WorldWideScience

Sample records for cancer final technology assessment

  1. Liquefaction technology assessment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1979-05-01

    A survey of coal liquefaction technology and analysis of projected relative performance of high potential candidates has been completed and the results are reported here. The key objectives of the study included preparation of a broad survey of the status of liquefaction processes under development, selection of a limited number of high potential process candidates for further study, and an analysis of the relative commercial potential of these candidates. Procedures which contributed to the achievement of the above key goals included definition of the characteristics and development status of known major liquefaction process candidates, development of standardized procedures for assessing technical, environmental, economic and product characteristics for the separate candidates, and development of procedures for selecting and comparing high potential processes. The comparisons were made for three production areas and four marketing areas of the US. In view of the broad scope of the objectives the survey was a limited effort. It used the experience gained during preparation of seven comprehensive conceptual designs/economic evaluations plus comprehensive reviews of the designs, construction and operation of several pilot plants. Results and conclusions must be viewed in the perspective of the information available, how this information was treated, and the full context of the economic comparison results. Comparative economics are presented as ratios; they are not intended to be predictors of absolute values. Because the true cost of constructing and operating large coal conversion facilities will be known only after commercialization, relative values are considered more appropriate. (LTN)

  2. Zero-emission vehicle technology assessment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Woods, T.

    1995-08-01

    This is the final report in the Zero-Emission Vehicle (ZEV) Technology Assessment, performed for NYSERDA by Booz-Allen & Hamilton Inc. Booz-Allen wrote the final report, and performed the following tasks as part of the assessment: assembled a database of key ZEV organizations, their products or services, and plans; described the current state of ZEV technologies; identified barriers to widespread ZEV deployment and projected future ZEV technical capabilities; and estimated the cost of ZEVs from 1998 to 2004. Data for the ZEV Technology Assessment were obtained from several sources, including the following: existing ZEV industry publications and Booz-Allen files; major automotive original equipment manufacturers; independent electric vehicle manufacturers; battery developers and manufacturers; infrastructure and component developers and manufacturers; the U.S. Department of Energy, the California Air Resources Board, and other concerned government agencies; trade associations such as the Electric Power Research Institute and the Electric Transportation Coalition; and public and private consortia. These sources were contacted by phone, mail, or in person. Some site visits of manufacturers also were conducted. Where possible, raw data were analyzed by Booz-Allen staff and/or verified by independent sources. Performance data from standardized test cycles were used as much as possible.

  3. Final Environmental Assessment for Hypersonic Technology Vehicle 2 Flight Tests

    Science.gov (United States)

    2009-04-28

    Up to four lithium ion and lithium thionyl chloride batteries , each weighing between 1 and 40 lb (0.5 and 18.5 kg) Propulsion Approximately 3 lb...Record HCl Hydrogen Chloride HTV Hypersonic Technology Vehicle ICBM Intercontinental Ballistic Missile INRMP Integrated Natural Resources Management...dual flight termination receivers, radar transponder, batteries , and harnesses. Onboard transmitter (radio frequency) power output varies from 10 to

  4. Assessment of the magnesium primary production technology. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Flemings, M.C.; Kenney, G.B.; Sadoway, D.R.; Clark, J.P.; Szekely, J.

    1981-02-01

    At current production levels, direct energy savings achievable in primary magnesium production are 1.2 milliquads of energy per annum. Were magnesium to penetrate the automotive market to an average level of 50 pounds per vehicle, the resultant energy savings at the production stage would be somewhat larger, but the resulting savings in gasoline would conserve an estimated 325 milliquads of energy per year. The principal barrier to more widespread use of magnesium in the immediate future is its price. A price reduction of magnesium of 10% would lead to widespread conversion of aluminum die and permanent mold castings to magnesium. This report addresses the technology of electrolytic and thermic magnesium production and the economics of expanded magnesium production and use.

  5. Assessment of control technology for stationary sources. Volume II: control technology data tables. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Minicucci, D.; Herther, M.; Babb, L.; Kuby, W.

    1980-02-01

    This report, the Control Technology Data Tables, is the second volume of the three-volume final report for the contract. It presents in tabular format, qualitative descriptions of control options for the various sources and quantitative information on control technology cost, efficiency, reliability, energy consumption, other environmental impacts and application status. Also included is a code list which classifies the stationary sources examined by industry, process, and emission source.

  6. Constructive technology assessment of gene expression profiling for breast cancer

    NARCIS (Netherlands)

    Retèl, Valesca Pavlawna

    2011-01-01

    Constructive Technology Assessment (CTA) can be used as a complementary approach to Health Technology Assessment (HTA), especially for the early and dynamic introduction of new technologies in a controlled way. CTA is based on the idea that during the course of technology development, choices are co

  7. Oral cancer: molecular technologies for risk assessment and diagnosis

    Institute of Scientific and Technical Information of China (English)

    Wan Tao Chen

    2008-01-01

    @@ Purpose: The effective biomarkers related to diagnosis, metastasis, drug resistance and irradiation sensitivity of oral cancers will help the pathologist and oncologist to determine the molecular taxonomy diagnosis and design the individualization treatment for the patients with oral cancers.

  8. Review and assessments of potential environmental, health and safety impacts of MHD technology. Final draft

    Energy Technology Data Exchange (ETDEWEB)

    1978-01-01

    The purpose of this document is to develop an environmental, health and safety (EH and S) assessment and begin a site - specific assessment of these and socio - economic impacts for the magnetohydrodynamics program of the United States Department of Energy. This assessment includes detailed scientific and technical information on the specific EH and S issues mentioned in the MHD Environmental Development Plan. A review of current literature on impact-related subjects is also included. This document addresses the coal-fired, open-cycle MHD technology and reviews and assesses potential EH and S impacts resulting from operation of commercially-installed technology.

  9. Technology assessment for the advanced life detector. Final technical report, May 1987-January 1988

    Energy Technology Data Exchange (ETDEWEB)

    Burrows, W.D.; George, D.T.

    1988-01-29

    This report summarizes an assessment of technology available to develop a noninvasive life detector for use on the battlefield. The detectors determine if casualties wearing chemical protective overgarments are alive or dead without further exposing either the casualties or the aidmen to the contaminated environment. Seven technology approaches sponsored by the Department of Defense (comprising 11 devices), four technologies identified in a market survey, and one device described in a Broad Agency Announcement proposal were examined as candidate Advanced Life Detectors. The technologies and instruments surveyed included three transmitter-receiver technologies, an electrocardiogram (ECG) technology, pacemaker-transmitter/receiver, dry electrode heart rate monitor, five microwave technologies, flash reflectance oximetry, an ultrasound technology, a streaming potential technology, a dry electrode ECG monitor coupled to a microphone, a statometric technique for determining heart rate and blood pressure, and a vital-signs monitor that determines heart rate and blood pressure using blood pressure cuff and microphones incorporated into the cuff. Analysis of the state-of-the-art of each device indicates that none of them are advanced enough to fulfill all the requirements of the draft Joint Services Operational Requirement. Three of the devices identified are recommended for further evaluation.

  10. Geolocation Technologies Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Magnoli, D E

    2003-06-02

    This paper is the final report for LL998 In Situ Sensing Subtask 7 (Geo-location) undertaken for NNSA NA-22 enabling technologies R&D for Counterproliferation Detection. A few state-of-the-art resolution parameters are presented for accelerometers, indoor and outdoor GPS (Global Positioning Satellite) systems, and INSs (Inertial Navigation Systems). New technologies are described, including one which has demonstrated the ability to track within a building to a resolution of under a foot.

  11. Trialling computer touch-screen technology to assess psychological distress in patients with gynaecological cancer

    Directory of Open Access Journals (Sweden)

    Georgia Halkett

    2010-12-01

    Full Text Available BackgroundCancer impacts on the psychological well-being of many cancer patients. Appropriate tools can be used to assist health professionals in identifying patient needs and psychological distress. Recent research suggests that touchscreen technology can be used to administer surveys. The aim of this study was to evaluate the use of a touchscreen system in comparison to written questionnaires in a large tertiary hospital in Western Australia (WA.Method Patients who were scheduled to commence treatment for gynaecological cancer participated in this study. Patients were assigned to complete either a written questionnaire or the same survey using the touchscreen technology. Both methods of survey contained the same scales. All participants were asked to complete a follow-up patient satisfaction survey. Semi-structured interviews were conducted with health professionals to elicit views about the implementation of the technology and the available referral pathways. Data was analysed using descriptive statistics and content analysis. ResultsThirty patients completed the touchscreen questionnaires and an equal number completed the survey on paper. Participants who used the touchscreens were not significantly more satisfied than other participants. Four themes were noted in the interviews with health professionals: usability of technology, patients’ acceptance of technology, advantages of psychological screening and the value of the instruments included.ConclusionAlthough previous studies report that computerised assessments are a feasible option for assessing cancer patients’ needs, the data collected in this study demonstrates that the technology was not reliable with significant practical problems. The technology did not serve these patients better than pen and paper.

  12. Assessment of control technology for stationary sources. Volume I: technical discussion. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Minicucci, D.; Herther, M.; Babb, L.; Kuby, W.

    1980-02-01

    The purpose of this project was to develop a reference document for use by the Air Resources Board, local air pollution control districts, and the U.S. Environmental Protection Agency that describes technological options available for the control of emissions from stationary sources located in California. Control technologies were examined for 10 industry groups and six air pollutants. Volume I, Technical Discussion, includes an overall introduction to the project, descriptions of its major elements, background information for each industry group addressed, and the project bibliography. In Volume II, Control Technology Data Tables, qualitative descriptions of control options for the various sources and quantitative information on control technology cost, efficiency, reliability, energy consumption, other environmental impacts, and application status are presented in tabular format. Also included is a code list that classifies the stationary sources examined by industry, process and emission source.

  13. Assessment of computer dispatch technology in the Paratransit Industry. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Stone, J.R.; Gilbert, G.; Nalevanko, A.

    1992-03-01

    The document explores how computer dispatch technology can improve the efficiency of dispatching shared-ride vehicles on a real time basis. The document investigates the current operating capabilities of such systems, their costs and economic benefits, their suitability for specific transit applications, and future technological directions for computer dispatch. The study found such systems were not inexpensive, averaging about $1 million for a company with 300 taxis. However, requirements of the Americans with Disabilities Act were expected to increase the demand for such applications. The current focus of the industry is on technology and a variety of hardware and software improvements: smart cards, automatic vehicle location, real-time scheduling for shared rides, integrated reporting and billing, and graphic displays of service areas with relative passenger and vehicle locations.

  14. An Assessment of the Status of Captive Broodstock Technology of Pacific Salmon, 1995 Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Flagg, Thomas A.; Mahnaken, Conrad V.W.; Hard, Jeffrey J.

    1995-06-01

    This report provides guidance for the refinement and use of captive broodstock technology for Pacific salmon (Oncorhynchus spp.) by bringing together information on the husbandry techniques, genetic risks, physiology, nutrition, and pathology affecting captive broodstocks. Captive broodstock rearing of Pacific salmon is an evolving technology, as yet without well defined standards. At present, we regard captive rearing of Pacific salmon as problematic: high mortality rates and low egg viability were common in the programs we reviewed for this report. One of the most important elements in fish husbandry is the culture environment itself. Many captive broodstock programs for Pacific salmon have reared fish from smolt-to-adult in seawater net-pens, and most have shown success in providing gametes for recovery efforts. However, some programs have lost entire brood years to diseases that transmitted rapidly in this medium. Current programs for endangered species of Pacific salmon rear most fish full-term to maturity in fresh well-water, since ground water is low in pathogens and thus helps ensure survival to adulthood. Our review suggested that captive rearing of fish in either freshwater, well-water, or filtered and sterilized seawater supplied to land-based tanks should produce higher survival than culture in seawater net-pens.

  15. Environmental Assessment For Cleanup and Closure of the Energy Technology Engineering Center. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2003-03-01

    DOE analyzed two cleanup and closure alternatives and the No Action Alternative, in accordance with the Council on Environmental Quality regulations implementing NEPA (40 CFR Parts 1500-1508) and DOE's NEPA implementing regulations (10 CFR Part 1021). Under Alternative 1, DOE is proposing to clean up the remaining ETEC facilities using the existing site specific cleanup standard of 15 mrem/yr. (plus DOE's As Low As Reasonably Achievable--ALARA-principle) for decontamination of radiological facilities and surrounding soils (Alternative 1). An annual 15-millirem additional radiation dose to the maximally exposed individual (assumed to be an individual living in a residential setting on Area IV) from all exposure pathways (air, soil, groundwater) equates to an additional theoretical lifetime cancer risk of no more than 3 x 10-4 (3 in 10,000). For perspective, it is estimated that the average individual in the United States receives a dose of about 300 millirem each year from natural sources of radiation. However, actual exposures generally will be much lower as a result of the application of the ''as low as reasonably achievable'' (ALARA) principle. Based on post-remediation verification sampling previous cleanups have generally resulted in a 2 x 10-6 level of residual risk. DOE would decontaminate, decommission, and demolish the remaining radiological facilities. DOE would also decommission and demolish the one remaining sodium facility and all of the remaining uncontaminated support buildings for which it is responsible. The ongoing RCRA corrective action program, including groundwater treatment (interim measures), would continue. Other environmental impacts would include 2.5 x 10-3 fatalities as a result of LLW shipments and 6.0 x 10-3 fatalities as a result of emission exhaust from all shipments. DOE would also decommission and demolish the remaining sodium facility and decommission and

  16. Environmental Assessment For Cleanup and Closure of the Energy Technology Engineering Center. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2003-03-01

    DOE analyzed two cleanup and closure alternatives and the No Action Alternative, in accordance with the Council on Environmental Quality regulations implementing NEPA (40 CFR Parts 1500-1508) and DOE's NEPA implementing regulations (10 CFR Part 1021). Under Alternative 1, DOE is proposing to clean up the remaining ETEC facilities using the existing site specific cleanup standard of 15 mrem/yr. (plus DOE's As Low As Reasonably Achievable--ALARA-principle) for decontamination of radiological facilities and surrounding soils (Alternative 1). An annual 15-millirem additional radiation dose to the maximally exposed individual (assumed to be an individual living in a residential setting on Area IV) from all exposure pathways (air, soil, groundwater) equates to an additional theoretical lifetime cancer risk of no more than 3 x 10-4 (3 in 10,000). For perspective, it is estimated that the average individual in the United States receives a dose of about 300 millirem each year from natural sources of radiation. However, actual exposures generally will be much lower as a result of the application of the ''as low as reasonably achievable'' (ALARA) principle. Based on post-remediation verification sampling previous cleanups have generally resulted in a 2 x 10-6 level of residual risk. DOE would decontaminate, decommission, and demolish the remaining radiological facilities. DOE would also decommission and demolish the one remaining sodium facility and all of the remaining uncontaminated support buildings for which it is responsible. The ongoing RCRA corrective action program, including groundwater treatment (interim measures), would continue. Other environmental impacts would include 2.5 x 10-3 fatalities as a result of LLW shipments and 6.0 x 10-3 fatalities as a result of emission exhaust from all shipments. DOE would also decommission and demolish the remaining sodium facility and decommission and

  17. Assessment of technologies for hazardous waste site remediation: Non-treatment technologies and pilot scale facility implementation -- excavation -- storage technology -- safety analysis and review statement. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, H.R.; Overbey, W.K. Jr.; Koperna, G.J. Jr.

    1994-02-01

    The purpose of this study is to assess the state-of-the-art of excavation technology as related to environmental remediation applications. A further purpose is to determine which of the excavation technologies reviewed could be used by the US Corp of Engineers in remediating contaminated soil to be excavated in the near future for construction of a new Lock and Dam at Winfield, WV. The study is designed to identify excavation methodologies and equipment which can be used at any environmental remediation site but more specifically at the Winfield site on the Kanawha River in Putnam County, West Virginia. A technical approach was determined whereby a functional analysis was prepared to determine the functions to be conducted during the excavation phase of the remediation operations. A number of excavation technologies were identified from the literature. A set of screening criteria was developed that would examine the utility and ranking of the technologies with respect to the operations that needed to be conducted at the Winfield site. These criteria were performance, reliability, implementability, environmental safety, public health, and legal and regulatory compliance. The Loose Bulk excavation technology was ranked as the best technology applicable to the Winfield site. The literature was also examined to determine the success of various methods of controlling fugitive dust. Depending upon any changes in the results of chemical analyses, or prior remediation of the VOCs from the vadose zone, consideration should be given to testing a new ``Pneumatic Excavator`` which removes the VOCs liberated during the excavation process as they outgas from the soil. This equipment however would not be needed on locations with low levels of VOC emissions.

  18. Establishment of a bioassay system for cancer risk assessment in energy technology

    Energy Technology Data Exchange (ETDEWEB)

    Ts' o, P.O.P.; Bruce, S.A.; Brown, A. (eds.)

    1983-09-01

    Separate abstracts were prepared for 20 papers in this report. For several years the Department of Energy (DOE), Office of Health and Environmental Research (OHER), has supported a research program aimed at developing new experimental approaches for the improvement of cancer risk assessments. The central issue is to overcome the organizational, species and other barriers that make it difficult to extrapolate laboratory-based data to predict risk to man. Most of the participants at the meeting are involved in research aimed at understanding the mechanism(s) of chemical carcinogenesis. Complex mixtures of chemicals are associated with many energy technologies. DOE's initial program emphasis focused on semi-applied research aimed at quantitative evaluation of carcinogenic activity of complex materials. Since much progress has been made in DOE integrated technology-specific chemical-biological characterization studies, the number and kinds of chemicals of concern has been reduced to a relatively few well-defined classes. Although the classes of compounds seem to be unique to some of the synfuel technologies, they are quite similar to compounds of general interest, for example, poly-nuclear aromatic hydrocarbons. Special emphasis was placed on molecular and cellular dosimetry as one of the key requirements for quantitative comparison of effects at the cell level in vivo and in vitro. Although it is relatively easy to measure cell, tissue, organ and whole organism doses associated with radiation exposures, we are just learning how to do this for chemical agents. Several methods have been developed in the past several years which can be used.

  19. (Very) Early technology assessment and translation of predictive biomarkers in breast cancer.

    Science.gov (United States)

    Miquel-Cases, Anna; Schouten, Philip C; Steuten, Lotte M G; Retèl, Valesca P; Linn, Sabine C; van Harten, Wim H

    2017-01-01

    Predictive biomarkers can guide treatment decisions in breast cancer. Many studies are undertaken to discover and translate these biomarkers, yet few biomarkers make it to practice. Before use in clinical decision making, predictive biomarkers need to demonstrate analytical validity, clinical validity and clinical utility. While attaining analytical and clinical validity is relatively straightforward, by following methodological recommendations, the achievement of clinical utility is extremely challenging. It requires demonstrating three associations: the biomarker with the outcome (prognostic association), the effect of treatment independent of the biomarker, and the differential treatment effect between the prognostic and the predictive biomarker (predictive association). In addition, economical, ethical, regulatory, organizational and patient/doctor-related aspects are hampering the translational process. Traditionally, these aspects do not receive much attention until formal approval or reimbursement of a biomarker test (informed by Health Technology Assessment (HTA)) is at stake, at which point the clinical utility and sometimes price of the test can hardly be influenced anymore. When HTA analyses are performed earlier, during biomarker research and development, they may prevent further development of those biomarkers unlikely to ever provide sufficient added value to society, and rather facilitate translation of the promising ones. Early HTA is particularly relevant for the predictive biomarker field, as expensive medicines are under pressure and the need for biomarkers to guide their appropriate use is huge. Closer interaction between clinical researchers and HTA experts throughout the translational research process will ensure that available data and methodologies will be used most efficiently to facilitate biomarker translation.

  20. Solar/hydrogen systems technologies. Volume II (Part 2 of 2). Solar/hydrogen systems assessment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Escher, W. J.D.; Foster, R. W.; Tison, R. R.; Hanson, J. A.

    1980-06-02

    Volume II of the Solar/Hydrogen Systems Assessment contract report (2 volumes) is basically a technological source book. Relying heavily on expert contributions, it comprehensively reviews constituent technologies from which can be assembled a wide range of specific solar/hydrogen systems. Covered here are both direct and indirect solar energy conversion technologies; respectively, those that utilize solar radiant energy input directly and immediately, and those that absorb energy from a physical intermediary, previously energized by the sun. Solar-operated hydrogen energy production technologies are also covered in the report. The single most prominent of these is water electrolysis. Utilization of solar-produced hydrogen is outside the scope of the volume. However, the important hydrogen delivery step is treated under the delivery sub-steps of hydrogen transmission, distribution and storage. An exemplary use of the presented information is in the synthesis and analysis of those solar/hydrogen system candidates documented in the report's Volume I. Moreover, it is intended that broad use be made of this technology information in the implementation of future solar/hydrogen systems. Such systems, configured on either a distributed or a central-plant basis, or both, may well be a major significance in effecting an ultimate transition to renewable energy systems.

  1. Solar/hydrogen systems technologies. Volume II (Part 1 of 2). Solar/hydrogen systems assessment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Escher, W. J.D.; Foster, R. W.; Tison, R. R.; Hanson, J. A.

    1980-06-02

    Volume II of the Solar/Hydrogen Systems Assessment contract report (2 volumes) is basically a technological source book. Relying heavily on expert contributions, it comprehensively reviews constituent technologies from which can be assembled a wide range of specific solar/hydrogen systems. Covered here are both direct and indirect solar energy conversion technologies; respectively, those that utilize solar radiant energy input directly and immediately, and those that absorb energy from a physical intermediary, previously energized by the sun. Solar-operated hydrogen energy production technologies are also covered in the report. The single most prominent of these is water electrolysis. Utilization of solar-produced hydrogen is outside the scope of the volume. However, the important hydrogen delivery step is treated under the delivery sub-steps of hydrogen transmission, distribution and storage. An exemplary use of the presented information is in the synthesis and analysis of those solar/hydrogen system candidates documented in the report's Volume I. Morever, it is intended that broad use be made of this technology information in the implementation of future solar/hydrogen systems. Such systems, configured on either a distributed or a central-plant basis, or both, may well be of major significance in effecting an ultimate transition to renewable energy systems.

  2. Subcontract Report: Final Report on Assessment of Motor Technologies for Traction Drives of Hybrid and Electric Vehicles (Subcontract #4000080341)

    Energy Technology Data Exchange (ETDEWEB)

    Fezzler, Raymond [BIZTEK Consulting, Inc.

    2011-03-01

    Currently, interior permanent magnet (IPM) motors with rare-earth (RE) magnets are almost universally used for hybrid and electric vehicles (EVs) because of their superior properties, particularly power density. However, there is now a distinct possibility of limited supply or very high cost of RE magnets that could make IPM motors unavailable or too expensive. Because development of electric motors is a critical part of the U.S. Department of Energy (DOE) Advanced Power Electronics and Motors activity, DOE needs to determine which options should be investigated and what barriers should be addressed. Therefore, in order to provide a basis for deciding which research topics should be pursued, an assessment of various motor technologies was conducted to determine which, if any, is potentially capable of meeting FreedomCAR 2015 and 2020 targets. Highest priority was given to IPM, surface mounted permanent magnet (SPM), induction, and switched reluctance (SR) motors. Also of interest, but with lesser emphasis, were wheel motors, multiple-rotor motors, motors with external excitation, and several others that emerged from the assessment. Cost and power density (from a design perspective, the power density criterion translates to torque density) are emerging as the two most important properties of motors for traction drives in hybrid and EVs, although efficiency and specific power also are very important. The primary approach for this assessment involved interviews with original equipment manufacturers (OEMs), their suppliers, and other technical experts. For each technology, the following issues were discussed: (1) The current state-of-the-art performance and cost; (2) Recent trends in the technology; (3) Inherent characteristics of the motor - which ones limit the ability of the technology to meet the targets and which ones aid in meeting the target; (4) What research and development (R&D) would be needed to meet the targets; and (5) The potential for the technology to

  3. Multi-fuel reformers for fuel cells used in transportation: Assessment of hydrogen storage technologies. Phase 2: Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-05-01

    During Phase 1 of this program, the authors evaluated all known hydrogen storage technologies (including those that are now practiced and those that are development) in the context of fuel cell vehicles. They determined that among the development technologies, carbon sorbents could most benefit from closer scrutiny. During Phase 2 of this program, they tested ten different carbon sorbents at various practical temperatures and pressures, and developed the concept of the usable Capacity Ratio, which is the ratio of the mass of hydrogen that can be released from a carbon-filled tank to the mass of hydrogen that can be released from an empty tank. The authors also commissioned the design, fabrication, and NGV2 (Natural Gas Vehicle) testing of an aluminum-lined, carbon-composite, full-wrapped pressure vessel to store hydrogen at 78 K and 3,000 psi. They constructed a facility to pressure cycle the tank at 78 K and to temperature cycle the tank at 3,000 psi, tested one such tank, and submitted it for a burst test. Finally, they devised a means by which cryogenic compressed hydrogen gas tanks can be filled and discharged using standard hardware--that is, without using filters, valves, or pressure regulators that must operate at both low temperature and high pressure. This report describes test methods and test results of carbon sorbents and the design of tanks for cold storage. 7 refs., 91 figs., 10 tabs.

  4. Assessing Technologies for Information-Seeking on Prostate Cancer Screening by Low-Income Men

    Directory of Open Access Journals (Sweden)

    Susan W. McRoy

    2014-11-01

    Full Text Available Purpose: This paper presents a multipart investigation of the benefits and challenges in deploying automated question-answering as an alternative to web-based searching to provide information about prostate cancer screening for low-income men age 40 years and older. Methods: The study comprised: 1 a survey assessing current use of the Internet, mobile phones and texting; 2 a controlled observational study of both web-based searching and automated question-answering for information about prostate cancer; and 3 a formative field study in which subjects interacted with a health department nurse using text messages. Results: Survey results suggest the target population has greater access to, and familiarity with, cell phones and text messaging compared to the Internet and web-based searching. Participants were significantly more confident using a cell phone and preferred to get health information through text messaging. Participants in the controlled observational study accepted the text messaging system, with most indicating it answered their questions, was easy to use and was a favorable tool for information-seeking. The field study also demonstrated potential for automated question-answering and text messaging to help the target population access health information. Conclusions: A two-way text messaging system has great potential to promote health communication and health information distribution. Participant interest in this system was high and did not seem to be specific to prostate cancer screening, suggesting that information about other topics, such as high blood pressure screening, could be provided similarly. We believe more investigations should be focused on this area, especially on benefits for the low-income community.

  5. Assessment of the potential for refinery applications of inorganic membrane technology: An identification and screening analysis. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, H.E.; Schulman, B.L.

    1993-05-01

    Commercial application of membrane technology in the separation of gas, liquid, and solid streams has grown to a business with worldwide revenues exceeding $1 billion annually. Use of organic membranes for industrial gas separation, particularly in the refining industry, is one of the major growth areas. However, organic membranes based on polymeric separation barriers, are susceptible to damage by liquids, and careful precautions must be taken to retain the system integrity. Researchers are currently developing small pore sized inorganic membranes which may substantially increase the efficiency and economics in selected refinery separation applications. Expected advantages of these advanced inorganic membranes include high permeability, high selectivity, and low manufacturing cost. SFA Pacific conducted a screening analysis to identify applications for inorganic membrane technology in the petroleum refining industry and their potential cost advantages over competing separation systems. Two meetings were held in connection with this project. Copies of Viewgraphs presented by SFA Pacific at these meetings are attached in Appendices A and C. Potential high priority applications and market impacts of advanced inorganic membrane technology in the refining industry are addressed in this report, and include the following areas: Competitive separation technologies; application of those technologies; incentives for inorganic membranes; market benefits and impacts of inorganic membranes.

  6. Advocacy and technology assessment

    Science.gov (United States)

    Jones, E. M.

    1975-01-01

    A highly structured treatment is presented of adversarial systems as they apply to technology assessment. One approach to the problem of adequate criteria of assessment focuses upon the internal operations of assessment entities; operations include problem perception, problem formulation, selection, utilization, determination, and evaluation. Potential contributions of advocacy as a mode of inquiry in technology are discussed; advocacy is evaluated by representative sets of criteria of adequate assessment which include participant criteria, perspectives criteria, situations criteria, base values criteria, and strategies criteria.

  7. Product technology and market assessment for silicon carbide whisker reinforced alumina heat-exchanger tubes. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Loutfy, R.O.; Withers, J.C. [Materials and Electrochemical Research Corp., Tucson, AZ (United States); Chakravarti, D. [Arizona Univ., Tucson, AZ (United States)

    1993-10-01

    This report describes a study designed to develop an assessment of key performance features, desirable technical specifications and market potential for silicon carbide whisker-reinforced alumina (henceforth SCWRA) tubes for heat exchanger applications in a number of industries. The results of the first stage of a Delphi study conducted in the US market are presented. The second phase of the study is in progress. The first stage results suggest that there is a small market for SCWRA tubes in heat exchanger applications. The market is expected to grow steadily during the 1990`s. With appropriate performance specifications and competitive pricing, growth should come from (a) new applications that permit recovery in cases that were previously infeasible and (b) selective, partial substitution and replacement of current ceramics and metal/ceramic composites in existing applications. We identify key performance factors and detailed specifications needed in six designated industries (primary metals, fabricated metals, chemicals, glass, utility and incinerators). Reliability, durability and low maintenance costs emerge as critical performance factors across these industries. The data show that although ceramics are recognized as having better properties, enhancing reliability and durability and thus improving maintenance cost performance is a key priority. Such improvements, reflected in the objectives for SCWRA tubes, should facilitate adoption in both new and existing applications. At this time, we are unable to assess market size directly. However, expert judgment provided indices tracking the projected market for heat exchanger tubes from 1990 to 2005.

  8. Exploiting rod technology. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-06-01

    ROD development was proceeding apace until recent budgetary decisions caused funding support for ROD development to be drastically reduced. The funding which was originally provided by DARPA and the Balanced Technology Initiative (BTI) Office has been cut back to zero from $800K. To determine the aeroballistic coefficients of a candidate dart, ARDEC is currently supporting development out of its own 6.2 funds at about $100K. ARDEC has made slow progress toward achieving this end because of failures in the original dart during testing. It appears that the next dart design to be tested will diverge from the original concept visualized by DARPA and Science and Technology Associates (STA). STA, the design engineer, takes exception to these changes on the basis of inappropriate test conditions and insufficient testing. At this time, the full resolution of this issue will be difficult because of the current management structure, which separates the developer (ARDEC) from the designer (STA).

  9. Information technology resources assessment

    Energy Technology Data Exchange (ETDEWEB)

    Stevens, D.F. (ed.)

    1992-01-01

    This year's Information Technology Resources Assessment (ITRA) is something of a departure from traditional practice. Past assessments have concentrated on developments in fundamental technology, particularly with respect to hardware. They form an impressive chronicle of decreasing cycle times, increasing densities, decreasing costs (or, equivalently, increasing capacity and capability per dollar spent), and new system architectures, with a leavening of operating systems and languages. Past assessments have aimed -- and succeeded -- at putting information technology squarely in the spotlight; by contrast, in the first part of this assessment, we would like to move it to the background, and encourage the reader to reflect less on the continuing technological miracles of miniaturization in space and time and more on the second- and third-order implications of some possible workplace applications of these miracles. This Information Technology Resources Assessment is intended to provide a sense of technological direction for planners in projecting the hardware, software, and human resources necessary to support the diverse IT requirements of the various components of the DOE community. It is also intended to provide a sense of our new understanding of the place of IT in our organizations.

  10. Information technology resources assessment

    Energy Technology Data Exchange (ETDEWEB)

    Stevens, D.F. [ed.

    1992-01-01

    This year`s Information Technology Resources Assessment (ITRA) is something of a departure from traditional practice. Past assessments have concentrated on developments in fundamental technology, particularly with respect to hardware. They form an impressive chronicle of decreasing cycle times, increasing densities, decreasing costs (or, equivalently, increasing capacity and capability per dollar spent), and new system architectures, with a leavening of operating systems and languages. Past assessments have aimed -- and succeeded -- at putting information technology squarely in the spotlight; by contrast, in the first part of this assessment, we would like to move it to the background, and encourage the reader to reflect less on the continuing technological miracles of miniaturization in space and time and more on the second- and third-order implications of some possible workplace applications of these miracles. This Information Technology Resources Assessment is intended to provide a sense of technological direction for planners in projecting the hardware, software, and human resources necessary to support the diverse IT requirements of the various components of the DOE community. It is also intended to provide a sense of our new understanding of the place of IT in our organizations.

  11. Information Technology Resources Assessment

    Energy Technology Data Exchange (ETDEWEB)

    1993-04-01

    The Information Technology Resources Assessment (ITRA) is being published as a companion document to the Department of Energy (DOE) FY 1994--FY 1998 Information Resources Management Long-Range Plan. This document represents a collaborative effort between the Office of Information Resources Management and the Office of Energy Research that was undertaken to achieve, in part, the Technology Strategic Objective of IRM Vision 21. An integral part of this objective, technology forecasting provides an understanding of the information technology horizon and presents a perspective and focus on technologies of particular interest to DOE program activities. Specifically, this document provides site planners with an overview of the status and use of new information technology for their planning consideration.

  12. Nuclear Nonproliferation Ontology Assessment Team Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Strasburg, Jana D.; Hohimer, Ryan E.

    2012-01-01

    Final Report for the NA22 Simulations, Algorithm and Modeling (SAM) Ontology Assessment Team's efforts from FY09-FY11. The Ontology Assessment Team began in May 2009 and concluded in September 2011. During this two-year time frame, the Ontology Assessment team had two objectives: (1) Assessing the utility of knowledge representation and semantic technologies for addressing nuclear nonproliferation challenges; and (2) Developing ontological support tools that would provide a framework for integrating across the Simulation, Algorithm and Modeling (SAM) program. The SAM Program was going through a large assessment and strategic planning effort during this time and as a result, the relative importance of these two objectives changed, altering the focus of the Ontology Assessment Team. In the end, the team conducted an assessment of the state of art, created an annotated bibliography, and developed a series of ontological support tools, demonstrations and presentations. A total of more than 35 individuals from 12 different research institutions participated in the Ontology Assessment Team. These included subject matter experts in several nuclear nonproliferation-related domains as well as experts in semantic technologies. Despite the diverse backgrounds and perspectives, the Ontology Assessment team functioned very well together and aspects could serve as a model for future inter-laboratory collaborations and working groups. While the team encountered several challenges and learned many lessons along the way, the Ontology Assessment effort was ultimately a success that led to several multi-lab research projects and opened up a new area of scientific exploration within the Office of Nuclear Nonproliferation and Verification.

  13. [Health technology assessment report. Use of liquid-based cytology for cervical cancer precursors screening].

    Science.gov (United States)

    Ronco, Guglielmo; Confortini, Massimo; Maccallini, Vincenzo; Naldoni, Carlo; Segnan, Nereo; Sideri, Mario; Zappa, Marco; Zorzi, Manuel; Calvia, Maria; Giorgi Rossi, Paolo

    2012-01-01

    OBJECTIVE OF THE PROJECT: Purpose of this Report is to evaluate the impact of the introduction of liquid-based cytology (LBC) in cervical cancer screening in terms of efficacy, undesired effects, costs and implications for organisation. EFFICACY AND UNDESIRED EFFECTS: LBC WITH MANUAL INTERPRETATION: The estimates of cross-sectional accuracy for high-grade intraepithelial neoplasia (CIN2 or more severe and CIN3 or more severe) obtained by a systematic review and meta-analysis published in 2008 were used. This review considered only studies in which all women underwent colposcopy or randomised controlled trials (RCTs) with complete verification of test positives. A systematic search of RCTs published thereafter was performed. Three RCTs were identified. One of these studies was conducted in 6 Italian regions and was of large size (45,174 women randomised); a second one was conducted in another Italian region (Abruzzo) and was of smaller size (8,654 women randomised); a third RCT was conducted in the Netherlands and was of large size (89,784 women randomised). No longitudinal study was available. There is currently no clear evidence that LBC increases the sensitivity of cytology and even less that its introduction increases the efficacy of cervical screening in preventing invasive cancers. The Italian randomised study NTCC showed a decrease in specificity, which was not observed in the other two RCTs available. In addition, the 2008 meta-analysis observed a reduction - even if minimal - in specificity just at the ASC-US cytological cut-off, but also a remarkable heterogeneity between studies. These results suggest that the effect of LBC on specificity is variable and plausibly related to the local style of cytology interpretation. There is evidence that LBC reduces the proportion of unsatisfactory slides, although the size of this effect varies remarkably. LBC WITH COMPUTER-ASSISTED INTERPRETATION: An Australian study, based on double testing, showed a statistically

  14. The first step in the development of text mining technology for cancer risk assessment: identifying and organizing scientific evidence in risk assessment literature

    Directory of Open Access Journals (Sweden)

    Sun Lin

    2009-09-01

    Full Text Available Abstract Background One of the most neglected areas of biomedical Text Mining (TM is the development of systems based on carefully assessed user needs. We have recently investigated the user needs of an important task yet to be tackled by TM -- Cancer Risk Assessment (CRA. Here we take the first step towards the development of TM technology for the task: identifying and organizing the scientific evidence required for CRA in a taxonomy which is capable of supporting extensive data gathering from biomedical literature. Results The taxonomy is based on expert annotation of 1297 abstracts downloaded from relevant PubMed journals. It classifies 1742 unique keywords found in the corpus to 48 classes which specify core evidence required for CRA. We report promising results with inter-annotator agreement tests and automatic classification of PubMed abstracts to taxonomy classes. A simple user test is also reported in a near real-world CRA scenario which demonstrates along with other evaluation that the resources we have built are well-defined, accurate, and applicable in practice. Conclusion We present our annotation guidelines and a tool which we have designed for expert annotation of PubMed abstracts. A corpus annotated for keywords and document relevance is also presented, along with the taxonomy which organizes the keywords into classes defining core evidence for CRA. As demonstrated by the evaluation, the materials we have constructed provide a good basis for classification of CRA literature along multiple dimensions. They can support current manual CRA as well as facilitate the development of an approach based on TM. We discuss extending the taxonomy further via manual and machine learning approaches and the subsequent steps required to develop TM technology for the needs of CRA.

  15. Technologies for Language Assessment.

    Science.gov (United States)

    Burstein, Jill; And Others

    1996-01-01

    Reviews current and developing technology uses that are relevant to language assessment and discusses examples of recent linguistic applications from the laboratory at the Educational Testing Service. The processes of language test development are described and the functions they serve from the perspective of a large testing organization are…

  16. Information technology resources assessment

    Energy Technology Data Exchange (ETDEWEB)

    Loken, S.C. [ed.

    1993-01-01

    The emphasis in Information Technology (IT) development has shifted from technology management to information management, and the tools of information management are increasingly at the disposal of end-users, people who deal with information. Moreover, the interactive capabilities of technologies such as hypertext, scientific visualization, virtual reality, video conferencing, and even database management systems have placed in the hands of users a significant amount of discretion over how these resources will be used. The emergence of high-performance networks, as well as network operating systems, improved interoperability, and platform independence of applications will eliminate technical barriers to the use of data, increase the power and range of resources that can be used cooperatively, and open up a wealth of possibilities for new applications. The very scope of these prospects for the immediate future is a problem for the IT planner or administrator. Technology procurement and implementation, integration of new technologies into the existing infrastructure, cost recovery and usage of networks and networked resources, training issues, and security concerns such as data protection and access to experiments are just some of the issues that need to be considered in the emerging IT environment. As managers we must use technology to improve competitiveness. When procuring new systems, we must take advantage of scalable resources. New resources such as distributed file systems can improve access to and efficiency of existing operating systems. In addition, we must assess opportunities to improve information worker productivity and information management through tedmologies such as distributed computational visualization and teleseminar applications.

  17. Photovoltaic technology assessment

    Energy Technology Data Exchange (ETDEWEB)

    Backus, C.E.

    1981-01-01

    After a brief review of the history of photovoltaic devices and a discussion of the cost goals set for photovoltaic modules, the status of photovoltaic technology is assessed. Included are discussions of: current applications, present industrial production, low-cost silicon production techniques, energy payback periods for solar cells, advanced materials research and development, concentrator systems, balance-of-system components. Also discussed are some nontechnical aspects, including foreign markets, US government program approach, and industry attitudes and approaches. (LEW)

  18. Final Technical Report: Characterizing Emerging Technologies.

    Energy Technology Data Exchange (ETDEWEB)

    King, Bruce Hardison [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hansen, Clifford [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Stein, Joshua [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Riley, Daniel [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gonzalez, Sigifredo [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-12-01

    The Characterizing Emerging Technologies project focuses on developing, improving and validating characterization methods for PV modules, inverters and embedded power electronics. Characterization methods and associated analysis techniques are at the heart of technology assessments and accurate component and system modeling. Outputs of the project include measurement and analysis procedures that industry can use to accurately model performance of PV system components, in order to better distinguish and understand the performance differences between competing products (module and inverters) and new component designs and technologies (e.g., new PV cell designs, inverter topologies, etc.).

  19. National implications of high solar and biomass energy growth. Final report of the TASE project. A technology assessment of solar energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Schiffman, Y.M.; D' Alessio, G.

    1982-09-01

    The Technology Assessment of Solar Energy (TASE) Project is a comprehensive multi-year analysis of the environmental, resource and community impacts which could result in the year 2000 if major national incentives were adopted to accelerate solar and biomass energy use. The study uses a comparative approach to examine: (a) the potential impacts of large numbers of solar and biomass units, and (b) the potential reductions in the impacts of new conventional technologies which they would displace. In addition, TASE examines the indirect pollution impacts associated with the manufacturing of solar systems at greater and lesser rates. Overall, massive incentives for solar and biomass energy over the next 20 years can lead to major stress on national capital and finished materials resources as well as to significant air pollution and safety problems. Rapid growth rates for solar systems could markedly increase energy damand in the manufacturing sector. The capital resource and materials problems would derive from emphasis on high, near term growth of solar technologies. The potential environmental and safety problems would derive largely from emphasis on decentralized, uncontrolled biomass combustion. A range of less costly general approaches lies in greater near term emphasis on more mature, competitive technologies, and specifically on biomass rather than solar technologies.In particular this emphasis should be on larger scale biomass technologies with economical pollution controls rather than on small, uncontrolled units; on bio-harvesting safety measures; on larger scale solar technologies which are far less energy and materials intensive and hence less costly than smaller solar technologies per unit energy output; on more gradual growth rates for active solar energy systems, especially small systems.

  20. Comparative assessment of hydrogen storage and international electricity trade for a Danish energy system with wind power and hydrogen/fuel cell technologies. Final project report

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen, Bent (Roskilde University, Energy, Environment and Climate Group, Dept. of Environmental, Social and Spatial Change (ENSPAC) (DK)); Meibom, P.; Nielsen, Lars Henrik; Karlsson, K. (Technical Univ. of Denmark, Risoe National Laboratory for Sustainable Energy, Systems Analysis Dept., Roskilde (DK)); Hauge Pedersen, A. (DONG Energy, Copenhagen (DK)); Lindboe, H.H.; Bregnebaek, L. (ea Energy Analysis, Copenhagen (DK))

    2008-02-15

    This report is the final outcome of a project carried out under the Danish Energy Agency's Energy Research Programme. The aims of the project can be summarized as follows: 1) Simulation of an energy system with a large share of wind power and possibly hydrogen, including economic optimization through trade at the Nordic power pool (exchange market) and/or use of hydrogen storage. The time horizon is 50 years. 2) Formulating new scenarios for situations with and without development of viable fuel cell technologies. 3) Updating software to solve the abovementioned problems. The project has identified a range of scenarios for all parts of the energy system, including most visions of possible future developments. (BA)

  1. Photovoltaic industry manufacturing technology. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Vanecek, D.; Diver, M.; Fernandez, R. [Automation and Robotics Research Inst., Fort Worth, TX (United States)

    1998-08-01

    This report contains the results of the Photovoltaic (PV) Industry Manufacturing Technology Assessment performed by the Automation and Robotics Research Institute (ARRI) of the University of Texas at Arlington for the National Renewable Energy laboratory. ARRI surveyed eleven companies to determine their state-of-manufacturing in the areas of engineering design, operations management, manufacturing technology, equipment maintenance, quality management, and plant conditions. Interviews with company personnel and plant tours at each of the facilities were conducted and the information compiled. The report is divided into two main segments. The first part of the report presents how the industry as a whole conforms to ``World Class`` manufacturing practices. Conclusions are drawn from the results of a survey as to the areas that the PV industry can improve on to become more competitive in the industry and World Class. Appendix A contains the questions asked in the survey, a brief description of the benefits to performing this task and the aggregate response to the questions. Each company participating in the assessment process received the results of their own facility to compare against the industry as a whole. The second part of the report outlines opportunities that exist on the shop floor for improving Process Equipment and Automation Strategies. Appendix B contains the survey that was used to assess each of the manufacturing processes.

  2. Computational fluid dynamics assessment: Volume 1, Computer simulations of the METC (Morgantown Energy Technology Center) entrained-flow gasifier: Final report

    Energy Technology Data Exchange (ETDEWEB)

    Celik, I.; Chattree, M.

    1988-07-01

    An assessment of the theoretical and numerical aspects of the computer code, PCGC-2, is made; and the results of the application of this code to the Morgantown Energy Technology Center (METC) advanced gasification facility entrained-flow reactor, ''the gasifier,'' are presented. PCGC-2 is a code suitable for simulating pulverized coal combustion or gasification under axisymmetric (two-dimensional) flow conditions. The governing equations for the gas and particulate phase have been reviewed. The numerical procedure and the related programming difficulties have been elucidated. A single-particle model similar to the one used in PCGC-2 has been developed, programmed, and applied to some simple situations in order to gain insight to the physics of coal particle heat-up, devolatilization, and char oxidation processes. PCGC-2 was applied to the METC entrained-flow gasifier to study numerically the flash pyrolysis of coal, and gasification of coal with steam or carbon dioxide. The results from the simulations are compared with measurements. The gas and particle residence times, particle temperature, and mass component history were also calculated and the results were analyzed. The results provide useful information for understanding the fundamentals of coal gasification and for assessment of experimental results performed using the reactor considered. 69 refs., 35 figs., 23 tabs.

  3. Health technology assessment in Finland

    DEFF Research Database (Denmark)

    Mäkelä, Marjukka; Roine, Risto P

    2010-01-01

    Since the 1990s, health policy makers in Finland have been supportive of evidence-based medicine and approaches to implement its results. The Finnish Office for Health Technology Assessment (Finohta) has grown from a small start in 1995 to a medium-sized health technology assessment (HTA) agency...

  4. Melter Technologies Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Perez, J.M. Jr. [Pacific Northwest National Lab., Richland, WA (United States); Schumacher, R.F. [Savannah River Technology Center, Aiken, SC (United States); Forsberg, C.W. [Oak Ridge National Lab., TN (United States)

    1996-05-01

    The problem of controlling and disposing of surplus fissile material, in particular plutonium, is being addressed by the US Department of Energy (DOE). Immobilization of plutonium by vitrification has been identified as a promising solution. The Melter Evaluation Activity of DOE`s Plutonium Immobilization Task is responsible for evaluating and selecting the preferred melter technologies for vitrification for each of three immobilization options: Greenfield Facility, Adjunct Melter Facility, and Can-In-Canister. A significant number of melter technologies are available for evaluation as a result of vitrification research and development throughout the international communities for over 20 years. This paper describes an evaluation process which will establish the specific requirements of performance against which candidate melter technologies can be carefully evaluated. Melter technologies that have been identified are also described.

  5. Turbine imaging technology assessment

    Energy Technology Data Exchange (ETDEWEB)

    Moursund, R. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Carlson, T. J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2004-12-01

    The goal of this project was to identify and evaluate imaging technologies for observing juvenile fish within a Kaplan turbine, and specifically that would enable scientists to determine mechanisms of fish injury within an operating turbine unit. This report documents the opportunities and constraints for observing juvenile fish at specific locations during turbine passage. These observations were used to make modifications to dam structures and operations to improve conditions for fish passage while maintaining or improving hydropower production. The physical and hydraulic environment that fish experience as they pass through the hydroelectric plants were studied and the regions with the greatest potential for injury were defined. Biological response data were also studied to determine the probable types of injuries sustained in the turbine intake and what types of injuries are detectable with imaging technologies. The study grouped injury-causing mechanisms into two categories: fluid (pressure/cavitation, shear, turbulence) and mechanical (strike/collision, grinding/pinching, scraping). The physical constraints of the environment, together with the likely types of injuries to fish, provided the parameters needed for a rigorous imaging technology evaluation. Types of technology evaluated included both tracking and imaging systems using acoustic technologies (such as sonar and acoustic tags) and optic technologies (such as pulsed-laser videography, which is high-speed videography using a laser as the flash). Criteria for determining image data quality such as frame rate, target detectability, and resolution were used to quantify the minimum requirements of an imaging sensor.

  6. Technological changes in cancer prevention

    Energy Technology Data Exchange (ETDEWEB)

    Fishbein, L. (International Life Sciences Institute, Washington (United States). Risk Science Institute)

    1992-01-01

    Exposures and technologies in the workplace are changing due to a variety of factors, including newly developed technologies, mechanization and automation, and improvements in industrial hygiene primarily effected in many developed countries. In addition substitution and removal of carcinogenic constituents in the workplace and general environment are increasing in a number of instances, particularly in North America, Western Europe, and Japan, and they are being accompanied as well by remediation either by source reduction, recycling, or compliance to more stringent national and international regulations and standards. This overview highlights some of the strategies employed in the technological ages in cancer prevention and cites examples in source reduction, changes in formulation, product or process changes, recycling, and hazardous materials management

  7. Technological changes in cancer prevention.

    Science.gov (United States)

    Fishbein, L

    1992-01-01

    Exposures and technologies in the workplace are changing due to a variety of factors, including newly developed technologies, mechanization and automation, and improvements in industrial hygiene primarily effected in many developed countries. In addition substitution and removal of carcinogenic constituents in the workplace and general environment are increasing in a number of instances, particularly in North America, Western Europe, and Japan, and they are being accompanied as well by remediation either by source reduction, recycling, or compliance to more stringent national and international regulations and standards. This overview highlights some of the strategies employed in the technological changes in cancer prevention and cites examples in source reduction, changes in formulation, product or process changes, recycling, and hazardous materials management.

  8. Superconducting Technology Assessment

    Science.gov (United States)

    2005-08-01

    of Nb/Al- Nx /NbTiN junctions for SIS mixer applications,” IEEE Trans. Appl. Superconduct., vol. 11, pp. 76–79, Mar. 2001. [48] M. Gurvitch, W. A...Another connector developed by IBM for commercial applications using a dendritic interposer technology. A “beam-on-pad” approach developed by Siemens

  9. Medicine: The final frontier in cancer diagnosis

    Science.gov (United States)

    Leachman, Sancy A.; Merlino, Glenn

    2017-01-01

    A computer, trained to classify skin cancers using image analysis alone, can now identify certain cancers as successfully as can skin-cancer doctors. What are the implications for the future of medical diagnosis? See Letter p.115

  10. Quantification of environmental impacts of various energy technologies. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Selfors, A. [ed.

    1994-10-01

    This report discusses problems related to economic assessment of the environmental impacts and abatement measures in connection with energy projects. Attention is called to the necessity of assessing environmental impacts both in the form of reduced economic welfare and in the form of costs of abatement measures to reduce the impact. In recent years, several methods for valuing environmental impacts have been developed, but the project shows that few empirical studies have been carried out. The final report indicates that some important factors are very difficult to evaluate. In addition environmental impacts of energy development in Norway vary considerably from project to project. This makes it difficult to obtain a good basis for comparing environmental impacts caused by different technologies, for instance hydroelectric power versus gas power or wind versus hydroelectric power. It might be feasible however to carry out more detailed economic assessments of environmental impacts of specific projects. 33 refs., 1 fig., 4 tabs.

  11. Expedited technology demonstration project final report: final forms

    Energy Technology Data Exchange (ETDEWEB)

    Hopper, R W

    1999-05-01

    ETDP Final Forms was an attempt to demonstrate the fabrication and performance of a ceramic waste form immobilizing the hazardous and radioactive elements of the MSO/SR mineral residues. The ceramic material had been developed previously. The fabrication system was constructed and functioned as designed except for the granulator. Fabrication of our particular ceramic, however, proved unsatisfactory. The ceramic material design was therefore changed toward the end of the project, replacing nepheline with zircon as the sink for silica. Preliminary results were encouraging, but more development is needed. Fabrication of the new ceramic requires major changes in the processing: Calcination and granulation would be replaced by spray drying; and sintering would be at higher temperature. The main goal of the project--demonstrating the fabrication and performance of the waste form--was not achieved. This report summarizes Final Forms' activities. The problem of immobilizing the MSO/SR mineral residues is discussed.

  12. UN-aided Project Passing Final Assessment

    Institute of Scientific and Technical Information of China (English)

    Wang Anfang

    1995-01-01

    @@ A number of projects funded by the United Nations Development Program passed final examination and assessment in April 1994.They are the well-completion technical center project of the Southwest Petroleum Institute with a fund of 1.27 million US dollars and the acidizing and fracturing technical service center of Wanzhuang Branch Research Institute of Petroleum Exploration and Development (RIPED) with a fund of 1.41 million US dollars.

  13. Spent Nuclear Fuel Alternative Technology Risk Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Perella, V.F.

    1999-11-29

    A Research Reactor Spent Nuclear Fuel Task Team (RRTT) was chartered by the Department of Energy (DOE) Office of Spent Fuel Management with the responsibility to recommend a course of action leading to a final technology selection for the interim management and ultimate disposition of the foreign and domestic aluminum-based research reactor spent nuclear fuel (SNF) under DOE''s jurisdiction. The RRTT evaluated eleven potential SNF management technologies and recommended that two technologies, direct co-disposal and an isotopic dilution alternative, either press and dilute or melt and dilute, be developed in parallel. Based upon that recommendation, the Westinghouse Savannah River Company (WSRC) organized the SNF Alternative Technology Program to further develop the direct co-disposal and melt and dilute technologies and provide a WSRC recommendation to DOE for a preferred SNF alternative management technology. A technology risk assessment was conducted as a first step in this recommendation process to determine if either, or both, of the technologies posed significant risks that would make them unsuitable for further development. This report provides the results of that technology risk assessment.

  14. Research guidance studies to assess gasoline from coal by methanol-to-gasoline and sasol-type Fischer--Tropsch technologies. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Schreiner, M.

    1978-08-01

    This study provides a technical and economic comparison between the new Mobil methanol-to-gasoline technology under development and the commercially available Fischer--Tropsch technology for the production of motor gasoline meeting U.S. quality standards. Conceptual plant complexes, sited in Wyoming, are complete grass-roots facilities. The Lurgi dry-ash, pressure technology is used to gasify sub-bituminous strip coal. Except for the Mobil process, processes used are commercially available. Coproduction of products, namely SNG, LPG and gasoline, is practiced. Four sensitivity cases have also been developed in less detail from the two base cases. In all areas, the Mobil technology is superior to Fischer--Tropsch: process complexity, energy usage, thermal efficiency, gasoline selectivity, gasoline quality, investment and gasoline selectivity, gasoline quality, investment and gasoline cost. Principal advantages of the Mobil process are its selective yield of excellent quality gasoline with minimum ancillary processing. Fischer--Tropsch not only yields a spectrum of products, but the production of a gasoline meeting U.S. specifications is difficult and complex. This superiority results in about a 25% reduction in the gasoline cost. Sensitivity study conclusions include: (1) the conversion of methanol into gasoline over the Mobil catalyst is highly efficient, (2) if SNG is a valuable product, increased gasoline yield via the reforming of SNG is uneconomical, and (3) fluid-bed operation is somewhat superior to fixed-bed operation for the Mobil methanol conversion technology.

  15. Assessing Advanced Technology in CENATE

    Energy Technology Data Exchange (ETDEWEB)

    Tallent, Nathan R.; Barker, Kevin J.; Gioiosa, Roberto; Marquez, Andres; Kestor, Gokcen; Song, Shuaiwen; Tumeo, Antonino; Kerbyson, Darren J.; Hoisie, Adolfy

    2016-08-08

    PNNL's Center for Advanced Technology Evaluation (CENATE) is a new U.S. Department of Energy center whose mission is to assess and facilitate access to emerging computing technology. CENATE is assessing a range of advanced technologies, from evolutionary to disruptive. Technologies of interest include the processor socket (homogeneous and accelerated systems), memories (dynamic, static, memory cubes), motherboards, networks (network interface cards and switches), and input/output and storage devices. CENATE is developing a multi-perspective evaluation process based on integrating advanced system instrumentation, performance measurements, and modeling and simulation. We show evaluations of two emerging network technologies: silicon photonics interconnects and the Data Vortex network. CENATE's evaluation also addresses the question of which machine is best for a given workload under certain constraints. We show a performance-power tradeoff analysis of a well-known machine learning application on two systems.

  16. Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer in Women

    Science.gov (United States)

    ... Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-related Cancer in Women The U.S. Preventive Services ... Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-related Cancer in Women. This final recommendation statement ...

  17. Smart Gun Technology project. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Weiss, D.R.

    1996-05-01

    The goal of the Smart Gun Technology project is to eliminate the capability of an unauthorized user form firing a law officer`s firearm by implementing user-recognizing-and-authorizing (or {open_quotes}smart{close_quotes}) surety technologies. This project was funded by the National Institute of Justice. This report lists the findings and results of the project`s three primary objectives. First, to find and document the requirements for a smart firearm technology that law enforcement officers will value. Second, to investigate, evaluate, and prioritize technologies that meet the requirements for a law enforcement officer`s smart firearm. Third, to demonstrate and document the most promising technology`s usefulness in models of a smart firearm.

  18. Innovative Technology Development Program. Final summary report

    Energy Technology Data Exchange (ETDEWEB)

    Beller, J.

    1995-08-01

    Through the Office of Technology Development (OTD), the U.S. Department of Energy (DOE) has initiated a national applied research, development, demonstration, testing, and evaluation program, whose goal has been to resolve the major technical issues and rapidly advance technologies for environmental restoration and waste management. The Innovative Technology Development (ITD) Program was established as a part of the DOE, Research, Development, Demonstration, Testing, and Evaluation (RDDT&E) Program. The plan is part of the DOE`s program to restore sites impacted by weapons production and to upgrade future waste management operations. On July 10, 1990, DOE issued a Program Research and Development Announcement (PRDA) through the Idaho Operations Office to solicit private sector help in developing innovative technologies to support DOE`s clean-up goals. This report presents summaries of each of the seven projects, which developed and tested the technologies proposed by the seven private contractors selected through the PRDA process.

  19. Risk assessment meta tool LDRD final report.

    Energy Technology Data Exchange (ETDEWEB)

    Bouchard, Ann Marie; Osbourn, Gordon Cecil

    2006-12-01

    The goal of this project was to develop a risk analysis meta tool--a tool that enables security analysts both to combine and analyze data from multiple other risk assessment tools on demand. Our approach was based on the innovative self-assembling software technology under development by the project team. This technology provides a mechanism for the user to specify his intentions at a very high level (e.g., equations or English-like text), and then the code self-assembles itself, taking care of the implementation details. The first version of the meta tool focused specifically in importing and analyzing data from Joint Conflict and Tactical Simulation (JCATS) force-on-force simulation. We discuss the problem, our approach, technical risk, and accomplishments on this project, and outline next steps to be addressed with follow-on funding.

  20. Assessment of strength-limiting flaws in ceramic heat exchanger components INEL support: Fracture mechanics and nondestructive evaluation technology. Final report, June 1, 1986--May 31, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Lloyd, W.R.; Reuter, W.G.

    1993-06-01

    An examination of a siliconized SiC material, CS101K, has been performed to determine if linear fracture mechanics concepts can be used to characterize and predict the behavior of this material. Phase II of this project showed that a value that appeared to represent the true fracture toughness could be measured using small specimens with a machined notch, if the notch root radius was less than 75 {mu}m. Methods to produce sharply cracked specimens were then investigated to verify this hypothesis. A new technique, called the {open_quotes}beam support{close_quotes} precracking method, was subsequently developed and used to make sharply cracked SE(B) specimens. Tests of these specimens showed a slightly rising R-curve-type of behavior, with elevated values of plane strain fracture toughness. Interference of the crack surfaces in the precrack wake was hypothesized as the most likely cause of these phenomena. Subsequent testing with various precrack lengths provided preliminary verification of the hypothesis. Test results show that, for fracture mechanics-based design and assessment, adequate values of fracture toughness can be obtained from EDM-notched specimens, instead of the more costly precracked specimens. These results imply that, for the Si-SiC material tested, caution is warranted when using any of the methods of assessing fracture toughness that use a sharp precrack. It is also reasoned that these results may generally be more applicable to the coarser-grained structural ceramics that exhibit a rougher fracture surface. Based on results of testing EDM-notched bend specimens in 1250{degrees}C air, no degradation of material properties were observed for exposures, under applied stress, up to 900 h. Instead, some increase in fracture toughness was measured for these conditions. These same tests indicated that the threshold stress intensity factor for stress corrosion cracking (static fatigue) in the hot air environment was the same as the fracture toughness.

