wildlife management activities within the Spokane Indian Reservation project area. This Final Environmental Assessment (EA) examines the potential environmental effects of securing land and conducting wildlife habitat enhancement and long term management activities within the boundaries of the Spokane Indian Reservation. Four proposed activities (habitat protection, habitat enhancement, operation and maintenance, and monitoring and evaluation) are analyzed. The proposed action is intended to meet the need for mitigation of wildlife and wildlife habitat adversely affected by the construction of Grand Coulee Dam and its reservoir

  4. Blue Creek Winter Range : Wildlife Mitigation Project : Final Environmental Assessment.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration; United States. Bureau of Indian Affairs; Spokane Tribe of the Spokane Reservation, Washington

    1994-11-01

    Bonneville Power Administration (BPA) proposes to fund that portion of the Washington Wildlife Agreement pertaining to the Blue Creek Winter Range Wildlife Mitigation Project (Project) in a cooperative effort with the Spokane Tribe, Upper Columbia United Tribes, and the Bureau of Indian Affairs (BIA). If fully implemented, the proposed action would allow the sponsors to protect and enhance 2,631 habitat units of big game winter range and riparian shrub habitat on 2,185 hectares (5,400 acres) of Spokane Tribal trust lands, and to conduct long term wildlife management activities within the Spokane Indian Reservation project area. This Final Environmental Assessment (EA) examines the potential environmental effects of securing land and conducting wildlife habitat enhancement and long term management activities within the boundaries of the Spokane Indian Reservation. Four proposed activities (habitat protection, habitat enhancement, operation and maintenance, and monitoring and evaluation) are analyzed. The proposed action is intended to meet the need for mitigation of wildlife and wildlife habitat adversely affected by the construction of Grand Coulee Dam and its reservoir.

  5. 2005 Final Report: New Technologies for Future Colliders

    International Nuclear Information System (INIS)

    This document presents an annual report on our long-term R and D grant for development of new technology for future colliders. The organizing theme of our development is to develop a compact high-field collider dipole, utilizing wind-and-react Nb3Sn coil fabrication, stress management, conductor optimization, bladder preload, and flux plate suppression of magnetization multipoles. The development trail for this new technology began over four years ago with the successful testing of TAMU12, a NbTi model in which we put to a first test many of the construction details of the high-field design. We have built TAMU2, a mirror-geometry dipole containing a single coil module of the 3-module set required for the 14 Tesla design. This first Nb3Sn model was built using ITER conductor which carries much less current than high-performance conductor but enables us to prove in practice our reaction bake and impregnation strategies with ''free'' superconductor. TAMU2 has been shipped to LBNL for testing. Work is beginning on the construction of TAMU3, which will contain two coil modules of the 14 Tesla design. TAMU3 has a design field of 13.5 Tesla and will enable us to fully evaluate the issues of stress management that will be important to the full design. With the completion of TAMU2 and the construction of TAMU3 the Texas A and M group ''comes of age'' in the family of superconducting magnet R and D laboratories. We have completed the phase of developing core technologies and fixtures and entered the phase of building and testing a succession of model dipoles that each build incrementally upon a proven core design

  6. Serum YKL-40 in risk assessment for colorectal cancer

    DEFF Research Database (Denmark)

    Johansen, Julia Sidenius; Christensen, Ib Jarle; Jørgensen, Lars Nannestad;

    2015-01-01

    to endoscopy due to symptoms or other risk factors for colorectal cancer. Blood samples were collected just before large bowel endoscopy. Serum YKL-40 was determined by ELISA. Serum YKL-40 was higher (P < 0.0001, unadjusted for confounding covariates) in subjects diagnosed with colon cancer (median......The aim of the present study was to test the hypothesis that high serum YKL-40 associates with colorectal cancer in subjects at risk of colorectal cancer. We measured serum YKL-40 in a prospective study of 4,496 Danish subjects [2,064 men, 2,432 women, median age 61 years (range, 18-97)] referred...... useful in combination with other biomarkers in risk assessment for colorectal cancer. Cancer Epidemiol Biomarkers Prev; 24(3); 621-6. ©2015 AACR....

  7. Remote equipment technology. Final report for GFY 1880

    International Nuclear Information System (INIS)

    An interactive graphics terminal and a desk-top computer were utilized to perform a Computer Aided Remote Maintenance simulation of a hypothetical equipment item. The equipment item included an electrical connection, hydraulic fitting, and simple bolt pattern which were maintained by remote manipulators during the simulation. These remote maintenance operations demonstrated that the Computer Aided Remote Maintenance simulation technology could be extended to complex equipment items. As a result, these equipment items can be evaluated from the standpoint of remote operation and maintenance prior to purchase or installation in a remote processing or cell arrangement

  8. Remote equipment technology. Final report for GFY 1880

    Energy Technology Data Exchange (ETDEWEB)

    Wadekamper, D.C.

    1980-09-01

    An interactive graphics terminal and a desk-top computer were utilized to perform a Computer Aided Remote Maintenance simulation of a hypothetical equipment item. The equipment item included an electrical connection, hydraulic fitting, and simple bolt pattern which were maintained by remote manipulators during the simulation. These remote maintenance operations demonstrated that the Computer Aided Remote Maintenance simulation technology could be extended to complex equipment items. As a result, these equipment items can be evaluated from the standpoint of remote operation and maintenance prior to purchase or installation in a remote processing or cell arrangement.

  9. Uncertainties related to the identification of the marginal energy technology in consequential life cycle assessments

    DEFF Research Database (Denmark)

    Mathiesen, B.V.; Münster, Marie; Fruergaard, Thilde

    2009-01-01

    When performing life cycle assessment (LCA) assumptions regarding the energy use are often decisive for the outcome. In this paper, current approaches of identifying marginal electricity and heat technologies for consequential LCAs are challenged. The identification of marginal energy technologies...... is examined from three angles: The marginal electricity technology is identified in Danish historical and potential future energy systems. The methods of identifying and using marginal electricity and heat technologies in key LCA studies are analysed. Finally, the differences in applying energy...... system analysis and assuming one marginal technology are illustrated, using waste incineration with energy substitution as a case. The main problem with the current approach is the use of one single marginal technology. It is recommended to use fundamentally different affected technologies and identify...

  10. Assessment of selected furnace technologies for RWMC waste

    International Nuclear Information System (INIS)

    This report provides a description and initial evaluation of five selected thermal treatment (furnace) technologies, in support of earlier thermal technologies scoping work for application to the Idaho National Engineering Laboratory Radioactive Waste Management Complex (RWMC) buried wastes. The cyclone furnace, molten salt processor, microwave melter, ausmelt (fuel fired lance) furnace, and molten metal processor technologies are evaluated. A system description and brief development history are provided. The state of development of each technology is assessed, relative to treatment of RWMC buried waste

  11. Assessment of selected furnace technologies for RWMC waste

    Energy Technology Data Exchange (ETDEWEB)

    Batdorf, J.; Gillins, R. (Science Applications International Corp., Idaho Falls, ID (United States)); Anderson, G.L. (EG and G Idaho, Inc., Idaho Falls, ID (United States))

    1992-03-01

    This report provides a description and initial evaluation of five selected thermal treatment (furnace) technologies, in support of earlier thermal technologies scoping work for application to the Idaho National Engineering Laboratory Radioactive Waste Management Complex (RWMC) buried wastes. The cyclone furnace, molten salt processor, microwave melter, ausmelt (fuel fired lance) furnace, and molten metal processor technologies are evaluated. A system description and brief development history are provided. The state of development of each technology is assessed, relative to treatment of RWMC buried waste.

  12. GRANITE CUTTING WASTE: TECHNOLOGICAL INNOVATION FOR THE FINAL DESTINATION

    Directory of Open Access Journals (Sweden)

    Joner Oliveira Alves

    2015-06-01

    Full Text Available The granite processing market is one of the most promising business areas of the mineral sector, with an average growth of the world production of about 6% per year. The granite extraction generates residues in the form of powder rock of 20-25 wt.% of the total benefited. The granite dust must be carefully managed since it can cause siltation of rivers and human health risks. This paper presents two routes for the final destination of this waste: the vitrification process aiming the production of fibers for thermo-acoustic insulation, and the magnetic separation in order to recover the steel grit. Results showed that the forms of treatments presented are economically and ecologically viable since they represent a cost reduction in the waste disposal, and also provide the production of new materials with commercial value.

  13. Technology commercialization cost model and component case study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1991-12-01

    Fuel cells seem poised to emerge as a clean, efficient, and cost competitive source of fossil fuel based electric power and thermal energy. Sponsors of fuel cell technology development need to determine the validity and the attractiveness of a technology to the market in terms of meeting requirements and providing value which exceeds the total cost of ownership. Sponsors of fuel cell development have addressed this issue by requiring the developers to prepare projections of the future production cost of their fuel cells in commercial quantities. These projected costs, together with performance and life projections, provide a preliminary measure of the total value and cost of the product to the customer. Booz-Allen & Hamilton Inc. and Michael A. Cobb & Company have been retained in several assignments over the years to audit these cost projections. The audits have gone well beyond a simple review of the numbers. They have probed the underlying technical and financial assumptions, the sources of data on material and equipment costs, and explored issues such as the realistic manufacturing yields which can be expected in various processes. Based on the experience gained from these audits, the DOE gave Booz-Allen and Michael A. Cobb & company the task to develop a criteria to be used in the execution of future fuel cell manufacturing cost studies. It was thought that such a criteria would make it easier to execute such studies in the future as well as to cause such studies to be more understandable and comparable.

  14. Final Technical Report. Training in Building Audit Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Brosemer, Kathleen [Sault Sainte Marie Tribe of Chippewa Indians, Marie, MI (United States)

    2015-03-27

    In 2011, the Tribe proposed and was awarded the Training in Building Audit Technologies grant from the DOE in the amount of $55,748 to contract for training programs for infrared cameras, blower door technology applications and building systems. The coursework consisted of; Infrared Camera Training: Level I - Thermal Imaging for Energy Audits; Blower Door Analysis and Building-As-A-System Training, Building Performance Institute (BPI) Building Analyst; Building Envelope Training, Building Performance Institute (BPI) Envelope Professional; and Audit/JobFLEX Tablet Software. Competitive procurement of the training contractor resulted in lower costs, allowing the Tribe to request and receive DOE approval to additionally purchase energy audit equipment and contract for residential energy audits of 25 low-income Tribal Housing units. Sault Tribe personnel received field training to supplement the classroom instruction on proper use of the energy audit equipment. Field experience was provided through the second DOE energy audits grant, allowing Sault Tribe personnel to join the contractor, Building Science Academy, in conducting 25 residential energy audits of low-income Tribal Housing units.

  15. Technology assessments in transportation: survey of recent literature

    Energy Technology Data Exchange (ETDEWEB)

    LaBelle, S.J.

    1980-03-01

    A survey and an evaluation of recent studies of transportation systems done in a technology-assessment framework were undertaken as the basis for a detailed statement of work for a US Department of Energy technology assessment of transportation energy-conservation strategies. Several bibliographies were searched and numerous professionals in the field of technology assessment were contacted regarding current work. Detailed abstracts were prepared for studies judged to be sufficiently broad in coverage of impacts assessed, yet detailed in coverage of all or part of the nation's transportation systems. Some studies were rich in data but not comprehensive in their analytical approach; brief abstracts were prepared for these. An explanation of the criteria used to screen the studies, as well as abstracts of 37 reports, are provided in this compendium of transportation-technology-assessment literature.

  16. Superconducting Technology Assessment (NSA, Office of Corporate Assessments)

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — The government, and particularly NSA, has a continuing need for ever-increasing computational power. The Agency is concerned about projected limitations of...

  17. Nonproliferation criteria for assessing civilian nuclear technologies

    International Nuclear Information System (INIS)

    Two trends are affecting the spread of nuclear weapons. One is the growing access to readily fissionable materials as a by-product of the spread of civilian nuclear technology. The second is the fact that many countries acquiring easier access also have an increased incentive to acquire nuclear explosives, or at least to shorten the lead time to them. Nonproliferation strategies might seek to influence the demand for nuclear explosives through improved alliance ties, regional security associations, and nuclear free zones, as well as the ease of access to explosives through agreement on increasing the difficulty of each access through changes in international agreements on technologies, or through a mix of such measures. The discussion focuses on a supply-oriented strategy, not because such a strategy by itself is likely to be optimal, but because it would be a significant component of a broad strategy, and it is the one that has been central to the nonproliferation efforts of the United States in the past several years. A supply-oriented strategy could have two components: 1. A set of incentives for choosing less dangerous nuclear systems instead of more dangerous ones (and in some cases the choosing of non-nuclear rather than nuclear technologies); 2. A set of political agreements restricting especially dangerous systems or components of systems. For such a strategy to have a prospect of being effective, it should encompass all the paths to a bomb from a legitimate safeguarded state. Specifically, it should include: 1. Paths starting from large plutonium reactors, including those labeled research reactors; 2. Isotope separation technologies; 3. Power-reactors-related paths, based on using either a. Material available at the front end, or b. Material available at the back end; and 4 Various possible future technologies, such as accelerator breeders or fusion-fission technology. Some illustrative cases are discussed

  18. Technology and public policy: The process of technology assessment in the federal government

    Science.gov (United States)

    Coates, V. T.

    1975-01-01

    A study was conducted to provide a descriptive and analytical review of the concept of technology assessment and the current status of its applications in the work of the federal executive agencies. The origin of the term technology assessment was examined along with a brief history of its discussion and development since 1966 and some of the factors influencing that development.

  19. 20 Years of Technology and Language Assessment in "Language Learning & Technology"

    Science.gov (United States)

    Chapelle, Carol A.; Voss, Erik

    2016-01-01

    This review article provides an analysis of the research from the last two decades on the theme of technology and second language assessment. Based on an examination of the assessment scholarship published in "Language Learning & Technology" since its launch in 1997, we analyzed the review articles, research articles, book reviews,…

  20. The development of integrated safety assessment technology

    International Nuclear Information System (INIS)

    For the purpose of developing the integrated PSA methodology and computer codes, Level-1 and Level-2 PSA methodology and tools were reviewed and improved. The Level-1 PSA computer code package KIRAP was improved and released by the name of KIRAP Release 2.0 Several Human reliability analysis and common cause failure analysis methods was reviewed and compared. For the development of Level-2 PSA computer code, several level-1 and Level-2 interface methods and containment event tree development methods were reviewed and compared. And the new technology such as artificial intelligence was reviewed if the technology can be applied to the development of PSA methodology.(Author)

  1. Biomedical Technology Assessment The 3Q Method

    CERN Document Server

    Weinfurt, Phillip

    2010-01-01

    Evaluating biomedical technology poses a significant challenge in light of the complexity and rate of introduction in today's healthcare delivery system. Successful evaluation requires an integration of clinical medicine, science, finance, and market analysis. Little guidance, however, exists for those who must conduct comprehensive technology evaluations. The 3Q Method meets these present day needs. The 3Q Method is organized around 3 key questions dealing with 1) clinical and scientific basis, 2) financial fit and 3) strategic and expertise fit. Both healthcare providers (e.g., hospitals) an

  2. Innovative and Alternative Technology Assessment Manual

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-02-01

    This four chapter, six appendix manual presents the procedures and methodology as well as the baseline costs and energy information necessary for the analysis and evaluation of innovative and alternative technology applications submitted for federal grant assistance under the innovative and alternative technology provisions of the Clean Water Act of 1977. The manual clarifies and interprets the intent of Congress and the Environmental Protection Agency in carrying out the mandates of the innovative and alternative provisions of the Clean Water Act of 1977. [DJE 2005

  3. LNG vehicle technology, economics, and safety assessment

    Science.gov (United States)

    Powars, Charles A.; Moyer, Carl B.; Lowell, Douglas D.

    1994-02-01

    Liquid natural gas (LNG) is an attractive transportation fuel because of its high heating value and energy density (i.e., Btu/lb. and Btu/gal.), clean burning characteristics, relatively low cost ($/Btu), and domestic availability. This research evaluated LNG vehicle and refueling system technology, economics, and safety. Prior and current LNG vehicle projects were studied to identify needed technology improvements. Life-cycle cost analyses considered various LNG vehicle and fuel supply options. Safety records, standards, and analysis methods were reviewed. The LNG market niche is centrally fueled heavy-duty fleet vehicles with high fuel consumption. For these applications, fuel cost savings can amortize equipment capital costs.

  4. Technology development risk assessment and mixed interests

    International Nuclear Information System (INIS)

    The main purpose of this work is to demonstrate by means of a critical analysis of the state-of-the-art in technological and environmental risk analysis and decision making, that risk and environmental management decisions involve heterogeneous groups of social actors, each representing conflicting interests. It is argued that risk analyses should therefore be based on social interaction and communication paradigma, as well as, on a new rational way of thinking concerning the optimum choice of suitable technological development strategies leading towards a publicly acceptable balance between national energy-economic strategic necessities and social and individual perception of risk

  5. Technology review of commercial food service equipment - final report

    Energy Technology Data Exchange (ETDEWEB)

    Rahbar, S.; Krsikapa, S. [Canadian Gas Research Inst., Don Mills, ON (Canada); Fisher, D.; Nickel, J.; Ardley, S.; Zabrowski, D. [Fisher Consultants (Canada); Barker, R.F. [ed.

    1996-05-15

    Market and technical information on gas fired equipment used in the commercial food service sector in Canada and in each province or territory was presented. Results of a market study and technology review were integrated to establish energy consumption and energy saving potential in this sector. Eight categories of commercial cooking appliances were studied. They were: fryers, griddles, broilers, ranges, ovens, tilting skillets, steam kettles and steamers. Focus was on gas fired appliances, although electric appliances were also included. The total energy consumption of the appliances was estimated at 76,140.37 GBtu in 1994. Gas appliances accounted for 63 per cent of the total inventory and consumed 83 per cent of the total energy used. Cooking energy efficiencies for the gas fired commercial cooking equipment ranged from 10 per cent to 60 per cent. The electric appliances had cooking energy efficiencies ranging from 35 per cent to 95 per cent. A list of recommendations were made for the many opportunities to introduce higher efficiency commercial cooking appliances, essential to slow down or to stabilize the energy consumption of cooking appliances over the next decade. 66 refs., 14 tabs., 18 figs.

  6. Technology verification phase. Dynamic isotope power system. Final report

    International Nuclear Information System (INIS)

    The Phase I requirements of the Kilowatt Isotope Power System (KIPS) program were to make a detailed Flight System Conceptual Design (FSCD) for an isotope fueled organic Rankine cycle power system and to build and test a Ground Demonstration System (GDS) which simulated as closely as possible the operational characteristics of the FSCD. The activities and results of Phase II, the Technology Verification Phase, of the program are reported. The objectives of this phase were to increase system efficiency to 18.1% by component development, to demonstrate system reliability by a 5000 h endurance test and to update the flight system design. During Phase II, system performance was improved from 15.1% to 16.6%, an endurance test of 2000 h was performed while the flight design analysis was limited to a study of the General Purpose Heat Source, a study of the regenerator manufacturing technique and analysis of the hardness of the system to a laser threat. It was concluded from these tests that the GDS is basically prototypic of a flight design; all components necessary for satisfactory operation were demonstrated successfully at the system level; over 11,000 total h of operation without any component failure attested to the inherent reliability of this type of system; and some further development is required, specifically in the area of performance

  7. Technology Cost and Schedule Estimation (TCASE) Final Report

    Science.gov (United States)

    Wallace, Jon; Schaffer, Mark

    2015-01-01

    During the 2014-2015 project year, the focus of the TCASE project has shifted from collection of historical data from many sources to securing a data pipeline between TCASE and NASA's widely used TechPort system. TCASE v1.0 implements a data import solution that was achievable within the project scope, while still providing the basis for a long-term ability to keep TCASE in sync with TechPort. Conclusion: TCASE data quantity is adequate and the established data pipeline will enable future growth. Data quality is now highly dependent the quality of data in TechPort. Recommendation: Technology development organizations within NASA should continue to work closely with project/program data tracking and archiving efforts (e.g. TechPort) to ensure that the right data is being captured at the appropriate quality level. TCASE would greatly benefit, for example, if project cost/budget information was included in TechPort in the future.

  8. Dialogic Global Studies for Multicultural Technology Assessment

    Science.gov (United States)

    Durakovic, Emina; Feigl, Britta Marion; Fischer, Bettina Marion; Fleck, Christopher; Galler, Lisa-Maria; Heinrich, Johannes; Kulmer, Karin; Kurzweil, Birgitta; Scholze, Markus; Sperl, Raphael Stefan; Unterkofler, Rene; Remele, Kurt; Matzenberger, Julian; Ahamer, Gilbert

    2012-01-01

    Purpose: The purpose of this paper is to show a practical case of dialogic web-based learning that has provided a set of questions analysing two complex technological projects in "southern" countries with effects on multicultural equity. Design/methodology/approach: Structured online review processes in multicultural and systems science curricula…

  9. Constructive Technology Assessment for HIT development

    DEFF Research Database (Denmark)

    Høstgaard, Anna Marie Balling; Bertelsen, Pernille; Petersen, Lone Stub;

    2013-01-01

    -users. The CTA methodology is based on a Socio-technical understanding of technological development as an open ended, emergent process. The CTA was used during the EHR development process in the Region of North Jutland where it proved successful inproviding learning and feedback between all relevant groups...

  10. D3.1.2. Final report on the use of emerging technologies in crisis situations

    OpenAIRE

    Kotsiopoulos, Ioannis; Yannapoulos, Angelos; In't Veld, Michiel; De Vries, David

    2015-01-01

    EXECUTIVE SUMMARY This is the final version of Deliverable D3.1 of the COSMIC project, released as D3.1.2. It provides results in the analysis of emerging communication technologies in support of crisis management. New communication technologies and social media have greatly expanded the overall scope of communication in crisis management, because of several new synergetic factors, including: access to communication technology, richer communication modalities, communication occurring ...

  11. CRADA Final Report, 2011S003, Faraday Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Faraday Technologies

    2012-12-12

    This Phase I SBIR program addressed the need for an improved manufacturing process for electropolishing niobium RF superconducting cavities for the International Linear Collider (ILC). The ILC is a proposed particle accelerator that will be used to gain a deeper understanding of the forces of energy and matter by colliding beams of electrons and positrons at nearly the speed of light. The energy required for this to happen will be achieved through the use of advanced superconducting technology, specifically ~16,000 RF superconducting cavities operating at near absolute zero. The RF superconductor cavities will be fabricated from highly pure Nb, which has an extremely low surface resistance at 2 Kelvin when compared to other materials. To take full advantage of the superconducting properties of the Nb cavities, the inner surface must be a) polished to a microscale roughness < 0.1 µm with removal of at least 100 µm of material, and b) cleaned to be free of impurities that would degrade performance of the ILC. State-of-the-art polishing uses either chemical polishing or electropolishing, both of which require hydrofluoric acid to achieve breakdown of the strong passive film on the surface. In this Phase I program, Faraday worked with its collaborators at the Thomas Jefferson National Accelerator Facility (JLab) to demonstrate the feasibility of an electropolishing process for pure niobium, utilizing an environmentally benign alternative to chemical or electrochemical polishing electrolytes containing hydrofluoric acid. Faraday utilized a 31 wt% aqueous sulfuric acid solution (devoid of hydrofluoric acid) in conjunction with the FARADAYICSM Process, which uses pulse/pulse reverse fields for electropolishing, to demonstrate the ability to electropolish niobium to the desired surface finish. The anticipated benefits of the FARADAYICSM Electropolishing process will be a simpler, safer, and less expensive method capable of surface finishing high purity niobium cavities

  12. RNAi technology: A Revolutionary tool for the colorectal cancer therapeutics

    Institute of Scientific and Technical Information of China (English)

    Wei Lv; Chao Zhang; Jia Hao

    2006-01-01

    With the many changes that have taken place in people's diet and lifestyle, colorectal cancer (CRC) has become a global concern. There were approximately 950000 new cases diagnosed and 500000 deaths recorded worldwide in 2000. It is the second most common type of cancer in the Western world, and it is the third most common type of digestive tumor in China. It is reported that the morbidity of CRC is 4.08/100000 for men and 3.30/100000 for women in China. Despite the rate of improvements in surgery, radiotherapy and chemotherapy, the overall five-year survival is around 50%. Therefore, novel treatment need to be developed in order to add to the therapeutic armamentarium.RNA interference (RNAi) is a sequence-specific posttranscriptional gene silencing mechanism, which is triggered by double-stranded RNA (dsRNA) and causes degradation of mRNA homologous in sequence to the dsRNA.This new approach has been successfully adopted to inhibit virus replication and tumorigenicity. Recent reports have described DNA vector-based strategies for delivery of small interfering RNA (siRNA) into mammalian cells, further expanding the utility of RNAi. With the development of the RNAi technology and deeper understanding of this field, a promising new modality of treatment appeared, which can be used in combination with the existing therapies .We reviewed the proceedings on the actualities and advancement of RNAi technology for colorectal cancer therapeutics.

  13. Advanced photoinjector laser and microwave technologies. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Hartemann, F.V.; Luhmann, N.C. Jr. [California Univ., Davis, CA (United States). Dept. of Applied Science; Talley, W.K. [Lawrence Livermore National Lab., CA (United States)

    1997-01-01

    An overview of the design parameters of the compact, high gradient, high luminosity X-band (8.568 GHz) photoinjector facility currently being developed as a collaborative effort between LLNL and UC Davis, is followed by a more detailed description of each of its major subsystems : X-band rf gun, GHz repetition rate synchronously modelocked AlGaAs quantum well laser oscillator, and 8-pass Ti: Al{sub 2}O{sub 3} chirped pulse laser amplifier. The photoinjector uses a high quantum efficiency ({approx}5%) Cs{sub 2}Te photocathode, and will be capable of producing high charge (> 1 nC), relativistic (5 MeV), ultrashort (< 1 ps) electron bunches at 2.142 GHz repetition rate in burst mode (100 photoelectron bunches). Design studies indicate that a normalized rms transverse emittance {epsilon}{sub n} = 0.75 {pi} mm-mrad is possible at 0.1 nC charge, while 2.5 {pi} mm-mrad can be obtained at 1 nC. A complete status report of our progress in the development and implementation of the design discussed herein is then given, together with initial experimental data concerning the performance of the 15 MW SLAC X-band klystron amplifier. Finally, the phase noise and jitter characteristics of the laser and rf systems of the high gradient X-band photoinjector have been measured experimentally. In this case, the laser oscillator is a self-modelocked Titanium:Sapphire system operating at the 108th subharmonic of the rf gun. The X-band signal is produced from the laser by a phase-locked dielectric resonance oscillator, and amplified by a pulsed TWT. A comparison between the TWT phase noise and the fields excited in the rf gun demonstrates the filtering effect of the high Q cavity resonant structure, thus indicating that the rf gun can be used as a master oscillator, and could be energized by either a magnetron or a cross-field amplifier.

  14. Texas A&M University Industrial Assessment Center Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Heffington, Warren M.; Eggebrecht, James A.