  1. Texas Public School Technology Survey, 1988. Final Report.

    Science.gov (United States)

    Denton, Jon; Davis, Trina; Strader, Arlen; Jessup, George

    The Texas Association of School Administrators (TASA) with technical support from the South Central Regional Technology in Education Consortia-Texas (SCR*TEC-TX) conducted a survey of the technology infrastructure in all public schools in Texas. This document provides the final report of the 1998 Texas Public School Technology Survey. Following…

  2. Security Assessment Simulation Toolkit (SAST) Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Meitzler, Wayne D.; Ouderkirk, Steven J.; Hughes, Chad O.

    2009-11-15

    The Department of Defense Technical Support Working Group (DoD TSWG) investment in the Pacific Northwest National Laboratory (PNNL) Security Assessment Simulation Toolkit (SAST) research planted a technology seed that germinated into a suite of follow-on Research and Development (R&D) projects culminating in software that is used by multiple DoD organizations. The DoD TSWG technology transfer goal for SAST is already in progress. The Defense Information Systems Agency (DISA), the Defense-wide Information Assurance Program (DIAP), the Marine Corps, Office Of Naval Research (ONR) National Center For Advanced Secure Systems Research (NCASSR) and Office Of Secretary Of Defense International Exercise Program (OSD NII) are currently investing to take SAST to the next level. PNNL currently distributes the software to over 6 government organizations and 30 DoD users. For the past five DoD wide Bulwark Defender exercises, the adoption of this new technology created an expanding role for SAST. In 2009, SAST was also used in the OSD NII International Exercise and is currently scheduled for use in 2010.

  3. Assessment of technologies for CO{sub 2} capture and storage. Final report; Verfahren zur CO{sub 2}-Abscheidung und -Speicherung. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Radgen, Peter; Cremer, Clemens; Warkentin, Sebastian [Fraunhofer-Inst. fuer Systemtechnik und Innovationsforschung, Karlsruhe (Germany); Gerling, Peter; May, Franz; Knopf, Stephan [Bundesanstalt fuer Geowissenschaften und Rohstoffe, Hannover (Germany)

    2006-08-15

    The aim of this study was to summarize the actual status for carbon capture, transport and storage for CO{sub 2} emissions from power stations. Special interest was given to the implications from the introduction of carbon capture and storage in power stations on the efficiency, emissions and cost for electricity generation. In the beginning a detailed analyses of the national, European and international activities in this field have been conducted. The analysis focussed on the identification of main actors and the different co-operation of actors. To do so, the available literature has been studied and analysed with a bibliometric approach, which has taken also presentations at national and international conferences into account. In a second step a technical analysis has been undertaken for the three main routes for carbon capture (pre-combustion capture; post-combustion capture, oxy-fuel combustion) with a special emphasis on the impact to the Environment. Truck, ship and pipeline transport have been analysed as means for transporting the CO{sub 2} from the power station to the storage site. In addition the different storage options for a secure long term storage of the captured CO{sub 2} are studied in the report. Special attention was given to the storage options in gasfields and saline aquifers which will be the most promising options in Germany. The report gives an actual overview on the status of carbon capture and storage in the world. It therefore supports the decision making process when introducing this new technology, taking into account the environmental effects. (orig.)

  4. Final Report: Radiation Health Technology Curriculum.

    Science.gov (United States)

    Marshall, Dwight A.; Hunt, Hiram M.

    This report describes all aspects of a radiation health technology program at a lower-division college level. Such a program must include certain basic courses, plus supplementary ones to meet the needs of local employers. To implement and sustain a curriculum, the college must (1) determine the need for it, (2) establish its objectives, (3)…

  5. Clean cast steel technology. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Bates, C.E.; Griffin, J.A.

    1998-06-01

    This report documents the results obtained from the Clean Cast Steel Technology Program financially supported by the DOE Metal Casting Competitiveness Research Program and industry. The primary objective of this program is to develop technology for delivering steel free of oxide macroinclusions to mold cavities. The overall objective is to improve the quality of cast steel by developing and demonstrating the technology for substantially reducing surface and sub-surface oxide inclusions. Two approaches are discussed here. A total of 23 castings were produced by submerge pouring along with sixty conventionally poured castings. The submerged poured castings contained, on average, 96% fewer observable surface inclusions (11.9 vs 0.4) compared to the conventionally poured cast parts. The variation in the population of surface inclusions also decreased by 88% from 5.5 to 0.7. The machinability of the casting was also improved by submerged pouring. The submerge poured castings required fewer cutting tool changes and less operator intervention during machining. Subsequent to these trials, the foundry has decided to purchase more shrouds for continued experimentation on other problem castings where submerge pouring is possible. An examination of melting and pouring practices in four foundries has been carried out. Three of the four foundries showed significant improvement in casting quality by manipulating the melting practice. These melting practice variables can be grouped into two separate categories. The first category is the pouring and filling practice. The second category concerns the concentration of oxidizable elements contained in the steel. Silicon, manganese, and aluminum concentrations were important factors in all four foundries. Clean heats can consistently be produced through improved melting practice and reducing exposure of the steel to atmospheric oxygen during pouring and filling.

  6. Integrated environmentally compatible soldering technologies. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Hosking, F.M.; Frear, D.R.; Iman, R.L.; Keicher, D.M.; Lopez, E.P.; Peebles, H.C.; Sorensen, N.R.; Vianco, P.T.

    1994-05-01

    Chemical fluxes are typically used during conventional electronic soldering to enhance solder wettability. Most fluxes contain very reactive, hazardous constituents that require special storage and handling. Corrosive flux residues that remain on soldered parts can severely degrade product reliability. The residues are removed with chlorofluorocarbon (CFC), hydrochlorofluorocarbon (HCFC), or other hazardous solvents that contribute to ozone depletion, release volatile organic compounds into the atmosphere, or add to the solvent waste stream. Alternative materials and processes that offer the potential for the reduction or elimination of cleaning are being developed to address these environmental issues. Timing of the effort is critical, since the targeted chemicals will soon be heavily taxed or banned. DOE`s Office of Environmental Restoration and Waste Management (DOE/EM) has supported Sandia National Laboratories` Environmentally Conscious Manufacturing Integrated Demonstration (ECMID). Part of the ECM program involves the integration of several environmentally compatible soldering technologies for assembling electronics devices. Fluxless or {open_quotes}low-residue/no clean{close_quotes} soldering technologies (conventional and ablative laser processing, controlled atmospheres, ultrasonic tinning, protective coatings, and environmentally compatible fluxes) have been demonstrated at Sandia (SNL/NM), the University of California at Berkeley, and Allied Signal Aerospace-Kansas City Division (AS-KCD). The university demonstrations were directed under the guidance of Sandia staff. Results of the FY93 Soldering ID are presented in this report.

  7. Technology Pathway Partnership Final Scientific Report

    Energy Technology Data Exchange (ETDEWEB)

    Hall, John C. Dr.; Godby, Larry A.

    2012-04-26

    This report covers the scientific progress and results made in the development of high efficiency multijunction solar cells and the light concentrating non-imaging optics for the commercial generation of renewable solar energy. During the contract period the efficiency of the multijunction solar cell was raised from 36.5% to 40% in commercially available fully qualified cells. In addition significant strides were made in automating production process for these cells in order to meet the costs required to compete with commercial electricity. Concurrent with the cells effort Boeing also developed a non imaging optical systems to raise the light intensity at the photovoltaic cell to the rage of 800 to 900 suns. Solar module efficiencies greater than 30% were consistently demonstrated. The technology and its manufacturing were maturated to a projected price of < $0.015 per kWh and demonstrated by automated assembly in a robotic factory with a throughput of 2 MWh/yr. The technology was demonstrated in a 100 kW power plant erected at California State University Northridge, CA.

  8. Augmented Reality Tower Technology Assessment

    Science.gov (United States)

    Reisman, Ronald J.; Brown, David M.

    2009-01-01

    Augmented Reality technology may help improve Air Traffic Control Tower efficiency and safety during low-visibility conditions. This paper presents the assessments of five off-duty controllers who shadow-controlled' with an augmented reality prototype in their own facility. Initial studies indicated unanimous agreement that this technology is potentially beneficial, though the prototype used in the study was not adequate for operational use. Some controllers agreed that augmented reality technology improved situational awareness, had potential to benefit clearance, control, and coordination tasks and duties and could be very useful for acquiring aircraft and weather information, particularly aircraft location, heading, and identification. The strongest objections to the prototype used in this study were directed at aircraft registration errors, unacceptable optical transparency, insufficient display performance in sunlight, inadequate representation of the static environment and insufficient symbology.

  9. Review on early technology assessments of nanotechnologies in oncology.

    Science.gov (United States)

    Retèl, Valesca P; Hummel, Marjan J M; van Harten, Wim H

    2009-12-01

    Nanotechnology is expected to play an increasingly important role in the diagnostics, prognostics, and management of targeted cancer treatments. While papers have described promising results for nanotechnology in experimental settings, the translation of fundamental research into clinical applications has yet to be widely adopted. In future, policy makers will need to anticipate new developments for clinical implementation and introduce technology assessments. Here we present an overview of the literature on the technology assessments that have already been undertaken on early stage nanotechnology in cancer care, with particular emphasis placed on clinical efficacy, efficiency, logistics, patient-related features and technology dynamics. Owing to the current stage of development of most nanotechnologies, we found only a limited number of publications describing the application of either Health Technology Assessment (HTA) or Constructive Technology Assessment (CTA). In spite of the promising conclusions of most papers concerning the benefits of clinical implementation, actual clinically relevant applications were rarely encountered, and so far only a few publications report application of systematic forms of technology assessment. Most articles consider aspects of environmental safety, regulation and ethics, often mentioning the need to investigate such issues more thoroughly. Evaluation of financial and organizational aspects is often missing. In order to obtain a realistic perspective on the translation and implementation process there is a need for a broad and systematic evaluation of nanotechnologies at early stages of development. Assessment methods taking technology dynamics into account, such as Constructive Technology Assessment (CTA) should be considered for evaluation purposes.

  10. Health technology assessment in Singapore.

    Science.gov (United States)

    Pwee, Keng Ho

    2009-07-01

    The Republic of Singapore is an island city-state in Southeast Asia. Its population enjoys good health and the Singapore Ministry of Health's mission is to promote good health and reduce illness, ensure access to good and affordable health care, and pursue medical excellence. This is achieved through a healthcare system that includes both private and public sector elements. The financing philosophy of Singapore's healthcare delivery system is based on individual responsibility and community support. Health care in Singapore is financed by a combination of taxes, employee medical benefits, compulsory health savings, insurance, and out-of-pocket payment. The capability for health technology assessment in Singapore was developed concurrently with its medical device regulation system in the 1990s. The first formal unit with health technology assessment (HTA) functions was established in September 1995. Today, HTA features in decision making for the Standard Drug List, licensing of medical clinics, the Health Service Development Programme, healthcare subsidies, and policy development. The public sector healthcare delivery clusters have also recently started health services research units with HTA functions. Singapore is organizing the 6th Health Technology Assessment International (HTAi) Annual Meeting in June 2009. Bringing this prestigious international conference to Asia for the first time will help raise awareness of HTA in the region.

  11. Cancer risk assessment of toxaphene.

    Science.gov (United States)

    Buranatrevedh, Surasak

    2004-07-01

    The primary purpose is to do cancer risk assessment of toxaphene by using four steps of risk assessment proposed by the United States National Academy of Sciences/National Research Council (NAS/NRC). Four steps of risk assessment including hazard identification, dose-response relationship, exposure assessment, and risk characterization were used to evaluate cancer risk of toxaphene. Toxaphene was the most heavily used insecticide in many parts of the world before it was banned in 1982. It increased incidence of neoplasms of liver and uterus in mice and increased incidence of neoplasms of endocrine organs, thyroid, pituitary, adrenal, mammary glands, and reproductive systems in rats. From mice's and rats' study, slope factor for toxaphene is 0.8557 (mg/ kg/day)(-1). Lifetime average daily dose (LADD) of toxaphene from ambient air, surface water, soil, and fish were 1.08 x 10(-6), 5.71 x 10(-6), 3.43 x 10(-7), and 7.96 x 10(-5) mg/kg/day, respectively. Cancer risk of toxaphene for average exposure is 7.42 x 10(-5). From this study, toxaphene might have carcinogenic risk among humans.

  12. Evaluation and Assessment in Educational Information Technology.

    Science.gov (United States)

    Liu, Leping, Ed.; Johnson, D. LaMont, Ed.; Maddux, Cleborne D., Ed.; Henderson, Norma J., Ed.

    This book contains the following articles on evaluating and assessing educational information technology: (1) "Assessing Learning in the New Age of Information Technology in Education" (Leping Liu, D. LaMont Johnson, Cleborne D. Maddux, and Norma J. Henderson); (2) "Instruments for Assessing the Impact of Technology in Education" (Rhonda…

  13. Constructive Technology Assessment (CTA) as a tool in coverage with evidence development: the case of the 70-gene prognosis signature for breast cancer diagnostics

    NARCIS (Netherlands)

    Retèl, Valesca P.; Bueno-de-Mesquita, Jolien M.; Hummel, Marjan J.M.; Vijver, van de Marc J.; Douma, Kirsten F.L.; Karsenberg, Kim; Dam, van Frits S.A.M.; Krimpen, van Cees; Bellot, Frank E.; Roumen, Rudi M.H.; Linn, Sabine C.; Harten, van Wim H.

    2009-01-01

    Objectives: Constructive Technology Assessment (CTA) is a means to guide early implementation of new developments in society, and can be used as an evaluation tool for Coverage with Evidence Development (CED). We used CTA for the introduction of a new diagnostic test in the Netherlands, the 70-gene

  14. HVDC power transmission technology assessment

    Energy Technology Data Exchange (ETDEWEB)

    Hauth, R.L.; Tatro, P.J.; Railing, B.D. [New England Power Service Co., Westborough, MA (United States); Johnson, B.K.; Stewart, J.R. [Power Technologies, Inc., Schenectady, NY (United States); Fink, J.L.

    1997-04-01

    The purpose of this study was to develop an assessment of the national utility system`s needs for electric transmission during the period 1995-2020 that could be met by future reduced-cost HVDC systems. The assessment was to include an economic evaluation of HVDC as a means for meeting those needs as well as a comparison with competing technologies such as ac transmission with and without Flexible AC Transmission System (FACTS) controllers. The role of force commutated dc converters was to be assumed where appropriate. The assessment begins by identifying the general needs for transmission in the U.S. in the context of a future deregulated power industry. The possible roles for direct current transmission are then postulated in terms of representative scenarios. A few of the scenarios are illustrated with the help of actual U.S. system examples. non-traditional applications as well as traditional applications such as long lines and asynchronous interconnections are discussed. The classical ``break-even distance`` concept for comparing HVDC and ac lines is used to assess the selected scenarios. The impact of reduced-cost converters is reflected in terms of the break-even distance. This report presents a comprehensive review of the functional benefits of HVDC transmission and updated cost data for both ac and dc system components. It also provides some provocative thoughts on how direct current transmission might be applied to better utilize and expand our nation`s increasingly stressed transmission assets.

  15. Technology modernization assessment flexible automation

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, D.W.; Boyd, D.R.; Hansen, N.H.; Hansen, M.A.; Yount, J.A.

    1990-12-01

    The objectives of this report are: to present technology assessment guidelines to be considered in conjunction with defense regulations before an automation project is developed to give examples showing how assessment guidelines may be applied to a current project to present several potential areas where automation might be applied successfully in the depot system. Depots perform primarily repair and remanufacturing operations, with limited small batch manufacturing runs. While certain activities (such as Management Information Systems and warehousing) are directly applicable to either environment, the majority of applications will require combining existing and emerging technologies in different ways, with the special needs of depot remanufacturing environment. Industry generally enjoys the ability to make revisions to its product lines seasonally, followed by batch runs of thousands or more. Depot batch runs are in the tens, at best the hundreds, of parts with a potential for large variation in product mix; reconfiguration may be required on a week-to-week basis. This need for a higher degree of flexibility suggests a higher level of operator interaction, and, in turn, control systems that go beyond the state of the art for less flexible automation and industry in general. This report investigates the benefits and barriers to automation and concludes that, while significant benefits do exist for automation, depots must be prepared to carefully investigate the technical feasibility of each opportunity and the life-cycle costs associated with implementation. Implementation is suggested in two ways: (1) develop an implementation plan for automation technologies based on results of small demonstration automation projects; (2) use phased implementation for both these and later stage automation projects to allow major technical and administrative risk issues to be addressed. 10 refs., 2 figs., 2 tabs. (JF)

  16. Colon Cancer Risk Assessment - Gauss Program

    Science.gov (United States)

    An executable file (in GAUSS) that projects absolute colon cancer risk (with confidence intervals) according to NCI’s Colorectal Cancer Risk Assessment Tool (CCRAT) algorithm. GAUSS is not needed to run the program.

  17. Early phase Technology Assessment of nanotechnology in oncology

    NARCIS (Netherlands)

    Retèl, Valesca P.; Hummel, Marjan J.M.; Harten, van Willem H.

    2008-01-01

    To perform early Technology Assessment (TA) of nanotechnology in oncology. The possibilities of nanotechnology for detection (imaging), diagnosis and treatment of cancer are subject of different research programs where major investments are concerned. As a range of bio- nanotechnologies is expected

  18. ELECTRIC INFRASTRUCTURE TECHNOLOGY, TRAINING, AND ASSESSMENT PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    TREMEL, CHARLES L

    2007-06-28

    The objective of this Electric Infrastructure Technology, Training and Assessment Program was to enhance the reliability of electricity delivery through engineering integration of real-time technologies for wide-area applications enabling timely monitoring and management of grid operations. The technologies developed, integrated, tested and demonstrated will be incorporated into grid operations to assist in the implementation of performance-based protection/preventive measures into the existing electric utility infrastructure. This proactive approach will provide benefits of reduced cost and improved reliability over the typical schedule-based and as needed maintenance programs currently performed by utilities. Historically, utilities have relied on maintenance and inspection programs to diagnose equipment failures and have used the limited circuit isolation devices, such as distribution main circuit breakers to identify abnormal system performance. With respect to reliable problem identification, customer calls to utility service centers are often the sole means for utilities to identify problem occurrences and determine restoration methodologies. Furthermore, monitoring and control functions of equipment and circuits are lacking; thus preventing timely detection and response to customer outages. Finally, the two-way flow of real-time system information is deficient, depriving decision makers of key information required to effectively manage and control current electric grid demands to provide reliable customer service in abnormal situations. This Program focused on advancing technologies and the engineering integration required to incorporate them into the electric grid operations to enhance electrical system reliability and reduce utility operating costs.

  19. Technology-assisted dietary assessment

    Science.gov (United States)

    Zhu, Fengqing; Mariappan, Anand; Boushey, Carol J.; Kerr, Deb; Lutes, Kyle D.; Ebert, David S.; Delp, Edward J.

    2008-02-01

    Dietary intake provides valuable insights for mounting intervention programs for prevention of disease. With growing concern for adolescent obesity, the need to accurately measure diet becomes imperative. Assessment among adolescents is problematic as this group has irregular eating patterns and have less enthusiasm for recording food intake. Preliminary studies among adolescents suggest that innovative use of technology may improve the accuracy of diet information from young people. In this paper, we propose a novel food record method using a mobile device that will provide an accurate account of daily food and nutrient intake among adolescents. Our approach includes the use of image analysis tools for identification and quantification of food consumption. Images obtained before and after food is consumed can be used to estimate the diet of an individual. In this paper we describe our initial results and indicate the potential of the proposed system.

  20. Fuzzy sets applications for cancer risk assessment.

    Science.gov (United States)

    Molchanov, P A; Dudatiev, A V; Podobna, Y Y; Molchanova, O P

    2002-09-01

    The method of cancer risk assessment on the basis of the Fuzzy Set Theory is presented. The method is based on a multifactor risk assessment of cancer diseases. The individual risk of cancer disease is evaluated as the probability of disease multiplied by the value of an individual dose. An acupuncture method of cancer risk assessments was developed. The method is based on the analysis of changes of an electromagnetic field (biofield) of a person. The method allows to determine both cancer probability and probable location of the process.

  1. ENDOSCOPIC TECHNOLOGIES IN EARLY RECTAL CANCER TREATMENT

    Directory of Open Access Journals (Sweden)

    D. V. Samsonov

    2015-01-01

    Full Text Available Total mesorectal excision is the “golden standard” of surgical treatment for rectal cancer. Development of endoscopic technologies allowed to implement the benefits of minimally invasive surgery in early rectal cancer treatment, decrease morbidity and mortality, improve functional outcome and quality of life. Oncological safety of this method is still a subject for discussion due to lack of lymph node harvest. Endoscopic operations for early rectal cancer are being actively implemented in daily practice, but lack of experience does not allow to include this method in national clinical prac-tice guidelines.

  2. ASSESSMENT OF QUALITY OF INNOVATIVE TECHNOLOGIES

    Directory of Open Access Journals (Sweden)

    Larisa Alexejevna Ismagilova

    2016-12-01

    Full Text Available We consider the topical issue of implementation of innovative technologies in the aircraft engine building industry. In this industry, products with high reliability requirements are developed and mass-produced. These products combine the latest achievements of science and technology. To make a decision on implementation of innovative technologies, a comprehensive assessment is carried out. It affects the efficiency of the innovations realization. In connection with this, the assessment of quality of innovative technologies is a key aspect in the selection of technological processes for their implementation. Problems concerning assessment of the quality of new technologies and processes of production are considered in the suggested method with respect to new positions. The developed method of assessing the quality of innovative technologies stands out for formed system of the qualimetric characteristics ensuring the effectiveness, efficiency, adaptability of innovative technologies and processes. The feature of suggested system of assessment is that it is based on principles of matching and grouping of quality indicators of innovative technologies and the characteristics of technological processes. The indicators are assessed from the standpoint of feasibility, technologies competiveness and commercial demand of products. In this paper, we discuss the example of implementing the approach of assessing the quality of the innovative technology of high-tech products such as turbine aircraft engine.

  3. Decision Gate Process for Assessment of a Technology Development Portfolio

    Science.gov (United States)

    Kohli, Rajiv; Fishman, Julianna; Hyatt, Mark

    2012-01-01

    The NASA Dust Management Project (DMP) was established to provide technologies (to TRL 6 development level) required to address adverse effects of lunar dust to humans and to exploration systems and equipment, which will reduce life cycle cost and risk, and will increase the probability of sustainable and successful lunar missions. The technology portfolio of DMP consisted of different categories of technologies whose final product is either a technology solution in itself, or one that contributes toward a dust mitigation strategy for a particular application. A Decision Gate Process (DGP) was developed to assess and validate the achievement and priority of the dust mitigation technologies as the technologies progress through the development cycle. The DGP was part of continuous technology assessment and was a critical element of DMP risk management. At the core of the process were technology-specific criteria developed to measure the success of each DMP technology in attaining the technology readiness levels assigned to each decision gate. The DGP accounts for both categories of technologies and qualifies the technology progression from technology development tasks to application areas. The process provided opportunities to validate performance, as well as to identify non-performance in time to adjust resources and direction. This paper describes the overall philosophy of the DGP and the methodology for implementation for DMP, and describes the method for defining the technology evaluation criteria. The process is illustrated by example of an application to a specific DMP technology.

  4. Minidoka Dam Wildlife Impact Assessment: Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Robert C.; Meuleman, G. Allyn

    1989-03-01

    A wildlife impact assessment has been developed for the US Bureau of Reclamation's Minidoka Dam and Reservoir in south central Idaho. This assessment was conducted to fulfill requirements of the Fish and Wildlife Program. Specific objectives of this study included the following: select target wildlife species, and identify their current status and management goals; estimate the net effects on target wildlife species resulting from hydroelectric development and operation; recommend protection, mitigation, and enhancement goals for target wildlife species affected by hydroelectric development and operation; and consult and coordinate impact assessment activities with the Northwest Power Planning Council, Bonneville Power Administration, US Bureau of Reclamation, Bureau of Land Management, Shoshone-Bannock Tribes, US Fish and Wildlife Service, Pacific Northwest Utilities Conference Committee, and other entities expressing interest in the project. 62 refs., 2 figs., 11 tabs.

  5. Economic Feasibility and Market Readiness of Solar Technologies. Draft Final Report. Volume I.

    Energy Technology Data Exchange (ETDEWEB)

    Flaim, Silvio J.; Buchanan, Deborah L.; Christmas, Susan; Fellhauer, Cheryl; Glenn, Barbara; Ketels, Peter A.; Levary, Arnon; Mourning, Pete; Steggerda, Paul; Trivedi, Harit; Witholder, Robert E.

    1978-09-01

    Systems descriptions, costs, technical and market readiness assessments are reported for ten solar technologies: solar heating and cooling of buildings (SHACOB), passive, agricultural and industrial process heat (A/IPH), biomass, ocean thermal (OTEC), wind (WECS), solar thermal electric, photovoltaics, satellite power station (SPS), and solar total energy systems (STES). Study objectives, scope, and methods. are presented. of Joint Task The cost and market analyses portion 5213/6103 will be used to make commercialization assessments in the conclusions of. the final report.

  6. Final environmental assessment: Sacramento Energy Service Center

    Energy Technology Data Exchange (ETDEWEB)

    1994-03-01

    The Sacramento Area Office (SAO) of the Western Area Power Administration (Western) needs to increase the security of operations, to eliminate overcrowding at the current leased location of the existing facilities, to provide for future growth, to improve efficiency, and to reduce operating costs. The proposed action is to construct an approximate 40,000-square foot building and adjacent parking lot with a Solar Powered Electric Vehicle Charging Station installed to promote use of energy efficient transportation. As funding becomes available and technology develops, additional innovative energy-efficient measures will be incorporated into the building. For example the proposed construction of the Solar Powered Electric Vehicle Charging.

  7. Geothermal resources assessment in Hawaii. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, D.M.

    1984-02-21

    The Hawaii Geothermal Resources Assessment Program was initiated in 1978. The preliminary phase of this effort identified 20 Potential Geothermal Resource Areas (PGRA's) using available geological, geochemical and geophysical data. The second phase of the Assessment Program undertook a series of field studies, utilizing a variety of geothermal exploration techniques, in an effort to confirm the presence of thermal anomalies in the identified PGRA's and, if confirmed, to more completely characterize them. A total of 15 PGRA's on four of the five major islands in the Hawaiian chain were subject to at least a preliminary field analysis. The remaining five were not considered to have sufficient resource potential to warrant study under the personnel and budget constraints of the program.

  8. Social Shaping in Danish Technology Assessment

    DEFF Research Database (Denmark)

    Hansen, Anne Grethe; Clausen, Christian

    2003-01-01

    The term ‘social shaping of technology’ has been used broadly as a response to techno-economic deterministic understandings of the relations between technology and society. Social shaping has brought together analysts from different backgrounds who share a common interest in the role of social...... and political action for technology change. The authors of this article suggest that the social shaping perspective draws on lessons from technology assessments of earlier decades, lessons about the role of technology debate, participation and democratic control. We suggest that these are important...... for technology policy initiatives at the beginning of the new millennium, as prerequisites for socially feasible and desirable technology development and innovation. On the basis of the Danish technology assessments of the 1980s, it is argued that technology assessments and the social shaping perspectives...

  9. Establishment of Health Technology Assessment in Iran

    Directory of Open Access Journals (Sweden)

    Shila Doaee

    2012-06-01

    Full Text Available Objective: Health Technology Assessment (HTA aims at informing healthcare policymakers, managers and practitioners of the "clinical consequences, but also the economic, ethical, and other social implications of the diffusion and use of a specific procedure or technique on medical practice". So considering the policy-oriented nature of HTA that calls for a close integration into the functioning and governance of health systems the present study focuses on executive processes and function of the HTA office of Iran.Materials and methods: Data of this review study were collected through documented sources and observations from 2007 to 2010.Results: Health Technology Assessment began its activities as a secretariat in the Deputy of Health in 2007 and it continues as a Health Technology Assessment Office at the Management of Health Technology Assessment, Standardization, and Tariff at the Deputy of curative affairs of MOHME in the beginning of 2010.14 Technology of modern medical equipment and 8 pharmaceutical medicine are assessed, Now many of measures for HTA establishment  such as cooperation National Institute of Health Research (NIHR, Holding scientific committee meetings, Establishing  the  Master's degree of  health technology assessment ,Building capacities for health technology assessment through education in major universities of the country.Conclusion: pay attention to health technology assessment, selection and application of proper technologies in the frameworks of policy-making and managerial strategies and make efforts to develop it with the support of the governmental in Iran is necessary.

  10. Technology for Online Portfolio Assessment Programs

    Science.gov (United States)

    Ferrara, Victoria M.

    2010-01-01

    Portfolio assessment is a valid and reliable method to assess experiential learning. Developing a fully online portfolio assessment program is neither easy nor inexpensive. The institution seeking to take its portfolio assessment program online must make a commitment to its students by offering the technologies most suited to meet students' needs.…

  11. NANA Geothermal Assessment Program Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Jay Hermanson

    2010-06-22

    In 2008, NANA Regional Corporation (NRC) assessed geothermal energy potential in the NANA region for both heat and/or electricity production. The Geothermal Assessment Project (GAP) was a systematic process that looked at community resources and the community's capacity and desire to develop these resources. In October 2007, the US Department of Energy's Tribal Energy Program awarded grant DE-FG36-07GO17075 to NRC for the GAP studies. Two moderately remote sites in the NANA region were judged to have the most potential for geothermal development: (1) Granite Mountain, about 40 miles south of Buckland, and (2) the Division Hot Springs area in the Purcell Mountains, about 40 miles south of Shungnak and Kobuk. Data were collected on-site at Granite Mountain Hot Springs in September 2009, and at Division Hot Springs in April 2010. Although both target geothermal areas could be further investigated with a variety of exploration techniques such as a remote sensing study, a soil geochemical study, or ground-based geophysical surveys, it was recommended that on-site or direct heat use development options are more attractive at this time, rather than investigations aimed more at electric power generation.

  12. Klickitat Cogeneration Project : Final Environmental Assessment.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration; Klickitat Energy Partners

    1994-09-01

    To meet BPA`s contractual obligation to supply electrical power to its customers, BPA proposes to acquire power generated by Klickitat Cogeneration Project. BPA has prepared an environmental assessment evaluating the proposed project. Based on the EA analysis, BPA`s proposed action is not a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act of 1969 for the following reasons: (1)it will not have a significant impact land use, upland vegetation, wetlands, water quality, geology, soils, public health and safety, visual quality, historical and cultural resources, recreation and socioeconomics, and (2) impacts to fisheries, wildlife resources, air quality, and noise will be temporary, minor, or sufficiently offset by mitigation. Therefore, the preparation of an environmental impact statement is not required and BPA is issuing this FONSI (Finding of No Significant Impact).

  13. NANA Wind Resource Assessment Program Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Jay Hermanson

    2010-09-23

    NANA Regional Corporation (NRC) of northwest Alaska is located in an area with abundant wind energy resources. In 2007, NRC was awarded grant DE-FG36-07GO17076 by the US Department of Energy's Tribal Energy Program for funding a Wind Resource Assessment Project (WRAP) for the NANA region. The NANA region, including Kotzebue Electric Association (KEA) and Alaska Village Electric Cooperative (AVEC) have been national leaders at developing, designing, building, and operating wind-diesel hybrid systems in Kotzebue (starting in 1996) and Selawik (2002). Promising sites for the development of new wind energy projects in the region have been identified by the WRAP, including Buckland, Deering, and the Kivalina/Red Dog Mine Port Area. Ambler, Shungnak, Kobuk, Kiana, Noorvik & Noatak were determined to have poor wind resources at sites in or very near each community. However, all five of these communities may have better wind resources atop hills or at sites with slightly higher elevations several miles away.

  14. Final Environmental Assessment Ohio River Islands National Wildlife Refuge Proposal

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — In this Final Environmental Assessment, the United States Fish and Wildlife Service describes various alternatives that could provide long-term protection to the...

  15. Life Cycle Assessment of Slurry Management Technologies

    DEFF Research Database (Denmark)

    Wesnæs, Marianne; Wenzel, Henrik; Petersen, Bjørn Molt

    This report contains the results of Life Cycle Assessments of two slurry management technologies - acidification and decentred incineration. The LCA foundation can be used by the contributing companies for evaluating the environmental sustainability of a specific technology from a holistic Life...... Cycle perspective. Through this the companies can evaluate the environmental benefits and disadvantages of introducing a specific technology for slurry management. From a societal perspective the results can contribute to a clarification of which slurry management technologies (or combination...

  16. Final report: U.S. competitive position in automotive technologies

    Energy Technology Data Exchange (ETDEWEB)

    Albert, Michael B.; Cheney, Margaret; Thomas, Patrick; Kroll, Peter

    2002-09-30

    Patent data are presented and analyzed to assess the U.S. competitive position in eleven advanced automotive technology categories, including automotive fuel cells, hydrogen storage, advanced batteries, hybrid electric vehicles and others. Inventive activity in most of the technologies is found to be growing at a rapid pace, particularly in advanced batteries, automotive fuel cells and ultracapacitors. The U.S. is the clear leader in automotive fuel cells, on-board hydrogen storage and light weight materials. Japan leads in advanced batteries, hybrid electric vehicles, ultracapacitors, and appears to be close to overtaking the U.S. in other areas of power electronics.

  17. Possible future environmental issues for fossil fuel technologies. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Attaway, L.D.

    1979-07-01

    The work reported here was carried out for the Department of Energy's Office of Fossil Energy to identify and assess 15 to 20 major environmental issues likely to affect the implementation of fossil energy technologies between 1985 and 2000. The energy technologies specifically addressed are: oil recovery and processing; gas recovery and processing; coal liquefaction; coal gasification (surface); in situ coal gasification; direct coal combustion; advanced power systems; magnetohydrodynamics; surface oil shale retorting; and true and modified in situ oil shale retorting. Environmental analysis of these technologies included, in addition to the main processing steps, the complete fuel cycle from resource extraction to end use. The 16 environmental issues identified as those most likely for future regulatory actions and the main features of, and the possible regulatory actions associated with, each are as follows: disposal of solid waste from coal conversion and combustion technologies; water consumption by coal and oil shale conversion technologies; siting of coal conversion facilities; the carbon dioxide greenhouse effect; emission of polycyclic organic matter (POM); impacts of outer continental shelf (OCS) oil development; emission of trace elements; groundwater contamination; liquefied natural gas (LNG), safety and environmental factors; underground coal mining - health and safety; fugitive emissions from coal gasification and liquefaction - health and safety; boomtown effects; emission of fine particulates from coal, oil and oil shale technologies; emission of radioactivity from the mining and conversion of coal; emission of nitrogn oxides; and land disturbance from surface mining. (LTN)

  18. Technological advances in radiotherapy for esophageal cancer

    Institute of Scientific and Technical Information of China (English)

    Milan; Vosmik; Jiri; Petera; Igor; Sirak; Miroslav; Hodek; Petr; Paluska; Jiri; Dolezal; Marcela; Kopacova

    2010-01-01

    Radiotherapy with concurrent chemotherapy and surgery represent the main treatment modalities in esophageal cancer.The goal of modern radiotherapy approaches,based on recent technological advances,is to minimize post-treatment complications by improving the gross tumor volume definition (positron emission tomography-based planning),reducing interfraction motion (image-guided radiotherapy) and intrafraction motion (respiratory-gated radiotherapy),and by better dose delivery to the precisely defined planning ...

  19. Automation of Technology for Cancer Research.

    Science.gov (United States)

    van der Ent, Wietske; Veneman, Wouter J; Groenewoud, Arwin; Chen, Lanpeng; Tulotta, Claudia; Hogendoorn, Pancras C W; Spaink, Herman P; Snaar-Jagalska, B Ewa

    2016-01-01

    Zebrafish embryos can be obtained for research purposes in large numbers at low cost and embryos develop externally in limited space, making them highly suitable for high-throughput cancer studies and drug screens. Non-invasive live imaging of various processes within the larvae is possible due to their transparency during development, and a multitude of available fluorescent transgenic reporter lines.To perform high-throughput studies, handling large amounts of embryos and larvae is required. With such high number of individuals, even minute tasks may become time-consuming and arduous. In this chapter, an overview is given of the developments in the automation of various steps of large scale zebrafish cancer research for discovering important cancer pathways and drugs for the treatment of human disease. The focus lies on various tools developed for cancer cell implantation, embryo handling and sorting, microfluidic systems for imaging and drug treatment, and image acquisition and analysis. Examples will be given of employment of these technologies within the fields of toxicology research and cancer research.

  20. The Oviduct and Serous Cancer Risk Assessment

    Science.gov (United States)

    2015-10-01

    all the pathological and immunological hallmarks of human high-grade serous cancer , such as gain of p53, EZH2 and MUC4 expression (Figure 2a) 15 26...59 60 For Peer Review Figure 3. . Molecular correlates of progression from STIC to invasive cancer . a. Left, Histology of the sections used...1 AWARD NUMBER: W81XWH-14-1-0504 TITLE: The Oviduct and Serous Cancer Risk Assessment PRINCIPAL INVESTIGATOR: Christopher P. Crum, MD

  1. Carbon Capture: A Technology Assessment

    Science.gov (United States)

    2013-10-21

    monoethanolamine (MEA) and ammonia ; pre- combustion capture (also via chemical solvents) from the synthesis gas produced in an integrated coal gasification...71 D. Heaven et al., “ Synthesis Gas Purification in Gasification to Ammonia /Urea Plants,” Gasification Technologies...32 Ammonia -Based Capture Processes

  2. Civil Engineering Technology Needs Assessment.

    Science.gov (United States)

    Oakland Community Coll., Farmington, MI. Office of Institutional Planning and Analysis.

    In 1991, a study was conducted by Oakland Community College (OCC) to evaluate the need for a proposed Civil Engineering Technology program. An initial examination of the literature focused on industry needs and the job market for civil engineering technicians. In order to gather information on local area employers' hiring practices and needs, a…

  3. Wireless technology for ABC Assessment

    DEFF Research Database (Denmark)

    Kristensen, Margit; Kyng, Morten; Christensen, Erika Frischknecht;

      In medical emergency service (EMS) the ABC status (Airway-Breathing-Circulation) of victims is essential in the decision making process regarding prioritizing and treatment. Today's use of information technology does, however, not inform directly about "A" and "B". The parameters are evaluated ...

  4. Economic assessment of advanced flue gas desulfurization processes. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Bierman, G. R.; May, E. H.; Mirabelli, R. E.; Pow, C. N.; Scardino, C.; Wan, E. I.

    1981-09-01

    This report presents the results of a project sponsored by the Morgantown Energy Technology Center (METC). The purpose of the study was to perform an economic and market assessment of advanced flue gas desulfurization (FGD) processes for application to coal-fired electric utility plants. The time period considered in the study is 1981 through 1990, and costs are reported in 1980 dollars. The task was divided into the following four subtasks: (1) determine the factors affecting FGD cost evaluations; (2) select FGD processes to be cost-analyzed; (3) define the future electric utility FGD system market; and (4) perform cost analyses for the selected FGD processes. The study was initiated in September 1979, and separate reports were prepared for the first two subtasks. The results of the latter two subtasks appear only in this final reprot, since the end-date of those subtasks coincided with the end-date of the overall task. The Subtask 1 report, Criteria and Methods for Performing FGD Cost Evaluations, was completed in October 1980. A slightly modified and condensed version of that report appears as appendix B to this report. The Subtask 2 report, FGD Candidate Process Selection, was completed in January 1981, and the principal outputs of that subtask appear in Appendices C and D to this report.

  5. Single Cell Functional Proteomics for Monitoring Immune Response in Cancer Therapy: Technology, Methods and Applications

    Directory of Open Access Journals (Sweden)

    Chao eMa

    2013-05-01

    Full Text Available In the past decade, significant progresses have taken place in the field of cancer immunotherapeutics, which are being developed for most human cancers. New immunotherapeutics, such as Ipilimumab (anti-CTLA-4, have been approved for clinical treatment; cell-based immunotherapies such as adoptive cell transfer (ACT have either passed the final stage of human studies (i.e., sipuleucel-T for the treatment of selected neoplastic malignancies or reached the stage of phase II/III clinical trials. Immunotherapetics has become a sophisticated field. Multimodal therapeutic regimens comprising several functional modules (up to 5 in the case of ACT have been developed to provide focused therapeutic responses with improved efficacy and reduced side-effects. However, a major challenge remains: the lack of effective and clinically-applicable immune assessment methods. Due to the complexity of antitumor immune responses within patients, it is difficult to provide comprehensive assessment of therapeutic efficacy and mechanism. To address this challenge, new technologies have been developed to directly profile the cellular immune functions and the functional heterogeneity. With the goal to measure the functional proteomics of single immune cells, these technologies are informative, sensitive, high-throughput and highly-multiplex. They have been used to uncover new knowledge of cellular immune functions and have be utilized for rapid, informative, and longitudinal monitoring of immune response in clinical anti-cancer treatment. In addition, new computational tools are required to integrate high dimensional data sets generated from the comprehensive, single-cell level measurements of patient’s immune responses to guide accurate and definitive diagnostic decision. These single-cell immune function assessment tools will likely contribute to new understanding of therapy mechanism, pre-treatment stratification of patients and ongoing therapeutic monitoring and

  6. Assessing medical technologies in development - A new paradigm of medical technology assessment

    NARCIS (Netherlands)

    Hummel, MJM; van Rossum, W; Verkerke, GJ; Rakhorst, G

    2000-01-01

    Objective: Our study aims to provide a practical contribution to the field of medical technology assessment within a new paradigm. This paradigm indicates the need for more comprehensive technology assessments in the development stage of a new technology. Method: We introduce a method, based on Saat

  7. Geriatric assessment in elderly patients with prostate cancer.

    Science.gov (United States)

    Terret, Catherine; Albrand, Gilles; Droz, Jean Pierre

    2004-03-01

    As a result of demographic evolution, oncologists will treat more and more elderly patients with prostate cancer. Aging is frequently associated with the coexistence of several medical complications that can increase the complexity of cancer treatment decision-making. Unfortunately, clinical oncologists need to be more familiar with the multidimensional assessment of elderly patients. To acquire this skill, we implemented a multidimensional geriatric assessment program at our cancer center. This instrument prospectively assessed 60 elderly patients with prostate cancer. Herein, we describe geriatric aspects detected in our patient sample and report treatment options proposed to elderly patients with prostate cancer at different disease stages. The minimal comprehensive geriatric assessment (mini-CGA) procedure revealed that 66% of our patient population was dependent in one or more of the Katz Activities of Daily Living and 87% were dependent in 1 or more of the Lawton Instrumental Activities of Daily Living; all patients had significant comorbidity according to the Cumulative Illness Rating Scale-Geriatrics, 75% having at least one severe comorbidity. We identified 19 cases of drug interaction. We also observed that half of these patients had a risk of falling and some physical disability; 45% had cognitive disorders requiring more investigation; one third had depressive symptoms. Finally, 65% of the patients were either malnourished or at risk of malnutrition. Many of these problems were unknown before the mini-CGA processing and may interfere with cancer and cancer treatment. Thus, the correct management of elderly patients with cancer requires comprehensive geriatric assessment as well as relevant disease staging at diagnosis. This approach will help us to propose the most appropriate treatment with the main aim of preserving quality of life.

  8. The internationalization of health technology assessment.

    Science.gov (United States)

    Menon, D; Marshall, D

    1996-01-01

    Health technology assessment as a formalized set of activities has a relatively short history. At its current stage of development, it is clear that it has global dimensions and impact. In this paper we review the history of health technology assessment, its development as a form of health services research, and its "institutionalization." We then identify the reasons for its internationalization, review current international initiatives, and propose actions to be taken to improve cooperation among countries.

  9. Biological Environmental Sampling Technologies Assessment

    Science.gov (United States)

    2015-12-01

    Nano Intelligent Detection System (NIDS) ........................5 2.3 BBI Detection BWA Integrated Multiplex Assay and Sampling System (IMASS...the samples can be collected ft2 Informational only Not provided N/A N/A Info only GRAND TOTAL 920 5 2.2 ANP Technologies Nano Intelligent ...from all types of surfaces and absorb unknown liquids. The Aklus Shield system can also be used to sample debris, soil, or vegetation . For this

  10. Rapid Technology Assessment Framework for Land Logistics

    Science.gov (United States)

    2015-03-01

    navigation technology) becomes dead weight; reverse logistic chain may be required to bring the equipment back • Local systems and networks will...UNCLASSIFIED UNCLASSIFIED Rapid Technology Assessment Framework for Land logistics Ksenia Ivanova and Guy Edward Gallasch...in this document focuses on military Land logistics applications, although similar principles can be applied to other military domains

  11. Automatization of Student Assessment Using Multimedia Technology.

    Science.gov (United States)

    Taniar, David; Rahayu, Wenny

    Most use of multimedia technology in teaching and learning to date has emphasized the teaching aspect only. An application of multimedia in examinations has been neglected. This paper addresses how multimedia technology can be applied to the automatization of assessment, by proposing a prototype of a multimedia question bank, which is able to…

  12. Final Report on Pilot Studies / Final Report on Classroom Research with STEM and TESL Assessment

    DEFF Research Database (Denmark)

    Biel, Carmen; Wake, Jo Dugstad; Hesse, Friedrich

    This Deliverable is the final report on pilot studies within the NEXT-TELL project (D6.7) and furthermore comprises the Deliverable on Classroom Research with STEM and TESL Assessment (D2.9) in order to avoid redundancies between those two Deliverables.......This Deliverable is the final report on pilot studies within the NEXT-TELL project (D6.7) and furthermore comprises the Deliverable on Classroom Research with STEM and TESL Assessment (D2.9) in order to avoid redundancies between those two Deliverables....

  13. Assessment and Learning Technologies: An Overview

    Science.gov (United States)

    Farrell, Treasa; Rushby, Nick

    2016-01-01

    Assessment pervades the learning process. This paper provides an overview of the application of technology to support and enhance diagnostic, formative and summative assessment. The focus is on examining how it can replace what already exists, improve the functionality, catalyse a redesign of the process and in some circumstances, make possible…

  14. An environmental assessment system for environmental technologies

    DEFF Research Database (Denmark)

    Clavreul, Julie; Baumeister, Hubert; Christensen, Thomas Højlund;

    2014-01-01

    A new model for the environmental assessment of environmental technologies, EASETECH, has been developed. The primary aim of EASETECH is to perform life-cycle assessment (LCA) of complex systems handling heterogeneous material flows. The objectives of this paper are to describe the EASETECH...

  15. The Clinical Proteomic Technologies for Cancer | Antibody Portal

    Science.gov (United States)

    An objective of the Reagents and Resources component of NCI's Clinical Proteomic Technologies for Cancer Initiative is to generate highly characterized monoclonal antibodies to human proteins associated with cancer.

  16. Renal Cancer Biomarkers | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The National Cancer Institute's Laboratory of Proteomics and Analytical Technologies is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize diagnostic, therapeutic and prognostic cancer biomarkers from clinical specimens.

  17. 75 FR 62133 - Notice of Availability of Final Environmental Assessment (FINAL EA) and a Finding of No...

    Science.gov (United States)

    2010-10-07

    ... Availability of Final Environmental Assessment (FINAL EA) and a Finding of No Significant Impact (FONSI) for... Environmental Assessment (FINAL EA) for Land Purchase, Access Road Construction and Access Tunnel Construction... HUMAN SERVICES Centers for Disease Control and Prevention Notice of Availability of Final...

  18. The social function of technology assessment

    Science.gov (United States)

    Huddle, F. P.

    1972-01-01

    The problem of preserving the uneasy balance between a dynamic society and the equilibrium of man-environment society is discussed. Four sets of activities involved in technology assessment are considered: (1) Technology forecasting is necessary to warn of future dangers and opportunities, for effective timing, and to identify tradeoffs and alternatives. But forecasting is also chancy at best. (2) Social indicators need to be developed for the characterization of social status and measurement of social progress, as well as a better understanding of social needs. (3) With respect to technology assessment, the conflict between profitable directions of innovations and socially desirable directions is described, and a systematic way is needed to determine in advance what is technologically feasible to meet social needs. (4) National goals with respect to scientific and technological developments are also required.

  19. Health technology assessment. Evaluation of biomedical innovative technologies.

    Science.gov (United States)

    Turchetti, Giuseppe; Spadoni, Enza; Geisler, Eliezer Elie

    2010-01-01

    This article describes health technology assessment (HTA) as an evaluation tool that applies systematic methods of inquiry to the generation and use of health technologies and new products. The focus of this article is on the contributions of HTA to the management of the new product development effort in the biomedical organization. Critical success factors (CSFs) are listed, and their role in assessing success is defined and explained. One of the conclusions of this article is that HTA is a powerful tool for managers in the biomedical sector, allowing them to better manage their innovation effort in their continuing struggle for competitiveness and survival.

  20. Coal-fueled diesel: Technology development: Final report

    Energy Technology Data Exchange (ETDEWEB)

    Leonard, G.; Hsu, B.; Flynn, P.

    1989-03-01

    This project consisted of four tasks: (1) to determine if CWM could be ignited and burned rapidly enough for operation in a 1000-rpm diesel engine, (2) to demonstrate that a durable CWM-fueled engine could in principle be developed, (3) to assess current emissions control technology to determine the feasibility of cleaning the exhaust of a CWM-fueled diesel locomotive, and (4) to conduct an economic analysis to determine the attractiveness of powering US locomotives with CWM. 34 refs., 125 figs., 28 tabs.

  1. MIST Final Report: Multi-sensor Imaging Science and Technology

    Energy Technology Data Exchange (ETDEWEB)

    Lind, Michael A.; Medvick, Patricia A.; Foley, Michael G.; Foote, Harlan P.; Heasler, Patrick G.; Thompson, Sandra E.; Nuffer, Lisa L.; Mackey, Patrick S.; Barr, Jonathan L.; Renholds, Andrea S.

    2008-03-15

    The Multi-sensor Imaging Science and Technology (MIST) program was undertaken to advance exploitation tools for Long Wavelength Infra Red (LWIR) hyper-spectral imaging (HSI) analysis as applied to the discovery and quantification of nuclear proliferation signatures. The program focused on mitigating LWIR image background clutter to ease the analyst burden and enable a) faster more accurate analysis of large volumes of high clutter data, b) greater detection sensitivity of nuclear proliferation signatures (primarily released gasses) , and c) quantify confidence estimates of the signature materials detected. To this end the program investigated fundamental limits and logical modifications of the more traditional statistical discovery and analysis tools applied to hyperspectral imaging and other disciplines, developed and tested new software incorporating advanced mathematical tools and physics based analysis, and demonstrated the strength and weaknesses of the new codes on relevant hyperspectral data sets from various campaigns. This final report describes the content of the program and the outlines the significant results.

  2. Health technology assessment and thyroid surgery.

    Science.gov (United States)

    Lucchini, R; Sanguinetti, A; Monacelli, M; Triola, R; Avenia, S; Conti, C; Santoprete, S; Avenia, N

    2013-01-01

    The growth of technological innovation, the request for assistance, the rising patient's expectations and the interest of the industry have led to a rise in the cost of health care systems. In this context the role of the National Health System is not to delay the development or adoption of new technologies, but rather to drive the development selecting priorities and promoting its use. Health Technology Assessment (HTA) is a multidisciplinary and multidimensional approach for analyzing the medical-clinical, social, organizational, economic, ethical and legal implications of a technology (devices, drugs, procedures) through the assessment of multiple parameters such as effectiveness, safety, costs of the social and organizational impact. A health technology assessment is a comprehensive, systematic evaluation of the prerequisites for estimating the consequences of using health technology. Main characteristic of HTA is that the problem is tackled using an approach focused on four main elements: - technology; - patient; - organization; - economy. The authors have applied the HTA method for the analysis of the ultrasonic focus dissector on thyroid surgery. They compared the cost of the surgical procedure using the ultrasonic dissector and without it in a case study of 440 patients who underwent thyroidectomy.

  3. Plan for advanced microelectronics processing technology application. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Goland, A.N.

    1990-10-01

    The ultimate objective of the tasks described in the research agreement was to identify resources primarily, but not exclusively, within New York State that are available for the development of a Center for Advanced Microelectronics Processing (CAMP). Identification of those resources would enable Brookhaven National Laboratory to prepare a program plan for the CAMP. In order to achieve the stated goal, the principal investigators undertook to meet the key personnel in relevant NYS industrial and academic organizations to discuss the potential for economic development that could accompany such a Center and to gauge the extent of participation that could be expected from each interested party. Integrated of these discussions was to be achieved through a workshop convened in the summer of 1990. The culmination of this workshop was to be a report (the final report) outlining a plan for implementing a Center in the state. As events unfolded, it became possible to identify the elements of a major center for x-ray lithography on Lone Island at Brookhaven National Laboratory. The principal investigators were than advised to substitute a working document based upon that concept in place of a report based upon the more general CAMP workshop originally envisioned. Following that suggestion from the New York State Science and Technology Foundation, the principals established a working group consisting of representatives of the Grumman Corporation, Columbia University, the State University of New York at Stony Brook, and Brookhaven National Laboratory. Regular meetings and additional communications between these collaborators have produced a preproposal that constitutes the main body of the final report required by the contract. Other components of this final report include the interim report and a brief description of the activities which followed the establishment of the X-ray Lithography Center working group.

  4. Health Technology Assessment and patient safety

    Directory of Open Access Journals (Sweden)

    Andrew Mulcahy

    2005-12-01

    Full Text Available

    Health Technology Assessment (HTA is a process used to evaluate the clinical effectiveness and costeffectiveness of health technologies by a systematic review of clinical, economic, and utilization research.

    Despite widespread investment in patient safety technologies in the U.K., U.S., and elsewhere, little HTA has been done to establish the clinical or cost-effectiveness of these technologies. The HTA and patient safety literature suggests there are four categories of patient safety HTA, including HTA for existing safety technologies, underutilized safety technologies, emerging safety technologies, as well as safety aspects of technologies with a non-safety primary purpose.

    Recent HTA and other research, including a 2002 evidencebased evaluation of patient safety technologies from the U.S. Agency for Health Research and Quality, provide an important foundation for a more comprehensive approach to patient safety HTA. However, HTA programs must address prioritization, methodology, and dissemination challenges introduced by patient safety technologies before significant progress can Te made.

  5. Challenges for relative effectiveness assessment and early access of cancer immunotherapies in Europe

    Directory of Open Access Journals (Sweden)

    Mira Pavlovic

    2016-11-01

    Full Text Available Clinical endpoints relevant for relative effectiveness assessment (REA reflect how patients feel, function, or survive. Outcome data requested by Health Technology Assessment (HTA bodies in Europe to support reimbursement of an anticancer drug are based on final endpoints coming from completed comparative phase 3 trials; overall survival improvement is the preferred criterion for the demonstration of the patient benefit in this field.Recent arrival of new treatments that target identified functional genetic mutations (targeted therapies or PD-1/PD-L1,2 axis (immunotherapies and their combinations have profoundly changed treatment strategies in cancers as they considerably improve patient survival, but also raise new challenges in REA and decision making process in Europe as compared to the REA of classical chemotherapies. In addition, recent regulatory initiatives to support accelerated clinical development and approval of innovative cancer immunotherapies based on non-final endpoints, such as Priority Medicines (PRIME through the European Medicines Agency (EMA, represent an additional challenge for HTA bodies and decision makers.In order to support adequate data generation for REA of anticancer drugs and especially for drugs candidates for accelerated assessment and early access to market, a close and open dialogue of all stakeholders involved in development of such drugs is crucial

  6. Challenges for Relative Effectiveness Assessment and Early Access of Cancer Immunotherapies in Europe.

    Science.gov (United States)

    Pavlovic, Mira

    2016-01-01

    Clinical endpoints relevant for relative effectiveness assessment (REA) reflect how patients feel, function, or survive. Outcome data requested by health technology assessment (HTA) bodies in Europe to support reimbursement of an anticancer drug are based on final endpoints coming from completed comparative phase 3 trials; overall survival improvement is the preferred criterion for the demonstration of the patient benefit in this field. Recent arrival of new treatments that target identified functional genetic mutations ("targeted therapies") or PD-1/PD-L1,2 axis ("immunotherapies") and their combinations have profoundly changed treatment strategies in cancers as they considerably improve patient survival, but also raise new challenges in REA and decision-making process in Europe as compared to the REA of "classical" chemotherapies. In addition, recent regulatory initiatives to support accelerated clinical development and approval of innovative cancer immunotherapies based on non-final endpoints, such as priority medicines through the European Medicines Agency, represent an additional challenge for HTA bodies and decision makers. In order to support adequate data generation for REA of anticancer drugs and especially for drugs candidates for accelerated assessment and early access to market, a close and open dialog of all stakeholders involved in development of such drugs is crucial.

  7. Independent Assessment of Technology Characterizations to Support the Biomass Program Annual State-of-Technology Assessments

    Energy Technology Data Exchange (ETDEWEB)

    Yeh, B.

    2011-03-01

    This report discusses an investigation that addressed two thermochemical conversion pathways for the production of liquid fuels and addressed the steps to the process, the technology providers, a method for determining the state of technology and a tool to continuously assess the state of technology. This report summarizes the findings of the investigation as well as recommendations for improvements for future studies.

  8. Status and assessment of photovoltaic technologies

    Science.gov (United States)

    Kazmerski, L. L.

    The history and status of the current photovoltaic technologies are reviewed and evaluated. The problems and strengths of single-crystal, polycrystalline, and amorphous technologies are discussed, compared, and assessed. Single-junction and multiple-junction or tandem cell configurations are evaluated for performance, processing, and engineering criteria. Some emphasis is placed on the emerging thin film options for low cost terrestrial applications. The basic photovoltaic system building block, the solar cell, is discussed along with important module developments and problems. Future technology and research directions are provided for materials, cells, and modules.

  9. Status and assessment of photovoltaic technologies

    Energy Technology Data Exchange (ETDEWEB)

    Kazmerski, L.L. (Solar Energy Research Inst., Golden, CO (USA))

    1989-01-01

    The history and status of the current photovoltaic technologies are reviewed and evaluated. The problems and strengths of single-crystal, polycrystalline, and amorphous technologies are discussed, compared and assessed. Single-junction and multiple-junction or tandem cell configurations are evaluated for performance, processing, and engineering criteria. Some emphasis is placed on the emerging thin film options for low cost terrestrial applications. Discussions centre around the basic photovoltaic system building block, the solar cell, but important module developments and problems are cited. Future technology and research directions are provided for materials, cells, and modules. (author).

  10. Final Report - DOE Center for Laser Imaging and Cancer Diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Alfano, Robert R.; Koutcher, Jason A.

    2002-10-31

    This Final Report summarizes the significant progress made by the researchers, students and staff of the Center for Laser Imaging and Cancer Diagnostics (CLICD) from January 1998 through May 2002. During this period, the Center supported several projects. Most projects were proposed initially, some were added subsequently as their relevance and importance to the DOE mission became evident. DOE support has been leveraged to obtain continuing funding for some projects. Leveraged funds come from various sources, including NIH, Army, NSF and the Air Force. The goal of the Center was to develop laser-based instruments for use in the detection and diagnosis of major diseases, with an emphasis on detection and diagnosis of various cancers. Each of the supported projects is a collaborative effort between physicists and laser scientists and the City College of New York and noted physicians, surgeons, pathologists, and biologists located at medical centers in the Metropolitan area. The participating institutions were: City College of New York Institute for Ultrafast Lasers and Spectroscopy, Hackensack University Medical Center, Lawrence Livermore National Laboratory, Memorial Sloan Kettering Cancer Center, and New York Eye and Ear Institute. Each of the projects funded by the Center is grouped into one of four research categories: a) Disease Detection, b) Non-Disease Applications, c) New Diagnostic Tools, and, d) Education, Training, Outreach and Dissemination. The progress achieved by the multidisciplinary teams was reported in 51 publications and 32 presentations at major national conferences. Also, one U.S. patent was obtained and six U.S. patent applications have been filed for innovations resulting from the projects sponsored by the Center.

  11. Broadband Satellite Technologies and Markets Assessed

    Science.gov (United States)

    Wallett, Thomas M.

    1999-01-01

    The current usage of broadband (data rate greater than 64 kilobits per second (kbs)) for multimedia network computer applications is increasing, and the need for network communications technologies and systems to support this use is also growing. Satellite technology will likely be an important part of the National Information Infrastructure (NII) and the Global Information Infrastructure (GII) in the next decade. Several candidate communications technologies that may be used to carry a portion of the increased data traffic have been reviewed, and estimates of the future demand for satellite capacity have been made. A study was conducted by the NASA Lewis Research Center to assess the satellite addressable markets for broadband applications. This study effort included four specific milestones: (1) assess the changing nature of broadband applications and their usage, (2) assess broadband satellite and terrestrial technologies, (3) estimate the size of the global satellite addressable market from 2000 to 2010, and (4) identify how the impact of future technology developments could increase the utility of satellite-based transport to serve this market.

  12. Interactive Technology Assessment in the Real World

    NARCIS (Netherlands)

    Marris, Claire; Joly, Pierre-Benoit; Rip, Arie

    2008-01-01

    Participatory Technology Assessment (pTA) initiatives have usually been analyzed as if they existed in a social and political vacuum. This article analyzes the linkages that occur, in both directions, between the microcosm set up by a pTA exercise and the real world outside. This dual-dynamics persp

  13. Expanding the applicability of Heallth Technology Assessments

    DEFF Research Database (Denmark)

    Draborg, Eva; Hansen, Helle Ploug

    2012-01-01

    The objective of the presentation is to expand the foundations of input into policy decision making relying on health technology assessments (HTA). HTAs are primarily based on systematic reviews (SR) and thereby mostly on randomized controlled trials (RCT). RCTs can be distinguished on a continuu...

  14. Interactive technology assessment and wide reflective equilibrium.

    NARCIS (Netherlands)

    Reuzel, R.P.B.; Wilt, G.J. van der; Have, H.A.M.J. ten; Vries Robbé, P.F. de

    2001-01-01

    Interactive technology assessment (iTA) provides an answer to the ethical problem of normative bias in evaluation research. This normative bias develops when relevant perspectives on the evaluand (the thing being evaluated) are neglected. In iTA this bias is overcome by incorporating different persp

  15. Teacher Learning of Technology Enhanced Formative Assessment

    Science.gov (United States)

    Feldman, Allan; Capobianco, Brenda M.

    2008-01-01

    This study examined the integration of technology enhanced formative assessment (FA) into teachers' practice. Participants were high school physics teachers interested in improving their use of a classroom response system (CRS) to promote FA. Data were collected using interviews, direct classroom observations, and collaborative discussions. The…

  16. Biomass Gasification Technology Assessment: Consolidated Report

    Energy Technology Data Exchange (ETDEWEB)

    Worley, M.; Yale, J.

    2012-11-01

    Harris Group Inc. (HGI) was commissioned by the National Renewable Energy Laboratory to assess gasification and tar reforming technologies. Specifically, the assessments focused on gasification and tar reforming technologies that are capable of producing a syngas suitable for further treatment and conversion to liquid fuels. HGI gathered sufficient information to analyze three gasification and tar reforming systems. This report summarizes the equipment, general arrangement of the equipment, operating characteristics, and operating severity for each technology. The order of magnitude capital cost estimates are supported by a basis-of-estimate write-up, which is also included in this report. The report also includes Microsoft Excel workbook models, which can be used to design and price the systems. The models can be used to analyze various operating capacities and pressures. Each model produces a material balance, equipment list, capital cost estimate, equipment drawings and preliminary general arrangement drawings. Example outputs of each model are included in the Appendices.

  17. Sustainability assessment of advanced wastewater treatment technologies.

    Science.gov (United States)

    Høibye, L; Clauson-Kaas, J; Wenzel, H; Larsen, H F; Jacobsen, B N; Dalgaard, O

    2008-01-01

    As a consequence of the EU Water Framework Directive more focus is now on discharges of hazardous substances from wastewater treatment plants and sewers. Thus, many municipalities in Denmark may have to adopt to future advanced treatment technologies. This paper describes a holistic assessment, which includes technical, economical and environmental aspects. The technical and economical assessment is performed on 5 advanced treatment technologies: sand filtration, ozone treatment, UV exclusively for disinfection of pathogenic microorganisms, membrane bioreactor (MBR) and UV in combination with advanced oxidation. The technical assessment is based on 12 hazardous substances comprising heavy metals, organic pollutants, endocrine disruptors as well as pathogenic microorganisms. The environmental assessment is performed by life cycle assessment (LCA) comprising 9 of the specific hazardous substances and three advanced treatment methods; sand filtration, ozone treatment and MBR. The technical and economic assessment showed that UV solely for disinfection purposes or ozone treatment is the most advantageous advanced treatment methods if the demands are restricted to pathogenic microorganisms. In terms of sustainability, sand filtration is the most advantageous method based on the technical and environmental assessment due to the low energy consumption and high efficiency with regards to removal of heavy metals.

  18. Technology Assessment and Roadmap for the Emergency Radiation Dose Assessment Program

    Energy Technology Data Exchange (ETDEWEB)

    Turteltaub, K W; Hartman-Siantar, C; Easterly, C; Blakely, W

    2005-10-03

    A Joint Interagency Working Group (JIWG) under the auspices of the Department of Homeland Security Office of Research and Development conducted a technology assessment of emergency radiological dose assessment capabilities as part of the overall need for rapid emergency medical response in the event of a radiological terrorist event in the United States. The goal of the evaluation is to identify gaps and recommend general research and development needs to better prepare the Country for mitigating the effects of such an event. Given the capabilities and roles for responding to a radiological event extend across many agencies, a consensus of gaps and suggested development plans was a major goal of this evaluation and road-mapping effort. The working group consisted of experts representing the Departments of Homeland Security, Health and Human Services (Centers for Disease Control and the National Institutes of Health), Food and Drug Administration, Department of Defense and the Department of Energy's National Laboratories (see appendix A for participants). The specific goals of this Technology Assessment and Roadmap were to: (1) Describe the general context for deployment of emergency radiation dose assessment tools following terrorist use of a radiological or nuclear device; (2) Assess current and emerging dose assessment technologies; and (3) Put forward a consensus high-level technology roadmap for interagency research and development in this area. This report provides a summary of the consensus of needs, gaps and recommendations for a research program in the area of radiation dosimetry for early response, followed by a summary of the technologies available and on the near-term horizon. We then present a roadmap for a research program to bring present and emerging near-term technologies to bear on the gaps in radiation dose assessment and triage. Finally we present detailed supporting discussion on the nature of the threats we considered, the status of

  19. Early phase Technology Assessment of nanotechnology in oncology.

    Science.gov (United States)

    Retèl, Valesca P; Hummel, Marjan J M; van Harten, Willem H

    2008-01-01

    To perform early Technology Assessment (TA) of nanotechnology in oncology. The possibilities of nanotechnology for detection (imaging), diagnosis and treatment of cancer are subject of different research programs where major investments are concerned. As a range of bio- nanotechnologies is expected to enter the oncology field it is relevant to consider the various aspects involved in especially early TA. This article provides two cases of early assessment of (predecessors of) nanotechnologies: Microarray Analysis and Photodynamic Therapy implementation, which methodology can be extrapolated to other nanotechnologies in oncology. Constructive Technology Assessment (CTA) is used for the introduction of technologies that are still in a dynamic phase of development or in an early stage of diffusion. The selection of studied aspects in CTA is based on: clinical aspects (safety, efficacy, and effectiveness), economic (cost-effectiveness), patient related (QoL, ethical/juridical and psychosocial), organizational aspects (diffusion and adoption) and scenario drafting. The features of the technology and the phase of implementation are decisive for choices and timing of the specific aspects to be studied. A framework was drafted to decide on the relevant aspects. In the first case, early implementation of Microarray Analysis; clinical effectiveness, logistics, patient centeredness and scenario drafting were given priority. Related to the diffusion-phase of Photodynamic Therapy however other aspects were evaluated, such as early cost-effectiveness analysis for possible reimbursement. Often CTA will result in a mixed method design. Especially scenario drafting is a powerful instrument to predict possible developments that can be anticipated upon in the assessment. CTA is appropriate for the study of early implementation of new technologies in oncology. In early TA small series often necessitate a mix of quantitative and qualitative methods. The features of nanotechnology

  20. Constructive Technology Assessment for HIT development

    DEFF Research Database (Denmark)

    Høstgaard, Anna Marie Balling; Bertelsen, Pernille; Petersen, Lone Stub

    2013-01-01

    -users. The CTA methodology is based on a Socio-technical understanding of technological development as an open ended, emergent process. The CTA was used during the EHR development process in the Region of North Jutland where it proved successful inproviding learning and feedback between all relevant groups...... in HIT development. A new evaluation methodology, including an analytical framework, has been developed specifically for HIT development: Constructive Technology Assessment (CTA) for HIT. It offers solutions to both the problems associated with summative technology evaluation and a way to involve end......Experience and time has shown a need for new evaluation methods for evaluating Health Information Technology (HIT), as summative evaluation methods fail to accommodate the rapid and constant changes in HIT over time and to involve end-users, which has been recognized as an important success factor...

  1. Assessment of Sensor Technologies for Advanced Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Korsah, Kofi [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ramuhalli, Pradeep [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Vlim, R. [Argonne National Lab. (ANL), Argonne, IL (United States); Kisner, Roger A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Britton, Jr, Charles L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wootan, D. W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Anheier, Jr, N. C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Diaz, A. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hirt, E. H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Chien, H. T. [Argonne National Lab. (ANL), Argonne, IL (United States); Sheen, S. [Argonne National Lab. (ANL), Argonne, IL (United States); Bakhtiari, Sasan [Argonne National Lab. (ANL), Argonne, IL (United States); Gopalsami, S. [Argonne National Lab. (ANL), Argonne, IL (United States); Heifetz, A. [Argonne National Lab. (ANL), Argonne, IL (United States); Tam, S. W. [Argonne National Lab. (ANL), Argonne, IL (United States); Park, Y. [Argonne National Lab. (ANL), Argonne, IL (United States); Upadhyaya, B. R. [Univ. of Tennessee, Knoxville, TN (United States); Stanford, A. [Univ. of Tennessee, Knoxville, TN (United States)

    2016-10-01

    Sensors and measurement technologies provide information on processes, support operations and provide indications of component health. They are therefore crucial to plant operations and to commercialization of advanced reactors (AdvRx). This report, developed by a three-laboratory team consisting of Argonne National Laboratory (ANL), Oak Ridge National Laboratory (ORNL) and Pacific Northwest National Laboratory (PNNL), provides an assessment of sensor technologies and a determination of measurement needs for AdvRx. It provides the technical basis for identifying and prioritizing research targets within the instrumentation and control (I&C) Technology Area under the Department of Energy’s (DOE’s) Advanced Reactor Technology (ART) program and contributes to the design and implementation of AdvRx concepts.

  2. Sustainability assessment of advanced wastewater treatment technologies

    DEFF Research Database (Denmark)

    Høibye, Linda; Clauson-Kaas, Jes; Wenzel, Henrik

    2007-01-01

    As a consequence of the EU Water Framwork Directive, more focus is now on discharges of hazardous substances from wastewater treatment plants and sewers. Thus, many municipalities in Denmark may have to adopt to future advenced treatment technologies. This paper describes a holistic assessment......, which includes technical, economic and environmental aspects. The technical and economic assessment is performed on 5 advanced treatment technologies: sand filtration, ozone treatment, UV exclusively for disinfection of pathogenic microorganisms, Membrane Bioreactor (MBR), and UV in combination...... and three advanced treatment methods: sand filtration, ozone treatment and MBR. The technical and economic assessment showed that UV solely for disinfection purposes or ozone treatment are the most advantageous advanved treatment methods if the demands are restricted to pathogenic microorganisms. In terms...

  3. Assessment of international air pollution prevention and control technology. Volume 2. Technical report. Report to Congress under CAA amendments of 1990, section 901(e) public law 104-549. Final report, December 1993-December 1995

    Energy Technology Data Exchange (ETDEWEB)

    Burklin, C.; Gundappa, M.; Jones, D.

    1996-08-01

    The report gives results of a study that identifies new and innovative air pollution prevention and/or control technologies, of selected industrialized countries, that are not currently used extensively in the U.S. The study addressed technologies that prevent or control the emissions of the pollutants from each of four sources of air pollution: (1) Urban emissions--ozone precursors to include nitrogen oxides (NOx), volatile organic componds (VOCs), particulate matter (PM), and air toxics; (2) Motor vehicle emissions--NOx, carbon monoxide (CO), and PM; (3) Toxic air emissions--any one of the 189 compounds on the list of hazardous air pollutants (HAPs) in the 1990 CAAA (Title III); and (4) Acid deposition--NOx, sulfur oxides (SOx), and, to a lesser extent, VOCs. The report describes the approach taken to identify potentially useful technologies, gives results of the technology search and evaluation, and describes the selected technologies.

  4. Assessment of international air pollution prevention and control technology. Volume 1. Executive summary. Report to Congress under CAA amendments of 1990, section 901(e) public law 101-549. Final report, December 1993-December 1995

    Energy Technology Data Exchange (ETDEWEB)

    Burklin, C.; Gundappa, M.; Jones, D.

    1996-08-01

    The report gives results of a study that identifies new and innovative air pollution prevention and/or control technologies, of selected industrialized countries, that are not currently used extensively in the U.S. The study addressed technologies that prevent or control the emissions of the pollutants from each of four sources of air pollution: (1) Urban emissions--ozone precursors to include nitrogen oxides (NOx), volatile organic componds (VOCs), particulate matter (PM), and air toxics; (2) Motor vehicle emissions--NOx, carbon monoxide (CO), and PM; (3) Toxic air emissions--any one of the 189 compounds on the list of hazardous air pollutants (HAPs) in the 1990 CAAA (Title III); and (4) Acid deposition--NOx, sulfur oxides (SOx), and, to a lesser extent, VOCs. The report describes the approach taken to identify potentially useful technologies, gives results of the technology search and evaluation, and describes the selected technologies.

  5. Health Technology Assessment: a field still maturing!

    Directory of Open Access Journals (Sweden)

    Renaldo N. Battista

    2005-06-01

    Full Text Available

    With this issue’s focus on Health Technology Assessment (HTA, the Italian Journal of Public Health has tackled an area of growing importance in today’s increasingly complex health care delivery systems.

    As the articles in this issue demonstrate, HTA has grown from a relatively narrow technical focus to a form of policy research underway in dozens of countries. Since its inception just over three decades ago,HTA has evolved through three distinct phases: the machine, the disease and the delivery mode, with the third of these still underway.

    As the focus has shifted from machines to disease conditions to service delivery approaches, HTA has drawn on research and modes of discourse from a growing variety of disciplines. Thus, despite the evolution that continues, HTA remains, at its core, both multidisciplinary and pragmatic, for the strengths of HTA arise from its integration of the efforts of actors in multiple, diverse disciplines with a view to producing knowledge that will assist decision-makers. The machine phase was marked by a focus on the technical performance of health technologies, often embodying innovative approaches to diagnosis or treatment of human illness.

    Given the newness and costliness of many technologies selected for assessment, a significant emphasis was placed on assessing the safety of these devices. Imaging technologies were the subject of assessment in many settings, perhaps in part because devices such as the CT scanner produced remarkable visual results that were heralded as affording breakthroughs in diagnosis and treatment. One need only look through the programs of early HTA conferences to see the emphasis on high cost, infrastructure-intensive health technologies that was the hallmark of the machine period.

  6. Static Heat Loads in the LHC Arc Cryostats: Final Assessment

    CERN Document Server

    Parma, V

    2010-01-01

    This note presents the final assessment of the static heat loads in the LHC arc cryostats, using different experimental methods during the first commissioning period in 2007. This assessment further develops and completes previous estimates made during the commissioning of sector 7_8 [1]. The estimate of the helium inventory, a prerequisite for the heat load calculation, is also presented. Heat loads to the cold mass are evaluated from the internal energy balance during natural as well as powered warm-ups of the helium baths in different subsector. The helium inventory is calculated from the internal energy balance during powered warm-ups and matched with previous assessments. Furthermore, heat loads to the thermal shield are estimated from the non-isothermal cooling of the supercritical helium in line E. The comparison of measured heat loads with previous estimates and with budgeted values is then presented, while their correlation with some important parameters like insulation vacuum pressure and some heat ...

  7. Technology Audit: Assessment of Innovative Portfolio

    Directory of Open Access Journals (Sweden)

    Kurushina Viktoria

    2016-01-01

    Full Text Available The article discusses the features of the technological audit performing in the companies of oil and gas sector of Russian economy. To measure the innovations quality level the scale was developed based on the Theory of Inventive Problem Solving and the theory of technological structures. Figures of the innovations quantity by levels, volume and quality of the innovative portfolio are offered for assessment the innovative portfolio quality. The method was tested on an example of oil and gas transporting enterprises. The results of the comparative analysis of innovative portfolio are shown.

  8. Final voluntary release assessment/corrective action report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-12

    The US Department of Energy, Carlsbad Area Office (DOE-CAO) has completed a voluntary release assessment sampling program at selected Solid Waste Management Units (SWMUs) at the Waste Isolation Pilot Plant (WIPP). This Voluntary Release Assessment/Corrective Action (RA/CA) report has been prepared for final submittal to the Environmental protection Agency (EPA) Region 6, Hazardous Waste Management Division and the New Mexico Environment Department (NMED) Hazardous and Radioactive Materials Bureau to describe the results of voluntary release assessment sampling and proposed corrective actions at the SWMU sites. The Voluntary RA/CA Program is intended to be the first phase in implementing the Resource Conservation and Recovery Act (RCRA) Facility Investigation (RFI) and corrective action process at the WIPP. Data generated as part of this sampling program are intended to update the RCRA Facility Assessment (RFA) for the WIPP (Assessment of Solid Waste Management Units at the Waste Isolation Pilot Plant), NMED/DOE/AIP 94/1. This Final Voluntary RA/CA Report documents the results of release assessment sampling at 11 SWMUs identified in the RFA. With this submittal, DOE formally requests a No Further Action determination for these SWMUs. Additionally, this report provides information to support DOE`s request for No Further Action at the Brinderson and Construction landfill SWMUs, and to support DOE`s request for approval of proposed corrective actions at three other SWMUs (the Badger Unit Drill Pad, the Cotton Baby Drill Pad, and the DOE-1 Drill Pad). This information is provided to document the results of the Voluntary RA/CA activities submitted to the EPA and NMED in August 1995.

  9. Networking and Information Technology Workforce Study: Final Report

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — This report presents the results of a study of the global Networking and Information Technology NIT workforce undertaken for the Networking and Information...

  10. Progress in diagnosis of breast cancer: Advances in radiology technology

    Directory of Open Access Journals (Sweden)

    J Mari Beth Linder

    2015-01-01

    Full Text Available Breast cancer is the leading cause of cancer in females between the ages of 15 and 54, and the second leading cause of cancer death in women in the United States. Diagnosis begins with detection by breast examination (clinical breast exam or breast self-exam or by radiologic studies, like mammography. Many advances in the diagnosis of breast cancer have taken place in recent years. This article will review the history of radiologic advances in the diagnosis of breast cancer. Use of technological advancements in digital breast tomosynthesis, magnetic resonance imaging, and ultrasound in breast cancer diagnosis will be presented. Advantages and disadvantages of these diagnostic interventions when compared to older, traditional X-ray films will be discussed. It is important for all nurses, including radiology and oncology nurses, to be well informed about these varied diagnostic modalities, and appreciate the fact that advances in radiologic imaging technologies can yield improved outcomes for breast cancer patients.

  11. Quantification for complex assessment: uncertainty estimation in final year project thesis assessment

    Science.gov (United States)

    Kim, Ho Sung

    2013-12-01

    A quantitative method for estimating an expected uncertainty (reliability and validity) in assessment results arising from the relativity between four variables, viz examiner's expertise, examinee's expertise achieved, assessment task difficulty and examinee's performance, was developed for the complex assessment applicable to final year project thesis assessment including peer assessment. A guide map can be generated by the method for finding expected uncertainties prior to the assessment implementation with a given set of variables. It employs a scale for visualisation of expertise levels, derivation of which is based on quantified clarities of mental images for levels of the examiner's expertise and the examinee's expertise achieved. To identify the relevant expertise areas that depend on the complexity in assessment format, a graphical continuum model was developed. The continuum model consists of assessment task, assessment standards and criterion for the transition towards the complex assessment owing to the relativity between implicitness and explicitness and is capable of identifying areas of expertise required for scale development.

  12. Energy Effectiveness Assessment of Composting Technologies

    OpenAIRE

    Plūme, I.

    2006-01-01

    The incorrect biomass composting improperly results in considerable emission of greenhouse gases, loss of effluent and composting heat into environment. The composting heat and gases utilisation is especially suitable for plant enrichment and heating of greenhouses. The mathematical model is worked out for assessment of energy effectiveness and sustainability of biomass composting process. Coefficient of energy effectiveness for traditional litter manure composting technologies is 0.45 and ca...

  13. Natural-technological risk assessment and management

    Science.gov (United States)

    Burova, Valentina; Frolova, Nina

    2016-04-01

    EM-DAT statistical data on human impact and economic damages in the 1st semester 2015 are the highest since 2011: 41% of disasters were floods, responsible for 39% of economic damage and 7% of events were earthquakes responsible for 59% of total death toll. This suggests that disaster risk assessment and management still need to be improved and stay the principle issue in national and international related programs. The paper investigates the risk assessment and management practice in the Russian Federation at different levels. The method is proposed to identify the territories characterized by integrated natural-technological hazard. The maps of the Russian Federation zoning according to the integrated natural-technological hazard level are presented, as well as the procedure of updating the integrated hazard level taking into account the activity of separate processes. Special attention is paid to data bases on past natural and technological processes consequences, which are used for verification of current hazard estimation. The examples of natural-technological risk zoning for the country and some regions territory are presented. Different output risk indexes: both social and economic, are estimated taking into account requirements of end-users. In order to increase the safety of population of the Russian Federation the trans-boundaries hazards are also taken into account.

  14. RECOVERY ACT - Methods for Decision under Technological Change Uncertainty and Risk Assessment for Integrated Assessment of Climate Change

    Energy Technology Data Exchange (ETDEWEB)

    Webster, Mort David [MIT

    2015-03-10

    This report presents the final outcomes and products of the project as performed at the Massachusetts Institute of Technology. The research project consists of three main components: methodology development for decision-making under uncertainty, improving the resolution of the electricity sector to improve integrated assessment, and application of these methods to integrated assessment. Results in each area is described in the report.

  15. RECOVERY ACT - Methods for Decision under Technological Change Uncertainty and Risk Assessment for Integrated Assessment of Climate Change

    Energy Technology Data Exchange (ETDEWEB)

    Webster, Mort D. [Pennsylvania State Univ., University Park, PA (United States). Dept. of Energy and Mineral Engineering

    2015-11-30

    This report presents the final outcomes and products of the project as performed both at the Massachusetts Institute of Technology and subsequently at Pennsylvania State University. The research project can be divided into three main components: methodology development for decision-making under uncertainty, improving the resolution of the electricity sector to improve integrated assessment, and application of these methods to integrated assessment.

  16. Finding Qualitative Research Evidence for Health Technology Assessment.

    Science.gov (United States)

    DeJean, Deirdre; Giacomini, Mita; Simeonov, Dorina; Smith, Andrea

    2016-08-01

    Health technology assessment (HTA) agencies increasingly use reviews of qualitative research as evidence for evaluating social, experiential, and ethical aspects of health technologies. We systematically searched three bibliographic databases (MEDLINE, CINAHL, and Social Science Citation Index [SSCI]) using published search filters or "hedges" and our hybrid filter to identify qualitative research studies pertaining to chronic obstructive pulmonary disease and early breast cancer. The search filters were compared in terms of sensitivity, specificity, and precision. Our screening by title and abstract revealed that qualitative research constituted only slightly more than 1% of all published research on each health topic. The performance of the published search filters varied greatly across topics and databases. Compared with existing search filters, our hybrid filter demonstrated a consistently high sensitivity across databases and topics, and minimized the resource-intensive process of sifting through false positives. We identify opportunities for qualitative health researchers to improve the uptake of qualitative research into evidence-informed policy making.

  17. Environmental assessment of advanced thin film manufacturing process. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Cunningham, D.W.; Mopas, E.; Skinner, D. [BP Solar, Inc., Fairfield, CA (United States); McGuire, L.; Strehlow, M. [Radian International, Walnut Creek, CA (United States)

    1998-09-01

    This report describes work performed by BP Solar, Inc., to provide an extensive preproduction analysis of waste-stream abatement at its plant in Fairfield, California. During the study, numerous technologies were thoroughly evaluated, which allowed BP Solar to select systems that outperformed the stringent federal and state regulations. The main issues were originally perceived to be controlling cadmium compound releases to both air and wastewater to acceptable levels and adopting technologies for air and water waste streams in an efficient, cost-effective manner. BP Solar proposed high-efficiency, reliable control equipment that would reduce air-contaminant emission levels below levels of concern. Cadmium telluride dust is successfully controlled with high-efficiency (>99.9%) bag-in/bag-out filters. For air abatement, carbon canisters provide efficient VOC reduction, and wastewater pretreatment is required per federal pretreatment standards. BP Solar installed a cadmium-scavenging ion exchange system and electrowinning system capable of removing cadmium to <10 ppb (local publicly-owned-treatment-works limits for cadmium is 30 ppb). BP Solar plans to maximize potential reuse of rinse waters by phasing in additional wastewater treatment technologies. Finally, the work to date has identified the areas that need to be revisited as production scales up to ensure that all health, safety, and environmental goals are met.

  18. Uncertainties related to the identification of the marginal energy technology in consequential life cycle assessments

    DEFF Research Database (Denmark)

    Mathiesen, B.V.; Münster, Marie; Fruergaard, Thilde

    2009-01-01

    When performing life cycle assessment (LCA) assumptions regarding the energy use are often decisive for the outcome. In this paper, current approaches of identifying marginal electricity and heat technologies for consequential LCAs are challenged. The identification of marginal energy technologies...... is examined from three angles: The marginal electricity technology is identified in Danish historical and potential future energy systems. The methods of identifying and using marginal electricity and heat technologies in key LCA studies are analysed. Finally, the differences in applying energy system...

  19. Pecan Street Grid Demonstration Program. Final technology performance report

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2015-02-10

    This document represents the final Regional Demonstration Project Technical Performance Report (TPR) for Pecan Street Inc.’s (Pecan Street) Smart Grid Demonstration Program, DE-OE-0000219. Pecan Street is a 501(c)(3) smart grid/clean energy research and development organization headquartered at The University of Texas at Austin (UT). Pecan Street worked in collaboration with Austin Energy, UT, Environmental Defense Fund (EDF), the City of Austin, the Austin Chamber of Commerce and selected consultants, contractors, and vendors to take a more detailed look at the energy load of residential and small commercial properties while the power industry is undergoing modernization. The Pecan Street Smart Grid Demonstration Program signed-up over 1,000 participants who are sharing their home or businesses’s electricity consumption data with the project via green button protocols, smart meters, and/or a home energy monitoring system (HEMS). Pecan Street completed the installation of HEMS in 750 homes and 25 commercial properties. The program provided incentives to increase the installed base of roof-top solar photovoltaic (PV) systems, plug-in electric vehicles with Level 2 charging, and smart appliances. Over 200 participants within a one square mile area took advantage of Austin Energy and Pecan Street’s joint PV incentive program and installed roof-top PV as part of this project. Of these homes, 69 purchased or leased an electric vehicle through Pecan Street’s PV rebate program and received a Level 2 charger from Pecan Street. Pecan Street studied the impacts of these technologies along with a variety of consumer behavior interventions, including pricing models, real-time feedback on energy use, incentive programs, and messaging, as well as the corresponding impacts on Austin Energy’s distribution assets.The primary demonstration site was the Mueller community in Austin, Texas. The Mueller development, located less than three miles from the Texas State Capitol

  20. Emerging Communication Technologies (ECT) Phase 3 Final Report

    Science.gov (United States)

    Bastin, Gary L.; Harris, William G.; Bates, Lakesha D.; Nelson, Richard A.

    2004-01-01

    The Emerging Communication Technology (ECT) project investigated three First Mile communication technologies in support of NASA s Second Generation Reusable Launch Vehicle (2nd Gen RLV), Orbital Space Plane, Advanced Range Technology Working Group (ARTWG) and the Advanced Spaceport Technology Working Group (ASTWG). These First Mile technologies have the purpose of interconnecting mobile users with existing Range Communication infrastructures. ECT was a continuation of the Range Information System Management (RISM) task started in 2002. RISM identified the three advance communication technologies investigated under ECT. These were Wireless Ethernet (Wi-Fi), Free Space Optics (FSO), and Ultra Wideband (UWB). Due to the report s size, it has been broken into three volumes: 1) Main Report 2) Appendices 3) UWB.

  1. Cancer proteomics: developments in technology, clinical use and commercialization.

    Science.gov (United States)

    Yeat, Nai Chien; Lin, Charlotte; Sager, Monica; Lin, Jimmy

    2015-08-01

    In the last two decades, advances in genomic, transcriptomic and proteomic methods have enabled us to identify and classify cancers by their molecular profiles. Many anticipate that a molecular taxonomy of cancer will not only lead to more effective subtyping of cancers but also earlier diagnoses, more informative prognoses and more targeted treatments. This article reviews recent technological developments in the field of proteomics, recent discoveries in proteomic cancer biomarker research and trends in clinical use. Readers are also informed of examples of successful commercialization, and the future of proteomics in cancer diagnostics.

  2. The development of health technology assessment.

    Science.gov (United States)

    Banta, David

    2003-02-01

    The field of health technology assessment (HTA) is still relatively new, but it has shown remarkable growth over the last decade, having spread first from the United States to Europe, and now to the entire world. HTA seeks to couple evidence with decision-making, and thus has similarities to evidence-based health care and evidence-based policy-making. The early history of HTA, beginning around 1975, reveals a first period of synthesising available evidence-principally that dealing with efficacy and cost-effectiveness of health care interventions-so as to put it in a format helpful to health policy-makers, especially those in national governments. From 1985 or so, the focus of the second period was on seeking more effective links with these policy-makers, particularly in Europe. The most recent period, beginning in the late 1990s, has been increasingly devoted to more effective dissemination and implementation in order to influence administrators and clinicians. While early assessments tended to focus on large, expensive, machine-based technologies, the scope has gradually widened to include smaller technologies, 'softer' technologies (such as counselling), and health care needs. Actual assessments have also taken on broader issues, such as organisational, social, and ethical implications. In the Member States of the European Union (EU), HTA activities are increasingly visible, and almost all now have a national focus for HTA associated with the Ministry of Health or its equivalent. Central and Eastern European countries are also developing HTA activities. Most recently, HTA has been highlighted by health policy documents from the European Commission. It seems likely that HTA will in the future be institutionalised in some form as part of EU activities.

  3. Development of vehicle magnetic air conditioner (VMAC) technology. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Gschneidner, Karl A., Jr.; Pecharsky, V.K.; Jiles, David; Zimm, Carl B.

    2001-08-28

    The objective of Phase I was to explore the feasibility of the development of a new solid state refrigeration technology - magnetic refrigeration - in order to reduce power consumption of a vehicle air conditioner by 30%. The feasibility study was performed at Iowa State University (ISU) together with Astronautics Corporation of America Technology Center (ACATC), Madison, WI, through a subcontract with ISU.

  4. Tiger Team Assessment, Energy Technology Engineering Center

    Energy Technology Data Exchange (ETDEWEB)

    1991-04-01

    The Office Special Projects within the Office of Environment, Safety, and Health (EH) has the responsibility to conduct Tiger Team Assessments for the Secretary of Energy. This report presents the assessment of the buildings, facilities, and activities under the DOE/Rockwell Contract No. DE-AM03-76SF00700 for the Energy Technology Engineering Center (ETEC) and of other DOE-owned buildings and facilities at the Santa Susana Field Laboratory (SSFL) site in southeastern Ventura County, California, not covered under Contract No. DE-AM03-76SF00700, but constructed over the years under various other contracts between DOE and Rockwell International. ETEC is an engineering development complex operated for DOE by the Rocketdyne Division of Rockwell International Corporation. ETEC is located within SSFL on land owned by Rockwell. The balance of the SSFL complex is owned and operated by Rocketdyne, with the exception of a 42-acre parcel owned by the National Aeronautics and Space Administration (NASA). The primary mission of ETEC is to provide engineering, testing, and development of components related to liquid metals technology and to conduct applied engineering development of emerging energy technologies.

  5. Assessing the performance of health technology assessment organizations: a framework.

    Science.gov (United States)

    Lafortune, Louise; Farand, Lambert; Mondou, Isabelle; Sicotte, Claude; Battista, Renaldo

    2008-01-01

    In light of growing demands for public accountability, the broadening scope of health technology assessment organizations (HTAOs) activities and their increasing role in decision-making underscore the importance for them to demonstrate their performance. Based on Parson's social action theory, we propose a conceptual model that includes four functions an organization needs to balance to perform well: (i) goal attainment, (ii) production, (iii) adaptation to the environment, and (iv) culture and values maintenance. From a review of the HTA literature, we identify specific dimensions pertaining to the four functions and show how they relate to performance. We compare our model with evaluations reported in the scientific and gray literature to confirm its capacity to accommodate various evaluation designs, contexts of evaluation, and organizational models and perspectives. Our findings reveal the dimensions of performance most often assessed and other important ones that, hitherto, remain unexplored. The model provides a flexible and theoretically grounded tool to assess the performance of HTAOs.

  6. Prolactin and cancer: Has the orphan finally found a home?

    Directory of Open Access Journals (Sweden)

    Bipin Kumar Sethi

    2012-01-01

    Full Text Available Prolactin has, for long, been associated with galactorrhea and infertility in women while its role in men is largely unknown. Recently, expression of prolactin in various other tissues like the breast, prostate, decidua, and the brain has been recognized. This has led to evaluation of paracrine and autocrine actions of prolactin at these tissues and a possible role in development of various cancers. Increased expression of PRL receptors has also been implicated in carcinogenesis. Breast cancer has the strongest association with increased prolactin and prolactin receptor levels. Prostate cancer also has reported significant association, while the role of prolactin in colorectal, gynecological, laryngeal, and hepatocellular cancers is more tenuous. Prolactin/prolactin receptor pathway has also been implicated in development of resistance to chemotherapy. Thus, the effects of this pathway in carcinogenesis seem widespread. At the same time, they also offer an exciting new approach to hormonal manipulation of cancers, especially the treatment-resistant cancers.

  7. Final report. CIRP seminar on micro and nano technology. November 2003

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard; Alting, Leo

    This final reports contains a description of the 1st international CIRP seminar on micro and nano technology held at DTU in November 2003.......This final reports contains a description of the 1st international CIRP seminar on micro and nano technology held at DTU in November 2003....

  8. BMDO: New Mexico Technology Transfer Demonstration Project. Interim final report

    Energy Technology Data Exchange (ETDEWEB)

    1993-11-01

    The BMDO-New Mexico Technology Transfer Demonstration Project(BMDO-NM) was a collaborative effort among the national laboratories to identify and evaluate the commercial potential of selected SDI-funded technologies. The project was funded by BMDO (formerly known as the Strategic Defense Initiative Office or SDIO), the Technology Enterprise Division (NM-TED) of the NM Economic Development Division, and the three National Laboratories. The project was managed and supervised by SAGE Management Partners of Albuquerque, and project funding was administered through the University of New Mexico. The BMDO-NM Demonstration Project focused on the development of a process to assist technology developers in the evaluation of selected BMDO technology programs so that commercialization decisions can be made in an accelerated manner. The project brought together BMDO, the NM-TED, the University of New Mexico, and three New Mexico Federal laboratories -- Los Alamos (DOE), Phillips (DOD) and Sandia (DOE). Each national laboratory actively participated throughout the project through its technology transfer offices. New Mexico was selected as the site for the Demonstration Program because of its three national and federal research laboratories engaged in BMDO programs, and the existing relationship among state govemment, the labs, universities and local economic development and business assistance organizations. Subsequent Commercialization and Implementation phases for the selected technologies from LANL and SNL were completed by SAGE and the Project Team. Funding for those phases was provided by the individual labs as well as BMDO and NM-TED in kind services. NM-TED played a proactive role in this New Mexico partnership. Its mandate is to promote technology-based economic development, with a commitment to facilitate the use of technology by industry and business statewide. TED assumed the role of program manager and executing agent for BMDO in this demonstration project.

  9. ['Medical technology assessment'; more than just efficacy].

    Science.gov (United States)

    Buskens, E

    2000-03-25

    'Medical technology assessment' means investigating the developments, costs and effects of medical technologies. Practising physicians increasingly are confronted with consequences of management based on such research results. In order to follow and participate in the discussion they should be aware of this and know the jargon. In policy problems, measures of effect in natural units (e.g. cardiovascular mortality) offer advantages over measures of clinical findings (e.g. decrease of the serum cholesterol levels). Survival in various health states and disorders can be compared by multiplying the number of life years gained by a factor for the quality of life in those years. Costs are usually expressed in monetary terms. These may be calculated as direct medical costs on the basis of fees or actual costs for society. The latter is the case when the balancing is based on a societal perspective. The societal perspective enables a more objective assessment of health effects than when a patient perspective is used. 'Incremental cost effectiveness' expresses where extra expenditures will have maximum effect, and bears higher relevance for policy decisions than mean costs per unit of effect. Immaterial matters are more difficult to assess, but should nevertheless be considered in selecting the policy to be implemented.

  10. Information communication technology: new approach for rural cancer care improvement.

    Science.gov (United States)

    Maserat, Elham

    2008-01-01

    Cancer control aims to reduce the incidence, morbidity, and mortality of cancer and to improve the quality of life of cancer patients. For rural populations this presents particular problems. This article covers challenges of oncology care in rural areas and solutions via applying information communication technology with specialty telemedicine for overcoming problems in prevention, early diagnosis, treatment, and palliative care. In addition, telecommunications infrastructures and frameworks for implementation of telemedicine are described.

  11. District heating and cooling technology selection and characterization. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Metz, P.D.; Catan, M.; Piraino, M.; Timmerman, R.W.; Gleason, J.

    1986-03-01

    This report describes the district heating and cooling (DHC) technology selection and characterization tasks performed under Part I of the project ''District Heating and Cooling Market Potential and Penetration Study'' for the USDOE. The purpose of this project is to determine the applicability of various DHC technologies to different community types and regions of the country. The results will be used by DOE to guide R and D program planning.

  12. Quantitative assessment model for gastric cancer screening

    Institute of Scientific and Technical Information of China (English)

    Kun Chen; Wei-Ping Yu; Liang Song; Yi-Min Zhu

    2005-01-01

    AIM: To set up a mathematic model for gastric cancer screening and to evaluate its function in mass screening for gastric cancer.METHODS: A case control study was carried on in 66patients and 198 normal people, then the risk and protective factors of gastric cancer were determined, including heavy manual work, foods such as small yellow-fin tuna, dried small shrimps, squills, crabs, mothers suffering from gastric diseases, spouse alive, use of refrigerators and hot food,etc. According to some principles and methods of probability and fuzzy mathematics, a quantitative assessment model was established as follows: first, we selected some factors significant in statistics, and calculated weight coefficient for each one by two different methods; second, population space was divided into gastric cancer fuzzy subset and non gastric cancer fuzzy subset, then a mathematic model for each subset was established, we got a mathematic expression of attribute degree (AD).RESULTS: Based on the data of 63 patients and 693 normal people, AD of each subject was calculated. Considering the sensitivity and specificity, the thresholds of AD values calculated were configured with 0.20 and 0.17, respectively.According to these thresholds, the sensitivity and specificity of the quantitative model were about 69% and 63%.Moreover, statistical test showed that the identification outcomes of these two different calculation methods were identical (P>0.05).CONCLUSION: The validity of this method is satisfactory.It is convenient, feasible, economic and can be used to determine individual and population risks of gastric cancer.

  13. Taiwan industrial cooperation program technology transfer for low-level radioactive waste final disposal - phase I.

    Energy Technology Data Exchange (ETDEWEB)

    Knowlton, Robert G.; Cochran, John Russell; Arnold, Bill Walter; Jow, Hong-Nian; Mattie, Patrick D.; Schelling, Frank Joseph Jr. (; .)

    2007-01-01

    Sandia National Laboratories and the Institute of Nuclear Energy Research, Taiwan have collaborated in a technology transfer program related to low-level radioactive waste (LLW) disposal in Taiwan. Phase I of this program included regulatory analysis of LLW final disposal, development of LLW disposal performance assessment capabilities, and preliminary performance assessments of two potential disposal sites. Performance objectives were based on regulations in Taiwan and comparisons to those in the United States. Probabilistic performance assessment models were constructed based on limited site data using software including GoldSim, BLT-MS, FEHM, and HELP. These software codes provided the probabilistic framework, container degradation, waste-form leaching, groundwater flow, radionuclide transport, and cover infiltration simulation capabilities in the performance assessment. Preliminary performance assessment analyses were conducted for a near-surface disposal system and a mined cavern disposal system at two representative sites in Taiwan. Results of example calculations indicate peak simulated concentrations to a receptor within a few hundred years of LLW disposal, primarily from highly soluble, non-sorbing radionuclides.

  14. TECHNOLOGY ASSESSMENT OF TIRE MOULD CLEANING SYSTEMS AND QUALITY FINISHING

    Directory of Open Access Journals (Sweden)

    Cristiano Fragassa

    2016-09-01

    Full Text Available A modern tire merges up to 300 different chemical elements, both organic and inorganic, natural and synthetic. During manufacturing, various processes are present such as mixing, calendering and extrusion, forming dozens of individual parts. Then, moulding and vulcanization inside special moulds provides the tire its final shape. Since the surface quality of moulds strongly affects the quality of tire, mould cleaning is a fundamental aspect of the whole tire production and cleaning techniques are in continuous development. This investigation proposes a global technology assessment of tire mould cleaning systems including uncommon solutions as multi-axis robots for cleaning on board by laser or dry ice, or ultrasonic cleaning which use cavitation. A specific attention is also focused on the industry adoption of spring-vents in moulds and how they are influencing the development the quality of final products.

  15. Mobile technology for mental health assessment.

    Science.gov (United States)

    Areàn, Patricia A; Hoa Ly, Kien; Andersson, Gerhard

    2016-06-01

    Assessment and outcome monitoring are critical for the effective detection and treatment of mental illness. Traditional methods of capturing social, functional, and behavioral data are limited to the information that patients report back to their health care provider at selected points in time. As a result, these data are not accurate accounts of day-to-day functioning, as they are often influenced by biases in self-report. Mobile technology (mobile applications on smartphones, activity bracelets) has the potential to overcome such problems with traditional assessment and provide information about patient symptoms, behavior, and functioning in real time. Although the use of sensors and apps are widespread, several questions remain in the field regarding the reliability of off-the-shelf apps and sensors, use of these tools by consumers, and provider use of these data in clinical decision-making.

  16. Final priority; Rehabilitation Services Administration--Assistive Technology Alternative Financing Program. Final priority.

    Science.gov (United States)

    2014-08-14

    The Assistant Secretary for Special Education and Rehabilitative Services announces a priority under the Assistive Technology Alternative Financing Program administered by the Rehabilitation Services Administration (RSA). The Assistant Secretary may use this priority for competitions in fiscal year (FY) 2014 and later years. This priority is designed to ensure that the Department funds high-quality assistive technology (AT) alternative financing programs (AFPs) that meet rigorous standards in order to enable individuals with disabilities to access and acquire assistive technology devices and services necessary to achieve education, community living, and employment goals.

  17. Project on Application of Modern Communication Technologies to Educational Networking. Final Technical Report.

    Science.gov (United States)

    Morgan, Robert P.; Eastwood, Lester F., Jr.

    Research on this National Science Foundation grant to study the application of modern communications technology to educational networking was divided into three parts: assessment of the role of technology in non-traditional post-secondary education; assessment of communications technologies and educational services of current or potential future…

  18. Inhalation cancer risk assessment of cobalt metal.

    Science.gov (United States)

    Suh, Mina; Thompson, Chad M; Brorby, Gregory P; Mittal, Liz; Proctor, Deborah M

    2016-08-01

    Cobalt compounds (metal, salts, hard metals, oxides, and alloys) are used widely in various industrial, medical and military applications. Chronic inhalation exposure to cobalt metal and cobalt sulfate has caused lung cancer in rats and mice, as well as systemic tumors in rats. Cobalt compounds are listed as probable or possible human carcinogens by some agencies, and there is a need for quantitative cancer toxicity criteria. The U.S. Environmental Protection Agency has derived a provisional inhalation unit risk (IUR) of 0.009 per μg/m(3) based on a chronic inhalation study of soluble cobalt sulfate heptahydrate; however, a recent 2-year cancer bioassay affords the opportunity to derive IURs specifically for cobalt metal. The mechanistic data support that the carcinogenic mode of action (MOA) is likely to involve oxidative stress, and thus, non-linear/threshold mechanisms. However, the lack of a detailed MOA and use of high, toxic exposure concentrations in the bioassay (≥1.25 mg/m(3)) preclude derivation of a reference concentration (RfC) protective of cancer. Several analyses resulted in an IUR of 0.003 per μg/m(3) for cobalt metal, which is ∼3-fold less potent than the provisional IUR. Future research should focus on establishing the exposure-response for key precursor events to improve cobalt metal risk assessment.

  19. [Advanced information technologies for financial services industry]. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-01-01

    The project scope is to develop an advanced user interface utilizing speech and/or handwriting recognition technology that will improve the accuracy and speed of recording transactions in the dynamic environment of a foreign exchange (FX) trading floor. The project`s desired result is to improve the base technology for trader`s workstations on FX trading floors. Improved workstation effectiveness will allow vast amounts of complex information and events to be presented and analyzed, thus increasing the volume of money and other assets to be exchanged at an accelerated rate. The project scope is to develop and demonstrate technologies that advance interbank check imaging and paper check truncation. The following describes the tasks to be completed: (1) Identify the economics value case, the legal and regulatory issues, the business practices that are affected, and the effects upon settlement. (2) Familiarization with existing imaging technology. Develop requirements for image quality, security, and interoperability. Adapt existing technologies to meet requirements. (3) Define requirements for the imaging laboratory and design its architecture. Integrate and test technology from task 2 with equipment in the laboratory. (4) Develop and/or integrate and test remaining components; includes security, storage, and communications. (5) Build a prototype system and test in a laboratory. Install and run in two or more banks. Develop documentation. Conduct training. The project`s desired result is to enable a proof-of-concept trial in which multiple banks will exchange check images, exhibiting operating conditions which a check experiences as it travels through the payments/clearing system. The trial should demonstrate the adequacy of digital check images instead of paper checks.

  20. INL Control System Situational Awareness Technology Final Report 2013

    Energy Technology Data Exchange (ETDEWEB)

    Gordon Rueff; Bryce Wheeler; Todd Vollmer; Tim McJunkin

    2013-01-01

    The Situational Awareness project is a comprehensive undertaking of Idaho National Laboratory (INL) in an effort to produce technologies capable of defending the country’s energy sector infrastructure from cyber attack. INL has addressed this challenge through research and development of an interoperable suite of tools that safeguard critical energy sector infrastructure. The technologies in this project include the Sophia Tool, Mesh Mapper (MM) Tool, Intelligent Cyber Sensor (ICS) Tool, and Data Fusion Tool (DFT). Each is designed to function effectively on its own, or they can be integrated in a variety of customized configurations based on the end user’s risk profile and security needs.

  1. Cast Metals Coalition Technology Transfer and Program Management Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Gwyn, Mike

    2009-03-31

    The Cast Metals Coalition (CMC) partnership program was funded to ensure that the results of the Department of Energy's (DOE) metalcasting research and development (R&D) projects are successfully deployed into industry. Specifically, the CMC program coordinated the transfer and deployment of energy saving technologies and process improvements developed under separately funded DOE programs and projects into industry. The transition of these technologies and process improvements is a critical step in the path to realizing actual energy savings. At full deployment, DOE funded metalcasting R&D results are projected to save 55% of the energy used by the industry in 1998. This closely aligns with DOE's current goal of driving a 25% reduction in industrial energy intensity by 2017. In addition to benefiting DOE, these energy savings provide metalcasters with a significant economic advantage. Deployment of already completed R&D project results and those still underway is estimated to return over 500% of the original DOE and industry investment. Energy savings estimates through December 2008 from the Energy-Saving Melting and Revert Reduction Technology (E-SMARRT) portfolio of projects alone are 12 x 1012 BTUs, with a projection of over 50 x 1012 BTUs ten years after program completion. These energy savings and process improvements have been made possible through the unique collaborative structure of the CMC partnership. The CMC team consists of DOE's Office of Industrial Technology, the three leading metalcasting technical societies in the U.S: the American Foundry Society; the North American Die Casting Association; and the Steel Founders Society of America; and the Advanced Technology Institute (ATI), a recognized leader in distributed technology management. CMC provides collaborative leadership to a complex industry composed of approximately 2,100 companies, 80% of which employ less than 100 people, and only 4% of which employ more than 250 people

  2. XMRV and prostate cancer--a 'final' perspective.

    Science.gov (United States)

    Sfanos, Karen S; Aloia, Amanda L; De Marzo, Angelo M; Rein, Alan

    2012-01-10

    XMRV was first described in 2006, when it was identified in samples isolated from prostate cancer tissues. However, studies have since shown that XMRV arose in the laboratory and was formed by genetic recombination between two viral genomes carried in the germline DNA of mice used during serial transplantation of the CWR22 prostate cancer xenograft. These new findings strongly imply that XMRV does not circulate in humans, but is only present in the laboratory. Thus, there is no reason to believe that it has any role in the etiology of prostate cancer or other diseases.

  3. Final Report on HOLODEC 2 Technology Readiness Level

    Energy Technology Data Exchange (ETDEWEB)

    Shaw, RA; Spuler, SM; Beals, M; Black, N; Fugal, JP; Lu, L

    2012-06-18

    During the period of this project, the Holographic Detector for Clouds 2 (HOLODEC 2) instrument has advanced from a laboratory-proven instrument with some initial field testing to a fully flight-tested instrument capable of providing useful cloud microphysics measurements. This can be summarized as 'Technology Readiness Level 8: Technology is proven to work - Actual technology completed and qualified through test and demonstration.' As part of this project, improvements and upgrades have been made to the optical system, the instrument power control system, the data acquisition computer, the instrument control software, the data reconstruction and analysis software, and some of the basic algorithms for estimating basic microphysical variables like droplet diameter. Near the end of the project, the instrument flew on several research flights as part of the IDEAS 2011 project, and a small sample of data from the project is included as an example. There is one caveat in the technology readiness level stated above: the upgrades to the instrument power system were made after the flight testing, so they are not fully field proven. We anticipate that there will be an opportunity to fly the instrument as part of the IDEAS project in fall 2012.

  4. Technology, Division of Labor and Alienation From Work. Final Report.

    Science.gov (United States)

    Shepard, Jon M.

    This study investigated the theory that a worker's relationship to technology instills in him identifiable attitudes about work. Using samples of office workers from a bank and five insurance companies, and samples of factory workers from the oil refining and automobile industries, a total of 1,888 workers were divided into (1) office and factory…

  5. Breast Cancer Risk Assessment SAS Macro (Gail Model)

    Science.gov (United States)

    A SAS macro (commonly referred to as the Gail Model) that projects absolute risk of invasive breast cancer according to NCI’s Breast Cancer Risk Assessment Tool (BCRAT) algorithm for specified race/ethnic groups and age intervals.

  6. Flammability Assessment Methodology Program Phase I: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    C. A. Loehr; S. M. Djordjevic; K. J. Liekhus; M. J. Connolly

    1997-09-01

    The Flammability Assessment Methodology Program (FAMP) was established to investigate the flammability of gas mixtures found in transuranic (TRU) waste containers. The FAMP results provide a basis for increasing the permissible concentrations of flammable volatile organic compounds (VOCs) in TRU waste containers. The FAMP results will be used to modify the ''Safety Analysis Report for the TRUPACT-II Shipping Package'' (TRUPACT-II SARP) upon acceptance of the methodology by the Nuclear Regulatory Commission. Implementation of the methodology would substantially increase the number of drums that can be shipped to the Waste Isolation Pilot Plant (WIPP) without repackaging or treatment. Central to the program was experimental testing and modeling to predict the gas mixture lower explosive limit (MLEL) of gases observed in TRU waste containers. The experimental data supported selection of an MLEL model that was used in constructing screening limits for flammable VOC and flammable gas concentrations. The MLEL values predicted by the model for individual drums will be utilized to assess flammability for drums that do not meet the screening criteria. Finally, the predicted MLEL values will be used to derive acceptable gas generation rates, decay heat limits, and aspiration time requirements for drums that do not pass the screening limits. The results of the program demonstrate that an increased number of waste containers can be shipped to WIPP within the flammability safety envelope established in the TRUPACT-II SARP.

  7. Technical and economic assessment of solar hybrid repowering. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-09-01

    Public Service Company of New Mexico (PNM) has performed a Technical and Economic Assessment of Solar Hybrid Repowering under funding by the Department of Energy (DOE), the Electric Power Research Institute (EPRI), Western Energy Supply and Transmission (WEST) Associates, and a number of southwestern utilities. Solar hybrid repowering involves placement of solar hardware adjacent to and connected to existing gas- and oil-fueled electric generation units to displace some of or all the fossil fuel normally used during daylight hours. The subject study assesses the technical economic viability of the solar hybrid repowering concept within the southwestern United States and the PNM system. This document is a final report on the study and its results. The study was divided into the six primary tasks to allow a systematic investigation of the concept: (1) market survey and cost/benefit analysis, (2) study unit selection, (3) conceptual design and cost estimates, (4) unit economic analysis, (5) program planning, future phases, and (6) program management. Reeves Station No. 2 at Albuquerque, New Mexico, was selected for repowering with a design goal of 50 percent (25 MWe). The solar system design is based on the 10 MW solar central receiver pilot plant preliminary design for Barstow, California. SAN--1608-4-2 contains the technical drawings. (WHK)

  8. Life cycle assessment of biogas upgrading technologies.

    Science.gov (United States)

    Starr, Katherine; Gabarrell, Xavier; Villalba, Gara; Talens, Laura; Lombardi, Lidia

    2012-05-01

    This article evaluates the life cycle assessment (LCA) of three biogas upgrading technologies. An in-depth study and evaluation was conducted on high pressure water scrubbing (HPWS), as well as alkaline with regeneration (AwR) and bottom ash upgrading (BABIU), which additionally offer carbon storage. AwR and BABIU are two novel technologies that utilize waste from municipal solid waste incinerators - namely bottom ash (BA) and air pollution control residues (APC) - and are able to store CO(2) from biogas through accelerated carbonation processes. These are compared to high pressure water scrubbing (HPWS) which is a widely used technology in Europe. The AwR uses an alkaline solution to remove the CO(2) and then the solution - rich in carbonate and bicarbonate ions - is regenerated through carbonation of APC. The BABIU process directly exposes the gas to the BA to remove and immediately store the CO(2), again by carbonation. It was determined that the AwR process had an 84% higher impact in all LCA categories largely due to the energy intensive production of the alkaline reactants. The BABIU process had the lowest impact in most categories even when compared to five other CO(2) capture technologies on the market. AwR and BABIU have a particularly low impact in the global warming potential category as a result of the immediate storage of the CO(2). For AwR, it was determined that using NaOH instead of KOH improves its environmental performance by 34%. For the BABIU process the use of renewable energies would improve its impact since accounts for 55% of the impact.

  9. Bridges between science, society and policy technology assessment : methods and impacts

    CERN Document Server

    Ladikas, Miltos

    2004-01-01

    This book summarises the results of the project TAMI (Technology Assessment in Europe; between Method and Impact). This was a two-year project that brought together the main institutes of technology assessment in Europe, both parliamentary and non-parliamentary. TAMI created a structured dialogue between technology assessment experts and policymakers on current methodologies and their impact on policymaking. The TAMI team explored and assessed the whole spectrum of methodologies from the "classical" to the "interactive/participatory" and "communicative," identified good practices in project implementation and set the stage for impact evaluation based on objective criteria. Finally this report offers a series of policy recommendations based on the findings of the project. Science, Society and Policy, are three areas that technology assessment functions within and works for; this book is an attempt to improve the interaction amongst them for a more socially and economically sustainable Science and Technology p...

  10. BRCA1-2 diagnostic workflow from next-generation sequencing technologies to variant identification and final report.

    Science.gov (United States)

    Pilato, Brunella; Pinto, Rosamaria; De Summa, Simona; Petriella, Daniela; Lacalamita, Rosanna; Danza, Katia; Paradiso, Angelo; Tommasi, Stefania

    2016-10-01

    The BRCA1-BRCA2 genes predispose to hereditary breast and ovarian cancer, and the germline and mutational status of these genes defines a target population that can benefit from PARP inhibitor treatments. To respond to the increasing number of BRCA1-BRCA2 tests, it is necessary to shift to high-throughput technologies that are reliable and less time consuming. Different methodological platforms are dedicated to this purpose with different approaches and algorithms for analysis. Our aim was to set up a cost-effective and low time-consuming BRCA1-BRCA2 mutation detection workflow using the Ion Torrent PGM technology. A retrospective cohort of 40 patients with familial breast/ovarian cancer previously tested by Sanger sequencing and a prospective cohort of 72 patients (validation set) were analyzed. The validation set included 64 patients affected by familial breast/ovarian cancer and eight sporadic ovarian cancer cases, who are potential candidates for PARPi treatments. A complete and standardized workflow easily usable and suitable in a certified laboratory has been proved and validated. This includes all steps from library preparation to the final report. The use of next-generation sequencing will be of benefit for patients enrolled in the genetic counseling process and, moreover, will enhance the process of selecting patients eligible for personalized treatments. © 2016 Wiley Periodicals, Inc.

  11. Designing Technology to Address Parent Uncertainty in Childhood Cancer.

    Science.gov (United States)

    Morrison, Caroline F; Szulczewski, Lauren; Strahlendorf, Laura F; Lane, J Blake; Mullins, Larry L; Pai, Ahna L H

    2016-01-01

    The stress and uncertainty created by a child's cancer diagnosis and treatment can affect parent and child functioning. Health technology provides a potential avenue for intervention delivery. Interviews were conducted with parents of children diagnosed with cancer to discover their needs following diagnosis and design a relevant mobile application. Treatment experience was the overarching theme. Subthemes included the emotional response, use of information, and environmental factors. Technology was used primarily to seek out information and communicate with others. Health technologies are gaining popularity and have the potential to be beneficial for patients and families throughout the treatment experience.

  12. The Health Technology Assessment of companion diagnostics: experience of NICE.

    Science.gov (United States)

    Byron, Sarah K; Crabb, Nick; George, Elisabeth; Marlow, Mirella; Newland, Adrian

    2014-03-15

    Companion diagnostics are used to aid clinical decision making to identify patients who are most likely to respond to treatment. They are becoming increasingly important as more new pharmaceuticals receive licensed indications that require the use of a companion diagnostic to identify the appropriate patient subgroup for treatment. These pharmaceuticals have proven benefit in the treatment of some cancers and other diseases, and also have potential to precisely tailor treatments to the individual in the future. However, the increasing use of companion diagnostics could place a substantial burden on health system resources to provide potentially high volumes of testing. This situation, in part, has led policy makers and Health Technology Assessment (HTA) bodies to review the policies and methods used to make reimbursement decisions for pharmaceuticals requiring companion diagnostics. The assessment of a pharmaceutical alongside the companion diagnostic used in the clinical trials may be relatively straightforward, although there are a number of challenges associated with assessing pharmaceuticals where a range of alternative companion diagnostics are available for use in routine clinical practice. The UK HTA body, the National Institute for Health and Care Excellence (NICE), has developed policy for considering companion diagnostics using its Technology Appraisal and Diagnostics Assessment Programs. Some HTA bodies in other countries have also adapted their policies and methods to accommodate the assessment of companion diagnostics. Here, we provide insight into the HTA of companion diagnostics for reimbursement decisions and how the associated challenges are being addressed, in particular by NICE. See all articles in this CCR Focus section, "The Precision Medicine Conundrum: Approaches to Companion Diagnostic Co-development."

  13. Diffusion of energy-efficient technologies in industry. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Hsu, S.Y.