    2007-02-24

    This project benefited the public by assisting manufacturing plants in the United States to save costly energy resources and become more profitable. Energy equivalent to over 75,000 barrels of oil was conserved. The Texas A&M University Industrial Assessment Center (IAC) visited 96 manufacturing plants and spent 101 days in those plants during the contract period from August 9, 2002, through November 30, 2006. Recommended annual energy savings for manufacturers were 37,400,000 kWh (127,600 MMBtu—site basis) of electricity and 309,000 MCF (309,000 MMBtu) of natural gas. Each manufacturer subsequently was surveyed, and based on these surveys reportedly implemented 79% of the electricity savings and 36% of the natural gas savings for an overall energy savings of 48% of recommended. Almost 800 (798) projects were recommended to manufacturers, and they accomplished two-thirds of the projects. Cost savings recommended were $12.3 million and implemented savings were $5.7 million or 47%. During the contract period our average time between site visit and report submittal averaged 46 days; and decreased from 48 days in 2003 to 44 days in 2006. Serving clients well and promptly has been a priority. We visited five ESA overflow clients during FY 06. The Texas A&M University IAC pioneered the presentation of air pollution information in reports, and includes NOx and CO2 reductions due to energy savings in all reports. We also experimented with formal PowerPoint BestPractices presentations called Lunchtime/Showtime in each plant and with delivering electronic versions of the report. During the period of the contract, the director served on the Texas Industries of the Future (IOF) Refining and Chemicals Committee, which oversaw the showcases in 2003 and 2006. The assistant director was the Executive Director of the International Energy Technology Conference held annually. The director and assistant director became qualified specialists in the Process Heating Assessment Scoping

  15. Assessment Training Effects on Student Assessment Skills and Task Performance in a Technology-Facilitated Peer Assessment

    Science.gov (United States)

    Liu, Xiongyi; Li, Lan

    2014-01-01

    This study examines the impact of an assessment training module on student assessment skills and task performance in a technology-facilitated peer assessment. Seventy-eight undergraduate students participated in the study. The participants completed an assessment training exercise, prior to engaging in peer-assessment activities. During the…

  16. HPCC technology awareness program: Improved economic competitiveness through technology awareness, transfer and application. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1994-04-01

    A need has been defined by Congress for the DOE National Laboratories to participate in various dual use and technology transfer programs. This requirement has spawned several technology transfer approaches at the DOE laboratories. These programs are designed to encourage large and small business to bring their problems and needs forward, and to allow the labs to transfer effective high performance computing technology to the commercial marketplace. This IG Technologies grant from the DOE was undertaken to address the issues and problems associated with technology transfer between the DOE National Laboratories and commercial industry. The key focus is to gain an understanding of how DOE and industry independently and collectively view the requirements and the missing elements that could allow DOE to facilitate HPCC technology transfer. At issue is HPCC Technology Transfer for the High Performance Computing industry and its relationship to the DOE National Laboratories. Several observations on this are addressed. The issue of a ``Technology Utilization Gap`` between the National Laboratories and Independent Software Vendors is discussed. This study addressed the HPCC Technology Transfer plans of all six DOE National Labs. Study team members briefed numerous industrial users of HPCC technology as to the feasibility of technology transfer for various applications. Significant findings of the effort are that the resistance to technology transfer is much higher than anticipated for both the National Labs and industry. Also, HPCC Technology Transfer is observed to be a large company`s dominion. Small businesses have a difficult time in addressing the requirements of technology transfer using Cooperative Research and Development Agreements (CRADA`s). Large businesses and the DOE National Labs however, often have requirements and objectives which are at cross purposes, making effective technology transfer difficult.

  17. Optimizing HER2 assessment in breast cancer

    DEFF Research Database (Denmark)

    Holten-Rossing, Henrik; Møller Talman, Maj-Lis; Kristensson, Martin;

    2015-01-01

    In breast cancer, analysis of HER2 expression is pivotal for treatment decision. This study aimed at comparing digital, automated image analysis with manual reading using the HER2-CONNECT algorithm (Visiopharm) in order to minimize the number of equivocal 2+ scores and the need for reflex...

  18. IMPROVING HOSPITAL LOGISTICS BY RETHINKING TECHNOLOGY ASSESSMENT

    DEFF Research Database (Denmark)

    Jacobsen, Peter; Jørgensen, Pelle Morten Thomas

    2011-01-01

    In order to cope with the future challenges of the health care sector, there is an urging need for improving efficiency at hospitals. The study presents a framework enabling health care managers of improving the in-house logistics. The distinctiveness of the framework is the way in which it relates...... technology, logistics, structure and procedures to efficiency. Changing one factor e.g. technology, initiates an iterative loop focusing on change in the related factors in order to obtain the optimal efficiency. The search for an optimal efficient solution is the driving force of the framework, and will...... Danish hospital. The framework is tested on the blood sample logistics between the emergency department and laboratory with the goal of enhancing the efficiency of the emergency department....

  19. Radioactive scrap metal decontamination technology assessment report

    International Nuclear Information System (INIS)

    Within the DOE complex there exists a tremendous quantity of radioactive scrap metal. As an example, it is estimated that within the gaseous diffusion plants there exists in excess of 700,000 tons of contaminated stainless steel. At present, valuable material is being disposed of when it could be converted into a high quality product. Liquid metal processing represents a true recycling opportunity for this material. By applying the primary production processes towards the material's decontamination and re-use, the value of the strategic resource is maintained while drastically reducing the volume of material in need of burial. Potential processes for the liquid metal decontamination of radioactively contaminated metal are discussed and contrasted. Opportunities and technology development issues are identified and discussed. The processes compared are: surface decontamination; size reduction, packaging and burial; melting technologies; electric arc melting; plasma arc centrifugal treatment; air induction melting; vacuum induction melting; and vacuum induction melting and electroslag remelting

  20. Radioactive scrap metal decontamination technology assessment report

    Energy Technology Data Exchange (ETDEWEB)

    Buckentin, J.M.; Damkroger, B.K.; Schlienger, M.E. [Sandia National Labs., Albuquerque, NM (United States). Liquid Metal Processing Lab.

    1996-04-01

    Within the DOE complex there exists a tremendous quantity of radioactive scrap metal. As an example, it is estimated that within the gaseous diffusion plants there exists in excess of 700,000 tons of contaminated stainless steel. At present, valuable material is being disposed of when it could be converted into a high quality product. Liquid metal processing represents a true recycling opportunity for this material. By applying the primary production processes towards the material`s decontamination and re-use, the value of the strategic resource is maintained while drastically reducing the volume of material in need of burial. Potential processes for the liquid metal decontamination of radioactively contaminated metal are discussed and contrasted. Opportunities and technology development issues are identified and discussed. The processes compared are: surface decontamination; size reduction, packaging and burial; melting technologies; electric arc melting; plasma arc centrifugal treatment; air induction melting; vacuum induction melting; and vacuum induction melting and electroslag remelting.

  1. Health-Care Technology Assessment in Radiology

    OpenAIRE

    Arash Deljou

    2010-01-01

    Health-care service provision and procurement is increasingly subject to policy decisions, managed more than ever before. Becoming more international, collaboration is increasing as the health professions, research and industry all work across borders. Differing health-care systems across the countries result from national and regional policy developments and priorities."nIn health-care, all interventions and procedures are basically technologies-including radiology and sur-gery, and tec...

  2. Space Propulsion Synergy Group ETO technology assessments

    Science.gov (United States)

    Bray, James

    There exists within the aerospace community a widely recognized need to improve future space launch systems. While these needs have been expressed by many national committees, potential solutions have not achieved consensus nor have they endured. Facing the challenge to remain competitive with limited national resources, the U.S. must improve its strategic planning efforts. A nationally accepted strategic plan for space would enable a focused research & development program. The Space Propulsion Synergy Group (SPSG), chartered to support long range strategic planning, has achieved several breakthroughs. First, using a broad industry/government team, the SPSG evaluated and achieved consensus on the vehicles, propulsion systems, and propulsion technologies that have the best long term potential for achieving desired system attributes. The breakthrough that enabled broad consensus was developing criteria that are measurable a-priori. Second, realizing that systems having the best long term payoffs can loose support when constraints are tight, the SPSG invented a dual prioritization approach that balances long term strategic thrusts with current programmatic constraints. This breakthrough enables individual program managers to make decisions based on both individual project needs and long term strategic needs. Results indicate that a SSTO using an integrated modular engine has the best long term potential for a 20 Klb class vehicle and that health monitoring and control technologies rank among the highest dual priority liquid rocket technologies.

  3. Apperception and assessment of technological risks

    International Nuclear Information System (INIS)

    Risk is defined to be the possibility to induce damage or loss. Any person confronted with risk in his activities has to assess the risk in every case. The author explains a number of actions and events that have been worked out to train people in better management of risk, especially in the working environment. (DG)

  4. Mastoidectomy performance assessment of virtual simulation training using final-product analysis

    DEFF Research Database (Denmark)

    Andersen, Steven A W; Cayé-Thomasen, Per; Sørensen, Mads S

    2015-01-01

    OBJECTIVES/HYPOTHESIS: The future development of integrated automatic assessment in temporal bone virtual surgical simulators calls for validation against currently established assessment tools. This study aimed to explore the relationship between mastoidectomy final-product performance assessmen...

  5. Climate Change Vulnerability Assessments: Four Case Studies of Water Utility Practices (2011 Final)

    Science.gov (United States)

    EPA is releasing the final report titled, Climate Change Vulnerability Assessments: Four Case Studies of Water Utility Practices. This report was prepared by the National Center for Environmental Assessment's Global Climate Research Staff in the Office of Research and Developmen...

  6. Illustrating anticipatory life cycle assessment for emerging photovoltaic technologies.

    Science.gov (United States)

    Wender, Ben A; Foley, Rider W; Prado-Lopez, Valentina; Ravikumar, Dwarakanath; Eisenberg, Daniel A; Hottle, Troy A; Sadowski, Jathan; Flanagan, William P; Fisher, Angela; Laurin, Lise; Bates, Matthew E; Linkov, Igor; Seager, Thomas P; Fraser, Matthew P; Guston, David H

    2014-09-16

    Current research policy and strategy documents recommend applying life cycle assessment (LCA) early in research and development (R&D) to guide emerging technologies toward decreased environmental burden. However, existing LCA practices are ill-suited to support these recommendations. Barriers related to data availability, rapid technology change, and isolation of environmental from technical research inhibit application of LCA to developing technologies. Overcoming these challenges requires methodological advances that help identify environmental opportunities prior to large R&D investments. Such an anticipatory approach to LCA requires synthesis of social, environmental, and technical knowledge beyond the capabilities of current practices. This paper introduces a novel framework for anticipatory LCA that incorporates technology forecasting, risk research, social engagement, and comparative impact assessment, then applies this framework to photovoltaic (PV) technologies. These examples illustrate the potential for anticipatory LCA to prioritize research questions and help guide environmentally responsible innovation of emerging technologies. PMID:25121583

  7. Quadrennial Technology Review 2015: Technology Assessments--Wind Power

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2015-10-07

    Wind power has become a mainstream power source in the U.S. electricity portfolio, supplying 4.9% of the nation’s electricity demand in 2014. With more than 65 GW installed across 39 states at the end of 2014, utility-scale wind power is a cost-effective source of low-emissions power generation throughout much of the nation. The United States has significant sustainable land-based and offshore wind resource potential, greater than 10 times current total U.S. electricity consumption. A technical wind resource assessment conducted by the Department of Energy (DOE) in 2009 estimated that the land-based wind energy potential for the contiguous United States is equivalent to 10,500 GW capacity at 80 meters (m) hub and 12,000 GW capacity at 100 meters (m) hub heights, assuming a capacity factor of at least 30%. A subsequent 2010 DOE report estimated the technical offshore wind energy potential to be 4,150 GW. The estimate was calculated from the total offshore area within 50 nautical miles of shore in areas where average annual wind speeds are at least 7 m per second at a hub height of 90 m.

  8. Comprehensive geriatric assessment basics for the cancer professional.

    Science.gov (United States)

    Extermann, Martine

    2003-01-01

    A comprehensive geriatric assessment (CGA) has been a cornerstone of geriatric practice for many years. However, oncology practitioners are still unfamiliar with it. Yet, recent research has shown an important potential to improve the daily care of older cancer patients. The purpose of this article is to review the basic nature of a CGA, its effectiveness, its applicability to cancer patients, and its cost-effectiveness. Cancer is one of the major health problems in our society. Furthermore, the incidence of cancer increases with age. Nowadays, half of the cancers occur beyond the age of 70. Given the aging of the US population, this proportion is expected to increase in the next decades. A challenge for the oncologists is that older people can have a highly variable health status. Yet little is known yet about how to best assess and integrate into decision making the various health problems patients may have. Taking their clues from the experience of geriatricians, geriatric oncologists advocate the use of a comprehensive geriatric assessment (CGA) as one of the tools to deal with this problem. It is, for example, part of the National Comprehensive Cancer Network (NCCN) guidelines for the elderly'. This article offers a primer on CGA for the reader unfamiliar with the approach in an oncologic setting. PMID:12699111

  9. Photopneumatic Technology in Acne Treatment and Skin Rejuvenation: Histological Assessment

    OpenAIRE

    Omi, Tokuya

    2012-01-01

    Background and Aims: Recent reports indicate that a variety of light-based devices have been used for acne treatment and skin rejuvenation. A new technology combining intense pulsed light with negative pressure, photopneumatic technology, has recently attracted interest. The present study assessed acne treatment and skin rejuvenation with this novel approach

  10. Framework for dementia Quality of Life assessment with Assistive Technology

    DEFF Research Database (Denmark)

    Peterson, Carrie Beth; Prasad, Neeli R.; Prasad, Ramjee

    2010-01-01

    This paper proposes a theoretical framework for a Quality of Life (QOL) evaluation tool that is sensitive, flexible, computerized, and specific to assistive technology (AT) for dementia care. Using the appropriate evaluation tool serves to improve methodologies that are used for AT assessment...... particular regard to the influx in assistive technologies and their implications as therapeutic interventions for dementia care....

  11. Lifecycle Assessment of Biofuel Production from Wood Pyrolysis Technology

    Science.gov (United States)

    Manyele, S. V.

    2007-01-01

    Due to a stronger dependency on biomass for energy, there is a need for improved technologies in biomass-to-energy conversion in Tanzania. This paper presents a life cycle assessment (LCA) of pyrolysis technology used for conversion of wood and wood waste to liquid biofuel. In particular, a survey of environmental impacts of the process is…

  12. Fissile material disposition program final immobilization form assessment and recommendation

    International Nuclear Information System (INIS)

    Lawrence Livermore National Laboratory (LLNL), in its role as the lead laboratory for the development of plutonium immobilization technologies for the Department of Energy's Office of Fissile Materials Disposition (MD), has been requested by MD to recommend an immobilization technology for the disposition of surplus weapons- usable plutonium. The recommendation and supporting documentation was requested to be provided by September 1, 1997. This report addresses the choice between glass and ceramic technologies for immobilizing plutonium using the can-in-canister approach. Its purpose is to provide a comparative evaluation of the two candidate technologies and to recommend a form based on technical considerations

  13. A needs assessment for mobile technology use in medical education

    Directory of Open Access Journals (Sweden)

    Shahrzad Vafa

    2013-11-01

    Full Text Available Objectives: This study investigated how medical students perceived mobile technology as a component of their learning experience and identified barriers to the use of mobile technology in education. Methods: An anonymous survey developed by EDUCAUSE was distributed to 1000 first year medical students (M1s at two separate medical schools during three consecutive academic years, 2010 to 2013. The 25-item questionnaire assessed student use of mobile devices, student interest in mobile technologies as they apply to education, and technology issues related to implementing mobile application in education. Results: The majority of participating M1s (n=520 indicated that they own a smartphone or a similar mobile device. More than half of M1s reported using their devices for education, primarily to download educational course materials, listen to podcasts/lectures, and access medical resource applications. Two student-identified technology issues concerning the use of mobile technology in education were ensuring better implementation of technology and faster data transmission (60. Review of qualitative data from written responses to open-ended questions highlighted three common themes: (1 the current use of mobile technology in the clinics and other institutions, (2 common technology ownership and comfort of use, and (3 efficiency and accessibility to learning materials. Conclusions: While the needs assessment revealed student acceptance of mobile technology in education, student responses highlighted the need for a supportive academic and technological infrastructure.

  14. Technology Development Risk Assessment for Space Transportation Systems

    Science.gov (United States)

    Mathias, Donovan L.; Godsell, Aga M.; Go, Susie

    2006-01-01

    A new approach for assessing development risk associated with technology development projects is presented. The method represents technology evolution in terms of sector-specific discrete development stages. A Monte Carlo simulation is used to generate development probability distributions based on statistical models of the discrete transitions. Development risk is derived from the resulting probability distributions and specific program requirements. Two sample cases are discussed to illustrate the approach, a single rocket engine development and a three-technology space transportation portfolio.

  15. Desalination with thermal solar systems: technology assessment and perspectives

    International Nuclear Information System (INIS)

    Solar desalination is among the most promising alternatives to apply solar energy as solar availability and the load requirements use to be matched. Solar thermal energy offers a full set of alternatives to desalt water, being the main difference among them the temperature range at which the load has to be fed. Solar technologies for the low temperature range (solar stills, plastic collectors,...) are quite suited for small loads in isolated placed or whenever the main constrain is to indigenize technology and to perform the operation and maintenance work with low qualified local labor, such as in less developed countries. The main drawback of this low temperature use of solar energy is that it is not possible to recover neither the heat of condensation of the water vapor, nor from the reject brine, to warm up the feed saline water. Higher temperature collectors, such as flat plate collectors with transparent insulation material and evacuated tubes, allow to work with conventional desalination units fed at 60-90C, as Multiple Effect Units or Multistage Flash Units, which get a performance ratio (quotient between heat required without recovery and with heat recovery) between 5 and 10. To further increase the performance ratio it is necessary to work with vapor in the 200C range. To attain this temperature range the solar option is based on the Parabolic Trough collector. This has been the line we have followed in our STD project in the Plataforma Solar in Almeria (Spain) when we have run a Multiple Effect Unit with an Absorption Heat Pump able to attain a performance ratio of 20. In this report, included within the STD project activities, we assess the potential of the solar thermal technology to desalt water in all the above mentioned temperature ranges. Beside the technology description and some characteristics results, we present a set of tool that, as the final result is dramatically dependent on the technical and economical scenario selected, will allow to

  16. [Health research and health technology assessment in Chile].

    Science.gov (United States)

    Espinoza, Manuel Antonio; Cabieses, Báltica; Paraje, Guillermo

    2014-01-01

    Health research is considered an essential element for the improvement of population health and it has been recommended that a share of the national health budget should be allocated to develop this field. Chile has undertaken efforts in the last decades in order to improve the governmental structure created to promote the development of health research, which has increased human resources and funding opportunities. On the other hand, the sustained economic growth of Chile in the last decades suggests that the health expenditure will maintain its increasing trend in the following years. This additional funding could be used to improve coverage of current activities performed in the health system, but also to address the incorporation of new strategies. More recently, health technology assessment (HTA) has been proposed as a process to support decisions about allocation of resources based on scientific evidence. This paper examines the relationship between the development of health research and the HTA process. First, it presents a brief diagnosis of the situation of health research in Chile. Second, it reviews the conceptual basis and the methods that account for the relationship between a HTA process and the development of health research. In particular, it emphasizes the relevance of identifying information gaps where funding additional research can be considered a good use of public resources. Finally, it discusses the challenges and possible courses of action that Chile could take in order to guarantee the continuous improvement of an articulated structure for health research and HTA. PMID:24861179

  17. Defining the "proven technology" technical criterion in the reactor technology assessment for Malaysia's nuclear power program

    Science.gov (United States)

    Anuar, Nuraslinda; Kahar, Wan Shakirah Wan Abdul; Manan, Jamal Abdul Nasir Abd

    2015-04-01

    Developing countries that are considering the deployment of nuclear power plants (NPPs) in the near future need to perform reactor technology assessment (RTA) in order to select the most suitable reactor design. The International Atomic Energy Agency (IAEA) reported in the Common User Considerations (CUC) document that "proven technology" is one of the most important technical criteria for newcomer countries in performing the RTA. The qualitative description of five desired features for "proven technology" is relatively broad and only provides a general guideline to its characterization. This paper proposes a methodology to define the "proven technology" term according to a specific country's requirements using a three-stage evaluation process. The first evaluation stage screens the available technologies in the market against a predefined minimum Technology Readiness Level (TRL) derived as a condition based on national needs and policy objectives. The result is a list of technology options, which are then assessed in the second evaluation stage against quantitative definitions of CUC desired features for proven technology. The potential technology candidates produced from this evaluation is further narrowed down to obtain a list of proven technology candidates by assessing them against selected risk criteria and the established maximum allowable total score using a scoring matrix. The outcome of this methodology is the proven technology candidates selected using an accurate definition of "proven technology" that fulfills the policy objectives, national needs and risk, and country-specific CUC desired features of the country that performs this assessment. A simplified assessment for Malaysia is carried out to demonstrate and suggest the use of the proposed methodology. In this exercise, ABWR, AP1000, APR1400 and EPR designs assumed the top-ranks of proven technology candidates according to Malaysia's definition of "proven technology".

  18. Using method triangulation to validate a new instrument (CPWQ-com) assessing cancer patients' satisfaction with communication

    DEFF Research Database (Denmark)

    Ross, Lone; Lundstrøm, Louise Hyldborg; Petersen, Morten Aagaard;

    2012-01-01

    PURPOSE: Patients' perceptions of care including the communication with health care staff is recognized as an important aspect of the quality of cancer care. Using mixed methods, we developed and validated a short instrument assessing this communication. METHODS: Based on focus group interviews...... with 77 informants, an 8-item instrument was developed. This short instrument aimed at assessing overall aspects of the communication between cancer patients and health care staff. The items were validated first through cognitive interviews with patient-observer agreement with 52 cancer patients who...... traditional cognitive interviews with 17 cancer patients. Finally, psychometric analyses took place with data from 1490 cancer patients. RESULTS: The weighted kappas concerning patient-observer agreement ranged 0.31-0.88. Disagreements mainly consisted of the observer choosing the response category indicating...

  19. Assessment of the Fusion Energy Sciences Program. Final Report

    International Nuclear Information System (INIS)

    An assessment of the Office of Fusion Energy Sciences (OFES) program with guidance for future program strategy. The overall objective of this study is to prepare an independent assessment of the scientific quality of the Office of Fusion Energy Sciences program at the Department of Energy. The Fusion Science Assessment Committee (FuSAC) has been appointed to conduct this study

  20. Questionnaire for the contents of cancer professional training plan by Ministry of Education, Culture, Sports, Science, and Technology Japan

    International Nuclear Information System (INIS)

    Questionnaire for the contents of cancer professional training plan by Ministry of Education, Culture, Sports, Science, and Technology Japan were widely assessed and introduced in the 4th Japanese Society for Therapeutic Radiology and Oncology (JASTRO) Future Planning Seminar held on March 8, 2008 in Tokyo, Japan. From the assessment, small number of instructors for medical physicists was elucidated as the most important problem for the future of fields of radiation oncology in Japan. (author)

  1. Technology assessment of geothermal energy resource development

    Energy Technology Data Exchange (ETDEWEB)

    1975-04-15

    Geothermal state-of-the-art is described including geothermal resources, technology, and institutional, legal, and environmental considerations. The way geothermal energy may evolve in the United States is described; a series of plausible scenarios and the factors and policies which control the rate of growth of the resource are presented. The potential primary and higher order impacts of geothermal energy are explored, including effects on the economy and society, cities and dwellings, environmental, and on institutions affected by it. Numerical and methodological detail is included in appendices. (MHR)

  2. Contact radiotherapy. Report of technological assessment

    International Nuclear Information System (INIS)

    This report aims at assessing safety, indications, the role in therapeutic strategy, and efficiency of contact radiotherapy. It also aims at answering questions like: is the contact radiotherapy technique validated? What are the indications for contact radiotherapy? What about the efficiency and safety of contact radiotherapy? After a presentation of preliminary notions on radiotherapy (radiation types, dose, and irradiation techniques), the report presents this specific technique of contact radiotherapy: definition, devices, use recommendations, issues of radiation protection, modalities of performance of a contact radiotherapy session, and concerned pathologies. Then, based on a literature survey, this report addresses the various concerned tumours (skin, rectum, brain, breast), indicates some general information about these tumours (epidemiological data, anatomy and classification, therapeutic options, radiotherapy), and proposes an assessment of the efficiency and safety of contact radiotherapy

  3. Advanced turbine systems sensors and controls needs assessment study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, R.L.; Fry, D.N.; McEvers, J.A.

    1997-02-01

    The Instrumentation and Controls Division of the Oak Ridge National Laboratory performed an assessment of the sensors and controls needs for land-based advanced gas turbines being designed as a part of the Department of Energy`s (DOE`s) Advanced Turbine Systems (ATS) Program for both utility and industrial applications. The assessment included visits to five turbine manufacturers. During these visits, in-depth discussions were held with design and manufacturing staff to obtain their views regarding the need for new sensors and controls for their advanced turbine designs. The Unsteady Combustion Facilities at the Morgantown Energy Technology Center was visited to assess the need for new sensors for gas turbine combustion research. Finally, a workshop was conducted at the South Carolina Energy Research and Development Center which provided a forum for industry, laboratory, and university engineers to discuss and prioritize sensor and control needs. The assessment identified more than 50 different measurement, control, and monitoring needs for advanced turbines that cannot currently be met from commercial sources. While all the identified needs are important, some are absolutely critical to the success of the ATS Program.

  4. Assessing cognitive function and capacity in older adults with cancer.

    Science.gov (United States)

    McKoy, June M; Burhenn, Peggy S; Browner, Ilene S; Loeser, Kari L; Tulas, Katrina M; Oden, Megan R; Rupper, Randall W

    2014-01-01

    The number of older individuals with cancer is increasing exponentially, mandating that oncologists contemplate more comprehensive and multidisciplinary approaches to treatment of this cohort. Recruitment of assessment instruments validated in older patients can be invaluable for guiding treatment and decision-making by both patients and providers, and can arguably contribute to improving outcomes and health-related quality of life. The Comprehensive Geriatric Assessment is one such validated instrument that can be used by oncologists to assess patient readiness and appropriateness for prescribed cancer therapy. As a multidisciplinary diagnostic and treatment process, it comprises functional status, cognitive status, social support, and advance care preferences, and is an ideal instrument for evaluating complex older individuals. It is well established that many older individuals with cancer travel with multiple comorbid illnesses, including cognitive impairment, and when presented with a cancer diagnosis struggle to choose from multiple treatment options. In addition to the complete medical history, the ability of patients to decide on a course of therapy in concert with their oncologist is critically important. Alternatively, many oncologists are conflicted as to whether true informed consent for treatment can be obtained from many older patients. Having a roadmap to decision-making capacity is therefore an inescapable imperative in geriatric oncology, because careful attention must be directed at identifying older patients with cancer who might benefit from these assessments and the individualized treatment plans that emerge. PMID:24453297

  5. Problems of method of technology assessment. A methodological analysis; Methodenprobleme des Technology Assessment; Eine methodologische Analyse

    Energy Technology Data Exchange (ETDEWEB)

    Zimmermann, V.

    1993-03-01

    The study undertakes to analyse the theoretical and methodological structure of Technology Assessment (TA). It is based on a survey of TA studies which provided an important condition for theoreticall sound statements on methodological aspects of TA. It was established that the main basic theoretical problems of TA are in the field of dealing with complexity. This is also apparent in the constitution of problems, the most elementary and central approach of TA. Scientifically founded constitution of problems and the corresponding construction of models call for interdisciplinary scientific work. Interdisciplinarity in the TA research process is achieved at the level of virtual networks, these networks being composed of individuals suited to teamwork. The emerging network structures have an objective-organizational and an ideational basis. The objective-organizational basis is mainly the result of team composition and the external affiliations of the team members. The ideational basis of the virtual network is represented by the team members` mode of thinking, which is individually located at a multidisciplinary level. The theoretical `skeleton` of the TA knowledge system, which is represented by process knowledge based linkage structures, can be generated and also processed in connection with the knowledge on types of problems, areas of analysis and procedures to deal with complexity. Within this process, disciplinary knowledge is a necessary but not a sufficient condition. Metatheoretical and metadisciplinary knowledge and the correspondingly processes complexity of models are the basis for the necessary methodological awareness, that allows TA to become designable as a research procedure. (orig./HP) [Deutsch] Die Studie stellt sich die Aufgabe, die theoretische und methodische Struktur des Technology Assessment (TA) zu analysieren. Sie fusst auf Erhebungen, die bei Technology-Assessment-Studien vorgenommen wurden und die wesentliche Voraussetzungen fuer

  6. Frameworks for Hospital-Based Health Technology Assessment to Resolve Financial Issues in South Korea

    Directory of Open Access Journals (Sweden)

    Jiwon Yang

    2016-06-01

    Full Text Available Objectives: The aim was to design frameworks and develop a detailed process regarding Hospital-Based Health Technology Assessment (HB-HTA in South Korea. Methods: We conducted a literature review and interviewed in writing or in person experts to assess the need for and existing types of HB-HTA. Results: HB-HTA in advanced countries can be classified into four types according to the condition of hospitals and type of assessment. Further, the expert interviews revealed the necessity of HB-HTA for the efficient introduction of new health technologies and financial cost reduction in hospitals. Finally, three ideal HB-HTA models for use in South Korea were suggested as part of the identified framework: an education and dissemination model, a governmenthospital joint research model, and a self-research model. Conclusions: The suggested three models will contribute to the provision of safe, effective, and cost-effective health technologies and efficient resources allocation in hospitals.