    1979-01-01

    United States energy policies aim at cutting down dependence on foreign oil in two ways: by energy conservation and by finding new domestic supplies. The study investigates how the first goal can be achieved in the industrial sector (manufacturing) of the economy, which accounts for about 40% (about 7.3 million barrels per day) of the total energy consumption in the US. It is noted that industry is able to conserve as much as 25 to 30% of its energy consumption by adopting simple conservation measures and energy-efficient technologies. These technologies can be implemented without major alterations of the original equipment. The schools of thought on innovative processes are discussed; these will serve as the conceptual and methodological base of the project. (MCW)

  14. N+2 Advanced Low NOx Combustor Technology Final Report

    Science.gov (United States)

    Herbon, John; Aicholtz, John; Hsieh, Shih-Yang; Viars, Philip; Birmaher, Shai; Brown, Dan; Patel, Nayan; Carper, Doug; Cooper, Clay; Fitzgerald, Russell

    2017-01-01

    In accordance with NASAs technology goals for future subsonic vehicles, this contract identified and developed new combustor concepts toward meeting N+2 generation (2020) LTO (landing and take-off) NOx emissions reduction goal of 75 from the standard adopted at Committee on Aviation Environmental Protection 6 (CAEP6). Based on flame tube emissions, operability, and autoignition testing, one concept was down selected for sector testing at NASA. The N+2 combustor sector successfully demonstrated 75 reduction for LTO NOx (vs. CAEP6) and cruise NOx (vs. 2005 B777-200 reference) while maintaining 99.9 cruise efficiency and no increase in CO and HC emissions.The program also developed enabling technologies for the combustion system including ceramic matrix composites (CMC) liner materials, active combustion control concepts, and laser ignition for improved altitude relight.

  15. Dechlorination Technology Manual. Final report. [Utility cooling water discharge systems

    Energy Technology Data Exchange (ETDEWEB)

    Aschoff, A.F.; Chiesa, R.J.; Jacobs, M.H.; Lee, Y.H.; Mehta, S.C.; Meko, A.C.; Musil, R.R.; Sopocy, D.M.; Wilson, J.A.

    1984-11-01

    On November 19, 1982, the United States Environmental Protection Agency (EPA) promulgated regulations severely restricting chlorination practices as they relate to utility cooling water discharge systems. EPRI authorized the preparation of a manual on dechlorination technology to assist utilities in evaluating the various alternatives available to them to meet these new requirements. The Dechlorination Technology Manual emphasizes the engineering aspects involved in the selection and design of dechlorination systems. However, background information is included concerning chemistry, regulatory requirements, environmental considerations and aquatic impacts. There is also a brief discussion of the various alternatives to dechlorination. Case studies are given to acquaint the user with the use of the manual for the design of chlorination facilities given various site-related characteristics, such as salt versus fresh waters. Numerous graphs and tables are presented to facilitate the selection and design process. 207 references, 66 figures, 60 tables.

  16. Accelerating the deployment of offshore renewable energy technologies. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    MacDonald, Mott

    2011-02-15

    Offshore wind energy and ocean energy (i.e. wave and tidal) are at different stages of technology development and deployment, and, as such, they require different approaches for successful deployment. However, regardless of their deployment stage, these technologies may face common hurdles in their way to market competitiveness. IEA-RETD has completed a study with the overall objective to assist policy makers and project developers in a better understanding of these barriers and the specifics of offshore renewable energy and to give them practical guidelines. These include an offshore energy deployment framework, substantiated by evidence-based analyses, and recommendations for future policies design, including best practices for allocation of seafloor rights.

  17. Flexible Assembly Solar Technology (FAST) Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Toister, Elad [BrightSource Energy Inc., Jerusalem (Israel)

    2014-11-06

    The Flexible Assembly Solar Technology (FAST) project was initiated by BrightSource in an attempt to provide potential solar field EPC contractors with an effective set of tools to perform specific construction tasks. These tasks are mostly associated with heliostat assembly and installation, and require customized non-standard tools. The FAST concept focuses on low equipment cost, reduced setup time and increased assembly throughput as compared to the Ivanpah solar field construction tools.

  18. Termo technology programme. Final report 1993-1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-31

    The TERMO-technology programme was realised in 1993-1997. The aim of the programme was to promote the profitability and sustainable development of district heating by means of research and development actions. The programme included 36 research projects that were distributed to four research areas. These included heat distribution, metering, information and control systems, the economy of district heating as well as system development. The costs totaled to FIM 12 million. The programme was financed by the participating companies and the Technology Development Centre TEKES. Around eighty Finnish companies and institutions participated in the programme. In addition, the programme participated in international research cooperation in the framework of the Nordic Council of Ministers and the International Energy Agency programmes. The research area Heat Distribution included projects on rehabilitation and status control of district heating networks, pumping, thermal stresses in district heating pipes, material questions, water treatment, steam pipe systems as well as drag reducing additives in district heating water. The research area Metering, Information and Control Systems included projects on forecasts of district heating load, calibration of flow meters, heat cost allocation in buildings, control systems and their qualifications in buildings and improved cooling of district heating water in the consumer equipment. The research area Economy included projects on determination of subscribed heat demand, pricing methods of district heating, success factors of energy companies as well as long term prospects of district heating in Finland. The research area System Development included projects on changing heat loads, district cooling as well as combined heat and power production. After the TERMO programme joint efforts will be continued for the development of district heating technology. The emphasis will be to improve the feasibility of combined heat and power

  19. Technical analysis of US Army Weapons Systems and related advanced technologies of military interest. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1991-06-14

    This report summarizes the activities and accomplishments of an US Army technology security project designed to identify and develop effective policy guidelines for militarily critical technologies in specific Army systems and in broad generic technology areas of military interest, Individual systems analyses are documented in separate Weapons Systems Technical Assessments (WSTAs) and the general generic technology areas are evaluated in the Advanced Technology Assessment Reports (ATARs), However, specific details of these assessments are not addressed here, only recommendations regarding aspects of the defined approach, methodology, and format are provided and discussed.

  20. Technology review of commercial food service equipment - final report

    Energy Technology Data Exchange (ETDEWEB)

    Rahbar, S.; Krsikapa, S. [Canadian Gas Research Inst., Don Mills, ON (Canada); Fisher, D.; Nickel, J.; Ardley, S.; Zabrowski, D. [Fisher Consultants (Canada); Barker, R.F. [ed.

    1996-05-15

    Technical information on commercial gas cooking appliances was presented. This second volume provided an appliance-by-appliance comprehensive assessment of the energy performance of commercial food service equipment. Energy assessments were made for the following categories of cooking equipment: fryers, griddles, broilers, ranges, Chinese ranges, ovens, steamers, steam kettles, and braising pans. Recommendations were made for improving the energy efficiency and overall performance of gas appliances to support of the Canadian gas utilities marketing and energy conservation initiatives. 71 refs., 37 tabs., 58 figs.

  1. EMSP Final Report: Electrically Driven Technologies for Radioactive Aerosol Abatement

    Energy Technology Data Exchange (ETDEWEB)

    DePaoli, D.W.

    2003-01-22

    The purpose of this research project was to develop an improved understanding of how electrically driven processes, including electrocoalescence, acoustic agglomeration, and electric filtration, may be employed to efficiently treat problems caused by the formation of aerosols during DOE waste treatment operations. The production of aerosols during treatment and retrieval operations in radioactive waste tanks and during thermal treatment operations such as calcination presents a significant problem of cost, worker exposure, potential for release, and increased waste volume. There was anecdotal evidence in the literature that acoustic agglomeration and electrical coalescence could be used together to change the size distribution of aerosol particles in such a way as to promote easier filtration and less frequent maintenance of filtration systems. As such, those electrically driven technologies could potentially be used as remote technologies for improved treatment; however, existing theoretical models are not suitable for prediction and design. To investigate the physics of such systems, and also to prototype a system for such processes, a collaborative project was undertaken between Oak Ridge National Laboratory (ORNL) and the University of Texas at Austin (UT). ORNL was responsible for the larger-scale prototyping portion of the project, while UT was primarily responsible for the detailed physics in smaller scale unit reactors. It was found that both electrical coalescence and acoustic agglomeration do in fact increase the rate of aggregation of aerosols. Electrical coalescence requires significantly less input power than acoustic agglomeration, but it is much less effective in its ability to aggregate/coalesce aerosols. The larger-scale prototype showed qualitatively similar results as the unit reactor tests, but presented more difficulty in interpretation of the results because of the complex multi-physics coupling that necessarily occur in all larger

  2. Nanoparticle therapeutics: Technologies and methods for overcoming cancer.

    Science.gov (United States)

    Cerqueira, Brenda Brenner S; Lasham, Annette; Shelling, Andrew N; Al-Kassas, Raida

    2015-11-01

    It is anticipated that by 2030 approximately 13 million people will die of cancer. Common cancer therapy often fails due to the development of multidrug resistance (MDR), resulting in high morbidity and poor patient prognosis. Nanotechnology seeks to use drug delivery vehicles of 1-100 nm in diameter, made up of several different materials to deliver anti-cancer drugs selectively to cancer cells and potentially overcome MDR. Several technologies exist for manufacturing and functionalizing nanoparticles. When functionalized appropriately, nanoparticles have been shown to overcome several mechanisms of MDR in vivo and in vitro, reduce drug side effects and represent a promising new area of anti-cancer therapy. This review discusses the fundamental concepts of enhanced permeability and retention (EPR) effect and explores the mechanisms proposed to enhance preferential "retention" in the tumour. The overall objective of this review was to enhance our understanding in the design and development of therapeutic nanoparticles for treatment of cancer.

  3. Drug delivery system innovation and Health Technology Assessment: Upgrading from Clinical to Technological Assessment.

    Science.gov (United States)

    Panzitta, Michele; Bruno, Giorgio; Giovagnoli, Stefano; Mendicino, Francesca R; Ricci, Maurizio

    2015-11-30

    Health Technology Assessment (HTA) is a multidisciplinary health political instrument that evaluates the consequences, mainly clinical and economical, of a health care technology; the HTA aim is to produce and spread information on scientific and technological innovation for health political decision making process. Drug delivery systems (DDS), such as nanocarriers, are technologically complex but they have pivotal relevance in therapeutic innovation. The HTA process, as commonly applied to conventional drug evaluation, should upgrade to a full pharmaceutical assessment, considering the DDS complexity. This is useful to study more in depth the clinical outcome and to broaden its critical assessment toward pharmaceutical issues affecting the patient and not measured by the current clinical evidence approach. We draw out the expertise necessary to perform the pharmaceutical assessment and we propose a format to evaluate the DDS technological topics such as formulation and mechanism of action, physicochemical characteristics, manufacturing process. We integrated the above-mentioned three points in the Evidence Based Medicine approach, which is data source for any HTA process. In this regard, the introduction of a Pharmaceutics Expert figure in the HTA could be fundamental to grant a more detailed evaluation of medicine product characteristics and performances and to help optimizing DDS features to overcome R&D drawbacks. Some aspects of product development, such as manufacturing processes, should be part of the HTA as innovative manufacturing processes allow new products to reach more effectively patient bedside. HTA so upgraded may encourage resource allocating payers to invest in innovative technologies and providers to focus on innovative material properties and manufacturing processes, thus contributing to bring more medicines in therapy in a sustainable manner.

  4. Bringing Breast Cancer Technologies to Market | Poster

    Science.gov (United States)

    CCR research is recognized in novel competition to encourage the commercialization of breast cancer inventions. Editor’s note: This article was originally published in CCR Connections (Volume 8, No. 1). The Breast Cancer Startup Challenge was named one of six finalists in the HHS Innovates Award Competition, and was one of three finalists recognized by HHS Secretary Sylvia Mathews Burwell and Deputy Secretary Bill Corr. For more information on the Challenge, see previous article on the Poster website. Start-up companies are instrumental in bringing the fruits of scientific research to market. Recognizing an opportunity to bring entrepreneurial minds to bear on the diagnosis and treatment of breast cancer, the Avon Foundation for Women partnered with NCI and the Center for Advancing Innovation to launch the Breast Cancer Startup Challenge.

  5. Technology in Schools: Suggestions, Tools and Guidelines for Assessing Technology in Elementary and Secondary Education.

    Science.gov (United States)

    Ogle, Tom; Branch, Morgan; Canada, Bethann; Christmas, Oren; Clement, John; Fillion, Judith; Goddard, Ed; Loudat, N. Blair; Purwin, Tom; Rogers, Andy; Schmitt, Carl; Vinson, Mike

    This handbook is intended to facilitate the assessment of technology used to support elementary and secondary education in the United States. It is designed to help decision makers and technology users prepare, collect and assess information about whether and how technology is being used in their school systems. To make assessments that will be…

  6. 2005 Final Report: New Technologies for Future Colliders

    Energy Technology Data Exchange (ETDEWEB)

    Peter McIntyre; Al McInturff

    2005-12-31

    This document presents an annual report on our long-term R&D grant for development of new technology for future colliders. The organizing theme of our development is to develop a compact high-field collider dipole, utilizing wind-and-react Nb3Sn coil fabrication, stress man-agement, conductor optimization, bladder preload, and flux plate suppression of magnetization multipoles. The development trail for this new technology began over four years ago with the successful testing of TAMU12, a NbTi model in which we put to a first test many of the construction details of the high-field design. We have built TAMU2, a mirror-geometry dipole containing a single coil module of the 3-module set required for the 14 Tesla design. This first Nb3Sn model was built using ITER conductor which carries much less current than high-performance conductor but enables us to prove in practice our reaction bake and impregnation strategies with ‘free’ su-perconductor. TAMU2 has been shipped to LBNL for testing. Work is beginning on the construction of TAMU3, which will contain two coil modules of the 14 Tesla design. TAMU3 has a design field of 13.5 Tesla and will enable us to fully evaluate the issues of stress management that will be important to the full design. With the completion of TAMU2 and the construction of TAMU3 the Texas A&M group ‘comes of age’ in the family of superconducting magnet R&D laboratories. We have completed the phase of developing core technologies and fixtures and entered the phase of building and testing a succession of model dipoles that each build incrementally upon a proven core design.

  7. Molten carbonate fuel cell technology improvement. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1991-06-01

    This report summarizes the work performed under Department of Energy Contract DEAC21-87MC23270, ``Molten Carbonate Fuel Cell Technology Improvement.`` This work was conducted over a three year period and consisted of three major efforts. The first major effort was the power plant system study which reviewed the competitive requirements for a coal gasifier/molten carbonate fuel cell power plant, produced a conceptual design of a CG/MCFC, and defined the technology development requirements. This effort is discussed in Section 1 of the report. The second major effort involved the design and development of a new MCFC cell configuration which reduced the material content of the cell to a level competitive with competing power plants, simplified the cell configuration to make the components more manufacturable and adaptable to continuous low cost processing techniques, and introduced new-low-pressure drop flow fields for both reactant gases. The new flow fields permitted the incorporation of recirculation systems in both reactant gas systems, permitting simplified cooling techniques and the ability to operate on both natural gas and a wide variety of gasifier fuels. This cell technology improvement is discussed in Section 2. The third major effort involved the scaleup of the new cell configuration to the full-area, 8-sq-ft size and resulted in components used for a 25-kW, 20-cell stack verification test. The verification test was completed with a run of 2200 hours, exceeding the goal of 2000 hours and verifying the new cell design. TWs test, in turn, provided the confidence to proceed to a 100-kW demonstration which is the goal of the subsequent DOE program. The scaleup and stack verification tests are discussed in Sections 3, 4, 5, and 6 of this report.

  8. Advanced Thermionic Technology Program: summary report. Volume 4. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1984-10-01

    This report summarizes the progress made by the Advanced Thermionic Technology Program during the past several years. This Program, sponsored by the US Department of Energy, has had as its goal adapting thermionic devices to generate electricity in a terrestrial (i.e., combustion) environment. Volume 4 (Part E) is a highly technical discussion of the attempts made by the Program to push the state-of-the-art beyond the current generation of converters and is directed toward potential researchers engaged in this same task. These technical discussions are complemented with Appendices where appropriate.

  9. National facilities survey. Water treatment technology report No. 12 (Final)

    Energy Technology Data Exchange (ETDEWEB)

    Furukawa, D.H.

    1994-09-01

    This report is a survey of publicly and privately owned laboratories, facilities, and pilot plant equipment in the United States capable of undertaking water research and technology development. The survey was initiated by the National Water Research Institute and the Bureau of Reclamation as its first step in the development of the National Centers for Separation and Thermal Systems Research (Centers). The Centers concepts will facilitate water purification research through optimization of use of research resources, including facilities, making existing resources, facilities, and equipment available for investigators to conduct research. The survey contains information on 66 facilities in the United States.

  10. Thermionic Technology Program, fiscal year 1986: Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    Cone, V.P.; Dunlay, J.B.

    1987-12-01

    During FY 1986, the Thermionic Technology Program at Thermo Electron Corporation concentrated on advancing the development of cermet sheath insulators and additive converters. Both development efforts were based on the thermionic technology established by thermionic reactor programs during the 1960's and early 1970's. Improved sheath insulators and additive converters were fabricated during FY 1986 and delivered to Rasor Associates Incorporated, for extensive testing and evaluation. The most promising cermet fabrication process changed from dry ceramic powder coating of niobium spherical particles to the use of water-based slurries of ceramic powder and fine, irregularly shaped, niobium powder. Slurry processing is much more controlled and reproducible. The fabrication of crack-free, fully dense yttria alumina garnet (YAG) sheath insulator trilayers remains to be accomplished. Measurements of the thermal expansion of YAG indicate that the expansion mismatch with niobium (particularly from 1300 to 1500 C) may cause cracking. Limited evidence also suggests that high-temperature (1500 C and higher) reactions between YAG and niobium may also contribute to cracking. Alternative fabrication schedules need to be explored to minimize these adverse high-temperature effects. Preliminary tests indicate that alternative ceramics, such as oxide composites and aluminum oxynitride (ALON), show promise as improved sheath insulators. 41 figs., 5 tabs.

  11. Final Technical Report. Training in Building Audit Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Brosemer, Kathleen [Sault Sainte Marie Tribe of Chippewa Indians, Marie, MI (United States)

    2015-03-27

    In 2011, the Tribe proposed and was awarded the Training in Building Audit Technologies grant from the DOE in the amount of $55,748 to contract for training programs for infrared cameras, blower door technology applications and building systems. The coursework consisted of; Infrared Camera Training: Level I - Thermal Imaging for Energy Audits; Blower Door Analysis and Building-As-A-System Training, Building Performance Institute (BPI) Building Analyst; Building Envelope Training, Building Performance Institute (BPI) Envelope Professional; and Audit/JobFLEX Tablet Software. Competitive procurement of the training contractor resulted in lower costs, allowing the Tribe to request and receive DOE approval to additionally purchase energy audit equipment and contract for residential energy audits of 25 low-income Tribal Housing units. Sault Tribe personnel received field training to supplement the classroom instruction on proper use of the energy audit equipment. Field experience was provided through the second DOE energy audits grant, allowing Sault Tribe personnel to join the contractor, Building Science Academy, in conducting 25 residential energy audits of low-income Tribal Housing units.

  12. Decision Gate Process for Assessment of a NASA Technology Development Portfolio

    Science.gov (United States)

    Kohli, Rajiv; Fishman, Julianna L.; Hyatt, Mark J.

    2012-01-01

    The NASA Dust Management Project (DMP) was established to provide technologies (to Technology Readiness Level (TRL) 6) required to address adverse effects of lunar dust to humans and to exploration systems and equipment, to reduce life cycle cost and risk, and to increase the probability of sustainable and successful lunar missions. The technology portfolio of DMP consisted of different categories of technologies whose final product was either a technology solution in itself, or one that contributes toward a dust mitigation strategy for a particular application. A Decision Gate Process (DGP) was developed to assess and validate the achievement and priority of the dust mitigation technologies as the technologies progress through the development cycle. The DGP was part of continuous technology assessment and was a critical element of DMP risk management. At the core of the process were technology-specific criteria developed to measure the success of each DMP technology in attaining the technology readiness levels assigned to each decision gate. The DGP accounts for both categories of technologies and qualifies the technology progression from technology development tasks to application areas. The process provided opportunities to validate performance, as well as to identify non-performance in time to adjust resources and direction. This paper describes the overall philosophy of the DGP and the methodology for implementation for DMP, and describes the method for defining the technology evaluation criteria. The process is illustrated by example of an application to a specific DMP technology.

  13. GRANITE CUTTING WASTE: TECHNOLOGICAL INNOVATION FOR THE FINAL DESTINATION

    Directory of Open Access Journals (Sweden)

    Joner Oliveira Alves

    2015-06-01

    Full Text Available The granite processing market is one of the most promising business areas of the mineral sector, with an average growth of the world production of about 6% per year. The granite extraction generates residues in the form of powder rock of 20-25 wt.% of the total benefited. The granite dust must be carefully managed since it can cause siltation of rivers and human health risks. This paper presents two routes for the final destination of this waste: the vitrification process aiming the production of fibers for thermo-acoustic insulation, and the magnetic separation in order to recover the steel grit. Results showed that the forms of treatments presented are economically and ecologically viable since they represent a cost reduction in the waste disposal, and also provide the production of new materials with commercial value.

  14. Technology-Based Classroom Assessments: Alternatives to Testing

    Science.gov (United States)

    Salend, Spencer J.

    2009-01-01

    Although many teachers are using new technologies to differentiate instruction and administer tests, educators are also employing a range of technology-based resources and strategies to implement a variety of classroom assessments as alternatives to standardized and teacher-made testing. Technology-based classroom assessments focus on the use of…

  15. 75 FR 79354 - Assessment Technology Standards Request for Information (RFI)

    Science.gov (United States)

    2010-12-20

    ..., virtual worlds, mobile devices, and simulations. 3.2.28 Accessibility. How do technology standards ensure... Assessment Technology Standards Request for Information (RFI) AGENCY: Office of Innovation and Improvement, U... pertaining to assessment technology standards. SUMMARY: The purpose of this RFI is to collect...

  16. Hellsgate Winter Range : Wildlife Mitigation Project. Final Environmental Assessment.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1995-03-01

    Bonneville Power Administration (BPA) proposes to fund the Hellsgate Winter Range Wildlife Mitigation Project (Project) in a cooperative effort with the Colville Confederated Tribes and the Bureau of Indian Affairs (BIA). The proposed action would allow the sponsors to secure property and conduct wildlife management activities within the boundaries of the Colville Indian Reservation. This Final Environmental Assessment (EA) examines the potential environmental effects of acquiring and managing property for wildlife and wildlife habitat within a large project area. This area consists of several separated land parcels, of which 2,000 hectares (4,943 acres) have been purchased by BPA and an additional 4,640 hectares (11,466 acres) have been identified by the Colville Confederated Tribes for inclusion in the Project. Four proposed activities (habitat protection, habitat enhancement, operation and maintenance, and monitoring and evaluation) are analyzed. The proposed action is intended to meet the need for mitigation of wildlife and wildlife habitat that was adversely affected by the construction of Grand Coulee and Chief Joseph Dams and their reservoirs.

  17. Blue Creek Winter Range : Wildlife Mitigation Project : Final Environmental Assessment.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration; United States. Bureau of Indian Affairs; Spokane Tribe of the Spokane Reservation, Washington

    1994-11-01

    Bonneville Power Administration (BPA) proposes to fund that portion of the Washington Wildlife Agreement pertaining to the Blue Creek Winter Range Wildlife Mitigation Project (Project) in a cooperative effort with the Spokane Tribe, Upper Columbia United Tribes, and the Bureau of Indian Affairs (BIA). If fully implemented, the proposed action would allow the sponsors to protect and enhance 2,631 habitat units of big game winter range and riparian shrub habitat on 2,185 hectares (5,400 acres) of Spokane Tribal trust lands, and to conduct long term wildlife management activities within the Spokane Indian Reservation project area. This Final Environmental Assessment (EA) examines the potential environmental effects of securing land and conducting wildlife habitat enhancement and long term management activities within the boundaries of the Spokane Indian Reservation. Four proposed activities (habitat protection, habitat enhancement, operation and maintenance, and monitoring and evaluation) are analyzed. The proposed action is intended to meet the need for mitigation of wildlife and wildlife habitat adversely affected by the construction of Grand Coulee Dam and its reservoir.

  18. Aptamers: A Feasible Technology in Cancer Immunotherapy

    Directory of Open Access Journals (Sweden)

    M. M. Soldevilla

    2016-01-01

    Full Text Available Aptamers are single-chained RNA or DNA oligonucleotides (ODNs with three-dimensional folding structures which allow them to bind to their targets with high specificity. Aptamers normally show affinities comparable to or higher than that of antibodies. They are chemically synthesized and therefore less expensive to manufacture and produce. A variety of aptamers described to date have been shown to be reliable in modulating immune responses against cancer by either blocking or activating immune receptors. Some of them have been conjugated to other molecules to target the immune system and reduce off-target side effects. Despite the success of first-line treatments against cancer, the elevated number of relapsing cases and the tremendous side effects shown by the commonly used agents hinder conventional treatments against cancer. The advantages provided by aptamers could enhance the therapeutic index of a given strategy and therefore enhance the antitumor effect. Here we recapitulate the provided benefits of aptamers with immunomodulatory activity described to date in cancer therapy and the benefits that aptamer-based immunotherapy could provide either alone or combined with first-line treatments in cancer therapy.

  19. Aptamers: A Feasible Technology in Cancer Immunotherapy.

    Science.gov (United States)

    Soldevilla, M M; Villanueva, H; Pastor, F

    2016-01-01

    Aptamers are single-chained RNA or DNA oligonucleotides (ODNs) with three-dimensional folding structures which allow them to bind to their targets with high specificity. Aptamers normally show affinities comparable to or higher than that of antibodies. They are chemically synthesized and therefore less expensive to manufacture and produce. A variety of aptamers described to date have been shown to be reliable in modulating immune responses against cancer by either blocking or activating immune receptors. Some of them have been conjugated to other molecules to target the immune system and reduce off-target side effects. Despite the success of first-line treatments against cancer, the elevated number of relapsing cases and the tremendous side effects shown by the commonly used agents hinder conventional treatments against cancer. The advantages provided by aptamers could enhance the therapeutic index of a given strategy and therefore enhance the antitumor effect. Here we recapitulate the provided benefits of aptamers with immunomodulatory activity described to date in cancer therapy and the benefits that aptamer-based immunotherapy could provide either alone or combined with first-line treatments in cancer therapy.

  20. Alternative control technology document for bakery oven emissions. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Sanford, C.W.

    1992-12-01

    The document was produced in response to a request by the baking industry for Federal guidance to assist in providing a more uniform information base for State decision-making with regard to control of bakery oven emissions. The information in the document pertains to bakeries that produce yeast-leavened bread, rolls, buns, and similar products but not crackers, sweet goods, or baked foodstuffs that are not yeast leavened. Information on the baking processes, equipment, operating parameters, potential emissions from baking, and potential emission control options are presented. Catalytic and regenerative oxidation are identified as the most appropriate existing control technologies applicable to VOC emissions from bakery ovens. Cost analyses for catalytic and regenerative oxidation are included. A predictive formula for use in estimating oven emissions has been derived from source tests done in junction with the development of the document. Its use and applicability are described.

  1. DNA sequencing technology, walking with modular primers. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Ulanovsky, L.

    1996-12-31

    The success of the Human Genome Project depends on the development of adequate technology for rapid and inexpensive DNA sequencing, which will also benefit biomedical research in general. The authors are working on DNA technologies that eliminate primer synthesis, the main bottleneck in sequencing by primer walking. They have developed modular primers that are assembled from three 5-mer, 6-mer or 7-mer modules selected from a presynthesized library of as few as 1,000 oligonucleotides ({double_bond}4, {double_bond}5, {double_bond}7). The three modules anneal contiguously at the selected template site and prime there uniquely, even though each is not unique for the most part when used alone. This technique is expected to speed up primer walking 30 to 50 fold, and reduce the sequencing cost by a factor of 5 to 15. Time and expensive will be saved on primer synthesis itself and even more so due to closed-loop automation of primer walking, made possible by the instant availability of primers. Apart from saving time and cost, closed-loop automation would also minimize the errors and complications associated with human intervention between the walks. The author has also developed two additional approaches to primer-library based sequencing. One involves a branched structure of modular primers which has a distinctly different mechanism of achieving priming specificity. The other introduces the concept of ``Differential Extension with Nucleotide Subsets`` as an approach increasing priming specificity, priming strength and allowing cycle sequencing. These approaches are expected to be more robust than the original version of the modular primer technique.

  2. Cancer Risk Assessment: Should New Science be Applied? Workgroup summary

    Energy Technology Data Exchange (ETDEWEB)

    Richard J. Bull; Antone L. Brooks

    2002-12-15

    OAK-B135 A symposium discussing the implications of certain phenomena observed in radiation biology for cancer risk assessment in general. In July of 2002 a workshop was convened that explored some of the intercellular phenomena that appear to condition responses to carcinogen exposure. Effects that result from communication between cells that appear to either increase the sphere of damage or to modify the sensitivity of cells to further damage were of particular interest. Much of the discussion focused on the effects of ionizing radiation that were transmitted from cells directly hit to cells not receiving direct exposure to radiation (bystander cells). In cell culture, increased rates of mutation, chromosomal aberration, apoptosis, genomic instability, and decreased clonogenic survival have all been observed in cells that have experienced no direct radiation. In addition, there is evidence that low doses of radiation or certain chemicals give rise to adaptive responses in which the treated cells develop resistance to the effects of high doses given in subsequent exposures. Data were presented at the workshop indicating that low dose exposure of animals to radiation and some chemicals frequently reduces the spontaneous rate of mutation in vitro and tumor responses in vivo. Finally, it was concluded that considerable improvement in understanding of how genetic variation may modify the impact of these phenomena is necessary before the risk implications can be fully appreciated. The workshop participants discussed the substantive challenge that these data present with respect to simple linear methodologies that are currently used in cancer risk assessment and attempted to identify broad strategies by which these phenomena may start to be used to refine cancer risk assessment methods in the future.

  3. Technology review of commercial food service equipment - final report

    Energy Technology Data Exchange (ETDEWEB)

    Rahbar, S.; Krsikapa, S. [Canadian Gas Research Inst., Don Mills, ON (Canada); Fisher, D.; Nickel, J.; Ardley, S.; Zabrowski, D. [Fisher Consultants (Canada); Barker, R.F. [ed.

    1996-05-15

    Market and technical information on gas fired equipment used in the commercial food service sector in Canada and in each province or territory was presented. Results of a market study and technology review were integrated to establish energy consumption and energy saving potential in this sector. Eight categories of commercial cooking appliances were studied. They were: fryers, griddles, broilers, ranges, ovens, tilting skillets, steam kettles and steamers. Focus was on gas fired appliances, although electric appliances were also included. The total energy consumption of the appliances was estimated at 76,140.37 GBtu in 1994. Gas appliances accounted for 63 per cent of the total inventory and consumed 83 per cent of the total energy used. Cooking energy efficiencies for the gas fired commercial cooking equipment ranged from 10 per cent to 60 per cent. The electric appliances had cooking energy efficiencies ranging from 35 per cent to 95 per cent. A list of recommendations were made for the many opportunities to introduce higher efficiency commercial cooking appliances, essential to slow down or to stabilize the energy consumption of cooking appliances over the next decade. 66 refs., 14 tabs., 18 figs.

  4. Thermionic Technology Program: A, Insulator test and evaluation: Final report

    Energy Technology Data Exchange (ETDEWEB)

    Dobson, J.C.; Witt, T.

    1987-11-30

    The Thermionic Technology Program (TTP) consisted of two major efforts, evaluation of insulators and evaluation of thermionic converters. This report details the work performed on the insulator phase of the program. Efforts were made to better understand the mechanisms involved in the electrochemistry of insulators at elevated temperatures by modelling the ionic transport through the various layers of the insulator package. Although rigorous analytic solutions could not be obtained owing to a lack of detailed data, a simplified model indicated that alumina should not fail by depletion of aluminum for thousands of years, whereas calculations for yttria revealed a far more rapid depletion of oxygen and consequently earlier failure. Methods for microscopic and electrical testing of cylindrical insulator samples were developed, and an improved test oven design was initiated. Testing of alumina/niobium cermet samples revealed rapid failure contrary to the theoretical predictions for alumina. Large discrepancies in the initial conduction activation energy among the various samples suggested that different mechanisms could have controlled the conduction and hence the failure in different samples, although all had undergone nominally identical processing. The short lifetimes reveal how rapidly ambient conditions in thermionic power conversion can degrade the performance of insulating oxides. It was concluded that minor dopants could have been responsible for the early breakdowns. Thus, high purity materials with precise quality control will be necessary for trilayer package development. 35 refs., 28 figs., 5 tabs.

  5. Technological Innovations in Surgical Approach for Thyroid Cancer

    Directory of Open Access Journals (Sweden)

    Brian Hung-Hin Lang

    2010-01-01

    Full Text Available Over the last decade, surgeons have witnessed dramatic changes in surgical practice as a result of the introduction of new technological advancement. Some of these changes include refinement of techniques in thyroid cancer surgery. The development of various endoscopic thyroidectomy techniques, the addition of the da Vinci robot, and the use of operative adjuncts in thyroid surgery, such as intraoperative neuromonitoring and quick intraoperative parathyroid hormone, have made thyroid cancer surgery not only safer and better accepted by patients with thyroid cancer but also offer them more surgical treatment options.

  6. CRADA Final Report, 2011S003, Faraday Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Faraday Technologies

    2012-12-12

    This Phase I SBIR program addressed the need for an improved manufacturing process for electropolishing niobium RF superconducting cavities for the International Linear Collider (ILC). The ILC is a proposed particle accelerator that will be used to gain a deeper understanding of the forces of energy and matter by colliding beams of electrons and positrons at nearly the speed of light. The energy required for this to happen will be achieved through the use of advanced superconducting technology, specifically ~16,000 RF superconducting cavities operating at near absolute zero. The RF superconductor cavities will be fabricated from highly pure Nb, which has an extremely low surface resistance at 2 Kelvin when compared to other materials. To take full advantage of the superconducting properties of the Nb cavities, the inner surface must be a) polished to a microscale roughness < 0.1 µm with removal of at least 100 µm of material, and b) cleaned to be free of impurities that would degrade performance of the ILC. State-of-the-art polishing uses either chemical polishing or electropolishing, both of which require hydrofluoric acid to achieve breakdown of the strong passive film on the surface. In this Phase I program, Faraday worked with its collaborators at the Thomas Jefferson National Accelerator Facility (JLab) to demonstrate the feasibility of an electropolishing process for pure niobium, utilizing an environmentally benign alternative to chemical or electrochemical polishing electrolytes containing hydrofluoric acid. Faraday utilized a 31 wt% aqueous sulfuric acid solution (devoid of hydrofluoric acid) in conjunction with the FARADAYICSM Process, which uses pulse/pulse reverse fields for electropolishing, to demonstrate the ability to electropolish niobium to the desired surface finish. The anticipated benefits of the FARADAYICSM Electropolishing process will be a simpler, safer, and less expensive method capable of surface finishing high purity niobium cavities

  7. 78 FR 28873 - Availability of Final Environmental Assessment and Finding of No Significant Impact for the...

    Science.gov (United States)

    2013-05-16

    ... of availability. SUMMARY: This notice announces the availability of a Final Environmental Assessment (Final EA) which examines the reasonably foreseeable environmental impacts and socio-economic impacts of... SECURITY Coast Guard Availability of Final Environmental Assessment and Finding of No Significant...

  8. Space Launch System Upper Stage Technology Assessment

    Science.gov (United States)

    Holladay, Jon; Hampton, Bryan; Monk, Timothy

    2014-01-01

    discussed in light of the various missions. For each mission there are several trajectory options and each will be discussed in terms of delta-v required and transit duration. Each propulsion system will be modeled, sized, and judged based on their applicability to the whole range of beyond LEO missions. Criteria for scoring will include the resulting dry mass of the stage, resulting propellant required, time to destination, and an assessment of key enabling technologies. In addition to the larger metrics, this paper will present the results of several coupled sensitivity studies. The ultimate goals of these tools and studies are to provide NASA with the most mass-, technology-, and cost-effective in-space stage for its future exploration missions.

  9. Clinical and technological transition in breast cancer

    OpenAIRE

    Poortmans, Philip; Marsiglia, Hugo; de las Heras, Manuel; Algara, Manuel

    2013-01-01

    This article is a summary of the conference “Clinical and technological transition in breast cancer” that took place in the Congress of the Spanish Society of Radiation Oncology, placed in Vigo (Spain) on June 21, 2013. Hugo Marsiglia and Philip Poortmanns were the speakers, the first discussed about “Clinical and technological transition” and the second about “EORTC clinical trials and protocols”.

  10. Texas A&M University Industrial Assessment Center Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Heffington, Warren M.; Eggebrecht, James A.

    2007-02-24

    This project benefited the public by assisting manufacturing plants in the United States to save costly energy resources and become more profitable. Energy equivalent to over 75,000 barrels of oil was conserved. The Texas A&M University Industrial Assessment Center (IAC) visited 96 manufacturing plants and spent 101 days in those plants during the contract period from August 9, 2002, through November 30, 2006. Recommended annual energy savings for manufacturers were 37,400,000 kWh (127,600 MMBtu—site basis) of electricity and 309,000 MCF (309,000 MMBtu) of natural gas. Each manufacturer subsequently was surveyed, and based on these surveys reportedly implemented 79% of the electricity savings and 36% of the natural gas savings for an overall energy savings of 48% of recommended. Almost 800 (798) projects were recommended to manufacturers, and they accomplished two-thirds of the projects. Cost savings recommended were $12.3 million and implemented savings were $5.7 million or 47%. During the contract period our average time between site visit and report submittal averaged 46 days; and decreased from 48 days in 2003 to 44 days in 2006. Serving clients well and promptly has been a priority. We visited five ESA overflow clients during FY 06. The Texas A&M University IAC pioneered the presentation of air pollution information in reports, and includes NOx and CO2 reductions due to energy savings in all reports. We also experimented with formal PowerPoint BestPractices presentations called Lunchtime/Showtime in each plant and with delivering electronic versions of the report. During the period of the contract, the director served on the Texas Industries of the Future (IOF) Refining and Chemicals Committee, which oversaw the showcases in 2003 and 2006. The assistant director was the Executive Director of the International Energy Technology Conference held annually. The director and assistant director became qualified specialists in the Process Heating Assessment Scoping

  11. Development of Seismic Safety Assessment Technology for Containment Structure

    Energy Technology Data Exchange (ETDEWEB)

    Jang, J.B.; Suh, Y.P.; Lee, J.R. [Korea Electric Power Research Institute, Taejon (Korea)

    2002-07-01

    This final report is made based on the research results of seismic analysis and seismic margin assessment field, carried out during 3rd stage ('01.4.1{approx}'02.3.31) under financial support of MOST(Ministry of Science and Technology). The objective of this research is to develop the soil - structure interaction analysis technique with high reliability, the main research subjects, performed during 3rd stage are as follows. 1) Preparation of user's guide manual for SSI analysis with high accuracy. 2) Sensitivity analysis of effective shear strain and seismic input motion. 3) Database construction of Hualien earthquake recorded data. (author). 21 refs., 27 figs., 2 tabs.

  12. Application of organism weak magnetic field analytic technology in psychological assessment of cancer patients%生物体微弱磁场技术在评估肿瘤患者心理状况中的应用

    Institute of Scientific and Technical Information of China (English)

    王京; 彭清涛; 王育兵; 夏本立

    2012-01-01

    [ Objective]To understand the mental status of cancer patients, and provide reference for developing psychological interventions. [Methods] A total of 165 cancer patients were selected by clustered sampling, the morning urine testing of 165 cancer patients was carried out by organism weak magnetic field analytic machine with ltime/d and continuous measuring for 5 d, which obtained 27 indexes, such as pressure, sleep, emotions, etc. [Results] In all these tested indexes, emotional stability, pressure stability and sleep were the most prominent, their abnormal rates were 93.94% , 95.00% ,87.88%. Comparing the above indexes, the differences were significant (P<0.05). [ Conclusion] In general, the mental status of the cancer patients is extremely insta-ble, pressure-proof is lower and sleep quality is bad. The cancer patients' mental status can be evaluated relative quantitatively by organism weak magnetic field analytic technology, which can provide the reference for further study of mental demand of cancer patients and effective mental intervention.%目的 了解肿瘤患者心理状况,为制定心理干预措施提供依据.方法 采用整群抽样方法,抽取肿瘤患者165名,利用生物体微弱磁场检测技术对肿瘤患者晨尿进行检测,1次/d,连续检测5d,以对压力、睡眠、情绪等27项心理指标进行测评.结果 在所检测的心理指标中,情绪稳定性、压力稳定性、睡眠3项心理指标最为突出,异常率分别为93.94%、95.00%、87.88%;以上3项心理指标相比较,其差异有统计学意义(P<0.05).结论 肿瘤患者总体的心理情绪极不稳定,耐压能力下降,睡眠质量差.生物体微弱磁场检测技术能够对肿瘤患者的心理状态指标进行相对量化的评估,可为进一步研究肿瘤患者的心理需求及进行心理干预提供依据.

  13. Life cycle assessment of emerging technologies

    DEFF Research Database (Denmark)

    Valsasina, Lucia; Pizzol, Massimo; Smetana, Sergiy;

    2017-01-01

    Abstract Milk is becoming a key food commodity as population grows and demand increases. The treatment of milk to extend its shelf life is thus an important step in avoiding losses and optimizing resource use. The drawbacks of the most common treatments for shelf stable milk are the loss of nutri......Abstract Milk is becoming a key food commodity as population grows and demand increases. The treatment of milk to extend its shelf life is thus an important step in avoiding losses and optimizing resource use. The drawbacks of the most common treatments for shelf stable milk are the loss...... shelf life. A life cycle assessment was performed comparing this emerging technology to the common thermal treatment: indirect ultra-high temperature sterilisation combined with non-aseptic homogenisation. The results show that high-pressure based processing has a lower environmental burden compared...... to the high-temperature based processing, already at pilot-scale, and this difference is primarily due to the lower electricity consumption. Additionally, upscaling considerations were made using power laws and scenario analysis to simulate future full-scale applications of UHPH. The upscaling shows...

  14. History of healthcare technology assessment in Japan.

    Science.gov (United States)

    Hisashige, Akinori

    2009-07-01

    There has been a rapid growth of healthcare technology assessment (HTA) activities among health service researchers and physicians in Japan in the younger generation since the mid-1980s. HTA has become visible since the Ministry of Health, Labor, and Welfare (MHLW) set up the several committees related to HTA in the late 1990s. The MHLW had to participate in regulatory and administrative reform, coping with the serious economic stagnation since 1991, following the economic recession in the 1980s. However, HTA has not been developed as expected. The most important failure is that the application of HTA to health policy has been neglected by the MHLW. Only application to clinical practice has been implemented by developing evidence-based clinical practice guidelines. The MHLW had the main aim of containing costs by reducing excess or useless healthcare services through guidelines, rather than to implement a radical reform. Without a central organization for HTA, several researchers have still continued to do HTA studies, but most researchers and physicians promoting HTA have been moved into diverse related areas. Ultimately, increasing efficiency may be the only way of reconciling rising demands for health care with public financing constraints. Therefore, the reconsideration and reorganization of HTA, which covers not only healthcare services but also the healthcare system as a whole, is becoming an urgent matter for healthcare reform.

  15. Technological advances in radiotherapy of rectal cancer

    DEFF Research Database (Denmark)

    Appelt, Ane L; Sebag-Montefiore, David

    2016-01-01

    PURPOSE OF REVIEW: This review summarizes the available evidence for the use of modern radiotherapy techniques for chemoradiotherapy for rectal cancer, with specific focus on intensity-modulated radiotherapy (IMRT) and volumetric arc therapy (VMAT) techniques. RECENT FINDINGS: The dosimetric....... Overall results are encouraging, as toxicity levels - although varying across reports - appear lower than for 3D conformal radiotherapy. Innovative treatment techniques and strategies which may be facilitated by the use of IMRT/VMAT include simultaneously integrated tumour boost, adaptive treatment...

  16. Developing an instrument for assessing students' concepts of the nature of technology

    Science.gov (United States)

    Liou, Pey-Yan

    2015-05-01

    Background:The nature of technology has been rarely discussed despite the fact that technology plays an essential role in modern society. It is important to discuss students' concepts of the nature of technology, and further to advance their technological literacy and adaptation to modern society. There is a need to assess high school students' concepts of the nature of technology. Purpose:This study aims to engage in discourse on students' concepts of the nature of technology based on a proposed theoretical framework. Moreover, another goal is to develop an instrument for measuring students' concepts of the nature of technology. Sample:Four hundred and fifty-five high school students' perceptions of technology were qualitatively analyzed. Furthermore, 530 students' responses to a newly developed questionnaire were quantitatively analyzed in the final test. Design and method:First, content analysis was utilized to discuss and categorize students' statements regarding technology and its related issues. The Student Concepts of the Nature of Technology Questionnaire was developed based on the proposed theoretical framework and was supported by the students' qualitative data. Finally, exploratory factor analysis and reliability analysis were applied to determine the structure of the items and the internal consistency of each scale. Results:Through a process of instrument development, the Student Concepts of the Nature of Technology Questionnaire was shown to be a valid and reliable tool for measuring students' concepts of the nature of technology. This newly developed questionnaire is composed of 29 items in six scales, namely 'technology as artifacts,' 'technology as an innovation change,' 'the current role of technology in society,' 'technology as a double-edged sword,' 'technology as a science-based form,' and 'history of technology.' Conclusions:The Student Concepts of the Nature of Technology Questionnaire has been confirmed as a reasonably valid and reliable

  17. HPCC technology awareness program: Improved economic competitiveness through technology awareness, transfer and application. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1994-04-01

    A need has been defined by Congress for the DOE National Laboratories to participate in various dual use and technology transfer programs. This requirement has spawned several technology transfer approaches at the DOE laboratories. These programs are designed to encourage large and small business to bring their problems and needs forward, and to allow the labs to transfer effective high performance computing technology to the commercial marketplace. This IG Technologies grant from the DOE was undertaken to address the issues and problems associated with technology transfer between the DOE National Laboratories and commercial industry. The key focus is to gain an understanding of how DOE and industry independently and collectively view the requirements and the missing elements that could allow DOE to facilitate HPCC technology transfer. At issue is HPCC Technology Transfer for the High Performance Computing industry and its relationship to the DOE National Laboratories. Several observations on this are addressed. The issue of a ``Technology Utilization Gap`` between the National Laboratories and Independent Software Vendors is discussed. This study addressed the HPCC Technology Transfer plans of all six DOE National Labs. Study team members briefed numerous industrial users of HPCC technology as to the feasibility of technology transfer for various applications. Significant findings of the effort are that the resistance to technology transfer is much higher than anticipated for both the National Labs and industry. Also, HPCC Technology Transfer is observed to be a large company`s dominion. Small businesses have a difficult time in addressing the requirements of technology transfer using Cooperative Research and Development Agreements (CRADA`s). Large businesses and the DOE National Labs however, often have requirements and objectives which are at cross purposes, making effective technology transfer difficult.

  18. 78 FR 110 - Supplemental Record of Decision; Final Supplementary Risk Assessment for the Boston University...

    Science.gov (United States)

    2013-01-02

    ... Assessment for the Boston University National Emerging Infectious Diseases Laboratories Responsible Official... (NIH), has decided, after completion of a Final Supplementary Risk Assessment and a thorough consideration of public comments on the Draft and Final Supplementary Risk Assessment, to implement the...

  19. Disparities in Cancer Genetic Risk Assessment and Testing.

    Science.gov (United States)

    Underhill, Meghan L; Jones, Tarsha; Habin, Karleen

    2016-07-01

    Scientific and technologic advances in genomics have revolutionized genetic counseling and testing, targeted therapy, and cancer screening and prevention. Among younger women, African American and Hispanic women have a higher rate of cancers that are associated with hereditary cancer risk, such as triple-negative breast cancer, which is linked to poorer outcomes. Therefore, genetic testing is particularly important in diverse populations. Unfortunately, all races and ethnic groups are not well represented in current genetic testing practices, leading to disparities in cancer prevention and early detection.

  20. Novel technologies and emerging biomarkers for personalized cancer immunotherapy.

    Science.gov (United States)

    Yuan, Jianda; Hegde, Priti S; Clynes, Raphael; Foukas, Periklis G; Harari, Alexandre; Kleen, Thomas O; Kvistborg, Pia; Maccalli, Cristina; Maecker, Holden T; Page, David B; Robins, Harlan; Song, Wenru; Stack, Edward C; Wang, Ena; Whiteside, Theresa L; Zhao, Yingdong; Zwierzina, Heinz; Butterfield, Lisa H; Fox, Bernard A

    2016-01-01

    The culmination of over a century's work to understand the role of the immune system in tumor control has led to the recent advances in cancer immunotherapies that have resulted in durable clinical responses in patients with a variety of malignancies. Cancer immunotherapies are rapidly changing traditional treatment paradigms and expanding the therapeutic landscape for cancer patients. However, despite the current success of these therapies, not all patients respond to immunotherapy and even those that do often experience toxicities. Thus, there is a growing need to identify predictive and prognostic biomarkers that enhance our understanding of the mechanisms underlying the complex interactions between the immune system and cancer. Therefore, the Society for Immunotherapy of Cancer (SITC) reconvened an Immune Biomarkers Task Force to review state of the art technologies, identify current hurdlers, and make recommendations for the field. As a product of this task force, Working Group 2 (WG2), consisting of international experts from academia and industry, assembled to identify and discuss promising technologies for biomarker discovery and validation. Thus, this WG2 consensus paper will focus on the current status of emerging biomarkers for immune checkpoint blockade therapy and discuss novel technologies as well as high dimensional data analysis platforms that will be pivotal for future biomarker research. In addition, this paper will include a brief overview of the current challenges with recommendations for future biomarker discovery.

  1. Screening Technologies for Target Identification in Pancreatic Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Michl, Patrick, E-mail: michlp@med.uni-marburg.de; Ripka, Stefanie; Gress, Thomas; Buchholz, Malte [Department of Gastroenterology and Endocrinology, University Hospital, Philipps-University Marburg, Baldinger Strasse, D-35043 Marburg (Germany)

    2010-12-29

    Pancreatic cancer exhibits an extraordinarily high level of resistance to almost any kind of systemic therapy evaluated in clinical trials so far. Therefore, the identification of novel therapeutic targets is urgently required. High-throughput screens have emerged as an important tool to identify putative targets for diagnosis and therapy in an unbiased manner. More than a decade ago, microarray technology was introduced to identify differentially expressed genes in pancreatic cancer as compared to normal pancreas, chronic pancreatitis and other cancer types located in close proximity to the pancreas. In addition, proteomic screens have facilitated the identification of differentially secreted proteins in body fluids of pancreatic cancer patients, serving as possible biomarkers. Recently, RNA interference-based loss-of-function screens have been used to identify functionally relevant genes, whose knock-down has impact on pancreatic cancer cell viability, thereby representing potential new targets for therapeutic intervention. This review summarizes recent results of transcriptional, proteomic and functional screens in pancreatic cancer and discusses potentials and limitations of the respective technologies as well as their impact on future therapeutic developments.

  2. Empowerment of cancer survivors through information technology: an integrative review

    NARCIS (Netherlands)

    Groen, W.G.; Kuijpers, W.; Oldenburg, H.S.A.; Wouters, M.W.J.M.; Aaronson, N.K.; van Harten, W.H.

    2015-01-01

    Background: Patient empowerment may be an effective approach to strengthen the role of cancer survivors and to reduce the burden on health care. However, it is not well conceptualized, notably in oncology. Furthermore, it is unclear to what extent information technology (IT) services can contribute

  3. Empowerment of Cancer Survivors Through Information Technology: An Integrative Review

    NARCIS (Netherlands)

    Groen, Wim G.; Kuijpers, Wilma; Oldenburg, Hester S.A.; Wouters, Michel W.J.M.; Aaronson, Neil K.; Harten, van Wim H.

    2015-01-01

    Background: Patient empowerment may be an effective approach to strengthen the role of cancer survivors and to reduce the burden on health care. However, it is not well conceptualized, notably in oncology. Furthermore, it is unclear to what extent information technology (IT) services can contribute

  4. Establishment of the temporary certification program for health information technology. Final rule.

    Science.gov (United States)

    2010-06-24

    This final rule establishes a temporary certification program for the purposes of testing and certifying health information technology. This final rule is established under the authority granted to the National Coordinator for Health Information Technology (the National Coordinator) by section 3001(c)(5) of the Public Health Service Act (PHSA), as added by the Health Information Technology for Economic and Clinical Health (HITECH) Act. The National Coordinator will utilize the temporary certification program to authorize organizations to test and certify Complete Electronic Health Records (EHRs) and/or EHR Modules, thereby making Certified EHR Technology available prior to the date on which health care providers seeking incentive payments available under the Medicare and Medicaid EHR Incentive Programs may begin demonstrating meaningful use of Certified EHR Technology.

  5. Appalachian Rivers II Conference: Technology for Monitoring, Assessing, and Restoring Streams, Rivers, and Watersheds

    Energy Technology Data Exchange (ETDEWEB)

    None available

    1999-07-29

    On July 28-29, 1999, the Federal Energy Technology Center (FETC) and the WMAC Foundation co-sponsored the Appalachian Rivers II Conference in Morgantown, West Virginia. This meeting brought together over 100 manufacturers, researchers, academicians, government agency representatives, watershed stewards, and administrators to examine technologies related to watershed assessment, monitoring, and restoration. Sessions included presentations and panel discussions concerning watershed analysis and modeling, decision-making considerations, and emerging technologies. The final session examined remediation and mitigation technologies to expedite the preservation of watershed ecosystems.

  6. Estuarine and Riverine Areas Final Programmatic Environmental Assessment

    Science.gov (United States)

    2004-06-25

    the surface during the rainy season. Rare plants include southern milkweed , white-top pitcher plant, sweet pitcherplant, Chapman’s butterwort, and... cancer causing, and adversely affects reproduction, liver and thyroid function, disease resistance. Plants and animals may bioconcentrate lead but

  7. GENE TECHNOLOGY: A NEW WAY TO TREAT CANCER

    Directory of Open Access Journals (Sweden)

    Prajapati P M.

    2012-06-01

    Full Text Available Gene therapy is the process of introducing genetic material RNA or DNA into a person's cells to fight disease. Gene therapy treats disease by either replacing damaged or missing genes with normal ones, or by providing new genes. The concept of gene therapy was born more than thirty years ago; however, new technology is opening the door to dramatically new possibilities in the treatment of cancers of all kinds. The long-term goal of cancer gene therapy is to develop treatments that attack only cancer cells, thereby eliminating adverse effects on the body and improving the possibility to cure disease. Gene therapy may someday soon make cancer a manageable disease with nominal side effects to the patients. Furthermore, since gene therapy has potential for other diseases such as cystic fibrosis, hemophilia, sickle-cell anemia, muscular dystrophy and Parkinson's, the value of research and discovery has broad applications.

  8. Assessments of emerging science and technologies: Mapping the landscape

    NARCIS (Netherlands)

    Forsberg, E.M.; Thorstensen, E.; Nielsen, R.O.; Bakker, de E.

    2014-01-01

    This paper presents comparative work from the EST-Frame project on technology appraisal. It focuses on studies of 'advisory domains' (more or less distinct traditions for assessment of technologies, such as risk analysis, foresight and ethical assessments). The purpose of the study was to increase t

  9. How to make participatory technology assessment in agriculture more 'participatory'

    DEFF Research Database (Denmark)

    Tavella, Elena

    2016-01-01

    the cultivation of new GM plants in Denmark. Furthermore, through this illustration, the term Participatory Technology Assessment (PTA) is redefined, thereby suggesting two additional aspects to assessing new technologies – following and evaluating policy making – to be considered in the conduct of PTA....

  10. Final height and body mass index among adult survivors of childhood brain cancer: childhood cancer survivor study.

    Science.gov (United States)

    Gurney, James G; Ness, Kirsten K; Stovall, Marilyn; Wolden, Suzanne; Punyko, Judy A; Neglia, Joseph P; Mertens, Ann C; Packer, Roger J; Robison, Leslie L; Sklar, Charles A

    2003-10-01

    The objectives of this study were 1) to compare final height and body mass index (BMI) between adult survivors of childhood brain cancer and age- and sex-matched population norms, 2) to quantify the effects of treatment- and cancer-related factors on the risk of final height below the 10th percentile (adult short stature) or having a BMI of 30 kg/m(2) or more (obesity). Treatment records were abstracted and surveys completed by 921 adults aged 20-45 yr who were treated for brain cancer as children and were participants in the multicenter Childhood Cancer Survivor Study. Nearly 40% of childhood brain cancer survivors were below the 10th percentile for height. The strongest risk factors for adult short stature were young age at diagnosis and radiation treatment involving the hypothalamic-pituitary axis (HPA). The multivariate odds ratio for adult short stature among those 4 yr of age or younger at diagnosis, relative to ages 10-20 yr, was 5.67 (95% confidence interval, 3.6-8.9). HPA radiation exposure increased the risk of adult short stature in a dose-response fashion (trend test, P obesity. Except for patients treated with surgery only, survivors of childhood brain cancer are at very high risk for adult short stature, and this risk increases with radiation dose involving the HPA. We did not find a corresponding elevated risk for obesity.

  11. Methodology of constructive technology assessment in health care

    NARCIS (Netherlands)

    Douma, Kirsten F.L.; Karsenberg, Kim; Hummel, Marjan J.M.; Bueno-de-Mesquita, Jolien M.; Harten, van Wim H.

    2007-01-01

    Objectives: Technologies in health care are evolving quickly, with new findings in the area of biotechnological and genetic research being published regularly. A health technology assessment (HTA) is often used to answer the question of whether the new technology should be implemented into clinical

  12. New Modes of Constructive Technology Assessment for Developing Countries

    DEFF Research Database (Denmark)

    Christensen, David; Remmen, Arne

    . Technology assessment helps assess the potential positive or negative impacts following in the wake of introducing a new technology of any conceivable type. It has an overall philosophy of reducing the cost of learning in society’s handling of new technologies, anticipating impacts and feeding these insights...... in influencing technological change. In developing countries, technology assessment has received relatively little attention, but recent developments have expressed a ‘call-to-arms’ to tailor flexible approaches by ensuring the involvement of diverse stakeholders and citizens and continual learning among......An old piece of conventional wisdom warns against unsustainable ‘white elephants’ in any attempts at international transferal, adoption or development of technologies in developing countries. After more than half a century of failed attempts to introduce technologies in such settings mostly through...

  13. Scenario drafting to anticipate future developments in technology assessment

    Directory of Open Access Journals (Sweden)

    Retèl Valesca P

    2012-08-01

    Full Text Available Abstract Background Health Technology Assessment (HTA information, and in particular cost-effectiveness data is needed to guide decisions, preferably already in early stages of technological development. However, at that moment there is usually a high degree of uncertainty, because evidence is limited and different development paths are still possible. We developed a multi-parameter framework to assess dynamic aspects of a technology -still in development-, by means of scenario drafting to determine the effects, costs and cost-effectiveness of possible future diffusion patterns. Secondly, we explored the value of this method on the case of the clinical implementation of the 70-gene signature for breast cancer, a gene expression profile for selecting patients who will benefit most from chemotherapy. Methods To incorporate process-uncertainty, ten possible scenarios regarding the introduction of the 70-gene signature were drafted with European experts. Out of 5 most likely scenarios, 3 drivers of diffusion (non-compliance, technical failure, and uptake were quantitatively integrated in a decision-analytical model. For these scenarios, the cost-effectiveness of the 70-gene signature expressed in Incremental Cost-Effectiveness Ratios (ICERs was compared to clinical guidelines, calculated from the past (2005 until the future (2020. Results In 2005 the ICER was €1,9 million/quality-adjusted-life-year (QALY, meaning that the 70-gene signature was not yet cost-effective compared to the current clinical guideline. The ICER for the 70-gene signature improved over time with a range of €1,9 million to €26,145 in 2010 and €1,9 million to €11,123/QALY in 2020 depending on the separate scenario used. From 2010, the 70-gene signature should be cost-effective, based on the combined scenario. The uptake-scenario had strongest influence on the cost-effectiveness. Conclusions When optimal diffusion of a technology is sought, incorporating process

  14. Climate Change Vulnerability Assessments: Four Case Studies of Water Utility Practices (2011 Final)

    Science.gov (United States)

    EPA has released the final report titled, Climate Change Vulnerability Assessments: Four Case Studies of Water Utility Practices. This report was prepared by the National Center for Environmental Assessment's Global Climate Research Staff in the Office of Research and D...

  15. Evaluation of technology transferring: The experiences of the first Navy Domestic Technology Transfair. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1989-12-31

    In August 1989 the Office of the Chief of Naval Research and the American Defense Preparedness Association conducted the first Navy Domestic Technology Transfair. The objective of the Transfair was to expose the US Navy`s years of solid experience across a broad span of technology to organizations outside of the Navy. It was an opportunity for private industry to capitalize on the Navy developed technology and this opening for industry was the primary focus of the Transfair. The event provided a unique forum to meet leading Navy scientific and engineering innovators face-to-face. Information was available concerning licensing of naval technology that was for sale to the private sector. Further, discussions covered opportunities for new cooperative research and development agreements with Navy laboratories and R&D activities. These agreements were authorized under the Federal Technology Transfer Act of 1986. The Transfair program was conducted in such a manner as to allow each Navy inventor, either scientist or engineer, to present a system, piece of hardware, or licensable concept in a formal paper presentation. Then, the Navy inventors were available in two, two-hour periods in which individual discussions were conducted, with attendees pursuing specific venues of cooperative agreements as desired. This report provides specifics concerning the technologies that were made available for transfer to the private sector during the Transfair. The Transfair concept sought to add special emphasis to the opening that the 1988 Technology Transfer Act brought to the marketplace. The experience was a step in the education of the possibilities for cooperation between the government and the private sector to share technology. Of additional significance is the economic enhancement for business expansion with the application of the technology to markets beyond defense.

  16. Sustainability assessment of advanced wastewater treatment technologies

    DEFF Research Database (Denmark)

    Høibye, Linda; Clauson-Kaas, Jes; Wenzel, Henrik

    2008-01-01

    with advanced oxidation. The technical assessment is based on 12 hazardous substances comprising heavy metals, organic pollutants, endocrine disruptors as well as pathogenic microorganisms. The environmental assessment is performed by life cycle assessment (LCA) comprising 9 of the specific hazardous substances...

  17. The Contribution of Health Technology Assessment, Health Needs Assessment, and Health Impact Assessment to the Assessment and Translation of Technologies in the Field of Public Health Genomics

    DEFF Research Database (Denmark)

    Rosenkotter, N.; Vondeling, H.; Blancquaert, I.

    2011-01-01

    or to identify infrastructural needs. HIA delivers information on the impact of technologies in a wider scope and promotes informed decision making. HTA, HNA and HIA provide a partly overlapping and partly unique set of methodologies and infrastructure for the translation and assessment of genomic health...... into the impact on public health and health care practice of those technologies that are actually introduced. This paper aims to give an overview of the major assessment instruments in public health [ health technology assessment (HTA), health needs assessment (HNA) and health impact assessment (HIA)] which could......The European Union has named genomics as one of the promising research fields for the development of new health technologies. Major concerns with regard to these fields are, on the one hand, the rather slow and limited translation of new knowledge and, on the other hand, missing insights...

  18. IES Integrated Learning Assessment Final Report. CRESST Report 788

    Science.gov (United States)

    Silver, David; Hansen, Mark; Herman, Joan; Silk, Yael; Greenleaf, Cynthia L.

    2011-01-01

    The main purpose of this study was to examine the effects of the Reading Apprenticeship professional development program on several teacher and student outcomes, including effects on student learning. A key part of the study was the use of an enhanced performance assessment program, the Integrated Learning Assessment (ILA), to measure student…

  19. Maryland Nutrition Education Needs Assessment, Final Report and Supplements, 1986.

    Science.gov (United States)

    Bunch, Michael B.; Watson, Donna J. R.

    The nutrition education needs of Maryland school children, teachers, and food service personnel (FSP) were assessed during the 1986-87 school year, as a follow-up to a 1979-80 study. Materials developed by the Educational Support Services Branch (ESSB) were reviewed; the Nutrition Assessment Inventory (NAI) was given to 750 students each from…

  20. Multiple Intelligences: Curriculum and Assessment Project. Final Report

    Science.gov (United States)

    Hyland, Aine, Ed.

    2011-01-01

    The "Multiple Intelligences, Curriculum and Assessment Project" at University College Cork was a collaborative project carried out between 1995 and 1999. The key research question focused on whether Howard Gardner's theory of Multiple Intelligences could be applied to, and enhance, aspects of curriculum and assessment at primary and second level…

  1. Establishing a family risk assessment clinic for breast cancer.

    LENUS (Irish Health Repository)

    Mulsow, Jurgen

    2012-02-01

    Breast cancer is the most common cancer affecting European women and the leading cause of cancer-related death. A total of 15-20% of women who develop breast cancer have a family history and 5-10% a true genetic predisposition. The identification and screening of women at increased risk may allow early detection of breast cancer and improve prognosis. We established a family risk assessment clinic in May 2005 to assess and counsel women with a family history of breast cancer, to initiate surveillance, and to offer risk-reducing strategies for selected high-risk patients. Patients at medium or high risk of developing breast cancer according to NICE guidelines were accepted. Family history was determined by structured questionnaire and interview. Lifetime risk of developing breast cancer was calculated using Claus and Tyrer-Cuzick scoring. Risk of carrying a breast cancer-related gene mutation was calculated using the Manchester system. One thousand two hundred and forty-three patients have been referred. Ninety-two percent were at medium or high risk of developing breast cancer. Formal assessment of risk has been performed in 368 patients, 73% have a high lifetime risk of developing breast cancer, and 72% a Manchester score >or=16. BRCA1\\/2 mutations have been identified in 14 patients and breast cancer diagnosed in two. Our initial experience of family risk assessment has shown there to be a significant demand for this service. Identification of patients at increased risk of developing breast cancer allows us to provide individuals with accurate risk profiles, and enables patients to make informed choices regarding their follow-up and management.

  2. Idaho National Laboratory Technology to Market (T2M) Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Wright, Christopher Todd [Idaho National Lab. (INL), Idaho Falls, ID (United States); Bush, Jason William [Idaho National Lab. (INL), Idaho Falls, ID (United States); Gentle, Jake Paul [Idaho National Lab. (INL), Idaho Falls, ID (United States); Hill, Porter Jack [Idaho National Lab. (INL), Idaho Falls, ID (United States); Myers, Kurt Steven [Idaho National Lab. (INL), Idaho Falls, ID (United States); Williams, Christopher Luke [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-01-01

    The objective of this project is to establish a tiered Technology to Market (T2M) curriculum for basic researchers to project leads to measure the effect of technology transfer skills on project success and impact. The plan will train five researchers in basic technology transfer principles where success will be measured by assessing improvements in T2M skills and knowledge after the training is complete, likely using before and after surveys.

  3. Carbon black dispersion pre-plating technology for printed wire board manufacturing. Final technology evaluation report

    Energy Technology Data Exchange (ETDEWEB)

    Folsom, D.W.; Gavaskar, A.R.; Jones, J.A.; Olfenbuttel, R.F.

    1993-10-01

    The project compared chemical use, waste generation, cost, and product quality between electroless copper and carbon-black-based preplating technologies at the printed wire board (PWB) manufacturing facility of McCurdy Circuits in Orange, CA. The carbon-black based preplating technology evaluated is used as an alternative process for electroless copper (EC) plating of through-holes before electrolytic copper plating. The specific process used at McCurdy is the BlackHole (BH) technology process, which uses a dispersion of carbon black in an aqueous solution to provide a conductive surface for subsequent electrolytic copper plating. The carbon-black dispersion technology provided effective waste reduction and long-term cost savings. The economic analysis determined that the new process was cost efficient because chemical use was reduced and the process proved more efficient; the payback period was less than 4 yrs.

  4. Awareness, Interest, and Preferences of Primary Care Providers in Using Point-of-Care Cancer Screening Technology.

    Directory of Open Access Journals (Sweden)

    Chloe S Kim

    Full Text Available Well-developed point-of-care (POC cancer screening tools have the potential to provide better cancer care to patients in both developed and developing countries. However, new medical technology will not be adopted by medical providers unless it addresses a population's existing needs and end-users' preferences. The goals of our study were to assess primary care providers' level of awareness, interest, and preferences in using POC cancer screening technology in their practice and to provide guidelines to biomedical engineers for future POC technology development. A total of 350 primary care providers completed a one-time self-administered online survey, which took approximately 10 minutes to complete. A $50 Amazon gift card was given as an honorarium for the first 100 respondents to encourage participation. The description of POC cancer screening technology was provided in the beginning of the survey to ensure all participants had a basic understanding of what constitutes POC technology. More than half of the participants (57% stated that they heard of the term "POC technology" for the first time when they took the survey. However, almost all of the participants (97% stated they were either "very interested" (68% or "somewhat interested" (29% in using POC cancer screening technology in their practice. Demographic characteristics such as the length of being in the practice of medicine, the percentage of patients on Medicaid, and the average number of patients per day were not shown to be associated with the level of interest in using POC. These data show that there is a great interest in POC cancer screening technology utilization among this population of primary care providers and vast room for future investigations to further understand the interest and preferences in using POC cancer technology in practice. Ensuring that the benefits of new technology outweigh the costs will maximize the likelihood it will be used by medical providers and

  5. Awareness, Interest, and Preferences of Primary Care Providers in Using Point-of-Care Cancer Screening Technology.

    Science.gov (United States)

    Kim, Chloe S; Vanture, Sarah; Cho, Margaret; Klapperich, Catherine M; Wang, Catharine; Huang, Franklin W

    2016-01-01

    Well-developed point-of-care (POC) cancer screening tools have the potential to provide better cancer care to patients in both developed and developing countries. However, new medical technology will not be adopted by medical providers unless it addresses a population's existing needs and end-users' preferences. The goals of our study were to assess primary care providers' level of awareness, interest, and preferences in using POC cancer screening technology in their practice and to provide guidelines to biomedical engineers for future POC technology development. A total of 350 primary care providers completed a one-time self-administered online survey, which took approximately 10 minutes to complete. A $50 Amazon gift card was given as an honorarium for the first 100 respondents to encourage participation. The description of POC cancer screening technology was provided in the beginning of the survey to ensure all participants had a basic understanding of what constitutes POC technology. More than half of the participants (57%) stated that they heard of the term "POC technology" for the first time when they took the survey. However, almost all of the participants (97%) stated they were either "very interested" (68%) or "somewhat interested" (29%) in using POC cancer screening technology in their practice. Demographic characteristics such as the length of being in the practice of medicine, the percentage of patients on Medicaid, and the average number of patients per day were not shown to be associated with the level of interest in using POC. These data show that there is a great interest in POC cancer screening technology utilization among this population of primary care providers and vast room for future investigations to further understand the interest and preferences in using POC cancer technology in practice. Ensuring that the benefits of new technology outweigh the costs will maximize the likelihood it will be used by medical providers and patients.

  6. Evaluation of technology modifications required to apply clean coal technologies in Russian utilities. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-01

    The report describes the following: overview of the Russian power industry; electric power equipment of Russia; power industry development forecast for Russia; clean coal technology demonstration program of the US Department of Energy; reduction of coal TPS (thermal power station) environmental impacts in Russia; and base options of advanced coal thermal power plants. Terms of the application of clean coal technology at Russian TPS are discussed in the Conclusions.

  7. Human Papilloma Viruses and Breast CancerAssessment of Causality

    Science.gov (United States)

    Lawson, James Sutherland; Glenn, Wendy K.; Whitaker, Noel James

    2016-01-01

    High risk human papilloma viruses (HPVs) may have a causal role in some breast cancers. Case–control studies, conducted in many different countries, consistently indicate that HPVs are more frequently present in breast cancers as compared to benign breast and normal breast controls (odds ratio 4.02). The assessment of causality of HPVs in breast cancer is difficult because (i) the HPV viral load is extremely low, (ii) HPV infections are common but HPV associated breast cancers are uncommon, and (iii) HPV infections may precede the development of breast and other cancers by years or even decades. Further, HPV oncogenesis can be indirect. Despite these difficulties, the emergence of new evidence has made the assessment of HPV causality, in breast cancer, a practical proposition. With one exception, the evidence meets all the conventional criteria for a causal role of HPVs in breast cancer. The exception is “specificity.” HPVs are ubiquitous, which is the exact opposite of specificity. An additional reservation is that the prevalence of breast cancer is not increased in immunocompromised patients as is the case with respect to HPV-associated cervical cancer. This indicates that HPVs may have an indirect causal influence in breast cancer. Based on the overall evidence, high-risk HPVs may have a causal role in some breast cancers. PMID:27747193

  8. Social impact assessment: A review and proposed approach: Final report

    Energy Technology Data Exchange (ETDEWEB)

    Bradbury, J A

    1986-12-01

    The objective of the report is to identify the essential components of a comprehensive plan to assess the potential social impacts of the proposed construction and operation of a high level radioactive waste repository by the Nevada Nuclear Waste Storage Investigations (NNWSI) Project. The tasks taken to achieve this objective are: examination of the literature on Social Impact Assessment (SIA); identification of different conceptual frameworks that have been proposed or used in SIA; examination of specific aspects of the frameworks; assessment of strengths and weaknesses of the frameworks; synthesis of common elements in these frameworks; and examination and evaluation of methods of data collection and analysis. 150 refs., 6 figs., 7 tabs.

  9. Health technology assessment and the media: more compatible than one may think?

    Science.gov (United States)

    Hivon, Myriam; Lehoux, Pascale; Rock, Melanie; Denis, Jean-Louis

    2012-05-01

    While the Health Technology Assessment (HTA) community has acknowledged the importance of public and consumer involvement in the HTA process, very few studies have examined how technology-related findings may be reported by the media to the broader public. This paper compares the content of press articles with the content of three Canadian HTA reports that respectively assess electroconvulsive therapy, first-trimester prenatal screening for Down syndrome, and prostate-specific antigen screening for prostate cancer. We qualitatively and quantitatively analyzed 186 press articles addressing the same technologies. Our results show that beyond stylistic emphasis, there is an important overlap between media coverage of these technologies and the content of HTA reports. Findings also highlight shared interests on which both researchers and journalists could build to enhance the communication of health information to the public.

  10. Testicular Cancer and Testicular Self-Examination; Knowledge, Attitudes and Practice in Final Year Medical Students in Nigeria

    Science.gov (United States)

    Ugwumba, Fred O; Ekwueme, Osa Eloka C; Okoh, Agharighom D

    2016-11-01

    The testicular cancer (TCa) incidence is increasing in many countries, with age-standardized incidence rates up to 7.8/100,000 men in the Western world, although reductions in mortality and increasingly high cure rates are being witnessed at the same time. In Africa, where rates are lower, presentation is often late and morbidity and mortality high. Given this scenario, awareness of testicular cancer and practice of testicular self-examination among future first response doctors is very important. This study was conducted to determine knowledge and attitude to testicular cancer, and practice of testicular self-examination (TSE) among final (6th) year medical students. In addition, the effect of an intervention in the form of a single PowerPoint® lecture, lasting 40 minutes with image content on testicular cancer and testicular self examination was assessed. Pre and post intervention administration of a self-administered structured pre tested questionnaire was performed on 151 medical students, 101 of whom returned answers (response rate of 66.8%). In the TC domain, there was a high level of awareness of testicular cancer, but poor knowledge of the age group most affected, with significant improvement post intervention (ptesticular self-examination pre-intervention was found considering the nature of the study group..Respondents had surprisingly weak/poor responses to the question “How important to men’s health is regular testicular self-examination?” Answers to the questions “Do you think it is worthwhile to examine your testis regularly?” and “Would you be interested in more information on testicular cancer and testicular self-examination?” were also suboptimal, but improved post intervention ptesticular cancer in the curricula of medical schools and other training institutions for health care personnel.

  11. Final Addendum to the Necedah National Wildlife Refuge Environmental Assessment

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of this Addendum is to clarify actions that will be taken under the selected alternative for the Fire Management Plan Environmental Assessment that was...

  12. Final Environmental Assessment : Marais des Cygnes National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Environmental Assessment for the acquisition of approximately 9,300 acres known as Marais des Cygnes National Wildlife Refuge for the purpose of protecting...

  13. 77 FR 41774 - Notice of Final Environmental Assessment and Finding of No Significant Impact for the...

    Science.gov (United States)

    2012-07-16

    ... of Final Environmental Assessment and Finding of No Significant Impact for the Construction and... significant impact. SUMMARY: Pursuant to the National Environmental Policy Act of 1969, as amended (NEPA) (42... Final Environmental Assessment (EA) for construction and operation of a radiological work and...

  14. Cancer Fatalism and Preferred Sources of Cancer Information: an Assessment Using 2012 HINTS Data.

    Science.gov (United States)

    Sinky, Tassnym H; Faith, Jennifer; Lindly, Olivia; Thorburn, Sheryl

    2016-09-20

    Cancer fatalism is associated with lower participation in cancer screening, nonadherence to cancer screening guidelines, and avoidance of medical care. Few studies, however, have examined the relationship between cancer fatalism and health information seeking. The purpose of this study was to examine the relationship between endorsement of fatalistic beliefs regarding cancer and preferred sources of cancer information. We analyzed data from the Health Information National Trends Survey 4 Cycle 2, which were collected in late 2012 and early 2013 (N = 3630). When weighted, the data are representative of the non-institutionalized US population aged 18 or older. In bivariate and multivariate analyses, we assessed three cancer fatalism beliefs as predictors of preferred use of healthcare provider versus preferred use of the Internet for cancer information. Results indicate the majority of US adults endorse one or more fatalistic beliefs about cancer. Unadjusted results indicate endorsing the fatalistic belief that "there's not much you can do to lower your chances of getting cancer" was significantly associated with lower odds of preferring the Internet (versus healthcare providers) as the source of cancer information (OR: 0.70; CI: 0.50, 0.98). In the adjusted model, however, none of the three cancer fatalism measures were significantly associated with preferred source of cancer information. In conclusion, fatalistic beliefs about cancer are common, and further research is warranted to understand cancer fatalism and whether and how it may impact health information-seeking behaviors.

  15. Nevada low-temperaure geothermal resource assessment: 1994. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Garside, L.J.

    1994-12-31

    Data compilation for the low-temperature program is being done by State Teams in two western states. Final products of the study include: a geothermal database, in hardcopy and as digital data (diskette) listing information on all known low- and moderate- temperature springs and wells in Nevada; a 1:1,000,000-scale map displaying these geothermal localities, and a bibliography of references on Nevada geothermal resources.

  16. Technology assessments in transportation: survey of recent literature

    Energy Technology Data Exchange (ETDEWEB)

    LaBelle, S.J.

    1980-03-01

    A survey and an evaluation of recent studies of transportation systems done in a technology-assessment framework were undertaken as the basis for a detailed statement of work for a US Department of Energy technology assessment of transportation energy-conservation strategies. Several bibliographies were searched and numerous professionals in the field of technology assessment were contacted regarding current work. Detailed abstracts were prepared for studies judged to be sufficiently broad in coverage of impacts assessed, yet detailed in coverage of all or part of the nation's transportation systems. Some studies were rich in data but not comprehensive in their analytical approach; brief abstracts were prepared for these. An explanation of the criteria used to screen the studies, as well as abstracts of 37 reports, are provided in this compendium of transportation-technology-assessment literature.

  17. 78 FR 14111 - Final Candidate Conservation Agreement With Assurances, Final Environmental Assessment, and...

    Science.gov (United States)

    2013-03-04

    ... development, wind energy development, loss of native rangelands to cropland conversion, herbicide use, fire... on multiple environmental and social factors, including potential impacts to the LEPC, the benefits... Assessment, and Finding of No Significant Impact; Lesser Prairie Chicken, Oklahoma AGENCY: Fish and...

  18. Fostering and Assessing Creativity in Technology Education

    Science.gov (United States)

    Buelin-Biesecker, Jennifer Katherine

    2012-01-01

    This study compared the creative outcomes in student work resulting from two pedagogical approaches to creative problem solving activities. A secondary goal was to validate the Consensual Assessment Technique (CAT) as a means of assessing creativity. Linear models for problem solving and design processes serve as the current paradigm in classroom…

  19. Superconducting Technology Assessment (NSA, Office of Corporate Assessments)

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — The government, and particularly NSA, has a continuing need for ever-increasing computational power. The Agency is concerned about projected limitations of...

  20. 20 Years of Technology and Language Assessment in "Language Learning & Technology"

    Science.gov (United States)

    Chapelle, Carol A.; Voss, Erik

    2016-01-01

    This review article provides an analysis of the research from the last two decades on the theme of technology and second language assessment. Based on an examination of the assessment scholarship published in "Language Learning & Technology" since its launch in 1997, we analyzed the review articles, research articles, book reviews,…

  1. Using technology in assessing integrated science and mathematics learning

    Science.gov (United States)

    Berlin, Donna F.; White, Arthur L.

    1995-03-01

    Drawing from current models, research, and science and mathematics education reform documents, this article first defines and/or delimits three broad domains of education: integrated school science and mathematics, assessment, and technology. Based upon this three-tiered discussion, a list of characteristics is then distilled to guide in the development of assessment for integrated school science and mathematics using technology. Two integrated school science and mathematics activities are provided to illustrate the alignment of instruction and assessment and the systematic integration of technology into both.

  2. General support for integrated assessment research. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Dowlatabadi, Hadi

    2001-03-01

    The climate change problem spans an extraordinarily large number of disciplines from earth sciences to social and political sciences. The interaction of processes described by these different fields is why climate change is such a complex issue. Keeping track of these interactions and bringing coherence to the assumptions underlying each disciplinary insight on the climate problem is a massive undertaking. Integrated assessment is an interdisciplinary approach designed to provide systematic evaluations of technically complex problems such as the analysis of environmental change challenges facing humanity. Ph.D. theses stemming from this application are summarized. Then some aspects of Integrated Climate Assessment Models are described.

  3. Navajo-ABLE: Replication Model Navajo Assistive Technology Loan Program. Final Program Evaluation.

    Science.gov (United States)

    Norton, Katie Jebb

    This final report discusses the activities and outcomes of the Navajo Assistive Bank of Loanable Equipment (Navajo-ABLE), a federally funded program designed to provide assistive technology (AT) devices, services, technical information, funding information, and training for Navajo children and youth with disabilities. The program was operated and…

  4. Methods for assessment of innovative medical technologies during early stages of development.

    Science.gov (United States)

    Bartelmes, Marc; Neumann, Ulrike; Lühmann, Dagmar; Schönermark, Matthias P; Hagen, Anja

    2009-11-05

    Conventional Health Technology Assessment (HTA) is usually conducted at a point in time at which the development of the respective technology may no longer be influenced. By this time developers and/or purchasers may have misinvested resources. Thus the demand for Technology Assessment (TA) which incorporates appropriate methods during early development stages of a technology becomes apparent. Against this health political background, the present report describes methods for a development-accompanying assessment of innovative medical technologies. Furthermore, international research programmes set out to identify or apply such methods will be outlined. A systematic literature search as well as an extensive manual literature search are carried out in order to obtain literature and information. The greatest units of the identified methods consist of assessment concepts, decision support methods, modelling approaches and methods focusing on users and their knowledge. Additionally, several general-purpose concepts have been identified. The identified research programmes INNO-HTA and MATCH (Multidisciplinary-Assessment-of-Technology-Centre-for-Healthcare) are to be seen as pilot projects which so far have not been able to generate final results. MATCH focuses almost entirely on the incorporation of the user-perspective regarding the development of non-pharmaceutical technologies, whereas INNO-HTA is basically concerned with the identification and possible advancement of methods for the early, socially-oriented technology assessment. Most references offer only very vague descriptions of the respective method and the application of greatly differing methods seldom exceeds the character of a pilot implementation. A standardisation much less an institutionalisation of development-accompanying assessment cannot be recognized. It must be noted that there is no singular method with which development-accompanying assessment should be carried out. Instead, a technology and

  5. Methods for assessment of innovative medical technologies during early stages of development

    Directory of Open Access Journals (Sweden)

    Hagen, Anja

    2009-11-01

    Full Text Available Conventional Health Technology Assessment (HTA is usually conducted at a point in time at which the development of the respective technology may no longer be influenced. By this time developers and/or purchasers may have misinvested resources. Thus the demand for Technology Assessment (TA which incorporates appropriate methods during early development stages of a technology becomes apparent. Against this health political background, the present report describes methods for a development-accompanying assessment of innovative medical technologies. Furthermore, international research programmes set out to identify or apply such methods will be outlined. A systematic literature search as well as an extensive manual literature search are carried out in order to obtain literature and information. The greatest units of the identified methods consist of assessment concepts, decision support methods, modelling approaches and methods focusing on users and their knowledge. Additionally, several general-purpose concepts have been identified. The identified research programmes INNO-HTA and MATCH (Multidisciplinary-Assessment-of-Technology-Centre-for-Healthcare are to be seen as pilot projects which so far have not been able to generate final results. MATCH focuses almost entirely on the incorporation of the user-perspective regarding the development of non-pharmaceutical technologies, whereas INNO-HTA is basically concerned with the identification and possible advancement of methods for the early, socially-oriented technology assessment. Most references offer only very vague descriptions of the respective method and the application of greatly differing methods seldom exceeds the character of a pilot implementation. A standardisation much less an institutionalisation of development-accompanying assessment cannot be recognized. It must be noted that there is no singular method with which development-accompanying assessment should be carried out. Instead, a

  6. Biomedical Technology Assessment The 3Q Method

    CERN Document Server

    Weinfurt, Phillip

    2010-01-01

    Evaluating biomedical technology poses a significant challenge in light of the complexity and rate of introduction in today's healthcare delivery system. Successful evaluation requires an integration of clinical medicine, science, finance, and market analysis. Little guidance, however, exists for those who must conduct comprehensive technology evaluations. The 3Q Method meets these present day needs. The 3Q Method is organized around 3 key questions dealing with 1) clinical and scientific basis, 2) financial fit and 3) strategic and expertise fit. Both healthcare providers (e.g., hospitals) an

  7. LNG vehicle technology, economics, and safety assessment

    Science.gov (United States)

    Powars, Charles A.; Moyer, Carl B.; Lowell, Douglas D.

    1994-02-01

    Liquid natural gas (LNG) is an attractive transportation fuel because of its high heating value and energy density (i.e., Btu/lb. and Btu/gal.), clean burning characteristics, relatively low cost ($/Btu), and domestic availability. This research evaluated LNG vehicle and refueling system technology, economics, and safety. Prior and current LNG vehicle projects were studied to identify needed technology improvements. Life-cycle cost analyses considered various LNG vehicle and fuel supply options. Safety records, standards, and analysis methods were reviewed. The LNG market niche is centrally fueled heavy-duty fleet vehicles with high fuel consumption. For these applications, fuel cost savings can amortize equipment capital costs.

  8. Innovative and Alternative Technology Assessment Manual

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-02-01

    This four chapter, six appendix manual presents the procedures and methodology as well as the baseline costs and energy information necessary for the analysis and evaluation of innovative and alternative technology applications submitted for federal grant assistance under the innovative and alternative technology provisions of the Clean Water Act of 1977. The manual clarifies and interprets the intent of Congress and the Environmental Protection Agency in carrying out the mandates of the innovative and alternative provisions of the Clean Water Act of 1977. [DJE 2005

  9. Child Development Center Construction Project Final Environmental Assessment

    Science.gov (United States)

    2005-04-01

    3-9 3.5.1 Noise Sensitive Receptors...Project Page iii Environmental Assessment LIST OF ACRONYMS 96 ABW 96th Airbase Wing 96 ABW/SEU Range Safety 96 AMDS/ SGB Base Bioenvironmental...site is classified as landscaped/urban. Some longleaf pines would be removed as a result of the construction, but no sensitive species would be

  10. Technologies Assessing Limb Bradykinesia in Parkinson’s Disease

    Science.gov (United States)

    Hasan, Hasan; Athauda, Dilan S.; Foltynie, Thomas; Noyce, Alastair J.

    2017-01-01

    Background: The MDS-UPDRS (Movement Disorders Society – Unified Parkinson’s Disease Rating Scale) is the most widely used scale for rating impairment in PD. Subscores measuring bradykinesia have low reliability that can be subject to rater variability. Novel technological tools can be used to overcome such issues. Objective: To systematically explore and describe the available technologies for measuring limb bradykinesia in PD that were published between 2006 and 2016. Methods: A systematic literature search using PubMed (MEDLINE), IEEE Xplore, Web of Science, Scopus and Engineering Village (Compendex and Inspec) databases was performed to identify relevant technologies published until 18 October 2016. Results: 47 technologies assessing bradykinesia in PD were identified, 17 of which offered home and clinic-based assessment whilst 30 provided clinic-based assessment only. Of the eligible studies, 7 were validated in a PD patient population only, whilst 40 were tested in both PD and healthy control groups. 19 of the 47 technologies assessed bradykinesia only, whereas 28 assessed other parkinsonian features as well. 33 technologies have been described in additional PD-related studies, whereas 14 are not known to have been tested beyond the pilot phase. Conclusion: Technology based tools offer advantages including objective motor assessment and home monitoring of symptoms, and can be used to assess response to intervention in clinical trials or routine care. This review provides an up-to-date repository and synthesis of the current literature regarding technology used for assessing limb bradykinesia in PD. The review also discusses the current trends with regards to technology and discusses future directions in development. PMID:28222539

  11. History of the international societies in health technology assessment: International Society for Technology Assessment in Health Care and Health Technology Assessment International.

    Science.gov (United States)

    Banta, David; Jonsson, Egon; Childs, Paul

    2009-07-01

    The International Society for Technology Assessment in Health Care (ISTAHC) was formed in 1985. It grew out of the increasing awareness of the international dimensions of health technology assessment (HTA) and the need for new communication methods at the international level. The main function of ISTAHC was to present an annual conference, which gradually grew in size, and also to generally improve in quality from to year. ISTAHC overextended itself financially early in the first decade of the 2000s and had to cease its existence. A new society, Health Technology Assessment international (HTAi), based on many of the same ideas and people, grew up beginning in the year 2003. The two societies have played a large role in making the field of HTA visible to people around the world and providing a forum for discussion on the methods and role of HTA.

  12. Releasing the full potential of AIKAN - a dry anaerobic digestion biogas technology. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Joernsgaerd, B.; Broegger Kristensen, M.; Wittrup Hansen, M. [Solum Gruppen, Hedehusene (Denmark); Uellendahl, H. [Aalborg Univ. (AAU), Aalborg (Denmark)

    2013-07-15

    This final project report contains a summary of the findings and documentation which have been carried out as a part of the EUDP-supported project ''Documentation and En-ergy Yield Optimisation of AIKAN{sup }- a dry anaerobic digestion biogas technology''. The aim was to improve documentation of the AIKAN{sup }technology, improve performance of the AIKAN{sup }technology and thus remove important barriers for market entry on principal export markets caused by the lack of performance documentation. The final report also contains a description of the subsequent process and technology improvements which have been carried out in order to improve and optimize the production process at the full scale AIKAN{sup }biogas plant, Biovaekst, in Audebo, Denmark. The relevant analyses carried out as part of the different work packages are attached as appendixes to the report. It is the intention that the final report and the attached appendices should function as a work of reference for the employees involved in the day to day running and optimization of the AIKAN{sup }technology. (Author)

  13. Assessment of the usability of a digital learning technology prototype for monitoring intracranial pressure

    Directory of Open Access Journals (Sweden)

    Lilian Regina de Carvalho

    Full Text Available ABSTRACT Objective: to assess the usability of a digital learning technology prototype as a new method for minimally invasive monitoring of intracranial pressure. Method: descriptive study using a quantitative approach on assessing the usability of a prototype based on Nielsen's ten heuristics. Four experts in the area of Human-Computer interaction participated in the study. Results: the evaluation delivered eight violated heuristics and 31 usability problems in the 32 screens of the prototype. Conclusion: the suggestions of the evaluators were critical for developing an intuitive, user-friendly interface and will be included in the final version of the digital learning technology.

  14. Assessment of Wearable Sensor Technologies for Biosurveillance

    Science.gov (United States)

    2014-11-01

    Illinois ....................................................................................................................................... 29 Nokia ...temperature and light detectors to analyze blood oxygen levels Vibrating Smart Tattoos Nokia Magnetic tattoo that vibrates with your cell...Sensor Technologies for Biosurveillance P a g e 3 0 Nokia Vibrating Tattoos Nokia has employed the use of ferromagnetic ink directly into a

  15. Assessment of the controllability of condensible emissions. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Shareef, G.S.; Waddell, J.T.

    1990-10-01

    The report gives results of a study to gain insights into the condensible emissions area from an air toxics perspective, with emphasis on controllability and chemical composition of these emissions. The study: compiled existing data on condensible emissions; determined the chemical composition of condensible emissions, where possible; identified source categories that are major emitters of condensibles; evaluated the effectiveness of various control devices in reducing condensible emissions; and evaluated how the performance of currently available control technologies can be improved to better control condensible emissions. Two data bases were developed: the Condensibles Data Base contains 43 emission source categories; the Specialized Condensibles Data Base focuses on the chemical composition of condensible emissions.

  16. Final Technical Report for University of Michigan Industrial Assessment Center

    Energy Technology Data Exchange (ETDEWEB)

    Atreya, Arvind

    2007-04-17

    The UM Industrial Assessment Center assisted 119 primary metals, automotive parts, metal casting, chemicals, forest products, agricultural, and glass manufacturers in Michigan, Ohio and Indiana to become more productive and profitable by identifying and recommending specific measures to improve energy efficiency, reduce waste and increase productivity. This directly benefits the environment by saving a total of 309,194 MMBtu of energy resulting in reduction of 0.004 metric tons of carbon emissions. The $4,618,740 implemented cost savings generated also saves jobs that are evaporating from the manufacturing industries in the US. Most importantly, the UM Industrial Assessment Center provided extremely valuable energy education to forty one UM graduate and undergraduate students. The practical experience complements their classroom education. This also has a large multiplier effect because the students take the knowledge and training with them.

  17. Grays River Watershed and Biological Assessment, 2006 Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    May, Christopher; Geist, David [Pacific Northwest National Laboratory

    2007-04-01

    The Grays River Watershed and Biological Assessment was funded to address degradation and loss of spawning habitat for chum salmon (Onchorhynchus keta) and fall Chinook salmon (Onchoryhnchus tshawytscha). In 1999, the National Marine Fisheries Service listed lower Columbia River chum salmon as a threatened Evolutionarily Significant Unit (ESU) under the Endangered Species Act of 1973 (ESA). The Grays River watershed is one of two remaining significant chum salmon spawning locations in this ESU. Runs of Grays River chum and Chinook salmon have declined significantly during the past century, largely because of damage to spawning habitat associated with timber harvest and agriculture in the watershed. In addition, approximately 20-25% of the then-remaining chum salmon spawning habitat was lost during a 1999 channel avulsion that destroyed an important artificial spawning channel operated by the Washington Department of Fish and Wildlife (WDFW). Although the lack of stable, high-quality spawning habitat is considered the primary physical limitation on Grays River chum salmon production today, few data are available to guide watershed management and channel restoration activities. The objectives of the Grays River Watershed and Biological Assessment project were to (1) perform a comprehensive watershed and biological analysis, including hydrologic, geomorphic, and ecological assessments; (2) develop a prioritized list of actions that protect and restore critical chum and Chinook salmon spawning habitat in the Grays River based on comprehensive geomorphic, hydrologic, and stream channel assessments; and (3) gain a better understanding of chum and Chinook salmon habitat requirements and survival within the lower Columbia River and the Grays River. The watershed-based approach to river ecosystem restoration relies on a conceptual framework that describes general relationships between natural landscape characteristics, watershed-scale habitat-forming processes, aquatic

  18. Grays River Watershed and Biological Assessment Final Report 2006.

    Energy Technology Data Exchange (ETDEWEB)

    May, Christopher W.; McGrath, Kathleen E.; Geist, David R. [Pacific Northwest National Laboratory; Abbe, Timothy; Barton, Chase [Herrera Environmental Consultants, Inc.

    2008-02-04

    The Grays River Watershed and Biological Assessment was funded to address degradation and loss of spawning habitat for chum salmon (Onchorhynchus keta) and fall Chinook salmon (Onchoryhnchus tshawytscha). In 1999, the National Marine Fisheries Service listed lower Columbia River chum salmon as a threatened Evolutionarily Significant Unit (ESU) under the Endangered Species Act of 1973 (ESA). The Grays River watershed is one of two remaining significant chum salmon spawning locations in this ESU. Runs of Grays River chum and Chinook salmon have declined significantly during the past century, largely because of damage to spawning habitat associated with timber harvest and agriculture in the watershed. In addition, approximately 20-25% of the then-remaining chum salmon spawning habitat was lost during a 1999 channel avulsion that destroyed an important artificial spawning channel operated by the Washington Department of Fish and Wildlife (WDFW). Although the lack of stable, high-quality spawning habitat is considered the primary physical limitation on Grays River chum salmon production today, few data are available to guide watershed management and channel restoration activities. The objectives of the Grays River Watershed and Biological Assessment project were to (1) perform a comprehensive watershed and biological analysis, including hydrologic, geomorphic, and ecological assessments; (2) develop a prioritized list of actions that protect and restore critical chum and Chinook salmon spawning habitat in the Grays River based on comprehensive geomorphic, hydrologic, and stream channel assessments; and (3) gain a better understanding of chum and Chinook salmon habitat requirements and survival within the lower Columbia River and the Grays River. The watershed-based approach to river ecosystem restoration relies on a conceptual framework that describes general relationships between natural landscape characteristics, watershed-scale habitat-forming processes, aquatic

  19. Influence choreographic readiness to gymnasts final assessment of performance skills

    Directory of Open Access Journals (Sweden)

    Omelichyk-Ziurkalova O.A.

    2014-06-01

    Full Text Available Purpose : to provide a quantitative assessment and expert choreographic preparedness gymnasts. Material : the study involved eight gymnasts competition finalists in the floor exercise - female members of the Ukrainian national team in gymnastics. Results : the quantitative indicators of acrobatic and dance elements to determine the baseline assessment. Defined methods complications composition on the floor exercise by reducing the number of acrobatic lines and diagonals and increase the number of gymnastic elements. The theoretical performance of the composite sequence is improved structure and increases the difficulty of the exercise. Conclusions : in the process of composition complications need to pay more attention to the technique of performing gymnastic elements. In improving exercise choreography element replace (in some cases acrobatic element. Based on the results is planned future direction of research in order to improve the training process in gymnastics.

  20. Technical assessment of maglev system concepts. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lever, J.H.

    1998-10-01

    The Government Maglev System Assessment Team operated from 1991 to 1993 as part of the National Maglev Initiative. They assessed the technical viability of four US Maglev system concepts, using the French TGV high speed train and the German TR07 Maglev system as assessment baselines. Maglev in general offers advantages that include high speed potential, excellent system control, high capacity, low energy consumption, low maintenance, modest land requirements, low operating costs, and ability to meet a variety of transportation missions. Further, the US Maglev concepts could provide superior performance to TR07 for similar cost or similar performance for less cost. They also could achieve both lower trip times and lower energy consumption along typical US routes. These advantages result generally from the use of large gap magnetic suspensions, more powerful linear synchronous motors and tilting vehicles. Innovative concepts for motors, guideways, suspension, and superconducting magnets all contribute to a potential for superior long term performance of US Maglev systems compared with TGV and TR07.

  1. Generating technology assessment. Phase I work plan, Task 1 report

    Energy Technology Data Exchange (ETDEWEB)

    1979-10-15

    A plan of work outlining information to assess electric generating technologies is presented. Projections are made of realistic and understandable engineering and cost assessments of nonnuclear electrical generating technologies. A computer-based method of producing such engineering and cost estimates for use by EIA's Coal and Electric Power Analysis Division is to be developed and implemented. Technologies and processes to be assessed are: all nonnuclear conventional and nonconventional (coal gasification, advanced combustion turbines, atmospheric fluidized bed combustion, fuel cells, geothermal, solar thermal and photovoltaics, biomass conversion to electricity, ocean thermal, wind, and MHD). Engineering specifications recommended for determination are listed. Compatibility of the technologies are to be assessed with EIA models: MEFS, LEAP, and NCM.

  2. Systems Engineering Technology Readiness Assessment of Hybrid-Electric Technologies for Tactical Wheeled Vehicles

    Science.gov (United States)

    2014-09-01

    Department of Energy. 2007. Energy Efficiency and Renewable Energy. “Freedom CAR and vehicle technology program; Plug-In hybrid- electric vehicle R&D Plan...ENGINEERING TECHNOLOGY READINESS ASSESSMENT OF HYBRID- ELECTRIC TECHNOLOGIES FOR TACTICAL WHEELED VEHICLES by Eddie E. McCown September 2014 Thesis...HYBRID- ELECTRIC TECHNOLOGIES FOR TACTICAL WHEELED VEHICLES 5. FUNDING NUMBERS 6. AUTHOR(S) Eddie E. McCown 7. PERFORMING ORGANIZATION NAME(S) AND

  3. Advanced Turbine Technology Applications Project (ATTAP) and Hybrid Vehicle Turbine Engine Technology Support project (HVTE-TS): Final summary report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-01

    This final technical report was prepared by Rolls-Royce Allison summarizing the multiyear activities of the Advanced Turbine Technology Applications Project (ATTAP) and the Hybrid Vehicle Turbine Engine Technology Support (HVTE-TS) project. The ATTAP program was initiated in October 1987 and continued through 1993 under sponsorship of the US Department of Energy (DOE), Energy Conservation and Renewable Energy, Office of Transportation Technologies, Propulsion Systems, Advanced Propulsion Division. ATTAP was intended to advance the technological readiness of the automotive ceramic gas turbine engine. The target application was the prime power unit coupled to conventional transmissions and powertrains. During the early 1990s, hybrid electric powered automotive propulsion systems became the focus of development and demonstration efforts by the US auto industry and the Department of energy. Thus in 1994, the original ATTAP technology focus was redirected to meet the needs of advanced gas turbine electric generator sets. As a result, the program was restructured to provide the required hybrid vehicle turbine engine technology support and the project renamed HVTE-TS. The overall objective of the combined ATTAP and HVTE-TS projects was to develop and demonstrate structural ceramic components that have the potential for competitive automotive engine life cycle cost and for operating 3,500 hr in an advanced high temperature turbine engine environment. This report describes materials characterization and ceramic component development, ceramic components, hot gasifier rig testing, test-bed engine testing, combustion development, insulation development, and regenerator system development. 130 figs., 12 tabs.

  4. The readability of online breast cancer risk assessment tools.

    Science.gov (United States)

    Cortez, Sarah; Milbrandt, Melissa; Kaphingst, Kimberly; James, Aimee; Colditz, Graham

    2015-11-01

    Numerous breast cancer risk assessment tools that allow users to input personal risk information and obtain a personalized breast cancer risk estimate are available on the Internet. The goal of these tools is to increase screening awareness and identify modifiable health behaviors; however, the utility of this risk information is limited by the readability of the material. We undertook this study to assess the overall readability of breast cancer risk assessment tools and accompanying information, as well as to identify areas of suggested improvement. We searched for breast cancer risk assessment tools, using five search terms, on three search engines. All searches were performed on June 12, 2014. Sites that met inclusion criteria were then assessed for readability using the suitability assessment of materials (SAM) and the SMOG readability formula (July 1, 2014–January 31, 2015). The primary outcomes are the frequency distribution of overall SAM readability category (superior, adequate, or not suitable) and mean SMOG reading grade level. The search returned 42 sites were eligible for assessment, only 9 (21.4 %) of which achieved an overall SAM superior rating, and 27 (64.3 %) were deemed adequate. The average SMOG reading grade level was grade 12.1 (SD 1.6, range 9–15). The readability of breast cancer risk assessment tools and the sites that host them is an important barrier to risk communication. This study demonstrates that most breast cancer risk assessment tools are not accessible to individuals with limited health literacy skills. More importantly, this study identifies potential areas of improvement and has the potential to heighten a physician’s awareness of the Internet resources a patient might navigate in their quest for breast cancer risk information.

  5. Grays River Watershed and Biological Assessment, 2006 Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    May, Christopher; Geist, David [Pacific Northwest National Laboratory

    2007-04-01

    The Grays River Watershed and Biological Assessment was funded to address degradation and loss of spawning habitat for chum salmon (Onchorhynchus keta) and fall Chinook salmon (Onchoryhnchus tshawytscha). In 1999, the National Marine Fisheries Service listed lower Columbia River chum salmon as a threatened Evolutionarily Significant Unit (ESU) under the Endangered Species Act of 1973 (ESA). The Grays River watershed is one of two remaining significant chum salmon spawning locations in this ESU. Runs of Grays River chum and Chinook salmon have declined significantly during the past century, largely because of damage to spawning habitat associated with timber harvest and agriculture in the watershed. In addition, approximately 20-25% of the then-remaining chum salmon spawning habitat was lost during a 1999 channel avulsion that destroyed an important artificial spawning channel operated by the Washington Department of Fish and Wildlife (WDFW). Although the lack of stable, high-quality spawning habitat is considered the primary physical limitation on Grays River chum salmon production today, few data are available to guide watershed management and channel restoration activities. The objectives of the Grays River Watershed and Biological Assessment project were to (1) perform a comprehensive watershed and biological analysis, including hydrologic, geomorphic, and ecological assessments; (2) develop a prioritized list of actions that protect and restore critical chum and Chinook salmon spawning habitat in the Grays River based on comprehensive geomorphic, hydrologic, and stream channel assessments; and (3) gain a better understanding of chum and Chinook salmon habitat requirements and survival within the lower Columbia River and the Grays River. The watershed-based approach to river ecosystem restoration relies on a conceptual framework that describes general relationships between natural landscape characteristics, watershed-scale habitat-forming processes, aquatic

  6. Grays River Watershed and Biological Assessment Final Report 2006.

    Energy Technology Data Exchange (ETDEWEB)

    May, Christopher W.; McGrath, Kathleen E.; Geist, David R. [Pacific Northwest National Laboratory; Abbe, Timothy; Barton, Chase [Herrera Environmental Consultants, Inc.

    2008-02-04

    The Grays River Watershed and Biological Assessment was funded to address degradation and loss of spawning habitat for chum salmon (Onchorhynchus keta) and fall Chinook salmon (Onchoryhnchus tshawytscha). In 1999, the National Marine Fisheries Service listed lower Columbia River chum salmon as a threatened Evolutionarily Significant Unit (ESU) under the Endangered Species Act of 1973 (ESA). The Grays River watershed is one of two remaining significant chum salmon spawning locations in this ESU. Runs of Grays River chum and Chinook salmon have declined significantly during the past century, largely because of damage to spawning habitat associated with timber harvest and agriculture in the watershed. In addition, approximately 20-25% of the then-remaining chum salmon spawning habitat was lost during a 1999 channel avulsion that destroyed an important artificial spawning channel operated by the Washington Department of Fish and Wildlife (WDFW). Although the lack of stable, high-quality spawning habitat is considered the primary physical limitation on Grays River chum salmon production today, few data are available to guide watershed management and channel restoration activities. The objectives of the Grays River Watershed and Biological Assessment project were to (1) perform a comprehensive watershed and biological analysis, including hydrologic, geomorphic, and ecological assessments; (2) develop a prioritized list of actions that protect and restore critical chum and Chinook salmon spawning habitat in the Grays River based on comprehensive geomorphic, hydrologic, and stream channel assessments; and (3) gain a better understanding of chum and Chinook salmon habitat requirements and survival within the lower Columbia River and the Grays River. The watershed-based approach to river ecosystem restoration relies on a conceptual framework that describes general relationships between natural landscape characteristics, watershed-scale habitat-forming processes, aquatic

  7. Portable optical fiber probe-based spectroscopic scanner for rapid cancer diagnosis: a new tool for intraoperative margin assessment.

    Directory of Open Access Journals (Sweden)

    Niyom Lue

    Full Text Available There continues to be a significant clinical need for rapid and reliable intraoperative margin assessment during cancer surgery. Here we describe a portable, quantitative, optical fiber probe-based, spectroscopic tissue scanner designed for intraoperative diagnostic imaging of surgical margins, which we tested in a proof of concept study in human tissue for breast cancer diagnosis. The tissue scanner combines both diffuse reflectance spectroscopy (DRS and intrinsic fluorescence spectroscopy (IFS, and has hyperspectral imaging capability, acquiring full DRS and IFS spectra for each scanned image pixel. Modeling of the DRS and IFS spectra yields quantitative parameters that reflect the metabolic, biochemical and morphological state of tissue, which are translated into disease diagnosis. The tissue scanner has high spatial resolution (0.25 mm over a wide field of view (10 cm × 10 cm, and both high spectral resolution (2 nm and high spectral contrast, readily distinguishing tissues with widely varying optical properties (bone, skeletal muscle, fat and connective tissue. Tissue-simulating phantom experiments confirm that the tissue scanner can quantitatively measure spectral parameters, such as hemoglobin concentration, in a physiologically relevant range with a high degree of accuracy (<5% error. Finally, studies using human breast tissues showed that the tissue scanner can detect small foci of breast cancer in a background of normal breast tissue. This tissue scanner is simpler in design, images a larger field of view at higher resolution and provides a more physically meaningful tissue diagnosis than other spectroscopic imaging systems currently reported in literatures. We believe this spectroscopic tissue scanner can provide real-time, comprehensive diagnostic imaging of surgical margins in excised tissues, overcoming the sampling limitation in current histopathology margin assessment. As such it is a significant step in the development of a

  8. The conceptual and practical challenges to technology categorisation in the preparation of technology needs assessments

    DEFF Research Database (Denmark)

    Nygaard, Ivan; Hansen, Ulrich Elmer

    2015-01-01

    The strong focus in climate negotiations on the transfer and diffusion of technologies as ameans to mitigate and adapt to climate change has entailed various programs to promote the transfer and diffusion of climate technologies, including the Technology Needs Assessment project (TNA). Despite...... a framework for categorizing technologies according to the types of markets and non-markets in which they are diffused. While the framework has contributed to a higher degree of ‘market literacy’ among national stakeholders, four challenges in categorizing technologies have been identified: i) technologies...

  9. IMPROVING HOSPITAL LOGISTICS BY RETHINKING TECHNOLOGY ASSESSMENT

    DEFF Research Database (Denmark)

    Jacobsen, Peter; Jørgensen, Pelle Morten Thomas

    2011-01-01

    In order to cope with the future challenges of the health care sector, there is an urging need for improving efficiency at hospitals. The study presents a framework enabling health care managers of improving the in-house logistics. The distinctiveness of the framework is the way in which it relates...... technology, logistics, structure and procedures to efficiency. Changing one factor e.g. technology, initiates an iterative loop focusing on change in the related factors in order to obtain the optimal efficiency. The search for an optimal efficient solution is the driving force of the framework...... at a Danish hospital. The framework is tested on the blood sample logistics between the emergency department and laboratory with the goal of enhancing the efficiency of the emergency department....

  10. New Technologies for Standoff Assessment of Radiological Contamination

    Energy Technology Data Exchange (ETDEWEB)

    Cherepy, N; Stevens, C; Wurtz, R; Sanner, R; Frank, M; Tillotson, T; Hrubesh, L; Dietrich, D; Dignon, J; Soufli, R

    2005-05-06

    Technologies to rapidly quantify surface activity with minimal worker contact would dramatically decrease the radiation dose a radiation worker receives in assessment and cleanup operations, while obtaining a clear image of exactly where dispersed contamination is located. LLNL efforts in the development of the Photochromic Radiation Dosimeter and the Imaging Assessment System will be described. Initial use of these technologies in decontamination and decommissioning of contaminated facilities demonstrates several significant advantages over standard techniques such as survey meters and swipes.

  11. Potential Technologies for Assessing Risk Associated with a Mesoscale Forecast

    Science.gov (United States)

    2015-10-01

    the actual model-forecast error—the 500-hPa root-mean-square error (RMSE) height error. Future work should also consider other forecast metrics such...ARL-TN-0708 ● OCT 2015 US Army Research Laboratory Potential Technologies for Assessing Risk Associated with a Mesoscale...OCT 2015 US Army Research Laboratory Potential Technologies for Assessing Risk Associated with a Mesoscale Forecast by Patrick A

  12. Fossil energy biotechnology: A research needs assessment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1993-11-01

    The Office of Program Analysis of the US Department of Energy commissioned this study to evaluate and prioritize research needs in fossil energy biotechnology. The objectives were to identify research initiatives in biotechnology that offer timely and strategic options for the more efficient and effective uses of the Nation`s fossil resource base, particularly the early identification of new and novel applications of biotechnology for the use or conversion of domestic fossil fuels. Fossil energy biotechnology consists of a number of diverse and distinct technologies, all related by the common denominator -- biocatalysis. The expert panel organized 14 technical subjects into three interrelated biotechnology programs: (1) upgrading the fuel value of fossil fuels; (2) bioconversion of fossil feedstocks and refined products to added value chemicals; and, (3) the development of environmental management strategies to minimize and mitigate the release of toxic and hazardous petrochemical wastes.

  13. Understanding differences in the diffusion of environmentally beneficial technology. Final project report

    Energy Technology Data Exchange (ETDEWEB)

    Blackman, A.; Boyd, J.; Simpson, R.D.; Toman, M.

    1996-12-31

    The factors affecting the diffusion of technical discoveries among firms and nations remain one of the most interesting and important but least understood elements of economic behavior. Recently, interest in technology diffusion has been heightened by a recognition that the spread of technologies could have important implications for environmental quality as well as for market goods and services. A specific motivation for this study was the question of how rapidly technologies that reduce greenhouse gas emissions might diffuse. Technologies in this category include technologies that improve the efficiency of fossil energy use or promote substitution of renewable energy resources. The speed with which these technologies spread could have a significant effect on the rate of accumulation of carbon in the atmosphere. From a modeling perspective, the rate of innovation and diffusion of carbon-reducing technology is known to be a crucial parameter in integrated assessments of climate change risks and policy responses. Thus, a better understanding of factors that might influence the spread of carbon-reducing technologies could be valuable in studies on long-term global change and policy assessment.

  14. Defining the "proven technology" technical criterion in the reactor technology assessment for Malaysia's nuclear power program

    Science.gov (United States)

    Anuar, Nuraslinda; Kahar, Wan Shakirah Wan Abdul; Manan, Jamal Abdul Nasir Abd

    2015-04-01

    Developing countries that are considering the deployment of nuclear power plants (NPPs) in the near future need to perform reactor technology assessment (RTA) in order to select the most suitable reactor design. The International Atomic Energy Agency (IAEA) reported in the Common User Considerations (CUC) document that "proven technology" is one of the most important technical criteria for newcomer countries in performing the RTA. The qualitative description of five desired features for "proven technology" is relatively broad and only provides a general guideline to its characterization. This paper proposes a methodology to define the "proven technology" term according to a specific country's requirements using a three-stage evaluation process. The first evaluation stage screens the available technologies in the market against a predefined minimum Technology Readiness Level (TRL) derived as a condition based on national needs and policy objectives. The result is a list of technology options, which are then assessed in the second evaluation stage against quantitative definitions of CUC desired features for proven technology. The potential technology candidates produced from this evaluation is further narrowed down to obtain a list of proven technology candidates by assessing them against selected risk criteria and the established maximum allowable total score using a scoring matrix. The outcome of this methodology is the proven technology candidates selected using an accurate definition of "proven technology" that fulfills the policy objectives, national needs and risk, and country-specific CUC desired features of the country that performs this assessment. A simplified assessment for Malaysia is carried out to demonstrate and suggest the use of the proposed methodology. In this exercise, ABWR, AP1000, APR1400 and EPR designs assumed the top-ranks of proven technology candidates according to Malaysia's definition of "proven technology".

  15. Lifecycle Assessment of Biofuel Production from Wood Pyrolysis Technology

    Science.gov (United States)

    Manyele, S. V.

    2007-01-01

    Due to a stronger dependency on biomass for energy, there is a need for improved technologies in biomass-to-energy conversion in Tanzania. This paper presents a life cycle assessment (LCA) of pyrolysis technology used for conversion of wood and wood waste to liquid biofuel. In particular, a survey of environmental impacts of the process is…

  16. Scenario drafting to anticipate future developments in technology assessment

    NARCIS (Netherlands)

    Retel, V.P.; Joore, M.A.; Rutgers, E.J.; Harten, van W.H.

    2012-01-01

    Background Health Technology Assessment (HTA) information, and in particular cost-effectiveness data is needed to guide decisions, preferably already in early stages of technological development. However, at that moment there is usually a high degree of uncertainty, because evidence is limited and d

  17. Teacher Learning of Technology-Enhanced Formative Assessment

    Science.gov (United States)

    Beatty, Ian D.; Feldman, Allan; Leonard, William J.; Gerace, William J.; St. Cyr, Karen; Lee, Hyunju; Harris, Robby

    2008-01-01

    "Technology-Enhanced Formative Assessment" (TEFA) is an innovative pedagogy for teaching secondary school science or mathematics with "classroom response system" technology. "Teacher Learning of TEFA" (TLT) is a five year research project studying teacher change in the context of an intensive, sustained, on-site professional development (PD)…

  18. CAISI Operational Assessment (OA) data collection results. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-01-31

    One of the lessons learned from Operation Desert Shield/Storm was the inability of deployed Combat Service Support (CSS) computers to exchange data effectively in a battlefield environment. The work-around solution to this previously identified problem has been to physically carry floppy disks between computers. A General Officer Steering Committee, directed by the Vice Chief of Staff of the Army, determined that immediate corrective action was necessary to ensure viability of the CSS Battlefield Mission Area. The study recommended that a three-phased system development plan address short-, mid- and long-term CSS automation communication interface requirements. In response to this study, Program Executive Office (PEO) Standard Army Management Information System (STAMIS) authorized the development of the CSS Automated Information System Interface (CAISI). Phase I (Near-Term) equipped the {open_quotes}first to fight{close_quotes} Contingency Corps units. Phase II (Mid-Term) is being fielded to the remainder of Force Package One units in the active force. Phase III (Long-Term) will equip the remaining units. CAISI is now in the early stages of Phase II fielding. Prior to full Phase II fielding, CAISI must be approved for production by a Milestone III decision authority. Part of the data that will be used in the Milestone III decision is a demonstration of the CAISI`s operational suitability, as assessed by the US Army Operational Test and Evaluation Command (OPTEC). This assessment will be performed through an Operational Assessment (OA) using data provided from previous technical testing, such as the CAISI Customer User Test (CUT), and a field training exercise conducted by units of the XVIII Airborne Corps. The field training exercise data collection took place during two events.

  19. Summative Self-Assessment in Higher Education: Implications of Its Counting towards the Final Mark

    Science.gov (United States)

    Tejeiro, Ricardo A.; Gomez-Vallecillo, Jorge L.; Romero, Antonio F.; Pelegrina, Manuel; Wallace, Agustin; Emberley, Enrique

    2012-01-01

    Introduction: Our study aims at assessing the validity of summative criteria-referenced self-assessment in higher education, and in particular, if that validity varies when the professor counts self-assessment toward the final mark. Method: One hundred and twenty-two first year students from two groups in Teacher Education at the Universidad de…

  20. Technology assessment for Spaceship Two, space tourism, and private spaceflight

    Science.gov (United States)

    Hancock, Randy

    A seven-step technology assessment was conducted to address questions regarding the significance and likely consequences associated with the introduction of Spaceship Two, space tourism, and private spaceflight. Impacts were assessed across four categories: the Role and Functions of Government, Private Industry Factors, Cultural and Societal Impacts, and the Time Frame in which these impacts were anticipated to occur. The technology assessment findings were compared to the results of expert interviews that addressed the sane four categories. The researcher noted that, while there was overwhelming agreement between the technology assessment's primary impacts and the expert interview responses, there were several differences. The technology assessment and interviewees agreed that the federal government would likely be both a regulator and user of private spaceflight. Both agreed that business partnerships would be key in pursuing private spaceflight. There was also consensus that, as market forces come to bear, ticket prices would drop and a larger market and broader passenger demographic would emerge. The technology assessment and experts agreed that an accident, especially one early in the industry's evolution, could be disastrous. Both agreed that private spaceflight can serve as a inspiration to students and be a positive influence in society, and both agreed that the start of passenger flights should take place in the 2010 - 2012 timeframe. Due to the potentially disastrous consequences of an accident, there was agreement between the technology assessment and experts on the value of flight and ground crew training, driven by insurance carriers and federal mandate. Most differences between the technology assessment's findings and the expert interview responses were due to omission, rather than direct disagreement. However, this was not the case in every instance. The most significant difference between the technology assessment and the experts involved the

  1. Final Technical Report: Renewable Energy Feasibility Study and Resources Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Rivero, Mariah [BEC Environmental, Inc., Las Vegas, NV (United States)

    2016-02-28

    In March 2011, the U.S. Department of Energy (DOE) awarded White Pine County, Nevada, a grant to assess the feasibility of renewable resource-related economic development activities in the area. The grant project included a public outreach and training component and was to include a demonstration project; however, the demonstration project was not completed due to lack of identification of an entity willing to locate a project in White Pine County. White Pine County completed the assessment of renewable resources and a feasibility study on the potential for a renewable energy-focused economic sector within the County. The feasibility study concluded "all resources studied were present and in sufficient quantity and quality to warrant consideration for development" and there were varying degrees of potential economic impact based on the resource type and project size. The feasibility study and its components were to be used as tools to attract potential developers and other business ventures to the local market. White Pine County also marketed the County’s resources to the renewable energy business community in an effort to develop contracts for demonstration projects. The County also worked to develop partnerships with local educational institutions, including the White Pine County School District, conducted outreach and training for the local community.