  7. Particle radiotherapy emerging technology for treatment of cancer

    CERN Document Server

    Sahoo, Narayan

    2016-01-01

    The results of decades of research and development are providing compelling evidence about the efficacy of radiation therapy with proton and carbon ion beams to achieve superior complication free tumor control leading to a world-wide rapid growth in their clinical use. This book contains comprehensive reviews of the state of the art of the technology and physics of heavy charge particle therapy by the experts from the leading cancer centers of world that will be valuable as a practical guide for radiation therapy professionals interested in these modalities.

  8. Approaches to cancer assessment in EPA's Integrated Risk Information System

    International Nuclear Information System (INIS)

    The U.S. Environmental Protection Agency's (EPA) Integrated Risk Information System (IRIS) Program develops assessments of health effects that may result from chronic exposure to chemicals in the environment. The IRIS database contains more than 540 assessments. When supported by available data, IRIS assessments provide quantitative analyses of carcinogenic effects. Since publication of EPA's 2005 Guidelines for Carcinogen Risk Assessment, IRIS cancer assessments have implemented new approaches recommended in these guidelines and expanded the use of complex scientific methods to perform quantitative dose-response assessments. Two case studies of the application of the mode of action framework from the 2005 Cancer Guidelines are presented in this paper. The first is a case study of 1,2,3-trichloropropane, as an example of a chemical with a mutagenic mode of carcinogenic action thus warranting the application of age-dependent adjustment factors for early-life exposure; the second is a case study of ethylene glycol monobutyl ether, as an example of a chemical with a carcinogenic action consistent with a nonlinear extrapolation approach. The use of physiologically based pharmacokinetic (PBPK) modeling to quantify interindividual variability and account for human parameter uncertainty as part of a quantitative cancer assessment is illustrated using a case study involving probabilistic PBPK modeling for dichloromethane. We also discuss statistical issues in assessing trends and model fit for tumor dose-response data, analysis of the combined risk from multiple types of tumors, and application of life-table methods for using human data to derive cancer risk estimates. These issues reflect the complexity and challenges faced in assessing the carcinogenic risks from exposure to environmental chemicals, and provide a view of the current trends in IRIS carcinogenicity risk assessment.

  9. Technologies for Interactive Learning and Assessment Content Development

    Science.gov (United States)

    Gusev, Marjan; Ristov, Sasko; Armenski, Goce

    2016-01-01

    Recent technology trends evolved the student assessment from traditional ones ("pen-and-paper" and "face-to-face") to modern e-Assessment system. These modern approaches allow the teachers to conduct and evaluate an exam with huge number of students in a short period of time. Even more important, both the teacher and the…

  10. Technology Enhanced Formative Assessment for 21st Century Learning

    Science.gov (United States)

    Spector, J. Michael; Ifenthaler, Dirk; Sampson, Demetrios; Yang, Lan; Mukama, Evode; Warusavitarana, Amali; Dona, Kulari Lokuge; Eichhorn, Koos; Fluck, Andrew; Huang, Ronghuai; Bridges, Susan; Lu, Jiingyan; Ren, Youqun; Gui, Xiaoqing; Deneen, Christopher C.; San Diego, Jonathan; Gibson, David C.

    2016-01-01

    This paper is based on the deliberations of the Assessment Working Group at EDUsummIT 2015 in Bangkok, Thailand. All of the members of Thematic Working Group 5 (TWG5) have contributed to this synthesis of potentials, concerns and issues with regard to the role of technology in assessment as, for and of learning in the 21st century. The group…

  11. Utilisation of medical technology assessment in health policy

    NARCIS (Netherlands)

    van den Heuvel, WJA; Wieringh, R; van den Heuvel, LPM

    1997-01-01

    Objective: To assess the contribution of medical technology assessment (MTA) to health policy decision making, the question has to be answered whether MTA is actually being used in decision-making processes and what factors are related to its utilisation. Design: We investigated recent Dutch policy

  12. Voice Assessment of Student Work: Recent Studies and Emerging Technologies

    Science.gov (United States)

    Eckhouse, Barry; Carroll, Rebecca

    2013-01-01

    Although relatively little attention has been given to the voice assessment of student work, at least when compared with more traditional forms of text-based review, the attention it has received strongly points to a promising form of review that has been hampered by the limits of an emerging technology. A fresh review of voice assessment in light…

  13. Speech Technology-Based Assessment of Phoneme Intelligibility in Dysarthria

    Science.gov (United States)

    Van Nuffelen, Gwen; Middag, Catherine; De Bodt, Marc; Martens, Jean-Pierre

    2009-01-01

    Background: Currently, clinicians mainly rely on perceptual judgements to assess intelligibility of dysarthric speech. Although often highly reliable, this procedure is subjective with a lot of intrinsic variables. Therefore, certain benefits can be expected from a speech technology-based intelligibility assessment. Previous attempts to develop an…

  14. Space-reactor electric systems: subsystem technology assessment

    International Nuclear Information System (INIS)

    This report documents the subsystem technology assessment. For the purpose of this report, five subsystems were defined for a space reactor electric system, and the report is organized around these subsystems: reactor; shielding; primary heat transport; power conversion and processing; and heat rejection. The purpose of the assessment was to determine the current technology status and the technology potentials for different types of the five subsystems. The cost and schedule needed to develop these potentials were estimated, and sets of development-compatible subsystems were identified

  15. Space-reactor electric systems: subsystem technology assessment

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, R.V.; Bost, D.; Determan, W.R.

    1983-03-29

    This report documents the subsystem technology assessment. For the purpose of this report, five subsystems were defined for a space reactor electric system, and the report is organized around these subsystems: reactor; shielding; primary heat transport; power conversion and processing; and heat rejection. The purpose of the assessment was to determine the current technology status and the technology potentials for different types of the five subsystems. The cost and schedule needed to develop these potentials were estimated, and sets of development-compatible subsystems were identified.

  16. Application of phage display technology in targeted therapy of breast cancer

    Institute of Scientific and Technical Information of China (English)

    Mian Kong; Junye Wang; Baojiang Li

    2013-01-01

    Phage display is a technology of gene expression and screening, it is widely used in the fields of defining antigenepitopes, signal transduction, genetic treatment, parasites research and tumor targeted therapy. Breast cancer is the mostcommon cancer in women, we can obtain peptides specially associated with breast cancer by using phage display technology,and this method has great potential in early diagnosis of breast cancer and development new targeted drugs.

  17. Cancer Nano technology Using Elastin-Like Polypeptides

    International Nuclear Information System (INIS)

    Despite progress in understanding cancer biology, this knowledge has not translated into comparable advances in the clinic. Two fundamental problems currently stalling the efficient treatment of cancer have been detecting cancer early enough for successful treatment and avoiding excessive toxicity to normal tissues. In view of this, cancer still remains one of the leading causes of mortality worldwide, affecting over 10 million new patients every year. Clearly the development of novel approaches for early detection and treatment of cancer is urgently needed to increase patient survival. Recently, nano technology-based systems have emerged as novel therapeutic modalities for cancer treatment. Tiny man made nanoparticles, much smaller than a virus, are being developed to package, transport, and deliver imaging and therapeutic agents. Co-inclusion of these agents, into nano carriers might be advantageous because they increase solubility of hydrophobic drugs, enhance permeability across physiological barriers, alter drug biodistribution, increase local bioavailability and reduce side effects. Initial findings have been promising and nanoparticles have been shown to deliver therapeutic agents to target cells and effect tumor growth. To this end our lab is investigating a class of biodegradable and biocompatible polymers known as elastin-like polypeptides (ELP). Elastin like polypeptide is a bio polymer derived from the structural motif found in mammalian elastin protein and has a sequence dependent transition temperature that can be used as nano carriers to treat diseases. ELPs are characterized by the pentameric repeat VPGXG, where X can be any amino acid. All functional ELPs undergo inverse phase transition whereby below its transition temperature, they exist in a solubilized form while above its transition temperature they undergo phase separation which leads to their aggregation in solution. This process is reversible. Phase transition can also be triggered by other

  18. Health Technology Assessment of Integrated Home Care

    DEFF Research Database (Denmark)

    Larsen, Torben

    2012-01-01

    Background: The fragmented delivery of healthcare and social services as advanced by WHO 2002. Objectives: This project of international collaboration assesses integrated home care (IHC) for frail elder somatic patients as compared to usual hospital care. Methods: The HTA follows the special......-up: Stroke: A meta-analysis including 14 randomized trials (N=2139) demonstrate a significant reduction (p< 0.001) in the risk being dead or dependent compared with conventional care with OR=0.75 (CI95%: 0.61-0.92). HF: 3 RCT (N=568) demonstrate each a significant reduction of all-cause readmissions. A meta...

  19. Evaluation of technology transferring: The experiences of the first Navy Domestic Technology Transfair. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1989-12-31

    In August 1989 the Office of the Chief of Naval Research and the American Defense Preparedness Association conducted the first Navy Domestic Technology Transfair. The objective of the Transfair was to expose the US Navy`s years of solid experience across a broad span of technology to organizations outside of the Navy. It was an opportunity for private industry to capitalize on the Navy developed technology and this opening for industry was the primary focus of the Transfair. The event provided a unique forum to meet leading Navy scientific and engineering innovators face-to-face. Information was available concerning licensing of naval technology that was for sale to the private sector. Further, discussions covered opportunities for new cooperative research and development agreements with Navy laboratories and R&D activities. These agreements were authorized under the Federal Technology Transfer Act of 1986. The Transfair program was conducted in such a manner as to allow each Navy inventor, either scientist or engineer, to present a system, piece of hardware, or licensable concept in a formal paper presentation. Then, the Navy inventors were available in two, two-hour periods in which individual discussions were conducted, with attendees pursuing specific venues of cooperative agreements as desired. This report provides specifics concerning the technologies that were made available for transfer to the private sector during the Transfair. The Transfair concept sought to add special emphasis to the opening that the 1988 Technology Transfer Act brought to the marketplace. The experience was a step in the education of the possibilities for cooperation between the government and the private sector to share technology. Of additional significance is the economic enhancement for business expansion with the application of the technology to markets beyond defense.

  20. Assessment of Breast Cancer Risk and Belief in Breast Cancer Screening Among the Primary Healthcare Nurses.

    Science.gov (United States)

    İz, Fatma Başalan; Tümer, Adile

    2016-09-01

    Breast cancer is the most frequently diagnosed cancer in women. Early detection of breast cancer is known to increase survival rates significantly after diagnosis. This research was carried out to determine the level of breast cancer risk among primary healthcare nurses and their belief in breast cancer screening. In this descriptive research, the data were collected in face-to-face interviews with the participants. The researchers contacted all primary healthcare nurses currently working in the province. The data collection tools included a questionnaire form on sociodemographic characteristics, breast cancer risk assessment form, and Champion's Health Belief Model Scale (CHBMS) for breast cancer screening. In data analysis, descriptive statistics, t test, and analysis of variance (ANOVA) were used. The mean age of nurses was 35 ± 3.6. The mean score for the breast cancer risk assessment form was calculated as 82.9 ± 18.7. The subscale scores for the CHBMS for breast cancer screening were as follows: susceptibility 7.3 ± 1.8, seriousness 19.5 ± 4.1, benefits of breast self-exam 15.5 ± 2.6, barriers to breast self-exam 15.1 ± 2.8, self-efficacy 40.3 ± 7.0, and motivation 19.5 ± 4.1. The risk of breast cancer was found to be low in the study group. The analysis of the subscale scores for the CHBMS for breast cancer screening revealed that nurses had a below-average susceptibility perception, a somewhat lower perception of seriousness, an above-average mean score for perceived benefits, a moderate barrier perception, a relatively high perceived self-efficacy, and motivation above average. PMID:26758047

  1. Multiple Intelligences: Curriculum and Assessment Project. Final Report

    Science.gov (United States)

    Hyland, Aine, Ed.

    2011-01-01

    The "Multiple Intelligences, Curriculum and Assessment Project" at University College Cork was a collaborative project carried out between 1995 and 1999. The key research question focused on whether Howard Gardner's theory of Multiple Intelligences could be applied to, and enhance, aspects of curriculum and assessment at primary and second level…

  2. Reactor technology assessment and selection utilizing systems engineering approach

    International Nuclear Information System (INIS)

    Full-text: The first Nuclear power plant (NPP) deployment in a country is a complex process that needs to consider technical, economic and financial aspects along with other aspects like public acceptance. Increased interest in the deployment of new NPPs, both among newcomer countries and those with expanding programs, necessitates the selection of reactor technology among commercially available technologies. This paper reviews the Systems Decision Process (SDP) of Systems Engineering and applies it in selecting the most appropriate reactor technology for the deployment in Malaysia. The integrated qualitative and quantitative analyses employed in the SDP are explored to perform reactor technology assessment and to select the most feasible technology whose design has also to comply with the IAEA standard requirements and other relevant requirements that have been established in this study. A quick Malaysian case study result suggests that the country reside with PWR (pressurized water reactor) technologies with more detailed study to be performed in the future for the selection of the most appropriate reactor technology for Malaysia. The demonstrated technology assessment also proposes an alternative method to systematically and quantitatively select the most appropriate reactor technology. (author)

  3. Evaluation of technology modifications required to apply clean coal technologies in Russian utilities. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-01

    The report describes the following: overview of the Russian power industry; electric power equipment of Russia; power industry development forecast for Russia; clean coal technology demonstration program of the US Department of Energy; reduction of coal TPS (thermal power station) environmental impacts in Russia; and base options of advanced coal thermal power plants. Terms of the application of clean coal technology at Russian TPS are discussed in the Conclusions.

  4. Idaho National Laboratory Technology to Market (T2M) Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Wright, Christopher Todd [Idaho National Lab. (INL), Idaho Falls, ID (United States); Bush, Jason William [Idaho National Lab. (INL), Idaho Falls, ID (United States); Gentle, Jake Paul [Idaho National Lab. (INL), Idaho Falls, ID (United States); Hill, Porter Jack [Idaho National Lab. (INL), Idaho Falls, ID (United States); Myers, Kurt Steven [Idaho National Lab. (INL), Idaho Falls, ID (United States); Williams, Christopher Luke [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-01-01

    The objective of this project is to establish a tiered Technology to Market (T2M) curriculum for basic researchers to project leads to measure the effect of technology transfer skills on project success and impact. The plan will train five researchers in basic technology transfer principles where success will be measured by assessing improvements in T2M skills and knowledge after the training is complete, likely using before and after surveys.

  5. Thermophotovoltaic (TPV) technology development. Final report, May 15, 1995--December 1, 1995

    International Nuclear Information System (INIS)

    This program information release (PIR) summarizes work performed under Task Order Contract SF17787, Task Order 18: Thermophotovoltaic Technology Development, sponsored by the U.S. Department of Energy. The period of performance was 15 May 1995 to 1 December 1995. Under this task order, a system model for a thermophotovoltaic (MV) converter was implemented and used to compare a conceptual design for an advanced quaternary III-V cell with integral filter with results previously published for a binary GaSb cell with a freestanding filter. Model results were used to assess the merits of TPV conversion for meeting various levels of space power requirements, including low to medium power isotope applications and high-power reactor applications. A TPV cell development program was initiated to determine the feasibility of fabricating quaternary III-V cells by molecular beam epitaxy. Lastly, a conceptual design was completed for a low-cost demonstration system to test the performance of TPV converters at a multi-cell, sub-system level. The results of these efforts are reported briefly in an executive summary, then in somewhat more detail as a final briefing section in which charts have been reproduced. Additional technical detail is provided in the appendices

  6. Genetic Assessment of Breast Cancer Risk in Primary Care Practice

    OpenAIRE

    Burke, Wylie; Culver, Julie; Pinsky, Linda; Hall, Sarah; Reynolds, Susan E; Yasui, Yutaka; Press, Nancy

    2009-01-01

    Family history is increasingly important in primary care as a means to detect candidates for genetic testing or tailored prevention programs. We evaluated primary care physicians’ skills in assessing family history for breast cancer risk, using unannounced standardized patient visits to 86 general internists and family medicine practitioners in King County, WA. Transcripts of clinical encounters were coded to determine ascertainment of family history, risk assessment, and clinical follow-up. ...

  7. Shuttle Ground Operations Efficiencies/Technologies (SGOE/T) study. Volume 3: Final presentation material

    Science.gov (United States)

    Scholz, A. L.; Hart, M. T.; Lowry, D. J.

    1987-01-01

    Charts used in the Final Phase 1 Oral Briefing at Kennedy Space Center on April 6, 1987, and to the Space Transportation Architecture Study (SPAS) Interim Program Review (IPS-5) held at MSFC on April 8, 1987, are contained. Topics discussed include: identification of existing or new technologies to reduce cost; management approaches; recommendations for research or development of specific technology for future use; and identification of new management techniques.

  8. Serological assessment of gastric mucosal atrophy in gastric cancer

    Directory of Open Access Journals (Sweden)

    Bornschein Jan

    2012-01-01

    Full Text Available Abstract Background Non-invasive tools for gastric cancer screening and diagnosis are lacking. Serological testing with the detection of pepsinogen 1 (PG1, pepsinogen 2 (PG2 and gastrin 17 (G17 offers the possibility to detect preneoplastic gastric mucosal conditions. Aim of this study was to assess the performance of these serological tests in the presence of gastric neoplasia. Methods Histological and serological samples of 118 patients with gastric cancer have been assessed for tumor specific characteristics (Laurén type, localisation, degree of mucosal abnormalities (intestinal metaplasia, atrophy and serological parameters (PG1, PG2, PG1/2-ratio, G17, H. pylori IgG, CagA status. Association of the general factors to the different serological values have been statistically analyzed. Results Patients with intestinal type gastric cancer had lower PG1 levels and a lower PG1/2-ratio compared to those with diffuse type cancer (p = 0.003. The serum levels of PG2 itself and G17 were not significantly altered. H. pylori infection in general had no influence on the levels of PG1, PG2 and G17 in the serum of gastric cancer patients. There was a trend towards lower PG1 levels in case of positive CagA-status (p = 0.058. The degree of both intestinal metaplasia and atrophy correlated inversely with serum levels for PG1 and the PG1/2-ratio (p Conclusions Glandular atrophy and a positive CagA status are determinant factors for decreased pepsinogen 1 levels in the serum of patients with gastric cancer. The serological assessment of gastric atrophy by analysis of serum pepsinogen is only adequate for patients with intestinal type cancer.

  9. Integrated assessment of emerging science and technologies as creating learning processes among assessment communities.

    Science.gov (United States)

    Forsberg, Ellen-Marie; Ribeiro, Barbara; Heyen, Nils B; Nielsen, Rasmus Øjvind; Thorstensen, Erik; de Bakker, Erik; Klüver, Lars; Reiss, Thomas; Beekman, Volkert; Millar, Kate

    2016-12-01

    Emerging science and technologies are often characterised by complexity, uncertainty and controversy. Regulation and governance of such scientific and technological developments needs to build on knowledge and evidence that reflect this complicated situation. This insight is sometimes formulated as a call for integrated assessment of emerging science and technologies, and such a call is analysed in this article. The article addresses two overall questions. The first is: to what extent are emerging science and technologies currently assessed in an integrated way. The second is: if there appears to be a need for further integration, what should such integration consist in? In the article we briefly outline the pedigree of the term 'integrated assessment' and present a number of interpretations of the concept that are useful for informing current analyses and discussions of integration in assessment. Based on four case studies of assessment of emerging science and technologies, studies of assessment traditions, literature analysis and dialogues with assessment professionals, currently under-developed integration dimensions are identified. It is suggested how these dimensions can be addressed in a practical approach to assessment where representatives of different assessment communities and stakeholders are involved. We call this approach the Trans Domain Technology Evaluation Process (TranSTEP). PMID:27465504

  10. Technology assessment - a workable way out of the 'risk society'?

    International Nuclear Information System (INIS)

    On the basis of concrete experience and results in the risk assessment process concerning nuclear technology in the Federal Republic of Germany it becomes apparent that technology asessment can make a contribution towards the required technology domestication. The 'risk management' of the circle of nuclear power generators and the consulting and licensing bodies having failed, a new phase of technology assessment began in 1970, whereby proponents and opponents of nuclear energy had a say. Parallel research on the safety of light water reactors and fast breeders gave valuable insight into the danger potential of nuclear energy while the latent risk of technology assessment misuse became apparent in the decision-finding process concerning the problem of radioactive waste management. In the end it were the Enquete Commission 'Future Nuclear Energy Policy' of the German Bundestag and the studies on social agreeability of energy supply systems which resulted in the perspective of a future without the use of nuclear power being a realistic option. The general findings of technology assessment, e.g. the cognition that there can be no scientific decision in favour of assuming responsibility for nuclear energy, opens up new views and possibilities for acting for the decision-makers in the field of energy policy. (orig./HSCH)

  11. How to make participatory technology assessment in agriculture more 'participatory'

    DEFF Research Database (Denmark)

    Tavella, Elena

    2016-01-01

    the cultivation of new GM plants in Denmark. Furthermore, through this illustration, the term Participatory Technology Assessment (PTA) is redefined, thereby suggesting two additional aspects to assessing new technologies – following and evaluating policy making – to be considered in the conduct of......This paper suggests a framework, based on Critical Systems Heuristics (CSH), to guide the organisation and management of expert-facilitated and participatory processes that allow for stakeholders' different interests, concerns, and values to be included in the assessment and policy making of GM...... plants. The framework is particularly useful for stakeholders, such as governments, foundations, and researchers, who attempt to facilitate inclusive and democratic processes to assess GM plants. The use of the framework is illustrated by evaluating the report from a citizen jury carried out to assess...

  12. Social impact assessment: A review and proposed approach: Final report

    Energy Technology Data Exchange (ETDEWEB)

    Bradbury, J A

    1986-12-01

    The objective of the report is to identify the essential components of a comprehensive plan to assess the potential social impacts of the proposed construction and operation of a high level radioactive waste repository by the Nevada Nuclear Waste Storage Investigations (NNWSI) Project. The tasks taken to achieve this objective are: examination of the literature on Social Impact Assessment (SIA); identification of different conceptual frameworks that have been proposed or used in SIA; examination of specific aspects of the frameworks; assessment of strengths and weaknesses of the frameworks; synthesis of common elements in these frameworks; and examination and evaluation of methods of data collection and analysis. 150 refs., 6 figs., 7 tabs.

  13. Social impact assessment: A review and proposed approach: Final report

    International Nuclear Information System (INIS)

    The objective of the report is to identify the essential components of a comprehensive plan to assess the potential social impacts of the proposed construction and operation of a high level radioactive waste repository by the Nevada Nuclear Waste Storage Investigations (NNWSI) Project. The tasks taken to achieve this objective are: examination of the literature on Social Impact Assessment (SIA); identification of different conceptual frameworks that have been proposed or used in SIA; examination of specific aspects of the frameworks; assessment of strengths and weaknesses of the frameworks; synthesis of common elements in these frameworks; and examination and evaluation of methods of data collection and analysis. 150 refs., 6 figs., 7 tabs

  14. Final Addendum to the Necedah National Wildlife Refuge Environmental Assessment

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of this Addendum is to clarify actions that will be taken under the selected alternative for the Fire Management Plan Environmental Assessment that was...

  15. Optical transillumination spectroscopy of breast tissue for cancer risk assessment

    Science.gov (United States)

    Lilge, Lothar; Blyschak, Kristina; Simick, Michelle; Jong, Roberta A.

    2003-10-01

    Breast cancer is the most commonly occurring cancer in women. The lifetime risk of being diagnosed with breast cancer is approximately 1 in 10 thereby the highest out of all cancers. Breast cancer screening programs have been shown to decrease the mortality rates of women between ages 50-69, since cancers are detected at an earlier, more favourable stage. It is apparent that the development of breast cancer is a slow process following initial transformation of the breast tissue. Hence, there has been a strong effort within the research community to understand risk factors for the disease. Risk factors are defined as those characteristics that are more common in people with the disease when compared to the normal population. Quantification of an individual's breast cancer rate may lead that individual to modify her lifestyle and/or diet. Lifestyle changes could lead to a reduction in the incidence of breast cancer. Anatomically, the presence of increased amounts of fibroglandular tissue raises the estimated risk by up to 6 fold (correct for age), hence representing one of the strongest known risk factors pertaining to the entire female population. In this study the relative area of mammographic densities within a mammogram will be used as a global risk assessment tool. It has been shown previously that quantification of water, lipids, haemoglobin and other tissue chromophores of the optically interrogated breast tissue, which also gives rise to the mammographic densities, is feasible through near-infrared spectroscopy. Thus, the hypothesis for this study is that optical transillumination spectroscopy provides consistent and/or complementary information to conventional mammography in quantifying breast tissue density.

  16. The New Mexico Technology Deployment Pilot Project: A technology reinvestment project. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-01

    The New Mexico Technology Deployment Project (NMTDP) has been in operation for slightly more than two years. As one of the original TRP projects, NMTDP had the charter to develop and validate a new model for technology extraction which emphasized focused technology collaboration, early industry involvement, and a strong dual use commercialization and productization emphasis. Taken in total, the first two years of the NMTDP have been exceptionally successful, surpassing the goals of the project. This report describes the accomplishments and evolution of the NMTDP to date and discusses the future potential of the project. Despite the end of federal funding, and a subsequent reduction in level of effort, the project partners are committed to continuation of the project.

  17. Esophageal Cancer: Role of Imaging in Primary Staging and Response Assessment Post Neoadjuvant Therapy.

    Science.gov (United States)

    Griffin, Yvette

    2016-08-01

    Advances in the early detection and treatment of esophageal cancer have meant improved survival rates for patients with esophageal cancer. Accurate pretreatment and post-neoadjuvant treatment staging of esophageal cancer is essential for assessing operability and determining the optimum treatment plan. This article reviews the multimodality imaging approach in the diagnosis, staging, and assessment of treatment response in esophageal cancer. PMID:27342898

  18. Nevada low-temperaure geothermal resource assessment: 1994. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Garside, L.J.

    1994-12-31

    Data compilation for the low-temperature program is being done by State Teams in two western states. Final products of the study include: a geothermal database, in hardcopy and as digital data (diskette) listing information on all known low- and moderate- temperature springs and wells in Nevada; a 1:1,000,000-scale map displaying these geothermal localities, and a bibliography of references on Nevada geothermal resources.