  2. Comparative assessment of marine biomass materials. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Show, I.T. Jr.; Piper, L.E.; Lupton, S.E.; Stegen, G.R.

    1979-09-01

    The objectives of this study were to assess potential marine biomass sources and their preprocessing requirements. For the assessment of marine biomass sources, a priority list of marine plants was developed based on maximum potential organic yields, maximum potential calorific yields, and chemical composition. Yields were maximized and undesirable chemical properties minimized. The priority list was used to estimate maximum potential yields from US coastal water (from shore to the 200-mile limit of the Fisheries Conservation Zone). Preprocessing schemes were compared based on a comparative evaluation of energy consumption for each preprocessing step. The priority list of potential biomass sources produced 13 potential genera; five showed calorific yields far in excess of the other eight. These five (Laminaria, Chondrus, Fucus, Gracilaria, and Macrocystis) had calorific yields in excess of 50 x 10/sup 3/ kcal/m/sup 2/ - yr. No genus was found to be universally applicable to all US territorial waters. It was estimated that maximum potential national yield without mechanical nutrient upwelling could be as high as 30 x 10/sup 5/ Btu/yr (30 quad). Results of the preprocessing study indicated that harvesting and size reduction operations may consume a large proportion of the energy available from the harvested biomass. It was found that biochemical conversion preprocessing incurs the least energy loss. It was also found that thermochemical conversion is probably not appropriate for marine biomass due to preprocessing energy losses.

  3. Low-temperature resource assessment program. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lienau, P.J. [Oregon Inst. of Tech., Klamath Falls, OR (United States). Geo-Heat Center; Ross, H. [Utah Univ., Salt Lake City, UT (United States). Earth Sciences and Resources Inst.

    1996-02-01

    The US Department of Energy - Geothermal Division (DOE/GD) recently sponsored the Low-Temperature Resource Assessment project to update the inventory of the nation`s low- and moderate-temperature geothermal resources and to encourage development of these resources. A database of 8,977 thermal wells and springs that are in the temperature range of 20{degrees}C to 150{degrees}C has been compiled for ten western states, an impressive increase of 82% compared to the previous assessments. The database includes location, descriptive data, physical parameters, water chemistry and references for sources of data. Computer-generated maps are also available for each state. State Teams have identified 48 high-priority areas for near-term comprehensive resource studies and development. Resources with temperatures greater than 50{degrees}C located within 8 km of a population center were identified for 271 collocated cities. Geothermal energy cost evaluation software has been developed to quickly identify the cost of geothermally supplied heat to these areas in a fashion similar to that used for conventionally fueled heat sources.

  4. Final Environmental assessment for the Uranium Lease Management Program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-01

    The US Department of Energy (DOE) has prepared a programmatic environmental assessment (EA) of the proposed action to continue leasing withdrawn lands and DOE-owned patented claims for the exploration and production of uranium and vanadium ores. The Domestic Uranium Program regulation, codified at Title 10, Part 760.1, of the US Code of Federal Regulations (CFR), gives DOE the flexibility to continue leasing these lands under the Uranium Lease Management Program (ULMP) if the agency determines that it is in its best interest to do so. A key element in determining what is in DOE`s ``best interest`` is the assessment of the environmental impacts that may be attributable to lease tract operations and associated activities. On the basis of the information and analyses presented in the EA for the ULMP, DOE has determined that the proposed action does not constitute a major Federal action significantly affecting the quality of the human environment, as defined in the National Environmental Policy Act (NEPA) of 1969 (42 United States Code 4321 et seq.), as amended.Therefore, preparation of an environmental impact statement is not required for the ULMP,and DOE is issuing this Finding, of No Significant Impact (FONSI).

  5. Final Report Low-temperature Resource Assessment Program

    Energy Technology Data Exchange (ETDEWEB)

    Lienau, P.J. [Geo-Heat Center, Oregon Institute of Technology, Klamath Falls, OR (US); Ross, H. [Earth Sciences and Resources Institute, University of Utah

    1996-02-01

    The U.S. Department of Energy - Geothermal Division (DOE/GD) recently sponsored the Low-Temperature Resource Assessment project to update the inventory of the nation's low- and moderate-temperature geothermal resources and to encourage development of these resources. A database of 8,977 thermal wells and springs that are in the temperature range of 20 degrees Celsius to 150 degrees Celsius has been compiled for ten western states, an impressive increase of 82% compared to the previous assessments. The database includes location, descriptive data, physical parameters, water chemistry and references for sources of data. Computer-generated maps are also available for each state. State Teams have identified 48 high-priority areas for near-term comprehensive resource studies and development. Resources with temperatures greater than 50 degrees Celsius located within 8 km of a population center were identified for 271 collocated cities. Geothermal energy costevaluation software has been developed to quickly identify the cost of geothermally supplied heat to these areas in a fashion similar to that used for conventionally fueled heat sources.

  6. Gender and risk assessment in contraceptive technologies

    NARCIS (Netherlands)

    Kammen, van Jessika; Oudshoorn, Nelly

    2002-01-01

    This paper concerns a comparison of risk assessment practices of contraceptives for women and men. Our analysis shows how the evaluation of health risks of contraceptives does not simply reflect the specific effects of chemical compounds in the human body. Rather, we show how side-effects were rated

  7. [Nutritional assessment and perioperative nutritional support in gastric cancer patients].

    Science.gov (United States)

    Seo, Kyung Won; Yoon, Ki Young

    2013-04-01

    Weight loss and malnutrition are common in cancer patients. Although weight loss is predominantly due to loss of fat mass, the morbidity risk is given by the decrease in muscle mass. The assessment of nutritional status is essential for a diagnosis of nutritional compromise and required for the multidisciplinary approach. Subjective global assessment (SGA) is made by the patients nutritional symptoms and weight loss. The objective assessment, a significant weight loss (>10%) for 6 months is considered an indicator of nutritional deficiency. The mean body index, body fat mass and body protein mass are decreased as cancer stage increases. The biochemical data of albumin, cholesterol, triglyceride, Zn, transferrin, total lymphocyte count are decreased in advanced cancer stage. Daily energy intake, cabohyderate and Vit B1 intake is decreased according to cancer stage. The patients are divided into three groups according to SGA. The three groups showed a significant difference in body weight, 1 month weight loss%, 6 month weight loss%, body mass index, mid arm circumference, albumin, energy intake, as well as carbohyderate intake protein and energy malnutrition. Nutritional assessment is of great importance because undernutrition has been shown to be associated with increase in stomach cancer associated morbidity and mortality. The authors concluded that nutritional assessment should be done in cancer patients preoperatively, and with adequate nutritional support, the morbidity and mortality would be decreased.

  8. Quadrennial Technology Review 2015: Technology Assessments--Wind Power

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2015-10-07

    Wind power has become a mainstream power source in the U.S. electricity portfolio, supplying 4.9% of the nation’s electricity demand in 2014. With more than 65 GW installed across 39 states at the end of 2014, utility-scale wind power is a cost-effective source of low-emissions power generation throughout much of the nation. The United States has significant sustainable land-based and offshore wind resource potential, greater than 10 times current total U.S. electricity consumption. A technical wind resource assessment conducted by the Department of Energy (DOE) in 2009 estimated that the land-based wind energy potential for the contiguous United States is equivalent to 10,500 GW capacity at 80 meters (m) hub and 12,000 GW capacity at 100 meters (m) hub heights, assuming a capacity factor of at least 30%. A subsequent 2010 DOE report estimated the technical offshore wind energy potential to be 4,150 GW. The estimate was calculated from the total offshore area within 50 nautical miles of shore in areas where average annual wind speeds are at least 7 m per second at a hub height of 90 m.

  9. [Health research and health technology assessment in Chile].

    Science.gov (United States)

    Espinoza, Manuel Antonio; Cabieses, Báltica; Paraje, Guillermo

    2014-01-01

    Health research is considered an essential element for the improvement of population health and it has been recommended that a share of the national health budget should be allocated to develop this field. Chile has undertaken efforts in the last decades in order to improve the governmental structure created to promote the development of health research, which has increased human resources and funding opportunities. On the other hand, the sustained economic growth of Chile in the last decades suggests that the health expenditure will maintain its increasing trend in the following years. This additional funding could be used to improve coverage of current activities performed in the health system, but also to address the incorporation of new strategies. More recently, health technology assessment (HTA) has been proposed as a process to support decisions about allocation of resources based on scientific evidence. This paper examines the relationship between the development of health research and the HTA process. First, it presents a brief diagnosis of the situation of health research in Chile. Second, it reviews the conceptual basis and the methods that account for the relationship between a HTA process and the development of health research. In particular, it emphasizes the relevance of identifying information gaps where funding additional research can be considered a good use of public resources. Finally, it discusses the challenges and possible courses of action that Chile could take in order to guarantee the continuous improvement of an articulated structure for health research and HTA.

  10. Technology assessment of geothermal energy resource development

    Energy Technology Data Exchange (ETDEWEB)

    1975-04-15

    Geothermal state-of-the-art is described including geothermal resources, technology, and institutional, legal, and environmental considerations. The way geothermal energy may evolve in the United States is described; a series of plausible scenarios and the factors and policies which control the rate of growth of the resource are presented. The potential primary and higher order impacts of geothermal energy are explored, including effects on the economy and society, cities and dwellings, environmental, and on institutions affected by it. Numerical and methodological detail is included in appendices. (MHR)

  11. Fossil energy biotechnology: A research needs assessment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Finnerty, W.R. [Consultec Scientific, Inc., Knoxville, TN (United States)

    1992-04-01

    The Office of Program Analysis of the US Department of Energy commissioned this study to evaluate and prioritize research needs in fossil energy biotechnology. The objectives were to identify research initiatives in biotechnology that offer timely and strategic options for the more efficient and effective uses of the Nation`s fossil resource base, particularly the early identification of new and novel applications of biotechnology for the use or conversion of domestic fossil fuels. Fossil energy biotechnology consists of a number of diverse and distinct technologies, all related by the common denominator -- biocatalysis. The expert panel organized 14 technical subjects into three interrelated biotechnology programs: (1) upgrading the fuel value of fossil fuels; (2) bioconversion of fossil feedstocks and refined products to added value chemicals; and, (3) the development of environmental management strategies to minimize and mitigate the release of toxic and hazardous petrochemical wastes. The integration of these programs as viable bioprocessing initiatives proposes an innovative and conceptual principle for the development of a ``new`` approach to fossil energy biotechnology. This unifying principle is NON-AQUEOUS BIOCATALYSIS. Biocatalysis coupled to conventional chemical catalysis in organic-based media offers bioprocessing options uniquely characterized by the selectivity of biocatalysts plus fast reaction rates and specificity of chemical catalysts.

  12. CleanFleet. Final report: Volume 5, employee attitude assessment

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-01

    The experiences of couriers, operations managers, vehicle handlers (refuelers), and mechanics who drove and/or worked with alternative fuel vehicles, and the attitudes and perceptions of people with these experiences, are examined. Five alternative fuels studied in the CleanFleet project are considers& compressed natural gas, propane gas, California Phase 2 reformulated gasoline, M-85, and electricity. The three major areas of interest include comparative analysis of issues such as health, safety and vehicle performance, business issues encompassing several facets of station operations, and personal commentary and opinions about the CleanFleet project and the alterative fuels. Results of the employee attitude assessment are presented as both statistical and qualitative analysis.

  13. Actinide partitioning-transmutation program final report. I. Overall assessment

    Energy Technology Data Exchange (ETDEWEB)

    Croff, A.G.; Blomeke, J.O.; Finney, B.C.

    1980-06-01

    This report is concerned with an overall assessment of the feasibility of and incentives for partitioning (recovering) long-lived nuclides from fuel reprocessing and fuel refabrication plant radioactive wastes and transmuting them to shorter-lived or stable nuclides by neutron irradiation. The principal class of nuclides considered is the actinides, although a brief analysis is given of the partitioning and transmutation (P-T) of /sup 99/Tc and /sup 129/I. The results obtained in this program permit us to make a comparison of the impacts of waste management with and without actinide recovery and transmutation. Three major conclusions concerning technical feasibility can be drawn from the assessment: (1) actinide P-T is feasible, subject to the acceptability of fuels containing recycle actinides; (2) technetium P-T is feasible if satisfactory partitioning processes can be developed and satisfactory fuels identified (no studies have been made in this area); and (3) iodine P-T is marginally feasible at best because of the low transmutation rates, the high volatility, and the corrosiveness of iodine and iodine compounds. It was concluded on the basis of a very conservative repository risk analysis that there are no safety or cost incentives for actinide P-T. In fact, if nonradiological risks are included, the short-term risks of P-T exceed the long-term benefits integrated over a period of 1 million years. Incentives for technetium and iodine P-T exist only if extremely conservative long-term risk analyses are used. Further RD and D in support of P-T is not warranted.

  14. Space-reactor electric systems: subsystem technology assessment

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, R.V.; Bost, D.; Determan, W.R.

    1983-03-29

    This report documents the subsystem technology assessment. For the purpose of this report, five subsystems were defined for a space reactor electric system, and the report is organized around these subsystems: reactor; shielding; primary heat transport; power conversion and processing; and heat rejection. The purpose of the assessment was to determine the current technology status and the technology potentials for different types of the five subsystems. The cost and schedule needed to develop these potentials were estimated, and sets of development-compatible subsystems were identified.

  15. Problems of method of technology assessment. A methodological analysis; Methodenprobleme des Technology Assessment; Eine methodologische Analyse

    Energy Technology Data Exchange (ETDEWEB)

    Zimmermann, V.

    1993-03-01

    The study undertakes to analyse the theoretical and methodological structure of Technology Assessment (TA). It is based on a survey of TA studies which provided an important condition for theoreticall sound statements on methodological aspects of TA. It was established that the main basic theoretical problems of TA are in the field of dealing with complexity. This is also apparent in the constitution of problems, the most elementary and central approach of TA. Scientifically founded constitution of problems and the corresponding construction of models call for interdisciplinary scientific work. Interdisciplinarity in the TA research process is achieved at the level of virtual networks, these networks being composed of individuals suited to teamwork. The emerging network structures have an objective-organizational and an ideational basis. The objective-organizational basis is mainly the result of team composition and the external affiliations of the team members. The ideational basis of the virtual network is represented by the team members` mode of thinking, which is individually located at a multidisciplinary level. The theoretical `skeleton` of the TA knowledge system, which is represented by process knowledge based linkage structures, can be generated and also processed in connection with the knowledge on types of problems, areas of analysis and procedures to deal with complexity. Within this process, disciplinary knowledge is a necessary but not a sufficient condition. Metatheoretical and metadisciplinary knowledge and the correspondingly processes complexity of models are the basis for the necessary methodological awareness, that allows TA to become designable as a research procedure. (orig./HP) [Deutsch] Die Studie stellt sich die Aufgabe, die theoretische und methodische Struktur des Technology Assessment (TA) zu analysieren. Sie fusst auf Erhebungen, die bei Technology-Assessment-Studien vorgenommen wurden und die wesentliche Voraussetzungen fuer

  16. Challenges for relative effectiveness assessment and early access of cancer immunotherapies in Europe

    OpenAIRE

    Mira Pavlovic

    2016-01-01

    Clinical endpoints relevant for relative effectiveness assessment (REA) reflect how patients feel, function, or survive. Outcome data requested by Health Technology Assessment (HTA) bodies in Europe to support reimbursement of an anticancer drug are based on final endpoints coming from completed comparative phase 3 trials; overall survival improvement is the preferred criterion for the demonstration of the patient benefit in this field.Recent arrival of new treatments that target identified f...

  17. Challenges for Relative Effectiveness Assessment and Early Access of Cancer Immunotherapies in Europe

    OpenAIRE

    Pavlovic, Mira

    2016-01-01

    Clinical endpoints relevant for relative effectiveness assessment (REA) reflect how patients feel, function, or survive. Outcome data requested by health technology assessment (HTA) bodies in Europe to support reimbursement of an anticancer drug are based on final endpoints coming from completed comparative phase 3 trials; overall survival improvement is the preferred criterion for the demonstration of the patient benefit in this field. Recent arrival of new treatments that target identified ...

  18. RNAi technology: A Revolutionary tool for the colorectal cancer therapeutics

    Institute of Scientific and Technical Information of China (English)

    Wei Lv; Chao Zhang; Jia Hao

    2006-01-01

    With the many changes that have taken place in people's diet and lifestyle, colorectal cancer (CRC) has become a global concern. There were approximately 950000 new cases diagnosed and 500000 deaths recorded worldwide in 2000. It is the second most common type of cancer in the Western world, and it is the third most common type of digestive tumor in China. It is reported that the morbidity of CRC is 4.08/100000 for men and 3.30/100000 for women in China. Despite the rate of improvements in surgery, radiotherapy and chemotherapy, the overall five-year survival is around 50%. Therefore, novel treatment need to be developed in order to add to the therapeutic armamentarium.RNA interference (RNAi) is a sequence-specific posttranscriptional gene silencing mechanism, which is triggered by double-stranded RNA (dsRNA) and causes degradation of mRNA homologous in sequence to the dsRNA.This new approach has been successfully adopted to inhibit virus replication and tumorigenicity. Recent reports have described DNA vector-based strategies for delivery of small interfering RNA (siRNA) into mammalian cells, further expanding the utility of RNAi. With the development of the RNAi technology and deeper understanding of this field, a promising new modality of treatment appeared, which can be used in combination with the existing therapies .We reviewed the proceedings on the actualities and advancement of RNAi technology for colorectal cancer therapeutics.

  19. Redesign and Validation of Sisom, an Interactive Assessment and Communication Tool for Children With Cancer

    Science.gov (United States)

    2016-01-01

    Background Children with cancer undergo intensive and long treatment periods that expose them and their families to a number of difficult physical, mental, and social challenges. Empowering children by actively involving them in their care can help them to cope with these challenges. It can, however, be difficult for children to be involved and talk about their illness experiences in a “traditional” conversation with health care professionals, especially for younger children. Sisom (Norwegian acronym “Si det som det er” or “Tell it how it is”) is an interactive computer-based assessment and communication tool to give children (aged 6-12 years) with cancer a “voice” in their care. Because of technological advances and widespread use of mobile devices Sisom had to be redesigned to better meet the needs of children of today. Objective To redesign Sisom for use on mobile devices and to validate and adapt it for use in a Swedish population of children with cancer. Methods A user-experience design was used. Content adaptation included forward-backward translation by Swedish and Norwegian translators. Healthy children (n=5), children with experiences of cancer treatment (n=5) and their parents (n=5), and pediatric nurses (n=2) were then involved in culturally adapting Sisom to the Swedish context. The iterative low- and high-fidelity evaluation was supported by a think aloud method, semistructured interviews, and drawings to capture children’s views of Sisom. The redesign and evaluation continued until no further changes or improvements were identified by the participants or the researchers. Results Children, parents, and pediatric nurses offered many suggestions for improvements to the original version in terms of content, aesthetics, and usability of Sisom. The most significant change that emerged through user input was a modification that entailed not using problem-focused statements in the assessment items. The parents and pediatric nurses considered

  20. Voice Assessment of Student Work: Recent Studies and Emerging Technologies

    Science.gov (United States)

    Eckhouse, Barry; Carroll, Rebecca

    2013-01-01

    Although relatively little attention has been given to the voice assessment of student work, at least when compared with more traditional forms of text-based review, the attention it has received strongly points to a promising form of review that has been hampered by the limits of an emerging technology. A fresh review of voice assessment in light…

  1. Technology Enhanced Formative Assessment for 21st Century Learning

    Science.gov (United States)

    Spector, J. Michael; Ifenthaler, Dirk; Sampson, Demetrios; Yang, Lan; Mukama, Evode; Warusavitarana, Amali; Dona, Kulari Lokuge; Eichhorn, Koos; Fluck, Andrew; Huang, Ronghuai; Bridges, Susan; Lu, Jiingyan; Ren, Youqun; Gui, Xiaoqing; Deneen, Christopher C.; San Diego, Jonathan; Gibson, David C.

    2016-01-01

    This paper is based on the deliberations of the Assessment Working Group at EDUsummIT 2015 in Bangkok, Thailand. All of the members of Thematic Working Group 5 (TWG5) have contributed to this synthesis of potentials, concerns and issues with regard to the role of technology in assessment as, for and of learning in the 21st century. The group…

  2. Bench-scale co-processing economic assessment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Gala, H.B.; Marker, T.L.; Miller, E.N.

    1994-11-01

    The UOP Co-Processing scheme is a single-stage slurry catalyzed process in which petroleum vacuum resid and coal are simultaneously upgraded to a high-quality synthetic oil. A highly active dispersed catalyst has been developed which enables the operation of the co-processing unit at relatively moderate and high temperatures and relatively high pressure. Under the current contract, a multi-year research program was undertaken to study the technical and economic feasibility of this technology. All the contractual tasks were completed. Autoclave experiments were carried out to evaluate dispersed vanadium catalysts, molybdenum catalysts, and a less costly UOP-proprietary catalyst preparation technique. Autoclave experiments were also carried out in support of the continuous pilot plant unit operation and to study the effects of the process variables (pressure, temperature, and metal loading on the catalyst). A total of 24 continuous pilot plant runs were made. Research and development efforts during the pilot plant operations were concentrated on addressing the cost effectiveness of the UOP single-stage slurry catalyzed co-processing concept based on UOP experience gained in the previous DOE contract. To this end, effect of catalyst metal concentration was studied and a highly-active Mo-based catalyst was developed. This catalyst enabled successful long-term operation (924 hours) of the continuous bench-scale plant at highly severe operating conditions of 3,000 psig, 465{degree}C temperature, and 2:1 resid-to-MAF (moisture- and ash-free) coal ratio with 0.1 wt % active metal. The metal loading of the catalyst was low enough to consider the catalyst as a disposable slurry catalyst. Also, liquid recycle was incorporated in the pilot plant design to increase the, reactor back mixing and to increase the flow of liquid through the reactor (to introduce turbulence in the reactor) and to represent the design of a commercial-scale reactor.

  3. Noninvasive imaging technologies for cutaneous wound assessment: A review.

    Science.gov (United States)

    Paul, Dereck W; Ghassemi, Pejhman; Ramella-Roman, Jessica C; Prindeze, Nicholas J; Moffatt, Lauren T; Alkhalil, Abdulnaser; Shupp, Jeffrey W

    2015-01-01

    The ability to phenotype wounds for the purposes of assessing severity, healing potential and treatment is an important function of evidence-based medicine. A variety of optical technologies are currently in development for noninvasive wound assessment. To varying extents, these optical technologies have the potential to supplement traditional clinical wound evaluation and research, by providing detailed information regarding skin components imperceptible to visual inspection. These assessments are achieved through quantitative optical analysis of tissue characteristics including blood flow, collagen remodeling, hemoglobin content, inflammation, temperature, vascular structure, and water content. Technologies that have, to this date, been applied to wound assessment include: near infrared imaging, thermal imaging, optical coherence tomography, orthogonal polarization spectral imaging, fluorescence imaging, laser Doppler imaging, microscopy, spatial frequency domain imaging, photoacoustic detection, and spectral/hyperspectral imaging. We present a review of the technologies in use or development for these purposes with three aims: (1) providing basic explanations of imaging technology concepts, (2) reviewing the wound imaging literature, and (3) providing insight into areas for further application and exploration. Noninvasive imaging is a promising advancement in wound assessment and all technologies require further validation.

  4. Elaboration and validation of an assistive technology assessment questionnaire

    Directory of Open Access Journals (Sweden)

    Fernanda Jorge Guimarães

    2015-06-01

    Full Text Available Assistive Technologies consists of resources, methods, and strategies favoring autonomy and inclusion of elderly and people with disabilities, being scarce in the literature instruments assessing them. A methodology study conducted with a panel of specialists and people with visual impairment, aimed to elaborate and validate a questionnaire to assess educational assistive technology. To consider an item as valid, we used 80% as agreement percentage, and validity and reliability of the questionnaire were calculated. Assistive Technology was characterized in six attributes: objectives, access, clarity, structure and presentation, relevance and efficacy, interactivity, and 19 items were elaborated to compose the questionnaire. From those, 11 obtained percentages higher than 80%, seven were modified and one was excluded. The instrument Cronbach’s alpha was 0,822, guaranteeing validity and reliability of the tool to assess health education Assistive Technology, and therefore, its use is indicated.

  5. MINI REVIEW - EPIGENETIC PROCESSES AND CANCER RISK ASSESSMENT

    Science.gov (United States)

    Abstract: The U.S. Environmental Protection Agency's Guidelines for Carcinogen Risk Assessment encourages the use of mechanistic data in the assessment of human cancer risk at low (environmental) exposure levels. The key events that define a particular mode of action for tumor fo...

  6. Willow Creek Wildlife Mitigation Project. Final Environmental Assessment.

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    Today`s notice announces BPA`s proposal to fund land acquisition or acquisition of a conservation easement and a wildlife management plan to protect and enhance wildlife habitat at the Willow Creek Natural Area in Eugene, Oregon. This action would provide partial mitigation for wildlife and wildlife habitat lost by the development of Federal hydroelectric projects in the Willamette River Basin. The project is consistent with BPA`s obligations under provisions of the Pacific Northwest Electric Power Planning and Conservation Act of 1980 as outlined by the Northwest Power Planning Council`s 1994 Columbia River Basin Fish and Wildlife Program. BPA has prepared an environmental assessment (DOE/EA-1023) evaluating the proposed project. Based on the analysis in the EA, BPA has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an environmental impact statement (EIS) is not required and BPA is issuing this FONSI.

  7. Final Safety Assessment of Coal Tar as Used in Cosmetics

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    Coal Tar is a semisolid by-product obtained in the destructive distillation of bituminous coal, which functions in cosmetic products as a cosmetic biocide and denaturant-antidandruff agent is also listed as a function, but this is considered an over-the-counter (OTC) drug use. In 2002, Coal Tar was reported to the Food and Drug Administration (FDA) to be used in four formulations, all of which appear to be OTC drug products. Coal Tar is monographed by the FDA as Category I (safe and effective) OTC drug ingredient for use in the treatment of dandruff, seborrhoea, and psoriasis. Coal Tar is absorbed through the skin of animals and humans and is systemically distributed. Although the Cosmetic Ingredient Review (CIR) Expert Panel believes that Coal Tar use as an antidandruff ingredient in OTC drug preparations is adequately addressed by the FDA regulations, the Panel also believes that the appropriate concentration of use of Coal Tar in cosmetic formulations should be that level that does not have a biological effect in the user. Additional data needed to make a safety assessment include product types in which Coal Tar is used (other than as an OTC drug ingredient), use concentrations, and the maximum concentration that does not induce a biological effect in users.

  8. Vehicle technologies heavy vehicle program : FY 2008 benefits analysis, methodology and results --- final report.

    Energy Technology Data Exchange (ETDEWEB)

    Singh, M.; Energy Systems; TA Engineering

    2008-02-29

    This report describes the approach to estimating the benefits and analysis results for the Heavy Vehicle Technologies activities of the Vehicle Technologies (VT) Program of EERE. The scope of the effort includes: (1) Characterizing baseline and advanced technology vehicles for Class 3-6 and Class 7 and 8 trucks, (2) Identifying technology goals associated with the DOE EERE programs, (3) Estimating the market potential of technologies that improve fuel efficiency and/or use alternative fuels, and (4) Determining the petroleum and greenhouse gas emissions reductions associated with the advanced technologies. In FY 08 the Heavy Vehicles program continued its involvement with various sources of energy loss as compared to focusing more narrowly on engine efficiency and alternative fuels. These changes are the result of a planning effort that first occurred during FY 04 and was updated in the past year. (Ref. 1) This narrative describes characteristics of the heavy truck market as they relate to the analysis, a description of the analysis methodology (including a discussion of the models used to estimate market potential and benefits), and a presentation of the benefits estimated as a result of the adoption of the advanced technologies. The market penetrations are used as part of the EERE-wide integrated analysis to provide final benefit estimates reported in the FY08 Budget Request. The energy savings models are utilized by the VT program for internal project management purposes.

  9. Measuring and Assessing Application-Specific Technology Readiness

    Directory of Open Access Journals (Sweden)

    Antonino Ardilio

    2015-11-01

    Full Text Available Technology readiness is a crucial issue for decision-makers in technology-driven enterprises, determining whether the technology will or won’t be adopted for use in products or as a process technology. We know that, in some cases, lower technology readiness will be accepted by the users; these could be end-users, but, more often, it will be used in companies. The impact of a too early or too late adopted technology can be huge for companies and can even threaten market position or the existence of the company itself. Research institutes and technology developers, in particular application-oriented research organizations, might be also interested in which parameters or technology attributes should be improved or extended, according to the addressed application field, so that the technology fulfils the market-requested functions and a fast diffusion in the market can be achieved. Existing technology readiness models cover the various usages of the technology. In many cases, they assess the technology’s use in across different industries and application fields. However, the requirements in many fields are mostly different and very specific; thus, evaluation at such a high level can’t conclude whether the technology should be considered and adopted in the applications involved. This paper introduces an approach on how to determine and map the application-specific readiness of technology by decomposing both the application and the technology into its requested functions, as well as dynamically mapping the individual technology performance criteria. The applicability of this model will be demonstrated and discussed by a use case in the area of OLED-technology.

  10. Phase shifter technology assessment - Prospects and applications

    Science.gov (United States)

    Sokolov, Vladimir

    1991-01-01

    Capabilities and limitations of MMIC phase shifter technology at microwave and millimeter wave frequencies are reviewed. MMIC-based phase arrays make it possible to integrate active elements at the array face, i.e., to incorporate transmit power amplifiers and/or low noise amplifiers at each antenna element. Active elements make it possible to increase power efficiency and reliability and provide graceful degradation. Monolithic integration of the various transmit/receive functions including phase shifting is considered to be feasible through at least the lower millimeter-wave frequency range (about 30-100 GHz). MMIC integration also allows more flexibility in array design including those that are intended for airborne conformal applications.

  11. Emerging frontier technologies for food safety analysis and risk assessment

    Institute of Scientific and Technical Information of China (English)

    DONG Yi-yang; LIU Jia-hui; WANG Sai; CHEN Qi-long; GUO Tian-yang; ZHANG Li-ya; JIN Yong; SU Hai-jia; TAN Tian-wei

    2015-01-01

    Access to security and safe food is a basic human necessity and essential for a sustainable world. To perform hi-end food safety analysis and risk assessment with state of the art technologies is of utmost importance thereof. With applications as exempliifed by microlfuidic immunoassay, aptasensor, direct analysis in real time, high resolution mass spectrometry, benchmark dose and chemical speciifc adjustment factor, this review presents frontier food safety analysis and risk assess-ment technologies, from which both food quality and public health wil beneift undoubtedly in a foreseeable future.

  12. Final Environmental Assessment : Livestock Grazing Management Seven Blackfeet Habitat Unit : Charles M. Russell National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Final environmental assessment for the grazing management within the Seven Blackfeet Habitat Unit of the Charles M. Russell National Wildlife Refuge, in relation to...

  13. Next Generation Risk Assessment: Incorporation of Recent Advances in Molecular, Computational, and Systems Biology (Final Report)

    Science.gov (United States)

    EPA announced the release of the final report, Next Generation Risk Assessment: Incorporation of Recent Advances in Molecular, Computational, and Systems Biology. This report describes new approaches that are faster, less resource intensive, and more robust that can help ...

  14. Final Environmental Assessment for the Proposed Wallkill River National Wildlife Refuge 1990

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Final Environmental Assessment for the proposed acquisition and establishment of Wallkill River National Wildlife Refuge in Sussex Country, New Jersey. The...

  15. Reactor technology assessment and selection utilizing systems engineering approach

    Science.gov (United States)

    Zolkaffly, Muhammed Zulfakar; Han, Ki-In

    2014-02-01

    The first Nuclear power plant (NPP) deployment in a country is a complex process that needs to consider technical, economic and financial aspects along with other aspects like public acceptance. Increased interest in the deployment of new NPPs, both among newcomer countries and those with expanding programs, necessitates the selection of reactor technology among commercially available technologies. This paper reviews the Systems Decision Process (SDP) of Systems Engineering and applies it in selecting the most appropriate reactor technology for the deployment in Malaysia. The integrated qualitative and quantitative analyses employed in the SDP are explored to perform reactor technology assessment and to select the most feasible technology whose design has also to comply with the IAEA standard requirements and other relevant requirements that have been established in this study. A quick Malaysian case study result suggests that the country reside with PWR (pressurized water reactor) technologies with more detailed study to be performed in the future for the selection of the most appropriate reactor technology for Malaysia. The demonstrated technology assessment also proposes an alternative method to systematically and quantitatively select the most appropriate reactor technology.

  16. Final report on the safety assessment of phytantriol.

    Science.gov (United States)

    2007-01-01

    Phytantriol is an alcohol used in around 100 cosmetic products at concentrations ranging from 0.0002% to 1.0%, although uses at concentrations up to 3% are under development. Phytanriol is supplied at 95.2% and 96.0% purity. Impurities include water, sulphated ash, heavy metals, and a diastereomer of Phytantriol, 3,7,11,15-tetramethyl-1,2,3,4-tetrahydroxyhexadecane. Dermal penetration is low; skin permeability was calculated as log Kp = - 1.734. Oral LD50 values in mice and rats were reported to be > 5000 mg/kg. Ocular application of 100% Phytantriol did cause severe corneal damage in some animals, at 23% in diethyl phthalate only slight corneal opacity was seen, and at 10% transient opacity was seen, which resolved by 48 h. Phytantriol at 100% was a severe skin irritant in animal tests. Phytantriol at 3% and 10% in diethyl phthalate produced only slight erythema, which cleared by 48 h. Phytantriol, in the Longhorn egg chorioallantoic membrane assay, was found to have almost no irritation potential when tested at 3% concentration in corn oil. Phytantriol at 25% did produce sensitization in a maximization test, but concentrations of 1% and lower did not cause a sensitization response. Phytantriol is neither phototoxic nor photoallergenic. Phytantriol did not induce aberrations in cultured human lymphocytes, when tested within cytotoxicity limits, nor was it mutagenic in Ames tests, with or without metabolic activation. None of 101 human volunteers reacted initially or to challenge patches of 3% Phytantriol in corn oil. In another investigation of 227 volunteers induced and challenged with 3% Phytantriol in 70:30 ethyl alcohol/water, one person had a mild reaction to the first induction patch; this was the only positive reaction during the induction and challenge phases for all of the volunteers. Phytantriol had no adverse effects in any of 206 volunteer subjects in a repeat insult patch test at 5%. Although data were not available with which to assess reproductive

  17. DOE SciDAC's Earth System Grid Center for Enabling Technologies Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Dean N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2011-09-27

    Computing Centre, the National Aeronautics and Space Administration Jet Propulsion Laboratory, and the National Oceanic and Atmospheric Administration. The ESGF software is distinguished from other collaborative knowledge systems in the climate community by its widespread adoption, federation capabilities, and broad developer base. It is the leading source for present climate data holdings, including the most important and largest data sets in the global-climate community, and - assuming its development continues - we expect it to be the leading source for future climate data holdings as well. Recently, ESG-CET extended its services beyond data-file access and delivery to include more detailed information products (scientific graphics, animations, etc.), secure binary data-access services (based upon the OPeNDAP protocol), and server-side analysis. The latter capabilities allow users to request data subsets transformed through commonly used analysis and intercomparison procedures. As we transition from development activities to production and operations, the ESG-CET team is tasked with making data available to all users seeking to understand, process, extract value from, visualize, and/or communicate it to others. This ongoing effort, though daunting in scope and complexity, will greatly magnify the value of numerical climate model outputs and climate observations for future national and international climate-assessment reports. The ESG-CET team also faces substantial technical challenges due to the rapidly increasing scale of climate simulation and observational data, which will grow, for example, from less than 50 terabytes for the last Intergovernmental Panel on Climate Change (IPCC) assessment to multiple Petabytes for the next IPCC assessment. In a world of exponential technological change and rapidly growing sophistication in climate data analysis, an infrastructure such as ESGF must constantly evolve if it is to remain relevant and useful. Regretfully, we submit our

  18. FINAL REPORT ON THE AQUATIC MERCURY ASSESSMENT STUDY

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, N

    2008-09-30

    In February 2000, the United States Environmental Protection Agency (EPA) Region 4 issued a proposed Total Maximum Daily Load (TMDL) for total mercury in the middle and lower Savannah River. The initial TMDL, which would have imposed a 1 ng/l mercury limit for discharges to the middle/lower Savannah River, was revised to 2.8 ng/l in the final TMDL released in February 2001. The TMDL was intended to protect people from the consumption of contaminated fish, which is the major route of mercury exposure to humans. The most bioaccumulative form of mercury is methylmercury, which is produced in aquatic environments by the action of microorganisms on inorganic mercury. Because of the environmental and economic significance of the mercury discharge limits that would have been imposed by the TMDL, the Savannah River Site (SRS) initiated several studies concerning: (1) mercury in SRS discharges, SRS streams and the Savannah River, (2) mercury bioaccumulation factors for Savannah River fish, (3) the use of clams to monitor the influence of mercury from tributary streams on biota in the Savannah River, and (4) mercury in rainwater falling on the SRS. The results of these studies are presented in detail in this report. The first study documented the occurrence, distribution and variation of total and methylmercury at SRS industrial outfalls, principal SRS streams and the Savannah River where it forms the border with the SRS. All of the analyses were performed using the EPA Method 1630/31 ultra low-level and contaminant-free techniques for measuring total and methylmercury. Total mercury at National Pollutant Discharge Elimination System (NPDES) outfalls ranged from 0.31-604 ng/l with a mean of 8.71 ng/l. Mercury-contaminated groundwater was the source for outfalls with significantly elevated mercury concentrations. Total mercury in SRS streams ranged from 0.95-15.7 ng/l. Mean total mercury levels in the streams varied from 2.39 ng/l in Pen Branch to 5.26 ng/l in Tims Branch

  19. Final report on the safety assessment of polyethylene.

    Science.gov (United States)

    2007-01-01

    , was a mild irritant when tested as a solid material in the eyes of rabbits. Rabbit eyes treated with a solution containing 13% Polyethylene beads produced minimal irritation and no corneal abrasions. No genotoxicity was found in bacterial assays. No chemical carcinogenicity has been seen in implantation studies, although particles from Polyethylene implants can induce so-called solid-state carcinogenicity, which is a physical reaction to an implanted material. Occupational case reports of ocular irritation and systemic sclerosis in workers exposed to Polyethylene have been difficult to interpret because such workers are also exposed to other irritants. Clinical testing of intrauterine devices made of Polyethylene failed to conclusively identify statistically significant adverse effects, although squamous metaplasia was observed. The Cosmetic Ingredient Review (CIR) Expert Panel did not expect significant dermal absorption and systemic exposure to large Polyethylene polymers used in cosmetics. The Panel was concerned that information on impurities, including residual catalyst and reactants from the polymerization process, was not available. The Panel considered that the monomer unit in Polyethylene polymerization is ethylene. In the United States, ethylene is 99.9% pure. The other 0.1% includes ethane, propylene, carbon dioxide, carbon monoxide, sulfur, hydrogen, acetylene, water, and oxygen. The Panel believed that the concentration of these impurities in any final polymer would be so low as to not raise toxicity issues. Safety tests of cosmetic-grade Polyethylene have consistently failed to identify any toxicity associated with residual catalyst. Although it was reported that one process used to cross-link Polyethylene with an organic peroxide, this process is not currently used. In addition, cosmetic-grade Polyethylene is not expected to contain toxic hexanes. The Panel was concerned that the only genotoxicity data available was nonmammalian, but taking this

  20. Validation of the Proficiency Examination for Diagnostic Radiologic Technology. Final Report.

    Science.gov (United States)

    Educational Testing Service, Princeton, NJ.

    The validity of the Proficiency Examination for Diagnostic Radiologic Technology was investigated, using 140 radiologic technologists who took both the written Proficiency Examination and a performance test. As an additional criterion measure of job proficiency, supervisors' assessments were obtained for 128 of the technologists. The resulting…

  1. Optimizing HER2 assessment in breast cancer

    DEFF Research Database (Denmark)

    Holten-Rossing, Henrik; Møller Talman, Maj-Lis; Kristensson, Martin

    2015-01-01

    In breast cancer, analysis of HER2 expression is pivotal for treatment decision. This study aimed at comparing digital, automated image analysis with manual reading using the HER2-CONNECT algorithm (Visiopharm) in order to minimize the number of equivocal 2+ scores and the need for reflex...

  2. Particle radiotherapy emerging technology for treatment of cancer

    CERN Document Server

    Sahoo, Narayan

    2016-01-01

    The results of decades of research and development are providing compelling evidence about the efficacy of radiation therapy with proton and carbon ion beams to achieve superior complication free tumor control leading to a world-wide rapid growth in their clinical use. This book contains comprehensive reviews of the state of the art of the technology and physics of heavy charge particle therapy by the experts from the leading cancer centers of world that will be valuable as a practical guide for radiation therapy professionals interested in these modalities.

  3. Communication and technology in genetic counseling for familial cancer.

    Science.gov (United States)

    Lynch, H T; Snyder, C; Stacey, M; Olson, B; Peterson, S K; Buxbaum, S; Shaw, T; Lynch, P M

    2014-03-01

    When a cancer predisposing germline mutation is detected in an index case, the presence of the underlying syndrome is confirmed and the potential for predictive testing of at-risk relatives is established. However, the reporting of a positive family history does not routinely lead to communication of information about risk to close, much less distant relatives. This review summarizes information technology utilized to address penetration or 'reach' of knowledge of risk within extended families, including the use of telephone and video counseling to reach distant patients, and anticipate novel internet-based processes for communication between investigators and relatives.

  4. Application of phage display technology in targeted therapy of breast cancer

    Institute of Scientific and Technical Information of China (English)

    Mian Kong; Junye Wang; Baojiang Li

    2013-01-01

    Phage display is a technology of gene expression and screening, it is widely used in the fields of defining antigenepitopes, signal transduction, genetic treatment, parasites research and tumor targeted therapy. Breast cancer is the mostcommon cancer in women, we can obtain peptides specially associated with breast cancer by using phage display technology,and this method has great potential in early diagnosis of breast cancer and development new targeted drugs.

  5. Final report of the safety assessment of Urea.

    Science.gov (United States)

    2005-01-01

    alone or with other agents in treatment of diseased skin. Overall, there are few reports of sensitization among the many clinical studies that report use of Urea in treatment of diseased skin. The Cosmetic Ingredient Review (CIR) Expert Panel determined the data provided in this report to be sufficient to assess the safety of Urea. The Panel did note that Urea can cause uncoiling of DNA, a property used in many DNA studies, but concluded that this in vitro activity is not linked to any in vivo genotoxic activity. Although noting that formulators should be aware that Urea can increase the percutaneous absorption of other chemicals, the CIR Expert Panel concluded that Urea is safe as used in cosmetic products.

  6. Mastoidectomy performance assessment of virtual simulation training using final-product analysis

    DEFF Research Database (Denmark)

    Andersen, Steven A W; Cayé-Thomasen, Per; Sørensen, Mads S

    2015-01-01

    in virtual simulation and traditional dissection training. STUDY DESIGN: Prospective trial with blinding. METHODS: A total of 34 novice residents performed a mastoidectomy on the Visible Ear Simulator and on a cadaveric temporal bone. Two blinded senior otologists assessed the final-product performance using.......59) for dissection final-product assessment was found. The simulation and dissection performance scores had significant correlation (P = .014). None of the basic simulator metrics correlated significantly with the final-product score except for number of steps completed in the simulator. CONCLUSIONS: A modified...

  7. The contribution of health technology assessment, health needs assessment, and health impact assessment to the assessment and translation of technologies in the field of public health genomics.

    Science.gov (United States)

    Rosenkötter, N; Vondeling, H; Blancquaert, I; Mekel, O C L; Kristensen, F B; Brand, A

    2011-01-01

    The European Union has named genomics as one of the promising research fields for the development of new health technologies. Major concerns with regard to these fields are, on the one hand, the rather slow and limited translation of new knowledge and, on the other hand, missing insights into the impact on public health and health care practice of those technologies that are actually introduced. This paper aims to give an overview of the major assessment instruments in public health [health technology assessment (HTA), health needs assessment (HNA) and health impact assessment (HIA)] which could contribute to the systematic translation and assessment of genomic health applications by focussing at population level and on public health policy making. It is shown to what extent HTA, HNA and HIA contribute to translational research by using the continuum of translational research (T1-T4) in genomic medicine as an analytic framework. The selected assessment methodologies predominantly cover 2 to 4 phases within the T1-T4 system. HTA delivers the most complete set of methodologies when assessing health applications. HNA can be used to prioritize areas where genomic health applications are needed or to identify infrastructural needs. HIA delivers information on the impact of technologies in a wider scope and promotes informed decision making. HTA, HNA and HIA provide a partly overlapping and partly unique set of methodologies and infrastructure for the translation and assessment of genomic health applications. They are broad in scope and go beyond the continuum of T1-T4 translational research regarding policy translation.

  8. Technological and life cycle assessment of organics processing odour control technologies

    Energy Technology Data Exchange (ETDEWEB)

    Bindra, Navin [School of Engineering, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G2W1 (Canada); Dubey, Brajesh, E-mail: bkdubey@civil.iitkgp.ernet.in [School of Engineering, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G2W1 (Canada); Environmental Engineering Division, Department of Civil Engineering, Indian Institute of Technology, Kharagpur, West Bengal 721302 (India); Dutta, Animesh [School of Engineering, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G2W1 (Canada)

    2015-09-15

    As more municipalities and communities across developed world look towards implementing organic waste management programmes or upgrading existing ones, composting facilities are emerging as a popular choice. However, odour from these facilities continues to be one of the most important concerns in terms of cost & effective mitigation. This paper provides a technological and life cycle assessment of some of the different odour control technologies and treatment methods that can be implemented in organics processing facilities. The technological assessment compared biofilters, packed tower wet scrubbers, fine mist wet scrubbers, activated carbon adsorption, thermal oxidization, oxidization chemicals and masking agents. The technologies/treatment methods were evaluated and compared based on a variety of operational, usage and cost parameters. Based on the technological assessment it was found that, biofilters and packed bed wet scrubbers are the most applicable odour control technologies for use in organics processing faculties. A life cycle assessment was then done to compare the environmental impacts of the packed-bed wet scrubber system, organic (wood-chip media) bio-filter and inorganic (synthetic media) bio-filter systems. Twelve impact categories were assessed; cumulative energy demand (CED), climate change, human toxicity, photochemical oxidant formation, metal depletion, fossil depletion, terrestrial acidification, freshwater eutrophication, marine eutrophication, terrestrial eco-toxicity, freshwater eco-toxicity and marine eco-toxicity. The results showed that for all impact categories the synthetic media biofilter had the highest environmental impact, followed by the wood chip media bio-filter system. The packed-bed system had the lowest environmental impact for all categories. - Highlights: • Assessment of odour control technologies for organics processing facilities. • Comparative life cycle assessment of three odour control technologies was conducted

  9. Program Final Report - Develop Thermoelectric Technology for Automotive Waste Heat Recovery

    Energy Technology Data Exchange (ETDEWEB)

    Gregory Meisner

    2011-08-31

    We conducted a vehicle analysis to assess the feasibility of thermoelectric technology for waste heat recovery and conversion to useful electrical power and found that eliminating the 500 W of electrical power generated by the alternator corresponded to about a 7% increase in fuel economy (FE) for a small car and about 6% for a full size truck. Electric power targets of 300 W were established for city and highway driving cycles for this project. We obtained critical vehicle level information for these driving cycles that enabled a high-level design and performance analysis of radiator and exhaust gas thermoelectric subsystems for several potential vehicle platforms, and we identified the location and geometric envelopes of the radiator and exhaust gas thermoelectric subsystems. Based on this analysis, we selected the Chevrolet Suburban as the most suitable demonstration vehicle for this project. Our modeling and thermal analysis assessment of a radiator-based thermoelectric generator (TEG), however, revealed severe practical limitations. Specifically the small temperature difference of 100°C or less between the engine coolant and ambient air results in a low Carnot conversion efficiency, and thermal resistance associated with air convection would reduce this conversion efficiency even further. We therefore decided not to pursue a radiator-based waste heat recovery system and focused only on the exhaust gas. Our overall approach was to combine science and engineering: (1) existing and newly developed TE materials were carefully selected and characterized by the material researcher members of our team, and most of the material property results were validated by our research partners, and (2) system engineers worked closely with vehicle engineers to ensure that accurate vehicle-level information was used for developing subsystem models and designs, and the subsystem output was analyzed for potential fuel economy gains. We incorporated material, module, subsystem

  10. 77 FR 40893 - U.S. Extractive Industries Transparency Initiative Final Stakeholder Assessment and Multi...

    Science.gov (United States)

    2012-07-11

    ....S. Extractive Industries Transparency Initiative Final Stakeholder Assessment and Multi-Stakeholder... (CBI), to conduct a stakeholder assessment as part of the U.S. Extractive Industries Transparency... regarding options for forming a U.S. multi-stakeholder group that will be responsible for determining...

  11. EPA Releases Final Risk Assessment for Chemical used for Paint and Coating Removal

    Science.gov (United States)

    WASHINGTON - Today, the U.S. EPA released the final risk assessment for N-Methylpyrrolidone (NMP), a chemical commonly used to remove paint and other coatings. The assessment identified risks to pregnant women and women of childbearing age, who have

  12. Technology Assessment Tool - An Application of Systems Engineering to USDOE Technology Proposals

    Energy Technology Data Exchange (ETDEWEB)

    Rynearson, Michael Ardel

    1999-06-01

    This paper discusses the system design for a Technology Assessment (TA) tool that can be used to quantitatively evaluate new and advanced technologies, products, or processes. Key features of the tool include organization of information in an indentured hierarchy; questions and categories derived from the decomposition of technology performance; segregation of life-cycle issues into six assessment categories; and scoring, relative impact, and sensitivity analysis capability. An advantage of the tool's use is its ability to provide decision analysis data, based on incomplete or complete data.

  13. Technology Assessment Tool - An Application of Systems Engineering to USDOE Technology Proposals

    Energy Technology Data Exchange (ETDEWEB)

    M. A. Rynearson

    1999-06-01

    This paper discusses the system design of a Technology Assessment (TA) tool that can be used to quantitatively evaluate new and advanced technologies, products, or processes. Key features of the tool include organization of information in an indentured hierarchy; questions and categories derived from the decomposition of technology performance; segregation of life-cycle issues into six assessment categories; and scoring, relative impact, and sensitivity analysis capability. An advantage of the tool's use is its ability to provide decision analysis data, based on incomplete or complete data.

  14. Nutrition and health technology assessment: when two worlds meet

    OpenAIRE

    Poley, Marten J.

    2015-01-01

    There is a growing recognition that nutrition may have a positive impact on public health and that it may reduce medical expenditures. Yet, such claims need to be substantiated by evidence. This evidence could be delivered by health technology assessment (HTA), which can be thought of as the evaluation of technologies for clinical effectiveness, cost-effectiveness, and ethical, legal, and social impacts. The application of HTA to the field of “nutrition interventions” is recent. So far, HTA a...

  15. Assessment of uncertainties in risk analysis of chemical establishments. The ASSURANCE project. Final summary report

    DEFF Research Database (Denmark)

    Lauridsen, K.; Kozine, Igor; Markert, Frank;

    2002-01-01

    This report summarises the results obtained in the ASSURANCE project (EU contract number ENV4-CT97-0627). Seven teams have performed risk analyses for the same chemical facility, an ammonia storage. The EC's Joint Research Centre at Ispra and RisøNational Laboratory co-ordinated the exercise...... on the ranking among the adherents of the probabilistic approach. Breaking down the modelling of both frequencyand consequence assessments into suitably small elements and conducting case studies allowed identifying root causes of uncertainty in the final risk assessments. Large differences were found in both...... the frequency assessments and in the assessment ofconsequences. The report gives a qualitative assessment of the importance to the final calculated risk of uncertainties in assumptions made, in the data and the calculation methods used. This assessment can serve as a guide to areas where, in particular...

  16. BBN-Based Portfolio Risk Assessment for NASA Technology R&D Outcome

    Science.gov (United States)

    Geuther, Steven C.; Shih, Ann T.

    2016-01-01

    The NASA Aeronautics Research Mission Directorate (ARMD) vision falls into six strategic thrusts that are aimed to support the challenges of the Next Generation Air Transportation System (NextGen). In order to achieve the goals of the ARMD vision, the Airspace Operations and Safety Program (AOSP) is committed to developing and delivering new technologies. To meet the dual challenges of constrained resources and timely technology delivery, program portfolio risk assessment is critical for communication and decision-making. This paper describes how Bayesian Belief Network (BBN) is applied to assess the probability of a technology meeting the expected outcome. The network takes into account the different risk factors of technology development and implementation phases. The use of BBNs allows for all technologies of projects in a program portfolio to be separately examined and compared. In addition, the technology interaction effects are modeled through the application of object-oriented BBNs. The paper discusses the development of simplified project risk BBNs and presents various risk results. The results presented include the probability of project risks not meeting success criteria, the risk drivers under uncertainty via sensitivity analysis, and what-if analysis. Finally, the paper shows how program portfolio risk can be assessed using risk results from BBNs of projects in the portfolio.

  17. Assessment of a satellite power system and six alternative technologies

    Energy Technology Data Exchange (ETDEWEB)

    Wolsko, T.; Whitfield, R.; Samsa, M.; Habegger, L.S.; Levine, E.; Tanzman, E.

    1981-04-01

    The satellite power system is assessed in comparison to six alternative technologies. The alternatives are: central-station terrestrial photovoltaic systems, conventional coal-fired power plants, coal-gasification/combined-cycle power plants, light water reactor power plants, liquid-metal fast-breeder reactors, and fusion. The comparison is made regarding issues of cost and performance, health and safety, environmental effects, resources, socio-economic factors, and insitutional issues. The criteria for selecting the issues and the alternative technologies are given, and the methodology of the comparison is discussed. Brief descriptions of each of the technologies considered are included. (LEW)

  18. Guidelines for the assessment and optimization of turboexpansion technologies

    Energy Technology Data Exchange (ETDEWEB)

    Albrecht, Philipp; Mastandrea, Martin [TECNA Estudios y Proyectos de Ingenieria S.A. (Argentina)

    2004-07-01

    The operating performance of a turbo expansion process depends on several factors among which we find: pressure, temperature and feed stream composition, expected recovery, pressure required for residual gas and products' specifications. The evolution of markets has set the development of several technologies; it is therefore complex, and rather impossible, to establish which of those technologies represents the most suitable choice for certain conditions by simply inspecting the above-mentioned factors. Guidelines for the assessment and optimization of available technologies are presented in this work. Also, relevant matters to be taken into account in the development of different units of a turbo expansion plant are mentioned. (author)

  19. The impact of new technology on surgery for colorectal cancer

    Institute of Scientific and Technical Information of China (English)

    Gregory B Makin; David J Breen; John RT Monson

    2001-01-01

    Advances in technology continue at a rapid pace and affect all aspects of life, including surgery. We have reviewed some of these advances and the impact they are having on the investigation and management of colorectal cancer. Modern endoscopes, with magnifying, variable stiffness and Iocalisation capabilities are making the primary investigation of colonic cancer easier and more acceptable for patients. Imaging investigations looking at primary, metastatic and recurrent disease are shifting to digital data sets. which can he stored, reviewed remotely, potentially fused with other modalities and reconstructed as 3 dimensional (3D) images for the purposes of advanced diagnostic interpretation and computer assisted surgery. They include virtual colonoscopy, trans-rectal ultrasound, magnetic resonance imaging, positron emission tomography and radioimmunoscintigraphy. Once a colorectal carcinoma is diagnosed, the treatment options available are expanding.Colonic stents are being used to relieve large bowel obstruction, either as a palliative measure or to improve the patient's overall condition before definitive surgery.Transenal endoscopic microsurgery and minimally invasive techniques are being used with similar outcomes and a lower mortality, morbidity and hospital stay than open trans-abdominal surgery. Transanal endoscopic microsurgery allows precise excision of both benign and early malignant lesions in the mid and upper rectum.Survival of patients with inoperable hepatic metastases following radiofrequency ablation is encouraging.Robotics and telemedicine are taking surgery well into the 21st century. Artificial neural networks are being developed to enable us to predict the outcome for individual patients. New technology has a major impact on the way we practice surgery for colorectal cancer.``

  20. [High-intensity focused ultrasound and prostate cancer: technology, state of the art and future].

    Science.gov (United States)

    Vespasiani, G; Asimakopoulos, A D; Finazzi Agrò, E; Virgili, G

    2008-01-01

    BACKGROUND. The potential applications of the high-intensity focused ultrasound (HIFU) as a minimally invasive therapy of the localized prostate cancer explain the growing interest of the urologic community towards this technique. HIFU has been assessed for its role in the treatment of localized prostate cancer in patients who otherwise would not have benefited from surgery, and in local recurrences after radiation failure. Methods. Relevant information on HIFU treatment was identified through a literature search of published studies. RESULTS. High biochemical efficacy, excellent tumor local control and favorable mid- and long-term oncological data with a low morbidity rate have been shown in many series of patients. CONCLUSIONS. Although HIFU is a recent and emerging technology, it has been well studied and developed to a point that HIFU will undoubtedly be an effective alternative to radiation therapy.

  1. Sustainability assessment of tertiary wastewater treatment technologies: a multi-criteria analysis.

    Science.gov (United States)

    Plakas, K V; Georgiadis, A A; Karabelas, A J

    2016-01-01

    The multi-criteria analysis gives the opportunity to researchers, designers and decision-makers to examine decision options in a multi-dimensional fashion. On this basis, four tertiary wastewater treatment (WWT) technologies were assessed regarding their sustainability performance in producing recycled wastewater, considering a 'triple bottom line' approach (i.e. economic, environmental, and social). These are powdered activated carbon adsorption coupled with ultrafiltration membrane separation (PAC-UF), reverse osmosis, ozone/ultraviolet-light oxidation and heterogeneous photo-catalysis coupled with low-pressure membrane separation (photocatalytic membrane reactor, PMR). The participatory method called simple multi-attribute rating technique exploiting ranks was employed for assigning weights to selected sustainability indicators. This sustainability assessment approach resulted in the development of a composite index as a final metric, for each WWT technology evaluated. The PAC-UF technology appears to be the most appropriate technology, attaining the highest composite value regarding the sustainability performance. A scenario analysis confirmed the results of the original scenario in five out of seven cases. In parallel, the PMR was highlighted as the technology with the least variability in its performance. Nevertheless, additional actions and approaches are proposed to strengthen the objectivity of the final results.

  2. Noninvasive assessment of breast cancer risk using time-resolved diffuse optical spectroscopy

    Science.gov (United States)

    Taroni, Paola; Pifferi, Antonio; Quarto, Giovanna; Spinelli, Lorenzo; Torricelli, Alessandro; Abbate, Francesca; Villa, Anna; Balestreri, Nicola; Menna, Simona; Cassano, Enrico; Cubeddu, Rinaldo

    2010-11-01

    Breast density is a recognized strong and independent risk factor for breast cancer. We propose the use of time-resolved transmittance spectroscopy to estimate breast tissue density and potentially provide even more direct information on breast cancer risk. Time-resolved optical mammography at seven wavelengths (635 to 1060 nm) is performed on 49 subjects. Average information on breast tissue of each subject is obtained on oxy- and deoxyhemoglobin, water, lipids, and collagen content, as well as scattering amplitude and power. All parameters, except for blood volume and oxygenation, correlate with mammographic breast density, even if not to the same extent. A synthetic optical index proves to be quite effective in separating different breast density categories. Finally, the estimate of collagen content as a more direct means for the assessment of breast cancer risk is discussed.

  3. Assessment of Breast Cancer Risk and Belief in Breast Cancer Screening Among the Primary Healthcare Nurses.

    Science.gov (United States)

    İz, Fatma Başalan; Tümer, Adile

    2016-09-01

    Breast cancer is the most frequently diagnosed cancer in women. Early detection of breast cancer is known to increase survival rates significantly after diagnosis. This research was carried out to determine the level of breast cancer risk among primary healthcare nurses and their belief in breast cancer screening. In this descriptive research, the data were collected in face-to-face interviews with the participants. The researchers contacted all primary healthcare nurses currently working in the province. The data collection tools included a questionnaire form on sociodemographic characteristics, breast cancer risk assessment form, and Champion's Health Belief Model Scale (CHBMS) for breast cancer screening. In data analysis, descriptive statistics, t test, and analysis of variance (ANOVA) were used. The mean age of nurses was 35 ± 3.6. The mean score for the breast cancer risk assessment form was calculated as 82.9 ± 18.7. The subscale scores for the CHBMS for breast cancer screening were as follows: susceptibility 7.3 ± 1.8, seriousness 19.5 ± 4.1, benefits of breast self-exam 15.5 ± 2.6, barriers to breast self-exam 15.1 ± 2.8, self-efficacy 40.3 ± 7.0, and motivation 19.5 ± 4.1. The risk of breast cancer was found to be low in the study group. The analysis of the subscale scores for the CHBMS for breast cancer screening revealed that nurses had a below-average susceptibility perception, a somewhat lower perception of seriousness, an above-average mean score for perceived benefits, a moderate barrier perception, a relatively high perceived self-efficacy, and motivation above average.

  4. Multidimensional assessment of psychological problems in children with cancer.

    Science.gov (United States)

    Armstrong, G D; Wirt, R D; Nesbit, M E; Martinson, I M

    1982-12-01

    The Personality Inventory for Children (PIC) was administered to 88 children 3 to 16 years of age who had cancer. A variety of dimensions of psychological adjustment of these children, who were compared with a sample of nonsick children, was assessed. The PIC indicated that children with cancer exhibited cognitive development-related problems and internalized forms of psychopathology more often than their age- and sex-matched cohorts. In the cancer sample, no differences in problems as a function of diagnoses were observed when controlling for age of the child. No differences related to length of time since diagnosis were observed when controlling for age of the child. About 26% of the children with cancer exhibited PIC profiles indicating problems of such magnitude that professional intervention would be appropriate.

  5. Readings in technology assessment. [in relation to social impact and the law

    Science.gov (United States)

    1975-01-01

    Papers are presented which reflect research in the following areas: development of the concept of technology assessment; institutionalization of technology assessment; the interface between law and technology assessment; and assessment case studies. Case studies include hazards of the medical use of X-rays, environmental noise effects in transportation planning, genetic technology, impact of underground coal mining, and aircraft/airport noise abatement.

  6. [Assessment of screening in women cancers and in 75 years older in Loire department].

    Science.gov (United States)

    Swalduz, Aurélie; Guibert, Cyril; Trone, Jane-Chloé; Guichard, Jean-Baptiste; Rivoirard, Romain; Pacaut, Cécile; Méry, Benoîte; Guy, Jean-Baptiste; Eddekkaoui, Houda; Fournel, Pierre; de Laroche, Guy; Merrouche, Yacine; Magné, Nicolas

    2014-09-01

    In France, there is an important interregional disparity concerning participation to cancer screening programs. The aim of this study was to assess oncologic screening practices in Loire, a French rural department, in women and in the elderly (over age 74 years). For this, two surveys were conducted. The first one was regarding screening for breast, cervical and colorectal cancer in women over age 18 years living in Loire. The second survey was regarding onco-geriatric screening through two questionnaires : one for the elderly and the other for general practitioner (GP) of the department, evaluating screening for breast, colorectal, prostate, cervical and lung cancer. One hundred sixty six women were included in the first investigation mean age of 47.6 years. Ninety three point six per cent were screening for breast cancer, 19% received Human Papilloma virus vaccine, 83.1% were screening by Papanicolau smear for cervical cancer and finally, 51.7% were screening for colorectal cancer, among the one entering screening program criteria. In the second survey, 44 patients and 28 GP were included. Thirty-eight point six per cent of patients over 74 years continue screening. Only 11.4% were reluctant to screening and in 80% because of anxiety du to the results. Among GP, 50 % continued screening on two major criteria : life expectancy and performans status. The present study shows heterogeneity of screening in this department both rural and working class and gives us a societo-medical photography.

  7. Development of a Hydrologic Characterization Technology for Fault Zones Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Karasaki, Kenzi [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Onishi, Celia Tiemi [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Doughty, Christine [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Conrad, Mark [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Gasperikova, Erika [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Cook, Paul [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Ulrich, Craig [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2012-03-31

    This is the final report for the five-year program of the NUMO-LBNL collaborative project (hereafter called the Project): Development of Hydrologic Characterization Technology for Fault Zones, under a NUMO-DOE/LBNL collaboration agreement. Detailed results from the past four years of study can be found in the each year’s year-end report (Karasaki et al., 2008, 2009, 2010, and 2011; Kiho et al., 2008, 2009, 2010, and 2011). In this report, we discuss the results of the studies conducted in FY2011. We also give a summary of the overall results and findings, as well as the lessons learned during the course of the Project.

  8. Serological assessment of gastric mucosal atrophy in gastric cancer

    Directory of Open Access Journals (Sweden)

    Bornschein Jan

    2012-01-01

    Full Text Available Abstract Background Non-invasive tools for gastric cancer screening and diagnosis are lacking. Serological testing with the detection of pepsinogen 1 (PG1, pepsinogen 2 (PG2 and gastrin 17 (G17 offers the possibility to detect preneoplastic gastric mucosal conditions. Aim of this study was to assess the performance of these serological tests in the presence of gastric neoplasia. Methods Histological and serological samples of 118 patients with gastric cancer have been assessed for tumor specific characteristics (Laurén type, localisation, degree of mucosal abnormalities (intestinal metaplasia, atrophy and serological parameters (PG1, PG2, PG1/2-ratio, G17, H. pylori IgG, CagA status. Association of the general factors to the different serological values have been statistically analyzed. Results Patients with intestinal type gastric cancer had lower PG1 levels and a lower PG1/2-ratio compared to those with diffuse type cancer (p = 0.003. The serum levels of PG2 itself and G17 were not significantly altered. H. pylori infection in general had no influence on the levels of PG1, PG2 and G17 in the serum of gastric cancer patients. There was a trend towards lower PG1 levels in case of positive CagA-status (p = 0.058. The degree of both intestinal metaplasia and atrophy correlated inversely with serum levels for PG1 and the PG1/2-ratio (p Conclusions Glandular atrophy and a positive CagA status are determinant factors for decreased pepsinogen 1 levels in the serum of patients with gastric cancer. The serological assessment of gastric atrophy by analysis of serum pepsinogen is only adequate for patients with intestinal type cancer.

  9. Condition Assessment Technologies for Water Transmission and Distribution Systems

    Science.gov (United States)

    As part of the U.S. Environmental Protection Agency’s (EPA’s) Aging Water Infrastructure Research Program, this research was conducted to identify and characterize the state of the technology for structural condition assessment of drinking water transmission and distribution syst...

  10. Nutrition and health technology assessment: When two worlds meet

    NARCIS (Netherlands)

    M.J. Poley (Marten)

    2015-01-01

    textabstractThere is a growing recognition that nutrition may have a positive impact on public health and that it may reduce medical expenditures. Yet, such claims need to be substantiated by evidence. This evidence could be delivered by health technology assessment (HTA), which can be thought of as

  11. Reimbursement of pharmaceuticals: Reference pricing versus health technology assessment

    NARCIS (Netherlands)

    M. Drummond (Michael); B. Jönsson (Bengt); F.F.H. Rutten (Frans); T. Stargardt (Tom)

    2011-01-01

    textabstractReference pricing and health technology assessment are policies commonly applied in order to obtain more value for money from pharmaceuticals. This study focussed on decisions about the initial price and reimbursement status of innovative drugs and discussed the consequences for market a

  12. Integrating ethics in health technology assessment: many ways to Rome

    NARCIS (Netherlands)

    Hofmann, B.; Oortwijn, W.; Lysdahl, K. Bakke; Refolo, P.; Sacchini, D.; Wilt, G.J. van der; Gerhardus, A.

    2015-01-01

    OBJECTIVES: The aim of this study was to identify and discuss appropriate approaches to integrate ethical inquiry in health technology assessment (HTA). METHODS: The key question is how ethics can be integrated in HTA. This is addressed in two steps: by investigating what it means to integrate ethic

  13. Mapping of health technology assessment in selected countries

    NARCIS (Netherlands)

    Oortwijn, W.; Broos, P.; Vondeling, H.; Banta, D.; Todorova, L.

    2013-01-01

    Objectives: The aim of this study was to develop and apply an instrument to map the level of health technology assessment (HTA) development at country level in selected countries. We examined middle-income countries (Argentina, Brazil, India, Indonesia, Malaysia, Mexico, and Russia) and countries we

  14. Teknologvurdering, Broer og Brugere (Technology Assessment: Bridges and Users)

    DEFF Research Database (Denmark)

    Munch, Birgitte

    A critique of the scientific approaches grounding Danish technology assessments for beingnon-reflexive upon the consequences of its biased treatment of who and how some countsas ‘users'. Implications and new approaches are outlined in a story of engineering designers conceptualization of ships...

  15. Framework for dementia Quality of Life assessment with Assistive Technology

    DEFF Research Database (Denmark)

    Peterson, Carrie Beth; Prasad, Neeli R.; Prasad, Ramjee

    2010-01-01

    This paper proposes a theoretical framework for a Quality of Life (QOL) evaluation tool that is sensitive, flexible, computerized, and specific to assistive technology (AT) for dementia care. Using the appropriate evaluation tool serves to improve methodologies that are used for AT assessment...

  16. Computer-aided Detection of Prostate Cancer with MRI: Technology and Applications.

    Science.gov (United States)

    Liu, Lizhi; Tian, Zhiqiang; Zhang, Zhenfeng; Fei, Baowei

    2016-08-01

    One in six men will develop prostate cancer in his lifetime. Early detection and accurate diagnosis of the disease can improve cancer survival and reduce treatment costs. Recently, imaging of prostate cancer has greatly advanced since the introduction of multiparametric magnetic resonance imaging (mp-MRI). Mp-MRI consists of T2-weighted sequences combined with functional sequences including dynamic contrast-enhanced MRI, diffusion-weighted MRI, and magnetic resonance spectroscopy imaging. Because of the big data and variations in imaging sequences, detection can be affected by multiple factors such as observer variability and visibility and complexity of the lesions. To improve quantitative assessment of the disease, various computer-aided detection systems have been designed to help radiologists in their clinical practice. This review paper presents an overview of literatures on computer-aided detection of prostate cancer with mp-MRI, which include the technology and its applications. The aim of the survey is threefold: an introduction for those new to the field, an overview for those working in the field, and a reference for those searching for literature on a specific application.

  17. Technologic developments in the field of photonics for the detection of urinary bladder cancer.

    Science.gov (United States)

    Palmer, Scott; Sokolovski, Sergei G; Rafailov, Edik; Nabi, Ghulam

    2013-12-01

    Bladder cancer is a common cause of morbidity and mortality worldwide in an aging population. Each year, thousands of people, mostly men, are diagnosed with this disease, but many of them present too late to receive optimal treatment. As with all cancers, early diagnosis of bladder cancer significantly improves the efficacy of therapy and increases survival and recurrence-free survival rates. Ongoing research has identified many limitations about the sensitivity of standard diagnostic procedures in detecting early-stage tumors and precancerous changes. The consequences of this are often tumor progression and increased tumor burden, leading to a decrease in patient quality of life and a vast increase in treatment costs. The necessity for improved early detection of bladder cancer has spurred on research into novel methods that use a wide range of biological and photonic phenomena. This review will broadly discuss standard detection methodologies and their major limitations before covering novel photonic techniques for early tumor detection and staging, assessing their diagnostic accuracy for flat and precancerous changes. We will do so in the context of both cystoscopic examination and the screening of voided urine and will also touch on the concept of using photonic technology as a surgical tool for tumor ablation.

  18. A Ten-Year Assessment of a Biomedical Engineering Summer Research Internship within a Comprehensive Cancer Center

    Science.gov (United States)

    Wright, A. S.; Wu, X.; Frye, C. A.; Mathur, A. B.; Patrick, C. W., Jr.

    2007-01-01

    A Biomedical Engineering Internship Program conducted within a Comprehensive Cancer Center over a 10 year period was assessed and evaluated. Although this is a non-traditional location for an internship, it is an ideal site for a multidisciplinary training program for science, technology, engineering, and mathematics (STEM) students. We made a…

  19. [Social medicine assessment of patients with prostate cancer].

    Science.gov (United States)

    Hoffmann, W; Vahlensieck, W; Zermann, D-H

    2016-11-01

    Due to the increasing incidence of prostate cancer in social-medicine-relevant age groups, a correct subject-specific evaluation of the professional capacity of these patients with all stages of disease is required. A concluding assessment is only significant when based on concrete functional deficits.

  20. Assessing the Quality, Feasibility, and Efficacy of Electronic Patient Platforms Designed to Support Adolescents and Young Adults With Cancer: A Systematic Review Protocol

    Science.gov (United States)

    McCann, Lisa

    2017-01-01

    Background A range of innovative websites, mobile technologies, eHealth and mHealth platforms have emerged to support adolescents and young adults (AYAs) with cancer. Previous reviews have identified these various applications and solutions, but no review has summarized the quality, feasibility, and efficacy of existing patient platforms (inclusive of websites, mobile technologies, mHealth and eHealth platforms) developed specifically for young people with cancer. Objective This paper describes the design of a protocol to conduct a review of published studies or reports which describe or report on an existing platform designed specifically for AYAs who have had a cancer diagnosis. Methods A search string was developed using a variety of key words and Medical Subject Heading and applied to bibliographic databases. General data (sample characteristics, patient platform development, design and, if applicable, pilot testing outcomes) will be extracted from reports and studies. Drawing on a previously developed coding schematic, the identified patient platforms will be coded for mode of delivery into (1) automated functions, (2) communicative functions, and (3) use of supplementary modes. An adapted version of the Mobile App Rating Scale (MARS) will be used to assess the of quality of each identified patient platform. The methodological quality of included studies will be assessed using the Quality Assessment Criteria for Evaluating Primary Research Papers from a Variety of Fields (QualSyst). Both authors will independently screen eligible studies for final inclusion and will both be responsible for data extraction and appraisal. Data will be synthesized narratively to provide an overview of identified patient platforms. Results The review began in October 2016 and is currently in progress. The review paper will be submitted for peer-review and publication in the summer of 2017. Conclusions This review will be unique in its focus on assessing, where possible, the

  1. Assessing nano cellulose developments using science and technology indicators

    Energy Technology Data Exchange (ETDEWEB)

    Milanez, Douglas Henrique; Amaral, Roniberto Morato do; Faria, Leandro Innocentini Lopes de; Gregolin, Jose Angelo Rodrigues, E-mail: douglasmilanez@yahoo.com.br [Universidade Federal de Sao Carlos (UFSCar), SP (Brazil). Nucleo de Informacao Tecnologica em Materiais. Dept. de Engenharia de Materiais

    2013-11-01

    This research aims to examine scientific and technological trends of developments in nano cellulose based on scientometric and patent indicators obtained from the Science Citation Index and Derwent Innovations Index in 2001-2010. The overall nano cellulose activity indicators were compared to nanotechnology and other selected nano materials. Scientific and technological future developments in nano cellulose were forecasted using extrapolation growth curves and the main countries were also mapped. The results showed that nano cellulose publications and patent documents have increased rapidly over the last five years with an average growth rate higher than that of nanotechnology and fullerene. The USA, Japan, France, Sweden and Finland all played a significant role in nano cellulose development and the extrapolation growth curves suggested that nano cellulose scientific and technological activities are still emerging. Finally, the evidence from this study recommends monitoring nano cellulose S and T advances in the coming years. (author)

  2. Assessing nanocellulose developments using science and technology indicators

    Directory of Open Access Journals (Sweden)

    Douglas Henrique Milanez

    2013-06-01

    Full Text Available This research aims to examine scientific and technological trends of developments in nanocellulose based on scientometric and patent indicators obtained from the Science Citation Index and Derwent Innovations Index in 2001-2010. The overall nanocellulose activity indicators were compared to nanotechnology and other selected nanomaterials. Scientific and technological future developments in nanocellulose were forecasted using extrapolation growth curves and the main countries were also mapped. The results showed that nanocellulose publications and patent documents have increased rapidly over the last five years with an average growth rate higher than that of nanotechnology and fullerene. The USA, Japan, France, Sweden and Finland all played a significant role in nanocellulose development and the extrapolation growth curves suggested that nanocellulose scientific and technological activities are still emerging. Finally, the evidence from this study recommends monitoring nanocellulose S&T advances in the coming years.

  3. A model for technology assessment and commercialization for innovative disruptive technologies

    Energy Technology Data Exchange (ETDEWEB)

    KASSICIEH, SULEIMAN K.; WALSH, STEVE; MCWHORTER,PAUL J.; CUMMINGS JR.,JOHN C.; WILLIAMS,W. DAVID; ROMIG JR.,ALTON D.

    2000-05-17

    Disruptive technologies are scientific discoveries that break through the usual product technology capabilities and provide a basis for a new competitive paradigm as described by Anderson and Tushman [1990], Tushman and Rosenkopf [1992], and Bower and Christensen [1995]. Discontinuous innovations are products/processes/services that provide exponential improvements in the value received by the customer much in the same vein as Walsh [1996], Lynn, Morone and Paulson [1996], and Veryzer [1998]. For more on definitions of disruptive technologies and discontinuous innovations, see Walsh and Linton [1999] who provide a number of definitions for disruptive technologies and discontinuous innovations. Disruptive technologies and discontinuous innovations present a unique challenge and opportunity for R and D organizations seeking to build their commercialization efforts and to reinvent the corporation. These technologies do not have a proven path from scientific discovery to mass production and therefore require novel approaches. These critically important technologies are the wellspring of wealth creation and new competency generation but are not readily accepted by the corporate community. They are alternatively embraced and eschewed by the commercial community. They are finally accepted when the technology has already affected the industry or when the technological horse has already flown out of the hanger. Many firms, especially larger firms, seem reluctant to familiarize themselves with these technologies quickly. The trend seems to be that these firms prefer to react to a proven disruptive technology that has changed the product market paradigm. If true, then there is cause for concern. This paper will review the literature on disruptive technologies presenting a model of the progression from scientific idea to mass production for disruptive technologies contrasted to the more copious incremental technologies. The paper will then describe Sandia National Laboratories

  4. Human factors assessments of innovative technologies: Robotics sector

    Energy Technology Data Exchange (ETDEWEB)

    Moran, J.B. [Operating Engineers National Hazmat Program, Beaver, WV (United States)

    1997-12-01

    The U.S. Department of Energy (DOE) has funded major environmental technology developments over the past several years. One area that received significant attention is robotics, which has resulted in the development of a wide range of unique robotic systems tailored to the many tasks unique to the DOE complex. These systems are often used in highly hazardous environments, which reduces or eliminates worker exposures. The DOE, concurrent with the technology development initiative, also established and funded a 5-yr cooperative agreement intended to interface with the technology development community-with specific attention to the occupational safety and health aspects associated with individual technologies through human factors and hazard assessments. This program is now in its third year.

  5. ALINET: a model for assessing energy conservation opportunities in the food processing industry. Final technical report, September 1977-December 1979

    Energy Technology Data Exchange (ETDEWEB)

    Levis, A H; Ducot, E R; Levis, I S; Webster, T F

    1979-12-01

    ALINET is a network model designed for the analysis of energy use in the food processing and distribution sector and for the evaluation of the potential effectiveness of energy conserving technologies. The conceptual framework of the model, as well as the design and implementation of the computer software are described. The wheat system at the national, state, and facility-specific level is used to illustrate the model's operation and use. A pilot project, carried out in cooperation with industry, is described in which energy use in (a) hard wheat milling, and (b) durum milling and pasta manufacture is analyzed. Finally, the introduction of an alternative technology for pasta drying is assessed in terms of energy conservation and cost. Recommendation for further applications and institutionalization of the model are made.

  6. Esophageal Cancer: Role of Imaging in Primary Staging and Response Assessment Post Neoadjuvant Therapy.

    Science.gov (United States)

    Griffin, Yvette

    2016-08-01

    Advances in the early detection and treatment of esophageal cancer have meant improved survival rates for patients with esophageal cancer. Accurate pretreatment and post-neoadjuvant treatment staging of esophageal cancer is essential for assessing operability and determining the optimum treatment plan. This article reviews the multimodality imaging approach in the diagnosis, staging, and assessment of treatment response in esophageal cancer.

  7. Using Technology to Improve Cancer Care: Social Media, Wearables, and Electronic Health Records.

    Science.gov (United States)

    Fisch, Michael J; Chung, Arlene E; Accordino, Melissa K

    2016-01-01

    Digital engagement has become pervasive in the delivery of cancer care. Internet- and cellular phone-based tools and systems are allowing large groups of people to engage with each other and share information. Health systems and individual health professionals are adapting to this revolution in consumer and patient behavior by developing ways to incorporate the benefits of technology for the purpose of improving the quality of medical care. One example is the use of social media platforms by oncologists to foster interaction with each other and to participate with the lay public in dialogue about science, medicine, and cancer care. In addition, consumer devices and sensors (wearables) have provided a new, growing dimension of digital engagement and another layer of patient-generated health data to foster better care and research. Finally, electronic health records have become the new standard for oncology care delivery, bringing new opportunities to measure quality in real time and follow practice patterns, as well as new challenges as providers and patients seek ways to integrate this technology along with other forms of digital engagement to produce more satisfaction in the process of care along with measurably better outcomes.

  8. Content validity across methods of malnutrition assessment in patients with cancer is limited

    NARCIS (Netherlands)

    Sealy, Martine J.; Nijholt, Willemke; Stuiver, Martijn M.; van der Berg, Marit M.; Roodenburg, Jan L. N.; Schans, van der Cees P.; Ottery, Faith D.; Jager-Wittenaar, Harriet

    2016-01-01

    Objective: To identify malnutrition assessment methods in cancer patients and assess their content validity based on internationally accepted definitions for malnutrition. Study Design and Setting: Systematic review of studies in cancer patients that operationalized malnutrition as a variable, publi

  9. Management support services to the Office of Utility Technologies. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-16

    The Office of Utility Technologies works cooperatively with industry and the utility sector to realize the market potential for energy efficiency and renewable energy technologies. Under this contract, BNF has provided management support services for OUT R&D activities for the following Program offices: (1) Office of Energy Management; (2) Office of Solar Energy Conversion; (3) Office of Renewable Energy Conversion; and (4) Deputy Assistant Secretary. During the period between 4/17/91 and 9/17/93, BNF furnished the necessary personnel, equipment, materials, facilities and travel required to provide management support services for each of the above Program Offices. From 9/18/93 to 12/17/93, BNF has been involved in closeout activities, including final product deliverables. Research efforts that have been supported in these Program Offices are: (1) for Energy Management -- Advanced Utility Concepts Division; Utility Systems Division; Integrated Planning; (2) for Solar Energy Conversion -- Photovoltaics Division; Solar Thermal and Biomass Power Division; (3) for Renewable Energy Conversion -- Geothermal Division; Wind, Hydroelectric and Ocean Systems Division; (4) for the Deputy Assistant Secretary -- support as required by the Supporting Staff. This final report contains summaries of the work accomplished for each of the Program Offices listed above.

  10. Moving Forward in Human Cancer Risk Assessment

    OpenAIRE

    Paules, Richard S.; Aubrecht, Jiri; Corvi, Raffaella; Garthoff, Bernward; Kleinjans, Jos C.

    2010-01-01

    Background The current safety paradigm for assessing carcinogenic properties of drugs, cosmetics, industrial chemicals, and environmental exposures relies mainly on in vitro genotoxicity testing followed by 2-year rodent bioassays. This testing battery is extremely sensitive but has low specificity. Furthermore, rodent bioassays are associated with high costs, high animal burden, and limited predictive value for human risks. Objectives We provide a response to a growing appeal for a paradigm ...

  11. DECISION ANALYSIS AND TECHNOLOGY ASSESSMENTS FOR METAL AND MASONRY DECONTAMINATION TECHNOLOGIES

    Energy Technology Data Exchange (ETDEWEB)

    M.A. Ebadian, Ph.D.

    1999-01-01

    The purpose of this investigation was to conduct a comparative analysis of innovative technologies for the non-aggressive removal of coatings from metal and masonry surfaces and the aggressive removal of one-quarter to one-inch thickness of surface from structural masonry. The technologies tested should be capable of being used in nuclear facilities. Innovative decontamination technologies are being evaluated under standard, non-nuclear conditions at the FIU-HCET technology assessment site in Miami, Florida. This study is being performed to support the OST, the Deactivation and Decommissioning (D&D) Focus Area, and the environmental restoration of DOE facilities throughout the DOE complex by providing objective evaluations of currently available decontamination technologies.

  12. DOE SciDAC's Earth System Grid Center for Enabling Technologies Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Dean N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2011-09-27

    Computing Centre, the National Aeronautics and Space Administration Jet Propulsion Laboratory, and the National Oceanic and Atmospheric Administration. The ESGF software is distinguished from other collaborative knowledge systems in the climate community by its widespread adoption, federation capabilities, and broad developer base. It is the leading source for present climate data holdings, including the most important and largest data sets in the global-climate community, and - assuming its development continues - we expect it to be the leading source for future climate data holdings as well. Recently, ESG-CET extended its services beyond data-file access and delivery to include more detailed information products (scientific graphics, animations, etc.), secure binary data-access services (based upon the OPeNDAP protocol), and server-side analysis. The latter capabilities allow users to request data subsets transformed through commonly used analysis and intercomparison procedures. As we transition from development activities to production and operations, the ESG-CET team is tasked with making data available to all users seeking to understand, process, extract value from, visualize, and/or communicate it to others. This ongoing effort, though daunting in scope and complexity, will greatly magnify the value of numerical climate model outputs and climate observations for future national and international climate-assessment reports. The ESG-CET team also faces substantial technical challenges due to the rapidly increasing scale of climate simulation and observational data, which will grow, for example, from less than 50 terabytes for the last Intergovernmental Panel on Climate Change (IPCC) assessment to multiple Petabytes for the next IPCC assessment. In a world of exponential technological change and rapidly growing sophistication in climate data analysis, an infrastructure such as ESGF must constantly evolve if it is to remain relevant and useful. Regretfully, we submit our

  13. The Clinician's Toolbox: Assessing the Sexual Impacts of Cancer on Adolescents and Young Adults with Cancer (AYAC

    Directory of Open Access Journals (Sweden)

    Sylvie Aubin, PhD

    2015-09-01

    Conclusion: Cancer can have a significant impact on numerous domains of AYAC sexuality. The assessment of and attention to the impact of sexuality on AYAC is crucial in order to provide effective and comprehensive quality patient cancer care. Aubin S and Perez S. The clinician's toolbox: assessing the sexual impacts of cancer on adolescents and young adults with cancer (AYAC. Sex Med 2015;3:198–212.

  14. Recent Life Assessment Technology for Existing Steam Turbines

    Science.gov (United States)

    Saito, Kiyoshi; Sakuma, Akira; Fukuda, Masataka

    A large and growing portion of electricity is produced by aging thermal power plants. Although excellent, high quality materials such as CrMoV steel and 12% Cr steel, etc. are used for the steam turbines, various forms of metallurgical degradation, due to creep and fatigue, etc. affect the parts and components during long-term operation at high temperature. Extending the life of steam turbines and ensuring high reliability requires life assessment technology, scheduled repairing, conversion, modification and upgrading of components in order to provide a stable power supply. As the high temperature parts and components of aged steam turbines are mainly metallurgically damaged by creep, fatigue and the interaction of both, life assessment combined with analytical and nondestructive methods is essential for realizing strategic plant life extension. We have developed a life assessment technology that takes material degradation into consideration, and have applied the procedure to more than 650 units and 2500 components since 1983. A rotor bore replication device was developed in 1989 for the purpose of nondestructive observation of creep voids and supporting the validity of life prediction results. This paper describes the technical features and applied experience of recent life assessment technology for existing high temperature steam turbines.

  15. The study of the life cycle of technology assessment model

    Institute of Scientific and Technical Information of China (English)

    SHEN Yu-Zhi; HUANG Xun-jiang

    2001-01-01

    The life cycle of technology is one of the most important indexes to weigh up the risk of the investment to neo-tech. There are so many uncertainties because it is conditioned by a lot of factors, we can not make a rational forecasting by traditional assessment method. So this paper gives a conprehensive consideration to the factors that influence production and makes some modification to production function, and establishes the life cycle of technology assessmet model by the method of fuzzy mathematics. So it quantifies the risk of investment. We can take it as one foundational index for the decision making of the investment.

  16. Technological and life cycle assessment of organics processing odour control technologies.

    Science.gov (United States)

    Bindra, Navin; Dubey, Brajesh; Dutta, Animesh

    2015-09-15

    As more municipalities and communities across developed world look towards implementing organic waste management programmes or upgrading existing ones, composting facilities are emerging as a popular choice. However, odour from these facilities continues to be one of the most important concerns in terms of cost & effective mitigation. This paper provides a technological and life cycle assessment of some of the different odour control technologies and treatment methods that can be implemented in organics processing facilities. The technological assessment compared biofilters, packed tower wet scrubbers, fine mist wet scrubbers, activated carbon adsorption, thermal oxidization, oxidization chemicals and masking agents. The technologies/treatment methods were evaluated and compared based on a variety of operational, usage and cost parameters. Based on the technological assessment it was found that, biofilters and packed bed wet scrubbers are the most applicable odour control technologies for use in organics processing faculties. A life cycle assessment was then done to compare the environmental impacts of the packed-bed wet scrubber system, organic (wood-chip media) bio-filter and inorganic (synthetic media) bio-filter systems. Twelve impact categories were assessed; cumulative energy demand (CED), climate change, human toxicity, photochemical oxidant formation, metal depletion, fossil depletion, terrestrial acidification, freshwater eutrophication, marine eutrophication, terrestrial eco-toxicity, freshwater eco-toxicity and marine eco-toxicity. The results showed that for all impact categories the synthetic media biofilter had the highest environmental impact, followed by the wood chip media bio-filter system. The packed-bed system had the lowest environmental impact for all categories.

  17. ADVANTAGES AND APPLICATIONS OF TISSUE MICROARRAY TECHNOLOGY ON CANCER RESEARCH

    Institute of Scientific and Technical Information of China (English)

    张喜平; 苏丹; 程琪辉

    2003-01-01

    S To provide evidences for exploiting tissue microarray (TMA) technology, we reviewed advantages and applications of TMA on tumor research. TMA has many advantages, including (1) section from TMA blocks can be utilized for the simultaneous analysis of up to 1,000 different tumors at DNA, RNA or protein level; (2) TMA is highly representative of their donor tissues; (3) TMA can improve conservation of tissue resources and experimental reagents, improve internal experimental control, and increase sample numbers per experiment, and can be used for large-scale, massively parallel in situ analysis; (4) TMA facilitates rapid translation of molecular discoveries to clinical applications. TMA has been applied to tumor research, such as glioma, breast tumor, lung cancer and so on. The development of novel biochip technologies has opened up new possibilities for the high-throughput molecular profiling of human tumors. Novel molecular markers emerging from high-throughput expression surveys could be analyzed on tumor TMA. It is anticipated that TMA, a new member of biochip, will soon become a widely used tool for all types of tissue-based research. TMA will lead to a significant acceleration of the transition of basic research findings into clinical applications.

  18. Hanford Tank Farm Vapors Abatement Technology and Vendor Proposals Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Burns, H. H. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Farrar, M. E. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Fink, S. D. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2016-09-20

    Suspected chemical vapor releases from the Hanford nuclear waste tank system pose concerns for worker exposure. Washington River Protection Solutions (WRPS) contracted the Savannah River National Laboratory (SRNL) to explore abatement technologies and strategies to remediate the vapors emitted through the ventilation system. In response, SRNL conducted an evaluation of technologies to abate, or reduce, vapor emissions to below 10% of the recognized occupational exposure limits (OELs). The evaluation included a review of published literature and a broadly communicated Request for Information to commercial vendors through a Federal Business Opportunities (Fed Biz Opps) web posting. In addition, SRNL conducted a workshop and post-workshop conference calls with interested suppliers (vendors) to assess proposals of relevant technologies. This report reviews applicable technologies and summarizes the approaches proposed by the vendors who participated in the workshop and teleconference interviews. In addition, the report evaluates the estimated performance of the individual technologies for the various classes of chemical compounds present in the Hanford Chemicals of Potential Concern (COPCs) list. Similarly, the report provides a relative evaluation of the vendor proposed approaches against criteria of: technical feasibility (and maturity), design features, operational considerations, secondary waste generation, safety/regulatory, and cost / schedule. These rough order-of-magnitude (ROM) cost estimates are intended to provide a comparison basis between technologies and are not intended to be actual project estimates.

  19. Hanford Tank Farm Vapors Abatement Technology and Vendor Proposals Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Burns, H. H. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Farrar, M. E. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Fink, S. D. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2016-09-20

    Suspected chemical vapor releases from the Hanford nuclear waste tank system pose concerns for worker exposure. Washington River Protection Solutions (WRPS) contracted the Savannah River National Laboratory (SRNL) to explore abatement technologies and strategies to remediate the vapors emitted through the ventilation system. In response, SRNL conducted an evaluation of technologies to abate, or reduce, vapor emissions to below 10% of the recognized occupational exposure limits (OELs). The evaluation included a review of published literature and a broadly communicated Request for Information to commercial vendors through a Federal Business Opportunities (Fed Biz Opps) web posting. In addition, SRNL conducted a workshop and post-workshop conference calls with interested suppliers (vendors) to assess proposals of relevant technologies. This report reviews applicable technologies and summarizes the approaches proposed by the vendors who participated in the workshop and teleconference interviews. In addition, the report evaluates the estimated performance of the individual technologies for the various classes of chemical compounds present in the Hanford Chemicals of Potential Concern (COPCs) list. Similarly, the report provides a relative evaluation of the vendor proposed approaches against criteria of: technical feasibility (and maturity), design features, operational considerations, secondary waste generation, safety/regulatory, and cost / schedule. These rough order magnitude (ROM) cost estimates are intended to provide a comparison basis between technologies and are not intended to be actual project estimates.

  20. ECASTAR: Energy Conservation; an Assessment of Systems, Technologies and Requirements

    Science.gov (United States)

    1975-01-01

    A methodology for a systems approach display and assessment of the potential for energy conservation actions and the impacts of those actions was presented. The U.S. economy is divided into four sectors: energy industry, industry, residential/commercial and transportation. Each sector is assessed with respect to energy conservation actions and impacts. The four sectors are combined and three strategies for energy conservation actions for the combined sectors are assessed. The three strategies (national energy conservation, electrification and diversification) represent energy conservation actions for the near term (now to 1985), the mid term (1985 to 2000) and the far term (2000 and beyond). The assessment procedure includes input/output analysis to bridge the flows between the sectors, and net economics and net energetics as performance criteria for the conservation actions. Targets of opportunity for large net energy net energy savings and the application of technology to achieve these savings are discussed.

  1. Sailor: Maryland's Online Public Information Network. Sailor Network Assessment Final Report Compendium.

    Science.gov (United States)

    Bertot, John Carlo; McClure, Charles R.

    This compendium is a companion document to the Maryland Sailor Online Public Information Network assessment final report, and contains detailed study findings, study data collection activity write-ups, detailed methodologies, data collection tools, and consultant notes on the uses of the study's data collection instruments. The purpose of the…

  2. Identification and assessment of site treatment plan implementation opportunities for emerging technologies

    Energy Technology Data Exchange (ETDEWEB)

    Bernard, E.A. [Sandia National Labs., Germantown, MD (United States)

    1995-12-31

    The Department of Energy (DOE), in response to the 1992 Federal Facility Compliance Act, has prepared Site Treatment Plans (STP) for the approximately 2,000 waste streams identified within its mixed waste inventory Concurrently, emerging mixed waste treatment technologies are in final development. This paper defines a three-phase process to identify and assess implementation opportunities for these emerging technologies within the STP. It highlights the first phase, functional matching of expected treatment capabilities with proposed treatment requirements. Matches are based on treatment type, regulated contaminant and waste matrix type, for both capabilities and requirements. Results identify specific waste streams and volumes that could be treated by each emerging technology. A study for Plasma Hearth Process, Delphi DETOX{sup sm}, Supercritical Water Oxidation and Vitrification shows that about 200,000 ml of DOE`s mixed waste inventory can potentially be treated by one or more of these emerging technologies. Actual implementations are small fractions of the treatable inventory. Differences between potential and actual implementations must be minimized to accrue optimum benefit from implementation of emerging or alternative treatment technologies. Functional matching is the first phase in identifying and quantifying benefits, addressing technology system and treatment issues, and providing, in part, the basis for STP implementation decisions. DOE, through EM`s Office of Technology Development, has funded this work.

  3. An abuse of risk assessment: how regulatory agencies improperly adopted LNT for cancer risk assessment.

    Science.gov (United States)

    Calabrese, Edward J

    2015-04-01

    The Genetics Panel of the National Academy of Sciences' Committee on Biological Effects of Atomic Radiation (BEAR) recommended the adoption of the linear dose-response model in 1956, abandoning the threshold dose-response for genetic risk assessments. This recommendation was quickly generalized to include somatic cells for cancer risk assessment and later was instrumental in the adoption of linearity for carcinogen risk assessment by the Environmental Protection Agency. The Genetics Panel failed to provide any scientific assessment to support this recommendation and refused to do so when later challenged by other leading scientists. Thus, the linearity model used in cancer risk assessment was based on ideology rather than science and originated with the recommendation of the NAS BEAR Committee Genetics Panel. Historical documentation in support of these conclusions is provided in the transcripts of the Panel meetings and in previously unexamined correspondence among Panel members.

  4. Environmental assessment of solid waste systems and technologies: EASEWASTE

    DEFF Research Database (Denmark)

    Kirkeby, Janus Torsten; Birgisdottir, Harpa; Hansen, Trine Lund;

    2006-01-01

    A new model has been developed for evaluating the overall resource consumption and environmental impacts of municipal solid waste management systems by the use of life cycle assessment. The model is named EASEWASTE (Environmental Assessment of Solid Waste Systems and Technologies) and is able...... may not always be the most environmentally friendly. The EASEWASTE model can identify the most environmentally sustainable solution, which may differ among waste materials and regions and can add valuable information about environmental achievements from each process in a solid waste management system....... to compare different waste management strategies, waste treatment methods and waste process technologies. The potential environmental impacts can be traced back to the most important processes and waste fractions that contribute to the relevant impacts. A model like EASEWASTE can be used by waste planners...

  5. Implementation of Relevant Methods in Assessing Traffic-Technological Projects

    Directory of Open Access Journals (Sweden)

    Danijela Barić

    2007-09-01

    Full Text Available The assessment of investment traffic-technological projectsmeans a set of activities whose basic aim is to determine the justificationand feasibility of the projects. The decision-makingprocess, including the decision-making on investments is an extremelycomplex process, and the decision-maker has to have avision of the future and make decisions accordingly in a modemand flexible manner. Therefore, the decisions need to be theresult of a planning and research process based on relevant scientificmethods. The work includes the selected, analysed andpresented methods of cost-benefit analysis, methods of multi-criteria decision-making and SWOT (Strengths, Weaknesses,Opportunities, and Threats analysis methods. Regarding thebasic characteristics, the mentioned methods have been compared,the order of their implementation has been determined,and then they have been implemented in assessing the traffic-technological projects of reconstmction with the aim of selectingthe optimal variant solution.

  6. Technical and economic assessment of energy conversion technologies for MSW

    Energy Technology Data Exchange (ETDEWEB)

    Livingston, W.R.

    2002-07-01

    Thermal processes for municipal solid wastes (MSW) based on pyrolysis and/or gasification that have relevance to the emerging UK market are described in this report, and the results of the technical and economical assessment of these processes are presented. The Mitsui R21 Technology, the Thermoselect Process, the Nippon Steel Waste Melting Process, the Pyropleq Process, and the Compact Power Process are selected for detailed comparison on the basis of the overall technical concept, the energy balance and the requirements for consumables, environmental performance, and the technical and commercial status of the technology. Details are also given of a comparison of the novel thermal technologies with conventional mass burn incineration for MSW.

  7. Teacher Learning of Technology-Enhanced Formative Assessment

    CERN Document Server

    Beatty, Ian D; Leonard, William J; Gerace, William J; Cyr, Karen St; Lee, Hyunju; Harris, Robby

    2008-01-01

    Technology-Enhanced Formative Assessment (TEFA) is a pedagogy for teaching with classroom response technology. Teacher Learning of TEFA is a five-year research project studying teacher change, in the context of an intensive professional development program designed to help science and mathematics teachers learn TEFA. First, we provide an overview of the project's participating teachers, its intervention (consisting of the technology, the pedagogy, and the professional development program), and its research design. Then, we present narratives describing the unfolding change process experienced by four teachers. Afterward, we present some preliminary findings of the research, describe a "model for the co-evolution of teacher and pedagogy" that we are developing, and identify general implications for professional development.

  8. Proposal for a state health technology assessment program.

    Science.gov (United States)

    Colmenares, Phil

    2012-08-01

    Evidence suggests that a significant number of medical technologies are of little or no benefit to patients. Under current budgetary pressures, state health care programs cannot afford continued spending on unnecessary medical care without further cuts in enrollment. Limiting coverage of high-tech care only to indications supported by good clinical evidence would help save state health care dollars. However, there is currently no public process to formally evaluate new medical interventions in Wisconsin. In fact, new therapies often are introduced into clinical practice, and covered by state health insurance programs, even when there is weak or questionable evidence of clinical effectiveness. This article proposes the creation of a state Health Technology Assessment program in Wisconsin to systematically evaluate new tests or treatments, and to promote evidence-based coverage decisions. Such a program would help limit wasteful spending on unnecessary technologies, reinforce good clinical practice, and protect patients from the risks of interventions that have not been proven effective.

  9. An assessment of acid rock drainage continuous monitoring technology

    Science.gov (United States)

    Fytas, K.; Hadjigeorgiou, J.

    1995-02-01

    In order to assess the magnitude and impact at affected mine sites of acid rock drainage (ARD), fixed-frequency sampling is often employed. This often involves manual sampling, at regular time intervals, of water and solids. It is felt that such sampling does not adequately describe the system evolution. Continuous monitoring offers a viable alternative in that it can better follow the seasonal fluctuations and high-frequency variations that characterize ARD. This paper evaluates existing continuous monitoring technology.

  10. Preliminary technology utilization assessment of the robotic fruit harvester

    Science.gov (United States)

    Wilhelm, J.

    1982-01-01

    The results of an analysis whose purpose was to examine the history and progress of mechanical fruit harvesting, to determine the significance of a robotic fruit tree harvester and to assess the available market for such a product are summarized. Background information that can be used in determining the benefit of a proof of principle demonstration is provided. Such a demonstration could be a major step toward the transfer of this NASA technology.

  11. Assessment of quality of life in oral cancer.

    Science.gov (United States)

    Torres-Carranza, Eusebio; Infante-Cossío, Pedro; Hernández-Guisado, José María; Hens-Aumente, Elena; Gutierrez-Pérez, José Luis

    2008-11-01

    Quality of life (QL) in oral cancer patients has become one of the most important parameters to consider in the diagnosis and post-treatment follow-up. The purpose of this article has been to review the papers published that study the QL in oral cancer patients, the different QL questionnaires used, the clinical results obtained, and the systematic revisions available in the indexed literature for the last 10 years. The term QL appears as a keyword in an increasing number of articles throughout the past 10 years; however, few studies focus on oral cancer. Most of them assess all head and neck cancers, which conform to a heterogeneous group with several different features depending on location (oral cavity, oropharynx, larynx, hypopharynx, nasopharynx and salivary glands). Most studies evaluate QL in short periods of time, normally within the first year after the diagnosis. Series do not discern between different therapeutic options, and they generally center on Northern European or Northern American populations. There are few instruments translated and validated into Spanish that measure QL, a fundamental characteristic to link QL to own patients' socio-cultural parameters. Data related with QL are mostly related to patient (age, sex, co-morbidity), tumour (location, size), and treatment (surgical treatment, radiotherapy association, reconstruction, cervical dissection, and/or feeding tube). Nowadays QL's assessment is considered an essential component of an oral cancer patient as well as the survival, morbidity and years free of disease. Although many aspects related to QL in oral cancer patients have been published throughout the past 10 years, more systematic research is needed to be able to apply it on a daily basis.

  12. National Wind Technology Center sitewide, Golden, CO: Environmental assessment

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-01

    The National Renewable Energy Laboratory (NREL), the nation`s primary solar and renewable energy research laboratory, proposes to expand its wind technology research and development program activities at its National Wind Technology Center (NWTC) near Golden, Colorado. NWTC is an existing wind energy research facility operated by NREL for the US Department of Energy (DOE). Proposed activities include the construction and reuse of buildings and facilities, installation of up to 20 wind turbine test sites, improvements in infrastructure, and subsequent research activities, technology testing, and site operations. In addition to wind turbine test activities, NWTC may be used to support other NREL program activities and small-scale demonstration projects. This document assesses potential consequences to resources within the physical, biological, and human environment, including potential impacts to: air quality, geology and soils, water resources, biological resources, cultural and historic resources, socioeconomic resources, land use, visual resources, noise environment, hazardous materials and waste management, and health and safety conditions. Comment letters were received from several agencies in response to the scoping and predecisional draft reviews. The comments have been incorporated as appropriate into the document with full text of the letters contained in the Appendices. Additionally, information from the Rocky Flats Environmental Technology Site on going sitewide assessment of potential environmental impacts has been reviewed and discussed by representatives of both parties and incorporated into the document as appropriate.

  13. ICLIPS - integrated assessment of climate protection strategies. Final report; ICLIPS - Integrierte Abschaetzung von Klimaschutzstrategien. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Toth, F.L.; Bruckner, T.; Fuessel, H.M.

    2000-12-01

    The ICLIPs project is connected to the development of integrated climate impact research in Germany. It is concerned not only with a single dimension of possible impacts of climate change, but it also investigates these impacts in the context of adaptation options and mitigation possibilities. The Tolerable Windows Approach (TWA) permits the explicit consideration of both ecological and economic requirements in identifying tolerable climate protection strategies. This way it fulfills the central objective of science policy related to the complex issue of 'Sustainable Growth'. In the project period, the ICLIPS model, a detailed integrated model of global climate change ('Integrated Assessment Model', IAM) was developed in the framework of a successful international cooperation. As a result, climate impact research in Germany succeeded to catch up with the international forefront in a research field that is very important for practical policy advice, and even managed to take a leading role in some important sub-fields. The ICLIPS model contains a series of innovative features that clearly distinguish this model from other intertemporal optimization models. The features worth mentioning here include: a numerically highly efficient climate model that covers all relevant greenhouse gases; a series of Climate Impact Response Functions that depict climate-relevant changes in natural vegetation systems, agricultural yields, and water availability; and finally a model of long-term economic development that explicitly considers the cost-reducing effects of technological learning. (orig.) [German] Das ICLIPS-Projekt bezieht sich auf die Weiterentwicklung der integrierten Klimafolgenforschung in Deutschland, die sich nicht nur eindimensional mit moeglichen Auswirkungen von Klimaveraenderungen beschaeftigt, sondern diese zusammen mit Anpassungsoptionen und Vermeidungsmoeglichkeiten untersucht. Der Fensteransatz, der bei der Identifizierung von tolerierbaren

  14. Procedures for identifying reasonably available control technology for stationary sources of PM-10. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Fitzpatrick, M.J.; Ellefson, R.

    1992-09-01

    The guidance document sets forth procedures and identifies sources of information that will assist State and local air pollution control agencies in determining Reasonably Available Control Technology (RACT) for PM-10 (particulate matter having a nominal aerometric diameter of 10 microns or less) emission from existing stationary sources on a case-by-case basis. It provides an annotated bibliography of documents to aid in identifying the activities that cause PM-10 emissions as well as applicable air pollution control measures and their effectiveness in reducing emissions. The most stringent state total particulate matter (PM) emission limits are identified for several categories of PM-10 sources and compared to available emission test data. Finally, guidance is provided on procedures for estimating total capital investment and total annual cost of the control measures which are generally used to control PM-10 emissions.

  15. Prioritizing Information Technology Investments: Assessing the Correlations among Technological Readiness, Information Technology Flexibility, and Information Technology Effectiveness

    Science.gov (United States)

    Walter, John T.

    2010-01-01

    Management's dilemma, when allocating financial resources towards the improvement of technological readiness and IT flexibility within their organizations, is to control financial risk and maximize IT effectiveness. Technological readiness is people's propensity to embrace and use technology. Its drivers are optimism, innovativeness, discomfort,…

  16. Early breast cancer in the elderly: assessment and management considerations.

    Science.gov (United States)

    Albrand, Gilles; Terret, Catherine

    2008-01-01

    Breast cancer is a common tumour in the elderly and management of early disease in particular is a major challenge for oncologists and geriatricians alike. The process should begin with the Comprehensive Geriatric Assessment (CGA), which should be undertaken before any decisions about treatment are made. The important role of co-morbidities and their effect on life expectancy also need to be taken into account when making treatment decisions. The primary treatments for early breast cancer are surgery, adjuvant radiotherapy and adjuvant systemic therapy. Unfortunately, lack of a specific literature relating to early breast cancer in the elderly means formulating an evidence-based approach to treatment in this context is difficult. We have developed a new approach based on the CGA and comprehensive oncological assessment. This approach facilitates the development of an individualized oncogeriatric care plan and follow-up based on several considerations: the average patient's life expectancy at a given age; the patient's co-morbidities, level of dependence, and the impact of these considerations on diagnostic and therapeutic options as well as life expectancy; and the potential benefit-risk balance of treatment. In the elderly patient with breast cancer, the standard primary therapy is surgical resection (mastectomy or breast-conserving therapy). While node dissection is a major component of staging and local control of breast cancer, no data are available to guide decision-making in women aged >70 years. Primary endocrine therapy (tamoxifen) should be offered to elderly women with estrogen receptor (ER)-positive breast cancer only if they are unfit for or refuse surgery. Trials are needed to evaluate the clinical effectiveness of aromatase inhibitors as primary therapy for infirm older patients with ER-positive tumours. Breast irradiation should be recommended to older women with a life expectancy >5 years, particularly those with large tumours, positive lymph nodes

  17. U.S. Department of Energy FreedomCAR & Vehicle Technologies Program Oil Bypass Filter Technology Evaluation Final Report

    Energy Technology Data Exchange (ETDEWEB)

    L. R. Zirker; J. E. Francfort; J. J. Fielding

    2006-03-01

    This Oil Bypass Filter Technology Evaluation final report documents the feasibility of using oil bypass filters on 17 vehicles in the Idaho National Laboratory (INL) fleet during a 3-year test period. Almost 1.3 million test miles were accumulated, with eleven 4-cycle diesel engine buses accumulating 982,548 test miles and six gasoline-engine Chevrolet Tahoes accumulating 303,172 test miles. Two hundred and forty oil samples, taken at each 12,000-mile bus servicing event and at 3,000 miles for the Tahoes, documented the condition of the engine oils for continued service. Twenty-eight variables were normally tested, including the presence of desired additives and undesired wear metals such as iron and chrome, as well as soot, water, glycol, and fuel. Depending on the assumptions employed, the INL found that oil bypass filter systems for diesel engine buses have a positive payback between 72,000 and 144,000 miles. For the Tahoes, the positive payback was between 66,000 and 69,000 miles.

  18. Technology and economic assessment of lactic acid production and uses

    Energy Technology Data Exchange (ETDEWEB)

    Datta, R.; Tsai, S.P.

    1996-03-01

    Lactic acid has been an intermediate-volume specialty chemical (world production {approximately}50,000 tons/yr) used in a wide range of food-processing and industrial applications. Potentially, it can become a very large-volume, commodity-chemical intermediate produced from carbohydrates for feedstocks of biodegradable polymers, oxygenated chemicals, environmentally friendly ``green`` solvents, and other intermediates. In the past, efficient and economical technologies for the recovery and purification of lactic acid from fermentation broths and its conversion to the chemical or polymer intermediates had been the key technology impediments and main process cost centers. Development and deployment of novel separations technologies, such as electrodialysis with bipolar membranes, extractive and catalytic distillations, and chemical conversion, can enable low-cost production with continuous processes in large-scale operations. The emerging technologies can use environmentally sound lactic acid processes to produce environmentally useful products, with attractive process economics. These technology advances and recent product and process commercialization strategies are reviewed and assessed.

  19. Assessing effects of technology usage on mathematics learning

    Science.gov (United States)

    Lynch, Julianne

    2006-12-01

    Computer-based technologies are now commonplace in classrooms, and the integration of these media into the teaching and learning of mathematics is supported by government policy in most developed countries. However, many questions about the impact of computer-based technologies on classroom mathematics learning remain unanswered, and debates about when and how they ought to be used continue. An increasing number of studies seek to identify the effects of technology usage on classroom learning, and at a time when governments are calling for `evidence-based' policy development, many studies applying quasi-scientific methodologies to this field of practice are emerging. By analysing a series of conceptual frameworks for assessing the use of computer-based technologies to support school learning, this article emphasises the value of research into the relationship between technical and conceptual aspects of technology use in mathematics education and beyond, and challenges the usefulness of large-scale, quasi-scientific studies that focus on educational inputs and outputs.

  20. An assessment of desiccant cooling and dehumidification technology

    Energy Technology Data Exchange (ETDEWEB)

    Mei, V.C.; Chen, F.C. (Oak Ridge National Lab., TN (United States)); Lavan, Z. (Illinois Inst. of Tech., Chicago, IL (United States)); Collier, R.K. Jr. (Collier Engineering Services, Merritt Island, FL (United States)); Meckler, G. (Gershon Meckler Associates, P.C., Herndon, VA (United States))

    1992-07-01

    Desiccant systems are heat-actuated cooling and dehumidification technology. With the recent advances in this technology, desiccant systems can now achieve a primary energy coefficient of performance (COP) between 1.3 and 1.5, with potential to go to 1.7 and higher. It is becoming one of the most promising alternatives to conventional cooling systems. Two important and well-known advantages of desiccant cooling systems are that they are CFC free and they can reduce the electricity peak load. Another important but lesser-known advantage of desiccant technology is its potential for energy conservation. The energy impact study in this report indicated that a possible 13% energy saving in residential cooling and 8% in commercial cooling is possible. Great energy saving potential also exists in the industrial sector if industrial waste heat can be used for desiccant regeneration. The latest study on desiccant-integrated building heating, ventilating, and air conditioning (HVAC) systems indicated that the initial cost for the conventional cooling equipment was greatly reduced by using desiccant technology because of downsized compressors, fans, and ductworks. This cost reduction was more than enough to offset the cost of desiccant equipment. Besides, the system operation cost was also reduced. All these indicate that desiccant systems are also cost effective. This study provides an updated state-of-the-art assessment forsiccant technology in the field of desiccant materials, systems, computer models, and theoretical analyses. From this information the technology options were derived and the future research and development needs were identified. Because desiccant technology has already been applied in the commercial building sector with very encouraging results, it is expected that future market breakthroughs will probably start in this sector. A market analysis for the commercial building application is therefore included.

  1. Grid-Competitive Residential and Commercial Fully Automated PV Systems Technology: Final technical Report, August 2011

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Katie E.; Cousins, Peter; Culligan, Matt; Jonathan Botkin; DeGraaff, David; Bunea, Gabriella; Rose, Douglas; Bourne, Ben; Koehler, Oliver

    2011-08-26

    Under DOE's Technology Pathway Partnership program, SunPower Corporation developed turn-key, high-efficiency residential and commercial systems that are cost effective. Key program objectives include a reduction in LCOE values to 9-12 cents/kWh and 13-18 cents/kWh respectively for the commercial and residential markets. Target LCOE values for the commercial ground, commercial roof, and residential markets are 10, 11, and 13 cents/kWh. For this effort, SunPower collaborated with a variety of suppliers and partners to complete the tasks below. Subcontractors included: Solaicx, SiGen, Ribbon Technology, Dow Corning, Xantrex, Tigo Energy, and Solar Bridge. SunPower's TPP addressed nearly the complete PV value chain: from ingot growth through system deployment. Throughout the award period of performance, SunPower has made progress toward achieving these reduced costs through the development of 20%+ efficient modules, increased cell efficiency through the understanding of loss mechanisms and improved manufacturing technologies, novel module development, automated design tools and techniques, and reduced system development and installation time. Based on an LCOE assessment using NREL's Solar Advisor Model, SunPower achieved the 2010 target range, as well as progress toward 2015 targets.

  2. Materials, process, product analysis of coal process technology. Phase I final report

    Energy Technology Data Exchange (ETDEWEB)

    Saxton, J. C.; Roig, R. W.; Loridan, A.; Leggett, N. E.; Capell, R. G.; Humpstone, C. C.; Mudry, R. N.; Ayres, E.

    1976-02-01

    The purpose of materials-process-product analysis is a systematic evaluation of alternative manufacturing processes--in this case processes for converting coal into energy and material products that can supplement or replace petroleum-based products. The methodological steps in the analysis include: Definition of functional operations that enter into coal conversion processes, and modeling of alternative, competing methods to accomplish these functions; compilation of all feasible conversion processes that can be assembled from combinations of competing methods for the functional operations; systematic, iterative evaluation of all feasible conversion processes under a variety of economic situations, environmental constraints, and projected technological advances; and aggregative assessments (economic and environmental) of various industrial development scenarios. An integral part of the present project is additional development of the existing computer model to include: A data base for coal-related materials and coal conversion processes; and an algorithmic structure that facilitates the iterative, systematic evaluations in response to exogenously specified variables, such as tax policy, environmental limitations, and changes in process technology and costs. As an analytical tool, the analysis is intended to satisfy the needs of an analyst working at the process selection level, for example, with respect to the allocation of RDandD funds to competing technologies.

  3. [Assessment of sociodemographic and nutritional status of lung cancer patients].

    Science.gov (United States)

    Zabłocka, Katarzyna; Krawczyszyn, Monika; Pieczyńska, Joanna; Prescha, Anna; Ilow, Rafał; Porebska, Irena; Gołecki, Marcin; Kosacka, Monika; Jankowska, Renata; Grajeta, Halina; Biernat, Jadwiga

    2011-01-01

    Low sociodemographic status positively correlates with the risk of lung cancer. Nutritional status assessed during diagnosis of cancer may be a useful predictive factor for response to therapy and influences the quality of life and life expectancy after oncological therapy. The aim of this study was to assess the sociodemographic and nutritional status of patients. Lower Silesian Centre of Lung Diseases, diagnosed with lung cancer. 81 cases and 125 subjects formed the control group were included in this study. The questionnaire about sociodemographic status was performed among all respondents as well as MNA questionnaire and anthropometric measurements for evaluating nutritional status. Lower level of education, lower employment status and more frequent tobacco addiction was found in patient group then in control individuals. Nutritional status of patients was worse than the control group, which has been demonstrated mainly through a MNA questionnaire and arm circumference measurements. The risk of malnutrition or diagnosed malnutrition found in most patients assessed by MNA test may increase the likelihood of complications during treatment.

  4. A consumer involvement model for health technology assessment in Canada.

    Science.gov (United States)

    Pivik, Jayne; Rode, Elisabeth; Ward, Christopher

    2004-08-01

    Similar to other health policy initiatives, there is a growing movement to involve consumers in decisions affecting their treatment options. Access to treatments can be impacted by decisions made during a health technology assessment (HTA), i.e., the rigorous assessment of medical interventions such as drugs, vaccines, devices, materials, medical and surgical procedures and systems. The purpose of this paper was to empirically assess the interest and potential mechanisms for consumer involvement in HTA by identifying what health consumer organizations consider meaningful involvement, examining current practices internationally and developing a model for involvement based on identified priorities and needs. Canadian health consumer groups representing the largest disease or illness conditions reported a desire for involvement in HTA and provided feedback on mechanisms for facilitating their involvement.

  5. Connected Classroom Technology Facilitates Multiple Components of Formative Assessment Practice

    Science.gov (United States)

    Shirley, Melissa L.; Irving, Karen E.