  19. Technological and life cycle assessment of organics processing odour control technologies

    Energy Technology Data Exchange (ETDEWEB)

    Bindra, Navin [School of Engineering, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G2W1 (Canada); Dubey, Brajesh, E-mail: bkdubey@civil.iitkgp.ernet.in [School of Engineering, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G2W1 (Canada); Environmental Engineering Division, Department of Civil Engineering, Indian Institute of Technology, Kharagpur, West Bengal 721302 (India); Dutta, Animesh [School of Engineering, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G2W1 (Canada)

    2015-09-15

    As more municipalities and communities across developed world look towards implementing organic waste management programmes or upgrading existing ones, composting facilities are emerging as a popular choice. However, odour from these facilities continues to be one of the most important concerns in terms of cost & effective mitigation. This paper provides a technological and life cycle assessment of some of the different odour control technologies and treatment methods that can be implemented in organics processing facilities. The technological assessment compared biofilters, packed tower wet scrubbers, fine mist wet scrubbers, activated carbon adsorption, thermal oxidization, oxidization chemicals and masking agents. The technologies/treatment methods were evaluated and compared based on a variety of operational, usage and cost parameters. Based on the technological assessment it was found that, biofilters and packed bed wet scrubbers are the most applicable odour control technologies for use in organics processing faculties. A life cycle assessment was then done to compare the environmental impacts of the packed-bed wet scrubber system, organic (wood-chip media) bio-filter and inorganic (synthetic media) bio-filter systems. Twelve impact categories were assessed; cumulative energy demand (CED), climate change, human toxicity, photochemical oxidant formation, metal depletion, fossil depletion, terrestrial acidification, freshwater eutrophication, marine eutrophication, terrestrial eco-toxicity, freshwater eco-toxicity and marine eco-toxicity. The results showed that for all impact categories the synthetic media biofilter had the highest environmental impact, followed by the wood chip media bio-filter system. The packed-bed system had the lowest environmental impact for all categories. - Highlights: • Assessment of odour control technologies for organics processing facilities. • Comparative life cycle assessment of three odour control technologies was conducted

  20. Technological and life cycle assessment of organics processing odour control technologies

    International Nuclear Information System (INIS)

    As more municipalities and communities across developed world look towards implementing organic waste management programmes or upgrading existing ones, composting facilities are emerging as a popular choice. However, odour from these facilities continues to be one of the most important concerns in terms of cost & effective mitigation. This paper provides a technological and life cycle assessment of some of the different odour control technologies and treatment methods that can be implemented in organics processing facilities. The technological assessment compared biofilters, packed tower wet scrubbers, fine mist wet scrubbers, activated carbon adsorption, thermal oxidization, oxidization chemicals and masking agents. The technologies/treatment methods were evaluated and compared based on a variety of operational, usage and cost parameters. Based on the technological assessment it was found that, biofilters and packed bed wet scrubbers are the most applicable odour control technologies for use in organics processing faculties. A life cycle assessment was then done to compare the environmental impacts of the packed-bed wet scrubber system, organic (wood-chip media) bio-filter and inorganic (synthetic media) bio-filter systems. Twelve impact categories were assessed; cumulative energy demand (CED), climate change, human toxicity, photochemical oxidant formation, metal depletion, fossil depletion, terrestrial acidification, freshwater eutrophication, marine eutrophication, terrestrial eco-toxicity, freshwater eco-toxicity and marine eco-toxicity. The results showed that for all impact categories the synthetic media biofilter had the highest environmental impact, followed by the wood chip media bio-filter system. The packed-bed system had the lowest environmental impact for all categories. - Highlights: • Assessment of odour control technologies for organics processing facilities. • Comparative life cycle assessment of three odour control technologies was conducted

  1. Department of Energy--appropriate technology small grants program: final rule.

    Science.gov (United States)

    1980-02-01

    This rule prescribes amendments to the Program Guidelines for the Appropriate Technology Small Grants Program which were issued pursuant to the Energy Research and Development Administration Appropriation Authorization of 1977. The full text of Part 470, as amended, is set forth in this final rule. PMID:10247837

  2. Theoretical Assessment of Technological Potential of Magnetic and Electrical Separation

    OpenAIRE

    Karmazin, V. V.

    1997-01-01

    Magnetic, electrical an combined methods of mineral beneficiation are widely used in various branches of mining industry. These processes have significant economic and ecological advantages in those areas where they can be applied technologically. It is thus necessary to analyse technological possibilities and areas of potential applications. Different designs of the separators must also be considered. Such an attempt is being done in this article based on the assessment of the level of diffe...

  3. Computer-aided Detection of Prostate Cancer with MRI: Technology and Applications.

    Science.gov (United States)

    Liu, Lizhi; Tian, Zhiqiang; Zhang, Zhenfeng; Fei, Baowei

    2016-08-01

    One in six men will develop prostate cancer in his lifetime. Early detection and accurate diagnosis of the disease can improve cancer survival and reduce treatment costs. Recently, imaging of prostate cancer has greatly advanced since the introduction of multiparametric magnetic resonance imaging (mp-MRI). Mp-MRI consists of T2-weighted sequences combined with functional sequences including dynamic contrast-enhanced MRI, diffusion-weighted MRI, and magnetic resonance spectroscopy imaging. Because of the big data and variations in imaging sequences, detection can be affected by multiple factors such as observer variability and visibility and complexity of the lesions. To improve quantitative assessment of the disease, various computer-aided detection systems have been designed to help radiologists in their clinical practice. This review paper presents an overview of literatures on computer-aided detection of prostate cancer with mp-MRI, which include the technology and its applications. The aim of the survey is threefold: an introduction for those new to the field, an overview for those working in the field, and a reference for those searching for literature on a specific application. PMID:27133005

  4. The Clinician's Toolbox: Assessing the Sexual Impacts of Cancer on Adolescents and Young Adults with Cancer (AYAC

    Directory of Open Access Journals (Sweden)

    Sylvie Aubin, PhD

    2015-09-01

    Conclusion: Cancer can have a significant impact on numerous domains of AYAC sexuality. The assessment of and attention to the impact of sexuality on AYAC is crucial in order to provide effective and comprehensive quality patient cancer care. Aubin S and Perez S. The clinician's toolbox: assessing the sexual impacts of cancer on adolescents and young adults with cancer (AYAC. Sex Med 2015;3:198–212.

  5. Moving Forward in Human Cancer Risk Assessment

    OpenAIRE

    Paules, Richard S.; Aubrecht, Jiri; Corvi, Raffaella; Garthoff, Bernward; Kleinjans, Jos C.

    2010-01-01

    Background The current safety paradigm for assessing carcinogenic properties of drugs, cosmetics, industrial chemicals, and environmental exposures relies mainly on in vitro genotoxicity testing followed by 2-year rodent bioassays. This testing battery is extremely sensitive but has low specificity. Furthermore, rodent bioassays are associated with high costs, high animal burden, and limited predictive value for human risks. Objectives We provide a response to a growing appeal for a paradigm ...

  6. Assessment of battery technologies for EV (Electric Vehicle) applications

    Science.gov (United States)

    Ratner, Elliot Z.; Henriksen, Gary L.; Warde, Charles J.

    To guide future R and D program planning, the U.S. Department of Energy (DOE) commissioned an assessment of all viable battery techniques for EV applications. Sixty-seven technology developers in the United States, Canada, Europe, Asia, and Africa were solicited to design a power pack for an Improved Dual-Shaft Electric Propulsions (IDSEP) van. A team of 10 consultants and 8 representatives from DOE's National Laboratories evaluated 43 developer responses and consultant-prepared conceptual designs. Using six criteria---five technical/economic criteria and a maturity/technical barriers criterion---the assessment identified 12 most promising battery technologies.

  7. General support for integrated assessment research. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Dowlatabadi, Hadi

    2001-03-01

    The climate change problem spans an extraordinarily large number of disciplines from earth sciences to social and political sciences. The interaction of processes described by these different fields is why climate change is such a complex issue. Keeping track of these interactions and bringing coherence to the assumptions underlying each disciplinary insight on the climate problem is a massive undertaking. Integrated assessment is an interdisciplinary approach designed to provide systematic evaluations of technically complex problems such as the analysis of environmental change challenges facing humanity. Ph.D. theses stemming from this application are summarized. Then some aspects of Integrated Climate Assessment Models are described.

  8. CT for assessment of pancreatic and periampullary cancer

    International Nuclear Information System (INIS)

    Over a period of 2 years, 77 patients, strongly suspected of having pancreatic cancer, had abdominal CT as part of the diagnostic work-up. The CT images were reviewed by 2 radiologists who did not know the clinical course, the surgical procedure, or the final diagnosis. The positive predictive value of CT for the diagnosis of pancreatic cancer was 92% (82-97%) and the negative predictive value 69% (41-89%). The 95% confidence limits of the positive predictive value of CT in staging the extent of periampullary cancer in 52 patients varied between 21 to 79% and 59 to 100%, with the lowest values in diagnosis of liver metastases. The confidence limits for the negative predictive values in staging varied between 17 to 56% and 67 to 94%, with the highest values concerning liver metastases. We conclude that CT cannot be used as the only diagnostic procedure for confirming or excluding the diagnosis of pancreatic or periampullary cancer, and that the staging of periampullary cancer by CT alone is too inaccurate for the evaluation of resectability. (orig.)

  9. Assessment of breast cancer response to neoadjuvant chemotherapy: Is volumetric MRI a reliable tool?

    Energy Technology Data Exchange (ETDEWEB)

    Lorenzon, Michele [Institute of Radiology, University of Udine, via Colugna 50, 33100 Udine (Italy)], E-mail: michele.lorenzon@gmail.com; Zuiani, Chiara [Institute of Radiology, University of Udine, via Colugna 50, 33100 Udine (Italy)], E-mail: zuiani.chiara@aoud.sanita.fvg.it; Londero, Viviana [Institute of Radiology, University of Udine, via Colugna 50, 33100 Udine (Italy)], E-mail: vlondero@sirm.org; Linda, Anna [Institute of Radiology, University of Udine, via Colugna 50, 33100 Udine (Italy)], E-mail: annalinda33@gmail.com; Furlan, Alessandro [Institute of Radiology, University of Udine, via Colugna 50, 33100 Udine (Italy)], E-mail: ali.furlan@gmail.com; Bazzocchi, Massimo [Institute of Radiology, University of Udine, via Colugna 50, 33100 Udine (Italy)], E-mail: bazzocchi.massimo@aoud.sanita.fvg.it

    2009-07-15

    The purpose of this study was to evaluate the reliability of volumetric magnetic resonance imaging (MRI) in breast cancer size assessment before, during and after neoadjuvant chemotherapy (NAC). Volumetric MRI measures performed on 15 patients with breast cancer were compared with volumes reckoned upon mean lesional diameters, using the same MRI data. Concordance correlation coefficient (CCC), Bland and Altman plots, RECIST evaluation and Cohen's Kappa were assessed, to evaluate the agreement between the two methods. CCC was computed before (0.9357), during (0.8053) and after (0.7499) NAC, in all examinations pooled together (0.8617), and on final tumor volume as a percentage of baseline volume (0.9224). In 2/15 (13.3%) cases RECIST assessment was different. Cohen's Kappa was 0.787 (CI{sub 95%} = 0.513-1.062). In summary, volumetric MRI is a reliable tool to assess breast cancer size before, during and after NAC. Further investigations are needed to understand whether improvements in surgical planning are feasible.

  10. Releasing the full potential of AIKAN - a dry anaerobic digestion biogas technology. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Joernsgaerd, B.; Broegger Kristensen, M.; Wittrup Hansen, M. [Solum Gruppen, Hedehusene (Denmark); Uellendahl, H. [Aalborg Univ. (AAU), Aalborg (Denmark)

    2013-07-15

    This final project report contains a summary of the findings and documentation which have been carried out as a part of the EUDP-supported project ''Documentation and En-ergy Yield Optimisation of AIKAN{sup }- a dry anaerobic digestion biogas technology''. The aim was to improve documentation of the AIKAN{sup }technology, improve performance of the AIKAN{sup }technology and thus remove important barriers for market entry on principal export markets caused by the lack of performance documentation. The final report also contains a description of the subsequent process and technology improvements which have been carried out in order to improve and optimize the production process at the full scale AIKAN{sup }biogas plant, Biovaekst, in Audebo, Denmark. The relevant analyses carried out as part of the different work packages are attached as appendixes to the report. It is the intention that the final report and the attached appendices should function as a work of reference for the employees involved in the day to day running and optimization of the AIKAN{sup }technology. (Author)

  11. Process for Selecting System Level Assessments for Human System Technologies

    Science.gov (United States)

    Watts, James; Park, John

    2006-01-01

    The integration of many life support systems necessary to construct a stable habitat is difficult. The correct identification of the appropriate technologies and corresponding interfaces is an exhaustive process. Once technologies are selected secondary issues such as mechanical and electrical interfaces must be addressed. The required analytical and testing work must be approached in a piecewise fashion to achieve timely results. A repeatable process has been developed to identify and prioritize system level assessments and testing needs. This Assessment Selection Process has been defined to assess cross cutting integration issues on topics at the system or component levels. Assessments are used to identify risks, encourage future actions to mitigate risks, or spur further studies.

  12. Information Technology Integration in Higher Education: A Novel Approach for Impact Assessment

    Directory of Open Access Journals (Sweden)

    Abdulkareem Al-Alwani

    2014-12-01

    Full Text Available In the current technological world of Information services, academic systems are also in the process of adapting information technology solutions. Information systems vary for different applications and specifically in academia domain, a range of information systems are available for different institutions worldwide. Integration of e-learning can optimize implementation of computer-based and computer-assisted educational processes at all levels. Therefore it is imperative to assess and evaluate integration of these information systems because they have serious impact on e-learning processes. In this study an instrument survey is presented for evaluating integration of information technology systems and practices in an educational environment. Survey is constructed using descriptive questions related to information technology tools to assess qualitative impact and usage of such tools. Critical feedback, analysis and suggestions from 25 educationists played a pivotal role in finalizing proposed survey questionnaire. A subsequent test evaluation by teachers and students is also carried out to assess adequate utilization of information systems in Yanbu University College. The results showed that feedback using this survey can help in identifying technological gaps and facilitate effective integration of information technology in an educational environment. Survey instrument proposed in this research can greatly enhance integration of IT tools as it can identify shortcomings by collecting statistical data from feedback of both faculty and students. Solution to these problems is deterministic and can be easily implemented to optimize overall performance of e-learning systems.

  13. Sustainability assessment of tertiary wastewater treatment technologies: a multi-criteria analysis.

    Science.gov (United States)

    Plakas, K V; Georgiadis, A A; Karabelas, A J

    2016-01-01

    The multi-criteria analysis gives the opportunity to researchers, designers and decision-makers to examine decision options in a multi-dimensional fashion. On this basis, four tertiary wastewater treatment (WWT) technologies were assessed regarding their sustainability performance in producing recycled wastewater, considering a 'triple bottom line' approach (i.e. economic, environmental, and social). These are powdered activated carbon adsorption coupled with ultrafiltration membrane separation (PAC-UF), reverse osmosis, ozone/ultraviolet-light oxidation and heterogeneous photo-catalysis coupled with low-pressure membrane separation (photocatalytic membrane reactor, PMR). The participatory method called simple multi-attribute rating technique exploiting ranks was employed for assigning weights to selected sustainability indicators. This sustainability assessment approach resulted in the development of a composite index as a final metric, for each WWT technology evaluated. The PAC-UF technology appears to be the most appropriate technology, attaining the highest composite value regarding the sustainability performance. A scenario analysis confirmed the results of the original scenario in five out of seven cases. In parallel, the PMR was highlighted as the technology with the least variability in its performance. Nevertheless, additional actions and approaches are proposed to strengthen the objectivity of the final results. PMID:27054724

  14. Assessment of a satellite power system and six alternative technologies

    Energy Technology Data Exchange (ETDEWEB)

    Wolsko, T.; Whitfield, R.; Samsa, M.; Habegger, L.S.; Levine, E.; Tanzman, E.

    1981-04-01

    The satellite power system is assessed in comparison to six alternative technologies. The alternatives are: central-station terrestrial photovoltaic systems, conventional coal-fired power plants, coal-gasification/combined-cycle power plants, light water reactor power plants, liquid-metal fast-breeder reactors, and fusion. The comparison is made regarding issues of cost and performance, health and safety, environmental effects, resources, socio-economic factors, and insitutional issues. The criteria for selecting the issues and the alternative technologies are given, and the methodology of the comparison is discussed. Brief descriptions of each of the technologies considered are included. (LEW)

  15. Advanced Turbine Technology Applications Project (ATTAP) and Hybrid Vehicle Turbine Engine Technology Support project (HVTE-TS): Final summary report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-01

    This final technical report was prepared by Rolls-Royce Allison summarizing the multiyear activities of the Advanced Turbine Technology Applications Project (ATTAP) and the Hybrid Vehicle Turbine Engine Technology Support (HVTE-TS) project. The ATTAP program was initiated in October 1987 and continued through 1993 under sponsorship of the US Department of Energy (DOE), Energy Conservation and Renewable Energy, Office of Transportation Technologies, Propulsion Systems, Advanced Propulsion Division. ATTAP was intended to advance the technological readiness of the automotive ceramic gas turbine engine. The target application was the prime power unit coupled to conventional transmissions and powertrains. During the early 1990s, hybrid electric powered automotive propulsion systems became the focus of development and demonstration efforts by the US auto industry and the Department of energy. Thus in 1994, the original ATTAP technology focus was redirected to meet the needs of advanced gas turbine electric generator sets. As a result, the program was restructured to provide the required hybrid vehicle turbine engine technology support and the project renamed HVTE-TS. The overall objective of the combined ATTAP and HVTE-TS projects was to develop and demonstrate structural ceramic components that have the potential for competitive automotive engine life cycle cost and for operating 3,500 hr in an advanced high temperature turbine engine environment. This report describes materials characterization and ceramic component development, ceramic components, hot gasifier rig testing, test-bed engine testing, combustion development, insulation development, and regenerator system development. 130 figs., 12 tabs.

  16. New Modes of Constructive Technology Assessment for Developing Countries

    DEFF Research Database (Denmark)

    Christensen, David; Remmen, Arne

    on ‘technology assessment’ in a search for inspiration. Technology assessment originally featured prominently as a discussion topic two decades ago, but is worth returning to because some principles embedded herein are especially relevant for sustainable co-creation process today targeting developing countries......An old piece of conventional wisdom warns against unsustainable ‘white elephants’ in any attempts at international transferal, adoption or development of technologies in developing countries. After more than half a century of failed attempts to introduce technologies in such settings mostly through...... by a product or process in a developing country. On the other hand are those who design, develop and promote the technological solution. If the latter group is to follow the call for proactively taking in socio-cultural and user knowledge, what methods may be employed? This paper revisits the literature...

  17. Assessing climate change mitigation technology interventions by international institutions

    DEFF Research Database (Denmark)

    de Coninck, Heleen; Puig, Daniel

    2015-01-01

    Accelerating the international use of climate mitigation technologies is key if effortsto curb climate change are to succeed, especially in developing countries, where weakdomestic technological innovation systems constrain the uptake of climate change mitigationtechnologies. Several...... intergovernmental agencies have set up specific programmes to supportthe diffusion of climate mitigation technologies. Using a simplified technological innovationsystem-based framework, this paper aims to systematically review these programmes, with thedual aim of assessing their collective success in promoting...... further developed include knowledge development, legitimation and marketformation. These could be focal areas for the UNFCCC Technology Mechanism. We recommendthat, in future programmes, part of the funding is dedicated to programmes doingresearch and development as well as capability development....

  18. Technology transfer assessment in the nuclear agreement Brazil-Germany

    International Nuclear Information System (INIS)

    The three main arguments utilized in the Nuclear Brazil-Germany Agreement celebrated in 1975 were the following: a) the low Brazilian hydroelectric potential insufficient to attend the increasing of electrical energy demand; b) the low cost of nuclear energy related to hydroelectric energy: c) and finally, the nuclear technology transfer, involving inclusive the fuel cycle and that could permit to Brazil self-sufficiency in the nuclear energy field. Thus, this work intends to describe and discussing the 'technology transfer strategy' trying to understand and showing which are its main characteristics, and also which are the real actuals results. (author)

  19. Technology Innovation Enabling Falls Risk Assessment in a Community Setting

    OpenAIRE

    Ni Scanaill, Cliodhna; Garattini, Chiara; Greene, Barry R; McGrath, Michael J

    2010-01-01

    Approximately one in three people over the age of 65 will fall each year, resulting in significant financial, physical, and emotional cost on the individual, their family, and society. Currently, falls are managed using on-body sensors and alarm pendants to notify others when a falls event occurs. However these technologies do not prevent a fall from occurring. There is now a growing focus on falls risk assessment and preventative interventions. Falls risk is currently assessed in a clinical ...

  20. Sustainability assessment of renewable power and heat generation technologies

    International Nuclear Information System (INIS)

    Rationalisation of consumption, more efficient energy usage and a new energy structure are needed to be achieved in order to shift the structure of energy system towards sustainability. The required energy system is among others characterised by intensive utilisation of renewable energy sources (RES). RES technologies have their own advantages and disadvantages. Nevertheless, for the strategic planning there is a great demand for the comparison of RES technologies. Furthermore, there are additional functions of RES utilisation expected beyond climate change mitigation, e.g. increment of employment, economic growth and rural development. The aim of the study was to reveal the most beneficial RES technologies with special respect to sustainability. Ten technologies of power generation and seven technologies of heat supply were examined in a multi-criteria sustainability assessment frame of seven attributes which were evaluated based on a choice experiment (CE) survey. According to experts the most important characteristics of RES utilisation technologies are land demand and social impacts i.e. increase in employment and local income generation. Concentrated solar power (CSP), hydropower and geothermal power plants are favourable technologies for power generation, while geothermal district heating, pellet-based non-grid heating and solar thermal heating can offer significant advantages in case of heat supply. - highlights: • We used choice experiment to estimate the weights of criteria for the sustainability assessment of RES technologies. • The most important attributes of RES technologies according to experts are land demand and social impacts. • Concentrated solar power (CSP), hydropower and geothermal power plants are advantageous technologies for power generation. • Geothermal district heating, pellet-based non-grid heating and solar thermal heating are favourable in case of heat supply

  1. Asteroid Redirect Mission (ARM) Formulation Assessment and Support Team (FAST) Final Report

    Science.gov (United States)

    Mazanek, Daniel D.; Reeves, David M.; Abell, Paul A.; Asphaug, Erik; Abreu, Neyda M.; Bell, James F.; Bottke, William F.; Britt, Daniel T.; Campins, Humberto; Chodas, Paul W.; Ernst, Carolyn M.; Fries, Marc D.; Gertsch, Leslie S.; Glavin, Daniel P.; Hartzell, Christine M.; Hendrix, Amanda R.; Nuth, Joseph A.; Scheeres, Daniel J.; Sercel, Joel C.; Takir, Driss; Zacny, Kris

    2016-01-01

    The Asteroid Redirect Mission (ARM) Formulation Assessment and Support Team (FAST) was a two-month effort, chartered by NASA, to provide timely inputs for mission requirement formulation in support of the Asteroid Redirect Robotic Mission (ARRM) Requirements Closure Technical Interchange Meeting held December 15-16, 2015, to assist in developing an initial list of potential mission investigations, and to provide input on potential hosted payloads and partnerships. The FAST explored several aspects of potential science benefits and knowledge gain from the ARM. Expertise from the science, engineering, and technology communities was represented in exploring lines of inquiry related to key characteristics of the ARRM reference target asteroid (2008 EV5) for engineering design purposes. Specific areas of interest included target origin, spatial distribution and size of boulders, surface geotechnical properties, boulder physical properties, and considerations for boulder handling, crew safety, and containment. In order to increase knowledge gain potential from the mission, opportunities for partnerships and accompanying payloads were also investigated. Potential investigations could be conducted to reduce mission risks and increase knowledge return in the areas of science, planetary defense, asteroid resources and in-situ resource utilization, and capability and technology demonstrations. This report represents the FASTâ€"TM"s final product for the ARM.

  2. Individual Breast Cancer risk assessment in Underserved Populations: Integrating empirical Bioethics and Health Disparities Research

    OpenAIRE

    Anderson, Emily E.; Hoskins, Kent

    2012-01-01

    Research suggests that individual breast cancer risk assessment may improve adherence to recommended screening and prevention guidelines, thereby decreasing morbidity and mortality. Further research on the use of risk assessment models in underserved minority populations is critical to informing national public health efforts to eliminate breast cancer disparities. However, implementing individual breast cancer risk assessment in underserved patient populations raises particular ethical issue...

  3. Using Technology to Improve Cancer Care: Social Media, Wearables, and Electronic Health Records.

    Science.gov (United States)

    Fisch, Michael J; Chung, Arlene E; Accordino, Melissa K

    2016-01-01

    Digital engagement has become pervasive in the delivery of cancer care. Internet- and cellular phone-based tools and systems are allowing large groups of people to engage with each other and share information. Health systems and individual health professionals are adapting to this revolution in consumer and patient behavior by developing ways to incorporate the benefits of technology for the purpose of improving the quality of medical care. One example is the use of social media platforms by oncologists to foster interaction with each other and to participate with the lay public in dialogue about science, medicine, and cancer care. In addition, consumer devices and sensors (wearables) have provided a new, growing dimension of digital engagement and another layer of patient-generated health data to foster better care and research. Finally, electronic health records have become the new standard for oncology care delivery, bringing new opportunities to measure quality in real time and follow practice patterns, as well as new challenges as providers and patients seek ways to integrate this technology along with other forms of digital engagement to produce more satisfaction in the process of care along with measurably better outcomes. PMID:27249700

  4. Orbit transfer rocket engine integrated control and health monitoring system technology readiness assessment

    Science.gov (United States)

    Bickford, R. L.; Collamore, F. N.; Gage, M. L.; Morgan, D. B.; Thomas, E. R.

    1992-01-01

    The objectives of this task were to: (1) estimate the technology readiness of an integrated control and health monitoring (ICHM) system for the Aerojet 7500 lbF Orbit Transfer Vehicle engine preliminary design assuming space based operations; and (2) estimate the remaining cost to advance this technology to a NASA defined 'readiness level 6' by 1996 wherein the technology has been demonstrated with a system validation model in a simulated environment. The work was accomplished through the conduct of four subtasks. In subtask 1 the minimally required functions for the control and monitoring system was specified. The elements required to perform these functions were specified in Subtask 2. In Subtask 3, the technology readiness level of each element was assessed. Finally, in Subtask 4, the development cost and schedule requirements were estimated for bringing each element to 'readiness level 6'.

  5. The NICE ADHD health technology assessment: A review and critique

    Directory of Open Access Journals (Sweden)

    Schlander Michael

    2008-01-01

    Full Text Available Abstract Background Health technology assessments (HTAs by the National Institute for Health and Clinical Excellence (NICE enjoy high levels of international attention. The present analysis addresses NICE's appraisal of methylphenidate, atomoxetine and dexamphetamine for attention-deficit/hyperactivity disorder (ADHD in children and adolescents, published in March 2006. Methods A qualitative study of NICE Technology Appraisal No. 98 was done focusing on the >600-page technology assessment report, which aimed at evaluating ADHD treatment strategies by a clinical effectiveness review and an economic analysis using meta-analytical techniques and a cost-effectiveness model. Results The technology assessment was unable to differentiate between the various drugs in terms of efficacy, and its economic model was ultimately driven by cost differences. While the assessment concluded that the economic model "clearly identified an optimal treatment strategy" with first-line dexamphetamine, the NICE appraisal committee subsequently found it impossible to distinguish between the different strategies on grounds of cost-effectiveness. Analyzing the assessment reveals gaps and inconsistencies concerning data selection (ultimately relying on a small number of short-term studies only, data synthesis (pooling of heterogeneous study designs and clinical endpoints, and economic model structure (identifying double-counting of nonresponders as a likely source of bias, alongside further methodological anomalies. Conclusion Many conclusions of the NICE technology assessment rest on shaky grounds. There remains a need for a new, state-of-the-art systematic review of ADHD treatment strategies including economic evaluation, which ideally should address outcomes beyond children's health-related quality of life, such as long-term sequelae of the disorder and caregiver burden.

  6. Resource assessment of the Imperial Valley. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Biehler, S.; Lee, T.

    1977-01-01

    A resource assessment of the Imperial Valley has been made based on the use of the gravity anomalies as indicators of total excess mass. These data indicate a potential of producing electric power of 7 to 80 thousand megawatts for 30 years. Over half of the total potential is located in the Salton Sea Anomaly and approximately half of the potential of the Salton Sea field is water covered. An attempt has been made to assess not only the heat in storage in the fluid but also recoverable from the country rock by reinjection. Based on calculations, the natural recharge rate of heat in the Valley due to sea floor spreading is too small to give the resource an indefinite life-span since the economic rates of withdrawal appear to be at least an order of magnitude greater.

  7. Power plant system assessment. Final report. SP-100 Program

    International Nuclear Information System (INIS)

    The purpose of this assessment was to provide system-level insights into 100-kWe-class space reactor electric systems. Using these insights, Rockwell was to select and perform conceptual design studies on a ''most attractive'' system that met the preliminary design goals and requirements of the SP-100 Program. About 4 of the 6 months were used in the selection process. The remaining 2 months were used for the system conceptual design studies. Rockwell completed these studies at the end of FY 1983. This report summarizes the results of the power plant system assessment and describes our choice for the most attractive system - the Rockwell SR-100G System (Space Reactor, 100 kWe, Growth) - a lithium-cooled UN-fueled fast reactor/Brayton turboelectric converter system

  8. Industrial assessment of nonbackfittable PWR design modifications. Final report

    International Nuclear Information System (INIS)

    As part of the US Department of Energy's Advanced Reactor Design Study, various nonbackfittable PWR design modifications were evaluated to determine their potential for improved uranium utilization and commercial viability. Combustion Engineering, Inc. contributed to this effort through participation in the Battelle Pacific Northwest Laboratory industrial assessment of such design modifications. Seven modifications, including the use of higher primary system temperatures and pressures, rapid-frequent refueling, end-of-cycle stretchout, core periphery modifications, radial blankets, low power density cores, and small PWR assemblies, were evaluated with respect to uranium utilization, economics, technical and operational complexity, and several other subjective considerations. Rapid-frequent refueling was judged to have the highest potential although it would probably not be economical for the majority of reactors with the design assumptions used in this assessment

  9. Influence choreographic readiness to gymnasts final assessment of performance skills

    Directory of Open Access Journals (Sweden)

    Omelichyk-Ziurkalova O.A.

    2014-06-01

    Full Text Available Purpose : to provide a quantitative assessment and expert choreographic preparedness gymnasts. Material : the study involved eight gymnasts competition finalists in the floor exercise - female members of the Ukrainian national team in gymnastics. Results : the quantitative indicators of acrobatic and dance elements to determine the baseline assessment. Defined methods complications composition on the floor exercise by reducing the number of acrobatic lines and diagonals and increase the number of gymnastic elements. The theoretical performance of the composite sequence is improved structure and increases the difficulty of the exercise. Conclusions : in the process of composition complications need to pay more attention to the technique of performing gymnastic elements. In improving exercise choreography element replace (in some cases acrobatic element. Based on the results is planned future direction of research in order to improve the training process in gymnastics.

  10. Final Technical Report for University of Michigan Industrial Assessment Center

    Energy Technology Data Exchange (ETDEWEB)

    Atreya, Arvind

    2007-04-17

    The UM Industrial Assessment Center assisted 119 primary metals, automotive parts, metal casting, chemicals, forest products, agricultural, and glass manufacturers in Michigan, Ohio and Indiana to become more productive and profitable by identifying and recommending specific measures to improve energy efficiency, reduce waste and increase productivity. This directly benefits the environment by saving a total of 309,194 MMBtu of energy resulting in reduction of 0.004 metric tons of carbon emissions. The $4,618,740 implemented cost savings generated also saves jobs that are evaporating from the manufacturing industries in the US. Most importantly, the UM Industrial Assessment Center provided extremely valuable energy education to forty one UM graduate and undergraduate students. The practical experience complements their classroom education. This also has a large multiplier effect because the students take the knowledge and training with them.

  11. Lake Mead Complex Final Gather Plan: Environmental Assessment

    OpenAIRE

    U.S. Department of the Interior, Bureau of Land Management, Grand Junction Field Office, Grand Junction, Colorado

    2007-01-01

    This Environmental Assessment (EA) has been prepared by the Bureau of Land Management (BLM) Las Vegas Field Office (LVFO) to analyze the environmental effects of a gather to remove approximately 195 resident wild burros from National Park Service-administered lands adjacent to the El Dorado Mountains, Gold Butte and Muddy Mountains Herd Management Areas (HMAs) within the Lake Mead Complex (LMC) in March 2007. The LMC is located in southern Nevada in Clark County. The BLM Las Vegas Field Offic...

  12. Prioritising investments in health technology assessment: can we assess the potential value for money?

    OpenAIRE

    Linda Davies; Mike Drummond; Panos Papanikoloau

    1999-01-01

    The objective was to develop an economic prioritisation model to assist those involved in (i) the selection and prioritisation of health technology assessment topics and (ii) commissioning of HTA projects. The model used decision analytic techniques to estimate the expected costs and benefits of the health care interventions which were the focus of the HTA question(s) considered by the NHS Health Technology Assessment Programme in England. Initial estimation of the value for money of HTA was ...

  13. Grays River Watershed and Biological Assessment, 2006 Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    May, Christopher; Geist, David [Pacific Northwest National Laboratory

    2007-04-01

    The Grays River Watershed and Biological Assessment was funded to address degradation and loss of spawning habitat for chum salmon (Onchorhynchus keta) and fall Chinook salmon (Onchoryhnchus tshawytscha). In 1999, the National Marine Fisheries Service listed lower Columbia River chum salmon as a threatened Evolutionarily Significant Unit (ESU) under the Endangered Species Act of 1973 (ESA). The Grays River watershed is one of two remaining significant chum salmon spawning locations in this ESU. Runs of Grays River chum and Chinook salmon have declined significantly during the past century, largely because of damage to spawning habitat associated with timber harvest and agriculture in the watershed. In addition, approximately 20-25% of the then-remaining chum salmon spawning habitat was lost during a 1999 channel avulsion that destroyed an important artificial spawning channel operated by the Washington Department of Fish and Wildlife (WDFW). Although the lack of stable, high-quality spawning habitat is considered the primary physical limitation on Grays River chum salmon production today, few data are available to guide watershed management and channel restoration activities. The objectives of the Grays River Watershed and Biological Assessment project were to (1) perform a comprehensive watershed and biological analysis, including hydrologic, geomorphic, and ecological assessments; (2) develop a prioritized list of actions that protect and restore critical chum and Chinook salmon spawning habitat in the Grays River based on comprehensive geomorphic, hydrologic, and stream channel assessments; and (3) gain a better understanding of chum and Chinook salmon habitat requirements and survival within the lower Columbia River and the Grays River. The watershed-based approach to river ecosystem restoration relies on a conceptual framework that describes general relationships between natural landscape characteristics, watershed-scale habitat-forming processes, aquatic

  14. Grays River Watershed and Biological Assessment Final Report 2006.

    Energy Technology Data Exchange (ETDEWEB)

    May, Christopher W.; McGrath, Kathleen E.; Geist, David R. [Pacific Northwest National Laboratory; Abbe, Timothy; Barton, Chase [Herrera Environmental Consultants, Inc.

    2008-02-04

    The Grays River Watershed and Biological Assessment was funded to address degradation and loss of spawning habitat for chum salmon (Onchorhynchus keta) and fall Chinook salmon (Onchoryhnchus tshawytscha). In 1999, the National Marine Fisheries Service listed lower Columbia River chum salmon as a threatened Evolutionarily Significant Unit (ESU) under the Endangered Species Act of 1973 (ESA). The Grays River watershed is one of two remaining significant chum salmon spawning locations in this ESU. Runs of Grays River chum and Chinook salmon have declined significantly during the past century, largely because of damage to spawning habitat associated with timber harvest and agriculture in the watershed. In addition, approximately 20-25% of the then-remaining chum salmon spawning habitat was lost during a 1999 channel avulsion that destroyed an important artificial spawning channel operated by the Washington Department of Fish and Wildlife (WDFW). Although the lack of stable, high-quality spawning habitat is considered the primary physical limitation on Grays River chum salmon production today, few data are available to guide watershed management and channel restoration activities. The objectives of the Grays River Watershed and Biological Assessment project were to (1) perform a comprehensive watershed and biological analysis, including hydrologic, geomorphic, and ecological assessments; (2) develop a prioritized list of actions that protect and restore critical chum and Chinook salmon spawning habitat in the Grays River based on comprehensive geomorphic, hydrologic, and stream channel assessments; and (3) gain a better understanding of chum and Chinook salmon habitat requirements and survival within the lower Columbia River and the Grays River. The watershed-based approach to river ecosystem restoration relies on a conceptual framework that describes general relationships between natural landscape characteristics, watershed-scale habitat-forming processes, aquatic

  15. Self-assessment in cancer patients referred to palliative care

    DEFF Research Database (Denmark)

    Strömgren, Annette S; Goldschmidt, Dorthe; Groenvold, Mogens;

    2002-01-01

    -based study using the European Organization for Research and Treatment of Cancer quality-of-life instrument EORTC QLQ-C30, the Edmonton Symptom Assessment System (ESAS), and the Hospital Anxiety and Depression Scale (HADS) in cancer patients who were receiving palliative care. This report describes the......-based study of symptomatology in consecutive cancer patients in palliative care, achieving rather complete data from the participants. The symptomatology in these patients was very pronounced. The questionnaires were able to detect clinically important differences between places of service.......BACKGROUND: Research in palliative care is considered difficult due to the poor health of patients. However, patient-provided data are essential for a thorough description of patient symptomatology and for the evaluation of care. METHODS: The authors examined the feasibility of a questionnaire...

  16. Tissue proteomics in pancreatic cancer study: discovery, emerging technologies and challenges

    OpenAIRE

    Pan, Sheng; Brentnall, Teresa A.; Kelly, Kimberly; Chen, Ru

    2013-01-01

    Pancreatic cancer is a highly lethal disease that is difficult to diagnose and treat. The advances of proteomics technology, especially quantitative proteomics, have stimulated a great interest to apply this technology for pancreatic cancer study. A variety of tissue proteomics approaches have been applied to investigate pancreatic cancer and the associated diseases. These studies were carried out with various goals, aiming to better understand the molecular mechanisms underlying pancreatic t...

  17. Incorporating the Technology Roadmap Uncertainties into the Project Risk Assessment

    International Nuclear Information System (INIS)

    This paper describes two methods, Technology Roadmapping and Project Risk Assessment, which were used to identify and manage the technical risks relating to the treatment of sodium bearing waste at the Idaho National Engineering and Environmental Laboratory. The waste treatment technology under consideration was Direct Vitrification. The primary objective of the Technology Roadmap is to identify technical data uncertainties for the technologies involved and to prioritize the testing or development studies to fill the data gaps. Similarly, project management's objective for a multi-million dollar construction project includes managing all the key risks in accordance to DOE O 413.3 - ''Program and Project Management for the Acquisition of Capital Assets.'' In the early stages, the Project Risk Assessment is based upon a qualitative analysis for each risk's probability and consequence. In order to clearly prioritize the work to resolve the technical issues identified in the Technology Roadmap, the issues must be cross- referenced to the project's Risk Assessment. This will enable the project to get the best value for the cost to mitigate the risks

  18. Assessment of x-ray technology for narcotics detection

    Science.gov (United States)

    Khan, Siraj M.; Smith, Douglas E.; Hoglund, David E.

    1994-10-01

    This paper describes the plan for the assessment of the second generation X-ray inspection systems based on direct transmission, dual view, dual energy and backscatter technology. The purpose of this assessment is to determine the performance of each of these systems based on the analysis of the data on the detection of cocaine and heroin. The results of this assessment will be of immense value to law enforcement agencies in helping them select the type of X-ray inspection system best suited for their particular application.

  19. Information Technologies in the Assessment of Violations of Cognitive Functions

    Directory of Open Access Journals (Sweden)

    Vitaly P. Omelchenko

    2013-01-01

    Full Text Available This article is about application of information technologies for an assessment of violations of cognitive functions at patients with diabetic and discirculatorencephalopathies. Results of the mathematical analysis of bioelectric activity of a brain of examinees are considered, the most significant factors reflecting existence of cognitive violations are revealed

  20. Assessment, Technology and Democratic Education in the Age of Data

    Science.gov (United States)

    Perrotta, Carlo

    2013-01-01

    This paper contends that powerful techniques to manipulate data, enabled by technological and economic developments, can be easily co-opted to serve the restrictive frameworks of hyper-controlling, managerial accountability that characterise current cultures of summative assessment in education. In response to these challenges, research is…

  1. Reimbursement of pharmaceuticals: Reference pricing versus health technology assessment

    NARCIS (Netherlands)

    M. Drummond (Michael); B. Jönsson (Bengt); F.F.H. Rutten (Frans); T. Stargardt (Tom)

    2011-01-01

    textabstractReference pricing and health technology assessment are policies commonly applied in order to obtain more value for money from pharmaceuticals. This study focussed on decisions about the initial price and reimbursement status of innovative drugs and discussed the consequences for market a

  2. A Qualitative Approach to Assessing Technological Pedagogical Content Knowledge

    Science.gov (United States)

    Groth, Randall; Spickler, Donald; Bergner, Jennifer; Bardzell, Michael

    2009-01-01

    Because technological pedagogical content knowledge is becoming an increasingly important construct in the field of teacher education, there is a need for assessment mechanisms that capture teachers' development of this portion of the knowledge base for teaching. The paper describes a proposal drawing on qualitative data produced during lesson…

  3. Technology Applications for Children with ADHD: Assessing the Empirical Support.

    Science.gov (United States)

    Xu, Chunzhen; Reid, Robert; Steckelberg, Allen

    2002-01-01

    This article reviews technology research (n=20) with students with attention deficit hyperactivity disorder (ADHD) in five categories: computer-assisted instruction, computer-based cognitive training, biofeedback training, assessment, and behavior modification. Analysis of available research suggests there is little well controlled experimental…

  4. Understanding differences in the diffusion of environmentally beneficial technology. Final project report

    Energy Technology Data Exchange (ETDEWEB)

    Blackman, A.; Boyd, J.; Simpson, R.D.; Toman, M.

    1996-12-31

    The factors affecting the diffusion of technical discoveries among firms and nations remain one of the most interesting and important but least understood elements of economic behavior. Recently, interest in technology diffusion has been heightened by a recognition that the spread of technologies could have important implications for environmental quality as well as for market goods and services. A specific motivation for this study was the question of how rapidly technologies that reduce greenhouse gas emissions might diffuse. Technologies in this category include technologies that improve the efficiency of fossil energy use or promote substitution of renewable energy resources. The speed with which these technologies spread could have a significant effect on the rate of accumulation of carbon in the atmosphere. From a modeling perspective, the rate of innovation and diffusion of carbon-reducing technology is known to be a crucial parameter in integrated assessments of climate change risks and policy responses. Thus, a better understanding of factors that might influence the spread of carbon-reducing technologies could be valuable in studies on long-term global change and policy assessment.

  5. Final Environmental Assessment for the Proposed Wallkill River National Wildlife Refuge 1990

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Final Environmental Assessment for the proposed acquisition and establishment of Wallkill River National Wildlife Refuge in Sussex Country, New Jersey. The...

  6. 76 FR 80924 - Boott Hydropower, Inc.; Notice of Availability of Final Environmental Assessment

    Science.gov (United States)

    2011-12-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Boott Hydropower, Inc.; Notice of Availability of Final Environmental Assessment In accordance with the National Environmental Policy Act of 1969 and ] the Federal...

  7. Readings in technology assessment. [in relation to social impact and the law

    Science.gov (United States)

    1975-01-01

    Papers are presented which reflect research in the following areas: development of the concept of technology assessment; institutionalization of technology assessment; the interface between law and technology assessment; and assessment case studies. Case studies include hazards of the medical use of X-rays, environmental noise effects in transportation planning, genetic technology, impact of underground coal mining, and aircraft/airport noise abatement.

  8. CAISI Operational Assessment (OA) data collection results. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-01-31

    One of the lessons learned from Operation Desert Shield/Storm was the inability of deployed Combat Service Support (CSS) computers to exchange data effectively in a battlefield environment. The work-around solution to this previously identified problem has been to physically carry floppy disks between computers. A General Officer Steering Committee, directed by the Vice Chief of Staff of the Army, determined that immediate corrective action was necessary to ensure viability of the CSS Battlefield Mission Area. The study recommended that a three-phased system development plan address short-, mid- and long-term CSS automation communication interface requirements. In response to this study, Program Executive Office (PEO) Standard Army Management Information System (STAMIS) authorized the development of the CSS Automated Information System Interface (CAISI). Phase I (Near-Term) equipped the {open_quotes}first to fight{close_quotes} Contingency Corps units. Phase II (Mid-Term) is being fielded to the remainder of Force Package One units in the active force. Phase III (Long-Term) will equip the remaining units. CAISI is now in the early stages of Phase II fielding. Prior to full Phase II fielding, CAISI must be approved for production by a Milestone III decision authority. Part of the data that will be used in the Milestone III decision is a demonstration of the CAISI`s operational suitability, as assessed by the US Army Operational Test and Evaluation Command (OPTEC). This assessment will be performed through an Operational Assessment (OA) using data provided from previous technical testing, such as the CAISI Customer User Test (CUT), and a field training exercise conducted by units of the XVIII Airborne Corps. The field training exercise data collection took place during two events.

  9. Factors Associated with Men's Assessment of Prostate Cancer Treatment Choice.

    Science.gov (United States)

    Ross, Louie E; Howard, Daniel L; Bowie, Janice V; Thorpe, Roland J; Kinlock, Ballington L; Burt, Carol; LaVeist, Thomas A

    2016-06-01

    The objective of this study is to examine factors among a group of African American and White men in North Carolina and their assessment of prostate cancer treatment choice or belief that treatment chosen was best. A sample of men (N = 877) with a history of prostate cancer diagnosis was recruited from the North Carolina Cancer Registry during 2007-2008 and asked to participate in a telephone interview covering several measures about their initial prostate cancer treatment. Logistic regression was used to assess demographic, psychosocial, and clinical factors on whether they felt that they had chosen the best treatment for the disease. Respondents were majority White (52.7 %), married (75.9 %), and had surgery (67.9 %) as their initial treatment. At the bivariate level, factors associated with the belief that the treatment chosen was best were as follows: White race/ethnicity, higher levels of education, a more recent treatment date, having health insurance coverage, type of treatment received, higher levels of bother from side effects, greater contentment with their quality of life, and doctor discussions of the various treatment options. Similarly, the multivariate analysis showed increased odds of belief that the treatment chosen was the best among demographic (i.e., race/ethnicity, level of education, and health insurance coverage) as well as psychosocial and clinical variables (i.e., greater bother from side effects, greater contentment with their quality of life, and initial treatment received). Results suggest that demographic, psychosocial, and clinical factors play an important role for men in assessing their treatment choices for prostate cancer. PMID:25893926

  10. Fossil energy biotechnology: A research needs assessment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1993-11-01

    The Office of Program Analysis of the US Department of Energy commissioned this study to evaluate and prioritize research needs in fossil energy biotechnology. The objectives were to identify research initiatives in biotechnology that offer timely and strategic options for the more efficient and effective uses of the Nation`s fossil resource base, particularly the early identification of new and novel applications of biotechnology for the use or conversion of domestic fossil fuels. Fossil energy biotechnology consists of a number of diverse and distinct technologies, all related by the common denominator -- biocatalysis. The expert panel organized 14 technical subjects into three interrelated biotechnology programs: (1) upgrading the fuel value of fossil fuels; (2) bioconversion of fossil feedstocks and refined products to added value chemicals; and, (3) the development of environmental management strategies to minimize and mitigate the release of toxic and hazardous petrochemical wastes.

  11. 78 FR 62359 - Red River Hydro LLC; Notice of Availability of Final Environmental Assessment

    Science.gov (United States)

    2013-10-21

    ..., 52 FR 47897), the Office of Energy Projects has reviewed Red River Hydro LLC's application for an... Energy Regulatory Commission Red River Hydro LLC; Notice of Availability of Final Environmental... prepared a final environmental assessment (EA). The project would be located on the Red River in...

  12. ADVANTAGES AND APPLICATIONS OF TISSUE MICROARRAY TECHNOLOGY ON CANCER RESEARCH

    Institute of Scientific and Technical Information of China (English)

    张喜平; 苏丹; 程琪辉

    2003-01-01

    S To provide evidences for exploiting tissue microarray (TMA) technology, we reviewed advantages and applications of TMA on tumor research. TMA has many advantages, including (1) section from TMA blocks can be utilized for the simultaneous analysis of up to 1,000 different tumors at DNA, RNA or protein level; (2) TMA is highly representative of their donor tissues; (3) TMA can improve conservation of tissue resources and experimental reagents, improve internal experimental control, and increase sample numbers per experiment, and can be used for large-scale, massively parallel in situ analysis; (4) TMA facilitates rapid translation of molecular discoveries to clinical applications. TMA has been applied to tumor research, such as glioma, breast tumor, lung cancer and so on. The development of novel biochip technologies has opened up new possibilities for the high-throughput molecular profiling of human tumors. Novel molecular markers emerging from high-throughput expression surveys could be analyzed on tumor TMA. It is anticipated that TMA, a new member of biochip, will soon become a widely used tool for all types of tissue-based research. TMA will lead to a significant acceleration of the transition of basic research findings into clinical applications.

  13. Final Environmental assessment for the Uranium Lease Management Program

    International Nuclear Information System (INIS)

    The US Department of Energy (DOE) has prepared a programmatic environmental assessment (EA) of the proposed action to continue leasing withdrawn lands and DOE-owned patented claims for the exploration and production of uranium and vanadium ores. The Domestic Uranium Program regulation, codified at Title 10, Part 760.1, of the US Code of Federal Regulations (CFR), gives DOE the flexibility to continue leasing these lands under the Uranium Lease Management Program (ULMP) if the agency determines that it is in its best interest to do so. A key element in determining what is in DOE's ''best interest'' is the assessment of the environmental impacts that may be attributable to lease tract operations and associated activities. On the basis of the information and analyses presented in the EA for the ULMP, DOE has determined that the proposed action does not constitute a major Federal action significantly affecting the quality of the human environment, as defined in the National Environmental Policy Act (NEPA) of 1969 (42 United States Code 4321 et seq.), as amended.Therefore, preparation of an environmental impact statement is not required for the ULMP,and DOE is issuing this Finding, of No Significant Impact (FONSI)

  14. Final Environmental assessment for the Uranium Lease Management Program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-01

    The US Department of Energy (DOE) has prepared a programmatic environmental assessment (EA) of the proposed action to continue leasing withdrawn lands and DOE-owned patented claims for the exploration and production of uranium and vanadium ores. The Domestic Uranium Program regulation, codified at Title 10, Part 760.1, of the US Code of Federal Regulations (CFR), gives DOE the flexibility to continue leasing these lands under the Uranium Lease Management Program (ULMP) if the agency determines that it is in its best interest to do so. A key element in determining what is in DOE`s ``best interest`` is the assessment of the environmental impacts that may be attributable to lease tract operations and associated activities. On the basis of the information and analyses presented in the EA for the ULMP, DOE has determined that the proposed action does not constitute a major Federal action significantly affecting the quality of the human environment, as defined in the National Environmental Policy Act (NEPA) of 1969 (42 United States Code 4321 et seq.), as amended.Therefore, preparation of an environmental impact statement is not required for the ULMP,and DOE is issuing this Finding, of No Significant Impact (FONSI).

  15. Final Report Low-temperature Resource Assessment Program

    Energy Technology Data Exchange (ETDEWEB)

    Lienau, P.J. [Geo-Heat Center, Oregon Institute of Technology, Klamath Falls, OR (US); Ross, H. [Earth Sciences and Resources Institute, University of Utah

    1996-02-01

    The U.S. Department of Energy - Geothermal Division (DOE/GD) recently sponsored the Low-Temperature Resource Assessment project to update the inventory of the nation's low- and moderate-temperature geothermal resources and to encourage development of these resources. A database of 8,977 thermal wells and springs that are in the temperature range of 20 degrees Celsius to 150 degrees Celsius has been compiled for ten western states, an impressive increase of 82% compared to the previous assessments. The database includes location, descriptive data, physical parameters, water chemistry and references for sources of data. Computer-generated maps are also available for each state. State Teams have identified 48 high-priority areas for near-term comprehensive resource studies and development. Resources with temperatures greater than 50 degrees Celsius located within 8 km of a population center were identified for 271 collocated cities. Geothermal energy costevaluation software has been developed to quickly identify the cost of geothermally supplied heat to these areas in a fashion similar to that used for conventionally fueled heat sources.

  16. Low-temperature resource assessment program. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lienau, P.J. [Oregon Inst. of Tech., Klamath Falls, OR (United States). Geo-Heat Center; Ross, H. [Utah Univ., Salt Lake City, UT (United States). Earth Sciences and Resources Inst.

    1996-02-01

    The US Department of Energy - Geothermal Division (DOE/GD) recently sponsored the Low-Temperature Resource Assessment project to update the inventory of the nation`s low- and moderate-temperature geothermal resources and to encourage development of these resources. A database of 8,977 thermal wells and springs that are in the temperature range of 20{degrees}C to 150{degrees}C has been compiled for ten western states, an impressive increase of 82% compared to the previous assessments. The database includes location, descriptive data, physical parameters, water chemistry and references for sources of data. Computer-generated maps are also available for each state. State Teams have identified 48 high-priority areas for near-term comprehensive resource studies and development. Resources with temperatures greater than 50{degrees}C located within 8 km of a population center were identified for 271 collocated cities. Geothermal energy cost evaluation software has been developed to quickly identify the cost of geothermally supplied heat to these areas in a fashion similar to that used for conventionally fueled heat sources.

  17. Final Technical Report: Renewable Energy Feasibility Study and Resources Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Rivero, Mariah [BEC Environmental, Inc., Las Vegas, NV (United States)

    2016-02-28

    In March 2011, the U.S. Department of Energy (DOE) awarded White Pine County, Nevada, a grant to assess the feasibility of renewable resource-related economic development activities in the area. The grant project included a public outreach and training component and was to include a demonstration project; however, the demonstration project was not completed due to lack of identification of an entity willing to locate a project in White Pine County. White Pine County completed the assessment of renewable resources and a feasibility study on the potential for a renewable energy-focused economic sector within the County. The feasibility study concluded "all resources studied were present and in sufficient quantity and quality to warrant consideration for development" and there were varying degrees of potential economic impact based on the resource type and project size. The feasibility study and its components were to be used as tools to attract potential developers and other business ventures to the local market. White Pine County also marketed the County’s resources to the renewable energy business community in an effort to develop contracts for demonstration projects. The County also worked to develop partnerships with local educational institutions, including the White Pine County School District, conducted outreach and training for the local community.

  18. Biomedical Computing Technology Information Center (BCTIC): Final progress report, March 1, 1986-September 30, 1986

    International Nuclear Information System (INIS)

    During this time, BCTIC packaged and disseminated computing technology and honored all requests made before September 1, 1986. The final month of operation was devoted to completing code requests, returning submitted codes, and sending out notices of BCTIC's termination of services on September 30th. Final BCTIC library listings were distributed to members of the active mailing list. Also included in the library listing are names and addresses of program authors and contributors in order that users may have continued support of their programs. The BCTIC library list is attached

  19. Assessing nano cellulose developments using science and technology indicators

    Energy Technology Data Exchange (ETDEWEB)

    Milanez, Douglas Henrique; Amaral, Roniberto Morato do; Faria, Leandro Innocentini Lopes de; Gregolin, Jose Angelo Rodrigues, E-mail: douglasmilanez@yahoo.com.br [Universidade Federal de Sao Carlos (UFSCar), SP (Brazil). Nucleo de Informacao Tecnologica em Materiais. Dept. de Engenharia de Materiais

    2013-11-01

    This research aims to examine scientific and technological trends of developments in nano cellulose based on scientometric and patent indicators obtained from the Science Citation Index and Derwent Innovations Index in 2001-2010. The overall nano cellulose activity indicators were compared to nanotechnology and other selected nano materials. Scientific and technological future developments in nano cellulose were forecasted using extrapolation growth curves and the main countries were also mapped. The results showed that nano cellulose publications and patent documents have increased rapidly over the last five years with an average growth rate higher than that of nanotechnology and fullerene. The USA, Japan, France, Sweden and Finland all played a significant role in nano cellulose development and the extrapolation growth curves suggested that nano cellulose scientific and technological activities are still emerging. Finally, the evidence from this study recommends monitoring nano cellulose S and T advances in the coming years. (author)

  20. Assessing nano cellulose developments using science and technology indicators

    International Nuclear Information System (INIS)

    This research aims to examine scientific and technological trends of developments in nano cellulose based on scientometric and patent indicators obtained from the Science Citation Index and Derwent Innovations Index in 2001-2010. The overall nano cellulose activity indicators were compared to nanotechnology and other selected nano materials. Scientific and technological future developments in nano cellulose were forecasted using extrapolation growth curves and the main countries were also mapped. The results showed that nano cellulose publications and patent documents have increased rapidly over the last five years with an average growth rate higher than that of nanotechnology and fullerene. The USA, Japan, France, Sweden and Finland all played a significant role in nano cellulose development and the extrapolation growth curves suggested that nano cellulose scientific and technological activities are still emerging. Finally, the evidence from this study recommends monitoring nano cellulose S and T advances in the coming years. (author)

  1. Assessing nanocellulose developments using science and technology indicators

    Directory of Open Access Journals (Sweden)

    Douglas Henrique Milanez

    2013-06-01

    Full Text Available This research aims to examine scientific and technological trends of developments in nanocellulose based on scientometric and patent indicators obtained from the Science Citation Index and Derwent Innovations Index in 2001-2010. The overall nanocellulose activity indicators were compared to nanotechnology and other selected nanomaterials. Scientific and technological future developments in nanocellulose were forecasted using extrapolation growth curves and the main countries were also mapped. The results showed that nanocellulose publications and patent documents have increased rapidly over the last five years with an average growth rate higher than that of nanotechnology and fullerene. The USA, Japan, France, Sweden and Finland all played a significant role in nanocellulose development and the extrapolation growth curves suggested that nanocellulose scientific and technological activities are still emerging. Finally, the evidence from this study recommends monitoring nanocellulose S&T advances in the coming years.