    2015-02-01

    Formative assessment has been demonstrated to result in increased student achievement across a variety of educational contexts. When using formative assessment strategies, teachers engage students in instructional tasks that allow the teacher to uncover levels of student understanding so that the teacher may change instruction accordingly. Tools that support the implementation of formative assessment strategies are therefore likely to enhance student achievement. Connected classroom technologies (CCTs) include a family of devices that show promise in facilitating formative assessment. By promoting the use of interactive student tasks and providing both teachers and students with rapid and accurate data on student learning, CCT can provide teachers with necessary evidence for making instructional decisions about subsequent lessons. In this study, the experiences of four middle and high school science teachers in their first year of implementing the TI-Navigator™ system, a specific type of CCT, are used to characterize the ways in which CCT supports the goals of effective formative assessment. We present excerpts of participant interviews to demonstrate the alignment of CCT with several main phases of the formative assessment process. CCT was found to support implementation of a variety of instructional tasks that generate evidence of student learning for the teacher. The rapid aggregation and display of student learning evidence provided teachers with robust data on which to base subsequent instructional decisions.

  6. Developing technology for large-scale production of forest chips. Wood Energy Technology Programme 1999-2003. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    The national Wood Energy Technology Programme was carried out by Tekes during the period 1999- 2003 to develop efficient technology for large- scale production of forest chips from small- sized trees and logging residues. This is the final report of the programme, and it outlines the general development of forest chip procurement and use during the programme period. In 2002, a sub-programme was established to address small-scale production and use of wood fuels. This sub-programme will continue to the end of 2004, and it is not reported here. The programme was coordinated by VTT Processes. As of January 2004, the programme consisted of 44 public research projects, 46 industrial or product development projects, and 29 demonstration projects. Altogether, 27 research organizations and 53 enterprises participated. The total cost of the programme was 42 M euro of which 13 M euro was provided by Tekes. The Ministry of Trade and Industry provided investment aid for the new technology employed in the demonstration projects. When the programme was launched at the end of the 1990s, the major barriers to the use of forest chips were high cost of production, shortage of reliable chip procurement organizations, and the unsatisfactory quality of fuel. Accordingly, the programme focused largely on these problems. In addition, upgrading of the fuel properties of bark was also studied. The production of forest chips must be adapted to the existing operating environment and infrastructure. In Finland, these are charaterized by rich bio-mass potential, a sophisticated and efficient organization for the procurement of industrial timber, a large capacity of heating and CHP plants to use wood fuels, the possibility to co-fire wood and peat, and the unreserved acceptance of society at large. A goal of Finnish energy and climate strategies is to use 5 million m3 (0.9 Mtoe) chips annually by 2010. The Wood Energy Technology Programme was an important link in the long chain of activities

  7. A strategic assessment of cervical cancer prevention and treatment services in 3 districts of Uttar Pradesh, India

    Directory of Open Access Journals (Sweden)

    Dzuba Ilana

    2005-12-01

    Full Text Available Abstract Background Despite being a preventable disease, cervical cancer claims the lives of almost half a million women worldwide each year. India bears one-fifth of the global burden of the disease, with approximately 130,000 new cases a year. In an effort to assess the need and potential for improving the quality of cervical cancer prevention and treatment services in Uttar Pradesh, a strategic assessment was conducted in three of the state's districts: Agra, Lucknow, and Saharanpur. Methods Using an adaptation of stage one of the World Health Organization's Strategic Approach to Improving Reproductive Health Policies and Programmes, an assessment of the quality of cervical cancer services was carried out by a multidisciplinary team of stakeholders. The assessment included a review of the available literature, observations of services, collection of hospital statistics and the conduct of qualitative research (in-depth interviews and focus group discussions to assess the perspectives of women, providers, policy makers and community members. Results There were gaps in provider knowledge and practices, potentially attributable to limited provider training and professional development opportunities. In the absence of a state policy on cervical cancer, screening of asymptomatic women was practically absent, except in the military sector. Cytology-based cancer screening tests (i.e. pap smears were often used to help diagnose women with symptoms of reproductive tract infections but not routinely screen asymptomatic women. Access to appropriate treatment of precancerous lesions was limited and often inappropriately managed by hysterectomy in many urban centers. Cancer treatment facilities were well equipped but mostly inaccessible for women in need. Finally, policy makers, community members and clients were mostly unaware about cervical cancer and its preventable nature, although with information, expressed a strong interest in having services

  8. Cancer risk assessment of selected hazardous air pollutants in Seattle.

    Science.gov (United States)

    Wu, Chang-Fu; Wu, Szu-Ying; Wu, Yi-Hua; Cullen, Alison C; Larson, Timothy V; Williamson, John; Liu, L-J Sally

    2009-04-01

    The risk estimates calculated from the conventional risk assessment method usually are compound specific and provide limited information for source-specific air quality control. We used a risk apportionment approach, which is a combination of receptor modeling and risk assessment, to estimate source-specific lifetime excess cancer risks of selected hazardous air pollutants. We analyzed the speciated PM(2.5) and VOCs data collected at the Beacon Hill in Seattle, WA between 2000 and 2004 with the Multilinear Engine to first quantify source contributions to the mixture of hazardous air pollutants (HAPs) in terms of mass concentrations. The cancer risk from exposure to each source was then calculated as the sum of all available species' cancer risks in the source feature. We also adopted the bootstrapping technique for the uncertainty analysis. The results showed that the overall cancer risk was 6.09 x 10(-5), with the background (1.61 x 10(-5)), diesel (9.82 x 10(-6)) and wood burning (9.45 x 10(-6)) sources being the primary risk sources. The PM(2.5) mass concentration contributed 20% of the total risk. The 5th percentile of the risk estimates of all sources other than marine and soil were higher than 110(-6). It was also found that the diesel and wood burning sources presented similar cancer risks although the diesel exhaust contributed less to the PM(2.5) mass concentration than the wood burning. This highlights the additional value from such a risk apportionment approach that could be utilized for prioritizing control strategies to reduce the highest population health risks from exposure to HAPs.

  9. Mobile Technology, Cancer Prevention, and Health Status among Diverse, Low-Income Adults

    Science.gov (United States)

    Purnell, Jason Q.; Griffith, Julia; Eddens, Katherine S.; Kreuter, Matthew W.

    2014-01-01

    Purpose Characterize mobile technology ownership, use, and relationship to self-reported cancer prevention behaviors and health status in a diverse, low-income sample of callers to 2-1-1. Design Secondary analyses of cross-sectional survey data from a larger trial collected from June 2010 to December 2012. Setting United Way Missouri 2-1-1 serves 99 of 114 counties and received 166,000 calls in 2011. Subjects The respondents (baseline n = 1,898; 4-month n = 1,242) were predominantly female, non-Hispanic Black, under 50, with ≤ high school education and annual income < $20,000. Measures Cell phone ownership and use and its relationship to cancer prevention services and health status were assessed via telephone-based survey using items adapted from previous research and the BRFSS. Smartphone ownership and use were also assessed. Analysis Descriptive statistics and bivariate and multivariate associations between cell phone ownership and prevention and health status are reported. Results Three-fourths (74%) of study participants owned a cell phone and 19% owned a smartphone. Text messaging was the most popular use. Ownership was significantly associated with good to excellent health status and presence of smoke-free home policies in multivariate models. Conclusion Cell phone ownership is growing and has potential to deliver health information to low-income populations. With 16 million calls annually, the national 2-1-1 system may be a promising model and platform. PMID:24200336

  10. Life cycle assessment of products and technologies. LCA Symposium

    Energy Technology Data Exchange (ETDEWEB)

    Koukkari, H.; Nors, M. (eds.)

    2009-12-15

    VTT Technical Research Centre of Finland organised a Symposium 'Life Cycle Assessment of Products and Technologies' on the 6th of October, 2009. The Symposium gave a good overview of methods, tools and applications of Life Cycle Assessment developed and utilised in several technology fields of VTT. The 12 Symposium papers deal with recent LCA studies on products and technologies. The scope ranges from beverage cups to urban planning, from inventory databases to rating systems. Topical issues relating to climate change concern biorefineries and the overall impacts of the utilisation of biomass. The calculation of carbon footprints is also introduced through paper products and magazines. One example of LCA tools developed at VTT addresses cement manufacturing. VTT's transport emission database, LIPASTO, was introduced in detail. The use of LCA methods and life cycle thinking is described in various contexts: product development in relation to precision instruments; selection of materials and work processes in relation to sediment remediation project; and procedures of sustainability rating through VTT's office building Digitalo. The Climate Bonus project presented a demonstrated ICT support that informs about the greenhouse gas emissions and carbon footprints of households. (orig.)

  11. Expanding Health Technology Assessments to Include Effects on the Environment.

    Science.gov (United States)

    Marsh, Kevin; Ganz, Michael L; Hsu, John; Strandberg-Larsen, Martin; Gonzalez, Raquel Palomino; Lund, Niels

    2016-01-01

    There is growing awareness of the impact of human activity on the climate and the need to stem this impact. Public health care decision makers from Sweden and the United Kingdom have started examining environmental impacts when assessing new technologies. This article considers the case for incorporating environmental impacts into the health technology assessment (HTA) process and discusses the associated challenges. Two arguments favor incorporating environmental impacts into HTA: 1) environmental changes could directly affect people's health and 2) policy decision makers have broad mandates and objectives extending beyond health care. Two types of challenges hinder this process. First, the nascent evidence base is insufficient to support the accurate comparison of technologies' environmental impacts. Second, cost-utility analysis, which is favored by many HTA agencies, could capture some of the value of environmental impacts, especially those generating health impacts, but might not be suitable for addressing broader concerns. Both cost-benefit and multicriteria decision analyses are potential methods for evaluating health and environmental outcomes, but are less familiar to health care decision makers. Health care is an important and sizable sector of the economy that could warrant closer policy attention to its impact on the environment. Considerable work is needed to track decision makers' demands, augment the environmental evidence base, and develop robust methods for capturing and incorporating environmental data as part of HTA.

  12. Development and Implementation of Health Technology Assessment: A Policy Study

    Directory of Open Access Journals (Sweden)

    P Abooee

    2013-01-01

    Full Text Available Background: To provide an overview of the development of health technology assessment (HTA in Iran since 2007, and to facilitate further development of HTA and its integration into policy making.Methods: Data of this study were collected through key documents (e.g. literature, laws, and other official documentation and analyzed by experts of opinion in form of qualitative methods.Results: Health technology assessment entered to the political agenda in Iran only in 2007 with a strong impetus of an evidence-based medicine movement with the bellow objectives: Institutionalization of evidence-based decision making in Ministry of Health, Creating an localization for structural HTA in Health system of Iran, Setting up training courses in order to educate capable manpower to full up the capacity of the universities, Establishment of a new field in HTA subject in medical universities for MSc and PhD degree, International communication about HTA through national website and possible participation in international Congress.Conclusion: HTA has been established in the healthcare system of Iran but what is needed is a clear political will to push forward the objectives of HTA in Iran. Similar to other countries, advance the regulation on the adoption of new health technologies to improve not only technical or allocate efficiency, but also health equity.

  13. Technology and alternative cancer therapies: an analysis of heterodoxy and constructivism.

    Science.gov (United States)

    Hess, D J

    1996-12-01

    Theories of the construction of technology are reviewed from the wider interdisciplinary conversation known as science and technology studies (STS) and from the growing field of the anthropology of science and technology. These theories are used to contribute to research situated at the intersection of the anthropology of alternative medicine and of medical technologies. Cases drawn from the research tradition on microbial theories of cancer are considered to show how unorthodox medical theories become embedded in technologies through choices in microscope design and treatment technologies. In turn, the technologies contribute to the heterodox standing of the researchers, their research, and their therapies.

  14. Assessing middle school students` understanding of science relationships and processes: Year 2 - instrument validation. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Schau, C.; Mattern, N.; Weber, R.; Minnick, K.

    1997-01-01

    Our overall purpose for this multi-year project was to develop an alternative assessment format measuring rural middle school students understanding of science concepts and processes and the interrelationships among them. This kind of understanding is called structural knowledge. We had 3 major interrelated goals: (1) Synthesize the existing literature and critically evaluate the actual and potential use of measures of structural knowledge in science education. (2) Develop a structural knowledge alternative assessment format. (3) Examine the validity of our structural knowledge format. We accomplished the first two goals during year 1. The structural knowledge assessment we identified and developed further was a select-and-fill-in concept map format. The goal for our year 2 work was to begin to validate this assessment approach. This final report summarizes our year 2 work.

  15. The Conversations About Cancer (CAC) project: assessing feasibility and audience impacts from viewing The Cancer Play.

    Science.gov (United States)

    Beach, Wayne A; Buller, Mary K; Dozier, David M; Buller, David B; Gutzmer, Kyle

    2014-01-01

    Basic communication research has identified a major social problem: communicating about cancer from diagnosis through death of a loved one. Over the past decade, an award-winning investigation into how family members talk through cancer on the telephone, based on a corpus of 61 phone calls over a period of 13 months, has been transformed into a theatrical production entitled The Cancer Play. All dialogue in the play is drawn from naturally occurring (transcribed) interactions between family members as they navigate their way through the trials, tribulations, hopes, and triumphs of a cancer journey. This dramatic performance explicitly acknowledges the power of the arts as an exceptional learning tool for extending empirical research, exploring ordinary family life, and exposing the often taken-for-granted conceptions of health and illness. In this study, a Phase I STTR project funded by the National Cancer Institute (NCI), we assess the feasibility of educating and impacting cancer patients, family members, and medical professionals who viewed the play as a live performance and through DVD screenings. Pre- and postperformance questionnaires were administered to solicit audience feedback. Pre-post change scores demonstrate overwhelming and positive impacts for changing opinions about the perceived importance, and attributed significance, of family communication in the midst of cancer. Paired-sample t-tests were conducted on five factor-analyzed indices/indicators-two indices of opinions about cancer and family communication, two indices measuring the importance of key communication activities, and the self-efficacy indicator-and all factors improved significantly (<.001). Informal talkback sessions were also held following the viewings, and selected audience members participated in focus groups. Talkback and focus-group sessions generated equally strong, support responses. Implications of the Phase I study are being applied in Phase II, a currently funded effort to

  16. Information technologies for global resources management and environmental assessment

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, A.P.; Wang, Hua.

    1992-01-01

    Recent advances in computer and communications technologies offer unprecedented opportunities to develop sophisticated information resources management systems for global resources management and environment assessment in an efficient, effective, and systematic manner. In this paper, the emerging global energy and environmental issues are identified. Since satellite-based remote sensing systems are becoming increasingly available and produce massive data collections, the utilization of imaging processing techniques and their applications for regional and global resources management and environmental studies are described. Interoperability and interconnectivity among heterogeneous computer systems are major issues in designing a totally integrated, multimedia-based, information resources management system that operates in a networking environment. Discussions of the future technology trends are focused on a number of emerging information management technologies and communications standards which will aid in achieving seamless system integration and offer user-friendly operations. It can be foreseen that advances in computer and communications technologies, increasingly sophisticated image processing techniques and Geographical Information Systems (GIS), and the development of globally comprehensive data bases will bring global visualization'' onto multimedia desktop computers before the end of this decade.

  17. Information technologies for global resources management and environmental assessment

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, A.P.; Wang, Hua

    1992-09-01

    Recent advances in computer and communications technologies offer unprecedented opportunities to develop sophisticated information resources management systems for global resources management and environment assessment in an efficient, effective, and systematic manner. In this paper, the emerging global energy and environmental issues are identified. Since satellite-based remote sensing systems are becoming increasingly available and produce massive data collections, the utilization of imaging processing techniques and their applications for regional and global resources management and environmental studies are described. Interoperability and interconnectivity among heterogeneous computer systems are major issues in designing a totally integrated, multimedia-based, information resources management system that operates in a networking environment. Discussions of the future technology trends are focused on a number of emerging information management technologies and communications standards which will aid in achieving seamless system integration and offer user-friendly operations. It can be foreseen that advances in computer and communications technologies, increasingly sophisticated image processing techniques and Geographical Information Systems (GIS), and the development of globally comprehensive data bases will bring ``global visualization`` onto multimedia desktop computers before the end of this decade.

  18. Environmental assessment of digestate treatment technologies using LCA methodology.

    Science.gov (United States)

    Vázquez-Rowe, Ian; Golkowska, Katarzyna; Lebuf, Viooltje; Vaneeckhaute, Céline; Michels, Evi; Meers, Erik; Benetto, Enrico; Koster, Daniel

    2015-09-01

    The production of biogas from energy crops, organic waste and manure has augmented considerably the amounts of digestate available in Flanders. This has pushed authorities to steadily introduce legislative changes to promote its use as a fertilising agent. There is limited arable land in Flanders, which entails that digestate has to compete with animal manure to be spread. This forces many anaerobic digestion plants to further treat digestate in such a way that it can either be exported or the nitrogen be removed. Nevertheless, the environmental impact of these treatment options is still widely unknown, as well as the influence of these impacts on the sustainability of Flemish anaerobic digestion plants in comparison to other regions where spreading of raw digestate is allowed. Despite important economic aspects that must be considered, the use of Life Cycle Assessment (LCA) is suggested in this study to identify the environmental impacts of spreading digestate directly as compared to four different treatment technologies. Results suggest relevant environmental gains when the digestate mix is treated using the examined conversion technologies prior to spreading, although important trade-offs between impact categories were observed and discussed. The promising results of digestate conversion technologies suggest that further LCA analyses should be performed to delve into, for instance, the appropriateness to shift to nutrient recovery technologies rather than digestate conversion treatments.

  19. Final Review of Safety Assessment Issues at Savannah River Site, August 2011

    Energy Technology Data Exchange (ETDEWEB)

    Napier, Bruce A.; Rishel, Jeremy P.; Bixler, Nathan E.

    2011-12-15

    At the request of Savannah River Nuclear Solutions (SRNS) management, a review team composed of experts in atmospheric transport modeling for environmental radiation dose assessment convened at the Savannah River Site (SRS) on August 29-30, 2011. Though the meeting was prompted initially by suspected issues related to the treatment of surface roughness inherent in the SRS meteorological dataset and its treatment in the MELCOR Accident Consequence Code System Version 2 (MACCS2), various topical areas were discussed that are relevant to performing safety assessments at SRS; this final report addresses these topical areas.

  20. Advanced endoscopic imaging for gastric cancer assessment: new insights with new optics?

    Science.gov (United States)

    Serrano, M; Kikuste, I; Dinis-Ribeiro, M

    2014-12-01

    The most immediate strategy for improving survival of gastric cancer patients is secondary prevention through diagnosis of early gastric cancer either through screening or follow-up of individuals at high risk. Endoscopy examination is therefore of paramount importance and two general steps are to be known in assessing gastric mucosa - detection and characterization. Over the past decade, the advent of advanced endoscopic imaging technology led to diverse descriptions of these modalities reporting them to be useful in this setting. In this review, we aim at summarizing the current evidence on the use of advance imaging in individuals at high-risk (i.e., advance stages of gastric atrophy/intestinal metaplasia) and in those harbouring neoplastic lesions, and address its potential usefulness providing the readers a framework to use in daily practice. Further research is also suggested.

  1. Thinking Tools in Computer-Based Assessment: Technology Enhancements in Assessments for Learning

    Science.gov (United States)

    Rosen, Yigal

    2014-01-01

    One of the greatest concerns in schools today is how teachers can bring together assessment and learning in a way that is meaningful for students' thinking skills, while focusing on content standards. Better understanding of how different types of technology based thinking tools can be used for improving classroom teaching and learning,…

  2. Optical screening of oral cancer: technology for emerging markets.

    Science.gov (United States)

    Naik, Sarif Kumar; Gupta, Lalit; Mittal, Chetan; Balakrishnan, Srinivasan; Rath, Satish Prasad; Santhosh, C; Pai, Keerthilatha M

    2007-01-01

    Oral cancer is the sixth most common cancer in the world. It is one of the most prevalent cancers in the developing countries of South Asia accounting for one third of the world burden. Sixty percent of the cancers are advanced by the time they are detected. Two methods of optical spectroscopy for detection of oral cancer have been discussed here. These methods are simple, easy to handle and non-invasive. The evaluation of the data is done automatically using pattern recognition techniques, making the screening subjective.

  3. Health technology assessment in Australia: a role for clinical registries?

    Science.gov (United States)

    Scott, Anna Mae

    2016-03-31

    Objective Health technology assessment (HTA) is a process of assessing evidence to inform policy decisions about public subsidy of new drugs and medical procedures. Where evidence is uncertain but the technology itself is promising, funders may recommend funding on an interim basis. It is unknown whether evidence from clinical registries is used to resolve uncertainties identified in interim-funded decisions made by Australian HTA bodies. Therefore, the present study evaluated the role of evidence from clinical registries in resolving evidence uncertainties identified by the Medical Services Advisory Committee (MSAC).Methods All HTAs considered by MSAC between 1998 and 2015 were reviewed and assessments that recommended interim funding were identified. The MSAC website was searched to identify reassessments of these recommendations and sources of evidence used to resolve the uncertainties were identified.Results Of 173 HTA reports considered by MSAC, 17 (10%) contained an interim funding recommendation. Eight recommendations cited uncertainty around safety, 15 cited uncertainty around clinical effectiveness and 13 cited uncertainty around economics (cost-effectiveness and/or budget impact). Of the 17 interim funding recommendations, 11 (65%) have been reassessed. Only two reassessments relied on clinical registry evidence to resolve evidence gaps identified at the time of the interim funding recommendation.Conclusions Clinical registries are underused as a source of evidence for resolving uncertainties around promising new health technologies in Australia. An open dialogue between stakeholders on the role of registries in this context is needed.What is known about the topic? HTA is a process of assessing the evidence to inform policy decisions about public subsidy of new health technologies (e.g. pharmaceuticals, diagnostic tests, medical procedures). Where evidence is uncertain but the technology under evaluation is promising, funders may recommend the funding of

  4. A Framework for Assessment of Aviation Safety Technology Portfolios

    Science.gov (United States)

    Jones, Sharon M.; Reveley, Mary S.

    2014-01-01

    The programs within NASA's Aeronautics Research Mission Directorate (ARMD) conduct research and development to improve the national air transportation system so that Americans can travel as safely as possible. NASA aviation safety systems analysis personnel support various levels of ARMD management in their fulfillment of system analysis and technology prioritization as defined in the agency's program and project requirements. This paper provides a framework for the assessment of aviation safety research and technology portfolios that includes metrics such as projected impact on current and future safety, technical development risk and implementation risk. The paper also contains methods for presenting portfolio analysis and aviation safety Bayesian Belief Network (BBN) output results to management using bubble charts and quantitative decision analysis techniques.

  5. Current Status of Methods to Assess Cancer Drug Resistance

    Directory of Open Access Journals (Sweden)

    Theodor H. Lippert, Hans-Jörg Ruoff, Manfred Volm

    2011-01-01

    Full Text Available Drug resistance is the main cause of the failure of chemotherapy of malignant tumors, resistance being either preexisting (intrinsic resistance or induced by the drugs (acquired resistance. At present, resistance is usually diagnosed during treatment after a long period of drug administration.In the present paper, methods for a rapid assessment of drug resistance are described. Three main classes of test procedures can be found in the literature, i.e. fresh tumor cell culture tests, cancer biomarker tests and positron emission tomography (PET tests. The methods are based on the evaluation of molecular processes, i.e. metabolic activities of cancer cells. Drug resistance can be diagnosed before treatment in-vitro with fresh tumor cell culture tests, and after a short time of treatment in-vivo with PET tests. Cancer biomarker tests, for which great potential has been predicted, are largely still in the development stage. Individual resistance surveillance with tests delivering rapid results signifies progress in cancer therapy management, by providing the possibility to avoid drug therapies that are ineffective and only harmful.

  6. Quality assurance and technology assessment: pieces of a larger puzzle.

    Science.gov (United States)

    McDonald, I G

    2000-01-01

    Increasing integration of health care and health services research has resulted in an overlap between disciplines involved in the evaluation of clinical practice. We have examined the relationships of quality assurance (QA), medical technology assessment (TA), clinical epidemiology (CE) and evidence-based medicine (EBM) from an historical perspective. Clinicians, patients and administrators need local information on effectiveness of routine care. Information from trials alone, efficacy data, will not suffice nor can it be culled from administrative databases designed for other purposes. The current activities of QA should be therefore be expanded to include the study of the effectiveness of interventions in terms of appropriateness of use, patient outcomes and study of the determinants of outcomes, as seen from the perspective of doctors, patients, administrators and policy makers, using data collected during the course of routine patient care. With the assistance of information technology, with methodological support and multidisciplinary cooperation, clinicians can do this as part of a more broadly defined clinical research. Quality assurance and TA both evolved with the objective of studying clinical care but have quite different historical roots, complementary perspectives and objectives, use different methods and involve a different set of practitioners. Quality assurance is a type of 'formative' evaluation conducted in the clinical setting using indicators as flags of process or outcome events of interest, simple surveys and audit studies. Its primary aim is to achieve incremental improvement rather than to simply pass judgement. An important underlying assumption is that health care behaves as a complex dynamic system. Technology assessment, a form of summative evaluation with an orientation towards policy, synthesises information from formal scientific studies of efficacy in the form of clinical trials and studies of cost-effectiveness. For the evaluation

  7. Joint irrigation districts hydropower assessment study. Final feasibility assessment report. Volume I

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-02-01

    In August 1978, the United States Department of Energy and the Turlock Irrigation District entered into a cooperative agreement for a Joint District's Low-Head Hydropower Assessment Study. The purpose of the agreement was to carry out a study of the hydropower potential at sites within the borders of the Turlock, Merced, South San Joaquin, and Oakdale Irrigation Districts in California. The required data were gathered and analyzed. The results of this study indicate the total potential small hydropower capacity with the Joint Districts is 19,560 kW installed with an annual energy generation of 68,561,800 kWh. This is equivalent to oil-savings of 118,616 barrels per y.

  8. Assessing wood-based synthetic natural gas technologies using the SWISS-MARKAL model

    Energy Technology Data Exchange (ETDEWEB)

    Schulz, Thorsten F.; Barreto, Leonardo; Kypreos, Socrates [Paul Scherrer Institute, Villigen PSI (Switzerland). Energy Economics Group; Stucki, Samuel [Paul Scherrer Institute, Villigen PSI (Switzerland). General Energy

    2007-10-15

    In future, new biomass technologies can gain significant importance in the Swiss energy sector. Therefore, this paper assesses the economic conditions under which new biomass technologies become competitive. The focus of this assessment is on the production of synthetic natural gas (bio-SNG) from wood in a methanation plant. The assessment is conducted with the cost-optimization model SWISS-MARKAL (MARKet ALlocation). SWISS-MARKAL projects future technology investments and provides an integrated analysis of primary, secondary, final and end-use energy in Switzerland. In addition to a reference scenario, the effects of increasing oil and gas prices, the effects of allocating subsidies to the methanation plant and the effects of competition between the methanation plant and a biomass-based Fischer-Tropsch (FT) synthesis are evaluated. Moreover, a sensitivity analysis is performed by varying investment costs of the methanation plant. The results are in favour of bio-SNG in the transportation sector where the synergetic use of bio-SNG and natural gas reduces the dependence on oil imports and the level of CO{sub 2} emissions. (author)

  9. Ratio Based Biomarkers for the Prediction of Cancer Survival | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The NCI seeks licensees or co-development partners for this technology, which describes compositions, methods and kits for identifying, characterizing biomolecules expressed in a sample that are associated with the presence, the development, or progression of cancer.

  10. A Comparative Study on Emerging Electric Vehicle Technology Assessments

    Energy Technology Data Exchange (ETDEWEB)

    Ford, Jonathan [Sentech, Inc.; Khowailed, Gannate [Sentech, Inc.; Blackburn, Julia [Sentech, Inc.; Sikes, Karen [Sentech, Inc.

    2011-03-01

    Numerous organizations have published reports in recent years that investigate the ever changing world of electric vehicle (EV) technologies and their potential effects on society. Specifically, projections have been made on greenhouse gas (GHG) emissions associated with these vehicles and how they compare to conventional vehicles or hybrid electric vehicles (HEVs). Similar projections have been made on the volumes of oil that these vehicles can displace by consuming large amounts of grid electricity instead of petroleum-based fuels. Finally, the projected rate that these new vehicle fleets will enter the market varies significantly among organizations. New ideas, technologies, and possibilities are introduced often, and projected values are likely to be refined as industry announcements continue to be made. As a result, over time, a multitude of projections for GHG emissions, oil displacement, and market penetration associated with various EV technologies has resulted in a wide range of possible future outcomes. This leaves the reader with two key questions: (1) Why does such a collective range in projected values exist in these reports? (2) What assumptions have the greatest impact on the outcomes presented in these reports? Since it is impractical for an average reader to review and interpret all the various vehicle technology reports published to date, Sentech Inc. and the Oak Ridge National Laboratory have conducted a comparative study to make these interpretations. The primary objective of this comparative study is to present a snapshot of all major projections made on GHG emissions, oil displacement, or market penetration rates of EV technologies. From the extensive data found in relevant publications, the key assumptions that drive each report's analysis are identified and 'apples-to-apples' comparisons between all major report conclusions are attempted. The general approach that was taken in this comparative study is comprised of six primary

  11. Assessment of coal gasification/hot gas cleanup based advanced gas turbine systems: Greenfield assessment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1991-12-01

    Both the KRW fluidized-bed gasifier and the transport gasifier case studies were used for this assessment. The transport technology is a high-velocity circulating fluidized-bed reactor currently under development by The M.W. Kellogg Company. In the earlier assessment, seven design concepts or cases were identified; a process design was developed; major equipment items were identified; estimates of capital cost, operation and maintenance cost, and cost of electricity were developed; reliability was predicted; and development issues were identified for six studies. Three of the most probable cases were further evaluated for a Greenfield assessment in this report to adequately determine all costs independent of facilities at Plant Wansley.

  12. Technology assessment of applied techniques for exploitation of geothermal energy

    Energy Technology Data Exchange (ETDEWEB)

    1977-04-01

    Studies were made to elucidate the effects of technological development of natural steam and hot water on the general social and industrial environments. These were followed by studies of enhanced methods for the forecasting of these impacts. The studies included assessments of actual conditions and the preparation of regional models, ranging from rural to urban-fringe situations. The economic implications of geothermal development in various regional situations are discussed, and the models developed provide for the integration of new data and their extrapolation to as yet uncertain situations.

  13. Industrial applications study. Volume III. Technology data base evaluation of waste recovery systems. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Harry L.; Hamel, Bernard B.; Karamchetty, Som; Steigelmann, William H.; Gajanana, Birur C.; Agarwal, Anil P.; Klock, Lawrence W.; Henderson, James M.; Calobrisi, Gary; Hedman, Bruce A.; Koluch, Michael; Biancardi, Frank; Bass, Robert; Landerman, Abraham; Peters, George; Limaye, Dilip; Price, Jeffrey; Farr, Janet

    1977-01-01

    An analytical study was undertaken to estimate the present and potential technical and economic characteristics of a wide range of components and complete systems capable of converting industrial and commercial waste heat into mechanical or electrical power and/or building and process heating and cooling. The component and system technologies evaluated include: Rankine-, Stirling-, and Brayton-cycle power systems; reciprocating-, rotary-, and turbo-expanders; heat exchangers and heat pumps; thermally driven cooling and dehumidification systems; and integrated systems capable of providing multiple outputs. Extensive analyses were conducted of Rankine-cycle systems using steam, halogenated hydrocarbons, and other organic compounds as working fluids. Performance characteristics, recoverable output power, and installed costs were estimated and are presented herein for Rankine-cycle systems utilizing selected working fluids over a range of waste heat source temperatures between approximately 200 and 1000/sup 0/F. Data describing the performance capabilities, technology and installed costs of heat exchangers, expanders and thermally driven absorption, vapor compression, steam-jet cooling and refrigeration systems are presented herein together with limited performance and cost estimates for Stirling-cycle power recovery systems. The component and system data were used to provide a preliminary assessment of the recoverable energy and associated system costs when integrated with generalized waste heat sources identified by Drexel University from their two-digit SIC industrial energy survey.

  14. Quality-of-life assessment in advanced cancer.

    LENUS (Irish Health Repository)

    Donnelly, S

    2000-07-01

    In the past 5 years, quality-of-life (QOL) assessment measures such as the McGill, McMaster, Global Visual Analogue Scale, Assessment of QOL at the End of Life, Life Evaluation Questionnaire, and Hospice QOL Index have been devised specifically for patients with advanced cancer. The developers of these instruments have tried to respond to the changing needs of this specific population, taking into account characteristics including poor performance status, difficulty with longitudinal study, rapidly deteriorating physical condition, and change in relevant issues. Emphasis has been placed on patient report, ease and speed of completion, and the existential domain or meaning of life. Novel techniques in QOL measurement have also been adapted for palliative care, such as judgment analysis in the Schedule for the Evaluation of Individual Quality of Life. It is generally agreed that a single tool will not cover all QOL assessment needs.

  15. Algorithm for automatic forced spirometry quality assessment: technological developments.

    Directory of Open Access Journals (Sweden)

    Umberto Melia

    Full Text Available We hypothesized that the implementation of automatic real-time assessment of quality of forced spirometry (FS may significantly enhance the potential for extensive deployment of a FS program in the community. Recent studies have demonstrated that the application of quality criteria defined by the ATS/ERS (American Thoracic Society/European Respiratory Society in commercially available equipment with automatic quality assessment can be markedly improved. To this end, an algorithm for assessing quality of FS automatically was reported. The current research describes the mathematical developments of the algorithm. An innovative analysis of the shape of the spirometric curve, adding 23 new metrics to the traditional 4 recommended by ATS/ERS, was done. The algorithm was created through a two-step iterative process including: (1 an initial version using the standard FS curves recommended by the ATS; and, (2 a refined version using curves from patients. In each of these steps the results were assessed against one expert's opinion. Finally, an independent set of FS curves from 291 patients was used for validation purposes. The novel mathematical approach to characterize the FS curves led to appropriate FS classification with high specificity (95% and sensitivity (96%. The results constitute the basis for a successful transfer of FS testing to non-specialized professionals in the community.

  16. Algorithm for automatic forced spirometry quality assessment: technological developments.

    Science.gov (United States)

    Melia, Umberto; Burgos, Felip; Vallverdú, Montserrat; Velickovski, Filip; Lluch-Ariet, Magí; Roca, Josep; Caminal, Pere

    2014-01-01

    We hypothesized that the implementation of automatic real-time assessment of quality of forced spirometry (FS) may significantly enhance the potential for extensive deployment of a FS program in the community. Recent studies have demonstrated that the application of quality criteria defined by the ATS/ERS (American Thoracic Society/European Respiratory Society) in commercially available equipment with automatic quality assessment can be markedly improved. To this end, an algorithm for assessing quality of FS automatically was reported. The current research describes the mathematical developments of the algorithm. An innovative analysis of the shape of the spirometric curve, adding 23 new metrics to the traditional 4 recommended by ATS/ERS, was done. The algorithm was created through a two-step iterative process including: (1) an initial version using the standard FS curves recommended by the ATS; and, (2) a refined version using curves from patients. In each of these steps the results were assessed against one expert's opinion. Finally, an independent set of FS curves from 291 patients was used for validation purposes. The novel mathematical approach to characterize the FS curves led to appropriate FS classification with high specificity (95%) and sensitivity (96%). The results constitute the basis for a successful transfer of FS testing to non-specialized professionals in the community.

  17. Fuzzy-probabilistic multi agent system for breast cancer risk assessment and insurance premium assignment.

    Science.gov (United States)

    Tatari, Farzaneh; Akbarzadeh-T, Mohammad-R; Sabahi, Ahmad

    2012-12-01

    In this paper, we present an agent-based system for distributed risk assessment of breast cancer development employing fuzzy and probabilistic computing. The proposed fuzzy multi agent system consists of multiple fuzzy agents that benefit from fuzzy set theory to demonstrate their soft information (linguistic information). Fuzzy risk assessment is quantified by two linguistic variables of high and low. Through fuzzy computations, the multi agent system computes the fuzzy probabilities of breast cancer development based on various risk factors. By such ranking of high risk and low risk fuzzy probabilities, the multi agent system (MAS) decides whether the risk of breast cancer development is high or low. This information is then fed into an insurance premium adjuster in order to provide preventive decision making as well as to make appropriate adjustment of insurance premium and risk. This final step of insurance analysis also provides a numeric measure to demonstrate the utility of the approach. Furthermore, actual data are gathered from two hospitals in Mashhad during 1 year. The results are then compared with a fuzzy distributed approach.

  18. Offline Chinese handwriting recognition :an assessment of current technology

    Institute of Scientific and Technical Information of China (English)

    Sargur N.Srihari; Xuanshen Yang; Gregory R.Ball

    2007-01-01

    Offline Chinese handwriting recognition (OCHR)is a typically difficult pattern recognition problem.Many authors have presented various approaches to recognizing its different aspects.We present a survey and an assessment of relevant papers appearing in recent publications of relevant conferences and journals,including those appearing in ICDAR,SDIUT,IWFHR,ICPR,PAMI,PR,PRL,SPIE-DRR,and IJDAR.The methods are assessed in the sense that we document their technical approaches,strengths,and weaknesses,as well as the data sets on which they were reportedly tested and on which results were generated.We also identify a list of technology gaps with respect to Chinese handwriting recognition and identify technical approaches that show promise in these areas as well as identify the leading researchers for the applicable topics,discussing difficulties associated with any given approach.

  19. Simulation Technology Laboratory Building 970 hazards assessment document

    Energy Technology Data Exchange (ETDEWEB)

    Wood, C.L.; Starr, M.D.

    1994-11-01

    The Department of Energy Order 5500.3A requires facility-specific hazards assessments be prepared, maintained, and used for emergency planning purposes. This hazards assessment document describes the chemical and radiological hazards associated with the Simulation Technology Laboratory, Building 970. The entire inventory was screened according to the potential airborne impact to onsite and offsite individuals. The air dispersion model, ALOHA, estimated pollutant concentrations downwind from the source of a release, taking into consideration the toxicological and physical characteristics of the release site, the atmospheric conditions, and the circumstances of the release. The greatest distances at which a postulated facility event will produce consequences exceeding the ERPG-2 and Early Severe Health Effects thresholds are 78 and 46 meters, respectively. The highest emergency classification is a Site Area Emergency. The Emergency Planning Zone is 100 meters.

  20. Radiation safety assessment and development of environmental radiation monitoring technology

    CERN Document Server

    Choi, B H; Kim, S G

    2002-01-01

    The Periodic Safety Review(PSR) of the existing nuclear power plants is required every ten years according to the recently revised atomic energy acts. The PSR of Kori unit 1 and Wolsong unit 1 that have been operating more than ten years is ongoing to comply the regulations. This research project started to develop the techniques necessary for the PSR. The project developed the following four techniques at the first stage for the environmental assessment of the existing plants. 1) Establishment of the assessment technology for contamination and accumulation trends of radionuclides, 2) alarm point setting of environmental radiation monitoring system, 3) Development of Radiation Safety Evaluation Factor for Korean NPP, and 4) the evaluation of radiation monitoring system performance and set-up of alarm/warn set point. A dynamic compartment model to derive a relationship between the release rates of gas phase radionuclides and the concentrations in the environmental samples. The model was validated by comparing ...

  1. Health Technology Assessment of Magnetic Resonance Imaging in Shanxi Province

    Institute of Scientific and Technical Information of China (English)

    Yueze Liu; Jianwen Cao; Zuxun Lu

    2004-01-01

    Assess the current status of MRI in Shanxi province by health technology assessment method to provide suggestion and guidelines for future government decisions on the procurement and installation of new high-tech medical equipments. All of the 21 hospitals installed MRIs were surveyed.The results showed that 1 ) Diffusion of MRI is consistent with the economic development in different regional districts and hospital levels in Shanxi province. 2) There are better monetary returns of MRI in higher level hospitals than lower level hospitals. 3) Most MRIs in Shanxi province had been running at a loss, and the first class tertiary level hospitals had been making profit from providing MRI services to patients. 4) Better cost-benefit accorded with higher hospital level, more patients serviced etc. 5 ) The biggest investment risk is the initial purchase and installation of MRI. 6) Positive rates and veracity of MRI diagnosis were higher. 7) MRI is a safe equipment.

  2. Cancer Inhibitors Isolated from an African Plant | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The National Cancer Institute's Molecular Targets Development Program is seeking parties interested in collaborative research to further develop, evaluate, or commercialize cancer inhibitors isolated from the African plant Phyllanthus englerii. The technology is also available for exclusive or non-exclusive licensing.

  3. Self-assessment in cancer patients referred to palliative care

    DEFF Research Database (Denmark)

    Strömgren, Annette S; Goldschmidt, Dorthe; Groenvold, Mogens

    2002-01-01

    BACKGROUND: Research in palliative care is considered difficult due to the poor health of patients. However, patient-provided data are essential for a thorough description of patient symptomatology and for the evaluation of care. METHODS: The authors examined the feasibility of a questionnaire......-based study using the European Organization for Research and Treatment of Cancer quality-of-life instrument EORTC QLQ-C30, the Edmonton Symptom Assessment System (ESAS), and the Hospital Anxiety and Depression Scale (HADS) in cancer patients who were receiving palliative care. This report describes...... the symptomatology of participating patients and examines differences in symptomatology between patients in three palliative care functions: inpatient, outpatient, and palliative home care. RESULTS: Of 267 eligible patients who were referred to a department of palliative medicine, initial self...

  4. Assessing risks for gastric cancer: New tools for pathologists

    Institute of Scientific and Technical Information of China (English)

    Robert M Genta; Massimo Rugge

    2006-01-01

    Although the Sydney Systems (original and updated) for the classification of gastritis have contributed substantially to the uniformity of the reporting of gastric conditions, they lack immediacy in conveying to the user information about gastric cancer risk. In this review, we summarize the current understanding of the gastric lesions associated with an increased risk for cancer, and present the rationale for a proposal for new ways of reporting gastritis. In addition to the traditional histopathological data gathered and evaluated according to the Sydney System rules, pathologists could add an assessment expressed as grading and staging of the gastric inflammatory and atrophic lesions and integrate these findings with pertinent laboratory information on pepsinogens and gastrin levels. Such an integrated report could facilitate clinicians' approach to the management of patients with gastric conditions.

  5. Final Environmental Assessment for Gate 5 (Central Avenue) Interchange Improvements on F. E. Warren Air Force Base, Wyoming

    Science.gov (United States)

    2012-04-01

    PHONE TYPIST’S SUSPENSE DATE INITIALS Beckwith, GS -11 90 CES/CEAN 773-3667 rs SUBJECT DATE Final Environmental Assessment, Gate 5 (Central Avenue... Kirk Schaumman Air Quality Manager F. E. Warren AFB WY 82005 10 Final Environmental Assessment for Gate 5 (Central Avenue) Interchange Improvements

  6. Central magnetic cooling and refrigeration machines (chiller) and their assessment. A feasibility study - Final report

    Energy Technology Data Exchange (ETDEWEB)

    Egolf, P. W.; Gonin, C. [University of Applied Sciences of Western Switzerland, HEIG-VD, Yverdon-les Bains (Switzerland); Kitanovski, A. [University of Ljubljana, Ljubljana (Slovenia)

    2010-03-15

    This final report for the Swiss Federal Office of Energy (SFOE) presents the results of a feasibility study made concerning magnetic cooling and refrigeration machines. This report presents a comprehensive thermodynamic and economic analysis of applications of rotary magnetic chillers. The study deals with magnetic chillers based on permanent magnets and superconducting magnets, respectively. The numerical design of permanent magnet assemblies with different magnetic flux densities is discussed. The authors note that superconducting magnetic chillers are feasible only in large-scale applications with over 1 MW of cooling power. This report describes new ideas for magnetic refrigeration technologies, which go beyond the state of the art. They show potential for a substantial reduction of costs and further improvements in efficiency. Rotary magnetic liquid chillers with 'wavy' structures and using micro tubes are discussed, as are superconducting magnetic chillers and future magneto-caloric technologies.

  7. Determination of technology transfer requirements for enhanced oil recovery. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, T.D.; Scott, J.P.

    1980-09-01

    A detailed field study was conducted to determine the technical information needs of current and potential users of enhanced oil recovery data. Under the direction of the Bartlesville Energy Technology Center (BETC), the study (1) identifies groups which have a need for EOR-related information, (2) delineate the specific information needs of each user-group, and (3) outlines methods for improved transfer of appropriate information to the end users. This study also assesses attitudes toward the EOR-related efforts of the US Department of Energy (DOE) and the BETC, and the role each should play in facilitating the commercialization of EOR processes. More than 300 users and potential users of EOR information were surveyed. Included in the survey sample were representatives of major oil companies, independent oil companies, engineering consulting firms, university and private research organizations, financial institutions and federal, state, and local policy-making bodies. In-depth questionnaires were specifically designed for each group. This study analyzes each group's position pertaining to (1) current level of EOR activity or interest, (2) current and projected EOR information needs, (3) assessments of the BETC's current information services and suggestions for improvement, (4) delineation of technical and economic constraints to increased EOR activity, and (5) steps the DOE might take to enhance the attractiveness of commercial EOR operations.

  8. Lung cancer in uranium miners: A tissue resource and pilot study. Final performance report

    Energy Technology Data Exchange (ETDEWEB)

    Samet, J.; Gilliland, F.D.

    1998-08-13

    This project incorporates two related research projects directed toward understanding respiratory carcinogenesis in radon-exposed former uranium miners. The first project involved a continuation of the tissue resource of lung cancer cases from former underground uranium miners and comparison cases from non-miners. The second project was a pilot study for a proposed longitudinal study of respiratory carcinogenesis in former uranium miners. The objectives including facilitating the investigation of molecular changes in radon exposed lung cancer cases, developing methods for prospectively studying clinical, cytologic, cytogenetic, and molecular changes in the multi-event process of respiratory carcinogenesis, and assessing the feasibility of recruiting former uranium miners into a longitudinal study that collected multiple biological specimens. A pilot study was conducted to determine whether blood collection, induced sputum, bronchial brushing, washings, and mucosal biopsies from participants at two of the hospitals could be included efficiently. A questionnaire was developed for the extended study and all protocols for specimen collection and tissue handling were completed. Resource utilization is in progress at ITRI and the methods have been developed to study molecular and cellular changes in exfoliated cells contained in sputum as well as susceptibility factors.

  9. Proof-of-Concept of the Phytoimmobilization Technology for TNX Outfall Delta: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Kaplan, D.I.

    2001-06-04

    A series of proof-of-principle studies was initiated to evaluate the soil remediation technology, phytoimmobilization, for application at the TNX Outfall Delta (TNX OD) operable unit. Phytoimmobilization involves two steps. The first step is entitled phytoextraction, and it takes place mostly during the spring and summer. During this step the plants extract contaminants from the sediment into the roots and then translocate the contaminants to the aboveground plant parts. The second step is referred to as sequestration and it takes place largely during the autumn and winter when annual plants senesce or deciduous trees drop their leaves. This step involves the immobilization of the contaminant once it leaches form the fallen leaves into a ''geomat,'' a geotextile embedded with mineral sequestering agents. This final report describes the results to date, including those reported in the status report (Kaplan et al. 2000a), those completed since the report was issued, and the preliminary calculations of the phytoimmobilization effectiveness.

  10. Appalachian Clean Coal Technology Consortium. Final report, October 10, 1994--March 31, 1997

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, R.H.; Parekh, B.K.; Meloy, T.

    1997-12-31

    The Appalachian Clean Coal Technology Consortium is a group comprised of representatives from the Virginia Polytechnic Institute and State University, West Virginia University, and the University of Kentucky Center for Applied Energy Research, that was formed to pursue research in areas related to the treatment and processing of fine coal. Each member performed research in their respective areas of expertise and the report contained herein encompasses the results that were obtained for the three major tasks that the Consortium undertook from October, 1994 through March, 1997. In the first task, conducted by Virginia Polytechnic Institute, novel methods (both mechanical and chemical) for dewatering fine coal were examined. In the second task, the Center for Applied Energy Research examined novel approaches for destabilization of [highly stable] flotation froths. And in the third task, West Virginia University developed physical and mathematical models for fine coal spirals. The Final Report is written in three distinctive chapters, each reflecting the individual member`s task report. Recommendations for further research in those areas investigated, as well as new lines of pursuit, are suggested.

  11. ASSESSMENT OF QUALITY OF LIFE IN CANCER PATIENTS

    Directory of Open Access Journals (Sweden)

    Fereshteh Farzianpour

    2014-01-01

    Full Text Available Standards of Joint Commission International (JCI emphasize on the organizational performance level in basic functional domains including patient right, patient care, medical safety and infection control. These standards are focused on two principles: Expectations of the actual organizational performance and assessment of organizational capabilities to provide high quality and safe Health Care Services (HCS. The aim of this study was to analyze the regression model of the Quality of Life (QOL in cancer patients from Mazandaran province in 2013. This descriptive cross-sectional study was carried out on 185 cases after a chemotherapy treatment session during in the first three months that was referred to Rajaee Chemotherapy Center in 2013. The method of sampling was Purposive. General quality of life was assessed using WHO questionnaire (WHOQOL-BREF and particular life quality was assessed using researcher-developed questionnaire. Data analysis was consisted of a multiple regression method and for comparison one-sample test of Kolmogrov-Smirnov was used. Statistical analysis showed that the average of general life quality, particular life quality and total average was evaluated, 1<0.96<5, 1<1.13<5 and 1<1.04<5, respectively. Due to the low quality of general and particular life, fully integration of the care program of patient care in primary health care system, easy access and facilitation in intervention to improve the quality of life is offered. Our motivation behind the research and the implications of the research was improvement of QOL cancer patients.

  12. Cancer Stem Cell Biomarker Discovery Using Antibody Array Technology.

    Science.gov (United States)

    Burgess, Rob; Huang, Ruo-Pan

    2016-01-01

    Cancer is a complex disease involving hundreds of pathways and numerous levels of disease progression. In addition, there is a growing body of evidence that the origins and growth rates of specific types of cancer may involve "cancer stem cells," which are defined as "cells within a tumor that possess the capacity to self-renew and to cause the development of heterogeneous lineages of cancer cells that comprise the tumor.(1)" Many types of cancer are now thought to harbor cancer stem cells. These cells themselves are thought to be unique in comparison to other cells types present within the tumor and to exhibit characteristics that allow for the promotion of tumorigenesis and in some cases metastasis. In addition, it is speculated that each type of cancer stem cell exhibits a unique set of molecular and biochemical markers. These markers, alone or in combination, may act as a signature for defining not only the type of cancer but also the progressive state. These biomarkers may also double as signaling entities which act autonomously or upon neighboring cancer stem cells or other cells within the local microenvironment to promote tumorigenesis. This review describes the heterogeneic properties of cancer stem cells and outlines the identification and application of biomarkers and signaling molecules defining these cells as they relate to different forms of cancer. Other examples of biomarkers and signaling molecules expressed by neighboring cells in the local tumor microenvironment are also discussed. In addition, biochemical signatures for cancer stem cell autocrine/paracrine signaling, local site recruitment, tumorigenic potential, and conversion to a stem-like phenotype are described.

  13. TRL Assessment of Solar Sail Technology Development Following the 20-Meter System Ground Demonstrator Hardware Testing

    Science.gov (United States)

    Montgomery, Edward E.; Young, Roy M.; Adams, Charles L.

    2007-01-01

    The NASA In-Space Propulsion Technology (ISPT) Projects Office has been sponsoring 2 separate, independent system design and development hardware demonstration activities during 2002-2005. ATK Space Systems of Goleta, CA was the prime contractor for one development team and L'Garde, Inc. of Tustin, CA was the prime contractor for the other development team. The goal of these activities was to advance the technology readiness level (TRL) of solar sail propulsion from 3 towards 6 by the year 2006. Component and subsystem fabrication and testing were completed successfully, including the ground deployment of 10-meter and 20-meter ground demonstration hardware systems under vacuum conditions. The deployment and structural testing of the 20-meter solar sail systems was conducted in the 30 meter diameter Space Power Facility thermal-vacuum chamber at NASA Glenn Plum Brook in April though August, 2005. This paper will present the results of the TRL assessment following the solar sail technology development activities associated with the design, development, analysis and testing of the 20-meter system ground demonstrators. Descriptions of the system designs for both the ATK and L'Garde systems will be presented. Changes, additions and evolution of the system designs will be highlighted. A description of the modeling and analyses activities performed by both teams, as well as testing conducted to raise the TRL of solar sail technology will be presented. A summary of the results of model correlation activities will be presented. Finally, technology gaps identified during the assessment and gap closure plans will be presented, along with "lessons learned", subsequent planning activities and validation flight opportunities for solar sail propulsion technology.

  14. Meat Quality Assessment by Electronic Nose (Machine Olfaction Technology

    Directory of Open Access Journals (Sweden)

    Sundar Balasubramanian

    2009-07-01

    Full Text Available Over the last twenty years, newly developed chemical sensor systems (so called “electronic noses” have made odor analyses possible. These systems involve various types of electronic chemical gas sensors with partial specificity, as well as suitable statistical methods enabling the recognition of complex odors. As commercial instruments have become available, a substantial increase in research into the application of electronic noses in the evaluation of volatile compounds in food, cosmetic and other items of everyday life is observed. At present, the commercial gas sensor technologies comprise metal oxide semiconductors, metal oxide semiconductor field effect transistors, organic conducting polymers, and piezoelectric crystal sensors. Further sensors based on fibreoptic, electrochemical and bi-metal principles are still in the developmental stage. Statistical analysis techniques range from simple graphical evaluation to multivariate analysis such as artificial neural network and radial basis function. The introduction of electronic noses into the area of food is envisaged for quality control, process monitoring, freshness evaluation, shelf-life investigation and authenticity assessment. Considerable work has already been carried out on meat, grains, coffee, mushrooms, cheese, sugar, fish, beer and other beverages, as well as on the odor quality evaluation of food packaging material. This paper describes the applications of these systems for meat quality assessment, where fast detection methods are essential for appropriate product management. The results suggest the possibility of using this new technology in meat handling.

  15. Why ethics should be part of health technology assessment.

    Science.gov (United States)

    Hofmann, Bjørn Morten

    2008-01-01

    From the heydays of HTA in the 1970s, it has been argued that ethics should be a part of HTA. Despite more than 30 years with repeated intentions, only few HTA reports include ethical analysis, and there is little agreement on methods for integrating ethics. This poses the question of why it is so important to integrate ethics in HTA? The article analyzes ten arguments for making ethics part of HTA. The validity of the arguments depend on what we mean by "integrating," "ethics," and "HTA." Some of the counterarguments explain why it has taken so long to integrate ethics in HTA and why there are so many ethical approaches. Nevertheless, some of the arguments for making ethics part of HTA appear to be compelling. Health care is a moral endeavor, and the vast potential of technology poses complex moral challenges. A thorough assessment of technology would include reflection on these moral aspects. Ethics provides such a moral reflection. Health technology is a way to improve the life of human individuals. This involves questions of what "the good life" is, and hence ethical issues. Trying to ignore such questions may inflict with the moral foundation of health care: to help people. Additionally, HTA is an evaluation, and as such also a reflection on values. Hence, there is a profound affinity between HTA and ethics. Accordingly, ethics cannot be "integrated" in HTA as ethics is already a constitutive part of HTA. However, ethics can be acknowledged and emphasized.

  16. A scientific assessment of a new technology orbital telescope

    Science.gov (United States)

    1995-01-01

    As part of a program designed to test the Alpha chemical laser weapons system in space, the Ballistic Missile Defense Organization (BMDO) developed components of an agile, lightweight, 4-meter telescope, equipped with an advanced active-optics system. BMDO had proposed to make space available in the telescope's focal plane for instrumentation optimized for scientific applications in astrophysics and planetary astronomy for a potential flight mission. Such a flight mission could be undertaken if new or additional sponsorship can be found. Despite this uncertainty, BMDO requested assistance in defining the instrumentation and other design aspects necessary to enhance the scientific value of a pointing and tracking mission. In response to this request, the Space Studies Board established the Task Group on BMDO New Technology Orbital Observatory (TGBNTOO) and charged it to: (1) provide instrumentation, data management, and science-operations advice to BMDO to optimize the scientific value of a 4-meter mission; and (2) support a space studies board assessment of the relative scientific merit of the program. This report deals with the first of these tasks, assisting the Advanced Technology Demonstrator's (ATD's) program scientific potential. Given the potential scientific aspects of the 4-meter telescope, this project is referred to as the New Technology Orbital Telescope (NTOT), or as the ATD/NTOT, to emphasize its dual-use character. The task group's basic conclusion is that the ATD/NTOT mission does have the potential for contributing in a major way to astronomical goals.

  17. RED-IMPACT. Impact of partitioning, transmutation and waste reduction technologies on the final nuclear waste disposal. Synthesis report

    Energy Technology Data Exchange (ETDEWEB)

    Lensa, Werner von; Nabbi, Rahim; Rossbach, Matthias (eds.) [Forschungszentrum Juelich GmbH (Germany)

    2008-07-01

    The impact of partitioning and transmutation (P and T) and waste reduction technologies on the nuclear waste management and particularly on the final disposal has been analysed within the EU-funded RED-IMPACT project. Five representative scenarios, ranging from direct disposal of the spent fuel to fully closed cycles (including minor actinide (MA) recycling) with fast neutron reactors or accelerator-driven systems (ADS), were chosen in the project to cover a wide range of representative waste streams, fuel cycle facilities and process performances. High and intermediate level waste streams have been evaluated for all of these scenarios with the aim of analysing the impact on geological disposal in different host formations such as granite, clay and salt. For each scenario and waste stream, specific waste package forms have been proposed and their main characteristics identified. Both equilibrium and transition analyses have been applied to those scenarios. The performed assessments have addressed parameters such as the total radioactive and radiotoxic inventory, discharges during reprocessing, thermal power and radiation emission of the waste packages, corrosion of matrices, transport of radioisotopes through the engineered and geological barriers or the resulting doses from the repository. The major conclusions of include the fact, that deep geological repository to host the remaining high level waste (HLW) and possibly the long-lived intermediate level waste (ILW) is unavoidable whatever procedure is implemented to manage waste streams from different fuel cycle scenarios including P and T of long-lived transuranic actinides.

  18. Final Report - Assessment of Testing Options for the NTR at the INL

    Energy Technology Data Exchange (ETDEWEB)

    Howe, Steven D; McLing, Travis L; McCurry, Michael; Plummer, Mitchell A

    2013-02-01

    One of the main technologies that can be developed to dramatically enhance the human exploration of space is the nuclear thermal rocket (NTR). Several studies over the past thirty years have shown that the NTR can reduce the cost of a lunar outpost, reduce the risk of a human mission to Mars, enable fast transits for most missions throughout the solar system, and reduce the cost and time for robotic probes to deep space. Three separate committees of the National Research Council of the National Academy of Sciences have recommended that NASA develop the NTR. One of the primary issues in development of the NTR is the ability to verify a flight ready unit. Three main methods can be used to validate safe operation of a NTR: 1) Full power, full duration test in an above ground facility that scrubs the rocket exhaust clean of any fission products; 2) Full power , full duration test using the Subsurface Active Filtering of Exhaust (SAFE) technique to capture the exhaust in subsurface strata; 3) Test of the reactor fuel at temperature and power density in a driver reactor with subsequent first test of the fully integrated NTR in space. The first method, the above ground facility, has been studied in the past. The second method, SAFE, has been examined for application at the Nevada Test Site. The third method relies on the fact that the Nuclear Furnace series of tests in 1971 showed that the radioactive exhaust coming from graphite based fuel for the NTR could be completely scrubbed of fission products and the clean hydrogen flared into the atmosphere. Under funding from the MSFC, the Center for Space Nuclear Research (CSNR) at the Idaho National laboratory (INL) has completed a reexamination of Methods 2 and 3 for implementation at the INL site. In short, the effort performed the following: 1) Assess the geology of the INL site and determine a location suitable SAFE testing; 2) Perform calculations of gas transport throughout the geology; 3) Produce a cost estimate of a

  19. Evaluation of Policy and Research Interventions in Science and Technology: Consequence Assessment of Regulatory and Technology Transfer Programs

    Science.gov (United States)

    Dias, Mary Beatrice

    2011-01-01

    This research contributes to efforts in assessment studies related to science and technology interventions. The work presented in this thesis focuses on understanding the effects of policies that influence science and technology interventions, and determining the impact of science and technology interventions themselves. Chapter 1 explores how…

  20. Technology-Enhanced Formative Assessment: A Research-Based Pedagogy for Teaching Science with Classroom Response Technology

    Science.gov (United States)

    Beatty, Ian D.; Gerace, William J.

    2009-01-01

    "Classroom response systems" (CRSs) are a promising instructional technology, but most literature on CRS use fails to distinguish between technology and pedagogy, to define and justify a pedagogical perspective, or to discriminate between pedagogies. "Technology-enhanced formative assessment" (TEFA) is our pedagogy for CRS-based science…