  2. Assessment of structural analysis technology for elastic shell collapse problems

    Science.gov (United States)

    Knight, N. F., Jr.; Macy, S. C.; Mccleary, S. L.

    1989-01-01

    The prediction of the ultimate load carrying capability for compressively loaded shell structures is a challenging nonlinear analysis problem. Selected areas of finite element technology research and nonlinear solution technology are assessed. Herein, a finite element analysis procedure is applied to four shell collapse problems which have been used by computational structural mechanics researchers in the past. This assessment will focus on a number of different shell element formulations and on different approaches used to account for geometric nonlinearities. The results presented confirm that these aspects of nonlinear shell analysis can have a significant effect on the predicted nonlinear structural response. All analyses were performed using the CSM Testbed software system which allowed a convenient assessment of different element formulations with a consistent approach to solving the discretized nonlinear equations.

  3. Human factors assessments of innovative technologies: Robotics sector

    International Nuclear Information System (INIS)

    The U.S. Department of Energy (DOE) has funded major environmental technology developments over the past several years. One area that received significant attention is robotics, which has resulted in the development of a wide range of unique robotic systems tailored to the many tasks unique to the DOE complex. These systems are often used in highly hazardous environments, which reduces or eliminates worker exposures. The DOE, concurrent with the technology development initiative, also established and funded a 5-yr cooperative agreement intended to interface with the technology development community-with specific attention to the occupational safety and health aspects associated with individual technologies through human factors and hazard assessments. This program is now in its third year

  4. Seismic design of nuclear power plants. An assessment. Final report

    International Nuclear Information System (INIS)

    A review and evaluation of the analytical methods, design methods, and design standards used in the seismic design of nuclear power plants are presented. Three major areas were investigated: (a) soils, siting, and seismic ground motion specification; (b) soil-structure interaction; (c) the response of major nuclear power plant structures and components. The purpose of this review and evaluation program was to prepare an independent assessment of the state-of-the-art of the seismic design of nuclear power plants and to identify seismic analysis and design research areas meriting support by the various organizations comprising the 'nuclear power industry'. Criteria used for evaluating the relative importance of alternative research areas included the potential research impact on nuclear power plant siting, design, construction, cost, safety, licensing, and regulation

  5. CleanFleet. Final report: Volume 5, employee attitude assessment

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-01

    The experiences of couriers, operations managers, vehicle handlers (refuelers), and mechanics who drove and/or worked with alternative fuel vehicles, and the attitudes and perceptions of people with these experiences, are examined. Five alternative fuels studied in the CleanFleet project are considers& compressed natural gas, propane gas, California Phase 2 reformulated gasoline, M-85, and electricity. The three major areas of interest include comparative analysis of issues such as health, safety and vehicle performance, business issues encompassing several facets of station operations, and personal commentary and opinions about the CleanFleet project and the alterative fuels. Results of the employee attitude assessment are presented as both statistical and qualitative analysis.

  6. BPA/PGE transmission support project: Final environmental assessment

    International Nuclear Information System (INIS)

    This Mitigation Action Plan describes the mitigation measures identified in the BPA/PGE Transmission Support Project Environmental Assessment. These measures commit to actions that will reduce the environmental impacts that could occur by constructing, operating and maintaining the transmission line and related facilities. They have been developed in coordination with environmental specialists, design and construction engineers and maintenance personnel. The measures will be written into the construction specifications for the project, which is expected to be constructed by contract personnel. Unless noted in the plan, the construction inspector or the line foreman would be responsible for carrying out the mitigation; environmental staff would also monitor the area for mitigation effectiveness. The right-of-way would be cleared in 1997 or 1998, and construction would begin in the spring of 1998 and be completed later that fall

  7. Comment Response on the Final Report: Peer Review of the Total System Performance Assessment-Viability Assessment (TSPA-VA)

    International Nuclear Information System (INIS)

    The Management and Operating Contractor established a Performance Assessment Peer Review Panel (hereinafter ''the Panel'') at the request of the U.S. Department of Energy Yucca Mountain Site Characterization Office. The objectives of the peer review were to provide: (1) A formal, independent evaluation and critique of Viability Assessment of a Repository at Yucca Mountain: Total System Performance Assessment, Volume 3 (DOE 1998a; hereinafter ''Total System Performance Assessment-Viability Assessment'') that was conducted in support of the Viability Assessment of a Repository at Yucca Mountain (DOE 1998b). (2) Suggestions for improvements as the U.S. Department of Energy prepares to develop the documentation for a Total System Performance Assessment to support a potential License Application. The Panel conducted a phased review over a two-year period to observe the development and, ultimately, to review the Total System Performance Assessment-Viability Assessment (DOE 1998a). During the development of the Total System Performance Assessment-Viability Assessment (DOE 1998a), the Panel submitted three Interim Reports (Whipple et al., 1997a, 1997b, and 1998) to the Management and Operating Contractor with recommendations and comments on the process models, model abstractions, and draft documentation for the Total System Performance Assessment-Viability Assessment (DOE 1998a). The Panel's Final Report Total System Performance Assessment Peer Review Panel (Whipple et al. 1999; hereinafter ''Final Report'') on the Total System Performance Assessment-Viability Assessment (DOE 1998a) is based primarily on the completed Total System Performance Assessment-Viability Assessment (DOE 1998a), the Total System Performance Assessment-Viability Assessment (TSPA-VA) Analyses Technical Basis Document (CRWMS M and O 1998), and the cited references. The Final Report (Whipple et al. 1999) includes the major points from the three Interim Reports (Whipple et al. 1997a, 1997b, and 1998

  8. Actinide partitioning-transmutation program final report. I. Overall assessment

    International Nuclear Information System (INIS)

    This report is concerned with an overall assessment of the feasibility of and incentives for partitioning (recovering) long-lived nuclides from fuel reprocessing and fuel refabrication plant radioactive wastes and transmuting them to shorter-lived or stable nuclides by neutron irradiation. The principal class of nuclides considered is the actinides, although a brief analysis is given of the partitioning and transmutation (P-T) of 99Tc and 129I. The results obtained in this program permit us to make a comparison of the impacts of waste management with and without actinide recovery and transmutation. Three major conclusions concerning technical feasibility can be drawn from the assessment: (1) actinide P-T is feasible, subject to the acceptability of fuels containing recycle actinides; (2) technetium P-T is feasible if satisfactory partitioning processes can be developed and satisfactory fuels identified (no studies have been made in this area); and (3) iodine P-T is marginally feasible at best because of the low transmutation rates, the high volatility, and the corrosiveness of iodine and iodine compounds. It was concluded on the basis of a very conservative repository risk analysis that there are no safety or cost incentives for actinide P-T. In fact, if nonradiological risks are included, the short-term risks of P-T exceed the long-term benefits integrated over a period of 1 million years. Incentives for technetium and iodine P-T exist only if extremely conservative long-term risk analyses are used. Further RD and D in support of P-T is not warranted

  9. A model for technology assessment and commercialization for innovative disruptive technologies

    Energy Technology Data Exchange (ETDEWEB)

    KASSICIEH, SULEIMAN K.; WALSH, STEVE; MCWHORTER,PAUL J.; CUMMINGS JR.,JOHN C.; WILLIAMS,W. DAVID; ROMIG JR.,ALTON D.

    2000-05-17

    Disruptive technologies are scientific discoveries that break through the usual product technology capabilities and provide a basis for a new competitive paradigm as described by Anderson and Tushman [1990], Tushman and Rosenkopf [1992], and Bower and Christensen [1995]. Discontinuous innovations are products/processes/services that provide exponential improvements in the value received by the customer much in the same vein as Walsh [1996], Lynn, Morone and Paulson [1996], and Veryzer [1998]. For more on definitions of disruptive technologies and discontinuous innovations, see Walsh and Linton [1999] who provide a number of definitions for disruptive technologies and discontinuous innovations. Disruptive technologies and discontinuous innovations present a unique challenge and opportunity for R and D organizations seeking to build their commercialization efforts and to reinvent the corporation. These technologies do not have a proven path from scientific discovery to mass production and therefore require novel approaches. These critically important technologies are the wellspring of wealth creation and new competency generation but are not readily accepted by the corporate community. They are alternatively embraced and eschewed by the commercial community. They are finally accepted when the technology has already affected the industry or when the technological horse has already flown out of the hanger. Many firms, especially larger firms, seem reluctant to familiarize themselves with these technologies quickly. The trend seems to be that these firms prefer to react to a proven disruptive technology that has changed the product market paradigm. If true, then there is cause for concern. This paper will review the literature on disruptive technologies presenting a model of the progression from scientific idea to mass production for disruptive technologies contrasted to the more copious incremental technologies. The paper will then describe Sandia National Laboratories

  10. Environmental carcinogenic agents and cancer prevention. Risk assessment and management

    International Nuclear Information System (INIS)

    Many agents in our environment have been established as being carcinogenic, and in most cases, the carcinogenic properties of these agents were identified because of high-dose occupational or accidental exposure. Risk characterization, taking into account the dose-response relationship, and exposure assessment are essential for risk assessment and subsequent cancer prevention. Based on scientific risk assessment, risk management should be conducted practically by considering the economic, social, political, and other technical issues and by balancing the risks and benefits. Asbestos and environmental tobacco smoke are typical examples of established carcinogenic agents in the general environment, contributing to low-dose exposure. Further epidemiological studies are required to investigate the carcinogenicity of low-dose exposure to known carcinogenic agents such as arsenic and cadmium through dietary intake, radiation via medical and natural exposure, and air pollution due to diesel exhaust. In contrast, occupational chemical exposure to 1,2-dichloropropane and/or dichloromethane, whose carcinogenicity had not been established, was suggested to cause cholangiocarcinoma among workers involved in offset color proof-printing only after a rare situation of high-dose exposure was unveiled. Continuous monitoring of unusual cancer occurrences in target populations such as workers in occupational and regional settings as well as exposure reduction to suspected carcinogenic agents to levels as low as reasonably achievable is essential for reducing the risk of cancer due to environmental carcinogens. (author)

  11. Organ Dose Assessment and Evaluation of Cancer Risk on Mars Surface

    Science.gov (United States)

    Kim, Myung-Hee; Cucinotta, Francis A.

    2011-01-01

    Organ specific fluence spectra and doses for large solar particle events (SPE) and galactic cosmic rays (GCR) at various levels of solar activity are simulated on the surface of Mars using the HZETRN/QMSFRG computer code and the 2010 version of the Badhwar and O Neill GCR model. The NASA JSC propensity model of SPE fluence and occurrence is used to consider upper bounds on SPE fluence for increasing mission lengths. To account for the radiation transmission through the Mars atmosphere, a vertical distribution of Mars atmospheric thickness is calculated from the temperature and pressure data of Mars Global Surveyor. To describe the spherically distributed atmospheric distance on the Mars surface at each elevation, the directional cosine distribution is implemented. The resultant directional shielding by Mars atmosphere at each elevation is then coupled with vehicle and body shielding for organ dose estimates. Finally, cancer risks for astronauts exploring Mars can be assessed by applying the NASA Space Radiation Cancer Risk 2010 model with the resultant organ dose estimates. Variations of organ doses and cancer risk quantities on the surface of Mars, which are due to a 16-km elevation range between the Tharsis Montes and the Hellas impact basin, are visualized on the global topography of Mars measured by the Mars Orbiter Laser Altimeter. It is found that cancer incidence risks are about 2-fold higher than mortality risks with a disproportionate increase in skin and thyroid cancers for male and female astronauts and in breast cancer for female astronauts. The number of safe days, defined by the upper 95% percent confidence level to be below cancer limits, on Mars is analyzed for several Mars mission design scenarios.

  12. The Contribution of Health Technology Assessment, Health Needs Assessment, and Health Impact Assessment to the Assessment and Translation of Technologies in the Field of Public Health Genomics

    DEFF Research Database (Denmark)

    Rosenkotter, N.; Vondeling, H.; Blancquaert, I.;

    2011-01-01

    contribute to the systematic translation and assessment of genomic health applications by focussing at population level and on public health policy making. It is shown to what extent HTA, HNA and HIA contribute to translational research by using the continuum of translational research (T1-T4) in genomic...... identify infrastructural needs. HIA delivers information on the impact of technologies in a wider scope and promotes informed decision making. HTA, HNA and HIA provide a partly overlapping and partly unique set of methodologies and infrastructure for the translation and assessment of genomic health......The European Union has named genomics as one of the promising research fields for the development of new health technologies. Major concerns with regard to these fields are, on the one hand, the rather slow and limited translation of new knowledge and, on the other hand, missing insights into the...

  13. Transferability of health technology assessments and economic evaluations: a systematic review of approaches for assessment and application

    Directory of Open Access Journals (Sweden)

    Goeree R

    2011-06-01

    , while others proposed an assessment of critical criteria first, followed by an assessment of other noncritical factors. Finally some authors proposed a quantitative score or index to measure transferability potential.Conclusion: Despite a number of publications on the topic, the proposed approaches and the factors used for assessing geographic transferability potential have varied substantially across the papers reviewed. Most promising is the identification of an extensive checklist of critical and noncritical factors in determining transferability potential, which may form the basis for consensus of a future tool. Due to the complexities of identifying appropriate weights for each of the noncritical factors, it is still uncertain whether the assessment and calculation of an overall transferability score or index will be practical or useful for transferability considerations in the future.Keywords: costs and cost analysis, economic evaluation, health technology assessment, geographic transferability, portability, generalizability

  14. Economical-environmental assessment on technologies producing electric energy

    International Nuclear Information System (INIS)

    Currently, the electric power industry is undergoing substantial regulatory and organizational change with respect to economical and environmental aspects. Under these circumstances, with utilization of analytic hierarchy process (AHP) concept, we consider the assessment of Technologies producing energy from financial and pollution viewpoint. AHP techniques is one of the efficient methods in analysis of complex and multi-criteria problems, which has plenty of applications. General pattern of this assessment has been introduced, and the main goal is determining of overall priority weights for each technology. With using this pattern, overall priority weights has been determined for thermal, combined cycle and Gas turbine plants. It has been cleared that relative priority of these plants will change, if relative priority of assessment criterions changes. For application of this approach, capital budgeting process and selection of some suitable technologies among the alternatives candidate for construction have been presented. In this process the objective is to maximize the sum of overall priority weights of technologies which have been identified from AHP. Constraints are about the construction budget and annual budget for emission allowances. This process is in the integer programming IP form an has been applied to three kind of power plants with reasonable assumptions

  15. Technology Innovation Enabling Falls Risk Assessment in a Community Setting.

    Science.gov (United States)

    Ni Scanaill, Cliodhna; Garattini, Chiara; Greene, Barry R; McGrath, Michael J

    2011-06-01

    Approximately one in three people over the age of 65 will fall each year, resulting in significant financial, physical, and emotional cost on the individual, their family, and society. Currently, falls are managed using on-body sensors and alarm pendants to notify others when a falls event occurs. However these technologies do not prevent a fall from occurring. There is now a growing focus on falls risk assessment and preventative interventions. Falls risk is currently assessed in a clinical setting by expert physiotherapists, geriatricians, or occupational therapists following the occurrence of an injurious fall. As the population ages, this reactive model of care will become increasingly unsatisfactory, and a proactive community-based prevention strategy will be required. Recent advances in technology can support this new model of care by enabling community-based practitioners to perform tests that previously required expensive technology or expert interpretation. Gait and balance impairment is one of the most common risk factors for falls. This paper reviews the current technical and non-technical gait and balance assessments, discusses how low-cost technology can be applied to objectively administer and interpret these tests in the community, and reports on recent research where body-worn sensors have been utilized. It also discusses the barriers to adoption in the community and proposes ethnographic research as a method to investigate solutions to these barriers. PMID:21660088

  16. Bench-scale co-processing economic assessment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Gala, H.B.; Marker, T.L.; Miller, E.N.

    1994-11-01

    The UOP Co-Processing scheme is a single-stage slurry catalyzed process in which petroleum vacuum resid and coal are simultaneously upgraded to a high-quality synthetic oil. A highly active dispersed catalyst has been developed which enables the operation of the co-processing unit at relatively moderate and high temperatures and relatively high pressure. Under the current contract, a multi-year research program was undertaken to study the technical and economic feasibility of this technology. All the contractual tasks were completed. Autoclave experiments were carried out to evaluate dispersed vanadium catalysts, molybdenum catalysts, and a less costly UOP-proprietary catalyst preparation technique. Autoclave experiments were also carried out in support of the continuous pilot plant unit operation and to study the effects of the process variables (pressure, temperature, and metal loading on the catalyst). A total of 24 continuous pilot plant runs were made. Research and development efforts during the pilot plant operations were concentrated on addressing the cost effectiveness of the UOP single-stage slurry catalyzed co-processing concept based on UOP experience gained in the previous DOE contract. To this end, effect of catalyst metal concentration was studied and a highly-active Mo-based catalyst was developed. This catalyst enabled successful long-term operation (924 hours) of the continuous bench-scale plant at highly severe operating conditions of 3,000 psig, 465{degree}C temperature, and 2:1 resid-to-MAF (moisture- and ash-free) coal ratio with 0.1 wt % active metal. The metal loading of the catalyst was low enough to consider the catalyst as a disposable slurry catalyst. Also, liquid recycle was incorporated in the pilot plant design to increase the, reactor back mixing and to increase the flow of liquid through the reactor (to introduce turbulence in the reactor) and to represent the design of a commercial-scale reactor.

  17. DOE SciDAC's Earth System Grid Center for Enabling Technologies Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Dean N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2011-09-27

    Computing Centre, the National Aeronautics and Space Administration Jet Propulsion Laboratory, and the National Oceanic and Atmospheric Administration. The ESGF software is distinguished from other collaborative knowledge systems in the climate community by its widespread adoption, federation capabilities, and broad developer base. It is the leading source for present climate data holdings, including the most important and largest data sets in the global-climate community, and - assuming its development continues - we expect it to be the leading source for future climate data holdings as well. Recently, ESG-CET extended its services beyond data-file access and delivery to include more detailed information products (scientific graphics, animations, etc.), secure binary data-access services (based upon the OPeNDAP protocol), and server-side analysis. The latter capabilities allow users to request data subsets transformed through commonly used analysis and intercomparison procedures. As we transition from development activities to production and operations, the ESG-CET team is tasked with making data available to all users seeking to understand, process, extract value from, visualize, and/or communicate it to others. This ongoing effort, though daunting in scope and complexity, will greatly magnify the value of numerical climate model outputs and climate observations for future national and international climate-assessment reports. The ESG-CET team also faces substantial technical challenges due to the rapidly increasing scale of climate simulation and observational data, which will grow, for example, from less than 50 terabytes for the last Intergovernmental Panel on Climate Change (IPCC) assessment to multiple Petabytes for the next IPCC assessment. In a world of exponential technological change and rapidly growing sophistication in climate data analysis, an infrastructure such as ESGF must constantly evolve if it is to remain relevant and useful. Regretfully, we submit our

  18. Willow Creek Wildlife Mitigation Project. Final Environmental Assessment.

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    Today`s notice announces BPA`s proposal to fund land acquisition or acquisition of a conservation easement and a wildlife management plan to protect and enhance wildlife habitat at the Willow Creek Natural Area in Eugene, Oregon. This action would provide partial mitigation for wildlife and wildlife habitat lost by the development of Federal hydroelectric projects in the Willamette River Basin. The project is consistent with BPA`s obligations under provisions of the Pacific Northwest Electric Power Planning and Conservation Act of 1980 as outlined by the Northwest Power Planning Council`s 1994 Columbia River Basin Fish and Wildlife Program. BPA has prepared an environmental assessment (DOE/EA-1023) evaluating the proposed project. Based on the analysis in the EA, BPA has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an environmental impact statement (EIS) is not required and BPA is issuing this FONSI.

  19. Hellsgate Winter Range: Wildlife Mitigation Project. Final Environmental Assessment

    International Nuclear Information System (INIS)

    BPA proposes to fund the Hellsgate Winter Range: Wildlife Mitigation Project (Project) in a cooperative effort with the Colville Confederated Tribes and the Bureau of Indian Affairs (BIA). The Project is intended to mitigate for wildlife and wildlife habitat adversely affected by the construction of Grand Coulee and Chief Joseph Dams and their reservoirs. The Project would allow the sponsors to secure land and conduct wildlife habitat improvement and long-term management activities within the boundaries of the Colville Indian Reservation. BPA has prepared an Environmental Assessment (EA) (DOE/EA-0940) evaluating the potential environmental effects of the proposed Project (Alternative B) and No Action (Alternative A). Protection and re-establishment of riparian and upland habitat on the Colville Indian Reservation, under Alternative B, would not have a significant adverse environmental impact because: (1) there would be only limited, mostly short-term adverse impacts on soils, water quality, air quality, vegetation, and wildlife (including no effect on endangered species); and (2) there would be no adverse effect on water quantity, cultural resources, or land use. Based on the analysis in the EA, BPA has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an Environmental Impact Statement (EIS) is not required and BPA is issuing this FONSI

  20. Willow Creek Wildlife Mitigation Project. Final environmental assessment

    International Nuclear Information System (INIS)

    Today's notice announces BPA's proposal to fund land acquisition or acquisition of a conservation easement and a wildlife management plan to protect and enhance wildlife habitat at the Willow Creek Natural Area in Eugene, Oregon. This action would provide partial mitigation for wildlife and wildlife habitat lost by the development of Federal hydroelectric projects in the Willamette River Basin. The project is consistent with BPA's obligations under provisions of the Pacific Northwest Electric Power Planning and Conservation Act of 1980 as outlined by the Northwest Power Planning Council's 1994 Columbia River Basin Fish and Wildlife Program. BPA has prepared an environmental assessment (DOE/EA-1023) evaluating the proposed project. Based on the analysis in the EA, BPA has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an environmental impact statement (EIS) is not required and BPA is issuing this FONSI

  1. Assessment of inspectability of LMFBR designs. Final report

    International Nuclear Information System (INIS)

    This two-volume report provides a comprehensive review of the inspectability of specific portions of loop- and pool-type LMFBR (1000-MWe) designs selected by EPRI. The designs were developed during the mid to late 1970s by three independent design teams (General Electric Co., Rockwell International, and Westinghouse) under the sponsorship of DOE (formerly ERDA) and EPRI. The requirements for normal, contingency, and post-repair inspections, addressed in this report, were established from Draft 12 of the ASME Boiler and Pressure Vessel Code, Section XI Division 3, issued in September 1979. These requirements, the intrinsic characteristics of the designs, the environmental (radiation, thermal, and atmospheric) aspects, and the available (present and near-term) inspection techniques, formed the basis for assessing the selected portions of the design or (1) accessibility, (2) feasibility, (3) practicality, and (4) costs to perform the above-specified inspections. Changes and additions fly ash has been as a concrete additive; however, extensive pilot scale development is underway to advance ash use in the TVA region in such areas as mineral and magnetite recovery, and mineral wool insulation. Recommended studies include: (1) the feasibility of converting existing wet fly d by the fuels include: residential (which includes residential and commercial), elthodology will be developed and verified in Phase II

  2. Final Safety Assessment of Coal Tar as Used in Cosmetics

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    Coal Tar is a semisolid by-product obtained in the destructive distillation of bituminous coal, which functions in cosmetic products as a cosmetic biocide and denaturant-antidandruff agent is also listed as a function, but this is considered an over-the-counter (OTC) drug use. In 2002, Coal Tar was reported to the Food and Drug Administration (FDA) to be used in four formulations, all of which appear to be OTC drug products. Coal Tar is monographed by the FDA as Category I (safe and effective) OTC drug ingredient for use in the treatment of dandruff, seborrhoea, and psoriasis. Coal Tar is absorbed through the skin of animals and humans and is systemically distributed. Although the Cosmetic Ingredient Review (CIR) Expert Panel believes that Coal Tar use as an antidandruff ingredient in OTC drug preparations is adequately addressed by the FDA regulations, the Panel also believes that the appropriate concentration of use of Coal Tar in cosmetic formulations should be that level that does not have a biological effect in the user. Additional data needed to make a safety assessment include product types in which Coal Tar is used (other than as an OTC drug ingredient), use concentrations, and the maximum concentration that does not induce a biological effect in users.

  3. Final report of the group research. Advanced Technology for Medical Imaging Research. 1996-2000 FY

    International Nuclear Information System (INIS)

    This report involves the organization of the research groups (4 units of radiopharmaceutical chemistry, radiotracer and radiopharmacology, clinical imaging, and molecular informative research), 5 research reports and 38 published research papers. The research reports concern Fundamental researches on the availability and production of PET radiopharmaceuticals using the National Institute of Radiological Sciences (NIRS) cyclotron, Design and evaluation of in vivo radiopharmaceuticals for PET measurement (kinetics and metabolism in small animals and primates), Fundamental studies on development of technique radiation measurement, Clinical application of medical imaging technology in the fields of neuroscience, cardiovascular, cancer diagnosis and others, and A study to establish and evaluate a lung cancer screening system using spiral CT units which is in pilot-progress in Kanto and Kansai regions. (N.I.)

  4. Social and ethical analysis in health technology assessment.

    Science.gov (United States)

    Tantivess, Sripen

    2014-05-01

    This paper presents a review of the domestic and international literature on the assessment of the social and ethical implications of health technologies. It gives an overview of the key concepts, principles, and approaches that should be taken into account when conducting a social and ethical analysis within health technology assessment (HTA). Although there is growing consensus among healthcare experts that the social and ethical ramifications of a given technology should be examined before its adoption, the demand for this kind of analysis among policy-makers around the world, including in Thailand, has so far been lacking. Currently decision-makers mainly base technology adoption decisions using evidence on clinical effectiveness, value for money, and budget impact, while social and ethical aspects have been neglected. Despite the recognized importance of considering equity, justice, and social issues when making decisions regarding health resource allocation, the absence of internationally-accepted principles and methodologies, among other factors, hinders research in these areas. Given that developing internationally agreed standards takes time, it has been recommended that priority be given to defining processes that are justifiable, transparent, and contestable. A discussion of the current situation in Thailand concerning social and ethical analysis of health technologies is also presented. PMID:24964703

  5. Final Technical Report - Center for Technology for Advanced Scientific Component Software (TASCS)

    Energy Technology Data Exchange (ETDEWEB)

    Sussman, Alan [University of Maryland

    2014-10-21

    This is a final technical report for the University of Maryland work in the SciDAC Center for Technology for Advanced Scientific Component Software (TASCS). The Maryland work focused on software tools for coupling parallel software components built using the Common Component Architecture (CCA) APIs. Those tools are based on the Maryland InterComm software framework that has been used in multiple computational science applications to build large-scale simulations of complex physical systems that employ multiple separately developed codes.

  6. DECISION ANALYSIS AND TECHNOLOGY ASSESSMENTS FOR METAL AND MASONRY DECONTAMINATION TECHNOLOGIES

    International Nuclear Information System (INIS)

    The purpose of this investigation was to conduct a comparative analysis of innovative technologies for the non-aggressive removal of coatings from metal and masonry surfaces and the aggressive removal of one-quarter to one-inch thickness of surface from structural masonry. The technologies tested should be capable of being used in nuclear facilities. Innovative decontamination technologies are being evaluated under standard, non-nuclear conditions at the FIU-HCET technology assessment site in Miami, Florida. This study is being performed to support the OST, the Deactivation and Decommissioning (D and D) Focus Area, and the environmental restoration of DOE facilities throughout the DOE complex by providing objective evaluations of currently available decontamination technologies

  7. Technology and Economic Assessment of Innovative Field Drainage Technologies in Denmark

    DEFF Research Database (Denmark)

    Gachango, Florence Gathoni

    Framework Directive (EU WFD), introduced to address the water quality problem the situation calls for solutions that would reconcile these two conflicting issues. “End-of-pipe” filter technologies that would disconnect agricultural drainage pathway before it gets to the aquatic environment have been...... proposed as appropriate solutions to this problem in the Danish context. The feasibility of these technologies with regards to their cost-effectiveness in nutrient mitigation, farmers’ adoption behavior, and environmental policy implementation is assessed in this thesis. The thesis comprises of four papers...... technologies, and their willingness and extent of trading-off the existing farm management nutrient reduction measures with constructed wetland technology, iii) the cost-effectiveness of surface flow constructed wetlands, and iv) the strategies of incorporating the filter technologies into policy measures...

  8. A strategic assessment of cervical cancer prevention and treatment services in 3 districts of Uttar Pradesh, India

    Directory of Open Access Journals (Sweden)

    Dzuba Ilana

    2005-12-01

    Full Text Available Abstract Background Despite being a preventable disease, cervical cancer claims the lives of almost half a million women worldwide each year. India bears one-fifth of the global burden of the disease, with approximately 130,000 new cases a year. In an effort to assess the need and potential for improving the quality of cervical cancer prevention and treatment services in Uttar Pradesh, a strategic assessment was conducted in three of the state's districts: Agra, Lucknow, and Saharanpur. Methods Using an adaptation of stage one of the World Health Organization's Strategic Approach to Improving Reproductive Health Policies and Programmes, an assessment of the quality of cervical cancer services was carried out by a multidisciplinary team of stakeholders. The assessment included a review of the available literature, observations of services, collection of hospital statistics and the conduct of qualitative research (in-depth interviews and focus group discussions to assess the perspectives of women, providers, policy makers and community members. Results There were gaps in provider knowledge and practices, potentially attributable to limited provider training and professional development opportunities. In the absence of a state policy on cervical cancer, screening of asymptomatic women was practically absent, except in the military sector. Cytology-based cancer screening tests (i.e. pap smears were often used to help diagnose women with symptoms of reproductive tract infections but not routinely screen asymptomatic women. Access to appropriate treatment of precancerous lesions was limited and often inappropriately managed by hysterectomy in many urban centers. Cancer treatment facilities were well equipped but mostly inaccessible for women in need. Finally, policy makers, community members and clients were mostly unaware about cervical cancer and its preventable nature, although with information, expressed a strong interest in having services

  9. The study of the life cycle of technology assessment model

    Institute of Scientific and Technical Information of China (English)

    SHEN Yu-Zhi; HUANG Xun-jiang

    2001-01-01

    The life cycle of technology is one of the most important indexes to weigh up the risk of the investment to neo-tech. There are so many uncertainties because it is conditioned by a lot of factors, we can not make a rational forecasting by traditional assessment method. So this paper gives a conprehensive consideration to the factors that influence production and makes some modification to production function, and establishes the life cycle of technology assessmet model by the method of fuzzy mathematics. So it quantifies the risk of investment. We can take it as one foundational index for the decision making of the investment.

  10. Processes of technology assessment: The National Transportation Safety Board

    Science.gov (United States)

    Weiss, E.

    1972-01-01

    The functions and operations of the Safety Board as related to technology assessment are described, and a brief history of the Safety Board is given. Recommendations made for safety in all areas of transportation and the actions taken are listed. Although accident investigation is an important aspect of NTSB's activity, it is felt that the greatest contribution is in pressing for development of better accident prevention programs. Efforts of the Safety Board in changing transportation technology to improve safety and prevent accidents are illustrated.

  11. Human factors assessments of D and D technologies

    International Nuclear Information System (INIS)

    On April 2, 1997, the US Secretary of Energy directed the US Assistant Secretary of Environmental Management and of Safety and Health to require field input of appropriate data to ensure that safety and health considerations were properly addressed in the Accelerating Cleanup: Focus on 2006 Plan. The US Department of Energy (DOE) field managers have committed to the Secretary that they will fully implement integrated safety management systems (ISMSs) at their respective sites by the end of fiscal year 1999. The Secretary has further directed that headquarters safety and health guidance be developed to support consistent and comprehensive project baseline summaries from the field. The Secretary has committed to institutionalizing ISMS as an integral component of the way the DOE conducts its business. The Defense Nuclear Facilities Safety Board continues to oversee and closely monitor the DOE's commitment to the safety and health of its workers. The DOE is committed to a management system approach to ensure that work is performed in a manner that protects the worker, public, and environment. The Deactivation and Decommissioning Focus Area (DDFA) is actively addressing the need to incorporate environmental safety and health (ES and H) considerations in developing technologies. The DDFA is partnered with the Operating Engineers National Hazmat Program (OENHP) to evaluate the ES and H considerations of the innovative and improved decontamination and decommissioning technologies. Part of the implementation of the ES and H work practices in the field is through a cooperative agreement between the National Energy Technology Laboratory (NETL) and the OENHP. The objective of this program is to establish an International Environmental Technology and Training Center to conduct human factors assessments and protocols on environmental technologies. The intent of the human factors assessments is to enhance the effectiveness and efficiency of the technologies and to enhance

  12. Large Deployable Reflector (LDR) system concept and technology definition study. Volume 2: Technology assessment and technology development plan

    Science.gov (United States)

    Agnew, Donald L.; Jones, Peter A.

    1989-01-01

    A study was conducted to define reasonable and representative LDR system concepts for the purpose of defining a technology development program aimed at providing the requisite technological capability necessary to start LDR development by the end of 1991. This volume presents thirteen technology assessments and technology development plans, as well as an overview and summary of the LDR concepts. Twenty-two proposed augmentation projects are described (selected from more than 30 candidates). The five LDR technology areas most in need of supplementary support are: cryogenic cooling; astronaut assembly of the optically precise LDR in space; active segmented primary mirror; dynamic structural control; and primary mirror contamination control. Three broad, time-phased, five-year programs were synthesized from the 22 projects, scheduled, and funding requirements estimated.

  13. The Conversations About Cancer (CAC) project: assessing feasibility and audience impacts from viewing The Cancer Play.

    Science.gov (United States)

    Beach, Wayne A; Buller, Mary K; Dozier, David M; Buller, David B; Gutzmer, Kyle

    2014-01-01

    Basic communication research has identified a major social problem: communicating about cancer from diagnosis through death of a loved one. Over the past decade, an award-winning investigation into how family members talk through cancer on the telephone, based on a corpus of 61 phone calls over a period of 13 months, has been transformed into a theatrical production entitled The Cancer Play. All dialogue in the play is drawn from naturally occurring (transcribed) interactions between family members as they navigate their way through the trials, tribulations, hopes, and triumphs of a cancer journey. This dramatic performance explicitly acknowledges the power of the arts as an exceptional learning tool for extending empirical research, exploring ordinary family life, and exposing the often taken-for-granted conceptions of health and illness. In this study, a Phase I STTR project funded by the National Cancer Institute (NCI), we assess the feasibility of educating and impacting cancer patients, family members, and medical professionals who viewed the play as a live performance and through DVD screenings. Pre- and postperformance questionnaires were administered to solicit audience feedback. Pre-post change scores demonstrate overwhelming and positive impacts for changing opinions about the perceived importance, and attributed significance, of family communication in the midst of cancer. Paired-sample t-tests were conducted on five factor-analyzed indices/indicators-two indices of opinions about cancer and family communication, two indices measuring the importance of key communication activities, and the self-efficacy indicator-and all factors improved significantly (academic and health care professions are discussed. PMID:24098921

  14. Idaho National Laboratory Technology to Market (T2M) Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Wright, Christopher Todd [Idaho National Laboratory; Bush, Jason William [Idaho National Laboratory; Gentle, Jake Paul [Idaho National Laboratory; Hill, Porter Jack [Idaho National Laboratory; Myers, Kurt Steven [Idaho National Laboratory; Williams, Christopher Luke [Idaho National Laboratory

    2016-01-01

    RESEARCHER COMMERCIALIZATION TRAINING FOR NATIONAL LABORATORY RESEARCHERS Project Objectives: Establish a tiered Technology to Market (T2M) curriculum for basic researchers to project leads to measure the effect of technology transfer skills on project success and impact. The plan will train five researchers in basic technology transfer principles where success will be measured by assessing improvements in T2M skills and knowledge after the training is complete, likely using before and after surveys. Activity Description: Develop and deliver in-house training for five key researchers involved in Energy Efficiency and Renewable Energy (EERE) programs to include: • Understanding commercialization process and core principles • Identifying industry need/receptiveness for technology adoption • Identifying technology and commercialization networks • Recognizing intellectual property deployment processes • Understanding delivery options for technology such as Cooperative Research and Development Agreements (CRADA), Work for Others, licensing, spin-off businesses, and technology-based economic development agreements. Activity Goal: Increase researcher understanding of technology transfer and marketing principles that influence developing research products for commercialization.

  15. Assessment of uncertainties in risk analysis of chemical establishments. The ASSURANCE project. Final summary report

    DEFF Research Database (Denmark)

    Lauridsen, K.; Kozine, Igor; Markert, Frank;

    2002-01-01

    This report summarises the results obtained in the ASSURANCE project (EU contract number ENV4-CT97-0627). Seven teams have performed risk analyses for the same chemical facility, an ammonia storage. The EC's Joint Research Centre at Ispra and RisøNational Laboratory co-ordinated the exercise and...... ranking among the adherents of the probabilistic approach. Breaking down the modelling of both frequencyand consequence assessments into suitably small elements and conducting case studies allowed identifying root causes of uncertainty in the final risk assessments. Large differences were found in both...... the frequency assessments and in the assessment ofconsequences. The report gives a qualitative assessment of the importance to the final calculated risk of uncertainties in assumptions made, in the data and the calculation methods used. This assessment can serve as a guide to areas where, in...

  16. FINAL REPORT ON THE AQUATIC MERCURY ASSESSMENT STUDY

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, N

    2008-09-30

    In February 2000, the United States Environmental Protection Agency (EPA) Region 4 issued a proposed Total Maximum Daily Load (TMDL) for total mercury in the middle and lower Savannah River. The initial TMDL, which would have imposed a 1 ng/l mercury limit for discharges to the middle/lower Savannah River, was revised to 2.8 ng/l in the final TMDL released in February 2001. The TMDL was intended to protect people from the consumption of contaminated fish, which is the major route of mercury exposure to humans. The most bioaccumulative form of mercury is methylmercury, which is produced in aquatic environments by the action of microorganisms on inorganic mercury. Because of the environmental and economic significance of the mercury discharge limits that would have been imposed by the TMDL, the Savannah River Site (SRS) initiated several studies concerning: (1) mercury in SRS discharges, SRS streams and the Savannah River, (2) mercury bioaccumulation factors for Savannah River fish, (3) the use of clams to monitor the influence of mercury from tributary streams on biota in the Savannah River, and (4) mercury in rainwater falling on the SRS. The results of these studies are presented in detail in this report. The first study documented the occurrence, distribution and variation of total and methylmercury at SRS industrial outfalls, principal SRS streams and the Savannah River where it forms the border with the SRS. All of the analyses were performed using the EPA Method 1630/31 ultra low-level and contaminant-free techniques for measuring total and methylmercury. Total mercury at National Pollutant Discharge Elimination System (NPDES) outfalls ranged from 0.31-604 ng/l with a mean of 8.71 ng/l. Mercury-contaminated groundwater was the source for outfalls with significantly elevated mercury concentrations. Total mercury in SRS streams ranged from 0.95-15.7 ng/l. Mean total mercury levels in the streams varied from 2.39 ng/l in Pen Branch to 5.26 ng/l in Tims Branch

  17. Imaging techniques used for the real-time assessment of angiogenesis in digestive cancers

    DEFF Research Database (Denmark)

    Saftoiu, Adrian; Vilmann, Peter; Săftoiu, Adrian

    2011-01-01

    evaluation, but also on sensitive monitoring of microvascular changes during treatment. State-of-the-art imaging techniques have the potential to visualize and characterize angiogenesis, although the technology and methodologies employed are recent and need further validation. The aim of this series of...... reviews was to analyze and enhance current knowledge and future perspectives about the real-time assessment of angiogenesis in digestive cancers, used for the longitudinal monitoring of the effects of chemo-radiotherapy (including anti-angiogenic therapies), as well as for the precise targeting of drugs...

  18. Stem cell technology and engineering for cancer treatment

    OpenAIRE

    Sinh Truong Nguyen; Phuc Van Pham

    2015-01-01

    Stem cells are not only widely used for regenerative medicine, but are also considered as a useful tool for cancer treatment. For a long time, stem cells have been utilized to renew the immune system for radiation or chemotherapy treated patients. Recently, stem cells are being engineered to carry therapeutic reagents to target tumor sites. Cancer vaccines based on the knowledge of cancer stem cells have been studied and applied for cancer treatment. Induced pluripotent stem cells have been u...

  19. Final amended report on the safety assessment of Mink Oil.

    Science.gov (United States)

    2005-01-01

    Mink Oil, obtained from the fatty tissues of minks, is a mixture of the natural glycerides of 14 to 20 carbon chain fatty acids. There are 100 current reported uses as a hair-conditioning agent, an occlusive skin-conditioning agent, and as a surfactant; up to a maximum concentration of 3%. Mink Oil is manufactured by harvesting animal hides and scraping the fat layer from the hide. It is rendered and refined using high temperature processes (230 degrees F to 240 degrees F) and saponification to reduce free fatty acids. Analyses demonstrate that Mink Oil can be substantially free of impurities, including pesticides. Mink Oil does not absorb significant UVA or UVB radiation. In a clinical test of skin penetration, 1 h after application, Mink Oil was detected on the skin surface of all five panelists; it was detected within the stratum corneum in 2/5 panelists. Mink Oil has an oral LD50 of > 64.0 cc/kg in albino rats. No erythema or edema was noted after refined Mink Oil was applied for 24 h to intact and scarified area of albino rabbits. A 50% dilution of a Mink Oil cream did not sensitize guinea pigs in a maximization test. Mink Oil was not an ocular irritant to albino rabbits. Clinical studies using single occlusive patches found no irritation with up to 2.8% Mink Oil, although transient mild to no irritation was noted in two exaggerated-use studies. Mink Oil is used in aerosols and sprays. Although there are no inhalation toxicity data available on Mink Oil, the available data on particle sizes of cosmetic aerosols and sprays indicates diameters more than an order of magnitude larger than the diameter of respirable particles. Most of the glycerides in Mink Oil are triglycerides (glyceryl triesters), the safety of which has been substantiated in previous safety assessments; e.g., dermal absorption is nil to slight; there is little or no acute, subchronic, or chronic oral toxicity; dermal application was not associated with significant irritation or sensitization

  20. Text mining for literature review and knowledge discovery in cancer risk assessment and research.

    Directory of Open Access Journals (Sweden)

    Anna Korhonen

    Full Text Available Research in biomedical text mining is starting to produce technology which can make information in biomedical literature more accessible for bio-scientists. One of the current challenges is to integrate and refine this technology to support real-life scientific tasks in biomedicine, and to evaluate its usefulness in the context of such tasks. We describe CRAB - a fully integrated text mining tool designed to support chemical health risk assessment. This task is complex and time-consuming, requiring a thorough review of existing scientific data on a particular chemical. Covering human, animal, cellular and other mechanistic data from various fields of biomedicine, this is highly varied and therefore difficult to harvest from literature databases via manual means. Our tool automates the process by extracting relevant scientific data in published literature and classifying it according to multiple qualitative dimensions. Developed in close collaboration with risk assessors, the tool allows navigating the classified dataset in various ways and sharing the data with other users. We present a direct and user-based evaluation which shows that the technology integrated in the tool is highly accurate, and report a number of case studies which demonstrate how the tool can be used to support scientific discovery in cancer risk assessment and research. Our work demonstrates the usefulness of a text mining pipeline in facilitating complex research tasks in biomedicine. We discuss further development and application of our technology to other types of chemical risk assessment in the future.

  1. Fusion reactor physics and technology studies: Final report, December 1, 1985 to June 15, 1986

    International Nuclear Information System (INIS)

    The work performed for ''Fusion Reactor Physics and Technology Studies'' was to participate with Lawrence Livermore National Laboratory (LLNL) and others in the design of the Minimars Tandem Mirror power reactor. This design activity was a collaborative effort with LLNL being responsible for the physics and program administration. The Fusion Technology Institute (FTI) of the University of Wisconsin was responsible for nuclear technology (central cell blanket/reflector/shield design, neutronics, activation, tritium issues, and end cell shielding), and the design of the central cell magnets. In addition, FTI provided assistance to LLNL on the plasma physics modeling of the plasma halo. An interim report on the Minimars design has been issued, and a final report covering all aspects of Minimars is in press. In addition, various reports and conference papers covering aspects of the design have been issued, and are listed in this report. A summary of the FTI contribution to the Minimars design study is presented

  2. The nutritional assessment of head and neck cancer patients.

    Science.gov (United States)

    Magnano, Mauro; Mola, Patrizia; Machetta, Giacomo; Maffeis, Paola; Forestiero, Ilenia; Cavagna, Roberta; Artino, Elena; Boffano, Paolo

    2015-12-01

    Patients affected by head and neck cancer are particularly at risk for nutritional depletion. The aim of this study was to evaluate the nutritional status of patients affected by head and neck cancer at diagnosis. All adult patients with head and neck cancer between January 2009 and December 2013 were included. The following data were recorded: demographics, tobacco and/or alcohol consumption, weight, height, the reference weight 6 months before the diagnosis, tumor site, tumor stage, and laboratory data. Then, Body mass index (BMI), and Buzby nutrition risk index (NRI) were calculated. Statistical analysis was used to search for associations among multiple variables. 122 men and 22 women were enrolled. As for reference BMI, 77 patients were overweight, whereas just 7 subjects were underweight. At diagnosis, 72 subjects were overweight according to BMI, whereas 52 patients were underweight. Instead, according to NRI, 96 patients were severely malnourished, 42 patients were moderately malnourished, whereas just 6 patients had a normal value of NRI. The assessment of nutrition by BMI excluded from a thorough consideration all overweight and obese patients with head and neck cancer. Instead, NRI correctly identified both undernourished and overweight/obese patients as "malnourished" subjects. PMID:25534287

  3. Hospital Based Health Technology Assessment: an example from Siena

    Directory of Open Access Journals (Sweden)

    Pietro Manzi

    2015-03-01

    Full Text Available The Health Technology Assessment (HTA has emerged in recent years as a useful tool in healthcare decision-making. It is a multidisciplinary process that summarizes information about the medical, social, economic and ethical issues related to the use of a health technology and provides evidence-based information on how to allocate resources. The experience of Siena University Hospital is an example of multidisciplinary hospital-based HTA. In the present paper we summarize the organization of HTA commission and the assessment methodology of the purchase, rental or sale of medical equipment and medical devices. Furthermore we illustrate the data concerning the commission activities in 2013.http://dx.doi.org/10.7175/fe.v16i1.943

  4. International conference on comparative assessments of solar power technologies

    International Nuclear Information System (INIS)

    Many regions in the world which lack fossil fuel resources but possess ample sunshine seek to identify near-term solar technologies capable of gradually replacing their fuel imports in cost-effective fashion. The conference addresses the following topics: technical and economical studies specifying their underlying basic assumption, methods and rules for evaluation in order to enable meaningful comparison between different technologies and systems. Detailed delineation of numerical and graphical representations, critical analysis and comparison between simulations, and test validity. Generalized performance indicators for systems and subsystems, problems of measuring and evaluating physical parameters, of terminology and conceptual tools for comparative evaluations. Advances in research development, engineering and field performance, including implications pertaining to comparative assessments and definitions of criteria and standards helpful to comparative evaluation. Assessments of the full (and hidden) cost of fossil energies as compared to solar, including environmental costs. Cost/benefit studies for remote versus centralized systems. (ed.)

  5. Environmental assessment of solid waste systems and technologies: EASEWASTE

    DEFF Research Database (Denmark)

    Kirkeby, Janus Torsten; Birgisdottir, Harpa; Hansen, Trine Lund;

    2006-01-01

    A new model has been developed for evaluating the overall resource consumption and environmental impacts of municipal solid waste management systems by the use of life cycle assessment. The model is named EASEWASTE (Environmental Assessment of Solid Waste Systems and Technologies) and is able...... to compare different waste management strategies, waste treatment methods and waste process technologies. The potential environmental impacts can be traced back to the most important processes and waste fractions that contribute to the relevant impacts. A model like EASEWASTE can be used by waste planners...... may not always be the most environmentally friendly. The EASEWASTE model can identify the most environmentally sustainable solution, which may differ among waste materials and regions and can add valuable information about environmental achievements from each process in a solid waste management system....

  6. Identification and assessment of site treatment plan implementation opportunities for emerging technologies

    Energy Technology Data Exchange (ETDEWEB)

    Bernard, E.A. [Sandia National Labs., Germantown, MD (United States)

    1995-12-31

    The Department of Energy (DOE), in response to the 1992 Federal Facility Compliance Act, has prepared Site Treatment Plans (STP) for the approximately 2,000 waste streams identified within its mixed waste inventory Concurrently, emerging mixed waste treatment technologies are in final development. This paper defines a three-phase process to identify and assess implementation opportunities for these emerging technologies within the STP. It highlights the first phase, functional matching of expected treatment capabilities with proposed treatment requirements. Matches are based on treatment type, regulated contaminant and waste matrix type, for both capabilities and requirements. Results identify specific waste streams and volumes that could be treated by each emerging technology. A study for Plasma Hearth Process, Delphi DETOX{sup sm}, Supercritical Water Oxidation and Vitrification shows that about 200,000 ml of DOE`s mixed waste inventory can potentially be treated by one or more of these emerging technologies. Actual implementations are small fractions of the treatable inventory. Differences between potential and actual implementations must be minimized to accrue optimum benefit from implementation of emerging or alternative treatment technologies. Functional matching is the first phase in identifying and quantifying benefits, addressing technology system and treatment issues, and providing, in part, the basis for STP implementation decisions. DOE, through EM`s Office of Technology Development, has funded this work.

  7. Identification and assessment of site treatment plan implementation opportunities for emerging technologies

    International Nuclear Information System (INIS)

    The Department of Energy (DOE), in response to the 1992 Federal Facility Compliance Act, has prepared Site Treatment Plans (STP) for the approximately 2,000 waste streams identified within its mixed waste inventory Concurrently, emerging mixed waste treatment technologies are in final development. This paper defines a three-phase process to identify and assess implementation opportunities for these emerging technologies within the STP. It highlights the first phase, functional matching of expected treatment capabilities with proposed treatment requirements. Matches are based on treatment type, regulated contaminant and waste matrix type, for both capabilities and requirements. Results identify specific waste streams and volumes that could be treated by each emerging technology. A study for Plasma Hearth Process, Delphi DETOXsm, Supercritical Water Oxidation and Vitrification shows that about 200,000 ml of DOE's mixed waste inventory can potentially be treated by one or more of these emerging technologies. Actual implementations are small fractions of the treatable inventory. Differences between potential and actual implementations must be minimized to accrue optimum benefit from implementation of emerging or alternative treatment technologies. Functional matching is the first phase in identifying and quantifying benefits, addressing technology system and treatment issues, and providing, in part, the basis for STP implementation decisions. DOE, through EM's Office of Technology Development, has funded this work

  8. Assessing the Application of Tissue Microarray Technology to Kidney Research

    OpenAIRE

    Zhang, Ming-Zhi; Su, Yinghao; Yao, Bing; Zheng, Wei; deCaestecker, Mark; Harris, Raymond C.

    2010-01-01

    Tissue microarray (TMA) is a new high-throughput method that enables simultaneous analysis of the profiles of protein expression in multiple tissue samples. TMA technology has not previously been adapted for physiological and pathophysiological studies of rodent kidneys. We have evaluated the validity and reliability of using TMA to assess protein expression in mouse and rat kidneys. A representative TMA block that we have produced included: (1) mouse and rat kidney cortex, outer medulla, and...

  9. Environmental measurements and technology for non-proliferation objectives. Final report

    International Nuclear Information System (INIS)

    The purpose of this study is to identify multi-disciplinary and single focus laboratories from the environmental and public health communities that can serve as technical center of opportunity for nuclear, inorganic and organic analyses. The objectives of the Office of Research and Development effort are twofold: (1) to identify the technology shortcomings and technologies gaps (thus requirements) within these communities that could benefit from state-of-the-art infield analysis technologies currently under development and (2) to promote scientist-to-scientist dialog and technical exchange under such existing US government internship programs (eg SABIT/USDOC) to improve skills and work relationships. Although the data analysis will focus on environmentally sensitive signatures and materials, the office of Research and Development wishes to further its nuclear non-proliferation objectives by assessing the current technical skill and ingenious analytical tools in less-developed countries so as to broaden the base of capability for multi-species measurement technology development

  10. Teacher Learning of Technology-Enhanced Formative Assessment

    CERN Document Server

    Beatty, Ian D; Leonard, William J; Gerace, William J; Cyr, Karen St; Lee, Hyunju; Harris, Robby

    2008-01-01

    Technology-Enhanced Formative Assessment (TEFA) is a pedagogy for teaching with classroom response technology. Teacher Learning of TEFA is a five-year research project studying teacher change, in the context of an intensive professional development program designed to help science and mathematics teachers learn TEFA. First, we provide an overview of the project's participating teachers, its intervention (consisting of the technology, the pedagogy, and the professional development program), and its research design. Then, we present narratives describing the unfolding change process experienced by four teachers. Afterward, we present some preliminary findings of the research, describe a "model for the co-evolution of teacher and pedagogy" that we are developing, and identify general implications for professional development.

  11. Technical and economic assessment of energy conversion technologies for MSW

    International Nuclear Information System (INIS)

    Thermal processes for municipal solid wastes (MSW) based on pyrolysis and/or gasification that have relevance to the emerging UK market are described in this report, and the results of the technical and economical assessment of these processes are presented. The Mitsui R21 Technology, the Thermoselect Process, the Nippon Steel Waste Melting Process, the Pyropleq Process, and the Compact Power Process are selected for detailed comparison on the basis of the overall technical concept, the energy balance and the requirements for consumables, environmental performance, and the technical and commercial status of the technology. Details are also given of a comparison of the novel thermal technologies with conventional mass burn incineration for MSW

  12. Preliminary nuclear power reactor technology qualitative assessment for Malaysia

    International Nuclear Information System (INIS)

    Since the worlds first nuclear reactor major breakthrough in December 02, 1942, the nuclear power industry has undergone tremendous development and evolution for more than half a century. After surpassing moratorium of nuclear power plant construction caused by catastrophic accidents at Three-mile island (1979) and Chernobyl (1986), today, nuclear energy is back on the policy agendas of many countries, both developed and developing, signaling nuclear revival or nuclear renaissance. Selection of suitable nuclear power technology has thus been subjected to primary attention. This short paper attempts to draw preliminary technology assessment for the first nuclear power reactor technology for Malaysia. Methodology employed is qualitative analysis collating recent finding of tnb-kepco preliminary feasibility study for nuclear power program in peninsular malaysia and other published presentations and/or papers by multiple experts. The results suggested that pressurized water reactor (PWR) is the prevailing technology in terms of numbers and plant performances, and while the commercialization of generation IV reactors is remote (e.g. Not until 2030), generation III/ III+ NPP models are commercially available on the market today. Five (5) major steps involved in reactor technology selection were introduced with a focus on introducing important aspects of selection criteria. Three (3) categories for the of reactor technology selection were used for the cursory evaluation. The outcome of these analyses shall lead to deeper and full analyses of the recommended reactor technologies for a comprehensive feasibility study in the near future. Recommendations for reactor technology option were also provided for both strategic and technical recommendations. The paper shall also implore the best way to select systematically the first civilian nuclear power reactor. (Author)

  13. Health-care technology assessment: a clinical perspective.

    Science.gov (United States)

    Chantler, Cyril

    2004-01-01

    Health technology assessment needs to relate to contemporary questions which concern public health-care systems: how to keep people healthy, how to focus on the needs of those with chronic disabilities and integrate care between the hospital and the community, how to encourage and audit effective teamwork, and how to establish a consensus about what is effective and affordable. Clinicians have an ethical responsibility to practice efficiently and economically, for profligacy in the care of one patient may mean that another is treated inadequately. For similar reasons, clinicians need to play a full role in the management of services. Advice from health technology assessment is vital and needs to be accurate, relevant, timely, clear, and accessible. As well as being concerned about what works, we need also to eliminate from practice what does not. Regular audit and appraisal of practice against the evidence base should be useful in this respect. Alternative approaches to management, such as the provision of care as opposed to aggressive treatments, need to be evaluated, and health technology assessment needs to consider how services are delivered, not just specific treatments. PMID:15176183

  14. National Wind Technology Center sitewide, Golden, CO: Environmental assessment

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-01

    The National Renewable Energy Laboratory (NREL), the nation`s primary solar and renewable energy research laboratory, proposes to expand its wind technology research and development program activities at its National Wind Technology Center (NWTC) near Golden, Colorado. NWTC is an existing wind energy research facility operated by NREL for the US Department of Energy (DOE). Proposed activities include the construction and reuse of buildings and facilities, installation of up to 20 wind turbine test sites, improvements in infrastructure, and subsequent research activities, technology testing, and site operations. In addition to wind turbine test activities, NWTC may be used to support other NREL program activities and small-scale demonstration projects. This document assesses potential consequences to resources within the physical, biological, and human environment, including potential impacts to: air quality, geology and soils, water resources, biological resources, cultural and historic resources, socioeconomic resources, land use, visual resources, noise environment, hazardous materials and waste management, and health and safety conditions. Comment letters were received from several agencies in response to the scoping and predecisional draft reviews. The comments have been incorporated as appropriate into the document with full text of the letters contained in the Appendices. Additionally, information from the Rocky Flats Environmental Technology Site on going sitewide assessment of potential environmental impacts has been reviewed and discussed by representatives of both parties and incorporated into the document as appropriate.

  15. National Wind Technology Center sitewide, Golden, CO: Environmental assessment

    International Nuclear Information System (INIS)

    The National Renewable Energy Laboratory (NREL), the nation's primary solar and renewable energy research laboratory, proposes to expand its wind technology research and development program activities at its National Wind Technology Center (NWTC) near Golden, Colorado. NWTC is an existing wind energy research facility operated by NREL for the US Department of Energy (DOE). Proposed activities include the construction and reuse of buildings and facilities, installation of up to 20 wind turbine test sites, improvements in infrastructure, and subsequent research activities, technology testing, and site operations. In addition to wind turbine test activities, NWTC may be used to support other NREL program activities and small-scale demonstration projects. This document assesses potential consequences to resources within the physical, biological, and human environment, including potential impacts to: air quality, geology and soils, water resources, biological resources, cultural and historic resources, socioeconomic resources, land use, visual resources, noise environment, hazardous materials and waste management, and health and safety conditions. Comment letters were received from several agencies in response to the scoping and predecisional draft reviews. The comments have been incorporated as appropriate into the document with full text of the letters contained in the Appendices. Additionally, information from the Rocky Flats Environmental Technology Site on going sitewide assessment of potential environmental impacts has been reviewed and discussed by representatives of both parties and incorporated into the document as appropriate

  16. Quality-of-life assessment in advanced cancer.

    LENUS (Irish Health Repository)

    Donnelly, S

    2000-07-01

    In the past 5 years, quality-of-life (QOL) assessment measures such as the McGill, McMaster, Global Visual Analogue Scale, Assessment of QOL at the End of Life, Life Evaluation Questionnaire, and Hospice QOL Index have been devised specifically for patients with advanced cancer. The developers of these instruments have tried to respond to the changing needs of this specific population, taking into account characteristics including poor performance status, difficulty with longitudinal study, rapidly deteriorating physical condition, and change in relevant issues. Emphasis has been placed on patient report, ease and speed of completion, and the existential domain or meaning of life. Novel techniques in QOL measurement have also been adapted for palliative care, such as judgment analysis in the Schedule for the Evaluation of Individual Quality of Life. It is generally agreed that a single tool will not cover all QOL assessment needs.

  17. Assessing risks for gastric cancer: New tools for pathologists

    Institute of Scientific and Technical Information of China (English)

    Robert M Genta; Massimo Rugge

    2006-01-01

    Although the Sydney Systems (original and updated) for the classification of gastritis have contributed substantially to the uniformity of the reporting of gastric conditions, they lack immediacy in conveying to the user information about gastric cancer risk. In this review, we summarize the current understanding of the gastric lesions associated with an increased risk for cancer, and present the rationale for a proposal for new ways of reporting gastritis. In addition to the traditional histopathological data gathered and evaluated according to the Sydney System rules, pathologists could add an assessment expressed as grading and staging of the gastric inflammatory and atrophic lesions and integrate these findings with pertinent laboratory information on pepsinogens and gastrin levels. Such an integrated report could facilitate clinicians' approach to the management of patients with gastric conditions.

  18. Technology assessment of various coal-fuel options

    International Nuclear Information System (INIS)

    The technology assessment (TA) study of coal-based fuels presented in this report was performed for the Federal Ministry for Research and Technology. Its goal was to support decision-making of the Federal Ministry for Research and Technology in the field of coal conversion. Various technical options of coal liquefaction have been analyzed on the basis of hard coal as well as lignite -- direct liquefaction of coal (hydrogenation) and different possibilities of indirect liquefaction, that is the production of fuels (methanol, gasoline) by processing products of coal gasification. The TA study takes into consideration the entire technology chain from coal mining via coal conversion to the utilization of coal-based fuels in road transport. The analysis focuses on costs of the various options, overall economic effects, which include effects on employment and public budgets, and on environmental consequences compared to the use of liquid fuels derived from oil. Furthermore, requirements of infrastructure and other problems of the introduction of coal-based fuels as well as prospects for the export of technologies of direct and indirect coal liquefaction have been analyzed in the study. 14 figs., 10 tabs

  19. Battery technology assessment and R and D plan

    Science.gov (United States)

    Henriksen, Gary L.

    To guide future EV battery R and D programs, the U.S. Department of Energy (DOE) commissioned a comprehensive assessment of secondary battery technologies. A total of 67 battery developers -- from the United States, Canada, Europe, Asia, and Africa -- were solicited to submit battery design concepts for an Improved Dual-Shaft Electric Propulsion (IDSEP) van. A team of 10 consultants and 7 representatives from DOE laboratories evaluated 42 developer responses and consultant-prepared designs. Using six criteria -- five technical/economic criteria and a maturity/technical barriers criterion -- the assessment identified 12 most-promising batteries. Employing a generic EV-battery development-process framework, the assessment results were used to formulate multi-year R and D plans and schedules for the most-promising developmental batteries.

  20. Connected Classroom Technology Facilitates Multiple Components of Formative Assessment Practice

    Science.gov (United States)

    Shirley, Melissa L.; Irving, Karen E.

    2015-02-01

    Formative assessment has been demonstrated to result in increased student achievement across a variety of educational contexts. When using formative assessment strategies, teachers engage students in instructional tasks that allow the teacher to uncover levels of student understanding so that the teacher may change instruction accordingly. Tools that support the implementation of formative assessment strategies are therefore likely to enhance student achievement. Connected classroom technologies (CCTs) include a family of devices that show promise in facilitating formative assessment. By promoting the use of interactive student tasks and providing both teachers and students with rapid and accurate data on student learning, CCT can provide teachers with necessary evidence for making instructional decisions about subsequent lessons. In this study, the experiences of four middle and high school science teachers in their first year of implementing the TI-Navigator™ system, a specific type of CCT, are used to characterize the ways in which CCT supports the goals of effective formative assessment. We present excerpts of participant interviews to demonstrate the alignment of CCT with several main phases of the formative assessment process. CCT was found to support implementation of a variety of instructional tasks that generate evidence of student learning for the teacher. The rapid aggregation and display of student learning evidence provided teachers with robust data on which to base subsequent instructional decisions.

  1. An assessment of desiccant cooling and dehumidification technology

    Energy Technology Data Exchange (ETDEWEB)

    Mei, V.C.; Chen, F.C. (Oak Ridge National Lab., TN (United States)); Lavan, Z. (Illinois Inst. of Tech., Chicago, IL (United States)); Collier, R.K. Jr. (Collier Engineering Services, Merritt Island, FL (United States)); Meckler, G. (Gershon Meckler Associates, P.C., Herndon, VA (United States))

    1992-07-01

    Desiccant systems are heat-actuated cooling and dehumidification technology. With the recent advances in this technology, desiccant systems can now achieve a primary energy coefficient of performance (COP) between 1.3 and 1.5, with potential to go to 1.7 and higher. It is becoming one of the most promising alternatives to conventional cooling systems. Two important and well-known advantages of desiccant cooling systems are that they are CFC free and they can reduce the electricity peak load. Another important but lesser-known advantage of desiccant technology is its potential for energy conservation. The energy impact study in this report indicated that a possible 13% energy saving in residential cooling and 8% in commercial cooling is possible. Great energy saving potential also exists in the industrial sector if industrial waste heat can be used for desiccant regeneration. The latest study on desiccant-integrated building heating, ventilating, and air conditioning (HVAC) systems indicated that the initial cost for the conventional cooling equipment was greatly reduced by using desiccant technology because of downsized compressors, fans, and ductworks. This cost reduction was more than enough to offset the cost of desiccant equipment. Besides, the system operation cost was also reduced. All these indicate that desiccant systems are also cost effective. This study provides an updated state-of-the-art assessment forsiccant technology in the field of desiccant materials, systems, computer models, and theoretical analyses. From this information the technology options were derived and the future research and development needs were identified. Because desiccant technology has already been applied in the commercial building sector with very encouraging results, it is expected that future market breakthroughs will probably start in this sector. A market analysis for the commercial building application is therefore included.

  2. Radiation risk models for all solid cancers other than those types of cancer requiring individual assessments after a nuclear accident.

    Science.gov (United States)

    Walsh, Linda; Zhang, Wei

    2016-03-01

    In the assessment of health risks after nuclear accidents, some health consequences require special attention. For example, in their 2013 report on health risk assessment after the Fukushima nuclear accident, the World Health Organisation (WHO) panel of experts considered risks of breast cancer, thyroid cancer and leukaemia. For these specific cancer types, use was made of already published excess relative risk (ERR) and excess absolute risk (EAR) models for radiation-related cancer incidence fitted to the epidemiological data from the Japanese A-bomb Life Span Study (LSS). However, it was also considered important to assess all other types of solid cancer together and the WHO, in their above-mentioned report, stated "No model to calculate the risk for all other solid cancer excluding breast and thyroid cancer risks is available from the LSS data". Applying the LSS models for all solid cancers along with the models for the specific sites means that some cancers have an overlap in the risk evaluations. Thus, calculating the total solid cancer risk plus the breast cancer risk plus the thyroid cancer risk can overestimate the total risk by several per cent. Therefore, the purpose of this paper was to publish the required models for all other solid cancers, i.e. all solid cancers other than those types of cancer requiring special attention after a nuclear accident. The new models presented here have been fitted to the same LSS data set from which the risks provided by the WHO were derived. Although it is known already that the EAR and ERR effect modifications by sex are statistically significant for the outcome "all solid cancer", it is shown here that sex modification is not statistically significant for the outcome "all solid cancer other than thyroid and breast cancer". It is also shown here that the sex-averaged solid cancer risks with and without the sex modification are very similar once breast and thyroid cancers are factored out. Some other notable model

  3. Shear-wave elastography contributes to accurate tumour size estimation when assessing small breast cancers

    International Nuclear Information System (INIS)

    Aim: To assess whether the size of peritumoural stiffness (PTS) on shear-wave elastography (SWE) for small primary breast cancers (≤15 mm) was associated with size discrepancies between grey-scale ultrasound (GSUS) and final histological size and whether the addition of PTS size to GSUS size might result in more accurate tumour size estimation when compared to final histological size. Materials and methods: A retrospective analysis of 86 consecutive patients between August 2011 and February 2013 who underwent breast-conserving surgery for tumours of size ≤15 mm at ultrasound was carried out. The size of PTS stiffness was compared to mean GSUS size, mean histological size, and the extent of size discrepancy between GSUS and histology. PTS size and GSUS were combined and compared to the final histological size. Results: PTS of >3 mm was associated with a larger mean final histological size (16 versus 11.3 mm, p < 0.001). PTS size of >3 mm was associated with a higher frequency of underestimation of final histological size by GSUS of >5 mm (63% versus 18%, p < 0.001). The combination of PTS and GSUS size led to accurate estimation of the final histological size (p = 0.03). The size of PTS was not associated with margin involvement (p = 0.27). Conclusion: PTS extending beyond 3 mm from the grey-scale abnormality is significantly associated with underestimation of tumour size of >5 mm for small invasive breast cancers. Taking into account the size of PTS also led to accurate estimation of the final histological size. Further studies are required to assess the relationship of the extent of SWE stiffness and margin status. - Highlights: • Peritumoural stiffness of greater than 3 mm was associated with larger tumour size. • Underestimation of tumour size by ultrasound was associated with peri-tumoural stiffness size. • Combining peri-tumoural stiffness size to ultrasound produced accurate tumour size estimation

  4. Cancer Inhibitors Isolated from an African Plant | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The National Cancer Institute's Molecular Targets Development Program is seeking parties interested in collaborative research to further develop, evaluate, or commercialize cancer inhibitors isolated from the African plant Phyllanthus englerii. The technology is also available for exclusive or non-exclusive licensing.

  5. Development and Implementation of Health Technology Assessment: A Policy Study

    Directory of Open Access Journals (Sweden)

    P Abooee

    2013-01-01

    Full Text Available Background: To provide an overview of the development of health technology assessment (HTA in Iran since 2007, and to facilitate further development of HTA and its integration into policy making.Methods: Data of this study were collected through key documents (e.g. literature, laws, and other official documentation and analyzed by experts of opinion in form of qualitative methods.Results: Health technology assessment entered to the political agenda in Iran only in 2007 with a strong impetus of an evidence-based medicine movement with the bellow objectives: Institutionalization of evidence-based decision making in Ministry of Health, Creating an localization for structural HTA in Health system of Iran, Setting up training courses in order to educate capable manpower to full up the capacity of the universities, Establishment of a new field in HTA subject in medical universities for MSc and PhD degree, International communication about HTA through national website and possible participation in international Congress.Conclusion: HTA has been established in the healthcare system of Iran but what is needed is a clear political will to push forward the objectives of HTA in Iran. Similar to other countries, advance the regulation on the adoption of new health technologies to improve not only technical or allocate efficiency, but also health equity.

  6. Expanding Health Technology Assessments to Include Effects on the Environment.

    Science.gov (United States)

    Marsh, Kevin; Ganz, Michael L; Hsu, John; Strandberg-Larsen, Martin; Gonzalez, Raquel Palomino; Lund, Niels

    2016-01-01

    There is growing awareness of the impact of human activity on the climate and the need to stem this impact. Public health care decision makers from Sweden and the United Kingdom have started examining environmental impacts when assessing new technologies. This article considers the case for incorporating environmental impacts into the health technology assessment (HTA) process and discusses the associated challenges. Two arguments favor incorporating environmental impacts into HTA: 1) environmental changes could directly affect people's health and 2) policy decision makers have broad mandates and objectives extending beyond health care. Two types of challenges hinder this process. First, the nascent evidence base is insufficient to support the accurate comparison of technologies' environmental impacts. Second, cost-utility analysis, which is favored by many HTA agencies, could capture some of the value of environmental impacts, especially those generating health impacts, but might not be suitable for addressing broader concerns. Both cost-benefit and multicriteria decision analyses are potential methods for evaluating health and environmental outcomes, but are less familiar to health care decision makers. Health care is an important and sizable sector of the economy that could warrant closer policy attention to its impact on the environment. Considerable work is needed to track decision makers' demands, augment the environmental evidence base, and develop robust methods for capturing and incorporating environmental data as part of HTA. PMID:27021760

  7. ALINET: a model for assessing energy conservation opportunities in the food processing industry. Final technical report, September 1977-December 1979

    Energy Technology Data Exchange (ETDEWEB)

    Levis, A H; Ducot, E R; Levis, I S; Webster, T F

    1979-12-01

    ALINET is a network model designed for the analysis of energy use in the food processing and distribution sector and for the evaluation of the potential effectiveness of energy conserving technologies. The conceptual framework of the model, as well as the design and implementation of the computer software are described. The wheat system at the national, state, and facility-specific level is used to illustrate the model's operation and use. A pilot project, carried out in cooperation with industry, is described in which energy use in (a) hard wheat milling, and (b) durum milling and pasta manufacture is analyzed. Finally, the introduction of an alternative technology for pasta drying is assessed in terms of energy conservation and cost. Recommendation for further applications and institutionalization of the model are made.

  8. Evaluative studies in nuclear medicine research: positron computed tomography assessment. Final report, January 1, 1982-December 31, 1982

    International Nuclear Information System (INIS)

    Results are reported of the final phase of the study effort generally titled Evaluative Studies in Nuclear Medicine Research. The previous work is reviewed and extended to an assessment providing perspectives on medical applications of positron emission tomographic (PET) systems, their technological context, and the related economic and marketing environment. Methodologies developed and used in earlier phases of the study were continued, but specifically extended to include solicitation of opinion from commercial organizations deemed to be potential developers, manufacturers and marketers of PET systems. Several factors which influence the demand for clinical uses of PET are evaluated and discussed. The recent Federal funding of applied research with PET systems is found to be a necessary and encouraging event toward a determination that PET either is a powerful research tool limited to research, or whether it also presents major clinical utility. A comprehensive, updated bibliography of current literature related to the development, applications and economic considerations of PET technology is appended

  9. The Local Influence of Pioneer Investigators on Technology Adoption: Evidence from New Cancer Drugs

    OpenAIRE

    Leila Agha; David Molitor

    2015-01-01

    Local opinion leaders may play a key role in easing information frictions associated with technology adoption. This paper analyzes the influence of physician investigators who lead pivotal clinical trials for new cancer drugs. By comparing diffusion patterns across many drugs, we separate correlated regional demand for new technology from information spillovers. Using original data on clinical trial study authors for 21 new cancer drugs along with Medicare claims data from 1998-2008, we find ...

  10. Access to communication technologies in a sample of cancer patients: an urban and rural survey

    OpenAIRE

    Perkins Anthony; Butler Donna; Kroenke Kurt; Theobald Dale E; Abdullah Ma'n; Edgerton Sara; Dugan William M

    2005-01-01

    Abstract Background There is a growing awareness among providers of the symptom burden experienced by cancer patients. Systematic symptom screening is difficult. Our plan was to evaluate a technology-based symptom screening process using touch-tone telephone and Internet in our rural outreach cancer program in Indiana. Would rural patients have adequate access to technologies for home-based symptom reporting? Objectives 1) To determine access to touch-tone telephone service and Internet for p...

  11. Prioritization of tasks in the draft LWR safety technology program plan. Final report

    International Nuclear Information System (INIS)

    The purpose of this report is to describe both the approach taken and the results produced in the SAI effort to prioritize the tasks in the Sandia draft LWR Safety Technology Program Plan. This work used the description of important safety issues developed in the Reactor Safety Study (2) to quantify the effect of safety improvements resulting from a research and development program on the risk from nuclear power plants. Costs of implementation of these safety improvements were also estimated to allow a presentation of the final results in a value (i.e., risk reduction) vs. impact (i.e., implementation costs) matrix

  12. Screening for colorectal cancer: possible improvements by risk assessment evaluation?

    Science.gov (United States)

    Nielsen, Hans J; Jakobsen, Karen V; Christensen, Ib J; Brünner, Nils

    2011-11-01

    Emerging results indicate that screening improves survival of patients with colorectal cancer. Therefore, screening programs are already implemented or are being considered for implementation in Asia, Europe and North America. At present, a great variety of screening methods are available including colono- and sigmoidoscopy, CT- and MR-colonography, capsule endoscopy, DNA and occult blood in feces, and so on. The pros and cons of the various tests, including economic issues, are debated. Although a plethora of evaluated and validated tests even with high specificities and reasonable sensitivities are available, an international consensus on screening procedures is still not established. The rather limited compliance in present screening procedures is a significant drawback. Furthermore, some of the procedures are costly and, therefore, selection methods for these procedures are needed. Current research into improvements of screening for colorectal cancer includes blood-based biological markers, such as proteins, DNA and RNA in combination with various demographically and clinically parameters into a "risk assessment evaluation" (RAE) test. It is assumed that such a test may lead to higher acceptance among the screening populations, and thereby improve the compliances. Furthermore, the involvement of the media, including social media, may add even more individuals to the screening programs. Implementation of validated RAE and progressively improved screening methods may reform the cost/benefit of screening procedures for colorectal cancer. Therefore, results of present research, validating RAE tests, are awaited with interest. PMID:21854094

  13. Current aspects of radiation-induced cancer risk assessment

    International Nuclear Information System (INIS)

    The agenda of the closed meeting of the commission shows the following main topics: 1) Recent dosimetry /Ro 87/ and new data on cancer mortality in the Atomic Bomb survivors of Hiroshima and Nagasaki as a function of age at the time of exposure /Pr 87; Si 87; IC 87.1/. 2) Models and assumptions given in the epidemiological tables of the U.S. National Institute of Health (NIH) /NIH 85/ for assessment of probability of cancer induction due to exposure to ionizing radiation (probability of causation), and possibilities of interpreting these data so as to match them with conditions in the F.R.G. 3) Results of epidemiological studies with occupationally exposed persons working in nuclear installations or medical establishments, and with population groups living in the environs of nuclear installations. 4) Recent knowledge about radon-induced lung cancer, and recommendations of and measures taken by other countries for reducing radon concentrations in buildings. The summarizing appraisals and recommendations agreed upon by the SSK members upon discussion of the items are given in this publication. (orig./MG) With 31 figs., 41 tabs

  14. Semen quality assessments and their significance in reproductive technology.

    Science.gov (United States)

    Kordan, W; Fraser, L; Wysocki, P; Strzezek, R; Lecewicz, M; Mogielnicka-Brzozowska, M; Dziekońska, A; Soliwoda, D; Koziorowska-Gilun, M

    2013-01-01

    Semen quality assessment methods are very important in predicting the fertilizing ability of persevered spermatozoa and to improve animal reproductive technology. This review discusses some of the current laboratory methods used for semen quality assessments, with references to their relevance in the evaluation of male fertility and semen preservation technologies. Semen quality assessment methods include sperm motility evaluations, analyzed with the computer-assisted semen analysis (CASA) system, and plasma membrane integrity evaluations using fluorescent stains, such as Hoechst 33258 (H33258), SYBR-14, propidium iodide (PI), ethidium homodimer (EthD) and 6-carboxyfluorescein diacetate (CFDA), and biochemical tests, such as the measurement of malondialdehyde (MDA) level. This review addresses the significance of specific fluorochromes and ATP measurements for the evaluation of the sperm mitochondrial status. Laboratory methods used for the evaluation of chromatin status, DNA integrity, and apoptotic changes in spermatozoa have been discussed. Special emphasis has been focused on the application of proteomic techniques, such as two-dimensional (2-D) gel electrophoresis and liquid chromatography mass spectrometry (LC-MS/MS), for the identification of the properties and functions of seminal plasma proteins in order to define their role in the fertilization-related processes. PMID:24597323

  15. Natural And Technological Risk Assessment And Mapping In Russian Federation

    Science.gov (United States)

    Burova, Valentina; Frolova, Nina; Ugarov, Aleksander; Pyrchenko, Vera

    2014-05-01

    Natural and technological disasters are serious threat for residents and infrastructures in urban areas of the Russian Federation and many other countries. Disasters' risk assessment and mapping is the first step to minimize the negative consequences of such events. The paper analyzes different approaches for risk assessment: mathematical simulation and empirical one based on statistic data of past events' consequences. Special attention is paid to verification of vulnerability functions of elements at risk against natural disasters. Numerical modeling of the impact of landslides on the building with various design elements and foundation with CAD systems PLAXIS 3D application was used to identify additional loads on buildings. The results of simulation were taken into account when assessing risk for the Russian Federation territory. The examples of natural and technological risk maps for some regions of the country are given. Verified vulnerability functions of buildings on pier foundation in tabular forms against landslides are presented, as well as verified vulnerability functions for different buildings type against floods.

  16. Thinking Tools in Computer-Based Assessment: Technology Enhancements in Assessments for Learning

    Science.gov (United States)

    Rosen, Yigal

    2014-01-01

    One of the greatest concerns in schools today is how teachers can bring together assessment and learning in a way that is meaningful for students' thinking skills, while focusing on content standards. Better understanding of how different types of technology based thinking tools can be used for improving classroom teaching and learning,…

  17. Reflections on the social epidemiologic dimension of health technology assessment.

    Science.gov (United States)

    Kazanjian, Arminée

    2004-01-01

    Certain key parameters such as safety, efficacy, effectiveness, and cost effectiveness have long been established as key in HTA analysis. Equally important, however, are sociolegal and epidemiologic perspectives. A comprehensive analytic framework will consider the implications of using a technology in the context of societal norms, cultural values, and social institutions and relations. The methodology in which this expanded framework has been developed is termed 'Strategic HTA' to denote its power for the decision-making process. In addition to systematic reviews of published evidence, it incorporates analyses of the influence of dominant social relations on technological development and diffusion. This essay discusses the social epidemiologic aspects of health technology assessment, which includes factors such as sex and gender. It seeks to show how it is possible to bring data from wide-ranging disciplinary perspectives within the parameters of a single scientific inquiry; to draw from them scientifically defensible conclusions; and thereby to realize a deeper understanding of technology impact within a health care system. Armed with such an understanding, policy officials will be better prepared to resolve the competitive clamor of stakeholder voices, and to make the most "equitable" use of the available resources. PMID:15209176

  18. Assessment of pollution prevention and control technology for plating operations

    Science.gov (United States)

    Chalmer, Paul D.; Sonntag, William A.; Cushnie, George C., Jr.

    1995-01-01

    The National Center for Manufacturing Sciences (NCMS) is sponsoring an on-going project to assess pollution prevention and control technology available to the plating industry and to make this information available to those who can benefit from it. Completed project activities include extensive surveys of the plating industry and vendors of technologies and an indepth literature review. The plating industry survey was performed in cooperation with the National Association of Metal Finishers. The contractor that conducted the surveys and prepared the project products was CAI Engineering. The initial products of the project were made available in April, 1994. These products include an extensive report that presents the results of the surveys and literature review and an electronic database. The project results are useful for all those associated with pollution prevention and control in the plating industry. The results show which treatment, recovery and bath maintenance technologies have been most successful for different plating processes and the costs for purchasing and operating these technologies. The project results also cover trends in chemical substitution, the identification of compliance-problem pollutants, sludge generation rates, off-site sludge recovery and disposal options, and many other pertinent topics.

  19. The significance of nuclear ER in the assessment of ER status of breast cancer and ovarian cancer tissues

    International Nuclear Information System (INIS)

    The significance of estrogen receptor in cell nucleus in the assessment of the ER status of patients with breast cancer and ovarian cancer was assessed 151 breast cancer tissues and 124 ovarian cancer tissues were analyzed for their EcR and EnR using radioligand binding assay (RBA). In 36.42% of the breast cancer tissues, both EcR and EnR were positive. This rate was significantly lower than that of tissues with positive EcR alone (55.63%). In the ovarian cancer tissues, the rate of both EcR and EnR position (34.68%) was also significantly lower than that of EcR positive alone (51.61%). Only 65.48% of EcR-positive breast cancer tissues and 67.19% EcR-positive ovarian cancer tissues were accompanied by EnR positive. To assess the ER status of breast cancer or ovarian cancer, it is important to analyse not only EcR but also EnR

  20. Health technology assessment: the contribution of qualitative research.

    Science.gov (United States)

    Leys, Mark

    2003-01-01

    The pragmatism in health care has made health technology assessment (HTA) restrict its scope to a particular set of problems, c.q. methods. The "multidisciplinary and comprehensive nature" of HTA, as the concept is presented in certain definitions, is lacking. Health care is also dominated by a positivistic-rationalistic approach of evaluation. In contrast, social studies of evaluations learn that a major difference has to be made between scientific research on (potential) impact of a technology and valuing these effects. In this contribution, we will discuss how the positivistic scientific bias of current HTA practice can be made up with other research traditions. More specifically, we focus on the question of how social scientists and particularly how qualitative research can contribute to HTA, complementary to positivistic studies of evidence and efficacy. PMID:12862189